<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV63</accession>
    <name>E8WV63_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ordered locus">AciX9_0164</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578566.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0164"/>
    <dbReference type="EnsemblBacteria" id="ADW67238">
        <property type="protein sequence ID" value="ADW67238"/>
        <property type="gene ID" value="AciX9_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0164"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_0_0_0"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="32699" checksum="142FAD9E629268B4" modified="2011-04-05" version="1">MQILKTIADMRQATTAARLASNAPIGLVPTMGALHEGHLSLVRAASQQCGTVVVSIFVNPTQFAPGEDLDRYPRTLEADLALLEQEGVDLVFVPSAREMYPNGIAATIVSTHVEVPEISDRLDGLSRPGHFRAVATVVAKLFHIVGPDLAFFGAKDAVQVAVLRAMVRDLDFPLRIVVCPTVRDADGLALSSRNSFLTPQERTHALTLSRALETARLIASHGSPTAEALREAMLSLLHGDLGVRVDYAEVVHPDTLEPLAHIRDGALLAVAAWVGETRLIDNLLLSPPTLPSPPTLKPARTEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV67</accession>
    <name>E8WV67_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0168</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578570.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0168"/>
    <dbReference type="EnsemblBacteria" id="ADW67242">
        <property type="protein sequence ID" value="ADW67242"/>
        <property type="gene ID" value="AciX9_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0168"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_17_4_0"/>
    <dbReference type="OMA" id="NMAVRRD"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="27514" checksum="03BF4A5029ED6C2E" modified="2011-04-05" version="1">MRLSFVIPAYNEEAWLQACVESIQKQTQALNLDAEIIVVNNASTDGTRALALSIPGVILVDEPRKGLTHARQAGFNRSTGALIANVDSDSRLTEGWVQQVLSTFASTPGLVALSGPVVYYDLTMLERQFVRIFYLQAWLVYALNRWILRVGSMVQGGNFVIARPALEAIGGFNLAISFYGEDTDIARRLNEIGMVRFTFDLKMFSSARRLRKEGMLTTAARYTVNYFWTTFLERPFTNTHADIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA2</accession>
    <name>E8WVA2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0203</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578605.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0203"/>
    <dbReference type="EnsemblBacteria" id="ADW67277">
        <property type="protein sequence ID" value="ADW67277"/>
        <property type="gene ID" value="AciX9_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0203"/>
    <dbReference type="eggNOG" id="ENOG50338IB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061304_0_0_0"/>
    <dbReference type="OrthoDB" id="1948285at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229943" evidence="1">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="26708" checksum="9ED88F0279927911" modified="2011-04-05" version="1">MRVFAALSGLALLCSTFASAQFQRGFSVDFTDCTEFAGEGPISYAAAAPLVPHGFTIARSATGEANIVVRATNCSKVTVDGALPQPTVLSQIGINIVPPDGTGDINNYTLIYVSNNPLLVTAFIGAGLPAHYDPQLTYEYTAPASGNGNLYVSAGALDLTRYTIYGPETAPPPNSAVPFLANWWYAPGTFFGTAVMRQQTLFPKISFGGSGVTLYTSLNSLLGKLIGGNTFSNYSALALRGVYPAAHMEVTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC5</accession>
    <name>E8WVC5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0226</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578628.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0226"/>
    <dbReference type="EnsemblBacteria" id="ADW67300">
        <property type="protein sequence ID" value="ADW67300"/>
        <property type="gene ID" value="AciX9_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0226"/>
    <dbReference type="HOGENOM" id="CLU_2180129_0_0_0"/>
    <dbReference type="OrthoDB" id="1871735at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="12372" checksum="8C982902A4817E26" modified="2011-04-05" version="1">MTPSAEAHNETLRGYTDLTLFNLESDSARIGFDLTMTLANSKGGHLTLHCSDVQNLELNPNGEDFKRFLGLHIEDLREDGLERIRYSLEDLENEAIFLHCANIQLERPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC7</accession>
    <name>E8WVC7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578630.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0228"/>
    <dbReference type="EnsemblBacteria" id="ADW67302">
        <property type="protein sequence ID" value="ADW67302"/>
        <property type="gene ID" value="AciX9_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0228"/>
    <dbReference type="eggNOG" id="COG0754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059175_0_0_0"/>
    <dbReference type="OMA" id="QWNSLHE"/>
    <dbReference type="OrthoDB" id="692145at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="46716" checksum="97B6849F43413655" modified="2011-04-05" version="1">MKRIQLTPRPDWQQKVESAGLTFHSPAAMAPQPYWEESAAYEFTAAEIDTLEAAGNELQTMCLAAAQHVIDKQRYNELAIPPAAIPLIEWAWNQEPPALYGRFDISWAGAQSGQPPKLLEYNADTPTSLVEAAVIQWSWLEDMTGNLPVFAKPDQFNSIHDRIIAKWKDVKDYLTEPVYFAGLQADAPDPATALDYAEDYLTVTYLQDTANQAGLDTRAIALQDIGWNQERLAFVDTDPAENQISSLFKLYPWESMVVEEFGPAALSTYHQVTWIEPIWKMLLSNKGILPILWELYPNHPLLLEAHFEASASAWTTVGAPRTGSDMTSYVRKPLHSREGANIQIVRPNAQLVETSGPYGDGPFIRQAIAPDAIFPGRGGAPRYPVLGLWMIDQDCSGLGIRESGGPITDNLSSFIPHFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC9</accession>
    <name>E8WVC9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578632.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0230"/>
    <dbReference type="EnsemblBacteria" id="ADW67304">
        <property type="protein sequence ID" value="ADW67304"/>
        <property type="gene ID" value="AciX9_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0230"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_0"/>
    <dbReference type="OMA" id="ERVDLWQ"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="379" mass="42287" checksum="88ED991C8B9EE854" modified="2011-04-05" version="1">MRPPRVAYFPDSFHEVNGVAHTSRNFEAYARRHNLPFLCVRAGNKPSGINGSVQTLELPRSRAAVGVEKDLSFDPLFWRHEKAIADLLHAFKPDIIHLTGPSELGIFAAYFAWKLNLPLAASWHTNVHEYAARRLPHLSPKTSQVVENKTLGIMGWFYRRAQLLFAPNRDLCQMLESKAHKLCHLMERGVETQIFSPAKRKRKDAKPLILGYVGRLSIEKNVALLPRIQHELNAAGIETKFLIIGQGDLESGLRKDLQSVYFAGVLRGEALAEAYANMDLFIFPSHTDTFGNVVLEALASGVPAIVTPDGGPKYIVKPNITGMIAADEDFAATILELLRDPNRMAEMGRNAHEYALSCSWDAVFDRVYAAYADTLIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK0</accession>
    <name>E8WVK0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1389</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579770.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1389"/>
    <dbReference type="EnsemblBacteria" id="ADW68448">
        <property type="protein sequence ID" value="ADW68448"/>
        <property type="gene ID" value="AciX9_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1389"/>
    <dbReference type="eggNOG" id="COG2009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078991_0_0_0"/>
    <dbReference type="OMA" id="YDMMANI"/>
    <dbReference type="OrthoDB" id="750409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="29612" checksum="690052D34165A5BB" modified="2011-04-05" version="1">MAAAAPVAPPDLAGSNKGVKPLRAGQGHSFLWRRLHSLSGIIPIGAFLVEHIVSNFETWNGPLAYAQQVKLLNSLPLVRFLEWGLIFIPLAFHALYGVWISFRGRVNVNVYPWASNWMYITQRVTGIIALAYIIQHVVRQRFMGVQLPEHPGAAFAKVQHELSNPWMLAIYVVAMIATTWHFAYGIWLFCAKWGITPGDKARKRMGYACAGIGSVLCLMGLISIYAVVYKYPNVPQDVMPEQPAGVTLPAPNIAPPNSTNPSQPGEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL2</accession>
    <name>E8WVL2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2509"/>
    <dbReference type="EnsemblBacteria" id="ADW69541">
        <property type="protein sequence ID" value="ADW69541"/>
        <property type="gene ID" value="AciX9_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2509"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068226_2_2_0"/>
    <dbReference type="OMA" id="IGQIYMV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="17239" checksum="F6A3F680909375A0" modified="2011-04-05" version="1">MFLAPQELRTYFITTVTADRHRLFQLDRNATLLLNILETHRLKQTYALHAFVLMPDHVHLLLTPSPLISLEKSMQLIKGGFSFQLKSGKEVWARSYDSRRIEDRESFLNHETYTHLNPVKSKLSPTPAAYPYSSAALPHRTDPPPSHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM6</accession>
    <name>E8WVM6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">AciX9_2525</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580870.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2525"/>
    <dbReference type="EnsemblBacteria" id="ADW69555">
        <property type="protein sequence ID" value="ADW69555"/>
        <property type="gene ID" value="AciX9_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2525"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_0"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="28683" checksum="09600EF835A05675" modified="2011-04-05" version="1">MKTEIRQKFIVGNWKMHTTSFEAQQLAKGIVDGLAAPDHVTVVLCPPFPYLPIVGDMLRGSRVALGAQNVYPETEGAFTGEVSPNMLLDLDCKYVIVGHSERRHKLGESEAFINRKVKCALDSGLDVILCVGETLEQRQGGRTEAVLDHQLSTGLDGVSSDMLSHLSVAYEPVWAIGNDEHHATPQQAHDTHVLIRRKLTQILGATWSEELSVHYGGSVEPGNAAAFLGQDGIDGVLIGGASLKADEFLAIVNAGICETEAEMQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR8</accession>
    <name>E8WVR8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix, AraC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580912.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2570"/>
    <dbReference type="EnsemblBacteria" id="ADW69597">
        <property type="protein sequence ID" value="ADW69597"/>
        <property type="gene ID" value="AciX9_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2570"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_1_0"/>
    <dbReference type="OMA" id="SVAIHHD"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="182"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="293" mass="33194" checksum="1DE72B7D85E4C179" modified="2011-04-05" version="1">MERVDVDLATTAPHPALRRFVRYYSQRRIVPGDDLQEPVTARLGGLFEFHFESLYRIPIVGTDRFESCAPMLVVGPITYRRLQLTADGTVESLTVMFHPFGLYELFGIPTNLLTEHAVEAHSLLGRSISQLYATLGEARTFPTRVRLLDQFLLKRLYSKSRARDSHWARSLALVSQDRGAHTVRELAASLNISPRQLERRSLEFSGMTPQTMARVARFVHALRVKRASNHRRSVSWTEIAHASGYYDQMHLIREFRLMGGATPTALTAQLQSHHGASLLLRPSAWGKAFNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV2</accession>
    <name>E8WVV2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster loop</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582020.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3710"/>
    <dbReference type="EnsemblBacteria" id="ADW70711">
        <property type="protein sequence ID" value="ADW70711"/>
        <property type="gene ID" value="AciX9_3710"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3710"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_0"/>
    <dbReference type="OMA" id="HEVLMLH"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="27745" checksum="27C9390D09D65A9B" modified="2011-04-05" version="1">MEPETLFPVPPDPRIIEIDRRLLAHYGQPPPRDVWNPLDQFIYSLLSSRTKTEQSHQVMRDLRARFGTWENLRDAAVAEIEQTLQIITFPEVKALWLKKDLMEITARCGELSLEFLAKYRTNKIRSWLEQFEGVGAKTSAAVVNFSTLRRRALCVDSHHLRVTQRLGLTPRADAAITEERLMRKIPADWDAIKLDDHHSLIKKHGQELCTFAEPHCRRCPLLDMCPEGQKQTKANPSDIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ5</accession>
    <name>E8WVZ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582062.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3754"/>
    <dbReference type="EnsemblBacteria" id="ADW70754">
        <property type="protein sequence ID" value="ADW70754"/>
        <property type="gene ID" value="AciX9_3754"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3754"/>
    <dbReference type="eggNOG" id="ENOG5034427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2332669_0_0_0"/>
    <dbReference type="OMA" id="TTANDYK"/>
    <dbReference type="OrthoDB" id="2082439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="101" mass="10889" checksum="53E7949949077D82" modified="2011-04-05" version="1">MSQTAYDTPRTLGGGYLFGIPMKDLGWFASLLMGLATGFMGFFGATFFAIVGLLIYNAGGHHTVDYSYSYSRVGLPVGILFAVVALGYLGTMWAKRMGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW41</accession>
    <name>E8WW41_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0275</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0275"/>
    <dbReference type="EnsemblBacteria" id="ADW67347">
        <property type="protein sequence ID" value="ADW67347"/>
        <property type="gene ID" value="AciX9_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0275"/>
    <dbReference type="HOGENOM" id="CLU_1132341_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="27133" checksum="7E04E6F0BC6A3BE3" modified="2011-04-05" version="1">MSWKPFDFGVTELRSLDGVVGEDSGLIHSTRPERATGYDGLSYFVKGPELEIVFAELTGCILANAVELPVPCARVCSFQGNLLAGTRKISQVRAAIDMFISSPRLVTNHETLYDAAVVDVWLANYDRNMGNIVGTPNGGSKIDFVFIDFEKSIVLRQYPNMLAAQRAPRDFWPSEDLGRLMSERKPLFPPPGIMSRIRGMNENRCLEISAEVADALGGVPWHEDTAFVLAARAANIERLTREVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW65</accession>
    <name>E8WW65_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0299</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578699.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0299"/>
    <dbReference type="EnsemblBacteria" id="ADW67371">
        <property type="protein sequence ID" value="ADW67371"/>
        <property type="gene ID" value="AciX9_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0299"/>
    <dbReference type="eggNOG" id="ENOG5030PBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292878_0_0_0"/>
    <dbReference type="OMA" id="ETQNAFP"/>
    <dbReference type="OrthoDB" id="1757472at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="22163" checksum="14FFE0267A47BB2E" modified="2011-04-05" version="1">MNAKRMMAIGSCVALLAAAGCKKTADNKINYTSAINTYYSSRPACLWTDSVKFPVQADTSDTTKTQGYDALVDQGLLMRTTAEKKVFIVASKQVTNYDISDKGRGSWTPDTQEPGAGNFCYGKPSVKSIDSSTPTTDKPGATTTVGYTYEVSGAPGWATAAETQTAFPGVAAQLSGPKTASATLTNTTSGWAVTSGPGRATRPASSADGKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW90</accession>
    <name>E8WW90_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1415</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1415"/>
    <dbReference type="EnsemblBacteria" id="ADW68473">
        <property type="protein sequence ID" value="ADW68473"/>
        <property type="gene ID" value="AciX9_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1415"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_0_0"/>
    <dbReference type="OMA" id="IRVMLPA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10299" checksum="118ED79A284F0992" modified="2011-04-05" version="1">MSIKIILPTAFIRHTDGQKQLTSQAANLPALITDIDQNFPALSTQIKDETGKLRRFINVYVNDEDIRFLGGETYSFQDGDEVMLIPSIAGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD3</accession>
    <name>E8WWD3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1463</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579836.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1463"/>
    <dbReference type="EnsemblBacteria" id="ADW68516">
        <property type="protein sequence ID" value="ADW68516"/>
        <property type="gene ID" value="AciX9_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1463"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228722_0_0_0"/>
    <dbReference type="OMA" id="REHWQES"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2349"/>
            <end position="2373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2476" mass="271581" checksum="1EBC3DA3DBB638AB" modified="2011-04-05" version="1">MRSFPDRTLARIGVLVALAVPATFAARADLPLWMQSVVSNSSIEAALYRTMDLPGIRMLYPRPPAEAQHELTALVSAKPDTAQLYALRAHADEQALDFTAAEQDWKSFAAHSKESAAAEFQLADYYHRRNQAQQEITALQQAASLPSSATEKFLSADKQQAWMAYPRALSVAHDQGLSDDITLAIDKAWITRYPQEPAPRATLISTLLRQRRFDETQHAIADYQTAFPQDQILPIKATALLALDQNTPDATTRALALFDKEYQPLWPSDLIQTYFQLLTATHTAHAMLTNAQAQLVQHPDDLNAATRIVFYFQQQGRTQAATDTIARYAAGKDASHTPWSPDELYTFATLLSRFSQYPSAARYYFALASTPGHLAATSQSPEEAGLAGIIHILLNAPDQAIDLGSGNLSIYGDLATIDRGPGYLNGILSLWLNSQNPASELSSEEQKAVPYFHRAKAAELLTGLDQRFPTSTARPALHADLIQALATYGDDTAVKQAGQKFLADFTQAPERMQVALQLADAYARTGDTKAEFALYESLLTELSAPLQGMPLTAAGTQAPATTPSATDTETLEVQTSAPPSTAALLQQALVLTPTPPSTTAKAQAYQQILNRYLGRLATTNQLPAALAVLKKELDRNPNDPLLYERLADFLQQNNLAAQQEQVYQQALARFNDTSFYNKLARLYLRERHREDFSTLTRKVVDTFEGTDLEQYFANVNHTWPEAYLQLNLYAHQRFPHDLAFTRNLLSAYETKGTADPAAHERLLREHWQESPDLQAQFFDLLSRTQKLPTELAALEALAPSPAEQTKNPAAAQELAELYLWQSHFEQSAPLLGQLADQYPAEQSIGTEAASVFRSLAYFDPTQIAHSVNISRHLSAADPTNLDHLATIGDTYADSTATSLNLDAGNQLTQAAPYWLAMANIHPGLPDGYLESATVFWDYFQFDGALAQIESARKHFNNPALYAYQAGAIDENKRDVPRAIAEYIAAITAEPAHTHGTESEAGTESDAHSRLLTLATRPQFKTLIDQATASAASAHPTLATLELRADILEALQQKSAIAPLVEAAIDKSTTVDSLQQLATFSQAHQLPAQYRSAIQHEIALATDPIQHIELQFQLANAFRDAGDLPSALHLIDSVHQSNPKLIGVVRTTTEFYWNNKQPKQAVATLVQASHEANPTLACGYTLEAIAKSNESADYIGARTLLKPLLNADPFNPQYLNLQAQSFSLAHDDAALRDLYSSTLAALKTAPLSAPEKRDKIALARHAMIPALTTLKDYDGAIDQHIALISAFPEDPTILQAAASYARLHARETRLIAFLNKTAANSPRDSRFLIDLARVDVQFEDYPGALAAYSKAIAIRADRPDLYIARADLEEHQQAFDAACADYDRLYLLTYRDPQWMEKSALARARQGKPDLAVKALQTARIEGRPASAGNNFRVADQLESWNLISQATTFAEEGVKLAGDDLLTTPQNNSGAVLYVRLLARQRKASDAFALLTRLLQSSTTSPSAPAVIVQQVEQKGLASVTDADWRKRLVAMRQQQAQTTYRDAVQQLCNAVASFYTPEEKSSFATLLDARRANRPAAEVAATWIPAARTAGLKDREAVWRRDVLLNSPRLGTARLNEFDTLEASRMDNIVRAQTLDAYAALVKPNVQTKVLTMAARAWRDAGDKTHEIADLRKLVLGHQQQQAEQRLFELYLAGDLTALLQLTTGKSHVADQAANFVLANATQPLAYKALQNRSLGRAPVWASANSALLGLYFADMSSSTDSAFQAALADQTIGERLQSRPDKSRQLVGDPWFYYGSRYGVWLTLSPKPTHDPEDFLPSDIEHAPNDAASYLALAQLYLDAHNVDGALGEYRHAIELDPIDPTPNIAMAEALWSANRHEEALAAWNQGLTKLRAMVDEHAVPETFWTQFGVLAKEAHDHQLGAKLKPGMSLVLDAYLRKNGDYRSSELLHSAWLSLEKENLGKAVDWMISLIKSMPLSAQSNSLSALAYEPWFPKPQMERVYRLQIALLQGHPQSEPAAQSTGYDDYSLTQLTTVQTTYLNWLITANRIADAQHLYDSIPASQRQDDPLQLASIVLAARQSQLPALLATYQSDPSAAPSLSQLSLAANRLRLEKDSANSRLLLEYVFQQKLQQQLLTAPDYLALAEARIDTADLPGALDLLNRLTLQGNLYDNLDAASTLLVRTGHNAEALPLLTRLANGTPWNPNFRLRLGQAQLALKQTSAASATLSALAAGDDAPYALRAQAAEALHSAPTAKQFSSAELNLVASGKATPQQADQPYFVYARILAATQATPAQRSTILRDALKIAPDAMRNGLRLQLFHAELAQSHDEQASAAIEPILPAIRSLLAPPATPDDAQPDNEAPQTDTMPTLDIPYSVDSILNTPASRLSLALALASMHEHTHASAEAITDLQAALELTNAPPQKLTLQSRITTLEDTLNLQRQNNSRLPILQNALTQTNLVRPRLTAAAAQVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH3</accession>
    <name>E8WWH3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2612</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2612"/>
    <dbReference type="EnsemblBacteria" id="ADW69637">
        <property type="protein sequence ID" value="ADW69637"/>
        <property type="gene ID" value="AciX9_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2612"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_0_0"/>
    <dbReference type="OMA" id="HFHADAG"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="132"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="31158" checksum="A9FB28460AC9965A" modified="2011-04-05" version="1">MAVEKQAGHAEVRAYLEYFRDMGVYDFYRNGEPQAIEAATMEAVVERVESVRATPVAPVVAVVETGPSVPATQAAAVGFDIAKPVSFDDLAPLPEVRVAAGDRAAALAVIRADIGDCTRCPLAYGGRRNIVFGDGDAKARLMFVGEGPGADEDEQGLPFVGKSGQLLNNMIGAMGLSREQVYIANIVKCRPPANRAPEPVEANTCTQFLVRQMDVVQPEYVVALGATAATYLLGVKQSLASLRGRWHDVRGAKAVVTYHPAFLLRDPRQKGEAWKDLQMVMAAMGLKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL1</accession>
    <name>E8WWL1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ordered locus">AciX9_2650</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580990.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2650"/>
    <dbReference type="EnsemblBacteria" id="ADW69675">
        <property type="protein sequence ID" value="ADW69675"/>
        <property type="gene ID" value="AciX9_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2650"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_0"/>
    <dbReference type="OMA" id="HNVRMRQ"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="348"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ADW69675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="584" mass="64609" checksum="BDED4376D492489A" modified="2011-04-05" version="1">MDNISLARLLDETASLLEIDGADIFRIRSYRRAAEAVEQQTTQLATLATPEADPKALLAIAGIGKAMAANIRDLVATGSMPLREELLQKYRPTMLELLRLPGMGPKTVALVWSALQVSNIDELEAAAKAGHLAALPRMGEKFTVKLLKGIEDHRKNSSRFRIDQARDYAEKISQLILAFPGIDQVTPAGSLRRGRETVGDLDLLATGPACEPDVVASAVEHVATLPLIDKLMARGQNKVTFTLRNNLQVDVRLLPRSSYGAALQYFTGSKHHNVALRQRAIKRGMTLSEYALLRLEDNKIIASESEEAIYNALDLDFIPPELRENCGELEAAANHTLPQLITLADLHGDVHMHTSETDGTYTIREMAEAAILRGRRYIAITDHSKNLAMTNGMNDERALAHAARVRQVNQEMEGRIHIFTGIECDILGEGEMDLTDETLAQLDIVIASVHSKFDQPIEVMTARVLRAIENPYVRILAHPTGRKLLRRDPYKIDLEQIFRRASELGVAVEHNAAPARTDLSDSHMRLAKSLGCKIVVNTDAHATDELDHMQHGIVQLRRAWLTSADVINTAPTPEDFLASLRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM4</accession>
    <name>E8WWM4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582077.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3769"/>
    <dbReference type="EnsemblBacteria" id="ADW70769">
        <property type="protein sequence ID" value="ADW70769"/>
        <property type="gene ID" value="AciX9_3769"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3769"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_0_0"/>
    <dbReference type="OMA" id="HEIPKKQ"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10693" checksum="A316DB170EACCDED" modified="2011-04-05" version="1">MAKGMTKTALVRALAEKMELTNKQTAAFLDLLAETAVKETKKNGEFTIPGIGKLVKAERKARLGRNPQTGETIKIKAKTVVKFRVAKIAKDTIAPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW0</accession>
    <name>E8WWW0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0366</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578766.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0366"/>
    <dbReference type="EnsemblBacteria" id="ADW67438">
        <property type="protein sequence ID" value="ADW67438"/>
        <property type="gene ID" value="AciX9_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0366"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014754_0_0_0"/>
    <dbReference type="OMA" id="AHKINNP"/>
    <dbReference type="OrthoDB" id="1432514at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="54"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="29862" checksum="CC76190E25F74595" modified="2011-04-05" version="1">MSALYPSPEQPVDTGLEVLELSTDPSFTARQLHTRDLAVQMEGMRRLTHAFVSSPETILQELVNAAIDLCGADSAGISVEQENRTEENYYRWVATAGEFAGFLNATLPHHPSACTLTLERGRPQLFRVTKPFYDLLGVSAPVVTDGLLLPWQADDTRGTIYVVAHGRPEAFDSEDLRLMQVLADFAAMAVRHQSQQKTLLQQASNTAAAAMAHTLAHEINNPLQSLTNVVYLASEGHSAADATALANDLSAPLQRLSGLVSKLLALPYDTLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW6</accession>
    <name>E8WWW6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1474</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579847.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1474"/>
    <dbReference type="EnsemblBacteria" id="ADW68527">
        <property type="protein sequence ID" value="ADW68527"/>
        <property type="gene ID" value="AciX9_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1474"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_0"/>
    <dbReference type="OMA" id="TPHAKPH"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26322" checksum="EF5A4610C9179628" modified="2011-04-05" version="1">MLLITPQLLVFDLDGTLIDSRTDLCNSVNATLEHFGQPALPENVVASYIGDGVQMLVRRALGHAHMIAAGATEDAAPSPHDDALINEATRWFISYYHDHKLDFTYVYPGVIESLEQIRSQRPDLPMAVLTNKPVHPSRDICRHFGMDRFFFKVYGGNSFANKKPDPAGLHILMGEASLLIGDAITPGQTVMIGDSHVDVETARNAGTHALGCTFGLSPQTLALAKPDVSVDSAFDWPSALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX10</accession>
    <name>E8WX10_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1518</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579890.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1518"/>
    <dbReference type="EnsemblBacteria" id="ADW68571">
        <property type="protein sequence ID" value="ADW68571"/>
        <property type="gene ID" value="AciX9_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1518"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_1_0_0"/>
    <dbReference type="OMA" id="CSAAGMF"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="24857" checksum="7A030CDD525173CC" modified="2011-04-05" version="1">MSSSPCTDIEIDEVSALEDAATQEASGPELSRRSFVKAAGILSAATATGLPGVALAAPASPATAQPQMKSITLKVNGASQNLSVDTRTSLLDALREQLDLTGTKKGCDHGQCGACTVLVDGRRVNSCLTLAVVAEGAEITSIEGLAKGDQLHPVQASFLEHDGYQCGYCTPGQICSAAAALSEAQKGDLSIVSFQTGNTAKPTMSDEEIRERMSGNICRCGAYPNIVAAVRAVAQQQGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD0</accession>
    <name>E8WXD0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ordered locus">AciX9_0391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578791.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0391"/>
    <dbReference type="EnsemblBacteria" id="ADW67463">
        <property type="protein sequence ID" value="ADW67463"/>
        <property type="gene ID" value="AciX9_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0391"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_1_1_0"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23250" checksum="B5FF85A8CE34B40D" modified="2011-04-05" version="1">MSQRIGLTGGLGSGKSTAAAMLAAHGAHILSADEIGRALMQPGTPVSQAIAHHFGPQVLSPDGSLNRPTLARLAFQDGRVEELNAIVHPATIARQLELTEAILTQNPAAIVVTESALIFETKFGDNWRDRFDALILVTAPDWLKIQRHIRRALERTPTADPETLAAEARRILLRQIPDAEKAPECDYIVENETTLEALQTQIDHLWLQLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ2</accession>
    <name>E8WXJ2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1555</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579927.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1555"/>
    <dbReference type="EnsemblBacteria" id="ADW68608">
        <property type="protein sequence ID" value="ADW68608"/>
        <property type="gene ID" value="AciX9_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1555"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_1_1_0"/>
    <dbReference type="OMA" id="MAPHFRQ"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233468" description="TPM_phosphatase domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="27010" checksum="6E852F4476D41016" modified="2011-04-05" version="1">MTLRLPRFLVLLLLLLPAAGVVRAEKVADLPLPTSYVNDFAGVLSPGTKQNLEDLCVQLHQKANADVAVVTIKTLEDDEDVDDFAAKLEEKWKLGKKGEDRSLIYLLVLNPHKMKVEVGYGLEGILPDARVGRILDTAVPSATAGDYDQALLTGTQGLADVIAADAHVTLTGTVHHYRREGSGQRQRGGFGQLIVVGLFVLVLIILVSTGNIGWAWMLLSMFTGGGGGGGGRDDDRGGGFGGMGGGSSGGGGASRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ6</accession>
    <name>E8WXJ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1559</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579931.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1559"/>
    <dbReference type="EnsemblBacteria" id="ADW68612">
        <property type="protein sequence ID" value="ADW68612"/>
        <property type="gene ID" value="AciX9_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1559"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_2_0"/>
    <dbReference type="OMA" id="KLEYQFP"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17662" checksum="74D0753925258D99" modified="2011-04-05" version="1">MKEPIRKLDANGAFNPPRPTRLVVAALILRDLPTLGLPANAREVLICQRKPDQPMSLKWEFPGGKIENGETSEQALARELEEELGITATIGRQVARVRHKYRNGGAIDLQFFLVDAFTGALENRIFNDVRWSPLAALPTYDFLAADLGLIKDLSEGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN9</accession>
    <name>E8WXN9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of Hsp90 ATPase 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579974.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1602"/>
    <dbReference type="EnsemblBacteria" id="ADW68655">
        <property type="protein sequence ID" value="ADW68655"/>
        <property type="gene ID" value="AciX9_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1602"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_3_0"/>
    <dbReference type="OMA" id="LVFTHAW"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="19072" checksum="10B0814B4A0F1255" modified="2011-04-05" version="1">MTQKTGSEVERMTVTRIFDAPRELVWKAWTDPKYVMQWWGPKEFTCPVCKMDFRVGGKFLYGMKSPDGQTFWNAGEYHEIIPFEKIASSMYFADSEGNKVEAADLGIEHEAIEGAYDVTLFEDLGDGRTKLTFIGNEPAESAKDSGQLEGWNQILDKVAEIVAELVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU2</accession>
    <name>E8WXU2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_2763</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581102.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2763"/>
    <dbReference type="EnsemblBacteria" id="ADW69787">
        <property type="protein sequence ID" value="ADW69787"/>
        <property type="gene ID" value="AciX9_2763"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2763"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_0"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="200"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="415"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="599" mass="64160" checksum="02E3AB166082171D" modified="2011-04-05" version="1">MTNNQHPQLTGSEILWATLAGEGTTTVFGYPGGAILPIYDALRKFPTIHHVLVRHEQGASHMADGYARASGRVGVCMATSGPGATNLVTGIATAMLDSIPMVAITGQVSSKVLGSDAFQEVDITGITLPITKHNFLVTRAEDIAPTVRLAFQIAQQGRPGPVLVDITKDAQQASAPFDFDSAAPPIHRPHPMLRATSNAIREAIALITSAKRPVILGGHGITQSGAEAEVITFAERLQIPIASTLLGLGSIPAGHPLSLGMMGMHGESWVNQAIQESDLLLAFGMRFDDRVTGNLASYAPNAKKIHIEIDPSEISKNVKADVALIGDLKEVLNTLLPLLEGRHSERSSEPPYLSSSEAPKNPWLQHINTSKGTAAVRDILSLPDNGHLYAAHVINDIWREAVAAGREKDTIIVTDVGQHQMWEAQYFKHEAPRSLVTSGGLGTMGFALPAAIGAKSACPDKDVWVIAGDGGFQMTASELSTIMQEGLAINIAVINNGFLGMVRQWQETFYDKNYSASPILSPDFVMLAAAHGISGAHVFQRKDVTPTVTKARTSGKPFLINFQVEKEDGVYPMIAPGAALHEMVRRPLHDPLLETAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU8</accession>
    <name>E8WXU8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581108.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2769"/>
    <dbReference type="EnsemblBacteria" id="ADW69793">
        <property type="protein sequence ID" value="ADW69793"/>
        <property type="gene ID" value="AciX9_2769"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2769"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126578_1_1_0"/>
    <dbReference type="OMA" id="YVAFWRG"/>
    <dbReference type="OrthoDB" id="2063459at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10701" checksum="9D7FD2444ACE61D2" modified="2011-04-05" version="1">MAKAMWNGQVLAESETTQLVEGNVYFPDESVKREFFRPSSTTSSCPFKGQARYYSLIVDGQENPDAAWYYPDPKPAARAIKHHIAFWRGVEVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX7</accession>
    <name>E8WXX7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578844.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0444"/>
    <dbReference type="EnsemblBacteria" id="ADW67516">
        <property type="protein sequence ID" value="ADW67516"/>
        <property type="gene ID" value="AciX9_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0444"/>
    <dbReference type="HOGENOM" id="CLU_2206318_0_0_0"/>
    <dbReference type="OMA" id="GWHGHED"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230055" evidence="1">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="11671" checksum="DAD34DAF7D30D9E3" modified="2011-04-05" version="1">MKITNVKAMVAKVMTVGLLAGAVVMAAPAAQAQVRVGIGIGVRGPVYGGPAYGGPVYAAPVYGRGYGYGYGYGYPGYYGRREVIVRHDDWRRGRDFDRDRHYGYYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY07</accession>
    <name>E8WY07_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0474</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578874.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0474"/>
    <dbReference type="EnsemblBacteria" id="ADW67546">
        <property type="protein sequence ID" value="ADW67546"/>
        <property type="gene ID" value="AciX9_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0474"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_0"/>
    <dbReference type="OMA" id="ESSIMEY"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="409"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="551"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="820" mass="90883" checksum="C8F731D45ED5270F" modified="2011-04-05" version="1">MQDGVLVIILAELLVFLLWSMNRGRSDLRFRCWFLGWLLVLVHFISLLWHPAPGVSLLLRQAHIAYLEILAGLCFILSDAAIINSKQRLIRGAVFGTLPALFTVLLILFSPADRWALGFSLVATHSVTFFLVYKYAGKRLQRFVPLMTLCVLFAGWMLGALTVGRSELILASIPAEIFLINALLFLQNYPLKSPGNLATITGFILWACSSFFTIAWRENGSLDTLFPSIIYLPQFLVAIGMTLIVIEEDGAASRELAHEYEVLFNNNPNSLYIYDLRTLRFLSVNSASARMHGYSADEFRGKKLTDIVVGDALPEILDDIRTGQPRSNHRSLHARSDGTLIPLNVTSYNVRFRGRLARISLGEDQTEREQMLSQLIYQADHDLLTGLPNRHRLLQALDRAMTSITPAAPGCAVLILQIDRFEKINENYGHPVGDALLKQVTQLLSSALKPTDAIGRTGGREFTIVLAGILNGADAEGRAQNILELFADPLTIEEHSIEVAMNMGLAVFPEDSDDAVSLWRDAARAQARSRQLGVEGVVRLSRTHSLQAQEDSRIEAVMRRALQYGGFEVYYQPVLDANRKLCAFEALLRLREEDGTMVSPAVCIPIAESTGLIIPLGRWVLREVCRQLKTWQLNGLQVVPIAINVSALQIVLTNFCTDVDVALEEFDLKPSFIHFELTESSVMPRDSLALENMVKLATNGFSFSIDDFGTGFSSLDRLHKLPVSVLKIDRTFVSRMLDQNGTLPIVRTIISMAHALHLGVVAEGVETEEQLQMLAEMGCDQFQGFLFSKPVEAARAAILLSPRELSSGSLNALPGAAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY86</accession>
    <name>E8WY86_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">AciX9_1663</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580032.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1663"/>
    <dbReference type="EnsemblBacteria" id="ADW68713">
        <property type="protein sequence ID" value="ADW68713"/>
        <property type="gene ID" value="AciX9_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1663"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_0"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="259"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="409"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="499" mass="54958" checksum="A07D7A98136AC71C" modified="2011-04-05" version="1">MAQYVLSLDQGTTSSRAMLFDHDGKIAGMAQHEFAQHFPKTGWVEHDPMDILTTQLSAAVEVLARAHVRPRDVVALGIANQRETTIVWERESGKPVYNAIVWQDRRTADFCAKLHDEGHEETFRNKTGLLIDPYFSSTKISWILDNVDGARALAEQGKLAFGTVDSWLIWNLTSGKRHITDRTNASRTLLYNIVEDRWDADLLKLLRVPESMMPEVVWSSEKVGRVTTTLGLGDVEIAGIAGDQQSALFGQLCVNPGDAKNTYGTGCFLLQNIGDTFTLSKERLITTLTCTTNKKLQYALEGSVFVGGAVVQWLRDKMEFFEKSPDVEKIAASVDSSNNVVLVPAFTGLGAPHWDPYAGGMIIGLQRSTEIGHIARAALESIAFQVTDVLHAMQADTSVGLTTMRADGGAAANDMLMQFQSDLLGIPVERPAILETTAQGAAYLAGLATGFWNDVEEIAKTRPEGQLFIPRMDPAIARKRYLKWQDAVNRSKGWNKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY97</accession>
    <name>E8WY97_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580043.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1674"/>
    <dbReference type="EnsemblBacteria" id="ADW68724">
        <property type="protein sequence ID" value="ADW68724"/>
        <property type="gene ID" value="AciX9_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1674"/>
    <dbReference type="eggNOG" id="ENOG5031ZGH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747553_0_0_0"/>
    <dbReference type="OMA" id="DGRHYTA"/>
    <dbReference type="OrthoDB" id="1175728at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="44395" checksum="BCAD6C1C88588FDC" modified="2011-04-05" version="1">MSSSIDPSTFPNATTAADSITATSSPRRLLHYCLTVVLIPILAIPAFIQLGRSNFFLHHGASVWVRSNDAIFDIHDRDCDVLVYGDSTAMTGIDPEVVENHTGFRTCNIAVTNAVLAVTNNLTLNHYLAQNGKPRVLLVQLSPDDFQSENHAWHQTIYAEGLLELLRHGTPQQARDVLLSHPQESIAFAGYAIGFTAWYAIKDAWFHTTHLRPDEDSVTVRNGFFTPPSPARKSCEPAMSLISNDPAQAAFSRNLVADYREGYARNAGVVLVNVAPIPSCDENLAAYSAQLDGVTSNSLLPLPIGLFNDGRHYTARGSEVVSTLIAGELNTVANRNPSIDDRVPPTHMVAFLRRVHLRLHRTPRKSTPKFSSPGYDVLIFPPDVAPFEITPTLPSEDGTLSIPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP9</accession>
    <name>E8WYP9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0576"/>
    <dbReference type="EnsemblBacteria" id="ADW67647">
        <property type="protein sequence ID" value="ADW67647"/>
        <property type="gene ID" value="AciX9_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0576"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_1_0"/>
    <dbReference type="OMA" id="PPWDYRN"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="215"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="503" mass="55848" checksum="593650C6CB91155B" modified="2011-04-05" version="1">MHNPNIQQANGESGLVDVLLTHSYHLAHDAKQWRKMQPHPPLGTLYAATALRESGIAVAVFDPMFLEPISGFKQALLKHQPKLVVIYEDDFNFVTKMCLTHMRELARELALIAQSSGITVIAHGSDATDHPTMYLDHGVRYVLNGEAEQTLTELCTSLLHTGQPGVLPGLVHYGGPHHSLNVSSPAPKNPSWACLPRPARELIDLELYRAAWTAEHGFFSTSVVSSRGCPYRCNWCAKPISGDRFQLRSPEEVAAELHDLKSLHGVQHIWFSDDVFALDRRWIQAFATAVESYGTPLPFKIQSRADLMSETTVAALKRAGCAEIWMGVESGSQKILNAMSKGLQLPSVHAARKRLADAGIRACYFLQFGYPGEAWPEIKETIQLVRETQPDDIGVSVSYPLPGTVFFERVQEQLGLKRNWNDSDDLCTIHAAAYKNEFYHALRDALHAEVSTRFSTPDATCEALWQRVHALEPVSRNANVLTLPTVQDNFLPVTSLLSESGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW9</accession>
    <name>E8WYW9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1757</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580124.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1757"/>
    <dbReference type="EnsemblBacteria" id="ADW68805">
        <property type="protein sequence ID" value="ADW68805"/>
        <property type="gene ID" value="AciX9_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1757"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OMA" id="FQPGPWM"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="29114" checksum="D1493A3A0E385253" modified="2011-04-05" version="1">MSNPSTSSKGTALITGASTGIGAVYADRLAKRGYDLILIARNGKLLNELAASLSAATGRKVEALPADLTNKADLRKIEERLKTDTSITTLINNAGFGGVSTLLDSNVDEMENMIELNITALLRLTKAVVPGLLERKNGAIINIASIVALNPELLNGVYSGTKAFVLNLTQSLHKEVSSKGIQLQAVLPGATASEFWDRAGVGGHQNLPSEIVMSSEEMVDASLVAFDRGELVTIPALPNIADWDKFEAARIALAPNLSHKHSAERYGVRETAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ29</accession>
    <name>E8WZ29_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2921</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581259.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69944">
        <property type="protein sequence ID" value="ADW69944"/>
        <property type="gene ID" value="AciX9_2921"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2921"/>
    <dbReference type="HOGENOM" id="CLU_2522891_0_0_0"/>
    <dbReference type="OrthoDB" id="2029372at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9232" checksum="1A3A9679C2091937" modified="2011-04-05" version="1">MKKVENQRIDGETVALDGKAFVNCVLIDCVVEYSGSPFMLVDTELKGCRYVFFGAAKGTVHLLQSVGMMPFEPADWGEFPAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ49</accession>
    <name>E8WZ49_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="6" type="ordered locus">AciX9_2941</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581279.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2941"/>
    <dbReference type="EnsemblBacteria" id="ADW69964">
        <property type="protein sequence ID" value="ADW69964"/>
        <property type="gene ID" value="AciX9_2941"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2941"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_0"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14988" checksum="98846199A178EE7B" modified="2011-04-05" version="1">MNLTDPVADFLTRIRNSMRARHQKLDVPASKLKAEIARILKEEGYIANYKPTEENGMKVIRVYLKYGVNNESAIRDLQRISRPGCRVYLGKNEIRRVQGGLGISIMTTPKGVMTGRQARRENVGGEILCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ63</accession>
    <name>E8WZ63_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0594"/>
    <dbReference type="EnsemblBacteria" id="ADW67665">
        <property type="protein sequence ID" value="ADW67665"/>
        <property type="gene ID" value="AciX9_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0594"/>
    <dbReference type="eggNOG" id="ENOG50333GZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547236_0_0_0"/>
    <dbReference type="OMA" id="MGPANIA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="530" mass="56969" checksum="996DFFD1E1C44D98" modified="2011-04-05" version="1">MEGSMTIRRVCVAGVWLAGALGAARGQGYGAGSAPQAPAQVQGSAVDANGTRLETMSKLLMETQRQLEATQQQLNQLRSELEAMRGKEAAVSSGGASSSQGGAVPAGTLAEKVDHQQEELEVLQAEVKQHDQTKLESVSKYPVRVYGLMLFNAYSNAGVVDDADLPSAAIQRTPDLSHGSVGATFRQTLFGLSATGPRVFGARTSADLSVDFFGGSSYSYYATTNGSVRLRRADIRLGWGDRAEDTSVSRDEVHLGIDAPLISPLSPTSYATVAMPALAWSGNLWTWAPQLRYSHRFAISNDHPERNLQVEGGLWDPPVVGYAGSTAGRVLSAGEISRRPGFLGRVSAHGGSSAHPFSFGVGGYSDRQTFYEGQQIQMWAVTSDLQVPISRRFQLEGEIYRGRGLGGLGGGAYKDVLTGLDKVTGEQRSVGLNAVGGWVQWKTHLTGNTEANLMYGQDGGFARDFRTLNLTGSTYALEQSARTQMIVANVIYRPKTYLIFSPEYRRILSWKATGPAANANIYTLSLGYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ96</accession>
    <name>E8WZ96_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0627</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579026.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0627"/>
    <dbReference type="EnsemblBacteria" id="ADW67698">
        <property type="protein sequence ID" value="ADW67698"/>
        <property type="gene ID" value="AciX9_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0627"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047692_0_0_0"/>
    <dbReference type="OMA" id="CEQFLVP"/>
    <dbReference type="OrthoDB" id="912462at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="51844" checksum="9649A889076B2884" modified="2011-04-05" version="1">MIAAPPLHTFRDPSGSVELRTDAIYRTVHAPHDEELLSFLATPLAATLVAQGRLVASEQIETSPTVLRHPRIAFPSYPWEWSPAEWLAAAELTLNLSLDLLAEGWILKDATPLNVLFNGPDPIFVDVGSIARLDTTQPIWFAYGQFIRTFLLPMLAYSRLGWPLSATIARRDGYEPEDLYAALPWTARLRQPALSAVTLPQFLASKKSSAAPIAPPKKKQDDPELVQHILRKTFTTLLGHMRRATPAPHASTWTGYTNALTHYEQQDRDAKLTFVAEALAQSSPTRVLDVGCNSGVFSNLAFEAGAEVVSIDTDQQTIDHLSITLRNSGKKILPLVVNLAHPTPAAGWRNQESRSFLDRTQGTFDTVMMLAVIHHVLLREQIPLDRIADLCAAITTRHLILEWVPPTDEKFLELVRGRESIFAPITEAAFRTIFAQHFSILREQTLQNGRILFHFTKPEPSKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD3</accession>
    <name>E8WZD3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1773</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580140.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68821">
        <property type="protein sequence ID" value="ADW68821"/>
        <property type="gene ID" value="AciX9_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1773"/>
    <dbReference type="eggNOG" id="ENOG502ZKDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2129932_0_0_0"/>
    <dbReference type="OMA" id="DTHVEEH"/>
    <dbReference type="OrthoDB" id="2077697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234195" evidence="2">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="11622" checksum="4D956859BDF524C8" modified="2011-04-05" version="1">MRTSIFRGLLLTATLASTSFALAQTAGQDVKDAGHDTAHATKKVGHATAHGTKKAYHKTAHGTHVAAHKTADAGKDVGHDTKVGAEDVGHDTKVGAEKTGHGLHKLGDKVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH9</accession>
    <name>E8WZH9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1820</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580186.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1820"/>
    <dbReference type="EnsemblBacteria" id="ADW68867">
        <property type="protein sequence ID" value="ADW68867"/>
        <property type="gene ID" value="AciX9_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1820"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_0"/>
    <dbReference type="OMA" id="FAWFGGL"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="30827" checksum="6AF4F44717ED60FE" modified="2011-04-05" version="1">MYPYLNIGPLHLGTFGLLLWLAAVVAAVVLHRTFLRDGVDADALNVVAMVVISGVIGAKLWHELEDPAELVRAMKMVTAPGWGHPGQIVMEFLHWFQAGFAWFGGLLGGIGMLVIQGRGAKFKGTEIRVGGVRMLDLAAPAAFVGYGVGRIGCLTSGDGDYGRNTLGTFWGVHMKADALVPPSPRWALVLPTPLWEFVAAMVLAFVIWQVGKRMRPVGWLTGLYLVLSGTERFIVEFWRINPKLYFGHSMSNAQVAALGSVVVGALVMGAAMAKGTAWAPVGEAESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ0</accession>
    <name>E8WZJ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="5">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1831</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580197.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1831"/>
    <dbReference type="EnsemblBacteria" id="ADW68878">
        <property type="protein sequence ID" value="ADW68878"/>
        <property type="gene ID" value="AciX9_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1831"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_0_0_0"/>
    <dbReference type="OMA" id="EYCNGEA"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230108" evidence="3">
        <location>
            <begin position="29"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="483"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="686" mass="75042" checksum="772C36C0E55E8AAB" modified="2011-04-05" version="1">MVLKPLKFSLLCLTPAVLLGGACTLSGAQITESNPAANGPVHIKVSRPAHPQIIPEALFGSFLEPIRQSTYGGLWADAVVNPSFEDGLWSSNNIAQMLHERPELRRGSEVGLPLPWEPLERSQGSRYAPIRGDAANSYQSLLLMSLPGKEVGILQRLDLPVQRELTYKGNIWIKHVEGPETVSVSLRRRDHHDQTLASADIVASQATWTKYPFSLTLKPGNVAPLDPVDLVISLSNDARAQVDNVSLFPADAVDGMDPDVLNLARELHSPLVRFGGNFTSHYDWHDGLGPADKRISKLNLSWGIPEYNTFGTDEFLNFCRLINAQPQIALNLGTGHPQDAADWVRYVNEHWGDHKGGNLWELGNELWGDFQVGYPSMERVAAKTLATSQAIRAVDPHARLIATGADEDFFHDWDAQQLATPPDTFNYLSTHFVVNDNVQLAHASDQFRTQAALALPWGLADRMQAIKKQIADSGRPDVKVAFTEWLMVSDSHTGPHFSNLGGALFAGGFLNMVLRNSDAVGVSDMTGIIDFAGIVKKHGQAYGSPAYWVLRAYSSTHPHLLLAVQSDSPTYNVTHGIQRLPEISNVPYLDVIAAESADGKSLVLFCVNRHLTHAATAEVDLSAFGVKSGTARISTITGENILVENDEVNPNTVTPIMRSEAFKSKLTYTFPSKSVTVVEIPKDGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL8</accession>
    <name>E8WZL8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2969</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581306.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69992">
        <property type="protein sequence ID" value="ADW69992"/>
        <property type="gene ID" value="AciX9_2969"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2969"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="GTLRMHD"/>
    <dbReference type="OrthoDB" id="1770111at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230490" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26675" checksum="77463640CB2D2FDF" modified="2011-04-05" version="1">MRNIILTLVLLAPLAARAQTFAVASIRPTTIPVEFERDGSTKLTPGALHMRDVTVSTCIKWAYGVQRSQVSGPPWIESDHFDIEARSDAPATEAQTRLMMRALLADRFKLTFHQEKKELRGFALLPAKNGTKLHPVAVEEESFRQNSVNGMTARSLTMHDFTDFIAGVLEKPTVDQSGLPGKYDFKIDFTHYVPTEENGERPDAAAVINATLQGELGLKIEPQKVTVDVMVLDHVQPPSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN6</accession>
    <name>E8WZN6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2987</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581324.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2987"/>
    <dbReference type="EnsemblBacteria" id="ADW70010">
        <property type="protein sequence ID" value="ADW70010"/>
        <property type="gene ID" value="AciX9_2987"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2987"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_0"/>
    <dbReference type="OMA" id="WPEMVDN"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="8">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="372" mass="40388" checksum="D03985A5CC293FA9" modified="2011-04-05" version="1">MERRKVGILGATGMVGQRFIQLLHNHPWFEIAWLAASDRSSGKRYEDACRWKLDTPLPANIAGMTLMPNTPEGTPATELPKIIFAALDSDVAYELEPRFAAAGCAVISNSSAFRMTSDVPLVIPEVNADHLALIEKQSWRKDSGGYIVTNPNCSAIGLVLALKPIHDRFGIEKVFVSTMQAVSGAGYPGVASLDILGNVVPFIKNEEEKMQEEVGKLLGTLSGDHVAMLDAPLSAHCNRVAVEDGHTECVSLKLRTPATYEQMLEAWAEFAPLRGIHEGHPLPSAPDQPVEYVDQVDRPQPRLDRMRGKGMASTVGRLRPCSLFDWKFVVLSHNTIRGAAGAALLNAEILAMLDKLPGGKARSQNVPVALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS2</accession>
    <name>E8WZS2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ordered locus">AciX9_0663</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579061.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0663"/>
    <dbReference type="EnsemblBacteria" id="ADW67733">
        <property type="protein sequence ID" value="ADW67733"/>
        <property type="gene ID" value="AciX9_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0663"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_4_0"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="26179" checksum="32545AFADA3DDC81" modified="2011-04-05" version="1">MPIDFLKKPGVVAYLTAGDPDLATTRDIALAAIDAGADVIELGVPFSDPLADGPVIQRASERAVARGTRLSDVLGLAKELRAARPECGIVLFSYLNPVVKMGMRSFCAAAKAAGADGVLLTDMIVEEAGEYLAEMSTNGLAPVFLAAPTSPDARLKAIGEASKGFVYAISRVGITGTQDKVASDAPELVARLRKYTELPIAVGFGISNAAHVKAVGEFADAAIIGSALVALIEKTGPADAAKAVGEFIRGLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU3</accession>
    <name>E8WZU3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0684</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0684"/>
    <dbReference type="EnsemblBacteria" id="ADW67754">
        <property type="protein sequence ID" value="ADW67754"/>
        <property type="gene ID" value="AciX9_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0684"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009520_1_3_0"/>
    <dbReference type="OMA" id="SGAGGMW"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234210" evidence="2">
        <location>
            <begin position="24"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="514"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="636" mass="67926" checksum="8A814F5B52766BE2" modified="2011-04-05" version="1">MTSKLSAHRALLALLCAPLLLLAGCPGDPPTLDTTAPGSISPMATAPTNGKQTPAGTAQAAAAPNSTSAAQQPVQTGSPKADQIIKQAESSYNSGVANYRNNRLDAARMDFDFAIDTMLSSGLDLKTESPVADEFNRLLDAINSLEMAALKQGNGFSPKLDVAPLDAAEDITFAANPELVARLKNELNVTSDLPLVINDQVAGYIGVFSTSNSFRAHMAASLQRVGKYRGLIQNVLKEEGVPQDLIYLAVAESGFQPQVVNAHSGAGGMWQFMASTGTEYGLTRNGYFDYRFDPEKSSRAYARYIKALYNQFGDWYLAMASYNWGPGNIQRDVQRTGYADYWALYRLGLMPAQTRAYVPQILAAIIMAKNPERYGLDKLVPSPAVIYDTVSTSYSIDMHLVADVTGSTVPEIVALNPALLRLATPRDTSFDLHLPPGTKTLYNDRLKDIPEDRRASWRFHIVKAGETLDTIATALHARTADIAETNSITAQDPMSTGDELVVPVQTVTAAARPQRYTLRRGDTLVTVADQFNVSVEELRSWNNIASSGARAGRTIYVAEPIRLGSSGRSRGRGRGGRGGSKGRGRGGRASSGKASSRGGHAASAKASSHSASHSSGHASHAAAAPKSAKGKHKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X035</accession>
    <name>E8X035_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1885</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580250.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1885"/>
    <dbReference type="EnsemblBacteria" id="ADW68931">
        <property type="protein sequence ID" value="ADW68931"/>
        <property type="gene ID" value="AciX9_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1885"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_7_0"/>
    <dbReference type="OMA" id="VIAKYWG"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="539" mass="57592" checksum="FE652F05BD21069A" modified="2011-04-05" version="1">MANLFAKKTMNVLMAEADEHGSQTLERSLGPFSLTALGIGAVIGAGIFVLSGLGAKTAGPALMLAFVLSGFGCAFAGLCYAEFAAMIPLAGSAYTYAYATLGELFAWIIGWDLTLEYAMGASTVSSGWSNTFVEFLAIFHLKFPLWLAYDHWTGLKKAFESVGRKTVMAEHPDYASGTKAFSDALAALLAHPSAQLTASAHALLNAPKIGGIELGFNLPAFLIALLITTVLVIGIKESARFNAGIVVLKLAVVLFVLGLGSHYVNKANWGSDWHTFAPFGVGGIGLAAGLVFFSYIGFDAVSTTAQEAKNPQRDMPIGIIASLAICTLLYIGVAAVLTGMVYWPEINIEAPIVRAFLDRNLNSAANVITIGSLAGLTSVMLVMLLGQSRVLYSMAKDGLLPKGFFADIHPRFRTPWKGTILAGFIAAIVGSVTPIDDIGKMVNIGTLFAFVIVCIAVMVLRHKDPDRHRPFRTPLAWPIPVVPVLGILFNGYMMVELGAANWIRLVVWLLIGLVVYFSYSRKHSKVQAALLKQGLEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X052</accession>
    <name>E8X052_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1902</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1902"/>
    <dbReference type="EnsemblBacteria" id="ADW68948">
        <property type="protein sequence ID" value="ADW68948"/>
        <property type="gene ID" value="AciX9_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1902"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_0"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="181"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="297"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="357" mass="39164" checksum="7CD15E2ACEBA96B6" modified="2011-04-05" version="1">MASKPLILNPKSESTPVTLGIQSDTAFNEATKRLNGRDLCSISDLTVSEMAAIMELGHTVKESPEDFRHALDAKQMVLFFEKASLRTRLTFEAAINTLGGNAVFVDQTQSPLGERESIPDMAHNIERWMSLIVLRTYSHDTITEFAACSKVPVINALSDLEHPCQAIADFLTIEERFGSAQGLHFAYVGDGNNVCHSLMLTAAQLGANCYVATPKGFVPKLDIIHKAIEISEQTGGSITLLNDPIKAVTGADAVYTDVCTSMGFEHEATKRAPIFKPYQVNEQLMSHAQPHAVFMHCLPAHRNAEVTDAVLDGPQSVVFDQAENRLHAQKALLLMLLGGGKRLQSSRERNQQGRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X060</accession>
    <name>E8X060_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3020"/>
    <dbReference type="EnsemblBacteria" id="ADW70041">
        <property type="protein sequence ID" value="ADW70041"/>
        <property type="gene ID" value="AciX9_3020"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3020"/>
    <dbReference type="HOGENOM" id="CLU_1675441_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="17253" checksum="88085FE5EDD8B69F" modified="2011-04-05" version="1">MEFVRPTRNENVRTLAGVCLILVALALPGISIKSGGGWGPSGVEVGWWCARQANLMLLLLPRTFLHPRPGSGVIFLFGLTGLINPLLMFSLIPNRYWQFLCASVIVACLAATWLAIWVSSLTPLPGHFLWVAGVLLIVSREWFGEPWASWRAGRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L5</accession>
    <name>E8X0L5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein SET</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1920</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580285.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1920"/>
    <dbReference type="EnsemblBacteria" id="ADW68966">
        <property type="protein sequence ID" value="ADW68966"/>
        <property type="gene ID" value="AciX9_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1920"/>
    <dbReference type="eggNOG" id="COG2940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020840_4_1_0"/>
    <dbReference type="OMA" id="KCRGTML"/>
    <dbReference type="OrthoDB" id="1675945at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16673" checksum="247A2BFAAE3A4AA3" modified="2011-04-05" version="1">MMPGLVVRSSEIHAAGCYTTKAIRKGRRVCEYTGPRMTKEVADERYADRFVTYLFGYGTKEMVIDGFGTAMFMNHCCNPNCETEEEDERIFVVALRDIAAGEELTYEYNLYDSDEATQDCYCGAENCRGTMFSVAEMERRAGLKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P9</accession>
    <name>E8X0P9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1954</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1954"/>
    <dbReference type="EnsemblBacteria" id="ADW69000">
        <property type="protein sequence ID" value="ADW69000"/>
        <property type="gene ID" value="AciX9_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1954"/>
    <dbReference type="HOGENOM" id="CLU_2601149_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8689" checksum="72D2271A82DC8C59" modified="2011-04-05" version="1">MANTSFVKTANERRYISKGDNAADGSPLLEAPHPLSLSMNAHVIFANAVGDPDAKALVEEWRPRFIIRAATSQEVEAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U7</accession>
    <name>E8X0U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3115</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581445.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3115"/>
    <dbReference type="EnsemblBacteria" id="ADW70131">
        <property type="protein sequence ID" value="ADW70131"/>
        <property type="gene ID" value="AciX9_3115"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3115"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484645_0_0_0"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="562" mass="63092" checksum="1FC3FCE5E5D89E7D" modified="2011-04-05" version="1">MQDSSPFQYIAIDQIFESKTNPRQTFDQVKLEELAASIKHHGLIQPIVVRPKENGFEVVAGARRYRTSLLAEEFSVPAHIKELNDAEAVEWQLVENSQRVDIHPYEEAQGFQRLLDVPGYDVAALVEKSGKSTSHIYARLSLLQLIPKVAEAFVEERITASHANLIARLPQEHQADAFENCWRKDWQDKEAHLLPAKHLSAWIQSNLYLNLAEAPFDREDTTLKPEAGACVACPRGSGFNTSLFADVQGDQCLDGACFQAKVTAHIDREVAARPELVQIETAWRSSKEQRPGTLNKNQYRELAEPDNPDTEPPCPSAKAAIIVFGKNVGRTVTVCLDAECPVHTNQAHHTEEEDVEPPPVMAEAPEQETEEEAAQRKAEHEQRMAEYKAEQQRKEDERKAEFERQQKEYEAEQARREKLRKARAATFERIVETAPTSFSQEQLRLFLRLIVENMAYQLHEEVAHHFASGEEDTEQGDDEVVLAALANTADDKLISFALRLVLADNLEIPREGQNDTLSEAEALFAPKPAKPKKTPSSPSSLVKASAMKSVKVKKSAESQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X151</accession>
    <name>E8X151_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0849</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0849"/>
    <dbReference type="EnsemblBacteria" id="ADW67917">
        <property type="protein sequence ID" value="ADW67917"/>
        <property type="gene ID" value="AciX9_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0849"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_15_4_0"/>
    <dbReference type="OMA" id="THADANP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13288" checksum="0E8C101A74DD11B4" modified="2011-04-05" version="1">MTIKLAIPILPAADVQTSLDWWTTIAGFTRTHADANPPTYAGIACDNTHLHIARITDPIVARTVGEQTMVRVVVEDIQAFYAAYKQRGGIIHPNGDLSTKPWGTTEFAAHDPNGICVTFQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X159</accession>
    <name>E8X159_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579250.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0857"/>
    <dbReference type="EnsemblBacteria" id="ADW67925">
        <property type="protein sequence ID" value="ADW67925"/>
        <property type="gene ID" value="AciX9_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0857"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097817_0_0_0"/>
    <dbReference type="OMA" id="WYSRRQF"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="47"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="29447" checksum="C5B1A912B04965DC" modified="2011-04-05" version="1">METPYISKPVLGFFRRIVRGYFRRHFRAVRVRGAERFAAAGTDGRPLIVYANHGSWWDPMVQVLLAAELMPGRKHYAPMDAAALERYGIFKRIGVFGVEMKTARGAAQFLRTGLRVLREGGVIWVTPQGRFADARERPLEFKPGLAALAAKVAGGCTVIPLAIEYPFWDERLPETLLLFGEAVTVEGDSAEAVEGRLKWALQRAMDELQELAIARDARAFTVLRKGRVGTGGFYELGQRVWARVRGRRYQAEHTVMPEEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X171</accession>
    <name>E8X171_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0869</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0869"/>
    <dbReference type="EnsemblBacteria" id="ADW67937">
        <property type="protein sequence ID" value="ADW67937"/>
        <property type="gene ID" value="AciX9_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0869"/>
    <dbReference type="HOGENOM" id="CLU_3025928_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="55" mass="5386" checksum="634072DFD70D9330" modified="2011-04-05" version="1">MRAGAKAPLCYVSIDGGLKPPSNPNGNGNGNGNGNGNGNGDCDCNCDCDGDCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E2</accession>
    <name>E8X1E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2051</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580413.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2051"/>
    <dbReference type="EnsemblBacteria" id="ADW69096">
        <property type="protein sequence ID" value="ADW69096"/>
        <property type="gene ID" value="AciX9_2051"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2051"/>
    <dbReference type="eggNOG" id="COG3405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037297_0_0_0"/>
    <dbReference type="OMA" id="IRVYLWV"/>
    <dbReference type="OrthoDB" id="636673at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="405" mass="43754" checksum="509A1F7A8DBB7488" modified="2011-04-05" version="1">MLSYDQGVLTLFSSKNWSGAGQRKTLSGIAALAVMLTGVQACRAQKPWPLWDAYAKRFLDDQGRVIDRSAGDRTTSEGEAYSMFFSLVDNDRPRFDKLLNWTVANLAGGDLTLRLPAWSWGKNAAGEWKTIDSNSAADADLWMAYTLLEAGRLWKEPRYETLGRLMATRIAKEEVVVVPELGTVLAPGPKGFHPDDQTWLVNPSYMPPPVLVGLAKRAPNGPWKAIAKTLPAVTGGAISHQFAMDWVSAGSAGIHPSAPPSQPTTGTQQTQASGSYDAIRVYLWLGIAEPGTAGLHNLLGRVSGMGGYLGTATTPPLEVSPEGTVVRSDAPVGFSAAMIPYLSSIGAKAAAKTQADRLVATKDPESGLYGRTMEYYDQNLALFSTGWSEHRYLFERDGALKVSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N2</accession>
    <name>E8X1N2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_0883</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579275.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0883"/>
    <dbReference type="EnsemblBacteria" id="ADW67951">
        <property type="protein sequence ID" value="ADW67951"/>
        <property type="gene ID" value="AciX9_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0883"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019564_0_1_0"/>
    <dbReference type="OMA" id="SKFARMP"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017232">
        <property type="entry name" value="NtrY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045671">
        <property type="entry name" value="NtrY-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19312">
        <property type="entry name" value="NtrY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037532">
        <property type="entry name" value="STHK_NtrY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="349"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="555"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="793" mass="86458" checksum="6DAB64636CC3686F" modified="2011-04-05" version="1">MTTTAHQRKVASIIFGACGLLLFAAFVTLNAWDPKFLKPATTEQIFVYTALSALAFLLFLTVLLLLVRNVLKLYADQKSRVMGSRLRTRMLWGAVLVSLVPISFMFSFSYLLMNRAVERWFSQPVTTMRDNSNRMALQLAQYTASNARVEAESIASALPELLPINPANRTSITKLLSLHQITLQGGFAIVFQDGRPISVFHLPAKGSAQPGAKDWLPDPANADQLDDEPPTSEPVPGAARPVPKPTRVTDILALAQRSDEPMYTSGESDFSLGTAAVIKKGSSAVTVVVGLPLPAGMSANMTSLRTAADAYWRLARSRREVRNLYMLLLLMITSLALFASSWLALHLSKQVTKPVEALADAMAFIAAGNYSHRVREIATEELGDLVRSFNHMAQDLEGSRAQVEASTALLSAANSALEARRSELETMLQTIPNGVATIDAERRIVLANRALTEMMDPGGQQPFRGLAIEEIFPADLMESLDRLMRRSHRMGSAAGEMEMPSPSGPLNLLATVALLETSADRTGAREHLGYVIVLENATELLRAQKQSAWKEVARRVAHEIKNPLTPISLSAEQIGRHIDRLETTIEETNTTSPSIAVIRRCSEVISASVESMRGLVDQFAALAQFPTATPRPADLNTIVENSLALFAGRMQDIRLTLKLAQDLPLVLADPEAMKRALGNLIDNAVEAMQGSLLREMRLTTSLLDSGMIELTVTDTGTGLTDEMRERLFLPYFSTKQRGTGLGLAIAAKIIQEHQGTIRAEKHEPAGAIFIVELRPASMSDSEAADQPTLTATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z7</accession>
    <name>E8X1Z7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ordered locus">AciX9_2114</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2114"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="ADW69158">
        <property type="protein sequence ID" value="ADW69158"/>
        <property type="gene ID" value="AciX9_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2114"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_0"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="203"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="230"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="57346" checksum="AAD068B4D7157C36" modified="2011-04-05" version="1">MDTPTNISASTSTIVILDFGSQYTQLIARRIREFNVFSVVLPCTTPLDQIKALAPMGLVLSGGPNSVYDPDAPAADPALLKMDVPILGICYGLQFIVHHLGGKVESAAQREYGHASVEVIRETKLFAGLPGTLDVWMSHGDHAVALPPGFERTAETANAVAGIADEDRRIWAVQFHPEVAHTRQGMELLRNFALDICGCEANWTPEHFIQTTIERVKAQVGTGHAICGLSGGVDSSVAAVLVARAIGDRLTCIFVNNGVLRKDEFAKVHATMREQLGLNVVAVDAADRFLTKLAGVTDPETKRKVIGGEFISVFDDEAKKIFEAEKSAGEEIAWLVQGTLYPDVIESSSVKGPSQTIKSHHNVGGLPADMKLKLIEPLRDLFKDEVRRIGRDLGMPDEIIERQPFPGPGLAVRILGEVTAERVAILQEADAIVVEEIKAAGLYRKVWQSFAVLLPVKSVGVMGDQRTYANTCAIRAVESEDGMTADWAPLPYEVLRKISSRIVSEVRGINRVVYDITSKPPGTIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X240</accession>
    <name>E8X240_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3272</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3272"/>
    <dbReference type="EnsemblBacteria" id="ADW70283">
        <property type="protein sequence ID" value="ADW70283"/>
        <property type="gene ID" value="AciX9_3272"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3272"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_0_1_0"/>
    <dbReference type="OMA" id="AIQEEWP"/>
    <dbReference type="OrthoDB" id="1421045at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="42309" checksum="C8BFBDAE2200ED71" modified="2011-04-05" version="1">MDAKTTLWIHRTVNPHLSNSNAAPENLMSPTPGNTSAKLDPSHSDAAPVDPKDHRVGATHPLEQHIWDRVSSTPLHNLWDFQGASPLAIAKRTFHSFNEDNLLSRAAELGYYFLFALFPTLITASAILGLVVRNSTLYLKLLNYLALVVPADAFKLVLETFTQTTTHSSGSKLIFGLAAGLWSASVGFSAIQDTLNIVYKVKETRPYWKVKGAAILVTVLLSIIVILILGSMFTGSFVAHWLYTHIAQHQLALAVNVIVRFIAWSCAALLCVLLFAVIYYFAPDVKNKHWRWFTPGAAVGIGGWVLASVILRVYLHYFNSYSVTYGSLGAVIILLTWFYMTGLMLLTGAEMNSEIEAAAAECCLKAEGKIPEQATTDASAPIRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L0</accession>
    <name>E8X2L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2190</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580550.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2190"/>
    <dbReference type="EnsemblBacteria" id="ADW69234">
        <property type="protein sequence ID" value="ADW69234"/>
        <property type="gene ID" value="AciX9_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2190"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_3_0_0"/>
    <dbReference type="OMA" id="HFLPMNI"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="72" mass="7494" checksum="76F006F408705D1A" modified="2011-04-05" version="1">MSLTLTLNGQAQSLEALEDGAAMDVVVAALGLKADRVAVELNGEIVSRKRWGEQGVRGGDKLEVVHFVGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W5</accession>
    <name>E8X2W5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell surface receptor IPT/TIG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1036</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579422.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1036"/>
    <dbReference type="EnsemblBacteria" id="ADW68099">
        <property type="protein sequence ID" value="ADW68099"/>
        <property type="gene ID" value="AciX9_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1036"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800828_0_0_0"/>
    <dbReference type="OMA" id="QIFVFAT"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="35628" checksum="52F8F416B3B29B94" modified="2011-04-05" version="1">MPTLTQAAPHAVMPGGELHLTGNDLGPGVEVEIAGVTAHVELARSTQVIVRVPEGILPGQVFATKDGIHSNALPVRIAVPMAENLHPVANPTVDATGTVYATLSGSRGQQTPVSIFRIPPAPEGKTHELRPYVRNILNPTGLAFGPDGLLYVSSRADGIIYKVGSSGVAQVYAEGLGIATDIVFDRVGDLYVGDRSGTIFKIRSASEGRSQETFVFATLEPSISAYHLAFDSKGTLYVTGPTTASHQIIHAIDHAGSASVFYRGLGRAQGMAFDTGDNLYVAASLAGNRGIVRITPSGAADLVVSGANLIGLCFLPDGRAALATRDAIYEVELGIQGLALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z0</accession>
    <name>E8X2Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1061</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579447.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1061"/>
    <dbReference type="EnsemblBacteria" id="ADW68124">
        <property type="protein sequence ID" value="ADW68124"/>
        <property type="gene ID" value="AciX9_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1061"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_0"/>
    <dbReference type="OMA" id="FAAWDTY"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23814" checksum="F495A7776808D491" modified="2011-04-05" version="1">MTTVTERLAWRYATKKFDATKSVPTEKLERIIEAIRLAPTSSGLQPFQLFVITNPDIRAKIRAVSWNQAQVTDSSHLLVFAAWDNITPERVHMMFDLTNDIRGFKNEGWESYRQQLLGIVAARGTEANYQAAARQAYIALGAALIAAAFEEVDATPMEGFDPAAVDEILNLKSKNLRSVVMLPLGYRAAEGDWLANLKKVRRSRENFVTEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X356</accession>
    <name>E8X356_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580596.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2239"/>
    <dbReference type="EnsemblBacteria" id="ADW69280">
        <property type="protein sequence ID" value="ADW69280"/>
        <property type="gene ID" value="AciX9_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2239"/>
    <dbReference type="HOGENOM" id="CLU_2682634_0_0_0"/>
    <dbReference type="OMA" id="DYCETEL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="74" mass="8162" checksum="1398BA3CBED6E37A" modified="2011-04-05" version="1">MIQIPLTPEAFAAKSQELAEKHNITLTGHEGTLSKSGVTAGYKYEVGLLTVNILEKPFFVSTDYCETELKKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X362</accession>
    <name>E8X362_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2245"/>
    <dbReference type="EnsemblBacteria" id="ADW69286">
        <property type="protein sequence ID" value="ADW69286"/>
        <property type="gene ID" value="AciX9_2245"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2245"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793774_0_0_0"/>
    <dbReference type="OMA" id="YRWRSEY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14838" checksum="A0C4E65DB875C027" modified="2011-04-05" version="1">MARGKKHTAEPIVNLLRQVEVGVANGKSLPQACKEAEIVEQTYCRWRREYGGLKVDQARRLKDLEQENAKLKRLVANLSLEKLVLKDRGGKLLSPERRRCAVSHAREAHGAERAACVPCGGAATGHATLSTDTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X385</accession>
    <name>E8X385_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580625.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2271"/>
    <dbReference type="EnsemblBacteria" id="ADW69309">
        <property type="protein sequence ID" value="ADW69309"/>
        <property type="gene ID" value="AciX9_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2271"/>
    <dbReference type="eggNOG" id="ENOG5033VKA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219218_0_0_0"/>
    <dbReference type="OMA" id="PIASGWI"/>
    <dbReference type="OrthoDB" id="1866958at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233618" evidence="1">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="25272" checksum="4E2A56D86557073F" modified="2011-04-05" version="1">MPAKHLRRIVCLSATLASTLPCIAAPPARACRQAVIEGEVTAGQPFLKAIGGNLALYLQPIASGWIIRIVPASGPRGEHDYAELATPPYNSVTALSLSTDFAFRAQDAVGWNPRRFHFATNPQTFSQLLHAYQAFPPPPASPPASAEQQLASLLPLTSQGTLRILDARMIPGTADQTPMAATVASHFASTAHTVDQLQTPTPLGKLLWLKFRTELDLPPAFVPAPGLKIQPSVCSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M4</accession>
    <name>E8X3M4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ordered locus">AciX9_1152</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579538.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1152"/>
    <dbReference type="EnsemblBacteria" id="ADW68215">
        <property type="protein sequence ID" value="ADW68215"/>
        <property type="gene ID" value="AciX9_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1152"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_1_0"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19731" checksum="5480331B07A83ECE" modified="2011-04-05" version="1">MAGQNVFAPRYAQAFAEVAASANLDVNLAQQQMKDFAGTLADSPQLLEILADPSLSSEKKLSILDAVAEKIGMYREVRNLLAVIMDHHRLHDLQEIVAAFHQVAEAGAGVVEAEVVSSRELNPDDRAQLEWEISKLAVSRVSVTYTQDPTLLGGAVVKIGSTIYDGSVKAQLEQMKQALTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N7</accession>
    <name>E8X3N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal subunit interface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1165</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579551.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1165"/>
    <dbReference type="EnsemblBacteria" id="ADW68228">
        <property type="protein sequence ID" value="ADW68228"/>
        <property type="gene ID" value="AciX9_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1165"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140394_0_0_0"/>
    <dbReference type="OMA" id="CTSTHII"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13490" checksum="51CABE3E92861326" modified="2011-04-05" version="1">MNVEYTGRNTTISPKWKQMADQELGRIDKLLGRSVGAHVIFTEDKYRMCVEVTLVAANETLVATNCQDTDMLVALHDALKKIESQAIKHKERRMTVERHGKPDSAEPLIELAEVPQSSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U6</accession>
    <name>E8X3U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="2">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2337</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580690.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2337"/>
    <dbReference type="EnsemblBacteria" id="ADW69374">
        <property type="protein sequence ID" value="ADW69374"/>
        <property type="gene ID" value="AciX9_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2337"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_3_0"/>
    <dbReference type="OMA" id="QQAWDRT"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24215" checksum="323EC858AFBE86DE" modified="2011-04-05" version="1">MGMIKITAADGHELGAYVAAPDKPIGAVVVVQEIFGVNKSIRGVADDFAKAGYLAIAPALFDRYERDLELTYVGEDLQKAFGLYGKLSPDTALLDIAAAFKEVEKTVEGVAVMGFCYGGLMSWLSATRAEKLGIDPACTVGFYAGGVGSVATEEPTCPVMLHFGLADSHIGADQREAVKAAHPEVKVYEYEGAGHGFFNVDRADYAPEQAKLAWERTLEFLKENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U9</accession>
    <name>E8X3U9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Flagellar hook-associated protein 1</fullName>
            <shortName evidence="7">HAP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgK</name>
        <name evidence="10" type="ordered locus">AciX9_2340</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580693.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2340"/>
    <dbReference type="EnsemblBacteria" id="ADW69377">
        <property type="protein sequence ID" value="ADW69377"/>
        <property type="gene ID" value="AciX9_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2340"/>
    <dbReference type="eggNOG" id="COG1256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012762_1_0_0"/>
    <dbReference type="OMA" id="DQYEVAQ"/>
    <dbReference type="OrthoDB" id="1815809at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="9">
        <location>
            <begin position="406"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="469" mass="45995" checksum="382FED28D6CF6009" modified="2011-04-05" version="1">MGSLSSLYDLSRGALQADQVALTTTANNVANQNTVGYTRQVVTFASGADRVTLSDGAIASANAPEATVSSARDRVLEQRVQQQTQLQAGTSAQATALSQLEAVFSISGSSATVGSTQIGTAIDGFFSSLTALTSNPSDSSTRQAVLTAAGTLAQAFNAGAQQISSVAAGINSGVASSVTAVNSLTATIAGLNAQIQSQSPNTDAGALEDQRQTAIAQLSQYIGLDQISTESNGIALTTASGATLVSGTKSYDISSAVVGGSAKIYDSTGADITAGITGGSIGGQLAAQGGALTTASTALDALAYRIATAVNTQNEAGLNGSGSAAGAIFTVPSSSAGAAGALVVSATSVNAIASAGSGEGVTGNTNALALAAIATGTDANGATIDGSFAALLSQVGSSSSSLQAQSTAQQATLTALTSQRDSLSAVSLDEEAANLSQYQRSYDAAAKLFSIVDSVTVTALNLGEEVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X446</accession>
    <name>E8X446_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67106">
        <property type="protein sequence ID" value="ADW67106"/>
        <property type="gene ID" value="AciX9_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0015"/>
    <dbReference type="eggNOG" id="ENOG502ZXJ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2129930_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="11985" checksum="FAF34314C34F7239" modified="2011-04-05" version="1">MVAGIAAYFAVHALARHGWWGDGSDFMPEVFQCLLPFIAFGTTVMAGLSVLTGYGLLTRRSWGRPLAIIMAILSLIKIPLGTALGIYTLWVLGSKAGGAEYEGLAAAEEGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X497</accession>
    <name>E8X497_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome_C7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0066</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578486.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0066"/>
    <dbReference type="EnsemblBacteria" id="ADW67157">
        <property type="protein sequence ID" value="ADW67157"/>
        <property type="gene ID" value="AciX9_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0066"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077373_0_0_0"/>
    <dbReference type="OMA" id="PVWCAET"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="3">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="34136" checksum="48F42A358BD94B6E" modified="2011-04-05" version="1">MAQVFDRSSNALARASLVLTGLIVIALGVGLNSLQRSPWVTRQGQRPDQPVPFSHKHHVEGLGLQCQYCHTSVEKSSYAGIPPTKTCINCHAQIWTNAELLEPVRHSWATGESINWIRVHDLPDYVYFNHEIHVNKGIGCASCHGRVDEMPLMYQENSLQMEWCLNCHRNPSVNLRPTSEIYNMAWGGPTSDKPVWCAETKNTVRTDVPTAQGVSCTTKDPSGNGPEIASLQELSVRPRSMGKAAAGSGTEQDPHASSPGVTASDAPPADLLPAGALNYKKFTTQNDLGHYLNGMYHIRGGNELSSCEVCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D0</accession>
    <name>E8X4D0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ordered locus">AciX9_1194</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1194"/>
    <dbReference type="EnsemblBacteria" id="ADW68257">
        <property type="protein sequence ID" value="ADW68257"/>
        <property type="gene ID" value="AciX9_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1194"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_0"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="176"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="50352" checksum="9BE589690B0F9167" modified="2011-04-05" version="1">MVSMLDLAFVRTNLAQVEEKLRTRGLDPAVALANFAAIDTARREAITRSETTKAERNRLSNEIQALKKSGQDATSQMDAVKALKAEGEGLEVAAAEADTRLRDMMQTVPNLPADSVPLGADEHANQQVKTWGTIPTLDFTPKPHWELGEALGVLDFERAAKITGARFVVQFGQGARLERALANFMLDLHTRQHGYTEVLPPAMVNSKSLFGTGQLPKFAEDLFHCDDKGPYEPGNYQDSDHWLIPTAEVPLTNIFRDETLDEADLTISFCAYTSCYRSEAGSHGKDTRGLIRQHQFQKVELVKFTRPQDSEAEHENLTRNAETILEQLGLPYRRMLLCTGDMGFSSAKTYDLEVWLPGQSTYREISSCSNFESFQARRANIRYRPLVDGKPAKKPDFLHTLNGSGLAVGRTYVAILENYQQADGTIRIPEVLIPYMDGETVIGRQQGPWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F6</accession>
    <name>E8X4F6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ordered locus">AciX9_1220</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579606.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1220"/>
    <dbReference type="EnsemblBacteria" id="ADW68283">
        <property type="protein sequence ID" value="ADW68283"/>
        <property type="gene ID" value="AciX9_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1220"/>
    <dbReference type="eggNOG" id="COG2160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_0"/>
    <dbReference type="OMA" id="HMLEICP"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="356"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="483" mass="52939" checksum="8FDF331D62C89DFA" modified="2011-04-05" version="1">MTLDHLEVWFVTGSQHLYGAEALAKVAENSQKIAASLNAETGIPVKVVFKPVLTTADEITELCREANNVKSCIGLVLWMHTFSPAKMWIAGLKSLTKPFLHLHTQFNRELPWATIDMDFMNLNQAAHGDREFGFITSRLKLPRKVVVGFWQDAVTVAEIAAWTRAAAGWYESQNLKVVRFGDNMRDVAVTDGNKVSAEAVLGYSVNGYGVMDLVDRMNQFGDAEVDQLVAEYRDAYTITKEHDRVSTLRSAAKIELGIRAFLVEGGYGAFTDTFQDLHGLDQLPGIAVQRLMADGYGFAGEGDWKTAALVRTMKVMALGMTGGTSFMEDYTYDFSGTPKILGSHMLEICPSIAADKPSLEVHALGIGGKGDPARLVFTAPDGPAVCASIVEMSEGYRLIVNEVDVIQPEQALPKLPVARAVWVPRPSLKVAAAAWIYAGGAHHTCFSQALTTEHLEDFAEIAGIEMIVIDADTKLRELRRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R3</accession>
    <name>E8X4R3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ordered locus">AciX9_3548</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581863.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3548"/>
    <dbReference type="EnsemblBacteria" id="ADW70552">
        <property type="protein sequence ID" value="ADW70552"/>
        <property type="gene ID" value="AciX9_3548"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3548"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_0"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="28296" checksum="9B947BC73A9779BD" modified="2011-04-05" version="1">MSTVLDKILARTTLSVQARQAAADLPALERRAAAHIPAGFAANLRAVAQTRPAVIAELKKASPSKGLIREDFRPTELAASLEAAGAAALSVLTDEEFFQGSLAYLEAARAAVRIPLLRKDFMVAPFQFLEARAAGADAILLIVAAHDDATLKILAASARQYQLDILCEVHDREELERAKDLGADLIGVNARDLKTLDVKHDNHMALIEHLPADTIRVAESGIRTPADIDRLLAAGYNAFLIGETLMREPDPAAVLATLLGTAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R7</accession>
    <name>E8X4R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3552</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581867.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3552"/>
    <dbReference type="EnsemblBacteria" id="ADW70556">
        <property type="protein sequence ID" value="ADW70556"/>
        <property type="gene ID" value="AciX9_3552"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3552"/>
    <dbReference type="eggNOG" id="ENOG503395V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2601153_0_0_0"/>
    <dbReference type="OMA" id="MHTAVER"/>
    <dbReference type="OrthoDB" id="2061538at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8949" checksum="98CB35927712195B" modified="2011-04-05" version="1">MPYLYIDKVLNELRDELLSAMHAAVDRELRQGRVDVGKLYRAFTRAAANQMANPVLVSDKCIETNTSRPKKGSKVRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z1</accession>
    <name>E8X4Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578512.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0094"/>
    <dbReference type="EnsemblBacteria" id="ADW67183">
        <property type="protein sequence ID" value="ADW67183"/>
        <property type="gene ID" value="AciX9_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0094"/>
    <dbReference type="HOGENOM" id="CLU_879308_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="33407" checksum="D6360D692564674E" modified="2011-04-05" version="1">MSSTSSRFGLTAFRNLYLIGPALLLATGCGPMDYQKPIQQFSDASSIVAASATLFLNNENAIEQEALVERLAFEAKPIDVTAIEQSVVISANEIKIRTKSILVLSSFTANLATLASGKAGTAVTQNAADLSSSMKKLATDAGGLPNSKLDNAHFAGLASAAAEAMGAVAKAIIDKKSRRDIEKTIQDNEKPIESLIELLGSELTLAYERQKSAVGAQSIYLSQAYSAELNTAVPNVERRISIAGQINAYRRLQGDLQAADPAPAVAKMRASFVALVAYSRSNRDPQSLTALWKAVQDFSAAAQPLAQAIQSLITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X543</accession>
    <name>E8X543_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1245"/>
    <dbReference type="EnsemblBacteria" id="ADW68307">
        <property type="protein sequence ID" value="ADW68307"/>
        <property type="gene ID" value="AciX9_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1245"/>
    <dbReference type="HOGENOM" id="CLU_3168637_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5313" checksum="120168031BEAB874" modified="2011-04-05" version="1">MHLDRGFLNSMEGHHLIAAYALVVLIQGGYVGWIAYTWRKIGKPQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X552</accession>
    <name>E8X552_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68316">
        <property type="protein sequence ID" value="ADW68316"/>
        <property type="gene ID" value="AciX9_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1254"/>
    <dbReference type="HOGENOM" id="CLU_2601148_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8662" checksum="9885647624DB3A20" modified="2011-04-05" version="1">MPRSHFCVNKSAPIVEYQYGPRHTMIVLTETVTPPPASIKKEFPLFTDIALALALLSVIVAPALIAMRVTGSSQQRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X588</accession>
    <name>E8X588_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579675.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1290"/>
    <dbReference type="EnsemblBacteria" id="ADW68352">
        <property type="protein sequence ID" value="ADW68352"/>
        <property type="gene ID" value="AciX9_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1290"/>
    <dbReference type="eggNOG" id="COG5429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065609_1_0_0"/>
    <dbReference type="OMA" id="LPIDYWD"/>
    <dbReference type="OrthoDB" id="1505781at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010634">
        <property type="entry name" value="DUF1223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057">
        <property type="entry name" value="PTHR36057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06764">
        <property type="entry name" value="DUF1223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233693" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="26251" checksum="6BF2377956D8D891" modified="2011-04-05" version="1">MKQVAIWLAAVSISGAAWGQMTPAIRPNAVLVELFTSEGCSSCPPADAVLAKLNATRGAGEDGPLIVGLSEHVTYWNRLGWADPFSQELFTSRQNGYGSRMRLDSVYTPQVVVDGTRELVGSDEAGILRAVQASGKAGGVGLKIASAVAGHDGVKVSFEVTGAVPKGAEVYAVVAQDMASTKVQRGENAGRTLKHVSIARNLVRVGALDRAGSREVELPLPEMVEGGRHLVLFVQEAGLGRVLAVEEHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B3</accession>
    <name>E8X5B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579700.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1315"/>
    <dbReference type="EnsemblBacteria" id="ADW68377">
        <property type="protein sequence ID" value="ADW68377"/>
        <property type="gene ID" value="AciX9_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1315"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358518_0_0_0"/>
    <dbReference type="OMA" id="HTWRNEA"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230241" evidence="1">
        <location>
            <begin position="18"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="746" mass="79911" checksum="08E111B710FB01AB" modified="2011-04-05" version="1">MRLLPLALLSLAVPAHAVVVQGTVTGPFGQPVPGARIQLIQLGAGTRSVADAVSGVDGEYEIRTDVAGRFLLLTASPYFAPQIGVDFYAGRTDLVTRDITMDPSSLTPLKTTLPNNLDTPLAQLSTLLTQLPADHLLTPAQIPSQLPFAPATFLVQTGQQGQPAALYLRGANPDANAVLLDGQPIQSLGGAFNYGTFSTTGLAALASSAAVQLAPGPNPTEAPAAEAGTIAFATPRASTAHPALDYSGDAGNLHAWRNEAAVTLTRRRADLFAAYSHFNISNALSNDQFNTGTAALNAGYNIAANTSLRATLRQETSAAPLPIAYDLGLTPSTRDAAQNLYGTFTFDTRTAGGWHNQLRYGLVRRREQLFVYTEPAPRLVTLRGANGSTITGLATYPNLPARADQATNRDQATYQTDYPLTQWLTGLFTFRYQNERALDAQAGLAPSQQQGTPAPSFSSSFNLTNLTFATAFKAEYKHRLFGEASGDLNHSNFIGFTGSPRLGLTYTPVYLGARRFRGTSLHATVAASSREPGLPEIVSKVTIPARSRTLDLAVDQNILGRKLILHAAYFHNQFSHQTEQLAPNALALSGTQAFRTQGFTTELRYQPLARLFIRGGYTYMASLIEQSAATTSLYTPVVGSRPFRRPANTGYFTIQYTGRALSAGLAASLAGRSDDSTFTPTLALPTHNLDFGYTRLDANLSYSVFHNLMLFTDLTNLLNDQHIGPIGYPGPPLTIRAGLKLRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H2</accession>
    <name>E8X5H2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2486</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580835.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2486"/>
    <dbReference type="EnsemblBacteria" id="ADW69519">
        <property type="protein sequence ID" value="ADW69519"/>
        <property type="gene ID" value="AciX9_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2486"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="HSNRCHG"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="159"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="487" mass="53633" checksum="0860234E1783C8AE" modified="2011-04-05" version="1">MASEVQRGRLGGSEGQPVLHLLVVEDNASIRAACLEIASNMAFSAVGAPDMKEAEEILRHQAVDVLLLNLKIPGGGGMDLLERVKKLQPDTVVIAMTAAASVSSAVEAMRVGAAEYLTKPFALEELTSVLENAGARRQFDLESRRLRERLRSQRGVGNLIGHSPEMEKLYRILSKVAHTSHPVLIVGERGTGKELVGKTIHSTGLHAQRQFTPVDCESLAPEMIENELFGFVKGAFAGAIRNKAGLLATLEGGTVFLDEISELPLELQGKLVRALQDREVWPMGASHPVPLTARILASTSRNLVAMVEAGRFRRDLYFRLNVVNLRIPALRERQEDIPVLAMHTLSKAQRDQYAEKEFPRTFSDDVLRLFLEYEWPGNVRELEAVVERACAVSSGPVVNLGDLPSPLQEFWMQGRSVRRVDLEAEADQDLGHIVSMAEVEKKTILTAIQMLNGDKLKAAKVLGIGKTTLYRKLKEYGLGEGPERDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K0</accession>
    <name>E8X5K0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ordered locus">AciX9_3624</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581938.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3624"/>
    <dbReference type="EnsemblBacteria" id="ADW70627">
        <property type="protein sequence ID" value="ADW70627"/>
        <property type="gene ID" value="AciX9_3624"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3624"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_3_0"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="535" mass="56378" checksum="F3B093328106DBC7" modified="2011-04-05" version="1">MGKNLATKLAAIVVVLLFFIYGIIGIPHGSLKQSIADRIHLGLDLKGGIHLVLAVHVEEAVASTTDRDVQRLEAALPAGGVTGATVGKSDPAHQDIITITGVPVGQMSSLRTLVGGNDYASYEASSQPDGSMRLTMKPTAISDLEARTLETSIETIRQRVDSLGVSEPTIQKYGLGDNQVLVELPGIANADEVEQAIQSTSKLAVYAVVSGPYESEQAAMTTLNNVIPPDATLVHGQSTPNSPDQVWLLNRASEVEGTDFRDASGGTDVNGRPNIHFTLTTEAGDRFYKYTDAHKTGSPTPGSMAIVLGNKVREVASINGAIRDQGEITGTFTQAEVDNLSLMLRTGALPASISYLETRTVGPSLGAASIRQGVIAAVVGMAAVMIFMLIYYKGSGINADLALLLNLLILLGFMGYSHATLTLPGIAGVILTIGMGVDSNVLIFERIREELRAGKTAAAAVKEGFAHAWITIVDTHVTTIVSAAILFLFGTGPVKGFAVTLTFGLLANLFTAVYVSRLIFDAHLKGKERGTALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U1</accession>
    <name>E8X5U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4029</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572737.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70825">
        <property type="protein sequence ID" value="ADW70825"/>
        <property type="gene ID" value="AciX9_4029"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4029"/>
    <dbReference type="HOGENOM" id="CLU_023194_24_0_0"/>
    <dbReference type="OMA" id="TWDYNWH"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="48776" checksum="4C7E4C93A873EAF6" modified="2011-04-05" version="1">MITRREFLEKATTSTAALAVASTAKSYAQIMGSNDRLNFAVIGLNSRAYAHLSALKANKAKARITHVCDVDSVTLKKFAGATEQMMGTAPATDKDFRHILALKEIDAITIATPDHWHAPMAIAGLQAGKHVYVEKPCSHNPAEGALLVQAQQKYGKLVQMGTQQRSSPHTIEIVDKIHNGLIGHAYFAKAWYSNVRKSIGTGKEVPVPAQLDWDLWQGPAPRQPYKDNLQPYNWHWFRTYGTGETLNNGTHEVDVCRWALGVDFPERITSSGGRYHFKDDWQFYDTLVTSFTYPDKMISWEGKCCEGMKYYNRDRGSVIMGTTGSVLVDRDGYEIYDLKGNKTSEFKVGQKTSSADLVGADSMTDAHFANFIAGVQKGEKLNAPIAVGNVAVTMLQLSNVAWEMNRELKLDPANAHIQADSEAMKLWGRDYEKGWAPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X6</accession>
    <name>E8X5X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4077</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572772.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70860">
        <property type="protein sequence ID" value="ADW70860"/>
        <property type="gene ID" value="AciX9_4077"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4077"/>
    <dbReference type="HOGENOM" id="CLU_008973_0_0_0"/>
    <dbReference type="OMA" id="WGRDFSD"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="34648" checksum="7039068B300083BB" modified="2011-04-05" version="1">MLYKISHRTTYKYVSPVSFGNHVACLKPRSYDRNQLIENVRLISPKPLTFTERTDFFGNVLWFFTVQEPHEELVVESLSQVLRSPGQPEGAPASLPWEQSTRSLAEDHTPAGLDAFQYQFESPRIRTNPEFAAYALESFTPGRPLAEALLDLTRRIHRDFRFDSKVTTVRTTPEEVFKKRGGVCQDFAHLQIACLRSIGVAARYISGYLRTYPPPGRPRLIGADASHAWLSAYDRAAGWLDMDPTNDVAPTDGHVTVAWGRDYGDVSPLRGLILGGGGHTLRVEVDMEPIEDAASSSGKPFASPEEASARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X634</accession>
    <name>E8X634_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface presentation of antigens (SPOA) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4138</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572830.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70918">
        <property type="protein sequence ID" value="ADW70918"/>
        <property type="gene ID" value="AciX9_4138"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4138"/>
    <dbReference type="HOGENOM" id="CLU_2301871_0_0_0"/>
    <dbReference type="OrthoDB" id="2066469at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FliMN_C" evidence="2">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="10572" checksum="0121EBC384EB3181" modified="2011-04-05" version="1">MGTASPVSTTQQAAPQATIAVFKDPDPGKLVPWLPCTLALEVSVVGFTVGSLLKLTKGSLVQTSCHQSTDIPLHVNGILMAWTEFEVVGERLAARITDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X639</accession>
    <name>E8X639_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_4143</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
            <plasmid evidence="12">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70923">
        <property type="protein sequence ID" value="ADW70923"/>
        <property type="gene ID" value="AciX9_4143"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4143"/>
    <dbReference type="HOGENOM" id="CLU_1784140_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="17529" checksum="CED27BE62644BCA5" modified="2011-04-05" version="1">MAYRFSLATLLRLREIAEEREERALGQILQQIVQAKQRIETLRRHRIHLLALREADLQRQMAAAELHVSYGQIHSLERMQQQAREQLIKLEDLRLKQMKVYEEAHRNKELLAGMREDHLDLYRREQTRQEQNIMDDNFASRRAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X681</accession>
    <name>E8X681_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cl-channel voltage-gated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4186</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572877.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70965">
        <property type="protein sequence ID" value="ADW70965"/>
        <property type="gene ID" value="AciX9_4186"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4186"/>
    <dbReference type="HOGENOM" id="CLU_015263_5_1_0"/>
    <dbReference type="OMA" id="PMISGSG"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="574" mass="61772" checksum="4D7A98D8CD4CAB14" modified="2011-04-05" version="1">MPTISEDQPLPQREERLFLLLSIFIGIISGLLVVSFRMAIEWLSVLLQGSAPAPHQTRLLVAPCLAGIAIALLTRYVFPQVKGSGVNQTKAALYIHNGYISIRTMIGKFLLAALAIGSGHSLGPEDPSLQIGAGVASLISRRVGLSRERLRLFAPVGAAAGLAAAFNAPISAILFVIEEVIGQWTSAVLGSIVLSAVAAVVVARWFWGASPMFRIPAISLRDPRELLAYAVLGIVGGVASLVFAKALGWLRPALRKQPQWFQMMQPALAGLLVGSIGYFGLPEVMGAGYGAIDQAMHAQFAFKMLLLLAAFKIIATTLSFSSGTPGGMFAPTLFTGAMLGAAVGSFEHHFFPSLTGSIGSYALVGMGVLFAAFLRVPLTSVFMVLEVSGNYSIILPVILANTIAYLISRALQPVPIFELFTHQDGLYLPSMEEQREESELHFEDALQPVSVPILQGADTVANTRIALNGRTTSPEATIFLIQCSDATWYAAYNAELTTLFAHLDAEEDSIDPSLPLQQALGPERTPLIFPDQQLASALPHFRRWPLLPVSNRAMRGALEGVLTLDDVLKRYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A3</accession>
    <name>E8X6A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4209</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572899.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70987">
        <property type="protein sequence ID" value="ADW70987"/>
        <property type="gene ID" value="AciX9_4209"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4209"/>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="YYHEEAH"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="49004" checksum="330BADDA4D851887" modified="2011-04-05" version="1">MRSVLDETAQWIPMSTAEQDKVREQMNRLLETNHFKNSRRYPALFRFIVEETLEGRGEYLKERLLGIRVFDRPANYDTATDPIVRVTIAEIRKRIAQYYHDEAHDAEMRIELLPGHYAPEFRFRKEADYERQAAMPPLETRHVSAPRANVRQTTEAGAEIPAKPVPLAAKKGLGSRTWLAISSVALILVCAASTLLWRAAHPSALEQFWGPVLAGHKPVLLCIPTGAGKTGGMAAFTSADLHSRPGVPVIPGGPTFLDHESLEENVVFSDVLAMVKVGGLLAVREQEYRPRLNTSTSLDDLREGSAVLIGGMDNQWTLEAIAPLRYRFAGSDATSYWILDTTNPTQKDWSLDLKTKLVNVRRDYAIVARLHSDQTGQMEVVVAGIGMAGTAAAGEFVVDPQQMEGLRQKIGKDFATHDFEAVLGTDVINGIAGSPKVVAVWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D5</accession>
    <name>E8X6D5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4243</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572931.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71019">
        <property type="protein sequence ID" value="ADW71019"/>
        <property type="gene ID" value="AciX9_4243"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4243"/>
    <dbReference type="HOGENOM" id="CLU_013148_2_0_0"/>
    <dbReference type="OMA" id="TVESMCI"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="985" mass="108474" checksum="C433664FCF67F88F" modified="2011-04-05" version="1">MSRRTHHITSPRNSDQTQNVPQDDPSGQHRVDRRKFLGGMAGSALLTAVQRSTAFAQASELQANLARVAMPSSLYSTSENKVSALNDGFVPATSHDRTNGGYVLRPRLEDAQWVQYDWSRPVATSKVDLYWGVDRTSKNPEYSRANIALPASYRVLYWDGTDFVPVTNPKGLGTSLDAFNTTTFDEVRTSKVRIEVKPDGMHPASILEWRVYSSGPIPTLPPVVDAGLDRSVVLGGKTYLSGKATWLDPKPQDVVRWGKESGPGTVSFANPAAAVTTATFSASGDYVLKLSANGLEDQPPSTIRVHAEPSPPKKRLDVVYTRKYSIDSPLWNVRAKALIVNWIPHCIDYCERSDLREGQGGLDNFLEAAKALRGEPHAKHIGYVFSNAWVHQTVESMCIALMVDPQDDPEIIAAQARMHTTIEKWIPIILAAQEPDGYLQTAYTLADRTVWPAHWTPAQRGNHEGYVSGYFIESAINHYTLTDGQDLRLYNAAKKLADCWAANIGPGKKEWFDGHQEMEQALVRFGRFVNDQEGNHRGDSYIQLAKFLLDSRRGGQEYDQSHLPPGQQYEAVGHAVRATYFYSGMADIAAETGDTDYQSAVISLWDNMVNRKFYLTGGIGSGETSEGFGPNYSLGNQSYCESCSSCGLVFFQYKLNIAYHDARYADLYEQTMYNALLGGVDLEGKSFCYTNPLVNSQRTLWHVCPCCVGNIPRTLLMIPTWAYVKGAGGIYVNMFVGSKIHVGEVAGTRVEMVQKTNYPWEGAVRITVNPDQAKTFSVYVRIPNRNTSKLYTETPAISGVKRFAVNGKPVQPLIEKGYAVVTREWKAGDHIELELPMEPQRIVADSRVKADTGTLALKYGPLVYNVETADQPNINQPLSSAPLKAVWRPDLLGGVMTITGTWQDGSPMLAIPNFARMNRVGPPREFLGDPAVNYAPGSTTSAGPAPSNTNSNPGVVNNNAGSVAPTTNTPVGRRGPRKIDSKVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J7</accession>
    <name>E8X6J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582168.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71147">
        <property type="protein sequence ID" value="ADW71147"/>
        <property type="gene ID" value="AciX9_3864"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3864"/>
    <dbReference type="HOGENOM" id="CLU_025996_2_0_0"/>
    <dbReference type="OMA" id="LVNFRRH"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="337" mass="38191" checksum="06B93B3FD828EB57" modified="2011-04-05" version="1">MSQPQNCLAISVAMCTYNGMRYLPEQLKSFSEQQRLPDELVICDDASSDGTPDLLQEFARTAAFPVHVHENSQNMGYSRNFMQAVEFCTGDVIALSDQDDLWYPHKLERIEELFVEHSEAGGIFSNGDLVDSLSARLPGDLWGSFSFDSGSQRHVANDDAVKVLLRRNVVTGMAFAFRSSYRQVVRRMPPHWPHDFWLALMIAAESRLLPCPEHLVAYRVHTNQQIGVPINGAEKRGLLRGKGLGHYRARSRERNLREYTRDAVQFESLIEASKSDSHLAEAVWLPQAAAKARHMRRVVHQLESGRAARWVSALTHWNSYRLYAPTGLKALARDLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L7</accession>
    <name>E8X6L7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3844</name>
        <name evidence="3" type="ordered locus">AciX9_3887</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71130">
        <property type="protein sequence ID" value="ADW71130"/>
        <property type="gene ID" value="AciX9_3844"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71167">
        <property type="protein sequence ID" value="ADW71167"/>
        <property type="gene ID" value="AciX9_3887"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3844"/>
    <dbReference type="KEGG" id="acm:AciX9_3887"/>
    <dbReference type="HOGENOM" id="CLU_027402_34_1_0"/>
    <dbReference type="OMA" id="RCANADL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10454" checksum="FD9D171091BD8C4D" modified="2011-04-05" version="1">MGRGKKYQPEQVVNLLRQIEVAVANGKTTALACKEAGIVEQTYFRWRKEYGGLQVDQAKRLKGLEQENSKLKRLVANLSLDNLALKNFASGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P0</accession>
    <name>E8X6P0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3914</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582208.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71190">
        <property type="protein sequence ID" value="ADW71190"/>
        <property type="gene ID" value="AciX9_3914"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3914"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="GIDREVH"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1034" mass="109654" checksum="FBAC7BBD49FFC3CB" modified="2011-04-05" version="1">MTNSPAPKESFWLTTAAKPIFFFLAVLTLAGVYAAFQVPISVFPDTNFPRVVIGVDNGVMPVEQMQVTITKPIEDAVNSVPGLQTVRSTTSRGSAEVSLFFDWNVDMFQTLQLTDAALSKIQSELPATAKITTNRLTFATFPIVAYALTADDRGPDTISRTALWQIATYQLKPPLNRVLGVSTVVVQGGQVPEFHIVPDPARLQAAGVTVLDIVNAVQASNIIDSPGLYEADHQLILGLVGAQAHDAETLGHLIVKTSASGNPIRISDIATLGPATLPVYTRVAADSHPAVLLNITRQPSSNTVAVATAVAAQVAALSKTLPPGVHLTPFYDQSELVHESIASVRDAILIGLVLACVILFLFLRDWSSSLVAGLVIPVTVAITILFLWIIGQSFNLMTLGGLAAAIGLVIDDAIVVVENIVVHRDSGQSRTEAVRLALREITIPLIGSTITPVVVFLPLIGVTGVTGSFFRALAVTMTVALLTSLMLALSFTPALSLSLLRQAEPGTGAKPHAEEHGPFMRRVLALHGTALNWTIQRSWALILIAAVLLVSGYLAYGHLGSNLLPAMEEGAFVVDYIMPAGSSLAATTAVLDQVDHILHADPDVLITTRRTGLQLGLAAVTEANTGDISVRLKPGHTRGFDEITADLRAKIKEQAPQLDVEFVQVLEDMIGDLSNSPEPIQIKLFSTDTALLHDLAPKVQAAIAAIPGVVDTQNGIDNTLSGPATNFQVDPSVAARLGFTPQEIAEDATSLLDGLPTNEPMIIAGRPYTIRVRMADEHRASLDAIQNTVFNSSTGHTATLGSMAQITELPPQNEIRRENLVQVDLVSGRLEGSDLGGAMVKVKAAVAALNLPATVRVEFGGTYQEQQKSFSDLARVLLLALALVFGVLLAEFRNLSAPFAILTSSVLSIAGVLLALLITHTDFNVASFMGLIMVIGIVAKNGILLLDADERARAEGASARDAMVHAAQRRLRPIVMTAVAAMCGMLPLALALGSGSQMLQPLAIAVIGGLLLSVLLSLIVTPALYYQLTRHHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q7</accession>
    <name>E8X6Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3931</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582225.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71207">
        <property type="protein sequence ID" value="ADW71207"/>
        <property type="gene ID" value="AciX9_3931"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3931"/>
    <dbReference type="HOGENOM" id="CLU_2167402_0_0_0"/>
    <dbReference type="OrthoDB" id="2218666at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="11622" checksum="C94F4DB2478B67EA" modified="2011-04-05" version="1">MPTPLLTKYFQTFTLNAVGEISIAGILNVAAYSKINLELLGTPIAGHVMQVEVFMGVLSGQTVGGTVLQFPLTTTGIIHSFNVVGPEMSIVITGGPPNTSLAIQAWTFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W3</accession>
    <name>E8X6W3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3989</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="acism-e8x6w3">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71263">
        <property type="protein sequence ID" value="ADW71263"/>
        <property type="gene ID" value="AciX9_3989"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3989"/>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_0"/>
    <dbReference type="OMA" id="EMRYICP"/>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="55192" checksum="B2DE497C59BD39F8" modified="2011-04-05" version="1">MMEHGLLSRRRLLTHGACAAVGLWGRRAFALGAECSAVVKTGLGTLVGECGQGVRVFRGVPFAAPPVGDLRFRAPAKALAWTGERDATRFGASAPQPREQGVTHSEDCLYLNLWAPQGKGPFPVYVWIHGGGFTGGHAFEPVYDGTMLAQQGVICITVGYRLGVLGFLDVEPMLGREYAGSANNGLRDLMAALSWVQAHVADFGGDPGRVTVGGESAGAKLTDILMGIPAARPLFSQMISESGGAERVWPHAVAQSIGSGFAEKWRASSGLTDRDLLTASSDLLLVAQEKMIAEWPQHFPLRPEIDGTLVPRLPIQAIDAGSCKGKRLLIGTNRDESALFVGPHPGHDASAAELGNMPQKEFVGIYAQYKRLYPEMTDDQLRIRALTAEEYWIPSVRVADAHVKAGGKAWMYRLDFAEARGRLANFAYHSLDVGLVWDKPHPGIGNDADESALAVTMQSAWASFIRGGAPVAAGLPEWPEYETGNRKTMILDVHSGVVDHPQKAELALWDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X714</accession>
    <name>E8X714_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3837</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582145.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71123">
        <property type="protein sequence ID" value="ADW71123"/>
        <property type="gene ID" value="AciX9_3837"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3837"/>
    <dbReference type="HOGENOM" id="CLU_016031_8_3_0"/>
    <dbReference type="OMA" id="WRKRTLP"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230307" evidence="5">
        <location>
            <begin position="33"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="6">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="467" mass="50200" checksum="E7710D56339DB8C3" modified="2011-04-05" version="1">MTERMNASPRRTFLKTMLQAGAAATFTSPVFALEKKAHTTPVTAAPSVQLNVRDFGAIGDGITLETESLQRTIDRCGVLGGGEVIIPAGRYLTGSVSLRTKVTLRLAAECVILGSPDLAHYAVSQVRWEGKWIPGYLGLIHALDARKIAVLGPGSIEGNVAVAGRPTKENPLRRPALIEFLYCDDVHLEGFSTSYAHMWSIHPTCCDNLVFRNLTVRSTLTNGDGIDIDSCRHVLIDTCDIASGDDCISLKSGRGEEAYQLARPTEDVRIVNCTLEGRGFACIGIGSETSAGIRRVLIEGCRVTSVYKFAVYIKSRVGRGAFIEDLTVRDMSAAKMRMGFLKISQTSAGVQDENPVPGLDGLPLFRNISFLRIHVDDAPVLVEAKEISADKLLDGLTLDGFTGTCAKGLELANITHATLRGIAVSGFTGPLLRIDNVTGKGLQGAEKLPPRGRTELVATPAVPYKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X789</accession>
    <name>E8X789_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4371</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71323">
        <property type="protein sequence ID" value="ADW71323"/>
        <property type="gene ID" value="AciX9_4371"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4371"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_3_0"/>
    <dbReference type="OMA" id="EQIRFAY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="8">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="25218" checksum="7A9448C348586B27" modified="2011-04-05" version="1">MPKVIKSKATPKTSRHPKGQRVGYVRVSTLDQNEHRQLEGIELDKTFLDKASGKDVKRPQLTAMLDFVREGDSVFCHSMDRLGRNLGDLRKLVDLMTERGISVHFLKEGLTFTGEDAPMANLMLSVMGAVAQFERDLIRERQREGIDLAKRAGAYKGRKRKFSPERAAELSRRLAEGEEKASLAREFGVNRATIYRYVGWAAMEVAALAKKPGTAKRVRTSSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J9</accession>
    <name>E8X7J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4488</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4488"/>
    <dbReference type="EnsemblBacteria" id="ADW71433">
        <property type="protein sequence ID" value="ADW71433"/>
        <property type="gene ID" value="AciX9_4488"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4488"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041517_0_2_0"/>
    <dbReference type="OMA" id="QPYPAQF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="123"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="476" mass="53834" checksum="B5B5244098C1C132" modified="2011-04-05" version="1">MSKQELRRVEVLTEVLAGRRTTESAAGVLGVSLRQAQRLAVRYRNGGGGALIHRSRGRPASNKLGAGVRELVLELIRQNYRDFGPTFAAEMLQERHGIEVSRETLRKWMVGAGVWLSRKQRRSFHQPRLRRESLGELVQIDGSEHRWFEQRGEPCTLLVFIDDATSRLMQMRFVPSESTASYFEALDGYLKSYGYPVAFYSYKHSVFRVNKPEAKGGAGMTQFGRALAELNIEIICAKSSHAKGRVERANRTLQDRLVKELRLDNVCDLEAGNASSRRSSLASATDSLSLPQPLPICTRRLNLPANRMTDILCHREQRHVGDQLTLAYDRKQFILERNEVSEELGGRYVDLYHFSDGHLEVRSNGHVLPYRVFDKDQRVSPAAVVENKRLGHALSLIKARQDAKQLTKFQTNSEKNGYRKKGRTIAGAPSATRAAMEMWKSPKNGDSTHPHSTTAISYNDKTALQIQRRYRFAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P3</accession>
    <name>E8X7P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4540</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4540"/>
    <dbReference type="EnsemblBacteria" id="ADW71477">
        <property type="protein sequence ID" value="ADW71477"/>
        <property type="gene ID" value="AciX9_4540"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4540"/>
    <dbReference type="HOGENOM" id="CLU_2569062_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="8926" checksum="A0ADC0C5AE896E50" modified="2011-04-05" version="1">MPTDEIEVDANGEILVSSITGYSVAKTLAGQVFFRVQYLNPDLRTMSATQLILEPKDAAELGRMLQLYAEPFVQSPHGTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R5</accession>
    <name>E8X7R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4568</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573218.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4568"/>
    <dbReference type="EnsemblBacteria" id="ADW71499">
        <property type="protein sequence ID" value="ADW71499"/>
        <property type="gene ID" value="AciX9_4568"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4568"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717215_0_0_0"/>
    <dbReference type="OMA" id="MRCESAK"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="385" mass="43124" checksum="4FF80C95668BBB61" modified="2011-04-05" version="1">MSPDHIDVLIPAYNAAKTITHSILSLQNQTFKDFSVHIVDDGSTDGTGELVKALMIDDPRIRLYSQANNGIVDALNNGLGYCRARYVARLDADDIAQPDRLATQLRFLNDNPDFVAVGSNTRHIDEAGLPTGSYSRLSMPIKGNPYSLPAKEPYIIHPTWLVRRSAVDRIGGYRHVPLAEDSDLLWRLSEIGQLHNLTEILTDYRVHENSLSSSSVVNGRVMAIGSQLAAFSARRRREHKNDIVFNSTTVNSLKIVPTLKAMTKSTEVVLGQDELVDFRACVAAKLLELSSYRPYELDEGDCRYIRDALAAMKQYRPTISQSEVRAHAISAAARLCRAGRWREGRLLLRPDDTMSFVIRLLGRMPVLSTARAFVLRKRRAHEMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S0</accession>
    <name>E8X7S0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4574</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573223.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4574"/>
    <dbReference type="EnsemblBacteria" id="ADW71504">
        <property type="protein sequence ID" value="ADW71504"/>
        <property type="gene ID" value="AciX9_4574"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4574"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050201_0_0_0"/>
    <dbReference type="OMA" id="VAITFRA"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="329"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="440" mass="47811" checksum="D7F7E88B84D85290" modified="2011-04-05" version="1">MVSQGNGTNAIANTLVSRILQQGLNAATGIVTARALMPSGRGQLAAMILWSLFLAGLTTFGLPTALIYFICRHPEFKEDLISSGLAMSVCAGVITMVVGTYFLPSWLHQYPSWVVINAQWFLIFTPICSITLAGRSVLEANGLFGKSNAQQLMVPALTLVGLLSALAFHHLTVSIAALAYTLPTIPVFFFMLKQLRPLLPKYLHFPRLWACRMLLSYGIRSWGIDLLGTLGSQVDQVLVIRLLTPADMGLYAVTLSLSRIMSVIQSSAVTVLFPKATGLSTEEVIGLTGRATRISAGLTLMGSLVVAFVGPWLLKIFYGRKYIHSVGAFRVLLLEVTISGCAFLLSQAFMALGRPGLGTVLQAIGLALSIPLMLWLIPMWGVLGAATALTISTVARTILVYFSFRMFLKIRPPDIIPKREDFILLKDQMSLRFKGRSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T6</accession>
    <name>E8X7T6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4590</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71520">
        <property type="protein sequence ID" value="ADW71520"/>
        <property type="gene ID" value="AciX9_4590"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4590"/>
    <dbReference type="eggNOG" id="ENOG502ZVMN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052211_0_0_0"/>
    <dbReference type="OMA" id="RIAIHED"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043733">
        <property type="entry name" value="DUF5677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18928">
        <property type="entry name" value="DUF5677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="267" mass="30077" checksum="8823470B9DFD47F9" modified="2011-04-05" version="1">MTEGRGVVVDQDIAKRARAHLIRLELFRELLARMYRESIVQYEFSVRLALLFGSVLKVRQAGLSVKVLAEQMCVEEIVTIGRTIVEVVVNAAYLQYAEDIEIDRYLQFDKEFISRQNEFLQLQSGTRPVPGIVQKLKANALRVSMKIMPKDDDPRWSTQSIAQRAAFADKVSESPIMALLVKTLHARGHSASHGTFQSMTPFISALETMVVAETDDRFDELAEALFGVNLSLMTLCLYLNNFLNLDLDEAIHHAARASADDRGSHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA7</accession>
    <name>E8WVA7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0208</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578610.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0208"/>
    <dbReference type="EnsemblBacteria" id="ADW67282">
        <property type="protein sequence ID" value="ADW67282"/>
        <property type="gene ID" value="AciX9_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0208"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_0"/>
    <dbReference type="OMA" id="INVRYTK"/>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="43651" checksum="A0731C77BE80525C" modified="2011-04-05" version="1">MSEQRKNAAAAVESNKLKHAGTASLILASAGFLAGCTPKPPAAPPPQPMPVTVVTLEPTDVPISGEWVGTLDGYVNATIQPQANGYLIKQDYREGTQVSKGQVLFEIDPRPFQAALDQAKGQLEQAKGQVAQAQAQLGLAQINVNRDTPLAQARAIAQSTLDNDTQQKAQQEAAVKSAQANVSAAEATVENAKLNLGFTQVRSLISGVAGQATLQVGNLVNTQSVLTSVSQLNPIKAYFSISDSEYLALVQRTKAGGGDLLKNASAVPLTLTLSNGEAYAQKGHIAYVDRQINAQTGAIRIAASFPNPGNVLRPGQFGRIKADTQVRHNTLLIPQVAIQELQGLQQAYIAGPDNKAHLVTLKLGPQVGTNWVVEDGVSPGARVITDNLLKLGEGSPVAPHDGPPAAPTSQATSSAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG6</accession>
    <name>E8WVG6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannan endo-1,4-beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1354</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579737.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1354"/>
    <dbReference type="EnsemblBacteria" id="ADW68414">
        <property type="protein sequence ID" value="ADW68414"/>
        <property type="gene ID" value="AciX9_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1354"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018488_2_1_0"/>
    <dbReference type="OMA" id="GTAPNGY"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="37456" checksum="94BFAA48402EFF78" modified="2011-04-05" version="1">MAEENVSTKAAALKATLNVKGRFLYDRQGNKVVLRGVDYQALDQWKYPGIDYLDEVLQTGANAIRIPWYKVYPTKGRGAFTIGNLTNLIDRCVAAKVIPIVEFADFTSNAKMSLLSTVVTPWWTSTGDQTQNGVFAALKARESCLILNLANELGDYRWAEGETPAAALSTYKTDYEKAIKAMRTAGYTCPLMIDAPDSGTSSEAFTTSGTGAALVASDPLKNVLLSAHAYWAGFDGRPGVQAAIAADLPIVIGEVANKEGDPPGNLPIYDLDGTNENTPTTTGFTYQSFLTTLLADQVGWLAWSWFPDDVDARNMSSDGSFAGLTTYGTDIVNNPTYGLKATAVRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH0</accession>
    <name>E8WVH0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1358</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579741.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1358"/>
    <dbReference type="EnsemblBacteria" id="ADW68418">
        <property type="protein sequence ID" value="ADW68418"/>
        <property type="gene ID" value="AciX9_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1358"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_0"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="48477" checksum="3936B026AE62F37A" modified="2011-04-05" version="1">MIARYTRPEMGRIWTDENKYRCWLRVETAASQALARAGIVPQEAADAIRDKGNFSVDRINEIEAEVRHDVIAFTTSVSEFVGPESRWFHYGLTSTDVVDTAQSLQLKEASAIIREGIVKLAEVLKRRALEFKMTPSIGRTHGVHAEPTTFGLKLLLWYSEVQRNLVRFDAAAEDLRVGKLSGAVGTFGHLKPEHEEAICEALGLKPVAIATQIVQRDRHAAYIATLAVLASTLDKIATEVRHLQRTEVREAEEFFSEKQKGSSAMPHKRNPIVSEQISGLARVIRSNAQTAFENVALWHERDISHSSAERVIFPDSTILADYLLAKTTNLIDKLLVYPARMLKNLESTGGLIFSGQLLLDLAESGMLREDAYRLVQGHAMRSWKEDLVFRDEVAKEPEITSRLSPEKLARAFDYNRQLANVDAIFTRVLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK9</accession>
    <name>E8WVK9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2506</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69538">
        <property type="protein sequence ID" value="ADW69538"/>
        <property type="gene ID" value="AciX9_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2506"/>
    <dbReference type="HOGENOM" id="CLU_1501469_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="20379" checksum="B8DCBBBAFBC37FB3" modified="2011-04-05" version="1">MRSATSDEARRYCNQDGGPRKVASDGCSVFFDVPEEHSFFLKSPTDYRTLAFLCQRLVNGVYGGNFPGGLVWLHMWNVGADYLMPLGWRIVEDMRRANGDQRPLDVAPAQIFREDETLDVQLFLMTAFGNGWPGCFVPAIGDFIVEFRSSHRLFFYCEKEATVKRLCMELKAFEPQVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL5</accession>
    <name>E8WVL5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580859.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2512"/>
    <dbReference type="EnsemblBacteria" id="ADW69544">
        <property type="protein sequence ID" value="ADW69544"/>
        <property type="gene ID" value="AciX9_2512"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2512"/>
    <dbReference type="eggNOG" id="COG3254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_4_0_0"/>
    <dbReference type="OMA" id="MIMDVED"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="13641" checksum="DA60C6246AFA717B" modified="2011-04-05" version="1">MKRFCLALDLRPDPLLQEQYVRYHQHVWPEVQQSLRDAGVQDMEIYKLGDRLFMIMDVSDDFTFERKARMDAGNPKVQEWEAMMGRFQNVSADDDPYSRWQSMDRVFQLDSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS7</accession>
    <name>E8WVS7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iscS</name>
        <name evidence="10" type="ordered locus">AciX9_3685</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3685"/>
    <dbReference type="EnsemblBacteria" id="ADW70686">
        <property type="protein sequence ID" value="ADW70686"/>
        <property type="gene ID" value="AciX9_3685"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3685"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_0"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="37"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="436" mass="47754" checksum="C75000D32931D8BC" modified="2011-04-05" version="1">MTEETAVLNEQTASMTPNGMVITESNEPLPEGVTLPIYMDNHATTPMDPRVLDAMLPYFGKIFGNAASRNHQFGWEAEQAVDKSREQISKLIGCTPKEIIFTSGATESNNLAIKGIAEMYKERGNHIITQTTEHKAVLDTCKKLERQGYDVTYLQVQADGLISMDDLKAAITEKTILVTIMFANNEIGVIQPVEEIGKLCHEKGIIFHTDAVQAVGKVPVNVQSMNIDVLSLTAHKIYGPKGVGALYVRRRNPRVQITEQINGGGHERGMRSGTLNVPGIVGLGAACEIAMNEMEAEGKREAELRDYLKNKFEAALDYVTVNGNMDHHLPGNLNMSFVHVEGESLLMGINDIAVSSGSACTSATLEPSYVLKALGLGDDVAHSSIRFGLGRFNNKAEVDYVSDKIINVVNHLREMSPLYEMVKEGIDLSKIEWAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT9</accession>
    <name>E8WVT9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein UCP028291</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3697</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582007.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3697"/>
    <dbReference type="EnsemblBacteria" id="ADW70698">
        <property type="protein sequence ID" value="ADW70698"/>
        <property type="gene ID" value="AciX9_3697"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3697"/>
    <dbReference type="eggNOG" id="COG3553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127482_1_1_0"/>
    <dbReference type="OrthoDB" id="1858344at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014543">
        <property type="entry name" value="UCP028291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09981">
        <property type="entry name" value="DUF2218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10956" checksum="806E4C8BA96A265A" modified="2011-04-05" version="1">MMLSRAELRTTHAVEYLRELCRHWAHRFPVEYDDTHGKIKLDRAICTLMSAPAALSVYLEVEDAADQDDAEKLIADRLRHIGSQETLDFHWFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW01</accession>
    <name>E8WW01_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0233</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67307">
        <property type="protein sequence ID" value="ADW67307"/>
        <property type="gene ID" value="AciX9_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0233"/>
    <dbReference type="eggNOG" id="ENOG502ZTVW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007471_0_0_0"/>
    <dbReference type="OMA" id="RAVWIPQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230357" evidence="2">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="27205" checksum="E74C29DB13DE8C2A" modified="2011-04-05" version="1">MTARMAERIVAMMGLSLAMGVGGAQGVPAAQTPGAPVQTPTGPSTSMTPPVVSPSNGRTNTLTHGTSPVAGVAGPGGVSGAPVQTPELATPDVKADGDKGSVGEIPIDTPGATDPKDVSAVGSPVPAPPRAVWIPQGAGLSLRLNRAVSSDSDKNGAMVDGVLLAPVKLSNGTMLAKGTPVRATVLAVAAAGQIASAGALSLQVVRVGNVAVTTNVVEFDGQRGKTEVADANPEKGTEAMVQAGASLQFKVLGAGDAWDSDRRTGNGKIAGRAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW82</accession>
    <name>E8WW82_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1407</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579787.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1407"/>
    <dbReference type="EnsemblBacteria" id="ADW68465">
        <property type="protein sequence ID" value="ADW68465"/>
        <property type="gene ID" value="AciX9_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1407"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118511_0_0_0"/>
    <dbReference type="OMA" id="HRNTDET"/>
    <dbReference type="OrthoDB" id="1876700at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229986" evidence="1">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="18979" checksum="B481439AED987B06" modified="2011-04-05" version="1">MRNKLAGAVLGLTLGVFAGASAQTAAPAAETHIHKPSAPSTSLTLTVDGKTVKLTPDELAAMPQRTITAHNGHSKVDEVYMGVAVSDLLAKQGVTMAGDGAKKVYRSYLRATGTDKYWVLFAASEVEGEMHQGDVIIALTVDGKPLTEDGKFKLVSTEDKRPARWVRNLESLVFVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB8</accession>
    <name>E8WWB8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1448</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579822.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1448"/>
    <dbReference type="EnsemblBacteria" id="ADW68501">
        <property type="protein sequence ID" value="ADW68501"/>
        <property type="gene ID" value="AciX9_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1448"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_5_2_0"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19886" checksum="4E32277083939E67" modified="2011-04-05" version="1">MKDLIQWEAVKWPDDMAPSRCPIHFTNERQVAASSKTIWSLLTDPYAWPHFYPGVEQAPSLQGSNSLSLGVRFETKLAGQQVLASVQEFEPLTRIAWYGGPIDSEESKAYHAWIITPTPSGCHLRTEETMRGPLWIELAKKAPDAFWLTHEKLLASLANIAEERTNHRNEEETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE1</accession>
    <name>E8WWE1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2579</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580920.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2579"/>
    <dbReference type="EnsemblBacteria" id="ADW69605">
        <property type="protein sequence ID" value="ADW69605"/>
        <property type="gene ID" value="AciX9_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2579"/>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066201_0_0_0"/>
    <dbReference type="OMA" id="ERYARHW"/>
    <dbReference type="OrthoDB" id="798280at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="38641" checksum="2D807485C5135EFE" modified="2011-04-05" version="1">MSENFLQLSEKDKVAVLRTATSSSGRSGPLLEKDVWVVWALSTLFESPLGNHLVFKGGTALSKAYKAIRRFSEDVDLTYDIRALAPELVAKAPQGFDAIPPTRSQEKKWSDEIRKELLPAWLRDHAHPIVEAAMAGLSGVRSRVTDGCIFIDYEPLIAPSRYALPSVMLEFGARSTGEPSSVRPVQCDMQDFIQDVSFPLANPRVMEIERIFWEKATAAHVYCVQGEAGLSQRFSRHFHDLTRLHQEGYLPSAIAAREVAEAVAVHKNAFFAEKDANGNRIDYLEVVRGGITLVPTGNAYDALRVDYRRMVQEGLFVEEPESFEQTMTNCALIQEELNLSPRDPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE3</accession>
    <name>E8WWE3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2582</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580922.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69607">
        <property type="protein sequence ID" value="ADW69607"/>
        <property type="gene ID" value="AciX9_2582"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2582"/>
    <dbReference type="HOGENOM" id="CLU_1728798_0_0_0"/>
    <dbReference type="OrthoDB" id="2163720at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="16164" checksum="5012D0230C817F29" modified="2011-04-05" version="1">MTAMANIQITAKGHDHVHGIGQPILPNIVIQGDQINTHGPVGAVGRNSIGTINYQQQWAGVLNQVSLSQVAIELESLRTELVKTAKVPADFQQLGLIAEAEQHAEKQDGTKVMEVLSKAGRSLLDFAKALVSSQWRAGMFASGAPNSWMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF5</accession>
    <name>E8WWF5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="6">3-dehydroquinase</shortName>
                <ecNumber evidence="6">4.2.1.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">Type I DHQase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="6">Type I dehydroquinase</fullName>
                <shortName evidence="6">DHQ1</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Shikimate dehydrogenase (NADP(+))</fullName>
                <shortName evidence="7">SDH</shortName>
                <ecNumber evidence="7">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroE</name>
        <name evidence="6" type="synonym">aroD</name>
        <name evidence="12" type="ordered locus">AciX9_2594</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="function">
        <text evidence="6">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="6"/>
    <dbReference type="EC" id="1.1.1.25" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2594"/>
    <dbReference type="EnsemblBacteria" id="ADW69619">
        <property type="protein sequence ID" value="ADW69619"/>
        <property type="gene ID" value="AciX9_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2594"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019120_1_0_0"/>
    <dbReference type="OMA" id="TTSVGME"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="10">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="9">
        <location>
            <begin position="360"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="11">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="6">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="7">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="371"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="571" mass="60993" checksum="8E4821043E418535" modified="2011-04-05" version="1">MPNSTAQLLRSRIGKVCVAITGATAAEMLERASLAVKETPFLEFRLDYLSKPAAALPEFKQFLAANNAATAIATCRRAENGGRYKGSAASELEILVEAANSGFQIVDLELESAEALKSAGIDKIRATSAGLIVSWHDFEKTPDLDKVYARIAPFEPDFVKIVPTAQCLTDNVKLMRFIERMSDEASIVGVCMGDSGIISRVLGVRAGSTFTFAAATVGEETAPGQILARTLLETYRIAEVDAATKVYGVAGDPVNKSLSPLMMNTAFRRETVNAVYLALQATDVTDLVKLIQEIPIQGVSITMPHKQSIMAHLAHTDPLSAKIGACNTVLRVPPSAGEPAKLYGFNTDVQGILIPLQKRIELKGAKALVLGAGGSARAAVFALRDKGAEVFILNRTLETAAKLAKQSGAKVIKREALLKSTFDVIINATPVGMSGQSVEPILTAAELKTTKLVFDLVYNPVDTPLLKQARSLGLSVITGVEMFVQQGARQFEIWTGKPAPEDEMLKVVIHALRQQYGGMVEPEAAPARVAEVEEVEEAVQPEPEPAAKPKVTTKAAVKKAPAKAAPAKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI1</accession>
    <name>E8WWI1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="11" type="ordered locus">AciX9_2620</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580960.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2620"/>
    <dbReference type="EnsemblBacteria" id="ADW69645">
        <property type="protein sequence ID" value="ADW69645"/>
        <property type="gene ID" value="AciX9_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2620"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_0"/>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="OrthoDB" id="213210at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="583"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="693" mass="74565" checksum="74CF10722A314DDB" modified="2011-04-05" version="1">MADFLFEIGLEEVPARMIAQAEAELLKRTVGLLERERLVAGAVEAKSYSTPRRLAVVVKGVLARQEDVSEEVLGPATKIAFKDGQPGPAAVAFAKKNGVEVSALRVVTNAKGEYVAATSVKAGRSAAAVLAEELPKEIAGIYWAKNMYWRAGRPERFVRPVRWLVALLGDEIVPVSFGGYEAGRVTYGHRVLFGDAAIAVTPASYVEELAKASVMVDVEGRRHVIRKALDKVCRTAEGTRWREDHGLVDKMTHMTEWPSVILGGFEKEYLALPEEVLVTVMRDHQNYFAVESADGKLAPHFLAVLNTVADETGQAVIRHGNERVLRARFNDARFFWEFDQRVPLEERVALLENVTFQKDLGSYAAKSVRVGALALSLAATVPGVDLEALKAAARLAKTDLTTELVKEFTELQGEVGGLYAEAQGVAQAACNAIYDQYRPVSTEDRIPRTVEGQLLAMADKADTIAGMFGLGLEPTGSKDPFALRRAANGIVKILGEGATGLGIGQVVRAAVGDNLVLVRKLEVFFAERLEFYLREAKGQAYDVVAAVLGAGADDVRDAVARAEAVTAVRGSEDFAAVSAAFKRMKNILAQAAEKGIAPGTAVDISLLKDGAELALAEKAAEVKPEVAALRGAHEYRGALELIATLRPQVNAFFEAVMVMDPDEAVRANRLALLGKVLGDFGGIAEFSEIVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN6</accession>
    <name>E8WWN6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582089.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70781">
        <property type="protein sequence ID" value="ADW70781"/>
        <property type="gene ID" value="AciX9_3781"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3781"/>
    <dbReference type="eggNOG" id="ENOG5033BXW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2464709_0_0_0"/>
    <dbReference type="OMA" id="VICKKSM"/>
    <dbReference type="OrthoDB" id="2084693at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9633" checksum="480FCBFA3823DDC3" modified="2011-04-05" version="1">MQVLCKISNTTSDVRCKVCGQGFLVYWSRTQRSERDQVRRQVAEALSQQHTASHAPQAHPRTGFTVSAWSGEPAAGAQPSSFTLTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP7</accession>
    <name>E8WWP7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0303</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578703.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0303"/>
    <dbReference type="EnsemblBacteria" id="ADW67375">
        <property type="protein sequence ID" value="ADW67375"/>
        <property type="gene ID" value="AciX9_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0303"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="HFMEEAQ"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="33299" checksum="5814349B66C587A4" modified="2011-04-05" version="1">MPTAEMEAVESVSRTGEAVASLENVTKNYGSVTALDGLSLKLYPGEIVALLGANGAGKSTAVRLLLGLSAPTTGTVTIFGRDPRLAATRTRIGAMLQVASMPKTLKVKEHIDLFRSYYPKPLAVKEIVRIAQLSGIEDRLFEQLSGGQRQRLLFGLALCGDPEVIFLDEPTVGMDIEARRGLWVQVRELAAQGRTVLLTTHYLEEADALASRIVVIDKGRVVSEGTPSEIKSQTASKRIRCRTALSSAQIWTLPGVIDVEQTDGWTCVTAGNAEAVLRKMFAFDEGLSGLEVVSPGLEEAFLSLTTKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ8</accession>
    <name>E8WWQ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0314"/>
    <dbReference type="EnsemblBacteria" id="ADW67386">
        <property type="protein sequence ID" value="ADW67386"/>
        <property type="gene ID" value="AciX9_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0314"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="QACLMRF"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1118" mass="118687" checksum="7569B4636F97E8B1" modified="2011-04-05" version="1">MGGDGDEGGVHFSAPFIRRPVATFLLSVAIILAGAVAYKLLPVSSLPQVEFPTISVGAALPGADPETMASAVATPLERQFSRIAGVNQMTSSSGEGSTSITLQFDLNRDVNGAARDVQAAINAARSQLPANLPSNPSYRKINPADAPIVMLALTSDTMTVPQMYDQADSILAQKISQVDGVGQVFVGGSAKPAVRVEANPTLLAGYGLGLESLRTALGQVNVNQPTGYTNGAAQRISITTSDQLFGSEAYKPLIIATDKGPVSSATASSGLPSSVASAVTSNATSANSTTAAAVSTNAAVSATPVAQAAVTGSGISSHGVVRISDVAEVVDGVENIQTGGLFNGKPAILLIVFKSPGANVISTVDNVLAMLPRLKASVPPAIKIEVALDRTTTIRASVKDVTRTLIISIVLVILVVFVFLREVRSTLIPSVSVPLSLMGTFGIMYVMGYTLDNLSLMALTISTGFVVDDAIVVIENIMRHLEMGLSPYEAAMVGSKEIGFTVLSMSTSLIAVFIPILLMGGIVGRLFREFAVTLSAAILVSLVVSLTTTPMLSAKFLKAHSEGRHGRLYVWGEKALDWMTGEYDRALKAVLKRQPLMLGITVLTFLLTVFLYIIVPKGFFPQQDTGRLGGQIRGQQDVSFDAMKIKATQMVDIVKKQDGVQNTMMFLGGGGPGGGGGNQASMFMFLSPDEERQKSGQSAEKIINDLRKKTSGIPGVQLYLQSSQELNIGGRGSATQYQYSLTSEDLDLLNEWSPKLMAAMERIPQLKDVATDQQQQGLRTQLVIDRDTASRLGVSALTVDSTLSDAFGQAQVSTIYETLNQYHVVMEVAQRFQRDPDALKNIYVKSTTGAMVPLSAITHYETLRIPLSVNHQSQVPATTLSFNLTLGASLSDATAAIEDARVAIGMPSEIHGGFQGTAQAFQASLSSEPMLILLALVAVYIVLGILYESFIHPLTILSTLPSAGVGALLFLLLFKVDLSVIAMIGIILLIGIVKKNAIMMIDFALVAERERGKTPEEAIYEACLLRFRPIMMTTMAALLGGLPLALGTGTGSELRRPLGITIVGGLMVSQALTLFTTPVVYLFFDRLRARIQRALGRTEKMQRVGVLPSEQHQTVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV4</accession>
    <name>E8WWV4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578760.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0360"/>
    <dbReference type="EnsemblBacteria" id="ADW67432">
        <property type="protein sequence ID" value="ADW67432"/>
        <property type="gene ID" value="AciX9_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0360"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893652_0_0_0"/>
    <dbReference type="OMA" id="HQCESAS"/>
    <dbReference type="OrthoDB" id="775955at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="34271" checksum="5FF148603E4CCA0F" modified="2011-04-05" version="1">MNCEGARDHIILAAYGELPDEEAIGLELHLASCQECLQELNTLREMDSLMALNPVMEPDPNFLAQSRMKLDEALDAIPQGSAWMVFRANAGAWWGHLSGAPALATLLVGVGFIGGHLTHRYQVDHAAKVPFPMVLTDTTGGGIRTVTGVQSLPGDMVQVSFERMVPEMAQGSLDDPQIKKLLMVGTMAAATPVVRLDSVVLLADQCKTGHACRSEDDGDVRKTLLTALRTDKSPVVRMKVLEGLQPYVSQDERVRDAVSQALLTDASLAVRTKAVAVLQPVQSDSSVRQALRTVSTTDVNPYLRTVSMQALGDSASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ1</accession>
    <name>E8WWZ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1499</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579872.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1499"/>
    <dbReference type="EnsemblBacteria" id="ADW68552">
        <property type="protein sequence ID" value="ADW68552"/>
        <property type="gene ID" value="AciX9_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1499"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_0"/>
    <dbReference type="OMA" id="EEYFWRP"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="21919" checksum="DCE84BA5612F6016" modified="2011-04-05" version="1">MVVAVLLGSVRSDRVGERVAKWVIAELESRGHEAVLVDPMTLKLPLLDRMWKEVKNEKGSEHAELKAKLQPLAELYQRADGFAIVTAEYNHSAPPALVNLIDYFLEEYFYRPSAIVCYSATPFGGVRAAVQLRSLLAEVGMGSIPTLQPVPAAGDALSAEGVPLTQQLAEKSGKFFDEFEWYMRALAAERKRGTPTGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX64</accession>
    <name>E8WX64_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">AciX9_2682</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581021.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2682"/>
    <dbReference type="MEROPS" id="M41.001"/>
    <dbReference type="EnsemblBacteria" id="ADW69706">
        <property type="protein sequence ID" value="ADW69706"/>
        <property type="gene ID" value="AciX9_2682"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2682"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_0_0"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="639" mass="70083" checksum="B9F876CA56058697" modified="2011-04-05" version="1">MNSTVKQLLLWVSLLACLFILWNYVAKTTGGGKEEQVSLSQLQNDADAGKIQDVTVNGNEVTGHYKDKKETFHTIIPSNYPDLYKNLREHGVGITIKDQTPSFWVNALVSLAPVALLLGLFLFMMRQMQSGGNKAMSFGKSRARLLSMQQKKITFKDVAGVDEAKEELKEIIEFLRESQKFQKLGGRIPKGVLLVGPPGTGKTLLARAVAGEANVPFFSISGSDFVEMFVGVGASRVRDLFEQGKKNAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFEANDGVILVAATNRPDVLDPALLRPGRFDRRVIVDRPDIKGREEVLRVHSKKVPMSEDVNLNVLARGTPGFSGADLANMVNEAALTAARFNRKAVHMFDFETAKDKVMMGAERKSMLLSDEEKKVTAYHEAGHVLVAALRNHSDPLHKVTIIPRGMALGVTMHLPEEDKHTVTKDYLETQLAVFMGGRCAEEIFLKQMTTGAGNDIQRSTALARAMVCEYGMSRMGPLTFGKKEGGEVFLGREIGQARDFSDDTAKQIDEEVRNFVDAGYQSAYSILDGNHDIMHRMSAALLERETLDAAEIKLIIEGKELPEARSPLSAVDPGPGGDVQKVLKPENGRKPGFEGQPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX83</accession>
    <name>E8WX83_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2701</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581040.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2701"/>
    <dbReference type="EnsemblBacteria" id="ADW69725">
        <property type="protein sequence ID" value="ADW69725"/>
        <property type="gene ID" value="AciX9_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2701"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053531_0_0_0"/>
    <dbReference type="OMA" id="FYSSYIW"/>
    <dbReference type="OrthoDB" id="1465793at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="42064" checksum="DDAD2A8EC4F0A69F" modified="2011-04-05" version="1">MSRFIGLDELAARASVLSRGAVASLFLAATLCLGIAPSHAQTVQLSRTELPDSPGHLRDLELQATAAQQTPNAPQTGTASIRGVVLDVNQGIVPDAKLTLTEHGVSGDRTAISGPDGIFTFADLPAGRYNFIVTSAGLETFVSSEITLKEGQHYEEPKIALPIATASSDVTVRVTERELAEEQIKAEMQQRVLGIFPNFYSSFIWDAAPLEPKQKFEMALRARSDPFVFLVTGIVAGVQQARDKPSAWGQDLPGYAQRYGAAFTTGTVSRFFGSAIYPVVFHQDPRYFYKGSGSVSSRAWYAMTRSVVARGDNGKWQPNYSHILGGMTAGAISNLYHPASSRGAALTFENAGLGIGFTAAGNLVREFVLRGVTHKVPTYEQGDKSSGKSAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA6</accession>
    <name>E8WXA6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase, subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0367"/>
    <dbReference type="EnsemblBacteria" id="ADW67439">
        <property type="protein sequence ID" value="ADW67439"/>
        <property type="gene ID" value="AciX9_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0367"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_6_2_0"/>
    <dbReference type="OMA" id="KNAHKER"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="126"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="593" mass="65544" checksum="5C7A3AC7EA0A1137" modified="2011-04-05" version="1">MSDTANLRRLAASQPRTILLEDSRPSSARSFFFQSPVEWLEVHTLDDLPGLFTRIQTAQAEGLWAAGYLSYECGLHFEPKAVPHVPGPIPLAAFGLYTAPNLFTARPTPEAPSSGLNDLPFNITPEAFTAKIAQIHRWIEAGDTYQLNLTDRILAELPGTPAELFAHMMQTQPVEFGAFLNLGDGQTILSASPELFFHLDQRHITVRPMKGTAPRGRTPEEDALNAQTLAADPKNRAENLMIADLMRSDLGRIAEMGSVRVDKLFHVEPLPSLLQMTTEISATLRPEITPYDLFAALFPAGSIVGAPKLRSMQLLRTLEARNRGVYTGSIGFFSPHGEAVFSVAIRTAVLHGKQLEMGIGAGITYDSDPAAEYAECLLKAEFLREAPTTLIETMRWENGTCTLLPLHLDRLEASANHFKIPFDREAILKTLQQADPSSPTRLRLTLNRTGINLTSAPIHPDPPALKAMLWPKPVTSTDPFLRHKTTRRALYDQAHQAATAQGCIDAIFQNEQGHLTEGAIHNLFLRHGGLWRTPPLESGVLPGVYRRHLLETQPHIQQAILTLADLRSADEIWLTNAVRGIRNVELEPPFPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH3</accession>
    <name>E8WXH3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0434</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67506">
        <property type="protein sequence ID" value="ADW67506"/>
        <property type="gene ID" value="AciX9_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0434"/>
    <dbReference type="HOGENOM" id="CLU_215851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="41" mass="4037" checksum="E5928C2D26300AC2" modified="2011-04-05" version="1">MALDGGLKPPSNPNGNGNGNGNGNGNGNGNNNGNNNNNSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK8</accession>
    <name>E8WXK8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1571</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579943.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1571"/>
    <dbReference type="EnsemblBacteria" id="ADW68624">
        <property type="protein sequence ID" value="ADW68624"/>
        <property type="gene ID" value="AciX9_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1571"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_1_0"/>
    <dbReference type="OMA" id="INTRHIR"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="32749" checksum="637C5D4CDD493DC0" modified="2011-04-05" version="1">MANPKQKKHVPTPRQYPPRPPAGPPEVVNPIWLLKAVGITIAAALICAYLTLCLLVYQGQWQLVLHPTVSTEALTLPDATTIRFGAAETGQPALSGLYLPASTPSDRTILYLPDATGSLAANAATLTQLHTLPLNLFAFDYRGFGASARTQHPTELRMTEDAESALDYLINTRHIRPQTIVPYGVGLGASLAATLAARHPELPAVILESAVPDVLTQARADSRAGLVPLSLLFHEQFLIAPTLSTLTTPKLLLTTGPSPITPHATPETLYRNAHAPSRTTHLISPQDPQFPTVIQRFLDEYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV6</accession>
    <name>E8WXV6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2778</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2778"/>
    <dbReference type="EnsemblBacteria" id="ADW69801">
        <property type="protein sequence ID" value="ADW69801"/>
        <property type="gene ID" value="AciX9_2778"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2778"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082418_0_0_0"/>
    <dbReference type="OMA" id="CGKGRML"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="27616" checksum="B04E1A012C9F7CD2" modified="2011-04-05" version="1">MNAPTKRARRKVVPIHTPKLPPTHPFDRVHHTDTGGLIERTQLITGHANDAHVTAYYGIAPSILDAVIDLWQGTRPKYPIDRYTFVDIGAGKGRAVMTASLHPFFEAVGIELNPTLASIARTNLQTFPNYANPLAPTRLIEGDALAANLPLTPTLAFMFHPFEAPVLRKLIGKIQAHYSVLDLPFDLIYVNAEHASVLDQNTWFKRLFHGLVPMSSVDHLADLAEIAEQTEYGSTGDEICGIYRFTGPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW1</accession>
    <name>E8WXW1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2783</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581121.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2783"/>
    <dbReference type="EnsemblBacteria" id="ADW69806">
        <property type="protein sequence ID" value="ADW69806"/>
        <property type="gene ID" value="AciX9_2783"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2783"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_3_0"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16701" checksum="FA4A30815FA6DC0C" modified="2011-04-05" version="1">MPEFNREKRFKTRSERGTLAIAETIAEMLPAPRVIILRGDLGAGKTTLVKGWVQALGAGSPEDVTSPTFTLVHEYQGRKTHIYHLDLYRLETERELATLGLEEMAADPAALVLIEWGEKFESVVALARAEVAMAHLEGDERSLDIRWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ5</accession>
    <name>E8WXZ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A24A prepilin type IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0462</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578862.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0462"/>
    <dbReference type="EnsemblBacteria" id="ADW67534">
        <property type="protein sequence ID" value="ADW67534"/>
        <property type="gene ID" value="AciX9_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0462"/>
    <dbReference type="eggNOG" id="COG4960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_4_0_0"/>
    <dbReference type="OMA" id="DVKLMAG"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19029" checksum="187D9174D0FC038C" modified="2011-04-05" version="1">MVINPQTTYLTAALVCASIGSLHDLRSRRIPNRLTGPAILCGLLLHLALGGWTQLGLSALAGLIAGGIFLVFFVAGGMGAGDVKLMTAVGCLAGTAYIKEVLIATVLIGALMGVALALYRGRLRETMLNVITLVQHHGAEGLAAHPELNVRNVATLRLPYALPIAAGCLLTFFMTSGKELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY62</accession>
    <name>E8WY62_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1637</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580008.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1637"/>
    <dbReference type="EnsemblBacteria" id="ADW68689">
        <property type="protein sequence ID" value="ADW68689"/>
        <property type="gene ID" value="AciX9_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1637"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="DCTKEEF"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="31333" checksum="F02C9635CA11C2A3" modified="2011-04-05" version="1">MPPTLPNPAPENAPDTTPIVAFHDVSIAFDSDRPILNKISFEVARGQTLIILGPAGCGKSVLVKLVDGLMKPDSGSIKVFGEELTTMRERDVYTLRKRIGMVFQESALFDSMNVEDNVAYRFNEAGMDPSESHKKVEEVLNFVELPKAISKFPSELSGGMRRRVSIARAIITNPDLILYDSPTGGLDPITSTTIVELVIKQRDVSHTTSLLITHRLQDAFTLATHRWNVNDNKMEPIPRNEMDNGIDDSTQFLVLNEGTVVYHGNTQGLVHSEDPWLKDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA4</accession>
    <name>E8WYA4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1681</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1681"/>
    <dbReference type="EnsemblBacteria" id="ADW68731">
        <property type="protein sequence ID" value="ADW68731"/>
        <property type="gene ID" value="AciX9_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1681"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_8_0_0"/>
    <dbReference type="OMA" id="EASKHRQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="35260" checksum="D96000D34012C191" modified="2011-04-05" version="1">MLPILLEMRPTLNLLTTFSPTVQGSIFQTLNHDWHQDFVVMVEDRLPKVAVVLVFLFILWRVALFFVHRMQKLAIRQVGNSQRAAQLRTMATIVRATSLSALGFLGFLQVLNLLNIDYKPLLASAGILGVGIGLGAQSLFKDIINGIFILVEDQYNVGEVVKVASLTGTVEDLTLRLTRLRDGDGTLYVIPNSQIATVSNLSRDYSVASLPIAVDASANPDEVIALLGEIAAGLRADVAFKDVIVADPSVLGVDKIDGRSIIYPINIRVRPNQKDGVLRELRRRVVLTFEKRGIPLGSDSSMLIMQAAKDPTAPPSQQPLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD7</accession>
    <name>E8WYD7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2820</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2820"/>
    <dbReference type="EnsemblBacteria" id="ADW69843">
        <property type="protein sequence ID" value="ADW69843"/>
        <property type="gene ID" value="AciX9_2820"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2820"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490742_0_0_0"/>
    <dbReference type="OMA" id="YGMEMLP"/>
    <dbReference type="OrthoDB" id="276460at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="110"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="554" mass="61169" checksum="B0F7320FC05D2E54" modified="2011-04-05" version="1">MSTRGRRGRRGGPLVQGPPRDPDAVTPALREDMLPISMGAVVLGFIAIAISAMRGTMMLYGDAVAHLGIARRIVDTKYPGLAQLGGVWLPLPHLLMTPFIWKMEWWQDGMAGAWPSLICYVVGVLGFYRLARRVLVPRWALVATAFLAMNANLLYLTSTAMTEPLFLALMIWITLVTLECVEAIEAARPLGAGRRMLGLGVLIFCAVMTRYDGWVLGAAVWCVIAWTLWKEPAMRAKLAGVFVGFTLITVAGPLSWFAYNHVYGHDWLDFMRGPYSAKEIDRKTSPPGSHHYFGWHDPAWSLMLYARTAQVDAAAWETGWLVAAASLAGLWLTIKSKVRWSALLLWMPLPFYVYSISYGSVPIFIPQLYPHSYYNSRYGMEMLPCFALFGAVGLSALAVWLKPRQPLVVRFMQPVMLMLIVLNTIWMLHKTPLVLKEAQVNSMGRISLETALANQLVTFAPGAPIMMETGSFVGALQKAGIPLKQTLTPSDYYKGLTTPAEKAAYVISFAGDDVAKAVTAHPEGLTEMTILCSTGQPCARVYRSDRFLGAGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF0</accession>
    <name>E8WYF0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2833</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581171.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2833"/>
    <dbReference type="EnsemblBacteria" id="ADW69856">
        <property type="protein sequence ID" value="ADW69856"/>
        <property type="gene ID" value="AciX9_2833"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2833"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_0"/>
    <dbReference type="OMA" id="RGHVREK"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="155"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="261"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="411"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="477" mass="51564" checksum="B0F4ECEC4EC4C242" modified="2011-04-05" version="1">MGVVKFGTDGWRGIIADDFTYENVRVAARAIAHYVIEQEDASKGVCIGWDTRFASQAFARVVAEVLTAAGIPVALASIVTPTPALSYAVRERGAAGGIMITSSHNPAQWNGVKYKASYGGSGKPSIISAIETYLEKPLAAAAEPAKLEEVNFNPPYVEAIAKFVDLPAIKASGKRFLIDCMYGAGRGIISGIFAEAGVPYVEMRAEINPDFPGINPEPILPHIAETQKRVVADACDAGLVTDGDADRIGAVDEHGNVVDAHKIFAILLQWLLERKGWPGDVTRAFNTTKMLDRIAAKHGRKLHEHGIGFKYVCDLMLTENILIGGEESGGIGISKHLPERDGLLNSLLLCQVMADEGKTLGELVAALQAEYGEHQYNRIDMHINDELKQSAIKRASAIKAGDDFAGMKVNRVETLDGIKFYLENSHCTDKVNAAETWLLLRASGTEPLLRVYCESCSVESVNAVLKVAEKFVLEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ5</accession>
    <name>E8WYJ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0521</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578921.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0521"/>
    <dbReference type="EnsemblBacteria" id="ADW67593">
        <property type="protein sequence ID" value="ADW67593"/>
        <property type="gene ID" value="AciX9_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0521"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="KYLMSHP"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="25772" checksum="33EB7DB6744D1F24" modified="2011-04-05" version="1">MRILVVEDEPKVSSFVQRGLVAERYAVDVSADGREGLELAQAFPYDLIILDMMLPRMDGGEILQRIRRTNTCVPVLMLTARDSVEDKVRMFENGADDYLTKPFAFAELLVRSKALLRRGPVNRSSTMTVGELELDRLTQQVKRAGKRIELTAKEYSLLEYLMQNAERVLSRNMIIEHVWDQSFDGITNIVDVYVRHLRAKVDDGHIIKLIRTVRGSGYMIRAGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X018</accession>
    <name>E8X018_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1868"/>
    <dbReference type="EnsemblBacteria" id="ADW68914">
        <property type="protein sequence ID" value="ADW68914"/>
        <property type="gene ID" value="AciX9_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1868"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270615_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1202" mass="129499" checksum="2E07EFA22CDBD3AF" modified="2011-04-05" version="1">MSTGNNKSTPEGLASPASAMNVQRAESPGFDPELMRSLRMRPRLAAWVAVAVFVIVVGFALSRKSIYSAQSLTYVEPQTAKVLGDTSTGAFDAGRYDSYLQQQMQTAIRPDILTAALKRLPVGAFQFPHESDQSAVARLQKQLKVERVLNSYQLSITLQGSDAESVAATVNAVTNAYLEQGRKDEHETSSQRLELLTQERQRIQSELSEDRTEQATLSSSLGVANPVGETGNPYDVQLAGVRTQLAMARSAHDVALAQLSSVRGNGGAETAGLNSAADDVLQNDAGLASLKSTINQRKALLSSQMAGLTPSNPVYKQDQDEMSDLDRSLDKQTSQLRQQAAKRVEDKLGLELQRTASVEGMLNAQLAHQTATATGAAPKLQRASELYSDITRLTARFATVEDAIRGLQLEANGPGLAHLSVAASVPLSPEPSKRKLLLLLALPLALMMGAAAAVLAHKRDPLVYTEHDLQTVLGFPPIGVLPSRDEVSSATIEEYVLRLAAGIETAYRVSDARSFVFTAVSPSVSVTGLVLVLQEKLEELGFTVLITEAPTLLQPHVGGVPMPRLKVDAGSGSIALRHNEGHEGYAATNLTMLKRSHDLLLIDAPPLLHSAAAEYAVRSADAAILIAGSGLTLRTELTQAATLLDRLNVAGVGAVLKDLQLKHADPSFKNAIAVLETRWNAQAQDAARSVQAKRAAQRGTPVPASQAPATPADSLQYASHAASTIESDRTEVQHEAFGHHEAPEPVSSYVEPAPLAEEWDGSLDEPVAAAPSHHFDMHSFDETHEEEQYPHAREHDFVPLAAAMQEPHVAHEVVNAGHAVDDEEEQIASAVTPLHQHVNEPETAEPVMTTESPRNNLVFEPEDEPSERARVWLERLLNPNAASQAAPHSAAQPEPAVLETTVEPAFEVASASPVVEAAPEPEPVVEEPVPALTTPYEIIPMHVHHSVEAEMGSAPEAHAEEVTEVIEEYPVFHEHHPSEPVQHGMEEAPHHAQASPVHIVHAELAPEEEIAAEDPPPSPVWTPHHFEPVAHVEQEPIAAAEAEPVVKTEALAIAEEEKFEAVHEVYEEPVFAEPVAEPSRSSVVEEPEFIVSPPVPERWAPIPEAAPVQHVQHAPELEPVQEPRAAINGIRRAAELRETSTSASTAKLPARSEGTIQPETGRMTRSWGMLSKFGGEAHTGNRSRNYTSAPDAEEALEERSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X050</accession>
    <name>E8X050_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ordered locus">AciX9_1900</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580265.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1900"/>
    <dbReference type="EnsemblBacteria" id="ADW68946">
        <property type="protein sequence ID" value="ADW68946"/>
        <property type="gene ID" value="AciX9_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1900"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_1_0_0"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="27143" checksum="FFCDD36152A4AB07" modified="2011-04-05" version="1">MKFVVKLGGAALEDPKLLHLAGKALKDLVEDGHQVAVVHGGGVQLTRTLAQMGKVSEFVSGLRVTDAETRDAALMVLAGRVNKSLVAALGQHGQSAVGLSGGDGHVFRARKKITTPDLGFVGEIASTDPRWLDAIWKMGAIPVISSIALGFDGEYYNINADEMASACAIATKADALVFLTDVPGVKGADGQVMRWLTLKEVPTLEKSAVISGGMLPKLAACKAALTHGVKRVRILPAEAAASLPDLISSRINEGTEVMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D6</accession>
    <name>E8X0D6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ordered locus">AciX9_0730</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579126.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0730"/>
    <dbReference type="EnsemblBacteria" id="ADW67800">
        <property type="protein sequence ID" value="ADW67800"/>
        <property type="gene ID" value="AciX9_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0730"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_1_0"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="368" mass="39952" checksum="6D347A0B69B282D2" modified="2011-04-05" version="1">MLVSDFDYELPEELIAQTPPETRGASRMLRMDRASGALVDDSFASLPECLKAGDLLILNDTRVIPARLFGVRAGLHTQHNSPAPTGRIEVLLTSQISADDEGSTWETLVRPARKVQPGETLHFYDAERPSAPALTAEVLAAGEFGERTLRLIPADPQEPLTAILERIGHLPLPPYIYRPDEAPNTTADRERYQTVFAQPAGSAAAPTAGLHFTPEILAALKARGVEVQTLTLHVGLGTFQPVRAERTEDIRLHAEPYTLPAATAEAIQRAQAEGRRIVAVGTTVTRTLEHCAAIGNLAPHSGTTSLFLSPGHEFRVVGGLLTNFHLPQSTLVMLVSAFAGREATLAAYAHAVRERYRFFSYGDCMLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E7</accession>
    <name>E8X0E7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0741</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579137.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0741"/>
    <dbReference type="EnsemblBacteria" id="ADW67811">
        <property type="protein sequence ID" value="ADW67811"/>
        <property type="gene ID" value="AciX9_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0741"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115776_1_1_0"/>
    <dbReference type="OMA" id="CGEGIWD"/>
    <dbReference type="OrthoDB" id="1947977at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022452">
        <property type="entry name" value="MqsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032758">
        <property type="entry name" value="MqsA/HigA-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15731">
        <property type="entry name" value="MqsA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03830">
        <property type="entry name" value="CxxCG_CxxCG_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14473" checksum="39637A57B58BC48B" modified="2011-04-05" version="1">MKCPNCGDAKLVRGVREMPYSYKGESTVLGEIAGSFCAACGETVLDAPEANRVSALMLEFNKQVNASMVDPEFISRVRKKLALDQREASVIFGGGVNAFSRYENGKTKPPVALIKLLKVLERHPDLLAEVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X5</accession>
    <name>E8X0X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3147</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581472.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3147"/>
    <dbReference type="EnsemblBacteria" id="ADW70159">
        <property type="protein sequence ID" value="ADW70159"/>
        <property type="gene ID" value="AciX9_3147"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3147"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_28_2_0"/>
    <dbReference type="OMA" id="EGRIWIA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230538" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="888"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109979" checksum="D68B05157B9298C9" modified="2011-04-05" version="1">MPVKKSLQFIAVALLLAGGVTSRALESDAQLSQLGHTAWRIRDGAFNGAVNDVTQTADGFLWIATDNGLLKYDGVRFVHVGSGSILALQAAQDGSLWFGTGQSLFHMRSGQVEKLQGPDVHVNNIRQDVHGTIWFTRSRSNSGPLCEVVGSKFHCLTAADGVTLPYAEALAADARGDLWVASGSRLLRGHSGVFQEYPHPELSAAETSNGIESLTPRADGSILVGITRAGSGLGLQSLKDGIWHDAYSEPVSSSAWSVTSTLVDRDGTAWVGTSDKGLFRIRQDGIDHFGESDGLSGNTISSLFEDNEGDVWVGTKKGLDRFRNLFVKTFSTTEGLGSDSVHSVAAASQGGVWVGNKGSLSTLRNGKAFNYFPKTGLPGQRVTALLEDHAARLWVGVDADLYVFDKGRFTRVLDSEGHATGAVVSIQEDTEHNVWVLASRRPYVLLRLSPTSRQLQVQPLRFDPYAIVADPAGGLFIDGGKHGSPLIHFQQGSIETWTPKTKIQRTSFAFAKDGSKWASTSSGVELFNRQDSRFLDKSNGLPCNHVFSVVFDKSENLWVYSECGLVTIANSELSKFESDSRYSVRSHLFDIFDGALPNGADFAPRVTRSTDGWLWFANGTDVQEIDPSHAQLVAAAPNAEIDAIVARHVEQEAVSGMKLPALTRDVDLRYTAPALAIPERVRFRCRLDGHDKEWQDSTKLRDAFYTDLRPGDYTFRVVSGDADGNWSRKEAQFSFTILPAWYQTKTFLAVCAALGSLVILLAYRLRSRQIRREAQARYDERLAERTRIARDIHDTLLQTIQGSKMLADAALVQMSEHDQAQPRVQMLSTWLGNAMEEGRTALRSLRTPVIEQQSLETLIQDALDDCALSSKIVTALNVDGEPAAMSVCVREEVYRIAYEAITNACLHSKGKRLDVVMTYGEAFELRVKDDGAGIASEFVKEGRLGHFGLAGMRERARFLSADLTFKASPGDGTEVLLRVPRSSLLESARPSIWVRFVRLIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z6</accession>
    <name>E8X0Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3169</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581492.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3169"/>
    <dbReference type="EnsemblBacteria" id="ADW70180">
        <property type="protein sequence ID" value="ADW70180"/>
        <property type="gene ID" value="AciX9_3169"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3169"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_23_1_0"/>
    <dbReference type="OMA" id="LFPAKEQ"/>
    <dbReference type="OrthoDB" id="1826886at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="22042" checksum="EB192CBF02B1C7C8" modified="2011-04-05" version="1">MNLMNSQKQSEPRERILEAADRLFYTEGVRATGTEKIMSVSEVAKATFYRHFPSKDDLVTAYLEYRDRSFFEYLDSPAPPEDIHEALARIERVVNRVDIIGCPFLRIASEYPDFDHPFHRIAVEHENKFLAYLINLLKPYAFDKKVVAAALLSVVDGGLTTRMLYGTSKEVPILSPAGAVLKSFQVARTQRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X165</accession>
    <name>E8X165_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579256.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0863"/>
    <dbReference type="EnsemblBacteria" id="ADW67931">
        <property type="protein sequence ID" value="ADW67931"/>
        <property type="gene ID" value="AciX9_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0863"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_17_2_0"/>
    <dbReference type="OMA" id="HAGWARR"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="44774" checksum="BB86E3EDC57BBC64" modified="2011-04-05" version="1">MSRYAPLAEPLIATPPHPKLRACIIIPTRNEESILPRTLDALRLQQSFNHQPLDPNTYEVILLLNNCTDASEAVAQHYQQQHPTFHLHTATRTLAPEEAHVGTARRLLMDTAHHRLQTSPHSYSAILSTDADTVVAPDWTARNLAAIEAGADVVGGVINLFPEDLEALKQQDPGTYQAYKNDRQLQHLVAQLESILDPDPADPWPRHLEHFGASLACTPSIYALAGGLPPVKPLEDVAFIDALRKVGARIRHCPQTHIFTSARLDGRAEVGLSGQLRIWQNQSRNKEPHTVDSAQWLEHRFRSLAALRRLNQSQHLPPLTLYPQPWQDRITNLHADRLPTPRFLELLDCNALIEDLFTQTNHPHHSEIEETITALTQTITTLTHKSPGTPSEPLHLSVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A4</accession>
    <name>E8X1A4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2013</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580376.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2013"/>
    <dbReference type="EnsemblBacteria" id="ADW69058">
        <property type="protein sequence ID" value="ADW69058"/>
        <property type="gene ID" value="AciX9_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2013"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_0_0"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7913" checksum="CE1A1ED80C8143AC" modified="2011-04-05" version="1">MAHFKGEVKWFNNAKGFGFLGREGEPDVFCHYSSIQTDGYKSLKEGDKVEYDVILGDKGLQADQVVRVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H8</accession>
    <name>E8X1H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581525.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3202"/>
    <dbReference type="EnsemblBacteria" id="ADW70213">
        <property type="protein sequence ID" value="ADW70213"/>
        <property type="gene ID" value="AciX9_3202"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3202"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_0"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="28412" checksum="92687C79D630949B" modified="2011-04-05" version="1">MEVLYGLHPVEEAIRSGGRRLEYVLISRDRRDKGDDRLTKLVELCKLAGVRVSIEPKDQLTRVAGTDAHQGAVAAVRERQFLAIEDLLAAKGNFDKRFFLALDGVEDPHNLGALLRSADGAGVDGVVLPDRRSAPLSGVVAKTSAGASEHVKIARVTNLVRSLEQMKRANIWVLGLDERGTPDYTAFDFNSDCVLVLGSEGTGLHDLTKKTCDHLLRIPMAGSVSSLNVSVAGAVVMYEALRQRSQPLPSALKPVKPRKGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X8</accession>
    <name>E8X1X8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2095</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2095"/>
    <dbReference type="EnsemblBacteria" id="ADW69139">
        <property type="protein sequence ID" value="ADW69139"/>
        <property type="gene ID" value="AciX9_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2095"/>
    <dbReference type="eggNOG" id="ENOG502Z9TY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766760_0_0_0"/>
    <dbReference type="OMA" id="AIHRNFI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="34516" checksum="8E91AF79A8192EEE" modified="2011-04-05" version="1">MNVVTRWCFAFGVGLLWGRAARADVVLVMEDPINFAGRMTSAGHSAIWLDRLCSDDHIKMRSCGAGEPGAVLSRYQGVKGRFDWLAMPPDAYFFAVDRESAIPANVTAENAERLRREYRVAHGGSFAVDPGDGTWTSLLGESYRRRIVLVRVRTTGAQEQRMMRWLNDGRNVSHFNMFYSNCGDFASKLLNVAFPGAVHRNYLLDAGMTTPKQLEARLHGYAKRHPELGWEATLLPQVAGSIPRSRHLHGVTESYLKTYPYLLPLDYLLPIELGLVTGLGLCDHRYVAKPNVRVDDGIFFPTAEVAGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X203</accession>
    <name>E8X203_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ordered locus">AciX9_2120</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580480.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2120"/>
    <dbReference type="EnsemblBacteria" id="ADW69164">
        <property type="protein sequence ID" value="ADW69164"/>
        <property type="gene ID" value="AciX9_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2120"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_0"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="30871" checksum="2162B171B13CB465" modified="2011-04-05" version="1">MAQAKKRIGVHLGTSGGCWTAVNRAVEAGANTFQFFSSSPRTWKANAVKPEEAAKMRELRAANDIGPVAIHASYLINLCSQTETVRINSTAAFRGEVERALAWGAEYLVLHPGSWKGLTRDEGLRLAAASIVEAVDGIDFTGKDFRILIENTAGAEFSLGGKLEQVAELVETLKPCAPVGVCLDTCHVHVAGYDIVTPEGYAETMQTVEQTIGFEAVKVWHCNDAKAAMGSKLDRHEHIGEGTIGAEAFRRLLHDQRFAGAVFIAETPVDAPGDEARNVGVLRTLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X225</accession>
    <name>E8X225_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3257"/>
    <dbReference type="EnsemblBacteria" id="ADW70268">
        <property type="protein sequence ID" value="ADW70268"/>
        <property type="gene ID" value="AciX9_3257"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3257"/>
    <dbReference type="HOGENOM" id="CLU_2601152_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="7814" checksum="EA1737621AAAF02C" modified="2011-04-05" version="1">MGLGGSAGSGFGVVFGRVAGKARPGLKPLLLFRPVDGGLKPPSNPNGNGNGNGNGNGKCKCNGKYGGSGFARMTTSLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X235</accession>
    <name>E8X235_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3267</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581590.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3267"/>
    <dbReference type="EnsemblBacteria" id="ADW70278">
        <property type="protein sequence ID" value="ADW70278"/>
        <property type="gene ID" value="AciX9_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3267"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_0_1_0"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="235" mass="25314" checksum="B38DE5DEE8545FB7" modified="2011-04-05" version="1">MSIAENLAHLHDQILAACARANRNPADVALMAVSKMHPVDLLLEAHAAGQRLFGENRVQEWQGKSEIAGTLEDLDMHLIGPLQSNKSTRAAELFHSIDTVDSLKLAQRLNAAAGALGKKLPIYIEVKLSPEESKHGLAPADLPALIEALPSLTHLRPTGLMTVPPWPADIAQAGDEARPYFRELRRLRDQSQRTIPTLTGLSIGMSNDFAAAIEEGSTCIRIGTAIFGKRAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X255</accession>
    <name>E8X255_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_3287</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581610.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3287"/>
    <dbReference type="EnsemblBacteria" id="ADW70298">
        <property type="protein sequence ID" value="ADW70298"/>
        <property type="gene ID" value="AciX9_3287"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3287"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_0"/>
    <dbReference type="OMA" id="NWEEWAT"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234100" evidence="8">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="9">
        <location>
            <begin position="324"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="552" mass="60206" checksum="69E9D33DE9E024A7" modified="2011-04-05" version="1">MNRSLLRPAAAIATALFLLSSAPAQEQAGDKVDLDVLAKIKSQAYDHSQVMENLYSISEVYGPRVNNSRNHRAAAEWAVTQLKAWGLQNVHLEKFDFGYGWQIKKFYAAMEAPAYAALIGFPLAWTPGTNGPITADAMYAPIHSKDDFAKYHGKLKGKIVLMFDPPHLLLHTTQDATKSPTDEEILARANAPRGGAAPAGRGAAPGGPTPRGRGRVDEGTWEYTPTSLALADEKNHDLRNEINAYLHDEAPAVVLTPGYNGDGGTIFSSYGGSQDPKDPVPPPIVAITPEQYNRIVRLLQHGTTPKLTFDVAVDYQKDDQRAYNVIGEIPGTTKKDEVVMLGGHFDSWQGGTGATDNGTGSSVAMEAVRILTTLHQPMARTVRVALWGGEEEGEWGSKAYVQQHFAPRDTMKQTPDYAKLDVYFNDDGGSGRFRGVSAGGSPQMAAIFKSWIEPIKDQHIVAVSNADTFRPTLTPGGTDSSAFSWIGLNGIGFQQDGLEYGTRTHQSNMDLYDRVQQDDVMQGSMIEAWFTYNAATRAEMLPRIPTPEPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X258</accession>
    <name>E8X258_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_3290</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3290"/>
    <dbReference type="EnsemblBacteria" id="ADW70301">
        <property type="protein sequence ID" value="ADW70301"/>
        <property type="gene ID" value="AciX9_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3290"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890718_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="35011" checksum="2D034643C0201C2C" modified="2011-04-05" version="1">MTTAQQRLRCRPEQARKRRLRLGSAESRSHFTAPRRRFRVPTKVCTGQLRRPNSSQRRAQNLLPKMVFHDRAVYQVEHAAQLIMARRLDPPPKGRIHLRRPVDVALRFSLAVVRRTIHLRAFERAAVEPYTPRMLRRLSYLAVTACSLTAMGQQQPFTGESRPAPVIVDVKPSPYPQLAFAAHVSGVVKLDLAVRHDGTIQSADVISGPAMLRQAALGAVQQARFDCHDCDEATTQTHVTVQYTLGEVRPCPAAEESSTAFIEKATYLQVTHSDDAISITERPIGTCDYAATISKNSARSVKCLFLWHCGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X263</accession>
    <name>E8X263_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3295"/>
    <dbReference type="EnsemblBacteria" id="ADW70306">
        <property type="protein sequence ID" value="ADW70306"/>
        <property type="gene ID" value="AciX9_3295"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3295"/>
    <dbReference type="HOGENOM" id="CLU_749568_0_0_0"/>
    <dbReference type="OrthoDB" id="1229011at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="369" mass="40196" checksum="774E99CFC7C132DB" modified="2011-04-05" version="1">MPDPENQQDPQPQERVNASALTGAVALFCGGFILVASLLHLTLRDPLHLHADVRSEKLVMMERLHGPVSSAAFGTSRVHNGFDPRAFDAVLGTRSMNLGIEGGSQAEQRTMALEFTRQLKPQPGTPCLILLELTAGANFQNEHLVHPRAINIYDWSTARFIAHLSNSRMPLIQRVGRTGFALAATALHYFNIGMISNEVFTPPLDQDILADELKDNQRGLKIDPFSAHERPGIDERFRQRPAQPELTPGNLTPGNSDLIADLIAANPTRNLSFAYFTLPVTGDLALAETYPDHLTVSGRDVPILNLGRPDLFPALFQTDMFHDIGHLSKAGADAFSQTLAQQLKAWYATHGGPPPCSVSATKPGPEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X281</accession>
    <name>E8X281_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0946</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579337.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0946"/>
    <dbReference type="EnsemblBacteria" id="ADW68013">
        <property type="protein sequence ID" value="ADW68013"/>
        <property type="gene ID" value="AciX9_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0946"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847114_0_0_0"/>
    <dbReference type="OMA" id="VAHEPAN"/>
    <dbReference type="OrthoDB" id="1439083at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="42466" checksum="88DB1B7A9F2428AC" modified="2011-04-05" version="1">MELLPTSLGTRPRLAVEIRPEGVVAARAEDAQALVSAVSHGIFAEGTLAPGLKPGNLVARTAVIGAVKKALEAVALKERQVTVVVPDAAVRVLLLDFDALPAKVVEALPVVRFRLKKLLPFDADDAMVSYQVMSTSRNLVRVLAVAVPKDVLHEYEGVIREAGFEPGAVLPSTLAALAGMTEADTASLVVNAGESAVTTAIVRGGVLLLHRTVDLAAEGMHDLVEAAAIIPVAPVLEVPVELLALPLVDAETSAGEWAMQEPVTGYGVLDDHHIDQAERLAQTIMAEAAAEIAELERLDHVAVLPIALTGLEIEEARLTAAAREVTQAVSVAAAYFEDTLESSPGTILAAGTMGADVLCRLLREAGFGADEIRVRETVEATMLTGGAVTTRVPPGWMAGVRGALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X298</accession>
    <name>E8X298_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0963</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579354.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0963"/>
    <dbReference type="EnsemblBacteria" id="ADW68030">
        <property type="protein sequence ID" value="ADW68030"/>
        <property type="gene ID" value="AciX9_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0963"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_7_3_0"/>
    <dbReference type="OMA" id="SAVAEMY"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="16134" checksum="E04FCE7ED0812727" modified="2011-04-05" version="1">MATKRKSRGGYMISVVAEMYEIHPQTLRMYEREGLLRPSRSEGNTRLYTDEDLERLEFILNLARDLGVNIAGIAIVLQMRERMEEMNRQMQGFVDYVREEMLTRINQQQNPGAGLVPLRRAGLVPIKGTVKDVLKAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C0</accession>
    <name>E8X2C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579376.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0985"/>
    <dbReference type="EnsemblBacteria" id="ADW68052">
        <property type="protein sequence ID" value="ADW68052"/>
        <property type="gene ID" value="AciX9_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0985"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_4_0_0"/>
    <dbReference type="OMA" id="YEGMGHG"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="23235" checksum="208060C9AFA5A7B5" modified="2011-04-05" version="1">MNSLDPHAKASVVQFGAPLSEAIGVMILLHGRGGSAQDILSLARSLYDPRLCYLAPQAANHLWYPNSFLAPRETNEPDLSSALRKINSLITEAAEAGIPTERIFIGGFSQGASLSTEFVASHPARYAGLMTFTGGLLGPLGTDISHEGDLAGTPALMFCGDPDPYIPWPRVEESAVVLRAMGADVTTYRYPGRPHIVTAEELALAAEMVKTAIANFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G0</accession>
    <name>E8X2G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2140"/>
    <dbReference type="EnsemblBacteria" id="ADW69184">
        <property type="protein sequence ID" value="ADW69184"/>
        <property type="gene ID" value="AciX9_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2140"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="TQEYTTT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Pro-kuma_activ" evidence="2">
        <location>
            <begin position="70"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1292" mass="129087" checksum="4A1B069DBAA95A94" modified="2011-04-05" version="1">MRSFLLPFTPLNATIPIIMKSKVTRSLRRLVSTSFAASALVALFSAAIPASAQQSGDTRVTLATRTAASLAAATDAGPLPAAQRLSLTLTLAPSADRTAALQQYLADLTTPNSGSYHKWLTPQQFAASYGASSDQLATATTWAQSQGLSVDAVSPSNLRLTVSGTTTQLQSAFAVSLHAYTVAGAQYFASTTLPSLPASTASVIAAVDGMDNLPANSALILNTAPATLSSIASVVDANTTPILTLTSALCTANLSTGQLAEYTTLLRQASAQGITTISSRDCPSGSFPAALSEVTAVSAPGAVADTTAPIAARPSWQNAPGLPADSLRYAPDLTSASLTSFAQTIAALQQKSGSRLGNINQTLYALLPTPGLYTQPDAAKDTWEPATGLGLIDLQKLAQAFPLGTAGVTLNYYSSNGAPIHGQTFTLTTTLISSTGGATPTGSITYAANSAVFTSATVNLDGNATATSAPYQLPGGTYAITATYSGDANYAANSATINLTVSPEAAAYTITSPATATLGDTITTTVTLKSNSGFGTPVATATITPFGLTNVNPVNVGINGSNGTATGSTTFTLNAAGTITFKVNCFPSDQNFTCDGTQQTTTQVAHVTPVVTLTLNPSVLTTGTPTTLNAVVATTGGIAPTGNVQFFDNGTQLGTGNAPNATLPNITLAPGTVHSLYATYVGDDNYNLANSNTVTPTVSSVATTTNVTVNPTAPVFGQALMLNVTVVPTAVINGTQPTGTLTIAGAGTTFTAPVTGGTATVKLPALPIGNYTVTTAYGGDTVYAASTGNPVTFTVGATVGALMTDLQPPSFTTNSTSTLTVTVTLPNNGQLPAGSTFQASILTIGSAVSTGIFTINNGGNTGTGQVIIPAPIAGSYTLQITCPNNASFTCTAANIAITSTSTSGPAPSKGLATTTTLAAVPNPPVAGQSVALTATVQAPTLGSTAISGTVTFYDGLTPLSGAVIVTVANNIATATTNATLSTSPNHTLTAIYSGDTVYATSTSNGIVLGTGSGTTSTAAITLKSNVTTGTAGLDVVLTASVTGLTTAGASPTGTVTFYLAGTTPTALGTATLTASGAGVAIATYSSTNFPVGNSTVYAVYNGDGNFASVTSNNITIGLTDYSVTFVSPTTLTLTQGQSGTVSLLLTDIGGYTGTVAFGCMPPVGTGITCSFNPTTLTTGGSTTTLTVTTTAPIRAANTTPGIFARNLAGTASLAALLCLLLPGRKRRRLPTVLLVLLALGITANLGCGNGVAATNGANGGTPFGTSILTINTAGSDGTNTIHHNYTYQVTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H5</accession>
    <name>E8X2H5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2155</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2155"/>
    <dbReference type="EnsemblBacteria" id="ADW69199">
        <property type="protein sequence ID" value="ADW69199"/>
        <property type="gene ID" value="AciX9_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2155"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253041_0_0_0"/>
    <dbReference type="OMA" id="FICTILM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234110" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="726"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="828"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="936"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1421" mass="147165" checksum="7E8C721DAC9DBFA9" modified="2011-04-05" version="1">MNFYPRSLAFVHSILLMSIALFCGVASSQTAASSPSRETMKRMLLRQSLHFEATADGGMSSRGMGRKVRIDGGGAVMFGERDKGAVSVVLDGANSHATPEGRDLLTVQSNYLLGNKPTQWRTGVSQFGRVQVSAVYPGVDLVYYGNGEQLEHDYLIAANADPGMIRMKFRGASPRLDGKTGELVLKQPDSSEDAIRMERPVAYQLSEGGTRQGVMASYHLGADGDAQFTLGSYDHARPLVIDPVIVYGSYFGGKYTDSIVDLKVAGDGSLFLLLTTDSTDLTMPGATAGACIGKCGPANADGGTSTAPDMYVVKFDPTFQQPLFATYLGGSGSDQAYNLALDTDGSIYVAGATQSTDFPIVNGYPGGAPAGGKTSGTLTKLSADGSMILYSTFIGYGRPSVNYAPPVMATANNGIVYVIGQSGASDLAFIWQKNSLFHIAVDFLAQLDTTKTGTDSVVYATYVGDSIDGANVVTLSSLALDSKGDVWLYGSTHDNMFPTTDASALEPQCRSTPCDATFLMEIDPTGSTIPYATYLGGVDGASNVYIYPRDIVIDPSDNVYVSGYTSQAGFPTLNGYEIAIDGNQAGYISKLSPDGKTLLYSTYVPVGVEIAVSTKGLLAFTGVAGSGFPVKNNLQTPQLSPNVYDVVFGLIDTTQSFDSSLLVSSFLGSTQGATVPERVYLSPTGPILIVGTTSATDLRIVNGYQVTRSGGTSDGFITAIDPGILTLTPSTLTFPSTSIGSTSVAMTATLYNGTAKSVELAQGKLSNSTDFAQTNNCAILSPKASCTINITFTPMSAGTLTSTYTTGDLDFPNNPLTIALTGNATGATVTLSPTALDFGMVTDGTTTTQSVTLTNDSTTALPVTGAVVAGTGFALSGNTCGASVAAGATCQFAITVAPTAPSPYAGTLTVTDGFGTQIVQLTATGAAAPAAGSDTLSPANLDFGVVPVGTVATKLVTFTNGSDATIAIYTNVNSNNAFSVTATTCFISVQPHASCTLTLQFAPTYTSTQTETFQVVDKVSNPTINVTGTTFIVSPQVTLTPNPLIFKDIPQNQQTIQLITVTNNSTFPISWQFGNVTLTGGTQGFVPDNGTLATCRDNGNGGTTVAAGGSCQYGIGFQGNIATDTSETAILTIPYTLPGSTFQYGASVTLTANVVTPAAATVTPKNIQFPATAAGSKSPAQIVTVSNSGEAPLGFTSATFTGANPTAFTQTSNCPSAIAKNASCQISVTFGPDASTNEFTASLDVKLSTGDVSVTLNGGTSPMDFVVTSPTGTQNGNSSPSWLINIAPLTASIGFNQPITFTVSSLDPSYGTPTFTPSTVTPNGSSVSTTLTLTNPQQVMMKRPPFNSRQGWPVLACFALCLPFAWKLKPIRNRKILLFLLCSLAGGLVLNGCGDDPPAIVFTVNATSGSISHTVNLTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z5</accession>
    <name>E8X2Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1066</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579452.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1066"/>
    <dbReference type="EnsemblBacteria" id="ADW68129">
        <property type="protein sequence ID" value="ADW68129"/>
        <property type="gene ID" value="AciX9_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1066"/>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016729_0_0_0"/>
    <dbReference type="OMA" id="DSVGNAW"/>
    <dbReference type="OrthoDB" id="1419511at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234123" evidence="1">
        <location>
            <begin position="25"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="640" mass="64528" checksum="4DEC088E59052566" modified="2011-04-05" version="1">MTFPLKISLLLPFCLLAAGCSVQSTPTPPTTPVPVPVPPTTSGQIDGKVLAGQQPLSDATIQLFAAGTSGYGTGAVSLLSTPVTTAQDGTFSLIGDYTCPSASSQLYVLATGGNPGLTSSTSNSASVMMAALGPCTLFGSTYTLDPNAYININEVTTVASVYALAAFINPTTLQVGTSSTNATGLTNAFLTVPNLVDISTGQARTATLAANGTVPQSTINSLGNTLDLCIKSNGTGTPCSTLFAAATSTGATAPTNTLQAVLNIATHPASQAAALYQIATTSTSFSPALTAAPNDWTLSVPYKTSNSLQTRVALDADGNVWINNTVSGAVLGRSGPYSSVFKLSNQGAFLSPAIGYFANGFNALSDLAVDPTGNVWLTDSAVSSVYKLSTSGTVLATAQTGISVPNALAIDGAGNAWIANNNGTLAALSNSAVKLPGSPFTGSTLPYPTGMAIDPSSNIWIADYSATLAFGLAAFNNAGTQLPGSPYLDTNLIQTHHIASDSAGNIWLTATQSNTLHKFTPNGVPTQPGGYTGGGLNGPASVAIDGAGNAWVANGADSKSIPHIVEFSNAGLPLSGSTGYASSPVSLIGATPADDLAIDSSGNVWTLPGGYYIIEYIGTATPVATPFSLAIKNNKLAQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z6</accession>
    <name>E8X2Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+ dependent nucleoside transporter domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1067</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579453.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1067"/>
    <dbReference type="EnsemblBacteria" id="ADW68130">
        <property type="protein sequence ID" value="ADW68130"/>
        <property type="gene ID" value="AciX9_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1067"/>
    <dbReference type="eggNOG" id="COG1972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_4_2_0"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="OrthoDB" id="437016at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="196"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="43631" checksum="B55F15EB42444B25" modified="2011-04-05" version="1">MARFTGLLGLITFLSLAYAFSTDRRAIRWRTVAWGLSLQVVFAFAVIKWNTGQVILKSVSDFITGLLAHSADGSGLVFGYLGIPSNPMAVFAFSVLPTIIFVSAFFAILYHIGLMQQIIKVVAFIMQFTMGTSGAESTNVAASIFMGQTEAPLTIRPFLAGATRSELMTIMTSGMAHVSGGIMAAYILFGINAKDLLSAVIMTAPGTILVAKMLVPETGVPATAGTVKMPPSEEHANENFIAAIARGTIDGGQLAFNVAIMLLSFVALVGLFNAIMLGISNFTWAHGHIPFPHSLNNVLGVVGAPVAWLIGIPWRDCHAIGNLLGTRTIINEFLAFNELGKLKATLDPRTFSIATFALCGFANVGSIGMQIGGIGALIPSRRNDLAQLGLRAMLAGTMANLMSASIVSMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D4</accession>
    <name>E8X3D4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3429</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3429"/>
    <dbReference type="EnsemblBacteria" id="ADW70435">
        <property type="protein sequence ID" value="ADW70435"/>
        <property type="gene ID" value="AciX9_3429"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3429"/>
    <dbReference type="HOGENOM" id="CLU_3328448_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="38" mass="4423" checksum="31975D5B200914FC" modified="2011-04-05" version="1">MRFIHESRIAFPFRATSNKRLTLTESPGSERMEAIITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J4</accession>
    <name>E8X3J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1122</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1122"/>
    <dbReference type="EnsemblBacteria" id="ADW68185">
        <property type="protein sequence ID" value="ADW68185"/>
        <property type="gene ID" value="AciX9_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1122"/>
    <dbReference type="eggNOG" id="COG3942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="YNPGEDN"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="498" mass="54821" checksum="EF065A020E3A01F7" modified="2011-04-05" version="1">MHPSYAEPMQSGRGGLYLDVPSGTHEGSILIATPEIADPDRASLLLREPSSMLEDQLRFSAEWQLALRIAASKGLSKSEFLPRFLLYVCEQLLTGSAREMTEQHLGTQVFNRPPGYNPGEDNIVRSYARMLRKRLDEFFEGEGQNEPLRLHIPRGGYVPVFHTHQAIESYVVEASAASDVEPPAQIKNRLPAPIVISPPAPANPPTLRRTLLFSLLSLLIGAAVASGGWLAAHSIDAKKQHAVAHALWLQLFSNDRNTLIVPADSGLGILENLTGHLVTLDEYTNGTYLSEIKAPPGVGLENFNDLRQQRYTSVVDLNITSTLTQLPEFNPVRAEIRYARSITTEDLKHSNAILLGSTHSNPWVSLFEGRMNFVLQYTPAINQSFVVNRQPERSEQATYNNGDGTAANKTYGLVDYLPSLDGEGHVLIIQGLNMAATQAAADTLANETMMEPILQQARRPDGSLYPFELLVQTRSIGASAPESRIVGSRIHREEQHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V6</accession>
    <name>E8X3V6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2347</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580700.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2347"/>
    <dbReference type="EnsemblBacteria" id="ADW69384">
        <property type="protein sequence ID" value="ADW69384"/>
        <property type="gene ID" value="AciX9_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2347"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_0"/>
    <dbReference type="OrthoDB" id="1488472at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="182"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="27477" checksum="53B9733C9C23390A" modified="2011-04-05" version="1">MIRALYTAASGMSAQQANLDTIANNLANSATAGFRSRRVQFEDMIYQNMITPGSPATQSTVSAGLQIGLGTRTSATEIIQAQGDFNQTQNPLDLAIQGGGFFQIQQPDGTIAYTRNGSFHLNNQGTIITTEGMSLIPSITIPSNATNVTISPYGVVSATLPGQTAAAQLGTLQLANFANPGGLNSAGNSLFTQTTSSGNPVTDTPGGTSGVGTLEQGYLENSNVDVVTEFVQMILAQRAYESNSKVVHVADDMYQQINGMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X427</accession>
    <name>E8X427_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581846.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3530"/>
    <dbReference type="EnsemblBacteria" id="ADW70535">
        <property type="protein sequence ID" value="ADW70535"/>
        <property type="gene ID" value="AciX9_3530"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3530"/>
    <dbReference type="eggNOG" id="ENOG50344A8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2382089_0_0_0"/>
    <dbReference type="OrthoDB" id="2165667at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10683" checksum="BDCCFBCF2DC698AC" modified="2011-04-05" version="1">MAVPSEVKRVETAIANRNVKELEWSLWYCRMRVSIPSARPADVKYWRAVEEKVQETLAPPAEEKQYASKRKKKANRGLGMGPLPGETVVEDPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X483</accession>
    <name>E8X483_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578472.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0052"/>
    <dbReference type="EnsemblBacteria" id="ADW67143">
        <property type="protein sequence ID" value="ADW67143"/>
        <property type="gene ID" value="AciX9_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0052"/>
    <dbReference type="eggNOG" id="COG3823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060272_2_2_0"/>
    <dbReference type="OMA" id="FVTGKNW"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234358" evidence="1">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="28745" checksum="DA666AD11C31E5B6" modified="2011-04-05" version="1">MFARCFSLALVMFLSTLSAGCQSAPVQSYKVVRTYPHSTASYTEGFFYLNGLFYEGTGLTGHSQLLVVKPETGKPVQQLDLPPELFGEGIVDWGPNLYEWTWKSHTCFVYDRATLHKIGQLSYDGEGWGMTRDEHNLITSDGSTRLSFRDPASFKVVRQIAVKDGAEAVSQLNELEYIHGEIYANVWHSDRIARISPQDGHVIAWIDLTGLLPADQRVDAESVLNGIAYDAQHDRLFVTGKQWPKIFEIKALPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S0</accession>
    <name>E8X4S0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3555</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581870.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3555"/>
    <dbReference type="EnsemblBacteria" id="ADW70559">
        <property type="protein sequence ID" value="ADW70559"/>
        <property type="gene ID" value="AciX9_3555"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3555"/>
    <dbReference type="HOGENOM" id="CLU_2788058_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="6919" checksum="942750E527099734" modified="2011-04-05" version="1">MALDGGLKPPSNPNGNGNGNGNGNGNGNGNGNGNGHGHGHGSLNRNRRLPSGMTNKKYKRSDKQKDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X522</accession>
    <name>E8X522_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578542.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0138"/>
    <dbReference type="EnsemblBacteria" id="ADW67214">
        <property type="protein sequence ID" value="ADW67214"/>
        <property type="gene ID" value="AciX9_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0138"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="37678" checksum="02A93AD91313E1C0" modified="2011-04-05" version="1">MEIRRLGNSGLRVPALSFGTATFGGQGDFFKAWGATDTDGASRLIDVCLDHGVSMFDSSDGYSAGLAETILGKAIAGKRNNLLISTKVTFPTGPGLNDYGSSRQHLVEAVNASLSRLGTDHIDLLQLHGQDYNTPVDETLSTLDELVRSGKVRYIGASNFSGWHLMKSVMTSSQYGYPRHVAHQVYYSLLNRDYEWELMPLGQDQGIGAVIWSPLGWGKLTGKIRRDQPAKPGTRAHDIAGTGPKYEEERLYRIVDALLALTEQTGKTVPQIALNWLLQKRTVATVVIGARNEEQLIENIGAVGWTLSAEQIATLDAASDAPAAYPVWHQRGFPVLNEHSTTNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X526</accession>
    <name>E8X526_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0143</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578546.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0143"/>
    <dbReference type="EnsemblBacteria" id="ADW67218">
        <property type="protein sequence ID" value="ADW67218"/>
        <property type="gene ID" value="AciX9_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0143"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_1_0"/>
    <dbReference type="OMA" id="MKFLSGP"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="518" mass="58363" checksum="11BA9A864E823EB6" modified="2011-04-05" version="1">MLFNSFPFLFIFLPIALLGYQIAGRLHRRGVVVWLGIASLAFYAYWHPTFLIILGISILLNYLIACLIVRRIPNSIGTHIWLALAICANLGALCYFKYLFPFLIFVTSFTHTNHDWGRVLLPLGISFFTFTQIAYLVDLQQNAAELQDFSSYMLFVTFFPHLIAGPILHHKSIMPQFAEGRDYRLNADDVAVGFSWFIMGLFKKVMLADNFISAVDPAFAAPGGVSRLAGLIAILSYALQLYFDFSGYSDMALGLARMFSIQFPLNFASPYKASNIIDFWNRWHMTLTQYITSYVFTPVQKLIREHRQKQGLAVNRKALNTVSGFANMIAIPTLFTMGIAGIWHGAGSRFIIYGLLHGGYITSAHAWRITRTKRPNLIPKWIGQQFRHIFSVGLTFFAVIVSQVFFRSSSTGNALLLLRNTFGFHHSQSSTAALSGFPLLSALALLVLGFIIVWLLPNTQQILINFKPSLALAESDAKPAVFTFRWSPTFLWAVMLSAALVISVSHFQDPSTFLYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X539</accession>
    <name>E8X539_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0157</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578559.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0157"/>
    <dbReference type="EnsemblBacteria" id="ADW67231">
        <property type="protein sequence ID" value="ADW67231"/>
        <property type="gene ID" value="AciX9_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0157"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_10_0_0"/>
    <dbReference type="OMA" id="YWRAIDT"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="28714" checksum="4AE612B50345A828" modified="2011-04-05" version="1">MKAVILAGGLGTRIAEETGVRPKPMVEIGGRPILWHILKLYSQHGIDDFIICCGYKGYMIKEYFANYFLHTSDVTFDMRDNSMKVHNSVAEPWRVTLVDTGDSSGTGGRLRRVAPYLTPGETFCMTYGDGVADVDITASIAFHKQHGKTVTLTSVQPKARFGALGLKDTQIYSFQEKPTDEGGWINGGFFVLEPDALQAVHHDAQMFEREPIESLVAQGEVHAFFHHGFWQAMDTLRDKQQLEDLWSTGKAPWKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X558</accession>
    <name>E8X558_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1260"/>
    <dbReference type="EnsemblBacteria" id="ADW68322">
        <property type="protein sequence ID" value="ADW68322"/>
        <property type="gene ID" value="AciX9_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1260"/>
    <dbReference type="eggNOG" id="ENOG5033NR0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710695_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233690" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="17110" checksum="E870EB3D5300E214" modified="2011-04-05" version="1">MFLRMIVSLFLLVGVSTLHAQDDLDAKRKLASAGQALGKALATHDQAALEKLWSPQMIVNGPNDTVLTRAEIFQALKDGQVDYESGYKSTLEKVQFFGNIAVTMGEDTYTPAFGPDKGKLLHRRSTNVWQYKDGDWMMIARQATIYDPAVKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X575</accession>
    <name>E8X575_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1277</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579662.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1277"/>
    <dbReference type="EnsemblBacteria" id="ADW68339">
        <property type="protein sequence ID" value="ADW68339"/>
        <property type="gene ID" value="AciX9_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1277"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112762_0_3_0"/>
    <dbReference type="OMA" id="FMKIDGA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="16234" checksum="B59D6C525187D3CC" modified="2011-04-05" version="1">MAVDFYLELNGITGESEVAAFKGQIQVQSYSFGGTNVSSVGTNGGSGAGKVNLGPLTITKHADSASGPLFLDMCKGTHIPKGMLSLVKSGGGSTAYITLEMTEVFVAGFTSSATGEVPVETVHLTYKSILYTYKAQAADGTLSTKAPAGWDVVSNKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A5</accession>
    <name>E8X5A5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1307</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579692.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1307"/>
    <dbReference type="EnsemblBacteria" id="ADW68369">
        <property type="protein sequence ID" value="ADW68369"/>
        <property type="gene ID" value="AciX9_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1307"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_0"/>
    <dbReference type="OMA" id="QKKFRCE"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="251" mass="26462" checksum="22CDDB13E098CB27" modified="2011-04-05" version="1">MAEQQAEQKKVALISGANRGIGFETARQLGQQGVSVVLGARTLQAAEYAAGILKGEGIDAYGVKLDVTDVEDRRNAAAYILKHFSKLDILINNAGIGAEGGMFNAAKPSTTSPQELEGIFATNVFAVVYLTNELLPLIRKSDAGRIVNLSSILGSLTLHADPKSPIAGIKLLAYDASKSALNAYTIHLAAELKDTPIKVNSAHPGWVKTEMGTDAAPMEIVDGAKTSVTLALLGPDGPTGRFIHMGDELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K4</accession>
    <name>E8X5K4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3628</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581942.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70631">
        <property type="protein sequence ID" value="ADW70631"/>
        <property type="gene ID" value="AciX9_3628"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3628"/>
    <dbReference type="eggNOG" id="ENOG5032XR0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074114_0_0_0"/>
    <dbReference type="OMA" id="GLPWKTH"/>
    <dbReference type="OrthoDB" id="1712833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="259" mass="28769" checksum="A261BD85BDEC879F" modified="2011-04-05" version="1">MQLTGLDLFFWAAGLAGHILLLGVLLIRHRATLFPLFTTLIAANIIRTVVLYFTLRHGTRHGYFLTYWTLAIVDVVLQLLVIYEVAWHIFRPLGEWAPGIRRNLLWVTLASVAVGGALTFLATPATKTLRQAVVIRGNFFSSALMCELFVGLIVLAVTFGLPWKTHVARIAQGLGVYSIAGIVTDSATTVLGVANNSDAYRMLSHVRIALYLVCLVYWIVTLWLDAPSPRQMPEKMRRQLASLERQSAADVQAIRQGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L9</accession>
    <name>E8X5L9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3643</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581957.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3643"/>
    <dbReference type="EnsemblBacteria" id="ADW70646">
        <property type="protein sequence ID" value="ADW70646"/>
        <property type="gene ID" value="AciX9_3643"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3643"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_0"/>
    <dbReference type="OMA" id="LPWIQKR"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37367" checksum="002513CE5E12C94D" modified="2011-04-05" version="1">MIKTHGYAAQSATTAPAPFDFEHRDPRPKDVVLDIQFCGICHSDIHQARGEWGNSMFPMVPGHEIVGVVTAVGGEVTKFKVGDTAAVGCMVDSCRECASCKAGEEQYCDKRATVFTYNSKDKDGNLTFGGYANHIVVDEAYTLKVPASLDPAAAAPLLCAGITTYSPLKHWKAGPGKKIGIVGLGGLGHMGLKFSHAFGAQTVMFTTSANKIEDAKKLGADEVILTKEAGWHEAHLGTFDFILDCVSAPHDVNPYLNLLKRDGVMCSVGVPETPISINTWSVISRRSYTGSAIGGIAETQEMLDFCAEHGIVSDIEMTSFKELETAWDRVVKADVKYRFVLDLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S3</accession>
    <name>E8X5S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ImcF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4011</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572719.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70807">
        <property type="protein sequence ID" value="ADW70807"/>
        <property type="gene ID" value="AciX9_4011"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4011"/>
    <dbReference type="HOGENOM" id="CLU_273610_0_0_0"/>
    <dbReference type="OMA" id="FFGYGGT"/>
    <dbReference type="OrthoDB" id="393769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009612">
        <property type="entry name" value="IcmF-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06761">
        <property type="entry name" value="IcmF-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="3">
        <location>
            <begin position="186"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related" evidence="2">
        <location>
            <begin position="496"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121802" checksum="C3ED65999ED28224" modified="2011-04-05" version="1">MKRIWLVVLGFVLYLALVIGVGFLLHLPTQRTVLFIVILGLLGAAACAVIIWYLNKISPAGEPANAADQSNLDSLIKDADNKLKQANRPGIKSLAQLPLIYVIGDENSAKTQTILQSGLDPELLAGQVYRDQSIVPTQSINIWLTGSAAVVEASGALLRQPGLWQRLVKLTAPGKVSAALSKSALQPTRAVVLCVSIERILAPSTSEQIRALAQSMNERLRQISQSLGISLPVYVLFTKLDTVTAFAEYAANLTEAEVTTPLGSMLAETGAAGAGLYADRAAQQIGQRFDEVAYLLSEFRLELLARGGQPQTLARSYEFPRDLRKIRPGIVDFLVEVARPTQIGVNPYLRGFFFSGMRAHIVEDVLSVGAQHSAPIVDPNAGATKIFSIAAMQQQAAPTPVRSSSTRKVAQWVFLPYFFSRLVLTDKTALESSRSSTRVSGVKRFLAACVCALFAVYLVLLTISFFNNRSLENRAAAATRDIHPVGKSDVASVADLQSLEELRQVLVELDGYHKDGAPLMDRWGIYRGEDIHIAACHAWGDRFNKLLLTQTQNNITTKLAALPVKALPTDEYQATYKPLKAWLITTSNPDKSTTDFLPPVLFSEWVAARSVTAETGALAENQFEYYAGVLPEPNSCLARLGGKPDQTLIANTRGYLNSFAGMDHVYLSMKAAADRKFQPIEFKKLYPGSVRIVSAPTIVDGSFSKDGFTFMQDAINHPDQYLSGEEWVTGPVTAPIDRGHLRDQLSERYQTDFLGAWRTFIKTSQVNGFGGLEDAANRLHELDGPASPVLQVLGLVSRNTSVSIPAFSQPFQMPQAIVKTDTAPTNSGYTEKLTAIEQALRQMISAPGTPDPSGVNSAAGTAETAVNGMRGSFDPAGVVDTSAERLLREPITYVGGIAGKAGGKAANKEGGDFCAAAKTVLDKFPFNPDAKLDATPEEVATFFSPTGPIGVFVASQSKFIAYNGTLYSAVPGTQVNPALLNFLNATKSVAAILLPNGATTPSLNFSITQEATPSLTAATLDVDGTSYSTVGTSSHITWQYRVQGSVKLAGSGQTKNSFGPWSIFHFAYAAKHPAPNKLEYIFQNNGITEKSQTGVDIIYNFDLDENGAKLLNPDYMRHSMHCVSTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S4</accession>
    <name>E8X5S4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572720.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70808">
        <property type="protein sequence ID" value="ADW70808"/>
        <property type="gene ID" value="AciX9_4012"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4012"/>
    <dbReference type="HOGENOM" id="CLU_034545_4_1_0"/>
    <dbReference type="OMA" id="NNEDFHR"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27045" checksum="662729EEFDDF5B0B" modified="2011-04-05" version="1">MPNKVEVAALSDVGCVRTNNEDSFGYDPDRQVYVVCDGMGGMASGEVASQMAVSTFLQVVSDAAPATPIEAILNQAIVAANSAVHEVGLQPAHKGMGTTLVAACIEDSKLFIGNVGDSRAYLIQGHQCMQITVDHSYINELIRTGVVKVEDAGSVDLKGMQSVITRAIGVSAAVDPDFFSADLTPGDIVLLASDGLTRYIEQKELGLIIGACDLESSARNMIAVAKERGGTDNITVLLLQLVAEAQPNPLITNAELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T2</accession>
    <name>E8X5T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572728.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70816">
        <property type="protein sequence ID" value="ADW70816"/>
        <property type="gene ID" value="AciX9_4020"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4020"/>
    <dbReference type="HOGENOM" id="CLU_168228_0_0_0"/>
    <dbReference type="OMA" id="DVHEWVH"/>
    <dbReference type="OrthoDB" id="2092143at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="72" mass="7763" checksum="ABC201805FC603C7" modified="2011-04-05" version="1">MAHSATTPVAAPLSIPVIPMRELLPWALFAGLMLLMAIYFVGAEQGATALFHGTAVHEFLHDGRHLLGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X9</accession>
    <name>E8X5X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4080</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70863">
        <property type="protein sequence ID" value="ADW70863"/>
        <property type="gene ID" value="AciX9_4080"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4080"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_4_0"/>
    <dbReference type="OMA" id="MPGWHIV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="83"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="168"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="34763" checksum="7E94C78883692FF1" modified="2011-04-05" version="1">MSPSEHVESRIFRLMAEYSIDVLCRISMDLHCTYCSPSATKTLGWSTEEMLALFPLRLIHEEDKGRIRMAHQRLMDDPDCENSPATARVRAKDGSYLWFEFNARLLRDLGENAPWQVLLNMRDISERKLLEQRLEALALTDGLTGIGNRRSFDQEMQRVAAQNGYEGRRISLILLDVDHFKAFNDAYGHLVGDDCLRTLADALASSLISVGGFVARYGGEELVAIVTSADPGGDVQLAECLRHHVEQLRIPHQGNAAHGSVVTVSVGVATAVEQSGGSITDLRSGLLQAADAALYKSKGSGRNKVSSSLIILSPQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X635</accession>
    <name>E8X635_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4139</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70919">
        <property type="protein sequence ID" value="ADW70919"/>
        <property type="gene ID" value="AciX9_4139"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4139"/>
    <dbReference type="HOGENOM" id="CLU_2617046_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8546" checksum="0181867D4BE9E432" modified="2011-04-05" version="1">MRRELSAGKNEGFTPTRVRGPKVFKANDLGLDFRLQTDHAPPAKREVLGCSETARNRTPEAPAVPLFAGELQALIRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X640</accession>
    <name>E8X640_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, FliI/YscN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4144</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572836.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70924">
        <property type="protein sequence ID" value="ADW70924"/>
        <property type="gene ID" value="AciX9_4144"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4144"/>
    <dbReference type="HOGENOM" id="CLU_022398_5_1_0"/>
    <dbReference type="OMA" id="MLMMDSV"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="157"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="434" mass="46862" checksum="963A4C1D9A82340F" modified="2011-04-05" version="1">MPTPLAPYFSQLERSSSLRWSGRVLQVIGNLVESEGPSCSVGDECEIITREGRSFSGEVVGFRGSTMLTMTLQLPQGIRYGDRIIATGSRPSIRVGPELLGRVIDGTGEPLDSLGPYGSRRSMPVDAAAPLPLDRLPIRNTLGCGVRAIDAFITCGRGQRLGIFGGSGVGKSTLLGMMARGTEADLTVMALIGERGREVQEFLEVIGEEGRKKSILVVSTSDQSPLLKMRAALAATAIAEYFAAEGKNVLLVVDSLTRFAMAQREIGLAAGEPPTSKGYTPSVINTLARLVERAGNFNKGSITAFYTVLMEGDDQQDPVVDTVRSLLDGHVILDRNLALQNHYPPISVLDSLSRLMSSIAAPEHLGKARALRILLASYKRSEDLIRIGAYQKGFDTVLDRAVEVLPELNRFLQQTSEETPRFAAVAKRLNEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X665</accession>
    <name>E8X665_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4169</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572861.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70949">
        <property type="protein sequence ID" value="ADW70949"/>
        <property type="gene ID" value="AciX9_4169"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4169"/>
    <dbReference type="HOGENOM" id="CLU_039933_0_0_0"/>
    <dbReference type="OMA" id="VLEQNYE"/>
    <dbReference type="OrthoDB" id="541612at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233728" description="DUF4139 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="178"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="482" mass="53011" checksum="BCFF3ABD79E31284" modified="2011-04-05" version="1">MKHTPILAAFLIASPALAQQSAQTSLTIYNQDFAVVRSHVPLDLKEGPTEVTTTNVTRSLEPDSVVLRDPASKLSFTIAEQNYDAGVINQDSLLEKFEGKTIDFQPGPGPNGAPLPTVQGTIIRAGRNGEQPLINSGGHLQFLLPGTPLFPASTDGLLLKPTLRWQIYSPHAARLDAELAYITHGMSWQSTYNVIAPETRDVGPTERGEVVGAVTIHNNTGTEFADAHIKLMAGDVAKLQQLPVNGRAMYEMRAMAGSAPAPQVTQQAFDDFHLYDLNRSVTLRDGETKQVEFLNATDVTMSRVYEYDGAGFSPFYPGNPNYQRTFNTGSNTKVSVREEFKNSTANHLGIPMPAGRIRLYRRSAGGQLEFVGETQIGHTPTEETIKLAVGNAFDITGERHQTDFHSDTRAHTLDETYSITLKNQKPSTASVTVIEHLNRGENWKIAEQSTDSKKRDSNTIEIPLQVPAKGQTTYTYTVHYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X677</accession>
    <name>E8X677_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572873.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70961">
        <property type="protein sequence ID" value="ADW70961"/>
        <property type="gene ID" value="AciX9_4182"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4182"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="WRGVRTD"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="907"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110379" checksum="7DF15416923058BC" modified="2011-04-05" version="1">MNPSRLFIDRPIATTLLTIAVAIAGFIAFAVLPVAPLPQVDFPTITVAASLPGASPDIMASSVATPLERQFGHIAGVTEMTSSSTLGTTSVTLQFDLSRNIDGAARDVEAGINAARTYLPANLPANPTYRKVNPADSPILVLGLQSDNYDVPTLYDEASTVIEQRISQITGVGQVTVVGASLPAVRVELNPTQLASYGISLPAVQQVIAGQNSNVAKGQISNGSTTTDILANDQISKAVAYRPLVVGYHNGGAVRLQDVADVVDSQQTVRQAGFLDGKPSVNMLIFRQPGANIITTVDAVKAALPSLQASIPKGEHLITILDRTLTIRSSVNDIELTLVISVILVILVVFVFLRNVRATLIPAVAVPVSLIGTCAVMYVCGFSLDNLSLMALAIASGFVVDDAIVVMENISRHLEEGYTPVQAALKGAAEIGFTVFSISVSLIAVFIPLLLMGGIIGRLFREFAITLSAAILVSMVVSLTTTPMMCSRVLIPESEIEHGRLYKWSERGFDLILSGYRRTLNWTLDHPALILLIFLGTLALNVFLVIKVPKGFFPQQDTGAVQGGMQGPQDTSFYGMRDAVQHSVMTIKNDPGVQHVMGFTGGQGATNSGFAFIALKPLNERKASAATIINRLRPKLAKIAGAATFLQPVQDIRIGGRQANAQYQYTLEAETTAELTQYGPALLSKMKATPGFTDVSTDQQNKGLQALLTYDRPTAARLGVTPQLLDNTLYDAFGQAEVSTIYTELNQYYVVMEVAPKYWASPQGLKDVFVIPNSGGDAVPLDSVLKYAPSTSPLAVNHTGLFPSVTVSFNLAPNVSLGEATQKITELQQQLGFPQSVHGQYSGTLEAFQQSLGSEPYLILTAILAVYIVLGILYESLIHPLTILSTLPSASLGAMLALVLTNTELDVMSIIGIILLIGIVKKNAIMMIDFALNAERNEGMNTRDSIFQASLLRFRPILMTTMAALFGAVPLAVGTGIGSELRRPLGISIIGGLIVSQVLTLYTTPVIYLFMDNLRLKLAGDKSARLLTASVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E8</accession>
    <name>E8X6E8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4256</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572944.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71032">
        <property type="protein sequence ID" value="ADW71032"/>
        <property type="gene ID" value="AciX9_4256"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4256"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="GLRWDFT"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230795" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1268" mass="135393" checksum="9A049EE214648703" modified="2011-04-05" version="1">MKPSIVRLVCHTSLSAAALAVVPAALLAQSGNQGTVIITVQDPQGAVIPGTSLELVERSSNSVRKAVSDGKGLYTFINLNIGSYRLSLSHDGYQTKVYDDVLVQSSTVTPLTVSLPVGAVSETVNVTSEATAVLQTSSTEIGTVINTTDIENLPISGRSISGLTQLAAGFNGTYNGLPEGTQGTNIDGAIANNGRTKYQGTISTMISPRIESFEQVSVVTDGLSLGNGFGTATTQLNYVTRRGSNQFHGRAYYDFRNSGLNANSWANNATVNSAGVWAPVRRPKLIEHDFGGSVGGPIFRDKLFFFATFAEFRQPGNLTASNNIFANSAVQGNFTYTGTDKANHTVNVFQLAQANNPANPGTINPGVSTLIQNAIASTNGQGLAYGTDPTIIQTSFNVPGAQLQYYPVARLDYNATDKLRMYASFIMSQSNPVGSYPAPFLGAAYASQNGNNFSRSFNVNSGLDYIVNPHLINQFKFGFLYNVQQFAASAAPNWLTVPPVVFNMTGDTNNRMSGINYSLPTGYEYPVFSLSDSLSLQKGAHNYNFGFQGYREQDHYYNAPQGFPYTYFGIASGDPIVNAFGIGTALPAASSTNQSEAEQLYAVLTGRISSVSGNNGYSQSTGAYGPHSFNLDEVALATGVWFQDSWKVLPTLTLNYGLRWDFTVDPHDVKAAYHNALIDSIYGPTAQGNLFQPGTLAGNQNPGFSLNPRPFHGFDKTPQPQVALNWNPKPNDGGFLAKLLGNGATAIRASFGLRDFTEPYQFYWDASSAQGLLYNQSFSLTANTSGATGTFTPGSLAYGQALPPYAVSPTSFPSTAPLANFTFIGGGKNVEGIKANIREPYSESWSLGIQRAINRTSVLEVRYNGNRSVHDWTALNYNEVNIVENGFTTEFQNAQKNLAANGGKSFADTGLIHTPILDAAFANTPTNFTATQFINYLNNGQAGTFATQLAGNGQSTPAYFCALVGSKFAPCATNAKFTGAGAGYPINFFQANPYAAGSSTAYMTDAGYSNYNGLQVDFRQANWHGLQGDVNYTYSKTLGFGTNNNDYLATADNFYTLRNLGKSYVPQSFDLRNVGHAYGTYDLPFGKNRAFLNNSTLLNEIAGGFTLGTVVTYSSGAPFLLTGGYDTFNQNDGGVTLKGVTANDLQSAVGIHHIAGHTTALALDPKYFTGGAAGGTANTALVAPNTTAGTIGSVVWLHGPNQFTQNMALSKLIPIKERYALSLQGEFINVWNHPTWGTPSGSLQSTTFGTSSIVTGARQVELRGNITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G2</accession>
    <name>E8X6G2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4275</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572958.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71046">
        <property type="protein sequence ID" value="ADW71046"/>
        <property type="gene ID" value="AciX9_4275"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4275"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="APIWANG"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234241" description="TonB_dep_Rec domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="463"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1311" mass="138945" checksum="17AC4D5397C566DE" modified="2011-04-05" version="1">MVSFDRRPITVVSLAVALTLSLPVAAQQTLGAINGSVADSSGSLIPGVTVTAVDEATQLTRTVISNSTGAYSFVNLPIGSYTLSFQRDGFNTGRFPGIRVQADRTVTLPAQLALGSVSNSVTVEATPLLNTADTTNGYILEHAQLEAVPLSTGSFTGLAILSPGVNAELPGGTGSNSGLGNAPIWANGQRDTSNSFQLNGVDGSNLFNGKSTSQVGSSRVVNNTGEGIGGAGGVIQSASSVYLAIGNSIPTPPPEFIEEVRVNASMYDAQQGSAAGAHIDLSTRSGGNGLHGSLFGHRGTNFMNAAPFFFKKDTGVPESDKNPELHRYIAGGTLSGPIIKDKLFGFVGYQHLHVSDQETGDTEAAVPIGLSDTNRTPAGLAALTNNSFAGPIAENGISVTAGDWSSNPVGLGVFQAKNPDGSWLIPNDNGHHPSFFSPYNSFQTGTSTFIADMLAASVDWNASPKDLLALKYFYQHDPNSAPFAISNVRGFTEHMDIGSQVFSINNVQTLTSNLSVTETLGFLREKAYSTNDQPFAPGQAGTPAAAMNPAFGSTFPGLTIVDTLGSATPDGLGAQTLNIGPAASSQSSYTGVFQNRIQPSASAILTKGRHAITFGGSFSYTQLNVRDERTGKGAVATPDLATFAKNWITPYSTNGFVATTYLQGDANRYYRANQTGLYVSDKFQVLPNLTLTAGLRYDWNGGLTEKNGRIFNFDPTAYSYSDSADTISNSGIIIAGNNANGTHGISNTTLTGRQWGIAPRLGFAWQPSFADHKVVLRGGTGMYYDRGELYTYLSPGYAAGEISGGPFGISQTPPFVTEQHCAYSSSPYGNTSFLYDFYIPICGAGTPYGPDTSAYSLATPWGSTRGPGPSNPSAADITKSLPNAAAIIAGAQPFTLGAYNPANKLPYSINFTLNLQWQPRNDLLVEIGYVGNLGRHQVIPLPFNQAKIATLASPTHAAGVNKQSFSYGYTVLDPNTFPPICVNDPTEVNCQYGQMQQNYEGGNVDLRVPYTGLSSESETYTAAGISAYHALQAHLEKRLSHGIQAGVSYTYSHTTDEQSALGLFYNGNDPNNLRSGYGSADFDRKHVLNFTYSYTLPKFYGDGTLLGKLANSWSINGIAIIQSGQPYSIIDYSGAVGSLYYSTFDGITNPIVPLAPGCTAKTALTGNNGAFYNENTGTGAALKPSCFTIPLIAQGSQGVPIGDAFETGFTSGQRNIFRQTYQKRTDASLVKVLPIHDRYTLRYTFDVFNLTNTSSFDIPTDNVSQNEGYNNAPEYSTDPYSLYTKTPGGLGITKHTIGAPRQIQMALHFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I4</accession>
    <name>E8X6I4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4300</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572978.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71068">
        <property type="protein sequence ID" value="ADW71068"/>
        <property type="gene ID" value="AciX9_4300"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4300"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_27_0"/>
    <dbReference type="OMA" id="LAWWMAG"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="236"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="458" mass="50277" checksum="C7500D1D59CD1A84" modified="2011-04-05" version="1">MRQSLYAKIFLWFCATVVVTLIVTLASAAFLGAQPFGRRWMAMTQDLYAHTAVDFYLTSGDVGLQHYLDTLAHSSTIQGQLLDEAGHDVLGRTPSPEAANVLAQSNRTGQSAVRLGRVWSAASPVSGSGRHFTFVMVVHPERNPFDGTFARSMLPRIALGFLLVALCCLLLARHITRPILVLERAASDLAAGSLTVRALPQIAGRQDELARMASAFDHMAERIQTLIQTQQEMLGHISHELRSPLTRIGVSLELLRRGENESFDQMQLDLDRLNQMIGEILELTRMDLQQGVRIASEPVDLRAMLQAIAKDAAFEARERNQRIDCTIDTPCIVMGDQPLLRSCCENIVRNALLYTPPGTAIGIALRCLSNQAEISIEDEGDGVPPEALSHLFEMFYRVGILSHRHPEGTGFGLAIAKRIVVMHHGTITAAHMQPHGLAIRITLPAVSSRTASSRTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J9</accession>
    <name>E8X6J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3866</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582170.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71149">
        <property type="protein sequence ID" value="ADW71149"/>
        <property type="gene ID" value="AciX9_3866"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3866"/>
    <dbReference type="HOGENOM" id="CLU_419066_0_0_0"/>
    <dbReference type="OMA" id="YERFLIP"/>
    <dbReference type="OrthoDB" id="514419at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026950">
        <property type="entry name" value="Caps_assemb_Wzi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14052">
        <property type="entry name" value="Caps_assemb_Wzi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="596" mass="66588" checksum="49450C8356400972" modified="2011-04-05" version="1">MALIVLAGAQVAAAQTVTILPLQPSNSFLAPIRPFVGGTLGQASSAQPTHPSVDDDRNGSTFVSMDSWVYPTLERLAALGLIPSQDISIRPWTRQECRRQLRETEDILYGFGDLDTPVNDAIRNEAERLVPDLERELQEPNGKTTATLESMYVRGGTIAGAPLTDGFHFGQTWWNDYGRPLGRGTSAITGYSLRLTSGRWFFHVRQEMQSDPGVRAITPAQANLFNQLDNVPFSSAPTIPPAIVPQPAPAVAAYVRQRPLDLYAGYAFAGYAVSFGKQEIYWGPTTMGPWAFSSNAEPTYNLRLMSTRPHPFPLVPQLGSYRVDLVFGKLSGHKYPARPYYNGQKISLIFGSYFETSFTRWSVLWGVGHPMSLHTLKNNLFSSDSTGATFAYGDRTDPGDRKGDWDFRLHVPGLKEYATIYGDAYSDDEVNPIDAPRRVAWQTGLYMPHLPKAPHVDFRFEMASSEELSQDEGGARFFLNNQYRDSNTNKGFLLGNGVGRDGRAFEGRIGYWVSPRTRIEAGYRQNKISERFLPTGGTVSDGFITGDFAWNKEWSAQVFTQYERFLIPSFMPGRHDNTSARIQITWTPQKNVELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N7</accession>
    <name>E8X6N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582205.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71187">
        <property type="protein sequence ID" value="ADW71187"/>
        <property type="gene ID" value="AciX9_3911"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3911"/>
    <dbReference type="HOGENOM" id="CLU_043515_0_0_0"/>
    <dbReference type="OMA" id="WAFNGRS"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230807" evidence="1">
        <location>
            <begin position="26"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="35392" checksum="B214CDDFCCC7EA2C" modified="2011-04-05" version="1">MNTRFLTLCACAATLTSFVSSPAHAQKPFHITDRWVVGGEGGWDYLTADPASHRLYITHTNRVEVLDTTTGKSIGAVTGLTRTHGVVIMPDGKTGFVSDGGANQVVAFDTKTFAAITKIPAGTNPDGIAYEPTTNTIWAFNGRSKDATVIDVAQKKSIATIPLPGKPEFPQADGKGTVFVNIEDKNSIVRLDAKSMKATATWPLTGCDSPSGMAIDASGSRLFSVCDGNKMAVTDATTGKSLATPKIGADPDAAGYDPKSKLAFSSNGEGSLTIVDASKPGYPVLQTLTTEKGARTMSFDSGNGKVYLVTSKFAPADPANPKARPAPLSGTFTVLVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P9</accession>
    <name>E8X6P9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ordered locus">AciX9_3923</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71199">
        <property type="protein sequence ID" value="ADW71199"/>
        <property type="gene ID" value="AciX9_3923"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3923"/>
    <dbReference type="HOGENOM" id="CLU_056887_3_0_0"/>
    <dbReference type="OMA" id="RYCAGAT"/>
    <dbReference type="OrthoDB" id="948173at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Mo-bisPGD binding" evidence="3">
        <location>
            <begin position="281"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="32828" checksum="94D94D03314E54B5" modified="2011-04-05" version="1">MSNKQIPVEGFRSVASVSTYRVNAWSAEPAPDALAVEEPLEIQLTSGPSSARATKSITVTMRTPGHDHELATGFLLTEGVIEDSAQILAITTVAADAPDPNSGSALPASSPGNIVRVELEPDVIVRTATLERNFYTTSSCGICGKASLLALRSVCPPRRANTFSIDVDTLYTLPDTLHTAQHIFEATGGLHGAGLFTAQGELILTREDVGRHNAVDKLLGAQLLADAVPVRDKLLMLSGRASFELLQKAVMAGVPMVAAVGAPSSLAVQVARDFDITLIGFLRDRRFNVYHGIGHVAGLNPAPNSVQEVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q0</accession>
    <name>E8X6Q0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3924</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582218.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71200">
        <property type="protein sequence ID" value="ADW71200"/>
        <property type="gene ID" value="AciX9_3924"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3924"/>
    <dbReference type="HOGENOM" id="CLU_162613_0_0_0"/>
    <dbReference type="OMA" id="FACLDNT"/>
    <dbReference type="OrthoDB" id="2004779at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="14047" checksum="D27F6863B98A9C6C" modified="2011-04-05" version="1">MKLRMKENSIRLRLVRSELVRLQSGESIHEIVRFGLEPSQALHYALSVAAQPEPVSVAFQSSQISVTLSPDQLRSWAEESQVGIYASLAIDHTTTLEVSIEKDFACLDRSDEDNADTFANPLAGTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S3</accession>
    <name>E8X6S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-3B C17-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3947</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582241.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71223">
        <property type="protein sequence ID" value="ADW71223"/>
        <property type="gene ID" value="AciX9_3947"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3947"/>
    <dbReference type="HOGENOM" id="CLU_029920_1_0_0"/>
    <dbReference type="OMA" id="YMHMHKR"/>
    <dbReference type="OrthoDB" id="1195697at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="257"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="507" mass="54921" checksum="6062C83897A4719E" modified="2011-04-05" version="1">MTEASQPGKLYGVGLGPGDPELITLKALRVIRSAHVVAYPVARHGRSNARLIVEGELIHNQIELPMTYPLTTEESDHPGGYEAAIAEFYDATATQIATHLEAGRDVAILCEGDPFFYGSYMYLHDRLAPRFSTTVIPGIPSVMGAAAQLGTPLVRRDTELTILPGTLPEDTLAARLAAPGAYAIMKLGRNFAKVKSALHRAGVAHRALFIERATMAAERILPLDEVDPTSVPYFSLILVPDTTQPQRMETATSPGWIAVVGLGPGADHWLTPEARQTLEEATDLVGYHTYLNRVPIRSGQRRFGSDNKVEADRARHALTLAAAGHRVCVVSSGDPGIFAMASAVLEVVDQGPQEWRTLDIRILPGLSAMQAAASRVGAPLGHDFCVISLSDRLKPWEIIIKRLEAAASADFALAFYNPISQDRLWQLAAARDIVAKHRAPETPVVLARAVGRPDERITITDLAHFDPALADMQTIILIGSSTTRTITMSEGRQLIYTSRSYPGAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V8</accession>
    <name>E8X6V8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3984</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71258">
        <property type="protein sequence ID" value="ADW71258"/>
        <property type="gene ID" value="AciX9_3984"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3984"/>
    <dbReference type="HOGENOM" id="CLU_042785_0_0_0"/>
    <dbReference type="OMA" id="WAEWAMY"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230816" evidence="2">
        <location>
            <begin position="34"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="47197" checksum="C2292C7A4F2882DC" modified="2011-04-05" version="1">MHGRILLRQIALSCRRRVVSLISIKLTVAAALAATMLNPTIIAQTQAQKQSPASAPSPVDRNAAGDSPADPGPLATDLSPALTPPAIQKAMRKVADWQIAYAEPRFNQQWTYAALYDGLIAASTATGDPKYQDAVQRMSEHFDWKLIDNRFPHADDEALGRAYLELYQQHPTPERIASTREVLDHLIAHPDDPKKLLWWWCDALFMAPPVLAEMSKITNDRKYLDYMDRQWWITSAYLYDPQEKLYFRDDTYFTKKEANGQKLFWARGNGWVLAGLATVLQNMPADYPTRPKYVAQFRAMAERVIALQQPDGLWRSGLLDPAAYAQPEDSGSAFFAYGLAWGIDNGLLDRKLYLPHVTSAWQGLLQHVYADGRLGAIQPIGAAPGDVKASSSYVYGIGAFLLAGSELTKMTTRKPIHAGGNPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W0</accession>
    <name>E8X6W0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome_C554 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3986</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582278.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71260">
        <property type="protein sequence ID" value="ADW71260"/>
        <property type="gene ID" value="AciX9_3986"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3986"/>
    <dbReference type="HOGENOM" id="CLU_046129_0_0_0"/>
    <dbReference type="OMA" id="LEESKCW"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234261" description="Cytochrome_C554 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="397" mass="42957" checksum="20D54755668100A2" modified="2011-04-05" version="1">MKLLRKTGLLLYLACIFLTLWSARSAQPQQTLDLSAQTTTQERISSEVWWPTKPDMPMSAFAGSSSCKPCHQPGLAHTETSMQHAASTAAVTDFHAEKLTANSPPFKYSLTSSPSGIEFTASQGAHKLSHPLDWVMGAGDLGRTFLYQADGRWYQSRISYYTRPSALDITTGLSSTQATSLPTALGQLLSPEDARSCFGCHTVHATTSSGFNPLHAEAGLGCEACHGPTRAHVDAMHQQIHAPAHPASESAVFNPAKLSPSDSIDFCGSCHRSFADASLIIGPGQGTAVVRFQPYRLEESKCWRSTRDERLTCVACHDPHQPLERNTASYDRHCLQCHSTAAQKTQPPASTHTVSICPKASSGCITCHMPKVTVASMHGEFTDHFIRVVKPGASLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X708</accession>
    <name>E8X708_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetamidase/Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3831</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71117">
        <property type="protein sequence ID" value="ADW71117"/>
        <property type="gene ID" value="AciX9_3831"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3831"/>
    <dbReference type="HOGENOM" id="CLU_032013_1_1_0"/>
    <dbReference type="OMA" id="PELTWIY"/>
    <dbReference type="OrthoDB" id="228571at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230305" evidence="1">
        <location>
            <begin position="24"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="47517" checksum="AC5101E162FB05C9" modified="2011-04-05" version="1">MRMQWMAAVLMTVTGVLPCAARAAETEGKWVAEVSGVTLLEPVYARVSLERSGDTLTGMWGSETVKGTIKGSAVTIMLTGNDGEGGSLTGKIVADAGEGAGTMTGLGRRPGSAGGGRAPVPQEISWKLTRELVPPAKPREVNYEPTTFQAYYYAGNKPGIHIFPGDIVHTWAPDSGGTDKTLKRVALGGDPNIGPIYVEGALPGDTLVVHLIKIAPNRPTAQQGSRLMQYSVMPAYSLAAKYDQRFNGEYQLDNATGIATLTAPTPALKNFKVQMKPMLGCISVAPPGMEAFGGTHLGPYGGNLDYNGVVSGATMYFPVSHPGALFGFGDGHAAMGDGEVTQTGLETSMAVDFSVEVIKGYQTAQVREEDPEYIISFGVAGSLQEALKVSTAQLATWIKHDYGLTDSEVALFLGAEMKYEVTELVDPEFDVVSKVPKSALAMLVSQNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X710</accession>
    <name>E8X710_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3833</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582141.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71119">
        <property type="protein sequence ID" value="ADW71119"/>
        <property type="gene ID" value="AciX9_3833"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3833"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_0_0"/>
    <dbReference type="OMA" id="YWVNTTI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="269"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="364" mass="40636" checksum="75AC4420B49979F2" modified="2011-04-05" version="1">MNDHEVYEISTSFPFGRMDASTSATYLRALIGNSPIAIIALDAQHRYTMCNPAFERLFQYTSKELFSEDLDYLIAGPEMMEEARDLSRRVLQGDKVHTVTQRRRRDGMIVDVELYGIPLVVDGELAGVYGLYQDVTERNKAQTAFRAISDQMDNLQQEERRRIARDLHDSTSQELTVLNWNLARLNALVTDKDEALQRLVQETREIASQCSARIRSASYLLHPPLLGEGGLTRALPWLVEGFEQRSGIQVGLEMSANLGRFRDGVEIAIFRVVQESLTNVLRHSGSAVVQIALRCDEDWLLLSISDEGAEQGGPAVSHEKRMYGVGVSGMRERVEKLGGCFSIDGTKGGTTVMVTIPRNMGVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B9</accession>
    <name>E8X7B9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4402</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71353">
        <property type="protein sequence ID" value="ADW71353"/>
        <property type="gene ID" value="AciX9_4402"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4402"/>
    <dbReference type="HOGENOM" id="CLU_203343_0_0_0"/>
    <dbReference type="OMA" id="CSLVVLY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7503" checksum="237A4CDE61B465CA" modified="2011-04-05" version="1">MMNSFVSIGIGWFLGFVFGVGCSLVVLYAIYLGGYKKAIEDSMLTPPPENYIRLHLKAERALIPSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J1</accession>
    <name>E8X7J1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4479</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71425">
        <property type="protein sequence ID" value="ADW71425"/>
        <property type="gene ID" value="AciX9_4479"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4479"/>
    <dbReference type="HOGENOM" id="CLU_045102_0_0_0"/>
    <dbReference type="OMA" id="GWGIIAR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234277" evidence="1">
        <location>
            <begin position="30"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="396" mass="44358" checksum="FDB4E9BE2BE35224" modified="2011-04-05" version="1">MSRPRASLHFTLFSFITLCLSLPASVSGARRDAKAGQVISMTANYWHPVGEKADVQYVMKEGFPDGMIVLKSGDVALNDLSFRDGTLEFDMKPLAQDIPGMRFRQRDSKNGEEFYIRSFPDCRAEDDCIQYSPVISGFMLWNVYPQYQRRAPVVFNGWNHIRLVISGKRMNVFINDSVQPTLAVGELLGNTQQGGLELHGPAAFANLVVTPGKTDGLSPVPLPDSTGSDMNIVHDWLLGPLTSLRYGSTPRYAESPQDPRAWKPIRSERFGIVNLNRQFNASNEAAALSWLKTSVDSDRDQQQQVSLGWIGHAWVFVNGSLITSGKNFYYPESERRSPDGRLSLQNGSFMIPLHRGHNEIMIALYSSVHDDARSRTAYGWGFAMRYEDMRGLAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M0</accession>
    <name>E8X7M0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4513</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573173.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4513"/>
    <dbReference type="EnsemblBacteria" id="ADW71454">
        <property type="protein sequence ID" value="ADW71454"/>
        <property type="gene ID" value="AciX9_4513"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4513"/>
    <dbReference type="eggNOG" id="ENOG5033IKV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1882828_0_0_0"/>
    <dbReference type="OMA" id="HDATEGK"/>
    <dbReference type="OrthoDB" id="2230864at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14946" checksum="68D58956EECE4AEF" modified="2011-04-05" version="1">MSRPRIPQSLAEREFEARLTPSNQAKTLATRLPRAEMLAVEEAAQAAGQTCSQWLREAAVAHLKRPVRSRKAMPDPTLLTELMGLRQLTVNLFAAVAGSSISPDQVRDIVRQADHVKEGKADEILRRLHDATEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N1</accession>
    <name>E8X7N1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4524</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4524"/>
    <dbReference type="EnsemblBacteria" id="ADW71465">
        <property type="protein sequence ID" value="ADW71465"/>
        <property type="gene ID" value="AciX9_4524"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4524"/>
    <dbReference type="HOGENOM" id="CLU_2584811_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="9150" checksum="A5F481D2D16F6DCC" modified="2011-04-05" version="1">MRLNQITEYRFKGYRFEVWKNAPRGVRGRLKLYRGASPVELQQKALVVLERLIASSKVVCHESRSGMTYGVPRPQAQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R1</accession>
    <name>E8X7R1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4564</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4564"/>
    <dbReference type="EnsemblBacteria" id="ADW71495">
        <property type="protein sequence ID" value="ADW71495"/>
        <property type="gene ID" value="AciX9_4564"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4564"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_0"/>
    <dbReference type="OMA" id="KTPEIAC"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22405" checksum="2CF669909A5D8236" modified="2011-04-05" version="1">MTISMVYLCDHSVMRVIDTPLQDVKLLRPKQYPDERGWFSEVFTGKGFSALGLPEHFVQENQSYSSRGVLRGLHYQLGKQQGKLVRVLSGTIWDVAVDLRPGSPDFGQWAGFELTGDELELLWIPEGFGHGFLVTSESANVLYKTTGYYYPAGERCIRWDDPSLKIDWPLEGLGVPNISAKDATGSYMSQAELPPAYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W1</accession>
    <name>E8X7W1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4615</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71545">
        <property type="protein sequence ID" value="ADW71545"/>
        <property type="gene ID" value="AciX9_4615"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4615"/>
    <dbReference type="HOGENOM" id="CLU_070500_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043749">
        <property type="entry name" value="DUF5694"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18950">
        <property type="entry name" value="DUF5694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="32499" checksum="94F79D0EA7E56BBF" modified="2011-04-05" version="1">MKAGREYRIMLCMRSIRFALLVWLPVLVASAHGQKSQIMILGTTHFDNPNHDISNMAVDDVLTPARQQQIEKLVEAVARFKPTRIAIELPPSEQAHLDQRYAAYRSGNYALTSNERDQLGLRLAAKMGISQLDAVDYKSGPPGPDDAYDFAAYAATHGLQSRFEAFLAEGKQFAAGESTYLHTHTMFEWFQRANAQEYRLSNNRIYFEMLRFGDNKTNPGANWVGGWHARNMIILENVRRLAKPEDRVLVIFGAGHTFLLDQFAKESGYFDVVNTEKFLGYRIEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y4</accession>
    <name>E8X7Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4638</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71568">
        <property type="protein sequence ID" value="ADW71568"/>
        <property type="gene ID" value="AciX9_4638"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4638"/>
    <dbReference type="HOGENOM" id="CLU_2716766_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="72" mass="8065" checksum="5C72BE27686C2DD3" modified="2011-04-05" version="1">MGGQHRNRSRETRPANLDLPGNTLTQDTPGARGEPTWPRANQMKLENGGKLQDGSRLIDLTNVHYVAPQPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y7</accession>
    <name>E8X7Y7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4641</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71571">
        <property type="protein sequence ID" value="ADW71571"/>
        <property type="gene ID" value="AciX9_4641"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4641"/>
    <dbReference type="HOGENOM" id="CLU_176026_0_0_0"/>
    <dbReference type="OrthoDB" id="2031777at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11299" checksum="35F28883B9CFEB1A" modified="2011-04-05" version="1">MSKFTSAMNAAKDRSSVVADSIAPQIQATAPSAVRVEPLPVRRGRPAGKRSNHESVQVTAYIQAETHYATKIALLTNSRRGGPKKDFSDLVQELLSKWLEVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X800</accession>
    <name>E8X800_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4654</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71584">
        <property type="protein sequence ID" value="ADW71584"/>
        <property type="gene ID" value="AciX9_4654"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4654"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_3_0"/>
    <dbReference type="OMA" id="QRQMEGI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="8">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23941" checksum="983FF7BAAE4815EF" modified="2011-04-05" version="1">MLQAMPKVVKPNATHHPPKGQTVGYVRVSSFEQNENRQLEGLEVDRVFLDKASGKNIQRPQLEALMKFVREGDTVVCHSMDRLGRNLVDLRKTVGELTSRKIGVRFIKENLTLTGDDSPMATLLLNMMGSFAEFEVAWSRERQREGIELAKRDGVYKGRKRLLTPDRASELTRRLGLGESKAALAREFKLDRTTVYRYIGRAKAQPERAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X805</accession>
    <name>E8X805_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4659</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573308.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71589">
        <property type="protein sequence ID" value="ADW71589"/>
        <property type="gene ID" value="AciX9_4659"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4659"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OMA" id="IMPHDFR"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="122"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="35234" checksum="986C96AD1ACC77F6" modified="2011-04-05" version="1">MTQKRKPKTRSTRTILRLPDLDHSKSSVLQSLGSAASKRTYGAAIEDFITWYCSEPRLAFGRTVVLRYRYELESRRLAPATINLGLAAVRRLAYEASDNGLLNPDLAAGIRRVKGVKRLGMRLGNWLTADQGKKLLAVPASNSTRDKRDYAVLALLLGCGLRRAELTSLTLGHQQRDGHWAIVNLFGKCGHIRTVPVPSWVKVALDRWVIAASISEGAIFRRVSRTGTVWGPRISEKLVWWIVRRRAETAGIEKLAPHDLRRTCARLCHAAGGELEQIQFLLGHRSAETTERYLGSRQRLASAVNDKIGLEPDSGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV73</accession>
    <name>E8WV73_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578576.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0174"/>
    <dbReference type="EnsemblBacteria" id="ADW67248">
        <property type="protein sequence ID" value="ADW67248"/>
        <property type="gene ID" value="AciX9_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0174"/>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053419_1_1_0"/>
    <dbReference type="OMA" id="KAHDFDF"/>
    <dbReference type="OrthoDB" id="1822051at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="264" mass="28666" checksum="E16AE2857C6AC463" modified="2011-04-05" version="1">MSQTETAPRQHAYTGPALPQLPEPSHAERVRTLISLASVATLSTLSRKHPGFPFGSLMPFALDALGRPLFLISNMAMHTQNLKADPHASLFINQIASDGDALGAARVTLVGTAEPVPASDLPAAREAYLARHENSRNWVDFADFSFFRLNLIDLYYVGGFGVMGWVSASDYAQAAPDPLAASGPGIIAHMNADHVDSMILLARTHSGYEATEATMTSVDRLGFFLRLKTAEGYKGTRINFLQEVHTAQDTRKILVEMVRQAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV85</accession>
    <name>E8WV85_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TonB-dependent receptor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0186</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0186"/>
    <dbReference type="EnsemblBacteria" id="ADW67260">
        <property type="protein sequence ID" value="ADW67260"/>
        <property type="gene ID" value="AciX9_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0186"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="RNPVRPN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1110" mass="117742" checksum="7A76FED9C8A97436" modified="2011-04-05" version="1">MPAAHFVQTRHHLSRILLRPIETVLRVIVCSLLALFLAFTAKAQVVGGTIAGIVTDATGAAVPHAHVRIHNEDTGTERRIDTDATGHYSAPSVTVGTYTVTVGATSFATERKTGIGLTIGQATEVDLVLPVAGAEQEVTVADTPAVVNDSTQQVSGLVSERQVKGLPLNGRSYDQLITLNPGTVNYTAQRSGSVGTSNSSVGNMFAVSGRRPQDNLYLLNGVEYTGASLINVTPGGTSGQLLGVDAVREFNVVADTYGANYGKRQGAQISIVTVSGTNALHGSAYEFLRNSYLDSRNYFDQSRIPNFQRNNFGAALGGPIKKDKVFLFGNYEGYRQNLGITDVTLVPDNQARAGFLPNSAGVETKTAIGPGVAQLFNLWPVQNGPELLDQKGNLTGIGEAFSSPTQHIREDFGTARFDANLTANDLFFAVYTVDDSTANTPTQNPYSLINEDLREQVLSAQEQHVFSARLLNTARVGFSRASFLFLGSVPANVQALTGTFIAGKPIGAVVIAGSTASNGSSQITGAGANVGSDNAITRNLFTFDDHIFYTIGKHQIEAGGWAQRLQSNDNLAQNQYGQASFASLATFLTGTVKTFTVVPAPTELGWRAWFGAGYIEDTWRALPSLEISAGLRVETSNGFNESKGRAGIYGFTNGVINSTPTVGSAGLTNNRAKFLPEPRVGAAWKATSDGKTVVRAGFGLHHSLLDNLDYRFDQAAPFNTTLSYSGVPISAPTSGAAGLVSPSNVQTDLQTPTVLSYTLRVEQQIAPSTSLTIAYVGSHGYHQILSEDQNEPASIICQNNCPAGIANGTIYYPTVVKANAAVANTTSWVSQGASNYNALEVDLRRAFAGGFQFRANYTFAKNLDNGSAWNTSVSANTPAFVSYPNNAALDYGPAATDVRHLAAFNGTYDLPFGKGTRFLNSKGGIVDRAAGGWTLSTIATLQTGLPFSPQLGYNPTGSGDTRNPVRPNANPNFRGSLYTHGTTAQRAAQFFDPAAFTAPAYGTVGNLGRDTLTGPGFADWDLSLLKSIKFSESKRLQFRAEFFNILNHTNFLTPNEVVFSSGPTQDAKTLPTSGTLSTAQAAAPVQSPTAGVITAAATSRQIQLGLKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA5</accession>
    <name>E8WVA5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RND efflux system, outer membrane lipoprotein, NodT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578608.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0206"/>
    <dbReference type="EnsemblBacteria" id="ADW67280">
        <property type="protein sequence ID" value="ADW67280"/>
        <property type="gene ID" value="AciX9_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0206"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_3_0"/>
    <dbReference type="OMA" id="NYEQSYA"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="481" mass="51371" checksum="FDB91CBDF8C62512" modified="2011-04-05" version="1">MSNISTWTKRAYAIAAGGVLIGTLAGCNVGPKYKRPAYQAPAAFRGPDDAAIASEAKNSLGDQQWAQVFREPELQALITRALTNNYDLRIAAQHIAEQRAQVQITRAQQFPTVSVGGSGVGADFDSSSFGTGSGSGSGITSPLAIGSINVSAAWTPDFWGLYRKQTAAARAVLLAQTWAQRAVRLSLVQDVVTDYLQLRALDHQLEITRQTIKARQDSVDLTKALTDGGSSPLSDLRQAEQLLYTATSQVPQLEQQIQVEENALTLLLGENPGPVAHTDPNALTPPPQDLPTGIPSQLLERRPDIQQAEATLIAANAQIGVARAQFFPQLTISASAGTGGNSFASLVDSSSKTIYGIGSLSQPIFQGGKLRGQLNLAKETQQEDVLAYQKAITTGFHDVSNALIALNKQRAYREQQEKLVAAAQDSTRLARLRYQGGATAYLEVLTTDTALFTAQLNLVTAQQGEALTLVQLYTALGGGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB6</accession>
    <name>E8WVB6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0217"/>
    <dbReference type="EnsemblBacteria" id="ADW67291">
        <property type="protein sequence ID" value="ADW67291"/>
        <property type="gene ID" value="AciX9_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0217"/>
    <dbReference type="eggNOG" id="ENOG50335YU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980522_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229948" evidence="1">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="15702" checksum="57120C3A0A941A05" modified="2011-04-05" version="1">MNNLKGTIKMKIFRTAAMCGILSTLSILPIAANAQPILPQGIQPGSASGQAGATPNWTTEQIVTATVHDAWLLSGKNEATFFEMVAQLATLSAKNRGVTLPDSEAAGRKMGDYIKRTAKLDTDQLLYAVVDKAVVMTTKAPVHPAGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN6</accession>
    <name>E8WVN6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F0F1-ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580880.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2535"/>
    <dbReference type="EnsemblBacteria" id="ADW69565">
        <property type="protein sequence ID" value="ADW69565"/>
        <property type="gene ID" value="AciX9_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2535"/>
    <dbReference type="eggNOG" id="ENOG5032RTR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137927_3_0_0"/>
    <dbReference type="OrthoDB" id="2073672at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011744">
        <property type="entry name" value="ATPase_gene1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02230">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="12265" checksum="2D135321D6B1157C" modified="2011-04-05" version="1">MSDNEIVPPSIAPGKEDLFAGQIGAKAARKQRALRAGDQGVWFGLGMSGLIGWSVAVPTVLGAALGVWLDDRHPQKFSWTLTLLFAGLIIGCFNAWHWVAQQDASMREENTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY1</accession>
    <name>E8WVY1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">obg</name>
        <name evidence="10" type="ordered locus">AciX9_3739</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582049.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3739"/>
    <dbReference type="EnsemblBacteria" id="ADW70740">
        <property type="protein sequence ID" value="ADW70740"/>
        <property type="gene ID" value="AciX9_3739"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3739"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_0_0"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="9">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="159"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="365" mass="39372" checksum="2D83AA8D682A26FA" modified="2011-04-05" version="1">MFIDEARIRVKAGDGGNGCMAFRREKFVPRGGPSGGDGGHGGDVLMESSLSHNTLVHFRFNPEHKSQRGGHGLGSNCSGYAGEHTILKVPVGTVVYDDETGELIHDFSRVNESIVIARGGRGGRGNQHFATSTHQAPREHELGRSGEEKNFRLELRLLADAGLVGYPNVGKSTLISRVSAAKPKVANYEFTTLEPNLGVVSVGDWPHEQSFTIADLPGLIEGAHLGAGLGIQFLKHIERTSVIVHLVDVSDGSGRPDPVEDYKVITAELKSFDPALAEKPTLLVAAKIDAANPDKLKKLRAMAKRRKLPLYEISAVTGEGIEPLKFAVGELVQTHRPITVQEPLEVPKKHRAHYPPPANSAKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW29</accession>
    <name>E8WW29_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578663.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0261"/>
    <dbReference type="EnsemblBacteria" id="ADW67335">
        <property type="protein sequence ID" value="ADW67335"/>
        <property type="gene ID" value="AciX9_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0261"/>
    <dbReference type="HOGENOM" id="CLU_1893258_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="14636" checksum="91B594C03D32BB81" modified="2011-04-05" version="1">MKRLPILVAVAILLEACCFFFAARLMTAMYLKGHATWGQAMTAGSGDWIKGGLLVAAALLYWRVAKARPWLAVLSMAGMVYGVYGFLSMRGMVQSWNVFSGDLVVVGAMSFVLLIVIGVLAVLDFAVNRRTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW38</accession>
    <name>E8WW38_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0271</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67344">
        <property type="protein sequence ID" value="ADW67344"/>
        <property type="gene ID" value="AciX9_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0271"/>
    <dbReference type="HOGENOM" id="CLU_1473217_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="21260" checksum="97F97FFE83C9A27E" modified="2011-04-05" version="1">MALIRWLNGANDAGIEAYLGRPTAASRKRVMTLFRQLIECSGRLSRFDTDHPNFDFFDSPPPEITEEMARIQLSIQEFVQVPFLEIAYEDDKAILAISYALGANRALGEQLAVRDIVGLLETRRLELMRQCECHLWFFARKSDQRACSQNCRHRAYEQTDAFKAKRRLYMRDYYALKQSGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW77</accession>
    <name>E8WW77_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1401</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1401"/>
    <dbReference type="EnsemblBacteria" id="ADW68460">
        <property type="protein sequence ID" value="ADW68460"/>
        <property type="gene ID" value="AciX9_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1401"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_7_2_0"/>
    <dbReference type="OMA" id="ACADMPL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PTHR45779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230367" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="230" mass="23928" checksum="BFDD164A17B5A025" modified="2011-04-05" version="1">MKLTPALVLLSLAAPALAQTAAKPAVHHSTTATHRAATGACADMPLLDAKIPKIAGCPKTLFALRYIDTLVGTGPLAMPLKLYTVNYTGYLLNGTKFDSSVDRKDPIVFPAGVHRVITGWDTGFEGMHVGGKRRLFIPYELAYGDAGKPPTIPAKSMLVFDVELIAQADFPQQPPPQPRPATATPPPASTKPADDGAKPATIPGADPTKPTTVTPPAGSAATPPATTPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC7</accession>
    <name>E8WWC7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1457</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579830.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1457"/>
    <dbReference type="EnsemblBacteria" id="ADW68510">
        <property type="protein sequence ID" value="ADW68510"/>
        <property type="gene ID" value="AciX9_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1457"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_0"/>
    <dbReference type="OMA" id="HEDFILV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="34476" checksum="91FE1DBE5C53736C" modified="2011-04-05" version="1">MSLTVETRLQLAAITLADELNFTRAAERLKITQPALSKQIAELEGRVGFTIFKRTQKKVELTDAGQVFVRGCKDALALFEKSLRLARATHEEVLPVLTVGHSPYIDPGLVSALLSVHLPLHPDLRLRMESMFALDLAHAVVAAELDLAIITEPSDNPLLTNVLIATAPLCIAMPADHPAAHRRSVTMQDLAGIGWIIFSRRTHPKIYERVLEVGRQAGISPVELHHYLGAQEVVQLITENLGVAFVPKGVSDTMQSQEIAVRPLSEAALQVRSYLVLRADESSRLVNEFGRAFLRKVIPNGNIVDSSGQMRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG7</accession>
    <name>E8WWG7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2606</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2606"/>
    <dbReference type="EnsemblBacteria" id="ADW69631">
        <property type="protein sequence ID" value="ADW69631"/>
        <property type="gene ID" value="AciX9_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2606"/>
    <dbReference type="HOGENOM" id="CLU_3080395_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="52" mass="6228" checksum="157B637AF2F9C4CC" modified="2011-04-05" version="1">MENWIDVKTFDIEKFARSLEKDCQEGVKWERRKLEWILEEKKAQAEGKSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ8</accession>
    <name>E8WWJ8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Prephenate dehydratase</fullName>
            <shortName evidence="9">PDT</shortName>
            <ecNumber evidence="3 9">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="12" type="ordered locus">AciX9_2637</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580977.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2637"/>
    <dbReference type="EnsemblBacteria" id="ADW69662">
        <property type="protein sequence ID" value="ADW69662"/>
        <property type="gene ID" value="AciX9_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2637"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_4_2_0"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="210"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="30962" checksum="51346624CCE1470D" modified="2011-04-05" version="1">MWGEAIQGGAGSVSRVAIQGELGSNSHMAALGMQPADGGELRIVPCGLSAEVIERLASGEVDSAVLPIENSLHGSVSEHYDLLLQHEVKITAESLLKIRHNVIVAPGVKLSEIRRVISHPVALSQCRRWLRANGEISAEPFYDTAGSVKEIMAKGLRDTAGIAPELAATQYGGEVLVAGVEDHAENYTRFYRLVRAGAVGVEDAGADKMSVAFSVSHEPGTLIAALEEFRRAGMNLTRIESRPVPGRPWEYVFYVDVRFEGEGQADGVLAALGRSCEMVRELGRYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL5</accession>
    <name>E8WWL5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582068.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3760"/>
    <dbReference type="EnsemblBacteria" id="ADW70760">
        <property type="protein sequence ID" value="ADW70760"/>
        <property type="gene ID" value="AciX9_3760"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3760"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313957_0_0_0"/>
    <dbReference type="OMA" id="IAYVRRW"/>
    <dbReference type="OrthoDB" id="1976211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="19611" checksum="85B608B4BD2AF8F5" modified="2011-04-05" version="1">MITLYLICFVLGLVLTLFAAFSGAGHLHIGHLHLHPHLHAKPAAHVSAFNGFTLPAFLCWFGAAGYLLDRYSSVVSAVVLLAAVAAGLLGASILYVVLFKLLLPRERVLSPEDTRMEGTLARVSDAIRAGDGTGEILFSQTGARRAAAARSEDGAPIPRGTEVVVLRYERGIAYIRPLHELSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU6</accession>
    <name>E8WWU6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0352</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578752.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0352"/>
    <dbReference type="EnsemblBacteria" id="ADW67424">
        <property type="protein sequence ID" value="ADW67424"/>
        <property type="gene ID" value="AciX9_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0352"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_0"/>
    <dbReference type="OMA" id="LWHVKDM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233931" evidence="1">
        <location>
            <begin position="29"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="58"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="32114" checksum="9321B5BDAB5C2FD7" modified="2011-04-05" version="1">MTTRRRFLQLSAATAAATATAAMPRAFAGPGQKIPTLTYGVQLYMLRKQAATDLPGVFRAIHDAGFAQVELYPIAYREPAQHLRTLIADSGLQPSVSGHFDYLGLEAKLDYAHTLGLKYFVCPMIPKDQWETLAGFKKAADFFNKIGQGAKDRGMEFTFHNHCYEFKPLDGTTGWNVLMKETDPALVKLELDCYWLTQGGQNPMSILRDHKDRAVLLHLKDRIANSPVSFDMGTPQHFTELGKGNIDWPGILAQGYKQGIRYAFLDQDGTTIPIPESMKISADYLHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX3</accession>
    <name>E8WWX3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative two component, sigma54 specific, transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1481</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579854.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1481"/>
    <dbReference type="EnsemblBacteria" id="ADW68534">
        <property type="protein sequence ID" value="ADW68534"/>
        <property type="gene ID" value="AciX9_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1481"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="NSAPEAM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="192"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="40918" checksum="51EB971FEB3A3648" modified="2011-04-05" version="1">MGSLISQVAGSSPQGGVRARTVVLASADVDLRGRLRRSLSALRWTVLEAGGGAEAMELTDTGKPEALLIDEWLPDLEAGELMTQLRMIYPLMDVLRMDGAPTGGAATGRSPRRHELLHAIREAHEASPAPVSLPVQAPSSPEPLAAVSVASEMVYPELTEAEVKTLPLPAAAPMAAEAPAAASVRAAGIADMVGESAAMRELARMIRLVAPRSATVLIEGETGTGKEVVAKAVHRLSARAGKPFGVLNCAAIPESLLEAELFGHTRGAFTGAVQSRTGRIEAANGGTLFLDEIGEMPLALQAKMLRFLEYGELQRVGDNETMRVDVRVIAATHQPLEQRAEEKAFRLDLYYWLRLWLESATLGGPGRLPATTADMEDHLYVIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY4</accession>
    <name>E8WWY4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579865.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1492"/>
    <dbReference type="EnsemblBacteria" id="ADW68545">
        <property type="protein sequence ID" value="ADW68545"/>
        <property type="gene ID" value="AciX9_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1492"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_0"/>
    <dbReference type="OMA" id="IAGRTMF"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="466" mass="53319" checksum="F22713801C315058" modified="2011-04-05" version="1">MKGEWRMPPGLKRSLPFYAHKPWVKLGSPILLFEYLHETYGNIAHYQFMGTPIVFVNEPEYIREILVNQAGSFVKERTVKRMKILLGEGLITSEEPFHMRQRRIAAPAFHRQRINAYADQIVASAVTARERIVAGERFDIATASMGLSLEIVARTLFDTQVDDDIRRINDEVNTIMDLYNFIVAFPRIEMFLKLPIPGITRFRGAKARLDAVVDRLIEQRRKTVETEADRGDLLSMLLTSQDELLDADGKPTGEFVQMSDAQVRDEVLTIFLAGYETVANGLTWTWYLLSQNPEVEAKLHEELDRVLGVGDARRLPVLGDYAALRYTEMVFAESMRLYPPAWAMGRMSTKAVELGPYRIPPGAHFFFSQYMMSRTEEHYPDPLRFDPERFTAEAKAARAKFTYFPFGGGSRQCIGESFAWMEGVFSIATLAQCWRLRYADATPPEVQAKITLRPRDALHMVGERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB2</accession>
    <name>E8WXB2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0373</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0373"/>
    <dbReference type="EnsemblBacteria" id="ADW67445">
        <property type="protein sequence ID" value="ADW67445"/>
        <property type="gene ID" value="AciX9_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0373"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_1_0"/>
    <dbReference type="OMA" id="GLYHGVF"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="496" mass="53615" checksum="FFC398737780B892" modified="2011-04-05" version="1">MVVAIQIKNQKRAGVGACLKVLPPVFAGVFCGFAVAQQPDPALPTAPSAVVRPLQLASGVVIPQETPGAMPLTLDQAITLGLKSNAQILIQGQQERSVKGQTLSVENALLPSLTASAYTRAQEINLAAMGFKPSALAGLSIPGFNIADIQEIVKVNTTNAQLALNQQLFNAPAYFLYKAAKKASDAATWNTLNVRGGVVLAVGGYYLRTLADQAQLKNAQALVKQDQLVYDHAKAERDAGVGINLDVLRAQVQLQNEQQETIRDEAAVAKDKIALNRQMGQPAGQELDLVDTVPFAEYTGLSLEDERALAFTRRKDLLGLQSQLDVATQTARAVKYERLPTVGAGGFYGVLGETTGLYHGVFAAQGKVQFPIFEEAELRGQKEVAQAQIIGLKRNIDGLKVQIEADIRSAQLDVDTYDELVKVARSNQDLSAQELQDATDRYKAGVDDDLPVVRAQATLQGAEAQVIQAEFQYNYAKLRLSRSIGVTETQYKQFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE1</accession>
    <name>E8WXE1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0402</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578802.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0402"/>
    <dbReference type="EnsemblBacteria" id="ADW67474">
        <property type="protein sequence ID" value="ADW67474"/>
        <property type="gene ID" value="AciX9_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0402"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_0"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="34399" checksum="57D356F5E01A94F7" modified="2011-04-05" version="1">MHMVASNNRTMQRILKTSLALTAAYVITTFYFGLRAHSLALISEAGHNVSDMLAIILSFVAVYFQSRPANDHKTFGYQRAGVLAAFVNALTLIVLAAWIAISALHRLYAPVTVQPRLMMYVAVAGVLMNGLIATLLWKFSGDVNIRSVFLHMLGDTLSTAAVIAGGAAILFTGLQWIDPVLSLIIAGMIMISSYGIVRDTLNILLEGTPKNLSLPDIRTAIESVEGVNGVHDLHVWSLGSKSHALASHVLVSEMPMSDCTHILDSIQNALWDKFHISHTTIQFETRGCETTHGCSAPPELEIAGAHSHDHSHHGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG1</accession>
    <name>E8WXG1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8 9">Transaldolase</fullName>
            <ecNumber evidence="5 8 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tal</name>
        <name evidence="10" type="ordered locus">AciX9_0422</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="5 8 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578822.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0422"/>
    <dbReference type="EnsemblBacteria" id="ADW67494">
        <property type="protein sequence ID" value="ADW67494"/>
        <property type="gene ID" value="AciX9_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0422"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_0"/>
    <dbReference type="OMA" id="KFGYKTL"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="PTHR10683:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="36171" checksum="ED3B238294574EBC" modified="2011-04-05" version="1">MPSLLEQLKTMTTVVADSGDINSIKQFKPTDSTTNPSLIAAAAALPEYQSIVDDVLKTAQKELGSNADDKEVAAHAFKTLAVAFGRKILDIVPGRVSTEVDARLSFDKEKTIEQAHDIIAQYDAAGIGRERVLIKIASTWEGIKAAEQLETEGIHCNLTLLFGLHQAIACAEAKVTLISPFVGRILDWYKKDTGKDYTGSEDPGVQSVTTIYNYYKKFGYKTVVMGASFRNIGEITELAGCDLLTIAPKLLAELEASQDTLTRKLDASKSASMDIQKIPMDKETFEKMHAEDRMAHDKLKEGIEGFSKALEDLEKLLAKRLSEIKEPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ7</accession>
    <name>E8WXJ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1560</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579932.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1560"/>
    <dbReference type="EnsemblBacteria" id="ADW68613">
        <property type="protein sequence ID" value="ADW68613"/>
        <property type="gene ID" value="AciX9_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1560"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080587_0_0_0"/>
    <dbReference type="OMA" id="GTLWSGD"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25615" checksum="3FC587875D7B6B7F" modified="2011-04-05" version="1">MTATHLSTEAFESSITHIAPRTAVFDCDGTLWSGDAGSSFMVWTIETGLLSTEAVNWLNDRYQGYKAGQVSELAICGEMVQVYRGIPEATMRAAAAEFFSTRIEPNIFPELARVIANLQATGTDIWAVSSTNDWVIEEGVRRFNIPANRVLSARVAIENGIVTDKVLDVPTDQGKVDSLRRAGILTPDAVFGNSVHDAAMLAIARQAYPVNPTPALIDRSAAEGWPVYFPASVRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX6</accession>
    <name>E8WXX6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578843.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0443"/>
    <dbReference type="EnsemblBacteria" id="ADW67515">
        <property type="protein sequence ID" value="ADW67515"/>
        <property type="gene ID" value="AciX9_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0443"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_0_0"/>
    <dbReference type="OMA" id="FACRPCY"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="356" mass="39667" checksum="FBF3ACE55C828328" modified="2011-04-05" version="1">MPQPSVLILKFGAIGDVIMAIPAAHALHLQGFRIDWICSPTVAPILALYPWINPILIDDRALLKGSPLAKLKVIAKMWRTLAGRHYDLVANLYYDPRYRILTLPVRATRRLMLSTTDRRFQLLPGRHHTDEYARILLNLPDHVRPTQLAPIPAPNLPPSPHPRTPGHARVILAPAGARNLLRDDLLRRWPPELYVELTRQLLAQNIEVVLIGGPDDAWITESFASLQVTNLIGKLKLPETLALLDDSDVMVTHDTGPLHLAGITRVAIVTLFGPTDPHGRLPQRPGTLALWGGEHFACRPCYDGRDFAPCPSNDCMRQITPTAVTHQILQLLQTQPNKPSLFSSVPSVIRFPPYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ0</accession>
    <name>E8WXZ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578857.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0457"/>
    <dbReference type="EnsemblBacteria" id="ADW67529">
        <property type="protein sequence ID" value="ADW67529"/>
        <property type="gene ID" value="AciX9_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0457"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_13_2_0"/>
    <dbReference type="OMA" id="QWNEHYP"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18326" checksum="D1C86DF0BACE6260" modified="2011-04-05" version="1">MTVRLATMEDVSAVMGLVRRVVPGMRAGGNTQWDDVYPNAEVFGRDVELGQLWVAEIDGVIAGVAAITTDQEHEYAEVGWDITETAIVVHRLAVDPAFQGRGIARALMELGETVARERGIGVLRVDTSKDNAVTQRLFPKLGYRLDGEIGLSFRPGLRVLCYEKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY06</accession>
    <name>E8WY06_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0473</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578873.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0473"/>
    <dbReference type="EnsemblBacteria" id="ADW67545">
        <property type="protein sequence ID" value="ADW67545"/>
        <property type="gene ID" value="AciX9_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0473"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_4_0_0"/>
    <dbReference type="OMA" id="HIVPCNS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="129" mass="13966" checksum="582689D83A0F0B20" modified="2011-04-05" version="1">MQLQDSKHKKKSNVLVIKDGTKGNVICTNGSMANTFRTRLFGLLGRKGLAAGSGLLIEPSSGVHTFGMSFPIDIVSLDRNQRVVGLSHNTPAWKIRGLGLKTRSVLELPAGRIQECEIEHGDQIVVEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY49</accession>
    <name>E8WY49_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="3" type="ordered locus">AciX9_1624</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1624"/>
    <dbReference type="EnsemblBacteria" id="ADW68676">
        <property type="protein sequence ID" value="ADW68676"/>
        <property type="gene ID" value="AciX9_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1624"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605151_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="50090" checksum="A43A5560A30DC0B2" modified="2011-04-05" version="1">MARGRMADAVRTWNWSATPLGRIEQWPEPLLAHVNLALSFPIPAVVHWGPEMHMVFNDAYAELLGPEGHTYLGQSAPIVWKPLWPQIESLYSSVRRTGESISGNDLLIPVDRDGTLRDVFWSYAIAPIHHQQTVAGIFNTARDTTATVASFNALVQSDERLRLALSASDCIGIWDWHIPSDIIHAEQDFALFYGQDPQRARLGIPRTEYFEKVHPDDRVPLDDALWYAIQNFTEVLADYRLLPPDGSVRWVQAKGRCFYAEDGSPTRFSGISIDITRRKIAEAALAETRMTAAAQPPKVALAPKIEAPLASIATILRLARSTDDLTEVQRFLVVAEREVNRIADLACPPAESTSDAPQSAPAPILPPATPTLLWHMEILVSTIARSLAERKDDVRVSIMRRAEGITFLLQVAADDLARVLGPQGRTAQSMRSLLDAAGIRSNQQFSLDIEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA9</accession>
    <name>E8WYA9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1687</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580055.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1687"/>
    <dbReference type="EnsemblBacteria" id="ADW68736">
        <property type="protein sequence ID" value="ADW68736"/>
        <property type="gene ID" value="AciX9_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1687"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051308_0_0_0"/>
    <dbReference type="OMA" id="DDTRGLA"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="43650" checksum="8B8894CC7BB7920C" modified="2011-04-05" version="1">MTGSGTALAQHRIARLASQRLVHRAFHWLHLHQPQLRMWQMAMLAIPAPPFGEEARALWFLERFRELGLGNVHLDEEGNALGELGGGERRPTLSDEAAEGGAHGSFILVSAHLDTVFPAGTDTTPTEDGARILGPGSCDNAAGLSGMLGLIAALKFAGIEPEVPILFAANVGEEGEGDLRGMHHLFERGEYSGRIRAAVALEGSGTATAVDRGLGSRRFRVTVTGPGGHSWTDAGAPNPILLLARGLVELADRVSGAGAEARTTLSAGQIGGGTSINSIPETASVLLDLRSTDPFELQRHELEIHRTFELIVGRSGGGAKLAIEVIGSRPAAALAADAGILQTLKAVDRHLGLRTEMRLGSTDANVPLAMGIPALAMAAGGTGGGIHTLAEWYDPTGRETALRRLLLVILDLVGVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE0</accession>
    <name>E8WYE0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2823</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2823"/>
    <dbReference type="EnsemblBacteria" id="ADW69846">
        <property type="protein sequence ID" value="ADW69846"/>
        <property type="gene ID" value="AciX9_2823"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2823"/>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038349_0_0_0"/>
    <dbReference type="OMA" id="KPVMAHE"/>
    <dbReference type="OrthoDB" id="746668at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="568" mass="61513" checksum="4BEC5A4963A2166C" modified="2011-04-05" version="1">MSGGKTTASARATTGILRFAQNDCLKQTTATANTEVLSFAQNDDLEQATATAATEVLRFAQNDPSSGTSGLGWGSRVFLLGLMVGCAVGAGAQAAAPDKLMTKEQTRELFDSVDSVMGFVSKDSGLAPVEHVKRRLLARAEVTRYLEKNFDEDESSKRLQRSEIVLKKFGLLSRDFSLRPFLLSLLTEQVAGFYDSRTKVVNLLNWVDPEDQKPVLAHELTHACQDQKVGLEKWSSNGLKGISKTASEDNSRVQVDELETARQAVTEGQAMVVFVDYSLKDTGRTLKDAPDVGQKIRESASDASSSPMLARAPLLLQRSLLFPYGDGLGFEQAVLVKKGKDAAFAGVLADPPSSTFQIMNPDAYMAHVPVPVLRMPDVHAVLDAEYEPYDVGVMGELDVEMLVTLFGGRELGTALAAEWDGGVYYAGQRKSASVADKASTGSVGLVYFSRWKSEEAAQTFLRVYGEQLPRKYSGLKERNADEQVDEQVFSTSEGDVVLSVSGETVFVSEGIGLAAARKLHSGFLEVQGRGPMKMAMQPTRELTYGLVKGMAGFGVMKAGLMERYTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE6</accession>
    <name>E8WYE6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2829</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581167.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2829"/>
    <dbReference type="MEROPS" id="S41.008"/>
    <dbReference type="EnsemblBacteria" id="ADW69852">
        <property type="protein sequence ID" value="ADW69852"/>
        <property type="gene ID" value="AciX9_2829"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2829"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_1_0"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230459" evidence="2">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="43748" checksum="D1D2C18BAF91AD91" modified="2011-04-05" version="1">MPKSSKILLLAVSVVFVLTVFFGVHASGVSAASEPQEGAYRQINVYSEVLRHIQSDYVSEPNIPQVTNGALRGLLESLDADSSYLAPADYAAYKKAIAVDKGARAQVGMVISKRFGYATVVSVVPGSPADKANFNDGDIIEAISGVDTRDLSLAMLGTMLEGKPGSELTVSVVRPRKTVPDKVTMTRTITIEPPVAETMYENSTIVYLKPVILDHDHVAALEGKLKASQKNGGKKVLLDLRDVSAGDMADATLLANFFLKSGTIATLEGQKVAKVTFTADGAKAIDPTGAVVVLVNRGTAGPGELVAGALLDNKRAELVGEKTFGEGAQQKTFELPDGAALILSVAKYETPSGKKLQDDAVTPGVLVAGNTPNDDGESDDDTVAVEGAASAATVPVVKPTVTVDDQLTKALDLLKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ0</accession>
    <name>E8WYJ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0516"/>
    <dbReference type="EnsemblBacteria" id="ADW67588">
        <property type="protein sequence ID" value="ADW67588"/>
        <property type="gene ID" value="AciX9_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0516"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043515_0_0_0"/>
    <dbReference type="OMA" id="VAGEANH"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230071" evidence="1">
        <location>
            <begin position="29"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="36866" checksum="938ACC52ABC1DB91" modified="2011-04-05" version="1">MTKSAFHLPGLWLSAICVLAAGFGTAYAQAQKPFGIQQRWVIGGTGSWDYVKVDSASHRLYVAHQTKVEVIDLTSGKLIGSIGNLKRCHGIAILPDGKTGFITDGNANQVVVFDTEKLTTIETIPAGKKPDGIVYEASTNTVWVFNGNSKSVTVLDAVSRKPVATIALPGKPEFPQTDNEGTVFVNIDEPNSIVVLDARTKTLTATWPLRGCKGPSGLAYDQDGKRLFSVCDGRKMAVTDARTGKPLGLAQVGDGPDAAGYDARNDLAFASNEDGTMTVIDAGKPEFPAIQTLATMKGARTMGVDATTGTIYMVSAKLTSHIPPPTPEVTHPRPDPVPGTFTVLVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK6</accession>
    <name>E8WYK6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prevent-host-death family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578932.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0532"/>
    <dbReference type="EnsemblBacteria" id="ADW67604">
        <property type="protein sequence ID" value="ADW67604"/>
        <property type="gene ID" value="AciX9_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0532"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2601147_0_0_0"/>
    <dbReference type="OMA" id="IWESEEQ"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8680" checksum="891143AF360BED07" modified="2011-04-05" version="1">MRQVQLHEEEEQFASLVSEAEAGESLTILRAGKPVAQIIPFPEPAADDDGVAAMRRLQALMKQGLDLGGVWNGRDELYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM2</accession>
    <name>E8WYM2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0548</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578948.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0548"/>
    <dbReference type="EnsemblBacteria" id="ADW67620">
        <property type="protein sequence ID" value="ADW67620"/>
        <property type="gene ID" value="AciX9_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0548"/>
    <dbReference type="eggNOG" id="ENOG50349BR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135683_0_0_0"/>
    <dbReference type="OMA" id="QVQASPM"/>
    <dbReference type="OrthoDB" id="2173192at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16681" checksum="1C3AFFBC6E941B84" modified="2011-04-05" version="1">MQTPSNLTIWLSEQAGPLALIALLLGFVMVVLYLSARSRRVRMNEQRSGTNEDTFVNFLTAYGFDPNIARSTYRYLQDKQRVSFPIEAGDLLDEDLGLDNVDVTESVHDLLSLNYRLHQPGINHSPLVTVEDLVRFIQASPRLSEMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ4</accession>
    <name>E8WYQ4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1691</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580059.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1691"/>
    <dbReference type="EnsemblBacteria" id="ADW68740">
        <property type="protein sequence ID" value="ADW68740"/>
        <property type="gene ID" value="AciX9_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1691"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_0"/>
    <dbReference type="OMA" id="EHMCQGF"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="596"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="804" mass="90117" checksum="8ECADDD852C3DB8D" modified="2011-04-05" version="1">MTTTGASAELSVSPATAEELRKMDAYWRACNYLCVGMLYLLENPLLREPLKAEHIKNRLLGHWGSDPGQTFTWVHLNRLIKKYDLDMIYIAGPGHGAPATLSNSYLEGVYSEVYPEKSEDVAGLQRFFKQFSFPGGIGSHCTPETPGSIHEGGELGYSLSHGFGAAFDNPDLIVTVVVGDGEAETGPLATSWHANKFLNPKTDGAVLPILHLNGYKIANPTILARISPEELESLFRGYGWTPYVVEGDDPAKMHVLMAEVLEKCVTEIRDIQAKARAEGATVVRPRWPMIILRTPKGWTCPKELDGHKLEGSWRAHQMPIMDPKTNPDHLKLVESWMRSYKPEELFDESGKLIPELREMAPSGTRRISGNPHANGGELRKPLDLPRFQDYGLKVEEPGQTEVSSTDTLGHFLRDVVRKNMTSFRVFGPDETASNKLDAIYEASGKRWLAEMEASDADGGNLSIDGRVMEMLSEHTLEGWFEGYVLTGRHGFFSSYEAFVHIIDSMFNQHAKWLEKSKLELRWRAPISSINLLITSLVWRQDHNGFTHQDPGFLDVVTNKSPEVTRIYLPPDANCLLSVADHCLRSVDYINVIVADKAPHLQYLNMDEAVKHCTKGIGIWDFASSDAGADPDVILACAGDIPTSEALAAVAILRERCPELKIRFINVVDLFRLMPEHAHPHGLSDQEFDGLFTTDKPVIFNFHAYPSLIHKLTYKRKNHANFHVRGYKEKGNINTPLELAILNQVDRFNLAIDVIDRVPGLMTTAAHTREWLKDEITDSVNYAHENGIDRPEIRNWKWPAGSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ05</accession>
    <name>E8WZ05_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8 and S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2897</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581235.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2897"/>
    <dbReference type="EnsemblBacteria" id="ADW69920">
        <property type="protein sequence ID" value="ADW69920"/>
        <property type="gene ID" value="AciX9_2897"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2897"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_5_0"/>
    <dbReference type="OMA" id="INANAVW"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230472" evidence="4">
        <location>
            <begin position="27"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="158"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="638" mass="66110" checksum="FE0C7FD33ECCDA4B" modified="2011-04-05" version="1">MTRLPKFFTSLIPLAGLFSVPALALAQNPKLSSDLQALLAPAPTPSAAVSRLAVPAAAAVSAKPSSMPLIIQYKASPTATDTALISTLLGTDVTQLTSINALAATLPLSSLTTLTSQANVTYITPNRPLGARQSGTSVAQYTTEPINANAVWAQGYNGTGIGVAVIDSGINSQVDDLAGNGFILNLFSRVVWSQSFVPTAPYDANDYYGHGTHVAGLIAGNGSDSTGKKYYRTFSGVAPNSYLINLRVLDENGQGSDTSVINAIQTAIKLKNLLNIKVINLSLGRPIYESYKLDPLCQAVEQAYRAGITVVVAAGNDGRDLALNSEGYGTIEAPGNDPYVLTVGAVNTNGSASIQDDVMASYSSKGPTFIDHFSKPDLIAPGNLVSSLKFSNDPLAVNNPTFVTLNSSYITNGNSKSSKDYFPLSGTSMATGVTSGAVALLLDAQPNMTPDQVKAFMMRNANRTYMPVTSKVTDPTTGTTYTAHNDALTIGAGYLDIQATLADVKANLKRIPTGNAMSPVATYNPDTNTVTLVTDQTALWGATALWGASNVYGASAFAAPVGGQTALWGATALWGANDPAAFTALWGATALWGASSPAAQTALWGATTDESNGSTALWGASTVNGSTALWGATAPYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ25</accession>
    <name>E8WZ25_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="11" type="ordered locus">AciX9_2917</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581255.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2917"/>
    <dbReference type="EnsemblBacteria" id="ADW69940">
        <property type="protein sequence ID" value="ADW69940"/>
        <property type="gene ID" value="AciX9_2917"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2917"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_6_0"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="534" mass="59163" checksum="FD91DBA32F466D7A" modified="2011-04-05" version="1">MASVLYQSIEALSREKGIEPAVVVSAIEDAIALATRKYYKTQENMRAEMDKDTGEIRAYVFKTVVETPEEIVDEINQLALEPARALAPEVEVGGELRFYKDTTPLGRIAAQMAKQVIFQKVREAERDTVFNEYNHRAGEVLNATVKRLEPMDVIFDLGKAEARMPKREQSRLEQFAVGERVRVVLLRVDRAAKGPQVIVSRAAPALVQNLFQSEVPEIYDGTVSIRAIAREAGERTKIAVMSRDKDVDPVGACVGMKGMRVQSIIRELRGEKIDIIEYSEEITTFAEKALQPAKVSRVSITDLAEKQIEVIVDDTQLSLAIGKKGQNVRLAAKLLQWKIDIKSEEEKRQEVEQQMQAMSGGPTTPIEQVTELGEQILEKLIAAGITTVEAVADMTAEELEQIPGIGEKTIEKISVAVRHYFGQYEEGEERPVPMAVIETPTDTEETTSMSKTPEEILAAERGTDPNAEVPVELDDISTEDIAAAEDEESESDAFSDNDAREEGIELDNDTIDTLVDESQEVSDEGIDTDGHDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ65</accession>
    <name>E8WZ65_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0596</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578995.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0596"/>
    <dbReference type="EnsemblBacteria" id="ADW67667">
        <property type="protein sequence ID" value="ADW67667"/>
        <property type="gene ID" value="AciX9_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0596"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="MSHPGQL"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26887" checksum="99BAF2ADD9E21D7C" modified="2011-04-05" version="1">MNTILVVEDDVRIQKALQRQFSSEGYAVRVVSEGTEAARVCREIKPVAVVLDLMLPGISGRDICRQIKTDSVDTPVIILSAISEVADKVLLLEIGADDYVTKPFSPRELLARVQAAIRRAARTVEAQASAHAAGGAAADAEPALCVFGSVTADLLKMEVKREGVEVTLTAHEFKLLRYFLTHVDRVITREELLQDVWGYNFFPTTRIVDNQVLKLRQKLEADPAHPVHFRTVHGIGYKFVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ76</accession>
    <name>E8WZ76_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2235 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0607</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579006.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0607"/>
    <dbReference type="EnsemblBacteria" id="ADW67678">
        <property type="protein sequence ID" value="ADW67678"/>
        <property type="gene ID" value="AciX9_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0607"/>
    <dbReference type="eggNOG" id="COG3673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_6_1_0"/>
    <dbReference type="OrthoDB" id="348728at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="DUF2235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="DUF2235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2235" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="37131" checksum="160DAD3C9AF601C5" modified="2011-04-05" version="1">MSKNIIFCADGTWQLPRNNTNVYKISKGLTTSATQVVFYDDGIGSEATGFTRALDGALGIGIFDKIKTGYTMISQVYERGDQIFLFGFSRGAYTARSLAGMIATCGLPTGGFDDALVEGAFAAYRDPVNRPTLLANLAKYALEDTCITMVGVWDTVGALGIPAIFGGVDKQYGFLDTGLHKDVKNAYQCMSIDEQRCEFPITRWTSDPAPGQTIEQIWFSGCHGDVGGGTPAGGGVDETTTLSDIPLSWIVGKAVKLGLIFDPTFLAQYTSVPIKFSLDALHESWTPVFGKPVSRPIGNSDSIANSVTARIEYALTYQPKNLTIKDNVLDDGYNLIEIVDEDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ82</accession>
    <name>E8WZ82_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
            <ecNumber evidence="7">3.2.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0613</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579012.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0613"/>
    <dbReference type="EnsemblBacteria" id="ADW67684">
        <property type="protein sequence ID" value="ADW67684"/>
        <property type="gene ID" value="AciX9_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0613"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_6_1_0"/>
    <dbReference type="OMA" id="WESTDKH"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fucosidase_C" evidence="6">
        <location>
            <begin position="440"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="522" mass="58196" checksum="A37FD03C5840514D" modified="2011-04-05" version="1">MPLTRRHFLGQAASAALLASARAQTGAPAGQPGAYAKPKPMIPGPYQPTWESLRDLYRVPTWLNEAKFGIFIHWGLYSIPAHINEWYIKHMYTTDSAWHTQHYGPPDKFGYKDFIPLFKVPNYRPNEWASLFKNSGARYVIPVAEHHDGFAMWDSDLTPWSAGKMGPKRDLIGELAKAVRDQNLIFGLSNHRMEHHDFAYPAPGVPNDQFDPRYAGFYGPPIQGDMNQGNASQAFQEDWLARVQEQIDKYHPQMIYFDNGVNPRDYDDVKLRAAAYYYNRAHEWGQQATLATKDVAYLFGSVQDFEKQQRAPRWIYPAAGWQVDDSIGSTWGYTDGMSIRPAESIIRELVEIASQGGNLLLNISPMGDGSIPEAQQQALLGVGNWLQTHGEAIYGSRPWVHMGEGPTIPTEVPGDWKGGSTAVPGPPLKRPTPIPVTEADLRFTINKGCLYAFGYKWPTTNKAILTLLATGKAKVERVTLLGSATPIPFHQTPEALNVTLPNQTTPGMYALKIEGTFLLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ84</accession>
    <name>E8WZ84_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0615"/>
    <dbReference type="EnsemblBacteria" id="ADW67686">
        <property type="protein sequence ID" value="ADW67686"/>
        <property type="gene ID" value="AciX9_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0615"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042785_0_0_0"/>
    <dbReference type="OMA" id="RPSNIWT"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234003" evidence="1">
        <location>
            <begin position="25"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="45953" checksum="29F454239027D75E" modified="2011-04-05" version="1">MMQNRYVRSFVFLGFSALSSQLIAQQAAYPQPSAAMQAGIDKDGSRHFGSAPAEAVAGPLARDLSPAITPKAVDAAIKKVADWQLKEAEPYFDRIWTWSVLYSGFMAASDATGDAKYRDAMTAMSTKYKWELRNRIPNADDQSVGQTYLELYLAGGKNDAGMITPMQGDLASVIGLDTLKPGDPRIPWWWCDALFMAPPAWARMYAATGDAKYITYLDAQWQRTSALLYDKDEHLYARDASYIPKREENGKKIFWSRGEGWVMGGLVRTMEFLPKDDPRRAFYLQQLREMATRVAGLQGKDGLWHAGMLDPEHYPLPEISGSALFVYSMAWGVNEGVLDAKVYRPVIERAWKGILQHVYADGRLGCIQQTGAEPAFYLPTASYNYGVGAYLLAGSELKRMSLHKPLQRTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB3</accession>
    <name>E8WZB3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0644</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579043.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67715">
        <property type="protein sequence ID" value="ADW67715"/>
        <property type="gene ID" value="AciX9_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0644"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079303_0_1_0"/>
    <dbReference type="OMA" id="WMRHTAF"/>
    <dbReference type="OrthoDB" id="1725002at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="24725" checksum="E488075E7AF973A5" modified="2011-04-05" version="1">MPTHPASETTEHVPAAALLAITGGILDAVTYIAYGHVFANAMSGNLVFLGLEAAAGNWSQALHHIIPLCFFLIGVVAALRLRDSKLPHARLIALLVEIVTLGILGALPASFPNLILLATVSFVSAFQVTTFRHVGPFNYNSTFVTGNLREVAGGLYEAFRSPDPAIRYHSRSRARHLALICACFLLGAILGALAAVHHPTHSLWAAEPPLLTVLAILLIRPKQNQAPGTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE5</accession>
    <name>E8WZE5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1785</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1785"/>
    <dbReference type="EnsemblBacteria" id="ADW68833">
        <property type="protein sequence ID" value="ADW68833"/>
        <property type="gene ID" value="AciX9_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1785"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_1_0_0"/>
    <dbReference type="OMA" id="DITRPKK"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030973">
        <property type="term" value="F:molybdate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13539">
        <property type="entry name" value="PBP2_AvModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044084">
        <property type="entry name" value="AvModA-like_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27474" checksum="F7113A3F188CEDE4" modified="2011-04-05" version="1">MGRGWVKLCLVMMLGFATGFGQQKELRVAAAADLQPVMPVFAAAYEKKTGTKLLVTFGSSSALATQIVNGAPFDVFLGADFSFPERVVAAGLTDEKEPEPYAKGALVLWAKNDLGAPLSTDLLKDPRITRIAVADEFHAPYGRAAYAAMRWLKIFDDVKGKLVVGENIAQTAQFVETGNAQVGFISLTLASSDRFKKEGQFVRVPKIYPDIRQCAVVMKGSPHLAEAKDFVGWMRSTDVQEHLDQFGLEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG4</accession>
    <name>E8WZG4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1804</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580171.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1804"/>
    <dbReference type="EnsemblBacteria" id="ADW68852">
        <property type="protein sequence ID" value="ADW68852"/>
        <property type="gene ID" value="AciX9_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1804"/>
    <dbReference type="HOGENOM" id="CLU_1737988_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16409" checksum="41387B3AF79C0F22" modified="2011-04-05" version="1">MLVFDSATTAPVDVAASHPFAFVWMTVLMLILGVSRVARGIRPAVTNASSYFHLWMLAYLVVLGLLMSLTTGIALVILYDPHHYGEARPAFDWLPQRLLPLAAGAAGVLGFEWLFRKFTVGFGQTQFDLQGMLDELVNQAIAATLKKDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI9</accession>
    <name>E8WZI9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="8">3.2.1.99</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1830</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580196.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1830"/>
    <dbReference type="EnsemblBacteria" id="ADW68877">
        <property type="protein sequence ID" value="ADW68877"/>
        <property type="gene ID" value="AciX9_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1830"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_5_1_0"/>
    <dbReference type="OMA" id="GHLWAPD"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234008" evidence="7">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR026534-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR026534-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="38042" checksum="5C16EB06AD778230" modified="2011-04-05" version="1">MRFVISIYLLIALNAGSVFAQNPRSIPVKGDIQGAHDPSIARDGNTWYVFTTGKTADGGQFAVRCSRDLEHWNLCGQVFDSIPAWITTRSPGTKDLWAADISFVHGEYRLYYSYSLFGKNTSGIALATNKTLDKSNPNHKWQDRGLVFESHASDNYNAIDPNYIADKDGHGWLAFGSFWDGIKMWRLDDNSGLLSKTDSHLYDLARRKQPADADPAHPGLPPDWQAIEAPFIVRHGQFYYLFTSWDLCCRGLKSTYKTMVGRSLSITGPYLDRDGVPLSRGGGSSVLLPNKTWLGPGGESVFMDPSGSDLMVFHAYDAKDGRPGMQLSTIDWSGDWPSVVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK9</accession>
    <name>E8WZK9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="8" type="ordered locus">AciX9_2960</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581297.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2960"/>
    <dbReference type="EnsemblBacteria" id="ADW69983">
        <property type="protein sequence ID" value="ADW69983"/>
        <property type="gene ID" value="AciX9_2960"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2960"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_0"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14112" checksum="E9DDE37990A3248F" modified="2011-04-05" version="1">MPTFHQLVKQGRTPTRYKTASPALQGSPQRRGVCTRVYTQTPKKPNSALRKVARVRLTNGIEVTTYIPGIGHNLQEHSIVLIRGGRVKDLPGVRYHVVRGTLDSVGVAKRMQSRSKYGAKRPKAAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ9</accession>
    <name>E8WZZ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1849</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1849"/>
    <dbReference type="EnsemblBacteria" id="ADW68895">
        <property type="protein sequence ID" value="ADW68895"/>
        <property type="gene ID" value="AciX9_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1849"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="OMA" id="REEYCKI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="24260" checksum="BBF323E2BAE6FAD7" modified="2011-04-05" version="1">MTASTMTGFDPAAFLMSAGLGRRIVKVKAKHNFFAQGDVADCVFYLQGGRAKLTVMSSRGKEATILLLNPNDFVGEDSLAGVPGPRLATATALTQCVAMKIERVEMIRVMHEEHAFSDMFLKFLIARSIRTQADLVDQLFNSSEKRLARILLLMAEFGMPGEPESLIPKITQETLAEMIGTTRSRVSFFMNRFRKLGFIDYNGRITVHKSLLNVVLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X004</accession>
    <name>E8X004_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1854</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1854"/>
    <dbReference type="EnsemblBacteria" id="ADW68900">
        <property type="protein sequence ID" value="ADW68900"/>
        <property type="gene ID" value="AciX9_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1854"/>
    <dbReference type="HOGENOM" id="CLU_2167399_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="11494" checksum="2EF87BAE3935709E" modified="2011-04-05" version="1">MRNISPTRVAQALRPGRLAPGKLVAVLCIFLILLVGVAQVLHSHPAECSDAACSLCAVAHLAALPAAFAARPVVAEHLRPFLEANPTTGPPRLIGHSLSIRPPPVLNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X093</accession>
    <name>E8X093_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3054</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70074">
        <property type="protein sequence ID" value="ADW70074"/>
        <property type="gene ID" value="AciX9_3054"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3054"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070774_0_0_0"/>
    <dbReference type="OMA" id="FRICAGS"/>
    <dbReference type="OrthoDB" id="1348142at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="4">
        <location>
            <begin position="45"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="28045" checksum="CD04CD26ABFCAC76" modified="2011-04-05" version="1">MLTSSPAAESFAATEKEEPRPVDQQTKAALKQDNFITTTSHGLEWAKENRKSVIVTVSLLLAVIIILVAVGVIYTQRSNAAETAFGEAMQVYQAPVAIAGQPAMPGVKTYANVAERATAANKLFANVADHYGMTKDGKNARYFAGLTAAEAGQTQTAETTLKAVADGFDKDLANLAKLALADLYRQTGRDGQAVDLYNQLAAKPTNTVPAATAQIALAEMYTAEGKTEQARKIYAQLKDKDAKGVGGVLAAQKLNPAAATGPSLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A3</accession>
    <name>E8X0A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidinol-phosphate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3064</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581398.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3064"/>
    <dbReference type="EnsemblBacteria" id="ADW70084">
        <property type="protein sequence ID" value="ADW70084"/>
        <property type="gene ID" value="AciX9_3064"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3064"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_0"/>
    <dbReference type="OMA" id="FDGYPIL"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="41411" checksum="8F70BC519C6BA2B2" modified="2011-04-05" version="1">MSIAEAIKTVAPRRAILEMPEYHPPLASRDALRLDFNENTFAPSPRVMERLQTITAEGLTKYPEREPVERIVATKFGLDSKQVLLTNGVDEAIHLLCVTFLEDDDEALIWTPGFFMYDVNIQLMSPGGLRKVQSDASMQFPRERFLAAITDKTKLIMIASPNNPTGATIPCADLLAIANAAPHAVLMVDEAYFHFHGETTMGDVGDVPNLIVARTFSKAYGLANLRVGMLAGDARLIGYLRKASSPYNVNGVALTCLPVALEDDAYIAWYVDQIRTGRERIMAGLDELGVSYFPSEANFVLMQIGEKHTALVNAMRQRGVLLRDRSADPGCDGFVRITVGIADQVTQGLAALKDSLIEINWAGPVAAHDTALEREYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B4</accession>
    <name>E8X0B4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ordered locus">AciX9_3075</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581409.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3075"/>
    <dbReference type="EnsemblBacteria" id="ADW70095">
        <property type="protein sequence ID" value="ADW70095"/>
        <property type="gene ID" value="AciX9_3075"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3075"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_5_4_0"/>
    <dbReference type="OMA" id="PWHIIIV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8166" checksum="50E81110EC5CE256" modified="2011-04-05" version="1">MELFQPWHIIIVVGLAVLFFGGKKLPELGKGLGEGFKGFKDGMKGITGDDTPAASTQAKAAENAHSVTPKADEPVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F2</accession>
    <name>E8X0F2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0746"/>
    <dbReference type="EnsemblBacteria" id="ADW67816">
        <property type="protein sequence ID" value="ADW67816"/>
        <property type="gene ID" value="AciX9_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0746"/>
    <dbReference type="eggNOG" id="COG5164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793772_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001058">
        <property type="entry name" value="Synuclein"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01211">
        <property type="entry name" value="SYNUCLEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233559" evidence="2">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="15551" checksum="348A7598348D0A31" modified="2011-04-05" version="1">MASLTLASTLLMPNVSFAQTAGQDMHTAGHDTKDAADDTGHAVKTGTKKTYHKTKHVTKKAAHKTESGTVKAADKTKEGTTVAADKTKETSVKAYDKSKEGVQKVFDPSAHKKSVVTDKARESNMRAKDDVHQDTQKLKDESPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H0</accession>
    <name>E8X0H0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC C subunit domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0765</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67834">
        <property type="protein sequence ID" value="ADW67834"/>
        <property type="gene ID" value="AciX9_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0765"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_3_1_0"/>
    <dbReference type="OMA" id="WPREWKI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="12860" checksum="D7F176BAE2FF8F0B" modified="2011-04-05" version="1">MEKGGHVYILASKGKRLYTGVTSNLQIRVAQHKSKLHPTSFTARYNIDRLVYYQGFETIEEAILRESQIKNMHRITKIQLVVSHNPTWQDLSAAWGTPAPSFDETKLSAPVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J2</accession>
    <name>E8X0J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0787</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579182.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0787"/>
    <dbReference type="EnsemblBacteria" id="ADW67856">
        <property type="protein sequence ID" value="ADW67856"/>
        <property type="gene ID" value="AciX9_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0787"/>
    <dbReference type="eggNOG" id="ENOG5033UE4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530769_0_0_0"/>
    <dbReference type="OrthoDB" id="2076753at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="55455" checksum="A1BE196CABB83BDC" modified="2011-04-05" version="1">MPQSILIFRKDIRHLLPELGVVLLLFVAFASCAPSMWTASAYAPYMALLAVLLKVLMPISWVVLISRLVHDESLVGDRQFWTSRPYHWGKLLAAKILFLAVFIYLPFLLVQCYLLKHAGLHPLLALPALGHNLVLLTICVILPITALAAITSNFARLLLSVIGAIIYMLVVSGFVFYFAFLKMQLPHLQADLLAVFFLLPAVALVYQYKTRQTQRSRILLIATPIAAALIVLLPASPFIAGAYPTLSGASAPKLTSLTDQFHPPTAGTLAVVRNLVGINLPTRIEGVAEDSTFVIQGVRVTVTGGGVNYTSPFLSSQGSNPIGAKTPATLLEFSLPQDIFNRIRTTPVDIHLELATERFQMQKPATWKATLLPFSVPGNGICSFSKDDASSPPTCRFPLAPPEVSLVTADVAPRMCPATQAFPGRANLGARGGVLDFDPVITVPLSLRTGDPDPSHNYVLCPGTPLSFVEGTHLPNAILTLDQKQVVLDAFAIRLTPPTEGPAPTPQVQPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A3</accession>
    <name>E8X1A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2012"/>
    <dbReference type="EnsemblBacteria" id="ADW69057">
        <property type="protein sequence ID" value="ADW69057"/>
        <property type="gene ID" value="AciX9_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2012"/>
    <dbReference type="HOGENOM" id="CLU_2342809_0_0_0"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="11131" checksum="FF7399F207EB4A46" modified="2011-04-05" version="1">MDERTIITAEAEAQDSERTETQQRDLQFLTQWKSIEEYPACPVGIGILRQMAEVSPGAYELAVARGFDRPDHPLLQRNPLWRAFVEHRNTCGECNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G0</accession>
    <name>E8X1G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3184</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581507.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3184"/>
    <dbReference type="EnsemblBacteria" id="ADW70195">
        <property type="protein sequence ID" value="ADW70195"/>
        <property type="gene ID" value="AciX9_3184"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3184"/>
    <dbReference type="eggNOG" id="ENOG5032YXN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189062_0_0_0"/>
    <dbReference type="OMA" id="IYQRREA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7639" checksum="9D04D576D65756C8" modified="2011-04-05" version="1">MLKLLNTKFLLAILAALAVIAGAAIYQRREAERRKQADIEFRQRVEAAKKKHNAAAGNEGKTWTTYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J6</accession>
    <name>E8X1J6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3220</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581543.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3220"/>
    <dbReference type="EnsemblBacteria" id="ADW70231">
        <property type="protein sequence ID" value="ADW70231"/>
        <property type="gene ID" value="AciX9_3220"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3220"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_0"/>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="39420" checksum="C2D82CD841D2A944" modified="2011-04-05" version="1">MTDTARIAALRQAHPVARIFQAPGRVNLLGEHTDYSGGFCLPAALTFNTLIAATPRADSILTLHSLDFKTHAEFDLTALPPKGDGAWTAYPAGVAWVLQQQGIALTGADLTLSGNVPLGAGLSSSASVEVATATALLALASHTLLKPEVALLCQKAENQYVGANCGIMDQFISANGVAGNALALDTRDLTFELAPIPAHLTLVVANSMVSHSVAGGEYTTRRREVEEAAAAIGVPYLREATLADLENSRTKMSDEAFHRARHVITDSQRVLDGLAALRAGDTTRFGRLMTEAHVSYRDDFAASCAECDTLVDLALKLPGCLGSRLTGGGFGGCTVSLVEADQAETFAAALKSAYFEATKITADVFLCATADGAGEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N6</accession>
    <name>E8X1N6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0887</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67955">
        <property type="protein sequence ID" value="ADW67955"/>
        <property type="gene ID" value="AciX9_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0887"/>
    <dbReference type="HOGENOM" id="CLU_1341683_0_0_0"/>
    <dbReference type="OrthoDB" id="1950996at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="22715" checksum="9DA9D1B67B87CE87" modified="2011-04-05" version="1">MAFAPFEPAPLNHASMAEIAATLGTFPPLRIPRVNQYPAGLSYWSVTEHAQKNGGYPVAGWSVAWSPGTLISANDHCVWMREDGTLIDLMAASPGMQGFTTFLMLGDQMAADVDLRYPVVKPNFTIKLTDAPELVEAERRYERWLSLNLKLREMLKKMGWQWNPGSGWFGGNESVAAEMLGQQVYEAQRSFLELNDSIYEAPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X7</accession>
    <name>E8X1X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isoprenylcysteine carboxyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2094</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580454.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2094"/>
    <dbReference type="EnsemblBacteria" id="ADW69138">
        <property type="protein sequence ID" value="ADW69138"/>
        <property type="gene ID" value="AciX9_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2094"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_1_3_0"/>
    <dbReference type="OMA" id="FSLWLFR"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20895" checksum="148BDCBF1EB80FF5" modified="2011-04-05" version="1">MTAGRIWWVLYGLWVCGEVSILLFTRIKSSGGENRDRGSLRILWAVIMTSSFVGMSYGATHGANLPNAAQWAGWTSVALIVVGLAIRGTAIWRLGRSFSANVAITETQKLETGGLFRLVRHPSYTGMLLIFLSMGLKTGNWVSVLILTVPPVVALLYRIKVEEDALHGAFGTEYEEYCRRSKRLVPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X204</accession>
    <name>E8X204_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2121</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580481.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2121"/>
    <dbReference type="EnsemblBacteria" id="ADW69165">
        <property type="protein sequence ID" value="ADW69165"/>
        <property type="gene ID" value="AciX9_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2121"/>
    <dbReference type="HOGENOM" id="CLU_2329812_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233597" evidence="1">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10361" checksum="1BEBD407EF6A4E00" modified="2011-04-05" version="1">MLNSLTTSAHNSLPSNQVSRLLTGALLLAAAAMATGCNADEAAMHADLSGYLGHSHTWLDAADSTKADLSLLSSHHHAHSRELSRAELAPRHISNRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X259</accession>
    <name>E8X259_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3291</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70302">
        <property type="protein sequence ID" value="ADW70302"/>
        <property type="gene ID" value="AciX9_3291"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3291"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1862356_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="14662" checksum="261BEEBCB0746008" modified="2011-04-05" version="1">MQSFGKVWLFTVAESSWKSPSGTLVAKLGPLTTQTGVKYEAVYMQSIFSPGMTAPLHTHSGMEAFYTLTGDTCLETSEGVTKARGPGNAVLVQGGLPMLLMATGKEKRRGVVLILHDVAKPPTTLNPEWKPKGLCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C5</accession>
    <name>E8X2C5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0990</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579381.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68057">
        <property type="protein sequence ID" value="ADW68057"/>
        <property type="gene ID" value="AciX9_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0990"/>
    <dbReference type="eggNOG" id="ENOG5033GRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155702_0_0_0"/>
    <dbReference type="OMA" id="NATKVWE"/>
    <dbReference type="OrthoDB" id="2054876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="12283" checksum="0984887154D11E8E" modified="2011-04-05" version="1">MPSSTNTFQLVLQFEAHELEDYDHLVALEDLLIERLPRGAKVDGHDMGAEEFNLFILTSNPTELFEQVKSVVSDRFPDQNFKAAYRALTSEQYIVVWPPGLQHFEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E3</accession>
    <name>E8X2E3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1011"/>
    <dbReference type="EnsemblBacteria" id="ADW68075">
        <property type="protein sequence ID" value="ADW68075"/>
        <property type="gene ID" value="AciX9_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1011"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054701_0_0_0"/>
    <dbReference type="OMA" id="ASHCKPW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="38279" checksum="C4C0E484BD8EBF4F" modified="2011-04-05" version="1">MMHEVAKMRYWWVNQNQTYRQELEGHYLWSPKRSASGSKNPFYEFMRELAPGDLVFSFVDTRIAAIGVVASFCEESPKPAEFGRIGMNWEAVGWRASVRFTRLQREVRPKDHIDLLRTTLPLRYSPLQDSGNGNQGVYLTRVPELMAQALMGLIGIQAEDIARTAMTELGPPEAQSYKSDLEIWEHHIEQTIETAPDIPETDRQSLIIARRGQGLFKQRVSQVERRCRITHVENPAHLRASHCKPWRDSNNEERLNGENGLLLTPSIDHLFDRGFISFEQSGLLIISPVAHLPSLERMGVATHGRLNVGTFTEGQHHFLEYHRNSVLLRAAVSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W6</accession>
    <name>E8X2W6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1037</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579423.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1037"/>
    <dbReference type="EnsemblBacteria" id="ADW68100">
        <property type="protein sequence ID" value="ADW68100"/>
        <property type="gene ID" value="AciX9_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1037"/>
    <dbReference type="eggNOG" id="COG1267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103734_1_2_0"/>
    <dbReference type="OMA" id="VWDEIAG"/>
    <dbReference type="OrthoDB" id="1969080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026037">
        <property type="entry name" value="PgpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36305">
        <property type="entry name" value="PTHR36305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006162">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PgpA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="17285" checksum="05B9E8C9ECF0CC89" modified="2011-04-05" version="1">MNLRALEGKKTLWAWAVGTFFGAGLMKPGPGTYGSVAAAILWFGSIHLLHPSPLHQTIGTLIAALAATAIGIPAATIVARESGREDPGHVVIDEVAGQIFALIAIPADWPHALLALLLFRLFDITKPPPVRNLERLHGGTGIMLDDVAAGLIALAIGHAALLIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W8</accession>
    <name>E8X2W8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="12" type="ordered locus">AciX9_1039</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579425.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1039"/>
    <dbReference type="EnsemblBacteria" id="ADW68102">
        <property type="protein sequence ID" value="ADW68102"/>
        <property type="gene ID" value="AciX9_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1039"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_0"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="274"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="509"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="581" mass="64260" checksum="DAE1D10EAC58EE17" modified="2011-04-05" version="1">MPSAVLDPAISAPSKPKVGFVSLGCPKNLVDSEVMMGLLHHNGAELTPRAEDAEIIVINTCSFIDSAKQESVNTILEMVQHKQKNGGKAQRIIVAGCLVERYRDEIQKNIPEVDAVVGTGELEAILAAAGLTPTSNSPFNILPQDFNQPSIESHTQTDRALLEGNLVNETTVTQQLVHRAPSAVNQHSRPEVEGHIAPQLRIVQSLAETGTTHGDEPLAHTGDHIQRGIDPGNTSRPEGDLRQQQGRFSRESWDGATAALPEYLYNDATPRILTTPRASAYIKIAEGCDHPCSFCIIPQLRGKFRSRRMGSIIAEAQNLIAQGVREITLIGQDTTCYGEDLGLKEGLAQLLDGLAVLPGLRWLRFLYTYPNKVTTRLLETMARHDTISKYLDVPLQHASPNVLKTMKRGGNAQIFLNLIAKARQIVPGIVIRTSFIVGFPGETEADYKLLEDFVKAARIDWLGVFTYSDEEGAKAFELPDDTKVPNRTIQARRRKLMKLQQKISTTEKLKWVGREIDLLVEGPSEETDLLWEGRTSLHAPEIDGKVFINDFGPHEELVPGTFYRAEITESHDYDVVARILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z2</accession>
    <name>E8X2Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1063</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579449.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1063"/>
    <dbReference type="EnsemblBacteria" id="ADW68126">
        <property type="protein sequence ID" value="ADW68126"/>
        <property type="gene ID" value="AciX9_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1063"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058803_2_0_0"/>
    <dbReference type="OMA" id="GQCVHKI"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="371" mass="40959" checksum="41E549EA6B08B4D3" modified="2011-04-05" version="1">MSGVRLLVGTKKGAFVLTADGGRVDWTIEGPFFAGWECYHVAGSPVDAERIYCSQSSAWFGQVMQRSDDGGKTWAAVGNLFGYEGKTGTHQWYDGSPHPWEFKRVWHVEPSLSEVDVVYAGVEDAGLFRSVDGGVRWEELNGLRGHGTAVDWQPGAGGMCLHTIVIDPSDERRMFVAISAAGAFRTDDGGVTWKPVNKGLRSQYIPKPDAEVGHCVHKLAMHPARPQTLFMQKHWDVMRTDDAGENWREVSGNLPTDFGFAIDVHAHEPETIYVVPIKSDSEHFPLDGRLRVYRSKSGGDEWEAMTKGLPQSDCYVNVLRDAMAVDRMEECGVYFGTTGGQVYCSADGGETWRTVVRDLPAVLSVEVQTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X320</accession>
    <name>E8X320_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579477.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1091"/>
    <dbReference type="EnsemblBacteria" id="ADW68154">
        <property type="protein sequence ID" value="ADW68154"/>
        <property type="gene ID" value="AciX9_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1091"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051806_2_0_0"/>
    <dbReference type="OMA" id="HAAWDWA"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="36696" checksum="1DF31A3B330C5CF5" modified="2011-04-05" version="1">MEPIEPNQAPAITTPEPPTLRRLFLGDDGLRAGWSFALYLLLVALIAFSLKAAILHFHLLPTPTKNAAPHDMTPRSAIIGDGINFAVMALAAWLMSFIERRPFSRYGFSLRRALPDFLIGILWGFAMLSALAGTLLLTHHLAFDGILLHGHAAAIYAAKWALGFLLVGLFEEFGFRGYFQYTIARGVSGIARTMSPNFRHAHAVGFWVSAFIFSMVLFTLTHVGNSGETLEGILAVAGAGAVLVFSLYRTGTLWWAIGWHAAWDWAQTFFYGTPDSGLHGVGHLLGTHPTGSTFLSGGSAGPEGSLFVLPTLALTALVIHLTLPRRTYPLTPDQSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X340</accession>
    <name>E8X340_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2222</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580580.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2222"/>
    <dbReference type="EnsemblBacteria" id="ADW69264">
        <property type="protein sequence ID" value="ADW69264"/>
        <property type="gene ID" value="AciX9_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2222"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033976_2_0_0"/>
    <dbReference type="OMA" id="HEYLEGY"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10231">
        <property type="entry name" value="YegD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042054">
        <property type="entry name" value="YegD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="445" mass="48733" checksum="E35943BFCEA763F9" modified="2011-04-05" version="1">MPSPDTKHDPGPAVGPAYAVGIDFGTTNSSVARIVNGHVELLTLSTPTIKPSPSSRSLLYLEKAPKGILSSTGPHAIERYLSAHREGDRPGRLIQSLKSYLPSRSLTGTEVFGRHYTLEDLISRILLDLRQAAEHQFNHPITRATVGRPVRFVGAETEEDETFALTRLRAAFTRAGFTHIDFEYEPLGAAYSYQSTLTHPETILIGDFGGGTSDFSILTLGPLHSSQERQVLGTAGLPFAGDAFDARIIRNLVSPALGSNSFALGLNKTLPAVPAWIYANLERWHYLSFLRTRNVLEILTSAQKRAIEPEKIQALLALVEEDLGYQLHQAVQRTKVALSHEEEAPFNFSGPDAGTMDLRTTVHRADFERWITPELLQIAETVDTLLETAKLPPQKIDRVFLTGGTSLVPAVRSIFETRFPTRVTAGDEFTSVAQGLALKAAETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X379</accession>
    <name>E8X379_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ordered locus">AciX9_2265</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580619.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2265"/>
    <dbReference type="EnsemblBacteria" id="ADW69303">
        <property type="protein sequence ID" value="ADW69303"/>
        <property type="gene ID" value="AciX9_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2265"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_0"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="45633" checksum="C9DFCB69798D674C" modified="2011-04-05" version="1">MDKFVVRGGNPLLGTIKVSGAKNSALPCMAAAILTEDELILENIPQVQDIETERKLLVSMGAEVQLGYGRAQHRTHIKCAVLSDPVAKYEIVKTMRASSLVLGPLIARTGIARVAMPGGCAIGGRPIDMHLAALEQMGATITQDHGYLEARTNRLKGAHIVFDKITVTGTEDILMAATLAEGETILENCAREPEVTDLAALLLAMGAKIEGAGTSTMKIQGVTRLHGARHKINPDRIEAGTFLMAGAITGGDLNVDCCDPSHLGALIAKLEQMGVRIDVGKDSIRVRSGGELKAADISTEEYPGFPTDMQAQFMALATQAEGTTNVTENIFENRFMHVQELNRMGANISVQGRTATVRGKTPMQSAAVMCSDLRASASLVLAALVADGESILDRVYHMDRGYERIEEKLRGVGAQIRRMGDVFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X393</accession>
    <name>E8X393_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2279</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580633.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2279"/>
    <dbReference type="EnsemblBacteria" id="ADW69317">
        <property type="protein sequence ID" value="ADW69317"/>
        <property type="gene ID" value="AciX9_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2279"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_0"/>
    <dbReference type="OMA" id="HAFVNDQ"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="163"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="705" mass="79460" checksum="C9159C2F5B5B2823" modified="2011-04-05" version="1">MPRKLLPGRPYPLGAKVSSKGTNFAIYSEHATGVEVCFFDEDGKQTDCVALQEHTAYVWHGLVLGVKAGQRYGYRVDGPWDPANGQRFNKAKLLVDPYAEAISGDVDWKAPIYPYDVASGDDMKRDDQDSQAGVPKSVVVSHKFDWGEDCPPDTPLADSVIYEVHVKGYSERNPMVPEELRGSYAGLAHESSINYFKKLGVTAIELLPVHHFIDDGHLLDKGLSNYWGYNTLGYFAPMARFSSSGDTGGQVVEFKEMVKKLHAAGLEVILDVVYNHTCEGNEKGPMLSMKGVCNTTYYRTVDGDARFYMDYTGTGNTLKVHNPQVLKLLMDSLRYWVTEMHVDGFRFDLAATLARGLHEVSKLSAFFETIHQDPTLADVKLIAEPWDVGEGGYQVGEFPVLWAEWNGKYRDTVRRFWKGDDGQLSDFAYRLTGSSDLYQSDGRKPYASINFVTAHDGFTLCDLVSYDQKHNEANGEDNQDGANENDSWNMGAEGPTEDEGINILRERQTRNFLATLMLSQGVPMLAGGDEVARSQMGNNNAYCQDDELTWYDWNLDSPRRRLMEFTANLIQMRRNHPNLHRRKFFQDRTIRGSVVRDIAWYNTTGEEFSDENWNSSWSKSLALMLNGKTLNVSDEEGNKVEDDSFLMLINAFHEGVEFTLPPPPNGNPWKYVLNTENLEDPFQKSDVGEKITVGGRTFVMLSDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D6</accession>
    <name>E8X3D6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mn2+/Fe2+ transporter, NRAMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3431</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3431"/>
    <dbReference type="EnsemblBacteria" id="ADW70437">
        <property type="protein sequence ID" value="ADW70437"/>
        <property type="gene ID" value="AciX9_3431"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3431"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_0"/>
    <dbReference type="OMA" id="IATFVNS"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="48611" checksum="F76E4E3EC65230F6" modified="2011-04-05" version="1">MNESSTASTPRRHEMWKFFGPAFVASVAYIDPGNFATNIQGGTQFGYRLLWVLLWSNAMAILVQYLSAKLGIVTGLTLPQNCRKYFSRPTTICLWAAAEIAAIATDLAEFLGAAIGLDLLFGPLLYAHGFSPQATLLIAALVTTVAVFGILALELAGHLWLERGIIGLVAVIGLCYGFEVVLVHPDWHRAFLATILPSLDRSSPKALHDSIYAAVAMLGATVMPHVVYLHSALVQPRLKQLTGSDVPSNLRVQAQTGEASRSRETREILSRFLHFELIDVFFAMNGAWLINSAMILMAAVAFAHTGNLQPTIQDAYRTLGPLFGRSAAIIFAVALLCSGLSSSTVGVMAGQVIIEGFLDIKFPILLRRLVTIIPALLVIGIGLDPLKILVLSQVVLSFALPFALIPLLLLTNRVSVMETFVSSTRTRIAGWIVVVIILALNGLLLSQIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D8</accession>
    <name>E8X3D8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ordered locus">AciX9_3433</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581751.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3433"/>
    <dbReference type="EnsemblBacteria" id="ADW70439">
        <property type="protein sequence ID" value="ADW70439"/>
        <property type="gene ID" value="AciX9_3433"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3433"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_0"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="429" mass="45121" checksum="81CCD94B89E0730E" modified="2011-04-05" version="1">MKILVFGGGGREHALIWALRKSSRVSEIVCAPGNGGIAAVARCVPAEMNNLASMLQVVEAEVPDLVIVGPEVPLAEGIVDALVDRGIRVFGPTKKAAQLETSKGFAKDFMQRWEIPTAAYAVCTTKEQVEQILAAEGSGFGASVVVKADGLAAGKGVVMCDSHGEAVSAAAEMFSGGLLGERAESVVIEETLTGPEISFFAICDGRKAVTLATAQDHKRIGEGDTGPNTGGMGAYSTDDLITSEMSAWLLEHVAQRVVDGMAKEGSPFSGVLFCGIMLTPDGPKVLEFNTRFGDPETEAMMLRLETELLDIIEAAVDGRIDQIAVRLRPGASACVIAASGGYPGKIVSGYAIHGLDLVRGEVHVFHAGTAKSEEEIVTAGGRVLGVSAAGNDLREALGRCYAALEVLQFEGMQFRRDIGWRALKDLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E5</accession>
    <name>E8X3E5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease R</fullName>
            <shortName evidence="4">RNase R</shortName>
            <ecNumber evidence="4">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rnr</name>
        <name evidence="8" type="ordered locus">AciX9_3441</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581757.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3441"/>
    <dbReference type="EnsemblBacteria" id="ADW70446">
        <property type="protein sequence ID" value="ADW70446"/>
        <property type="gene ID" value="AciX9_3441"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3441"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_2_0"/>
    <dbReference type="OMA" id="CTYNEVQ"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="815"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="961" mass="108064" checksum="9A7B9B1373C1451A" modified="2011-04-05" version="1">MPNSPYPQSDRDLIRFIERSPSHRAGYKQLIRELGLGGGRERRLLLEQLARITLRGDLVKIDDGQWALPRATPDKTERPGAPRPDSGTWDRGTRPHGRITRENLVAGKLDLHRDGFGFVRPNGSSKREDDLFIPPHELNGAMQGDEVLVDEAPPAVDGRRSGRIARILTRRNTTVVGIFHYARGRGSRGTTPDSYNTANFHYIVPLDERMTQPILIESAPDGQPTLPATPAESQHRVLGEEARRELSFDPSLPHFLEGLAVDVEVTSFPTESRPAQGRILEILGHPDAFGVDVEIVIRKHHLPYAFPANVLAEAAASADQTVDTLTPEDLSLRHDFRGLPIVTIDGETARDFDDAILVQPLPNGNWQLQVHIADVSHYVRPGTDLDLEARLRGTSVYFPDRSVPMLPPSLSSNMCSLRPDEDRLVLSCIAEIDNHGEVVDYQLCEGIIRSARRMTYTQVQSILDTSSTTPPPGAPRPDSGTWVSAYLSTDLSPAESEKHTRDLETRLQFLDLAPAFEQMYDLALKLNRKRHRRGSIDFDLPEPVIRFDPQGNMAAITRSERGWANRLIEEFMLTANECVAHWLEALGPSIYRIHELPDAKRILDFEEVAATYGQTLGFSSLPVKKLTMKSDRRSNRAASERHGGRTRQAQSHEIPESIPVTPLMYQKLTAKIAGTPEERILSYLMLRSLKQARYSEKNEGHFALASPSYTHFTSPIRRYPDLIVHRLIRAALHANANPNGQPIFSTDPQPWSSKRSSTKPGAPRLASETWVSTTLPPEELAAISLESSQSERRADDAERELMEWKKIKFMQDRVGEEFHATVLSCTKYGFYVELDDLFIEGMVPIQSLSESLPFGDPDRFFFRDTDRVIVASHSGRVFKLGQRVHVLLDRIDRPNRRLQFALVPSRTPQGESPRSLRKPKATPARRETFSSPTRTGKPSRTKTKSKTRLRDKKAKGKGKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I6</accession>
    <name>E8X3I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1114</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1114"/>
    <dbReference type="EnsemblBacteria" id="ADW68177">
        <property type="protein sequence ID" value="ADW68177"/>
        <property type="gene ID" value="AciX9_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1114"/>
    <dbReference type="eggNOG" id="ENOG5033NFR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120032_0_0_0"/>
    <dbReference type="OMA" id="GWRVNRE"/>
    <dbReference type="OrthoDB" id="1897377at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16236" checksum="36587900C90EDE07" modified="2011-04-05" version="1">MTNIATAMTPDTLYRLAPPLIALQFAAFGWRVNREINLGDAARATWIPIPDVLNIMSLFATVLCLIVLPIATDSYLWLSRMVLGAGYILIAFHPFTMAAHYRLWSKEGRSKYITDGKAYPYATREELISSSLSVVLAALAAAYIGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K5</accession>
    <name>E8X3K5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">AciX9_1133</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579519.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1133"/>
    <dbReference type="EnsemblBacteria" id="ADW68196">
        <property type="protein sequence ID" value="ADW68196"/>
        <property type="gene ID" value="AciX9_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1133"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_0"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="42367" checksum="2E74C9032273514B" modified="2011-04-05" version="1">MLRFSTAGESHGEALVALVSGLPAGVPVDQVRLDRELWRRQQGYGRGGRMRIEKDTAHILSGVRHGKTIGAPVAMTLANVDWKNWEEILPVDTGDATKHKAVASPRPGHADLAGALKYDFPDARYVLERASARESAARVACGALAKMLLGELGILVGSHVVRVGGEELGRDAAWAEIAASNAKDEIFLNCVDAEAEARMKGEVDKALRTGDTIGGVFEVVVHGLPPGVGTHVNWDERMDGLLAQAVMSLQAVKAVELGRGVTAAESLGSTVHDAISYEQGDAEPEDGGAKFTKFTREKNNAGGIEGGISNGEDVVVRGYLKPISTLRRPLASVSFETREATKAAYERSDVCVVPAAGVAAEAMVALTIARLVIDKFGGDSLGELKRNYAGYCEQIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P6</accession>
    <name>E8X3P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2286</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580640.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2286"/>
    <dbReference type="EnsemblBacteria" id="ADW69324">
        <property type="protein sequence ID" value="ADW69324"/>
        <property type="gene ID" value="AciX9_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2286"/>
    <dbReference type="eggNOG" id="COG4181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26333" checksum="AE084E87A293B1F9" modified="2011-04-05" version="1">MPPSPTAVTPAAQQDVIQVKSLRKSIRNGTRTVDILKGLDFAIPHGQFAAIMGTSGSGKSTLLGLLAGLDTPTSGDVILNSQPISYLPEDQLAQVRGRTIGFVFQSYQLIPTLTALENVLLPHELNADASKQDGLTRARTLLTSVGLGDRLDHYPVQLSGGEQQRVALARAFVLRPPIVLADEPTGNLDTTNGAHILELLLNLNKTEGTTLVLVTHDPVLATYADRVITLRDGLIVSDTLNPNPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R5</accession>
    <name>E8X3R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2306</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69343">
        <property type="protein sequence ID" value="ADW69343"/>
        <property type="gene ID" value="AciX9_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2306"/>
    <dbReference type="HOGENOM" id="CLU_3099376_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5548" checksum="D1C9F865581B50B5" modified="2011-04-05" version="1">MSERSKALTGQLSDHTDLVPAGQYGSREMMKITLAKEDLAAQARFSILIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S5</accession>
    <name>E8X3S5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea carboxylase-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2316"/>
    <dbReference type="EnsemblBacteria" id="ADW69353">
        <property type="protein sequence ID" value="ADW69353"/>
        <property type="gene ID" value="AciX9_2316"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2316"/>
    <dbReference type="eggNOG" id="COG3665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079904_0_0_0"/>
    <dbReference type="OMA" id="RGFENNA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017792">
        <property type="entry name" value="Urea_carboxylase-assoc_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03425">
        <property type="entry name" value="urea_degr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26567" checksum="32F140BD97E04A3B" modified="2011-04-05" version="1">MTQEKHETLWTETLPGNATWSHILKRGTSLRLTALDPNPNVAAILLNADNFSERLNLPDTLKAQHIARLTTGAVLYSDMARILCSITADTVGWHDPLGGCSDAAMVAAKYGELPYQQARNAWHQNALDGFLIELAKYGLGLRDLMMNVSFFSKVEVHDDGSMHFIPNNAAPGTSVEIRAEMNTLVILNSCQHPMDPSPDYAAKQVELTLSKVPAPGPDDVCRNFRPENTRGFTLTERYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U1</accession>
    <name>E8X3U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2332</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580685.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2332"/>
    <dbReference type="EnsemblBacteria" id="ADW69369">
        <property type="protein sequence ID" value="ADW69369"/>
        <property type="gene ID" value="AciX9_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2332"/>
    <dbReference type="eggNOG" id="ENOG5032EAH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874434_0_0_0"/>
    <dbReference type="OMA" id="LRWHLAV"/>
    <dbReference type="OrthoDB" id="1657421at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="15174" checksum="620CCF934FCDF939" modified="2011-04-05" version="1">MAASLYIVVEGEDPGFDIFVNGRLLARHEDSLERLALSLGVKPLIEYFSADENSMSLLIEEGAGNEELIKRLPPPQWYGGAEGLTTIDALVDALAEEPHKLGSEGPMVLDELKEYARVLRKTEDRGLRWHLAVSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y6</accession>
    <name>E8X3Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3489</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581805.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3489"/>
    <dbReference type="EnsemblBacteria" id="ADW70494">
        <property type="protein sequence ID" value="ADW70494"/>
        <property type="gene ID" value="AciX9_3489"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3489"/>
    <dbReference type="eggNOG" id="ENOG503348D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183667_0_0_0"/>
    <dbReference type="OMA" id="MFPGKEL"/>
    <dbReference type="OrthoDB" id="2007594at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10821" checksum="117BB382FC33E096" modified="2011-04-05" version="1">MQTENTASQPLPKPDAQQETQEENRLIRRLQLMMNLVMQTIAQDGSLSVDDASQMIADARKAALAMFPGKELAYELIWRPRFQRLMQERFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X416</accession>
    <name>E8X416_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3519</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581835.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3519"/>
    <dbReference type="EnsemblBacteria" id="ADW70524">
        <property type="protein sequence ID" value="ADW70524"/>
        <property type="gene ID" value="AciX9_3519"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3519"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_1_0"/>
    <dbReference type="OMA" id="NGRTDCF"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230211" evidence="1">
        <location>
            <begin position="24"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="57"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="34014" checksum="D896E28E8E930673" modified="2011-04-05" version="1">MKPSYLLPLVIICALTAGSIAQTAPPTPPPPAPANAFYPEKELPAPFNPALPTIFIVGDSTASYHPDRTDEGAAAIQGWGYFLPAFFDPTRVNVVNAARGGRSTRTYMTEGLWQKVLAQVKPHDIVLIQLGQNDVFELNDKSARGTIPGIGDQTQEIDNIVTHKHEVVHTFGWYLRNYVKQAREKGATPIVMSLTTRNVWKDGQVEVGVNNYRESSWRIANSEGHTDFVDVSEIIAQAYRKLGPDKTAGLFHTREQVHINTAGAFLDTRCIVAGLEGLTDAPITPYLSYLGQEITPVSPPIPTEWSQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8X426</accession>
    <name>E8X426_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ordered locus">AciX9_3529</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581845.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3529"/>
    <dbReference type="EnsemblBacteria" id="ADW70534">
        <property type="protein sequence ID" value="ADW70534"/>
        <property type="gene ID" value="AciX9_3529"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3529"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_0"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="62"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="306" mass="33979" checksum="85FE1A9861BD8669" modified="2011-04-05" version="1">MAPALELVQIDLSPKVPVRKPEWLKARAPGGETFHALKKMARDLNLHTVCESAHCPNIGECWNQKAATFMMLGNLCTRRCGFCAVPKGKPEPIDHDEPRRVAYAVAQLGLAHAVITSVNRDDDNLGAAQAFVEVIEQIRLQSAGTRIEVLTPDFQGNEQSLRMVVAAKPEILNHNIETVPRLYRIAKSGGKYPRSLRFLEQAKEIAAETGITQVTKTGIIVGMGEEMHELLAVFRDLADRKVDILTIGQYLRPSKDHLVMSRFYTPEEFAFLKQEALAMGFRHVESGPLVRSSYHAQEQAESTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X458</accession>
    <name>E8X458_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ordered locus">AciX9_0027</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578447.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0027"/>
    <dbReference type="EnsemblBacteria" id="ADW67118">
        <property type="protein sequence ID" value="ADW67118"/>
        <property type="gene ID" value="AciX9_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0027"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_1_0"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="1165275at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="113"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="153"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="388" mass="41686" checksum="2232A9EDD2009D53" modified="2011-04-05" version="1">MKAGTPLLPGATIGIFGGGQLGRMMAMAARGMGYRILVLDPDPGCPARFIVDGCIEAGWDDSRGAAMLARGCDVVTLEIEQIGERSMASAATFCPVRPGGAMLAIIQDRIEQKNWLTKHGFPVGEFRAVRSLDETRAAIAELGRCFCKSATGGYDGRGQGKVGFSAEPVTEADVLGAWEALGEGPGVVEKAVHLEREISVMVARSPRGEVKVYPAAWNHHENQILDWSVIPAPIPPSMEAEAREIAYEIADTFQLEGLLAVEMFITQDGELLINELAPRPHNSYHESERACVTSQFEQAIRAVCDLPLGDVEVVQPAAIANLLGDLWLNPDGSAREVCFDKALAVPGVALHLYEKLKPRKGRKMGHLSAIGATAEQAIERVLRAKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C9</accession>
    <name>E8X4C9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1193</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579579.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1193"/>
    <dbReference type="EnsemblBacteria" id="ADW68256">
        <property type="protein sequence ID" value="ADW68256"/>
        <property type="gene ID" value="AciX9_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1193"/>
    <dbReference type="eggNOG" id="ENOG5032YTR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021694_0_0_0"/>
    <dbReference type="OMA" id="YERGSFH"/>
    <dbReference type="OrthoDB" id="1942563at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="14203" checksum="91466C339CA077AD" modified="2011-04-05" version="1">MGKLLKSYVFWTYDRGSLHYDVMVTAILIFMFGAPRLMNFKDKPVETVALHSSEVLVKEAGTTSAGSSRFVYQVRAEDLGNAKSDTELRVAILRVVEPVSGEVTVEKYEPVRNATGDIIAYNAWVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F3</accession>
    <name>E8X4F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1217</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579603.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1217"/>
    <dbReference type="EnsemblBacteria" id="ADW68280">
        <property type="protein sequence ID" value="ADW68280"/>
        <property type="gene ID" value="AciX9_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1217"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813211_0_0_0"/>
    <dbReference type="OMA" id="ECPLRCP"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="341" mass="37700" checksum="DBA4DE8E5A6A108C" modified="2011-04-05" version="1">MKKSEVFHAWASILSGRAPSLSIEITKECPLRCPGCYAFDAAHLGGSTQLRQLSDFKGDELVQKVLAVIDEHKPLHVSLVGGDPMVRYRELELLLPQLESRGVHTQIVTSAFRIIPPAWKQYSKLNVVVSIDGLQPEHDARRAPATYDRILKNIAGAKVTIHCTVTSQIVDRPGYLDEFLAFWSARPEIAKVWFSIFTPQIGATDPEILTPAQRTAVIAELRLLRVKYPVLDMPEIVIDEIANPPRNPDECIFARTTETISADLTTQITPCQFGGEPDCQQCGCIASVGLAAVGHYKIIGPLTAGHIFMASDRFGKGWRKLQRSFAPKPVVTQQPAPFKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F5</accession>
    <name>E8X4F5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1219</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579605.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1219"/>
    <dbReference type="EnsemblBacteria" id="ADW68282">
        <property type="protein sequence ID" value="ADW68282"/>
        <property type="gene ID" value="AciX9_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1219"/>
    <dbReference type="eggNOG" id="COG1069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_9_1_0"/>
    <dbReference type="OMA" id="GHKAMWH"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="271"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="56457" checksum="2FFA96402C1943D4" modified="2011-04-05" version="1">MAIVAGVDFGTLSVRVTLLDSERGRLGTAAAGYPLHRRREDPDYATQSHDDQMNALVEATKAVLAQAGVAGTEVVALALDTTGSSVIPVDAQVQPLDEYLLWCDHRAHKEAQRITELAHEQGLEAIEWCGGVYSHEWGFAKLLYWLRNNPEKRERFATALEHCDMVAATLIGITDVAEVPRSICAMGHKWMWNPRWGGLPSQEFLSSVDPLFDGVREKLTGIYSTSERVAGGLSAEWAERMGLKAGIPIPVGAFDAHWDAIGAGCKEGDVVNVVGTSTCIIAMAKTTSLIPGVCGIVPGSVHPEFVGIEAGMSATGDIFEAIAKRAGTDVKALSQGLDQYAAGQTGLLRMSWDNGDRTVLVNPELGGMTLGWNLGHTAQDELFASIEGTAFHTRIILERMAEHGVPVDRVINGGGIPQNNTVLNQVYANVLGKTVLVPDGTPTSLGSGIFALVAAGVFASIEEAQAKMCLAFRTYEPEAAAVARYDELFEIYKAIYFAFGAKDGAAVAMGHVLPELRRIAVEARKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R0</accession>
    <name>E8X4R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3545</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70549">
        <property type="protein sequence ID" value="ADW70549"/>
        <property type="gene ID" value="AciX9_3545"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3545"/>
    <dbReference type="HOGENOM" id="CLU_3043936_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="5875" checksum="526F307CD42F18BE" modified="2011-04-05" version="1">MHTPKLPLNVTHVELIKDCGIIICFSDDTSAAYTSEELACLRPYRAPLLAANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U7</accession>
    <name>E8X4U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3582</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3582"/>
    <dbReference type="EnsemblBacteria" id="ADW70586">
        <property type="protein sequence ID" value="ADW70586"/>
        <property type="gene ID" value="AciX9_3582"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3582"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116623_4_2_0"/>
    <dbReference type="OMA" id="IYDQTYH"/>
    <dbReference type="OrthoDB" id="1802106at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13433" checksum="06C965C8620402AE" modified="2011-04-05" version="1">MTGIEKELEKELQMSGQAQSISVDIYDQIYHLRGTDPAYIEHLAGLVDAKMRAVSAHGGTVDSLRVAVLAALNITDELETLRERYNALARSQSQTQTTMRSRSASLSGMLDEVLDEPIRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X511</accession>
    <name>E8X511_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin iron-sulfur binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0126</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578531.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0126"/>
    <dbReference type="EnsemblBacteria" id="ADW67203">
        <property type="protein sequence ID" value="ADW67203"/>
        <property type="gene ID" value="AciX9_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0126"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029605_0_0_0"/>
    <dbReference type="OMA" id="VACNEQN"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019645">
        <property type="term" value="P:anaerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007059">
        <property type="entry name" value="DmsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04976">
        <property type="entry name" value="DmsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="529" mass="56620" checksum="77BEEE2F0EAB0085" modified="2011-04-05" version="1">MNLPLHERAVEGTSPALVRMTGLSLGEHGILFPEVVSALIPARKPGPGEQYRFHFDMTKCIGCRSCEVACNEQNNNPADILWRRIGELEAGSYPDTQRHYLSMGCNHCLDADCLKGCPVDAYTKDPVSGIVLHSADACIGCSYCVWNCPYSVPQYNPERGVVGKCDMCKGRLDDGLEPACVNACPEGAIEIELVNMAEWRSDYALADSPGMPAAEQTVSTTRITLPHIPSAGLERVDLGQIQREHAHVPLIYMTALMQAVSGALWVLIAWHALDAVRLFVLLTITATALTLSTLHLGRPAFAYRALKMWRRSWLSREVLLFTLFFAALAAATVAAAAREYGVVLPIALPLALSLTAAILGVLGTLASAAIYLVKARPAWNTAHTPADFILTAALLGSLLAAALAGTTLRLPIFPTFATATPNALALILLCAGSWLINQTVRAVRLRRAAAFEARAAWALLSGDATWPVAAGCVLLLLFALIATADGSAPIALGLAFASVLLSRYLFFVTVVPLNMALTFVRSRPAGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X573</accession>
    <name>E8X573_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579660.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1275"/>
    <dbReference type="EnsemblBacteria" id="ADW68337">
        <property type="protein sequence ID" value="ADW68337"/>
        <property type="gene ID" value="AciX9_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1275"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="INDHQKT"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233692" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1269" mass="135668" checksum="0F246A874881CBC4" modified="2011-04-05" version="1">MRTRSTRLNAALLFALPLAAISAPLIAQNNTSSLSGTVTDNTGAIVPGANISIENAATNKTQTTQSQSKGEFSFDQIAPGTYQVHVTAPGFSEQLQKVELLVATPVKLTFKLSVGTSEVVNVETNLAEVNTTDATLGKAFNSAQVQNLPYLANNVTYLLSLQPGVLALDSGAQTGGLNTDPRTGIVNGARQDQSNITLDGVDNNDQVFGYAFNGALRSTRDSVEEFRVTTTNANADSGRSSGAQVSLVTRSGTNTFHGSAYEFYRDPATTSNNWFNKQAQLNSGLPNTAAKVLEHTYGASFGMPIKKDKLFFFAAYEGFKQASSILVSQTVPSVLGGAGLVTGNVVYSACPTSATCQNGTVLKTLTPADIASLDGRASDSACTPISACAAPSTNAAAVAYFKTFPLANSNATGDGYNTGTYNFTSPAPVHQITNIVRLDYNLSPKQTLFVRGNLQSDNQAAALQFPGQVGASNTYGNNKGIAAGDIWNISDHLINNARYGFTRLGNANRGTADFSKPYVEFGAFATRTPETTTTIYDVTTNNFADDITYTKGRHTIQAGVNLYFISNGQYFDSPLLSLAIIDPNLLATAAIANQGGTLDPGAFACADCGTVSSSFQNFYNSSIIANVGAITRSQSGTEFALTNNSLVPLGAGVVPTHTFVNKEQEYFIQDQWKATQHLTLTFGLRYVYLGVPYEKNGQQIAPTIPLDTFLANRESAAAAGSAYTTRISFRASGSPNGQPNFWTPQKANFAPRVAFAYSTPDNKSSIRGGFSLAYDHFGSGVIDSYQSNANSLLSLSKANRTSFSDINTSPRFTGYNIVPPVPGATTALQLPNTPADSAFSFDTSINDHQKTPYAESFNLTLEHEFHHNLDVTASYVGRLGRHLLSNIDVAQPTNLVDPASGQSYFQAATAYAKLIDAGVSPATIQNTGYFKNVFPNLTYQYQAATSSTPALYYYGAQAYYASLADNRGNETNALFNADTDPTTSPAGQSFRFFYPQTSSIYVQSTIGTSNYHALQLSVRQALGHGFEYDINYTYAKSMDLGSDPERSGEGASPILNTFSPAQMYGVSDFDVRHNITANYTLPLPFGAGQMFLHNGGLLERIIGGFQLNGVVHYSTGFPFSAVAANTYGTNFAFSSNMVQTGPIPTGGHHYDAPNLTETALNGVTSAQALANLRFAYPGESGQRNNFRADGYLSIDDGLSKSFRTFREQQFRISAEVFNVLNTNRFNSGGGNNPALQTDGTSSNFGAYIGGPNALLLQPRQMQFSGKYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A9</accession>
    <name>E8X5A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579696.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1311"/>
    <dbReference type="EnsemblBacteria" id="ADW68373">
        <property type="protein sequence ID" value="ADW68373"/>
        <property type="gene ID" value="AciX9_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1311"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087351_1_0_0"/>
    <dbReference type="OMA" id="VRAMYTH"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="19757" checksum="16CC5C6E2BAEDA39" modified="2011-04-05" version="1">MPIHIRPLRTDEIPQITALIRASVRGLQAGDYDEAQREAAIATVFTVDTRLVADGGYFAAETEDGILIGCGGWSARKTLYGGDHQLEDKAPDWLDPAVDAAKIRAIFVHPDWARQGIGAMLLHAAEQAAHTAGFRRYEMGSTLTGVSLYKRSGYRELERIQVPVADGQTIEIVRMTKDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E0</accession>
    <name>E8X5E0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2452</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2452"/>
    <dbReference type="EnsemblBacteria" id="ADW69487">
        <property type="protein sequence ID" value="ADW69487"/>
        <property type="gene ID" value="AciX9_2452"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2452"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019505_1_0_0"/>
    <dbReference type="OMA" id="PCVPYAG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="18091" checksum="FB5BE871A9FD913F" modified="2011-04-05" version="1">MTMTGTEGRFFGKFRGTVVNNVDPLFMGRLLVECPDVLSLAPSSWALPCTPLAGPTGTGAGAYLVPAIGTGVWVEFEKGDPEYPIWAGCRWGSSSDVPPLALVGLPVSPSIVFQTIGQNTLMMSDVPGPLGGILLKGTTGALISITELGITISNGQGASISMIGPTVTVNAGALVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G1</accession>
    <name>E8X5G1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2475</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2475"/>
    <dbReference type="EnsemblBacteria" id="ADW69508">
        <property type="protein sequence ID" value="ADW69508"/>
        <property type="gene ID" value="AciX9_2475"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2475"/>
    <dbReference type="HOGENOM" id="CLU_3118375_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="50" mass="5607" checksum="71EC56A519C4FE49" modified="2011-04-05" version="1">MNFQTKLLTQILTQTVAPAIPHPSHTPPNLNPSPKYRILIIGRNPGRHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N1</accession>
    <name>E8X5N1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3655</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581969.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3655"/>
    <dbReference type="EnsemblBacteria" id="ADW70658">
        <property type="protein sequence ID" value="ADW70658"/>
        <property type="gene ID" value="AciX9_3655"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3655"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269339_0_0_0"/>
    <dbReference type="OMA" id="INCAIAN"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1214" mass="126908" checksum="3549571753A39411" modified="2011-04-05" version="1">MRKFFGVGAMAVVMSVASYGQNVSTNGGSIQGTITDPSGAAVPGAEVKVFGTDTGFSRTLKTDGAGYYSIGPLTPGAYKVTVSSAGFQSLAVTTVIRVGTTTPGTFKLSLGQSSETVEVNAGSIQVNADQPGVSDVLTSQQIESLPINGRNFLDVAQIEPGVILQAGGSFDPTKAGYSALSVGGVSGRTTRILLDGQDITDETVGTTIFNVSQGAIGEFQLNRSTQDVSGDVTSTGQVLVTTKTGTNGFHGELFYNFQDSRALFATEFGSQPPFQRNQFGGSLGGPIIKDKLFFFGNLERIKQDAAQPAGVSSTFSQYVGLNVPSPYRETYSTVRLDYNGPKGGHYFVRANYNVNAVAGNFGEQFETYANRDNTPGIAGGVDYQFGRFTHSFRGSFEKFHNLISDTSSTAAVNLLPGIAYQNVVGTSPLLSTGPNVDAPQGTFQSDKQARYDGSWTKGTHTIRYGYSINYILGGGFANFFGLGPRLRTNSATLLANCGNVAGAAACPGDPLNGYHTSSLIIGNGLGYFTENPGFGANFGGVHDWREGAYVADSWKATPNLTVSAGVRWSVDTDRANQDLPGLPCSALDATQYNTSVGNVADNPCAGAAATTSLLGLYGSQFAGQVHQPYGNFAPQLGLAYALPDHVTVLRAGIGIFFEGDVFNNTTNARGALLKAGPFFAEAANGNVCGPGQFTNPDGSITNSATVGGQTMTIAQACAAPVKQAAPFILALSQGYQTASAKNPVSPNTSFIGETLNATGVYGAPYRTPYSEQWNFGLQRELFKGAVLSVDYVHNSTLKVAQEQDVNHVGAARYLNTTAATNAIAATLAPNAAAKYAGYPTCPQGSSAASINCAIANGATIDTFAQHGLDSGQAYLGGASAANNGDSIANGAAFPGANAKLGSGAFLLPVGRSGYDALQVVFREQKSHPVRGIERSNVQISYNLSRVVSSSFGGSDQFFSNSSWDNDNPNAYIGRAGLDRKHQVSFGGSFLVKHGPEVGVIGHFYSALPTSLTLDNTASSVGNIFQSDLTGDGTTGDLAPGTLPGDYMHRVKPGQLGAYINNFNQVYAGQLTPAGKALVAAGIFNSNQLTALNGVIQSLPTLPQAVAPANPMFRQVDVTFSYPIRIGRYVHTLGDSVLLEPKIAFYNVGNFSNYGNDGGNPNVAPFGGDLGTPGVGSVNGPNDFYSVDSQRVTRQSGTYDQGAPRTTEFQLRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q8</accession>
    <name>E8X5Q8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type VI secretion system Vgr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3996</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70792">
        <property type="protein sequence ID" value="ADW70792"/>
        <property type="gene ID" value="AciX9_3996"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3996"/>
    <dbReference type="HOGENOM" id="CLU_004121_7_3_0"/>
    <dbReference type="OMA" id="NTHTIES"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="391"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="678" mass="74399" checksum="27E8A50838BEC14D" modified="2011-04-05" version="1">MKFTSPLGPDELVIETLEGTEGISRLFEFQGELLADAGTEIELSAIMGQKVTVEISLVETQGSRYINGMVNGFVQMGGDTDFDVYHVHIVPSLWQLTLATNCRVFQGKTVMDIIKAVITPYGLSVGDKTEGTLQALDYCTQYNETDFNFISRLAEQHGIFYWFEHSDSDNKVNFGNSRTAYADCPLVNTVTYSPNSDVSQDRYVSSIQNFSSTATMVTGRHITGDYDYRTFDPNKVDGVPTTSTFANNTFSNYYWPGGEEGYVKLETKQLSTPQHAKGFLANRAGASDLEAEVLHGVSSARTMTSGYTFTMTDHTNDAWNRKYLLTEISHQVDQIPSYRSTTGGDDGEYRNRFTAVSSDLVFRPRLVTPKPLIHGPQTAFVVTAKGEDIHIDKLGRVCVQFWWDYQRPDGNTIDNTWVRVAQSWAGNGWGTYFWPRTEDEVIVQFLNGDPDNPIIVGSVYNGTNVPKYALPDMSTRSGILTRSSQGGGAANANELRFEDKMGSEQIFINAEHDMDHRIENDHREYVKNLKSVMVDGSHYDQTGGDRHSTLNANKVEKIKEKMSLDVGTDRNEKVGGNVSLQVGTNMAEKVGMNYSMDAGMEVYIKAGMTLVIESGMELCLKGAGGFITIGPAGIAISGTMVMINSGGAAVSGTAGTIVDPDPPTAPDQADDGTKGGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X626</accession>
    <name>E8X626_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_4130</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
            <plasmid evidence="12">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70910">
        <property type="protein sequence ID" value="ADW70910"/>
        <property type="gene ID" value="AciX9_4130"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4130"/>
    <dbReference type="HOGENOM" id="CLU_052646_3_0_0"/>
    <dbReference type="OMA" id="MWIDITS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="10">
        <location>
            <begin position="233"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="34945" checksum="3A9CB0B502FB5FEA" modified="2011-04-05" version="1">MKTIQGKSSPHAMSANSTVLPCNFRSAGRLSNESARTLTTVHETLARNLTNSLDVYLGTGLEVRLIHLEQFSMEDFKATCMSAAYMLPCSAKPSSNTLLLEMDSSLMFTVIDLLLGGSGKNPESARELTEIDEEIMEGVGSLIAQQIERAWQPVGFVLTPGKCVKPNLAHRVFPPTEKVLRIHFEVSVAGVTGALYIAFQASMASHLVRNIRADSTGKTGGVVYMPLPKLQKRILDCQFALSGDIPNLKVPVRDLARIEVGSVLMLSAPVSMPGKLTLEGKTYYEALPVRQGNNKAMQLMNAIHSKHTDVEAKEEEHHAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N5</accession>
    <name>E8X6N5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3909</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582203.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71185">
        <property type="protein sequence ID" value="ADW71185"/>
        <property type="gene ID" value="AciX9_3909"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3909"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="NYEFFGD"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="25455" checksum="A38D32C4BB053716" modified="2011-04-05" version="1">MRVLIVEDELRLAENVAEALRQGPGFAVDHAEDGEAAIHLAANACYDLIILDLNLPKMDGPAVLHRLRATGDKTPTLILTARAERESIVALLNAGADDYLTKPFDLGELIARAKALIRRSTGVAAPSIRLGELEVDTLQQTVSRAGTLIPLSPMEYRILEYLIHRPRIIVSKRQLLEHMYDFNWEHHSNVIEAHLSNLRRKLDPSGSEPVIETLRGRGYRLLAGPQGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R3</accession>
    <name>E8X6R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3937</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582231.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71213">
        <property type="protein sequence ID" value="ADW71213"/>
        <property type="gene ID" value="AciX9_3937"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3937"/>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_0"/>
    <dbReference type="OMA" id="QCARDSN"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234458" evidence="3">
        <location>
            <begin position="19"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="469"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="892" mass="96273" checksum="E13BF37AA279605F" modified="2011-04-05" version="1">MRFISAALILLAATAASAQNGPQNSHQDAKPLPYMDPALTTQQRVDDLVSRMTLEEKVSQTINSAPAISRLNVPEYDYWSEGLHGIARSGYATMFPQAIGMAATWDAPLLQQIGDVISIEARAKFNEAIRHNIHSIYYGLTIWSPNINIFRDPRWGRGQETYGEDPFLTGRLGVAFVKGIQGPDPNYFRAIATPKHFAVHSGPESTRHSANIEPTPHDLHDTYLPAFRATITEAHADSIMCAYNAVEGSPACASKLLLQDTLRRDWGFKGFVTSDCGAIDDFYATDYPSHHTSPDKEAAAAAGIKAGTDSNCGQTYLTLGSAVKKGLVTEAEIDTALKHLFTARFQLGLFDPAAKVAFNAIPFSEVNSPAHQALALKAAEESIVLLKNDAHTLPFKPSVRTIAVIGPSAATLNNLEGNYNAIPLHPVLPLDGILTQFKSSKVLYAQGSSFADGVAIAVPRTVFHLDMTSPEQGLKAEYFATDSFDGTPVATRIDKQIDFDWNSASPIPGAPAEAFAVRWSGTIAMQAPGAYDFQLLLTHCYPCNDHERFDVYLDGKSVGDFAAANNEYRPIGKFTLNLPDTARHALRVEYRHKAHLFGAGITLAWVPKPGALLPEAVAAAKKADVVVAFLGLSPELEGEEMPIHIEGFAGGDRTDIKLPAAQQQMLEAVAATGKPLVVVLLNGSALAVNWANDHAAAILEAWYPGQAGGTAIAETLAGKNNPAGRLPVTFYSSIDQIPAFDDYSMANRTYRYSKAKPLFEFGYGLSYTTFTYSNIKLSTQTLHAGDPLTVEADVRNTGRVAGDEVAELYLTPPHTAVSPQRALSAFTRVHLAPGELRHVTFTLDPRTLSQVDEKGARAVTPGNYTLSVSGTQPTSQTPAIPFTINGIQPLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W9</accession>
    <name>E8X6W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3792</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71078">
        <property type="protein sequence ID" value="ADW71078"/>
        <property type="gene ID" value="AciX9_3792"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3792"/>
    <dbReference type="HOGENOM" id="CLU_1813068_0_0_0"/>
    <dbReference type="OMA" id="EAEYHAT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234464" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="14901" checksum="1AF10DAF681BFF4C" modified="2011-04-05" version="1">MKRLIPALALALASSFVAAQTGGITVWSKGMPPDGIKGKAEFGDHELSISHREKDGRAELHKTKADVMVIQSGTATLVSGGEVIDPVPTAPNEIQGSGIRNGTKRTVGPGDVIEIPIGVPHQFFLAPGTQITYVVVKVVKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X719</accession>
    <name>E8X719_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3842</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582150.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71128">
        <property type="protein sequence ID" value="ADW71128"/>
        <property type="gene ID" value="AciX9_3842"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3842"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OMA" id="LIHYYLM"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="27724" checksum="3C353462B366D20D" modified="2011-04-05" version="1">MDLDLRGRVVIVTGGGAGIGEAITRALLDEGAKVVAVGRMGENEQRFAAEMKVSGAACDFVEASLAEAEQCKRVVEFTRSTHGRLDGLVNNAGANDSVGLASGDPTRFFESLRQNLVHYYSMAHYALPMLREAKGAIVNISSKVALTGQGGTSAYAAAKGAQLALTREWAAELLPVGIRVNSVLPAEVLTPLYQRWLDTRADPVAALRHITERIPLGRRMTEGAEIAATTVFLLSAKQSGHTTAQHLVVDGGYTHLDRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M6</accession>
    <name>E8X7M6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4519</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573179.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4519"/>
    <dbReference type="EnsemblBacteria" id="ADW71460">
        <property type="protein sequence ID" value="ADW71460"/>
        <property type="gene ID" value="AciX9_4519"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4519"/>
    <dbReference type="HOGENOM" id="CLU_1710697_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="16415" checksum="DC1BE787A6CDC99F" modified="2011-04-05" version="1">MTQIILALRSGPIKDSIVASCAIQGDPTGLRGSSKQFANVRELEDALDLALVTTRKIGFALMVVNSGHPSFIELSELEAYSLGVLETAGLLKLLVDDEADLKQKLELLEATFTSIRDHRGADGWTRGEADFGQGRIVDLRIFLSSLSKGGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q2</accession>
    <name>E8X7Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4551</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71486">
        <property type="protein sequence ID" value="ADW71486"/>
        <property type="gene ID" value="AciX9_4551"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4551"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2861462_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7325" checksum="4261698DE04B25EC" modified="2011-04-05" version="1">MDYNVCAGHLQPIIQQSRESNKRELVIPRWGLVAFYTKELSDIKDPSTIKTRAESTTKDPTYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X2</accession>
    <name>E8X7X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573275.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71556">
        <property type="protein sequence ID" value="ADW71556"/>
        <property type="gene ID" value="AciX9_4626"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4626"/>
    <dbReference type="HOGENOM" id="CLU_174532_0_0_0"/>
    <dbReference type="OrthoDB" id="1981428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11012" checksum="B00AB7497C8257B5" modified="2011-04-05" version="1">MPLLSIQASKKVETTVRLEESTAKRVDQYAHFAKASADDVVNQALEYVFTKDKDFQQYLTQHQGGETPAALRIKKPAATIASKNNGAGNGATNGAIPHAVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X820</accession>
    <name>E8X820_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4675</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573322.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71604">
        <property type="protein sequence ID" value="ADW71604"/>
        <property type="gene ID" value="AciX9_4675"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4675"/>
    <dbReference type="HOGENOM" id="CLU_1872535_0_0_0"/>
    <dbReference type="OrthoDB" id="2054858at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025459">
        <property type="entry name" value="DUF4279"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14106">
        <property type="entry name" value="DUF4279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="15069" checksum="4AC674FE43439DD0" modified="2011-04-05" version="1">MSHKYTVEFRIYGKSLDPAAVTADLGLEPCRTVNPGTRRADGRLLEGLWAFDGDPSEAFSGSLEEALRFVLDLLHPLKERILAYRTSAHLVWWCGHFQSSFDGGYTLSAAVLGQLSDFGVEFTVDNYFSESEATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV92</accession>
    <name>E8WV92_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0193</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578595.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0193"/>
    <dbReference type="EnsemblBacteria" id="ADW67267">
        <property type="protein sequence ID" value="ADW67267"/>
        <property type="gene ID" value="AciX9_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0193"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_0"/>
    <dbReference type="OMA" id="GITGQFI"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="25592" checksum="3CA14659B8CD7E06" modified="2011-04-05" version="1">MSETPRLLLFGASGAIGTAILNHCSEKGWQVTAVSRKRPEAVMAALTWIEADPLSPTFDASILATNAPYTSVCWAQGANSTDSVYTVEAEAHLDLYKANCLYILLTLKALLDYDLLAPASRLCVISSIWQNLARQSKLSYCMTKAALQGLVLSASVDLAEHGHLINAVLPGVLDTPMTRRNLAPEQLEKLSGATKFNALPQLQDVANLVEFLCSTWNTGITGQFIAADLGYSHVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI1</accession>
    <name>E8WVI1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1369</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579751.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1369"/>
    <dbReference type="EnsemblBacteria" id="ADW68429">
        <property type="protein sequence ID" value="ADW68429"/>
        <property type="gene ID" value="AciX9_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1369"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023239_0_0_0"/>
    <dbReference type="OMA" id="AYWHSAS"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234080" evidence="2">
        <location>
            <begin position="31"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="623" mass="66901" checksum="70C2F97581377D4E" modified="2011-04-05" version="1">MIHKQAITRRLSTLALAAAATLISMAPTYAQDHPAEAPAALPPGMTGSTLNDPRVGLKPGLYDAGEAASGMQHLAFLKKASAFQLGATGPDDPIVQKTLNTLGAAGVPAPMRMVIAQLAYANSDFAFQGTHLIQGNFSGVSFYDIANPAKPALISTLVCPGGQGDVSVYNNLLFMSVEMPNGRIDCGAQGFPPNPPPAPGHEKEHHPPVASPDRFRGVRIFDISDLKNPKQVAAVQTCRGSHTHTLVVDPNDKNNVYLYVSGTSFVRQSEELAGCSDEAPEKDPNTSLFRIDVIKVPLSTPQEAKVVASPRVFVDPRTGALNGLNNGGSHGEEKVADTNQCHDITVYSAIGLAAGACSGNGILIDIKDPVHPKRVDAVNDPNYAYWHSASFSNDGTKVVFTDEWGGGLQPRCRTTDPLKWGADAIFNLKDDKLSLAGYYKMPAAQTETENCVAHNGSLVPVPGRDIEVQSWYQGGISVMDFTDPAHAFEIAYFDRGPIDPKSVVLGGDWSAYWYNGNIYGSEIARGLDVFKLTPSKFLTQNEIDAANLIHYKELNVQNQQQVIWPSQLIVAKAYLDQLTRTQALPADRLATLTKAVDKTQKSHLNKKGSSVHLVILSSGSLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM4</accession>
    <name>E8WVM4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2523</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2523"/>
    <dbReference type="EnsemblBacteria" id="ADW69553">
        <property type="protein sequence ID" value="ADW69553"/>
        <property type="gene ID" value="AciX9_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2523"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_0"/>
    <dbReference type="OMA" id="LSTMDHC"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="32"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="610"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="814" mass="92092" checksum="FB151C5483C83357" modified="2011-04-05" version="1">MPTDMLTTEDLLHETSDAIAAEESLKGGATLTPDLLRRMNAYWRAANYVSVGQIYLYENPLLREPLKLEHVKPLVVSHWGTTPGQNFIYVHLNRIIKKYDLNMFYIAGPGHGGPAIVGNVYLEGTWSEVYPNVTQDEAGLKKLFKQFSFPGGISSHVAPTTPGSIHEGGELGYSLSHAFGAAFDNPDLIVACVIGDGEAETASLATSWQSNKFLDPRTDGAVLPILHLNGYKISNPTVLARVEHEELDQFLRGCGWTPYFVEGDEPEKMHELMATTIDVAIEDIHRFQSNARTGNDTTRPRWPMIVLKSPKGWTGPKVVDGLQIEGTFRSHQVPLLVDPAHPDHVKLLEAWMKSYKAEELFDENGRLLAELAELAPKGDRRMGANPHANGGILLRDLDMPDFHDHAVTVNSPGAVEVEDTLVLGSFLRDVAKLNQDKRNFRVFGPDETVSNLLQAVFEVTNRQWDAREYSNDEFLAPEGRVLDSMLSENQCEGWLEGYLLTGRHGLFNSYEAFIRIVDSMFSQHAKWLKVCRELPWRRDISSLNYLLASHVWQQDHNGFTHQDPGFLDHVINKKADIVRCYLPADANCLLSVFDHCLRSRNYVNVVVAGKHALPQWLTMDQAVVHCTEGVGIWQWASNDQENEPDVVMGCCGDTPTLEILAAVSILREHLPELKIRVVNVVDLMKLQPSTEHPHGLTERDYDSLFTKDKHIIFGFHGYPWLIHRLTYARTNRNLHVRGYKEEGTITTPFDMRVQNDLDRFHLVMDVVDRVPNLGSKGDYLKQQMKDKLIEHKHYIDAHGEDMPEIRNWKWSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU4</accession>
    <name>E8WVU4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate 2-dehydrogenase (Acceptor)</fullName>
            <ecNumber evidence="3">1.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3702</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.99.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3702"/>
    <dbReference type="EnsemblBacteria" id="ADW70703">
        <property type="protein sequence ID" value="ADW70703"/>
        <property type="gene ID" value="AciX9_3702"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3702"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_0_0"/>
    <dbReference type="OMA" id="QTQGYVR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033717">
        <property type="term" value="F:gluconate 2-dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="198"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="408"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="517" mass="55707" checksum="81DF90E71629CF7A" modified="2011-04-05" version="1">MKSFSTNDVVDVVVIGTGAGGAPVMATLAEAGLSVVALEAGRWWDPAKDFAADEVQMSELYWLDERISAGETPTAFGGNNSGTGVGGSMLHWGAYAPRADERDLKLKTDSGLGVDFPLDYAELKPIYEELDRFMGVSGPTPYPWNESRQFPLGPIALNAPALAMQKGFAALGIRTAEAPIAAVSAKYTQPGYAERQPCVGCGFCHQGCVFNGAKGSMDVTWLPRALAAGVEIRPDSFVHQIELDAKGEVSAVVYRTKSEDHRQRCKAVFLCAGAVETPRLLLHTGLANSSGQVGRNFMAHVATQAWGTFAPEMRMNKGFPASLISEEMMRPADADFVGGYLVQPLGVVPVTFAKQVARGRGLWGQALVDYLDQYNHIAGIGINGDCLPYNGNYLELSDEADQRDGIGMPKPLIHFSYGENEKRMSEHGAKLMTSAWEAAGATDIWTFERSAHTIGTCRMGDDPKDNVVDAYGRSHDIPNLWISDNSTFPAALAANPAMTIMALALRSARQFLSLTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ6</accession>
    <name>E8WVZ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3755</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582063.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3755"/>
    <dbReference type="EnsemblBacteria" id="ADW70755">
        <property type="protein sequence ID" value="ADW70755"/>
        <property type="gene ID" value="AciX9_3755"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3755"/>
    <dbReference type="eggNOG" id="ENOG502ZC7R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041811_0_0_0"/>
    <dbReference type="OMA" id="FEFFINV"/>
    <dbReference type="OrthoDB" id="1143035at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="28526" checksum="9E32D4247FC17A48" modified="2011-04-05" version="1">MAEVGQSGLVKATDAAQAMTLQHAANGIVYAHAGETQLVETDLARLVQAVPAPIAAALKDKSYYFVPLALAEPRRDGHRGTEETLVSPIYTAALGDEAICHRNVTLPSAPDGSAREGVFISVRLLNDRFALSFEFFINVGHAFVDAAGVPAEFTDLIWAQAIADIRGETSQDSWESRTAALADRNHPDEKAKLEFSEAAFSDALAIYQLSLAVDFDYSELREREYPLLAPTALAERLKLVAKLFPPNKDYEFSIRYRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW58</accession>
    <name>E8WW58_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0502 protein AciX9_0292</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0502 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578692.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0292"/>
    <dbReference type="EnsemblBacteria" id="ADW67364">
        <property type="protein sequence ID" value="ADW67364"/>
        <property type="gene ID" value="AciX9_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0292"/>
    <dbReference type="eggNOG" id="COG3132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057831_1_0_0"/>
    <dbReference type="OMA" id="CNQKSSR"/>
    <dbReference type="OrthoDB" id="1721848at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01584">
        <property type="entry name" value="UPF0502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007432">
        <property type="entry name" value="DUF480"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38768">
        <property type="entry name" value="PTHR38768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04337">
        <property type="entry name" value="DUF480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="22972" checksum="11F2463B10AEB0A4" modified="2011-04-05" version="1">MADALKLTPESLRVLGALMEKEMTTPENYPLSLNALIGACNQKTSREPVMEFTEDAVRGALDALEIHELISTAHDSRVPKYEHRIRTVLNLRRDETAVLCLLILRGPQTTGELRGRSDRMFSFDDTIQVQSTLDRLAARETPLVAVLPRQPGSSASRSAHLLGDVAQTYAAAAAPAAPNELSVLRERLAELELRVAALESMQHPAHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW80</accession>
    <name>E8WW80_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1405</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579785.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68463">
        <property type="protein sequence ID" value="ADW68463"/>
        <property type="gene ID" value="AciX9_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1405"/>
    <dbReference type="HOGENOM" id="CLU_2382087_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10544" checksum="F5A0A93A666D2147" modified="2011-04-05" version="1">MTYIATVDHEGQIKLPQEILEHLGVSANVQVELEATEGAVKVSRRLAGEATMSLENRLKRAKDAIEKYGGPVREQFLAEGWKSVDEYIDDMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD2</accession>
    <name>E8WWD2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579835.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1462"/>
    <dbReference type="EnsemblBacteria" id="ADW68515">
        <property type="protein sequence ID" value="ADW68515"/>
        <property type="gene ID" value="AciX9_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1462"/>
    <dbReference type="HOGENOM" id="CLU_477158_0_0_0"/>
    <dbReference type="OMA" id="YFRSYWI"/>
    <dbReference type="OrthoDB" id="2106714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230373" evidence="2">
        <location>
            <begin position="24"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="571" mass="61994" checksum="11BAC20FF374B206" modified="2011-04-05" version="1">MRSLRIPLISFLLLILCGGAVYAALQSSAPGPAPLASYAPPGALLAIESPDFASVLAAWTHSSERKRWLAGDNYAGFSRSRLFDRLSQAQDEFATTAGLPPDSNFLQQIAGRQSLLAWYDIGNLEFLYITRLPPGDAAKTPLLQLRDRFEQRKAGDATFFVRTQQEPARTVAFAVQGDYLLLATREDLLAGALELLQHPAAATSRTLLNDTWYATTIAAASKTPGDLRMTLNLAKIVRSPYFRSYWIQQNVSETKQYIAALSDLYRSPDALREERVLIPADPDTQPQTSDLSSVLDLVPPGLGVYRAQSAPTTADILTQFEDKLLSRRPTEHSDTHIAPQADLSTPESGTSTNLEQRIDEPTLPAQPREQALTALRTLFSSATPTSLLSFSTVDPAPSTFTPIHTAVALTAAAPWSPTTLQQALTAALLPRLSSPGTSLQWTQRDEGGSSSYSLEGPQSLTFALIGNTCVLASDYPTLHQLLSAQRTATHSPRIASTIAGFSHRAERPPFLHLTATLDHSASPSAGTTPAFFSRNLASLSQTFVDLDSESFTQAPAKDGATRQTVLYQWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF0</accession>
    <name>E8WWF0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal peptide peptidase SppA, 36K type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2589</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580929.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2589"/>
    <dbReference type="MEROPS" id="S49.A08"/>
    <dbReference type="EnsemblBacteria" id="ADW69614">
        <property type="protein sequence ID" value="ADW69614"/>
        <property type="gene ID" value="AciX9_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2589"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046540_0_0_0"/>
    <dbReference type="OMA" id="VKYYAVW"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="157"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37583" checksum="AA9973E10D45CBF6" modified="2011-04-05" version="1">MPDDLNQAPPPPQPPYVPQNQASAFPPQQPAFGSPYGNAGGYANPYGYPARPPRSAWFWPSIILGSIVVVVGLFGAIVWSAAKSLGGDTTATTTFATSEIAVIDIDGVILDADKVDSQLRKFGDDSSVKAIILHINSPGGGAAASQEIYHEVLRVRQEKHKKIVASVESVGASGAYYIASACDKIYANQASVVGSIGVIMEWTNYGDLMKWAKLKPVVIHAGELKDAGDPSRDMTPKEAAYFQALTDNMYGQFVRDVAAGRHTSTEKIQPLATGQVWTGEQSLPLGLIDKIGGFRVALMDTAHDVGISGEPAIVKPNSAKKGLAGLLSGEGDDLFPNPTKLLDHAPGFYFMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI4</accession>
    <name>E8WWI4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2623</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580963.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2623"/>
    <dbReference type="EnsemblBacteria" id="ADW69648">
        <property type="protein sequence ID" value="ADW69648"/>
        <property type="gene ID" value="AciX9_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2623"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753902_0_0_0"/>
    <dbReference type="OMA" id="ADHAMTE"/>
    <dbReference type="OrthoDB" id="1927508at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233923" evidence="1">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="367" mass="39432" checksum="63C3407D0F99A1F6" modified="2011-04-05" version="1">MRARSLIGLVVLFAAIGAGGQTSVPGAPEVGTAGDAALPTLHVYTNLIQIPTLVLSPLRGSMGRVAEDRFLMSVDSGPLFKPTHVREEGNDPISLVVLLDPSGEASGLMDEVRQRLARLAPGQLQARDSISMYVMSCGLMRTGLNVPVDRASLQMAADHAMTEVKRVQGRHGCRQGVGLWDAMAMTVKQASKLPGRRVMLVVSDGQDRGSRTKWPEVREYAQSQGIAVFGLSTTGSIPNSLSGRGSGRSALPGYTSTETNEDAFNELCELTGGMRLYAQEIEVGSELKRLVKLLRERYIVEFPRSTGIGAGKHDLVVTISRMNAFVRPAGISVPLPDPKILADPMTLPNDLTKEPVGGERRILVPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA4</accession>
    <name>E8WXA4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ordered locus">AciX9_2722</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581061.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2722"/>
    <dbReference type="EnsemblBacteria" id="ADW69746">
        <property type="protein sequence ID" value="ADW69746"/>
        <property type="gene ID" value="AciX9_2722"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2722"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_2_2_0"/>
    <dbReference type="OMA" id="WRDTENF"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="16362" checksum="4C58AC48B4F8686F" modified="2011-04-05" version="1">MFRGNHPARVDEKGRLKIPADFKREFPEKQEFYVTSLDGKRAQLYPIAEWEKKEEVLAKMPSTSVAKIKFLDVTSYYGQMVEMDTQGRVLLPQILRESARVDGEVVVLGKQGILEVVNHDDFKAEMVKAPLSMQDMAALAEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD6</accession>
    <name>E8WXD6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578797.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0397"/>
    <dbReference type="EnsemblBacteria" id="ADW67469">
        <property type="protein sequence ID" value="ADW67469"/>
        <property type="gene ID" value="AciX9_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0397"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_8_2_0"/>
    <dbReference type="OMA" id="VWARLMA"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="15011" checksum="B269D9B160384AEB" modified="2011-04-05" version="1">MLYLLDTDILSQRTKPFPNPQVKAWLAATNDLDTAISVINLLELQQGVGVLPTGKRKKSLEHWLSVSILEIYENRILPISPEIALHAGNLVALAKSSGHTATAEDALIAATAHIHALTLVTLNRKHFQRLGAKMLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK5</accession>
    <name>E8WXK5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1568</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1568"/>
    <dbReference type="EnsemblBacteria" id="ADW68621">
        <property type="protein sequence ID" value="ADW68621"/>
        <property type="gene ID" value="AciX9_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1568"/>
    <dbReference type="eggNOG" id="COG5267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026001_0_1_0"/>
    <dbReference type="OMA" id="LDNWQSV"/>
    <dbReference type="OrthoDB" id="637794at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233469" evidence="1">
        <location>
            <begin position="29"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="708" mass="75997" checksum="E97E67EFD0FBC2DF" modified="2011-04-05" version="1">MTVDLKALGRMTLAVSLCGLLAGEPLVAAVPAGTELRGDARVLHALNRFTFGPRPGDVTAVKAMGLKRWFDLQLEPGKIDDSALDARLAQFPAMGLSVGELMSRYPGPQAIRAMEAGRRALPSDPTARVIATDEVAFYKMQKAQKAGKETLKQAAAEPVDADGMMAAGQLAPGQTAGDKPLAANEVSAAEPMMDGPVAGGMSHEAVMAIVNQPPAQRYDSLLALPAGDLVSLRRGMKPRELLQLVDGLTPVQKETLQALPGAVRMVALESMESRLERDIYSDRQLEAVMTDFWLNHFNVYLRKNQQEPYLIPTYERETIRPHALGSFEDLLVATAKSPAMLMYLDNWRSTGPDSQAAARIKRIQQMRPNGPIAKNASAGLNENYGRELMELHTLGVGGGYSQADVTQVAKVFTGWTIDKPYGQAEDGAGGFVFDGRRHEPGAKVVMGQTIKEGGEKEGLEVLHMLATSPATARFISTKLAVRFVSDAPPQALIDRMTTSFLASHGDIKTVLRTMFDAPEFWAPDVERAKVKTPLEFVVSAVRAGGVEVNNAQPLVKALDKLGMPLYGMQTPNGYSWMKDGWVSTGALVSRMNFALVLTDDRMPGARTEWGRLLGGVQNVSYEADAKERRLEGILLGFAVSEKTRAAVLSQSKDGGIADQAAAQFDLSGGGKKGAGKGLRVMAGGGSPDDAQAAVMAGLLLGSPEFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL3</accession>
    <name>E8WXL3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">carB</name>
        <name evidence="17" type="ordered locus">AciX9_1576</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579948.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1576"/>
    <dbReference type="EnsemblBacteria" id="ADW68629">
        <property type="protein sequence ID" value="ADW68629"/>
        <property type="gene ID" value="AciX9_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1576"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_0"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="143"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="689"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="953"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="953"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="851"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW68629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1099" mass="119270" checksum="858E6CA79E1A85CD" modified="2011-04-05" version="1">MPRRNDIAKILVIGSGPIVIGQSAEFDYSGTQACKALKAEGYEVVLVNSNPASIMTDPEVADRTYIEPLTTTYVEEILRVEVEMLAASGKKGVFAVLPTVGGQTALNLAVDLADSGVLEKYGVELIGAKLEAIKKAEDRLLFKDAMNKIGLDMPKSQLVNNVSDGLAFAGKIGFPAVIRPSFTLGGSGGGIAYNRQEMTEILSRGIDLSPVSECLIEESVLGWKEYELEVVRDLKDNVIIICSIENFDPMGVHTGDSITVAPAQTLTDREYQAMRDAAIAVIREIGVETGGSNVQFAVNPQNGRMTVIEMNPRVSRSSALASKATGFPIAKIAARLAVGYTLDELQNDITKATPACFEPTIDYVVVKIPKWQFEKFPGADENLSVQMKSVGEVMAIGRTFKEAMMKAVRSLETGKKATADDIEPRRLTQRLVTPHPERLSYVRYAFERGMTVREVSRMTGMDPWFLHQMKQITDEIKAIGSATMETVTAEELRAAKRMGISDERLAAGWGLTGAEGTAAVRALRKKLNVMPVYKMVDTCAGEFESFTPYLYSCYDEEDEAAPTGKKKILILGSGPNRIGQGIEFDYCCCHAAFALREDGYETIMVNCNPETVSTDYDTSDRLYFEPLTLEDVLGVYEHEAQSGAEIGMIVQFGGQTPLNLSLPLKKAGVPIIGTSPESIDLAEDRKRFGKLIEELEIPQPEGALATSVAEAVAGANRVGYPVLVRPSYVLGGRAMVIAYDDEAVIKYMSTAIEYSQERPVLIDHFLEDATECDVDALCDGDDVVIAGIMQHIEEAGIHSGDSSCVLPSVDLTDEVKETIRTYTRALAKALDVIGLVNIQFAIQRGKVFVIEVNPRASRTVPYVSKATGVPLAKIASRIMVGRKLKELLPEYVASGQDLGTGSHYFVKSPVFPWGKFPGVDTVLGPEMKSTGEVMGVADNFGEAFAKAQIAAGQVLPMQGTVFLSVNDHDKDGAVKLARQFVEMGFHLVATHGTAAVLEEAGLQPERVFKVKEGRPNVVDLIKGDRIQMIINTPRGQDTFFDEKAIRRAAVLARIPTITTLAAARAAAEGIQSLQSGELSVVALQELHACRVMETAQALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN0</accession>
    <name>E8WXN0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hopanoid biosynthesis associated radical SAM protein HpnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1593</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579965.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1593"/>
    <dbReference type="EnsemblBacteria" id="ADW68646">
        <property type="protein sequence ID" value="ADW68646"/>
        <property type="gene ID" value="AciX9_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1593"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052502_0_0_0"/>
    <dbReference type="OMA" id="FNTDTPQ"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="378" mass="42063" checksum="4713CC6D310D9771" modified="2011-04-05" version="1">MAVPISQAWTVATYVLKQKFAGRKKYPLVLMLEPLFRCNLACAGCGKIQYPAHILKAELSPEDCFRAVDECGTPMVAIPGGEPLLHPQMPEIVAGLVARKKYVYMCTNALLLKEKLHLFKPSKYLSFSVHMDGQREHHDFSVCREGGYDIAMEGVRVAVEAGFRVTTNTTLFDGADPNSVRAHFDELMVAGVESMMVSPGYTYDKAPDQNHFLGRAKSRKMFRAILSNRKKSWRFNASPMFMEFLMGKKDLTCTPWGMPTFSIFGWQKPCYLLQDGYADSFKELMETVEWENYGTESGNPRCANCMVHSGYEASGVNYTFGSIKGLLQTAKAMFSSYKDDGASRILNDWKPAQHGPLVQIGSAQTAAQASELQSVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP1</accession>
    <name>E8WXP1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1604</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1604"/>
    <dbReference type="EnsemblBacteria" id="ADW68657">
        <property type="protein sequence ID" value="ADW68657"/>
        <property type="gene ID" value="AciX9_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1604"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645237_0_0_0"/>
    <dbReference type="OMA" id="ISAGWHI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="281"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="425" mass="47110" checksum="0809A5044720C520" modified="2011-04-05" version="1">MNDRQFENLPYLVVSATLIATLLILQRRLPRLAINSWIFALGFTVISEISGYFIEISAGWHIAMHTVRLCSDLLAGVAFLFFTGRKLSATSDHDFKLLWNAVPFFALELIFGLEVFTPWPYVLCAAAGAVISVAVAVLRKRSSIIPVAQVILWFAIATFAVLGNYRASAYWGLGGVFAAAGLHLWYRLPRNTIGRVALVLSLFVWSASFFTHSYVFPHPKLRMMAENIWSIQKFIVSVSMLLILLESEARENEALAMRDQLTGLANRRLMELRLTSAISTGHTSILLLDLNGFKQINDTHGHLAGDELLQQIAERLTQCVTEEETLARLGGDEFLIISNRDILTLNGSVQEALSKPILLGRNLTIVVNASIGTAIFPLDAQGSSGAEAITNLLRVADNQLYARKQAHTVEEATVTNPRRLYRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ3</accession>
    <name>E8WXQ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-Ig-H3/fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2724</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581063.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2724"/>
    <dbReference type="EnsemblBacteria" id="ADW69748">
        <property type="protein sequence ID" value="ADW69748"/>
        <property type="gene ID" value="AciX9_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2724"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_4_1_0"/>
    <dbReference type="OMA" id="YPSKNIV"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233471" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="19444" checksum="79109152D11BF0BB" modified="2011-04-05" version="1">MNLKKTFLASMAAAVLAATSFSAVAQKADPTVGGAAMYANKTIVQNAIASPIHTTLVAAVKAAGLVDTLSGPGPFTVFAPTDDAFAKLPAGTVDTLVKPENKDTLVKILTYHVVPGKIDSKKLAKDIKKGGGKTMLKTVQGEELTFMMPSPGMITITDAKGGVSNITTADVYQSNGVIHVIDTVLMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT1</accession>
    <name>E8WXT1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2752</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581091.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2752"/>
    <dbReference type="EnsemblBacteria" id="ADW69776">
        <property type="protein sequence ID" value="ADW69776"/>
        <property type="gene ID" value="AciX9_2752"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2752"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348378_0_0_0"/>
    <dbReference type="OMA" id="YSFAQYT"/>
    <dbReference type="OrthoDB" id="1482774at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230435" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="21891" checksum="86CD6D27CFB776EE" modified="2011-04-05" version="1">MKKTIFLGALMLSAAAGYAQESRQDVSISGFETINPTVHGNSVTLTPTHTTGVLASYRFLLTPKSALEVNYSFAQYTNYYQYSGNLTYNPIHTRQQEFSAAYVFGLNFKNFNPFVEAGPGVMFFSPIRDNGTDRLDAKRATGVGGLFGAGLAYEISPSFDIRAEYRGFFVKAPSFIDDFKTGRYEVLSMPTIGVAFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX2</accession>
    <name>E8WXX2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581132.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2794"/>
    <dbReference type="EnsemblBacteria" id="ADW69817">
        <property type="protein sequence ID" value="ADW69817"/>
        <property type="gene ID" value="AciX9_2794"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2794"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110659_1_1_0"/>
    <dbReference type="OMA" id="QIGGNWC"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234151" evidence="1">
        <location>
            <begin position="27"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17553" checksum="24FADA6F97D750E8" modified="2011-04-05" version="1">MKHLSTFASLALALTLTAIPTFRAQAQAPGRRHIYSETANPVADVNAAIAKAKAEHKRVLIDAGGDWCGDCQVLDIYFRQQPNEALLDKNFVVVHIYTDSELGVNKAAAAKYGIPINKGVPALSVLDGNGKIIHSQQTGEFNDMRHMDSPSVTEFLNHWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY25</accession>
    <name>E8WY25_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0492</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0492"/>
    <dbReference type="EnsemblBacteria" id="ADW67564">
        <property type="protein sequence ID" value="ADW67564"/>
        <property type="gene ID" value="AciX9_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0492"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262617_0_0_0"/>
    <dbReference type="OMA" id="SHNIAFI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233974" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="802"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1286" mass="130656" checksum="9F676766DB81180B" modified="2011-04-05" version="1">MHSYKRVLLQAFIFLTACLCLPAFAESFTNPVRIVTPIDPDAVISGDLNGDGRRDLIWFKVVNGATTGHVLLAGPNNSFQPGQDFSFPANINVSRAPMCVTADVTRDARLDLICANYDPNTHIGSVFVFPGNGDGTLGAASVNKLSNQISDAVILASVGDLNGDGVSDFLLEQPYNSFVLVLLSDGKGGFLPSKTVVGNVAFSVPVIADINGDGIPDILWRDGLAVSLGKGDGSFGPLITSYTYTSPPGGGTCAFHDMDQDGKLDAVCGYPTSGNGGTTLDILHGNGDGTFNTTPIFHLPFGSTSVSGSGAGTFLYPELVADVNGDGIPDILAYSGDGLAVFLGAPGLSFGPPREYAIAAVGFAFLVDQAAQQQFVDLNGDGLMDLLSCGPNGLYLTYGHADGTFGTAPAPEVGVITGPTAMADFNRDGKQNLVATGSPQLTLNLGNGDGTFAPPISLQSSPVTSSSQIYAADFNGDGKPDLLANDSTYAPYLLFGHGDGTFATPQAATGIAAPLNTSNGSVGVVGDIDGDGKADLLLPSISSLSSTYSLVAALSLGNGTFRSVSTTYTAPVMPNGVSYYTPGTPILADLANRGKLDAAYILSTGLYVVQGHGNGSFDTTPSILPIPAHLGVAANGYSAVQSADFDGDGKPDLALVTEYQLPYSFSYQGVPSCVWIYYGKGDGTFIAPVQAGCFAHSYTSFKAADLNGDGLPDLVLQTASSLNTFAVGIVHSAAGRTFGPEICYTAGALSGDLFIKDLNGDGRPDLIFGNVASDAASSVTILLNQLDSGPVASATTLISSQNPSSPGTTVVFTATVKAGDASVPAGSMTFTDNSVALGTVPLIPGTASATTSVSEAPSTGTHTIVATYVPSGPLQASSASLIQIVSAPSTPSATQLTLQPVRTPAPALFGSYSFRSSLTSSQSSGSASVANQPVTITVQGFPPATLTTDNSGSIVYVTPFTLSAATYTVTAHFAGSTSLTQSDASTLQQIVPDQTSLILSAPATSPQGGAATITSTVTNLDGSASIAAANPSNGTITILDGGIAIATLTPGPTASLSAGVSFTTSQLASGLHTLTAVFTSKSGDITSASAGPVSLLITDPLFDLKVSSPTLSIQAEHHGNITATISSISGFNGLVNLTCSTPAGLLLTCEVGGDKRPSSASMQIASGGSVSLPVILDTDAVLDFKSALIPEPSRHNSATDVVWALLLPACGFGLLRCRLKAGRVNRLTLFVLLIAATLGLGVGLTGCSAKYPQHALVGSYDIVLTATSSSSVGAPVVRHITLQVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY45</accession>
    <name>E8WY45_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1619</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579991.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1619"/>
    <dbReference type="EnsemblBacteria" id="ADW68672">
        <property type="protein sequence ID" value="ADW68672"/>
        <property type="gene ID" value="AciX9_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1619"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="FRENDFP"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14961" checksum="449577260B2FBF3C" modified="2011-04-05" version="1">MDLNGTERVEEAKADETAILLIDDNAVQAATRQTILKRAGYFVIAALNPVRALEQFQANDFPAEIKLVITDHLMPGMTGSEFVGELRKSHPVLPVLVISGLEEAEEQYVGMNVMFRRKPLLPDHLLASVHSLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY65</accession>
    <name>E8WY65_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase HpnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580011.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1640"/>
    <dbReference type="EnsemblBacteria" id="ADW68692">
        <property type="protein sequence ID" value="ADW68692"/>
        <property type="gene ID" value="AciX9_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1640"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_0_1_0"/>
    <dbReference type="OMA" id="DYCRYSA"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="35086" checksum="54E52F3197F71314" modified="2011-04-05" version="1">MEATVFDLTGAPAEYAMPAVRPTLEEAQAWCRHLATSHYENFHVATWFLPKRIRPYFESIYAFSRTADDLGDEVADKDTATRLLTTWEQMLDECYEAPERSVHPVFVALRKTIDETQVPKQLFADLIHAFLQDQLMTHYESMEGLLGYSKLSANPVGRLVLWVSGYHDEERALLSDKVCTALQLINFWQDVVEDWERGRRYLPIAEMQRFGVVDCLIAERRFTPEFAAMMTYLAGYAGEMLKQGGAVSGTVDRELGVTLKLFVKGGEAALGGIVAQGYDVLRARPSVSKMTKMKLLGGALAGKLAGAVFGAGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH7</accession>
    <name>E8WYH7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2860"/>
    <dbReference type="EnsemblBacteria" id="ADW69883">
        <property type="protein sequence ID" value="ADW69883"/>
        <property type="gene ID" value="AciX9_2860"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2860"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_2_4_0"/>
    <dbReference type="OMA" id="EFHKGVD"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="230"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="36601" checksum="474BCD7DA5AECE71" modified="2011-04-05" version="1">MSSKKRFYILFVSRDEDGTIQKVPVPLRYAYVFVAAAAIGMFTITGMAGSYSRMLIKTARFNQLRHDQDTLRKDYASLEIQAKQKDVQAASLGALATEISSLYGMTANKLTAVRGGGGKIKDVAAKAPAPGTAPLKDAPAAMTYDAYYKSLDSFYALRTNAMSGDTARFLTGPSDVGRIRNPLMPGHDLFEGNALTAAAFAPTLWPVTGPITSSFGEREDPILGNGDGEFHPGLDISGPLGTPIHVTADGVVTSVDWVNGYGRLVEVDHGHGVRTRYGHMSGFAVTAGQTVSRGDVIGYIGHTGRTTGNHVHYEVRINGTAVNPHKYLRMTLAEFGSGTPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK3</accession>
    <name>E8WYK3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0529</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67601">
        <property type="protein sequence ID" value="ADW67601"/>
        <property type="gene ID" value="AciX9_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0529"/>
    <dbReference type="eggNOG" id="ENOG5033RCM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056494_0_0_0"/>
    <dbReference type="OMA" id="VKYEANI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230466" evidence="2">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="408" mass="41372" checksum="48EF92190B184DB0" modified="2011-04-05" version="1">MLAAVGAAGLLSGGAGAQQAPANSGTMLVMAPLPLLPQKLAGMTLAQTAAGVATDATAQEFSADCSALPMNPPPSAGGSGVTCAAVLKEDGLTRFASGSYARAAGAPVGVLALEFGDATGAYSAYTFYRSLMKAPRVTGGDARVGKAAETSSDADGSVAWAGTAIVRVTGRVAPNELTAIVSALPKVGGRRGIAPLLPTLLPEKGLEAATARYALGAAGYKAMNGVLPAEMLDWSKSTEAITAGYSAGGKGTVTLLMYPTPQIAGDRGRAVVKYINDTGPAQFGTVKMRRVGPLVGLTTGGLGATQAQELMTALHLSQDLSFDKPMPLEFHAEIRKTATLLQSIAIFCGIGTLAAIVLGVFLGGARAGIRVLQGKPAHSDPEFLTIDLRDKPKGFFAKKDEPKSGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM7</accession>
    <name>E8WYM7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0553"/>
    <dbReference type="EnsemblBacteria" id="ADW67625">
        <property type="protein sequence ID" value="ADW67625"/>
        <property type="gene ID" value="AciX9_0553"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0553"/>
    <dbReference type="HOGENOM" id="CLU_202662_0_0_0"/>
    <dbReference type="OMA" id="ARKPKHK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="55" mass="6174" checksum="4BF07DCB2FD68DE6" modified="2011-04-05" version="1">MAKKRVFSIVKAVKANARARVGIVPAERVIPDPKDKAARKPKHKETLAKLLEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM9</accession>
    <name>E8WYM9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">AciX9_0555</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0555"/>
    <dbReference type="EnsemblBacteria" id="ADW67627">
        <property type="protein sequence ID" value="ADW67627"/>
        <property type="gene ID" value="AciX9_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0555"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_0_0"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="396" mass="44130" checksum="5EEC3F25648E9ECC" modified="2011-04-05" version="1">MSLDLNGGRKRVLSGMRPTGKLHLGNYMGALHNWVKLQEEYECYFFIADWHALTTDYEDLSKLQSNIQDVALDFLAGGLDPEKSTIFVQSDVKLHAELHVLLSMFTSLSWLERVPSYKDQQEQLREKDLATYGFLGYPLLQTADILLYQPHFVPVGLDQASHVELTREIARRFNQLYPGSFFMAEGAAPWELEAVKTKARKNSGDAKKETFTPHELIAAAPQTKLKSGYGTRTILPEPEVLLTPSPKLPGTDGRKMSKSYGNTILMSDDEASVRAKLKTMVTDPARVRRDDPGNPEVCPVFDLHKVFSSAETQAEAAEGCVTAGIGCIECKGWLADGVVRALAPMQERRSYYESRPGLVDEILDAGGAKAWTRADETMRQVSEVMGLRYRSHGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN1</accession>
    <name>E8WYN1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0557</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578957.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0557"/>
    <dbReference type="EnsemblBacteria" id="ADW67629">
        <property type="protein sequence ID" value="ADW67629"/>
        <property type="gene ID" value="AciX9_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0557"/>
    <dbReference type="HOGENOM" id="CLU_144125_1_0_0"/>
    <dbReference type="OMA" id="QGFESAN"/>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14704" checksum="EBBB5E6C3FC45CE6" modified="2011-04-05" version="1">MVTQLEHDEAVERGNEALRTQPRAISARYDAASHRIVVELNTGYSVSFPPERAQGFESANSESLSEVEISFPGFGIHFPKLNADLWVPALARGIFGSKRWETAWLAAHPLEELPFRVSEAPSEGRQNEAQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP2</accession>
    <name>E8WYP2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0569</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578968.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0569"/>
    <dbReference type="EnsemblBacteria" id="ADW67640">
        <property type="protein sequence ID" value="ADW67640"/>
        <property type="gene ID" value="AciX9_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0569"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082091_0_0_0"/>
    <dbReference type="OMA" id="WLPYEAR"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="24669" checksum="72ECCCA11FC9AC4E" modified="2011-04-05" version="1">MKLITIHQKLFIIFRRRRMKQFFALFAPSAQTRVVDIGGATNTWLAETTNETAFPVTLVNLRFPDRLDGNRFTAVSGDATALPFADASFDIAFSNSVIEHMTTWERQQAFAQEARRVAGRLWIQTPARSFPLEPHLLSPFFQYLPRKLQTRLARHFTLWGLLTKPTPERVEEMISDIRLLTYREVKQLFPDCRILKERVLGLTKSYIAIRDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS0</accession>
    <name>E8WYS0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1708</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1708"/>
    <dbReference type="EnsemblBacteria" id="ADW68756">
        <property type="protein sequence ID" value="ADW68756"/>
        <property type="gene ID" value="AciX9_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1708"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_0"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230077" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="35908" checksum="D070A6C88494D29F" modified="2011-04-05" version="1">MKLKIVATGLLAMSAAMACAQNINGAGATFPYPIYSKWFTEYNQLHPEVKINYQSIGSGGGIRQVTEGTVDFGASDAVMTDQQIAEAKVKVMAIPTVLGAVVPVYSLPGVNQEIKFSQDAIAGIYLGKITKWNDPYIAKENPGVNLPDKQILPVYRSDGSGTTYIFTDYLAKISPEWLQKVGRAASVKWPVGIGQKGNEGVAGMVRQLPYSFGYVELIYAETNHMQFGLVRNAAGKFVKASTSGVTAAAAANAKNIPADYRVSITNAPGADSYPISSFTWLLIPVQSKDAAKGKALQGFLNWMLEKGEGEAAAMTYAPLPKAVADRVHQTIMSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY4</accession>
    <name>E8WYY4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2876</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2876"/>
    <dbReference type="EnsemblBacteria" id="ADW69899">
        <property type="protein sequence ID" value="ADW69899"/>
        <property type="gene ID" value="AciX9_2876"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2876"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_0"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="555" mass="60445" checksum="613C368B99DFF8D4" modified="2011-04-05" version="1">MPIQTTNPTNGMVLRSFEPLTQAAISGKLALAQLALREDRGVPLDYRALWMRKLAGILEHETEELATLLTTEMGKTIVSARQEILKCAACCRYYAENAERMLAPETIETGGNESYVRWEPMGVVLAVMPWNFPFWQVFRFLAPALMAGNVGLLKHASNVPQCALAIESLVRRAGFPRGTFQALLIESGQVEAVLGDARVAAVTVTGSEAAGRAIAAQAGWLVKKSVLELGGSDPFIVMPSANMEAAINAGVKARTMNNGQSCIAAKRFVIHEAVYEEFEMLFSAAMETLRVGDPMKEDTEVGPLATEQGLLDIEAQVAAAVKAGGRITTGGERMLGAGNFFEPTVIADLPRAAAVYRDEIFGPVAMLFRAKSLDEAIEIANDTPFGLGASVWTKDADERGRFVAELQCGGVFVNTPVVSDARLPFGGTKRSGYGRELSVAGMREFMNAKTVVIAEAVEPVRRVYEPIAVEKIAEEKISEEKLEQPEIEEPEIEDSVSFRAVPVMVQEKVEEKALFRSFTPEPTEHDFKQMLEKALENKTQQGVLVLMLCALLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ06</accession>
    <name>E8WZ06_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2898</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581236.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2898"/>
    <dbReference type="EnsemblBacteria" id="ADW69921">
        <property type="protein sequence ID" value="ADW69921"/>
        <property type="gene ID" value="AciX9_2898"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2898"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603773_0_0_0"/>
    <dbReference type="OMA" id="LDDFYIF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="317"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="453" mass="49554" checksum="A50B0F313F044B1C" modified="2011-04-05" version="1">MISSPVFTSRPPGKWRTLCASGALYLVSAIRTMSAQAPPQPKTSTLAAGLLQINLASNALISVSFLALSVIMLVLWKRSGKNLPHPWVVGTFGLFVLACALSQAMQLLIVLHPLSWMIGTIEILTTALALCIILLLPRMVRDFIELFRSAGHSQQNEARFLATAESSMDAVFLLDAVRDPAGEIEDFRFTYLNQRAQQLFNIPNNDVVVGAKLCELLPSYRSEGFFDQYKQVVLTGKPSTSEFSIKDAQINATWLRYSIVKLADGIAVAASDLTSQKEAENKIRHMAQHDPLTGLPNRTLLDDRIQQAIERAIRYRQNAAVLLLDLDTFKSINDTYGHAAGDEVLKTVAARLRSAVRATDSVFRLGGDEFVIVLGDLATKGPIVDFTRKIFVSLLPPIPWEDQALNISASIGVANYPGDGATPEALLVQADIAMYRMKRGRASTADLRSSQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ91</accession>
    <name>E8WZ91_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0622</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579021.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0622"/>
    <dbReference type="EnsemblBacteria" id="ADW67693">
        <property type="protein sequence ID" value="ADW67693"/>
        <property type="gene ID" value="AciX9_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0622"/>
    <dbReference type="eggNOG" id="COG4952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059875_0_0_0"/>
    <dbReference type="OMA" id="MIDQSHN"/>
    <dbReference type="OrthoDB" id="283831at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="401" mass="44573" checksum="EFE57639A4C7E35F" modified="2011-04-05" version="1">MPDLNGAVTEQDQQRVWAALDKFRIEIPSWGFANTGTRFGKFSQPAAASTIEEKFADAAQVNALTGVSSTMALHVLWDLPSGKSDIPKIQQLERTYGIRSGSINPNLFQDQEYKYGSICNPSAEIRGNALSHLLDSVEIGRALNSRDVSMWVSDGSNYPGTQSIRRRIEYMEEVLAATHAALGPDQRMLVEYKPFEPAFYHTDIADWGMALELARRAGPKAKVLVDTGHHLQGTNIEQIVAWLLHLNALGGFHFNDRKFADDDLTLGSIDPYQVFRIFHEILSDTTTNFNDIAFMIDQSHNLKGKVEAMVQTVATAQELYAKAALVDHAKLAELQKSCSLVEAEETFREAFWTDVRPIVRAWRQSHNLPANPLTALAESGYVEKISQERSAKNAASVSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ95</accession>
    <name>E8WZ95_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579025.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0626"/>
    <dbReference type="EnsemblBacteria" id="ADW67697">
        <property type="protein sequence ID" value="ADW67697"/>
        <property type="gene ID" value="AciX9_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0626"/>
    <dbReference type="eggNOG" id="ENOG502ZSRS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2569056_0_0_0"/>
    <dbReference type="OrthoDB" id="2101920at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="9275" checksum="30E65D7D21CFFB0D" modified="2011-04-05" version="1">MALKLTYWTLTLMFFVALTFSFEGHAYAYVDPGSSLLLFQSVSTVATGVLFYFRRRIKRLFTRTPVKPAQQPAIPVLARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB6</accession>
    <name>E8WZB6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0647</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579046.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0647"/>
    <dbReference type="EnsemblBacteria" id="ADW67718">
        <property type="protein sequence ID" value="ADW67718"/>
        <property type="gene ID" value="AciX9_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0647"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079636_6_2_0"/>
    <dbReference type="OMA" id="AQMMIRD"/>
    <dbReference type="OrthoDB" id="1992825at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234004" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="2">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="17575" checksum="2839A9D6DE7094C9" modified="2011-04-05" version="1">MNRTHLLTLAATLLTTSTLLAAPASDNDKAWQAKVSQGGMYEVEASKLATQKATAQDVKDLAVMEVHDHELVGAELKRLSLAAGLPFPSTLNPEFQQRLAKLKSNPAGPAFDAAYLEDMKQIHDKDEKLFAQESNDGSPAFKPFAAQTDRIVKRHIGALHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC5</accession>
    <name>E8WZC5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1765</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580132.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1765"/>
    <dbReference type="EnsemblBacteria" id="ADW68813">
        <property type="protein sequence ID" value="ADW68813"/>
        <property type="gene ID" value="AciX9_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1765"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422601_0_0_0"/>
    <dbReference type="OMA" id="DLYHRFY"/>
    <dbReference type="OrthoDB" id="250274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230486" evidence="2">
        <location>
            <begin position="19"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="648" mass="71144" checksum="BB40EA0C81A1BA6E" modified="2011-04-05" version="1">MAKTLPTLALLLSTAAYAQQPLTTAPPSGPAPRPYLTKREPTLTEAQKLALLRQHIKYVFVLFQENRSFDFYFGSYPGAEGLYSKPAAEIPGFTQPLVDTDGTVRTITPFRIPPFITDANGKAVPIYPSDLASVNHSHTAMDAKLNFDSADLSKNDRFALTEEGVTLNSEGKPSKFPSLERKQYGELVMGHLDCDTAPFLWRYADRFTLFDHFFATELGPSTPNAIAMISGQVGETQWMLHPEEVTRPGYPGVPMLADPQPFYGIKKESSGKAKQANDPKTKTNSVNFTFAALPLSFMGQDAKATTATDDDPAADLRDVKEDIEKIAGHPNRATPWGWYQQGYDHEPIDPAGQVTHKSYVSHHNAPAYFGYVANNAGVETHIHGLNDFFEDVAARRLPPNGVFYVRGGYGNIRGLHPLDPNPRLATVFNGNDDHPGYSDSQLSEALLAEEINAITQSPYWAQSAILIAYDESDGLYDHAQPHVRGHGPNKEPLDQGPRIPFLLISPYGNAHAVSHEPAEHSSIIKFVDNLFNLIPLADLPDEQKARAIGVEKFHEKNMGPADDQVEGIGNLFSAFSNARLLGKRPLLPASYAQIPVPEINAFPHYDYKGCSVMNIKPTDANLPNPIPADFNPRPDTTPGNPKSGNWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF7</accession>
    <name>E8WZF7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate phosphodiesterase metal dependent hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1797</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1797"/>
    <dbReference type="EnsemblBacteria" id="ADW68845">
        <property type="protein sequence ID" value="ADW68845"/>
        <property type="gene ID" value="AciX9_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1797"/>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044951_1_1_0"/>
    <dbReference type="OMA" id="RQPIFNR"/>
    <dbReference type="OrthoDB" id="753726at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HDOD" evidence="2">
        <location>
            <begin position="215"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="423" mass="46961" checksum="DEBDF017737A77CF" modified="2011-04-05" version="1">MRDPLQTPEQSIRKSGESSVTRFVGRQPILDAHQNIFGYELLFRAGLDNVFSGDAEDATRQMVDNALLIGLDTLAPGSKAFINCTREALVSRTVTLLPAELTVLEVLETVDVDDEVVHAVAELKQAGYQIALDDFLPGNSSDRLLCFANYIKLDFRALSHEELLSIQRELSASKIPLIAEKVETVEEFRRALAEGYQFFQGYFFSHPIISSSRHIPTNNLIYIQLLSALTKSPYDIHEVEKILMSEASICYRLLRLANSAQIAHRGEVTSIAQALMIVGEDQFRRLATIAIAVSLSKGVTVSYELVYLALQRARFCELLSSSAGQIQGEQYLIGLLSTVDAILQTPMQEVLSMLPLRPEATAALLGAASDTAVPLRLLHCYEQKQWTRCTELSKALKITDAQLTEMYVSASRWATSQLKAVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH7</accession>
    <name>E8WZH7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1818</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580184.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1818"/>
    <dbReference type="EnsemblBacteria" id="ADW68865">
        <property type="protein sequence ID" value="ADW68865"/>
        <property type="gene ID" value="AciX9_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1818"/>
    <dbReference type="eggNOG" id="ENOG502ZPJP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115824_0_0_0"/>
    <dbReference type="OMA" id="RDWQRFR"/>
    <dbReference type="OrthoDB" id="1845862at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230487" evidence="1">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="21015" checksum="F9651CB405A18700" modified="2011-04-05" version="1">MKRFWIAALLIAGTLPALSQTPPSPGSIEAHPTWPQSTTDALKTVDGTISALYAAISGPAGQKRDWNAFRSLFLPDARLVVTRVAGVANATKTDAVILSVDDYVNRVSTRFETSGFFERGIASRKEEYGVITHVWTTYESRHKTDDPTPFARGINSVELLKANGRYYIVQVMWDSERPNNEIPKEYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI2</accession>
    <name>E8WZI2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1823</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580189.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1823"/>
    <dbReference type="EnsemblBacteria" id="ADW68870">
        <property type="protein sequence ID" value="ADW68870"/>
        <property type="gene ID" value="AciX9_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1823"/>
    <dbReference type="eggNOG" id="ENOG5032WNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481305_0_0_0"/>
    <dbReference type="OMA" id="HKECTEL"/>
    <dbReference type="OrthoDB" id="1681698at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230106" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19894" checksum="BDE99C601042EACB" modified="2011-04-05" version="1">MLKLLPLLLLILTPPLHAQHPDNALSEGEVEKLRESAPEPAARVLLFSAFLDQRAKEILTLTTGRRHAGREEDIHDQLEQFSSIANDLEDNLEDYAPRHKDLRKSIPKLLAATDRWQTAVKTPPDHDAYNVSRRLALEAITDLREDLTKLLEDQKAYFQLHPPNKENKQDSKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK0</accession>
    <name>E8WZK0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ordered locus">AciX9_2951</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581289.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2951"/>
    <dbReference type="EnsemblBacteria" id="ADW69974">
        <property type="protein sequence ID" value="ADW69974"/>
        <property type="gene ID" value="AciX9_2951"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2951"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_0"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10646" checksum="D370343ED15CA140" modified="2011-04-05" version="1">MSRSTKKGPFIDAHLMNKITVMNQTNDKKVIRTWSRRSTIFPDFVGHTVAVHNGRKFIPVYVTENMVGHKLGEFSATRTFKGHSAKTESSAKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ0</accession>
    <name>E8WZQ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581338.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3001"/>
    <dbReference type="EnsemblBacteria" id="ADW70024">
        <property type="protein sequence ID" value="ADW70024"/>
        <property type="gene ID" value="AciX9_3001"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3001"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_4_0"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19136" checksum="CAB71A864B0D34D4" modified="2011-04-05" version="1">MPGKESFNKHIRKSLPELLGSVLDIVGIFNSPERDAAMLESAGLTLERALYPLLVLIGKYGPIGVVDLGERVGRDYTTVSRQVARLEELGLVTRRAGSTDRRTREATVTREGKAATNAVDAARERLALKMFRNWSRPDYDQLLRLTRMLADGLDVTPAPGSKLAERMAAKTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR4</accession>
    <name>E8WZR4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0654</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579053.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0654"/>
    <dbReference type="EnsemblBacteria" id="ADW67725">
        <property type="protein sequence ID" value="ADW67725"/>
        <property type="gene ID" value="AciX9_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0654"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_1_0_0"/>
    <dbReference type="OMA" id="MPVDEIH"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234205" evidence="1">
        <location>
            <begin position="20"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="602" mass="67134" checksum="EB58B0D179803B30" modified="2011-04-05" version="1">MRFYTLAASTLLFTTLSLAAQTTSVADRLAAQNKLFEESWQTNLKLSPTLATSVGDYRYNDQLGEYTLASVAKRHDINVAYLARIKAISPAGFSDQDLLSHDLFLRNLKENLDDYDLKDYEMPLSSSGGGGGIHTGVADLPLSMPFDTVKHYEDYIARLHQIPRAFLQTEEVLKIGVKDHLVPVRFIAEKVPSQCAGVVAANPFFIPIKKFPASFSEADKKRLTEEITNTVNNEIFPAYKQFSAFVTNDYIPYTRTALSVESLPGGKRRYQAALHRFTTTDLTAPQIHEIGLKEVDRIEAEMAVLAKANGYKDLATFRDHVESDPKYVPSSEQSIVDDFARYIARMQPKLIELFTVIPKAPVTVEAIPDFQKAAATHYQTGTPDGKRPGRVSVAVSDYGKRSFINDEAVAYHEGVPGHHMQLSIQQTLTGLPEFRKHGGNSAYTEGWGLYAEQLGKEIGFYEDPGSDYGRLRSELFRAVRLVVDTGIHDMGWSREQVVDYMRKSHAIDEPTIQAETDRYISGPGQACSYKLGQLKIRELRERAQQQLGPAFNIRTFHDEILSGGSLPLNLLDARVDRWIKSQLPANAAVPVGVSTLANRVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY0</accession>
    <name>E8WZY0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0721</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579117.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0721"/>
    <dbReference type="EnsemblBacteria" id="ADW67791">
        <property type="protein sequence ID" value="ADW67791"/>
        <property type="gene ID" value="AciX9_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0721"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_0"/>
    <dbReference type="OMA" id="RLTMLYP"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="23786" checksum="12F608FB6D32EF2D" modified="2011-04-05" version="1">MSLRINDIAPDFTAETTQGTIHFHDWIGESWAVLFSHPKDFTPVCTTELGAAASLEAQFAQRGAKIIGLSVDPVSNHDKWAQDILDVGGSAVTFPMIGDPELKVAKLYDMLAADAGETSEGRTPANNAPVRTVFVIGPDKRIKLTMAYPMTTGRNFDEIIRVLDSMQLTAKHKVATPANWKQGGDVIITGAVTNEEADKIFPGYKTVKPYLRTTKQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X001</accession>
    <name>E8X001_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1851</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580216.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1851"/>
    <dbReference type="EnsemblBacteria" id="ADW68897">
        <property type="protein sequence ID" value="ADW68897"/>
        <property type="gene ID" value="AciX9_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1851"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_0"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="50"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="356" mass="40404" checksum="3F7F077365B24B96" modified="2011-04-05" version="1">MDINEIRTKVAARQRITPEDAAYLWQNATNEELQALASQVRDRFHPAGSCTYMIMRIINYTNVCVAQCDYCAFYRLPSQDGGYVMQQAEVFAKLDELLQLGGDLAAFNGGFNPALPLAYYCDLFAAIRARYGDSLEFYALTIAEFMYLADHARLSYPETAQRFKAAGVRWITGGGSEILTEDFRRRHSKFKYTVAQYFEAQTAIVAAGLKTTATMVIGFDETLAERLEHLERTRQFQDQTNGLASFLCWTYKPYFTQIGGIEITTQEYLRHLALSRIYLDNVPRIRTSVLTQNERALEGLLYGADDFDLPIEDEVTQKAGATIDLHFDKILAYARTLGFTPTYRHVPQPEPVCSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X049</accession>
    <name>E8X049_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ordered locus">AciX9_1899</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580264.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1899"/>
    <dbReference type="EnsemblBacteria" id="ADW68945">
        <property type="protein sequence ID" value="ADW68945"/>
        <property type="gene ID" value="AciX9_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1899"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_0"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="39090" checksum="5206C5C7CE177F36" modified="2011-04-05" version="1">MAEQNTSPLSTIRTAVAGVGGYAGGELARLLLNHPRLAQSKPLFLGRVADDSSAGSVPLESLHPQLALGAGQTLPPVRAFDWKLVEDMGIEAVFLALPHETSREWAPQWLERGIKVIDLSGAWRLQHEVNRKVYKLTDENPALAASLQAEAVFGAPELHRKEIATARLVANPGCYSTSIILALYPLIQAGILDLDHGIISDSKSGISGAGKAATAKTHFMYGADNLSAYNVFGHRHTGELLEQLGITTAQIQFTPHLLPIPRGILSTIYARLGSSTDPAQIQQIYNAFYATSPMVRVHQTPALPQIQHIVKTNYCDIGFELAPDGKRLVIVSCLDNLLKGASGQAVQNLNIMCGWNEEEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X072</accession>
    <name>E8X072_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_3033</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581367.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3033"/>
    <dbReference type="EnsemblBacteria" id="ADW70053">
        <property type="protein sequence ID" value="ADW70053"/>
        <property type="gene ID" value="AciX9_3033"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3033"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_0"/>
    <dbReference type="OMA" id="RIVPPWI"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="224" mass="24629" checksum="9EDAF66710E75132" modified="2011-04-05" version="1">MNLPNSITMSRIASVPLLIWFLSPHSPFDAHNGNQEMAASSLFILASITDGLDGYLARKRQQITTIGMLLDPLADKLMITAAYIILVAYNPRIVPPWIAVLIIGREFLVSGLRSIAASEGFTIDASEIGKLKTVIQIVSVVAAILAHRWDYWNWGGFIVAVHFIAITAIYWMTCVSVISAVDYFIGFWKQIDHASERARTKRSNVLSRNKAKAVAAAENPSGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B1</accession>
    <name>E8X0B1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3072</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3072"/>
    <dbReference type="EnsemblBacteria" id="ADW70092">
        <property type="protein sequence ID" value="ADW70092"/>
        <property type="gene ID" value="AciX9_3072"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3072"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_1_1_0"/>
    <dbReference type="OMA" id="RTQYTIG"/>
    <dbReference type="OrthoDB" id="565919at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="48100" checksum="F3DFD7711AFD3C3E" modified="2011-04-05" version="1">MKEIVIAGAMALTLLGQQTGTGVAVAQQTTPQQQTIPDAPRPQGLPLTNVAPGKAPNTSNSNATDPDQPAVGSTLPNSPSQPTADDQGPPPVQPAPGQGPATFTLQLQTNFVEVPFTVKDNKGHLVPALSARDVRVYENGLRQHTAVFTSDPFPMSVAMVIDQSMPFDTMTRVNNSLEALPAAFASYDEVAVFTYNNGPRMQTDFTSGTSARLSAVLERSKSSGREAMYYAPGEGLGHGIDINNGAQKEITPLGTGGGVGTPQGVTQVPREVHTLNDAILEAAKSLSKAKQGRRRIIYVISDGKEYGSVAKTKDVIKFLQTNNIQVFATLTGDASVEGLGFIERIHVPLMMRDNNLKAYTDATGGALFAEYRQKAIETSFSQVTEQVRTQYTIGYYSREPFIDGKYRKLEVQILKPNLNVIAKDGYFPSASQASRQRPTAPVSTTPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C4</accession>
    <name>E8X0C4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">AciX9_3085</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581419.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3085"/>
    <dbReference type="EnsemblBacteria" id="ADW70105">
        <property type="protein sequence ID" value="ADW70105"/>
        <property type="gene ID" value="AciX9_3085"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3085"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_0"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14104" checksum="FE62F1C163C277E3" modified="2011-04-05" version="1">MAYPAAYKYTKSHEWLEVSGTTGSVGITDYAQSSLGDIVFVELPKVGDTLTAGKIFGSVESVKAVSDLYAPASGTVTEINEALNPAPETINTDANTTWLYKFDLTNPSELTSLDTLIEAAAYETFVAEETGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G9</accession>
    <name>E8X0G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase with extracellular sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579159.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0764"/>
    <dbReference type="EnsemblBacteria" id="ADW67833">
        <property type="protein sequence ID" value="ADW67833"/>
        <property type="gene ID" value="AciX9_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0764"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388719_0_0_0"/>
    <dbReference type="OMA" id="FIRIALA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="444"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="762" mass="82277" checksum="94C5CEF95408D3A5" modified="2011-04-05" version="1">MNPLSQRLRNAESSVFAAVARRPPSGFIEHATIRLVFVSFIAFASATFVPGTIGKLFWILAFTAMSVLTLFLMILIWRWIMGHILWKVRNRLIVTCLLLALAPILLFGTLISIASYVFAGQFGTSAAMTGIDEDLALASHRSDAIAHLPLSILTNETNFGRAGEHNVAHVWEDGTLHTLTPHAASTQPPASAPASPFATPAPPAWLHPGFSGLVAADGKLYLCAAGGAQTDSHSILVLESTPFGEEQVTTFATGLGSLNISPGIGVHTSLGANYTEDDKKKIDDEDDHAQFAVGKETGKGEMKDDDGNVVVIAKADGNAVKPVFTIGKPGTPKTPHLHKHKTDSDLDDEFNSFTSLHGGTLPPAHNSFDWPVFASSPLQVYSWKTGEKVGAWMMIQSRPSLLYKRLFSNSLEVGSFIRIALAVTAATFGILELLALLLAIGLIRTITASVADLYFATRQIETGNLLHRIRVKRRDQLAALATSFNTMSGSLAELMVQQREKDRMQNELNIAHEVQNNLFPHTPIGLPGLELYGICNPARTIGGDYYDFIPMGTAQVYLALGDISGKGISAALLMSSLYSAVRVYLQGGNKKSITAITPNAAPALAEPLPSPGKLLSLLNQHLYSSTQPEKYATLFLASYDSATRRLTYSNGGHLPPLVLCSDGKVTRLEAGGSVVGLLGGMEYKEATVQLNPGDLLIAYSDGLTEPEQDGIEFGEDRLIEVIRKNRHRPLPAIANYTVQCLKDWMGDGEQPDDITIVFARLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T9</accession>
    <name>E8X0T9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3107</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3107"/>
    <dbReference type="EnsemblBacteria" id="ADW70123">
        <property type="protein sequence ID" value="ADW70123"/>
        <property type="gene ID" value="AciX9_3107"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3107"/>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356723_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c_4" evidence="1">
        <location>
            <begin position="350"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="786" mass="89308" checksum="A76EF84E36986591" modified="2011-04-05" version="1">MQTIKGRPHYLTSIQIPADLVKFSTIPQNPQLVYLHGSIDHYTDQNLVEEVQKLDPQLVDRLLPLLQDHPLIVVGYRGAEASVMQHLLLQHATATNNFCHGVFWCTVKSETRQSLPTLVDDFAKTIGSNFTQVEIDGFDELFSRDLWKLHENAESFRETARSAVGSGQTQSFETEMLTPQQTEKLEWSTVTARISRYCETLRIRFPVHPERVWLTEQLHNLNLAAFDNEHRTCITKAGYLLFGKHPQDIVHPGKIKLTVRGTAKWLARVGNDVRDEIASGGETEESVERLIEGNLWSQYDQVNDILSAFNRPFRLKGEFSENVMPYPPLSLKEIVVNALVHRDYGRDELVEIDVEPTRIRITNPGGLVEEVRRSVENESIEEEIKRGARGIKGYRNPVLADLFYGGGVMDKRGSGLADVYKAIRENGGEIRFGANDDNSSFIVEIFCRPEAVDEITGTASPLVLTSSRYASNILEVTETPAELFHATSTCKNISQIWAELPDQNLPPFLFLGDKIYSFYELDSRHNPLRHVIDKGTMEEISFEEFVSLEDGDRRLIWLLNLTLERHFYELGLITDKKRKRAYFPRSEDGSVTMNYQARLKRATRTVVKPRVSSRTGVVTYWEHQSVSYRFEWLGDIIGLLIEPGYVFTSDGKKKLLAPERVNRLSTKRASRDYNNAVHNDLTFWSRTISGGENAYFDLNPGNFGERRIESQGRISTRKNGGLEEFMRSASITLSSRLPTVTTTDAALPADIEDFGEVSEQDMQELDSELIELAESQEEGASDVYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U0</accession>
    <name>E8X0U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3108</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581438.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3108"/>
    <dbReference type="EnsemblBacteria" id="ADW70124">
        <property type="protein sequence ID" value="ADW70124"/>
        <property type="gene ID" value="AciX9_3108"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3108"/>
    <dbReference type="eggNOG" id="COG1431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031104_1_0_0"/>
    <dbReference type="OMA" id="CCAAQMF"/>
    <dbReference type="OrthoDB" id="404766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="499" mass="55036" checksum="F0F022B597581BA2" modified="2011-04-05" version="1">MSIKIELTELPPPLLEFGSPGDFTDPRSGLREAGPFDLRFGAARSEKILVGLVGPREMVDRTALWLERCKGALDADNSRTQYPSFPGFSAIFRADLITASHLTVAFEGSNSDLDVALALVDPKLRFETVLDVFSTGIKRLAESEATRPDVIFCCIPDDLIAKCWSIENSLTEEDRTAAKALRKRKVDNQLALFEAEAIEEQPEDLLRRDFRRALKARAMRSRVPVQLATNGLVLDGASGQGPATRAWNSCVGLYYKAGGIPWRLRANGPETCFVGVSFHHLQTTKRHLVHSSIAQAFSNQGEGFALRGGSVDWSDEQGREVHLSSEQAAQLAVNILDEYRDRTGGIPLRVVLHKTSMFSAAESQGFRDALSSVPVVELINWMPTQFRLVRFGSYPPNRGTFCRVNNSKSYIFTTGYMPELGTYPGPHIPAPAELRSDLPQDLSVSARDILALSRMNWNTAGITGGTPVTLAFARKVGGIMSEFGQKGDEEPLTSFRYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C8</accession>
    <name>E8X1C8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobT</name>
        <name evidence="11" type="ordered locus">AciX9_2037</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580399.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2037"/>
    <dbReference type="EnsemblBacteria" id="ADW69082">
        <property type="protein sequence ID" value="ADW69082"/>
        <property type="gene ID" value="AciX9_2037"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2037"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_0"/>
    <dbReference type="OMA" id="AWMRKCA"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="35965" checksum="072EA87199F0D4F2" modified="2011-04-05" version="1">MTPDLQDTIANIPAPAPEALFRAHLDTLTKPLGALGRLEDLAAQLQTLGLTDLRKAAWVFAADHGIAAEGVSAYPAEVTRQMVLNFLSGGAAINVLSRLHNAPVHIVNAGVATALDSAPTLRNTPIRPGSRNMLHEPALSEAELNEALALGIECAAEASAKGFNLIAVGEMGIANTTAASALTAALTGRALYPVTGRGTGLDDAAHAHKIAVLEAVLAHHEPHLTTPEEILRRLGGLEVAAMTGFILGCASHRIALIIDGFISTAAAACAVALAPQVHSWLFAGHQSQEPGHRILLAHLNLTPILTLDMRLGEGTGAVLAMPILESALALYTQMATFTSAGVSAATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J9</accession>
    <name>E8X1J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase, A subunit</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581546.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3223"/>
    <dbReference type="EnsemblBacteria" id="ADW70234">
        <property type="protein sequence ID" value="ADW70234"/>
        <property type="gene ID" value="AciX9_3223"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3223"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_0"/>
    <dbReference type="OMA" id="FVKAWKG"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25120" checksum="557328891D7EF269" modified="2011-04-05" version="1">MHKVVETPEAALDGLTDGMTLMLGGFGLCGIPENLIAALVRTGLKGFHTISNNMGVDGFGMGLMLEAGMIASHIGSYVGENRRLEQQVLAGQLALTLVPQGTLAERIRAAGAGIPAFFVPAGLGTVVEEGKETRTIAGRNYILEQALHADVALVKAWRGDTHGNLIYRKTARNFNPIMATAARLTIAEVEELVPAGTLDPDHIHTPGIYVQRIVQGPAYTKPIESAYLKARKEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U2</accession>
    <name>E8X1U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2058</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580420.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2058"/>
    <dbReference type="EnsemblBacteria" id="ADW69103">
        <property type="protein sequence ID" value="ADW69103"/>
        <property type="gene ID" value="AciX9_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2058"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102506_0_0_0"/>
    <dbReference type="OMA" id="RFTELLY"/>
    <dbReference type="OrthoDB" id="1368755at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="20883" checksum="B2358566547D1847" modified="2011-04-05" version="1">MAQTKPISQAAPKRAPRIIAGSAAPAHDAARAQTLVNYEAALQLMQQGKYDKAHAAFDKMLLNSPADLAERIRMYINACLLQVSKGKTTFSSHEEEYDYAISLLNDGHYEDARTHFKAILSHNAKADYVFYGMAVLASMTGDCNTCLEHLTEAIRQNPRNRIQARADSDFQDMADDPRFTELLYPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y8</accession>
    <name>E8X1Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580465.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2105"/>
    <dbReference type="EnsemblBacteria" id="ADW69149">
        <property type="protein sequence ID" value="ADW69149"/>
        <property type="gene ID" value="AciX9_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2105"/>
    <dbReference type="eggNOG" id="ENOG5032X9H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168029_0_0_0"/>
    <dbReference type="OMA" id="MGHENDV"/>
    <dbReference type="OrthoDB" id="1893690at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="11779" checksum="395221F0C7B12944" modified="2011-04-05" version="1">MATLVTTDAPDQVRTAVRFPMRLSLMIHTGTGEMEATTENISANGILFTGPHLPAVDDRIEFTITMPANVMGTPEDLSIQCTGRVVRHQSHDGETQAAAIIDEYLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X207</accession>
    <name>E8X207_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2124</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2124"/>
    <dbReference type="EnsemblBacteria" id="ADW69168">
        <property type="protein sequence ID" value="ADW69168"/>
        <property type="gene ID" value="AciX9_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2124"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_4_0"/>
    <dbReference type="OMA" id="SPNVHYV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="459" mass="50172" checksum="3781B2688D402071" modified="2011-04-05" version="1">MAINMLDMIGVGPFITLPILLSAMGGPQAMLGWIFGALLAVCDGLVWAELGAAMPEAGGSYRFLRTMFPGELGRFLAFLFVFQLIFSAPLSVASGCIGLSQYAAFLAPSLGGHWWAWGRVSAGPGTLVAIACVALALVLLYRRLANLKWISYVLWTAVIATIGWILVTASLYGHLGRAFSFAPGAFHLTPSFFSGLASAMLIATYDFWGYYNVTFLGAEVKDPARTIPRAILISIGAVAGLYLLLNVAILTVMPWQPLVGETELGARQALVAFFMQTAYGGHLGMVLGRVAAGLVMITAFASVFSLLLGYSRIPFAAARDGNFFRIFGQLHARHGFPYVSLLYLGGAAMVFCFFSLKEVIAALVVLRIVVQFLLQHVGVMVLRKRRPDLPRPFRMWLYPLPPVLALAGFGYILLARPMFYRELGEALAVVALGALFYFIRRFRRSESRPENRPKWSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B2</accession>
    <name>E8X2B2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ordered locus">AciX9_0977</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579368.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0977"/>
    <dbReference type="EnsemblBacteria" id="ADW68044">
        <property type="protein sequence ID" value="ADW68044"/>
        <property type="gene ID" value="AciX9_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0977"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_0"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="379" mass="41613" checksum="FB9ED96BFC06E94C" modified="2011-04-05" version="1">MSDLSQIPETIAVAMSGGVDSSAVAALLHEQGYDLIGLTLQLWNQRRLAGHEGMPESVQGRCCSIDDVYDARRVAEKIGIPYYLVNQQERFEADVVKPFVSEYLAGRTPIPCTLCNNHLKFDQLLLTARQVGATKIATGHYARNRFDEATGRWILSRPADRSKDQTYFLFGLTQDQLAHTLFPLGEMQKPAVRVMATEAGLDVAAKPDSQEICFIPGGDYQTFLRAYLDEQGEELPDSSGELVTSSGEVVGRHTGIHNFTVGQRKGLGLTSANPLYVLAIHPDSHQVQVGSDAELMTRELRANRLNWISIPEITEPIRVLAKVRHRHEPQPATLSSGGIGPDGDPIAIAIFDEPQRAITPGQAAIFYREDDVVGGGWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B9</accession>
    <name>E8X2B9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0984"/>
    <dbReference type="EnsemblBacteria" id="ADW68051">
        <property type="protein sequence ID" value="ADW68051"/>
        <property type="gene ID" value="AciX9_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0984"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057821_0_0_0"/>
    <dbReference type="OMA" id="PPYLEHR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="154"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="35230" checksum="A29E1BFFED65B88A" modified="2011-04-05" version="1">MRSPIVGLHHVTAFSSNPQRNLDFYTEILGLRFVKRTVNFDDPGTYHFYFGDDAGSPGTIMTTFPGPRSARGQAGVGETSHVAFSIPLASLDYWHTRLTGLGVLVERTGKRFSEEVLTLADPDGMKIELVGTADVIAPKAPRFADVPAEHSIRGFFGVSLLLHAAEKTAAVLNMMGFAKVAEEGNRQRFSAPGDALGNHIDLVIDPAAKYGHFGAGSVHHIAFRAKDDEAQKEWRALIEQTLDVTPVLDRDYFHSIYFREPGGVLFELATDNPGFATDESIDTLGERLCLPEWVEPQRAKIEARVAPIELKKSLQKAQVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E0</accession>
    <name>E8X2E0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579395.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68072">
        <property type="protein sequence ID" value="ADW68072"/>
        <property type="gene ID" value="AciX9_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1007"/>
    <dbReference type="eggNOG" id="ENOG50349JT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091002_0_0_0"/>
    <dbReference type="OrthoDB" id="2179725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29758" checksum="8061CE3F57F04521" modified="2011-04-05" version="1">MIQNPPEDNSDQGYSKKRSDSVYGTVDATDGQLTVHYDPLRDEIEIEGAEPGSTRTETSYLRSSGKPKVVSSVPTFGLSRFTSAKALLDFDRVIAVDTNTHIVKGFRWSICASYHVPEPLNHYHGQIPWLPLGGFLISTVAEGVNPERIGWHLTLQNYLPRFRHDDERLAIIVDSELGQHREINTRKVGYYGANLLPPRTALVYASADKDKNTLQGTMIRACDAVSTQIWEQLAPRLGSFRARSQGLDPNYHFALPIRSPRTSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G6</accession>
    <name>E8X2G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2146</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580506.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2146"/>
    <dbReference type="EnsemblBacteria" id="ADW69190">
        <property type="protein sequence ID" value="ADW69190"/>
        <property type="gene ID" value="AciX9_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2146"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_0"/>
    <dbReference type="OMA" id="RLMRYEY"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230184" evidence="1">
        <location>
            <begin position="25"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="219"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="498" mass="52859" checksum="1C1841F4C32B9C6B" modified="2011-04-05" version="1">MTKWAGLALLPVLLAGVGTGAVQAQAKHAAGVTAAEPWKKIPIPPLHDFKPVQPTRIELANGLVIFLQPDHELPFIKGGILIRGGSRDEPADKIGLVSLYGQTWRTSGTPTESGEALDDALALKAASVETSGGLATTSLRWSSFSKDFDLVFGDAMDVLLHPAFKADKLALAKRQLDTGIARRNDDASGIAGREVSVLAYGKDSPYARETEYATVAAVKLSDLKDWHDRTVAPNNMIVSVSGDFDPAAMEAKLRQAFEGMKQGKKQLVSKGEYKDPKPGVYFVNKTDVDQSNVYIVGLGTERNNPDYYALSVMNEIFSGGFGSRVFQSVRTRLGLAYSVGGAYGASYDHPGLFTVGAATKSASTVAAVKAMEDEIGKLKTVPPTAAEMKSAKDQVLNSFVFNYDSPEKTLSEQVSLAFYGYPADFLEKYKSGIEQVTAADVTRVANKYIDEKKLAIVVVGNGAEFGGPLTGLGAVTDVDIAIPPPVAAGGPGGLPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N6</accession>
    <name>E8X2N6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage antirepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3324</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581645.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3324"/>
    <dbReference type="EnsemblBacteria" id="ADW70333">
        <property type="protein sequence ID" value="ADW70333"/>
        <property type="gene ID" value="AciX9_3324"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3324"/>
    <dbReference type="eggNOG" id="COG3561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046670_11_3_0"/>
    <dbReference type="OMA" id="QNNEMGR"/>
    <dbReference type="OrthoDB" id="872571at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005039">
        <property type="entry name" value="Ant_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013557">
        <property type="entry name" value="AntA/B_antirep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03374">
        <property type="entry name" value="ANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08346">
        <property type="entry name" value="AntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AntA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ANT" evidence="1">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="27341" checksum="DF8B368B01033CF4" modified="2011-04-05" version="1">MDALIEVAERQIGGGVVQSINARDLHAFLGSRADFSTWVKQQIERARLQQNRDYLIHKKVEQLPSGAKSRNEYFLSLDSAKHVGMMSRSERGFQIRDYFLECERRYHADGAGVAAVLQDPAALRTLLLGYSERVVTLEQENSALRPKADFHDAVVEATNCQTVQQVAKVLGTGPNRLFDFLRKHSILMPGNLPHQQHVNAGRFRVVEGHYKDRHGDRQTYTRTLVTGKGLAFIQRRLSESTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q5</accession>
    <name>E8X2Q5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581664.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3344"/>
    <dbReference type="EnsemblBacteria" id="ADW70352">
        <property type="protein sequence ID" value="ADW70352"/>
        <property type="gene ID" value="AciX9_3344"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3344"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051652_0_0_0"/>
    <dbReference type="OMA" id="YITRCEF"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="341" mass="37510" checksum="7F0DF5C0AF823FF0" modified="2011-04-05" version="1">MPTKTLPIGIYYEQPNWFKPLFAELDKRGVDYVKIDAVTHMYSPADHPEEKYSLVFNRMSPSAWNRDHGDQIFYTAGYLEHLETRGVRVLNGLAAFRAELSKAGQLSLMEELGIAYPKARVIHRASQAPAATEGLRFPVVVKPNIGGSGAGVKRFDHISQLEAAAAQPADHPDALAFGLDSTALVQEFIPARDAHIVRVEVLNGKFLYAIKVHITGETFDLCPADICRTTTGVDLDRGACAIDAPKSGITVEAYTPPAEVIEDVERIMFASQIDIGGVEYLTDDRDGQRYYYDTNALSNFVADGKNVIGFDPFEKLVDWLEAEATSALQERQEIATGMAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y7</accession>
    <name>E8X2Y7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1058</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579444.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1058"/>
    <dbReference type="EnsemblBacteria" id="ADW68121">
        <property type="protein sequence ID" value="ADW68121"/>
        <property type="gene ID" value="AciX9_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1058"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_0_1_0"/>
    <dbReference type="OMA" id="PMLWVSN"/>
    <dbReference type="OrthoDB" id="1381894at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="64"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="27664" checksum="0B18DC5F8BD03170" modified="2011-04-05" version="1">MHVLRALLRTAKLIGYFTWFGLELLIRRPATRQARADWLHRFCAAALRGFDVKLTVEGEFPARGALISNHLSYLDIIVFAAMSPCVFCSKAEIKHWPILGWMTTMAGTVYVDRGRGGSAAKAGGEMKLAAEAGLPVVFFPEGTTSNGEQVLAFHSGLLAQAIGAEEPITGAYLSYSLDEENGEGVSVSDDVAYWGDVNMLKHIFRFLGLQGCHARVRIGDGPIAFRCGVKDRKGAAREAREAVLELAGTFVNTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X392</accession>
    <name>E8X392_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="9">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmhA</name>
        <name evidence="11" type="ordered locus">AciX9_2278</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580632.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2278"/>
    <dbReference type="EnsemblBacteria" id="ADW69316">
        <property type="protein sequence ID" value="ADW69316"/>
        <property type="gene ID" value="AciX9_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2278"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_4_0_0"/>
    <dbReference type="OMA" id="DVHICVP"/>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="36"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21875" checksum="7454F8BD347C7CEC" modified="2011-04-05" version="1">MKDLVRRQLALSIATMQAVHDSDEIHDTMVEIGRLTADAMRNGKKLLVAGNGGSAADAQHLVAEFVVRLTVNRPALRAIALTTDTSILTATGNDFGYDAVFSRQIEALGQEGDVFLGISTSGNSPNILLGMAEARRLGLTTIGFTGNGGGKMREACDYNVIIPSTTTMNIQESHLALEHIFCMIVERFTFGMDFDKAPQIVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B0</accession>
    <name>E8X3B0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3405"/>
    <dbReference type="EnsemblBacteria" id="ADW70411">
        <property type="protein sequence ID" value="ADW70411"/>
        <property type="gene ID" value="AciX9_3405"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3405"/>
    <dbReference type="eggNOG" id="COG4456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301870_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="11776" checksum="77A5B94D4C1A8981" modified="2011-04-05" version="1">MAANPIPHQSEFVEVEILEDESGQFLRLPEAFRLDATKVLLHRATNRRILVEPLSEKRRKWTHEEVQALADQFDAHNREFGPFMAEGRNQPPMQERDWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E4</accession>
    <name>E8X3E4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable Fe(2+)-trafficking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fe(2+)-trafficking protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581756.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3440"/>
    <dbReference type="EnsemblBacteria" id="ADW70445">
        <property type="protein sequence ID" value="ADW70445"/>
        <property type="gene ID" value="AciX9_3440"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3440"/>
    <dbReference type="eggNOG" id="COG2924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170994_0_0_0"/>
    <dbReference type="OMA" id="SKQTMLI"/>
    <dbReference type="OrthoDB" id="2038019at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00686">
        <property type="entry name" value="Fe_traffic_YggX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36965">
        <property type="entry name" value="PTHR36965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="SSF111148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10790" checksum="F35BD452E0A534C1" modified="2011-04-05" version="1">MPHMVFCSKYKAELEGLDEPPFDSDFGQKIYKNVSKKAWGEWVERQKMLLNEYRLQPWTAEAQSFLVEQMNGFFFNEGEGGELPKEFVPPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L0</accession>
    <name>E8X3L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1138"/>
    <dbReference type="EnsemblBacteria" id="ADW68201">
        <property type="protein sequence ID" value="ADW68201"/>
        <property type="gene ID" value="AciX9_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1138"/>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741084_0_0_0"/>
    <dbReference type="OMA" id="KHRYETA"/>
    <dbReference type="OrthoDB" id="1042869at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="42052" checksum="BBC0AE3C7F209FE2" modified="2011-04-05" version="1">MSFGLAGGLLLAGCSRFHEKPNEHYVFVTSKQGYLRDRVAAVSNRTAQVGNGDRLKVLDHARHFVKVQTDKGAIGWIEEKAVATPEVADEFDALKEEHKNDPAVASAVVRDTVYLHVKPGRDAEKFYLLAEGEKLKMLKRATLVKAVTQMTAAKAQKAIPQASGTNAARKGGVAEIVAAEAPAPPAMEDWWLVTDSQGHTGWIFSRMIDVDAPDSLTRYSEGQRFVGAYILTTVHDEGAPTDQKDIPEYVTVSSPYKAGLPYDFDQVRVFTWSMTHHRYETAFRDKNIEGYLPVTIGKMKDAYGKTPIAAMELPSYSYKVLSADAPAVVPDVATGAMVPGKTVTKAYRLEGNIVRRMGAPGSTAGEQLARPVAEDEKKGKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N5</accession>
    <name>E8X3N5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_1163</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579549.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1163"/>
    <dbReference type="EnsemblBacteria" id="ADW68226">
        <property type="protein sequence ID" value="ADW68226"/>
        <property type="gene ID" value="AciX9_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1163"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26875" checksum="BDC3D61AE7471CD2" modified="2011-04-05" version="1">MRVLSTEEIGKSYGGREVVRGVSLSISQGEVVGLLGPNGAGKTTSFYMIVGLVRPDAGRVLADGVDITRLPMYLRARQHRISYLPQEPSVFRKLTVEENILAVLEVQNLSWELRRTRTERLIEQLNLGHVRKTRGYALSGGERRRVEIARCLCIEPAFILLDEPFAGIDPIAVLDLQEIIFGLKASGIGVLITDHQVKETLSVTDRAYIINEGKIFATGTPGELGRNPEVRRVYLGDKFSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S9</accession>
    <name>E8X3S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2320</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580673.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2320"/>
    <dbReference type="EnsemblBacteria" id="ADW69357">
        <property type="protein sequence ID" value="ADW69357"/>
        <property type="gene ID" value="AciX9_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2320"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="THNTAEA"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="33059" checksum="BEAEEAFEB7AED4DB" modified="2011-04-05" version="1">MVSVLEPMPETVTTSAAKAEATAIHIADVSVSYATKKKTRKTILNGVNLEIADGEFVVLLGETGCGKSTLLRMILGQELPAAGAVFVRGKKVERVSAQCGYVPQKYSLFPDRTVMGNLIMGPETSKFHILGRLRPEFRAFRREVKAEALRQLQHMGLHATDADKYPHQLSGGMQQRVAIAQALMMKPNVLLMDEAFSALDPATRTSLQRILRTVWLETKPTVVFVTHNTAEALFLATRVIVLAKQGVNGQDGAKVALDLKLPETGMSLKRNGQQFLDLVEHIEDASRGSAVADESTPSPEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W0</accession>
    <name>E8X3W0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3463</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3463"/>
    <dbReference type="EnsemblBacteria" id="ADW70468">
        <property type="protein sequence ID" value="ADW70468"/>
        <property type="gene ID" value="AciX9_3463"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3463"/>
    <dbReference type="eggNOG" id="COG1964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_0"/>
    <dbReference type="OMA" id="FCAYNTG"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="160"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="711" mass="79064" checksum="D5AAD332ED52B975" modified="2011-04-05" version="1">MAKAKPAKLVENAMVGVAKVAWGVFSRLNNISPNDSFTPRWSDKPLLKSYQKEKPPLGWPRTTDSLCPGCVPAIRQQIVDGKLPHEILLNEKVGEIKAQIIERDGQILMVKDCPIHGHYEDVMSIDPAFFKHLEEVFPGRDIRAHNDEKLHNHGTSTVTHGRGSVLTIDLTNRCNMMCDPCFMDANQVGFVHELTWDEIKTMLDNAVTIKPRRQMSVQFSGGEPTLSPYFLDAVAYARKVGYTSVQAATNGIEFAKSKEFSKAAAEAGLRYAYLQFDGIGNAANSHRKVGNSFDVKLQAIHNLHEAGVDIVPVTCIINGINNEQVGRIIEFALDNPKKINFLSFQPVSFTGRDEAISDERRMAQRYTLSHLAHDVKNQTGLGEPTRDWFPISFMSTFSDWADLVHGPDRDWGQLSCGCHPNCGISMALMIDKETKEAVPVTAFINADRLAKDIARVNDAARGKTLTIIGATLALLRNYKPEAAPTHFKIKDLLEKFDKSFGATGRSYGKVTADRTMEDIAKRRGDRWNFLFIAGMWFQDLFNYDFRRTEQCIIPYATQEGEISFCAYNTGVGWRNIIEKMHMTSTLTKWYEEHGRHEIFAGGKKVGLEKESSYDLVLNDAHVNSAANDTFDKSGIAKNAREEKIRARDAKLKQDAENSKMAALYRKEVLGEKAPEGGFVPLGAIGGLGGITPAPKSNVEVVSSIEETVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X1</accession>
    <name>E8X3X1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_3474</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581790.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3474"/>
    <dbReference type="EnsemblBacteria" id="ADW70479">
        <property type="protein sequence ID" value="ADW70479"/>
        <property type="gene ID" value="AciX9_3474"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3474"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_5_0"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="292"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="778"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="929" mass="102780" checksum="688D27C209A5DD63" modified="2011-04-05" version="1">MSRLLEKMNPQQQQGIQTVDGPVLLLAGAGSGKTRVITHRIAYLIEERGVSPDAILAVTFTNKAAKEMAERVDKIIGHSSLAKPTLSTFHSFCVRVLRRDIEALQVGGKGLTRTFAIYDETDQQAVVKSALKRLGIDDKSLKPRVALGRISWAKNHMIDPQEYFLASTNPLEEKIAHIFEIYKKELNKANALDFDDLLLETVRLLKSSGETRARYNRRYQYVMIDEYQDTNKPQYELMKLLAGDHKNICVVGDEDQSIYSWRGADIKNILDFEKDFPAVQTIRLEQNYRSTQMILEGASAVVAQNTQRKGKNLWTAREGGSLIGLYEAPDGENEALFIADRIKKYLREAGQTETEEPARCAVLYRTNSQSRLVEEALRRYQIAYHMVGGFSFYDRAEVKDILSYMKLVQNPHDSVALGRSVNSPPRGIGKTTMETLERMALTTGMSTWDAIARAIEEKLLPARALQALSGFKRLIEDARAMLGPGFAEKLAEDVEAETADDEEDVSFGFSVEAEPVETGADAAADTSFDTSFNFGFDFGPSEEISTLAAENSVDSDAAHNIGSVSFNPFAPVVLKESAASASAAARRAVANEEKELAAQEPERPAFRKAGDAATLPELIKFLNERSGYIRALEDEATPESFSRIENLKELANAAQDAQERGETLHEFLDHAALVSDADSYSAEAKVTLMTLHAAKGLEFPLVFLAGMEEGLFPHSRTFTDPTGLEEERRLCYVGMTRAMDTLVMTRARYRRRYGSDMPEASVASRFLEEVPGRLVEDLGSPAAQPQFSSSYSTPYPQRGRFGQKPGYEEGDRHYSYEDEDQSGERKAAAAPGRQMAGQQSPAKSLDNVAAFFASRGGAPGAKFARPKLDIPAATGKTGLGKGSRVRHPKYGEGIVFQREGDGDDAKITVQFQQHGVKKLVEKFAQLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z5</accession>
    <name>E8X3Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin, RelB/DinJ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3498</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3498"/>
    <dbReference type="EnsemblBacteria" id="ADW70503">
        <property type="protein sequence ID" value="ADW70503"/>
        <property type="gene ID" value="AciX9_3498"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3498"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_12_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="8900" checksum="20D86EF5655D1FAB" modified="2011-04-05" version="1">MATTALVVTMDESLDREASAVLAGIGFTVDQAVKLLLTQVVKEKCLPPSLHVPNQDTIDAMQELKDGGGEQFANVEDMLASLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X414</accession>
    <name>E8X414_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3517</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581833.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3517"/>
    <dbReference type="EnsemblBacteria" id="ADW70522">
        <property type="protein sequence ID" value="ADW70522"/>
        <property type="gene ID" value="AciX9_3517"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3517"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1220" mass="130645" checksum="C92C54FA390AA59A" modified="2011-04-05" version="1">MRTLVATKSTPSSLASAIRLATVILLAVLCFFSTGSRLDAQIGGSGSISGTVTDPSGAVIPNALIVAVNNANGTRVTQHSSGAGAFTLSPLEAGQYTVTIVATGFEKLTQEHIQVNALQIVGLKPQLTLGVSTETVTVEGAPPQLDTQNASIGGTMENAEYVALPLQINGGARNPTSFVYLEPGVAHGGSGVQTGIFSGTGSAGRLDEVYIDGFPQTSIYEQGDPRYVSNLVSVEAVDQFQVITSNPPAAYQGVGLENYTIRSGSNKIHGSVFDYYRDTSFDTWGFFQPNVINPLLGHATKPNEHQSEYGVSLSGPIKKDKIFLFANYDGFYLHKDNNPTYSTIPTLAMRSGDFSQFLTLATPQAIYDPTSCPTGSQSAGTCTRTQFAYNNQPNVINPARIGAAETFMQKFQPTPINSNITNNYLSQIPSFQHHFSTMEHLDWTINDRQRFSVIFGAQLGAVYGFQSNGSNPGPLPYTSGQGFETKNKLIQAEHTFTINQHLVNQFKAGYTRFWGPVFNPDYRTPGFGLGTNAGVTGLPGGQASGSFPTVTWAGNNPLTQWSGDQDYNDITNYATILDNVQYIKGKHTFTFGGTHQWLEVQDIAYTTGISPVTLTYSNSQTALYTNKTGISSTGHSYASFLIGQVNQGSLTQQSFIDTGARIQPSSLYAQDDYKLTSKLTLNIGLRWDYYPAYREVINRSTFLNINATNPITGNKGALEYAGSGTGPYCNCNTPVNSWYKNFGPRLGFAYSVAPGTVIRGGYAIAYTHGSGTRSALFKGTGTVGLSSAPSIVSKTSGDAAFLLDSGFPAYTAPPTINAGYGTFYTTLSNTPASSMSYPDPYLGSRAPYANMYNLGIEQQLTKDMAVQINYVGSQGHFLPVSASGARGYFSNQLNPQYLKLGSLLGTTVTPAVIAQAQQVFPGIQLPYASFSGTLAQALVPFPQYSGVSDTYDNLVNSNYNSLQFIIKQRMSRDIDFMFNYTWSAEIDDNGTFRSGYLSNRVERGRGTADVPNVINSTAIVKLPFGKGQPLHSNNRFLNSLMSDFSLSAIYTYSSGIPLAIISSGCVAPGTGQCMPNYNPNYTGSKVRINGSYGQGVTAATAATTHYIDINGFIDPSAATSSTATAAQKAAYPNYTIGNVARTAPYGLRGPTAFDGDVSLKRTITLHDNVNLLLDVSAYNITNSVILAAPGVSTSTPSTFGVSSSQSNLSRDIQLAARINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X431</accession>
    <name>E8X431_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ordered locus">AciX9_3534</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581850.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3534"/>
    <dbReference type="EnsemblBacteria" id="ADW70539">
        <property type="protein sequence ID" value="ADW70539"/>
        <property type="gene ID" value="AciX9_3534"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3534"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_0"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21946" checksum="83D651029243369A" modified="2011-04-05" version="1">MASAMASIVALKDVHQQLKTRFEKTVDDFRANLLSARTGRASVHMLDQVKVDYYGTDTPISQVAQITTPEAQLILVQPWEQTLVTAIEKAIRTSNQGFNPMHDGRIIRVPIPPMNEERRKEAVKNLAGVLEGHKTSMRNIRRDGNELIKKAAKDKLISADDEKRANEEVQQLTDAEIKRLEDLFKAKEKELMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X466</accession>
    <name>E8X466_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0035</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0035"/>
    <dbReference type="EnsemblBacteria" id="ADW67126">
        <property type="protein sequence ID" value="ADW67126"/>
        <property type="gene ID" value="AciX9_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0035"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_0_1_0"/>
    <dbReference type="OMA" id="EMGIYTT"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230214" evidence="2">
        <location>
            <begin position="20"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="626" mass="70381" checksum="EAECD5CB56B03E0B" modified="2011-04-05" version="1">MRAPRVLVAVSMLSAVALATAQAPAMKPATAKPATTAKPAMTTAPAAKTEDSNPAPISPFPQGPPSKPGLELKTIHTEDRKWREAQRGYVDPRRMNRIQPKELRSVDAATQAKEYDHLKGVMAQLEKLPVAEMNESEKINLEIYRYQIESQMSGQYFKEWEKPVSSLESFWANAQGTGERGFRTEQDYLNYLTWLADIPRYYDENIANMRAGLARGFTPPKITLNGRDQTIAPIAKATSADQTPFWKAFVHMPSTINTAEQARLRAEGKKVIESTVIPEYKKLLPFWTDEYYPKTVTSIAATDLPDGKAYYKAQIKRYTTLDLSADDLHAFGIAEVAKIHQEMLDTMVEAKFTGDFAAFQKFLRTDPQFYPKTKEELLGDVSYMMKEFDDKSDRYFGYQPRGRFGVHPVPDEVAPYQPAGFGGAGGFSINLYDLPSRPLYGMPALVLHEAAPGHSWAGLIAREHADPDGFRGGGSAFGEGWALYCERLGTEMDMYHTPYEKFGMLSFQSWRASRLVVDTGMHAMGWTREQGQQYLRDNTVLSEHDIEEEIDRYISWPGQALSYYMGMTEILKERKHAQEVLGPKFNLRAFHDAILATGGLPLPVLDEYLEAWIKGGGIGPYPEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B7</accession>
    <name>E8X4B7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1181</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68244">
        <property type="protein sequence ID" value="ADW68244"/>
        <property type="gene ID" value="AciX9_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1181"/>
    <dbReference type="HOGENOM" id="CLU_573379_0_0_0"/>
    <dbReference type="OMA" id="HGHEFAR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="476" mass="50886" checksum="1420C1096CAC1B45" modified="2011-04-05" version="1">MGEHGQPLGGSRVGGNVPVAMHTPGIPAGVRPQALRGGGAQYTDQRGRTVVTNPHGQVTEFRDQNHIAQYDGRGQARFIQATHNGMTTTVTHGFGGQRTIQTRYADGTRVVSYGAHSGFAERAIVGRPGFVARTTSMGGITRVSVYRSYSYQNHAYYRYVPAVYYRPAFYGWVNSPWRRPVVYNWGPRPYGGYYGAYFTPYPSYPTPDLWLTDYVLNYNLQQAYAARQDVGDGPQQGFDGPPDQNYQDQSAGAAPQQQPFDDVGNAPVGQPGPAPEGVPVAAQQTQLDPTVKALIAQQVKIDIAEMQTASAQASVGAGEAPMPPDSAMPEVLKPDHTAFEVSSDTQLYYGDNQSCVLSPGDVLYRKPDSTADITGGVEVTVVGRKPGSCDVNVTAKVSLATLQDMNNQFQQQLQGGMQVLAAKAGKDSIPSAPDSGQIMVASGQAPAQDVNSMLAQNQTSGQQAETEIATAATGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C2</accession>
    <name>E8X4C2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1186</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579572.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1186"/>
    <dbReference type="EnsemblBacteria" id="ADW68249">
        <property type="protein sequence ID" value="ADW68249"/>
        <property type="gene ID" value="AciX9_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1186"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="ALFTIHH"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="23716" checksum="6F21C3EDA5F32540" modified="2011-04-05" version="1">MNRLILADDQVIFRAGAARVLSQEEDMRIVAQCEDAARLTSVIASFRASIVIFSSGLALDLPILLASIQEAGSRAILIADKDHHLPEAVYAQLGGIISRSVTGPQLIEAVRRVAKGQRSIERSAVSTMPSHDAVGARVRDRLTPKELQIVALIVQGCKNKDIATQLNTKEQVIKNYLRSIYDKTGVSDRLELALFTLHHRLLAEAAAKAGTLIQMKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D7</accession>
    <name>E8X4D7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1201"/>
    <dbReference type="EnsemblBacteria" id="ADW68264">
        <property type="protein sequence ID" value="ADW68264"/>
        <property type="gene ID" value="AciX9_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1201"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606460_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="505" mass="56218" checksum="C6A9A7D5F0237B64" modified="2011-04-05" version="1">MTYAHNDILNGWKEIAQYVARDIRTVERWEKQRGLPVRRVPGAGRATVFARISELELWLHSSNLAETEPLIALEDQTHSRPTALAIAELPTLSEAATSPTIDSPAPPVLYQPVRPDPAASLIHHKYFIPAMALILGSVFAIFITQPLARRAAAHTPPPAHGISAVSASPAGPVRQSQVPGVDALYLRGTFFFEQRTPDTLNRALQHFTAAIEKDPTYAPAYVGLANTYNLLREYSVVPDEIAFPKALEADEKAIALDPSLPQAHASLGFVKYFWSVDAPAAEREFQTALALDPSLVLAHHWYGSVLTHEGRYTEALRELDTAQRLQPSSSAIFTSRALAFGLSGHRDEARAMLEEHLSQDHNREDHNSSTTHIVLGILDMMEPHDVPGFLHEWRRGAERRQDSESLDLVNKAEAAYHHGGEPLMWQIMLAAEQKQHSYSTARTVRMADSEVLLGRPDQALADLDDLMHRHDRAIISIFVDPMLFPLQKDPRFVNLRAELRLPPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H4</accession>
    <name>E8X4H4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579624.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1238"/>
    <dbReference type="EnsemblBacteria" id="ADW68301">
        <property type="protein sequence ID" value="ADW68301"/>
        <property type="gene ID" value="AciX9_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1238"/>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135601_1_1_0"/>
    <dbReference type="OrthoDB" id="1647539at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="15437" checksum="053D0847AD9A16B8" modified="2011-04-05" version="1">MLTYVFEASSLLRFLDNEAGADRVKELLNLSRNGVCHAEISAVHWGEMVSTIARKRGLQHVAELSKLPAPYHLNIIPATADRAHRAGLIKFTQKIPYADAFAVELASDSPDHILITADFDMKPAENDIQIEFLPTKQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J7</accession>
    <name>E8X4J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2370</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580723.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69407">
        <property type="protein sequence ID" value="ADW69407"/>
        <property type="gene ID" value="AciX9_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2370"/>
    <dbReference type="eggNOG" id="COG1836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_2_2_0"/>
    <dbReference type="OMA" id="AYGKRTF"/>
    <dbReference type="OrthoDB" id="1903232at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="28528" checksum="CBDF59B1FD91A852" modified="2011-04-05" version="1">MEMENVWRKNISEARDRIQSRILVCVVSPLLVLLCLHGLTFGPAGGRAGIFNSLLALGISVAFALLAWKLGSATPGAAASGGAICLLLVQVGGGLVVRSGLLPLVALFILTFASTRAGRRKKTKSGLAESRKGRNAAQVMANLGAAGLVAGAGAGHPWVFVVLLAALVEATADTVSSEIGQAFGGEPVSLVSLRRVAVGTDGGVTLLGTMAGILGGALVALVGYGAMGIGLKGFAVALGCGAAGLFFDSILGATVERWGWLGNDLVNFTSTLFAAGLAFALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M0</accession>
    <name>E8X4M0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ordered locus">AciX9_2393</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580746.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2393"/>
    <dbReference type="EnsemblBacteria" id="ADW69430">
        <property type="protein sequence ID" value="ADW69430"/>
        <property type="gene ID" value="AciX9_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2393"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_0"/>
    <dbReference type="OMA" id="PHNFQLI"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="27087" checksum="DAF4DE1621FE2940" modified="2011-04-05" version="1">MEPLVIAGRTFTSRLIVGTGKYKDGAETRSAIEASGAEMVTVAVRRVNLDRSTESLLDFIDPSKYFMLPNTAGCYTAEEAIRAARLGREVGLSDWVKIEVIGDLPTLYPDIQATVEATRVLVKEGFTVLPYTSDDIVFAKRLIDVGAAAVMPLGAPIGTGIGIANISTLRMMRELITEVPLVVDAGLGTASDAALAMEMGFDAVLLNTAIAGAKDPVLMAKAMGKAVEAGREAFLAGRMPKKLYATASSPMDGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N8</accession>
    <name>E8X4N8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2411</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2411"/>
    <dbReference type="EnsemblBacteria" id="ADW69448">
        <property type="protein sequence ID" value="ADW69448"/>
        <property type="gene ID" value="AciX9_2411"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2411"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_1_0"/>
    <dbReference type="OMA" id="PLEICNI"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018335">
        <property type="entry name" value="Tscrpt_reg_HTH_Crp-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00042">
        <property type="entry name" value="HTH_CRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="25534" checksum="048AC4CF6AFBCEFB" modified="2011-04-05" version="1">MPDRPLLDCTNCEHRSLRMFCNLDEQALQHYAAIGSEANYQRGVMLFREGGRSDGVFVVCTGQVKLSCTSKEGKTLILKIAMPGDVLGLSAVISGSPYEVSAETVEPTQVKHIQRDAFLKFIDRFGEGSLHVAKALSADYKTAFFDARRLALSGSAAGRLAGVLLDWGKSAGSCGKFEMRFTMALTHEELANLVGTSRETITRTLTRFKKESLIQIKGSSILITAPELLEKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P7</accession>
    <name>E8X4P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580773.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2420"/>
    <dbReference type="EnsemblBacteria" id="ADW69457">
        <property type="protein sequence ID" value="ADW69457"/>
        <property type="gene ID" value="AciX9_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2420"/>
    <dbReference type="HOGENOM" id="CLU_1935081_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14005" checksum="A8499FAD67CBAE79" modified="2011-04-05" version="1">MLRSSLAVILGFIVMFFLKIVLILVTVKLTGPHPPVPTVGYLIYNVAAACILTAIGGFVTGFVAEARRVRHGLILAMVILVMSALSYTHYKGLQAPWYQVMLVVVPPMFAVAGAKLAELLAVRHSATART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z7</accession>
    <name>E8X4Z7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578517.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67189">
        <property type="protein sequence ID" value="ADW67189"/>
        <property type="gene ID" value="AciX9_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0104"/>
    <dbReference type="HOGENOM" id="CLU_1223308_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="25459" checksum="7C2ADE2119C940CA" modified="2011-04-05" version="1">MWDLLHPVYSVQAVTSSTKRGTLINVGNRDVIVHQITYNLTVLSPDDPKYANTADRDPTHWHIGHVHGTFLLNESLGVGHLLKYENKADAFKWADIESLEYYFGGAPDDHPVNFWEKIRRKRKVAALFGMGAVVDEVTFFDLVNHCYVLSAHAISDPEYQSRGEHHNATFDSMDTSATIEFYPVSPNSNPQVSEIPSIIDVISHDNDRPDTCKKTEYGSAQSEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X524</accession>
    <name>E8X524_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="2">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578544.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0140"/>
    <dbReference type="EnsemblBacteria" id="ADW67216">
        <property type="protein sequence ID" value="ADW67216"/>
        <property type="gene ID" value="AciX9_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0140"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_1_0"/>
    <dbReference type="OMA" id="MKHARIR"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="34347" checksum="ED03F6AD121FD567" modified="2011-04-05" version="1">MTHSTDIHQDVASLNARLANIQTKSGYALGLETEEGVLDLTATGAALGMSAPRDMDDLLQHGLGEQVRRIRDAVADRPETAVLIKLQDVIFAPLVTRPEKIICVGFNYEKHAEETGTPIPKAPPLFAKFSNALNHHNGVVTLPTRVDSHFDYETELVIVFGRRCRDVKEEEALDYVAGYSIGNDVSARTLQQQTTQITAGKISDGFAPVGPWLVTRDRIADPNNLRLQTFFNGERRQDWTTSDMIFDCRKLISYITGIMTIQPGDILFTGTPQGVILGEKIPAMLRRWVKPGDEVISTIEGLGELRVTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B7</accession>
    <name>E8X5B7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Colicin V production protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2428</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580780.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2428"/>
    <dbReference type="TCDB" id="9.B.160.1.7">
        <property type="family name" value="the colicin v production (cvpa) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69464">
        <property type="protein sequence ID" value="ADW69464"/>
        <property type="gene ID" value="AciX9_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2428"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092720_4_1_0"/>
    <dbReference type="OMA" id="QLGWADK"/>
    <dbReference type="OrthoDB" id="2032521at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="21132" checksum="D9065E009FBB2669" modified="2011-04-05" version="1">MQLPPTTSYNPFDWFLVVILVISTIAAFMRGLIRSLLSLVGFILAIVVASWNYLSFASYLGRWILNFTVAEIIAYLTILIVITIAFSMLANLLRKTASAVGLGFLDRLLGAAFGVLRGFLAGVAAMMAIAAFSPNSEWVKNSQLTPYFLEGAHAVSFVVPPRFEQQIAQGATHLLQQTPDLLKSHPRKNDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J6</accession>
    <name>E8X5J6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3620</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581934.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3620"/>
    <dbReference type="EnsemblBacteria" id="ADW70623">
        <property type="protein sequence ID" value="ADW70623"/>
        <property type="gene ID" value="AciX9_3620"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3620"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_0"/>
    <dbReference type="OMA" id="MMTHGVK"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="15184" checksum="6184106DE14C5C1E" modified="2011-04-05" version="1">MSISKRDEGKKVNSNINVTPMVDVMLVLLIIFMVITPMLNNKVNVDLPTAAAAVVMENANKEDAVTVAVTRDGKSFLGADQVTNEDIGSKISAKLENKTDKEVFLRADNRANYGKVMDTIDGIRTAGVSQLGLLTEKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N6</accession>
    <name>E8X5N6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEGA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3662</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3662"/>
    <dbReference type="EnsemblBacteria" id="ADW70663">
        <property type="protein sequence ID" value="ADW70663"/>
        <property type="gene ID" value="AciX9_3662"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3662"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198420_0_0_0"/>
    <dbReference type="OMA" id="MINRISA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="2">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="231" mass="23458" checksum="0EAED7DFCDE30A29" modified="2011-04-05" version="1">MDGTAVKLRLAETITSANAKVGQSVSFEVVDEVDVMGVMVVPKGAQALATVTEAQSKRSMGRGGKLDVNIDSMRLADGEKAALRATEGGKGGGHTGAMTAGIVGTAIVFFPAAPLLLFIHGKDISIPKGTEVTAFVAGDMHLEMAKFVPQDAPGVVAGTAVAQMASLAVDASVAGADIEVDGAFVGNTPSTVSVAAGKHEITVKKSGYQDWTRNMTVSGGAVRVSAEMVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X611</accession>
    <name>E8X611_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4115</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572807.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70895">
        <property type="protein sequence ID" value="ADW70895"/>
        <property type="gene ID" value="AciX9_4115"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4115"/>
    <dbReference type="HOGENOM" id="CLU_011142_2_2_0"/>
    <dbReference type="OMA" id="IASQTTY"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="187"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="27001" checksum="755049018A7FBD02" modified="2011-04-05" version="1">MSLSILNNISALQAENQLSITTAAANKSLQQLSSGSRINSGSDDAAGLAISDGLNANVAALNQSSLNATNAVGSLQTADGALAQVTALLNRSVTLATEASNTGLSSAQSTAINNEFQALLTQIGNIGTSTNFNGTAVFGSTVSAFTSDGTTNGTVSIGGAVAALTTTSLGLNASTLATSSGAQAALTVITAAISTVSAQRGTLGATVEQLQAASTVDTNESQNLVSASSNITSADISTVVANDTKYSILQQTGISALQQANQQAQTVLKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X676</accession>
    <name>E8X676_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4181</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572872.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70960">
        <property type="protein sequence ID" value="ADW70960"/>
        <property type="gene ID" value="AciX9_4181"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4181"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="REYPKMT"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1171" mass="123395" checksum="0EA9120DD4D05891" modified="2011-04-05" version="1">MSPSRPFILRPVATALLMVAIFLAGAVSYFQLPVSALPEVDYPTIQVLTFYPGASPDVVASGVTAPLERQFGEVAGLSQMTSTSAGGVSVIVMQFQLSLDIDVAEQEVQAAINAAQSYLPANLPTPPIYSKSNPADAPVLTLALTSNEMPLSQVEDLADTRLAPKISQISGVGLVSISGGQKPAVRIQANPTALAAYGVNLEDLRNSLTGNSLNSAKGNFDGPTQDYTINANDQLLSSGDYKSVVVAYRNGAPVMLGEVAKVVDGVENSTLAAWMNQTPAVILNIQRQPGANTIQVVDSITKLLPQLETTLPKAVHVQIVTDRTTAIRASVKDVEFELMLTIGLVVMVIFLFLRNVAATIIPSVAVPISLIGTLGVMYLAGYSLNNLTMMALTISTGFVVDDAIVMIENISRYIEEGEEPMAAALKGAEQIGFTILSLTISLIAVLIPLLFMGDIAGRLFRQFAVTLAVTIVISAFVSLTLTPMMSARLLKYTPPEEQGWFYDKSEEVFESIIRFYGRTLRFVLRFQTITLLVAVATLILTVVLYMTVPKGFFPTQDTGIIQGITQASPTISFEEMSKKQEDVAKVLLADPAVESISSFIGADGTNTTLNSGRIQINLKPLEDRGISAPDVIDRLGPKLEKVEGIKLYMQPVQDLTVDDRVSRTEYQYTLEDPNQAELNTVTHDFVARLKKLPELADVVTDQQLGGAAASLVIDRATASRFGITPTTIDNTLYDAFGQRQINTMYTQLNQYHVILETAPEFQKNPNKLNDIYIQGSTSGTVAAVASSSGGTSSGAGAGATAQTGNALLTASSTTGVGSSASSSSALSSSSSSSGSSSLTTVNGSSALSSAANSQTSTTALGSVSSAANTSSSTNTATNGTTRSGSGTSTASGSSGGSSSSSSGTISNPVPLSAFTHFTNSSEALSINHQGQFPAVTISFNLAAGYSLGQALDAINKTIKEANLPASVVKDYQGTASAFEGSLSNEGLLILAALVTVYIVLGVLYESFVHPITILSTLPSAGVGALLALRFFHLDLDIVAIIGIILLIGIVKKNGIMMVDFALEAERNEGKNATEAIYQASLLRFRPIMMTTMAALLSGLPLAFGSGIGSELRKPLGVAMVGGLLFSQVLTLYTTPVIYIFFDNLGARFSKRPSNKTAAQGKNVHEAQAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A9</accession>
    <name>E8X6A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4215</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572905.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70993">
        <property type="protein sequence ID" value="ADW70993"/>
        <property type="gene ID" value="AciX9_4215"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4215"/>
    <dbReference type="HOGENOM" id="CLU_013590_0_0_0"/>
    <dbReference type="OMA" id="GARSFYY"/>
    <dbReference type="OrthoDB" id="912440at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="750" mass="83535" checksum="4C0DAE060377AB19" modified="2011-04-05" version="1">MPHGVRAGSENDAAADARKAYSAKEAKAYTYKFDSTKPFLPSNMQTDTGEFIDPKSFPTAQYCQHCHQAAHAQWRQSAHANSNRVPYYLRNVNLLIAEKGISFSRHCEGCHDPVAMAAGAITDGAPRKRPYDQDGVTCMVCHSIKSVDTRGTGSYVLAEPAVLVDETGQPIHRPVSDGEILSHLDRHSAAVMKPLYKTPEFCSTCHKAALPHQLNDYKWQRAISLYDEWQNSSFAKESPLPFYKKDVVSTCQTCHMQREDLGSASDSGAKKNQLVSHRWLGANTVIPQIYHYPEQGEKVTAFLQNAVFNVDLFALEPEATASGQPALIAPLGMSAYTLTPGQRVTASVVIQNKGNAHSHVPEQRDMYESWVAFTVKDAAGKTIAESGFIQPGGELDESAHSFTNRLINKQGGINSLHQVWDNRVVAYNNTIQSGRSQLIRYAFTMPKSGPVTVTAAVRYRRFDQHFIDFGMSMPAGQHYQQPIVDMVSTTRTFAVGVNSAIKPLPNENPEWMRWNNYGIGLLDAQQYAGSVAAFEHVAKLRPDYPDAPTNIGLTYIQWEKYDEAMPYIEKSLALGKDNARALYYRALVERNQGQVDEAIVDLQKVAAQFPRSRDAHRELGFSYYQQHKYPLARAEYETVQSIDPDDLAAHYNLAILYRRLGLKDKATEQAAYFADQKDDPTASVYALEYLRKHHEIAQESVPWHVHDLDHKGKDEPLPATAASASATMAVLHRLEAPELLPDPTAQGGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q1</accession>
    <name>E8X6Q1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3925</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71201">
        <property type="protein sequence ID" value="ADW71201"/>
        <property type="gene ID" value="AciX9_3925"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3925"/>
    <dbReference type="HOGENOM" id="CLU_583637_0_0_0"/>
    <dbReference type="OMA" id="HWQFFVQ"/>
    <dbReference type="OrthoDB" id="200714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230810" description="Alginate_exp domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="2">
        <location>
            <begin position="75"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="52919" checksum="8593B3BFC4F07AF4" modified="2011-04-05" version="1">MKVNIRCRRTIRTNLFAALAVSTLLPGIVFAQTPAPSSAPATTPAQAGPLYADYPQKRGKVQPLQFETLPSWATLNMELRGRTEGQTSINYTENGDRTYELTRVYGGLEVRPTKYVTGYLQFIDTHALGLPLHVVAANMRDVFDLRQGYVNVHLKPGKVPVELIAGRQELKFDSERIIGISDWTNNSRSWDGFDARIGDKNRIDLFSTSVVAVHASSLDKHGAGLTFHGAYATLGTWVPHVRLSPYVLFHDVRGVTSQQNIKGNEVETTFGAEVQGNLPANFSYEANGSLQRGSYSNDSIHAGQNFDKLWYTAKTLPWQPRLGGEFDYATGNDHKDLTRIGTYDQQYPSNHNAFGLVDLFGYQNIRQERINLDLGPTKNLSLLVQGGFLNLATTKDSLYSSSGSVTIKAPTAGFNSTDIGKEFDASAKYVFHDYIVANVGVGHLFPGQMLIGNNHGAADTIGYFSLTYRYRVDKHSPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R4</accession>
    <name>E8X6R4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Xylose isomerase</fullName>
            <ecNumber evidence="2 9 10">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xylA</name>
        <name evidence="13" type="ordered locus">AciX9_3938</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
            <plasmid evidence="14">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the xylose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 9 10"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71214">
        <property type="protein sequence ID" value="ADW71214"/>
        <property type="gene ID" value="AciX9_3938"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3938"/>
    <dbReference type="HOGENOM" id="CLU_037261_1_0_0"/>
    <dbReference type="OMA" id="TLAMYEI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="12">
        <location>
            <begin position="147"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW71214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="48286" checksum="9C2AC45CEF3261DB" modified="2011-04-05" version="1">MTKTIFEDLPTVRFEGEASENELAYRWYDADRVVSGKPLSEHLRFAVAYWHSLAMNGSDPFGAATIHRPWMAGGDPMAAAKAKADAAFDLFRVLDLPFYTFHDRDIAPEGDSLKESLANFHEMAEYLGRKMEGSKAKLLWCTANLFSHPRFMAGAATNPDPEIFAYSATTVKHCMDVTKALGGANYVLWGGREGYETLLNTDLKQEIQQLGRFLTLVVEYKHKIGFEGQILVEPKPKEPTAHQYDFDTATVYGFLKQFGLENEVRVNLEANHALLAGHTFEHEIATAASLGILGSLDINRGDPLLGWDTDQFPNDLQSMTMSMYHVIKAGGLGKGGCNFDAKVRRQSFEGEDVVAAHVGGVDLCARGFLLAAGLIEAGKYDQVVAKRYAGWQTPEAQAMLNGSMPLEAIAAKAEAEGIDPKPRSGRQEQIENLLMRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T1</accession>
    <name>E8X6T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3955</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71231">
        <property type="protein sequence ID" value="ADW71231"/>
        <property type="gene ID" value="AciX9_3955"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3955"/>
    <dbReference type="HOGENOM" id="CLU_399961_0_0_0"/>
    <dbReference type="OMA" id="YTNFRSA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="688" mass="76557" checksum="8FF41DF3588D3075" modified="2011-04-05" version="1">MQNDSRLRLRQILMEAVFRRQRLWWTVFVGILVLTVLVIVFLPKRYEATAKLVVANLRTRSTLSAGPVNRIVTTEDVSQTQINSEVDLLKSQAVVRAALGLPNIPVGDPRQLKAEQETVKRIQDHLSIDPVRDSSIIDVRLIDKTPEMSVFHLTSILESYLNQRKVLTQSANAADFFDRQAQLFSGDLANARDALTKFEEGHELVDMDEQKKLQIERVAAIEDQIAAAKSNVANQTSRTRNLLQRLASTPARTETVRRSLTNQYSQERLNTNLVELVNRRDELLHRYPPTDRAVLALDQNIATARSALDEAALHPASDSSTDVNPIWQQVTTSLVTSSAEVSGSSAAQKELERQHGVAEGRLHDLQQSTQAYDVLKRRYQEAQTGYNLYVQKRDEARVGEALDKDQLFDVTLVQRPITSIIPVRPKPLAYAVAGLLMALILASVLALYADSSDLLVYTPQQLDAVTGVRTSGTLAEEINGSEAPENAIEFRRLLTSLRSSLVQGTDGARGKRIAVTSARPGDGGSYVSEHLAHEASAQVKLRVALLDMTRLLEATRSNHAVTVGLQRDETTLCWELAFPGSAVADSSLLILGQFGKQTFWTDLEPALQNADKHFDMIFLDCPSLRDSTLAIYLDGIVDGYVAVVAAAAARKRQIRQMVSFLQQTETPVLGYLLNRRTYPIPHWLYRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X725</accession>
    <name>E8X725_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3848</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582156.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71134">
        <property type="protein sequence ID" value="ADW71134"/>
        <property type="gene ID" value="AciX9_3848"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3848"/>
    <dbReference type="HOGENOM" id="CLU_543771_0_0_0"/>
    <dbReference type="OrthoDB" id="1123871at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="501" mass="54886" checksum="387BF5A6C9E7FFBB" modified="2011-04-05" version="1">MTQVLLTGKGERISFGLFELDPHSGELWKSGMRVRLPGQPFKVLVALIRQAGEVVTREELQAEVWDSNTTVDFERALAGTINKIRDALGDSADNPRYVETLTKRGYRFIAQVTYTHTPMADAAPARAAADDPAEARAALRPSPPYAVALPVPVELLLPTSEVETALLPAVSMDKRRAARWSVRERVLGAAAAILLLALLTTLYYWHRPLHPQPLRIEQISHFIPIFSGPPNAESFLTLATDGDRILTSVSVDGRPRLSAIYISTGEVHKLATPKELSSNSLEDISKDGSKLLLRSQLSSESEQPLWVTPSAGGSGLRIGNVLAQDATWMPDGVSILYANGNDLYTVQADGGSSKLYATLQGRAFWMRWSPDGRLLRFTLVDPVTHSTNLYELEAGSRTARPVRLPGLTPQPACCGTWTADGGAYVFEASENLWELEGEYHSPTLIQLTNGPLRFFSPVAARSGFRIFFLGLEPTSGLQQFSEARHEFQPAPAFLADANRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X742</accession>
    <name>E8X742_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4320</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572995.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71276">
        <property type="protein sequence ID" value="ADW71276"/>
        <property type="gene ID" value="AciX9_4320"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4320"/>
    <dbReference type="HOGENOM" id="CLU_007999_0_0_0"/>
    <dbReference type="OMA" id="PYNKLID"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="7">
        <location>
            <begin position="893"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1222" mass="139347" checksum="85830453252C7EC9" modified="2011-04-05" version="1">MTQFWEFFTFELKFRVKSISTYVYFLLWFTFEFLCIASESFGPIGNANGKVLLNGPYANTYNYIGASFFGVIVIAAIFGTSILRDFQRDTIQILFTKPISKVAYLGGRWAGSFVTTVFAFSGMLFGGVLGTFAPWADHTRIAPNHLFWYLQPFFSVSIVQIFFLGSLFFLVAALSRKIFIVYLQGAALFILYFIGSNAVLANQTLERFWPAIFDPIGFVYSDSIARYWTVVEKNSQLFAWSGVFLYNRLLWSAIGLLSLLAVWKLFPISVEALTAKASSKRANLRREQEEAVRPRRSLVAVPLPRVQQFFGSGTSFAQFLSLTRIRISNIVHEIPFWGILILMIALACVNGHYAGHFAGENVWPVTYLMLQSVEGGASLFFYIVATLYGAELMWRERDTRFDGIHDALPMRETTDWLSKLTALCFVELVLLTVAGICGITMQTVAGYYHYELLQYAKELYLVAFPQVLIFVLLALFVQTVVSNKFIGHGIVILVFVITPILSNFGWENTLYLPGNTTSVTYSDMNGYGHFVQALIWSSGYWLGFMCVLGVISVTLARRGSETGWAARFKLAGQRAPRLLPAGILFLLVTVGSGFWFCYNAHVLNVYINAKQGRKIQAQYERENKKYIHQLQLKLIAVDTKVDIFPERRSFAGSGHFVLQNKYPTPISQVHISDAHSGAFGAINTEPSIQEISFNRPFHVVSVSSNRQYTIYEFNTPVAPGETVEMTFKVSHTSRGFKDGHESPEFAYSGTFFDQAWFPNIGYDTGVELQDPRRRREEHLGELELLPHRGDPWGSLISQDYIKYRTTVSTSDSDNEGQPQIAISPGYLQKDWHENGRHYFTYDMGDVPMAAWFSFNSGRYQVTRDVYQGINGPIKLEIYHVPSHTYDLDDMMQSSKASLAYYEKNYGPYQFKQYRIIEYPRYRQFAESLANTVPFSESIGFIDRVEKPDDIDFAYFVTAHEFAHQWWGHQLIGGNVEGSNMMSESLAEYSALRVMEKKYDTDRMHKFLTHELDGYLRGRAGELRHENPLVLVQNEIYVWYQKGAMVLYALSDYIGEDKLNAALHDFLMQHQYPNVNTTQEVPYPDTRQLVNALRAVTPPEYQYYITDAFENIVLYDNKALTATYVQTSDKKYKVTLTVQARKVKADGNGTESPMPLADYIDVGVFSGKKDHEKQLYLKREKLTQEKQTFEIVVNELPARAGIDPYNKLIDRVSDDNEIDVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X743</accession>
    <name>E8X743_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4323</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572996.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71277">
        <property type="protein sequence ID" value="ADW71277"/>
        <property type="gene ID" value="AciX9_4323"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4323"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_0"/>
    <dbReference type="OMA" id="CAYSAII"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="8"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="385" mass="41277" checksum="BE148D42F8402E6D" modified="2011-04-05" version="1">MKALVYHGPKKVSVDTVPDPKIEKLTDVIIKLTTTNICGSDLHMYEGRTDVEKGKILGHENLGEVVEVGKAVDTVKKGDKVVLPFNIGCGFCANCEHGLTGYCLTCADPKVMPGMAGAAYGFAGMGPYQGGQAQYLRVPYADFNCLQLPPDVDEKENDYVMLSDIFPTGWHSTRLANLEAGQSIVIYGAGPVGLMAAMSARIQGAAQIFVVDGQEDRLALAKQIGATPINTKDGEIGDQIREATGGWGADCGAECIGYQCHNSKGKEVPNLVMNALVDAVKATGQIGVVGVFVPQDPGSDDKLAQKGQIAFDMGKFWFKGQKVGTGQCNVKAYNRRLRDLIHQGKANPSIIISHSLPLSEAPDAYKHFDNRDHGWTKVILKPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X764</accession>
    <name>E8X764_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4346</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71298">
        <property type="protein sequence ID" value="ADW71298"/>
        <property type="gene ID" value="AciX9_4346"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4346"/>
    <dbReference type="HOGENOM" id="CLU_2825089_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7379" checksum="C6FBAFD31971C915" modified="2011-04-05" version="1">MPALRDFIKRLGPLEESICSKCCQIIRPRHGGSTLQAAQSEHHCGEFSLNTVKRGEFSQIQDQAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X786</accession>
    <name>E8X786_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4368</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71320">
        <property type="protein sequence ID" value="ADW71320"/>
        <property type="gene ID" value="AciX9_4368"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4368"/>
    <dbReference type="HOGENOM" id="CLU_160611_1_0_0"/>
    <dbReference type="OMA" id="LWRCSNP"/>
    <dbReference type="OrthoDB" id="1872036at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="12120" checksum="A7AED0BF9510F3A4" modified="2011-04-05" version="1">MKAAYPTTPDGRYFVVKGRLWRCTNPSLPAATKAVLVKELMQARRFKGEAMRKGDTAGRQQARQRVDLVKHQLGERGPVWWNDGAPDLNRHIVINTPYADWFIGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D8</accession>
    <name>E8X7D8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4424</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573091.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71372">
        <property type="protein sequence ID" value="ADW71372"/>
        <property type="gene ID" value="AciX9_4424"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4424"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_0"/>
    <dbReference type="OMA" id="PVAHHVC"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="455" mass="49555" checksum="FDC7AE3FB3F947C3" modified="2011-04-05" version="1">MAYQSVNPYTEKLEKEFASHTDKELDGIIAQAHAAFQNDWRSKTMEERKALMKKAAAILRAQRVDFAKLITLEMGKLFSEALGEVDLSADILDYYADNAASFLAPEKLAVDEGEAYIESDPIGVLFCVEPWNFPYYQLARVAGPNLMAGNTLVVKHAANVPQCALAFEKLFYDAGAPKGVYTNVFLSNEQSATAIADKRIKGVALTGSERAGSAVAAEAGKALKKNTMELGGSDAFLVLDDADMDTAIKWGVWGRMNNTGQCCVAAKRFILDEKIADVFLTRFQEELSKLIPGDPMDEKTTLGPLCTAGALDLVQKQIDTALSGGAKVLMGGKRLDRPGYFLEPTVLTDITPQNPVYYQEFFAPVALIFRVKNEHEAIRLANDSPYGLGGSVITTDIVRGKHIASQIETGMVFINQATWTAPNLPFGGIKNSGYGRELSDLGIGEFINKKLVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J3</accession>
    <name>E8X7J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4481</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71427">
        <property type="protein sequence ID" value="ADW71427"/>
        <property type="gene ID" value="AciX9_4481"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4481"/>
    <dbReference type="HOGENOM" id="CLU_069356_25_6_0"/>
    <dbReference type="OMA" id="GPIFYRL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23697" checksum="50B410558A8764C2" modified="2011-04-05" version="1">MIRKVSKPRRAAKEVAAKPGPAMVEHRGNRHGRSEGARTAILEAADNLLVERGFAGVTIEGIAAAAGVAKQTIYRWWTSKTDVLMDAFLEDMIQASVPSDSGDLKSDLKHHLVGLAKMLAESDTGAVFRALLAEAQHDSELATRLRTQFIEPQRLRDLFPFEQARKRGELYPEFDTDAALEQLLSPIYYRVLVSGQPVSQSYVESLIRRLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV68</accession>
    <name>E8WV68_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0169</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578571.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0169"/>
    <dbReference type="EnsemblBacteria" id="ADW67243">
        <property type="protein sequence ID" value="ADW67243"/>
        <property type="gene ID" value="AciX9_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0169"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023677_1_0_0"/>
    <dbReference type="OMA" id="YNISWAY"/>
    <dbReference type="OrthoDB" id="250274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230335" evidence="2">
        <location>
            <begin position="23"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="552" mass="56796" checksum="21E1AEFBC5F71006" modified="2011-04-05" version="1">MVRKLAALSASAALVLTGCGGAGVTLTAPAAPAAVPVTSAQVIKHVVVIFGENVSYDHYFGTYPTATNPVGETAFTAAAGTPTPAGYTSALLTANPNNTNNKNGAGASNPFRLDPAQAATGDQDHNYGPEQTAFDNGAMDLFPLSVGVPDGANLTAATGKVAITNTNGLTMGYYDGNTVTGLWNYAQHYAINDHAFGSTFGPSTPGAINVVSGQTNGAVNDVNAGTAIVADGNGGFTDVGDADPTGDLCSSTSQSIHMTGNNIGTMLSTANITWGFFEGGFDLSKTNANGTTGCGRTTTSQVTGMLKADYIPHHEPFQYYAATSNPNHLRPTSIANIGKQDQANHQYDTHDFTDALAAGSMPAVSYLKAPGFQDAHAGYSDPIDEQTFIINTINAIQASPFWSSTAIILTYDDSDGWYDHMPMIVNGSATAQDSYSGTGLCNTTTASSTTALPGVSAATLHAQGRCGYGPRIPLLVVSSWSRKNALDSTVVDQSSVPKFIEDTFLGGARIGGGSFDSIAGSLNNMFNFTSSTVPNPNVVLLNPVTGAVTSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC6</accession>
    <name>E8WVC6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578629.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0227"/>
    <dbReference type="EnsemblBacteria" id="ADW67301">
        <property type="protein sequence ID" value="ADW67301"/>
        <property type="gene ID" value="AciX9_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0227"/>
    <dbReference type="HOGENOM" id="CLU_1523074_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="19024" checksum="EA817D42547EF9EC" modified="2011-04-05" version="1">MDLSELLPVVAALIVAMLGMIAFRSSSRIASKAVRLAMRILAGSLAAIPLLIATALIFFALNYTRHLPQQISPDGRLIAITTYTVNNGTGVDQAEISIRHPWNPYAHRVYAGPAEYKPNAKTPDPEAQWLDSTHLRVRFNTYASTANSPGLTPQGCATQAEGVTVVCEETRVHAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD8</accession>
    <name>E8WVD8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1324</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579709.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1324"/>
    <dbReference type="EnsemblBacteria" id="ADW68386">
        <property type="protein sequence ID" value="ADW68386"/>
        <property type="gene ID" value="AciX9_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1324"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_0"/>
    <dbReference type="OMA" id="MEVYRYE"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="196" mass="21453" checksum="800C4AA9D12734A8" modified="2011-04-05" version="1">MKKPLPTSPAEPPARKPRADAQRNRALILDVAREVFTRSGGNASMDEIARSARIGPGTLYRHFPTRDDLLSAVYITEVEKLAEAQKKLSAELPPIEALRAWLLVFIDYIATKKIIASALDAMAGGPSRVFQQGGQIMEDAAKALATRAVATHDLRPDVDLMDMLRAIYGIAFAGNTDDWPAKARMFVDILLQGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM5</accession>
    <name>E8WVM5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3 4">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2524</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2524"/>
    <dbReference type="EnsemblBacteria" id="ADW69554">
        <property type="protein sequence ID" value="ADW69554"/>
        <property type="gene ID" value="AciX9_2524"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2524"/>
    <dbReference type="eggNOG" id="COG3588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031243_0_0_0"/>
    <dbReference type="OMA" id="DYREMLF"/>
    <dbReference type="OrthoDB" id="945470at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="PTHR11627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="364" mass="39718" checksum="247B3973EACE111F" modified="2011-04-05" version="1">MECHKVNMQTLEATAKMMVADGKGLLAIDESTETCNKRFAKWGIPQTAESHRLYRELIVNTPGLSESISGAILYDETIRQEMNDRIPFAEALAARGIIPGIKVDLGAKEMAAFPGEKVTEGLDGLRARLAEYAQMGARFAKWRAVFAIGDRTPSHGCVEANAHALARYAALCQEAGLVPVVEPEVLMEGSHTLDMCSEVTERVLRSVFRELYAQRVKLEGMILKPNMVLPGVTCPVQESVEEVADATVGCLLRSVPAAVPGVVFLSGGQSGELASARLNAMNVRHKSRLPWELSFSFGRAIQEPALEIWHGNQANVIPAQKALYHRAKCDRAAHRGEYSATVEADHEMSVQDEVDYLAYAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS6</accession>
    <name>E8WVS6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Iron-sulfur cluster assembly scaffold protein IscU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3684</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581994.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3684"/>
    <dbReference type="EnsemblBacteria" id="ADW70685">
        <property type="protein sequence ID" value="ADW70685"/>
        <property type="gene ID" value="AciX9_3684"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3684"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_0"/>
    <dbReference type="OMA" id="YKNPRNY"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="14908" checksum="A7CCBBA0F3FBE95B" modified="2011-04-05" version="1">MAYSDKVVDHYSNPRNVGQMDKSLDEVGTGLVGAPECGDVMRLQIRVNPETQVIEDAKFKTFGCGSAIASSSLATEWVKGKTVAEALQISNTDIVKELALPPVKIHCSVLAEDAIRAAIGDWKKKNNVAETEGAAVAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW12</accession>
    <name>E8WW12_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67318">
        <property type="protein sequence ID" value="ADW67318"/>
        <property type="gene ID" value="AciX9_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0244"/>
    <dbReference type="eggNOG" id="COG3558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530444_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19557" checksum="46AB37FA79A4C091" modified="2011-04-05" version="1">MNDNLPRLVLKEFTVRLKAIFLAAILTTALPWATAQQPTPDEAAIRSVLAHEAEGWNKFDPHEVASVFTADAIWQNPFGVRLHGRAEIEKFLTDLLARPGYRAGTSTVPTKILDLRLTSPTTAAVWSDEKIEGLVNDISGNPMQPRHSYYLNVMVKQNGEWKISDAIIMDIVHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW63</accession>
    <name>E8WW63_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase (SpoU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0297</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578697.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0297"/>
    <dbReference type="EnsemblBacteria" id="ADW67369">
        <property type="protein sequence ID" value="ADW67369"/>
        <property type="gene ID" value="AciX9_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0297"/>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_0_1_0"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="OrthoDB" id="1637132at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="27733" checksum="4F3F960553BBC356" modified="2011-04-05" version="1">MPQGPPALDSTIDQSRVVVVLVRARNPSNIGAVARAMHDLGFAHLRIVNDFPVPFAAAKSAVDASSVLAAATEPASVAEAVADCTLVLGTTAVGERALQHPLQTLNQAAATVRQTLRTDPAAKIALLFGSEKTGLSNEELSHCHALLTIPMNTLTADHHLSMNLGQAAAVCLYQLALGDETLTPPAPPTETPAAAADLERLTSLLQQVLDDSGYTRRHPANSREPNVRRLVRRMALSADDAPVWTGILRQLLHALKPGSEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW79</accession>
    <name>E8WW79_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1403</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1403"/>
    <dbReference type="EnsemblBacteria" id="ADW68462">
        <property type="protein sequence ID" value="ADW68462"/>
        <property type="gene ID" value="AciX9_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1403"/>
    <dbReference type="eggNOG" id="ENOG502Z7R2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703792_0_0_0"/>
    <dbReference type="OMA" id="SAPFDDW"/>
    <dbReference type="OrthoDB" id="619892at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="43264" checksum="70AD598BA3E57EA7" modified="2011-04-05" version="1">MSTSVVSFPNSASIPAVAASAQQGVPWTIWAGVLAVTSASFGGAWDVAWHRSIGRDSFLTPAHIAIYACGVIAAVVCGYLILATTFSKSQQMKDVSVQVLGFRAPLGAFIAAWGGIAMLTSAPFDNWWHNAYGLDVKIISPPHTLLILGIRAVSFGVLFLILAAMNRAESVGEETGSTHKTLQRLFLYMGGLMVVGQMFFLLEQTFDVGLHRMVPYIAMAVALPAVFALLSRTTRHPWAATIASAIYMVISIGEILIFPLVPASPKLGPVFFPVTHLIPTKFPVLIIVPAIALDLLFRRAKSWKAWQIALAAGALFTVILFAVEWPFASFLLSKASENRFFGTMYFDYNSRPDGPDRLREFIDVARGAAIPIGLAVAAVCGAVSTWIGLRFGGWMRGVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW84</accession>
    <name>E8WW84_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1409</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579789.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1409"/>
    <dbReference type="EnsemblBacteria" id="ADW68467">
        <property type="protein sequence ID" value="ADW68467"/>
        <property type="gene ID" value="AciX9_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1409"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_1_0"/>
    <dbReference type="OMA" id="ENHMYYS"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="22553" checksum="65C953F9A88703C8" modified="2011-04-05" version="1">MAAPSWRSALEEYIRREAQPPEKFGHQPRLYELTRQIGQGIAYDDEVVCAAVWLHDLGVFTGHRPEDLEELKRWDNTAYAIAKAPALLNSFGFPQHKIPAVLECIRTHQPSFSPESIEATILRDADILEQLGAVGILRTVCKVGRDTRFATFTQAAASLQKALDTLPALLLLPASRALAEDRIHIHRAFLQAVTVEAQDSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB9</accession>
    <name>E8WWB9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579823.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1449"/>
    <dbReference type="EnsemblBacteria" id="ADW68502">
        <property type="protein sequence ID" value="ADW68502"/>
        <property type="gene ID" value="AciX9_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1449"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_0_3_0"/>
    <dbReference type="OMA" id="VPYKAYP"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="21135" checksum="C40325D9C5901FD1" modified="2011-04-05" version="1">MGYAIIGSGNVGKALATAFARKNLEVAIASRRSVELLEPIAKAIGPTIIPKALKDAVEADIIFLAIPFGTQKEVAKAARSWQGKIVIDVINAYGVSPEELEDLPSSVVVSHSFPGATLVKAFNHLPAEVLAQDPKVKDGRRVVFLSSDDESAADKVATLVERLGFAPVKLGKLTEGGLLVQARGKTWAQLIFQDFVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE5</accession>
    <name>E8WWE5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580924.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2584"/>
    <dbReference type="EnsemblBacteria" id="ADW69609">
        <property type="protein sequence ID" value="ADW69609"/>
        <property type="gene ID" value="AciX9_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2584"/>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132024_0_0_0"/>
    <dbReference type="OMA" id="TECRTEL"/>
    <dbReference type="OrthoDB" id="1850977at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19140" checksum="1E34CAF8C27B6D07" modified="2011-04-05" version="1">MNCTDFQNELPDLILTPGAKPSLAAVAHLKECPPCTEEYLSFQQTFAVLDTWTAPEPSPYFDQKMQVRLREEQAAPKMGWFESVMTRLQLNTGRQFRPAMIGALSLALIVGGGSFAGLNYNASHQQPAQASATINDLQILDRNEQAFEQLDQLQQDEDNQPTDDSGTPVQPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG1</accession>
    <name>E8WWG1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2600</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580940.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2600"/>
    <dbReference type="EnsemblBacteria" id="ADW69625">
        <property type="protein sequence ID" value="ADW69625"/>
        <property type="gene ID" value="AciX9_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2600"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_0_0"/>
    <dbReference type="OMA" id="VFGDMCD"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="35405" checksum="B31D6BC0823FECE7" modified="2011-04-05" version="1">MSGGPQNGAWRKASGQERLEFAFLWVIVKGLGLLPRPIARQMGVWIGRLAFRLVQKLRKVGLRNLELAYPERDSEWRSGTLVGLYRSLGLLMAEFCLMSGYTREQASEFIEYDGLEHFLAARDRGKGVLVLTGHLGAWELSSFYHSLMGYPMGLVIRRLDNPLVDAFVNRIRCLHGNRVIHKDDFARGLIAAMRNGETMGILMDTNMTPPQGVFVPFFGREACTASGLAKVAMKTDAAVLPGFLLWDEARRKYRLCFGEPMTLIRTENADADVLANTAAFTATIERYVRQHPEQWLWLHRRWKTRPAGEAGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL8</accession>
    <name>E8WWL8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3763</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582071.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3763"/>
    <dbReference type="EnsemblBacteria" id="ADW70763">
        <property type="protein sequence ID" value="ADW70763"/>
        <property type="gene ID" value="AciX9_3763"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3763"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_0_0_0"/>
    <dbReference type="OMA" id="YLRHTHE"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18790" checksum="2F35456FBF29C0DB" modified="2011-04-05" version="1">MFRLKESVHVNAPMDRCFLLSTSIELVQKTIGLKPVEGKTKGLIVSGDQLIWRGWKFGIPAMHETLITGYDRPAFFQDTMGRGRFSFFQHDHHFAEMNGCTTMWDIVRFSMPLGMPGKLVGKHIVVPHVLKLMLQRFELLKHIAEGSDWERYLVAAPASTESTSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX18</accession>
    <name>E8WX18_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1526</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579898.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1526"/>
    <dbReference type="EnsemblBacteria" id="ADW68579">
        <property type="protein sequence ID" value="ADW68579"/>
        <property type="gene ID" value="AciX9_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1526"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_2_1_0"/>
    <dbReference type="OMA" id="TIMFSRT"/>
    <dbReference type="OrthoDB" id="2034545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="10710" checksum="D2012525B8790E83" modified="2011-04-05" version="1">MSFLLYLLVALHVIVSLFLIGVVLLQTGKSADLAGAFGGQGSQTAFGPRGAANVLTKLTAYSTVIFMILSFSLTIMFSRTSSRDHSVLSGTPTQQSAPASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX59</accession>
    <name>E8WX59_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2677</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581016.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2677"/>
    <dbReference type="EnsemblBacteria" id="ADW69701">
        <property type="protein sequence ID" value="ADW69701"/>
        <property type="gene ID" value="AciX9_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2677"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_0_0_0"/>
    <dbReference type="OMA" id="INDMCSA"/>
    <dbReference type="OrthoDB" id="1465822at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230025" evidence="1">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="34659" checksum="CAC41A96D88059C7" modified="2011-04-05" version="1">MLSSVRSFLTAALLLPLPVLAQSFPPLKVETHLIDTTVSVHDGSGGLVNDVAKDDLTIIEDGVPQTVRFFSHADQLNLSIGLVIDASGSQEKFIKEHEHDIADFLHQTLLPGDRVFAVCFGNHLRLVSDWTGDQAAIIDNLRSYDKGHRDGPELGPIEEREFGTALNDAIFYSATEKMADVHQRRKVLVVFSDGEENSSEHDLVDAIEAAQNNDVLVYAIRYTELNHGKMNARDRYGMRELDHLTAQTGGKSYDVHAMKVSQAFAEIAGELRSLYGVAYQSTNKVRDGAFRKIVIQPNRPGLVLRARAGYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX92</accession>
    <name>E8WX92_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ordered locus">AciX9_2710</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581049.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2710"/>
    <dbReference type="EnsemblBacteria" id="ADW69734">
        <property type="protein sequence ID" value="ADW69734"/>
        <property type="gene ID" value="AciX9_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2710"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_0"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="179"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="37474" checksum="26C084FB02F548D9" modified="2011-04-05" version="1">MKVLIAGGGTGGHVIPGLAIARELRDTAGAEVRFVGTARGLETKLVPEAGFSLELIHVGQLKGVSLATRLRTLGDLPLGIAKCVAMLREFKPDVVVGVGGYASGPAMMAALLLRVPTVAYEPNAVPGLTNKLVGKFVSAAAVSYAQTTKYFRNATVTGVPVRATIFDVAPLTEAQTPRLLITAGSQGAKIFNDTMPLILSRLLEAVPGLTILHQAGARHIEATTAAFAASGADPSRWEVRAFIDDMPHQYAACTLVLARSGSTVAELAASGRPSLLVPFPQAADDHQRKNAEVLVQAGAATMMIQAGLTPEGLLEELTRMLNDAPGLVEMGANARTLAHPGALERIAGMALRVSRKTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX96</accession>
    <name>E8WX96_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2714"/>
    <dbReference type="EnsemblBacteria" id="ADW69738">
        <property type="protein sequence ID" value="ADW69738"/>
        <property type="gene ID" value="AciX9_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2714"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_0_1_0"/>
    <dbReference type="OMA" id="TGMSMLY"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015535">
        <property type="term" value="F:fucose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005275">
        <property type="entry name" value="Lfuc_symporter_FucP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00885">
        <property type="entry name" value="fucP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="49545" checksum="A29CA8D8F478B541" modified="2011-04-05" version="1">MHLSPSTAPRTVRPGEELPLFDRRYAVPFFMVTALFFLWAMPNNLNDVLIRQFMKSFQISRLQAGLVQSAFYFGYFCISLPAALVLRRFGYRIGLVTGLLLYAIGCLLFWPAAQANSYNFFLFALFVIAAGLAFLETGAGSFITQLGDPATSERRLNLAQAFNPPGTIAGALIGTVFIFSGVEPGPADVQTMKSAGTYASFLHSETLRVITPYLVLGTVVFLFALALFRVKFPSPTLSQEQFPHEPRGPVTSLFRIPHFVSAVVAQFFYVGAQVGTWSFLIQYVLDYTHQPEKIAGYFLSGTLLLFALGRFVATALMKYVRPNRLMGFLALVNVLLLTVAIGFPGWIGLWALMLTSLCMSLMYPTIFALGLKQLGPDTTLGASVLVMSIVGGAVVTPAVGFVAERMHSTAWGFVVPLVSYLVVAWFAFIGSRVRITPAEIRREEALRVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF5</accession>
    <name>E8WXF5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578816.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0416"/>
    <dbReference type="EnsemblBacteria" id="ADW67488">
        <property type="protein sequence ID" value="ADW67488"/>
        <property type="gene ID" value="AciX9_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0416"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021206_0_0_0"/>
    <dbReference type="OMA" id="WIAEYPI"/>
    <dbReference type="OrthoDB" id="252974at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="676" mass="74101" checksum="21CAB06FDB474919" modified="2011-04-05" version="1">MTSNRLLYGVTIFTSAFLLFLVEPMAAKALLPILGGSSAVWITCLVFFQTMLLAGYLYAHWLSRGGPRHRLAHLILLAAAIVALALATHITPSGSSAHPILTIFRTLTITIGLPFLLLASTSPLLQVWLSRRESSTVPYRLFALSNLGSLLGLLAYPILIEPHLTLRAQHALWTAAFTLFAILSTLITTRSQSPTSTPIQSPTYIPTTPRTRLLWFLLPMTAAVQLAAVTAHLTSNVAAIPLLWMLPLAAYLLSFILAFETPRLYQRSIILRVLVIMIASLAWLLTKTDVSLPIGIAIPFFLIELFLAAFFAHAEAHKIRPSTPQESTLFYLLVAAGGVAGTFFVGILSPLLFRSNYDLALAFLLTSALAAYITWREAPAYRILWSAATLGMIALIVALHIAYARQALFQGRNFYGTLRVLRESSPAGPVRMLMNGTIQHGTQILDRPDLETTPTTYYAEDSGAGLAIRSIPTDHPRNIGVIGLGVGTLAAYGTPAYGGRPGDHIHFYEINPLVKPIASYWFWYMRNTQAQVAITEGDGRASLHAAPPQHFDVLVIDAFSGDAIPLHLLTIEAMQEYRRHLAPGGVLAFHVSNQYLNLAPEIAALAQAVNMTPRRIESPAQPQRGEYLATWVLAADTPTYFDQPLLATHTTPIATTLKPWTDDYSALLPVVEWGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF6</accession>
    <name>E8WXF6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578817.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0417"/>
    <dbReference type="EnsemblBacteria" id="ADW67489">
        <property type="protein sequence ID" value="ADW67489"/>
        <property type="gene ID" value="AciX9_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0417"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071828_0_0_0"/>
    <dbReference type="OMA" id="QYTIAPV"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234142" evidence="1">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="299" mass="33577" checksum="076D11347202A508" modified="2011-04-05" version="1">MRCWAVVLLGFICLGAASGQQMAITFDDLPAHGSLPPHETRLQVAESILKTLEAEKMPPVYGFINAVGVSSTPKEEVVLKAWRAAGQPLGNHTWSHPSLEAVSAGAFEQEIAKNEPMLKKYMDGQDWHWFRYPFLYEGETLEKRRAVRGWLAGHGYRIAEVNMDFGDYLWNDPYARCSAKGDKAAITRLHDSYLATADEYVGVFRKASAMVYGRDVKYILLMHIGAFDARMLPELLALYRARGFSFISLEEAEKDPAYADDPDIGVRGGGAQVELMMAKKKLRFPANHKPDKELEKMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG3</accession>
    <name>E8WXG3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0424</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0424"/>
    <dbReference type="EnsemblBacteria" id="ADW67496">
        <property type="protein sequence ID" value="ADW67496"/>
        <property type="gene ID" value="AciX9_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0424"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_3_2_0"/>
    <dbReference type="OMA" id="TGMTKSY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="267" mass="29453" checksum="67A896132025D7DE" modified="2011-04-05" version="1">MSLKTEFPVPESLAPINPLPEPQADNSAIQVDGEAAESFIAEKRIGERIKYLRLKKSMGLVELGRHTGLSASFLSQLETGRVVPTLRNLARIAMVFSKDLNFFFEPEPQTLFRVHRAKDRVRLPQTGVTDPAYFFESLGYMVPDRQLDPYFAEFLAGKNDREPRAHQHVGCEFLYLLTGQLDVQHGEVTHHVEAGDAIYFDATTIHSYKCTGDASATALIVTLQQPVGGQQQGRPNGFVSARTRAAAAASVNGPRITDVMGSRKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI5</accession>
    <name>E8WXI5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ordered locus">AciX9_1548</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579920.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1548"/>
    <dbReference type="EnsemblBacteria" id="ADW68601">
        <property type="protein sequence ID" value="ADW68601"/>
        <property type="gene ID" value="AciX9_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1548"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_0"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="34242" checksum="8E779A914FE5C329" modified="2011-04-05" version="1">MNEYEVLADGFLAMLRNERGASEHTVRAYTREVKDFAAYLAGEMGERGIGAVEHLHIRGYLSVLYARGLEKSSMARALASVRSWFKWLAKEGKVEQNPALLVSTPKRAQHLPRVPSAEEVNRVMDSLESADGGTWPERDRVIFELLYGCGIRNSELCGLDMGNVQWANDAVLVRGKGKKERLVPLGDEAAAAVRAYMPQRAERLAAAGKGGLIGDGALLMNARMRGTCRLTTRSVGRIVKAIAQSRGLAADVHPHTLRHAFGTHMLEDGADLRAIQEMLGHERLSTTQRYTQLTVGQVQRVYEESHPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ5</accession>
    <name>E8WXQ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2726</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581065.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2726"/>
    <dbReference type="EnsemblBacteria" id="ADW69750">
        <property type="protein sequence ID" value="ADW69750"/>
        <property type="gene ID" value="AciX9_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2726"/>
    <dbReference type="eggNOG" id="ENOG5032SI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138456_0_0_0"/>
    <dbReference type="OMA" id="AGVLVYC"/>
    <dbReference type="OrthoDB" id="1779307at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="14433" checksum="AFE024883EC02655" modified="2011-04-05" version="1">MHTNASFDYAVLRVVPRVERGEFINVGVILLCREKRFLGAKVHVDEQRLRALWPQLDLDAIREHIEAVNRICTGDESAGPIAKLSQSERFHWLTSPRSTVMQTSPVHTGLCTETEALLDRLYHQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV2</accession>
    <name>E8WXV2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNARE associated Golgi protein-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2773</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581112.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2773"/>
    <dbReference type="EnsemblBacteria" id="ADW69797">
        <property type="protein sequence ID" value="ADW69797"/>
        <property type="gene ID" value="AciX9_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2773"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099466_1_0_0"/>
    <dbReference type="OMA" id="WVESHAL"/>
    <dbReference type="OrthoDB" id="1739862at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="25346" checksum="1A2C75DF6A4F4207" modified="2011-04-05" version="1">MLAGIPISRALALLSLATLAGSSSHLLHLVLSFGLFGLFLVSIVDSSFVPLPLPGITDIMVILFAAQHANLFLLIAAATIGSALGGLFSYQVGQSGGLDFIEKRTPPRIFKRVTGWMESHAILAVAVPALLPPPMPLSPFVLAAGALKMSRKKFMWAFTLSRLIRHAFAAWLGVHYGKAVLVLWNAFIRRWGAPVLIILWVAILGSVAFAFWRLWKTSHEVGLKQTKPLNATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV5</accession>
    <name>E8WXV5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2777</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581115.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2777"/>
    <dbReference type="EnsemblBacteria" id="ADW69800">
        <property type="protein sequence ID" value="ADW69800"/>
        <property type="gene ID" value="AciX9_2777"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2777"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_0"/>
    <dbReference type="OMA" id="YISLHEA"/>
    <dbReference type="OrthoDB" id="1668114at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14264" checksum="6AA48D9D9E9F7B77" modified="2011-04-05" version="1">MLTEAHIRDALRDCYDPEIPLNIVELGLVEYISLHEAPDAPGSGIEGVPARYLAKIVLIPTTRDDAPEAQLKAQVSNRLAAFFELWSVEVSIVDQPVWTPERITPAGRRTLGLDKPQFPILNNKVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ9</accession>
    <name>E8WXZ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578866.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0466"/>
    <dbReference type="EnsemblBacteria" id="ADW67538">
        <property type="protein sequence ID" value="ADW67538"/>
        <property type="gene ID" value="AciX9_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0466"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_4_1_0"/>
    <dbReference type="OMA" id="HDERVIT"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="100"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="49079" checksum="F77269D67B85319C" modified="2011-04-05" version="1">MPENVLQMTGPKAIIPQVAIRTASGALGEAASNQLKTAVHHELIKRMDLEKLAGMSSDPNGKQKLLVTISQLVGEQNIPLTGSDRERIAKEVMDEVFGLGPLEPLLHDSTVSDILVNTYDTVYVERRGVIEKTDVVFRDNAHLMHIIDKIVSAVGRRIDESSPMVDARLLDGSRVNIVIPPLAVDGPLISIRKFGSTPLTADDLLRNRALTPHMLEILKGAVKARLNIVVSGGTGSGKTTLLNVLSGYISPDERILTIEDSAELQIKQQHVARLECRPPNVEGKGAIKQRELVINALRMRPDRIILGEIRGEEALDMLQAMNTGHDGSITTIHANNPRDAIARLETMAMMGSVALPEKAIRAQIASAVHLIVQASRMSDGSRRITHISEITGATTEVVSMQDIFLFEKQGLGAANKVKGRFYATGIVPKFAEKLKAAGIPLGLNMMDQSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD4</accession>
    <name>E8WYD4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U61 LD-carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2817</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2817"/>
    <dbReference type="MEROPS" id="S66.001"/>
    <dbReference type="EnsemblBacteria" id="ADW69840">
        <property type="protein sequence ID" value="ADW69840"/>
        <property type="gene ID" value="AciX9_2817"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2817"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_0"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="175"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="32387" checksum="F9860EB5038AA4C9" modified="2011-04-05" version="1">MIKPKALKKGSLLAVVSPASTPKAELVAAGVARLEGLGYRVRVSAHALDKGPLYYAGTVEDRLADLHAAFADPEVDGIVCARGGWGSAELLPGLDKELIRTNPKVFVGYSDLTSFQTWLWNEIGLVSFYAPMVAADFSRLDAAEMGSWESALGGAEEWSVGAAEGLRVLRPGKAEGVLTGGCLSIYAEALGTPYAAKAEGGILFLEDIGTKPYQWDRMLVHLRYAGMLKDVTGIVFGDMEQNGADAEIEASILHALREFEGPIGFGLRSGHVSVANVTLPLGVKVRLDLTGEPELRFVEAAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH0</accession>
    <name>E8WYH0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">AciX9_2853</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581191.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2853"/>
    <dbReference type="EnsemblBacteria" id="ADW69876">
        <property type="protein sequence ID" value="ADW69876"/>
        <property type="gene ID" value="AciX9_2853"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2853"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_1_0_0"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="31572" checksum="BF6F4965A02C71C8" modified="2011-04-05" version="1">MALVPDAPIAPGLYLVATPIGNLEDITLRALRVLRQADRIACEDTRTTSKLLHHYAIETPTISYHLFNEQSRTAELIADLQAGAKIAIVSDAGTPGIADPGAPLVVAAVAAGIDVFPIPGPNAALSALIASGLPAESFTFHGFLPSKSGQRRSQLESLPRGPITHIFYESPHRILETLADISSIFTPSQPVVLARELTKLHEEFLRLPVSEALASLAARPQVRGEFVLLLHLPIAVGTAEVRPQTIAQAVKALMKLESIPEMDALKRVARDRGIGKSEAYREFQRETSRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH3</accession>
    <name>E8WYH3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2856</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581194.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2856"/>
    <dbReference type="EnsemblBacteria" id="ADW69879">
        <property type="protein sequence ID" value="ADW69879"/>
        <property type="gene ID" value="AciX9_2856"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2856"/>
    <dbReference type="eggNOG" id="ENOG502ZPHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400755_0_0_0"/>
    <dbReference type="OMA" id="IAPARQF"/>
    <dbReference type="OrthoDB" id="1469643at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="196" mass="21071" checksum="A229154976F1B77C" modified="2011-04-05" version="1">MTSPSTWTAQILTTPPLIAPARHFIYPQQIPGEEDALARGALNLLIQPVQGGTYLITCALGFKDPSLPTAIHPCPNPDEICAIAGGYAYLSNTLHPETCTLLPLKPVVEFHQTPEALIFIGFHTIIAWGREGLLWQTFRLSYEGLKVTAVTETLIEGLGWDLMTDKEIPFAVDLATGHHSGGAFPPSATSSTAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW1</accession>
    <name>E8WYW1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1749</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1749"/>
    <dbReference type="EnsemblBacteria" id="ADW68797">
        <property type="protein sequence ID" value="ADW68797"/>
        <property type="gene ID" value="AciX9_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1749"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666933_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="45851" checksum="EC6F09281BF094F8" modified="2011-04-05" version="1">MKIRLAFNETASGRFMVMSEMVRPGLSLNLERPLVTIFEDEDEFLKSVINADLFHEDTTAVVVTVLQSISQPVFPQRWIAIDVTTAQLKALGLFSHLMESDADQGYAAISPTLESPFEFTGGGHFQDFLMQVPTPILMLEGQEHLVTFINPPYVRLLGRTTSKSLLGKPIREALPELKGQPFFGLLDKVYRTGTAHVGVEVLGNLRHEDTGRTQDIYVDFIYQSVRNEVGEVFGIMVQASDATDRVLARQVSESREDQLYRQWAELDTIYRTAPVGMCLIDAADYRVLRVNNKLAHFTGQTASALVGMCILDIFPGTPGLKALFDKVRAGFSIENHELSCAVPSVPGILRHWLVNYGPMFGTDGNVEAITCVSQEITDRLLRDETFEKGETVVSRDTLQVPSMTMEPTAEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX6</accession>
    <name>E8WYX6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CMP/dCMP deaminase zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2868</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581206.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2868"/>
    <dbReference type="EnsemblBacteria" id="ADW69891">
        <property type="protein sequence ID" value="ADW69891"/>
        <property type="gene ID" value="AciX9_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2868"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_5_2_0"/>
    <dbReference type="OMA" id="MCHAAMR"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="17496" checksum="AA37838E601FA4E2" modified="2011-04-05" version="1">MTLPPDHDKFMQQAIDLATQNVLSGRGGPFGAVIVRAGEVIATGINLVTATNDPTAHAEVTAIRNACAHLSTFELRGATLYSSCEPCPMCLTAILWSRIDTLYFGSTATDAAEAGFDDSFFYQQVRLPTFDRDLPTTNILRTEALAPFNAWRTFTARIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ56</accession>
    <name>E8WZ56_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0587</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0587"/>
    <dbReference type="EnsemblBacteria" id="ADW67658">
        <property type="protein sequence ID" value="ADW67658"/>
        <property type="gene ID" value="AciX9_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0587"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011447_2_1_0"/>
    <dbReference type="OMA" id="RIEGNSA"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="464"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="647"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="745"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="989" mass="104590" checksum="8773D7C8C0C2A704" modified="2011-04-05" version="1">MISAHLFLLRSRQAGLGLICCVALSTWNAKLTAQTLQAPAASGQNAGSTAGSTANGSFAGVDGTVSPIAGTRGSLSAGQIVAILQDKPEVIVEIKQLAADQLQQQGVKIQPDSITDEALYSQIASNAPLRSAITNFLRARGYVSDADLQQNAAAGGSDRDDDGDALSSTQTLQSLSQVPGANLPLAAADGSSLQDSLAQQAEQGRLQSSGNTTGAGARTTNAAASRQTRDSDTHNTTDVPKVLRQPAPYNLLSMRDLYTQIPEESTHLKRFGSEMFVSRGGTGTMTRAVGQGQESPLDIPIGPDYVVGPGDSLSIDLWGGISQTLTKTIDREGRISLPEAGTIAVAGLTLERAQAVIGNTLKAQYRNAQVAVTVSRLRTVRVYVVGDVQRPGAYDISSLSTPLNALYAAGGPTGVGSLRTLRHMRGKELVAEIDLYDFLLHGVRTGDDRFQGGDTLLVPPAGPQVALSGAVKRPAIYELKHEATLAAVLADAGGSTVAAALSHITVERIDANQHRETVTLNLTKSSTGEAATAAISDFPVRDGDRIQIAPILPFSERAVYLEGHVVRPGRMAYREGMHLNDVLRSYQDLLPEPAAQGEVIRLVAPDLHAETIEFNVADALIGNVSLELQPFDTIRVLGRYDVDSPRVEIRGEVLRPGSFPLSEGMTAAQLVRMAGGFRRGALQQDADLTSYHIVDGNKVIGQRSAIRIGDAVARNDSSADVVLKPGDILTVHQITGWNDIGASLTIEGEANHPGSYGFQEGERLSSVLRRAGGLRDTAYPAGAVLIREQVRELEEKSRAELIHQIETSSAAAKLAPNLSGGDSSATLQLIQQQQEQVLARLRSQPSSGRLVIHINSDIDSWANTDADIEVRRGDVLSIPKRPGFVLISGQVYNASAITYVPGKTAGWYLQRAGGSSELADRKEIFVIRANGLVVGRHSGDGHVLSAKLDAGDVVVVPQKIIGTSQFWRNLLTVAQIASSAAIAAAVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ79</accession>
    <name>E8WZ79_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0610</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579009.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0610"/>
    <dbReference type="EnsemblBacteria" id="ADW67681">
        <property type="protein sequence ID" value="ADW67681"/>
        <property type="gene ID" value="AciX9_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0610"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_2_0_0"/>
    <dbReference type="OMA" id="KLGDWEL"/>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233513" evidence="3">
        <location>
            <begin position="25"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="95"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="385" mass="42628" checksum="4323C0C3A942D2BE" modified="2011-04-05" version="1">MLAPAFLKPILAALCLTTALIAQAPTTPMPPKLTPERHTYILHNFKTESGAVVPELTLVYGTYGHLNADRSNAMLLPSHYMAKLTGYEWLMGPNRALDPNQLFLVTSELFGNGSSSSPSNTPEPFHGPRFPIMTIRDNVVAVHQMLTEELKISHLKAIIGFSMGAQQAFQWAVSYPTFADRIVATSGTARTWPHGIVRLEGQIAALTTDPVFNNGDYTQPPQKGIEAFSVVWAGWLFSQEWWRKELWRSNNPPGTTFPQVLEHYRTHFIPGADANNLILQMRTWEHHDVGTTPGFNGDTEKALRSIQVPFLYMPSATDMYFPLEDARYEAQFIPKVSLVPIPSLWGHTAGAASNPADGKFLNETITRFLAGQSVTPPTTAVQAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE7</accession>
    <name>E8WZE7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1787</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580154.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1787"/>
    <dbReference type="EnsemblBacteria" id="ADW68835">
        <property type="protein sequence ID" value="ADW68835"/>
        <property type="gene ID" value="AciX9_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1787"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785957_0_0_0"/>
    <dbReference type="OMA" id="VRPCFLV"/>
    <dbReference type="OrthoDB" id="1776544at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14521" checksum="B8174D647AB74B3D" modified="2011-04-05" version="1">MVRPCFLVIDREHSGSISTRKLVIETAKFNVITAYSSPEAIETLKAFPALSGIVLDAGIKDMPCPELVEALKQIKPTIPIVAVGTPRVESCGPADHFLHSFDPAPLLLLLKNLIPEQAEAIERHNEKLALNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ4</accession>
    <name>E8WZJ4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ordered locus">AciX9_2945</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581283.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2945"/>
    <dbReference type="EnsemblBacteria" id="ADW69968">
        <property type="protein sequence ID" value="ADW69968"/>
        <property type="gene ID" value="AciX9_2945"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2945"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_0"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="123" mass="13279" checksum="1BE2ADB99CB1444A" modified="2011-04-05" version="1">MSVQMRTMLEVADNSGARKLQVILPLGGGLGKKAGLGDVVTAAVKEASPDGTVKKGKVVKAVIVRTRKEYRRRDGTYIRFDSNAAVVVNDGMEPVGTRVFGPVARELREKKFLKIVSLAPEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU9</accession>
    <name>E8WZU9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0690</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579088.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0690"/>
    <dbReference type="EnsemblBacteria" id="ADW67760">
        <property type="protein sequence ID" value="ADW67760"/>
        <property type="gene ID" value="AciX9_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0690"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="25333" checksum="764221FF6C7112D7" modified="2011-04-05" version="1">MSKLSGKVAIVTGASKGIGASIAEHLAAEGASVVVNYSSSKSGADAVVERITKAGGKAIAVGANVAKPEEIAKLISETVKAYGKINVLVNNAGIYDFAPLEAITPEHFHKQFDLNVLGLLLTTQAAVKEFPEEGGSIINISSVVGKSAQPNAAVYSATKGAVDAVTLSLARELGPKKIRVNSVSPGLVETEGTAGFMGSDFHKTIEAQTPLGRIGQPDDIGKVVAFFASDDSTWISGEAVLVAGGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV7</accession>
    <name>E8WZV7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0698</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579096.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0698"/>
    <dbReference type="EnsemblBacteria" id="ADW67768">
        <property type="protein sequence ID" value="ADW67768"/>
        <property type="gene ID" value="AciX9_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0698"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_0"/>
    <dbReference type="OMA" id="TIAVESW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="526" mass="57240" checksum="F98F563D40AC97E5" modified="2011-04-05" version="1">MPPQKLDPETIADSNSGSRPGHLRVLLVEDNPDDAFLLERHLRRNGFSLDLTRVETASEMLRALDPPNVPDIIIADYNLPKFSGPAALQLIKSSGADIPFIMMSGAISEETAVESMRAGAQDYVTKQNLARLVPILDRELREASARRKKVQAEEALEASQARFHRLVEAMPLGLLIGDATDRIVYANGAVERLLGYSNGSMLSGDITLDSICPTLRAAYNEDLGNTNSFAAAPFETACVTANGTQIEVLLGVALLNPEAAPADRQIAAFIADLTLQKKSEEVLRRTEKLAVAGRLAASIAHEINNPLEAITNCLYLVGKTELPPDARTYLALAQDELDRVAQITVQTLRFYRRSTHAADTNLHDLIETVAALLGSRMNRQRITLVRKFGEIPPIFAHDGEIRQVLANLVGNAIDALPNGGVITLRTGLSRDWKTGRTGIRISVADDGTGMSQATLNRIFEPFFSTKGITGTGLGLWVSREIIDKHKGTLRARSRERREGCPGGTVFSLFIPSELAEAELADVPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X017</accession>
    <name>E8X017_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1867</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580232.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1867"/>
    <dbReference type="EnsemblBacteria" id="ADW68913">
        <property type="protein sequence ID" value="ADW68913"/>
        <property type="gene ID" value="AciX9_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1867"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_2_0"/>
    <dbReference type="OMA" id="FGRWRYT"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="19746" checksum="640DC261E1FF9865" modified="2011-04-05" version="1">MFANIREDWRTHDSNWGRHGFWALVVYRFGRWRYSVGWRPLRAPLSFFYKLLKFFSDALFGIEMPCETVIGKRFVIEHVGGIVISGDAIFGDDCIVRNGVTVGLRHRGLRGSPQLGDRVDIGAGAKLLGPIRIGNDVSIGANAVVLCDVPDGCIAVGIPARIIPRKSAVDAALPLAAFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C2</accession>
    <name>E8X0C2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3083</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581417.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3083"/>
    <dbReference type="EnsemblBacteria" id="ADW70103">
        <property type="protein sequence ID" value="ADW70103"/>
        <property type="gene ID" value="AciX9_3083"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3083"/>
    <dbReference type="eggNOG" id="ENOG5033Y29">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1747070_0_0_0"/>
    <dbReference type="OMA" id="QHKFSDW"/>
    <dbReference type="OrthoDB" id="2097257at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16695" checksum="1B1B192D9EE84C59" modified="2011-04-05" version="1">MHATQKRLNEMNRLTDMLHFPALVNAGATLNVLITILATWYVEPRYPALAGLWIALVLTLNLLPVALLRLTLTPATPYPTLPQMNFVRDQHKFSDWVYLAASAGMAFWILLTWTVSACSRSPFTLVATLLAAFLITFSPVLLRPLFKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D4</accession>
    <name>E8X0D4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0728</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0728"/>
    <dbReference type="EnsemblBacteria" id="ADW67798">
        <property type="protein sequence ID" value="ADW67798"/>
        <property type="gene ID" value="AciX9_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0728"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046841_0_0_0"/>
    <dbReference type="OMA" id="FGYLIMM"/>
    <dbReference type="OrthoDB" id="1155696at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="413" mass="45227" checksum="469C1D19200B3D9E" modified="2011-04-05" version="1">MRRNLRNVGLIARREYLERIRTRAFLLATILIPLLMGGFVFGSGYLSTRTKSSAHVAIVSSDPVFSADLKQELTNGSKSSMTVDLLEPNPGVREGLSGRLKARNDLAGYLWVSPPADGSARPNFVYVPRSAGDIATQETLTNSIKDVLTRERLHKQGMGAAEIEDMMAPVEMDTSSTGSSKLAFGAAYVFFFLMYMVIMLYGMNTARSIIEEKTSRVFEVLLSTITPDEMLAGKILGVGAVGLTQIGVWMLAVGVLATTFAGMLPGGVSGHSVVSASQIAFFVAYFIFGFLLYSSIAAALGAMTNSEQELQQLNLFLVMPLAFCMLMIFVIVQAPNSTLARIVSLIPFCSPLLMNFRLSLTHVNPIEVVLSFVLMGLTIWGTLWLASRIYRVGILMYGKKPNLPEILRWLKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H2</accession>
    <name>E8X0H2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0767</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67836">
        <property type="protein sequence ID" value="ADW67836"/>
        <property type="gene ID" value="AciX9_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0767"/>
    <dbReference type="eggNOG" id="ENOG50330ZS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131976_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230523" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16982" checksum="33F6820F2397C9DC" modified="2011-04-05" version="1">MRMNLKWIAAAGMMAAMVPFAGAQQVPGPHPAYLHALSDLRAARHYLNDGWAWQPVKHDDNAAIREIDAAINEIKMAAIEDGKGVNDPFPIDAHVSPHDRFRKANELLWSAHNDLSKAEDVPQSRGLRDRAILHVDRAHGIVDNTERTAKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R5</accession>
    <name>E8X0R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC C subunit domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580335.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1970"/>
    <dbReference type="EnsemblBacteria" id="ADW69016">
        <property type="protein sequence ID" value="ADW69016"/>
        <property type="gene ID" value="AciX9_1970"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1970"/>
    <dbReference type="HOGENOM" id="CLU_1127816_0_0_0"/>
    <dbReference type="OrthoDB" id="2050675at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="27530" checksum="D10623689BFBC32F" modified="2011-04-05" version="1">MNYGTVYLIRNSINGKVYVGQTIRAVGQRFKDHLAAGRRAHPPYPIHRAIAKYGADSFTLCVLGVASCKAELDEMETRAIFTHEAQNRAFGYNLAPGGEGFSSERVKAHWADPQKRARHVASMLTKWADAAFKESVSAHRRITAGTPQARKNNSDAQLRADVVARKSRASKEQWNDPDFIKLKSDQAKAMWVDPEKRALNVAARNTPEARANRIASNKRMWAAPGFKEKQIEKMRLAKAAKRTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W4</accession>
    <name>E8X0W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3136</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581461.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3136"/>
    <dbReference type="EnsemblBacteria" id="ADW70148">
        <property type="protein sequence ID" value="ADW70148"/>
        <property type="gene ID" value="AciX9_3136"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3136"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_2_0"/>
    <dbReference type="OMA" id="IPRHTHH"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15910" checksum="A224B5A425893C10" modified="2011-04-05" version="1">MTEQKEFVLAGVVMKQQLSGADTNGSFSLFENRSGGQSKTPIHVHADDDETLFIIEGEMKAIIAGNEQTIKAGESIFLPRGIPHQLINSSGHPSHYMLLCTPSGFEGFLAEGGHLKGPDEVVGPPTPEDIERLKTAAPKFGITLLPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X6</accession>
    <name>E8X0X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3148</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3148"/>
    <dbReference type="EnsemblBacteria" id="ADW70160">
        <property type="protein sequence ID" value="ADW70160"/>
        <property type="gene ID" value="AciX9_3148"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3148"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114585_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="27722" checksum="53615C3FD1BE70F4" modified="2011-04-05" version="1">MAECRHHQVANSIVPAQKSKLFLIHDASRRPSRLAMVHRAGANALLPGPAWVEQDGKRVRIRLLDPRAESFITDETSEEATVATACVPPAQLAEDGLSPSQFRRVLAFIGDRLSRNLTLSELAREAGLSAAYFSQRFKCSTGTSPHQYLLRLRICKAKTLLEESESPIIDIAAECGFQTQQHFARIFRRLTRTTPTEYRRQRQQSHYASVAPTLLDRRHILSQDHQPPAGRGTLKSGSLDTLPGSAVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X7</accession>
    <name>E8X0X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3149</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581474.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3149"/>
    <dbReference type="EnsemblBacteria" id="ADW70161">
        <property type="protein sequence ID" value="ADW70161"/>
        <property type="gene ID" value="AciX9_3149"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3149"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OMA" id="ITGGRNW"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26112" checksum="6150B9D8F216AD38" modified="2011-04-05" version="1">MGRLSGKTALITGGNSGIGLATAKLMAQEGAKVFITGRRQEALTSALNEIGPLGVGIQGDVSKIADLTRLAAELTAQKVKLDILFANAGAGTVLPIADVTEEHYYQIFDTNVKGVVFTVQKLLPIMNDGGSIILNSSITESKGMEAFSMYSASKAAVRNFARGWANDLKSRKIRVNAISPGVVITPGYNGLGMNDDQIKEYAAQSSAKTPAGRTGQPEEIAKAVLFLGSDESSFVNAENLIVDGGFSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X117</accession>
    <name>E8X117_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0815</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579208.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0815"/>
    <dbReference type="EnsemblBacteria" id="ADW67883">
        <property type="protein sequence ID" value="ADW67883"/>
        <property type="gene ID" value="AciX9_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0815"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923667_0_0_0"/>
    <dbReference type="OMA" id="HAIKINA"/>
    <dbReference type="OrthoDB" id="1217192at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="301" mass="33066" checksum="5E16C7A053305C3A" modified="2011-04-05" version="1">MDTRRIITSLLIGFTALLALDPGLLGQGMRSAGDMAKLERHQMPDWLLLEPYLPDPRTATAARLELEGDVLRARRFDEDALEYYQFALNRGGDVPRLLNRIGITQLTLSQPAAARLYFAKVVALQPKVGAGWNNLGATEYFAGNYRSALTDYSRAVKFEKRNAVFHANLATAYFQLKDYESARREFAKAYKLDANVFRPDGGNGIQARVLSATERGRFCFELAKVAALGHDDVAVMAWLTKASEAGLDLGAEMVGARGLEAYRVDPRVLLLEQNAKAMGSSKRALASVAVPTLPAELSKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X166</accession>
    <name>E8X166_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579257.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0864"/>
    <dbReference type="EnsemblBacteria" id="ADW67932">
        <property type="protein sequence ID" value="ADW67932"/>
        <property type="gene ID" value="AciX9_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0864"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457684_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008715">
        <property type="entry name" value="SAM-MeTfrase_NodS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05401">
        <property type="entry name" value="NodS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="596" mass="65959" checksum="362FB77E6BA1FC63" modified="2011-04-05" version="1">MADVVEVGDERESLGDDLGEVRGGDDLGSLLRRATGLADELARRPNLGLQTAPKREIERFAEIGLLTAPLPVSEGGLGLGVEAGTQETLMRVLAAVGGADLALGRIYEGHVNGLLLVQRYGSAGQVARLAEEVRGGMISGVWNTGKPEVLRLVPEQGGYRFEGEKTFCTGAAFVQRPMVTAEIPGRGWQMTVPTMESLGASIDRSFWHPLGMESSESFGVDFTGGRVEADELIGAPGDFYRDPMFRGGAVRFAAVQAGAVMRLHVMFAEWLDEMRRGDDPYQVARLGEIAISAQEAAMWVEKGAAVCEESFYRTDKAHVERMIECANMMRVAIERLGTGVMQRVTTGVGAHGLLQPARFERVIRDLTMYLRQPAPDATLAAIGRYSLEKSHRRSEGSGDGFWRDGFREESLPPKYFERIYTQKRDPWEFETSEYEREKYGATVGALPEERYERGLEVGCSIGVLTKLLAERCDELVAVDVSETALRVAKGRCPGVSFACLRVPEEMPSGMFELIVVSEVAYYWSLADLARAADELAARHMDGGHLVLVHLTEWVPDYPLTGDQVHEYWLGRAEWKWVGGERRERFRIDVLERQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X181</accession>
    <name>E8X181_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1989</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580354.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69035">
        <property type="protein sequence ID" value="ADW69035"/>
        <property type="gene ID" value="AciX9_1989"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1989"/>
    <dbReference type="HOGENOM" id="CLU_2954054_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6870" checksum="D3A27098EB4BB74D" modified="2011-04-05" version="1">MNEAITLATRSFAEAIIQSHYAGVKRAEEFRMASLQHEDQQRKRYKADILKQINYLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X182</accession>
    <name>E8X182_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580355.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69036">
        <property type="protein sequence ID" value="ADW69036"/>
        <property type="gene ID" value="AciX9_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1990"/>
    <dbReference type="eggNOG" id="ENOG5032VSR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865652_0_0_0"/>
    <dbReference type="OrthoDB" id="1017528at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="35090" checksum="A6C1C3662817D218" modified="2011-04-05" version="1">MPRYAASNWGWVALTLIVGGTAAIISRAAFWQKKNEVAIRPPGVRLLLPPQPAQSIAAGDLPYALISCSAYDSLNPNDKKAKRCPNGSADLGDEWQPWIAFPDAELQTEMASVHLRARVWENKSKGLLVVSFGGTEAGSWNDWKSNFRWTQLWQKDEYTVLGSSYVRSFAEELARRRTQPGQEYLGKVTLISTGHSLGAGLAEKFAYSLPAREFGIQHVDTVFAFDTSPVTTFLNTARNVRQENVIGLKIVRIYERGEGLAIVRAIASVVHKPSTVNPEVSQRRYNLFGDDRFGTTNPVASHSIAELAEGLKKVAAGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E4</accession>
    <name>E8X1E4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose synthase operon protein YhjQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580415.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2053"/>
    <dbReference type="EnsemblBacteria" id="ADW69098">
        <property type="protein sequence ID" value="ADW69098"/>
        <property type="gene ID" value="AciX9_2053"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2053"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544725_0_0_0"/>
    <dbReference type="OMA" id="HEYPAEV"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017746">
        <property type="entry name" value="Cellulose_synthase_operon_BcsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06564">
        <property type="entry name" value="CBP_BcsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="577" mass="63481" checksum="8692F3F5EE0B8118" modified="2011-04-05" version="1">MEKYLNDNPEEPLAAETPEDVAILYSWANLHGAKYRDFSASRREYRAQVRHRAAEELRHAELQAAAEAERAAAEAEQIAREAERAAHNPMGDETYYPREQAILTAEEAARRASAERVEAARRAEAAAFAEAVARREEREIAEAHASAARQAARWAESDTRRRSLAGPQPSAVVPGLRGDPYMREQGSGPEVDLYTPNEQLERVLPNRYRGDDPNNPNATGRPYLPPETPGRRRPQGYRPDDASGIRPAYGSAAQPGAGYGAGQGGVTPAWLNSETQQPSVVPSSVDDTLQHSRERVASRWYGLKDAFEPGQEPVEEDGTERHRETRTPFLAVFSLAGGVGKTSMVATLGRSLSSLGEKVLLTDTTSHGLLPFYFGASELRAGVVRTFSPPSGSTDAPIYLVSYDVDEAAGDRTLQDALADEITKAASGTHRVLLDLNTASAWLIRRLIKMSPTILVPVAPDMNSVISLQAVERFFHGLNDQEGRAIQPYYLLNQFDAALPLHLDVREVLRRQLGDRLLPYVIRRSPAVSEALAEGMTVVDYAQDNAVAKDYLNVAHWLRSVSAPATQAFRNARWSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L9</accession>
    <name>E8X1L9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">htpG</name>
        <name evidence="7" type="ordered locus">AciX9_3243</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581566.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3243"/>
    <dbReference type="EnsemblBacteria" id="ADW70254">
        <property type="protein sequence ID" value="ADW70254"/>
        <property type="gene ID" value="AciX9_3243"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3243"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_0"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="547"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="621" mass="70629" checksum="D798DDFFB4234BEF" modified="2011-04-05" version="1">MSKREFQTEVSQLLQLIIHSLYSHPEIFLRELISNSSDALDKLRHLTLTDDVYKALPFDPRIDLELDEEGKTLTISDTGIGMNEEDLVSHLGTIARSGTKNFLSQLSGDAKKDSNLIGQFGVGFYSAFMVADKIEVVSRKAGEELAWRWISDGKTGFEITPAERLVAGTTVLLHFNEEGAQYANSYRLQEVVKKYSNHIAFPIFLTYDKSEWNEEEKKSDKKRTTEQVNAASALWRRPKSELKDEDYKELYKSVSGDWEDPLFWFHTKAEGSLDYTTLFYIPAKAPLDLYQAEYKVGVKLYVKRVFILDDSKDLLPQYLRFVRGIIDSEDLPLNVSREILQQNRVLTSIRTASVKKILSELKNIAANQPEKYETFIAEYNRPLKEGLHNDYANRETLLDLIRVKSTKVEGLTSLAEVKSRMKEDQKSIYYITSGAESLLRTSPLLEIYKKKDLEVLILDDDIDEIVFSGVDKYGEIDLKAVNKASTSEDLKDEAEPDQAEALKPLLDKLKATLGDRVKDVRASVRLADSPSCIVSDEEEPSLKMQQMLRAMGQKDIPVMRPTLEINPDHEIVKKLLARPDDATAEDAAWLLFDQALLMEGVPLQDPANFVQRLNRILNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q6</accession>
    <name>E8X1Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0908</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579299.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0908"/>
    <dbReference type="EnsemblBacteria" id="ADW67975">
        <property type="protein sequence ID" value="ADW67975"/>
        <property type="gene ID" value="AciX9_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0908"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073253_0_0_0"/>
    <dbReference type="OMA" id="VLECNHD"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37744" checksum="B00CF49765574BF8" modified="2011-04-05" version="1">MRMTVLASGSKGNSTVIASERTRVLVDAGLSCRELLRRMAVVGEDPEKLDAILITHEHLDHVAGLAVLARRLKIPVFFTEQTHRAWVRMLTPRTTMTYAKWLDQYQSQKEALKAKVPQYSVPGGAELESIAAVSAEAAVFDPVVNRSDDPNPTFELPVDDLEDCDPATPAKVKADPAYLPAVEYFVAGRQFSIGDLEICPFTIPHDASDPCGFVFESLGDGVRMALATDLGYMPPNVKAALKNVDVLLLESNHDLEMLKDGPYPWSVKQRVLSRVGHLSNDATAEFLATDYDGGAAYIVLGHLSESNNVPELARITAERAIGDRMTLLGNRVLLALQAAPLDPIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R9</accession>
    <name>E8X1R9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="10" type="ordered locus">AciX9_0921</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0921"/>
    <dbReference type="EnsemblBacteria" id="ADW67988">
        <property type="protein sequence ID" value="ADW67988"/>
        <property type="gene ID" value="AciX9_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0921"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_0_0"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="49"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="25595" checksum="AA12E7BAD42F1C9D" modified="2011-04-05" version="1">MAAQEMNPEEFLHEGEDLSLETPETPGAADVQPPVEAEGEHLAPPVNENFKWYIIHAYSGFERKVRESLESRIHAYNLQNRIGRIMIPTEPVTELRNGKKYTIERVFLPGYVLVEMELDNDLWHVIKNTPRVTGFLGTGDSPVALSEQEVSSILFRTDVSKDKPSMKIKFAKGEQVRINEGPFANFSGVVDDLNEDKQTLKVMVSIFGRSTPVEIEFSKVDKMEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S3</accession>
    <name>E8X1S3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0925</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0925"/>
    <dbReference type="EnsemblBacteria" id="ADW67992">
        <property type="protein sequence ID" value="ADW67992"/>
        <property type="gene ID" value="AciX9_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0925"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_3_0_0"/>
    <dbReference type="OMA" id="MTAYTIN"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="23227" checksum="F9A09945ED3C0292" modified="2011-04-05" version="1">MSDSTNVQTDINFALSSLPLPVRLRPGTPMNDLELMRFSRENRPLRMEREENGDILIMTPTGSRTGDMNHKIGMILGLWAEEDGRGVTFDSSTGFRLPNGAVRSPDASWLVNERWDAMTSEEQDGFGVCPDFIIELTLPSDRLPQVKKKIVEQWLPSGVSLVWLIDTESRTVAIFRPGEEPELLHDPSSVQGTGLVSGFELVMARIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T1</accession>
    <name>E8X1T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0933</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0933"/>
    <dbReference type="EnsemblBacteria" id="ADW68000">
        <property type="protein sequence ID" value="ADW68000"/>
        <property type="gene ID" value="AciX9_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0933"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3328446_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="38" mass="4256" checksum="5923620F6B74A2E6" modified="2011-04-05" version="1">MGATTAQVQQEVTAAIEAEERELEQMRMEGEQEEMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W6</accession>
    <name>E8X1W6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidyl-dipeptidase Dcp</fullName>
            <ecNumber evidence="9">3.4.15.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2083</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.5" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580444.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2083"/>
    <dbReference type="MEROPS" id="M03.005"/>
    <dbReference type="EnsemblBacteria" id="ADW69127">
        <property type="protein sequence ID" value="ADW69127"/>
        <property type="gene ID" value="AciX9_2083"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2083"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_4_0_0"/>
    <dbReference type="OMA" id="KRSGAWC"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="255"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="701" mass="77657" checksum="DFD509F3BD729156" modified="2011-04-05" version="1">MSVVLAAGAMAVGMAQGQTAVFGPANPFYEKSSLPFEAPPFDRIKDADYEPALMAGMEAQTKEVRAIADNAVPATFENTVVALEKTGLLLDRVQAALGGVTGAYTNPTLEQLQAKMAPKMSAHEDAIYLDAKLFKRVEAVYEKRAGLGLDAESLRLLEHTYDGFVHSGAKLNDADKAKLKAMNEEESKLSNTFGRRLLAATKAGAYTTTDKAALAGLPEAQIAAAAAAAKARGVEGYVLPLQNTTQQPVLSGLNVRATREAVFHDSWTRAEKGGDNDTRMIVSELAQIRAQKAKLLGYPTYAAWKLENQMAKTPEAAIHFMDALVPAAVAEAKAEQRDIQELIDTQKGGFTVQPWDWEFYSEQVRKARYDIDPEAVRPYFEIDNVLQNGVFYAANKLYGVTFQERHDLPVYAPDVRVFEVFNADHSHLAIFYCDYWKRDNKRGGAWMGSFVRQSRLLGEMPVVYNVANFTKPADGQPALITFDDVTTMFHEFGHALHGMFAAAQYPSLSGTSVPRDFVEFPSQFNEHWSTYPDVFQHYAKDYKTGAPMPEELAAKLKRAATFNQGYALTELLAAAELDMQWHTLGAGMPAQEADAFEKAALEKKSLALEAVPPRYRSTYFSHVFAGGYAAGYYAYLWSEMLDDAAYHWFEENGGLTRANGDRFRKMVLSRGNTEDLAKMYDTWLGGEPKIEPMLKQRGLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X220</accession>
    <name>E8X220_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">40-residue YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3252"/>
    <dbReference type="EnsemblBacteria" id="ADW70263">
        <property type="protein sequence ID" value="ADW70263"/>
        <property type="gene ID" value="AciX9_3252"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3252"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009318_3_0_0"/>
    <dbReference type="OMA" id="APGPHWF"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="358" mass="37676" checksum="0DAC7ECE035A4DD8" modified="2011-04-05" version="1">MRWKGLIAGLVMVGGMVPVMGAQESASGPMLLVLAKHDEMLSLVDPGTLKVVAKVPTGGNPHEVIASADGRTAWVTNYGNGSLHSIRVIDLMGRRVEKVIELGPIWGPHGLAFADGKVWFTAEREKLIGRIDPATEGVDWLMGTGQTGTHMLWVAKDASEIVTVNVGSGTMNLFTRNPVGTLQKAGGPPSKAGATTMHGDDPAPVPDWEQRIVKVGGLPEGFDVIPDAEGHAQTVWVANAKEGTVSVIDFATGQVTATIEAGVPTANRLKFTPDHRMALISREKSGELTFVDVASRKVLKRVMIGTGAAGVLVAPDGKRAYVSCSPDNDVVVVDLASMQVVGKIEAGMEPDGLAWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C4</accession>
    <name>E8X2C4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0989</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68056">
        <property type="protein sequence ID" value="ADW68056"/>
        <property type="gene ID" value="AciX9_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0989"/>
    <dbReference type="HOGENOM" id="CLU_2584807_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="8774" checksum="97933AE614D655FB" modified="2011-04-05" version="1">MKSKNIQLQEQLLGFFASLGMTVGVGVKVRRGGRRSFASANDTHPFGMKLRKDGAPAIAIYLALAGGTMPFMRRYSTIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J6</accession>
    <name>E8X2J6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2176</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580536.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2176"/>
    <dbReference type="EnsemblBacteria" id="ADW69220">
        <property type="protein sequence ID" value="ADW69220"/>
        <property type="gene ID" value="AciX9_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2176"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_1_2_0"/>
    <dbReference type="OMA" id="WERDVWR"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="360" mass="40428" checksum="BE9D13B4B9CC47AE" modified="2011-04-05" version="1">MATSTSFIPASDLLVADAPPRSVMPRDCTFTESDWRALAPFWYPVAFSREVTHQPYASRLLDERVVVYRLSDGTVAAARDICYHRGVPLSLGHVEGDEIICKYHGLRYDKEGRCVCIPAHPGGAISPRLHLDMYQAQERYGLVWVRLVDNGPLPLPEMKEWDEPGYLQVLPDSVLINASAGRQMEGFLDVSHFAFVHKDSFGEPDNPVVPDYKVTKTPQGFVADYISSVSNYSHGFKHLNPPGFQWHRRFEVFRPFVAKLTVEFPGGGLLHIMNAASPVSARKTRLFVPICRNFDLDAPIEATLDFNYQVFAEDIAIVEQQFPEDLPIDLQAEAHFPADRSSITYRKGLAEIGLGRTYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S8</accession>
    <name>E8X2S8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">AciX9_3367</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581687.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3367"/>
    <dbReference type="EnsemblBacteria" id="ADW70375">
        <property type="protein sequence ID" value="ADW70375"/>
        <property type="gene ID" value="AciX9_3367"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3367"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_0"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24360" checksum="BC0C0D38BBDE6720" modified="2011-04-05" version="1">MIELAFSILASDFAHLADEIATAERGGGTIVHVDVMDGHFVPNITFGPPVVAAIRPLTKLPLDCHLMIENPDSFIEDFAKAGADILCVHQEVCRHLHRTLQLIQQHGCQPAVVINPATPVETLIEVLPMLHHVLVMSVNPGFGGQKFLPLALDKIEHLAELREEMGLNFRIEVDGGVAHDTVARVVEAGADMLVAGSAIFAPGDPARTEQNAREFLRLARAAAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z7</accession>
    <name>E8X2Z7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase-related peroxidase</fullName>
            <ecNumber evidence="1">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1068</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an organic peroxide-dependent peroxidase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579454.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1068"/>
    <dbReference type="EnsemblBacteria" id="ADW68131">
        <property type="protein sequence ID" value="ADW68131"/>
        <property type="gene ID" value="AciX9_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1068"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045961_0_0_0"/>
    <dbReference type="OMA" id="KINHTKG"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000296">
        <property type="entry name" value="SrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0349">Heme</keyword>
    <keyword evidence="1 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000296-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000296-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="33942" checksum="BFBDBAC1BA92D29D" modified="2011-04-05" version="1">MPLPSDEKLVELGNELIKAFDGIFGLHPGFRPAHAKGVLLTGTFMPTAEAKALAPAPHFVQQATPVTVRFSDSTGLPQIPDTDGNANPRGMAIRFNLGEHVHTDIVAHSTDGFPTRTGGEFLEFLKAVATSGPDTPSPKPIEVFLGGHPAALKFVQTPKPFPVSFGTEDYFGVTAMQFTSEAGEVKFGRYQIVPKAGVARLSDDEVKAKGPNYSFDEIKERVAAGPVAFEVKLQVAGPGDVVDDATIHWPVERPVISLGTVVLDAVVADDAAEQQKIIFDPIPRCAGIEPSDDPLLELRAAIYLLSGRRRRAATQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X353</accession>
    <name>E8X353_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2235</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580593.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2235"/>
    <dbReference type="EnsemblBacteria" id="ADW69277">
        <property type="protein sequence ID" value="ADW69277"/>
        <property type="gene ID" value="AciX9_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2235"/>
    <dbReference type="eggNOG" id="COG4137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_0"/>
    <dbReference type="OMA" id="MPGEFIT"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="40"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="29900" checksum="B1BE8AAAA0E4FF54" modified="2011-04-05" version="1">MSLLWLRVAVLLYGIAALAVLPAALYDRHRWRHIAIPATVLALIFHFVSFAETLSAAHHALPVDTHETLSLIGILLALAFLIVYWRYRTLALGIFILPVVFLLGLLPAFHPGEELVAPGLHAGWVLLHIALLLAAYVALLISLIASLLYLIQERRLKSKSVAKSSIKLPPLDTLDRLALRALTLGLPCMTAGLLIGSALAQVTYGSAYFRDPKILLAFAMWLAYIGMIYIRRHSGLRGRRAVYLSSFTFFIILAVWASNQFSAVHRFTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X370</accession>
    <name>E8X370_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2256</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580610.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2256"/>
    <dbReference type="EnsemblBacteria" id="ADW69294">
        <property type="protein sequence ID" value="ADW69294"/>
        <property type="gene ID" value="AciX9_2256"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2256"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_0"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="35887" checksum="1D7A44DC0D6A6455" modified="2011-04-05" version="1">MAVKVGINGFGRIGRNVFRTALGNPEIEFVAVNDLTTPATLAHLLKYDSILGNLKNTISHGADYIEVDGKKIKVFAERDPSKLDWASVGAEIVVESTGFFTDAEKAKAHLGTTVKKVIISAPATNEDLTVVLGVNDDKYDASKHHVISNASCTTNCLAPVVKVLHDTFGIASGIMTTIHSYTNDQVILDTPHKDLRRARAAALSMIPSSTGAAKALKLVVPEMAGKLDGFAIRVPTPNVSVVDLTFVAEKPISVETINAAIKAASEAGPMVGILGFTDEELVSTDFRGDSRSSIFDSKLTKVVGQTGKVISWYDNEWGYSSRVKDLVLFLVEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X373</accession>
    <name>E8X373_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2259</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580613.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2259"/>
    <dbReference type="EnsemblBacteria" id="ADW69297">
        <property type="protein sequence ID" value="ADW69297"/>
        <property type="gene ID" value="AciX9_2259"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2259"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_2_0"/>
    <dbReference type="OMA" id="REILICF"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="13419" checksum="245F6091BE9EBB04" modified="2011-04-05" version="1">MQDFRQLAVWKRAHLLVLHIYEASEAMPEAERFGLLLNLRRTAISVASKIAEGSGRGSDAKFAIELRRSRAAITELEYLLLLSRDLGHLPETQFQSLTEEIVEVRKMISGLISRLTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A1</accession>
    <name>E8X3A1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3396</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581714.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3396"/>
    <dbReference type="EnsemblBacteria" id="ADW70402">
        <property type="protein sequence ID" value="ADW70402"/>
        <property type="gene ID" value="AciX9_3396"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3396"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032465_0_0_0"/>
    <dbReference type="OMA" id="YTVAWID"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="51214" checksum="4E82A2D8A28A2948" modified="2011-04-05" version="1">MPQSASSSTSDSTEAAGGARSAEQKGGAEFESWGRYPKYPGNIVPLQWQQDFPAKLDGLHNGALPVGMGRSYGDSCLLNGGNLLLTTSMNRLLSFDPETGLLTAEAGITLAQILDFAVPRGFFLPVTPGTKYVTLGGAIANDIHGKNHHVAGTFGSHVTQFELVRSDGSHRRCSQTENPDWFAATIGGLGLTGLIPWAQVRLRPIVSRMIDYEGIQFHGIDEFLDLTQQSQSVEYTVSWIDCASTGKNFARGVFMQGDHSRIPGELKPSPEPKLVFPFDAPGFALNHATVSLFNTAFFHKQMKPRVQALQDYEPFFYPLDKVLHWNRLYGKSGLLQFQYAIPWESAREGTIAILREVAESGLASFLAVLKAFGDVPSPGLMSFPQPGITLALDFPIKADVTFPLFERLADMTRDFGGRLYPAKDAAMTASQFQTFYPQWEQLARFRDPMLTSSFWERVTGDRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A2</accession>
    <name>E8X3A2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ordered locus">AciX9_3397</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581715.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3397"/>
    <dbReference type="EnsemblBacteria" id="ADW70403">
        <property type="protein sequence ID" value="ADW70403"/>
        <property type="gene ID" value="AciX9_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3397"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_0"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14884" checksum="E8A8C83696236491" modified="2011-04-05" version="1">MPRVKRSTKRADRRRKILKRASGYFLTKSKLYQAAQEAVERGLKFAYTGRKQKKRQYRSLWIVRIGAGALKNGMSYSTFINGLKLAGNTLDRKILADIAANDAAGFTALVEVAKSARANAAQGHADRQKAEAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B3</accession>
    <name>E8X3B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3408"/>
    <dbReference type="EnsemblBacteria" id="ADW70414">
        <property type="protein sequence ID" value="ADW70414"/>
        <property type="gene ID" value="AciX9_3408"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3408"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047420_0_0_0"/>
    <dbReference type="OMA" id="NNDMIGN"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230196" evidence="1">
        <location>
            <begin position="30"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="509" mass="54206" checksum="AD965F6203580622" modified="2011-04-05" version="1">MLETGKKKLKRVRLTKMLCSAVFAVTASAGLAQVKAPVHIPESGDALPIAAADPEIAGALAKISPDDVRNDIAKLVSFSNRSTVSSTVKDLPAGTGVTAAADWIFAEFTRISAACGNCLEVKRDDFIEPAATGPNGRIKQDTRIQNIYAVLPGTDPAQKARRVLVTGHYDSRVTDVMDTHTPAPGANDDASGVAVSIESARVLSKLKFPATIVFVAVAGEEQGLNGSRHLAKLAKAEGWSLEAALNNDIVGGDTTPGDTGQDKSAVRVFSEGVPGPATPEEVRAIQNLGAEGDSPSRELARAITEVSDSYFKSSSIGAAKGRPGQPHSHLVRYVPPFHPVLIFRRDRFLRGGDHTSFNAEGFAAVRFTEWQENFNHQHQTPRTENGVLYEDNIQFVDMSYVANVARLNAATLATFARAPGEPENVHILTRGLDNNTELTWTAPAGAPAGTIYQVLWRPSDAPVWTNLQSAGSAMTIKLPISKDNVVFGVRTSDAAGHTSPAVLPKPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B5</accession>
    <name>E8X3B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581728.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3410"/>
    <dbReference type="EnsemblBacteria" id="ADW70416">
        <property type="protein sequence ID" value="ADW70416"/>
        <property type="gene ID" value="AciX9_3410"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3410"/>
    <dbReference type="eggNOG" id="ENOG5033D5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1978401_0_0_0"/>
    <dbReference type="OMA" id="MARTNFT"/>
    <dbReference type="OrthoDB" id="1992827at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233619" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13537" checksum="3F2D3EB9E5C29CCA" modified="2011-04-05" version="1">MARTNFTQRVTGSLVLSFALFTSASTVGSVAVLSAQARGPVQRVVQGTVQDKNGVAIKGAVVYLQDSRTNSVKSAIALDNGSYRFVQLTQGTDYSIWAKSEDKKSATKTISSFDTKNELTINLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B7</accession>
    <name>E8X3B7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3412</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581730.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3412"/>
    <dbReference type="EnsemblBacteria" id="ADW70418">
        <property type="protein sequence ID" value="ADW70418"/>
        <property type="gene ID" value="AciX9_3412"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3412"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_1_0"/>
    <dbReference type="OMA" id="ISYAHPH"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008354">
        <property type="entry name" value="Glc-Fru_OxRdtase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01775">
        <property type="entry name" value="GLFROXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="76"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="211"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46644" checksum="772A59817C78BF16" modified="2011-04-05" version="1">MNSAALQPEAPLNRRDFLRSASALAASAGFAGTAIAQQPEKPNAQDKVELSQIHATTEQPEKIPGPFESRDHRTGFAIVGLGRLALGEILPAMGKSKYCKPTALVSGDRQKALKIAAQYGIKESSVYDYTTYDQLARNPDVQVIYIVLPNSMHADFTVRGARAGKHILCEKPMATTAKDCERMIAACEQAKVKLMIAYRSQYEPNDLALIKMIRAGKLGKLRQYIATNSQNQGDPTQWRQKKALAGGGCMPDVGVYCLNAARFLSDEEPYEVQATIVQPKDDPRFAEVEASCQVIAKFPSGFVATFNSSYNAHKSQFLRIEGVEAFAELNSAFAYHGIKLRYSKLIDGQEIMHEPSIEEKDQFAEEMDHMALCVQKNLKPHTPGEEGLQDQRITDAIYESARTGKAVKLSPPHAPTRSPDPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X7</accession>
    <name>E8X3X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3480</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581796.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3480"/>
    <dbReference type="EnsemblBacteria" id="ADW70485">
        <property type="protein sequence ID" value="ADW70485"/>
        <property type="gene ID" value="AciX9_3480"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3480"/>
    <dbReference type="eggNOG" id="COG2427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147298_0_0_0"/>
    <dbReference type="OMA" id="APREHAQ"/>
    <dbReference type="OrthoDB" id="1962779at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="16562" checksum="7AC9268B252BDE71" modified="2011-04-05" version="1">MANPLKFKVVVDPKLELQRQLEAAPVENAEALLVAYDILKTAHANGTLDLVNGLVGGRDIIAAKVAEYAKLPGGIAAIRNLLELSKILMAIDPETLDQLTRCVTAAVGQHQAETKPPSLWALARRATSEDSRRGLSFMTLVLAAVGKSLKGTPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8X432</accession>
    <name>E8X432_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaA</name>
        <name evidence="14" type="ordered locus">AciX9_0001</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578421.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0001"/>
    <dbReference type="EnsemblBacteria" id="ADW67092">
        <property type="protein sequence ID" value="ADW67092"/>
        <property type="gene ID" value="AciX9_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0001"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_0"/>
    <dbReference type="OMA" id="FPAFKIV"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="190"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="401"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW67092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="492" mass="55002" checksum="34386AEA0D44CFD7" modified="2011-04-05" version="1">MSFVPTATAVLNHWVRILGALEKKINRQSFETWLKPTRYSRTVGKTLFVRIPSAQFEHIGDKYGDLIEEAIEKLGFEIESVTFETPQQDPTAPRVREDGGFGPMPSHATNTPGGTNGNGAGNGATSGAIRQNGARGNAAPAAPSTEQARFDWNAASQLNPRYQFDAFVIGSGNQFAAAAAQAVAERPSKAYNPLFLYGGVGMGKTHLMHAIGHEVKRRMPHTSISYVSGEKFTNEMINSVRYDKMTTFRDKFRNVDVLLIDDIQFLAGKERTQEEFFHTFNALHETMKQIVIASDRPPKELADFEDRLRSRFEWGLIADIQPPDLETKVAILQRKAEAESTTLPTDVALFIASNVRTNVRELEGALIRVIAWCSHHGVECSLPVAQQCLKQFIDTQVRKITIEAIQRAVAEQFGMRVPELKQKNNSRQIVVPRQIAMYLAKQMTEASLPEIGRQFGGKHHTTVMHSIAKIDEQRRADKDLNRTINKLMETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X441</accession>
    <name>E8X441_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_0010</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0010"/>
    <dbReference type="EnsemblBacteria" id="ADW67101">
        <property type="protein sequence ID" value="ADW67101"/>
        <property type="gene ID" value="AciX9_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0010"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335957_0_0_0"/>
    <dbReference type="OMA" id="WIFEPAT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="21439" checksum="17560EA8B0C75611" modified="2011-04-05" version="1">MFDDEKKLGSDKSLRTAAVSAVVHVLVIAGLVGVIHSSRVIAPYRLPGTAKGTQLLTYFSPDGSASKAATPVVAKPKAVRKAVAEAKVTMPPQETAEAKVTVGSSSTNGASGQGSGDISIALPQKFPWPRPALDSMGHGTKGDVVLDATIDEQGKIASLVVTQSVNATVDEAVLATVRAWVFTPAMKQGKPVASEQEFRFHYERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L2</accession>
    <name>E8X4L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2385</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580738.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2385"/>
    <dbReference type="EnsemblBacteria" id="ADW69422">
        <property type="protein sequence ID" value="ADW69422"/>
        <property type="gene ID" value="AciX9_2385"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2385"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092293_0_0_0"/>
    <dbReference type="OMA" id="CSTKNYV"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="127"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="27157" checksum="AE7FF9DCC447F9C9" modified="2011-04-05" version="1">MNASSSRLSQSLNSRFSTSKVVSLLALSGSLVLSLATIGCSTKNYVRSQTAPLVQNTNELDAKTASDHRALVDTDERATKGIAGAQAAADQAGQHATAAGQSADQANQAAQGASNRVDSLNGVIANLDNYKQLSDVSVTFGFDKTVLTKSDKEQLDGLAASLQSARGYLLEVTGGTDSVGDAQYNYKLSQRRADAVVDYLSAKYNVPPHKFYLVGIGKDAQIASDKTASGRAQNRRVEVKLMSNMTSGGATAASNAISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G6</accession>
    <name>E8X5G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580829.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2480"/>
    <dbReference type="EnsemblBacteria" id="ADW69513">
        <property type="protein sequence ID" value="ADW69513"/>
        <property type="gene ID" value="AciX9_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2480"/>
    <dbReference type="eggNOG" id="COG3847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171854_8_0_0"/>
    <dbReference type="OrthoDB" id="2065691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6462" checksum="DD40C88E098AE2DE" modified="2011-04-05" version="1">MKGYKQFLNELLRDETGQDLIEYALVAGLIGLGAVVSFGGFENKVRGAFNSIGNQLTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G7</accession>
    <name>E8X5G7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2481</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580830.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2481"/>
    <dbReference type="EnsemblBacteria" id="ADW69514">
        <property type="protein sequence ID" value="ADW69514"/>
        <property type="gene ID" value="AciX9_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2481"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_0"/>
    <dbReference type="OMA" id="PWIRVRE"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20969" checksum="3F27E1A1810850A3" modified="2011-04-05" version="1">MSIKTVSSREVYRNAWTRVREDVIERANGVRGIYGVVDKDPACIVIPLERTAEGEFVTLVEQYRYTVLRRAFEFPQGGWETADVVAEELARGELREETGLIAERMTELAALQIAYGVLNQRQHVFLAEGLTQGEAELEPEEHDLTVHRVSVREFEEMLLDGRVVDNCTASAWGVYLVWRGRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L6</accession>
    <name>E8X5L6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581954.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3640"/>
    <dbReference type="EnsemblBacteria" id="ADW70643">
        <property type="protein sequence ID" value="ADW70643"/>
        <property type="gene ID" value="AciX9_3640"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3640"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_1_1_0"/>
    <dbReference type="OMA" id="RYSIRIN"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10835" checksum="1406BD72DFB03FDD" modified="2011-04-05" version="1">MIQSFGCKDTFSLFITRKTRRWTAIQSVALRKLDQLEAAIHLEDLKAPAGNRLEMLKGNRKAQHSIRINDQWRICFVWWANGPHGVEIVDYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P5</accession>
    <name>E8X5P5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3671</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3671"/>
    <dbReference type="EnsemblBacteria" id="ADW70672">
        <property type="protein sequence ID" value="ADW70672"/>
        <property type="gene ID" value="AciX9_3671"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3671"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625133_0_0_0"/>
    <dbReference type="OMA" id="DNGSMRI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="48736" checksum="A0756DCF00C5A104" modified="2011-04-05" version="1">MKILGQLLLVGVVVFVLLQAVRPSIPAPAATAELQAPPQVMQVLRKDCYSCHSNERRLAWFDEIVPGYWLVRHDILTAREHVNFSTIGAKPAAMQKATLFEAVNMIQLGAMPLPQFTALHPDAKVTPEELSILKAYLAPWSPVAPAAPKTDAAVTAPAAALVSLTSVLPEFDGFTFDGSFEGWKPLSTTDRGDNNTFRFILGNEIAVKAAQSGNISPWPDGAQFAKVAWQQEPGADGLVHPGKFVQVELMRKDAQRYKNQEGWGWGRWRGMDLKPYGKDAKFVNECTSCHQPVKGDDYVYTMPITPAKVAKVEVVNNHAAALPASLPYQPLGWNAITMYVDPKTHTMATLYGNDAAVKATGARGAIAAGAVSYPAGAVLALVTWVQRDDPHWFGARIADSPQAVEFVEVGATHAYRRYAGDGLPEDRREAGLAMQRTAFVTGLAPARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R1</accession>
    <name>E8X5R1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion protein, VC_A0110 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3999</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572707.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70795">
        <property type="protein sequence ID" value="ADW70795"/>
        <property type="gene ID" value="AciX9_3999"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3999"/>
    <dbReference type="HOGENOM" id="CLU_028593_2_0_0"/>
    <dbReference type="OMA" id="VPSMTIM"/>
    <dbReference type="OrthoDB" id="140284at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="615" mass="69264" checksum="11E3CD808F0D08B0" modified="2011-04-05" version="1">MSEELLEYYERELNYLRQMGGDFARRYPRVASRLLLTGDSCEDPHVERLLEGFAFMAARVHRRIDDDFPEISESLLNMIYPAYLRPIPSMTIVECLSDPGQGKKTAGTKIPRGSAMVTKATVDGMPCRFESAYEVELWPFSVVEAEWRQVERLQYPVRASGEVQAVTAARLKLKCFQDVEFEGLPLSTLRFHLAGDASVVYNLYEMISANCIEIILRDPKNRTRTISLEPGQIRMVGFEKDEAVIPHERRSAEGHRLLQEYFALPEKFLFFDLSGLEALGETGFGDEAEIIFLFSRFERSDRQQVMELGVSARTFRLGCTPVINLFPQTAEPILLTQTKHEYTVIPDGRHAAMMEVFSIDEVIAANPKLRQSVTLEPVNAHRYETREQKDTAYWTATRNVSQLGEREPSVLTISVVDLNGQLKSPDADVLTVRTTCSNFDLPSRFNFGTTESDMEAVGHAAAKVVNVLRRPTASADPPQGKGQVWRLVSLLSLNYLSLTEDGKTALQEILRLHNFTDSQHLENHIGSIQKMTSGPHFALVLSDYGLVPARGTEVHLELDEQQFVGGGVYLFAAVLDRFLAGYASINSFSQLSVRTNLRKEVMRTWPPRAGTKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T1</accession>
    <name>E8X5T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572727.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70815">
        <property type="protein sequence ID" value="ADW70815"/>
        <property type="gene ID" value="AciX9_4019"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4019"/>
    <dbReference type="HOGENOM" id="CLU_090632_0_0_0"/>
    <dbReference type="OMA" id="GHGENVE"/>
    <dbReference type="OrthoDB" id="2061199at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="25998" checksum="A4260C9BC4558598" modified="2011-04-05" version="1">MIRSLLVRGMLTGILAGLIVFAFARLVGEPEVDRAIAFETAQDQSKGEAAETPIVTRPTQKGLGLLTGTIVYSIALGGIFGLVFAYAQGRYAITEPRPLAALIALLGWLSIVLIPTLKYPANPPAVGDPATIGIRTAAYFLLIALSLATLTLPFQLNRRLTPHLGTWNAAISASAIYVLLVAILYKLLPVIDEVPKDFPATLLWRFRIASWGMQAVLFATIGLIFGFLTERDQNTHRQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X610</accession>
    <name>E8X610_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar FlbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4114</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572806.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70894">
        <property type="protein sequence ID" value="ADW70894"/>
        <property type="gene ID" value="AciX9_4114"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4114"/>
    <dbReference type="HOGENOM" id="CLU_173020_2_0_0"/>
    <dbReference type="OMA" id="HQIESIE"/>
    <dbReference type="OrthoDB" id="2007051at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7484" checksum="FD60BC9F6D57DF42" modified="2011-04-05" version="1">MVAVTGLNGVVFAINSDLIEHAEATPDTVITLTTGNKLVIREGLEELIDKVIAFKHAVRMGLGLGVDTTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E1</accession>
    <name>E8X6E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4249</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572937.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71025">
        <property type="protein sequence ID" value="ADW71025"/>
        <property type="gene ID" value="AciX9_4249"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4249"/>
    <dbReference type="HOGENOM" id="CLU_030705_1_0_0"/>
    <dbReference type="OMA" id="GWCQGRM"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017224">
        <property type="entry name" value="Opine_Oxase_asu/HCN_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037495">
        <property type="entry name" value="Opine_OX_OoxA/HcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="45345" checksum="8989FB346B36529F" modified="2011-04-05" version="1">MIWTDVLVIGAGPAGIAAATAAGENGREVIVLDDNAAPGGQIWRGGVEAPVAKPGGGEDAAKDKAIARLKRSGAELLSGYRVFDAQSSSTVQAIHQNQTDRFSYKHLVLATGARERFLPFPGWTLPGVFGAGGLQALVKGGFPVKGKRVVVAGTGPLLLAVAAHLKAYGAKVVCVAEQASVSQLAPFAASLWSHPAKVWQGVHYRATLASTPYRNGCWPVAATSNQDASALSSVTLSDGKRTWDEPCDLLACGFHLVPNTELASLLGCELEGAFVKVDEQQRTSLPEVFCAGEPTGIAGLEAALIQGEIAGLTCAGKPTSQLKKRAAAERGFGQRLEKAFALRPEVLKLATPQTIVCRCEDVPLGKISGHIGWTDAKLQTRCGMGPCQGRICGPAVEALLGWRPVSIRQPLYPVPLEVFCSEQEEPEPVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H5</accession>
    <name>E8X6H5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4291</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572969.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71059">
        <property type="protein sequence ID" value="ADW71059"/>
        <property type="gene ID" value="AciX9_4291"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4291"/>
    <dbReference type="HOGENOM" id="CLU_182089_2_0_0"/>
    <dbReference type="OrthoDB" id="2016183at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7934" checksum="8302EEED27107CD7" modified="2011-04-05" version="1">MRTLIDIPEEDIAAIKQVTVALGISRAEFVRRAVSQSLEPYRTSGHSEAFGICAGKLEDGLQFQDRLRGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I0</accession>
    <name>E8X6I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4296</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71064">
        <property type="protein sequence ID" value="ADW71064"/>
        <property type="gene ID" value="AciX9_4296"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4296"/>
    <dbReference type="HOGENOM" id="CLU_029191_0_0_0"/>
    <dbReference type="OMA" id="LWCGTCH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="3">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="600" mass="64681" checksum="D4C3369538F750F7" modified="2011-04-05" version="1">MTRPARILAAAAIIVAITIVCPILTTASSSLGWASSKARPSSSIAEQIKPLTVQASESLPPLTNPDLVCATCHQAIYARYEQTPMAQGSGPADTNLIPGAFRHTPSNIDYRIFLRDSTPYMSFSRDGNPPLSGERKLLYFIGSGRRGRTYLYRSDTQWFELPINSYTRRNTWDMAPAFDAVTSMPAVLPTDPNCLHCHATDVQPSLPTARNRFAAEPFRQGGIGCSACHGDPTAHLAQSGHGPILNPNKLSPAKRDSACIQCHLEGDAVVYKPGRSLAQFRPGEDLAATAVYFIRASHQAGAAPNQAGAAPNQSGAARATSQYEALLRSACKRATGDRLTCTTCHDPHSTPAPAERVQFFRARCLACHTSPKLAATHHPEQPDCALCHMPTRPTTDISHEQLTDHDIESRPTHLQTLAASSDLDKLVTVGGVPATEAEYGMAYAQLAAHGNAAYAREALRLLTHAASLQPDQAPLAPEAEVQLAYLRQRDGHPTQARANYINVLRQLPYEPTALANLGVLDASTSNLAESLRLLNRLIDADPSHTAAGLNLAFIDCSIGRKQDAQAILKRLADINPDDPQLRIFQTQGTYAGQHCALTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I1</accession>
    <name>E8X6I1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4297</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71065">
        <property type="protein sequence ID" value="ADW71065"/>
        <property type="gene ID" value="AciX9_4297"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4297"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_0"/>
    <dbReference type="OMA" id="HNLKMKV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="439"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="580"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="862" mass="96233" checksum="01B6CA7ED6517015" modified="2011-04-05" version="1">MTLRQTEHHHHHSRNYIRIFNLIILLQLVLGAVAWRESVAIRRLALVITAQRAALVSAHERIEHLQQDLSSATSNLPDTLRPDFTARQELAEHLSASLLRLAELDSILNAREIAAAKAQAATFHTLAVSPIDPASFNQAVRQTSATSSLWQAAALRADSDIQHQLITARRAFVWMQCALALAPFFILAAVGCIILLKRDVRLEARQRQRVEDELRLERGTLEARIVARTVELQSEVLERQRAEQLNRGRNHLLEMLAREEPATHIFSALVDIITRDRSRWCCALYIIRGAELHLEASSNLPASLLRNLHQLPTSIHEVPALQAHKPYILEDLTRARTPWTQLLYANGIQSLWSAPIFAPDGAPLGILTIYSLLRCTPSQLDLDLLESHAQMTAMVLERYRLQQELRRHAYHDNLTGLPNRLLGEERLASAIRRGRRAGSPVAILWIDLDKFKQTNDVHGHVAGDNILKEIAARLSRRFRDSDTIARMGGDEFMAVLEDITDRSAARKIAEQLIAELALPIPFGDLMLVTEASIGISLFPEDGDSADLLQRNADMAMYEAKFGHHGVRAFSPALDSILTERRDLEKAMIHALDHGGFALHYQPQYANDGRLSAFEALLRFPHPVMGMVSPARLIPIAEESQMIVALGTWVLREACNQSMRWQKAGLPEVLIAVNISAMQFARQDFAHHVAEILEETGLHPELLELELTESVMVKDFAESTRQLERLKRLGVSIAVDDFGTGYSSLNHLHRLPIDKLKIDRSFIQALSEPNGTLPIVESIIAMAHRMGMCVVAEGVETPRQMATLREKSCNILQGYLFSPPVEADRAALFLATGTNPRLTSAELTIPALPSHPATLTIPAPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I7</accession>
    <name>E8X6I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4303</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572981.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71071">
        <property type="protein sequence ID" value="ADW71071"/>
        <property type="gene ID" value="AciX9_4303"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4303"/>
    <dbReference type="HOGENOM" id="CLU_080120_0_0_0"/>
    <dbReference type="OrthoDB" id="1695614at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26296" checksum="74206199F9541CED" modified="2011-04-05" version="1">MQPSLLSLADQSLYNIVSTATPATIADVIATMQAIDALLPPEDGLKWFNRLYLMVTQQVDFNPPAGGWKNPRWLTQLDVVFAGLYFKAVADFLAGRPIPASWSAMFASRHTPGIDRIQFALAGMNAHINHDLALALIATDTALNVTPTLTSPEFTDYQAVNQLLNALMPATLTMLATDTLGVLAQDTGKVGRLLAFWDMCRARELAWLFADHLSSLAGPPRALALNAQDSMTGVLARAILAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L2</accession>
    <name>E8X6L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3881</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582181.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71162">
        <property type="protein sequence ID" value="ADW71162"/>
        <property type="gene ID" value="AciX9_3881"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3881"/>
    <dbReference type="HOGENOM" id="CLU_056689_1_0_0"/>
    <dbReference type="OrthoDB" id="1564715at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="29362" checksum="0672D04A26CD0E0E" modified="2011-04-05" version="1">MSVILTDPTPDTLSTQSAKLVENRSSVLTSRRCVLSTLAVAGAATAFSGSLAGCSSDGSVPLASSTPSVLDVLNFALNLEYLEASFYLYVTTGTGLSTADMGTGAGSVTGGAKVSFVNPIVAAVANQLATHERQHVEFLRSTITAVGGTPVPMPSINLAAGGAVTSDATFLAASRQLEAVGVSAYIGGAQYLTSSTAALTYAAQILDTESQHAGFIRELCIALGVTSPAVDSLDQPPTATQIFNTSNTTGLTPVRTTSQVLQIVYAAAGQTGVSKGGFFPNGLNGTLITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L5</accession>
    <name>E8X6L5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3885</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582184.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71165">
        <property type="protein sequence ID" value="ADW71165"/>
        <property type="gene ID" value="AciX9_3885"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3885"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="VGNRQWR"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234451" evidence="1">
        <location>
            <begin position="17"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1132" mass="120849" checksum="DC0F7AD9FAE5F34C" modified="2011-04-05" version="1">MNRHISGFLCSVSAVAAMGAGIGAAQTVTGTVTGMVTDPSGAVIPNAMVVAHNVDTGVDSNAKTDSAGLYRIAFLPIGHYTVAISGSGFGTQNVPQFTLEALQTTTFNVKLALGSSETTVNVSEASEILDTNDATLSGTFTANTIQNFPLNGLDFSALTLYLPGSVSTSGTGGTTSIERSLNNSDTVNLNGNRAQANNFTLDGIDDNETFNNLIAYSPAPESLQEIKVLTANSPADYGNVNGGGIVSILKSGTNTFHGSAYGYVQDYRTNANSYNNKHVTPVISTNPYSQAQFGGTFGGPIKRDKLFFFVDYLGSRYHRGGTGTASVFTQAMRNGDFSALLNTAGATPIQLYDSVNNYAPFVGNRGVAVINPVAKYLFAHPELYPLPNATPDPDTVLNNNFQGPIRTYRANNQGDIKIEYDPRSADKITGFYAMSTAYDGSTALLPVTFPSVSIFPTRLFGATWVHIFSPSIVNSARAGFTRTDWNQGLPLDPSGVFGTRGNSIVGIPFPNQAYNGFSAQNIGGLSGVGTGAFDGGLIDNTFSYVDNITWQRGTHTITAGIQALRYQNNYPTSNNNGYLGNIGYGGAFTSNPNLSNAPGYGGADFLLDRVSSAAVTLGSVNVGQRQWRTAGFVSDDFKAMPNLTINFGIRYEYDQPWIESNNKTGNVDIATGQVLYAGRVPVGAPAGSGVCSTRACYDGNHTQIMPRLGFSYQANSRFVIRGGYGATSFYEGNSSNQRLTSITPFIQAVNVTVVTPTVGNPGAPRTAEQGFTGGTTAYGGTFNVYPKNIQPAYVQEYNLTAEYAMTRSLSLQVGYLGEGGQHIEDYGNLNQYKVNGDETSAPYYNNKYIGINAVDPSISIGSNSLLITESRATMNYNALQAVLRQRTTHGLEFTLNYTYGKALTNSLGNYGLNVNGFSGAFQNYYDSGADWGPAGYDVRHNFSGNGVYALPIGRGRDYLSHVNRFVDEAIGGWKLAVAAVAYTGFPETLTGPGNNSNSYGSSRPNQYRALKIVNRTLENYFGTDPSAIPCTTPGVDNGVCAFGTPANNSFGTARNGNVRGPGYLNVDMSAFKDFHTFREQTIGFRFDAFNAFNITSYGNPDSGITDSTFGNVSNQGVRSVERHLQFSGSYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T8</accession>
    <name>E8X6T8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ig family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3962</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582256.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71238">
        <property type="protein sequence ID" value="ADW71238"/>
        <property type="gene ID" value="AciX9_3962"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3962"/>
    <dbReference type="HOGENOM" id="CLU_295741_0_0_0"/>
    <dbReference type="OrthoDB" id="331848at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1022" mass="102737" checksum="26102E8290F58975" modified="2011-04-05" version="1">MLKQFSARITAALLVCFLGGLIGLNGCGNGTTSGSGGSGSTGSVKIATASLAAGTVGVAYNATIVASGGSQSYTFSVITGAPPTGLTVNAAGLVYGTPTLGGTFNFTVTVTDGSGSKASLYYTLVINGAVATTPVSISTVTLPNGTVGTAYSATVTAVNGKTPYTFASSGSVPAGLSLSTGGVLAGTPTTAGSYSFTVGVTDAIGGKASATYNVTIAGVTSPTSLQISTTSLPSAVVGTAYSAMLSAVNGTSPYSFSSGVTLPNGLSLSTAGALTGTPSTQGSYPIPFTVTDAKGQQASATLTLLILQAAQAVTITTASLPSGTANVAYSTTIAAANGTTPYSFTVSGTLPNGLSLSTLGVLSGTPTASGSYSPIITVTDAANGKASTTFNLVIAPAVSGSSLSVSTTVAGALINTSYSSVLAITGGTGPYKVTQAGGTLPNGITLASNGTLSGTPTATGSYSFSVSATDSSTPLQTATATISLSVATATVTVNTATTLATVPANFFGLHTSVYDGSLGDASGVAPVLKAAGITTLRYPGGSYADRYHWAQYSETPLYTSTAPACGIVQGELQLEPTSDFGHFIKTVQASGATPLITVNYGTSLGDANGTKKAGTMGLTNNCSEPNQPGQPQEAAAWVAYANGDPANTQVIGIDAVGFNWKTVGFWAGLRAANPLANDDGYNFLRIGNTAPIGIKHWELGNEMYYNGWAGNRNFEGDLHAPYIYPNGYSPGAYESRDQLAALSPAAYGANSAAFIAAMKAVDSTIQIGLDFSSPIYDDPIPGNWNTDVPQAACGLGNFDLAIIHYYPGTYLAVQPGELLSLPQVEIPNVVAGIKKSLAQYCPSNAANMRFVLSETSPNATLAPGFPNEVLGLFVINEYLTALQQGILNVDYLELHDMAGTFLSFDEKTPGPVFYGLQMAHQLAGTGDSVVSAVSSSSTVVSYAAAKSNGQKALILINADASNAAVVQVSFPGATLGATATQYSYGVGTKPSGTALTGTSFAVPGSTFNVTIPAYQAVELILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z0</accession>
    <name>E8X6Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3813</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582121.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71099">
        <property type="protein sequence ID" value="ADW71099"/>
        <property type="gene ID" value="AciX9_3813"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3813"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_0"/>
    <dbReference type="OMA" id="HQGNANF"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="23018" checksum="4DD5DEFD5DE0E711" modified="2011-04-05" version="1">MKQIRVLLIEDHFLARMALHSVLSGHAQIAVIGEASDGELGIAMYREHRPDVVVLDLRLPRVSGFDVIIALRKDFPTAKIVILSNYQGSEDIYRAVRSGAMAYLTKDASGEELLNAIQSVHRGLRYLPHVALDRLAERTPAVDLTPRESEVLVCITQGRSNQEIADELGIAEKTVRIHVSSLLDKMGARDRTQATIYALQRGLVHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X720</accession>
    <name>E8X720_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582151.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71129">
        <property type="protein sequence ID" value="ADW71129"/>
        <property type="gene ID" value="AciX9_3843"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3843"/>
    <dbReference type="HOGENOM" id="CLU_044590_3_0_0"/>
    <dbReference type="OMA" id="DWPVCLV"/>
    <dbReference type="OrthoDB" id="1979322at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="33289" checksum="0FF0F4C99BCB6AC1" modified="2011-04-05" version="1">MSLQENAGERIDAHHHLWRYDEAEFGWIDDTMNLLRRDFLAPDLTPLLQVSGVTGTIAVQARQTIEETHWLLTTARQFPWIRGVVGWLPISDVRFEDHLDLLTAEPMLKGLRHIVQAEPPGFLDDPGFNRGIRQLTRCGLTYDLLIFSKQLEEALRFVRRHPQQSFVIDHIAKPNMEAVGFAFWSRLIREFADLSNVTCKISGMVTETRGTPWNPEFLKPYFDVVLETFGPSRLMTGTDWPVLTMRCGYRQWWQTVEEWIAPLSAFERSNILGETALRVYHTIPAQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X768</accession>
    <name>E8X768_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4350</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71302">
        <property type="protein sequence ID" value="ADW71302"/>
        <property type="gene ID" value="AciX9_4350"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4350"/>
    <dbReference type="HOGENOM" id="CLU_2879573_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="6976" checksum="0970370A95173842" modified="2011-04-05" version="1">MAAEHKHIAILSAETAGHGIIIHFSDGTTTLFQTHFLYEVREEDGNVALTDLSEDDLMKGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X787</accession>
    <name>E8X787_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4369</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71321">
        <property type="protein sequence ID" value="ADW71321"/>
        <property type="gene ID" value="AciX9_4369"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4369"/>
    <dbReference type="HOGENOM" id="CLU_3168641_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5338" checksum="F0CB460D06D3E26C" modified="2011-04-05" version="1">MSAMPPLLLKLWREQHPKGHEQTNLNFKVQGPPAALVPLFKSEISEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E4</accession>
    <name>E8X7E4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ArdcN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573097.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71378">
        <property type="protein sequence ID" value="ADW71378"/>
        <property type="gene ID" value="AciX9_4431"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4431"/>
    <dbReference type="HOGENOM" id="CLU_012069_0_2_0"/>
    <dbReference type="OMA" id="RKVMKGQ"/>
    <dbReference type="OrthoDB" id="1509644at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArdcN" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="301" mass="32605" checksum="7C9EBDC36ECB263C" modified="2011-04-05" version="1">MSNIATMPTNPKPQTSKEVIAANVQLLIEQLEAGHSEGLTAYLSAMGKFHNYSFGNILEIARQKPDATRVAGLYAWNQLGRKVMKGQKGIRILAPMIGGRKKKDTEANSSKDAAAIDKPVLVGFRAVYVFDVSQTEGAELPDLNERVKGEVGDYRERLVDFIIAQGIQLEFKESIAPALGMSYGGKIAILPGQAPAEEFNTLVHEVAHELEHKAERRTATTKTVRETEAEAIAFVVSQTIGLNAGNAAADYIHLYDGNATLLTESLEVIQRISSFILSAIQPLAVKAEEETTDTVAIAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G0</accession>
    <name>E8X7G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4448</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573113.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71394">
        <property type="protein sequence ID" value="ADW71394"/>
        <property type="gene ID" value="AciX9_4448"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4448"/>
    <dbReference type="HOGENOM" id="CLU_189062_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230316" evidence="2">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9525" checksum="5B8FCE5D674A5A21" modified="2011-04-05" version="1">MLKAVNTKILVAILAVLSAIGATLIHIHDTNQAAAASAAKAAAILQLQKDDADAAKKHDEELWKGIREQRKKNNVNPTGGSKPWTTYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M2</accession>
    <name>E8X7M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4515</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4515"/>
    <dbReference type="EnsemblBacteria" id="ADW71456">
        <property type="protein sequence ID" value="ADW71456"/>
        <property type="gene ID" value="AciX9_4515"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4515"/>
    <dbReference type="HOGENOM" id="CLU_2093397_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="116" mass="13098" checksum="C7C59EC83841B2FD" modified="2011-04-05" version="1">MGGERASKTRQREAGKICCICSLTLDAPPWGTYGERRCGKCAAKQPKRRVLMNFMLRQGWHISFLEEDCQTSLRKKHTFADDSKVLEMEVKGDARFDSEGRMMFERGISQGAAGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R0</accession>
    <name>E8X7R0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4563</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4563"/>
    <dbReference type="EnsemblBacteria" id="ADW71494">
        <property type="protein sequence ID" value="ADW71494"/>
        <property type="gene ID" value="AciX9_4563"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4563"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_0"/>
    <dbReference type="OMA" id="FFTEDTP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="379" mass="42354" checksum="911C21A1288B4880" modified="2011-04-05" version="1">MKETDITSPFVKPSNQDQPVLITGGAGFIGANFVLDWFKQPNARPLINLDKLTYAGNFASLAPVQDNPAYHFVHGDILDGELVARLLREHHPSAILHFAAESHVDRSISGPEAFLKTNIDGTFVLLREAHTYFQTLTPEEQVTFRFLHVSTDEVYGTLTPDAPAFHEDTPYAPNSPYAASKAASDHLVRAWHHTYKLPTLVTNCSNNYGPLQFPEKLIPLMITQALTGKPLPVYGDGQQVRDWLYVGDHCSAIRAVLAGGRIGETYNVGGGNQRANLQVVNTLCDLLDELVPHSPYAPHKQLIRFVTDRPGHDRRYAIDARKIESELNWHATESFETGLRKTVAWYLANTAWTENVTSGAYKNWIQQNYSHRTESGEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W8</accession>
    <name>E8X7W8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4622</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573271.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71552">
        <property type="protein sequence ID" value="ADW71552"/>
        <property type="gene ID" value="AciX9_4622"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4622"/>
    <dbReference type="HOGENOM" id="CLU_2193259_0_0_0"/>
    <dbReference type="OrthoDB" id="2207530at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="12541" checksum="17421B2A8A58A9B4" modified="2011-04-05" version="1">MTDAQQLKEIANQKFEDPYLLGRIVSRLRENDTFVQKHRDRRKCDLFWRNAGAYWRCTIFVSLESEDILAQVDLHVDGITRVESYEPCSITIDPTENLLVLSRIAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z5</accession>
    <name>E8X7Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71579">
        <property type="protein sequence ID" value="ADW71579"/>
        <property type="gene ID" value="AciX9_4649"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4649"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_0"/>
    <dbReference type="OMA" id="YRWMVRS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="33713" checksum="C5ABFA71DF8FD271" modified="2011-04-05" version="1">MRYELKTEMVAANDLVFEVLTCGTGKTLALCLHGFPEVALSWREQMLALAESGYRVWAPNQRGYGKSSRPPRMQDYAIENLMADVAALIDASGAQHVVLLGHDWGGIVAWCFASRRLRLLDKLVIINVPHPVCFARSLRRPEQFVRSWYAAAFQMPFLPEWFLRRKNAKGIEEAMLRSSTRPESFSRDLLEATRSNAAEPDALKAMVDWYRAFVCGGGLQRQLRYGFPRIEVPTLLIWGEEDRFLTKASTIGTEEFVTLLSMHFLPGVSHWVQQDATEQCNRLILQFISLELATSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X825</accession>
    <name>E8X825_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573327.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71609">
        <property type="protein sequence ID" value="ADW71609"/>
        <property type="gene ID" value="AciX9_4680"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4680"/>
    <dbReference type="HOGENOM" id="CLU_2508077_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="10228" checksum="03E7FF9F3DBA0F0E" modified="2011-04-05" version="1">MAKTKKETDEHRHRTMLINNSLGEEYTAWYGWPEHSPYGRYLALGEYIVELCEEPRHDEWFDAAKEAYLKWKKERGYDNTPPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X839</accession>
    <name>E8X839_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4696</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71623">
        <property type="protein sequence ID" value="ADW71623"/>
        <property type="gene ID" value="AciX9_4696"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4696"/>
    <dbReference type="HOGENOM" id="CLU_2259817_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11561" checksum="0F10C776A959710D" modified="2011-04-05" version="1">MGSRLTGLFAEAQGEYVLNFVVEGSSSYALFPADFSLLTADCALLSPNPAFFSTDAMHLLRGRRELHLFVQVVLSLNERRLLGPENSLLLTQRFQHTVKLCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV95</accession>
    <name>E8WV95_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0196</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578598.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0196"/>
    <dbReference type="EnsemblBacteria" id="ADW67270">
        <property type="protein sequence ID" value="ADW67270"/>
        <property type="gene ID" value="AciX9_0196"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0196"/>
    <dbReference type="eggNOG" id="COG2116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061519_1_0_0"/>
    <dbReference type="OMA" id="GWMIATM"/>
    <dbReference type="OrthoDB" id="1834167at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="31105" checksum="C58F4A10CD508EE0" modified="2011-04-05" version="1">MASRLRRRGAGKDEQPASAGQKHLSRPSAQDIYNQVAKNARQELKRSSVSLGISGFAGGTFMGLTALGTAIALSMLGHSPGAVMISRMFYPVGFIVVILGRSQLFTENTLYPVALILSEKKEFWNTLRLWGVVLPANVLGAFAFASLVSLTPALNPRFIEALTQLGLDAMANPAQTVFWSGVMGGWIIALTAWLVSGSHSITGSVMIIWTLTFLVGLGNFAHCIATSGEVFIAILTHHAPWMAYPHWFFPAVAGNICGGVGMVTLLEYGQVIYGGDGDGDDSDDAMRVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA1</accession>
    <name>E8WVA1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0202</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0202"/>
    <dbReference type="EnsemblBacteria" id="ADW67276">
        <property type="protein sequence ID" value="ADW67276"/>
        <property type="gene ID" value="AciX9_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0202"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_0"/>
    <dbReference type="OMA" id="RDWYWWR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233895" evidence="9">
        <location>
            <begin position="24"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="10">
        <location>
            <begin position="161"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="708" mass="79765" checksum="1856AAF62874919D" modified="2011-04-05" version="1">MTSLSLKTALLATLLATPFLFSAAQEATASQSGGGNVTAPVVIFQPQPSFSEEARKKKLNGNVLVGLVIDEQGVPQNVRVIRGIGYGLDEKAVEAVHAYRFKPAMKDGKAVSVKMNIDVNFNIYDPKHPPAAQPVSSAPISTSTLINGYEPKWWKEAVVYQIYPRSFQDSNGDGIGDLKGITSRLDYLQKLGVNVIWLSPHFDSPNADNGYDIRDYRKVMTEFGTMGDFDAMLAGIKQRHMRLIIDLVVNHTSDEHKWFVESAKSKDNPYRDYYIWRPGKVGADGKMGPPNNYPSFFSGSAWQFDAKTNEYYLHYFAVKQPDLNWDNPKVRGEVFGLMKFWLDKGVDGFRMDVIPLISKQPGLPDLTAQELSTGGFVALWANGPKRDEYLKEMNRDVLAKYDDMSVGEAIGIDLDQEKQLVDDRRHELNEIFNFDAVRLNRDGRKYVPWTLPQLKAIYTKHAEVLTKHDWDTVFLSNHDNPRVVSSFGDDSAQFRVPSAKLLETMILTLRGTPYLYQGDELGMTNYPFKTMDQFDDIEAHNGYKDEVQTRHVITEEAYIENLRHMGRDNSRTPMQWDGSANGGFTTGPKPWLAVNPNYKTINAAQETGDPDSVYHYTARLIALRADTPALVYGDYKDLDPTHPHIFAYTRTLNGEQYLVVHNFSAEPIAYTLPGGMKAGRSLMDNYGGGESNVTTVHLKGWESRIYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH7</accession>
    <name>E8WVH7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68425">
        <property type="protein sequence ID" value="ADW68425"/>
        <property type="gene ID" value="AciX9_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1365"/>
    <dbReference type="HOGENOM" id="CLU_2843702_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="6720" checksum="790392A1A0688363" modified="2011-04-05" version="1">MPAGVLLARGFIGVCTGFTQALMRVNPGRKKATIRVGIVAVSVTGLEVVGFEGLLDGEAYVVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM1</accession>
    <name>E8WVM1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580865.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69550">
        <property type="protein sequence ID" value="ADW69550"/>
        <property type="gene ID" value="AciX9_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2520"/>
    <dbReference type="HOGENOM" id="CLU_2508074_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="8890" checksum="74937F8C6C1214CA" modified="2011-04-05" version="1">MRSSIGPSKYATKKPPLQTIADPPQDSAAQLAHLATSGRIICFADLALLQLAEARTRRELCAVDAVSTVNAGVIANFALRVTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ6</accession>
    <name>E8WVQ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580900.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69585">
        <property type="protein sequence ID" value="ADW69585"/>
        <property type="gene ID" value="AciX9_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2558"/>
    <dbReference type="eggNOG" id="ENOG5033URI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1515864_0_0_0"/>
    <dbReference type="OrthoDB" id="1885361at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233411" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19655" checksum="B483EA2DD94544A1" modified="2011-04-05" version="1">MRWFTLLLAFSVVSTSYAQVVGHSAPPLDDDPSVILELGAATSWTTTGGAASFAPNLAAETTPIENWLEIEAGVSPFFTRNSTEWDTDFLFKKPWTLSSKAEFMLGVGPEWVYLRQHGTTSNSIAGEVAGDFMFWPNGKHRFGWYLEPAYDYNFMAGHQQSIGMSAGLLIGIRRQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS2</accession>
    <name>E8WVS2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2575</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580916.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2575"/>
    <dbReference type="EnsemblBacteria" id="ADW69601">
        <property type="protein sequence ID" value="ADW69601"/>
        <property type="gene ID" value="AciX9_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2575"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410369_0_0_0"/>
    <dbReference type="OMA" id="FGGQMRG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="650" mass="71226" checksum="B4E3B10F9D043721" modified="2011-04-05" version="1">MPIFLHIVHSLSPFLRGFAALIVALWIAFLVRMIWQAMKVHKANRAILAVLDSVPAASSEERIDGLPLDRINLLRSAFQSSNEHAKDWWNSIEGSLLPLNSPLSEDRWFVSDAARDLFSSEELFEDYADVSHQAVPGILTALGLLGTFSALLLGLADLRYTDKAVLGLSDLINALSGKFFTSVLALGSSLIFVLAERFLFATRFERLYSKVCGRFDRVFPRLTQERVLIDIRKEALSQSVSLSNISSDLVGQLTGAFQQTILPSLSFDLAEQLTKQLLPAIQKMEGALERLESQKQDSVVGEFRSLVTTLETSITNALSDMGSRFHEQLTGSAHSEFAAVQETLSGTSQMLLQMNAQFELTRSALSNLVDAANTSSDHQAKASQDQAEALRQLMHGLIEEMGKNASSNLQNIAGALTNVIADLSRKVEDVSETMIRTVSNAAQGSQSSADALIAKSGAWTEATSQQLTTLLESIEARSGEFKAAGQSLLEAKSLLADVLDRNATALKSMESAARQVEGYTTALTVVARNSDDTQRRQAEVVALSRQIVEELKQTSAGNQGILDQYNRSLNEAKTVFGTLDTQIETLLTKINTGMREYVQTVESNFSVIVKHSNDYLPEISRVLQSQIQELERQLEELTSVFSKALQAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW4</accession>
    <name>E8WVW4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582032.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3722"/>
    <dbReference type="EnsemblBacteria" id="ADW70723">
        <property type="protein sequence ID" value="ADW70723"/>
        <property type="gene ID" value="AciX9_3722"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3722"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="MNARDPF"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230352" evidence="2">
        <location>
            <begin position="21"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="918" mass="97701" checksum="C529219F8B80EFD9" modified="2011-04-05" version="1">MHRFFVAAAWPAFVVPFVSAAAVSPLQAQQPQSACTGRALTGTVQDSTAAVIPGATIQIDGKAGLSKISGSDGRFSFPCVAAGPHHITTNAPGFAAAEQDLPARASADLHITLIPADSVAINVNADEATIDPVPGGLNGTTLTGTQLNTLADDPDDLQRQLQQLAASGGGPPSGTVLSVDGFQDDSPLPPKSSIARIEVNPDLFSAENRQPPFEGGHIEIYTKPGAKNYHGTLFTTNSSSWMNAHNPFSDAPAAIGKQRYGFTLNGPVRKEGSNFSLALEHRSIDEFSVINAVTLDDSGNQVSTVANVPVPQRLWVGSARVDLQLGPKNIAFASFSTKVDHLSNVGVGGSTLLESGYDSQTYDHILRFSDTTTFSPNLLHEGRVSIDFRGEDDVPTSTGPQLEVAGAFTGGGANIGQQRIHQIRTEWDDDFIYTHGKHSLKAGLQLFDYVERQTLSTNFNGTYIFGGGTAPVLNGNTATTATETITGLEQYRRAKLNLPGGTPTQYSSVAGNPQVNLNEFYPVIFVQDDIKLRPNLTLSAGLRYFYANLPFQANGFTPRLGVSWAPGSSKTLTLNAHLGLFAGHSPNGLAFTQAELMREDGVARVTSLVYNPVYGAPATNGSSVIHAVRTLAPNYGTNQNMMAQIGGDKTLPFGFTFSANLIYIRGWHQERTLNVNSPLNGSPTGPRPGALNLNVLQLQSSADTAGDIEFVGVGNQKLKRVQFFVGAVRIHIKSDTDDNAFFSPQSSATNAGEYAIESGNSLWQNFANVTVNLPRNVSLSINYYGNGNSPFNITTGFDNNGDGNFNDRPQFARPGQAGAIATPFGNLVATGGTGVLARNRASLPWSIHADANIQRTFTLTSNSKADHQQTITANIRSSNFLNHTNVTSEGGVLGSPQFLVPFAADNSRRVEGGLRYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW45</accession>
    <name>E8WW45_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0279</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0279"/>
    <dbReference type="EnsemblBacteria" id="ADW67351">
        <property type="protein sequence ID" value="ADW67351"/>
        <property type="gene ID" value="AciX9_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0279"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_0"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="8"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="40934" checksum="E71340EB0910ACD4" modified="2011-04-05" version="1">MIDPESILVTGGAGFIGSNFVLDWFAQPAQATRLINLDKLTYAGNPANLESLRGNPGYTFVQGDINDAALVAKLFAEHQPKAIVHFAAESHVDRSIVGPEAFLKTNIDGTFTLLQAAKNYYATLTPERQEDFRFLHVSTDEVYGTLAPEDPAFHEKTPYAPNSPYAASKAASDHLVRAWFHTYGLPTIITNCSNNYGPYHFPEKLIPLMITHALEGKPLPIYGDGQQIRDWLYVRDHCSALRTVLATGRVGETYNVGGGNQRSNLQVVNRLCEILDELRPDSPHAPHAQLIRYVTDRPGHDRRYAIDARKLESELNWHAQESFETGLRKTVEWYLANSPWVDNVTSGAYQNWMAQNYGSRTEEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW67</accession>
    <name>E8WW67_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4375 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579772.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1391"/>
    <dbReference type="EnsemblBacteria" id="ADW68450">
        <property type="protein sequence ID" value="ADW68450"/>
        <property type="gene ID" value="AciX9_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1391"/>
    <dbReference type="HOGENOM" id="CLU_1737987_0_0_0"/>
    <dbReference type="OMA" id="IVWEDAY"/>
    <dbReference type="OrthoDB" id="1418939at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025402">
        <property type="entry name" value="DUF4375"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14300">
        <property type="entry name" value="DUF4375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4375" evidence="1">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16188" checksum="1FEE46DEA9810A6D" modified="2011-04-05" version="1">MENEQSYTVLMDTVWDDINIYDGPSAFLLSYASAAQPAGILCAAHFVQAEAVNGGFHQLFMNSSGILAPEAVFGFQELGMIKAAEAVEAAIKLLGTGYPLDLAERQQRLAQVPERYLAPLDQQFAEAIDTENGGFEKVANEFVKNLGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL2</accession>
    <name>E8WWL2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface SD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580991.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69676">
        <property type="protein sequence ID" value="ADW69676"/>
        <property type="gene ID" value="AciX9_2651"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2651"/>
    <dbReference type="HOGENOM" id="CLU_1774799_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="146" mass="14410" checksum="3677ADFBA09E98FF" modified="2011-04-05" version="1">MLSALSALRTSELLSNLNTASTSTSGTGSAASTASVSNSSLSTSDLDAPSSSASSPLSKDTVQLLKDLAVGNVSAAKSDIARLQKDLKAQDGSSSSSSSSDNALNKLLTSISKSLDAGSTSDALSTLAGYLIQTGNTSGSIIDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT3</accession>
    <name>E8WWT3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0339</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0339"/>
    <dbReference type="EnsemblBacteria" id="ADW67411">
        <property type="protein sequence ID" value="ADW67411"/>
        <property type="gene ID" value="AciX9_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0339"/>
    <dbReference type="eggNOG" id="ENOG503459J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2219406_0_0_0"/>
    <dbReference type="OMA" id="DHRTSHF"/>
    <dbReference type="OrthoDB" id="2023964at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="11990" checksum="6C29EA867D6E921B" modified="2011-04-05" version="1">MGLTIAAIRTGFDAVGTLPEGAFHTTLDEQLICPKCDASYNLIVDYQASVGRHFGEESRKLIMLLKKAIFMGHSDGHRVVHFETSGVVVRSFGVEVEKKRIVKGSDLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX29</accession>
    <name>E8WX29_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1537</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579909.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1537"/>
    <dbReference type="EnsemblBacteria" id="ADW68590">
        <property type="protein sequence ID" value="ADW68590"/>
        <property type="gene ID" value="AciX9_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1537"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013589_0_0_0"/>
    <dbReference type="OMA" id="RALINDC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1102" mass="119935" checksum="5E997A0868C1A0FB" modified="2011-04-05" version="1">MIPEIGRRFGPYEIQARLGGGGMGHVYRAWDARLQREVALKLLHSEFAMPGMHDRFLREARAASALNHPNICTIFDIGEQDGDPYLVMELLHGETLKDRIRRSTIQVDELVLIAREVAEALAAAHAKGIVHRDIKPANIFLVDMGGDKPTRKIQAKVLDFGLAKIDGPRGVRDRMSDITATGATVGTLAYMSPEQARGETLDLRSDLFSLGVVLYEMATRQIPFQGVTSALVFVQLLNHPPEPVRDWNDAIPRDLERIILKLMAKERTARFQTAGELEEALARLTDKPATNWLRKAVATVPLVRATDPIARPKRPMRRRSSDSQFEIARDPSGSSPSRSSSPSSTDAQTLRPISLRPPERPREGVSSSGSTPIPESLSSLASVTRERYHPDNDELFGPANLTPDPIAAPPSTESSPAIPDASESSRLSSASRPPTPSADRYPEEEEEVDEVALHLNGDSYRNTLEARRHTRRLRRMRLTAAAIVALTTVGGLFFHFNRGRFGSTLLTDRDLIVVTDITNKTGNKTLDGTLAQALQIDLVQSPFLRIASTDTYRAALHQLGIESVNGLNPVQARSVAEKIGAKAYLKGTIEGDGAPYTIRLSLLSSTNNDQLASVEDRAANLGEIAATVDRLSDDIRANAGEEADSIAQSHVPLAREGTADMAALHAYTLGEDAAIAGRPAEALGFYQQAVALQPGFVQAQLRLVVLYRKQRAEVAAADAARLAQASSANSSERTRAFAQYENEVATTGDLVQATNVIRHFLSERPHDPEALADLARVLRLQGRLAEALQTAQRGYAENPYNLDAYIQAETALLGLDRYDAALQLEEQVHHFGLSRVGGSISAGYLEGRPDIVQKAIADFTSKKPGQRSDWTFGLYMDNSGRMEEGLALWRTSAAAAQQIKGLESGAAYLLAQGALDRALINDCANVAILTHEAAEKPQGMVALFNSGMAAALCRLPEAAVHARDELHRRYPQSTDVNGYMLADLNAALHLEAGDPATALSDLTGARQYDLISLTPYLRGRAHIALKLTQVGIVDYQTVLSHRGITFTIGSNVYPVAEVGVARAFAETGDKNNSADAYRRFLVLWKDADANQPLLKEARAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX34</accession>
    <name>E8WX34_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1542</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579914.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1542"/>
    <dbReference type="EnsemblBacteria" id="ADW68595">
        <property type="protein sequence ID" value="ADW68595"/>
        <property type="gene ID" value="AciX9_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1542"/>
    <dbReference type="HOGENOM" id="CLU_2699539_0_0_0"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8171" checksum="7F6539F852695FAF" modified="2011-04-05" version="1">MIQLDLQPGLEAQLTAKAQNLGLSTVKYVEQIVLSKNEEDDHLQEGLDDIATGRTRPAREVFAELHARYDIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX79</accession>
    <name>E8WX79_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581036.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2697"/>
    <dbReference type="EnsemblBacteria" id="ADW69721">
        <property type="protein sequence ID" value="ADW69721"/>
        <property type="gene ID" value="AciX9_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2697"/>
    <dbReference type="eggNOG" id="COG4299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029171_4_0_0"/>
    <dbReference type="OMA" id="WHGFTFY"/>
    <dbReference type="OrthoDB" id="768508at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="389" mass="43487" checksum="DF03BBC288AD7C58" modified="2011-04-05" version="1">MTEQALGDIQRPSRLLSIDLLRGLTIGFMILVNDAGSERDAYAPLQHAWWNGFTPTDLVFPTFLFLVGITTVLSLGSRMDRNVPRMTLFWSVLRRAVLIYVVGILASTFPFTHLAGMRFVGVLPRIALCYLIVGSLLLISKSWKDKVVILAACLIGYWALLRFVPVPGYGVPTHDVPLLDRDGNLAAWLDRWMFAPQHLYERTRDPEGLLSTIPAVGTALLGLLTGLFLRSQHALRTKIMGIAGAATVSILLGLLWNITLPINKKMWTSSYVLFAGGLSMLLLAACMTLIDIPAERESKLQRSARSRFFTPFLVFGTNAIAAYVLADLLEEILSTIHIAGHSLHHVLWYALRNAIPDIAFASLLYALAYVFVCWLIIYQLYRRKIFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX84</accession>
    <name>E8WX84_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">AciX9_2702</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581041.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2702"/>
    <dbReference type="EnsemblBacteria" id="ADW69726">
        <property type="protein sequence ID" value="ADW69726"/>
        <property type="gene ID" value="AciX9_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2702"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_0"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="43347" checksum="6A02EB0E092F5D91" modified="2011-04-05" version="1">MTPKPENLITVLDAGSHKSCVLVAEVADGVLRYRGHGIEASRGMRKGLIAELGPAAEAINQAALTAERVAKATIENAVVGIGGTHVRGINSRGGISMGSRMREITREEVRAAVDRARSVPLPPDREVLHLLPQEFILDDQAGIHDPVGMVGNRLEVNLHLSTCSGGIAQSVITCANRAGLEVEDTVFEGIASAEAVLSADERELGVCLADIGASTTELAIYFEGSIAHTAVLPIGGDHFTNDLAVGLHVSVEEAEQIKQLYGNCVVTSVPTLAEIEVGGQLAGIGGGGQPARLVRQRFVAEILEPRARELFTMLRDNLRQGGVLEALGAGCVLTGGGANLVGLLDNAESLLRVPARIGIPVPLSRMPQELVKPEFAAAIGMLLYTHRTQIRRAGEEQGLKAKLRSIFAGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD5</accession>
    <name>E8WXD5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ordered locus">AciX9_0396</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578796.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0396"/>
    <dbReference type="EnsemblBacteria" id="ADW67468">
        <property type="protein sequence ID" value="ADW67468"/>
        <property type="gene ID" value="AciX9_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0396"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_0"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="OrthoDB" id="398146at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="931" mass="102259" checksum="8CC7FBE7201CCAA7" modified="2011-04-05" version="1">MPSLWSPASWSSRLEELLSPAGELKGAPLRRDVRSLGMLLGLVLREQAAAGVYESVEGLRLAAIGRRESSDANAGALPSVAAEAADAGRAYQLARAFSFYFELINLAETNHRKRRRLAHQLEDAAPQRGSLRGTLRALKKAGRSGEEIRELLARVQVMAVFTAHPTEVARRSVMFKRRRISELLERLDGIPVPGATLEALERDLTAEITALWQTDDVRAQRPTVRDEIRMALDYYESSLFDTLPVLYGEIEGALAAELGDKVELEDLPLLVTFGSWIGGDRDGNPFVTPATTAEALGAARELLFGHYLKRLQTVFDQLGSSTNQAGVTDELEARLEVYLAELRVAGSQSAEQRFVERFPQERVRLLVACMMLRLGGSPQSSVKLEAPPLAPYTAATELVGDLRVLRASLGAHHGERLAAMLIDPLVVEAKTYGLHLQALDIRQHARVHAAAIEELAGASDVAKVPEALSAGTMEVLETFQMLAKLKREYPAESVARYVISGATSAEDVLNVVRLARVGGVAVEGSESDPGLQPVPLFESIEDLQNAPAICRELWGAAAYKPLLASWGGAQEVMLGYSDSNKDGGMMTSTWEIFKAHRALYEVAAECGVTLRLFHGRGGTVGRGGGPTHRAIYAQPMDSFSGQLRLTEQGEVLNWKYSDVVLAERNLELMIAASLDALGRPKDKGEHLTGVLLPEWERVLDGLSESSYAFYRKHIVDDPETFTYFEQATPVAELEHARIGSRPAKRTDASSAKKRSMEDLRAIPWVFGWMQSRHLVPAWFGVGHALALYEAEFGLDLLQKMFRSFPLFIDIVRNVEMALAKADFGIARLYASLVEDAGLRERVLGTLEREFELTTKMVLAVTGQSVLLERNAVLEQSIRLRNPYVDPLSLLQVELMRRKRGLGEADEVERGNIDRAITATINGISAGLRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP6</accession>
    <name>E8WXP6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="3">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579981.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1609"/>
    <dbReference type="EnsemblBacteria" id="ADW68662">
        <property type="protein sequence ID" value="ADW68662"/>
        <property type="gene ID" value="AciX9_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1609"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_0_0_0"/>
    <dbReference type="OMA" id="EHDLFIQ"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="253"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="446" mass="49699" checksum="43ED5F42B15CCFFB" modified="2011-04-05" version="1">MSNTPAANTEAASIKPHTGKLGVMIPGMGAVATTLIAGVEAIRRGLAKPIGSLTQMGTIRLGKRTDNNSPLIKDFAGLCPLEDLVFTGWDIFGGNLYDAAKTAQVLDRDQLEEIRPFLESIEPMPAVFDQHYVKRLTGQKIKVGKNKCDLANQIRNDIAEFKTKTDRQIMIWCGSTEIYLEQTAVHQTLEAFEKGLVDNDPGISPSMMYAWAALKEGIPFANGAPNLTVDIPALQELSKKMNAPICGKDFKTGQTFIKTVLAPAFKTRMLGVAGWYSTNILGNRDGEVLDDPESFKTKEVSKLGVLEHIFQPELHPDLYKDLYHKVRINYYPPRGDNKEGWDNIDIFGWLGYPMQIKVDFLCRDSILAAPLALDLVLFMDLAARSEKLKGIGIQEWLSFYFKDPDTAPGVYPEHDLFIQSMKLKNTLRHIMGQDLITHLGLDYYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX8</accession>
    <name>E8WXX8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578845.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67517">
        <property type="protein sequence ID" value="ADW67517"/>
        <property type="gene ID" value="AciX9_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0445"/>
    <dbReference type="eggNOG" id="ENOG5030YJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188609_0_0_0"/>
    <dbReference type="OMA" id="RDYAAYC"/>
    <dbReference type="OrthoDB" id="1213607at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233474" evidence="1">
        <location>
            <begin position="22"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="233" mass="25940" checksum="326647B5EB91EC84" modified="2011-04-05" version="1">MQILPSALVPLLLAIPFAAQPAPAKLAKPPKLHVVTLGPLRKVPYTPPDTTPDEKNEDTTTLKIRPLIVDERQREWTIGEPHDVTDRSFTIRRALRLNDALPADREPRWVWQPGPWLLVDRQTGHITALHLPDFDPLVSNAVWFRDYAAYCGTSTAVKGGLFAVVAQLGSRRAIVQRLIGPWPQPNHFIPVCQPATWQRLPVRVTLKPTGGDPMTFDVVGLSSLIEEADTPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY83</accession>
    <name>E8WY83_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580029.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68710">
        <property type="protein sequence ID" value="ADW68710"/>
        <property type="gene ID" value="AciX9_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1660"/>
    <dbReference type="HOGENOM" id="CLU_2649373_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="76" mass="8981" checksum="1339A1E6DF15E6B9" modified="2011-04-05" version="1">MNESSEVRVLRQLILDDERALEALQQRETELLRTIELHDFHAATRRERILSDMQSAETRLRKNRQQLVALGARIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH5</accession>
    <name>E8WYH5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface antigen variable number repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2858"/>
    <dbReference type="EnsemblBacteria" id="ADW69881">
        <property type="protein sequence ID" value="ADW69881"/>
        <property type="gene ID" value="AciX9_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2858"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668627_0_0_0"/>
    <dbReference type="OMA" id="TAMRTIC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233982" evidence="1">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="44198" checksum="BEBD0F903F5CA03B" modified="2011-04-05" version="1">MKFLLVLLLWCAPLMAQTYTFKTIMFEGASQYSQAELLAMSGLSTSKAVTNGDLQTALHKLDDTGFFSKINYKTDGQVLHITLEAIAGSQARKVTYTNFVIDTPEDLNTKVHQRLPAFNGTVPNTGEMEQQVARALEGILQERGIHATVTSIGGAEGDLKYSIASPEVVVGKIAVAGVDLGKDAKLATVRDRILGSPYTEGQSGEALRTNLMDTYQDLGYVNFSMGTIGHGAPVVSAERISVDLTGEAQVGALYIVGQVTAPAAEPRVDRGDLKKANQLKAGAPASRIEVMSTVARLGQVFEGHGYLDEKTSVDATKNDAAHTVSYVFRTVAGESYRFHALKTPGLTEQQDAEVRKSFTLVPGSLYDRSAIGALGTTAMRTICNGSPLRMGLQKDQKTHEVDVMFTCPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP4</accession>
    <name>E8WYP4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578970.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0571"/>
    <dbReference type="EnsemblBacteria" id="ADW67642">
        <property type="protein sequence ID" value="ADW67642"/>
        <property type="gene ID" value="AciX9_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0571"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423758_0_0_0"/>
    <dbReference type="OMA" id="ADWANDI"/>
    <dbReference type="OrthoDB" id="480370at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="416"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="646" mass="70749" checksum="458E1F80059B149A" modified="2011-04-05" version="1">MTETPTIDTPQSGVFDRWAEVYDTQQNPLLSLEERTLTPLLPTALGKHWLDIGCGTGRWLHRLEALEPASLTGIDSSSTMLEHASSKLALQAVLIHGDCSSLPAEDCSQDCLLSSFVLSYLPDLPSFAAECARALKPGGCLLLSDMHPGTARERGWTRSFTVSGETFDIAAESPSLDEIVQAFTSAGFDLVTLLEPSFDAPERPLFERTGRLKEYEALTTVPAIYILKLKKRTPSKLSHRADSIQLTNTTWCIGSKDWQRGTLSTIEGRFAQHTEAPDSVLSSIDLSGFVLLPGLINAHDHLEFALFPNLGRSPSEAPYSNSAEWAREIHKLHAEIIDLHKRVPLETRVWWGAIRNLLCGVTTVCHHNPLHLECTLPDFPVRVVEDFGWAHSLDFAPDIADRFQAASSHLPFIIHAGEGVDVQARSELAALDDLGFLGPHTLLVHGLAFTPDDAALLNQRRTALILCPTSNQFLFHQTPANSFINGIDRVALGSDSPLTAAGDLLDEVNLLYREQHLDAATLFNLVTASPAEMLCLQEGEGHITPGARADLIAVRETPHNPADTLANLSFDQVELVLLAGRVQLASQTLYERLPFHLRDGLEPLEVAGNLRWLRAPITTLFESAEAVLGRGTLRLGGKEVHRVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT2</accession>
    <name>E8WYT2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580087.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1720"/>
    <dbReference type="EnsemblBacteria" id="ADW68768">
        <property type="protein sequence ID" value="ADW68768"/>
        <property type="gene ID" value="AciX9_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1720"/>
    <dbReference type="HOGENOM" id="CLU_2355770_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230471" evidence="2">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="9751" checksum="F56366FBC1A9DE7B" modified="2011-04-05" version="1">MYAVFVIAAILLSASPMHAHTLIAAILPSSTPAQHLAASELTEPRDLAPATRPAPRKVPVPPVFPDRSNASIPAASPAPAVPLSAAALLTHAPNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ26</accession>
    <name>E8WZ26_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="12" type="ordered locus">AciX9_2918</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581256.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2918"/>
    <dbReference type="EnsemblBacteria" id="ADW69941">
        <property type="protein sequence ID" value="ADW69941"/>
        <property type="gene ID" value="AciX9_2918"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2918"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_9_1_0"/>
    <dbReference type="OMA" id="QVRPEMI"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="543"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="552"/>
            <end position="559"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="605"/>
            <end position="609"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="659"/>
            <end position="662"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1082" mass="112810" checksum="CB7FBAAE4198EFF6" modified="2011-04-05" version="1">MSKVRINDLARELEVKSRPILDALEAIGVSGKTHSSSIEEDQAEKVRAYFKNGGRSSSPSRPAQPQAPKFDLSGVSKPGDAMRAILERKQAQDAARNAPPPRPVTVAPPAVAVAPPVRPAVAVAPPVRPVVAAAPPVAVTPAAAAPVATPAPVAPAPVAAAPVMPVAQAAPAPRRIVPLPSQGARIIAPPVVAAPAIASRPPAGPVVAARPPISGTPVAPAVLGKPPVAVAAVAAPPKSAVPVAATPAPAAPAPVAEAPAPVVEAATPAPEAQAPEAPVAPPPPPGPPARRIIMPQTGPRPIYTAPPPVPGAAARRPIFERPRTGPGSGPGTGFAGPGGAGSRPPMGGGMGAPGARRPMHPTRPGFAGGPGGPPRPGFTPGARPGFPARPGFPPRPGGAPGVAPGPGETPTGLRPARPGQRRGGQRYEKVKEGPMKGFQPPPRYGGQPMSREPLPITKTITVTEGISVKDLAEKLDVRGKDLIASLLMKGVFVTVNQSLEGELVKDVARQFGADAIVISVEEQLENEAIEGFLEDTTGMVEVTRSPVVTVMGHVDHGKTSLLDAIRSTDVAGGEAGGITQHIGAYKVKITKPDSPAFGREIVFLDTPGHEAFTRMRARGAKVTDIVVIVVAADDGVMPQTLEAIDHARAAKVPIIVAVNKIDKPEANATKVIQQLAARGVQPANQGGDTEFVEVSAKKRLNLDALEEMICLVADTNEQKAQPDRPAVGTVIEAKLDRGRGAVASILVQNGTLRLGDSFIVGNTFGKIRAMFDDRGRAIEEAGPSTPVEILGLEGMPDAGDTFLVMADRDKAKGIAQYRKMKEREAQLAKSSRVSLEGLAEQIKQAGVKDLNIIVKGDVQGSVEVIAEDLAHMSTEKVRVRVLHSGVGAITESDVLLASASNAIIIGFNVRPDRKSSEVAERENVEIRLHSIIYELRTEIEKAMYGLLDPVFKENYAGRAEILQVFKITKVGQIAGCRVTDGTIKRNAQARLMREGVEVWKGKISSLKRIKEDVSEVREGVECGIDLAGWKDMRAGDVIETYTTEKLADELGANTAESKRKQLAELAAAKATEKEVEAAEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ27</accession>
    <name>E8WZ27_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2919</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69942">
        <property type="protein sequence ID" value="ADW69942"/>
        <property type="gene ID" value="AciX9_2919"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2919"/>
    <dbReference type="HOGENOM" id="CLU_2879572_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="6103" checksum="778F647E4AB845A3" modified="2011-04-05" version="1">MPLDGGLKAPSNPKGKGKGKGKGKGKGKGKGKGKGKGKGKGKGKGKGKGKGKDEGEGEGKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ40</accession>
    <name>E8WZ40_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ordered locus">AciX9_2932</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581270.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2932"/>
    <dbReference type="EnsemblBacteria" id="ADW69955">
        <property type="protein sequence ID" value="ADW69955"/>
        <property type="gene ID" value="AciX9_2932"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2932"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_0"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="72" mass="8329" checksum="B5FE96E67F5EBEEB" modified="2011-04-05" version="1">MSKEDAIEVMAVVVETLPNAMFKVELENKHQALAHVSGRMRKNFIRILPGDRVAIELSPYDLNRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB9</accession>
    <name>E8WZB9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0650</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579049.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0650"/>
    <dbReference type="EnsemblBacteria" id="ADW67721">
        <property type="protein sequence ID" value="ADW67721"/>
        <property type="gene ID" value="AciX9_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0650"/>
    <dbReference type="eggNOG" id="ENOG50349ZJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1872534_0_0_0"/>
    <dbReference type="OrthoDB" id="2049347at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="15007" checksum="24EDB2D1E00C297D" modified="2011-04-05" version="1">MRKLLILLTIILVAFVVINRQRVFLLDPIARVERDGVKVDHAKAMINYSNDVLLMDGSGGKSRVYLVQHWDKEPVAPSVLKCLSGMACLTDDDRATGTPISIGARGNRAPFAGVTMTNRKIEFLDENGALIEVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL9</accession>
    <name>E8WZL9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBS domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2970</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581307.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2970"/>
    <dbReference type="EnsemblBacteria" id="ADW69993">
        <property type="protein sequence ID" value="ADW69993"/>
        <property type="gene ID" value="AciX9_2970"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2970"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_0"/>
    <dbReference type="OMA" id="QHMRIVI"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="49724" checksum="08DAAE1370CA849E" modified="2011-04-05" version="1">MSFVLLAALLLVLAMAAYIDRVYGEMGKFLARNYQDNIDSWEERVEPKLKLGRESVAQSASVLRQLSLAGVSVIFGMQLLATLLAIPGAGWKQVAVTLFELVLVILIFDRLVPQVLFARTRGIWVVKIRYVLQALFYLILPITLLLGLLLSIAALAEPEDTEEEDHPSEAMDALLEAGEEEGILEESDRELVRSVVEFGDKVVREVMTPRPEIFAVPATLTLKEFTELLEQHVFSRVPVYRESLDHVTGIAFAHDLLQITDADAVTRTIAQMQRPAAFVPETKMVAELLREMQSEKQHMRIVIDEYGAVAGIVTIEDLLEAIVGNIADEHDETEEDDAPVREADGAYAVSGGFELSRLRDLFADQFTERAEGAAAPDDEDGEDDRDEPTAVRLPEHYESTTIGGLVSEIAGHIPLPGEVVEGDGLRLEVLASTDRRIDRVRVSLSAVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM4</accession>
    <name>E8WZM4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="8" type="ordered locus">AciX9_2975</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581312.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2975"/>
    <dbReference type="EnsemblBacteria" id="ADW69998">
        <property type="protein sequence ID" value="ADW69998"/>
        <property type="gene ID" value="AciX9_2975"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2975"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_3_1_0"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10261" checksum="686596FB432D4E88" modified="2011-04-05" version="1">MANHVSSLKRARQTIVKTSLNRANKSKLRGTLRILREALAKGDATDLMKVYSNTASILDKSVQKGILHKNTASRYKSRLNARVKTAILAKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU0</accession>
    <name>E8WZU0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0681</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579079.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0681"/>
    <dbReference type="EnsemblBacteria" id="ADW67751">
        <property type="protein sequence ID" value="ADW67751"/>
        <property type="gene ID" value="AciX9_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0681"/>
    <dbReference type="HOGENOM" id="CLU_1169354_0_0_0"/>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="25866" checksum="507C0F559C053B83" modified="2011-04-05" version="1">MVDDSVLRVRFEDGTEATSPVQRFPRLLHATPKERSVWRIIGKGDGIHWPEIDEDISIRSLRGEMPLATASSEKIEEVLKLTGEIYKASHRLREISGGRSFTPDGHFVAAVGKVVAEYIYDLRPVSDDVRFVDAVSSSGASVQIMLAGPTGTKFGIRWSKGSSSSHADILLCLKLTAEGFQEIYNGSFPVELVEGKPAGQVQISVKRLIEHNPALLEKAHSFASINGFLPAQLANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW4</accession>
    <name>E8WZW4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Catalase</fullName>
            <ecNumber evidence="2 9">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">AciX9_0705</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579103.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0705"/>
    <dbReference type="EnsemblBacteria" id="ADW67775">
        <property type="protein sequence ID" value="ADW67775"/>
        <property type="gene ID" value="AciX9_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0705"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_0"/>
    <dbReference type="OMA" id="VMWQMSD"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW67775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="693" mass="75632" checksum="C2CD28706C0404FB" modified="2011-04-05" version="1">MAKLGHEEAADHSIGNGGELHQAAGETHPPMSSQRGLIIADDENSLKANERGPVLIEDHLLIEKTQHFDHERIPERVVHARGYGAKGYFELTDSLEGISKAGVLTRVGEKTPAFVRFSTVAGNAGSSDLARDVRGFAVKMYTPEGNWDIVGNNIPVFFIQDSIKFTDLIHSVKQEPDRGFPQAQSAHDTFWDFVSLVPESTHMLMWIMSDRAIPRSFRMMEGFGVHTFRLINNAGKSTYVKFHWRPKLGMESVIWDEALKISGADPDFHRRDLWNAIDEGNFPEWELGVQLFDEEFAQSFDFDVLDATKLIPEETLPLRIIGKLVLDRNVDNYFAETEQVAFATTNVVPGIDFSNDPLLQGRNLSYIDTQLTRLGTPNYQQIPVNAPRCPVMNMQRDGHHQMLPQKGRVSYSPSSLEADAPRPDAVKGFSSFKAHEEGDKMRVRAASFADHFSQALQFFNSQTEPEQNHIVSAFIFELSKVETKAIRTRMLGQLANVDATIAQRVADGLGMTEPIKPAATTVTVRTDLKVSPALSIVQKMVPGLKTKLIGVLIADGTDAAEVLALETAAGKLGAKVKIVAPKIGGATTSDGKTLEADFQLAGGASVLFDAVFVALSEDGAKLLSTEAAAVGWVHDAFSHLKVIGATSGAQALLDAAGVVPDEGVLVGADADAYLSAAANGRIYDREPNVRTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW9</accession>
    <name>E8WZW9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0710</name>
        <name evidence="8" type="ordered locus">AciX9_4458</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">pACIX903</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67780">
        <property type="protein sequence ID" value="ADW67780"/>
        <property type="gene ID" value="AciX9_0710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71404">
        <property type="protein sequence ID" value="ADW71404"/>
        <property type="gene ID" value="AciX9_4458"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0710"/>
    <dbReference type="KEGG" id="acm:AciX9_4458"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_0"/>
    <dbReference type="OMA" id="IPANAHE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="36373" checksum="DD11EB3386792650" modified="2011-04-05" version="1">MAMKQQTFASQSSFEKYGRKSRRELFLDEMEVVVPWFELQALIEPHYPKAGNGRRPVGLAIMLRTYFMQQWFNLSDPGVEEAFYESATLRRFAGVDLGVAPAPDETTVLRFRHLLEKHDLGGAILDAVNLHLAAKGIRIETGTIVDATIIHAPSSTKNEKKERDPAMRQTRKGKQWYFGLKAHVGVDAKEGHVHSVATSAANVSDVHMLPDLLHGEERKVWGDGGYQGQTKAIRQAAPKAQDMTCKRTRFKTYVDEAAKKKNTTKSKVRAKVEHVFRILKRVFGFDKVRYRGIAKNHHRLCTNFALINLYLHRKHLAGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY2</accession>
    <name>E8WZY2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579119.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0723"/>
    <dbReference type="EnsemblBacteria" id="ADW67793">
        <property type="protein sequence ID" value="ADW67793"/>
        <property type="gene ID" value="AciX9_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0723"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="PQMDGNE"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="154" mass="16925" checksum="A75831AF58CB8C27" modified="2011-04-05" version="1">MRPKKVILCVDSNEQTLSVRTFLLETRGYRVISSQTAQGALEILEQTEQGTMDLLIADLLLPQMDGNELVRRAKQMHPMLPALIVSGTVTSFDRALAADAFLPKGACSAVELLEKIRVLVARKRGPKKHVARHVPEMVEQVSQDAGLHLTAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X038</accession>
    <name>E8X038_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1888</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580253.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1888"/>
    <dbReference type="EnsemblBacteria" id="ADW68934">
        <property type="protein sequence ID" value="ADW68934"/>
        <property type="gene ID" value="AciX9_1888"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1888"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_0"/>
    <dbReference type="OMA" id="ITHFHTP"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="50027" checksum="17E9B948B2C93C58" modified="2011-04-05" version="1">MFRKVLIANRGEIALRVISACKEMGIRTVAVYSEADRNSLHVRFADEAICIGPARSAESYLNVPAVISAAEIADVDAIHPGYGLLSENANFAEVCRASNIKFIGPPPEVTRMMGEKSTARQTMKKAKVPILPGSDGVIANEDEALEWARSVGYPVILKAVAGGGGRGMRICRNAAELPSMYQQASTEAANAFGNGDMYMEKFIERPRHIEFQVLADEHGNVMSLGERECSIQRRHQKLIEEAPSLQITPKLRAELGKVIERSLKDIGYWNAGTIEFLMDEDGKIYFIEMNTRIQVEHCVTEMVTGVDLVKAQLRIAMGEKLSDIVPKVPEIRGHAIECRINAEHPEKFTPSAGKITAFNLPGGNGVRVDTAQYAEGVVPPYYDSLIAKLICHGKDREEAMDKMQRALSQFVVEGIHTTIPLHKKIFADPEFRSGQFDTKFMERFFERQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X084</accession>
    <name>E8X084_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3045</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3045"/>
    <dbReference type="EnsemblBacteria" id="ADW70065">
        <property type="protein sequence ID" value="ADW70065"/>
        <property type="gene ID" value="AciX9_3045"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3045"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_0"/>
    <dbReference type="OMA" id="YCDGGYS"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="187"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="37541" checksum="60D226C6672F3C63" modified="2011-04-05" version="1">MTQSVGYAAQNVAAPLERFDFTRRDPGPADVVVEIAYCGICHSDIHQVRDEWGGSMYPMVPGHEIVGHVTAVGADVTKFKVGDLAGVGVMVDSCKVCANCKASEEAYCEKGFVGTYNAKGYDGKLVFGGYANNIVVDERYVFSISPKLEAKLAAVAPLLCAGITTYSPLRHWKVGPGMKVGIVGLGGLGHMGLKFAHSFGAHVTLFTTSAGKEADAKRLGADEVVISKDADAMAKQKSSFDFILDCVSAPHDMNTYLGLLRLNGTLCLVGLPEEPLSISAFSTVTNRRSLAGSMIGGMTETQEMLDYCAEHDIVSDIELTSVDKLDEAYERVVKSDVKYRFVIDLATLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X096</accession>
    <name>E8X096_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="8" type="ordered locus">AciX9_3057</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581391.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3057"/>
    <dbReference type="EnsemblBacteria" id="ADW70077">
        <property type="protein sequence ID" value="ADW70077"/>
        <property type="gene ID" value="AciX9_3057"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3057"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_0"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="34292" checksum="6875E3993DC700EC" modified="2011-04-05" version="1">MANITMKELLEAGVHFGHQTKRWNPKMKEYIFGERNGIYIIDLQKTLKMFKEASKFVTDLTSTGKLILFVGTKRQAQDAVAEEATRAGMPYINSRWLGGLLTNWVTVQKSVKRLQELDDMSTDGRYELLTKKEVIKLERERKHLATNLSGIKAMKRLPDALFVIDSNNEAIAVAEARKLGIPVVAVVDTNCDPTVVDYVIPGNDDALRAIRLFTMKMADSAAEGVQMVSERAFATESADVRELPTESHFIGEEGEEIEAPVQESTGTAEASVEDAESEVIDLEAALGGGIKKAPAAATEPEPEAEAVHAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K2</accession>
    <name>E8X0K2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate formimidoyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1907</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580272.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1907"/>
    <dbReference type="EnsemblBacteria" id="ADW68953">
        <property type="protein sequence ID" value="ADW68953"/>
        <property type="gene ID" value="AciX9_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1907"/>
    <dbReference type="eggNOG" id="COG3643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040037_0_0_0"/>
    <dbReference type="OMA" id="DEDHNRL"/>
    <dbReference type="OrthoDB" id="780971at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD" evidence="7">
        <location>
            <begin position="183"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="306" mass="32930" checksum="6FA97F1B2FB60CD3" modified="2011-04-05" version="1">MTPDAIIECVPNFSEGTHPDIVRHIVSAMQVDGVRLLDYSLDPDHNRSVVTIAGPPAQVMEAAVLAAGKAAQLIDLTQQTGVHPRIGAADVIPFVPVSGLSLAEAAMLARQAGLQIWRRFGVPVYFYGAAAARPDRVQLEDVRRGQFEGLREAALKDAARRPDVGGPELHETAGASVVGARSFLIAYNIYLDERAEITQARAIARDIRASSGGMQGVKAIGVLANGRAQVSMNITDFHLTPMPKIHSTVAELARRHGTSLGEGELIGLIPAAAYDAEARWIKEIPSFDPEQKIIENRLNNPMAWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M6</accession>
    <name>E8X0M6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1931</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580296.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1931"/>
    <dbReference type="EnsemblBacteria" id="ADW68977">
        <property type="protein sequence ID" value="ADW68977"/>
        <property type="gene ID" value="AciX9_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1931"/>
    <dbReference type="eggNOG" id="ENOG5032WSP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268515_0_0_0"/>
    <dbReference type="OMA" id="IREEWIS"/>
    <dbReference type="OrthoDB" id="288336at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230531" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="803"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133919" checksum="15FE477006A7AEAA" modified="2011-04-05" version="1">MASRSFLSGLLAVGMTATALHVANAPAAPSLQDTPAASHGSTALNRGRKPALSMPSWSDQLDRDPSTAGEASAAKDFAETLCPEPGAATRICIPDGTGLQPAAADMQANVVFAIVPDPIHTHLALWFDRSIDSLEDGLTDSGWRYDRNWLPWSLDPVSPSSVKFKDREQERLFLSKREDYPGIIIFRPPPLPQVPPEAALPAQVPGEIDPQKPLVVFVIGDSPTSGVNQTQFQKAVGQFHRIAAGLQTLKIIGPTFTGSGPSLSALLAEAKKKDLAAVRVNIASGSVSDGRCGNLLDHGRLQEVEKDLFQCNDASVWPHAVDTFASFDADFVWQIRQTERYLMEKGGLRPDEIAQLNEDESSFGGLATSEVSDPTAISKTSEKEKRILKLTYPRNISHLRSAYQKNGVWGFGGTSSGTGSISLNLDFDDTSEADDSVPSFAKGQLPVSQEATLGQVSAILEQRHIKAVILSATDVLDELFVAQIIARQNPTIAIIIRGTDDLFLRSGDRGVYHNMYAVSPWPLIPKNAIWSQQGLEEHPGVNVRVFASSEIEGLYTATRFLLPGSRALDTLQDYRSPIQAKEGQGAWPHRPPLWLLAIGHGAYWPFALLPEGAGPADAAEAAKGRSPFNLPILSGVAKPVGLDPDAEPLPTTTQFMIFVLCMLCLLHAGKCFDVGVLRRVAPRYRISEPAVRAPKRWLQIALSVDAALILALMAHPVAHLNFVHYLCLLGEAALCAALVWSAFDLLPARFHVKPRRTHAILAVVGCILFCLDLLAWRQLWHFLPPSTLQPDGLREFFYYRSHFALSGASPVFPLVLALTGIGIYLLAQLDRFTFGPRLAPRLPGDVSGISNCPSEASVGYLTGLLSYPAPSLGVMRTKFSILCGLAVLAAICGALAHLAPLTFDGWHLRVCADAVMFLLLITIFWDLVMGHYLWRQLKDVCLEPLELSALRRGFNSVSGMTWQDLWIMPQSHTSLRQYQSFIRALEQTERAGLGHVAGLARLKTNAERLWLRRAEGASLDEITRRFSLVQRLTARVAETVLHQQHTAWAGERVRTTAADEPGPLSESEEAETIRPSDPALADAQQAVSPVIREEWISLIFLHYIRMVLTHIRSRLLTAAILYLILVWSITSYPYLNRHVLLIALSVVFGILAVVIVTTYASINRDPILNRTTKNKANKLDFDFYFKTVPIIGLPLLGLIASQFPEISSFVFSWLEPSMAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M7</accession>
    <name>E8X0M7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1932</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1932"/>
    <dbReference type="EnsemblBacteria" id="ADW68978">
        <property type="protein sequence ID" value="ADW68978"/>
        <property type="gene ID" value="AciX9_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1932"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_6_3_0"/>
    <dbReference type="OMA" id="IHDHVGW"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234239" evidence="4">
        <location>
            <begin position="30"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="106"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="333"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="639" mass="71299" checksum="BF7C095AB15BC780" modified="2011-04-05" version="1">MLVSTSGLTPRLTHGLLASALLLSTAAFGQVLRPAGSGEVDTTATQTATFTQGTTVLEGADRRPQTSLDGAWHSIADPYFTGLYNFHHEMKKDGWFKNEHWAGIGDNRLLEYDFAKSPTLNVPGDWNTQRDSLFLYEGAVWYQRDFTWHNTTGKRTFLHVGAANYRSWFWVNGQKVCQHEGGFTTFDCDVTAALKDGSNFIVAAVNNQRLPEGVPTLETDWWNYGGLTRSLALVEVPEAFITGYDLHLDRATRTHIEGWVQVANAHAGEEVGVSLPELHATTMAKVDADGHAAISFTPKNLKLWSPGKPVLYKVDLTAGNDAIHEEMGFKTIETRGTQILVNGDPIYLRGISIHAEAPYRTGRANTQKDMDTLLGWARELGCNYVRLAHYPHDEKMTRTADRLGILVWSEIPTYWAIQFDNPIVLAKAKQQLNEEISRDRNKVSIGLWSIANETPATEARTKFLTALAEETRRLDKERLVTAALLVRDGDKSKHEKVVDDKLGQALDVIGMNEYVGWYEGKPETADLMQWTVAYQKPVIVSEFGGEGPAGVHGTADQRWTEEYVANLYTHNLKMLAAIPQVRGMSPWLLMDFRSPSRQMPGMQDYFNRKGLISEKGQKKLAFGVLQNAYRSGYGNAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P4</accession>
    <name>E8X0P4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1949</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580314.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1949"/>
    <dbReference type="EnsemblBacteria" id="ADW68995">
        <property type="protein sequence ID" value="ADW68995"/>
        <property type="gene ID" value="AciX9_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1949"/>
    <dbReference type="eggNOG" id="ENOG5032TKD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078752_0_0_0"/>
    <dbReference type="OrthoDB" id="1451505at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="33965" checksum="098500C927DBBAE9" modified="2011-04-05" version="1">MRVFLSWSGPKSRAVAELLKKYLPSLNNTVDPWLSSKEISTGARWSSEIAANLEAANIGVICVTAENQNEPWILFEAGAVSKLTTVGRAMVLRIGMKATDITGPLSQFQSVGTERDDIWKLVVDINGAAAGNAVPESTISLTFNAIWPTLQGELDQVTKQASADAPERSQDEIMQELLTLARRQEQSSQLLLNQIVAVSERTIVTLESRALERRYEEEQYSVEIARLKAREHDLQKRLALWEQTPAKSVGTGPQSLAVIQANVVKLLRERGFAVPSEIWKQDDEGESRLIVNGQIRTLTSLMKELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X164</accession>
    <name>E8X164_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0862</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579255.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0862"/>
    <dbReference type="EnsemblBacteria" id="ADW67930">
        <property type="protein sequence ID" value="ADW67930"/>
        <property type="gene ID" value="AciX9_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0862"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033519_0_0_0"/>
    <dbReference type="OMA" id="ERLWANE"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="269" mass="30273" checksum="F1DE76781F1FE564" modified="2011-04-05" version="1">MNILVLSPHRDDAAFSLSLSIAHWLSAGHRVTLLNVFTRSLYAPYSDADFVHDNDRLSYISAMRRKEDESFLKRLPGLTMVDLNLKDAPIRLRCDASIVCDMDADPADTAIPKIQKALTTQAAAPRPMQALVLPLGLGHHVDHRVARDAALTFSTTLPTAFYEELPYATREGVRVDLSRFREDVNTRLHEPLHPVLVHGTNTHPTDFKLRIAHLYASQIDDDLAHTIANFSHRYQGAERLWANEQWLAKAVDNKLSTSQRDQEAKPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L1</accession>
    <name>E8X1L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3235"/>
    <dbReference type="EnsemblBacteria" id="ADW70246">
        <property type="protein sequence ID" value="ADW70246"/>
        <property type="gene ID" value="AciX9_3235"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3235"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_13_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13655" checksum="319DA275820A6322" modified="2011-04-05" version="1">MQTLKWNDLKHKVSAKERERIKQEAVAELDAMGFAALRKARQQTQVELAEKLGIDQASVSALENRSDLLLSTLAKYVRALGGNLEIRAVFPEAAFNLEPLLALEPATQTKALQTKRARRGASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L8</accession>
    <name>E8X1L8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3242</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581565.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3242"/>
    <dbReference type="EnsemblBacteria" id="ADW70253">
        <property type="protein sequence ID" value="ADW70253"/>
        <property type="gene ID" value="AciX9_3242"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3242"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506025_0_0_0"/>
    <dbReference type="OMA" id="WGLEYLI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="201"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="538" mass="57783" checksum="8DE601005BBD2826" modified="2011-04-05" version="1">MASYPPPYPPPPVGPPFNYDPRQQRRFEKDQRRAQKNAYQAQRDLYRQQTRAMRRGSILGPLMIVGVGVVLLLIRSGHISFEHFAAEYGQWWPALLVIAGVILVLEWTFDQSRQRDGVPYVRRGVGGGVIFLLILLALAGGMMHQISRGHEWIDSMHMGPDNFAEFFGEKHDREQQVDETFTAGTSLNVVNPHGDVTIVGHSEDGQIHVTVNKQIYSNSDSAADEKAQQLSPRIDRSGNVLSVTMPSLDGTTADLSIQMPDSGQATVTANHGDVHVSGMKAPVNVSATYGDVEFNEVSGPVMARMEHSGSSFTAHNITGDLSLKGHAENLMITDVSGQTTLEGDFYGDTHLEHLHGPVSFKTSRTQWTLAGLEGAVDMSSESELTASSVVGPSVLSTRSRNIAVDGIAGDLSVTNSNGTVDVSNASPLGNITIQNKNGAVDVTLPAHGGFSIQADDHDGDIDNDFDMPSRDGDDNHTLTGTVGDGHAKIILRTNHADLGIHKADMKPTAPPAPPAPPAPPAPHVKPAPHAPSAKTVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M7</accession>
    <name>E8X1M7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0878</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579271.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0878"/>
    <dbReference type="EnsemblBacteria" id="ADW67946">
        <property type="protein sequence ID" value="ADW67946"/>
        <property type="gene ID" value="AciX9_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0878"/>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119034_1_0_0"/>
    <dbReference type="OMA" id="VCMETEL"/>
    <dbReference type="OrthoDB" id="1973782at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="19758" checksum="B42AE20529E2D4B7" modified="2011-04-05" version="1">MLIAESIREFFRRNVLRPLLLQLRGGVTPRRLAWSLAVGIVIGINPSVGLTTVLVVMLAWVFGLNQVASQIGLHVMAPIHLLLFLPFIELEVFLFHTRRLPLSRRQLEHLSHHPLRMVRDIWLWEWHALVVWVVVAAVLMPVLAVYIRWGLVLLMRRHRALGRVEAVVDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R8</accession>
    <name>E8X1R8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ordered locus">AciX9_0920</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579311.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0920"/>
    <dbReference type="EnsemblBacteria" id="ADW67987">
        <property type="protein sequence ID" value="ADW67987"/>
        <property type="gene ID" value="AciX9_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0920"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_8_0_0"/>
    <dbReference type="OMA" id="EVQSTTI"/>
    <dbReference type="OrthoDB" id="2030025at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9375" checksum="2C74C8EB4F8CBA91" modified="2011-04-05" version="1">MAKTMAVVDQPSTGLQQLKSGPARLGEFLHDVRSEMKKVITPSRDEVQSTTIVVIITVFIFAAYFALVDFAVGHTIDVLFKHLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T9</accession>
    <name>E8X1T9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0941"/>
    <dbReference type="EnsemblBacteria" id="ADW68008">
        <property type="protein sequence ID" value="ADW68008"/>
        <property type="gene ID" value="AciX9_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0941"/>
    <dbReference type="HOGENOM" id="CLU_3382105_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="33" mass="3755" checksum="FF223CB17CB404CA" modified="2011-04-05" version="1">MDSGKSWLRVEVIVDWKLFLSMTLGALVLYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U7</accession>
    <name>E8X1U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal transport/detoxification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580425.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2063"/>
    <dbReference type="EnsemblBacteria" id="ADW69108">
        <property type="protein sequence ID" value="ADW69108"/>
        <property type="gene ID" value="AciX9_2063"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2063"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_5_1_0"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7038" checksum="6333FB0465F5A157" modified="2011-04-05" version="1">MTTLRIENMHCAACIRRVTQALNSLPNTTVEEVQLGAARIETQATPDQIQAAMQKTGFPTHIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W5</accession>
    <name>E8X1W5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2082</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580443.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2082"/>
    <dbReference type="EnsemblBacteria" id="ADW69126">
        <property type="protein sequence ID" value="ADW69126"/>
        <property type="gene ID" value="AciX9_2082"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2082"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="24902" checksum="CD1E55CC56342AC8" modified="2011-04-05" version="1">MPRINFQQQLVALKDKLLAMAALSQQALEFSVEAYSTRDLALSNHVKEIEAAINAAETSVDEMAYELLAKEQPMAVDLRFILSVIKINGDLERIGDQATNIATRAAAALDKPAIHLPIDIEEMGAKVGVMIRRAIQALLEADDKLAESVLALDDEIDEMNRAIHADLIQTMEQHSESAEQALNAIIISRNLERAADHATNIAEDVIFWVRGNDVRHKFSLLQPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D7</accession>
    <name>E8X2D7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1003</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68069">
        <property type="protein sequence ID" value="ADW68069"/>
        <property type="gene ID" value="AciX9_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1003"/>
    <dbReference type="HOGENOM" id="CLU_2734374_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="8182" checksum="A77AE3AED34F432D" modified="2011-04-05" version="1">MIEKNRFKCTRLPRLSSIELAEYRTRQEAVIANGVAQITRNNEELVRRGILDADWNLIEPFGPLDGPSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M4</accession>
    <name>E8X2M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581633.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3310"/>
    <dbReference type="EnsemblBacteria" id="ADW70321">
        <property type="protein sequence ID" value="ADW70321"/>
        <property type="gene ID" value="AciX9_3310"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3310"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542645_0_0_0"/>
    <dbReference type="OMA" id="HFQSAFL"/>
    <dbReference type="OrthoDB" id="224662at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="PTHR44366"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="502" mass="55122" checksum="0A99387EA75F0179" modified="2011-04-05" version="1">MGRSASNEESQATKKADRESAVETLAPLSLPANVLRILPLPFEVIHNAGERNQIRQAMAAFADELRDEITVVLAQSNLGPVIVSARSLPSPGTGSFSLLKTVAREFEASLLLRVTLRYTGTATRIFMQMLDGEDLKSIWSHRLDRESTARSSTLTWFPVTALADAVREHAGRRRGAATQPAADKDSLSLSAYNLGVHYWNQRSRTTLPKALTYFEDAVALNPNCAEAYAGLANAYVSVSFNDLIPPRDAALKAYEAVQKAVKLNKDSLPVRTALVNVLTNCTWDWARAEQECRASVEAGVMDARMIQLYSSLVGCQGRHEEALSLAMHALRLDPEIPASHSQIAQAYLYAGDYANALNSAKKYLMVRPDFATAHALLTRILAVSGDWDGALTECQTAVEISGRSPSSLALMAYVQAGRGDVQAANSMLDLLRTEVTGDFFPSYEVSAVHAALKQEGQAIEQLYTACRQRDMKTIHMNYDPRFEHLRTLPAFQELATIQTQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R9</accession>
    <name>E8X2R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GatB/YqeY domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3358</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3358"/>
    <dbReference type="EnsemblBacteria" id="ADW70366">
        <property type="protein sequence ID" value="ADW70366"/>
        <property type="gene ID" value="AciX9_3358"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3358"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_2_0"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="18013" checksum="3BAF26D3F0D128CF" modified="2011-04-05" version="1">MSELMISERIGKDIIVAMKAREEHRLTTLRMVKSAMKNKEIDKREPLTEAEEQQILTTLIKQRKESIESFTKGDRPELAAREAVEIGMIEGYLPQEASEEEVRTTIMGALEHLAADNDGIRPGPKDMGTAMKVIRQRLLASGIRADGKIVSEILKAELNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V0</accession>
    <name>E8X2V0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1021</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579407.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1021"/>
    <dbReference type="EnsemblBacteria" id="ADW68084">
        <property type="protein sequence ID" value="ADW68084"/>
        <property type="gene ID" value="AciX9_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1021"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_0"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="40698" checksum="B9F0BF867FC1E7E7" modified="2011-04-05" version="1">MRDVVIVSAVRTAVGKFQGALSELSATQLGAYVVREAVLRAGLPPAEVNECIMGCVLPAGLGQNPARQAALGGGLADSVAALTINMVCGSGLKAVALGAQAIMLGDAEIVVAGGMESMSNAPYLLPQARKGYRMGDGKVVDSMVKDGLWCACDDQHMGMTGELVADKHSITREEQDAYAVESHRRAANAWAEGRFAAEVMAIETPGKKGTVTVFDHDESIRPDTSLELLAALKPAFKKDGTITAGNAPGVNDAAAALVLMSAEKAKALGLRVLVKIKAQAQSGVAPRWVMLAPVLGVERVLKKAGWSKDGVDLFELNEAFSVQALGVTRELGLDLNKVNVNGGAVAIGHPIGASGARVLVTLIHEMLRRDVHRGVAALCLGGGNSVALAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z3</accession>
    <name>E8X2Z3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1064</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579450.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1064"/>
    <dbReference type="EnsemblBacteria" id="ADW68127">
        <property type="protein sequence ID" value="ADW68127"/>
        <property type="gene ID" value="AciX9_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1064"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327723_0_0_0"/>
    <dbReference type="OMA" id="VRFFACE"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10536" checksum="CEC380E9B0DE36D6" modified="2011-04-05" version="1">MIRVELPAPLCRLAGCEREVTLEVRVATLGGVMDALEEQYPALRGAVRDYATGERRAYLRFFAGEEDISAMRSDEALPDAVARGDEALLVIGAIAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A5</accession>
    <name>E8X3A5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3400</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581718.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3400"/>
    <dbReference type="EnsemblBacteria" id="ADW70406">
        <property type="protein sequence ID" value="ADW70406"/>
        <property type="gene ID" value="AciX9_3400"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3400"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_0"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="410" mass="43953" checksum="60FDE0F9B9189843" modified="2011-04-05" version="1">MPTADLASETTAALTASELIALEDQYGAHNYHPLDVVITHASGAWVTDIDGKRYLDFLAAYSAVNQGHCHPAILAAMIEQARKVTLTSRAFRNDQLPLLYRDLHALTGFEMALPMNSGVEAVETAIKAARKWGLTVKGVPAGTAEILVCGNNFHGRTIAVVGFSSESQYKCGFGPFPTGFKQVPFGDVEAIRASIKPNTVAILVEPVQGEAGIIVPPAGYLRELRELCDEHDLLLMCDEIQSGLGRTGKLFAFEHDNIRPDVCIIGKALSGGFYPVSAVLASREILGVFTPGDHGSTFGGNPLACAVARAALKVLVDEDLPARSADLGAYALARLQSLNLPQIVAVRGKGLWIGLELNIKARPICEALKDRGLLCKETHDTVIRLAPPLMISKEDLAWGLDQIEAVLKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C8</accession>
    <name>E8X3C8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581741.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3423"/>
    <dbReference type="EnsemblBacteria" id="ADW70429">
        <property type="protein sequence ID" value="ADW70429"/>
        <property type="gene ID" value="AciX9_3423"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3423"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129722_1_0_0"/>
    <dbReference type="OMA" id="DQSCVKI"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="14907" checksum="1A5690AE7B061046" modified="2011-04-05" version="1">MMMDSSRPEVASSLLPIRTPEDIVLVRTAVRKAALGIKFGLVDQTKLVTAASEIARNTLDYGGGGTVAIELLQDPKTGVRLRFEDQGPGIANIDLALTDGWSSGNGMGLGLTGTRRLMDDFDLASKLGEGTTVTITKWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G6</accession>
    <name>E8X3G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3462</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581778.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3462"/>
    <dbReference type="EnsemblBacteria" id="ADW70467">
        <property type="protein sequence ID" value="ADW70467"/>
        <property type="gene ID" value="AciX9_3462"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3462"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018558_0_0_0"/>
    <dbReference type="OMA" id="YDDAMAY"/>
    <dbReference type="OrthoDB" id="1715851at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233626" evidence="3">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="271" mass="29437" checksum="8F8E30986267C3F6" modified="2011-04-05" version="1">MKLIARVPVTAGLLALSLMSATGCNRLRAADQLNKGVAAFKNAKYEDATNYFQNAVNIDPNYDMAKLYLATTYSSQVVPNLNTPENLKLANNALAGFKEVIAKDPSDVTALSQIAYIDRITGHIKEAKEDERKVIAVQPNNAEANYTIGQVDWKEAFDNATIAVKTQGLPGDDGEGNTKLSKPNCAALAAKNGPLVTEGLEYLNKAVGINPNYEEAYTYLSLMSRRKADLECGNDAARKADLQAADMYAQKSMGARKENERIKEEKSHGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H1</accession>
    <name>E8X3H1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1099"/>
    <dbReference type="EnsemblBacteria" id="ADW68162">
        <property type="protein sequence ID" value="ADW68162"/>
        <property type="gene ID" value="AciX9_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1099"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_0"/>
    <dbReference type="OMA" id="MAFGRWI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37577" checksum="B82F3AFF30F35BA8" modified="2011-04-05" version="1">MGWTGGVRIGAYQAGSRGILVTMMTTKVLGNSDMALTAVGFGAWAIGGADYAFGWGSQEDTDSIGAIRKAVDLGVNWVDTAAIYGLGHSEEVVGQALKEIGGKKPYVFTKCSMRWNEKREIYRSLTAEGVRWECEQSLKRLGVETIDLYQIHWPDPDAEIEEGWGEMQKLKEEGKIRWAGVSNFSVAQMKRAQGIGVITSLQPPYSLINRRVGAEVLPFCLENGIGVINYSPMVSGLLTGKMTAERLSKMADDDWRKKSPNFNEPKLSKNLSLADLLGEIGKKHGVETGVVAVAWTLNNPAITAAIVGGRNAEQVEGTSKALTFRLTGEEIAEIDSFVKTNEIGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I3</accession>
    <name>E8X3I3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1111</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579497.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1111"/>
    <dbReference type="EnsemblBacteria" id="ADW68174">
        <property type="protein sequence ID" value="ADW68174"/>
        <property type="gene ID" value="AciX9_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1111"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130244_0_0_0"/>
    <dbReference type="OMA" id="FHINSHT"/>
    <dbReference type="OrthoDB" id="1684599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036929">
        <property type="entry name" value="DsbDN_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74863">
        <property type="entry name" value="SSF74863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230198" description="DsbC domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="2">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18252" checksum="8A98C603BCFAC946" modified="2011-04-05" version="1">MRLLLLAMALAAPLHAQTLSGQDFSNFDKPQESPAKRQQVTYIAEQQIVQANKPAVLELRFQVREGYHVNSHKPLSELQIPTELTLDAAPGLKPAAPEYPAGKPYKIGSGDLAETLDVYTGDFTIRLPVQSTPGPHTAAATLRYQACDRAACYPPKTLKLEVPFTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K0</accession>
    <name>E8X3K0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="7">FBPase class 1</shortName>
            <ecNumber evidence="7">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fbp</name>
        <name evidence="11" type="ordered locus">AciX9_1128</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579514.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1128"/>
    <dbReference type="EnsemblBacteria" id="ADW68191">
        <property type="protein sequence ID" value="ADW68191"/>
        <property type="gene ID" value="AciX9_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1128"/>
    <dbReference type="eggNOG" id="COG0158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_2_2_0"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="945770at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="10">
        <location>
            <begin position="199"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="35045" checksum="196C435049F3E101" modified="2011-04-05" version="1">MAKITTVQQHIAKQHEEFSEEGVTLGWLMGGLTLATKMIEAKIRSAGLTDVYGAFGAENVQGEQQQKLDVYANEALMDSLGARGSVAALVSEEDEAPVTFDRTIEKGKYIIVFDPLDGSSNIDVNVNVGTIFSVHQRLPAAEGTLAESILQPGTKQVAAGYVVYGPSTVLVYTTGHGVHAFTLDPTIGAFVLTAEHMKMPDKGPYYSVNEANAGTWPEGYEAYVTSLRTTGYSSRYIGSLVADFHRTLLKGGVFLYPPTKKQPGGKLRLLYEANPLAFIAEQAGGLASSGSGRILEIKPEGIHQRTPFMVGSKSEMEAFQKALYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M9</accession>
    <name>E8X3M9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1157</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1157"/>
    <dbReference type="EnsemblBacteria" id="ADW68220">
        <property type="protein sequence ID" value="ADW68220"/>
        <property type="gene ID" value="AciX9_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1157"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_0"/>
    <dbReference type="OMA" id="MQIMHGG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="38139" checksum="CDDAD0C651F28452" modified="2011-04-05" version="1">MGGILSKLLEPLKVGALTLPNRVVMAPLTRLRGTVDHLPTAIMAEYYAQRAGAGLIISEGTPVSPMGVGYPQVPGIWSKEQTELWKPVTDAVHEAGGRIFAQIWHVGRVSDPLYLGGKVPVSSSAIAPAGTVTLLRPKKEFGVPRALANDEIKHVIEEFRQGTQNAKDAGFDGVEIHGANGYLLDQFLHSGSNERDDEYGGPLENRARLHLEVAEAASSVFGADRVGMHLAPRGDVMSMSDENPHEAFVYLAGQLGKLGLAFLCAREYFGDDRLGPELKKAFDGVYIANEKYTQAQAEHVIEAGEADAVAFGKLFISNPDLVERFAAGAELNEPDVPTFYTHDAAGYTDYPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X8</accession>
    <name>E8X3X8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydro-3-deoxyphosphooctonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonic acid 8-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KDO-8-phosphate synthase</fullName>
            <shortName evidence="6">KDO 8-P synthase</shortName>
            <shortName evidence="6">KDOPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyoctonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kdsA</name>
        <name evidence="8" type="ordered locus">AciX9_3481</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the KdsA family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581797.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3481"/>
    <dbReference type="EnsemblBacteria" id="ADW70486">
        <property type="protein sequence ID" value="ADW70486"/>
        <property type="gene ID" value="AciX9_3481"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3481"/>
    <dbReference type="eggNOG" id="COG2877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036666_0_0_0"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019294">
        <property type="term" value="P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00056">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="279" mass="29724" checksum="5BCADBBC020FBBCC" modified="2011-04-05" version="1">MKLPEKTFEIGPIAVGRGKLFLIAGPCVLEGESHARGLAEAVQKIAAEVGIPYCFKASYDKANRTSIKSFRGPGLVEGTRILRAIAKDTGLPVLTDVHTPEDCARLSDAVGDVELMMQIPAFLCRQTDLLIAAAETGRAINVKKGQFVAPGDMRHAVQKVRDSGNERVSLCERGASFGYNNLVVDMRALPIMREFAPVIFDGTHAVQTPSAGNGVSGGQPEFIPVLARAAVAAGVDGVFLEVHDNPAEAKSDGANALRLDRLKGVLEELVAVHEVVGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G0</accession>
    <name>E8X4G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68287">
        <property type="protein sequence ID" value="ADW68287"/>
        <property type="gene ID" value="AciX9_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1224"/>
    <dbReference type="HOGENOM" id="CLU_215851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="41" mass="4092" checksum="DC0EE5E74C65E7A1" modified="2011-04-05" version="1">MPLDGGLKPPSNPNGNGNGNGNGNGNSNCNCQYGGSELRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G7</accession>
    <name>E8X4G7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M56 BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1231</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579617.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1231"/>
    <dbReference type="EnsemblBacteria" id="ADW68294">
        <property type="protein sequence ID" value="ADW68294"/>
        <property type="gene ID" value="AciX9_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1231"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625455_0_0_0"/>
    <dbReference type="OMA" id="QIALHEC"/>
    <dbReference type="OrthoDB" id="1551443at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="78"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="430" mass="46915" checksum="0657A729BC0D5F5A" modified="2011-04-05" version="1">MLPLLQHLSASAAASLITSTVEAALLAISVAICLRLIPDLSATVRSILWTAVFLVAAALPFLTPTASGSPSTSTATPIALSIDWAIGIAAFWAALSLFRIAQLLRSAVHLNGVARRSELIISDAASHAPIATSTEIDIPCVAGFFAPRILIPTSLYAALPPSELAQIITHEQAHLNRFDHWTNLLQKLLIALYPIHPVLLWIERRLCIERELACDDAVLRQTGARKQYALCLTNLAENGLARRGFTLALRAWERQSELTRRVLRILEVPTRQLRPTQSAAVVATLLAALTTGATTLAHTPQFISFSTPEAPQSLHESLRAPSIAELHRDGWDVNSHPATFTPTTKPTMVNTSMELPTKPKKSLTKLKPTKKHSTPITQAALRQTQPQQWIMLTTFQSTEAPAHYHQAIFQISDATYAAVPTQAGWLIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I3</accession>
    <name>E8X4I3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580709.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2356"/>
    <dbReference type="EnsemblBacteria" id="ADW69393">
        <property type="protein sequence ID" value="ADW69393"/>
        <property type="gene ID" value="AciX9_2356"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2356"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1561020_0_0_0"/>
    <dbReference type="OMA" id="HTQRHVG"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="18418" checksum="006DCFBBF92B8948" modified="2011-04-05" version="1">MPEPWLRGTLTEIDAVPRQILHALELAAEDCTRWCDDLTEPELNARPYGLPSVAFHMRHIARSLDRLLTYADDRWLDEDQLAALDTEHDPITREPLFQEFTLGLSEAAQRVRAFNPDRYDQKRSVGRNRLPSTLGGLLVHCAEHTQRHVGQMVTTAKLAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J2</accession>
    <name>E8X4J2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">AciX9_2365</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580718.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2365"/>
    <dbReference type="EnsemblBacteria" id="ADW69402">
        <property type="protein sequence ID" value="ADW69402"/>
        <property type="gene ID" value="AciX9_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2365"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_0"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="284" mass="31192" checksum="3822637E01E1EE6D" modified="2011-04-05" version="1">MFKAAIISKPQKPEVATLLPELIAWLNQHDYEALLDTDSAAYLNLPGKDRTLLPQDDPSLVIVLGGDGTLLSAARAFARTQTPILSVNLGSLGFLTEIPLSDLYQTLELWCNGYADIDLRVMMNARLLRDGKVRREWDALNDVVVAKGTIARMADYTVKIDDQLVATFRADGVIVSTPTGSTAYNLAANGPIVMPSVNCMLVTPICPHLLTIRPMVMPGEARITIQIEGVPNQIYLTVDGQEAIELEIGDEVQCCRSLSSVRLLRLHPNGLFNVLRSKLKWGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L8</accession>
    <name>E8X4L8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2391</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580744.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2391"/>
    <dbReference type="EnsemblBacteria" id="ADW69428">
        <property type="protein sequence ID" value="ADW69428"/>
        <property type="gene ID" value="AciX9_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2391"/>
    <dbReference type="eggNOG" id="ENOG50332WZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341684_0_0_0"/>
    <dbReference type="OrthoDB" id="1930970at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="22179" checksum="222D1BC0A9B26842" modified="2011-04-05" version="1">MIGFLVGAILGVFGQGAGPADSLITFQFDRPALRQPGYTFEVHRDGRAAYTQAGVSVPLEVSTGLAARIFEEAVSVARFDFPCASKKKGIADTGLKTLAYKGQDGAGSCTYNYTESKTVQTLTDQFQGMALMLEEGRKLEMEHKYDRLALYGEMTTLEGMVKDGRAIEVGLIAKELWSLVGDPDVLEKVRVKAGDLLKTMEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R9</accession>
    <name>E8X4R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581869.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70558">
        <property type="protein sequence ID" value="ADW70558"/>
        <property type="gene ID" value="AciX9_3554"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3554"/>
    <dbReference type="eggNOG" id="ENOG503363K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1895174_0_0_0"/>
    <dbReference type="OMA" id="PNVNNRD"/>
    <dbReference type="OrthoDB" id="2060206at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234373" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13624" checksum="3431BD166ED4A6A8" modified="2011-04-05" version="1">MNLKKLAAPALAIALLTTASAFAQGYGGPPPPPQGYGQGPGGPGGWEAPPPEFQAAQARGYHDGVEGARKDFENHRPPNVNNRDEYRHPGFIPGPERRDYKFGFRRGYDNAVRHMYGPGPGGPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T6</accession>
    <name>E8X4T6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3571</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70575">
        <property type="protein sequence ID" value="ADW70575"/>
        <property type="gene ID" value="AciX9_3571"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3571"/>
    <dbReference type="HOGENOM" id="CLU_3328449_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="38" mass="4310" checksum="1E4F9D74E90647B6" modified="2011-04-05" version="1">MTITPNLMRKLKQLLCVCAAALDLAGKGYDLYRRIMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V7</accession>
    <name>E8X4V7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_3593</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3593"/>
    <dbReference type="EnsemblBacteria" id="ADW70596">
        <property type="protein sequence ID" value="ADW70596"/>
        <property type="gene ID" value="AciX9_3593"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3593"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_0"/>
    <dbReference type="OMA" id="NIAGMQV"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="482"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="570" mass="59912" checksum="A9AED4A77B127A92" modified="2011-04-05" version="1">MVVPPSIYKSSTAKASTLKIVIAEKVSPATLAILQQESGWNCITADKIKDREALKAELADADALIVRSAVQADAELLESAPKLRVIGRAGVGVDNIDTAAATHRGIVVMNTPGANAVAVAELTLGLMISMGRSIPRANKTMHEGVWDKKSLQGSELRGKTLGIVGLGRIGLEVARRAAAFGMDLIAYDPFIAPVIAREHNVTLVSLDDIFKASDYLTLHVGLTTQTEGLINQHSIAIMKSGIRIINCARGELIVDEALVEGLKSGKVAGAALDVFHQEPLKNSPYFNLPNVLLSPHIAGATDEAQEAIGIQLAMQVRDYLKLGVVQNAVNLPSLSHEEYIEVAPYIEMAARLGRFLSHAIPGHLETISITYTGRIATGKTDLIRNAAVAGIFADTEGGNSVNRINAAAIAQERGIRIQEDKKEFVAGGSGSVLKLVLHSSGPGADSDAGCDTSASATVLHGTSPRLLTLDGIDIEAPLNGTLVSIRNHDVPGVVGRIGTILGEHKINIANFALGRASDTPGRSSQRVPQGQALAVVQIDVPDSHAAAPALAALKQIEAIVSVRLIELAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X2</accession>
    <name>E8X4X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transport protein SCO1/SenC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0073</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0073"/>
    <dbReference type="EnsemblBacteria" id="ADW67164">
        <property type="protein sequence ID" value="ADW67164"/>
        <property type="gene ID" value="AciX9_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0073"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058434_2_0_0"/>
    <dbReference type="OMA" id="YIFGFIR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230232" evidence="3">
        <location>
            <begin position="31"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="33267" checksum="9C876F398657C894" modified="2011-04-05" version="1">MPKSLTTRKSWWMGVLSAALLAGFSAGLSAQVSSYGDKETGQNTGDQLPQVLQKVAVTQHLNQALPAGAEFVDETGKTVHLSDYFGHRPALLSLVYFNCPMLCSEELDGMTSALEMVKLTPGKDFDVIIISIDPSDTPEAAAKKKAFYLKRYGRPETAAGWHFLTGQRPAIDAVTSATGFGYVRVPGPDGKLTQFAHASSLEVVTTDGKLAQYYLGVEYSPKDVLLGLIEASGNKIGSPVANILTYCYHYDPQTNKHSLIVARVVQFGGMVTMASLGGFMFLMFRRDLKLGREHDLTGSDTEKTDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y0</accession>
    <name>E8X4Y0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0081</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578501.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0081"/>
    <dbReference type="EnsemblBacteria" id="ADW67172">
        <property type="protein sequence ID" value="ADW67172"/>
        <property type="gene ID" value="AciX9_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0081"/>
    <dbReference type="eggNOG" id="ENOG502ZHB1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2329809_0_0_0"/>
    <dbReference type="OrthoDB" id="2214192at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="11350" checksum="E88C347582BEE899" modified="2011-04-05" version="1">MSDLLFAQLAHDHVNSERDDPVAPCGECGVSKERIRAKRLMTRDQVNKYLALSHEQVQSLINTRQITVIRLKGEVRFDSKELDILIETYKQTAQRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X591</accession>
    <name>E8X591_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1293</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1293"/>
    <dbReference type="EnsemblBacteria" id="ADW68355">
        <property type="protein sequence ID" value="ADW68355"/>
        <property type="gene ID" value="AciX9_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1293"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_1_1_0"/>
    <dbReference type="OMA" id="GVTICHG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234394" evidence="1">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="81"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="45202" checksum="AD5A287FA2E4DC9F" modified="2011-04-05" version="1">MGYAAFIMKILAGVLALAAVSALGQGKSDEPVMVLKAARMLDVRAGRVVSPGMVVVQGERITAIGGAAPAGAKVIDLGDVTLMPGLIDAHVHLFLHVGAEDLQTVEESVPERVLIAADAAKADVMAGFTAERDMGSEGAGCADVAVRNAINKGLIPGPRMRMSCNAIDLTGGHEDANRFNPAQHVLSNADYADSADEIVKVMRQQRKEGADFTKIYETGRDSYVGGVFTTPYQYSVEELKAAVAEAARFGTGAGHGVAVHATGEPGTGYAVEAGVESVDHADNLSAATMKMMKAKGIPAVPTFAISEYFAEQTTAPAAKARRQDANAFHVAEFRKQLAAGVPMAVGSDVGPFPHGTQARELELMVQNGMSAPDVLRADLLNGAKLLGWEGKIGELKAGYYADVIAVEGDPVKDISAVTKVKFVMKDGVVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A1</accession>
    <name>E8X5A1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1303</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579688.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1303"/>
    <dbReference type="EnsemblBacteria" id="ADW68365">
        <property type="protein sequence ID" value="ADW68365"/>
        <property type="gene ID" value="AciX9_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1303"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_1_0_0"/>
    <dbReference type="OMA" id="EADVQIY"/>
    <dbReference type="OrthoDB" id="806134at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="347" mass="38384" checksum="3040F117560691A7" modified="2011-04-05" version="1">MRDRERWKNGLGRMLGVLALALACGPLGRGQENPLDKVETSIPKPPAAKAPAAPEDKLPEATVARPRNGARLRLEANLVLVPMTVTTTDTNRLVTGLEATNFEVFDNNTGQVIKTFSTQDAPVTIGIVFDLSGSMTSKFGRARKALSEFLRTSNPADEFFVVGFNDKPAVIVDYTSDVEDVEARMVMLKPENRTALIDAVYLGVNKLKEAKYDRKALLIVSDGGDNRSRYTEGELRRVVRESDVQIYSIGIYDAYAPTEEEQLGPVLLKDISEMTGGRMFPVTDIADMADIASRISAELRNEYVIGYRPTEVKKDGNWRKLKVRLVPPPGLPAMDVHYRQGYYAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F0</accession>
    <name>E8X5F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma 54 interacting domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2464</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580813.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2464"/>
    <dbReference type="EnsemblBacteria" id="ADW69497">
        <property type="protein sequence ID" value="ADW69497"/>
        <property type="gene ID" value="AciX9_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2464"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="IGCLERA"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="141"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="468" mass="51809" checksum="04A9037FACA546FC" modified="2011-04-05" version="1">MEMRALLLDFAIHPGERLEPALLAQAGLAVEVRESVVAPFGDLAQPGVALVVVNMGADSQPTEELFQWLKCNALRAAVLGVLPPDGHEALQRAAGAVDDFLLAPVHPEELRQRVLRLIGVAAPECARPEYECARELALRNVEGGDPAFLSVLARLVDFARVGAPVLIGGETGTGKELCARAIHLLSARRNGPFIPVECGSLPDHLFESEIFGHTRGAFTDAHKDQKGLVALAHNGTLFLDEVDSLSLVVQGKLLRLLQESTFRPLGADKFSRADIRIIAASNVSLKQRVEEKRFRSDLFFRLDVLRLHLPALRNRPSDIPLLARKFTDEFCDEYKQHRKRICPASLRLLQSWHWPGNVRELRNTMQRAVLHATGHEVLPCHLGFDSGQDTVEWSGESLLERSCNSLTADFRSSRARAIAAFEADFVQRLLEKHQGNITRAAREAGKERRAFGRLAQKYVSPVSRVGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N0</accession>
    <name>E8X5N0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3654</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3654"/>
    <dbReference type="EnsemblBacteria" id="ADW70657">
        <property type="protein sequence ID" value="ADW70657"/>
        <property type="gene ID" value="AciX9_3654"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3654"/>
    <dbReference type="eggNOG" id="COG4655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046706_0_0_0"/>
    <dbReference type="OMA" id="QARSFCI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="528" mass="53155" checksum="E38D1396E2984331" modified="2011-04-05" version="1">MGLLPIVIGEGCCILRREVGGGAFAGPCLRALCAVSALLFASATWDMPEAFRDVRVCDLGDTSVFHEGGCTLLRIFRDEDGSATLIAAFGMVAILGFLALAVDVGQLRYQKRGLQKAADAAALASVLEMSYCDGTLACGVMQTAAKSAMVENGLTPDNIVTACGTVPSTGLTLMINHGPCAKGASDPNYGKTSSVEVLVMQAQPTIFAKVLGLSTGTVGARAEASTTGGTNCIFALDPTGSGALTVQGLASITSPCGIMVESSSNSALSCAVLGVITASAINVVGGVSNFLCAIAPVPKTSASVPKPADPLAYLAAPTMPGCGISTSSPYHGAGSTVTVGFGQSATFFADGAYCGGITVQSGGTAVFQPGVYALTSNNGGATKLPGGLTIDLGTNVSGTGVTFYNYGPSGGITFLAPSLSLAGVRLVAPTSGSYAGILFFQPSNNTNGATLLGSTVYNTILEGAYYFPKAKVTFCFSGPVNYNILVAYDIVFEALTFGFTTVTSSFANNYGSLATGSPLAGNGAVISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q5</accession>
    <name>E8X5Q5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative periplasmic ligand-binding sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3681</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581991.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3681"/>
    <dbReference type="EnsemblBacteria" id="ADW70682">
        <property type="protein sequence ID" value="ADW70682"/>
        <property type="gene ID" value="AciX9_3681"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3681"/>
    <dbReference type="eggNOG" id="COG3416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899449_0_0_0"/>
    <dbReference type="OMA" id="MAQAMII"/>
    <dbReference type="OrthoDB" id="1945796at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018648">
        <property type="entry name" value="DUF2076"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09849">
        <property type="entry name" value="DUF2076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="31448" checksum="76D8496279A95ECE" modified="2011-04-05" version="1">MTPQEQQMIQGLIDRVQKTQLPEKDAEAEQLLQQGLGRNPDALYIMAQSLLVQGYALEQAQKQLPDLKAQLADATAQLNELQQQQNQYQQQAPPPPQQKHTSFLGNIFGAGDDRPAPPPAYPQQGYPQQGYPQQQPQYAPVANYGQPAAYPPPSYGGPQYGQPAPPQGGGFLRGAMQTAAGVAAGAVAFEGIESLMHGFGHSGGSEGFGGFGGGGGQREEVINNYYGDDAGRGHDGHGLSSDIEDRRDDTRFGDTGDNSGNDNSKDFADTDDSNDDSSSFDDSSSDDSGSDDSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R5</accession>
    <name>E8X5R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4003</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572711.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70799">
        <property type="protein sequence ID" value="ADW70799"/>
        <property type="gene ID" value="AciX9_4003"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4003"/>
    <dbReference type="HOGENOM" id="CLU_112762_0_3_0"/>
    <dbReference type="OMA" id="LSWSWNV"/>
    <dbReference type="OrthoDB" id="1153621at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="16444" checksum="EA2D14B7408D29DF" modified="2011-04-05" version="1">MAVDFFFKLADIPGESVDSKHPNEISVMSFSWGASQTTSVSGSGGSGAGKASLADLSIMKNYDVASGPMYKALLLGTHIATGVLTAVKSGGDGSPFLTISLGEVFITSVQVSGSSEVPMESVSFSYNTISTEYAQQDETGKLNVKAAINYNLKQNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V5</accession>
    <name>E8X5V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4044</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572751.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70839">
        <property type="protein sequence ID" value="ADW70839"/>
        <property type="gene ID" value="AciX9_4044"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4044"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="24086" checksum="A1CAE5621FCFEA32" modified="2011-04-05" version="1">MADPILEVCNLHKNYDQGRIEALRGIDLSIDAGEFVAISGHSGSGKSTLLHLLGGLDTPTSGEVQFRGAILGSSISLDKYRCHHVGFIFQSFYLLPTLRAIENVQAPMLATGDGGSDREKRAEALLREVGLESRMRQYPNELSGGERQRVAIARALANNPSILLADEPTGNLDSKNSARIMEILTGLQKTRGMTLIVITHEPEIANSAPRHIRIHDGRIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W3</accession>
    <name>E8X5W3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inositol oxygenase</fullName>
            <ecNumber evidence="6">1.13.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4058</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572759.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70847">
        <property type="protein sequence ID" value="ADW70847"/>
        <property type="gene ID" value="AciX9_4058"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4058"/>
    <dbReference type="HOGENOM" id="CLU_050259_1_0_0"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="687466at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="PTHR12588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="33451" checksum="8F8142728B7F332E" modified="2011-04-05" version="1">MSTAPVIPTGPLHDLDDWDDFLEGRYKEGKSESEFRQYDATATPGVAEFYRLNHENQTVDYVLEKEKAYFSLKKGQKTIWEAAEFLNTLVDDSDPDTDLTQIEHLLQTSEAIRRDGHPRWMVLTGFIHDLGKCLCLYGEPQWGVVGDTFPVGCAWSKDIVFPEYFANNPDRHNTLYQSKYGIYEPKCGLENLHMSFGHDGYIGEVMKNYLRDESLYMLRFHSFYPWHRHGAYDHLCNDKDRAMLEWVLKFNQYDLYSKGHTKPNIVELKPYYDDLFAEFLPPTLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X4</accession>
    <name>E8X5X4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4075</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70858">
        <property type="protein sequence ID" value="ADW70858"/>
        <property type="gene ID" value="AciX9_4075"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4075"/>
    <dbReference type="HOGENOM" id="CLU_006501_0_1_0"/>
    <dbReference type="OMA" id="GNEVDYP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="45"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="213"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="322"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="630"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="8">
        <location>
            <begin position="695"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="812" mass="88441" checksum="240CB9AAC1FEAFBF" modified="2011-04-05" version="1">MPHSLTRSVSRRLAWAAIVLVSALSAQGQRRVSAGVSCGRQEVLLDTDWRFHLGDAAGSEQPSASDSVDWQPVTLPHDWAIHGPRLVTNLSGGAGGFAPMGIGWYRRHIPSPTTACAGRALVQFDGIMANSDVWLNGHLLGHRPNGYVSLVYDLTPFLNATPGADNLLLVKADNSQQPASRFYQGAGIYRHVHLIHVPELHLETWGTAIATPHIMPVSAEVSVSAEVRNDASQSRTATVRVTILDASGHRVAQASSIAQAVAAGAVHSFAVTLNVSHPRLWDVKDPNLYQAKVEVLQTGQPGDLQVSTFGIRDAHFDAATGFSLNGRTVKIKGVALHSDIGALGMAVPLSLWEHRLRAMQHMGANAIRTAHNPVAPEFLDLCDRMGFLVLDEFFDVWTVGKNPYDYHLNFRDWYLRDTRDSVRRDRNHPSIIAWSAGNEIHDTPHPDVAKPILASLIAEYHKDDPTRPVTQALFRPNASHDYEDGLADMLDVIGQNYRPGELLAAHEARPERKILGTENIHDRATWLAVRDNAAYAGMFLWSGTDYLGESRHWPLFADQSGMNDRTDFPKPDSLERESWWADRPVVHIVRRTARVPKAPTDPGYELDQYRPQQVTFPDWTPANREPHPEQVEVYSNCREVALSLNGQSLGAKTLPPDASARGWQVTFEAGLLKARCTDQPGVEETLTTAGTPAGLSLTAESKQLGTTFDDVTEVRLTVVDAHGTPVPGVAVPVTFSVAGDGTLLATDDADPTYTAAFENPTRTTLDGRAVAFIRGNGGGTLTLQATSPGLAATNLRFMPPNASAALALKGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y0</accession>
    <name>E8X5Y0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572776.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70864">
        <property type="protein sequence ID" value="ADW70864"/>
        <property type="gene ID" value="AciX9_4081"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4081"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NCCVANT"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233722" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1100" mass="118039" checksum="2759B403BB71AEC4" modified="2011-04-05" version="1">MIRIKRHQLCALGTLAFAAAASGQNTTQGAISGTVFDPSEAAIPNATVRIHNDGTNADLTLTTNDSGFFKAPALAPGTYTVTVEATGFGTLRTNQVTVEVNLVTEVSPHLQTGSAGGQTVEVTADAPVLKFDSPAYGGQLTNAEIENIPINNRRWSSLSLLTPGVTNDAQGFGLISFRAIQPQLNNVQIDGADDNQVFYGEERGRTRAGYSTSQVAIREFQINTGVYSAEFGRAVGGVINSVTKSGTNQFHGELYFYHRDQQWSASNQFTTTIAYDPVAGTASKIFFKPKDKRNQWGFGLGGPIIKDKLFFFYAYDQFQRVFPGTGSAASASFYTALTPAQSATLATSIQNGTGKPTTAAQASTAYNNLIAAANTDLGTTPRIGFQIINTPKLDYTINSKNTVSLLYHRLRWDSPGGVQTQSNVFYGKEGFAKDFVKLDYTVAKLDSVITPRITNEIRYQYGRELNDESALPNGSFVNQYMTANGNTPQVNLNNGSQGFIAGQPYYAFRPALPDERKWQIGDTALAQFGPHAVKFGTDIVHNYDLQNTLGFSGFSPNGTYNYTSVLAFAQDALSGDGGGCGTTPAAGVAYAPVGCYSYFHQTVGGTTFDMSTVDYGFFVQDDWKVSPRLTVNVGARYDYESIPGQQANLVVASFAPSANTISDKNNISPRVGFAYDPFGLGKTVIRGGFGMYYGRIPNVNILGARFASGAAAGQLSYNIPAPTAAGAPLLPTLPANFTGQTPDIQYIDKHLQNPYTEQFDLAVQQNLGWDTIFSLSYLGALGRELPNSLNLNVDPANAYTVNYTVLAGTTGTCGPLACGSVVPVKVYGQRRAGSSASVNLNPAYGAVYAGLSNVNANYHAATVGMTKRANKFMSFDVNYTWSHALDYNQTSVTGFSSNNFFDPYGNARANYGNSYLNVRHRAVGWAIFNLPGTKGHHYVDAATNGWSIKPALQVQSGLPYSASVNTANAPAQCTANGCLQATNGGLSGLGVTYVPAIGRNTYTYPRDLVIDVRIQKDFKLTERFNLQFIGEAFNVANYQNVTSLVTTAYNVTSTTNATTGSGTLTYQPHTATGGFGYVNSVNSNFAYSPRNIQAGARLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z4</accession>
    <name>E8X5Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572790.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70878">
        <property type="protein sequence ID" value="ADW70878"/>
        <property type="gene ID" value="AciX9_4098"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4098"/>
    <dbReference type="HOGENOM" id="CLU_058050_1_0_0"/>
    <dbReference type="OMA" id="NQSEWWR"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="327" mass="35039" checksum="940353507579D7BC" modified="2011-04-05" version="1">MEAFKFTRANDVPQAVQLGQAQGTRFVAGGTTLLDLMKLDVERPTRVVDINRLPLDKVETLPDGRLRVGALVRNSDLAHHPLVVEHCPVLSQALLAGASAQLRNMATTGGNLLQRTRCAYFRNDAMPCNKREPGSGCSAIEGDNRTLAILGTSKHCIATNPSDMNVALTALEAVIHIQGPKGERDIPIADFFLVPGTTPERETVLTPGDLITHITLPAPRKGAKQVYLKLRDRASYEFALASAAIVIESTGGRITFARVAMGGVGTKPWRSLEAEKALHGQPASEAVFHRAAEAALHAAQPQSQNGFKIELARRCVAHALTLATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X609</accession>
    <name>E8X609_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4113</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70893">
        <property type="protein sequence ID" value="ADW70893"/>
        <property type="gene ID" value="AciX9_4113"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4113"/>
    <dbReference type="HOGENOM" id="CLU_079895_0_0_0"/>
    <dbReference type="OMA" id="ANLIWLN"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="107"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="267" mass="28799" checksum="9DAC9B92FA6EB8F6" modified="2011-04-05" version="1">MGKRQIDKSTVVGVMLAGAGVVAGLLLDGGTVRQILQPTAALIVVGGTLGAVMIQFPMQTIRSTIKELRHALLDAKPLNRELVEELVSWCLQARRMGMLALDAYLPQIADPFFRKGMMLAVDGVGVRELRDTLEVDLDVWHEREAGVAKVLEAAGGFAPTLGIIGAVLGLIQVMQRMDNVGEIGKGIAVAFVSTLYGIGLANLVFLPLAGKLKIRMRERQLVREMTLEAVVSIMEGVSARALRQRLEAYLTEGPSEAQGRAEPEMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X624</accession>
    <name>E8X624_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572820.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70908">
        <property type="protein sequence ID" value="ADW70908"/>
        <property type="gene ID" value="AciX9_4128"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4128"/>
    <dbReference type="HOGENOM" id="CLU_1213425_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25413" checksum="1FC15BB8385C5DD1" modified="2011-04-05" version="1">MQEDQYAVVETSLYISDILSSSSPNRLLDSLPNIPTMMTTRLRLELLLQEPSIDLSAVSEVILSDPGATLQLLRLIGEEYPNDEDRPTRIEDCIVSFNSNRWYEVVCALSIPQSSHVLAHWEYWRRVAQCARELAKCVDGLSPEEAYLVGLLSQLGTLPHILGWNNDTGSSAEHSAVGVMLADYWHLPTYFCCAIQELQSPASSSRWGEILQMAQAVAIKSEPAAFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X657</accession>
    <name>E8X657_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glucose/galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_4161</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="14 15">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
            <plasmid evidence="15">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intake of glucose and galactose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572853.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70941">
        <property type="protein sequence ID" value="ADW70941"/>
        <property type="gene ID" value="AciX9_4161"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4161"/>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_0"/>
    <dbReference type="OMA" id="PVIREHS"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005354">
        <property type="term" value="F:galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005964">
        <property type="entry name" value="Glc/Gal_transptr_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01272">
        <property type="entry name" value="gluP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0614">Plasmid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="13">
        <location>
            <begin position="23"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="440" mass="46568" checksum="468BF5D18B0305A0" modified="2011-04-05" version="1">MAMTTNVSAPGIGSERTKTDLRAMSIATALFFLWGFLTSLNDILIPHLKGIFELSYAQALLVQFAFFSAYFVFALPSGKLVDWRGYKQTMVIGLVVMACGALLFLPASTAASFALFLTALVVLAAGITCLQVSANPYVTSLGPENTAASRLNFSQAFNSLGTFLAPLAGGALILGGTQMAPDKLHSLAAAARQAYRAEQASSVRLPYLGIALALLALAAALGLLKLPSASTNEYTQDFRPGELNEDKGSIWGHKWLLLGAMGIFVYVGAEVSIGSFLVNYFGLPQIMSMSEQTAAKYVSLYWLGAMIGRFIGSALLQKLRTGMVLGSAAMMACLLVLVSMATHGPTAMWAIISVGLFNSVMFPSIFTLGLANLGALTSKGSSLMVCAIVGGALLPLFEGFLADRVGVQHAFIVPVLCYVFIAFFGFSARNLMTSTEKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X662</accession>
    <name>E8X662_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4166</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572858.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70946">
        <property type="protein sequence ID" value="ADW70946"/>
        <property type="gene ID" value="AciX9_4166"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4166"/>
    <dbReference type="HOGENOM" id="CLU_066842_1_0_0"/>
    <dbReference type="OMA" id="CQDAHHW"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="34248" checksum="8BAC6B810C6D4825" modified="2011-04-05" version="1">MQTWRVLAASITGSSHQQSGLLCQDAQAEATLPNAITLLAVADGAGSALRAREGSTTAVRAAIHHLTTQLTTIPQTEAAWRTLLTQTLTHARKSLQTLAKTKPLRDLATTLLVAILTPDHIALIQLGDGAIVSRSPTGDLHVLSHPRLSEYINETDFLTGDNYLQAAVLTILPASGIAALALFTDGVEVLALHHATNTAHPAFFHPLFDYVAAPEATHNQAVQELEAILTSARVNALTDDDKTLILAVREPAASEPATPEPPASEPATPIAAPQKPTPQPAPTATPTPAPEPLSSSWNKPSPAAQQFTKKKSKQSTKSRKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X684</accession>
    <name>E8X684_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4189</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70968">
        <property type="protein sequence ID" value="ADW70968"/>
        <property type="gene ID" value="AciX9_4189"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4189"/>
    <dbReference type="HOGENOM" id="CLU_027430_0_0_0"/>
    <dbReference type="OMA" id="YTNVWQN"/>
    <dbReference type="OrthoDB" id="129308at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5597" evidence="4">
        <location>
            <begin position="414"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="566" mass="61711" checksum="69E8C148EA477BC5" modified="2011-04-05" version="1">MRNRFQTRGEQGIVHLDSGEEKPVRVMKTVVAAALGMGLIFGSTAGGQELPRVEMRDGRASLFVDGRPYWVLGAQVDNSSGWPERLEALWPATERMRLNTLEVPVYWEQMEPARGKFEFGVVDALMAQARAHHVRLVMLWFGTWKNGRSHYVPGWVKADTVAYPRMKTREGKAIDVLSPNAPANLAADQAAFTALMRHLKETDQQHTVVMMQVENESGSLGSVRDFGADGAREFAGAVPSELVRGLGKRPGTWAQVFGEDADETFAAWSVGRYIEQVAAAGKAELGLPMYVNNWLKSPRGYPVETVPGEDYPSGGPTVNMHGVWKIAAPSLALLAPDVYVPNSEQYRGVMEAFHTRGNALFIPESLGFEPFPGASGYGRYLYYALGEGAIGFANFGLERVRLEGMDAETSAQIEGFRLLGGFDRELAKLAFEGKVRTAVEENGIAQKEIVLGSGLSAVRVVVSFPPAYDPPASPVSVSSDTTQLHEGRVVVGELGGGEFLVAGIDCRVMFEAPVHSKTQVQMLTVEEGRYDGETWVPGRLWNGDETDYGLNFGGKGSLLKVKIGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X690</accession>
    <name>E8X690_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4195</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572886.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70974">
        <property type="protein sequence ID" value="ADW70974"/>
        <property type="gene ID" value="AciX9_4195"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4195"/>
    <dbReference type="HOGENOM" id="CLU_1413392_0_0_0"/>
    <dbReference type="OMA" id="MEATHHS"/>
    <dbReference type="OrthoDB" id="2139941at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="22197" checksum="BC174008C5CDFFF7" modified="2011-04-05" version="1">MPRPISWLPRLHQIRKTVDSSVRSHYERKDIETLFELQPRAAQLLLEMLPTTLIGRSRLVARESLAAFLEQMRVSDDPSAKLEDIRKDPPPPPRSRLRTLIQRDRHPISLAELPPEINLTTGRLEIRFTTIEQLARHLYSLAQSMESDGDEMARRFEIKPLTPPNLADDDSRALFLELEAMEATHHSSRRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E0</accession>
    <name>E8X6E0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572936.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71024">
        <property type="protein sequence ID" value="ADW71024"/>
        <property type="gene ID" value="AciX9_4248"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4248"/>
    <dbReference type="HOGENOM" id="CLU_153062_2_1_0"/>
    <dbReference type="OMA" id="PRAPFCG"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="8433" checksum="7E421D0EA59AF619" modified="2011-04-05" version="1">MPDLCITINGIEVRVVKGTTVAAAMLQVGVACRISVSGEARTALCGMGICFECRATVDGVPHRTTCQLQCVEGMTAETMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V6</accession>
    <name>E8X6V6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3982</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71256">
        <property type="protein sequence ID" value="ADW71256"/>
        <property type="gene ID" value="AciX9_3982"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3982"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="IMQRYPS"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="38805" checksum="0A667D06A1C7DFD2" modified="2011-04-05" version="1">MPKKTAVNLAGGRRVGLKMLAEYLDLSPATVSFVLNNAPGRSIPPATRERVKAAAKKFGYQPSLIARSLQGLTTRTIGILIPELGEGYHSQVLSGAADLLMQEGYFFFTAHHRHKKDLVAEYPQLLRSRGIDGILAIDTHLEAELPAPAVCVAGHTVIPGLTNVVLDHHRAAELALGHLYRLGHRKIAYMHGQPFSSDSKTRWNATLQVARALSLRVSPDLVIRLDKDMSSPELGYPGIHQLLLRRKDFTAVLCFNDVSAIGSIRALHDAGLRVPHDVSVLGFDDIQAAAYVVPSLTTIRQPLHQMGSMAASLLLKKLAHEKIPDVVKLDPELVVRESTAAVRAVVRAARGTGKAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X730</accession>
    <name>E8X730_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3856</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71139">
        <property type="protein sequence ID" value="ADW71139"/>
        <property type="gene ID" value="AciX9_3856"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3856"/>
    <dbReference type="HOGENOM" id="CLU_061778_1_0_0"/>
    <dbReference type="OMA" id="VFMTQDA"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="37546" checksum="8306D48526F860FA" modified="2011-04-05" version="1">MGSMAYGSSDLPLIKRDWSKVGVVVPTFNAAPLWEALRSRLDLQGLPPEQILIIDSSSTDGTISLAKAAGYRCISITKSDFNHGRTRQLGCDHFDWADILIYITQDALPADATSFSTLCSVFVDPKVGAACGRQLPRPGANAIERHARLFNYPETSTQRNLSSRAYLGIKAAFLSNSFAAYRRSALLQAGGFPSNVIMAEDSVVAARLLMGGWEVAYIAEAAVIHSHSLSIWQEFSRYFDTGVHHACEPWIRETFGGAGNEGKRFVISELFYLRTHQVGLIPSALIRTFSKLFAFQLGLREKYFPVVIKRSLSLQPSFWTTLKPECLPQLRDKEVRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X740</accession>
    <name>E8X740_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4318</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71274">
        <property type="protein sequence ID" value="ADW71274"/>
        <property type="gene ID" value="AciX9_4318"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4318"/>
    <dbReference type="HOGENOM" id="CLU_1076729_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234269" evidence="2">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="26612" checksum="FA64FDC57ED80A7D" modified="2011-04-05" version="1">MPMTYRQKRPSLSLAMVFSLVLATVTPFKSSAQIVVTIGPPQIRIDAQPPSPGEAFVWAPGHWGRNASGYAWIQGSWLMPPSAGMLWTPGYWRPQPGGFAWQAGRWGTSVGYYGGVNYGFGYLGSGFTASALRHDEIRHEVQQYREESGVRSNAGGRPSYPSSDHGNGWSPNGQSSQAGHGSATYGGGRPNPSNISGNGNAGGGTGPSGSEGSSSPTSGVHAGAGAANPSGPQPTGERVPKSGTGTGYGNPGGSYSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X756</accession>
    <name>E8X756_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4338</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573009.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71290">
        <property type="protein sequence ID" value="ADW71290"/>
        <property type="gene ID" value="AciX9_4338"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4338"/>
    <dbReference type="HOGENOM" id="CLU_077149_3_1_0"/>
    <dbReference type="OMA" id="QMTSFDL"/>
    <dbReference type="OrthoDB" id="1884218at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16613" checksum="950FC4146000E462" modified="2011-04-05" version="1">MAAVLRAFFFYIFLVFIVRVVGRRPGKQITPFEFVLVFFMGGLALTAMVGDDASLTNALLQIITIAFAHYWVAFLRSRSNRLARLFDGTPLILLEDGLWRAETLSKMGIQDDDVMATARDQGILTLDQIDLAILERNGEISIVKKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X767</accession>
    <name>E8X767_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4349</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573020.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71301">
        <property type="protein sequence ID" value="ADW71301"/>
        <property type="gene ID" value="AciX9_4349"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4349"/>
    <dbReference type="HOGENOM" id="CLU_2246178_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="11526" checksum="D47926FEDD84D8A0" modified="2011-04-05" version="1">MNPREITPLLLDKRHKTDFLEQFDRSLRLAEEDVAAVAKDGAIEGNLTAIVAKYAADQSATYEPGLINLKVFASDGAAGDRSHDELLKGWMNHFLRTCRACGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C8</accession>
    <name>E8X7C8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicupin, oxalate decarboxylase family</fullName>
            <ecNumber evidence="5">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4412</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573081.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71362">
        <property type="protein sequence ID" value="ADW71362"/>
        <property type="gene ID" value="AciX9_4412"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4412"/>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_0"/>
    <dbReference type="OMA" id="EWGFFLE"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="61"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="233"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="42757" checksum="B67736FE188C6B4A" modified="2011-04-05" version="1">MATLVETTPNGFAQPIRGTEGAPIIGPSNHEREAQSPGRLTPPVTDHGTLPNLKWTFADSHNKLEEGGWARQTTVREMPVAVELACVNMRLEAGVVREMHWHKPAEWGFMIKGNARVTCVDEEGKTYQADCTEGDIWNFPSGIPHSIQGLSGEGCEFLLVFDDGAFNEEETFLVTDFLAHIPKSVLAKNFGVQESAFANIPKSEKYIFRADIPGPLAQDRVVGAGPTPVIYTHRMGAQEPIKSNNGSVRVTDSTNFPAASTVAAALVEVEPGGMRELHWHRTSDELQYYLEGQGRMTVYTSNTNAGTFDYQAGDVGYVPCVTPHYVENTGTTTLRYLEVWKTERFSDMSLAQWLAFTPYELVRAHLQIEKSVLDRVSTTKTPIVGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D3</accession>
    <name>E8X7D3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">67 kDa myosin-cross-reactive antigen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4417</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573086.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71367">
        <property type="protein sequence ID" value="ADW71367"/>
        <property type="gene ID" value="AciX9_4417"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4417"/>
    <dbReference type="HOGENOM" id="CLU_024043_2_0_0"/>
    <dbReference type="OMA" id="CRLIHKR"/>
    <dbReference type="OrthoDB" id="123225at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="543" mass="60401" checksum="96984FF315F8AB9C" modified="2011-04-05" version="1">MTQRRALQEDTKIYVIGGGIASLAAAAFLIRDAGLKGHNIIILEDSERIGGSLDANGTPEAGYVMRGGRMIESKYLCTFDLFSSIPTMDNSQSVTEEIFAWNKTMKTSSKSRLFRNGKSVDAPLFGLSESHILTIERLGVEPESLLGRTTISDQFEPDFFETDFWFMWCTTFAFQPWHSAVEFKRYLVRFTHMVSGFSTLGGIMRTVYNQYDSLVRPLQRWLEERGVQVSLNTKVLDLVTVNDSHGFAVEQIVCERGGHPEPIHLSPSDFVIATLGSMTEGSSFGGMDQAATLNPRADGGAWSLWKKISAREPECGKPTNFSNNTENSKWLSFTTTLRSPNFFTSIRDLTGNAPGEGGLITFPESNWLTSIVLPHQPHFLGQPDDVNVFWGYGLFVDQPGNFVKKPMAECTGREIMTEIMGHLHLGEQAAAVLSKSTCIPCMMPFITSQFLPRSAGDRPAVLPERSKNLAFIGQFCELEDDVVFTVEYSVRSAQTAVYGLLGIDRKPHPVYKGNHDPRVLLKAFLTLHGKRDREALLEPPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E8</accession>
    <name>E8X7E8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4435</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573101.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71382">
        <property type="protein sequence ID" value="ADW71382"/>
        <property type="gene ID" value="AciX9_4435"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4435"/>
    <dbReference type="HOGENOM" id="CLU_078758_2_3_0"/>
    <dbReference type="OMA" id="YETRTEW"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="123" mass="14207" checksum="D093F88147B9C2F4" modified="2011-04-05" version="1">MFNKVILIGRLGQNAEAKTAQNNKDYVVLNIATQESWKNDKGDYENRTEWHRVYAWRNLSKFARTLQKGQLITLEGVLRYREVVEDVEGAKFKHRIAEIHAISMKRLSKVEADDDPSDGADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G2</accession>
    <name>E8X7G2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71396">
        <property type="protein sequence ID" value="ADW71396"/>
        <property type="gene ID" value="AciX9_4450"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4450"/>
    <dbReference type="HOGENOM" id="CLU_2990345_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="57" mass="6027" checksum="0E53C57D643C0B6A" modified="2011-04-05" version="1">MPIVLLTIFLKGPAWLKACVLLALAGLVVVGGIVASTAIRNATERTGNHHAHPTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K9</accession>
    <name>E8X7K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4499</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4499"/>
    <dbReference type="EnsemblBacteria" id="ADW71443">
        <property type="protein sequence ID" value="ADW71443"/>
        <property type="gene ID" value="AciX9_4499"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4499"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_0"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="95"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="201"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="351"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="417" mass="44894" checksum="2E1C60A0279FEEEE" modified="2011-04-05" version="1">MVAEVLTTAGIPVALASIITPTPALSYAVRERGAAGGVMITSSHNPAQWNGVKYKASYGGSGKPSIISAIETYLGKPLAAAAEPSKLEEVNFNPPYVEAIAKFVDLPAIKASGKRFLIDCMYGAGRGIISGIFAEAGVPYVEMRAEINPDFPGINPEPILPHIAETQKRVVADACDAGLVTDGDADRIGAVDEHGNVVDAHKIFAILLQWLLERKGWPGDVTRAFNTTKMLDRIAAKHGRKLHEHGIGFKYVCDLMLTENILIGGEESGGVGISRHLPERDGLLNSLLLCQVMADEGKTLGELVAALQAEYGEHQYNRIDMHINDELKQSAIKRASAIKAGDDFAGMKVNRVETLDGIKFYLENSHCTDKVNAAETWLLLRASGTEPLLRVYCESCSVESVDAVLKVAESFVLEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U5</accession>
    <name>E8X7U5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71529">
        <property type="protein sequence ID" value="ADW71529"/>
        <property type="gene ID" value="AciX9_4599"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4599"/>
    <dbReference type="HOGENOM" id="CLU_2206323_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="12360" checksum="7C0217D07A892260" modified="2011-04-05" version="1">MREAVGHLKEEARFQTWTVFALILALGFALGAFGTYFFFTRQVSALNSRFDHFEQLLAAPHLLQRTPTSQRRRPGRSMGSTKGRLRGIMSNWRVMCFSIPFHARRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z9</accession>
    <name>E8X7Z9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4653</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573302.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71583">
        <property type="protein sequence ID" value="ADW71583"/>
        <property type="gene ID" value="AciX9_4653"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4653"/>
    <dbReference type="HOGENOM" id="CLU_004585_5_10_0"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="574" mass="64134" checksum="245D5568CD479AAB" modified="2011-04-05" version="1">MNEPSLEQKAIILEKLRPLCVIACAGSGKTFTAVRRMDTICSFLPQRRDNVALLSFSNVAVDLFGKTYRDDIVTMKRTRSSQVCIETFDGFLTSKILRPHANRVMKCASLPFLLSGTESFLSNPRYQFRPKGQQFPIKVDTVEAFLHDGRTVFFGRYQKAQVELERALQTVEALGALGAYTHNLGRYWAYRVLREEPRILKALARKFSQIVIDEAQDVGSSHIAIVELLAEAGSQVTLIGDPNQAIYEFCGADGNYLKRYALRKGVLKKELTINRRSVPRIVAVANSLSKRDDSAFRSTPASHNGAYFVRYDKGEESQVIEAFEKAVLAAGLDLSRSAIVCRANERKKRLRNFGSEVGQGVTKQFAAAAMARDSAGDYQQAFRLTARAVVMLLKSPPDHLCSRMLDVSRYPEYRSLRRIVWGFTRQPESGLPSATLKTASEWHPALLVRVKALLQKLNKEYGFSEMPNIGMKLAKKQLPDLPMVQTNQQKIIVDARLRVETVHGVKGESLDAVLYMAERAHLKALLDGTGSETGRIGYVAVTRARDLFWLGILTADATLHQKELVAHSFIEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV87</accession>
    <name>E8WV87_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0188</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578590.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0188"/>
    <dbReference type="EnsemblBacteria" id="ADW67262">
        <property type="protein sequence ID" value="ADW67262"/>
        <property type="gene ID" value="AciX9_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0188"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="GANECHV"/>
    <dbReference type="OrthoDB" id="1281138at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230338" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1412"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1445"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="243"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1502" mass="150163" checksum="5DD530ACE3F71C69" modified="2011-04-05" version="1">MSLFRSLFTGLGLGTALLGSAFAATNPHLTVQPQTRVVSKIDNADLARLPNTTPSIVSLAADNGRLPAATPFSHMLLVLKSSDEQELALRSLVDQQQDKSSPNYHQWMTPVTFGASFGVAASDLAKVTAWLQDQGFSIDAVSPGKRTIQFSGTSGQVETAFHTEMHRLTVNGVAHISNTVDLSVPTALSPVLAGIASLNDFRAKAHAVNPHPMVKGSDGQFYPIVPGTVATPDYTSTSSGSHYVAPADVATIYNAKPLLSGGTDGTGVTIGIIGQTTINLSNVETFRSMFRLPDNDPTIINVGPAPAIIADDIESDLDVEWAGAMATGAKVNFYTAAGGLVDGGVDTSALAAVDSNVADIISLSYGGCELSNGSAGTAYWNSLWEQAAAQGQTAFVSSGDSSATGCASSSAALANTATSGTYGVNALGSSAYNVAVGGSEFNEGTALGVTSYWGVGGTAPYGTAQSYIPETVWSEGVFDIVAPGTGIAGGGGGVSIFTGRPSWQVGPGITAADPAGPTFTATGAIPATQLHRLVPDLSLIAAGGHDGTIFCSEGVCKLDSSGNVASIGVVGGTSVATPVMAGVQALINQKNGGRQGNANYYYYKLAAAQTTANCASTLPPAATCNFNDIVTGDNFSPKTSVAKYNASTGTISGVLGTDYIGFTANTGYDEATGLGTPNITNLANNWKTVTFTATTTKLTLTPLTANHGTTQTAVITVAPTSATGTPTGDVSITAVGQAPGTGNGNVYTLSGGTVTAALTTLPGGTYSVTAHYAGDSVFGSSDSAPVTVTVAPEASQIFYQPYNLTTAGALNVATSFAYGTSIFIDTEVQGTSINGYTKNSVPNTGAPTGTILYNVSSGTTTLPSYTSSLDAYGITYLEAAQSFPNFLITANYPVLAPGAYTIKATYSGDQSFNTSNVSTAITVVKATVAPVVRAGTAEVLPAQTALLNVTIAASGGGVLPTGSVTLTDTVVSGTTTTSTTLGTVTLANGAAVLSTNALILPGAHSITAAYGGDANYAAASSAAVTVTVGGALSATTLAATVGGSAAATAPVLTSVVLTATPPATATGTVYFYDGSLVLGSATISTTTHLATLTIATLTAGTHSITATYAGNGTLAASTSLPMTFVTTQNKPTLSLTSQQANNAQSMASMNAVLTLVPAITSTAGANPAPSATVQFLDGTTVLGTAPLTYTLNYHFYTAASTFGPFKPGPHALTAVFPGDTNYAAATSGIQNISIGLTTITVTPSATNVGTGTPLTLTAKITPIVASSTAVGGSVTFFDGTTAIGTAPVTGGVATLTTATLSTVATHTITAVYSGDANFYTSTTSAGVNIVAVTPGFTISVNPASLTVKRGTPGTVTLTATSFGNYNGAIALSCQNLPLDTFCSFVNDSSGAPGIAFGGVNASQTVAITFSTLAPSNSGLLWLPAILLAGLLGLTRKRLSVRGRQFITLVVIACGMTAASGCGGGTITATPTGTSTVTIVANGAGAGSSPSLQPTATVALTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD7</accession>
    <name>E8WVD7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1323</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579708.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1323"/>
    <dbReference type="EnsemblBacteria" id="ADW68385">
        <property type="protein sequence ID" value="ADW68385"/>
        <property type="gene ID" value="AciX9_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1323"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_0"/>
    <dbReference type="OMA" id="VHPGNMV"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="34146" checksum="A0A19F55E32452A0" modified="2011-04-05" version="1">MAVQFGAKSTTDEVLAGVDLKGKRILVTGVSAGLGIETARALAAHGADVVGAARDLDKAKRATTEVSKAAAEAGGSLELIELDLADLKSVRAAADKLVADGRPFDVVIANAGVMATPEGKTADGFETQFGTNHLGHFVFVNRIAGLIREGGRLVNLSSSGHRFGDVDLNDLNFETTAYDAFLAYGRSKTANILFAVEFDRRHREHGVRAAAVHPGGIHTELARHMPDGAIAAFIDQLQEQRAAEGEPPFEFKTIPEGAATSVWAGVVAAADEVGGRYCEDCHVGVVLPADRQVSAISTGVRGYALDPATAKALWTKSEGLVGETFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE8</accession>
    <name>E8WVE8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1336</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68396">
        <property type="protein sequence ID" value="ADW68396"/>
        <property type="gene ID" value="AciX9_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1336"/>
    <dbReference type="HOGENOM" id="CLU_2180130_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="11161" checksum="6B9AE20819CB9C90" modified="2011-04-05" version="1">MALILLRVCLAGSLLCALLSRGGVPVSPGLWVVGGVLGLGVLAGAMLPLCCIAVLGLQLLLARITGWPGLMPVLVDMLQALALAFLGAGAFSVDALLYGRRVVILRNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF4</accession>
    <name>E8WVF4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579725.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1342"/>
    <dbReference type="EnsemblBacteria" id="ADW68402">
        <property type="protein sequence ID" value="ADW68402"/>
        <property type="gene ID" value="AciX9_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1342"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_5_0_0"/>
    <dbReference type="OMA" id="ETWGLAV"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="224"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="431" mass="47460" checksum="54C6272A50A194E3" modified="2011-04-05" version="1">MSSSSNLDGSPPRPRTAVRLAYLVSHPIQYQAPLLRRIAAEPGIELTVFFGSDFSVKGYRDEGFGVDVTWDIPLLDGYRHEFLPVLRDKGTEGVFTPISHGLVTRLTNADGSARFDALWVHGYATVNQMHGLLAAKALGIPVLVRSDSSLRDRPRGGAKLLAKKAFFAGLRSLVAGVLVTGTMNREYWQHYMGEDFPLFLLPYAVDNAWWQARCHEAAATRSELQTELGLDPKRPVILFASKMQTRKHCDDLIEAYARLAPAPGTEPEPYLVLVGDGEERAALEAQAAATGLSSIRFCGFRNQSELPRFFDLADVFVLPSRHEPWGLIVNEIMNAACPVIITDDCGCHPDLVTDGVEGFVYPVRDIDALEQALRLTFATPQTATEMGQRALERIENWSFEQDIVGLKQALQHVARKRLAGVDAATSSGDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ1</accession>
    <name>E8WVJ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1380</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579761.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68439">
        <property type="protein sequence ID" value="ADW68439"/>
        <property type="gene ID" value="AciX9_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1380"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_0"/>
    <dbReference type="OMA" id="EEVQNSC"/>
    <dbReference type="OrthoDB" id="1145595at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="40775" checksum="E547BF96522839C1" modified="2011-04-05" version="1">MHEADQIHATALILDAHADTPQRFVDENWSFTGPLDDGMINLATAQEGNLAAEFFAIWVDPTEFPPGTQSDRAFQLIDGVLAQVRSAPEALALCRTPAEILVARKAGKFAIVLAVEGGHAIEDNLEILRTYHQLGVRYMTLTWSHTTTWADSSGDGGHHNGLTDFGKQVIREMNRLGMMVDVSHVSDKTLEDVLATSTAPIIASHSSARALTGAPRNLTDDQIRAIAATGGAVMVNFFPAFIDETWRAAWSALKPERDLAHQAAAAPYRLNGDPVPFAVSNAIDREFAARLERPPLSSLLDHIEHILRVAGEDHIGIGSDFDGIPATPAEIDTAADLIKITRGLYDRGITAEQLHKLLGGNLLRVFQSIQDHATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN5</accession>
    <name>E8WVN5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F1/F0 ATPase, Methanosarcina type, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2534</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580879.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2534"/>
    <dbReference type="EnsemblBacteria" id="ADW69564">
        <property type="protein sequence ID" value="ADW69564"/>
        <property type="gene ID" value="AciX9_2534"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2534"/>
    <dbReference type="eggNOG" id="ENOG50331H5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155951_1_0_0"/>
    <dbReference type="OMA" id="WWTVRKG"/>
    <dbReference type="OrthoDB" id="2045551at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017581">
        <property type="entry name" value="AtpR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12966">
        <property type="entry name" value="AtpR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03165">
        <property type="entry name" value="F1F0_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="10835" checksum="649C3F10E7ABDA53" modified="2011-04-05" version="1">MSETLKVSGAILGGLALGAFFFVGLWWTVRRGVASAHPAVVFLGSMILRTLVVMLGFYCLGRGDWRNVVGSLAGFVAARFIVTRNAPSFAHAKLDIPVEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP1</accession>
    <name>E8WVP1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2540</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580885.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2540"/>
    <dbReference type="EnsemblBacteria" id="ADW69570">
        <property type="protein sequence ID" value="ADW69570"/>
        <property type="gene ID" value="AciX9_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2540"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_0"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="166"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="697" mass="77278" checksum="75117AF38EF10D13" modified="2011-04-05" version="1">MTPIRPLDPVQGTDPGRPFPLGPTVCEKGTNFSLFSANATMVELLLFNGVDDVAPSRTIKLDGERNRTSHYWHMLVCGITPGQLYGFRVHGPDDPAGGFRFDSQKVLLDPYGRSVAVGKNYSRAAGCAPGDTAASCMKSVVVDPSRFDWEDDVPLNHSFRQTVIYEMHVAGFTRNANSGVEENKRGTFLGVVEKIPYLQQLGVTAVELLPVFQFDPQDTPHGLENYWGYDPVSFFAPHLAYGTDSDPLRCMDEFRTMVKALHKAGIEVILDVVYNHTSEGNERGPTVCFRGIENSTYYILNHDKARYANFTGSGNTLKANQSVVKRLILDSLAYWVSEMHVDGFRFDLASVFSRNEAGEPMVNAPIIWEIDSHPALAGTKLIAEAWDEGGLYQVGSFGPDKWKEWNGQFRDDIRAFVKGEQGTVVKLRERITGSLDLYGVGDRPTGQSINFVTCHDGFTVNDLVSYDSKHNEANRENNRDGTDANHSWNCGTEGPSEDQAVSLLRSRQIKNLLALTLLSAGTPMLLMGDEGRRTQGGNNNAYCQNSETSWLDWSLNSHNEELGRFVACLVRLRFGSEVSSDRVRLSLEQYEVEAHYEWHGIELGKPDWKDDSHAIAFTLHTGSLKRLLYVAVNAFWEPLSFALPASNAAGPLGWQRLVDTSLASPNDIVESESGVVVTDARYLVNSRSIVVLQTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS5</accession>
    <name>E8WVS5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3683</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581993.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3683"/>
    <dbReference type="EnsemblBacteria" id="ADW70684">
        <property type="protein sequence ID" value="ADW70684"/>
        <property type="gene ID" value="AciX9_3683"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3683"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_0"/>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="17497" checksum="603B1D57B7F1D898" modified="2011-04-05" version="1">MSMVTLQTTTSQSPTAPNNAPKDPLAGMILLTAEGQQPRAKMAIEITKNALKRVRVAMAKEGISPAQGGLRVGITGGGCSGLSYNIRFDTQPRDRDRTFVFGEGLETPNDPSGGQAVKIFVDPKSFLYLAGMVLDFEETLMRQGFNFINPNSTKSCGCGSSFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT6</accession>
    <name>E8WVT6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl oligopeptidase</fullName>
            <ecNumber evidence="4">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3694</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.26" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70695">
        <property type="protein sequence ID" value="ADW70695"/>
        <property type="gene ID" value="AciX9_3694"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3694"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_0"/>
    <dbReference type="OMA" id="ACMTQRP"/>
    <dbReference type="OrthoDB" id="315644at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234086" evidence="1">
        <location>
            <begin position="21"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="492"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="709" mass="77273" checksum="ADEF0379B4F88733" modified="2011-04-05" version="1">MTWKSTVAAGVLVMSGVAGAQTLKYPAARVSEQKDVYFGTTVTDPYRWMEDVDSAEVKTWVDAENAVTQGFLAGVPARDKIHARLMELSNYERVGMPEREGGRYFYSRNTGLQNQSVLYWQEGEKGEAKVLLDPNTLAKDATIALDSYSVSEDGKLMAYALAEAGSDVQKVRVKVVATGEDLPDLIEWVKFSGVSWAKDGKGFYYSSFGVPKTEAERAAALKQVNTNHKLYFHALGTAQNEDKVVFERPDDKEMLVSGGVSEDGRWLILSSGKGHTNALVVRDLSKPSAGLIQLAQVDDAIYGWVGNVGSKAWLQINKDAPNSKIVEVDLEHPERAAWKTVVAEGKEPIDGVSMVHDELVLSYLEDAKTRVEMRGLDGHVIRQVALPGIGVAHVGGGRAKDTDVFFVFTNYVTPGTVYKLDLKSGATAVWKQPKLVFDPAQYETKQVFAPSKDGTKVPVFITYKKGTKLDGAAPAILYGYGGFNISLGPAYSSSRLAWMEMGGIYAEAILRGGGEYGEKWHEAGTKLQKQNVFDDFIGCAEYLIANKYTSAKKLAINGGSNGGLLVGAVELQRPELFGAVLAQVGVMDMLRFDKFTIGYAWKSDYGSPSDNEAEFKAIYKYSPVHNVHAGTHYPPTLITTADHDDRVFPAHSFKFAAVMQAAAEKTPGAAPMLIRVETRAGHGGGMPLSKQLDVTADMYAFLVKELGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV7</accession>
    <name>E8WVV7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3715</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582025.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3715"/>
    <dbReference type="EnsemblBacteria" id="ADW70716">
        <property type="protein sequence ID" value="ADW70716"/>
        <property type="gene ID" value="AciX9_3715"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3715"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097916_1_2_0"/>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="16832" checksum="4B60207411263B38" modified="2011-04-05" version="1">MIAAIALGSNLSSTFGGREATLHIAVERLGAVGKVTAVSAFYDTEPVGYTDQPRFLNGAVLLETDLSPAELMRTLLGIELGMGRQREGVPAKGPRVIDLDLLFVGDLVVQSAELTLPHPAMHERAFVLEPLAGIAPHWKHPILGLTVVEMLSRLENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY2</accession>
    <name>E8WVY2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ordered locus">AciX9_3740</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3740"/>
    <dbReference type="EnsemblBacteria" id="ADW70741">
        <property type="protein sequence ID" value="ADW70741"/>
        <property type="gene ID" value="AciX9_3740"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3740"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_0_1_0"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="22413" checksum="6A48A4D5F0C3EB1F" modified="2011-04-05" version="1">MPSKLSRVALFGGTFDPPHRGHVAIARAAADRFALDTVLFAPAGRQPLKPEGCSTDYAERLEMTRLVCAEDARFAVSELDAPRKDGQPNYTVRTLEMLAEEMPGAAIFSIAGADSFRSLGHWREPQRLLELADWIVISRPGFLLAEPDGLALTPEQRARVHLLDAVHEDVSATGLRTRLAHGESCDELLTPSVAAFIAEHGLYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW46</accession>
    <name>E8WW46_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0280</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578680.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0280"/>
    <dbReference type="EnsemblBacteria" id="ADW67352">
        <property type="protein sequence ID" value="ADW67352"/>
        <property type="gene ID" value="AciX9_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0280"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_0"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="32153" checksum="ABC92B46C3DA8D5D" modified="2011-04-05" version="1">MKGIILAGGSGTRLHPVTQSVSKQLLPVYDKPMIYYPLSALMLTGIREILIISTPEDTPRFEQLLGDGKRWGISLTYAVQPSPDGLAQAFLIGKDFLAGEGCCLVLGDNIFYGHDFPKNLRAAAANVSGATVFAYAVHDPERYGVVEFDASGKAISLEEKPLKPKSRYAVTGIYFYDAQVVGIAENLKPSPRGELEITDVNRWYMERGQLRTEVLGRGMAWLDTGTHDSLLDASNFIQTIEKRQGLKVSCPEEIAFRLGYIDAEQLRVLAGKIAKSTYGQYLLRLIEEPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW51</accession>
    <name>E8WW51_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
            <ecNumber evidence="4">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0285</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0285"/>
    <dbReference type="EnsemblBacteria" id="ADW67357">
        <property type="protein sequence ID" value="ADW67357"/>
        <property type="gene ID" value="AciX9_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0285"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_0_0"/>
    <dbReference type="OMA" id="GPVFYVQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="50"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="28060" checksum="1F608E198269EB4E" modified="2011-04-05" version="1">MANESHPGDTRAVMVSATDFGFENYEINGRNRTVRVNTLPARLFRYRVVKRIMDITLVAISIPVLVPVLLIVAAVVRFTSPGPIFFSHRRICKDGSFFSMWKFRTMCVNSAEVLDDYLANHPSARSEWNRTHKLKQDPRITSVGLFLRRYSLDELPQIWNVVSGEMSLVGPRPIVAAEVEKYGECFHCYTRVKPGLTGLWQVSGRSKLSYDARVKLDCDYVKTWSLFSDIGILAITFKSVVNQDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW71</accession>
    <name>E8WW71_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1395</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579776.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1395"/>
    <dbReference type="EnsemblBacteria" id="ADW68454">
        <property type="protein sequence ID" value="ADW68454"/>
        <property type="gene ID" value="AciX9_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1395"/>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079895_0_0_0"/>
    <dbReference type="OMA" id="EIETHHQ"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="103"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="27594" checksum="F7996CECB78AEE7E" modified="2011-04-05" version="1">MDLASIGGIVLALAGILAGMMIEGGSIAQITQPTAAMIVLGGTIGAVMLQFPMNIFLAAMKQIVKVFLHKGHDGEAVLAQIVDFANKARKSGIVSLDAELAAVHDPFLKQALMLAVDGTEPSELRKIMQLELDNKSTIEEKIPAVFEAMGGYSPTVGIIGAVLGLIQVMKSLDNIDEVGRGIATAFVATIYGVAVANLICLPAAGKLKFRHAEEVMLKEMMLEGVCSILEGMNPRMIETKLRTFLFESKPGAESASKPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE9</accession>
    <name>E8WWE9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580928.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2588"/>
    <dbReference type="EnsemblBacteria" id="ADW69613">
        <property type="protein sequence ID" value="ADW69613"/>
        <property type="gene ID" value="AciX9_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2588"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_0"/>
    <dbReference type="OMA" id="MVNTDAV"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="273" mass="30818" checksum="15C6279518D92409" modified="2011-04-05" version="1">MSHPMLSIVIPAYNESARIEAALERVMTCIDEQGWDAEVLVVDDGSKDDTGEIVQHWMESFPRLHLIRNPGNRGKGFSVRNGLLQAAGDIVMFTDADLSAPMEEANRLMAAIAAGADVAIGSRWMDRQRQTIHQPLYRQFFGRCFNFITRTVMGLPFKDTQCGFKAFRRPAAQVIFRLQSIERWGFDPEILFIARKLKYSIMEVPVTWGHDERSRMSYLKDGMKMLEEMGVIRYNSLAGRYDAAIAAMKDTSGMVTAPEPAVKNVVKLPSHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI6</accession>
    <name>E8WWI6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recO</name>
        <name evidence="9" type="ordered locus">AciX9_2625</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2625"/>
    <dbReference type="EnsemblBacteria" id="ADW69650">
        <property type="protein sequence ID" value="ADW69650"/>
        <property type="gene ID" value="AciX9_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2625"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_1_0_0"/>
    <dbReference type="OMA" id="GVARHAM"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="27740" checksum="380388DDDE344141" modified="2011-04-05" version="1">MKEGRIAVRVGEAIVLRTWPFHEADLLVSLFTREFGKVKGIARHAMRSRRRFGGALEPMTHVKATWAERPKQELVRLDAFEIMSSPMTAKIDFVRLAGLELVAEVLDELPDGAVEDAVFRLALAVTGAMEVGRVWMPVTYFCLWMTRLMGWMPELGRCVVCGEDLRGRTVWYSGVADGVTCADDRRPGSVGLGAEAVAEALRMFKGTVQDLGAEEWPKERGVALRRFAVETLERHLEKRLVSARALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS3</accession>
    <name>E8WWS3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0329</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578729.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0329"/>
    <dbReference type="EnsemblBacteria" id="ADW67401">
        <property type="protein sequence ID" value="ADW67401"/>
        <property type="gene ID" value="AciX9_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0329"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_0"/>
    <dbReference type="OMA" id="TRIHRAK"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="21118" checksum="755EC8BA960D2869" modified="2011-04-05" version="1">MGVQANGQQTDTATLFTALVDRHSRFLYRVAFSLLNNRQDAEDAVQETFMKLYRTGLWQQTMNDERAYLARAVWRSGLDRIATAQAKAMRRAEDIAELELASDLASPEQDAVDQSDRTLLRTLIDALPSDLRQPLLLSALEDMRSSDVAVTLGIPEATVRTRIHRAKAELRRRFEALATRRATEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY5</accession>
    <name>E8WWY5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ordered locus">AciX9_1493</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579866.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1493"/>
    <dbReference type="EnsemblBacteria" id="ADW68546">
        <property type="protein sequence ID" value="ADW68546"/>
        <property type="gene ID" value="AciX9_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1493"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_0"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="23917" checksum="5CFA4DD4BEBDC88F" modified="2011-04-05" version="1">MGRGFFITFEGLDGSGKTTQLKLLAAALTAEGRTVVSLRQPGGTALGDRIRGVLLDSRSEAALGTIAPLAELALMFADRAQAIAEVIRPALGAGAVVLCDRYTDSSEAYQGAGRELGSERVLALHETVCEGLWPELTVLLLPSLEASLRRARRRNTRHVKEHGTDENRFEREGDAFYGRIHEAYERIAEREPGRVVAVRDDAPVEAIAGKVWEIVAGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX02</accession>
    <name>E8WX02_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579882.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68563">
        <property type="protein sequence ID" value="ADW68563"/>
        <property type="gene ID" value="AciX9_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1510"/>
    <dbReference type="eggNOG" id="ENOG5031K20">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298325_0_0_0"/>
    <dbReference type="OMA" id="EISTIRM"/>
    <dbReference type="OrthoDB" id="1726443at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="24113" checksum="6EADC09203582B8E" modified="2011-04-05" version="1">MSSIFIFPTPNAAFTATVRSEWTRILPDGSKASIFNHRFVARDSSGRVFQERRYLTPQGDKQETEISVLQYDDPNRHERYQCYPQRQMCERSRLYLPTASPAPMPSGPLPNGNGTMVREDLGHKAVQGVDAVGSREITTLKVGAFGNEKVQPVVRELWFSPHLQMNLVTERFDPRASAVQNIYVTDLKRDEPDPKWFQIPSGYRVVGDGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX25</accession>
    <name>E8WX25_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1533"/>
    <dbReference type="EnsemblBacteria" id="ADW68586">
        <property type="protein sequence ID" value="ADW68586"/>
        <property type="gene ID" value="AciX9_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1533"/>
    <dbReference type="HOGENOM" id="CLU_2861458_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7337" checksum="0C247E832365057C" modified="2011-04-05" version="1">MNYKMQRGGVRLRTTVTLLQKHERAKHLFPIHVSLTRPAPDDNTLSGYCSRPNYSSSKTYATQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX58</accession>
    <name>E8WX58_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2676</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2676"/>
    <dbReference type="EnsemblBacteria" id="ADW69700">
        <property type="protein sequence ID" value="ADW69700"/>
        <property type="gene ID" value="AciX9_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2676"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501323_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233944" evidence="2">
        <location>
            <begin position="20"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="543" mass="53097" checksum="06DD77F19767777F" modified="2011-04-05" version="1">MLKHSAFLPCALVSFVLLTGCGVTQSPSATVGPAGPAGAPGLIFLNAYTATLQYVPTDVVTYQGSSYVALATSTGVAPVGATASATDWAVLAQAGATGAPGAVGAVGAAGPQGIPGLSGAQGPAGSPGTAGAQGAVGVAGAQGVQGPVGPIGLTLQSSYLPNQQYAARDVVLYQGSSYVALAANMGVAPLGAAMSGVNWAVLAQAGATGATGLQGPAGLTGAMGPQGPQGAAGPQGMMGLPGATGAMGPQGLMGLQGSTGAMGAIGQQGTPGVAGAQGTQGPAGAAGAQGSQGVAGSQGPTGATGATGPAGPSGTSAVSYLQNRKLGVQGDSFSALFNNAWQNVVTSRTGMTLAVQEAHPGKRFDTAFECWSNPAVGGMLGPFTASHNLSGTGGTCAQATFGISDGTLFADSLANVDLEVIELGTNDQSTTLGQLGDATNSGTYYGNMRWVVENYLNAKPTLRVVMVTLQFNNFASAATNQQYADATVAYGNSIGIPVINMFKLGGVNAISSPVLLRDGAHPSDFAFANFYGPVIAQQLQTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH8</accession>
    <name>E8WXH8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glk</name>
        <name evidence="3" type="ordered locus">AciX9_0439</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the bacterial glucokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578839.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0439"/>
    <dbReference type="EnsemblBacteria" id="ADW67511">
        <property type="protein sequence ID" value="ADW67511"/>
        <property type="gene ID" value="AciX9_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0439"/>
    <dbReference type="eggNOG" id="COG0837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042582_0_0_0"/>
    <dbReference type="OMA" id="NNHWRLS"/>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00524">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00749">
        <property type="entry name" value="glk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="5"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="37379" checksum="3CE0DFCD2E842BE4" modified="2011-04-05" version="1">MILAGDVGGTKVHLALYNFVGGQPKLIRDQKYPATEFGSLDEVVHAFLAVDGDKAAAEVKDVVAACFGCPGPVRDGRIKLTNLPWSLDVRDLRKSLGIEHIFLVNDLEANGYGIAELAPSAIFTLHPGDVTAIGHRGLIAAGTGLGEALLVWDGKKHQPLPSEGGHTDYAPRTDQDIRLLQYLRKTLKGRVSFERVVSGIGIKNVYAFLRDEEGMEEPAWLKERMEKEDPNAVIGTCAEDGSSEICYETMQIFAAAYGAETGNIALKVLAAGGMYLGGGVAPKILKTLQSGKFMEAYLDKGRLSPVLEAIPVRVILDDTCALLGAAAYAESRASELTGHSERVASYHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI7</accession>
    <name>E8WXI7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1550</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579922.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1550"/>
    <dbReference type="EnsemblBacteria" id="ADW68603">
        <property type="protein sequence ID" value="ADW68603"/>
        <property type="gene ID" value="AciX9_1550"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1550"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442038_0_0_0"/>
    <dbReference type="OMA" id="NAMVVHL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="429"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="657" mass="71348" checksum="36D267C26E89C86F" modified="2011-04-05" version="1">MRLKTKLVLAATGSAFVIVIVLSALFLGELLRQRIAQTASANDVMARQVLLMTRQAVEVGLVVHPPENLSNEALQNAVAEALQSHDPLNDTMSSFVRYSPAVQEVSVTDANGLTLVSTDPTMVNQHIASRIAFERVRDGNLPYQWREVFGKPRVLDVSLPLQRNNKPFLIVHIGIRSSFLKDNYAPWLWDALIFALVAGGGSMVAAALLASVAVRPIEEISRRLERLTLSNDSIAAGMELGGGRPVVGALPGSVPDAKTDAVVRVTNTIDRLGQQLRTTEAGYTDLRANFNHVLDTLREGVILFTAEGRAAMVSDAVAQFLRTPDPAGQIVIPHGAMMGKRLEEIFLPTTALGQAVRSAFEQDGKVTGQRVRLEDGREVEISLDRIDAGRGKEHMGTLLTLRDAGSAKQLEQELDVSRRLAAIGRLTAGVGHEVKNPVNAMVVHLELLRAKLEAAGQGRGFLQGAQRHVDILASEMERLDRVVQTLADFTRPMELHLSEIDLREVVERVVDLTGAEMAEHNVEVRCALEPAVMVRADGEMLRQAMLNLMLNAMQAMEQGGILRVGVRRDGDTALLVVADEGPGIPPELMPRIFELYFTTKPKGSGIGLAMTYRIIQMHGGAMEVTSEVGAGAAFTMRLPLILSDNRTGSRLMAGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI9</accession>
    <name>E8WXI9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1552</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1552"/>
    <dbReference type="EnsemblBacteria" id="ADW68605">
        <property type="protein sequence ID" value="ADW68605"/>
        <property type="gene ID" value="AciX9_1552"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1552"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_3_0"/>
    <dbReference type="OMA" id="VRSAQMC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14350" checksum="596FBE818E34605E" modified="2011-04-05" version="1">MGRNQILNWERLASILEAMTDPEITPDAFQALRQQTAGTAGAPVLLDVREPWEIETASLAGSVNIPMGDIPSRAHAELDPDQPIVVMCHHGARSLSVTMWLRREGFEQAQSLAGGIDYWSRAIDPTVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ1</accession>
    <name>E8WXJ1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1554</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579926.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1554"/>
    <dbReference type="EnsemblBacteria" id="ADW68607">
        <property type="protein sequence ID" value="ADW68607"/>
        <property type="gene ID" value="AciX9_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1554"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079636_1_2_0"/>
    <dbReference type="OMA" id="ERYAKGG"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230046" description="DUF4142 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="71"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="224" mass="24171" checksum="47D09ADBEE463FD2" modified="2011-04-05" version="1">MGRNLYYGFILSGGLLMTAPMALGQIDPSGNSAYASNAQMPTPGQQAASHAQQSGMEQESTAARTDPQTMKDKIFLRKAAEGGTAEEELAKLALSKTSNDEVKQFAQKMLDDHASLDVTMKPIAQSLGVMTPKKMNKEDQAEFEKLKALSGTDFDKEYLGAMIKDHRMDLHEFRQESATATDPALKDAATSGSKVIHDHLVAAYKLGVANGVEVPRMPKPEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS5</accession>
    <name>E8WXS5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2746</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581085.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69770">
        <property type="protein sequence ID" value="ADW69770"/>
        <property type="gene ID" value="AciX9_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2746"/>
    <dbReference type="eggNOG" id="COG2323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077149_3_1_0"/>
    <dbReference type="OMA" id="AVPMQNT"/>
    <dbReference type="OrthoDB" id="1884218at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21708" checksum="8798917366D76847" modified="2011-04-05" version="1">MIESMFHMHLPLLEKILRPMIVYLVLIVFLRLFGKRELAQLNPFDLVVLLSLSNTVQNAIIGDDNSVTGGVVGAFALLAINWVLMRILFKVPKLNDALEGTETLLILDGIVDYEALKRETLTEVELLSVLHKQSFDSVSQVRKCVLEPNGTFYVEGMTPSAEDVHSSDLMKAVETLTREVRELRSELNRRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX3</accession>
    <name>E8WXX3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2795</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581133.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2795"/>
    <dbReference type="EnsemblBacteria" id="ADW69818">
        <property type="protein sequence ID" value="ADW69818"/>
        <property type="gene ID" value="AciX9_2795"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2795"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_0_1_0"/>
    <dbReference type="OMA" id="QTREGYY"/>
    <dbReference type="OrthoDB" id="1191010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233970" evidence="2">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="97"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="41118" checksum="CB9DA268C051F382" modified="2011-04-05" version="1">MSISRTSGALALFALSCVLSAQQPDAKIPDKSDKSDKSIEKPTTLTMGTNLVNLPVVVRDKKGALIQTLTKDDFVLQVDGKPQQIRYFDRDADLPLTLGLLVDTSQSQRAALDDERAASTTFLDQMLKGKQDKAFVIQFAHETELLQDLTDSRPKLQAALKDLDSSPQRSSDSSDSDGHRDRGGTVLYDAAFLAADEILSKPKGRKAIILLTDGDDRGSKETITKAIEAAQRADTTVYAIYFKGEEHHDNNNNGGNNRGGRGGGFPGGGGGGMGWPGGGGGGRGGGNGGGQQGGGRGGEQHQDGKKILARMTSETGGRLFEVSKKDTVADIYKQIGEELRAQYRLGYTPDADHSAEGYHQIDLTLKDPKAKLTIQTRDGYYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY56</accession>
    <name>E8WY56_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1631</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580002.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1631"/>
    <dbReference type="EnsemblBacteria" id="ADW68683">
        <property type="protein sequence ID" value="ADW68683"/>
        <property type="gene ID" value="AciX9_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1631"/>
    <dbReference type="HOGENOM" id="CLU_2508071_0_0_0"/>
    <dbReference type="OrthoDB" id="2200956at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9652" checksum="AA6C8FBD5C10540E" modified="2011-04-05" version="1">MPAPVKQCPGEFSPEIQQLLHDNADRAQWKEHPCALCGQFVNAELKFSKWLPLRHWPSVNYAALRNKAAQKKARPTPTPKPVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB4</accession>
    <name>E8WYB4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581135.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2797"/>
    <dbReference type="EnsemblBacteria" id="ADW69820">
        <property type="protein sequence ID" value="ADW69820"/>
        <property type="gene ID" value="AciX9_2797"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2797"/>
    <dbReference type="eggNOG" id="ENOG5032YB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113282_3_0_0"/>
    <dbReference type="OMA" id="WLIVENR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230452" description="DUF4136 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4136" evidence="3">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="20472" checksum="843667DE328322A6" modified="2011-04-05" version="1">MFSIKTVRMAALGCVMGCAAAAFAADVSTDYDHNANFRSYKTFSFYKVQSSDPFFDTRIQAEVTKDLAQAGWTMVPSGGDVMITAVENSKDEKQYNTFYDGLGGGGFGWGGWGGWGGGRWGGPGYSSTSVEKITVGTLMMDMYDAHTHQLIWRGKADSQLSNKGDKNTKKLDKDIDHMLNGFPPKTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB7</accession>
    <name>E8WYB7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2800</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69823">
        <property type="protein sequence ID" value="ADW69823"/>
        <property type="gene ID" value="AciX9_2800"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2800"/>
    <dbReference type="HOGENOM" id="CLU_3356476_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="36" mass="4057" checksum="2FB4B46FE9273311" modified="2011-04-05" version="1">MRTMFVIVCFLLMVLAPCILALYTLPEDANPKGWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ1</accession>
    <name>E8WYJ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0517</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0517"/>
    <dbReference type="EnsemblBacteria" id="ADW67589">
        <property type="protein sequence ID" value="ADW67589"/>
        <property type="gene ID" value="AciX9_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0517"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_12_1_0"/>
    <dbReference type="OMA" id="NGVHEYV"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233494" evidence="2">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="481" mass="50805" checksum="DEE049DB663EE87A" modified="2011-04-05" version="1">MNVMLQIAGISFRCALGMMTAAAACGGALLAQATTVAIAPAVGGSAGTDPGMQAVGNSTATGQTITLTQALNLARANEPSFAAAYAASRVANLDKSIARSALLPSVVYHNQYLFTQSNHVPLSQNSAAGAQATTDQTAPVFIANNGVHEYVSQAVVNETIGLTQFNAVARADAASAIATAELEISRRGLAATVVGLFYGASIAQGKIAIARRALNEAQGFVEQTQQRAAAREVAHADVVKAQLTLQQRQREMADAELMAEKSRLDLGVLLFPDPRTLYEVELPTASNLPTRAETEAAAVSSNPELASAVATLRASNLDVTAARAAYLPDLAFNYSYGIDAAQFAVNGLDGARNLGYSASATLDIPVWDWFATAHKVKQAQIQRDSAKVALSATQRRLVANLEEFYNEARVAYQQLDSLQLSVDTARDSLRLTRLRYTNGEGTVLEVVDAQNSLTTAELAMQDGTVRYQLALANLQNLTGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN4</accession>
    <name>E8WYN4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0561"/>
    <dbReference type="EnsemblBacteria" id="ADW67632">
        <property type="protein sequence ID" value="ADW67632"/>
        <property type="gene ID" value="AciX9_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0561"/>
    <dbReference type="HOGENOM" id="CLU_3099374_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5386" checksum="48A6F87DE8AE35DD" modified="2011-04-05" version="1">MAEETKPVADAVATPEGDNEFAPDQPLTEVPDGLQEPLGSGPDAYKKDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN7</accession>
    <name>E8WYN7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0564</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578963.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0564"/>
    <dbReference type="EnsemblBacteria" id="ADW67635">
        <property type="protein sequence ID" value="ADW67635"/>
        <property type="gene ID" value="AciX9_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0564"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043931_0_0_0"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="44586" checksum="A8548DC88A2FDC09" modified="2011-04-05" version="1">MVAVESGHLLLGLIVGVSILLMLVRPRNIPEVYWVGGGALMLVALRLVPLRLAGRAVAEGSDVYLFLIGMMLLSEVAREHGVFDWLSSLAIRRAEGSATRLFALVYGIGTVVTICMSNDATAVVLTPAILAAVRKAKVESLPHLFTCALIANAASFVLPISNPANLVVFHEGMPPLGQWLVAFGVPSVLSIASTYLVMRVIFRDDLRAAIECEVEDVPLRVEGKVVLAGLALMVGVLLAASALKKDLGLPACCAALAITAVVSIKARSNPLKLAREISWGTLVLVAGLFVMVDAVESLGLLKVTERWLARAMQLAPAVGAAVAGFAVAVANNVVNNLPLGLIAGGTLHAAHAKGLIANAVLIAVDLGPNLSITGSLATILWLLALRKEGLDVGFWRFLKVGMLAMPIALICSLGGALAMQMLASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS9</accession>
    <name>E8WYS9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1717</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580084.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1717"/>
    <dbReference type="EnsemblBacteria" id="ADW68765">
        <property type="protein sequence ID" value="ADW68765"/>
        <property type="gene ID" value="AciX9_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1717"/>
    <dbReference type="eggNOG" id="ENOG5033633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159952_0_0_0"/>
    <dbReference type="OMA" id="LWMHIAV"/>
    <dbReference type="OrthoDB" id="1806423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="13229" checksum="8D50051D02BF267B" modified="2011-04-05" version="1">MAKLTIVFGVLLVAVGVAGFVLTGSHAPTALIPSLIGVILAVCGGVANTPDAKKRALWMHIAVTVGLLGFLGTIKSAFDVFALAHGKEFAHPIAVEEKAGTCLICLLFVAFCIRSFIEARRARVGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ34</accession>
    <name>E8WZ34_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2926</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2926"/>
    <dbReference type="EnsemblBacteria" id="ADW69949">
        <property type="protein sequence ID" value="ADW69949"/>
        <property type="gene ID" value="AciX9_2926"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2926"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_0"/>
    <dbReference type="OMA" id="QLAINCY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13417" checksum="462FD162CEE96BDE" modified="2011-04-05" version="1">MAGSYKDLIVWQRAIQMTLAVYKLSAAFPKDETYGLTSQIRRASVSVASNIAEGYGRGSRGEYRQFLGIARGSNCEVQTQLFIARELGYGTPGLQKDADDLSDQVGKMLHALLDKLNRPSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ92</accession>
    <name>E8WZ92_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein IclR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0623</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579022.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0623"/>
    <dbReference type="EnsemblBacteria" id="ADW67694">
        <property type="protein sequence ID" value="ADW67694"/>
        <property type="gene ID" value="AciX9_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0623"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061792_0_0_0"/>
    <dbReference type="OMA" id="TVAPYNY"/>
    <dbReference type="OrthoDB" id="900860at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="40231" checksum="4B06E623BC55E07F" modified="2011-04-05" version="1">MRKTTKRLYLIPVLSKALDILELLQTENQQMTLEAIHRETKISKTTVYRILKTFVHRGYLSQSQDGLYRQVSRPKKMRFGFGGQSAEMPFSNEVTESLKLAAASVGVDLMILDNSYDGPTAIRNVEQFVEARVDLIIEFQVEQNVAPIIADKIAAANIPLIAIDIPHPHATFFGVDNYRVGVEAGEVLAAHAVRHWSGKVDWILGLDLPEAGQLVQSRITGAFEGVRATIADLPDECFVRMDGRGIRERSRKLVSDFLQRHPKDKHILLAAATDTSALGALDAVREQKRERNVVIVGQDCIAEAIAEMRVPNSPMIASISHETGSYGQNLIHLGLALLRGQTVAPYNYVNHRLVTRETLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA5</accession>
    <name>E8WZA5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0636</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579035.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0636"/>
    <dbReference type="EnsemblBacteria" id="ADW67707">
        <property type="protein sequence ID" value="ADW67707"/>
        <property type="gene ID" value="AciX9_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0636"/>
    <dbReference type="eggNOG" id="ENOG502Z7VP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094210_0_0_0"/>
    <dbReference type="OMA" id="DLIPDMF"/>
    <dbReference type="OrthoDB" id="1342039at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024423">
        <property type="entry name" value="DUF3050"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11251">
        <property type="entry name" value="DUF3050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="267" mass="29371" checksum="7A6BFA7B9BD34BB5" modified="2011-04-05" version="1">MSNALIESPATISPALEVLQERLAPLYAKLAAHPLYRSFHSVADVRMFMATHVFAVWDFMSLLKTLQRGLTSVEVPWVPTADASSRRLVNEIVLGEESDAYEGRPVSHFELYLEAMRACGAPTVTIEAVITFLNNGLSVPKALAQAGASRAAQAFVAETFRVIAGGRLHEIAAAFTFGREDLIPDIFRGFIRDQDDRLSGQLTLFRWYLDRHIEVDGDEHGPMALQMVANLCGDDELKWLEAGDAAVEAVEARLALWDAIAAELQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF1</accession>
    <name>E8WZF1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1791</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1791"/>
    <dbReference type="EnsemblBacteria" id="ADW68839">
        <property type="protein sequence ID" value="ADW68839"/>
        <property type="gene ID" value="AciX9_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1791"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OMA" id="TDWFLVM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="32380" checksum="FE97EA14DD7D8333" modified="2011-04-05" version="1">MSFDENRSSHELTILLGIPRRMLSTAVRQPLVAAGVLSLLCFVLASVFAALIAPHDPSRLDLTRRMLAPSTNHWFGTDELGRDILSRIIFGARISLVVSISVVGLSLVVGLFIGCLAGYYGGWIDTLLNVYLTNGFLALPGILMAIAFVAFLGPSLFNLVLALSLSGWVGYARLVRGQVMTIRRREFVEAARALGANDLRILLHHILPNILQPLIVQAAIGMAGAVLSEATLSFLGLGAPPPTPSWGAMLNDARSHLFDSPHMIIFPALALMVVVFSFNLLGDALRELMDPKTKNAMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF2</accession>
    <name>E8WZF2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1792</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580159.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1792"/>
    <dbReference type="EnsemblBacteria" id="ADW68840">
        <property type="protein sequence ID" value="ADW68840"/>
        <property type="gene ID" value="AciX9_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1792"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_1_0"/>
    <dbReference type="OMA" id="ICGHSHI"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="16626" checksum="AFC908A8A35D1FAE" modified="2011-04-05" version="1">MNGVFKVGIISDTHGLLRPEAVEALAGVDHILHAGDVGNPEILERLREIAPLTAIRGNVDTIGSCAALPETEAVELAGVLFYLVHSIGWLDINPFDAGVAVVVSGHSHKAEIGSKQGVLYVNPGSAGPRRFKLPVSIARLEIRGVSIIPRILEMEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG5</accession>
    <name>E8WZG5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1805</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580172.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1805"/>
    <dbReference type="EnsemblBacteria" id="ADW68853">
        <property type="protein sequence ID" value="ADW68853"/>
        <property type="gene ID" value="AciX9_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1805"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_5_0"/>
    <dbReference type="OMA" id="VCILIPT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25304" checksum="FDE9629279A7E081" modified="2011-04-05" version="1">MLGRLGQISVIIPALNEAESIGTVVAEMPWGLIGECIVVDNGSSDGTGEIARAAGARVIESARGYGAACLAGSNAALATSDVLVYMDGDGSDIVADMERLTAPIVNGDADFVIGSRIKGRREAGSMLPSQVFAGWLVGTLLRLLQGVKYTDMGPFRAIRRSSLEQMGMSELTYGWNLEMQIKAAQYGLRIREITVDYRCRIGGVSKVSGDWKASIKAAVRIMEVLFRVGLKRRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ5</accession>
    <name>E8WZQ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3008</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3008"/>
    <dbReference type="EnsemblBacteria" id="ADW70029">
        <property type="protein sequence ID" value="ADW70029"/>
        <property type="gene ID" value="AciX9_3008"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3008"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116635_0_0_0"/>
    <dbReference type="OMA" id="IGGMRPF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="18924" checksum="C47C6358A147137F" modified="2011-04-05" version="1">MTSEMTSEMLAVSLETPETLLKSWQGHRRLTRKTIEAFPEEKLFEFSLGGMRTYGHMVLEMIGMTGPVVEGVLSGMWTTFNSGKVATKKEVLALWDEQTMLLQERFPKIPEARFWAMDKAFGQWEMPGIVMIRYAIDNEIHHRGEGYVYLRVLGIEPPAFYDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS1</accession>
    <name>E8WZS1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ordered locus">AciX9_0661</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0661"/>
    <dbReference type="EnsemblBacteria" id="ADW67732">
        <property type="protein sequence ID" value="ADW67732"/>
        <property type="gene ID" value="AciX9_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0661"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_0"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="61"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="43213" checksum="4E3DFB99452204D2" modified="2011-04-05" version="1">MATTMVNPAVEVAGRFGAYGGRYVPETLMAALLELEEAYAEAQADPAFHAELDDLLHHYCGRPTPLYFAKRLTEQCGGAKIYLKREDLLHTGAHKINNALGQGMLARRMGKKRIIAETGAGQHGVATATVCALFGLECVIYMGEEDMRRQELNVYRMRLLGAEVRGVSAGSATLKDAINEAMRDWVTNVRTTYYILGSALGAHPYPTMVRNFHRVISIEARKQFVEETGGLPDVVVACVGGGSNAIGAFYEFLGDKDVRLVGVEAGGRGTALGEHAARFQTVGGGTPGVLQGTYSYVLQNDAGQVSATHSVSAGLDYASVGPEHAMLHDSGRATYVSCSDADALAATVALSRTEGIVPALESAHAVAEGMRMAKGMRTDEVIMVNLSGRGDKDMGILAKELDLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW7</accession>
    <name>E8WZW7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abortive phage infection</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0708</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0708"/>
    <dbReference type="EnsemblBacteria" id="ADW67778">
        <property type="protein sequence ID" value="ADW67778"/>
        <property type="gene ID" value="AciX9_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0708"/>
    <dbReference type="HOGENOM" id="CLU_447413_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="57986" checksum="279FB8E67C5CAF31" modified="2011-04-05" version="1">MPTKTTTNEAAAGNARLYQVLCGVLDDLRAEAPASSALYHPPPSNGDALIQARSRSLLHLFLKSRFGVLAFQQRESFVTDGSNDGGIDAFYIDDQRKVIYLVQSKFRATAGNFASTNMTANDLLKMDVKRILSGELKNESGIPYNDRIKKNLQAAIRRLPDAAGYAREIVLIGNVANLSTAQLKRLVDGYHYEIYPSERIFQELLFPVITGTYYNDPKLLIKINLGNVRGAEAHLDYDAQTKSQKTNIKLIFVPTKEIGRVMMTYRNSILKFNPRSFLELDRNQVNREIEASIRNKSTNEFALFNNGITITTDNTKISQDTGRRGTAQLVLTNPQLVNGAQTAYTLCQIYESCIDSGNFGVFQGKEVLVKVITFVGTAPAKEVKERTFLVAAISKATNAQTKVDDYDRRSNDPLQMDLQKAFYEKFGLLYERKRGEFSDGLRNGYISRDLLVNRENLVRVSLACGFRVNQARAGISKFATEAELAVLLKLSDFPKYAYGYEVLNDLGSLCAGGRFDDVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ8</accession>
    <name>E8WZZ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1848</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580213.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1848"/>
    <dbReference type="EnsemblBacteria" id="ADW68894">
        <property type="protein sequence ID" value="ADW68894"/>
        <property type="gene ID" value="AciX9_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1848"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_2_0"/>
    <dbReference type="OMA" id="VMYGKQS"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234024" evidence="2">
        <location>
            <begin position="23"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="451"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="895" mass="95246" checksum="22C7E3C450667F3E" modified="2011-04-05" version="1">MSLRPIASVCFLATVSAFTANAQSVPAERANEARIDKLLKQMTLEEKMNLIRGDVEPAATNQGQAGYLPGVPRLGVPFLRFADGPPGVLTRIAGQAQTATMGVAATWSAKDAEANGVAIGREARSLGIDVVLQPFINIDRDITFARGYNTLGEDPYLSGVMAAGEVRGEQAQGVMSQAKHYVAYDSDSYNIFVDQQALHEVYVAPFEATIKAGVASIMCSYNKVNGAFACGNADTLKTILRDELGFKGFVTSDWGGVHNVHFINQGLTMEMPGEVPADSPFAGMMKTYFRTRPEDTGAPSKPNLAALAGMLGGTIPEETKGGGMDMNAFPMDSDNATMRSALKDGSITEATVTAAARLVLYEIDRFGYLDGKQKHNVTAQDLEGNGKIIEKTAEDAAVLLKNEGGVLPLKKDASFALIGPTAGQVAAIGTFGERSPGMPERQVGPLEALKKLAPGAKVSFAVADDMTGVPIGAGMLSHDGKPGLERVNEKGVKSVDATLDFTKTNGKALPPNSVVTWKGEVTVAKAGAYWFYLQLLGTRGILSIDGKEVGRSGAVKGTVHGDVQHATQDNGLPTTDGLDNVRRAVELTAGKHAIEVVTSIDTSSAPVQVRLNWMTPEARERDHAAAIAAAKNAGTAVVFVWTRDKPHFELPGEQDKLIEEIAAVNPNTVVVLNTSQPVAMPWIDKVKGVVEMWWPGDEGGVAEAKTLLGLNNPGGKLPMTWGKELTDYAANSPAHPERSTKGVDGKTTFSEGVLVGYRWFDDQKIEPLFPFGYGLSYTKFAMSGLTVKAAGDGGVDVSVKVKNTGSVRGDEVPQVYLDAPATRPAGVQFAPRTLVGFDRVTLEAGEERGVTLHVAPRAFEYWSVDKKQWVKPGGQRTMMVGSSSRELPLNAVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X046</accession>
    <name>E8X046_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1896</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580261.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1896"/>
    <dbReference type="EnsemblBacteria" id="ADW68942">
        <property type="protein sequence ID" value="ADW68942"/>
        <property type="gene ID" value="AciX9_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1896"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_0"/>
    <dbReference type="OMA" id="GEGEKMP"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="595" mass="65010" checksum="889FC31CE80258C8" modified="2011-04-05" version="1">MFDLKTLNDVMAKVTSRGSKQAMLWQDVDGSWKPITSAELYGKIRALAAALKSWGVVKGDRVALLSENRWEWAVTDFACFALGAVDVPLYGTLTPEQLGYSLRDSGSKVAVFSTKEQYEKLAGAGELPALERVVVMDQGEFPDAESFAKIMEAAAGLQVADASFDAAAREVTGDDLATLIYTSGTTGEPKGVRLTHGNIACNLNLSTDPFGFHDTDSSISFLPLSHVTARHLDYAMMCHGARIAYCTKFDLMAAAMKATKPTIFVGVPRVYEKIRQAVEGKSAHSPVKKGILQWAIKTGEKHRPEVLEGKTPSGLAWKIADKLVYSKIREAFGGCAHTFVSGGAPLGMDTAGWFADVGIRIFEGYGLTETSPVIALNYPQTHSIGTVGPVLKNVEVRFAADGELEVKGPSIFKGYWQKEKETAEAFTEDGWFKTGDIGKLENGYLSITDRKKELLKTSGGKLIAPQPVENKLKANTLVGQAAMVGDKHKFACVLISPNFQALEKWAQSQGVGTTDRKELVKDKKVVAEYQRIVDAVNKELPPYETMKRIAVVGDEWSVEDGEMTPSMKMKRRVIEKKYEKEIGEFYADEASATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C3</accession>
    <name>E8X0C3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ordered locus">AciX9_3084</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581418.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3084"/>
    <dbReference type="EnsemblBacteria" id="ADW70104">
        <property type="protein sequence ID" value="ADW70104"/>
        <property type="gene ID" value="AciX9_3084"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3084"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_0"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="13"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="294"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="41655" checksum="08EE5773D4C38C77" modified="2011-04-05" version="1">MSDAVVNLRTTALNATHRTHKAKMVDFGGWDMPVEYSGLIAEHTAVRTAVGLFDVSHMGDIQLRGPGSLAAVQRLLMNDASKLQTGQAHYSAMLYENGTFVDDVVLHKLSDNDYLIVINAGTREKDVQWVRKQIGAMPGVHINDFSDYYTQLAIQGPKAEATLQKLTTTDLSVIKNYWFAWGQVCGCHNVMIARTGYTGEDGFEIYIPSDEPTSSRVWGEVLDAGAEFGIIPCGLGARNTLRLESAMALYGHEISDTINVFEANLGRYCKMDKGTDFVGRDALSEIEFTGGPKRKLVGLEMIDRGIGRDGYPVFTVGGEKIGEITSGSPAPFLKKNIALAYVPTQYAVVDEILAVEIRGALVKAKVVPTPFYKKPKKPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G8</accession>
    <name>E8X0G8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0763</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0763"/>
    <dbReference type="EnsemblBacteria" id="ADW67832">
        <property type="protein sequence ID" value="ADW67832"/>
        <property type="gene ID" value="AciX9_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0763"/>
    <dbReference type="HOGENOM" id="CLU_2843701_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="7158" checksum="994A288F962D3C73" modified="2011-04-05" version="1">MAAMADLLDAPRVVVAERTHDGIYLEFEDGKCAVYPAFFLYASYDMARVLSEADLATSPKVRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P0</accession>
    <name>E8X0P0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1945</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580310.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1945"/>
    <dbReference type="EnsemblBacteria" id="ADW68991">
        <property type="protein sequence ID" value="ADW68991"/>
        <property type="gene ID" value="AciX9_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1945"/>
    <dbReference type="HOGENOM" id="CLU_1893259_0_0_0"/>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="15586" checksum="6E5DA700D7B53A81" modified="2011-04-05" version="1">MEFPKLQIERPKAFGKIWMAQAIGIDATREFPYTVSWVEKELLPRSVVFSPAAEEGLFRLGMVGKVMEFALYHGKFMELTESDFRSYVKKQKVPRPLRADFRWEPVEEFGGWVNASFNLYGGLPFKGFRQNAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T0</accession>
    <name>E8X0T0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">selO</name>
        <name evidence="10" type="ordered locus">AciX9_3094</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3094"/>
    <dbReference type="EnsemblBacteria" id="ADW70114">
        <property type="protein sequence ID" value="ADW70114"/>
        <property type="gene ID" value="AciX9_3094"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3094"/>
    <dbReference type="eggNOG" id="COG0397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_4_1_0"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="514" mass="55824" checksum="C57390CFDBDD5C7F" modified="2011-04-05" version="1">MAMNPLNVLRKVLPTEAAAPLPVHFGFENTYARLPEHFYARLNPTPVAAPRLVKLNVELAVKLGLDPNALASPEGVAILAGNRVAQGSEPLAMAYAGHQFGHFVPQLGDGRANLLGEVMGRDGKRYDIQLKGSGPTPFSRRGDGRAALGPVLREYIVSEAMAAMGVPTTRALAAVMSGEEVMREGFMPGGVLTRVAASHLRVGTFQYFAARGDTDSVRKLADYAIARHYPEAAETAGPYLALLTGVIGRQARLVAQWMMLGFIHGVMNTDNTSISGETIDYGPCAFLEAYHPEKVFSSIDQQSRYAYDNQPRAMLWNLTRLAESLLPLIVEEQGGEEAGLASAKEALAGFQPQFEASRMAGLGRKLGLSMEQEGDAALALDLLERMAANEADFTLTFRRLCDAALDAEADGAVRVLFAVPEAYDVWAAQWRSRLREQPGAAERVAAMRHANPAIVPRNHLVEQALEAAAGQEDFTLFEGLLEAVCHPFEDRPELTKYTTPAQPQEQVRYTFCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T4</accession>
    <name>E8X0T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3098</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581432.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3098"/>
    <dbReference type="EnsemblBacteria" id="ADW70118">
        <property type="protein sequence ID" value="ADW70118"/>
        <property type="gene ID" value="AciX9_3098"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3098"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_0"/>
    <dbReference type="OMA" id="FNEHTTE"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="534" mass="57504" checksum="14CFA0656C6AB806" modified="2011-04-05" version="1">MNNNSGGFTETQHESRAIGATLLAFTLATGMEQWTGNGLSVTLTDLTGTLGSSADEASWAITLYGTAFAVSVALTHRLANLLGNRRLMSFACLLYAVTSLGCAESSTLAPFLCFRVLQGFAGGVFLARTLVFITHQYERKDRAGSLRLYGAGFFFIGRLLAPILSGWFADVLSWRLLFVANVPVMLLAAWLFHRYAAPYWSDDIEEQRADILGIALLLVGICSLQTVLSRGEIDDWFGSNRIILLTTIGVACNLLFVAWQFAPRNRGPLLHLAQLRDRGLFSAAVLGAVLGMLLGGSLYVLPQYLRRVESHSALQTGELMSISGVAGIAMLLIVPQLAKVIMKVGGKAVMAFALFVQMLSMAWLGYIITGDTPDRNLWIPLVLNGIFVGISVPSLALAAFIRMEDKHASSARAIYYGARQLGASLGVTAVVVLIDRRATLHSSRLIESLFSRDLSILGVTIDPNNARRVAGIITKQSLVLTFADVFYAMAALAAAMLLFLPLLPSLEATSPAKVDPEGAASLKPFSGHVIESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X153</accession>
    <name>E8X153_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0851</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579244.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0851"/>
    <dbReference type="EnsemblBacteria" id="ADW67919">
        <property type="protein sequence ID" value="ADW67919"/>
        <property type="gene ID" value="AciX9_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0851"/>
    <dbReference type="eggNOG" id="ENOG5033M4B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2511573_0_0_0"/>
    <dbReference type="OMA" id="VALWRTM"/>
    <dbReference type="OrthoDB" id="2085927at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="9027" checksum="400A9B0EEF67DAA2" modified="2011-04-05" version="1">MGRNLYILAGTLLFFCLVCFGVSFSNIAQQPGSPGDVALWRTMSIAFLVLSMVIALAGTLTSMFEQAERRAEQARQLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X154</accession>
    <name>E8X154_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579245.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0852"/>
    <dbReference type="EnsemblBacteria" id="ADW67920">
        <property type="protein sequence ID" value="ADW67920"/>
        <property type="gene ID" value="AciX9_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0852"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_2_4_0"/>
    <dbReference type="OMA" id="ATWSKEI"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="24944" checksum="7E32A580F12D19B8" modified="2011-04-05" version="1">MKTTQITPNSLQLTRFGLCNCYLVRESSPEGDSFTLIDTTIGGSTDAILAAALTAGAPIRRILLTHAHGDHVGSLDALMKKLGPDTQLAASARSLPLLERKPNKSLRPGEPQAKIKGSLPGTKSIPTHLLAEGELFGSLRVIETPGHIPGHLSFLDERDGTLFTGDALVCVGRLAVSGYAPWFFPLPNVATWHKPTAVASARKLLTYDIARFAAGHGAIRSGGIPALQQALQQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A1</accession>
    <name>E8X1A1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2010</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580373.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2010"/>
    <dbReference type="EnsemblBacteria" id="ADW69055">
        <property type="protein sequence ID" value="ADW69055"/>
        <property type="gene ID" value="AciX9_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2010"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_1_0"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9674" checksum="875C0A827DA53FD7" modified="2011-04-05" version="1">MARQTGKVAWFNNGKGFGFITPETGPDVFVHYSAIMLDGFKTLDEGDTVDFEIETGSTGRPEARKVVRLNHGVLSVQAKAERLEAGTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A5</accession>
    <name>E8X1A5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2014</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580377.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2014"/>
    <dbReference type="EnsemblBacteria" id="ADW69059">
        <property type="protein sequence ID" value="ADW69059"/>
        <property type="gene ID" value="AciX9_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2014"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_0"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="9055" checksum="8BE0194826122652" modified="2011-04-05" version="1">MPLSMSELHEVLTEIVRALVKHPNQVVIKVETLPRIMFVISVADEDLDMVIGKQGRTAHSLRMFTLAAGHQMGSTVSLTITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A8</accession>
    <name>E8X1A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2017</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580380.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69062">
        <property type="protein sequence ID" value="ADW69062"/>
        <property type="gene ID" value="AciX9_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2017"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986140_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="29145" checksum="942482DA7CEEDDAB" modified="2011-04-05" version="1">MQFDSGTYDPASVVIVLGGTLPSGYVSAGYLTKSAAQELFTQSGMNGKKWGVFGDSCTGRASLLSTWQTAVTQRTGMTQVFQDGISGRAYGVATADPNTGTAGAIHGIFSHYGGGNGSGACDTSGISNAQEITFGCTAGNTLAQTVAGLDVLLVVLGPNDAGALASGALTLGNFGDTLTSVTQYGYVQNALTVLSSANPTMRLLVVGNPYTSNGGRADNLLIDTCLETQCAALGIPFLSMYKKYGLNEQTLTSMTQDSVHWTIAAYAERYGPMVVDFILANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D3</accession>
    <name>E8X1D3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2042</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580404.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2042"/>
    <dbReference type="EnsemblBacteria" id="ADW69087">
        <property type="protein sequence ID" value="ADW69087"/>
        <property type="gene ID" value="AciX9_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2042"/>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_2_0"/>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="OrthoDB" id="1401910at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21377" checksum="98F7AFFF8CF2604A" modified="2011-04-05" version="1">MSIATKRGDAGTTGLAGGIRTSKSDLRVESYGTVDELNTVLGFARSICTQTDIAAWTEQIQRILFRVGSALATPPESRKKQPVISTEDVDFLTNLVYQIEATDGILADWSLPGANTQSAAYEMARTVCRRAERLAVRFNETSAPETPLVVPEVLAFLNRLSDVIWLFGRLIEVRAGVDARLRTDDTAGPKFSRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I6</accession>
    <name>E8X1I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) synthase III protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3210</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3210"/>
    <dbReference type="EnsemblBacteria" id="ADW70221">
        <property type="protein sequence ID" value="ADW70221"/>
        <property type="gene ID" value="AciX9_3210"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3210"/>
    <dbReference type="HOGENOM" id="CLU_2752162_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7443" checksum="2A751AF022984ECC" modified="2011-04-05" version="1">MLRSAEEPGPPTVRRCQHICLKSGVANDLSATPLVSAIGGSSLSVIKALHELILTQIREGNVTVLLAYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K2</accession>
    <name>E8X1K2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ordered locus">AciX9_3226</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581549.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3226"/>
    <dbReference type="EnsemblBacteria" id="ADW70237">
        <property type="protein sequence ID" value="ADW70237"/>
        <property type="gene ID" value="AciX9_3226"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3226"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_8_1_0"/>
    <dbReference type="OMA" id="QKWRRLM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="14902" checksum="72C267E0FAB045DC" modified="2011-04-05" version="1">MSQRTFSIIKPDAVKAGNTAAILAEIQKAGFKIVAIKRMSISLAQAEGFYHVHSARPFFGELTQFMSSGPIFPMVLEKDNAIADFRKLMGATNPAQAEEGTLRKLFAASIGENAVHGSDAEDTAAFEIGYFFAGIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X227</accession>
    <name>E8X227_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3259</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581582.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3259"/>
    <dbReference type="EnsemblBacteria" id="ADW70270">
        <property type="protein sequence ID" value="ADW70270"/>
        <property type="gene ID" value="AciX9_3259"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3259"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_0"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="34876" checksum="167420719866FE9E" modified="2011-04-05" version="1">MTPESSIPAAIETRDTVILGSGCSGLTAAIYAARSNLKPLVLEGHEPGGQLSITTLVENFPGWPEGIQGPELIENMKQQATRFGAELRMAHLSSAEFTPGGPIKLNIGGEIVHTRTLIIASGASARWLNLPSEQALIGHGVSSCATCDGFFASGKDIAVIGGGDSAMEEALFLTRFASKVTLINRTEKFRASPIMLERAQAHDKIHFLHNTIVEEVLGVEEKDVKGLRLKNRANGDESTLPVSFMFLGIGHEPNAKAFAGMMDLDDDGYILCKDDVYCTKNGEILPGVFACGDIKDRKYRQAITAAGSGCMAALEVEKYLEEHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E6</accession>
    <name>E8X2E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1014</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1014"/>
    <dbReference type="EnsemblBacteria" id="ADW68078">
        <property type="protein sequence ID" value="ADW68078"/>
        <property type="gene ID" value="AciX9_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1014"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522558_0_0_0"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="58526" checksum="8467F45546C5C1ED" modified="2011-04-05" version="1">MALASLHSAGRAATYVRMSTEHQQYSTENQADTIEKYAVKHNLAIVKRFVDHGKSGLTLAGRVALRDLLLEVESGTADFERILVYDVSRWGRFQDSDEGVFYEYRCKLAGVTVHYCAEQFENDGSLSSSILKTIKRSMAAEYSRELSVKVYAGQCRLIELGYRQGGPAGFGLRRQLVDRDRVPKAILATGEQKSLQTDRVILIPGPDAEISIVREVYKLFTVAGHLEREIAQILNSRGVVTDLRHPWTRGTVHQLLTNPKYIGSNVFNRQSFKLKKKRVKNPSDLWVRRDSAFEAIVPLDLFVRAQEIIQARHYRLPDEEMLLQLRRLWERVGSLSGFLIDEDDNMASSGAFRSRFKSLHRAYRLIGYKPERDFSYIEVNQRLREHHREVCDGIVSQLRSHGAAVESRLSGMLLINGQFTVSLVLARCQELRGGANRWRVRLDTSELPDITIAARLRPGNAEVLDFYLLPSLDRLSHKLALAAENPFALDVYRFDTLDFFMSLSHRRVLWEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q6</accession>
    <name>E8X2Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3345</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3345"/>
    <dbReference type="EnsemblBacteria" id="ADW70353">
        <property type="protein sequence ID" value="ADW70353"/>
        <property type="gene ID" value="AciX9_3345"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3345"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_17_3_0"/>
    <dbReference type="OMA" id="AWNFSGF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="PTHR45826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="442" mass="46957" checksum="141716735A42FA62" modified="2011-04-05" version="1">MTRKMRLLPLIGATYFMVAGGPYGLEDIIGKAGYGRALILLLVIPFVWSLPTSLMVGELASSIPEEGGYYIWVRRALGPFWGFQEAWLSLAASIFDMAIYPVTFVLYLSRIAPALTAGNRGTLWALAVVLGCCLWNLRGAKAVGNGSLWLFAALLSPFVVLIAAGLFRVFTHGPAWSTFSAPVDTPDLAGAVSVCLWNYMGWDNASTVAQEVEDPQRTYPRAMLSAAVLVAFTYVLPLAAVALAGIPAGQFSTGAWADAARQLGGPGLAFAVVLGGTISGAGMFNALMMSYTRIPYALAKEGLLPRAFTRVTPTGVPWLSVLLCAIAWALALRLTFERLISIDLVLYGAALLLEFISLAVLRHRAPEMPRPFRIPGGTLVAAAIGICPAALIAFALYAARDEKVAGIPALAFAGIVAITGPVIYLLARQFRTPAQSASGSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X316</accession>
    <name>E8X316_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ordered locus">AciX9_1087</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579473.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1087"/>
    <dbReference type="EnsemblBacteria" id="ADW68150">
        <property type="protein sequence ID" value="ADW68150"/>
        <property type="gene ID" value="AciX9_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1087"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_3_0_0"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="21423" checksum="D3FDF49909AD52AF" modified="2011-04-05" version="1">MSMRIGFGFDSHSFKAGVPLVIGGLEIDHTEGLAGHSDGDVLLHAITDALLGAVSAGDIGTFFPPSDPRWKGAASSLFLRTALEEIHSAGYKIVNVDTVLVMMRPKIVPIANELRERVAELLEIKPGEVGIKAKTPEGLNQDGVAVAYATVLLESLASGEGSSKMAATADIEDVNEVVESLVVGVRDTSALGRKVPAFDTDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L8</accession>
    <name>E8X3L8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ordered locus">AciX9_1146</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579532.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1146"/>
    <dbReference type="EnsemblBacteria" id="ADW68209">
        <property type="protein sequence ID" value="ADW68209"/>
        <property type="gene ID" value="AciX9_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1146"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_0"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="28296" checksum="7C366EEC8C510A5F" modified="2011-04-05" version="1">MIPTQDPIISTAAPGAIQPAQGAIQPSADVQQMFNAIANRYDVMNHVLSAGIDRLWWWRAARAVRTVLADPSAQIVDLCCGTGDMTLALLKRRPSTSSTAPLLAVDFSHEMLTRGQAKFNGKNIIAVECDALHLPLPQGNVDLISSAFGFRNLSSYEDGLAELFRVLRPGGQIAILECNQPAGLVGALYNLYFKKILPRIGALFSNAEAYSYLPASVERFPRPPRMLELIHNAGFVQASWTSYTLGVAGLYQATKPVPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q0</accession>
    <name>E8X3Q0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2290</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580644.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2290"/>
    <dbReference type="EnsemblBacteria" id="ADW69328">
        <property type="protein sequence ID" value="ADW69328"/>
        <property type="gene ID" value="AciX9_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2290"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_2_0_0"/>
    <dbReference type="OMA" id="MEFWKIL"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15612" checksum="753C6A8BD3456F56" modified="2011-04-05" version="1">MPIAHLSRRYHFSASHRLHADTLSAAQNQATFGKCNNPYGHGHNYTVEVCFSGPVDPATGMVTNLADLDAFAHAHLLAPFDQTNLNTLALFADLVPSTENLSIELHKIFLTYPHARLERIHIEETPNNSFDYAGPAHLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q2</accession>
    <name>E8X3Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2292</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580646.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2292"/>
    <dbReference type="EnsemblBacteria" id="ADW69330">
        <property type="protein sequence ID" value="ADW69330"/>
        <property type="gene ID" value="AciX9_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2292"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_1_0_0"/>
    <dbReference type="OMA" id="GWLGKPH"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="40290" checksum="20C328780F4C3570" modified="2011-04-05" version="1">MADISENIPAVPQTSPLELTVIVPARNEQDALPACLESLLAQSEPGFELGRHWELIVVDDHSTDETPRIIAQAAQTPGVIALPAPTLEPGRNSGFTGKTSACWAGAQIARGRLFVFTDADTIHEPGDLSRARHELEKYKVALLSYSPRQLVSTFWQRALMPLVFAELATTYPMAKVNDPDNRIAAANGQFLMVEQEAYFSVGGHRAVGPDVLEDVALARNIKRAKHPLRFRYAPDALATRMYRTNAAMVEGWTKNLALLFSNALVMAAMRSLELLLIVGIPTIALVYPFFISWQRAALFVVWFRGLWAFYRRTSRSNFPITDCAIAILGLPLLIVLLLRSYMQVKITKSVEWKGRTYPTDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W3</accession>
    <name>E8X3W3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3466</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3466"/>
    <dbReference type="EnsemblBacteria" id="ADW70471">
        <property type="protein sequence ID" value="ADW70471"/>
        <property type="gene ID" value="AciX9_3466"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3466"/>
    <dbReference type="eggNOG" id="ENOG5032UZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955670_0_0_0"/>
    <dbReference type="OMA" id="HDDPRYY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="32002" checksum="6F42B0E77B8BFE07" modified="2011-04-05" version="1">MHKTYSTHARTEELSPSRSNKIRGISAAVAVLACGLLPAVSFAQAEAQPASLQLVSSSSAAEGTLTATAEPLEVEPVKSDTTALPDAPSFSSSKAPADGEEGTGGFGGQPRAAKPHEAGHLDKIIQPGEIAPRLTVGDKILIGLRANATYTYMAGWVVSAAYEQVVNGAPNYGQTGKGFAQRLGAAAARSASDNIFSDSVLAPILHEDPRYYRLGPGHNFVARFFYAGTRELITRSDSGARTINFADIGGNLGGAALTQWYYPPLNRNVSQVMQTWGSSLGGDAVRNVANEFFPRGILHFGHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X9</accession>
    <name>E8X3X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OmpA/MotB family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3482</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581798.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3482"/>
    <dbReference type="EnsemblBacteria" id="ADW70487">
        <property type="protein sequence ID" value="ADW70487"/>
        <property type="gene ID" value="AciX9_3482"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3482"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073295_0_0_0"/>
    <dbReference type="OMA" id="EGFWGHM"/>
    <dbReference type="OrthoDB" id="1236211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230652" evidence="2">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="30804" checksum="31E682E1B1AA579C" modified="2011-04-05" version="1">MVKSYKVLGTAVLFAVTSFGAVGGSALGQSATSQTTPAQSSTSATSGQADTSTYATGKPLETQSHEGFWGHMNPMARKKWVHRQVDPLKDRVNELDELQAKNANDIRDVDSRATAGISKAMTSAQAADAHAADASSRADQANSLAVSADSHTTALSGTVSNLDQYQAVTSEAVPFTAGRTTLGPKAKASLDDLAAKLASEKGFIVEVQGYSRAGVPQSQAMADSVVRYLVTEHQVPIYRIYRTGLGRATKDQIAAQTASNDGTKPVTNGVRVTLLHNSLATMGSSSSTSAPTPGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y0</accession>
    <name>E8X3Y0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3483</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581799.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3483"/>
    <dbReference type="EnsemblBacteria" id="ADW70488">
        <property type="protein sequence ID" value="ADW70488"/>
        <property type="gene ID" value="AciX9_3483"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3483"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_1_4_0"/>
    <dbReference type="OMA" id="AANLWLT"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="17334" checksum="B37BACC65A6606E7" modified="2011-04-05" version="1">MSTLGMSMDGQGLKQIVELGAAFLLSAVVGLERELRHKSAGLRTYTVVGTSAALFVLISKYGFTDVLQAGRIVLDPSRVAAQIVTGIGFIGAGIIFVQGDRVKGLTTAATVWLVTGIGMACGAGLLVLAVVSTVAYFVVALVFPALLRRFNDGKVPSEEATHTVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y4</accession>
    <name>E8X3Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIM-barrel protein, nifR3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3487</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581803.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3487"/>
    <dbReference type="EnsemblBacteria" id="ADW70492">
        <property type="protein sequence ID" value="ADW70492"/>
        <property type="gene ID" value="AciX9_3487"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3487"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_0"/>
    <dbReference type="OMA" id="APANPWI"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="6">
        <location>
            <begin position="36"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="409" mass="44983" checksum="E20B016ACBBB1B5D" modified="2011-04-05" version="1">MQKHWDNPATNEMPEGTRVPAVLTIGNVRIAPATVLAPMAGVTDTVFRRFIKNASKFTPDSGDTDVDVETSNAQSGCGLIMTEFTSADGLSRMREVKRKRYLTYYDDEHPISAQIFGSNPETLADSARICQDAGFDIVDLNLGCPAKRVVACNGGSGLLRDLPLIETIFKRVRGAISIPFTVKFRMGWNDKNIVCVELAKIAEDCGLNAVALHARTREDGYSGQARWEYIAAVKDAVGIPVIGNGDILTPEDAVAMTHQTRCDAVMIGRAAPANPWIFRQIAQYTETGRYDLATDDDRYRMIKAYFGMLLHEFHEHPEIVGIPGVELTDADKKLQRVKESSLRETLGKMKQFASWFTHGIPGGGGLRKEIFESKSGDAVLGAVERFFDGRRGLVAEEAELVGSSYPFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X403</accession>
    <name>E8X403_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3506</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3506"/>
    <dbReference type="EnsemblBacteria" id="ADW70511">
        <property type="protein sequence ID" value="ADW70511"/>
        <property type="gene ID" value="AciX9_3506"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3506"/>
    <dbReference type="eggNOG" id="COG3797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106303_2_0_0"/>
    <dbReference type="OMA" id="LHVTYFS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="19512" checksum="F0E0B3E2F5DD1359" modified="2011-04-05" version="1">MYLALLRGINVGGKAKLPMKELAAIFTACGATAVRTYIQSGNVVFEAKPHEAAEACVAKVTEEIAKQYGYPGRIVLRSTEELRETFTHNPFLKAGAVESTLHVYFLNDLPAAGAVKALDPLRSEPDAFAVHKRAVYLHLPNGMARTKLTNAYFDSKLKTVSTARNWNTIGKLLEMMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X460</accession>
    <name>E8X460_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0029"/>
    <dbReference type="EnsemblBacteria" id="ADW67120">
        <property type="protein sequence ID" value="ADW67120"/>
        <property type="gene ID" value="AciX9_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0029"/>
    <dbReference type="HOGENOM" id="CLU_2508067_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9432" checksum="1861BDED6AFB9889" modified="2011-04-05" version="1">MAFESGVHRAAGVRRAMAKGPALEMRAMAVEFPEVLGQPGRLHHLEQRVSRNEQGVQRMRGITAAFGTALTMMHFAISYFTGKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X486</accession>
    <name>E8X486_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0055</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578475.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0055"/>
    <dbReference type="EnsemblBacteria" id="ADW67146">
        <property type="protein sequence ID" value="ADW67146"/>
        <property type="gene ID" value="AciX9_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0055"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="PTISTFW"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="326"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="45289" checksum="DCCB36C45A6D3B18" modified="2011-04-05" version="1">MALADQKETVVMALDTLRTNKLRSGLTILGIVIGVMTVIVISSVVNGLNSNVANVVQSLGSNVLFIFRFPVFTGRPTTEMLTRKQMTYDDAVAMRDLPHVVAVAPILQFTDRSNIGGGLGTTSIKAGTHSMQNTTLEGDTPDVETVSEIELSSGRFFTEDDMARSANVTVLGSDTADELFSGTNAIGQEVQAGGMTFTVVGVAARKKQAFGGGKNPDDNKAYFPITTFHKLHPEQLDYWISLKYDDPKNQSLVQDELTELLRRRRKVANEAPDNFSIFGTDTLTRLWNQITGGLFLLLFALASVALMVGGVGVMNIMLVSVTERTREIGIRKAIGATKRTIMAQFTLEAVTLCAVGGIIGVLIGSFLAFVMQFSPVPSQLSTFWVLLAFGSACAIGLIFGIYPAWKAASLNPIEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X489</accession>
    <name>E8X489_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigA</name>
        <name evidence="11" type="ordered locus">AciX9_0058</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578478.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0058"/>
    <dbReference type="EnsemblBacteria" id="ADW67149">
        <property type="protein sequence ID" value="ADW67149"/>
        <property type="gene ID" value="AciX9_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0058"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_7_2_0"/>
    <dbReference type="OMA" id="RDAKKEM"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="10">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="407"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="496"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="242"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="566" mass="65166" checksum="08A91FE7139CAAF3" modified="2011-04-05" version="1">MAEELDKYEDEIVEVGKEKGYLTFGEVNDLLPGDITSPDDLDDLLTTINTQGIELGGDEDRRGRDKYEPEAGEESEDVELDLSPGTLEKTNDPVRMYLREMGTVPLLTREGEVEIAKRIERGQIRVMKAISRSPIVIREIVALGEDLRRGVRNIKEIVTFDEEELTEEILQARVRATVGRIDVIVKHQKKVTALEEKLEQAGALKDAKAKTKEVRKVRWLIGREHVYVNRVIRELKYTNAEKKRLLDKVNKTVDAMRTLERQIKSLEVKFESSKSEELKKEYKRQQKNCKLDLERVEQDAGISIPDLKRTQREMIQGDMDAEKAKRELIEANLRLVVSIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRAIADQARTIRIPVHMIETINKLIRTSRQLVQELGREASSEEIARRMDIPVAKVRKVLKIAQEPISLETPIGEEEDSHLGDFIEDRMAVSPADAVISVNLKEYTSQVLRTLTPREERVIKMRFGLEDGSEHTLEEVGQSFQVTRERIRQIEAKALRKLRHPSRSRKLKAFVDGVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I5</accession>
    <name>E8X4I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2358</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69395">
        <property type="protein sequence ID" value="ADW69395"/>
        <property type="gene ID" value="AciX9_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2358"/>
    <dbReference type="HOGENOM" id="CLU_2219409_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="12195" checksum="8BDCAF5570015917" modified="2011-04-05" version="1">MLAGAGFAAQTLTARVVLAEDSIRYGSVFRSHSMHLNQIRYRREYEEYQDGPEGGINVPYLELIPTSHGETQSLKIPKNDFDLDNAFWEWVLRIPELEELKTSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N1</accession>
    <name>E8X4N1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH:ubiquinone oxidoreductase, subunit G, iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_2404</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580757.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2404"/>
    <dbReference type="EnsemblBacteria" id="ADW69441">
        <property type="protein sequence ID" value="ADW69441"/>
        <property type="gene ID" value="AciX9_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2404"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_0"/>
    <dbReference type="OMA" id="HKNVGPL"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="797" mass="86338" checksum="0D57F87665388C3F" modified="2011-04-05" version="1">MPDVTFTVDGRQLTAPAGTLLIDACKTHGINIPAFCYYPGLSLQAACRMCVVRIEKVPKLATACTTTVAEGMVVATETPEIAQARKATLQLLLGNHPLDCPVCDAGGECELQDMTFKYGAADSFYAEPKNHREEQKWSPVVYFDRPRCILCYRCVRMCGEGMDVFALGIQNRGSSSIIAPNSPASENPMDSLPHVDCEQCGMCIDACPVGALTSGTYRYKTRPWEMNHVSTVCTHCGDGCKTTLGVRSTSGGSEIVRGDNRDKSGINGDFLCNKGRYAFDFANHEDRITKPLVRNAAGKLEPVTWEAAFDHIGKRFRELRDTKGGESIGVIGSNRLTNEESYLLQKFARTVLKTNNIDHHRTADHVAFAQALSGQTGRSASLHDTLSAPSVLIVGGDPTNQSPATAWNLRTNVRNNGAKLYVVNHEEIKLRRQAKAFVRLAPFGYGALAAFLAGDDSAASQAVQNTEALSGFRDTLRGTENLLILIGSDLRGADLRRLIEFGLTLPGSKFALLSDYVNSKGAADMGLLPDMLPGYTPVGSEHFAEYNAPATPGKDMLEIFDAAGAGNLSALYVVGSNPVLRYGVEAAALKNTFVVVQDMFMTETAVLADVVLPASNLYEKSGSVTNHYGDVQQVKKAADRAGVRSDFEMIVRIADRMGAHIQSLVPFGKNVAGTRADMGQTRGAQSGEADRHAVWLTAHSLEPRLSPFDTTAILDEIQRLVPGYDKLLRLQLLSGNDQHLEPAANLVQISTTRRDLVLPSGDTLFTSGTLGHYSAMLLDLQENESRKHIELNQTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U4</accession>
    <name>E8X4U4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3579"/>
    <dbReference type="EnsemblBacteria" id="ADW70583">
        <property type="protein sequence ID" value="ADW70583"/>
        <property type="gene ID" value="AciX9_3579"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3579"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_0_0_0"/>
    <dbReference type="OMA" id="CQRAETI"/>
    <dbReference type="OrthoDB" id="806134at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="98"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="35884" checksum="43F183541FDC5946" modified="2011-04-05" version="1">MGQTAPVATPPAQQTAPQQPVQAPPQEAPGATGLSARPQGQDQPFQLTVRANLVSLVFTVTDKKGRFVKDLHLSDFGLLDNGLQPEKVLDFKQQTDLPLRVGIMLDTSSSIRTRFKFEQDSAIDFFLSVMHQNDRAFVEGFDVQTYLPQDYTNNIDLLDQGIRKLRPGGGTALFDSLYKTCRDQMLALQADNEVRKALILVSDGDDNYSRASMTDAIKMCQRADTIVYTISTDTSPTRGKGGAVLESISGATGGRTFFPIKLEDVAIGFKNIEIELRSQYLLQYRPAEFTQDGKFRTILLRGANRAKDLTVRARTGYFAPRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A8</accession>
    <name>E8X5A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1310</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1310"/>
    <dbReference type="EnsemblBacteria" id="ADW68372">
        <property type="protein sequence ID" value="ADW68372"/>
        <property type="gene ID" value="AciX9_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1310"/>
    <dbReference type="eggNOG" id="COG4914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120522_2_0_0"/>
    <dbReference type="OMA" id="YEPNRID"/>
    <dbReference type="OrthoDB" id="1887834at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18277" checksum="CBAB2F8864AC7709" modified="2011-04-05" version="1">MDMPSREMPVELSKDHLELLSALNGQDVKYLVIGGYAVGVHSEPRATKDLDVFIRQDEQNSEAVFRALASFGAPLAGLTAADFNDGKSFFQMGQPPHRADVLQAISGVEFDECYERRVYAVVNGSLTVPVISAVDLVKNKRTVGRLRDLADVEDILEAQQALKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E4</accession>
    <name>E8X5E4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2456</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580807.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2456"/>
    <dbReference type="EnsemblBacteria" id="ADW69491">
        <property type="protein sequence ID" value="ADW69491"/>
        <property type="gene ID" value="AciX9_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2456"/>
    <dbReference type="eggNOG" id="COG3115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285281_0_0_0"/>
    <dbReference type="OMA" id="SETWRHN"/>
    <dbReference type="OrthoDB" id="234212at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1144" mass="121540" checksum="B0D94788FD153D49" modified="2011-04-05" version="1">MSEGSSSAVATAPKLSSGGAVVARSARSTPSLSAARAPLLQRECSCGGSGSCETCKKSRANEEAKAQLQRSAATPGKGTAPPSVHRVLSSPGQPLDAGARSFMEPRFGRDFSGVRVHHDAEAAESARAVDAHAYTVGQHIAFDQGRYDPGSSSGQHLLAHELAHTVQQGSVSTAPSVLPYGNTPEYNHLENEAEAMAHAVMDRGYVAPAVSHAGPVLSRAKAPPKPVAPTASNKRPKDTSAATASASAEVQTESARDWTNVKTPELKKAGVKAYAFNAANPGIIAVQMSAALELPKEKGSSSVEDLWKSRASAGALEAIIELASGEAKTRSGLKQTRPPTAELRKIWLSKVGWTYGNAPANWAKAGGDKQSFDPPQAGKKTCQVDHILELQFGGNNTSGNMQMLDGEENQYSGRLIFQNLKAQVDVIVDAFKSDGIDVKGVTDVLVHYDKVKMAGTLANCACCGVEEKAKGIRDFDVSEGKSRSGAQGLPYPMKAGAQEATVIVEDDKDKKVALALSNVPENKQASTLISGMSLETWNRPTKVGGTVDASLDTDSRFPKSLKPDAKKKLHLQRGKDGTLKLPPGNPNIAFHFDYLSDGVFKHLEIVDDKYLVGSGTLRPSIPWIPPFDVAFDKDKFAITKPIPTNKLKLPLGGLKFTPGEIGFELAPEFKPYGTIGFTLDAGKRHLLDGSLELSADANGIAAVGDVKVSLPGVDKAEGHIEYRNRQWSGKVEISASDIAKKIKYVQSGQLIVLFSDKGMSAEGTVMMKLPGTSADVKANLLYDGGSKRWVFQGTAHFKPPGLEPTSFEVTYDGDHLSGKGSTGIKFQGVQGTVTVWYKDEKFSGEGTLQIRKGKATGNLHVVMKEKNGHPLFTGDGSITVQLSDNMIATAGIEVAEDQRVKVKGELAFPKPIKLFDGTHGDYKFFEVGISIPIPGASIGTFGLNARIDGSLSAGYKLGPGELRDTKLDGTFYPLEDNPDLDLKFTSTIYVGGSAYISGKISGAIELEAGIARVKGGLAITATASLNGFTASKVTLEYSKGKFTAEADFKLLVALALGLALDAFVEGELGVGWFSVSRRKDWNLASYTYNTGLQFGMALKKPIHYDSVDGVKLPTFNDIEWITPSLEPGNLMDKSFGGASTKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F5</accession>
    <name>E8X5F5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580818.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2469"/>
    <dbReference type="EnsemblBacteria" id="ADW69502">
        <property type="protein sequence ID" value="ADW69502"/>
        <property type="gene ID" value="AciX9_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2469"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_0"/>
    <dbReference type="OMA" id="VYILENC"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="79"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="36145" checksum="F975AD76EE644637" modified="2011-04-05" version="1">MKAFLYGLLALCVVVGATAGLTFYFNPLWVNDLRIRNHMWRQHVQSKYVQVDGYRVHYYEAVTPDRLLRAGSPKGGVPLVLVHGLGSRGEDWSPMIPTLAASGFHVYVPDLLGYGRSERPDVGYSVSLEEQTVVDYMKVMGVPRADVAGWSMGGWIAMKLTLDHPEMVERLVVYDSAGVYFPPTFDASLFTPTDTPGLMKLSAMLTPHPKPFPGFVARAAIRKLHGSGWVIRRSVTAMTSGKDLLDFRLHEIHKPTLIVWGSDDKLIPLSAGEEMHDRIAGSSLLVIGGCGHLAPGECTRPVLRGTLAFLHADPPMRGGQRVVPGVAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F7</accession>
    <name>E8X5F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2471</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580820.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2471"/>
    <dbReference type="EnsemblBacteria" id="ADW69504">
        <property type="protein sequence ID" value="ADW69504"/>
        <property type="gene ID" value="AciX9_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2471"/>
    <dbReference type="eggNOG" id="ENOG502Z8QW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816190_0_0_0"/>
    <dbReference type="OMA" id="WYWTAAR"/>
    <dbReference type="OrthoDB" id="1598703at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230727" evidence="1">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="34921" checksum="69561A13E6CCFF1F" modified="2011-04-05" version="1">MKRFAVGLGMVLSAGMAMGQSCVSQSQMKVEEKDALKLAAYTLALGVQANDDAGVKAQTVAEYAKDFAGVAGVMSDASPKLKGGKAAVEQVYVLDASQMKATGDAQFYCTLNGSTAEADFTIPQLPVGRYGFAMVRFDGAEPWRVSFLLRQEAGKWLLAGIYPKPLSAGGHEGLWYWQQAREFSAKKQPWVAWLYDQEAEVLLQPAPFVSSTHLEKLAGELASAAPPEVKGGVSDAAKLVVKGADGVEYRFTSLGTDNSLGKEKIDVAAHLKVDALGDAAAARKRNLDAMAALVTAHPELKGAFHGVWIFADAPGQTAYATEAAMAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M7</accession>
    <name>E8X5M7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3651</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581965.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3651"/>
    <dbReference type="EnsemblBacteria" id="ADW70654">
        <property type="protein sequence ID" value="ADW70654"/>
        <property type="gene ID" value="AciX9_3651"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3651"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082418_0_0_0"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="27093" checksum="9BD7424EFFDD9511" modified="2011-04-05" version="1">MRLLYRLLLHAIDNHGLRGTILRAIRPPRQSTAAPEPSSPEVHPFDQRHHTDTSGYVPGEALATGTPADLYNTAYYAISPSTLTQAIAALPISPTQYTFVDLGCGKGRALLIAAHQNFRHIAGIELSPTLAASARTNTTTHPNITIQTADAATVLYPPGPLVVFFYHPFLAPLLRKVLTNLTDQSNNRDIYLLSANPGYPKVFARFPMLEQQWTKDFTLSEEDASADRHGILFERYTLWHLPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T0</accession>
    <name>E8X5T0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase, CobN subunit</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4018</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572726.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70814">
        <property type="protein sequence ID" value="ADW70814"/>
        <property type="gene ID" value="AciX9_4018"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4018"/>
    <dbReference type="HOGENOM" id="CLU_002017_1_0_0"/>
    <dbReference type="OMA" id="YQFQGGL"/>
    <dbReference type="OrthoDB" id="8025at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1460" mass="160781" checksum="1A22CC44AA645B08" modified="2011-04-05" version="1">MSTHRQRVIRADGRAFNIVQHRAHLSYCSLGCCCGITERGYAAVPVDVYKEEWLKRKIRNDVHLTQGGCLGPCALANVVSLVFDQKSIWFHSVNGPWLVRQIYDYIDAMLAADRFIQPPSELSEYVFNYYDWDVRLPSPSENPDNLVQLQTPQSTGAIMLLSHADTDLLTLIKASESLPEDLRASAFSLNALKTEDQLQVLITGELSKARVIIVRCHGPLSCIPGFDRLKQACIDRNQSLVLISGCGENTSEFAETVNVPADVTHSAAEYLALGGANNLAEMFRFLSDRLMLTGHGYAAPSPMPEHGIYLPDTDAATYEDWQRQADPTRPTVAVLFYRAHRMSGNTAFIDVLASALDSKGVNALCIFTSSLKAKQDGRPAAFKLIEGRADVLISTLSFALGEVNTGNITLPGESSDSLQHLGIPVLQAIASGMPRGAWEGSRRGLTALDTAVNVAIPEFDGRIITVPISFKERNTASTEGLYVAHEERAARVAGLAARIAALRRTPNKDRRIAFVLTNSAAKASQVGGAVGLDTPASLLTTLRAMRARRYTISSLPDTSDELMQSLLQRGSYDENHPLDPAQAQRFSRAAYGKIFEAFPARPNRRMQDFWGAPQPNGPSILPPKKTDAKLLPTIGGKIVRITQEEPWGDDRDYLFAAMDLGNALIALQPPRGYGIDPDSIYHTPDLPPTHHYTAFYRWLGTPQSEGGWGADAIVHMGKHGTLEWLPGKGIGLSGECYPDLLLGDLPLVYPFIVNDPGEGSQSKRRAHAVIVDHLTPPMTTAETYGALAELNQLVNEYYAVEKLDPAKIPFLQQQIWKLVEETNLKADLDLKTMLTSERGDHSHEWDDTLTPEGIPAQLATMNGNEVAHLIEDLDGYLCELGMAQIRDGLHILGQMPPLPEMLRSLTRLANINTPSLQAALATTFGFDLPTLLDKPGQPLKVTLELLGQPCHTHADALEILDRAALDLYTMLETLGFRPDSIPAVQHAILRAESPDITAALTFACTELVPNLEQSGDEIEHLLDALEGKYIPAGPAGAPTRGMAHILPTGRNFYAVDPRALPSQAAWRVGLQLAHEAIERFRREEGVYPEMMGLSVWGTSQMRTHGDDLAEAFALLGVQPVWNPQSRRMDGITIIPLAELGRPRVDVTLRISGFFRDAFPHLIDIFDQAISQVVELDEPLDQNFPRKHYLADLETHKALPTHEAEAQARYRIFGSKPGSYGAGILPLIETGNWTGDHDFARAFLTWGGYAYGKGADGVDAQPIFAERLKSIQVALHNQDNREHDIFDSDDYFQFHGGMVASIRALTGLQPKAYFGDTSRPESAQVRDLKEEALRVYRSRVVNPKWIDSIKRHGYKGGLELAATVDYIFGFDATAHVAPDFVYEGLAEHYALAPEMREFLAASNPWALTSIAERLLEAARRDLWENPAPETLAALRQVLLDTETVLEARGETHAETRPEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X645</accession>
    <name>E8X645_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4149</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572841.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70929">
        <property type="protein sequence ID" value="ADW70929"/>
        <property type="gene ID" value="AciX9_4149"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4149"/>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_0"/>
    <dbReference type="OMA" id="YVAYPNI"/>
    <dbReference type="OrthoDB" id="1870921at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15739" checksum="106F57A29CEDCEBA" modified="2011-04-05" version="1">MGPFDMLQISGSALSAERQRSEVIAANMANAETTHTDTGGPFKRKEVVFSSASDSSFHLTFAKTGGLSGKTPGTVRISQIVDDTAAPVMRYEPGHPDADKDGFVAYPAINPVQEMVDLMGSTRAYQLNASAVSAAKQMIQQSIDILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E7</accession>
    <name>E8X6E7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4255</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572943.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71031">
        <property type="protein sequence ID" value="ADW71031"/>
        <property type="gene ID" value="AciX9_4255"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4255"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_0"/>
    <dbReference type="OMA" id="LTLMYRV"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="27448" checksum="8B6E6E3B9955A8CC" modified="2011-04-05" version="1">MKTTKTGTPPTVRAKAEHGTSLLTAFREIRELIVHGRLSPGTWILEAELAERLNMSRTPVRGAIHWLQREGYILEHRNVKKSRMIVAPLTKEDANELYMIIGRIEGIAGRGVAVLPLAERKAICSQLKKLNERLELIAKGRDGHPGDIFELDRDFHRLVIKHGAGARLTTLHTAIEPQTERYWRLYASSIIKDLHLSVGEHDAIIQSILAGDADRVEAGLQQNWLKGSERLGHVIEIFGERGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F7</accession>
    <name>E8X6F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4268</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572953.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71041">
        <property type="protein sequence ID" value="ADW71041"/>
        <property type="gene ID" value="AciX9_4268"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4268"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="GSRINWE"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230278" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="464"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1131" mass="120070" checksum="429823BA229E5BF2" modified="2011-04-05" version="1">MTIHQTRLLFVLCAPLLGLASASAQTTGTISGTVKDPSGAIVPGTTVTVTFSSTGSKRIAVTNSAGEYAFPALEPGQYDLEFRSTSFAPLIRHATLSVTERIAVDATLQVTASQQEITVSGDAPILQTADTTLGRVVDGQAIKDLPLATRNFTQILALSPGTSAPLNDATALGRGTTNISADGARPGSNAFYIDGVDAVNIHVNSASNNAFASNGVVVPSPEAIQEFKVQTGLYDVAGGRSGGANVALVTKGGTEHFHGSLFEFFRNDDLNANSYFFNQVGTPRPKLKQNQFGGTIGGPILKQKAFFFFSYQGTRQINGYSGSSTLNLPAIPTVRTAATLGAVFGGQATYKGGTLVSKTGSNINPVSLALLNLKNADGTYVVPSPQTSNITGVNYAVSEPSTFTEDQYVDGLDYQFSSRNHLVFRSVYAKQPQFNSFPSATVPGFGTTQLFNAQLYSVTDTQVITPNLVNEARFGVNRAVGSTGFQNQIPLSSIGESRFNSAQFPDIPSFVLSGSFTLGYSVNADQADADTTYEYFDTLSYVHGKHQMQYGGEARRYQDNYYSNNRTRGTLTIRTFPDFLLGLSGSSVASGGNGSGYSNIYSGSVASGIATRNDILRDYALFAQDSWRLFPNLTLTYGVRWEYVGLPVDKGGRDGAFYLRNYVAPAVGQFTSAGFVQASNTRKAIAGVPQVSNTLTDNVGKLNFGPRLGVAFQPSPRFNIRAGYALSVDRPSNQLGLLESLSLPNYVRTDLSATGNVASTLQNPFPTLPVGSQFPIVPQIYGGPYTNANPALSINDVDPKFRTPYVQQFGLNVQAQAATNTVVEIGYVGSHGVALPLETLVNQAQLASPTNPVNGITTNTTANVQSRVPYVGFSPSGLIYLQTRASSIYNSLQTSVTQRLSHGLQLLASYTYSKSLDTQSSPTDGTTFTTFNGDQTNLAGNYGPSDYDRTNRVVVSGVYSVPAFGFALDHTGLGKKAFSGWQLSGVGTVQSGLPYSVTDASGGAFYGGTTSEASFATGASVATAHLSGKTESRLNQYFNTGSFVAAGNLFGTAGRNILRGPLQRNIDLSLIKQTAIHDSTNFEFRTEFFNILNFANFANPASAISSPTSFGVISATVGNPRIIQFVAKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H3</accession>
    <name>E8X6H3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 29 (Alpha-L-fucosidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4288</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572967.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71057">
        <property type="protein sequence ID" value="ADW71057"/>
        <property type="gene ID" value="AciX9_4288"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4288"/>
    <dbReference type="HOGENOM" id="CLU_002934_0_3_0"/>
    <dbReference type="OMA" id="AWEANMT"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234242" evidence="5">
        <location>
            <begin position="28"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="545" mass="61517" checksum="92022994473A1D6C" modified="2011-04-05" version="1">MPPRLFAFRASVFLALLALVSSPPLWAQAEPLTNKPERLEWFRDQGLGLFIHWSVDSQLGVIISHSLAGASDEYVERFYKELPQTFNPSHFDPDALARLARTAGFRYMVFTTKHHNGFAMWNTTTTPFSITHTPYARDLTSQLFTAFRAQGVAPGVYFSPDDFLWLHNHGKEIQRLVPEVQPSANPGLLALDQQQVTELMTHYGPVSAVFFDGEAKDLRNIVWKLQPDAVVTRGAIETPEQNVPGAPLPGAWEANMTMGTAWGYQPSDEHYKSVQDLLHILIQTRARGGNLLLNVGLKPDGSLPTEQEERLRTLGSWMFVNSDAIYGTRPWVVTNEENIWFTRSRDHNDLYAIFDPEDTAEPWKRGDARDFVLKTVRATPSTTIGILGQNDHIVEYRPNLSPRSTFEQKPDGLHIHVMRAQRLRDSDEWPYPSVIHLTNVEEAFTPPVVHTLSARQSSGEIELQGDWAGAEAPGARFGFDYRIITGEDTRSRLHGWQHLPQQPASHPGSYSATFHPDPQEQYEFRSVLLHPLLTLYGETVSASIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K9</accession>
    <name>E8X6K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3878</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582178.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71159">
        <property type="protein sequence ID" value="ADW71159"/>
        <property type="gene ID" value="AciX9_3878"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3878"/>
    <dbReference type="HOGENOM" id="CLU_132648_1_0_0"/>
    <dbReference type="OMA" id="HAVWIVT"/>
    <dbReference type="OrthoDB" id="1919216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19227" checksum="32A6B1228B3B8819" modified="2011-04-05" version="1">MSKVVFQRQVEDSVPKINDEVAVGEDLDFQRTWWKFERAVWILFALLIMADLAGLFGRGPLADATLISPAMTIHFERIERSGTPSMLHIDFNPSAIQEGKIKLFASESIVNKLGAQRIIPSPETSAIGGGGITYTFPATAVPATVTFALQPDRPGAANFELQVPGASAVQSRVYIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M4</accession>
    <name>E8X6M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3896</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582192.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71174">
        <property type="protein sequence ID" value="ADW71174"/>
        <property type="gene ID" value="AciX9_3896"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3896"/>
    <dbReference type="HOGENOM" id="CLU_803547_0_0_0"/>
    <dbReference type="OrthoDB" id="1073652at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="40417" checksum="5ABF1E816D0C8D66" modified="2011-04-05" version="1">MAYRKILRQLAKRAIFGGERLPARFFLSQVEPQQEVVVWLLVGNKSIDVTKRHCQASGLPFTICIEFTRGSVPTASLRSKLRLRLCEKGGAHRILSEVKLDYRQVIECGESEFLLFNSTKSINFCLPWFRIWSQNLWHSYVDSHRNSKIRVPAAQWRAIVATFSCPRPVSLVSVADDDGHGNIYPLNVMGDLGRNYFGFCLKHDYLPEKFVQRTGRIVLSSVPMKQAPIAYMLGPNHNCPTVDWKRLPFATRPSQIFRIPVPVFACRVRELQVERILRLGYHTFFLSRVLSDERLASVPELCVAHGFYEDWRVRNLGVDKLQATAEDLYVRSPISREVAELISRDSTYITKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R2</accession>
    <name>E8X6R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582230.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71212">
        <property type="protein sequence ID" value="ADW71212"/>
        <property type="gene ID" value="AciX9_3936"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3936"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_0"/>
    <dbReference type="OMA" id="FFIRHQQ"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="45056" checksum="47FD84560181BDEC" modified="2011-04-05" version="1">MKAVGRTHGVRRIDLSSVQLASSEVAREINRDIVLELIRLRQPVSRVDLTKLSGLQPSTIGAIVEQLIEEGWVSQGAVVQGSRGRPSIMLAVNDAIVTFALDLRPDRAILAVVDLSGRFLSRETVMTVSDAQSTVDRIVRKITFLRTRHADKSFEGIGVCVPGRVDPATQRILLAPNLQWHAFDLRAALEKAAKLTVEMDNDANACLLSESWNGHLAGVRDVVLVAISEGIGTAILAGGQLHSGFQGLAGEFGHIPIDPTGPVCGCGQRGCWEMLASSRAALHYYRELSPRSPVIDIYHLLRLTEEGDKHAIAAVTRQAQALGKGLRLITAALAPELILITGEITSCWHHFGPIIQAELEATMLAGPAPKLATAGDGELARLQGAAAVLLQRHASYHRSTHSPRAERKVPSNALVPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U0</accession>
    <name>E8X6U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3964</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582258.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71240">
        <property type="protein sequence ID" value="ADW71240"/>
        <property type="gene ID" value="AciX9_3964"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3964"/>
    <dbReference type="HOGENOM" id="CLU_037612_5_5_0"/>
    <dbReference type="OMA" id="NKPVARW"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009744">
        <property type="entry name" value="VirC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07015">
        <property type="entry name" value="VirC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="25796" checksum="DF2876102560C3C6" modified="2011-04-05" version="1">MPVIAVSNPKGGAGKSTTTLLLATYLAQQGASVSVLDADPNQPIMDWKKNGKSKTTMHVVGNVRENNLMETLEEQPHQFVFIDLEGTASLLVSRSIAMADFVIVPVQASAVDVRQAGKAIRAVRDEEKVAQRSNASRRIPFRVLMTRTPAPGAPVSSVQRQLEAEIEAAGIPRFKTSLAERMAFKALFVERLTLSEMGDLKVGNLEAAYENVHELAEELITLLQAIPGVEAIKGAKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X2</accession>
    <name>E8X6X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3795</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71081">
        <property type="protein sequence ID" value="ADW71081"/>
        <property type="gene ID" value="AciX9_3795"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3795"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_0"/>
    <dbReference type="OMA" id="LTMHDNE"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="44"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26061" checksum="CF857B9AC83C29A5" modified="2011-04-05" version="1">MVMVASAWTRPVIAPLVVALMKGPALTHSTSSFPPAEAAAPSLSVLIVDDHPMVREGLAGILMRSGIEVAGLGATGRQAIELFQSTRPDVVLLDLRLPDSSGVQVLREIRALDADARVVMLTSSQADAEIYSAMSAGASGYLLKGIDGSTLVQQLRHVASGGRAMSPEALEKFTDYLTSRKLSEREIEVLRLVAKGNSNKEIAAQLFVTEDTIKVHVRSMLAKLHASDRTQAVVIAIQRGLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y0</accession>
    <name>E8X6Y0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3803</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582111.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71089">
        <property type="protein sequence ID" value="ADW71089"/>
        <property type="gene ID" value="AciX9_3803"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3803"/>
    <dbReference type="HOGENOM" id="CLU_007853_7_2_0"/>
    <dbReference type="OMA" id="RAHPDTW"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230300" description="Beta-galactosidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_35" evidence="8">
        <location>
            <begin position="33"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="607" mass="67505" checksum="2B9EC3BD2E14BFBC" modified="2011-04-05" version="1">MRSLITAALLLASAPLLAQPPATHRLTTDPQHFLLDGQPFQLISGEMHYPRIPRAAWRDRLRKARAMGLNAVTVYAFWNFHEEEEGHFDFTGQRDIAEFVRIAQQEGLFVILRPGPYVCAEWDLGGYPSWLLKSPAVNLRSLDSRYIAAADKWMKALGQQLAPLQAAKGGPILAVQVENEYGSFPDSAQPNAQAYLDRVHQMVLDAGFKDSLLYTGDGADVLARGTFADLTAGIDYGTGDSARSIALYKKFRPNTNIYTAEYWDGWFDHWGAKHEVVDASIHLKEVHDVLTSGGSISLYMLHGGTSFGWMNGANIDHNHYEPDVTSYDYDAPIDEAGQLRPEYFAMRKVIAEATGHPAPPLAPTTPLATIPTIHLTQAQPLWSTLPKPTLSRTTRTMEDIGQSYGYILYRTTLKGPITGTLKLDRLHSYARIYLDGKLVGTLDRRLDQDHIDLQINKPTQLDILVENTGRVNFTEAIRTEQAGITHQVLLNGTPVENWQIYSLPFESIPTTGFSTKPCEGPCLYHATFNLTTPVDTYLDVHTLSKGNVWVNGHNLGRFWKIGPLGTLYLPSSWLKPGPNKIEVLELDGKPSLEIEGIDHALLDLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X726</accession>
    <name>E8X726_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3849</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582157.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71135">
        <property type="protein sequence ID" value="ADW71135"/>
        <property type="gene ID" value="AciX9_3849"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3849"/>
    <dbReference type="HOGENOM" id="CLU_1127817_0_0_0"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="27126" checksum="1F44B720BF4FB5B0" modified="2011-04-05" version="1">MAWTDIQEKLWRARALDGSDKVQLTSDSLEVFLAHWSPDGKQLAIMAKEHNGVWQNYIIDAAGGKPEPLLHEARNAADPGWSADGSKIVFGREPDLMGKETGSHTIQILDLATHQTETVPGSEGLFSPRWSPDGRWIAALTLDQKSLMLYDVAAHHWRQLGSTSAADPVWSRDSKFIYIHAFQADMEPILKVNVLDGSMQPVADLSSFQSAGAVNYFFGGLSPTNLPMVQTHIGTGNLYTLDLNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A0</accession>
    <name>E8X7A0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UMUC domain protein DNA-repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4383</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71334">
        <property type="protein sequence ID" value="ADW71334"/>
        <property type="gene ID" value="AciX9_4383"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4383"/>
    <dbReference type="HOGENOM" id="CLU_2665962_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8426" checksum="FD14BCFE6626DE6C" modified="2011-04-05" version="1">MSTCEISDLENNYRSRIDCNNFYVSCERVFRPDLEGVPVIVLSNNDGCGVAHSLDYVNIPNSQFGLSWGQILLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C9</accession>
    <name>E8X7C9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71363">
        <property type="protein sequence ID" value="ADW71363"/>
        <property type="gene ID" value="AciX9_4413"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4413"/>
    <dbReference type="HOGENOM" id="CLU_083853_3_1_0"/>
    <dbReference type="OMA" id="SKFGALW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16064" checksum="A90FB721BA85F63A" modified="2011-04-05" version="1">MQEAGVDMKTLSIAAKDTHTDEHVVGYYNAGDRMKYWGKIGAYWGGFWGLLFGSAMFAIPGLGPLLVAGPLVAWIIAGLEGAVVVGGVSALGAGLVSIGIPKDSVVEYETAIKSDKFVLIIHGSFDEVKQAEDVIEASRHKAYTVHGETVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M8</accession>
    <name>E8X7M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4521</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573181.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4521"/>
    <dbReference type="EnsemblBacteria" id="ADW71462">
        <property type="protein sequence ID" value="ADW71462"/>
        <property type="gene ID" value="AciX9_4521"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4521"/>
    <dbReference type="HOGENOM" id="CLU_1649741_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234485" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="17738" checksum="575D74D7D554D4CF" modified="2011-04-05" version="1">MLISLRKLALLSIVIGSSLAGVLLSGCDGEKTGEVVNKTVNDFQNGLETENRAAIQKVGKTISGALDSMNSNPSSLEELQKDFGQFYEVLLDTDVSSCPKDYRDQYAKTLDSIRSFDEILDTITAENSDEQMLHNIQKSRQNMYQQISELKSIAHSYHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T3</accession>
    <name>E8X7T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4587</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4587"/>
    <dbReference type="EnsemblBacteria" id="ADW71517">
        <property type="protein sequence ID" value="ADW71517"/>
        <property type="gene ID" value="AciX9_4587"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4587"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051639_0_0_0"/>
    <dbReference type="OMA" id="PNNGWMA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="333" mass="37263" checksum="FC562CBE863730B5" modified="2011-04-05" version="1">MGHSDKSPTSENTLSQPLVTICVTAYRRPTMILQSLLSCTTQDYRPLEINISDDSPNDLVEKMVRSVAVPEGIKLSYRRNIPSLGEPGNVNSLFEHASGQYLLLLHDDDVLLPGAIRALVNAMADTPAAVAAFGGQDVITDSGELDPIESKAISQRFKQEPHLAGIITDPLLCSLEHRFPNDGYLVESAAARAIGYRSVAEVGRAGDCDFAIRLGLHYQERSFILVADTISQYRLTKGSSRTNVGICWRHYEVLAKMENLTLQQTAARDELMEFYTPYALVDNAVFGQRQKALSIFFAKGYRRQSSFVRRAYHLLLIFFPQIYRLRRFVNLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X834</accession>
    <name>E8X834_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4689</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71618">
        <property type="protein sequence ID" value="ADW71618"/>
        <property type="gene ID" value="AciX9_4689"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4689"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_0_0"/>
    <dbReference type="OMA" id="QVIRYMA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="13881" checksum="9ADE196B615ADBEB" modified="2011-04-05" version="1">MATKKAVAKKTAVPAKKAVGKKAVSTKVAVGSKGAVQKMSKIQVIRYMAEKTELPVGQCAAFLAGLVELALMQTKKNGEFTIPGLGKLVKSQRAARIGRNPATGESIRIAAKTTVKLRISKAAKDVVVPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X835</accession>
    <name>E8X835_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4692</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71619">
        <property type="protein sequence ID" value="ADW71619"/>
        <property type="gene ID" value="AciX9_4692"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4692"/>
    <dbReference type="HOGENOM" id="CLU_2584813_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="9234" checksum="8AB84A5301CBCDE6" modified="2011-04-05" version="1">MPFETVSTSKKMCLSAGFTHYIRAIEERQQEDRSVGKAMDINLRLVVGKLLILAALPFYLHPRHNHDLRPLRVTHDLHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X843</accession>
    <name>E8X843_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573345.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71627">
        <property type="protein sequence ID" value="ADW71627"/>
        <property type="gene ID" value="AciX9_4700"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4700"/>
    <dbReference type="HOGENOM" id="CLU_102900_0_0_0"/>
    <dbReference type="OMA" id="PNHENLF"/>
    <dbReference type="OrthoDB" id="1538348at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="235" mass="25662" checksum="38AAAFB668C02F17" modified="2011-04-05" version="1">MHTDPLWMKVFLTVHVSAGMVSFILAPVALATAKGGTQHRRWGMVYLWSMGVVSCTALPMALFRPVLFLALVSVVSAYLAFSGYRVLKLKDLASGGSARPIDWVAACVALAGSVSLVALGWLRPAAVQHMQVVAILLGSLGTRGIIADLWRFVRRPTDKMFWWYSHLTKFIASYIAAWTAFSTATLSHFFRHAGIILWLWPAAIGVPAIVLTTAYYKRKFAARKPPTLATGLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV70</accession>
    <name>E8WV70_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578573.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0171"/>
    <dbReference type="EnsemblBacteria" id="ADW67245">
        <property type="protein sequence ID" value="ADW67245"/>
        <property type="gene ID" value="AciX9_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0171"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_11_2_0"/>
    <dbReference type="OMA" id="WGIWLIR"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16290" checksum="944AC84E3627A8D2" modified="2011-04-05" version="1">MTYLGDSTQSHVKMKLDSVLASVQTVEESTESFAREAGFDEDDASQIAMVAREAAVNAVVHGNKYDTAKHVTFSCALTDQELRVQVADEGPGLDPESIPNPLAPENLLRSSGRGVFLMKAIMDEVHFRQLTPGTEITLVKRRISKEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI4</accession>
    <name>E8WVI4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4,5-dihydroxyphthalate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1373</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.55" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579754.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1373"/>
    <dbReference type="EnsemblBacteria" id="ADW68432">
        <property type="protein sequence ID" value="ADW68432"/>
        <property type="gene ID" value="AciX9_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1373"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072759_0_0_0"/>
    <dbReference type="OMA" id="YADTTPW"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018796">
        <property type="term" value="F:4,5-dihydroxyphthalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="333" mass="37569" checksum="6B65F07E3CA3EC58" modified="2011-04-05" version="1">MANKKLDLAFWDYDRTRALVDGTVKIDGVDGTFHSAPIVTEIFRGMIADGSFDVSELGFTYFLRTFKDGESPFVAIPVFPNRAFRHSAIFVNKASGIEKPEDLNGKTIGELALYSHDAGIMPKGMLMDEFGFKPETCRWVIGGLDWPLKAIDFVPHTHPANVEVSDIAKGKELGAMLEAGEIDALISADVPKCMLEHSPKVRRLFPDSKQVEQAYYKRTGIFPIMHTVVIRRDLLKQHPELAQAIYQGFCDAKKAAEDKYRHGLIFNSMGTMFPWFSQLVEEDVTVLGEDWWPYGIAANRKSIDAVLRYHHEQGITDRLFTMEDIFLPEFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK2</accession>
    <name>E8WVK2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2499</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580847.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2499"/>
    <dbReference type="EnsemblBacteria" id="ADW69531">
        <property type="protein sequence ID" value="ADW69531"/>
        <property type="gene ID" value="AciX9_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2499"/>
    <dbReference type="eggNOG" id="ENOG502ZGB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508570_0_0_0"/>
    <dbReference type="OMA" id="NLASMAW"/>
    <dbReference type="OrthoDB" id="1972141at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="18588" checksum="B297319DFE0B3D15" modified="2011-04-05" version="1">MSSIGHGFGREPGRHLDEDEFGLAMMGESLGADAQAHVDGCAECRAEMELFTGSVGNFGLAALRWSEAQRPAAMPQKAAAGWRMYPAAGWALAAAVLLGVMVPVTVHFQHGHSAVETAADTGSEIEAGDSAEQIAKDNALLAAVDDELSQSEAQMLAAHGWQAGSASGAKTGLRERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL1</accession>
    <name>E8WVL1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2508</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580855.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2508"/>
    <dbReference type="EnsemblBacteria" id="ADW69540">
        <property type="protein sequence ID" value="ADW69540"/>
        <property type="gene ID" value="AciX9_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2508"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092690_0_0_0"/>
    <dbReference type="OMA" id="IGKECHN"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="19826" checksum="A7E767D875374024" modified="2011-04-05" version="1">MPPHPSTTGTVVSVSRSPIHGFSKDPVAEINILANHGVEGDAHAGPLVQHLYRVRKNPKAPNLCQVHLLPEELFAELRAEGLEVAPGQMGENITVRGLNLIDLPVGALVHLGSTAVVEITGLRDPCNQLNGLRKGLMKACFARDADGTLLRKAGVMATAKVSGPVRPGDLITIHHPPHPWTKMTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM0</accession>
    <name>E8WVM0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2518</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69549">
        <property type="protein sequence ID" value="ADW69549"/>
        <property type="gene ID" value="AciX9_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2518"/>
    <dbReference type="HOGENOM" id="CLU_2752161_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7852" checksum="862FA5CCD091DF1C" modified="2011-04-05" version="1">MENPRLAFPEVVGKSVAELSVYDDATCGREVLVRFTDGTQLSVCVGVKQSIDARYCREDTPDQPIFKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP4</accession>
    <name>E8WVP4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2543</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580888.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2543"/>
    <dbReference type="EnsemblBacteria" id="ADW69573">
        <property type="protein sequence ID" value="ADW69573"/>
        <property type="gene ID" value="AciX9_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2543"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="OMA" id="YLREGEW"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="28173" checksum="B789E78337DCB139" modified="2011-04-05" version="1">MKQRPLKSSSSAVEFDPAVFLASAGLGRRIIKVKVGEALFSQGNAAEYVFYLQTGRAKLTVVSGSGKEATITLLGPGDFVGEESVAAVAGLHMATAVAITACTALKISRAEMLRVMHEEHAFSDMFLAFLVSRSMRIQADLVDQLFNSSEKRLARILLLMAEFGQPGEPEKLIPRISQETLADMIGTTRSRVSFFMNRFRKLGFIEYNGRIHVNKSLLNVILHDQLFEHNAVGAALFPGQPEKSSLTKRQSKAKMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT7</accession>
    <name>E8WVT7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(P)ppGpp synthetase I, SpoT/RelA</fullName>
            <ecNumber evidence="6">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3695</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582005.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3695"/>
    <dbReference type="EnsemblBacteria" id="ADW70696">
        <property type="protein sequence ID" value="ADW70696"/>
        <property type="gene ID" value="AciX9_3695"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3695"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_0"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="476"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="751"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="826" mass="91706" checksum="F430497E6E8C075E" modified="2011-04-05" version="1">MASAPPADSQAGPLNSSSPTTSGSGSVAGIDMEAALPTAASISAASGGVRPQLLSSPIQILPHDLAEPSGSFPPLQPAPISEHPDALPGSLEARFDHLLKTVHRNRPSDDLEIIRRAWAFCIQQHAGQLRASGEPYIIHPLEVCQILADLKMDSTAIAAGLLHDAVEDTDVTSPEIAKRFNEQVAHIVEGVTKLDKIKFANREDHQAENIRKMLLAMVTDVRVVIIKLADRLHNMRTLEHLKPEKQQKIARETLDIYAPLAHRLGMGKLRGELEDLAFRYTDPYAYLQVAQEVEHLRDANEETLTNIVETVRGKLAEAGIDGRVESRIKRLYSIQQKLTAQKIPVDQVYDLLAVRVICHTVGECYAVFGILQNLWRPVPGRFKDFIATPRPNLYQSLHTTLMAPGGHQFEVQIRTEEMHRIAEEGIAAHWKYKANDAVSAKDEQRLAWVRQLMEWQREMTDPNEFMSTLKIDLYPEEVYTFTPKGKVVVLPKDASPIDFSYAIHTEVGNTTIGAKVNGRIVPLRTKLRNGDIVEISTQTGHAPSRDWLSFTKSSRARNKIKHWLNEHQRERAIEIGKKLLDREARKWKLALSKFDDADYVRVANDYGLGTEAELLAGVGFGKYSARVVLNKLQPGSTMAAEISEPEAGVGNVVGQMSEAVKRVFFGKGSDSLQVEGQDDLLVYRARCCNPIRGEEIIGYVTRGKGVAVHARVCPNVQNLLYESDRRIQVEWGLGESHGGAGAPKPTTYPVKLTIVCDDRSGMLKEFTAIIAEDGTNIRSVDSKPATDGSFMVDFVIETVDVRHLTKLTQNLRKVPGVRDVQRVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX7</accession>
    <name>E8WVX7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582045.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3735"/>
    <dbReference type="EnsemblBacteria" id="ADW70736">
        <property type="protein sequence ID" value="ADW70736"/>
        <property type="gene ID" value="AciX9_3735"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3735"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_10_3_0"/>
    <dbReference type="OMA" id="HGAMDYA"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10706" checksum="96E668F35C087C4B" modified="2011-04-05" version="1">MRIELSAFIEGDLSVIADFIAEGAPVRAVTFIQEIRACFARIGKDPLLYQLRPDIGSDARVAVVGRYVILFRIRDEIVKIERVLYGGRDLPNLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW62</accession>
    <name>E8WW62_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578696.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0296"/>
    <dbReference type="EnsemblBacteria" id="ADW67368">
        <property type="protein sequence ID" value="ADW67368"/>
        <property type="gene ID" value="AciX9_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0296"/>
    <dbReference type="eggNOG" id="COG3115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063418_0_0_0"/>
    <dbReference type="OMA" id="HENHIAP"/>
    <dbReference type="OrthoDB" id="1946178at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233426" evidence="2">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="371" mass="39366" checksum="C8F168A279C15B8C" modified="2011-04-05" version="1">MISLSPFRKLVIAASLVAAPAVSHAGIFISVGFAPPALPVYAQPICPGDGYLWTPGYWAYAPSGYYWVPGVWVQPPSVGVLWTPPYWGFAGGVYGFHEGYWGPHVGFYGGVNYGFGYGGSGFYGGRWDGGHFAYNTAVMHVGGGFRNVYVDRTVIVNNNNFNHASFNGGPNGVNARPTPQEAQFSHENHIAPTSMQQSHFQAAQQNRANFASANGGHPQNAAFQRPGMTQGAVAARGATPVVGGNRNGFGTANEVNTRQGNQQARVNQGIRSGQMTPGETRNVENRDASINRQANADRAANGGRLTGQERGQINQRQNNVSQSINNDKHNANNDAAAGARNGATPGQERGAARGQEQHDAPRGGGGEHGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD7</accession>
    <name>E8WWD7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YdjC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1467</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579840.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1467"/>
    <dbReference type="EnsemblBacteria" id="ADW68520">
        <property type="protein sequence ID" value="ADW68520"/>
        <property type="gene ID" value="AciX9_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1467"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_2_0_0"/>
    <dbReference type="OMA" id="IGRDYGM"/>
    <dbReference type="OrthoDB" id="1204930at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="33244" checksum="7CAE00BE61C84548" modified="2011-04-05" version="1">MPARLILNADDFGLTPGINRGIVELHHAGALTSTTLMATAPAFEDAAALARTNPTLGIGCHLTFVDGFPAAHPQSIPTLLGADGKTFRPSLADFAQAALRGTIEPDDIARETQAQIQRLQRAGIDVTHIDTHKHTHIFPAISAPVLHIAQRCGIPAIRYPFEPSWSAKLAQAPFARRVQLRILNLFAPSFRRIAREPALHGFLPTGTLGIAATGTLDAPTLRAILSALPPVGTFELCCHPGHIDSALTSINTRLRASRQQELQALLEVIPELSRTPDAPQLIHYGNLGIPGLQRASGHFEPFTGYEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH4</accession>
    <name>E8WWH4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2613</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580953.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2613"/>
    <dbReference type="EnsemblBacteria" id="ADW69638">
        <property type="protein sequence ID" value="ADW69638"/>
        <property type="gene ID" value="AciX9_2613"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2613"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196895_0_0_0"/>
    <dbReference type="OMA" id="MATTSMK"/>
    <dbReference type="OrthoDB" id="2047774at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="7891" checksum="B822850FFCDE91DD" modified="2011-04-05" version="1">MPIDNALLNKYSLVKGAARRARQLQSGAPPLSNSKSMKACRVAQDEIRAGFVTFVLPERLVAPELPITRAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI2</accession>
    <name>E8WWI2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2621</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69646">
        <property type="protein sequence ID" value="ADW69646"/>
        <property type="gene ID" value="AciX9_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2621"/>
    <dbReference type="HOGENOM" id="CLU_3200392_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="45" mass="5449" checksum="E4DBD4F660713323" modified="2011-04-05" version="1">MFEFLFEFVLDIFFDPFLWVEWMNDRRDKQKTNVTLEASKGLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL7</accession>
    <name>E8WWL7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582070.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3762"/>
    <dbReference type="EnsemblBacteria" id="ADW70762">
        <property type="protein sequence ID" value="ADW70762"/>
        <property type="gene ID" value="AciX9_3762"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3762"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_0"/>
    <dbReference type="OMA" id="RFREHWL"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="31440" checksum="A94F9E8697712FF8" modified="2011-04-05" version="1">MKAVVLHKYGGPDELKVEEWDDPVAGEGQVLIKISSVSINPIDWKMRSGEAKQRFPVEFPGIIGRDVSGIVRAVGAGVENFLPGDKVFTFADHTYAELCVVKASDLAKISEGLDVVKAGALPLVLLTGTQLIRLGAKIQSGQTVLVTGALGAVGRTAVYVARKAGAHVIAGVRKSQLDEAKKIGADEVIALDDSDAVAKLGFLDAIADTVGGETAQTLIGKVKQGGIFATVTGPPQNASQHPTVQIGAVKAVPNPEQLVELAEDVLAGKLEIPIDRMIPLEDAGKGQAAAEKGGLGGKILLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP5</accession>
    <name>E8WWP5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0301</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578701.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0301"/>
    <dbReference type="EnsemblBacteria" id="ADW67373">
        <property type="protein sequence ID" value="ADW67373"/>
        <property type="gene ID" value="AciX9_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0301"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_0"/>
    <dbReference type="OMA" id="SAGIACE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="41893" checksum="38BFD9D42000AF8E" modified="2011-04-05" version="1">MAVRERVEGLELPGDLYGLGVARECEEKKHDGASYIWLAYSIFFFIEPIMRRDAGYWLRQGLIYVFFVGLYVAYVEFIATRVRIGILIAFFVLGIFTMPANPGASCFFIYVAAMLPFSVASLPVLLGTMVVESGTMAIEGYLLPGNRINYIITGFFTVVVGVSNIFVAQQKRADRKLRRAQEENVELAAVAERERIARDLHDVLGHTLSVIVLKAELAGRLMGRDDVRAAVEIAEVEKTARTALAEVREAIGGYRAKGLSAEVEQARVTLDAAGVVLECDSAPPSLRPKEETVLSLAVREAVTNIVRHAGATRCTLRFGRTADGFDLMELTDDGSAGGAVREGNGLRGMRERVVGLGGRLSVEWEAGTRLVVEIPHTPVTGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS1</accession>
    <name>E8WWS1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prolyl oligopeptidase</fullName>
            <ecNumber evidence="6">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0327</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578727.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0327"/>
    <dbReference type="MEROPS" id="S09.076"/>
    <dbReference type="EnsemblBacteria" id="ADW67399">
        <property type="protein sequence ID" value="ADW67399"/>
        <property type="gene ID" value="AciX9_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0327"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_0"/>
    <dbReference type="OMA" id="AWQPAKF"/>
    <dbReference type="OrthoDB" id="315644at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230383" evidence="3">
        <location>
            <begin position="20"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9_N" evidence="5">
        <location>
            <begin position="53"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="502"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="710" mass="78718" checksum="6D140B950E681B46" modified="2011-04-05" version="1">MRIALGCLALAACMGTAFAQDTVIHGKDGIALPAAPKTEKRPVTDTYKVAGATDAKVTDDYRWLEDAKSPATRAYIGAQNAYTQQYLDQVKILPEVRTQMAALLKVDQMSTPTERNGKYFFSRRLADENQASIYMRVGLHGEDVKLIDGNSRSSDGNTSVNLNGITEDGSLLLYGVRVGGADESEVHFFDVASRKDTADVLPSARYYGVQVAPDKKGVYYSRFYPHVGNKVFYHAFGTTTDNDTMLLGGEYRGEKLGEIDGIGVRITANGHYLVMSINRGVPAEREDILLKDLRVKDSPIESLVYGIDSRFSEMNVGDDFYVDTDFNAPNHRVLKAVMGQKPEEWKTVIPEAKDVLEGVNIVGGKMFVLRLHDVKSELTAYTLEGKETGKIALPGIGAGSELSGRVEDKDGFYTFQSIVTPPTIFHYDVVTGKSEVFDTQKVPFNSSAYELKEVFYTSKDGTRVPMFIAGKKGLKRDGSERLLMTGYGGFALSETPVWNPEYAWWMEQGGYFALPDLRGGNEYGEAWHKAAMFEKKQNVFDDWYAAAEYLVANKYTSAAHFAIRGRSNGGLLMGASMTQRPDLFGAIWCGYPLLDMLRYQNFLMGRTWTTEYGSAEDPAQFAYIRAYSPYQNVKMGAKYPAILFFTGDGDTRVDPMNARKMTPLMQEASGSGRPVLLHYSLKGGHSAGVSQTQLVEDYADEMGFLWTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU1</accession>
    <name>E8WWU1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0347</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578747.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0347"/>
    <dbReference type="EnsemblBacteria" id="ADW67419">
        <property type="protein sequence ID" value="ADW67419"/>
        <property type="gene ID" value="AciX9_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0347"/>
    <dbReference type="HOGENOM" id="CLU_1902759_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15388" checksum="A2AA1C99374F6FD6" modified="2011-04-05" version="1">MAPTPPARPAPPAAPKPQPQLNEVFVGFKIGNDGKDADTALTITLTFPNKIIFAQSSGTFGEFESHGSYGNYNIPIVGSTPFLYNQGCSLTISIDPVGHDTWNFDCDLWLMFPGGINRQYNFTGHTLNQNVRSNTFQIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX37</accession>
    <name>E8WX37_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M1 membrane alanine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2654</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2654"/>
    <dbReference type="EnsemblBacteria" id="ADW69679">
        <property type="protein sequence ID" value="ADW69679"/>
        <property type="gene ID" value="AciX9_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2654"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_1_1_0"/>
    <dbReference type="OMA" id="AASWFPC"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233450" evidence="2">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="4">
        <location>
            <begin position="76"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="3">
        <location>
            <begin position="295"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="579" mass="66037" checksum="5ED6D071AD60180D" modified="2011-04-05" version="1">MRMIRTALPACILASSLFAQIAPAPVLPKTPSDTTSTTYPAANAQNTPAPAPATPSRYDVLHAAYGPYRANNDLLYYHLDVRVDPVAKTIAGTNQIRFKMLADGNRIQLDLTDTLQIDSITLNKIPLHYTHDSNAVFIDFPQTLKQGQTYSILFRYSGAPKAKGRFGGMTFEQDPAGRPWITTACEDDGSSIWWPSKDQWKDEPQDGMDISVSVPNALTDVSNGRFVSRIDLHDGYSQWNWHVTYPINSYDVALNIAAYSHFSDTYKSRDFPPLTLDYYALPEDLDKAKAQFPQATNMLKAFEHYFGEYPFARDGYKLIEVPYSGMEHQSAVSYGNHFANGYLNRDWTGVGISPRFDFIIIHESGHEWFGNAITAQDRSSTWIHEGWDTYLETLFVEYHYGRPDAIKYTNGLISKVRNRTPIIPEAWSNQEPPQDMYFKGALMIATLRSVLNDDAKWFSLIHEFYQHFKYQNIMTDDVVAWWNDHTGLYLNPFFNQYLRHTAIPNLELNFDEASQTVLYKWQVDEPGFAMPIRIGEAGTDETHWQTIFPTTTWQSLKTPLTKDQFAAATDLFFINVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC6</accession>
    <name>E8WXC6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein UCP007050, HI0931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0387</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578787.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0387"/>
    <dbReference type="EnsemblBacteria" id="ADW67459">
        <property type="protein sequence ID" value="ADW67459"/>
        <property type="gene ID" value="AciX9_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0387"/>
    <dbReference type="eggNOG" id="COG4316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151222_0_0_0"/>
    <dbReference type="OMA" id="QICWSED"/>
    <dbReference type="OrthoDB" id="1779487at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014449">
        <property type="entry name" value="UCP007050_HI0931"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10008">
        <property type="entry name" value="DUF2251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="15353" checksum="9CC5B1AB27A443D4" modified="2011-04-05" version="1">MESLSFRPGRAFLSSNSPAVPWTVVFEDEGIAGYFYACDRSQTTQENSIMDAMLIYNVGVMQNPETERIASVAWSRNGMQAALYLDGTAQALFDFDAHVGYCRLNFPNFLGEQGDTWQKDTHAWSDAALAKFEAGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT7</accession>
    <name>E8WXT7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581097.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2758"/>
    <dbReference type="EnsemblBacteria" id="ADW69782">
        <property type="protein sequence ID" value="ADW69782"/>
        <property type="gene ID" value="AciX9_2758"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2758"/>
    <dbReference type="eggNOG" id="ENOG5033V95">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101660_0_0_0"/>
    <dbReference type="OMA" id="IDWIRDS"/>
    <dbReference type="OrthoDB" id="1802726at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233969" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27942" checksum="74FA7176FDB76743" modified="2011-04-05" version="1">MIRPLYISALALALTPCAQAQLLGQPPLVQHDAAQDINRIKRDKKAKSKENVEWLWQYSPPPADGREHDLIQDPNFLPFLDQYFTAPQSFWGTDSSGRTGRRKSLAETAYDFLTVPGKVWADNNRYITATGSVFHLRTSRGLLFVDLNGDHPLAVFAAIDWIRDSKTTDQPDAEYTLWLFPNHSTATSANPAYLPGPLIHSLTRWMAEPVPGTGIVQKITAAIVVDPDGTPHQIAVPTEAVQPEGPTLPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX9</accession>
    <name>E8WXX9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578846.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0446"/>
    <dbReference type="EnsemblBacteria" id="ADW67518">
        <property type="protein sequence ID" value="ADW67518"/>
        <property type="gene ID" value="AciX9_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0446"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_2_0_0"/>
    <dbReference type="OMA" id="IDIRKPG"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="18296" checksum="023571C32D20BBE0" modified="2011-04-05" version="1">MWKPNQPGTPQTPEPQRPSTPPVASFDNSPLAPARPAAPSVSAASNAPASGEQATIGKSLIVKGELSGSESLYIDGKVEGAINLPGNRVTVGRNGQVAANIMAREIVVLGKVRGNCHASDRVDIRSEGSLTGDVIAARISIEDGAFFKGGIDIRKPGAGDAKPAATPAAAEKPEPVAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY71</accession>
    <name>E8WY71_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1646</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580017.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1646"/>
    <dbReference type="EnsemblBacteria" id="ADW68698">
        <property type="protein sequence ID" value="ADW68698"/>
        <property type="gene ID" value="AciX9_1646"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1646"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131462_2_0_0"/>
    <dbReference type="OMA" id="YMTALSW"/>
    <dbReference type="OrthoDB" id="1944417at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="14870" checksum="E6F0264EAEDAEDDF" modified="2011-04-05" version="1">MTHRLTSQQYLTLLAVVLTASFGDALLSRGMAQIGQVDLHHLPLLFHALANLNVIAGIFLLIGFFASYMTALSWADLTFVMPATAFGNVVIALISRFILHEHLSLSRWVGILLLTSAVGFVANRPARTDLATAPGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY92</accession>
    <name>E8WY92_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1669</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580038.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1669"/>
    <dbReference type="EnsemblBacteria" id="ADW68719">
        <property type="protein sequence ID" value="ADW68719"/>
        <property type="gene ID" value="AciX9_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1669"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_0"/>
    <dbReference type="OMA" id="DQWGRKG"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="454"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="745"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="839" mass="89412" checksum="034C06A0CCEB18EA" modified="2011-04-05" version="1">MQTALQDLRFAFRQLRRTPGFAITAILTLALGIGANTAIFSLLDQALLRSLPVSDAGKLVVLQGTKSPWNGGTSDSGGDTDAYFSYPMYKDLRDQNQVFSGLIGTSPANAAFRHDNDTHSIDAEMVTGNYFTVLGVQPFLGRMFTQTDDGAVNANPLVVVSYDFWRNQLASDTHIIGSSVSLNDHPFQVIGVAAPSFHSAVWGQTPAVFVPMAMIGQMTTHSGGLDDHKYRWMNILGRMKPGFSAAQAASGVAPLWHSLRAEELKNLGTVTPRFIAGFLTKSRLLVLPGARGFSYKRPNLETPFLAVMAMAVLVLLISAVNVASLLLVRSASRIKEFSLRAALGARIGRIVTQLLMEGLLIGIGGGAIGLLLAPIALRVLVNQLADPDSGTPFSAGIDGRVLLFNFGVAVLVSLIFSLAPALQLRHLNLTSTLRESSSTGSGSLLSLRRLVVCLQIGLSVILLVASGLFLRTMQSLRSVEVGFNTAHLFTFETNLSQAGYAAEARPALNQRIMASLQAIPGVTGVAATDDPELTGNHNMNSAGVAGYQPPPDDSFSIEDPTISADYLNVMQVPLLAGRIFNEQDTVDHPKVAVVNQAFAKHFCGSVEACVGRQMAMTDGFGSTPKMDTTIVGVVRDAKHGGMREDVTATCYRPLHQSPRSADLYFYLRYNGSSSDVLSAVRSTMRQIDPGLALSSVRTMDEQIDQNLSNERMIALLATSFGCLATLLAGVGLYGVLAYSTAQRTREIGIRMALGSTRLAVSRLVLTDVLKLAALGVVVAIPVAMALSSLIRTQLYGVSPADPLILGTVVGLIALVALLAATIPARRAASIEPTSALRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB2</accession>
    <name>E8WYB2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">AciX9_1690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580058.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1690"/>
    <dbReference type="EnsemblBacteria" id="ADW68739">
        <property type="protein sequence ID" value="ADW68739"/>
        <property type="gene ID" value="AciX9_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1690"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_0_0"/>
    <dbReference type="OMA" id="IHYLYSI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="170"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="371" mass="39971" checksum="3838BB3F7FC7E675" modified="2011-04-05" version="1">MLILVLNSGSSSLKFSVFDSERSDEPILQGELHGPALDCVDQVFTRVADLTLDAIGYRVVHPGPKLDRHQRITPEVLQALDAASGFAPLHDPEAVSIIRGGLARYPQLPHFACFDTIFHQTMPTEANTYPIPKSYRDAGVRRYGFHGLACESVVNQLQQTGVPKRLIIAHLGSGCSVTAVVEGRSIDTSMGLTPTGGVVMGTRPGDLDPDLILHLIRQVGGDVEKVEKDLNHASGLAALSGLPNDMKAIRKAAQAGNGDAVLALKVFTRSVRKSIGAYSWLMGGVDAIAFSGGIGEHDAASREEILVELAEQGIEIDSALNNAEQNGMRRVNAPGSNTGIFIVPAQEDLMIANHVKRMMIEETYDDDRRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD1</accession>
    <name>E8WYD1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2814</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581152.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2814"/>
    <dbReference type="EnsemblBacteria" id="ADW69837">
        <property type="protein sequence ID" value="ADW69837"/>
        <property type="gene ID" value="AciX9_2814"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2814"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189441_0_0_0"/>
    <dbReference type="OMA" id="HVQIGPF"/>
    <dbReference type="OrthoDB" id="2018750at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="26433" checksum="22380DE4F576A3C3" modified="2011-04-05" version="1">MNTLLNDRDEDIDELQHRQSRPDRVQDRQRDREITLGTTMVLGIFFALAVLCAAFFGFGYSTGRHSALTAAGPAGAANANSNGILKPGAGSMFGPINNPPQNIQQQPIKTGPVPSYNTQPADQDAEASSAPPTRPAAVQRVVETTEAPAPAPVEQPKAARVLAVSTPVPVTASPAAVGQFMVQVAAVSHQEDADLLVTTLKRRSYGVAVHQEPQDKLLHVQVGPFTNKKDADAMRQRLLADGFNAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI9</accession>
    <name>E8WYI9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0515"/>
    <dbReference type="EnsemblBacteria" id="ADW67587">
        <property type="protein sequence ID" value="ADW67587"/>
        <property type="gene ID" value="AciX9_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0515"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349771_0_0_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="556"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="805" mass="89557" checksum="F87727580A023749" modified="2011-04-05" version="1">MLSNGCEGTSMTGLMMRRWWLVASFAVAGAAYAQKVQPAPSRYDEELKKLGDGLTENMAIRDVHFAKTDDRKHKRFYTEQWDLSATPEYKPSKQFTGTIRVSGNYLVEGTIADQWKQDFERLQPGVKVEMVQEGEVATGDVQIETGPRMKDRLRQASEFEDKLKRSVFDVEWATGSYDVPGWSPGFVIFVQKDNPIAHLSLAQLDGIFGGAHTGGWDGTTWRTDSARGPEKNIRTWGQLGLTGEWADKPIHIYGRPLKYNIQLGFERKVFHGGDVWNENTLEYSHEMNPDGSRYSSSPEMVKDMGNDPYGICFADEASMIPTARAVPVGSTDAGPFMPITLNSLHDRSYPLFIEEWAEVSVAPGKPLDPLTKEFLTFMLSRQGQDAVQKDGKWIPIPSDVSKAAIAKLNEPGKVVRAGKLGLQDAMLAPAKWMGDSPDETGKVNAKKAYYTKRWDLSDLPAYDATTQVTGTIRMPASGLIMASTVGQAWMDGFRKQQPGVTFVKQDGELIDKKVDLELGRKWSSYFAGETLQFQLKYKHSAREIQIGTGSYDVPGYSPAFAIYVNKSNPVTGLTMEQLDGIFGGPRRGGWVSTAFRRQVGRTSEKNIRTWGQAGAPGAWASQPIDVIVPPLKYHIMTVFERKVLEGGNMWNDSIKEYPLLLKADGTRNVPSEERIKRVGMDKDAITFSQEGFPAGQAKALPLAATDGGPFVPPTLENVRNRSYPLSLELYAYADQQPDKPMDPVTKEFLRYILSREGQDMLQRDGKWLPLTAEMVKEQREKLDMVIPPFKNPGTKAKAKAAAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ2</accession>
    <name>E8WYJ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0518</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0518"/>
    <dbReference type="EnsemblBacteria" id="ADW67590">
        <property type="protein sequence ID" value="ADW67590"/>
        <property type="gene ID" value="AciX9_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0518"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_4_0"/>
    <dbReference type="OMA" id="ATMPMKN"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230464" evidence="3">
        <location>
            <begin position="25"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="182"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="460" mass="47742" checksum="3BAB4952EEABB74E" modified="2011-04-05" version="1">MTDKNTVWTTNCGAGLLLAFSLVAMCNLNGCKKAAEEVPKPEVTVQAVHPERGSITEEISADAILAPVAQAAILPKITAPVKKFYVQRGSHVSAGQLVATLENRDLAAAAADNAGAYSAAKGAYTTATETTVPEDATKARLDLAQAKATLDLDNQIVKSREQLFAQGAIPGRDLDTAKATAVQAQATYDLAQQQYEAVKRSGSTASLVSANGTLESAKGKYMGAEAQLSYTNIRTPISGMVTERPLFPGETAAAGAPIVTVMDTSVMLAKVHVAQVQAQHLKIGADAELSVPGMDEPINAKVSLVSPALDAGSTTVEVWLKTPNKDGRLKAGMTLHVTIKGRAVKDAMLVPTEAIQRSSEGAGKIVMVIASDGTAKKRTVMTGIQTPEYTQILTGLKAEDTVITGGGYGLDDGTKVKIGPAEKKEDDDAKPGADADKGTAGEKGGADEKGATAKKEDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL6</accession>
    <name>E8WYL6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0542</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578942.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67614">
        <property type="protein sequence ID" value="ADW67614"/>
        <property type="gene ID" value="AciX9_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0542"/>
    <dbReference type="eggNOG" id="COG1297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018238_0_0_0"/>
    <dbReference type="OMA" id="TPTAYVW"/>
    <dbReference type="OrthoDB" id="809815at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004814">
        <property type="entry name" value="Oligopep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00733">
        <property type="entry name" value="TIGR00733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="792" mass="83810" checksum="D1E1252555674E67" modified="2011-04-05" version="1">MAAPTHFQPFVPASENRPEFSLRALILGAVFAWVFGAVTVYVGLRAGLTVAASIPISVISISVLRVFGKASILENNIVQTIGNAGQSIASGVIFTLPALIFLGFDLESTRIFALALFGGWLGVLFMIPLRRQLIVEEHGTLLYPEGTACADVLIAGERGGSFASRVFFGLGLGALYTFFQNDNIFSLWPSGPNYEPDLGGSQHILKGAAVRADCTPEYLGVGYIIGIRVAAVMLAGGVFSWLVLMPAIYFFGHGLTIYPGTAPIQTMDPSTLWKTYVRPMGAGAVATAGLITLMRTAPTIFSALAEGVRSIRASRASATVKAKTETIRTANDLPMSVVLGGSALLVILIVAFLQFHPVHGAQVGLLANIAAALLVVVFGFLFVTVSARIVGIVGSSASPVSGMTIATLMATCAVFLVKGWTAPAFGALAITIGGIVCIAASNAGDTSQDLKTGYLIGATPWKQQVALIAGVVICVFSIGATLNAMNNGLESFQRVAVPITVTPQMYADGVQQKGQFTRDRVTLTTKAGARETINDGRSYILLNAIGSSTVPDGKYLLNPATNQIVIQWTQGIGSEKAAAPQGKLMATVINGILSRKLPWGLVLLGVALVIVVELLGVRSLTFAVGAYLSIATTLAIFVGGLMRWMVDRAMIHHHAKASAELYQSSLLLWQNDREAFFVRHPDFDETNPDHLDPANGLPVPTSVTPSLDMESEVSPGSLYASGLIAAGGIVGLLGVCIRLLEGLSEQRGGSWQFWRFPASFSAHSPLHDTVSVVMFGLLAFSLYYFARKPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP6</accession>
    <name>E8WYP6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578972.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0573"/>
    <dbReference type="EnsemblBacteria" id="ADW67644">
        <property type="protein sequence ID" value="ADW67644"/>
        <property type="gene ID" value="AciX9_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0573"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075042_0_0_0"/>
    <dbReference type="OMA" id="FHYSEDY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="37204" checksum="E2ECC21D15C14C93" modified="2011-04-05" version="1">MTAQASISTTATDHALSGSSVKILCWSCAATLSSLDTPSAALRCSKCGSVTEFRNGIWCSLAPHLAADYERFVAEYEFIRNAEGRGSLDPTYYHALPYQDLSGKMTAQWKIRARTFDHLLQHILKPLADQRQQPLRILDLGAGNGWLSYRLSRLGHLPVAVDLLTNDRDGLSAGSNFSSQLPVMFPRVQASLDDMPFASETFDLAIFNASFHYSQDYRKTLAEALRCLRPSGTVVIADTPWYAKQESGVMMVEEKHMQFRAAYGFASNSLQSQEFLTPERLEDLARTHELTWQEFRPFYGIKWALRPLIARLKHRRTPSQFRIYTAKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR1</accession>
    <name>E8WYR1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580066.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1698"/>
    <dbReference type="EnsemblBacteria" id="ADW68747">
        <property type="protein sequence ID" value="ADW68747"/>
        <property type="gene ID" value="AciX9_1698"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1698"/>
    <dbReference type="eggNOG" id="ENOG5033VPQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101338_0_0_0"/>
    <dbReference type="OMA" id="TEPFCET"/>
    <dbReference type="OrthoDB" id="2045806at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233499" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="196" mass="20897" checksum="D336E018FFA26C1B" modified="2011-04-05" version="1">MIRKSLVLLAALFAGTTVSAHSQAAVYGLFTVDSISVPPYIAPGNNTNVTKDHLNPIGGTFGVYYDYRTFGPVRLGFDVRGVETTSKVQGIDSFDGAGIRVYSVLGGVRGSFHTPIRALKPYVQGSAGLGRSDRGQPVRTLANHLEYHGFAGLDIKLLPYMDWRAIEAGYGGISFGGTLGTEGVRTLSTGIVFHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU9</accession>
    <name>E8WYU9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1737</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580104.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1737"/>
    <dbReference type="EnsemblBacteria" id="ADW68785">
        <property type="protein sequence ID" value="ADW68785"/>
        <property type="gene ID" value="AciX9_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1737"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_5_0_0"/>
    <dbReference type="OMA" id="CMLTVMG"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14515" checksum="66FA5AFEE070F7FD" modified="2011-04-05" version="1">MVSVEFEYQGNLHCNAVHGPSGTALSTDAPLDNQGLGESFSPTDLVATALGSCMLTVMGIAARSLDVDMTGARAIVEKEMTATPPRRIASLTVKIHMPHAVSPENQERLERAAHTCPVHKSLHPDIQTPIRFTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW3</accession>
    <name>E8WYW3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system permease protein LptF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1751</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580118.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1751"/>
    <dbReference type="EnsemblBacteria" id="ADW68799">
        <property type="protein sequence ID" value="ADW68799"/>
        <property type="gene ID" value="AciX9_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1751"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354437_0_0_0"/>
    <dbReference type="OMA" id="QPRVFYE"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030922">
        <property type="entry name" value="LptF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04407">
        <property type="entry name" value="LptF_YjgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="813" mass="89350" checksum="5ABD228B6ADCC359" modified="2011-04-05" version="1">MRLLTRYILREVLSHALLGGVLFTFVLFTSRLGKILEIVVRNSASLSDVARLIAYFLPEALIVTIPMAVLVGILLGLSRLAADSEITAMRASGMGALDFVRIVSLVSIGALALGLFNSLYLAPRSAANLLALENSLKYSQASFEVEPRVFDEDFKNIVLYVQDVRPGSGAALWRHVFVADLTEPSAPKITTADQALVTSAGPGNLNLHLTDGAQHQISPTDANQYNISTFQVTDIPMQTGAQEDAHLSRSDTPILALSLPELIQRGNQAAAPGPKHDVRAARLYKIELNKRFSYPFACLVLMLVGVPLGLSSKRGGKSTGFVLTILLVFVYYFLSSVGVALANQGKLPPVLGVWGANLIFAAFGALLLQQLSRGGVALSIFSSIGSTISRAFERYRPGQGEENDLSNSIPQRLRSLLHIRFPLILDDYIMREFGATFALVLAAFSMVFLIFTFFELIGDIIRNRIAFVTVGDYLLNLIPYILYNVTPLCVLVAVLVTFGSLAKTSEFTAMKASGVSLYRVVTPVLVLTAVIACSLFAFDEFYLPQANRRQEALRSVIKGKPAQTFLRPDRQWISGQTVLDPISLAQSRSWAPIAPAVVHIGDTAKQPARIFYYQFFDPDHDAFANLTVFEFDPATFTLTRRIFAESAKWDSNVNQWIFENGWSRTFSGEVADTYKPFTLANFPEIHEQPQYFKKEDRQSQQMSFGELSSYISDLRQSGFNTMRLSVQLNRKLAYPAITLVMAILAIPFALSSGKRGGVTGFAIAILLAVVYLGVSSLFEAMGNVNTLPPMLAAWTPDLLFTFAGAYFLLRTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ18</accession>
    <name>E8WZ18_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581248.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2910"/>
    <dbReference type="EnsemblBacteria" id="ADW69933">
        <property type="protein sequence ID" value="ADW69933"/>
        <property type="gene ID" value="AciX9_2910"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2910"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="SMETIEQ"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="138"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1032" mass="111258" checksum="CB8B89568487D6C3" modified="2011-04-05" version="1">MLLSARKFAFGVVLLSWIGLGYGPRSMMAQVQITNGSIQGAVTDAAGAIIQGAAVEADEVDTDTKHEAVTDGSGQFSFPSLKPGPYVVKITKAGFATVIQENLVLTVGRTVSLKLMLPVASGNESVTVTSAPLIDVTTDSSTTTLNEATIATTPVLGRKFEDLLTLTPGVSISQGPDGDEININGQRGIFNNISLDGGDYNNGFFGEQSGGQRAAVDITLEAVKEFQVVASGANAEFGRTGGGVVNVITKSGTNRLHGSVFEYQRLEALTAAASDGTPLTNFHREQAGGSIGGDIIKDKLFYFGAVEGIDENLLRANLSSYNASALGSGACPITNPVFGSNISDAQIEANGDCQRQVLINYYKTNFKEDEGQGVDHVVHNVAAFGRVDYNINAKNLLYGSYNFDFSNNPNQTFDVSTYGTSANGTEGPSHVQTSNFNLISTLSDHILNEAHATYGHETRPRSPINPSAVPDTGIGFFPSFRFGQPFFLGPGASETFYHYDLKDNVSVVKGKHTVKMGGEFLYSHNVQVFDGFALGRYIFGDAVGFLHYASPATLGVAYGPNVQSCGGVVYSTACTGGSPLLLYLQDAGVRPGVTVQQAGYSNISNKEPAVYVQDTWKVLPRLTLNYGLRWEAQFFPKPVIAPSATAYGPNLTDPKFPSTGYLPNQTKQFQPRFGFVYDLAGNGRTVFRGSAGIFNARQNGLTQVGAITTNGVQQQSVSEFSGYGNPTYAGILPIAPLASGFPFQPGVTVFDKNYHNPRIVTFNLGFEQQVKEDYVAFADFTDSKGVYLTRFLNPNVGPVTVPGNNSDTVTYGATGPFPNLGAITDTASNAKSLYRGLTVGLRKRMSHHYQFEAQYTYSVDRDDDSNERDPFTFRYANLYNLGAEYSLADRDERHKFNAFGLGELPFGFKANVRVQQHSAEPETDNPNPVTGASGPACSINNSATRFVGTVDCGRNHLRKDNAFFVFDFGVARPIHFHDSKFELIPRVEVFNTFNNTNNLNPLSSPALFDFSGFLRVGVGDPRQAQLSLRFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ33</accession>
    <name>E8WZ33_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ordered locus">AciX9_2925</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581263.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2925"/>
    <dbReference type="EnsemblBacteria" id="ADW69948">
        <property type="protein sequence ID" value="ADW69948"/>
        <property type="gene ID" value="AciX9_2925"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2925"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_1_0"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="18009" checksum="19C17B64BEA17AFD" modified="2011-04-05" version="1">MRHRNGGFKLGRNTSHRRAMLRNLVTSIILNDRVETTITKCKASRPIVEKMITLGKKGDVHSRRQALAYLMTDESVTRLFNVVSPRYATRPGGYLRIVRTYARKGDAAEMAVIELLGAETELNEKAQKREEARAKKREELQKQMEESAPGEQGDPNAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ42</accession>
    <name>E8WZ42_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ordered locus">AciX9_2934</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2934"/>
    <dbReference type="EnsemblBacteria" id="ADW69957">
        <property type="protein sequence ID" value="ADW69957"/>
        <property type="gene ID" value="AciX9_2934"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2934"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_0"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="27206" checksum="771C542941BA6B67" modified="2011-04-05" version="1">MASVSETVDLDSTSKAQVEDGFQPGPVLLLGAPGVGKGTQAKILMGKFGIPQISTGDILRDHRARHTQLGLAADELMSKGQLVPDDLVNQMVEVRLAGTDCATGYILDGYPRTLAQANALDSFLQSDAGEPENATPVVAISIMVDQEGLLKRITGRRLCAQCKHIYNIYSNPPKVAGICDTDGSVLEQRKDDTEEIFEERMREFHTLTAPVIPHYRAQGRFLEINGDRSVGEVTESIEEALRMLRARVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC2</accession>
    <name>E8WZC2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580129.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1762"/>
    <dbReference type="EnsemblBacteria" id="ADW68810">
        <property type="protein sequence ID" value="ADW68810"/>
        <property type="gene ID" value="AciX9_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1762"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_2_0"/>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="22749" checksum="8C66E23165D9287E" modified="2011-04-05" version="1">MKKAEVLLAMQEIGLVPVLRAESVERALALAEAIAAGGVTCLEITMTVPGAMQVMRKLAETRPDILIGAGTVLDPETARMCILEGAQFVVSPALNLKTVEMCQRYSIAVLPGALTPTEIVTAWQAGADVVKVFPASAMGGASYLKSIKAPLPQVELIPTGGVSLATAEDFLKAGAFALGVGADLADAKSVAEGRPEVVTESARRYLGIVKTYRAKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE8</accession>
    <name>E8WZE8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP-like extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1788</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1788"/>
    <dbReference type="EnsemblBacteria" id="ADW68836">
        <property type="protein sequence ID" value="ADW68836"/>
        <property type="gene ID" value="AciX9_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1788"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133162_0_0_0"/>
    <dbReference type="OMA" id="PHHRENI"/>
    <dbReference type="OrthoDB" id="1705869at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="27237" checksum="EEA0E2D021417394" modified="2011-04-05" version="1">MLLSSSHSRFLVVLLLGLFAGGIALSQGRSVSEQYLLAAANQDRVANSLRPVRLDPLLSAAALVHAREMAAHRAISHRFPGEADLADRVANAGVPFSLVTENVAEASNSALVHELWMKSPGHRANLLDAQVDSIGIAVLAVQGQLYAVEDFARTVAVISFQEQEGRVGGLLEGSGVIVSSDPVDARRTCKMESGYSGTPQPWFVMRYTTATLARLPEQLAARLSTGKYRRAAVGACTPSKSTPFSSYSIAVMLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI4</accession>
    <name>E8WZI4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1825</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580191.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1825"/>
    <dbReference type="EnsemblBacteria" id="ADW68872">
        <property type="protein sequence ID" value="ADW68872"/>
        <property type="gene ID" value="AciX9_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1825"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643702_0_0_0"/>
    <dbReference type="OMA" id="PDQEWQA"/>
    <dbReference type="OrthoDB" id="1352245at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="464" mass="49348" checksum="2FDE86F7B8062B1A" modified="2011-04-05" version="1">MNLIKNTLGCPILGPQSHRGTGWGIVCGSKRPLALAAALLFTLPFAKAQDFSSTTTHTIQLPENPARAAAQAALEARDYPKALKLLTPLAAANPGDAHLQYDLGSVQDVLDQSSPAEASYRAAINADQAFLEPHLALGLLLARAGRFDDARPELVAATKATGENLLKARAFRTLARLDEKSRPADARDELLEALKLSPETPEDTLLTAELAQSAGNGAKPAEAAYRRLLAQHPNDPQATAALAHLLVQEKRPDEAEALLNQSLTANPGDPVLTAQLASLLTQQGKTAQALPLVEDLHKAHPDNPEITHLLASLETQSGNFAAAEPLYAALSNAAPNDGTLADAHADALIHLKRYAEAEKILTHAVTTPITYPTKEDLAASAGHLAFAASSNNDPQGCLQALQLRATVLPSSPTTLFLAAISLDKLHRIKQAQQAYKDFLAASNGSLPDQEFEAQHRLIALQHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI7</accession>
    <name>E8WZI7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEGA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1828</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1828"/>
    <dbReference type="EnsemblBacteria" id="ADW68875">
        <property type="protein sequence ID" value="ADW68875"/>
        <property type="gene ID" value="AciX9_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1828"/>
    <dbReference type="eggNOG" id="ENOG502ZCCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053531_0_0_0"/>
    <dbReference type="OMA" id="AGDAMNN"/>
    <dbReference type="OrthoDB" id="141437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="34464" checksum="BDD0C8157974B080" modified="2011-04-05" version="1">MFLSLRSDLAAADPGQNRTYCSLSGRVTTPEGTPVPEAIVQLSGPLLPPRTATSDADGRFTIVDLPPGTFSVTVSRDGFSPVTGSVRLVPEANTASATFTLRPAATDSVTVSASDKDIAEAQIHLAEQQRIAGILPNFFVSYIWRATPLTSGQKFRLALKNAADPGNLILVGTVAGVQQATNSFPGYSQGWKGYGRRYGADLGNLVSGTFIGGAILPSVFHQDPRYFYKGTGSTSSRFWYAVSRTVVTRGDKGRPQPNYSTMLGDMSAGALSNLYYAPEDRQGAKVTIANGLLGIAGDAMNNVFQEFVLKKLTTNNKRNTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI8</accession>
    <name>E8WZI8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-arabinofuranosidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1829</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580195.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1829"/>
    <dbReference type="EnsemblBacteria" id="ADW68876">
        <property type="protein sequence ID" value="ADW68876"/>
        <property type="gene ID" value="AciX9_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1829"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_1_0_0"/>
    <dbReference type="OMA" id="LYGFMFE"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234199" evidence="3">
        <location>
            <begin position="22"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="442"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="630" mass="69816" checksum="7429DDC718E5899D" modified="2011-04-05" version="1">MKIQYRLCLVTFCLVAPVLQAQTPTLTIDASKPVTAVSPTLYGLMTEEINYSYDGGLYAEMVRNRTFHDHWPPFEYWTVVAQKSATAQLKYGSTGPSAALSKSLQLTIVDAGPGNEAGISNPGYWGMAVQPSTTYKGSFYAKVDHPNVAHARLIADDSGNVLAQAAIVLPVGDWKQFQYVLHSQPNVTASSRNHLELTFEHPGIVNLQLVSLFSPTFNNTPNGNRPDLMKMMSAMSPKFLRLPGGNYLEGDYINERFEWKKTLGPLVDRPTHRGPWGYQSTDGMGLLEFLKWCEDLKIEPVLAVYAGYSLKGYHVQPGKDLEPFVLDALDEIEYVTGDPGTKWGAERAKEGHPKPFPLHYIEVGNEDWFDKSKSYDARFEQFASAIRQKYPAYKLIATAPVTQGQPDVIDDHYYLTPEEFFSPDQNQKYDKMDRKGPKIFIGEWATRTGSPTPDFGAALGDASWMTSMERNSDLIVMASYAPLLTNINPGGMQWSTDLIGYDSLRSYASPSYWAQVLFAAHLGDHTIRTSGSGLDPRFFWSATTSEKNHMLYLKLVNASAEPQAITLALNGVHSGSAQLSSLHAATRSATNSIERPNAIAPVQSRVNVVDGQWKHTIPGNSIEVLDIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ6</accession>
    <name>E8WZJ6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="7" type="ordered locus">AciX9_2947</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581285.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2947"/>
    <dbReference type="EnsemblBacteria" id="ADW69970">
        <property type="protein sequence ID" value="ADW69970"/>
        <property type="gene ID" value="AciX9_2947"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2947"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_3_1_0"/>
    <dbReference type="OMA" id="HARESEQ"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="10347" checksum="A217994426012C8D" modified="2011-04-05" version="1">MELEKIRTQSEEELKATQTTAAEQLFRLRFQKSLGNQEGIKKLRVLKLDIARAKTVLREREIEAEKKANPVVKNEAPAKSTRTERKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X020</accession>
    <name>E8X020_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist and glycosyl transferase</fullName>
            <ecNumber evidence="2">2.4.1.187</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.187" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580235.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1870"/>
    <dbReference type="EnsemblBacteria" id="ADW68916">
        <property type="protein sequence ID" value="ADW68916"/>
        <property type="gene ID" value="AciX9_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1870"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041635_0_0_0"/>
    <dbReference type="OMA" id="PWRWRRM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="303"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="401" mass="43514" checksum="0E885B195CD7DA00" modified="2011-04-05" version="1">MSNKAAKTVALFGLPITNVTMAEAVARVEENIASGRTHQIATANLDFARNSLKDVYLQRVICDCSMVLPDGAPMIWAAKLFGKPLQERVTGVDLIPELAKLSALRGYGIFFLGASEASSRKAAQVLERDYPGTHIVGRYSPPLQALHEMDDVEILRQIDLAKPHILLVAFGNPKQEIWIHRNRKRLKVPVAIGIGGAFDMIAGNLKRAPAWIQKLQLEWLYRLLQEPSRLLPRYAYDAAALIRHLPLGVAVSRLQPHSPLAEKIGVTVLGGVRVATAPETLSGDLCSLLTTEATAAAKEHQMLVIDLSATARIEADGLGCLLEARRTMMAAGLQVWLAGMSNPVKRVLQFSAMLDLFLLAPSLADAVRLASVGQSEVEWKAQMVDKGTRTPAGVHAGPVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X045</accession>
    <name>E8X045_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase (Class B)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1895</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580260.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1895"/>
    <dbReference type="EnsemblBacteria" id="ADW68941">
        <property type="protein sequence ID" value="ADW68941"/>
        <property type="gene ID" value="AciX9_1895"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1895"/>
    <dbReference type="eggNOG" id="COG2503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053338_3_0_0"/>
    <dbReference type="OMA" id="DEFMEVQ"/>
    <dbReference type="OrthoDB" id="1535353at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="30358" checksum="C1AC54B6FF9AAF5D" modified="2011-04-05" version="1">MRRVRRSLSFAAVVLVFVGGMWGQESAGPPACPVAKKLPVPLAPGQTFHPVEVARPSVEAARKTAEGGAVDPSVLVAAEPLENFGVARYRLKDYGDCVGNGGCYWSDVQAQAMRAKGALDMAVQGHKAGEKLALVLDIDETTLSSYCEMKREDFGYIPEMFNGWVVTPEAAVAVPGMMQVFEEARAKGVAVFFLTGRPEEQRAATERNLKAVGYSGWAGLVLRNAEEKGMPTVAYKAAERGKIVAAGYRIVMSVGDQWSDLNGEPRAEISVKLPNPFYYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R4</accession>
    <name>E8X0R4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein, HK97 gp10 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580334.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1969"/>
    <dbReference type="EnsemblBacteria" id="ADW69015">
        <property type="protein sequence ID" value="ADW69015"/>
        <property type="gene ID" value="AciX9_1969"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1969"/>
    <dbReference type="eggNOG" id="ENOG502ZWQE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608526_0_0_0"/>
    <dbReference type="OMA" id="NWVENGH"/>
    <dbReference type="OrthoDB" id="2167906at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010064">
        <property type="entry name" value="HK97-gp10_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04883">
        <property type="entry name" value="HK97-gp10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="17699" checksum="C3AFDF126B2B6B14" modified="2011-04-05" version="1">MADGFSADIKGIAEVKALFEALSTKEADNAILKALKAGALIEQAAISDRAPVKDTTGGLLPEGALKADIEVKVHRPSGRTPYVTVAPGKYTAHVARWLEYGHRLVRGGYSRMLKNGKTRGPGKEVGFVAEHSFIRVGYEESREAVVEAISNTLVAEIQKAAVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X9</accession>
    <name>E8X0X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581476.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3151"/>
    <dbReference type="EnsemblBacteria" id="ADW70163">
        <property type="protein sequence ID" value="ADW70163"/>
        <property type="gene ID" value="AciX9_3151"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3151"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_0_0_0"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="184"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="357" mass="37821" checksum="D757CDFACB154431" modified="2011-04-05" version="1">MKSWKIDRLGDKLSFVDVPIPEVRPGSVLVRVQSQALMSYLKPYVEGKLPAYRAPEDFTPGGNAIGTVEAVGADVWHLKKGQRVVTSSHLVARENVPEPGQVLIGVTSPGGIGDALQSSWKDGTLAEYVLLPAQVVTPINGLDHYDFPQLTAITRCIVPFGGLTRGRLQAGETVVVNGASGAYGSAATLVALAMGASRVVAAGRSKETLDKLAKAGGERVIPVVLTGDVTKDTEALRSAANGGAHLAFDQVGNAKDPNSTLAALGSLYRWGRIVLMGSSAVPIPINYLQMMFNNWEIIGNFMHPQGAYLPLLSLVRSGQLDLNPIQPRVFSLPDLEPAMEYAGKAGSLELTVVTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X111</accession>
    <name>E8X111_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0809</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579202.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0809"/>
    <dbReference type="EnsemblBacteria" id="ADW67877">
        <property type="protein sequence ID" value="ADW67877"/>
        <property type="gene ID" value="AciX9_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0809"/>
    <dbReference type="HOGENOM" id="CLU_2023447_0_0_0"/>
    <dbReference type="OrthoDB" id="2219995at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13157" checksum="B29785E1E8E4686D" modified="2011-04-05" version="1">MTTKKIANVADHAKPKIKLKARLKTESQPASTSLYHGLNMVLHAVRSIAQYEDALCELAHEAKGSEALSAGANETLRGILAKIPSDEYLRELDVVRALVGSDPKAAPRKKVQVKKAGRASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X112</accession>
    <name>E8X112_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase IV</fullName>
            <shortName evidence="12">Pol IV</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dinB</name>
        <name evidence="14" type="ordered locus">AciX9_0810</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579203.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0810"/>
    <dbReference type="EnsemblBacteria" id="ADW67878">
        <property type="protein sequence ID" value="ADW67878"/>
        <property type="gene ID" value="AciX9_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0810"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_0"/>
    <dbReference type="OMA" id="CKPDGLL"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="12">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="368" mass="41113" checksum="EA3910CBAB6043B8" modified="2011-04-05" version="1">MEIEQVSAERREGGSGRKIVHVDMDAFYASVEQRDDAGLRGRPVVVAWKGRRSVVCAASYEARRFGVRSAMPAVTAERLCPEAIFVPPDFTRYKAVSRAVREIFERHTDLVEPLSLDEAYLDVTENKLGLATATRVAKMIREQIREELNLTASAGVAPNKFLAKIASDWKKPDGLFVIQPHEVQGFLMPLPVGRIPGVGKVTEERMKSVGIATVGDLHAMDHPTLEQHFGRYGRRLYELARGVDENPVVANRSSKSLSAEDTFEKDIPLAETEPLVRRLAEKVWLASRQNARMARTVVLKLKTKEFSTLTRSLTPLAMPTSAEMLGDVAVFLCSRVEFGPEQLFRLVGVGLSTSRWRRRRGRRCLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X133</accession>
    <name>E8X133_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0831</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67899">
        <property type="protein sequence ID" value="ADW67899"/>
        <property type="gene ID" value="AciX9_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0831"/>
    <dbReference type="eggNOG" id="ENOG502ZMAI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153233_1_0_0"/>
    <dbReference type="OMA" id="LACQKCQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10435" checksum="2D261FA6BBAF94AD" modified="2011-04-05" version="1">MPKLRTYPTKWPSILLACRKCQKKLKGTDLSRLKKLLKSQAKQTGTPPPHLIPVSCLKLCPKGGVAVCTQSGLTQTPPQLSILYSPQDLLALIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X162</accession>
    <name>E8X162_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0860</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579253.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0860"/>
    <dbReference type="EnsemblBacteria" id="ADW67928">
        <property type="protein sequence ID" value="ADW67928"/>
        <property type="gene ID" value="AciX9_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0860"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_0"/>
    <dbReference type="OMA" id="FLEYEHG"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="518" mass="58006" checksum="36CDB06207C3B589" modified="2011-04-05" version="1">MKKDSRQVVIVGAGPGGLAAALLLAKSGVKVTVVEKRADVGGRTSTIHQDGFKFDVGPTFFLYPRVLKEIFAAAGYDLDREVAMTRLDPQYRLVFGAGGELLATPNVERMEKAIEAISPEDAKRFHQFITHNRNKLEKFLPFLQSPFESWRDLAKPEMLKLLPLLAPWRSLDSDLQVHFKDERIRLGFSFQSKYLGMSPFRCPSLFSILSFLEYEHGVFHPTGGCGAITQAMARIARELGVEILLDEPVEEVLIEGGKATGVKTANHMLKADAVVVNADFAGAMRRLVPNAKRNKWTNERLAKKKFSCSTFMMYLGIDGQFDDVSHHTIYLAENYRENLKDIEERHALSENPSFYVQNACVTDKTLAPEGQSTLYVLLPVTHDTGSVDWAKEQPRYREIALRQMERIGIKGLESRIRTEKIVTPAGWSEEFDLYKGATFSMAHSLDQMLHLRPHNRFEDVEQMYLVGGGTHPGSGLPVIFESARITSRLLLEDLKMEPQWQAGSAEETVTGELVGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X176</accession>
    <name>E8X176_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1984</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1984"/>
    <dbReference type="EnsemblBacteria" id="ADW69030">
        <property type="protein sequence ID" value="ADW69030"/>
        <property type="gene ID" value="AciX9_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1984"/>
    <dbReference type="HOGENOM" id="CLU_3234228_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="43" mass="4720" checksum="91760FEE1A83862A" modified="2011-04-05" version="1">MVNVILQGREAIKLNKDKGFAAICKIMLDTAICGKWDLKSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G2</accession>
    <name>E8X1G2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3186</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581509.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3186"/>
    <dbReference type="EnsemblBacteria" id="ADW70197">
        <property type="protein sequence ID" value="ADW70197"/>
        <property type="gene ID" value="AciX9_3186"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3186"/>
    <dbReference type="HOGENOM" id="CLU_2806443_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="6997" checksum="D5A9DB22BADA10EB" modified="2011-04-05" version="1">MKLARSYQLLAVGIAVCLGGTLFVGMGGASSLARAGEASLEFVGNLIESGHELALSERLDPTYPHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L3</accession>
    <name>E8X1L3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3237</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581560.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3237"/>
    <dbReference type="EnsemblBacteria" id="ADW70248">
        <property type="protein sequence ID" value="ADW70248"/>
        <property type="gene ID" value="AciX9_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3237"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168989_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="11313" checksum="F4CA76CA53460261" modified="2011-04-05" version="1">MKITEVTEQIEAVHDDLTGSSFIDVNLASATFSNVNLACADFESACLNDVKLHNVTCLRMQIYDADLSGVTIAESNTETMTIDGITVAALMAAYRKCGPNPTPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R0</accession>
    <name>E8X1R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0912</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579303.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0912"/>
    <dbReference type="EnsemblBacteria" id="ADW67979">
        <property type="protein sequence ID" value="ADW67979"/>
        <property type="gene ID" value="AciX9_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0912"/>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105851_4_1_0"/>
    <dbReference type="OMA" id="FWVGDKA"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16687" checksum="7A66FB96B14324C9" modified="2011-04-05" version="1">MNAERARTFLLGLPNVVETAQWGGLVFWVGDKAIGGKMFAMMNPEGVVPMQHPMTVPVGAERFAELMEVEGFVPAPYLARLKWVSAERWDAFRDREWEEAFVAAHAITFEKMPPKVKTVLAMSKAAQKRLITERRKVLAEKSKAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G7</accession>
    <name>E8X2G7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580507.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2147"/>
    <dbReference type="EnsemblBacteria" id="ADW69191">
        <property type="protein sequence ID" value="ADW69191"/>
        <property type="gene ID" value="AciX9_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2147"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459363_0_0_0"/>
    <dbReference type="OMA" id="KEQVIHI"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="20614" checksum="2C6271D47EB84724" modified="2011-04-05" version="1">MATATQTPYLSVEEYLRTSFRPDVDYVDGHIEERNLGEWDHSTIQYVFVRIFDRHRKDWQIRMRNEIRTQTGTRNYRVPDVCVTDARYPKEQVIHIPPLLCVEVLSPEDNFREMRERITDFLSMGVPQVWIVDPKRRTATVCTSAAKDTVHCTGILTVPDTLIAVDLEEVFAALDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N1</accession>
    <name>E8X2N1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3317</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3317"/>
    <dbReference type="EnsemblBacteria" id="ADW70328">
        <property type="protein sequence ID" value="ADW70328"/>
        <property type="gene ID" value="AciX9_3317"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3317"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_0"/>
    <dbReference type="OMA" id="FQLNTVI"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="77"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="193"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="390" mass="44777" checksum="EA5F383BA1FE20BF" modified="2011-04-05" version="1">MKRKRRYQQGTLSKSKTAEGICWFIRFVDTTPGNPKRPRLPVGLLAKYPTEASASRAAQVIRDQFNDSPDPLLADRRTFGDLIDRYLLEEIPERHSTRRGYEKLIRCHIRPRWGEVPIASVKAQEVRTWLRELAVTRKKGDVPISSPASGRYKGHVHNMMRLLFRFGMLWEWVPNQTNPMSLFSLEGSTKREEQPGNLTEAQFHLILAKIVDPGFRVMVMAAMCLGLRVSELLALKWEDFDFELELVRIQRAVVEGKVGNVKTIHSKKPLPLDPLLAGAFRTWRAASQFNEDDDWVFPTAAGERPYAASAIQTRVLIPVGKAIGLEFSLGWHTFRHSYKTWMDIKQVPMTVQRDLMRHADVRTTMQVYGDVRMEELRGANSDVVRRVIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P1</accession>
    <name>E8X2P1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3329</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3329"/>
    <dbReference type="EnsemblBacteria" id="ADW70338">
        <property type="protein sequence ID" value="ADW70338"/>
        <property type="gene ID" value="AciX9_3329"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3329"/>
    <dbReference type="HOGENOM" id="CLU_1308669_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="23868" checksum="F0D568EB7A20AA4B" modified="2011-04-05" version="1">MTSENDTLTSTKIISSSAGQRLCVPPPEQHSTHLVTFLNEKSPRNIESIQRITNLISAIGEAESKHRAQIEEGPKDFWKTQTLDDLAPFHRVDSLLSSYLRVPVIHKGIALDGTTFVDIRMMLGNQDLPIAEQYAASQVINLVQTKKFSFLQKCTCGEWFVALRSDQKTCSKRCRLKSYVRSEDYKAKHRDLMKRRYQSKKEEVPPGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X6</accession>
    <name>E8X2X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1047</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1047"/>
    <dbReference type="EnsemblBacteria" id="ADW68110">
        <property type="protein sequence ID" value="ADW68110"/>
        <property type="gene ID" value="AciX9_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1047"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_1_0"/>
    <dbReference type="OMA" id="PLVWNRA"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46836" checksum="BF8213ED0458A8F7" modified="2011-04-05" version="1">MGAGRLCWRSRSAKSIGEMNMGCKWWVLGVMACVVAGAEVPDKRAAQETAAMAATVRAEWPNGIITTLKSPGAWTYEEGVVLDGMAAEWRQSKDAKDFAYIKAAVDKYVSADGVIHVNPSGAVFETGGHTLDNIEMGRAVLMVYRTTHELRYQRAAEFLHEQLAVQPRTASGGYWHKQIYPNQMWLDGAYMAEPFRAEYAATFGIEHEFGDIAKQFLLMDEHMRDPKTGLPRHGWDESKKMPWADPQTGLSPEVWARALGWYAMALVDTLEWFPEDHPKRAALVADLNRTMAAVVKYQDESGTWWQVMDKGGAKGNFAEASASCMFVYALERGVRKGYLPAKPYEAAALKGWQGIQKAFVRPEADGHVVLTTTVKAAGLGGKPYRSGTYEYYVGEAVGDNDAKGVGAYLLAGSEMRHARAEMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X8</accession>
    <name>E8X2X8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1049</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579435.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1049"/>
    <dbReference type="EnsemblBacteria" id="ADW68112">
        <property type="protein sequence ID" value="ADW68112"/>
        <property type="gene ID" value="AciX9_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1049"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="DIQMVAQ"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13363" checksum="F03FBE5A1480AFC9" modified="2011-04-05" version="1">MRRVLIIDDEDDIREVAALSLEATANWTILTASSGREGMAVAAAEKPDAILMDVMMPGMDGPTTFKQLQLNPLTARIPVVLLTAKVQGVDQRRFAGLGVAAVLFKPFDPLTLAAQISEALGWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z8</accession>
    <name>E8X2Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1069</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1069"/>
    <dbReference type="EnsemblBacteria" id="ADW68132">
        <property type="protein sequence ID" value="ADW68132"/>
        <property type="gene ID" value="AciX9_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1069"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="FNGDARD"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="25921" checksum="0BD9FB72FF4B7D86" modified="2011-04-05" version="1">MLVAMQRTALVTGASRGLGAAMAIALAEAGFAVAVNYMTSEGRAVELCRSLTGRGLRAAAFQGDVRAEGDVARLVSEVTGALGPVDVLVVNATGHQPMLSIEEQTWQDYLDQMEFFVKSPLLLVQAVLGGMRERGFGRVIQIGSEVVELGNPRFANYVAAKAAQLGQTRSWARELGASGITVNLVAPGWIPTERSVDATAGEMAAYVAGVPLGRMGDAAEVGRVVAFLAGDGAGFVTGQKIAVNGGRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X326</accession>
    <name>E8X326_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2206</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580566.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2206"/>
    <dbReference type="EnsemblBacteria" id="ADW69250">
        <property type="protein sequence ID" value="ADW69250"/>
        <property type="gene ID" value="AciX9_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2206"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_0"/>
    <dbReference type="OMA" id="VSGHKGM"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="36782" checksum="11A407AC2A1B701E" modified="2011-04-05" version="1">MAIDAVELTRQLVGIESTTYHEYPAGVFLHELLEGMGWAVERQEVPKPAVGTPGAECGGERFNVYAGMTGEIADVVLSTHMDTVPPYVPLREDEEYLYGRGTCDAKGIIAAQVAAAERLRELGVKVGMLFVVGEERDSAGAAVANGLAKGSRFLINGEPTDSRLALASKGALRVELYAKGKMAHSAYPELGESAIDKLIEALHDIQALPLPYVEGIGESTANVGLISGGRAPNVIADAAEAHMLIRLVGPAEETKAAIVKAVDGRCVVDFSLELPFVRMRKVGNLPTMVAKFTTDIPSLTNWGEPFLLGPGSIHVAHTPDEKISKKELVDAVGLYVELALELVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X333</accession>
    <name>E8X333_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2214</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580573.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2214"/>
    <dbReference type="EnsemblBacteria" id="ADW69257">
        <property type="protein sequence ID" value="ADW69257"/>
        <property type="gene ID" value="AciX9_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2214"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_4_2_0"/>
    <dbReference type="OMA" id="WTADLWD"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="35732" checksum="5031B0D299C89C19" modified="2011-04-05" version="1">MEQQASTPKCCCTPRTSRVPESAPNNPAPLLNGPPPSPDASRIISLPGGEFLMGTDYEEAFAADGERPVRRVHLKPFQIDIYPVTNADFAAFVQATHYKTEAELYGWSFVFMNHIPKLQRGSLVTDTVAGAEWWCQVPGAVWNAPEGPGSDVARRSDHPVVHVTWNDALAYCDWSGNRLPTEAEWEYAARGGLVQKLYPWGNQLRPNGEHRCNIWQGTFPHEDTAEDGYAGTSPVKAYPPNGFGLYSITGNAWEWCMDWFGIPDSVDTVTEDPVGPPTGTVRVMKGGSFLCHKSYCNRYRVAARSSNTPDSSTSNLGFRCARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X350</accession>
    <name>E8X350_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580590.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2232"/>
    <dbReference type="EnsemblBacteria" id="ADW69274">
        <property type="protein sequence ID" value="ADW69274"/>
        <property type="gene ID" value="AciX9_2232"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2232"/>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173195_0_0_0"/>
    <dbReference type="OrthoDB" id="1944332at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12403" checksum="6166A69878101949" modified="2011-04-05" version="1">MPTQSRKAVLSKFPLRLMPSVRSTAEQFSQKEGVSLNQFINVAVAEKLAHLQHEEWARNRAKPTQETYDQIMHFADGLPDVPPQPGDELPAGYVPIHQRTEGGSKRKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X351</accession>
    <name>E8X351_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2233</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580591.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2233"/>
    <dbReference type="EnsemblBacteria" id="ADW69275">
        <property type="protein sequence ID" value="ADW69275"/>
        <property type="gene ID" value="AciX9_2233"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2233"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_2_0_0"/>
    <dbReference type="OMA" id="RDANDEM"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="15811" checksum="A8B82BFFE896D086" modified="2011-04-05" version="1">MRIVLDTSCFITAIRSVHGAAAEVIRVIAARRVTILMDYKLSCEYRDVALRPSNLLASQISSQAMQKVISNLEDVAEAVQISVKHRPLSPDPDDDMILDLEINGHADAIITQNRKHFVQAAEVFGIPVLSPGELLHHLRYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I2</accession>
    <name>E8X3I2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ordered locus">AciX9_1110</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579496.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1110"/>
    <dbReference type="EnsemblBacteria" id="ADW68173">
        <property type="protein sequence ID" value="ADW68173"/>
        <property type="gene ID" value="AciX9_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1110"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_0"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="356"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="494" mass="55631" checksum="4F47B4C35AB53E60" modified="2011-04-05" version="1">MTDTLIASAPTRVRIAPSPTGDPHVGTAYIGLLNYIYARQRGGQFVLRIEDTDRARFVATSEQEIFDSLHWLGLEWNEGPDVGGPYGPYRQSERTEIYREHVELLLANGTAYKAYENAEELEAMRKSQLAAKLPPRYNGAHRELTAEQIAAFEAEGRAYVVRLKVPVEGETAFRDELRGEIKFSHNNVDDQVLMKSDGFPTYHLANVVDDHLMKITDVIRAEEWISSTPKHVLLYQAFGWELPKFWHMPLLRNLDKSKISKRKNPVSLIYYRQAGFLPAAVLNFLGLMGGGMPAGTDKAVQAEIFTLPKMLDEFKFDRIALGGPVFDLVKLKWLNGEYLRALPGEEFFLQLKNVVFSDEVLRAIAPLVQTRIETLGQFGDLADFFFRDDVTPAQEVFVPKKRTLEETMAFTGEMLAVLEGCEWSHDALDAALRGVGTAKEWSVKESFMLLRAILTGSTSSPPLLESLVVFGKARSLDRVRRFVDGQKKIAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I9</accession>
    <name>E8X3I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1117</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579503.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1117"/>
    <dbReference type="EnsemblBacteria" id="ADW68180">
        <property type="protein sequence ID" value="ADW68180"/>
        <property type="gene ID" value="AciX9_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1117"/>
    <dbReference type="eggNOG" id="COG3481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056349_2_0_0"/>
    <dbReference type="OMA" id="NLVGHLV"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="160"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="38699" checksum="83B3AC9C087E7210" modified="2011-04-05" version="1">MKDFYVKDAARFDNTAVTTYFCLNQIQVRDRKGGGQYLALTLSDKTGTLEARMWEDFAEAFQTCGEGCYVKVQGQISKYQGKFQITLTKLRNAAENEIEAADFQPVSAFPAADMDAELRGYIAAFKDRDLQRLILAFLDDPEIGPAFRIAPAAKLLHHAWISGLLEHVLCLVRVCLANAPFYPVNPDLLVTGAILHDIGKIRELSWKTSFNYTLEGQMIGHISIAQGMLREKVQQLAPFPEKLRILVEHMILSHHGKYEYGSPKLPMTPEAMLLSALDDLEAKFAATHREFAAAEDAGKRPDELTDWVRSMERPLLNSARWLADGVAQEEPEPTQQPEPTTLFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J5</accession>
    <name>E8X3J5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1123</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1123"/>
    <dbReference type="EnsemblBacteria" id="ADW68186">
        <property type="protein sequence ID" value="ADW68186"/>
        <property type="gene ID" value="AciX9_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1123"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="GARDTYQ"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="188"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="572"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1227" mass="131740" checksum="2E72391620823EE3" modified="2011-04-05" version="1">MHPGYEPWHPFFLREDNAMIISRSQRGFFSELGRVAPQPRRRNPLYVCLESFVKRSLASAATVCFLALSIAPLSAQFETASVLGYVHDSSGAALAGANVTLVNVATKVTVTVKTDAQGAYQFTDVKIGQYEVDADAQGFSNGATAPFAVQVNARQRVDVSLKIGSAADAVTVTDSAALLETESNERGQVIGTREVENLPLNGRAYADLAALVPGVRRNLLENSSDSSRDATFNVNGQRSEFNNFLLDGLDNNAYGTSNQGFSNQSIPPSPDAISEFKVQTDNYSAEYGRSAGAVINVSIRSGSNAFHGKAYDYIRNTVFNAIGPFTPPTNPLTSAAQKPILIRNQFGATLGGPLRKDKLFFFGDYEGTRQITHNINQATVPTANQNGTSALAVSNGGYTFLSAVNGADAGNPVSIRNPLTGQVYANGVIPFSDPSISPFAKGILGALPNANVAGSPVANNYASLPAGTLDDNKGDARVDGVFGAKTTAFVRYSQHQGNILSPPVIQGAAGGNSNGFVKIFNQQIAGGVTHTFTQNSILDARFAFTRTDGGKSPYGGNLPSLETGIPGLPTNPLTVRSLNVQSVANYSQFGNLGSNPQFQNPYVFDPKINYTWIHGRSTYKAGYEYQSIFTTINDFNPSFGQDTYNGNFSYNGASASALSASDTGTKEAASLSDFIFGARDTYQLNNFVIVNLNQRMHYLYLQDDIRVSSKLTINAGLRYELVTPQWESNNLLANFDPGTNSLIKATSGSIYNRALVNMPKLDFAPRFGLAYSVDNKTVIRAGYGLGYAQFNREGGENLLVYNLPAVVNTNIVQAPINANPGVTGSQARLAVCNATQVTAVYDPTNPTPCFRTSTQGYPTNLANPANVTAASNLNTQARYLPKNLPTGYVQSYHLTVQRQLGPSTSLEVAYVGEHGVKLQVLADYNQAPSNPVTATCNASGLPGSTGGCLTVAQRRPVQSFTTIEETLPQGFLSYNALQTKFEHRTGHGLYVLNSFTWSRALDNASGHLDTNSGDNSRINLANSLGERGVSGYNQPLSETLSIVYDLPYGKGRSFGANAPFAMQELLGGWQLTLINDINSGLPINVIYSPNSAQQVSTILNVRPNQNGPALLPKSQRTKTAGNQGLNVFNLASFSLPTVNQTYGNEGRNSVRLDPFYQTDLGLHKQFAVYRDRVNFDFRAEAFNVFNKVNYATPSSTTYSPGSTSFGVLTSAGTFPARILQFAGKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J9</accession>
    <name>E8X3J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonyl and alanyl tRNA synthetase/DHHA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1127</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579513.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1127"/>
    <dbReference type="EnsemblBacteria" id="ADW68190">
        <property type="protein sequence ID" value="ADW68190"/>
        <property type="gene ID" value="AciX9_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1127"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2537835_0_0_0"/>
    <dbReference type="OMA" id="TLWHNTE"/>
    <dbReference type="OrthoDB" id="2060155at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="8886" checksum="1C067226A187FD65" modified="2011-04-05" version="1">MTFNSVVTDIRLESRTGLVGTWLMSLDHTEFLPGSTGILEAVTRSGTRLEIPVTSVITDDDGVTWHVVEKPLAAGTDVTGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q9</accession>
    <name>E8X3Q9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580653.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2300"/>
    <dbReference type="EnsemblBacteria" id="ADW69337">
        <property type="protein sequence ID" value="ADW69337"/>
        <property type="gene ID" value="AciX9_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2300"/>
    <dbReference type="eggNOG" id="ENOG5032PYG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739627_0_0_0"/>
    <dbReference type="OMA" id="SMIAMAR"/>
    <dbReference type="OrthoDB" id="1796361at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234139" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="16000" checksum="AC31971C33967445" modified="2011-04-05" version="1">MNKGLLLGAALGLSLACSMPGAAQEKGIWRAASKTAKSITGDVAFGDERISIYFSGYAIAQIRPLTPVEIGAAFDSDSTAGGSGNLYRLSIPGTKKFMHGTTMCGGEETQWLATYSVGKSLQMSFFSGATMPVFTPEALGSSTNLCGTYSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U4</accession>
    <name>E8X3U4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Polynucleotide phosphorylase</fullName>
            <shortName evidence="5">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pnp</name>
        <name evidence="8" type="ordered locus">AciX9_2335</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580688.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2335"/>
    <dbReference type="EnsemblBacteria" id="ADW69372">
        <property type="protein sequence ID" value="ADW69372"/>
        <property type="gene ID" value="AciX9_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2335"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_0"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="622"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="817" mass="87728" checksum="3267A397FEDE1AE3" modified="2011-04-05" version="1">MKHDVTVELAGGKHIKFETGRMAKQASGAAFTTSGDNAILATAVASPDPKEGIDFFPLTVEYREFTYAGGRIPGGFIKREGRPSEKEILTSRQIDRPIRPLFPEAFRNETQVVAFVYSADKENDPDVLGINGASCALALSDIPFHGPVGAVRVGLIEGNFIVNPTYAEREKSELNIMVVGTADGIVMVESGSKETSEESVVSAIEFAHVEIKKICAAIEELVKLAGKTKRTVTPVEVDQEYLGSLKAKVGERLSDALDTQKHPKFESYALVKTIKDELKKDLPEGDAAAGKKLSKYYELMRESIFRDQVLNDRIRPDHRAFDQIRLVTVETGVLPRVHGSALFTRGETQALVSATLGTTDDAQRMESYTGEFKRRFMLHYNFPPFSVGEVGRMTGVGRREIGHGALAWRAIEAVLPGEDESPYTLRVVSDILESNGSSSMATVCGASLALMAAGIPLKGAVAGVAMGLVKEGDKYAILTDIAGAEDHYGDMDFKVAGTRKGITALQMDIKIMGITPQIMREALEQARRGRLELLDTMDATISSASEQKSAFAPRIHSMQIPTDKIRDLIGPGGKVIRGIIDATGVKIDVDDTGRVNVASSDADGLSRAIQMITDLTATPEIGKTYLGRVVRLAEFGAFVEIFPGTDGLLHVSEIAEHRVKEVKDELREGDQILVKVLAIEGNRIKLSRKAVLREQRAKLGLPEVPEAGEGQRSAPRPAQAQTQAPEPGNIAEDGDDFDDDDDDDVEDGPDTNGEDEAEPNFNRADGVAPAAPAGGRPAGGPGGDRRPGTRRRRGGRRPGQGGGGGNAGGGGNRPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U7</accession>
    <name>E8X3U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2338</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580691.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2338"/>
    <dbReference type="EnsemblBacteria" id="ADW69375">
        <property type="protein sequence ID" value="ADW69375"/>
        <property type="gene ID" value="AciX9_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2338"/>
    <dbReference type="eggNOG" id="ENOG5033EN7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2633478_0_0_0"/>
    <dbReference type="OMA" id="THIGFLE"/>
    <dbReference type="OrthoDB" id="2036409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="9305" checksum="869E0F87426C853C" modified="2011-04-05" version="1">MFKGLVSLVGFLWVATKGSRLRPWRSEYLRWRVETYSGKTAGSLRIRDFLGLFFSERRQMTRFVRWMGEVRGLAEGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V7</accession>
    <name>E8X3V7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2348</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580701.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2348"/>
    <dbReference type="EnsemblBacteria" id="ADW69385">
        <property type="protein sequence ID" value="ADW69385"/>
        <property type="gene ID" value="AciX9_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2348"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_0_0"/>
    <dbReference type="OMA" id="NLYFAIQ"/>
    <dbReference type="OrthoDB" id="947161at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="251" mass="25480" checksum="24B858391D6EEC11" modified="2011-04-05" version="1">MDSGLYAAYTGLLARTQALDTAANNLANASTNGFRAQRDSFSGVLASGLAAGQQGSQVGVGINSYGVLGGSSADQSQGPMVTTSNPLDVAINGTGFFAIRTAHGVRYTRDGAFTLSAQGQLQTGAGEPVLNTAMAPITLPSGEVQISGDGTVAVQTAAGSGVVGQLGIFDFASTAGLTQEGANRFKAPDDAVPTASTAMVKQGAVEGANQDSVHGTMQLVLIQRQAEMMQKALSVFNADFDKTATEQIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z4</accession>
    <name>E8X3Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3497</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581813.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3497"/>
    <dbReference type="EnsemblBacteria" id="ADW70502">
        <property type="protein sequence ID" value="ADW70502"/>
        <property type="gene ID" value="AciX9_3497"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3497"/>
    <dbReference type="eggNOG" id="COG3041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161929_4_1_0"/>
    <dbReference type="OMA" id="DHRECHV"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="10761" checksum="E1BC5C3FAF6BF0AD" modified="2011-04-05" version="1">MLEVVMATRFRRDTKLMERRGLKMTKLREVIMLLAQEIELPVRYHDHLLSGSWKDHRECHVEPDWLLIYQLQEGQILFARTGTHADLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X423</accession>
    <name>E8X423_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3526</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581842.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3526"/>
    <dbReference type="MEROPS" id="S13.002"/>
    <dbReference type="EnsemblBacteria" id="ADW70531">
        <property type="protein sequence ID" value="ADW70531"/>
        <property type="gene ID" value="AciX9_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3526"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_1_2_0"/>
    <dbReference type="OMA" id="DGTMRKR"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230212" evidence="2">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="524" mass="55220" checksum="D777A20ADF23A488" modified="2011-04-05" version="1">MPARAVALLFTLATIAHAQAPLCDRIRALTQDPTVAAAHWGVQVATLDGTPLCGVNEAQLFRPASNAKIFTTAAALALLGPNATVETEVLSHGVFTGKEHLDGSLYLFGNGDANLSGRRVPYAPGTDEALPPLHSLDDLAAQVARTGLRSVTGDVIAIGDHFGNEPYPNGWSQDDILWGYGAPVSALDINDNEIKLTITPATELSSRATIEMTPALRYYTLSNDVMTTDTGSATSIAIERTPGSRLLHLYGHIALKASPETDHVAIEDPPAYAAMALKQALERQGILIDGHAIAEHVTSQDPRGFREVSRQPLDLPAMMSLGRGVASGLSPCPDPCDPAKISTNTLLGSLTSSTLLEDVILTNKSSINLHAEILLRRLGDRISLPGTFAEGARVVRQFLIDRGISADDVTLYDGSGLSTYDLVTPRSIIKLLAYGAAQPWGPAWKSSFPVGGVDGTLSARFTGPLKGRVFAKTGTLGESRALSGYLIAASGKTLIFSILVDNHLPGSADRVAMDKIVAAIAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X443</accession>
    <name>E8X443_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0012"/>
    <dbReference type="EnsemblBacteria" id="ADW67103">
        <property type="protein sequence ID" value="ADW67103"/>
        <property type="gene ID" value="AciX9_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0012"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038460_0_0_0"/>
    <dbReference type="OMA" id="FDPFHDP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233648" description="Metallophos domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="34"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="486" mass="51764" checksum="2A04E9920AD13F48" modified="2011-04-05" version="1">MFKRYVLGCLVMMLGVGSAGAQASAANAKVATVPVVMLSDLHFDPFHDPVKVPLLVKAPLEEWDRILGGPDSAGQAAAFAAIQTQCKAKENPDSSYALLRSALLAAKAQTPSVGFVMVSGDLLVHDLDCRYPASMKLEASAGDDQAVSAAFAEKTTVYVMKKVEATFAAVPVYLALGNNDSRCNHNRLSLHDEYLKASAAAVVDGLRGVSAAEKTAAMGTYESAGYYAVTMPGVMSGTRLLVVDDIYMMPKYANCEADDQDQQGAQEQMVWLQKELEDARTKGMSVWLLGHLPPAVNPDSSLEKGDSFCTKGKVVRYQTTDDLATEMTAYADVLKLGVFGHTHMDELHLLRGKDAGVPVKVVGSVSPVDGNVPSFTVGLVATASAKLMDYSVYEASNSTGVGTTWPKEYGFDETYHEPSFSAEPLSDLIGRLRADTSGKGEESRAYQTHFIKGSSGKKLSGSWPGYVCGLDNATAKGFKACVCGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D5</accession>
    <name>E8X4D5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1199</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1199"/>
    <dbReference type="EnsemblBacteria" id="ADW68262">
        <property type="protein sequence ID" value="ADW68262"/>
        <property type="gene ID" value="AciX9_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1199"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007251_1_0_0"/>
    <dbReference type="OMA" id="GYYERVL"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233656" evidence="2">
        <location>
            <begin position="26"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="690" mass="75637" checksum="4B81162D6ABEA181" modified="2011-04-05" version="1">MTLRSSAKHIVPVAALLLAAHAVMAQVKPAPVVPPAITDRSSAYYHDGLAHLYEEMAINNGRPDYATQAIEEYKLALNADPNSKYLQDGLADLYFKIGRIREAVTTAQEQVKKDSTDLSAHLLLGKVYLRSLNDMQGPQATEMLQLAIGEYEKIAQLQPKDLETHLILGQLYGLNHDSVKAEAEFKTAREIDSNSEEAVLSIARLYMEEGQPQRAVDVLGGIPADDRGSRTSAALGAAYDQLHKPKDAAKAYQESLDQEPDNVDTERALAAALLLDNQLDPALTVLKQIVAADPTDVQSTIHISEIQRRQGHYDEALVTLDKAKSLNTNSDNLELVFNEAVLYDSLGKYDQAIQTLQGVLASTKKTDGKYSEPEKSNRAIFLDRLGIVYGEESKTPEAITAYKEMVSMGGDYAIRGYQREIDTYRDAHQWKDAVAVGAEASAALPNDKSIQLTYAFQLADTGQVEKGLALANAQLKGGADDRDTLVAIANIDLRLKRSDDAMKQLDKAEALSAKPDDKAYVYLLRATVLDHDKHYDEAEAEYKKVLAIDPNNATVLNDLGYMQAERGIALPDALAMIQKAVTLDPQNGAFLDSLGWVQFKMGQYGPAETNLKKAIDRTASDPSIHDHLGQLYEKTGHLQQAVAQWERSMTEYARSLPADADPADVAKVKHNLEQARTKLARVGGAANKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F2</accession>
    <name>E8X4F2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1216"/>
    <dbReference type="EnsemblBacteria" id="ADW68279">
        <property type="protein sequence ID" value="ADW68279"/>
        <property type="gene ID" value="AciX9_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1216"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_1_0"/>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="27873" checksum="167579C582BBFC9F" modified="2011-04-05" version="1">MHDRNNAPAESECRTEAQLRQELVRFGKWVHRLGFTPGTSGNLSVRLDRQRLLVTPTGVSKCLLKPADMVIVDLRGRLLEGTRKVTSEIGMHLAVYDQRPDVQAVIHSHPPIATAFACAGRALSEMLCQEAVMTLGIVPLARYATTGTCEVAESLAPYLPAHDAILLANHGAVSYGLTLLEAFQKMETLEHLAQVSLVAHQLGTAQPLTAQQIEQLHLARSKYLHNAAQTNEPDSLPHRTQQHETELFVVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X500</accession>
    <name>E8X500_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0114</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0114"/>
    <dbReference type="EnsemblBacteria" id="ADW67192">
        <property type="protein sequence ID" value="ADW67192"/>
        <property type="gene ID" value="AciX9_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0114"/>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042829_3_0_0"/>
    <dbReference type="OMA" id="FWPVLHL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23869" checksum="5412023BB93DBE15" modified="2011-04-05" version="1">MAKPIGTADWTWKGIWRFCINAENLAVVRHATAPTLRLSDLLRRNLDVVFCGINPALSAARAGHHFSSHSNRFWRVLHLAGFTPHVIKPENDRTILQFGCGLTAAVERPTVRASELSGHEFHEAATALERTLRHYQPRYVAFLGKPAFAAIFRQRRVDWGPQAMRFSGAHVWVLPNPSGLNRAFNLEALVTFYRELRTASRQLDSSDGSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X528</accession>
    <name>E8X528_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FkbH like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0145</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578548.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0145"/>
    <dbReference type="EnsemblBacteria" id="ADW67220">
        <property type="protein sequence ID" value="ADW67220"/>
        <property type="gene ID" value="AciX9_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0145"/>
    <dbReference type="eggNOG" id="COG3882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018095_1_1_0"/>
    <dbReference type="OrthoDB" id="1310135at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="599" mass="67802" checksum="78D02BF1B03C56DC" modified="2011-04-05" version="1">MLDFDFCSIDDILRNRKSIRRELSASDGLRELRIAVLGGSTTNEFVNLLEILLLASHFRPVFYQSEYGRFYEDAVYDPQTLIDFKPDLVYIHTSNRNIQNYPPLNCSEEQLAGCVASELERFQEIWSALDANVHCQIVQNNFEVSAYSFLGSLDASSSGGRGRFLSELNVAFAKAIAERSNTILQDIHSISAHVGLKRWFDWSRYFSYKLLYTAEANLEIARSLNAIVKAIYGKKRKVLVLDLDNTLWGGVIGDDGVDGLQLGRETPMGEAFIEFQEYCLGLRDRGVLLAVCSKNNDETARAGFMHPSSILKLEHISSFKANWDPKHENIRSIALELNLGLDSFVFIDDNPAEREIVRAQIPEVAVPDVGNDPVRYPAIIEAGRFFESISLSKEDLARATLYAQNSKRSVQAQKFSDYGEYLDSLEMIAEISTFKPVYLERIAQLTNKTNQFNLTTLRLSFSEIEAFSSDPAYIPLYGKLVDRFGDNGLISVVIGRIENTVLYVDLWLMSCRVLKRDMELAMLDALVEKANSHKLESIVGYYIPTSKNTMVENFYQGLGFEPDTGEGMEYPDKRTVWRLNLAGYTKRNTHSKTKEYGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X571</accession>
    <name>E8X571_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1273</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1273"/>
    <dbReference type="EnsemblBacteria" id="ADW68335">
        <property type="protein sequence ID" value="ADW68335"/>
        <property type="gene ID" value="AciX9_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1273"/>
    <dbReference type="HOGENOM" id="CLU_1136791_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="27255" checksum="76D8D96F5FD8FD11" modified="2011-04-05" version="1">MPRISFIRQFCFAAALLLVVGLTGVNARGMGEPQGAGLLTADRVTVERSSQLPGKGSRTVYGLSEGHDHGELIVDRMEDKRLKPELRFNVWAGDVHSFRDDPALPLERRLAFFRPLMKRFLETEKPDPAYGLLFYGYSRLYERLPELAAKDSGWNRTKGQPVSKQPGYGYLESLLTRGGAYRELAETMAGFHYRVGIAGGLEELRVLPVSKLNEGQRAHLPVDVKANDLLPARIAIDFRLTADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X596</accession>
    <name>E8X596_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein LpqB, GerMN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1298</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579683.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1298"/>
    <dbReference type="EnsemblBacteria" id="ADW68360">
        <property type="protein sequence ID" value="ADW68360"/>
        <property type="gene ID" value="AciX9_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1298"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219219_0_0_0"/>
    <dbReference type="OMA" id="THNIGEG"/>
    <dbReference type="OrthoDB" id="1756958at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="24317" checksum="1A2DA5028B1003CF" modified="2011-04-05" version="1">MIPKYQRIVYWTLLGGILLMALLLIHGCIRSRDRVIAQRDASPIAAPVDAPEESAQIATANDSDSTVTLDAITLPLPQEPSVRARILLDRLLADAALPASTHPLPPGPAIAGVFFLRLPINNPADTGQQAHASTSPYGTTHYAGSVLAVVDFTQAFADAHPSSIQSEDLTLRAIMTTLHANFPEVAEVRFLVAGVSRDTLAGHADLTRPYPTTDPATAIHPLAADGNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G4</accession>
    <name>E8X5G4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580827.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2478"/>
    <dbReference type="EnsemblBacteria" id="ADW69511">
        <property type="protein sequence ID" value="ADW69511"/>
        <property type="gene ID" value="AciX9_2478"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2478"/>
    <dbReference type="eggNOG" id="COG4867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055391_0_0_0"/>
    <dbReference type="OMA" id="GPYHTNT"/>
    <dbReference type="OrthoDB" id="171570at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="222"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="46309" checksum="143F3496D38AFF23" modified="2011-04-05" version="1">MKRTRYTKFTGDLSSSFGLEDLMQALSDFLLDSGFNDPMSRFQALDGEQTMDNLREAIRQALESGDLFDDETQEKYEALDEDQVEDLIDNIIQKMQEQNFINAEQPQQGQGEEGGDGESARFEVTDKGMDFLGYKALRELLGPLGKSSIGRHDTRYEAAGVETNGSSKPYEFGDSLNLDITATLSNVFAREGTDFNQHGGKLNLEYSDLQVQQADFQSSCATVVLLDCSHSMILYGEDRFTPAKRVAMALSHLIRTQYPGDTIDLVLFHDSAEHIPIGQLPRVKVGPHYTNTREGLRVAQRVLQRSNKDMKQIVMITDGKPSALTLPDGRIYKNAFGLDPLVIEETLQEVSRCKRSNIMINTFMLASDFQLVQFVQQVSQMCRGKAYFTTPETLGNYLLMDFMSRRMKTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T3</accession>
    <name>E8X5T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572729.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70817">
        <property type="protein sequence ID" value="ADW70817"/>
        <property type="gene ID" value="AciX9_4021"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4021"/>
    <dbReference type="HOGENOM" id="CLU_033323_6_0_0"/>
    <dbReference type="OMA" id="KSFWRID"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="20402" checksum="135ADD6C6FAA652E" modified="2011-04-05" version="1">MTSRVTFISHGATAAVRAASFPLDEGLESGEGSRIAGLGWNGPRAQDVLMGPEVRVRMTAEGLGLTGVVDGGLRDFDYGDWRGLGLGEVEGRDPEGLMGWLTDVEARPHGGESVAGVIERTARWMEGRTAAGHTVAMTCPGVIKSAVVLAMGAPAAAFWRVDVAPLSLTDLRWNGRVWTVRCVSCAINSAAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X600</accession>
    <name>E8X600_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4104</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572796.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70884">
        <property type="protein sequence ID" value="ADW70884"/>
        <property type="gene ID" value="AciX9_4104"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4104"/>
    <dbReference type="HOGENOM" id="CLU_023194_24_0_0"/>
    <dbReference type="OMA" id="WNVNQPG"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="7">
        <location>
            <begin position="46"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="455" mass="50653" checksum="DD6C83168D39A1E5" modified="2011-04-05" version="1">MDLKDTNLNTNRRDFLKTSSLLAAGATVSWNASSYAAIVGANDRVRTAIVGCGDRMKGALVPAFLSHAKELNFQFVAVSDIWNMRRDQGAAMLSEKTGNKVDSVRNNEELYARKDVDAVLIATADFQHAQHGIQAVNAGRDAYVEKPTAHTMPDARNFRAAVHKTGKIVQVGTQRRSTPGYQKAYEYINSGQFGDIVMVEMSWNVNQPGRWRRPDVVPLLKEQDTDWTRYQLDLPKVPFDARKYLEFRLFWPYSSGLPDQWLVHQIDTVHWFTGLPHPRSVVANGGIYAWKDGRVNWDTLTAVFDYGPLDDPTKGFQVVYSTRQTNSAGGVKELYYSTGGMLDMDKRTVTPNGGLTAKYAAEMKMEPKLLKSFSLDDHSEKVSTDANTGSGDPETGANMRNWMECVRSRKMPNASIEAGYSHSIALCMCIAAMQTGTRVTFDDKTQQVVAGGKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X603</accession>
    <name>E8X603_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4107</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572799.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70887">
        <property type="protein sequence ID" value="ADW70887"/>
        <property type="gene ID" value="AciX9_4107"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4107"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_0"/>
    <dbReference type="OMA" id="TSWQALK"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="34451" checksum="2CE550CFB8C85252" modified="2011-04-05" version="1">MKAARLADPSRSSELDLEDVDLPLVGRGEILVRVAAAGVTPSELLWYPTTHTKEGERRIGVVPGHEFSGIVEAIGAGVHGFFPGDKVFGMNDWFSQGASAEYCIASPLTLAPKPRTLSYAEAAAVPIGALTAWQALFDRADLQAGERVLVHGGAGAVGTFVIQLAKLHGAEVIATASAANMDFLTSLKADEVINYRATRFEDQIEPVDVLFDAIGGETLQRSWPLLRAGGRAITVAAQSEGVEDARIKAAFFIVDASREQLLDIGLLIDGGSLRPFVGAAVPLSAAADAYGGRIARKDGRGKVVLLMPDFEEKDVGTRNSSSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X633</accession>
    <name>E8X633_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4137</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572829.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70917">
        <property type="protein sequence ID" value="ADW70917"/>
        <property type="gene ID" value="AciX9_4137"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4137"/>
    <dbReference type="HOGENOM" id="CLU_2058056_0_0_0"/>
    <dbReference type="OrthoDB" id="2200907at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="12868" checksum="D404869192A93181" modified="2011-04-05" version="1">MSAWQAVARTEDNTSLLDSVDGTSALHGVRSPLGQPITALRPLIAQLTSAWKWLEQKRTQQIATRRLKVAETVSLGEKRFVSILQVDGAQFLIGGAAGNVTLLAILDKQQDAVSMEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X659</accession>
    <name>E8X659_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4163</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572855.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70943">
        <property type="protein sequence ID" value="ADW70943"/>
        <property type="gene ID" value="AciX9_4163"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4163"/>
    <dbReference type="HOGENOM" id="CLU_1287320_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="22990" checksum="B17CB19B72044BF2" modified="2011-04-05" version="1">MALKSTNSMTARVEGSFKQLSSAAQTLHSATDDLSKVIRQLDVSLKKLGLGFPAWVQVSGEADEVQYLSHDLGYAKVDGKWGLALREVTGNHLDTDDDAEEIWGFNDAPRALRVDAVGKIPDLLEKLLAQTEETTKKLQAKIAQAAELASVFSDLTGGVPALPQWNRHGIASESAREIEGNGGEKPAAASFREGVSFPGERALPVEKPLPAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X667</accession>
    <name>E8X667_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70951">
        <property type="protein sequence ID" value="ADW70951"/>
        <property type="gene ID" value="AciX9_4171"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4171"/>
    <dbReference type="HOGENOM" id="CLU_859869_0_0_0"/>
    <dbReference type="OMA" id="GWLRTTL"/>
    <dbReference type="OrthoDB" id="1630136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="34293" checksum="798F86291C67ED85" modified="2011-04-05" version="1">MAYLEGVDSVSLQDAVVLEPEESRGVMGVASEAVLDELWRGAEAESVGLSRAEFVGALVRVGEKCGYGLGAGVVAGTAEKERFWRGLQGADLALAQACALGREVAWERFVARFKGPLRRAAVAMTRSSGLGEDLADSLYSELYGLKERDGVRASPLASYSGRGSLMGWLRTTLAQRHVDRHRKTGREEPLEDHEPTSESPDVGHPVYEAALEMAVKLVLGGLGAEERFLLSAYFLDGRTLLEIGGLLRVHEATISRRVKRLTGDVTKRLLKELQARGLSKRAAEEALGTDPRDISVNLRNVLQSSGSGTFSEKTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B1</accession>
    <name>E8X6B1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70995">
        <property type="protein sequence ID" value="ADW70995"/>
        <property type="gene ID" value="AciX9_4217"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4217"/>
    <dbReference type="HOGENOM" id="CLU_139747_1_0_0"/>
    <dbReference type="OMA" id="HHEYVEE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230274" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="10835" checksum="26965485018E1C20" modified="2011-04-05" version="1">MLKKLAVATLFASLLPLASQAQIAIRIGPPAPVVEHYGPPPHPGYVWQGGYHRWDGNRYAWTPGHWGRPPRPGAVWVPDAYDHRGDGYHYHAGYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C8</accession>
    <name>E8X6C8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4236</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71012">
        <property type="protein sequence ID" value="ADW71012"/>
        <property type="gene ID" value="AciX9_4236"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4236"/>
    <dbReference type="HOGENOM" id="CLU_3118378_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="50" mass="5797" checksum="BEAD2FF0F86402AC" modified="2011-04-05" version="1">MQCTYQILATPQPRVLARVLQLFDQQLMLMQSLVFTQSEVESQIRISAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D1</accession>
    <name>E8X6D1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4239</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572927.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71015">
        <property type="protein sequence ID" value="ADW71015"/>
        <property type="gene ID" value="AciX9_4239"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4239"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233737" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1240" mass="131947" checksum="E4C72BB8BB0E6591" modified="2011-04-05" version="1">MLRKLTLTLLAFATMFLAATPPAGAQATTTGNLAGTVTDPSGAAIPNAKLIISDPATGSRNTQTTNSVGAYTFSDLQVGTYILSTTYPGFATTVTKDIGIETGRSINLNVALVLGAANTEVEVISGSEVLETTTNTLAATIKPDAVQDLPLNGRDASSLTQLAPGSQSAGDARYATFNALPAAAINITVDGMNSNFQKFRTSTSGNYSPSPVRLGAVEEISVSTSSLTADAGAEGSVALRYQIKRGTNKYHGSAFWQYSSSLLNANSYGNDAAGIAKTKTHTNDEGGNIGGPIWKNKVFFFSNYEQNFANGKTQVTAYALTTAAQAGNITYTDSANVVHPVNVLNAAATAGFNSTINPRIASELSQINTYNQGAVAKATPLPYQNLENWSFNTITKNVYPTERIDYQITPTLDAHIAYDLWWRSLPGSQVYAGDPTHTEFRSSYSTLTFGTDWTITPHIVNQVNLGLLNDQERYNVTASFTPYAAINNILYASPTFTNGGSVAAPTLYTAALPEPRNNPVRDVFDNVTWNKGKHTFTFGGDLRNSTAHDLSISNPPVSTLGISTTDPANTGLFNQANFPGLITSGSSTPDLNNLKSLYATLTGRVSSIAGSNAYDTASGNYKVLGDLVIKEAQTVGGFYFQDSWRPTSHLAFNYGMRYQFSGTTHNTNNIYTSPTIADLYGPSTGEFAPGSLGGIANPQIYLRPSTYSADLNQPAPNAGFAWNPGFDGGKMVVRGGFSISHYDEGWGDWEAASSTNPGIRQSASILPGTGTGQYTPGSITLGTIPTLNTSPATFAFPLPESNFTFTNTLSAMDPKIRSPYVESWYFGVQHKLGYNTAFEANYVGNHVIHAWQTFNINEVNIYENGFLAEFQKAQADLAKSTGGNSSFYGADLPILNQAFGGAAGAGFKNSTFINYVQSGQAGALANAIATNSTYFCNLVGGGTFAPCTKLGYVGATAYPINFFQANPYSSGTARLTSDPGSSQYNGLQTQIKHPPGHGLTLQVNYTYSHAFSTRYTTTSDSGTVDFITLRNLRLNRNPAPSDIRNALKAYAVYTLPFSGHSYFMKQVLNNWTVSPILTWQSGRNFKLTGGTATVNTSDSGLVLTGINAKQLQKSVGYYPGPSVSTPLLLLNPAVLTKTNGVAQVASESTPGVIGQQVFLTAPQFVNTDFSVSKILPVTEWVKLNFQAEMLNVFNHPSFTYGPGSPGNSAAINTSPAVIASTSPGTSPASRAFQFRLGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V5</accession>
    <name>E8X6V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter, major facilitator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3981</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71255">
        <property type="protein sequence ID" value="ADW71255"/>
        <property type="gene ID" value="AciX9_3981"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3981"/>
    <dbReference type="HOGENOM" id="CLU_059352_0_0_0"/>
    <dbReference type="OMA" id="FWFTISF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="40442" checksum="A5253B9ACCF39B6C" modified="2011-04-05" version="1">MQGVAKSKTFPWGALPLYLGFFGTGIGVALPGALLPALQMRWHLQDEQSGRLFLMAWIGSSLGALLVRRSLRTTLVFGSLGVAVGAAGLALSGGHGVNALMALYGMGLGATMTSVSLIRQQQTVGSGTEMVRLNLVWAIGACACPSLTVHALGAGDFGPVLLGLAGCFLALAGAALAQRELMVLTAGAEVGDAWAIFRRMPLGLIAMIFLVTGIEASAGGWLTTYTRRGGHELAEAVAAPTCLWAGLLLSRLFWSVRDKWLSEAVVVRGSLVLMTAAAVLLVATTHGVAILAAAFLLGFGIGPTYPLLLGWALRYQRGGAIFFVAGVGSACLPWMTGLVSAERGSLRMGLVVPMVGTAVMLLVAMVSPVRSWGGAVPVKTRFGTPLGDNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X712</accession>
    <name>E8X712_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71121">
        <property type="protein sequence ID" value="ADW71121"/>
        <property type="gene ID" value="AciX9_3835"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3835"/>
    <dbReference type="HOGENOM" id="CLU_285085_0_0_0"/>
    <dbReference type="OMA" id="WPIEQDY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028028">
        <property type="entry name" value="DUF4450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14614">
        <property type="entry name" value="DUF4450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234473" evidence="1">
        <location>
            <begin position="30"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1129" mass="123438" checksum="AFC963E9484BC8E3" modified="2011-04-05" version="1">MPSLWTRRRFLSHSSASALLAAHHPSLLAGQAARPQSAATSPEEIAGSVRGLMHGKTERPLRYRPEQGGFTIRNSSEFFNRPLYGQNIAFRVDAGDLPEFSLYMPGHGGNLRLGFTARGTAKWLSQADEIVATYHAGRMSYTINDAALGSNQLRLDVVTAAQGPGLHIRVQSTLAKDEVQMLYAFAGASGRKGKRGGDIGCESEPVSQFFQVRPMECAGNNYTIEGHTARLTSKAVNLSFDFPPGTTALIGDASRWNDGWQALADSAASGPALPALLASVKLSATPLHLRINGDVTIDAEEAYVRRCAQLDAVASRVSLQTPDPFINAIGPAVGIAGDALWDEAQHCVMHGAVAWRNPLAGWRGPYVLDALGWHDRFIQHARHWIAKQNIAPVTTAVPAIGQPDPGSHLSRTENLLHSNGDLSHNHYDMNLVFFDALLRHLQWTADLAFAAEIWPALERHLAWEQRLFRRLYDGLPLYEAYACIWASDNLQYNGGGATHSTAYNLFANRMAAQIAAMIQKDPAPYEREATLIQKAMQTHLWIGSQGTYAESKDLLGPQAVYTSPALWSVYHAIDSRAATPRQSWQMAVERLSAIRSVPVSGLSVPPGGTMLSCSDWLPYEWSLNLLLLAENMHMALALWQTGMVDEAYSLFKGNLLDSMFQGLCPGNFHMTSQLDAHRQEAQRDFGDPIGITARALIEGLFGVQPDLLHNTLHITPGFPSDWNNASLHHPDLDLAWTRTGNRESCEITSRLGRPVALSLKLRAPSTGQPRVSINGTPATGAFIAEAVGAPSLHIQAQAQTHWTVAIEWKGPAAAPRPAHRIVHRDDIVFPPSQIIDDPQRALNQGRATRPGTHTVFTQAGTPDCQWWMPHTFLVLDPSPAPATQPLGTSRPIDLTAHLNSSITEIFERDYASPRSPYCSLSIPQQGIGAWAAFDRRPSIDDTGLRSLNGELRIPYGPTFRTPGGAAPNCLYLSHWQQDKPTIRIPLKGSAKMLSLLLAGSTFPQCSRTDHAHVHVSYTDGTRSSLTLRNPENWWPIEQDYLIDDYLFVDETLPPTRVDLKTGKVRSLTQAQIQTQIQTQAKGNGGHIPGGAATVLHIPLDPSKTLSSLEITVHLYGIIVALLAATLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X762</accession>
    <name>E8X762_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4344</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71296">
        <property type="protein sequence ID" value="ADW71296"/>
        <property type="gene ID" value="AciX9_4344"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4344"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="AGDACRW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="18549" checksum="F552AA2E95A434AA" modified="2011-04-05" version="1">MTIPHSLTHTKVTHSLRNARATVTILLVDDNHLVRELTKTLLRQVGYAVAEASNGQSAIQQAQTRRYDMLITDLEMPEMDGFELARHLTKDRAALPVLVLSGALPNVVPLQELQKRRWAFLPKPVDRKELIRTIDNNCLGWALHTQPGSSPQRSKLPIETMTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X785</accession>
    <name>E8X785_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4367</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573038.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71319">
        <property type="protein sequence ID" value="ADW71319"/>
        <property type="gene ID" value="AciX9_4367"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4367"/>
    <dbReference type="HOGENOM" id="CLU_2232751_0_0_0"/>
    <dbReference type="OrthoDB" id="1723076at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="105" mass="12074" checksum="69BD6D56062FE84D" modified="2011-04-05" version="1">MPIIGPTTDHSEIRRWAETHNAIPTEVLPHDVDSEPALIRFMLAEQAKDHSDMRLIPWEEFFLKFDSLGLSFVYDDGSTGYNEILQIEELSPYSKAERNAASFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A5</accession>
    <name>E8X7A5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573058.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71339">
        <property type="protein sequence ID" value="ADW71339"/>
        <property type="gene ID" value="AciX9_4388"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4388"/>
    <dbReference type="HOGENOM" id="CLU_698041_0_0_0"/>
    <dbReference type="OMA" id="RQFRNRK"/>
    <dbReference type="OrthoDB" id="571864at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="44361" checksum="601204A0F2F32091" modified="2011-04-05" version="1">MFSNVRPDKRKPTLAQRQHQKMAESAHAYVRGNTARFYDWLASKSVQAALPQGPSVWICGDCHTGNLGPVSDLEGNIDIQIRDLDQTVIGNPAHDLLRLGLSLAMAARSSDLPGVTTALMLEEMIGGYLIGLAGRTERVDLKEVQPIRSVLVAAKNRQWRHLAQERIEDVKPNIPLGKKFWTVTEEERSELNSLVEGDGFRQLLQTIGGKEPKRVELLDAAYWMKGCSSLGNLRFAVLMGVGSKKHPEYRLLDIKEATLTAAPSAKGAKMPKGYADRVVAGACALSPFLGERMLAATICRRPVVVRELRPQDLKFELVGLEQSEAIAIARLMAGVVGRAHGRQLSREERYAWSHELKSRHGKGLEAPRWLWSGVLDLAALHEAAYLDHCRRFAMRQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B6</accession>
    <name>E8X7B6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4399</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71350">
        <property type="protein sequence ID" value="ADW71350"/>
        <property type="gene ID" value="AciX9_4399"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4399"/>
    <dbReference type="HOGENOM" id="CLU_2537837_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="9620" checksum="BAF69E6B76B6F904" modified="2011-04-05" version="1">MRAELTQEDFEAQWRPIPLDHFPLPACSQGMILLKAFADAHPGPFEFIRPEDFVHYENEAFAGIEEWDAFARHCLSCHDCNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L0</accession>
    <name>E8X7L0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573163.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4500"/>
    <dbReference type="EnsemblBacteria" id="ADW71444">
        <property type="protein sequence ID" value="ADW71444"/>
        <property type="gene ID" value="AciX9_4500"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4500"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051474_4_1_0"/>
    <dbReference type="OMA" id="WHTTEVI"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="36"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="199" mass="21879" checksum="EB2B0E2D4E6C5B6D" modified="2011-04-05" version="1">MRKFWLVFAVVVCIMTGMAISYLTVPKENGQLESFDAIIVIGCPTADDGTLSPMQKARVLEGVKEFSAGKAKHLIFSGGASNNHSIESQVMAQAAAEMGVPNEAVFLDQEANNTLGNIFFSHLIMTGKGWNSAEVISSQNHLPRLGVILALYNFSWQTHAAPWPPNINPLIKFLYYGREVAATTVVRWFGFRSNDLVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R9</accession>
    <name>E8X7R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4573</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573222.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4573"/>
    <dbReference type="EnsemblBacteria" id="ADW71503">
        <property type="protein sequence ID" value="ADW71503"/>
        <property type="gene ID" value="AciX9_4573"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4573"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_4_0"/>
    <dbReference type="OMA" id="PWKGQHI"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="44661" checksum="2E3B198C723E52D3" modified="2011-04-05" version="1">MQRKIRVLFVNHTAKLGGGELALCALIRHLDPALIDHRVLLCEEGPLVERLRMFTEVHVEPLSGELREARKDGLSSGKIDFFKKGMELVGYVWRLSRTIKRLRVDLVHTNSLKADILGGLAARLAGTKVIWHIRDRIEVDYLPARVVSFFRQLTRWIPHAVITNSHATMETLHLIPHGDLRKERLAWKGLSRVIHDGFDFSTSSKKQAITAGAVTIGLIGRISPWKGQDVFLRAAAIVHQSFPEVRFQIIGSALFGEEEYERHIHKLCMDLQLDCCVDFLGFISNIQMEIERLDLVVHASTIGEPFGQVVIEGMAAGKAIIATRGGGIPEIVLNGETGILVAMKDSQSMANAMLTLLSHPEQRAEMGNKGFQRVVDYFRIEKTADGVSRFYQELSQSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T8</accession>
    <name>E8X7T8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4592</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71522">
        <property type="protein sequence ID" value="ADW71522"/>
        <property type="gene ID" value="AciX9_4592"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4592"/>
    <dbReference type="eggNOG" id="ENOG5033FFN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015388_0_0_0"/>
    <dbReference type="OMA" id="IANIPMQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="28320" checksum="56AAA370F46F1D8D" modified="2011-04-05" version="1">MKNGLEVGGRFVGNVCLGIALAAAGLGLGGCKVGSSGGSGGTGGGGGTSDPNHVYATGNWQIQATPTKGVAPFTSLGGFINEQGTDPGINDLTTGAFQAQSTSCYVNTPTVPLQGAVLAYQLGLRSFAVDGQFLTISAAEDATVTHMTGTYSITGGCADGATGNLAGTKYAALSGTYKGSVTAGTTPETMQLVLSQFQQGTGDGVFLVSGNASFTGFSCFNQASLASADGGIAGSAVNLSFVTNDPTSARLLLTGTITSDAKTFNVSSAMVTGGNCAGSIGTAVLTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X841</accession>
    <name>E8X841_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4698</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573343.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71625">
        <property type="protein sequence ID" value="ADW71625"/>
        <property type="gene ID" value="AciX9_4698"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4698"/>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_0"/>
    <dbReference type="OMA" id="CINKITT"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="27285" checksum="307F86AB86AB74EE" modified="2011-04-05" version="1">MTIRALIVEDEPLAIDRLRSCLAYASELDLVGEARNGAAAVEMIDRFKPDLVFLDIQLPILSGFEVLRSVEYRPAVIFTTAHDEYAVPAFEWGAFDYLLKPFDKERVALALSRFQERSGLSDGGVALVERLDTMESKGALQRFFVKQRGVTIPVDSEHIVAILAEGDYCRVHLENENHLVHLPLREFENRLSSVLFRRVHRSALINIAKVVRIEASGRGANVSMQGGVTAPASRSGLAQLKSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ2</accession>
    <name>E8WVJ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1381</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579762.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68440">
        <property type="protein sequence ID" value="ADW68440"/>
        <property type="gene ID" value="AciX9_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1381"/>
    <dbReference type="eggNOG" id="ENOG5030MN3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2806433_0_0_0"/>
    <dbReference type="OMA" id="SDEQEIP"/>
    <dbReference type="OrthoDB" id="2066416at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7484" checksum="F81E7B1C1F153B8F" modified="2011-04-05" version="1">MNFNDGTTNRDLNSSKTAVDASHESGDSKDVATTKQEQLDGVAMESAKRANNRIHSDEQEIPGSTIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW3</accession>
    <name>E8WVW3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="10" type="ordered locus">AciX9_3721</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582031.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3721"/>
    <dbReference type="EnsemblBacteria" id="ADW70722">
        <property type="protein sequence ID" value="ADW70722"/>
        <property type="gene ID" value="AciX9_3721"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3721"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_0_0"/>
    <dbReference type="OMA" id="NSEYHSA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="8">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="18894" checksum="831ACEE19AE304F5" modified="2011-04-05" version="1">MPEHIKAKLAEEIKALEYELTTELPAEIKKAVALGDLSENAEYHMAKQRQVFVNARLGQLKKRMGELAMVNLANIPHDKTGFGSRITVFDSTKDEEIVYQLVTSEESDVSKGLISTTSPIGRALLNKEVGDTVTVVTPNGKRELEVLKLATIHDIALELAAVHETAAAGTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ8</accession>
    <name>E8WVZ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage shock protein A, PspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3757</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582065.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3757"/>
    <dbReference type="EnsemblBacteria" id="ADW70757">
        <property type="protein sequence ID" value="ADW70757"/>
        <property type="gene ID" value="AciX9_3757"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3757"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056466_3_0_0"/>
    <dbReference type="OMA" id="KDMYIAR"/>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="25407" checksum="20931C9B41F10AD6" modified="2011-04-05" version="1">MALLERVSTLLRANLNDLLDKAEDPEKLSKQIVLDMENQLLQVKTQVAVAIADQHRLGKQQQEHEAQAAEWRRKAELAVGKQQDDLARAALERSLSHQKLGEGFAQQHTDQTAEADTLRSAYSKLQGKLTETKARIELLLAQHRRNKALAKSDPGQALLSAGERAARLERLNATVAAGELTASTNRTVRAIAGSDTLEDRFQSLEQEDQIEALLLELKENHPRLSNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW13</accession>
    <name>E8WW13_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0245</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578647.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0245"/>
    <dbReference type="EnsemblBacteria" id="ADW67319">
        <property type="protein sequence ID" value="ADW67319"/>
        <property type="gene ID" value="AciX9_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0245"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153182_0_0_0"/>
    <dbReference type="OMA" id="LIRMFGP"/>
    <dbReference type="OrthoDB" id="2002329at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="12094" checksum="A49CE58EAA027C55" modified="2011-04-05" version="1">MALTRDFRETIRERAQSEPAFRQALLREGLQLIYDGDLATGRSILRNYINATVGFTELSKMTQISSPSLQRMFGPNGNPTVENLFGVIGHLQRHERVSVELQMHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD4</accession>
    <name>E8WWD4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1464</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579837.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1464"/>
    <dbReference type="EnsemblBacteria" id="ADW68517">
        <property type="protein sequence ID" value="ADW68517"/>
        <property type="gene ID" value="AciX9_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1464"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011139_2_0_0"/>
    <dbReference type="OMA" id="FFKGSEM"/>
    <dbReference type="OrthoDB" id="271104at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233921" evidence="2">
        <location>
            <begin position="22"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="4">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="303"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="794" mass="87577" checksum="ECC27B67E8C172B0" modified="2011-04-05" version="1">MSARIQLLLALLLVAFIPARSQSGVLVPKDKDQPDPAVLSLEEMNVEIVIDNGDARIFVTQIFANHTNQVEEGNYTFALPTGSTVSDFAVWDGPVRIPAVILERKRAEEIYSEARAQAIDPGLLEAGERDGSDPKADSTFTAHITPIPAYGTKRLELEYHQKLKVDRLGQSFVLPLKPADAAQQTAAHLRIHIELHSSIAISNFHLTNQAFPLQFSKQDAHTVVGVWQSNNVTFTDDLAATWTLDPKAADTLIVSTFRNPHPPLPSATERSPKPPQPEPGFFLAQTLIAPEPPATTHASEPRNVILLLDTSLSMQWDKLERSYAALETVLRSLQPTDRFSLMLFNQDLSWFRPDPTQATPESVQEALQFIRASRLRGGTDLGKALAAALTQAKSPNQSLYLFTDGNSDRGVTILDNKIAAAYTQQWNHSTHPRTNVFAIGDDANLPLLRLLARNDGLFENVLTTEPLQPKLDVFLAHSVSHPTPGLHLEAAPSASVQNVYPLDEAVYPGSLAAWVGRYLTPTKHVTFTAQADREGKPLIASATLDLPAESLEHPQLPRLWAQARVNILLDQITREGESRAAIDEIIELSRRYKFVTPYTSFLAAPRSLLRPRVIRPGDPVLRIHTDPTITSVIALFPFGLTKPLRHLPSEDTTKGPDSDRLWETRFLAPTDMSDGTYQVRLILRDVRGNTYSEQKSFVINSTPPTIRIKLERIRFHRGEIMLVKAGAPASTQTLTAHLEGAAPVDLRWNNAAAANTGQLRIPDTMAPGTYTLSVTGEDLAHNVGSQEVRIEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE4</accession>
    <name>E8WWE4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2583</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2583"/>
    <dbReference type="EnsemblBacteria" id="ADW69608">
        <property type="protein sequence ID" value="ADW69608"/>
        <property type="gene ID" value="AciX9_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2583"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952375_0_0_0"/>
    <dbReference type="OMA" id="ETYRAEA"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="32523" checksum="0C5203254EFB8A7D" modified="2011-04-05" version="1">MPGSDLPIRPVVRTAAGSEGRQASREHLADEPEEAEELSDDLGPEADEDGESKSAESDDFAQPAGEDGVTEDMSTLALNPTNLEGLADAEARQAGLHTNGNFGELDDAAIMLELKAGNMAAFDFLMVKYRKPIIHFMFRMTHNQAVAEELAQEVFLRVYRSRETYRAEARFSTWLYRIATNLGVNHARDTRHERSAATVYLDEPDSETGTSPDVADSTPGAEAGILRRERMEAIRAHVISLPERQQMAVLMHKYEGMDYKQIGEVLKLSESATKSLLFRAYQTLRDKLKDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ5</accession>
    <name>E8WWJ5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2634</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580974.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2634"/>
    <dbReference type="EnsemblBacteria" id="ADW69659">
        <property type="protein sequence ID" value="ADW69659"/>
        <property type="gene ID" value="AciX9_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2634"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_4_3_0"/>
    <dbReference type="OMA" id="EYAGMET"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="PTHR33359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="11592" checksum="D87E2DB16FF53851" modified="2011-04-05" version="1">MSQKRDMGHPIVSVHNAVGYAELVIVRVLYFGVLKDFVGVAEESMHLDVGSRVGGLVRDLAGRSSKSGEGLGGMMGSIAVAVNREYAGMETVLNDGDEVALLPPVSGGCCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ9</accession>
    <name>E8WWJ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2638</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2638"/>
    <dbReference type="EnsemblBacteria" id="ADW69663">
        <property type="protein sequence ID" value="ADW69663"/>
        <property type="gene ID" value="AciX9_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2638"/>
    <dbReference type="eggNOG" id="ENOG50339RM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199613_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043727">
        <property type="entry name" value="DUF5670"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18919">
        <property type="entry name" value="DUF5670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="5506" checksum="2ADD25020FB0D334" modified="2011-04-05" version="1">MLWTITIILVVLWLLGMVSGYTLGSWIHILLVLAVIVLIFNLLSGRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN3</accession>
    <name>E8WWN3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FolC bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3778</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3778"/>
    <dbReference type="EnsemblBacteria" id="ADW70778">
        <property type="protein sequence ID" value="ADW70778"/>
        <property type="gene ID" value="AciX9_3778"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3778"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_0"/>
    <dbReference type="OMA" id="HTPSFFE"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="571" mass="60401" checksum="3C5ABF8631CC136B" modified="2011-04-05" version="1">MGSMTYAEALEHLYGLGPELAPIKPSSDSEPSSTPPRHKFDLIHMRRLCAALGDPQNKVPAVLIAGTNGKGSTSATLASILVAAGYRTGLYTSPHLTRVNERIQLAHPILPTEYGAPGANGPLALSPIPDDLFADLYTQVDTAGTTLVAAGDLPYPPSFFERLTAVAFAYFAHQQAEIMILEVGLGGRLDATNIVEPLISVITDIALDHQDYLGDTIALITAEKCGILREGGTLITLPQLPEANQAIGIAATALNVQAINAAQYIPPPQRASDPPHSAVPHATGVPSNEVVILSEAQNLRISLGSAQAPPEAPPDFTPHYHPHQGTPQITDEPGAPQPALSLPKGLGSETWVPASTLPRNHYTLSLDDQTLLQVDSPLPGTHQQRNIALAIATARAISDSCSLIPVPFRIPPEAIEQGIRTTVWPGRLELLPPNLLLDVAHNPAGAWTLRSALASLPEQQPRTLIFSCLKDKSLEEMSRILFPLFDSSPDADPLRRHDHIILAPIANPRAAAVEDLLAAAHALQIPAHAAPHLAAALAQAKQITPPGGLIIATGSVYLVGEIRDLALGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR2</accession>
    <name>E8WWR2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="2">CMK</shortName>
            <ecNumber evidence="2">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ispE</name>
        <name evidence="5" type="ordered locus">AciX9_0318</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578718.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0318"/>
    <dbReference type="EnsemblBacteria" id="ADW67390">
        <property type="protein sequence ID" value="ADW67390"/>
        <property type="gene ID" value="AciX9_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0318"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_0"/>
    <dbReference type="OMA" id="PQAFRDW"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="1 2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="4">
        <location>
            <begin position="284"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="40417" checksum="BDCF5F11C7BA8AE4" modified="2011-04-05" version="1">MPTHVRSYSKINLGLAIGPPRSDGFHSLVTLYQTLALYDQIALVARPAAVTRITLRSNDPRVPLDARNTVWKMVAKALSVLNRTAEVTVHIQKNLPIQGGMGAGSANAAAALIGLEKALCLSIPPETRLEIAAQVGSDVPLFLVGGASFGSNRGEAVTPAPVITFEGQSEIPCVIALPNVGVSTPQAFRDWDARFKSAPDLHNPPIRDTMNELSRTYASVFGYQGEMESNQSGASGIFPEPSLSVASGSPEKLQGTPDEQLHRSPETTDRSGIKIDLAENSLLALVRTGIENDFETVVFPQYPSLREIKRHLMGPSEQENSAIIAALSGSGSALFGLYRSKSHAEAAQQRLQQHGVKALVTTTLPRPLYWSDMFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ5</accession>
    <name>E8WWZ5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_1503</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579876.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1503"/>
    <dbReference type="EnsemblBacteria" id="ADW68556">
        <property type="protein sequence ID" value="ADW68556"/>
        <property type="gene ID" value="AciX9_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1503"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036876_4_0_0"/>
    <dbReference type="OMA" id="TYFWFTP"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="13">
        <location>
            <begin position="91"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW68556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26297" checksum="119B0678D0767E29" modified="2011-04-05" version="1">MSPGWYLPPNASTQGAPLDSHLSLNLWIAVALLTLAHLILFVGLLLRRRAEARSSNLIEYIPLTALAILFAFLTLRAERLWAATRYVGAAPSALQVEATGMQFAWYFRYPGKDYAFGRTRPELAEPGNGNPLGLDPTDPTAKDDLVTSELVLPAGREVDLHLHAQDVIHGFSVPAMRVKQNAVPGQSIHIHFTPSVPGTYAILCTQLCGLGHYRMTANLRVLPPEEFAAWLRAKEAAVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX11</accession>
    <name>E8WX11_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S10 serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579891.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1519"/>
    <dbReference type="EnsemblBacteria" id="ADW68572">
        <property type="protein sequence ID" value="ADW68572"/>
        <property type="gene ID" value="AciX9_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1519"/>
    <dbReference type="eggNOG" id="COG2939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032786_0_0_0"/>
    <dbReference type="OMA" id="TATAWYH"/>
    <dbReference type="OrthoDB" id="835305at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="526" mass="57127" checksum="02CE0D457DE69C68" modified="2011-04-05" version="1">MRSGLGFGIVAAAAMLCGVVEPMSAQSAAASRRGTQGEAATAPEEQSVPIPPETTSVTKHDWTGGGQTIHYTATAGNILIRDEKDKVNGSIFYTAYTQDGVESKNRPVTFFYNGGPGAATIWLHMGSFGPVRVITQSPEATSPAPFETVANQYSLIDRSDLVFIDAPLCGFSRAVGKGTAKDFAGTDQDIHAFEQFISRYITVNQRWNSPKFLFGESYGTTRSAGLVSALQNDGIEFNGVTLLSTILNYGVRSAGYDTEVIGYVPSYAAIAWQHNKVKHTGSIADWVEQARKFAGGPYLAALREGDALPPAEFDAIATKLAGFTGLSVGYIKEARLRIAPTRFRKELLRDDDKILGRYDARFEAYDVDAAGENPGFDPSDTGISGAYVAAFHDYIQRELKYMSTEPYYLSGPGVSAAWDFKHRPSGAQGGGGGRGEQPVPDVAMDLADAMRKNPKLRVFSANGYFDLATPFFNTEYDLHHMLLPPAIASNIQFGYYPAGHMVYLNVDALKTMKGDMERFYGEATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX36</accession>
    <name>E8WX36_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2653</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580993.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2653"/>
    <dbReference type="EnsemblBacteria" id="ADW69678">
        <property type="protein sequence ID" value="ADW69678"/>
        <property type="gene ID" value="AciX9_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2653"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263224_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230018" evidence="1">
        <location>
            <begin position="19"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="835"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1279" mass="133256" checksum="9FC84AA706960EBB" modified="2011-04-05" version="1">MKLRLFLFLIFSLSIAHAQTITPNESSIVLQSPKKIGINLNGPTYYQGGEIYKNLLWRNPGFEPDLYRDKFVAFKAGTTTTFPSPNTYDPVIANFWMGATFRIYRGTARTVACSGTVASNTTAKNNAGPVYTFSQPCSSAVQEGDVIILRQAIACTTEAVWEGQGGGWWGNVSNGGKLLSECSAPYDGTQSLRLDATVSGSTAGVKGYVDTNPSDVGILLNGTYTISGFYKTIGSATLSVDARRLVTSAAGSPFLCAGKTFAASSAWTSFTVTCPATETNQVAAGPVDVDFEAQSGAVLLDNVSFQKTSGVDPTNTTVFRDELLNTLKAHCAGASLSGVPCELRDWAGENAEEIDNSIKPMFERSPSLPGASYDYPPNGGTGSLSVGLEEFLQLCKAINAEPYYTLPETTGPEDGGKWIEYLNGAVSTPYGAKRAANGQTASWLSVFPTIHLPMGNENWNEGATGQGLGYRVDAPDYYYDYSVDAAGVWATMRGSASWPAGGTGIDLVLGFQDGNANYGVTEAMARANPNSAELAPYTQAYIGDVTPVTSLWNPLFYEVVANTTNPDTTFYQQGTAIKSHGKLNVYEFDNGTSQGSSALTQSVLDSFTDAAGYGTATALQALQHLTFGIVDQNFFSLDQYAFYIPAVGWVHNWGAVIDMGGATNAVRPQELGMRMANAAIIGPMYSCPVANPTTYNLLANHNGADSSGEPATNNVPQQFSYCFKSGTQRSMIVINTDVAGSHAIGFAGPQMPSGQVILTRYAPSSISATNEATANNPTNTAAQNVSINAPFTVANPSGDTLPPYSITRYDWTASTNTVSPTASNATLTVSDTAPLTGVPVVLTSTVAPSAATGTVTFQDFGAAFATAPLIGGSAIYTVASLTAGSHTITAVYAGNSTYAASTSAPLAMMVGDLPALPTNRKPTSTTLSFPSSNPAGNSSFTIVASTDSTSVTGTIKFFDGPTSLGTAKLSRGNAVYTVNSIAPGTHLYSAAYLGTSLYSASTSPVSVVTAATIPTTLQLTSSSTAPAVGSSILLKASVVSSAASGTVSFLDGSAIIGTANLVSGTANFTLPAIASGTHSFTASYAGNSTYSPSQSTAILVMPHAAIPYLHTNFDEHPAGTALNKTLPATNIVSGVWSDPNGDWTYIAGGGIVSDTSDLSNPVFIDAAHSDYTATYVLPANGVHLLFRYTDLKHMLFVVTYAGEVDLYSTIGNSTKTLATIYPSSTVGTVTVSLLGQTAILSCGGQTATATIPANLPVSTKMGFFPTSSKYVITSLDVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA0</accession>
    <name>E8WXA0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ordered locus">AciX9_2718</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581057.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2718"/>
    <dbReference type="EnsemblBacteria" id="ADW69742">
        <property type="protein sequence ID" value="ADW69742"/>
        <property type="gene ID" value="AciX9_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2718"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_0"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="331"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="407"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="407"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="51976" checksum="AD7888CF67474F63" modified="2011-04-05" version="1">MLIDEALAGIDVLERGSGSADVTGVQYDSRRVVAGDVFVAMKGESSDGNRFIETAIAHGARAIVTDSREAWAAGGAVPFYLVGNGRRALAGVAANVFGHPEHVLKISAVTGTNGKTTTAFLLEQMLKSVNRKCLLIGTIETHIGDEVRVSEHTTPESRDLLALFADGVKAGCTEAVMEMSSHALAQERVWGVPVDVAMFTNLTQDHLDYHGTMERYFQAKARLFEGVGAEAPRVAVVNEDSPAGVWLLTRDLGPEVMSYGINAGEFRASKVALSAGRTQFLWETPYGAVQIDSPLTGKVNVYNLLAASCAAMGRGLTLEEIAKAAQGLHQVPGRFQTVPNDLGITVVVDYAHTDDALRNLIGLARELVGKGRVITLFGCGGDRDKTKRPKMGRAAGEGSDLVVLTNDNPRTEEPGAILDEALAGVRETSVECVVEPDRATAIALAIKAVKGGDIVLLAGKGHEKVQILKTGTVPFDDAEVAARVLREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB0</accession>
    <name>E8WXB0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0371</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0371"/>
    <dbReference type="EnsemblBacteria" id="ADW67443">
        <property type="protein sequence ID" value="ADW67443"/>
        <property type="gene ID" value="AciX9_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0371"/>
    <dbReference type="eggNOG" id="ENOG502ZZ7J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155940_0_0_0"/>
    <dbReference type="OMA" id="FFYDDPH"/>
    <dbReference type="OrthoDB" id="1121506at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26723" checksum="12916C32E9BD4C18" modified="2011-04-05" version="1">MAMKTGPKVALGSLLLLFVAAGAEVAWIHHRNHADDAPVAKAEYKSDPDDLVFLKKEHPDSLKDAKDLKGRTLWVSAGGQMDYFPYTGHKVDFAKSEGVLLGAEKLEVKDAIEAVAPKKTAFRIPAGDKQVLLVFTKAGAPTEYAVPVGYHEDGRYNFMTDEIFFYDDPHQLFNYWKPEIWAGIDAHKAVPGMNERQAEMALGQVVTPHGDTPGDRTMDFYNEGHPVTITFVHGKATTITPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD3</accession>
    <name>E8WXD3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0394</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578794.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0394"/>
    <dbReference type="EnsemblBacteria" id="ADW67466">
        <property type="protein sequence ID" value="ADW67466"/>
        <property type="gene ID" value="AciX9_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0394"/>
    <dbReference type="eggNOG" id="ENOG50336KP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2604845_0_0_0"/>
    <dbReference type="OMA" id="STHEARN"/>
    <dbReference type="OrthoDB" id="2070664at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="8485" checksum="E03B5258ED75EE2C" modified="2011-04-05" version="1">MDAFERFPIVELTDLRDELRSAGLDSWQAGELLTAFLAARGYGVSNDEARGAASRLEARGCSVPHIQRELESLAFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF9</accession>
    <name>E8WXF9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tannase and feruloyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0420</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578820.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0420"/>
    <dbReference type="EnsemblBacteria" id="ADW67492">
        <property type="protein sequence ID" value="ADW67492"/>
        <property type="gene ID" value="AciX9_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0420"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_4_1_0"/>
    <dbReference type="OMA" id="LTPMAKN"/>
    <dbReference type="OrthoDB" id="865015at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="PTHR33938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233961" evidence="6">
        <location>
            <begin position="20"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="55158" checksum="0DFB606E837E701D" modified="2011-04-05" version="1">MRSILIPLALLISSAAAHAATCASLAALSLPDTTITHAEAVPPGPLKPPYGDPIASLPAFCRVTGILRPTPDSEIRFEVWLPEKEAPKGKPAWNHRLLDVGNGGFAGTIAYGQMASNLRKGYATAGTDTGHQAEAEDASWAYHHPEKIKDFGYRALHLTTQRAKTILAAYYGEPQKKAYFDACSDGGREALMEAQRFPEDYDGILAGAPANNWTGLLSAGVDVSHTVIAHPEGYISSFKLRAINTAVLNACDAQDGLKDGLLNDPRTCHFDPATLLCKSGDELTCLTAPQVASLSKIYAGGHDSTGNPIFPGLMPGGEADWRDWITGGGPSESRYMLNFFRYMVYDDPAWSPLAAAVDASVRTAHEKMAEPLNATNPDLAPFIAHGGKLLLYHGWNDPAISPLNTIAYYQQVVAKVGPAQAEAAVKLYMVPGMGHCAGGPGPSGFGQIGLPSPGAGAIDQLQDWVETGKAPTSIIAAKYTADRKIQMTRPLCPYPQLAQYTGKGSTEDSTNFTCAAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN4</accession>
    <name>E8WXN4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1597</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579969.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1597"/>
    <dbReference type="EnsemblBacteria" id="ADW68650">
        <property type="protein sequence ID" value="ADW68650"/>
        <property type="gene ID" value="AciX9_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1597"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="OMA" id="THCENRT"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37447" checksum="F24B407DFFB12400" modified="2011-04-05" version="1">MAGMMKAAVYRDVDMVVCEEIPVPEIGAGEVLVRIDTCGVCGTDLKKIHTGSHAAPRVFGHEMAGTIAAIGVDVKGFSIGERVMAFHHIPCGVCFYCKKQTFAQCETYKKVGTTAGFEAAGGGFAEYIRVMDWIVAKGLVKVPDDIPFEQAAFIEPVNTCYKAIRMLNLEADDTVLVIGQGSIGVILAALAKRTGATVLTSDLYAERHKVAAGFGLDRPIDARGDVVAEAKKATSSRGVDVVLVAVGADSLITQAMDAVRAGGRVMLFASTQHGTAAYDPTAVCMDEKTLMGSYSASVAIQDEGVELVFQGFRDGSLDLTKLISHRFGLEDCAEAVRLASNPEPGSMKIVFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS9</accession>
    <name>E8WXS9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2750</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581089.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2750"/>
    <dbReference type="EnsemblBacteria" id="ADW69774">
        <property type="protein sequence ID" value="ADW69774"/>
        <property type="gene ID" value="AciX9_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2750"/>
    <dbReference type="HOGENOM" id="CLU_1882827_0_0_0"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230049" description="OMP_b-brl domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="3">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14362" checksum="69BE32EC3D645857" modified="2011-04-05" version="1">MNLRSRSVLVFAALLSFAPTLFAQAAYTATRSSRIQAGVAVMYLNSDYTDDGNKGLLFFGDYDFNRWVGVEADARLGGLISASDIGENSYSIGPRATYRRGRLNVSARSPSAAASSPIRSPRTLAPSTSSGTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT3</accession>
    <name>E8WXT3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2754</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581093.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2754"/>
    <dbReference type="EnsemblBacteria" id="ADW69778">
        <property type="protein sequence ID" value="ADW69778"/>
        <property type="gene ID" value="AciX9_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2754"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_0"/>
    <dbReference type="OMA" id="FERYGKR"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="33905" checksum="25806BA74B8A455B" modified="2011-04-05" version="1">MDLFQLETFLAVAEERSFSRAAARLHRTQPAVSQAIAKLEGELGEVLLERSSRDGTLTDAGEVLREYALKLLNLRNEAAGALTELRELHRGRLNLAANEYTCLYLLPLLDEFRRQNPQIKVAVQRTLASRIADEVLMHSVEIGVLSFKPDDVQVHSVMVYRDELALVVNPKHPLAKEGEVSIRQLGALNFVAHNIPSPQRQKVIQTFRRHKTPLNMGVELPSLEAIKRFVELGNGVALVPALVAQTELASGALVRVRVKELQLERKLRLVYRKQASLSHAALAFLRVVEAYAAAHGDPYAYQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY54</accession>
    <name>E8WY54_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1629</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580000.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1629"/>
    <dbReference type="EnsemblBacteria" id="ADW68681">
        <property type="protein sequence ID" value="ADW68681"/>
        <property type="gene ID" value="AciX9_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1629"/>
    <dbReference type="HOGENOM" id="CLU_1600386_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="17891" checksum="691E91D203C9B254" modified="2011-04-05" version="1">MTPNHHRAPDHGAPISNTPHSARAFTAEDGSSLVEFALTLPMFMLVVTGVLYLGIVLFNFITLTEATQFSARQMMISRGQTTDPCALFISTFYNSAPTLTHSNLTFSFSLNGTQYLSTTSCPAGVNNMVLGSEAIVLVTYPAKLALVGDVISPGFNLSDQELEQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY66</accession>
    <name>E8WY66_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1641</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580012.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1641"/>
    <dbReference type="EnsemblBacteria" id="ADW68693">
        <property type="protein sequence ID" value="ADW68693"/>
        <property type="gene ID" value="AciX9_1641"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1641"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_1_1_0"/>
    <dbReference type="OMA" id="VKAPRIM"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="34298" checksum="65F310962789E10B" modified="2011-04-05" version="1">MIAANVAEAYAFCRGVAKREAKNFYWSFRVLPKAKSDAMCAVYAFMRRADDIADDETMPVAQRRVVMAEWLAAWRLVRETGAGDDPVFVALGDAQRRFGIGDELLEDLVRGTSMDLEEGQGAAGGAVKLGDGLEGYETFEDLYRYCYLVASVVGLVCIKIFGYRDARAELLAERTGVAFQLTNILRDVKEDVERGRVYLPQSLLGEFQVSNGDVVALAGGREMRPNDRAMISALSVQAWEYYASARELLPLIDKDSRAALWVLVEIYSRLLQKIDARHGDVFSKRVSVPTGEKMMALVRGAGMAARNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF5</accession>
    <name>E8WYF5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2838</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581176.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2838"/>
    <dbReference type="EnsemblBacteria" id="ADW69861">
        <property type="protein sequence ID" value="ADW69861"/>
        <property type="gene ID" value="AciX9_2838"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2838"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035299_0_0_0"/>
    <dbReference type="OMA" id="ETRIAIC"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="408" mass="43896" checksum="FEC7B8072CE11229" modified="2011-04-05" version="1">MSPWLQQKLATYKHYSGGSLLNTQYLLFVVALAISAIQWFLADHASLLSTIIYTFVAGNVITIVLALAGPLYDQPFPRDWIVYTALLLPVAVLASTAGGVIDRLVLGMPLASLTNLRNGDIPFGTLVSIVIGLSIHAYASTRSNLEAANSQLSQEVHHGRRELEAQASELKAAFEIQSNLLPRTIPQIAGVEISCAWQPARTVSGDYYDVLPLSETRIAICLADVSGKGISAALITANLQATLRAFAPEEPSPANLCRRLNQALCASLPTGRFVTMAYGILDRRHMTLTYELAGHNSPILLRGKEVITLEGTGPVLGILPNATFEDHTIHLQPGDRLLLTTDGITEAFNPTNDEGGEEEFGESRVIAAAQSGQQTAHAIRTNIMTAVTTFAAGNFHDDASLLIVHLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF8</accession>
    <name>E8WYF8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2841</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581179.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2841"/>
    <dbReference type="EnsemblBacteria" id="ADW69864">
        <property type="protein sequence ID" value="ADW69864"/>
        <property type="gene ID" value="AciX9_2841"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2841"/>
    <dbReference type="eggNOG" id="ENOG5032XID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784733_0_0_0"/>
    <dbReference type="OrthoDB" id="1796378at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PTHR37536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37104" checksum="A1F9748BEF8AFD0A" modified="2011-04-05" version="1">MSDTVKVNIPQTPVATPVPITPQPGKFILDQGAFLQKLPFQAHPTPLPGVFTVPAPPSTLILATASQSDLIKAGIMFRQPTAQDPPGVQAAWKAFTSQHFDPAKRIIPEMAPQVGVTHNLKTPPTQVSNTSYNGTVWSGAGTKTGTWTTCIGTWVIPTVSKPSEAQGTEGGWNSSSWVGLDGFFYTNDVLQAGIQQHVNAAGVANYVAWYEWYAPIQAGSPSYVYQTNITNFPVSPGQTVSCSVQYVANHAGSISFSNQTTGQHFTITLAPPPGATNSGGSCEWIMEAPDGGEPKSSLPKFTPVVFTTALACGPNNTSTNPATGDTLNITTSSGKVLTKVTTGSDTCTISFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR9</accession>
    <name>E8WYR9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1707</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580074.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1707"/>
    <dbReference type="EnsemblBacteria" id="ADW68755">
        <property type="protein sequence ID" value="ADW68755"/>
        <property type="gene ID" value="AciX9_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1707"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_0"/>
    <dbReference type="OMA" id="TRFWRGS"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="230"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="458" mass="49539" checksum="CDFB96AAFCE16E14" modified="2011-04-05" version="1">MTRSLFFKLFVRLLFAAGVVFAIVTAFPDLPAVAVGGILLVWAALMALWTAHSLQRILGPMQASANSMIEGEQKPLTTGFRDFDGLAQALSTASKRVQGSLETAAESRRQLEALLDSMQDAVVAVDAAGRIQWTNERMQKMMLLPGGYFTGAVRVGHALVQTVRDPDVLECVRVALEDTAVAVRRSTSLVPGRIYEVNASPMPGGGAVAVLHDVTRIEEVERTQKDFVANVSHELRTPLTSITGYVETLLDHEAGISPQGREFLGTILKNATRMNRLTEDLLVMARVEAATVELSPAPVPADLLVREAVAGMKGLVQENEGVLEIGTITDCQVFADHDAVMQVLSNLIENAIKYGQPKAGGGTRVVISAREVAAPYDAVEFSVRDFGQGIASEHLNRIFERFYRVDKTRSRESGGTGLGLSIVRHMVQAQGGTIRAESELGEGSCFLFTLPKALYPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW7</accession>
    <name>E8WYW7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1755</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580122.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1755"/>
    <dbReference type="EnsemblBacteria" id="ADW68803">
        <property type="protein sequence ID" value="ADW68803"/>
        <property type="gene ID" value="AciX9_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1755"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104845_0_1_0"/>
    <dbReference type="OMA" id="VANYVGF"/>
    <dbReference type="OrthoDB" id="1956412at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="15578" checksum="A04C976B2D22CFF4" modified="2011-04-05" version="1">MSIEARLAELGLTLPAHPAPGGNYVPAKTIGNMVFLSGVVSSNTDGLITGTAGLDAGIEEGYAAARACVLSHLTVLKRHLGSLDEIQQIVSLNGYVNAVNGFPDAPKIINGASDLLVEIFGEPGRHVRAALGVNALPRNALVELQMTVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ09</accession>
    <name>E8WZ09_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2901</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2901"/>
    <dbReference type="EnsemblBacteria" id="ADW69924">
        <property type="protein sequence ID" value="ADW69924"/>
        <property type="gene ID" value="AciX9_2901"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2901"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120413_1_0_0"/>
    <dbReference type="OMA" id="YGDTKTQ"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230086" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="16818" checksum="B2DA9AF7C4922421" modified="2011-04-05" version="1">MKIGMSFAAALLAGAACVGAGAQVTVKHLQPNEKSAIADGVWAGDTLYLSGQLASPVTPADAATGKAAVYGDTKTQALSALNKIQALLKAQGLDMKDVVKMSVFLGGDPEKGGKLDFAGLQASYLQFFGTKDQPNKPARSAFQVAALAAPWALVEIEVIAVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ22</accession>
    <name>E8WZ22_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2914</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581252.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2914"/>
    <dbReference type="EnsemblBacteria" id="ADW69937">
        <property type="protein sequence ID" value="ADW69937"/>
        <property type="gene ID" value="AciX9_2914"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2914"/>
    <dbReference type="eggNOG" id="COG5485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_1_0"/>
    <dbReference type="OMA" id="HLEDWFG"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16993" checksum="849186CBE8491016" modified="2011-04-05" version="1">MSVNQPAVTSGLTAVEMQAIEKLYRAFNDRNPDLLDEACWPDWQDIPLAPGQEPGPDGLKKLMPYFFAAFPDLRIEIDEIIGESGKAGVRARIVGTHQGEFFGVAASQQPIEVRLHEFHHVREGRITHTWHLEDWFGMFQRLGTWPPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ86</accession>
    <name>E8WZ86_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0617</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579016.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0617"/>
    <dbReference type="EnsemblBacteria" id="ADW67688">
        <property type="protein sequence ID" value="ADW67688"/>
        <property type="gene ID" value="AciX9_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0617"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_1_0"/>
    <dbReference type="OMA" id="RSDCPGT"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233515" evidence="1">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="50"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="29414" checksum="73DE2B20EF60D7FE" modified="2011-04-05" version="1">MRGLVLAGLMLVSGVVWGQVPGTPDAPVQGSLTAEQQAPLNPALPTLFIVGDSTARNQADLGWGDHLAHYFDTTKINVANRARAGRSSRTFINEGAWDKVLAEMKPGDFLILQMGHNDGGDLDGAKPRGTLKGLGDEYKEVTLPDGHHEIVHTYGWYLRKYIREAREKKVTPMLMTLTIRNIWKDGQIERDMGYDAQLKDLAAQQHVLLVDMGTLEADGLQATGPEATALLFPKDHTHTSAEGAEMNAGYVVQALKAAHAPVDQYLKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC0</accession>
    <name>E8WZC0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ni_hydr_CYTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0651</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0651"/>
    <dbReference type="EnsemblBacteria" id="ADW67722">
        <property type="protein sequence ID" value="ADW67722"/>
        <property type="gene ID" value="AciX9_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0651"/>
    <dbReference type="eggNOG" id="COG4117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075520_1_1_0"/>
    <dbReference type="OMA" id="WHFFFAW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="4">
        <location>
            <begin position="87"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="35908" checksum="0C2A0D02ECB0BD40" modified="2011-04-05" version="1">MPEEPIAKEEGSPESVEEREAESAADAAVTSALAGAVPLAVGPERVVVAEAQRAADTESMPVEVAVAEEMAAEAPVAEPGIVLERKHPLAIRWMHWINFPVLFTMMWSGLLIYWNDSIPPYAHSHEVYRVGIGSWTLFRFFPAWFYTNKLWDIRYMPTTGLGYHFFFMWLFGVNGILYVAFLLISKEWKFMVPLKSSLRDAVQVTLVDLHLKKGLPPQTKYNGGQRIAYTSVIFMGLGSLLTGLAIYKPSQLHWLTSALGGYEMARWLHFLLTLGFCGFFLVHVGQVILAGWNNFRAMVSGYEIRRAEEPSLEAERGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC4</accession>
    <name>E8WZC4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBPb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1764</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580131.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1764"/>
    <dbReference type="EnsemblBacteria" id="ADW68812">
        <property type="protein sequence ID" value="ADW68812"/>
        <property type="gene ID" value="AciX9_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1764"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_3_2_0"/>
    <dbReference type="OMA" id="RNTTWTF"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233519" description="PBPb domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="33818" checksum="106EE6A1FE2DB8C9" modified="2011-04-05" version="1">MLPKLLIILATLSLPACAQSIETIRTTKLLRCAIDQEPPEYTTEDLHGPRVAFDLELCHAVALAIGPDIKVQPILVSDEAEAISVLKARHADLAPTLSLNLTNATTPGLWLGLPIVLDGTGFMVPTATLDVKSLSGKKICFFAETETETILKTWFTQNHLDFLPYPFSEEGEMDAAYTTGNCAAMAGDLTRLASTRQNYGRAAARYKLLPTLIASAPLAPASTDPTLTQLATWTNQLLLNAEALNITHIPEHSQDPAIQRLLGQTHELGPRLHLDDAWPIRVLTTLGNYADLYARTLPTVPLPHPTPLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM0</accession>
    <name>E8WZM0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ordered locus">AciX9_2971</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581308.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2971"/>
    <dbReference type="EnsemblBacteria" id="ADW69994">
        <property type="protein sequence ID" value="ADW69994"/>
        <property type="gene ID" value="AciX9_2971"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2971"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_1_0_0"/>
    <dbReference type="OMA" id="ARECEFL"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="16644" checksum="B963F75D9E0D324D" modified="2011-04-05" version="1">MINIDPPSSSLDVSSLSKSGLARFLNRAREAVGLDGEVEVLLTSDVEIKRLNKAFRGKNKATDVLSFPAPEEFEGVAGDLAVSLDTAAKQAAEHGHGLRDEVRILLLHGLLHLAGEDHETDSGEMAAREAELRKELGLPVGLIERVTAKGGRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS8</accession>
    <name>E8WZS8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0669</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579067.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0669"/>
    <dbReference type="EnsemblBacteria" id="ADW67739">
        <property type="protein sequence ID" value="ADW67739"/>
        <property type="gene ID" value="AciX9_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0669"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_0"/>
    <dbReference type="OMA" id="GNKKGWL"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="532" mass="57786" checksum="428B6B7981E5BBFB" modified="2011-04-05" version="1">MPDETHLEAEWKPKYNPWAIALTVTLATFMEVLDTSIANVALPHIAGSLGASQEEATWVLTSYLVSSAVVLPISGWLSNRFGRKRFYMTCVAIFTVCSLLCGLAPTLPILIIARILQGAGGGGLAPSEQAILADTFSVEKRGQAFALYGTAVVIAPAIGPTLGGYITDNFNWHWIFFINLPIGLLSLWLSNRMVEDPPKAKALTHIKAPVDFTGLALVAGGVGCLEFFLDKGQEKDWFGDPMICTVAAIAVFLLTFFVIWEWRHPDPIVDLKLLKNRNFGTAVFLQLILGMVLFGSTVLIPQYLQALLGYTAERAGMVLSPAGFVMMFGMALAGRSLSWRIDPRLTVCLGYMATAIGLYNLTRLSLDTSFGTATLWRMLQVIGLPFIFIPISTLNYVGVPRSKSNQISSLSNFARNLGGSAGTALLTTFLARTAQTHQNQLSANAVPGTVPYMQYMNSVAAALRHGGMSAAQSAQLAVGYGYQQMLRQASMLSYQNAFFMLAVSVFCLCPLPFLMRLPAKAEKPSPEEVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT8</accession>
    <name>E8WZT8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-(Acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0679</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579077.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0679"/>
    <dbReference type="EnsemblBacteria" id="ADW67749">
        <property type="protein sequence ID" value="ADW67749"/>
        <property type="gene ID" value="AciX9_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0679"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_0"/>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="175"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="27707" checksum="2B475E2000E58774" modified="2011-04-05" version="1">MSVHSTAIIEAGAVVPESCTIGPYCTIGKDVVLGEECELISHVVLAGHTTLGRGNKVFSFACIGIAPQDLKYKDEPTRVVLGDDNVIREYVTISRGTVGGGGLTTVGDGCLIMAYTHIGHDSSIGNGCILANSATLAGHVTVEDYAVVGALCPVHQFCRIGKYAYIGGGTTITQDVLPFSLTSIARDNHAYGLNKVGLERRGFTPEQLKELRGAYRLITAGKMNVSQALEELRGRIAAGEVGEHVKYLVEFVGKSERGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H3</accession>
    <name>E8X0H3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">AciX9_0768</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579163.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0768"/>
    <dbReference type="EnsemblBacteria" id="ADW67837">
        <property type="protein sequence ID" value="ADW67837"/>
        <property type="gene ID" value="AciX9_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0768"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_0"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="25508" checksum="673144B66E3A8034" modified="2011-04-05" version="1">MYKRVLLKISGEALAAGSGFGIDAIFIHKVAEEIADVHALGCEIAIVVGGGNFFRGVAQQAIDMDRVAADHMGMLSTVINSIALQDAIEKRGLFCRVMSAIEMHQVAEPYIRRKAMRHLEKGRIVIFAAGTGNPYFSTDTAASLRAMEIKADILLKATSVDGIYSADPKRDPKAVRYETISYDQILRANLKVMDTTAVSLCRDNNMPMMVFSMREQGNITRVVAGEPLGTLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P3</accession>
    <name>E8X0P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1948"/>
    <dbReference type="EnsemblBacteria" id="ADW68994">
        <property type="protein sequence ID" value="ADW68994"/>
        <property type="gene ID" value="AciX9_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1948"/>
    <dbReference type="HOGENOM" id="CLU_808367_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="36534" checksum="64B7FD532E62F0A5" modified="2011-04-05" version="1">MFGDGSGFVKARRAVLEHLADGRLTPTQFLIHHLLVLMADAKTGVASASAEKLVAYSGGQLVKRTVQDALMALEKKGYIKRKHIAGKHGNYPVFIDKYEVTVGSNAGRRVNAALSSDPVRPVMECGFCRTEETLSSDVEARGLESGGSGDRAETVLTPYRDRAETVPVQDLRLKNKEQTTTTAAPSGRVAGVAGLADQEQGQQPISYSVQQSDIHSLIEALYTAADKAPVHSAKNQAKAQGLLAARSLSQLLSFVAFSKADSFWGPKLKAAAHPVNYFASSLSSIEDQAVAARPRQRKPPSPAPPTAGSAPCPRCEGKGTFFSKTLGEDMPCGCQNVVRSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P8</accession>
    <name>E8X0P8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor SigS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1953</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580318.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1953"/>
    <dbReference type="EnsemblBacteria" id="ADW68999">
        <property type="protein sequence ID" value="ADW68999"/>
        <property type="gene ID" value="AciX9_1953"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1953"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675440_0_0_0"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="18102" checksum="73A02E4C945154DE" modified="2011-04-05" version="1">MTFTELNLHYSLYKSDHTRGHLLCEACRTYAKQLVGANNPDRHEIVADATHKAWTNFNMLPPDRVFAAWFTRIVRNKIRDYHRKARTRALNEEAAELYPESPFTLEQQQEMREKGGPLVSHLLNGYTLKEAADLLDISVRTAKNQLTKLSEEMNSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T5</accession>
    <name>E8X0T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3099"/>
    <dbReference type="EnsemblBacteria" id="ADW70119">
        <property type="protein sequence ID" value="ADW70119"/>
        <property type="gene ID" value="AciX9_3099"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3099"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_0"/>
    <dbReference type="OMA" id="FATDDYP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="31965" checksum="E327E4A9FCB0B1F6" modified="2011-04-05" version="1">MIENRHLRYFLEVARTLHITRAAERLHIAQPALTQNMQQLEQELGVELFERKGRRISLTEAGRVFEREAEHSLRVFLGAQLAAQRAVRGEVGKVVIGFQSTAGLTVIPHLLKQLGNKYPEIEVALREMGTSAQRKALRQGELDVAIMYTLPDDEFSHHELTPEPLVIALPESHPLAARDSIAVKELAKERFVLPAPEVAEVLYHAVLAECADSGFQPLHIQEVSTAQTALGIVSAGFGISILPAAIQALPRKGVVLKPIRNSRLQVQLALMWPADHASPIIPKLLECLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U2</accession>
    <name>E8X0U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3110</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3110"/>
    <dbReference type="EnsemblBacteria" id="ADW70126">
        <property type="protein sequence ID" value="ADW70126"/>
        <property type="gene ID" value="AciX9_3110"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3110"/>
    <dbReference type="HOGENOM" id="CLU_2897882_0_0_0"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="62" mass="6788" checksum="9615BA2916EECABA" modified="2011-04-05" version="1">MCYERNLGITPNFFPLIARSPDVSSAEANMHAILGKSLGHDTRERIQLIGLTPLPILPMKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W0</accession>
    <name>E8X0W0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fumC</name>
        <name evidence="5" type="ordered locus">AciX9_3130</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3130"/>
    <dbReference type="EnsemblBacteria" id="ADW70144">
        <property type="protein sequence ID" value="ADW70144"/>
        <property type="gene ID" value="AciX9_3130"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3130"/>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_0"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="33"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="431"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="52891" checksum="19448FD3AB9D76CC" modified="2011-04-05" version="1">MSMVEDTQVVDGHFKPGDVLEEGRWRIEFDSMGQVKVPADRLWGAQTQRSLIHFSIGNDHMPVEVYHAYGYVKKAAAIVNERLGLLPKEKSDLIVKSADEVIEGKLDANFPLYVWQTGSGTQSNMNVNEVISNRSIQLANGTVGAQDPVHPNDHVNMSQSSNDTFPTAMHIAAVKELKEILIPKVSALLTAIENKANQWQHIVKIGRTHLEDATPLTVGQEWSGYVVQIRSALKRIEAALPGLYQLAAGGTAVGTGINTPEHFGTKIAAEIAELTGYPFITAPNKFEAQGSLDGMVAAHAALRGLAVPLMKIANDMRWLASGPRCGIAELLLPANEPGSSIMPGKVNPTQCEAIVMICIQVIGDDTAVAFAGSQGNFELNAMRPIIINNFLHSARILADGSEKLRVFSVEGTEVNEKKVSEYVQNSLMLGTALSPVIGYDNASKIAHTAQDDGTTLREAAIKTGLIDAKKFDEVVKPHTMVGNTTLNFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X167</accession>
    <name>E8X167_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0865</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579258.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0865"/>
    <dbReference type="EnsemblBacteria" id="ADW67933">
        <property type="protein sequence ID" value="ADW67933"/>
        <property type="gene ID" value="AciX9_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0865"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046663_0_0_0"/>
    <dbReference type="OMA" id="NEISFWA"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="42698" checksum="BF59FE95832BDFC9" modified="2011-04-05" version="1">MPHSFASFFMGGFECATHKRRDGLQIDVLASTGHATHAARDYTLLAEAGVKTVRDGLRWHLIEAGAPGQYDWSSFLPMLDASIATGTQVLWDLCHWGLPHGLDIFSDDFVTRFEAFAAAAARLIQDRNPTPIPHYCPINEISFWAWVGGDVKAFAPHQEGRGPELKRQLVRASLAAIRAVRGVDPRARFLQPEPIIDIVPEWNDVEKYPHIVEQSRNHTASQYEAWDMLAGRREPELGGSAEMLDYIGVNYYWNNQWVHGGDRKPPGHPDHKPLHRMLVELWERYRRPILITETGAEMGADVGWLGYVAAEVRQARREGAEMVGVCLYPVMDYPGWDDDRHCRCGLIGVDEDWDVRSLRADLVEELRLQARITENVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H2</accession>
    <name>E8X1H2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3196"/>
    <dbReference type="EnsemblBacteria" id="ADW70207">
        <property type="protein sequence ID" value="ADW70207"/>
        <property type="gene ID" value="AciX9_3196"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3196"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537233_0_0_0"/>
    <dbReference type="OMA" id="EMVYGMD"/>
    <dbReference type="OrthoDB" id="252904at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234272" evidence="2">
        <location>
            <begin position="32"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="598" mass="65972" checksum="7D2FEE6AC4116483" modified="2011-04-05" version="1">MASTRVFYLPTTRHILTLCTAVFLAPLSAFAQGSSSSSNSEIRQQTQQQPSSSSAARTRRAEAAGAAVTLETNEALFTVATGLNACGYDDDLANSNPVRIEIRADVEAAIQASPAAAKSRQALCNYMSEHQLNDFGRQVAQYVSLGLYLSPPPALAPTADQLDMPPDALQVVNVLPLLRTFAEDTALHSIWIKHRPEYEAITARVHDPLTRIILDANIYIRVPVSTYDGRTFQVLVEPMLAPSAPNARIYATDYDIVTSPDTAGNIRLEQVRHLYLHYAIEPLVYSSASSMQRLTPLLKPVQAAPLEFIYKSDIVALLTECLIKAIEARTMDTGFTPPAKPKTRNVRAEEVQYNAALGVYERQAEQVRRRQVDLDMRQGWVLTDYFYGQMAQREHDSASLKEEMGEMVYGMDVGREQHHDEQIAFLPEGSGEFVRRVRPQPTGMMLAEELMMKGDLDGARDLAQKALTDPKQDHAEAEFVVARVELMEGDPETSLAGLKDVLATSKNPRTLAWAHIYLGRLLDIKTPPERTEAIAEYKAATNVPGVQPDARAAAQAGLKTAFIVPKTTHTEEEPVDPTGKAEKDAYKPDEPDPPAKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J0</accession>
    <name>E8X1J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3214</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581537.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3214"/>
    <dbReference type="EnsemblBacteria" id="ADW70225">
        <property type="protein sequence ID" value="ADW70225"/>
        <property type="gene ID" value="AciX9_3214"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3214"/>
    <dbReference type="eggNOG" id="ENOG50336BD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014756_0_0_0"/>
    <dbReference type="OMA" id="PEMETSW"/>
    <dbReference type="OrthoDB" id="1287410at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="30398" checksum="7DBD0E65CB3F9DE7" modified="2011-04-05" version="1">MTLMPALPKPDRRVLNLVAPLVPAADRPDWLRTWQAELWHLHNRANRRRRPATLVPDHYIGLTRDALWLRTDACRTALEGTPTLCLASLLACTVVATLAGLILAGSRQALLAYLSGPLNRSLVAAVIVTVVALATSSTRHTRPDAAPEPFIWLRRQLFFAAKILTTLVTVFFLSADLCLPIHPLLPNTADLLQVLSFVLLALVGIRWAVHDQQHRCKRCLHILATPARVGRPSHNLLEWNGTELTCKHGHGLLSVPEMETSWCSTSQWIETLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K8</accession>
    <name>E8X1K8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ordered locus">AciX9_3232</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581555.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3232"/>
    <dbReference type="EnsemblBacteria" id="ADW70243">
        <property type="protein sequence ID" value="ADW70243"/>
        <property type="gene ID" value="AciX9_3232"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3232"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_0"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="22231" checksum="56C92D3420565EAC" modified="2011-04-05" version="1">MNAAVPGRIEVVVGPMFSGKSEELIRRLKRARIARQRVACFKPDIDLRYHRTAIASHSSQTYEAVTVANVERLREELYPQLDGVDVVGMDEVQWFDPSIVGLVLELVHRGKRVVLAGLDTTFAGEPFGSIPQLMAIADEVAKLSAVCMVCGAPAIHTQRLGMSRELVVVGAAGMYEARCRGCFRPFLDEPEAAQLELPAVVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z2</accession>
    <name>E8X1Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2109</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580469.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2109"/>
    <dbReference type="EnsemblBacteria" id="ADW69153">
        <property type="protein sequence ID" value="ADW69153"/>
        <property type="gene ID" value="AciX9_2109"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2109"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_0_2_0"/>
    <dbReference type="OMA" id="TLFGAQH"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1055" mass="112981" checksum="BD326C6788CC36B2" modified="2011-04-05" version="1">MVEFFIRRPIFATVCALLIVLAGAVSLPTLPISLYPELAPPQVIVACNYVGANSSTVESAVTVPLEEAINGVEGMRYISSTSSNDGTSTITITFQTGYSLDIAAVDVQNRVATAQGRLPAVVNNTGISITKANSNFVLAAGFVSPDHSLSPAFISNYLDVYVSDALKRVPGVGAVVIFGERKYAMRIWLDPTKLAARGLTPLDVNNALGEQNIEVAAGQLGIPPSDPKQAYQMAVRVVGRLSDPRQFENIIIKSNAASGAGATNPVGTGIVLLKDVGRAELGAETYNTNLRFSGNDAVGLGIQQLSNANALDVDKRCRQVLADLEKSYPPGLKGIIAVDTTTVVSDSIKEVESTLAEAIIIVIVVIFLFLQDWRATIIPAVTIPVSLIGTFAFIKIFGFSINSLTLFGITLATGLVVDDAIVVIENVQRHLEEGVQDPMEATSIAMREVTSAVIATSLVLISVFVPVSFFPGTTGILYKQFSLTIAFSIAISAFNALTLSPALSAILLRKEQHKTGIQGFFLNPIDKAIKKLISWYAVAVTFAVKIRYAVLIVFFAGLAATAYEYTHVPTAFVPQEDQGYYLIIIQTPPGASLAYTAEFADRVSQVIRNDDDVFGTFSVMGFSLSGGSSPNSGLIFAPLKPVDERTKRGNGHSAHDIVLRTSPKLFGVPGGIAFAAEPPAINGIGTVGGFQFILQDGGRNTFGDIDRIAHQIVGQARSPSSGLTNLNTTFTANDPQIYVTIDRQKAEAIGVPLSQITAAMGTYMGSSYINDFDFNNRSYRVYVQADQQFRRNVQDLRQYYVRSNSNQMIPLDNLVAINETSGPQVINHYNLFRSAEIDGSPAPGLSSGQGNDNMVKLFEKNKLQGMTYSWTGLALEEVESSGKAIVIFGLGLLVVYLTLSAQYESFTLPFIILLAVPTAILGALGLVSLRGISDDVYVQIGMVMLIGLSAKNSILIVEFAEQQLGLGKSIIDAAITASELRLRPILMTSSAFILGVLPLYFATGAGAYGRHSVGTAIVGGMVLSTVLNLFFIPVLYVILKTFLATFTRTKPVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X262</accession>
    <name>E8X262_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3294</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581617.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3294"/>
    <dbReference type="EnsemblBacteria" id="ADW70305">
        <property type="protein sequence ID" value="ADW70305"/>
        <property type="gene ID" value="AciX9_3294"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3294"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_0"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="317"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="545" mass="60996" checksum="273FBA7B88F2015A" modified="2011-04-05" version="1">MISVSNVTMRYGSKLLFEDVSVTFTTGRRYGLTGPNGAGKSTFMKVLTGEIDAQKGTVVRPRKFGVLKQDQYEFDAYRVIDTVIMGNKALWAAMEEREIIYDKPDMTDEDGSRLGELEGIVGDEDGYEAEANAAILLQGLDIPDELHDRKMSELQGGQKVRVLLAQALFGNPQALMLDEPTNYLDLESIHWLQDFLLRYDGTVITISHDRHFLNAVCTNIADIDYETIITYNGGYDDMVLQKTSVRTRIESQNEQREKKIAQLNDFIARFSAGTRSSQVNSRKKEVERLATSELARSNIARPFIRFDMLRPSGKTVMECELVNKSYTQKDGKIEHVIQNFSAAVNRGDKVILMGRNGQGKTTMLKALLANGPGIEETDVSIDSGSVKWGHETSIGYFAQDHKGSIQLGMTASDWLHQFDPAATKEDIRGILGQMLFKGEEGLKKTDALSGGEAARLLFCKIMLQKPNILVLDEPTNHLDLESINALNQAIQKYEGTVFLVTHDQELIEEAGTRIWHFEGGPTNFKITDHKGPFEEYQQQLAMSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X265</accession>
    <name>E8X265_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3297</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3297"/>
    <dbReference type="EnsemblBacteria" id="ADW70308">
        <property type="protein sequence ID" value="ADW70308"/>
        <property type="gene ID" value="AciX9_3297"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3297"/>
    <dbReference type="HOGENOM" id="CLU_3200395_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="45" mass="5315" checksum="63DFA65829779EFE" modified="2011-04-05" version="1">MRRSNFGPWFASLPLTRFAFAYGATWAFALSMLPLGYRPFIYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X268</accession>
    <name>E8X268_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3300"/>
    <dbReference type="EnsemblBacteria" id="ADW70311">
        <property type="protein sequence ID" value="ADW70311"/>
        <property type="gene ID" value="AciX9_3300"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3300"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_9_1_0"/>
    <dbReference type="OMA" id="HVCAIPL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="33795" checksum="928DC79E3217FCBE" modified="2011-04-05" version="1">MKSGLSNSSMRLEDGCAVVVTYHPDQQVIENLVSLRLQTLHLVVVDNGSTADGLEMLRVAAGRVGFELIENGDNLGIATALNVGVRRALEMGREWVLLFDQDSCVTEGFVETLVAGYENSRWGDRLGLLVPRYVDKRFGTALPPNYVKEGLEAAMTSGSLLRAETFLRHGFFVDELFIDGVDYEYSLRLRAAGMVIDECVEAVLLHSPGEPQFHKLLGVLRFQTANYSPIRQYYQERNKIWIAKRYLIRFPVFCLKLFKFGAKNFMKILVAEEGKAKKCRFFLAGVRDGLLERMGKRLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X296</accession>
    <name>E8X296_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0961</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579352.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0961"/>
    <dbReference type="EnsemblBacteria" id="ADW68028">
        <property type="protein sequence ID" value="ADW68028"/>
        <property type="gene ID" value="AciX9_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0961"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064269_0_0_0"/>
    <dbReference type="OMA" id="FFDRRHG"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234106" evidence="1">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="37001" checksum="0DF731AB75CD0ED8" modified="2011-04-05" version="1">MRLIAALSLLLAATAAHAQFDLEESHTTASLRGVDALGDGVAWASGTNGTILRTEDGGYLWQPCTIPTGAEKLDFRGIQGFDANTAVAMASGPGTASAVYKTTDGCQTWKRVFTNPDAKGFFDNIHKVTSKQMYMMGDQVDGQFTVFFSPDRGDTWSIADDPGREADKGDGGFAASNSGLTAVGSTIYFVTGGSAVAHVYNTYGKCDPGAAQGASCPLAWQKTGLPLAAGNSASGAFSIAGRTTAGMSGKLSAVLVAVGGDYQKPDATAGTAAWSKDGGKTWTAATTMPHGYRSAVVFDSATQSWLTAGPNGTDISFDDGKTWKPVAGPTADSWNALSLPFAVGPKGRIGKLRAGVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F3</accession>
    <name>E8X2F3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="4" type="ordered locus">AciX9_2133</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2133"/>
    <dbReference type="EnsemblBacteria" id="ADW69177">
        <property type="protein sequence ID" value="ADW69177"/>
        <property type="gene ID" value="AciX9_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2133"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_0_0"/>
    <dbReference type="OMA" id="KGRNDVI"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="21952" checksum="5D2E7FEE8A19757C" modified="2011-04-05" version="1">MEERSWTVLAHLLRPQGRRGEVLAELLTDFPERFEDSLAVSLAKPGFSGTAGEARAATVTGFWLPVGKNQGRVVLSLAGIDSINLAETLNGLDVLIPRSDRMELEEGAEYIDDLVGCTVYDGDVEIGVVESVDFPTTPDGGRRLDDAAPLLSVITANEDEVLIPYVQQFLVSLDVDAKRIEMKLPEGLIELNLTEPKSGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I5</accession>
    <name>E8X2I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580525.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2165"/>
    <dbReference type="EnsemblBacteria" id="ADW69209">
        <property type="protein sequence ID" value="ADW69209"/>
        <property type="gene ID" value="AciX9_2165"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2165"/>
    <dbReference type="HOGENOM" id="CLU_2493544_0_0_0"/>
    <dbReference type="OrthoDB" id="1840229at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9305" checksum="8915B1C68EB0B913" modified="2011-04-05" version="1">MVVAKIIGEMLTWARTCAGLKIESLAEGSISVEMLTAWEDGTDKPSQTQAIAIAEKLGISYAMLFMPEVPPSDNPNTLDLRVSTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X305</accession>
    <name>E8X305_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheB methylesterase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1076</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579462.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1076"/>
    <dbReference type="EnsemblBacteria" id="ADW68139">
        <property type="protein sequence ID" value="ADW68139"/>
        <property type="gene ID" value="AciX9_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1076"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_0"/>
    <dbReference type="OMA" id="PGYHLSV"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="224" mass="23375" checksum="2444981431AC6790" modified="2011-04-05" version="1">MKISAGDGRKTPGALEIVVIGVSTGGPSALEVMLPGLPKDFPAPVLVVQHMPRLFTGSLAERLDRLCPLRVREASGGVEVKAGTIWITPGDAHMEIARGFNGLTVSLHQQAMLNSCRSSVDYLFRSAAEVVGAGTVAVVMTGMGADGLEGARAVRHAGGRVLVQDEASSAVWGMPGRVMQAGLAEAALGLDELAAGLMKRVVGQGQEEASVVSVERRQERFYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C2</accession>
    <name>E8X3C2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="7" type="ordered locus">AciX9_3417</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581735.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3417"/>
    <dbReference type="EnsemblBacteria" id="ADW70423">
        <property type="protein sequence ID" value="ADW70423"/>
        <property type="gene ID" value="AciX9_3417"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3417"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_1_2_0"/>
    <dbReference type="OMA" id="MACEAWE"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="7917" checksum="5E7A5277EAD7633F" modified="2011-04-05" version="1">MAEIRVQEGEPLENALRRFKRKVQTEDIIKEVKRHSFYLKPGEKKRVKEALARKRNRKKVRKEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F3</accession>
    <name>E8X3F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3449</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581765.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3449"/>
    <dbReference type="EnsemblBacteria" id="ADW70454">
        <property type="protein sequence ID" value="ADW70454"/>
        <property type="gene ID" value="AciX9_3449"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3449"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075843_1_0_0"/>
    <dbReference type="OMA" id="RYLGGPW"/>
    <dbReference type="OrthoDB" id="1767754at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19435" checksum="3FBC3C2F0B044A7B" modified="2011-04-05" version="1">MEAQVAAHSNASYILTLALDPASQDLFDRLRKAHYPPKLNQIAAHLTLFHKLPQTEAVQAYVASAAVQESFTMRVTGLRSLGRGVAYSLHSDELQAIHRQLSTGFAEHLTAQDKQKFWPHVVVQNKASGEEARELKLKLELEFREFDVQATGLQLWRYLGGPWELAATYTFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H5</accession>
    <name>E8X3H5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579489.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68166">
        <property type="protein sequence ID" value="ADW68166"/>
        <property type="gene ID" value="AciX9_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1103"/>
    <dbReference type="HOGENOM" id="CLU_2246175_0_0_0"/>
    <dbReference type="OMA" id="WANGEIH"/>
    <dbReference type="OrthoDB" id="2190457at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="13389" checksum="F1575C909152C050" modified="2011-04-05" version="1">MTPPQYDDWIATSATVTTCRFQFARMNTFTLGIQTQDKFRITFDYYAHGRLYSDEFQSPKAIPQNTEIPILYNPHAPEQNNRTSGPTATPTRTPIMAVGIAGSIILSLAWLLILRGCHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I8</accession>
    <name>E8X3I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1116"/>
    <dbReference type="EnsemblBacteria" id="ADW68179">
        <property type="protein sequence ID" value="ADW68179"/>
        <property type="gene ID" value="AciX9_1116"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1116"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_11_0"/>
    <dbReference type="OMA" id="MGLCDGV"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="215" mass="23640" checksum="CF443DE82F305202" modified="2011-04-05" version="1">MRYAEDVAKAIKQRLTRQESRLETRTKLLESAAQLFARGGYEGASVDLIAESAGYSKGAFYSNFESKEAIFLELLDIHKRREIDALAALLAQDIPASELLSLIRSGESGRGSDFRIGLLSAEFQLQACRDKTFAKTYAKLHRTHRDTMAGLVVKLFAKLARTPPSAPKDLADIIMGLTTGLSLQETSVQGPLRKGFINEAILLVLGLDRVGEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J6</accession>
    <name>E8X3J6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1124</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579510.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1124"/>
    <dbReference type="EnsemblBacteria" id="ADW68187">
        <property type="protein sequence ID" value="ADW68187"/>
        <property type="gene ID" value="AciX9_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1124"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885463_0_0_0"/>
    <dbReference type="OMA" id="ATRYDPN"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="36"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="36206" checksum="D127239F64061A7A" modified="2011-04-05" version="1">MLNRRQFATLGTATAASLLTQRLWAQQARKDPNKFYFALVADSHIIDDFYVKGSENGVEDNESILLTTPRLVSARDLINSLNPAIEQVFLIGDYFHNYPSTDYDFYFKNTTRLDHAKTITDGFKMPVHLGFGNHDYDVHRVPREMSNRLFKAKFNAEPYSVLDYKGYKFIHLNNFLGSTQDNTAADFDPRRGSLGETQLHWFEAQLQQHKPTFVFIHYPLDLDQPTEFADYGLYPLLQKYKDTIQLVVSGHKHKWIDSAHTYGPQHYTMAATRYDPNAYMLMEVDTKANTWRFMNESLVEWSTHYAKPYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M0</accession>
    <name>E8X3M0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1148</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579534.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1148"/>
    <dbReference type="EnsemblBacteria" id="ADW68211">
        <property type="protein sequence ID" value="ADW68211"/>
        <property type="gene ID" value="AciX9_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1148"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_0"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="395" mass="42845" checksum="6E1784068CACD299" modified="2011-04-05" version="1">MLDFSRQFAAIREEVMAAIEQVCVSQRFILGPEVTTFEQSAAAACHVPHAIGCASGTDALWLALAAAQIDQPTQSVITTPFSFFASASSILRAGARALFADIDPLTYNLSPASVAEVLATCPAGEVKAILPVHLYGQCADWDAFTTIQNQHPGLLLIEDAAQAFGAAWQSAPAGTGSDGTLTPAGALGDAAAFSFYPTKNLAAFGDAGLMTTRSPQLEERARMLRAHGMRRRYFHDEVGWNSRLDTLQAAVLEVKLRYLPQGNQRRRDLAANYNQLFLAAGIATMPTPTNPTTIADGVVLPYTHPRAQHVFHQYVIRAPRRDALRTHLTAQGIGTEVYYPLPLHLQEALKPLGYKPGDFPESECAAAEVLALPIYPELREDEQQTVVEAIHTFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M1</accession>
    <name>E8X3M1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hfq</name>
        <name evidence="3" type="ordered locus">AciX9_1149</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579535.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1149"/>
    <dbReference type="EnsemblBacteria" id="ADW68212">
        <property type="protein sequence ID" value="ADW68212"/>
        <property type="gene ID" value="AciX9_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1149"/>
    <dbReference type="eggNOG" id="COG1923">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113688_2_1_0"/>
    <dbReference type="OMA" id="QQMVYKH"/>
    <dbReference type="OrthoDB" id="1989988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="10936" checksum="6AAB10318EF87C53" modified="2011-04-05" version="1">MDSKPAQNIQDTFLNTVRKDKSPITIYLVSGVKLTGKIRSFDKYSVLLENNSQEQLIFKHAISTVVSGRAGMHTDGRPESRPHSATVGGHIGGSAEPATAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M3</accession>
    <name>E8X3M3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="16" type="ordered locus">AciX9_1151</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1151"/>
    <dbReference type="EnsemblBacteria" id="ADW68214">
        <property type="protein sequence ID" value="ADW68214"/>
        <property type="gene ID" value="AciX9_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1151"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098238_0_0_0"/>
    <dbReference type="OMA" id="ANMEADI"/>
    <dbReference type="OrthoDB" id="1832177at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230201" description="ATP synthase subunit b" evidence="15">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW68214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="25492" checksum="486E33602D8ECAC1" modified="2011-04-05" version="1">MSKMMNRIASIAALAVLTLGLCAPVYAQAMKADDSGRQTTPAANSNEANQGEVDETAEYKQSAVVKKLGGMMGMKPAQAALLFEVINFGILAVLVGGFLLKALPKAFRNRTTLIQKHLVDARTATEEASARMSSIEDRLAQLDGQIATMKTQAETTLAADEQRMKVAVEEETAKILASAEQEIAAATQHARKQLQAHAAELAIEQAARKLTISAETDRLLVQNFARRLAGDDVKGGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N1</accession>
    <name>E8X3N1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1159</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68222">
        <property type="protein sequence ID" value="ADW68222"/>
        <property type="gene ID" value="AciX9_1159"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1159"/>
    <dbReference type="eggNOG" id="ENOG5033Y5K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868584_0_0_0"/>
    <dbReference type="OMA" id="IAYNRIT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230635" evidence="1">
        <location>
            <begin position="29"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="34862" checksum="DFD53257A21D5B03" modified="2011-04-05" version="1">MMRSMKSVLRSSALAALVLMLSGSTVHAEVGGAEAREAGAIREVKAVYGLPGIAANADGVLSFSLRTMRFTTDQGSYEIERQRIVGVSDGDERVESFGTKGRVVRMLIPYGGGFAVAAVAHKKVGLLTIEFTDAAGDYHGAVFVLNTDDMGTALGQLDVHPPSLYAPALAPVACPASKVRADTVRVEEIGAELQSDFPAEDRVLLYEHLVERLKSEKSIEAVYRAGGTRTAGECAEFTVTVRAEAFKKGDQAVRASLGPLGHFVGTTKLNYHLTVRTQDGTAIVDQEMKKSEGSDSDSLNVTKAISKAVVKSLKKSRKELRKTQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P3</accession>
    <name>E8X3P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2283</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580637.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2283"/>
    <dbReference type="EnsemblBacteria" id="ADW69321">
        <property type="protein sequence ID" value="ADW69321"/>
        <property type="gene ID" value="AciX9_2283"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2283"/>
    <dbReference type="eggNOG" id="COG3127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009475_3_0_0"/>
    <dbReference type="OMA" id="LIMWRLS"/>
    <dbReference type="OrthoDB" id="127265at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="299"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="771"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="865" mass="92369" checksum="90FAC3EF0941E203" modified="2011-04-05" version="1">MPSLSYPTAFRIASREMRSSRGKFFFVILSVAIGVAALTGVRGFSNSFRTTLLTRARSIMAADLSARTNQQPTPSEAEGLATIEREGVQMTPVTELLSMASAAKTLDPLLISLKAVDPSAYPYYGTVDLEPTSTLQQVLTPDSVVVADDLLVRLHLQIGDQLKIGNKLFRIASVVTNEPDRLSSQFAAGPRVLISRQGLDASGLLAPGSHAGQRFLFKVPAPANGAPISDAAVADLKARLIKLLPESQITDYRETNPALTAGLDQATSLLSLMSLVALVLGAVGVAMAMRAHLQQRLDTIAIMKSLGAGSGQIIKIYLIQTLLLGLAGGVVGVGLGVGVQLAFPYLLASLINVRPELHLDLRAIAAGLGAGVLTTFLFTLPPLLDIRGIRPILILRRAVDETDEPWHVKLVRLFTKNLAQIGAFLLILAGLALIAFRISDSASVGKWFTVGLAAVLAVLLLASFLVLKALKFFLTRTRLHLPSAVRHGLANLYRPGNPSSALLAALGMGVMQIMMVFLMQNAVVKQLHISSAPNLPNIFLVDIANDEIDGMRKLLTSAPGITAPPELLPVVSSRILAIDGVSANDIKTKNFPKHMLRSIQLTWAEAVPPGATVASGKWWTKAQSAAAADHPVVAVADFQAKRLGLKIGSVITFAAQDKQFDATVAAFTRSDGQHAYSRAEFILPERALTGLPVIWYGGVHVDPTKVAALQRALYAAYPTVTVINVAQALETIRAVVIQIIYVVQFLAAFSIFAGIVILASSIAGTRYRRIREVVVLKTLGATRAHIASIFSIEFAVLGLVAGLVGVFFANIVVKGLLRALTVPNTFQWGWSLGGLFGTAILTVATGWIASHRILGQKPLEVLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T9</accession>
    <name>E8X3T9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2330</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580683.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2330"/>
    <dbReference type="EnsemblBacteria" id="ADW69367">
        <property type="protein sequence ID" value="ADW69367"/>
        <property type="gene ID" value="AciX9_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2330"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346441_0_0_0"/>
    <dbReference type="OMA" id="NRGHYFG"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230650" description="Cytochrome c domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="414"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="686" mass="75847" checksum="8DE017906EEAAD73" modified="2011-04-05" version="1">MRAGRVLVFTTLLLLLTASLGAHLHRTRAQTGYVCPDGSTNCYQMSYVGLTDLQRQGRDTWYFWTGGDRNPGGTNVVGDQALWRHIATETHGQFDLIQSIDSRHRGQRFKQFGIISDPDCRKASAPDQYGLWIDDCTSINTPPLGPAFGKSAGIIGLRIFPNPNFDPKKWNVDAYRKDAASVEPPYLVGMTCAMCHVGFNPLHPPADPENPQWHNLNPGIGNQYFREQIFSAAKFPMTQSLQPNDFRWQLAHSEPAGTSETSQVATDHIFNPNTINHIAYINDRPTHAEVTADGVHRNVYHILKDGSDSVGSACLDDPTPHPGQDDTACAALRVYINIGVCANIWTTLQDPIYGLQRPQSAFDPKQARLDPNCNQGWTDTEARMGGLESFLRTLAPLHLADADNGQAYLPKDTAVLTRGKAVFAEQCASCHSSKRPPADNATTQAEWFRQAVMADDFLQKNYLSDDARHPISEIKTNSARAMGTNATAGHIWANFSSDTYKQLPPVHIDGLVDPFHTSLKLLPFEATGGRGYYRTPNLANIWATAPLLHNNSVGLYNGDPSVAGRLAAYQDAMEKLLWPERRPGVKSIQRTSQASKFFYEEGGSVCIAKGTPVSLIANVDVVTPEHFRKDDFFTRFFCKVTGTGHLNALFLLADNAPDFVQDRGHTFGAELPDADKKALIEYMKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X0</accession>
    <name>E8X3X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3473</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3473"/>
    <dbReference type="EnsemblBacteria" id="ADW70478">
        <property type="protein sequence ID" value="ADW70478"/>
        <property type="gene ID" value="AciX9_3473"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3473"/>
    <dbReference type="eggNOG" id="ENOG5033EIF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3099378_0_0_0"/>
    <dbReference type="OMA" id="MANTKSI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5649" checksum="8E72371BAF81FEC3" modified="2011-04-05" version="1">MANTKAITDTEERKKIKRAARKKAAPKAKRTGARGENKAKIKKAARGQSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X474</accession>
    <name>E8X474_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0043</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578463.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0043"/>
    <dbReference type="EnsemblBacteria" id="ADW67134">
        <property type="protein sequence ID" value="ADW67134"/>
        <property type="gene ID" value="AciX9_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0043"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_0_0"/>
    <dbReference type="OMA" id="KNIPHSW"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="18880" checksum="D35C86319B5819D5" modified="2011-04-05" version="1">MAEATAVPADDLQRYLKLAQPDGDVKLPHLGVVGDTYTLLLTGKDTAGRLSLIDMHVPPGGGPPPHRHDFEETFIVLDGELSAIFRGQKMAVKAGETVHIPSNAPHQFHNSSDKPVRMLCICSPAGQEEMFLEIGVPVATRTTAPPPLSEDEQKAFRAQAEALAPKYKTELLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A8</accession>
    <name>E8X4A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22 glycoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1172</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579558.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1172"/>
    <dbReference type="EnsemblBacteria" id="ADW68235">
        <property type="protein sequence ID" value="ADW68235"/>
        <property type="gene ID" value="AciX9_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1172"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_1_0"/>
    <dbReference type="OMA" id="MAYLLMN"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="21837" checksum="5C364D87F41E1E9C" modified="2011-04-05" version="1">MAYLLMNTCGLEGVVALAADGVMRVEVLPGRGTSEHLMPAVRRVLEGFKVGELAGVGVVVGPGSFTGVRVGLSAAKGLCEAGAVGMVAMSRLALVAAALGEAEGDVVALLDGGRGEFYCGVYRGGERVWERLILREEADRLVAEGVAVTCEARVAEVLGERVRLVREAGAEEMLAMVVARGKAGDWSDVAAVDANYLRRTDAEILVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B2</accession>
    <name>E8X4B2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1176</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1176"/>
    <dbReference type="EnsemblBacteria" id="ADW68239">
        <property type="protein sequence ID" value="ADW68239"/>
        <property type="gene ID" value="AciX9_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1176"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_2_0_0"/>
    <dbReference type="OMA" id="IFFDFFD"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30660" checksum="AAAE4B124A43AB42" modified="2011-04-05" version="1">MANAGAEVIQQETGSAPVRRRPSRGMYVLPSVFTAGNIALGFYSLTQSIQGTMGNNAGFDHAALSIGFAVLFDGVDGRVARMTQTTSDFGKELDSLADVVTFGVAPAVLAYVWGCRMLPVNAMPKLRETVLALGVVVCFLFLICGACRLARFNISINPQPKNPGRPGSKYFVGMPIPAGAGVIAAVIHCFDGSPIYDPRISIVWLLLICGTGYLMVSSWRFWSGKEIDAGSRKPFQTVVLLALVIAAIWMFSEITLMIIALGYLVSGVVARLAYSWGRSRRNAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C0</accession>
    <name>E8X4C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1184</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579570.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1184"/>
    <dbReference type="EnsemblBacteria" id="ADW68247">
        <property type="protein sequence ID" value="ADW68247"/>
        <property type="gene ID" value="AciX9_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1184"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009182_0_0_0"/>
    <dbReference type="OMA" id="LQCLWKH"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="91"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="517"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1178" mass="132004" checksum="B10EF550EBC70A07" modified="2011-04-05" version="1">MDKPVFYDPQRKRWKRLRRIFDVLAAFGLFLGIIFVFGLWRMKPLPELRLTPQTRNYHALVTPPKATLKPKSAHRKTTLKPSEIPLNSGEGLRAAYYVDDDAASYSSLKEHIRQIDLLFPQWLHVISPDGGLTAYTAGDNRPFAVVDKNGAHGVDQENKVARAIQLNHADMEVFPLVDNYDSVKQAYFPGLEDFLQDADARNNFVHQVDVFLAANSGYRGLTLDFEDVTPLGQPGFKALIAALYADFQAKKLKLYLNTPIENPDFDLAYMAAHSDGLLLMDYDEHQSTTEPGPVASQDWFTDNLARVMKTVPKDKIIVAVGSYGYDWTTTMPAEGAAAKKGRRATAAAPLKVVSASTIKTQDAWQGASDAGAEVELDGDSLNPHFAYDDDDAHLQHQVWFLDAVTVLNEMRAVRSFGLQTFALWRLGSEDNSLWKIWDTPTRVDPLKVLTTVDPGYSVDTEGDGDILRVIRKPQSGTRALTLDDDDQVPVPLKMVTKEQMVSYPLPYTLQQYGYQAKKVAITFDDGPDAEWTPKILDVLKKYGVKGTFFMIGEVAQDNVGVMQRVYREGHEIGNHTFTHPDISEISNTSVDLQLKLTERLFGSKLGVQPLYFRPPYSIDQEPDTNDQAAPVDRIQGLGYVTIGNKIDTNDWDEHPRKSPQEITDSVLQQLADMEAHPDRRGSIILMHDGGGDRSATVAALPMLIQALRAHGYQIVPVSELMGRTRVEVMPALTSKQRWQARADSVTFFFFSFFNHLVIYVFYLGDILMSARLIIIGVFATIDRFRKRKNYATADYCPKVAVLIPAYNEEKVIARTIRSVMMSNYKNLRIVVIDDGSSDKTYQTAIDAYPADIASGRLEVITKPNGGKADALNFALENIDEEIYVGIDADGVIAHDAITNLVPHFANPKIGAVAGNAKVGNRVNLWTRWQALEYITSQNFERRALDLFDVVMVVPGAIGAWRTAAVKKGGGYHSNTVAEDADLTMNLLEQGYSVIYEDRTLAFTEAPVNANGLMRQRFRWSFGILQAVFKHRGAIAKHRAMGLFALPNIVIFQIMLPLVSPLIDFMFVAGVIHYFIDKHFHPDTTSTGNIYKLLTFFLAFLVIDFAASALAFLLERKHPASKGDGWLLFHIWIQRFSYRQVFSLVLLKTIKRAIDGKSFSWDKLERTATMSKATDKIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F7</accession>
    <name>E8X4F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1221</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579607.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1221"/>
    <dbReference type="EnsemblBacteria" id="ADW68284">
        <property type="protein sequence ID" value="ADW68284"/>
        <property type="gene ID" value="AciX9_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1221"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_5_0_0"/>
    <dbReference type="OMA" id="PIFGTTH"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="233" mass="25404" checksum="6FCA84DB8E19094E" modified="2011-04-05" version="1">MLLKELREEVLEANLELVRRGLVLYTFGNASGVDREQGLVVIKPSGVDYDDLKPEHMVVTDLDGKIVEGTLRPSSDLDTHTLLYREFTEIGAVVHTHSEFATSFAQAGLAIPAFGTTHADYFYGPVPVTAALTDEAISGRYVHETGLAIVERFKGEHPLDPLAVPACLVNGHAPFVWGRTAHDAAHNAVVLEAVAKMAYRTLTLQADVLGVSQALLDRHYFRKHGSAATYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z2</accession>
    <name>E8X4Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578513.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67184">
        <property type="protein sequence ID" value="ADW67184"/>
        <property type="gene ID" value="AciX9_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0096"/>
    <dbReference type="HOGENOM" id="CLU_1174080_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25834" checksum="681AF0523A2AA26B" modified="2011-04-05" version="1">MTQVVPKLAQEEPVSQREQKLVWLQFAIGAVTLVICAVAAFVIYPSFHKAKQAEITQAATAVRAESSLAALSSSTLQRIQQLDAQSNALTTSEVPELYFWKGGLQKSTLSSEAVAQLSRILIERRFLIGDSAPLLNYSLPLKNYVCGHFWFVIATSPGNVEDTRRALLSLRQRDPRFTTAETIDSGPNNPANGIAIGFFTSQEDAVALTREIGVPAFEAKRWGFAPNEAQCPIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X521</accession>
    <name>E8X521_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0137</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0137"/>
    <dbReference type="EnsemblBacteria" id="ADW67213">
        <property type="protein sequence ID" value="ADW67213"/>
        <property type="gene ID" value="AciX9_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0137"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="RIWDSKV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="26524" checksum="6CE30EA2578C0D0A" modified="2011-04-05" version="1">MHSPPSTRKAAKMSGLSGKISLVTGGSRGIGREIALALAKAGSDVALIGRTAGPDAYAVVDEIRAMGRQAFVYFADLSKAAQAASVVQQAASELGPISILVNNAGINPSKPLEQISTEDWDETIAVNLSSAFYVTQAVLPAMRAQRWGRIIMLSSVAAQLGGVIGPHYAASKAGIIGLVHGYASLLAKEGITVNSIAPALIETDMLKGNDRIKPTLIPLGRFGTVDEVASVALMLAENGYMTGQTINVNGGWYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X536</accession>
    <name>E8X536_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0153</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67228">
        <property type="protein sequence ID" value="ADW67228"/>
        <property type="gene ID" value="AciX9_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0153"/>
    <dbReference type="eggNOG" id="COG1462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533974_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="510" mass="52835" checksum="C0D88D12441A8184" modified="2011-04-05" version="1">MDAVEYPRSYARPGRGLVTLHGRAKTGRGIAIGLGVSLALTASLHAQDSASYYEFGTVVALGQRSVEVQTSDPQRPRPVVHTFLLTRDTRADLVHIGDSVEVIYSPSGADLVLRRVVLLLAGIPKAGPPAVETAAALPSAPPPSTVRPTTPPRTSRSNGKNKPVVPPVTHAAVALPPAPPPAAAPSRAGNALNLGNPNALHAAPLTNVPLGVPASATVKLNAPGSRAIAHDAPGAECNRGSADWPAQPLSIAVLDFRYPTEREESHDIGTTGGGAGTAVADLVFNRLGQLQEFQMQRGDRRRLDRTDIAGAARLGRQLGVDAVLAGTFQPVPLPPGAEDDPYRPPTYELRAGLVDTCTGQVLMKLSSDVCAENGGKGNGCVPPSITAKQASNPEANAGAFAVPMNALLAPLEHNTTPQAQPPMAGVVLGATDVAVTLRVTSPAQVRVGEELAVHATRLAKNPTTYTLNILRDQEIGRIVIKSVQGATATGSYTGDIPAKAGDQVESLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X582</accession>
    <name>E8X582_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1284</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579669.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1284"/>
    <dbReference type="EnsemblBacteria" id="ADW68346">
        <property type="protein sequence ID" value="ADW68346"/>
        <property type="gene ID" value="AciX9_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1284"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_4_1_0"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="28234" checksum="3F903B97F015CC59" modified="2011-04-05" version="1">MRRRWIADHFTPATGHPTHAALTGDQAAHLARVLRAQPGQIFDVVAAGFLHRAEITAVSPERVDFLLHEELESDSALPLHLYLAIFKFDHLEWAIEKATELGAAKITPILARRTEKHLAQAAAKRVERWRRIAHEASQQSRRTSTPEISDPTPLKQALERETAPHRILLSETEQSLTLSTALGAPRLDSETWDGIPSNSQEITHALAIGPEGGWTPEEMSLFTHHQWTHVTLGPRILRAETATIAAIAIAGTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C8</accession>
    <name>E8X5C8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2440"/>
    <dbReference type="EnsemblBacteria" id="ADW69475">
        <property type="protein sequence ID" value="ADW69475"/>
        <property type="gene ID" value="AciX9_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2440"/>
    <dbReference type="HOGENOM" id="CLU_216829_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5151" checksum="EE05BA204711F5F8" modified="2011-04-05" version="1">MIVVQEIAGRGEFNMWDVGCVIACVVFFLIAIAYTRGCERLATKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D4</accession>
    <name>E8X5D4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580797.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2446"/>
    <dbReference type="EnsemblBacteria" id="ADW69481">
        <property type="protein sequence ID" value="ADW69481"/>
        <property type="gene ID" value="AciX9_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2446"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298406_0_0_0"/>
    <dbReference type="OrthoDB" id="125814at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045392">
        <property type="entry name" value="DUF6519"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20129">
        <property type="entry name" value="DUF6519"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108465" checksum="A2601501ED531A4D" modified="2011-04-05" version="1">MPGDFSRSSFNWPQRYSGVLMQQGRVQLDADWNEQVALAQHRTDAEAYDTIGVCGTPKTGSGFKLQLTPDGQDLLIAPGRYYAGGLLCELDPEWLPLAVDGTSFKLVSAFTDGRRWRSGDWAEVRRGTDASQFLKIGEIDEVTLDVNFTTSLNAGDSGSIAIRRAYTYLTQPFFPQPEFPTAAPTSPPNSPPNSPPSSPPFSPPFSPPSSPPQTVLPEGEYLAYLDAWQREVNWMEDGHIREVALGKPDTAVRIQTVWQLKLLNITDDVSTYLQTGKKPACNVFLPSWGTLLAGARTTGLLNARAVPLPPEANPCSLPPDAGYLGMENQLYRVEVVQGGPTLAGCTFVWSRDNGSVETSVVSVSPSSPNQVTVTDLGDDDLHALEVGDWVELVSRDDELQNTPRFFAQIVAPAPDPSLNVITLSLPVPDPSRIGADESNDFRLRRWDMLGASVTPNGIAVVDGWLDLESGVQVQFMEGSFASRDYWLIPARTITADVEWPPFEQPNTSPVPQPPIGPHHYLCRLALLASTNGDVSVQDCRTLFPALTAICADDVCYHSSCDALKEANTVQKALDALCNGLQLNFHKKYLHGWGVVCGLEVACAGDGASVTVDSGYAIDCQGNDILLRTVASFNVLEHISTPSGSPDADYSLYFDTTASNALALEPYTAPKNPLQAALEGTFWSDYFTSYLQPFVDIFKDLGTQPSNALVRNDERSLSSLIDLLFQQIDPSFGSNVYISLDEHNLLTSLYDTVRKRIRDRTLCSLFADVPASLPAYPDLIGGIQTGFGEKAKTRLRVNVAGTFAVASGGDTTIHLYDLRGTAPLLVQRFTFPASGTQAVNDCVFLSGDTQLFAIASDGTNTTLGSIPFQTAGATWVTQALAGVSLDSLAVMNALLVASCPNKGLYTAQISTQPVQLAGPAISCSCLGPMTTNGNQLFVPCTDPATGVGTIINEYAVDGNLVHVDSITLPTGLSMTHQDDLVVGPGNFAVYLYYSADGPNAQRVISAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D6</accession>
    <name>E8X5D6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2448</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580799.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2448"/>
    <dbReference type="EnsemblBacteria" id="ADW69483">
        <property type="protein sequence ID" value="ADW69483"/>
        <property type="gene ID" value="AciX9_2448"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2448"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003211_0_0_0"/>
    <dbReference type="OMA" id="WNALRPR"/>
    <dbReference type="OrthoDB" id="109272at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="905" mass="94935" checksum="F0D703C5CF9A1F52" modified="2011-04-05" version="1">MSCGDGCTCGCCAGLAAVTPVAVENRPGLPALRYRVGTYADFRETLFARISQSHQPVLSALSTRDDDDFTIALFDSFSVMADVLTFYSERYANEAYLRTATERFSVRQLAALVGYRPSPGVAASTYLAFNIDAAAGAYGAALVGPVPGQNVPLDSQTPGIPPGTGVQSIPSTPQELPQSFETTVPSVANPQWNAITPQLTQPQTIQGDTPAIVTSLQLTGTITSLKPGDSILLLHDNAPANFTKIRTVLRVSPATDGKTTLVELDGAVSGTSGYNPRSAPTLQGAINGSIDGISAIDLTDAAVAAVLQNTWDQGTLAALAQIRKWPLGQLEAAINQQVAQRAGSSGGKAYVLRQQAAPFGFNIPIQTYPNTSPAIPSNDPVNGAGIGSTNVIYLDAPYPGIAADSFAVVMDSTDRLCVSVASAPVTTVNQFKISGKVSALQLNATADFSKYPVRSTTILCQSEELPLAPVPITDGVASGTTQIVLSRAFLGLQAGQEVAIFGSRTDLPGVSACEVRRLQAVVLNSGYTVITLDSGLTYAYTRGSLSINANLAYATHGASVAETLGSGDATTPFQSFGLKQSPLTYVPAANAAGISSTLQVWVDNERWSEADTFYAHGPQEHIYVTAQDDAGNTTVTFGDGISGARLPTGTANLRAQYRYGIGVAGMVNTNQIVLLTSRPLGVRSAFNPVPAVGGVDPEGLDDARDNATLTIKALERVVSIDDFQSFARAYTGIHKASATWIWNGRRTLVLLTVAGVDGVVIDPGGTVGASLRQAITDSSIPGTPFVLQSYTPALFRLGGTITVQPDADTITVAASVETALRARFSFDARDFGQPVHLSEVIAAIQDIRGVRDVEITALYRSDQPVSLKKHLQASAAQPGFKKIVPSELLTLDPVPLFPALEVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L4</accession>
    <name>E8X5L4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3638</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581952.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70641">
        <property type="protein sequence ID" value="ADW70641"/>
        <property type="gene ID" value="AciX9_3638"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3638"/>
    <dbReference type="eggNOG" id="ENOG5030IQ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086678_0_0_0"/>
    <dbReference type="OMA" id="FTIHRIQ"/>
    <dbReference type="OrthoDB" id="1654743at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="29848" checksum="255A2A368C8B8291" modified="2011-04-05" version="1">MMTWTGRLVGLGLIACGVAGGLARAQDAKELLATLAQNEQTAGEHRGHYTYVAEERSDRTGGRLWTEKVVETSVGRVRFLLKEDGQPLNQEREAQERGRLAQDVANPDAFAKREAAQANDEAHAKQMLGLLQKAYLFDPPAVDAEFIRIQFRPNPDYKPASMEERVLHGMTGLVVIDRRMTRLRELDGRLASDVGLGFGPLAVVKAGSNFVTLREHVEGPDWKTESVHTDIAGRAFMLKSLARKIDAKRWGYQKVKDGLSVAEGVALVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P6</accession>
    <name>E8X5P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3672"/>
    <dbReference type="EnsemblBacteria" id="ADW70673">
        <property type="protein sequence ID" value="ADW70673"/>
        <property type="gene ID" value="AciX9_3672"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3672"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082427_0_0_0"/>
    <dbReference type="OMA" id="IATRAVC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26730" checksum="E076D4879876C0FD" modified="2011-04-05" version="1">MPKNVKQELSTVVPGANHRERILKAAMVLLAKGGRDALTTRAVAEAARVQPPILYRLFKDKAGLLNAVGEHGFGVYMAKKRSPVDTEDPVEALRAGWRLHVQFGLTHPELYLLMYADPHPGAESLAAERSHRILLEHMHRVAVVGRLRVSEERAARLFHAAACGMVMTLLEMKSDLRDMTLSDAACDAALAAIVVDAPMLQAPAIASVATTLRALVVSVDEPQRTKVFTKAEHALLIEWLDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P9</accession>
    <name>E8X5P9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SurA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3675"/>
    <dbReference type="EnsemblBacteria" id="ADW70676">
        <property type="protein sequence ID" value="ADW70676"/>
        <property type="gene ID" value="AciX9_3675"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3675"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_5_3_0"/>
    <dbReference type="OMA" id="MKAPYTE"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="42013" checksum="759AA4E4F0AF6D44" modified="2011-04-05" version="1">MKILDNKASEAYEVPQNRIQMQVQAQIHSQTRQRGTLFLLIPLLALAGCHPQHSADVMATVNGHAIMRADLDKVYNLQLGEAQQSQPSAEQADSQRLGLLKQLIDEEIVQQRATKMNLTATNEEVDAKLAEMKAPYTEEQFDGLLRERHTSVDDIKRDLRRSLTMNKLLNKEINSKVTVSDADITSYFNQHKSEFNNIETQYHIARILVTSSPAPQAGNLQGSKAQTDADAKKKILALKNRVDSGEDFGSLAMNFSEDPQTSASGGDMGSVAETQMKSNPIIFNSLANLKPGQVTDIMPFPDPSDPKKVGGYAIFQLLSRDPAGQHDVSEPQVQQRIRQGLHDARSQLLKGAYYEMLRDHAKVENFYAEQIFKSDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T8</accession>
    <name>E8X5T8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572734.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70822">
        <property type="protein sequence ID" value="ADW70822"/>
        <property type="gene ID" value="AciX9_4026"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4026"/>
    <dbReference type="HOGENOM" id="CLU_050006_2_1_0"/>
    <dbReference type="OMA" id="YIRIFSF"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233718" evidence="1">
        <location>
            <begin position="29"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="35358" checksum="3A036816E39AE630" modified="2011-04-05" version="1">MTSLTRRNFLAGTAAAAATLASPLRAFAAGSSFKIGVISDEISQDFDHACYVIAKDLGLHYVELREIWGKNLQVVSDAQIAEAQKILAKYSLQVTDISSPLYKVNWPGAPVSQYGSKEDLHGAAETTFKQQDEVLERSISLAKQFKTNKVRCFDFWRIDDVKPYRKAIDAKLQESAEKCAQQNIMLVLENEFACNTATGRESGTTLAGVSAKNFALNWDPGNAVMRGELDAFPNGWNAIPKERIHHCHVKNAVKDATGKIVWSPVDIGYVDWAAQFRAMKKIGYSDAVNLETHWKGGGTPEASTRTSWAGMKKNLQQADAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W0</accession>
    <name>E8X5W0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70844">
        <property type="protein sequence ID" value="ADW70844"/>
        <property type="gene ID" value="AciX9_4052"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4052"/>
    <dbReference type="HOGENOM" id="CLU_027402_34_1_0"/>
    <dbReference type="OMA" id="YYKWKSQ"/>
    <dbReference type="OrthoDB" id="1839196at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10406" checksum="FD9D03964AC4BC4D" modified="2011-04-05" version="1">MGRGKKYQPEQVVNLLRQIEVAVANGKTTALACKEAGIVEQTDFRWRKEYGGLQVDQAKRLKGLEQENSKLKRLVANLSLDNLALKNFASGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y3</accession>
    <name>E8X5Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cinnamoyl-CoA reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4084</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572779.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70867">
        <property type="protein sequence ID" value="ADW70867"/>
        <property type="gene ID" value="AciX9_4084"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4084"/>
    <dbReference type="HOGENOM" id="CLU_2569060_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="8519" checksum="25ACEE61E0EB431B" modified="2011-04-05" version="1">MQSSDPIFARTYVAIADYTGSYQFNSRLDGQSDAVAIPLEPFTLSATHPVTKVVSPTVNGTLSASTPSAVQPVVFSNTGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z9</accession>
    <name>E8X5Z9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572795.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70883">
        <property type="protein sequence ID" value="ADW70883"/>
        <property type="gene ID" value="AciX9_4103"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4103"/>
    <dbReference type="HOGENOM" id="CLU_058817_0_0_0"/>
    <dbReference type="OMA" id="DHPHHVG"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029475">
        <property type="entry name" value="PmoA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14100">
        <property type="entry name" value="PmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234224" evidence="1">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="38659" checksum="6510E812748A01BD" modified="2011-04-05" version="1">MYSRRIFGIASVALLMSVSALKAQAGKGVQVTPNEADRRVDITIDGERFTSYVWPTSLKKPVLYPLIASDGVTVTRGYPLEPRPKERVDHPHHAGMWFNYGNVNGFDFWNNSDAIKEADREKMGSIHQDRIVSTKSGKDRGELTVESTWTTGKGTDILKETTRYVFIKRGDARIIDRVTTLKALDQAVFNDDKEGVLGIRVAHFLESPNEKGGIFMDAEGRPTKVDAVDTSGATGVYRTSEGVEGEKVWSTRGKWCTLTGTTDGKTLSIAILDHKGNPGYPTYWHARGYGLFAANPLGDHIFDPKAPEHKFTIAKGQSATFKYRVIIFSHSAITAEMNKESAAYDAEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X655</accession>
    <name>E8X655_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4159</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572851.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70939">
        <property type="protein sequence ID" value="ADW70939"/>
        <property type="gene ID" value="AciX9_4159"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4159"/>
    <dbReference type="HOGENOM" id="CLU_083287_7_0_0"/>
    <dbReference type="OMA" id="GWACTRA"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16182" checksum="5D774182F46BE1C6" modified="2011-04-05" version="1">MNKLLPNVARGLLTAARAHTTAVVARLAQRGYVDFPFASANVLWLLDEGGTRSTTLAQRAGVTKQAMSQQLKQMEREGYLEQVPDLTDTRAKVVRMTPRGESVKAACAEVRDELNQTVAKLVGKSKAREMEAHLDAATQAFADIAAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X673</accession>
    <name>E8X673_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4178</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572869.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70957">
        <property type="protein sequence ID" value="ADW70957"/>
        <property type="gene ID" value="AciX9_4178"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4178"/>
    <dbReference type="HOGENOM" id="CLU_009600_14_2_0"/>
    <dbReference type="OMA" id="SGWAFDD"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230271" evidence="2">
        <location>
            <begin position="26"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="59675" checksum="58BD17B96660D278" modified="2011-04-05" version="1">MIRLTSIRSLSAAALFLCTTPLLLATPPATKAQLDRDLLEATIPSLQSLYATHRYTVVQVTQWYLDRITQYDTRYKALIHVDTAAALATAASEDKAAAQAGKSFHPGPLWGIPMVIKSNTSIKGLITYDGWKDFQIPGKELVAPKDATVVTRLRAAGAILLAQTNMPDFAASDTNKSSAFGRTGNAYDARFSPGGSSGGTVTAVTANFALLGTGTDTANSIRMPSGTSAVVGILPTRGLVSIAGIAPLDWLRDNTGPIARDVTDAAIALGVMAGEDPQDFRTKASGTKAQPAPYTAYLKPDALKGKRLGVPAFIVAQSSTPTTSTMGQSRDSTLRPETRALFLKALDELRAAGATIVIADDLLPESFARMPVTTRPYLREGMDHFLRDYGPTQYHSIADFEKTTGSSIPGNIIGSNSPRQPAVTQRDLESDPEANATFFAPQQAMLAAYNEGLDRYHLDGYVYPALQMPPNDETIPQPDGRPSSGPHSNTGWVNKIGVPAIVVPSGFYASGLPTGIEFSTRPWHDGDLLGYAFAYEQFTHHREPPVLVTQPRPAEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X685</accession>
    <name>E8X685_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-galactosidase trimerisation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572881.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70969">
        <property type="protein sequence ID" value="ADW70969"/>
        <property type="gene ID" value="AciX9_4190"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4190"/>
    <dbReference type="HOGENOM" id="CLU_330357_0_0_0"/>
    <dbReference type="OMA" id="LYDEYPY"/>
    <dbReference type="OrthoDB" id="312576at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230272" evidence="1">
        <location>
            <begin position="19"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="737" mass="80978" checksum="037660B7E1C44146" modified="2011-04-05" version="1">MKTILAGMMMSLACCVSAQQPWQKIQMVSADEVKKGWVAPAAEYGPEPYYGLNGAVDASVYERDLDTMKRLGYGAVTVQAGYGMTQAYLSPEYMGFFREFVLAAKKRDMRVWIVDDAGYPSGFAGGKFTELHPELRMQGLAVAAKYPAQGGETVKQAVGAGTVSVTAIDTDGKTVPVPVTNAGIAWTAPAGSWTVMVVEHRFMTSPTRSDTNPKRVKDGSQSLEDYMDPAATAVYLAFTHEAYKKAIGDEFGKTVMGFRGDEPDYSIGGLPWTPKFFDHFMAVKGYDVRPYVASFLIPMAKETRDAKLTEVQKRARADYYDVISQMFRDGFFKPQGDWCAANHLEYQVHLNHEEMEMQLVKSEGEFFRDMKYVQVPGIDSIWHQIWTDTVSDFPRLASSASHVYGHPRAFTESFAAYRPEPDVTMARYILNEQFVRGVNLVETMYFPASTGGKGGPAKYMQDPAYPALLQYVRRMSYVMSMGRPDATVGLYLPSSSMWMGDASSDAMFVSTERLLSEHQIDFDIVSEDALGGELKVDGAAFVTASGNRLRTVVVPGASVLSEAVVARLKKFAAAGGHVLFLGRTPGLVFGRTLLDARAAKTDEFAWAKSVTDVQLPETPTPPAYPPTVAPTELLAAPTIVRALSAVTGFEEMKLAHEDSALRYTHRRLKDAEVYLFFNEGADAKTDTVMLQGSGGKKIEAWDAETGTVRAVVAKKMDGGVSVPLDLKGYETRILVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B3</accession>
    <name>E8X6B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASPIC/UnbV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4219</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572909.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70997">
        <property type="protein sequence ID" value="ADW70997"/>
        <property type="gene ID" value="AciX9_4219"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4219"/>
    <dbReference type="HOGENOM" id="CLU_017657_0_0_0"/>
    <dbReference type="OMA" id="GQGCCVG"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="3">
        <location>
            <begin position="526"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="622" mass="67247" checksum="596178C10E526095" modified="2011-04-05" version="1">MIWTRRGLIKSLSRTAVVLTLEDVLKLAWPAGAQEVAQQVGARPTYDTKPRPAPKGVASPVTGTPLGYSFVDVAKQSGLTTKTIYGGEHKNRYLLETTGCGVAFYDFDHDDWLDLFLVNGTRLEGFAKGQEPVSHLFKNNRDGTFTDITAKSGMTRSGWGQGCCVGDYDNDGLNDLFVTYYGQNILYKSHGDGTFTDVTTKAGLTQSKMRWNSGCAFVDYDKDGKLDLFVANYIDFDIKTAPLPEAAGCAYKGMQVACGPPGLEGGKNILYRNNGDGTFTDVSEKAGMWGTIGTYGLSVTVADLDNDGWPDIYVANDSTAATYYQNQKDGTFKDTAIEAGIAYSPDGKPQAGMGVAVGDFNRDGLLDIVKTNFAGDTDSLYQNLGDGTFEDHTYLSGLGVNTRYLGWGVGFVDLDNDGWLDIFISNGHVYPEVDGSHLDAPYAEHKYVYRNLRNGQFEEVTNLAGNGMTDAVAARGCAFGDFDNDGDMDVVVNCVNSLPQLLRCDSTVARNWIKIRVVGKKSNRAGIGTRITVIAATAAQDKSGMGKQPLRQIDEVRSGGSYYSQNDLRIHFGLDGAKTADVELAWPSGAKDTLTGLAANKLYVIEEGGKVLKTMAMDGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E3</accession>
    <name>E8X6E3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M1 membrane alanine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4251</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572939.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71027">
        <property type="protein sequence ID" value="ADW71027"/>
        <property type="gene ID" value="AciX9_4251"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4251"/>
    <dbReference type="HOGENOM" id="CLU_014298_1_1_0"/>
    <dbReference type="OMA" id="TIGKFDV"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234238" evidence="1">
        <location>
            <begin position="25"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="3">
        <location>
            <begin position="60"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="279"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="63809" checksum="A7CF5AC5EBEEC493" modified="2011-04-05" version="1">MARASKFLHLAALLLPLGSLVSVAAQTAHPANIPMAETFTEADRLRGSYGPYRSNNDLLYYHLDVRVDPAKKSISGKNSVRFKMLEDGQRIQLDLVSTLQIDKVLFDKPKGATTPLHFERAAGRTVYIDFPRTLPKGETDTIEVFYSGHPVEMGRFGGIVFRKDPMGRPLVNTACEEEGASVWWPNKDQWRDEVESMDLSVEAPSDLVEVSGGKFQGKTDLHDGFTRWDWKIQYPINNYDVSLNIGTYVHFSDTYKTLPLDYFVFPEDIEKAKHQFVQAKHMLKAYEHYFGEYPFLKDGYKLVEALYSGVENQTAITYGNHFENGYLGRPRTGIGTRFDFIIIHESAHEYFGNSITAKDRSDMWIHEGWANYCEGLFVEFMWGKSDGITYVNTGKENVKNQFPVISQEGVFSTPPGDQYKKGGLFLNTLRSVVGDDVWFPLLHDYYQHFKYQTIMTTDMVAFFNQQTKMDLTPIFNQYLRHAAIPVLQLRFDDAAHTVSYRWQADEAAFAMPIRVGSKENWQLIYPTTSEWKTLSTPLTKDQFEVATDMYYVGISKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S6</accession>
    <name>E8X6S6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3950</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582244.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71226">
        <property type="protein sequence ID" value="ADW71226"/>
        <property type="gene ID" value="AciX9_3950"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3950"/>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_0"/>
    <dbReference type="OMA" id="WSAMGEQ"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26425" checksum="FDB2774E630B4595" modified="2011-04-05" version="1">MTVHFIGAGPGAPDLLTLRGRDLIAASPVCLYAGSLVPKEILTHCPSNAHIVDTADLTLDQIIAEIAAAHAANLDVARIHSGDLSIWSTLAEQTRRLRALNIPFDVTPGVPSFAAGAAALSQELTLPHVAQTIILTRTSTRSTPMPPGEDLATLGRSGATLAIHLSIQNMDQVTGQLLPLYGPDCPAVVVFRASWPDEQILRGTLATIQQQVQDSGIDRNALILIGKSLGQPGFGESYLYSTTRDRTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y9</accession>
    <name>E8X6Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3812</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582120.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71098">
        <property type="protein sequence ID" value="ADW71098"/>
        <property type="gene ID" value="AciX9_3812"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3812"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NKFHGTA"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233758" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1098" mass="117791" checksum="9A3AC9E5D47562E8" modified="2011-04-05" version="1">MKNAFVCLPLIALSSFAMKAQVANNTSLVGTVTDAAGALVTGAKVVGVNRDTKVAYPAVTNGEGYYSIPYVLPGTYDITVEHAGFSKVLSSGVTVVLNVAARTDVVLAVGSDTSEVTVSAATAVLSTDDALLGETLGTKQVENLPQNTRRVMELAATASNIIIGPKTSYNGNPPGANFIGAGTREVTNSLTLDGITIMNSLISNSSVTPNPDAVGAVQTQTGNYTAQYGAYMGVHINVDTKSGTNKFHGTAYDYVQNNFFNAKGWLTPSNQPTPIQRFNQFGGEVGGPIRIPHLFDGRDKLFFMGSYEGLRSQVQNSTPGTVITDAERTGDFSDLCSAFTAGLCTTGKQIYNPVNATPYLNNKITNISPIATALLTYFPHPNLAGTVNNINLPVGNVFNKNATLDRVDYDVNEKVRLFARYTYEKSNAINGALVTTSSSYSPTTDTNAVIGYTHIITPRLINDFRFGFNKFSSNQLNYFYVNGPAGAGTALGIPGFNSDTTITNNAGIPTIAISDGYNGLGAEGTNWFQDDRTLHGYDQISYTFGKHNLMAGADIRKMGLGRAAQNQPRGQFTFNDTYTGNAVADFLTGYSSQAITPLTTVKGSVAEWRDGFFVQDNWQATQKLTLLYGVRYELPTVPYSLNGFARILNTTYTALIPTSSATNAATFTPTPGFKFTGPNHDLVSPRLGVAYRATDRIVVRGGGGIYYNPNHLNAFTLASGNYPIAASVSYNGNVRVPPALTALGNVSFANPSGGASATASPVAGTPGTYVNQFTDNFYLPTPRLYQWNLDTGVELWKNGAFEMQYLGSHSIHLDHSQYVNTPTPAAGAVNPRRPYQLFGDIRQIQNDGLGTYHGLTVIYRQRAFHGLDANLSYTWSHTLDTSNDANGGGTPMIQYNLRADYGNANWDIPNRFVGTVTYAMPPLTQFGHLTDTLVGGWQANAIVTIQSGMPFNVSIAENQANVGSIGTQRPNYVHAPSAKNCTRYTRINGAVNSSKSCIDLTAYSLPTQYTFGNTHRNDLHGPGQINVNFSMFKNFAIVEGLKLQFRGEAFNLFNHVDPGNPNSGLPSFSGGTNTFGTITSIATGTSSRVLQLAGKIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X701</accession>
    <name>E8X701_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3824</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71110">
        <property type="protein sequence ID" value="ADW71110"/>
        <property type="gene ID" value="AciX9_3824"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3824"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_0"/>
    <dbReference type="OMA" id="VYYFSMW"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="32"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="46791" checksum="43A3095B80BE795E" modified="2011-04-05" version="1">MVVSRVCGTEQNPLAGSEAGMKALYRRVTLRVIPLLIVLYFTAFLDRVNVSFASITMNRDLGIGESAFGLAAGVFFIGYLVFSLPSNLMLERFGARRWIGIIMVALGLLSCATAFIHTASTYIVLRFMIGAAEAGFFPGVILYLTLWLPASVRASLMALFTLSIPLSNVIGAPLSAAILSLNGRGGLQGWQWLFLMEGCPAIVLGCAVPFLLAARPQEVSWLTTDESRALGDAIAREETLAPSGDGVTFSFGQWFALFRSGLIYFFLMVGLYELSFWIPRILHDRGVPAAELGWKTAIPFAVGGLGMVLWSRFSDRSGRGQMQLAFAFIVGASGLVLAGVGTGWLPAVAGLSITSIGVLAGMPIFWAWVTAGMGAERAFAIAGINSIGNIGGFLGPYLTGMILEHTHSFRPGMWLTAACLLCGAGLTSVTSKRPGHLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X718</accession>
    <name>E8X718_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3841</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582149.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71127">
        <property type="protein sequence ID" value="ADW71127"/>
        <property type="gene ID" value="AciX9_3841"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3841"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="26022" checksum="96219D79684ABE38" modified="2011-04-05" version="1">MFDLNGRRAVVTGAASGIGLAVAQTLARAGAELVLLDLDAGKVAETAATLPGAVAIQCDVASEESVTEAFRLAGLPIDLLVNCAGIAHVGSLETTSVADLERLYRVNVQGTYLCMRESVKGMLAGQGGAIVNMASIAATSGLSDRFAYSMTKGAVLAMTLSVAKDYLARGIRCNCISPARIHTPFVDGFLAKNYPGAEAEKMTELAAAQPIGRMGRPEEVAALVVYLLSDEASFVTGVDYPLDGGFFNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X736</accession>
    <name>E8X736_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4311</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572989.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71270">
        <property type="protein sequence ID" value="ADW71270"/>
        <property type="gene ID" value="AciX9_4311"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4311"/>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_0"/>
    <dbReference type="OMA" id="APIIYEY"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="22611" checksum="8A3E258A1653FCAE" modified="2011-04-05" version="1">MEAKRAPNRIAERKLRDKQARRAQIISAARRIAELEGWPNVTVRRLSDEISYSQPVLYAHFGSREGVVSAVATEGFQELGLAMEKARKRAKRGSTVEAAAIAYLEFAASMPALYEAMFTLSLSVPFGDAATPSELRFAFSQFIELFQRRSSKPEIVSELFWGSLHGIAELTRTKRFPPGRQKERVKALVGLFNFPGEETADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G6</accession>
    <name>E8X7G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573119.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71400">
        <property type="protein sequence ID" value="ADW71400"/>
        <property type="gene ID" value="AciX9_4454"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4454"/>
    <dbReference type="HOGENOM" id="CLU_174532_0_0_0"/>
    <dbReference type="OrthoDB" id="1981428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="9782" checksum="961E4EED8B3125F6" modified="2011-04-05" version="1">MPLLEIVASKKITATVTLEESTAKQVDQYAAMTKASADDVIDSALAYVFGKDTEFKKWCTDNPTFKASFPLRLKRPAPSTGTKPSTSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N2</accession>
    <name>E8X7N2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4525</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4525"/>
    <dbReference type="EnsemblBacteria" id="ADW71466">
        <property type="protein sequence ID" value="ADW71466"/>
        <property type="gene ID" value="AciX9_4525"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4525"/>
    <dbReference type="HOGENOM" id="CLU_965640_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="32165" checksum="C7C3C864C74D3ABD" modified="2011-04-05" version="1">MVDVTSHTRDELTSKGTVGERASEVELQDAFDEFFGIRSDDDPPGVIILQSDLLDAKHTQSDSRFFKARNVIDSCDLQGAFFLQKAFKWRPVPRLVVSDHNTQNGLDETVPFKIAMGLGFTDETSRVMESRDYGSWMSISREGGDALSLHEKLKPSLNKSRFRTETDPDPEKPGFVRVLPSDWDAKYIKAWERMLPPKNGPRVSDYAVLLRHTYNRQILFVVAGFTERGTSIGAAHLAANWSKLWEQYVQGNAYKRGLGDFLVLIAGPSDVNCLGSLCAGGRFDDVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R3</accession>
    <name>E8X7R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide biosynthesis protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573216.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4566"/>
    <dbReference type="EnsemblBacteria" id="ADW71497">
        <property type="protein sequence ID" value="ADW71497"/>
        <property type="gene ID" value="AciX9_4566"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4566"/>
    <dbReference type="eggNOG" id="COG3754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038570_0_0_0"/>
    <dbReference type="OMA" id="GHYQPRE"/>
    <dbReference type="OrthoDB" id="1006904at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="CDD" id="cd11579">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032719">
        <property type="entry name" value="WbsX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41244">
        <property type="entry name" value="PTHR41244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14307">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="44619" checksum="EA0EE939DC40FC6B" modified="2011-04-05" version="1">MKSPAARVIAFYLPQFHPIPENDEWWGPGFTEWTNVAKAKPMFRGHKQPRLPADLGFYDLRVPESREKQAELARNAGVESFCYWHYWWGHGKRILERPFEEVRDSGRPDFPFCLAWANQSWTGIWHGNPRSILMKQEYPGRADEELHFRWAQKAFEDPRYTCVDGKPMFVIFAPHDMPSTEAFCEHWRELAHKAGYPGLHLVAISNKYADGIDRYRNPILRPFDAVTQLVPQDYLETIGRTTKRRDLVRKWKELDFGGRLNHLKPTSWRRPTRIRYKDVVARALEDMPQEERFLPCVLPGWDNTPRSSHRGVIFEGETPELFRTLLQKAVQHVSVNSVEQRIVFLKAWNEWAEGNYVEPDVLHGHAYLDVIRSVVFPGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S3</accession>
    <name>E8X7S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4577</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4577"/>
    <dbReference type="EnsemblBacteria" id="ADW71507">
        <property type="protein sequence ID" value="ADW71507"/>
        <property type="gene ID" value="AciX9_4577"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4577"/>
    <dbReference type="HOGENOM" id="CLU_635795_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="431" mass="47443" checksum="BB6589F1B2621B19" modified="2011-04-05" version="1">MTCLRLYRTHLALLVTLSICAAASLGDLWLIKGYLSPTQQYDFEVYFTASSEIAQHLDAHLYDESGNGLNPQLRDADPSGTMAHVARQQGIQQIKLYLYPPLLADLLQPVARLKLPDALLLWRSLNIGFLILASLSIAALLRKTWWTLPSLIVFSGLLCFSPIWQALHYGQITLLLLFLWATGILAYAKGWTKTSAVLLGIASLLKLTPLLAVVPLLIWRDWRWLRSFGLTLAIGLGAMVFINSPHVVMFYAQHVVPPMSSGIGDRQNQTVLSVLQVISSGRHPHLGKLAPTSIAWTGHILSGLLVAIAVFLTVLRQKNLSTSSKPIILAAFALLSLCVSPVSWVDAFAIGYILIALQWNHSFVQKTSIVQLLLLTASTAALGGSLAIKHIHKLDSFLFAQYLPLFFAIYLVFFTLLPSSISPTEHPHPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V5</accession>
    <name>E8X7V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71539">
        <property type="protein sequence ID" value="ADW71539"/>
        <property type="gene ID" value="AciX9_4609"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4609"/>
    <dbReference type="HOGENOM" id="CLU_035706_6_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="2">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="27990" checksum="E1E6AA2467E93E2B" modified="2011-04-05" version="1">MRQGRRHGLSAEEKVGIWRRWKAGESLHEIGRAFDKDHGSIQFLLAKHGGIAPAVQRRSQRTLTLAEREEISRGIASGSSIREIARGLERAASTVSREVARHGGRPMYRASEADDRAWKSALRPKVCLLARHRKLRLIVASKLILNWSPEQIAGWLKRRYPSNESMRVSHETIYRSLFIQARGVLKKELMQHLRSRRQIRRSVHAKAAGQSRGRIVDAISISERPAEIEDRVTTSRSPSASTISRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z0</accession>
    <name>E8X7Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4644</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573293.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71574">
        <property type="protein sequence ID" value="ADW71574"/>
        <property type="gene ID" value="AciX9_4644"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4644"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OMA" id="PATTNKM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="127"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="34975" checksum="D267059648AF142E" modified="2011-04-05" version="1">MSQETAISVLNTAEQASNSSQARLIALVLDGVTSEHSRRSYRTGLTAFFGWIRVGVDVSGTEPAFTKALVQLYRSSLLVQGLSSSTVNLRLSPLRKLAREMADNGMLDPATAAAIERVPGVEKRGNRVGNWLMKEQANDLLNAPNSKTLTGLRDRAILALLLGCGLCRAELLRINVEDLQQREGRWVLPDMEGKGSRVRTVTVPAGVKTRIDAWLKASGITDARLFRPVSKAGELAGTEIRDEKAVWRLVMRYAKATDLGKLAPHDLRRTCAKLCRKAGGDLEQIQLLLGHASIQTTERYLGTEQALAHAVNDAIELDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X832</accession>
    <name>E8X832_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4687</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71616">
        <property type="protein sequence ID" value="ADW71616"/>
        <property type="gene ID" value="AciX9_4687"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4687"/>
    <dbReference type="HOGENOM" id="CLU_2665964_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8592" checksum="A230BF6E70EC5DE7" modified="2011-04-05" version="1">MKLSVSHPSPQSLEIDTVRRFPHYAPHDDWYGLLDKYINKLTYTDTSNGLATLSFLMSYNTLCSGSLEMVLAHIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG3</accession>
    <name>E8WVG3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1351</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579734.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1351"/>
    <dbReference type="EnsemblBacteria" id="ADW68411">
        <property type="protein sequence ID" value="ADW68411"/>
        <property type="gene ID" value="AciX9_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1351"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_0"/>
    <dbReference type="OMA" id="RFERWRP"/>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="357" mass="38726" checksum="0729CDCDBB3BB4D4" modified="2011-04-05" version="1">MAEIGVGVIGFGLATKVFHAPFVSAVPGLKLKAIVQRSGDEAAQAYPEVKIVRSVEELLADPAIALVVVATPNETHFPLAKQALEAGKHVVIDKPFAATSEQARELIELAQEMGLVLAPFHNRRWDADFLTVKKVMADGSLGRLVTFESHYDRYRPTLRENTWKEAANPANGLLMDLGPHLVDQVLSVFGQPETITASVRTDRDAKGIEDAFDIALGYKGLIAWCRSSMLACDASPRFLLHGTAGSFKKYGLDPQEPALLKGAKVPRMGSDEVWLQEDASAWGTLTVAPDLNKPAELVKTTVKSEIGDYRNFYASVRDAISGAGELEVPAEAGYDCVRVLELARVSSQEGRSVRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ3</accession>
    <name>E8WVQ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2553</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2553"/>
    <dbReference type="EnsemblBacteria" id="ADW69582">
        <property type="protein sequence ID" value="ADW69582"/>
        <property type="gene ID" value="AciX9_2553"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2553"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668626_0_0_0"/>
    <dbReference type="OMA" id="AHHNPME"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="46316" checksum="24547C5437046981" modified="2011-04-05" version="1">MPTYLAKRSSDEIGVRFRVCDGDGRVMPLCDEFLFQLRLRDCSVYTQRAYALGLAHFFTWLGANGVEPERVTRQVIGRYIADFGESEPGGAVTTRAAPKARSARTVNHRLSVLASFFDFHIRRDTEDGAGPWCGRTNPASGKLLDRELRHGMMGRDLPPRTRQRDGFRRRVPYEVPKRIEPEEVQRLIDAASSFRDKANLTLLCRTGQRIGDWNESAGRHGILGMSLSDVDRKRGLIVVRLKGARDEHRVPVTDDFWPVYERYLKEERRTAEDCEALWIALRKGRGKPLTYAAFESSLRYIGGKAGVPVHPHLFRHTLAQGVLDLTGNLKIAQEILGHAHISTTADIYTRVDPVSLVTALAAAKSSFDAAHRPSLNVPSEERRYVFDYDADTIAELEDAVNNQALTRRPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA5</accession>
    <name>E8WWA5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1430</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579810.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1430"/>
    <dbReference type="EnsemblBacteria" id="ADW68488">
        <property type="protein sequence ID" value="ADW68488"/>
        <property type="gene ID" value="AciX9_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1430"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_0"/>
    <dbReference type="OMA" id="FARNEHK"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="13"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="36029" checksum="DB7642477DAC024B" modified="2011-04-05" version="1">MNAIHGLAVHAAGAHLLPYKYDAGELKEDEVEVKISHCGVCYSDVHLIDNDWSISKYPFIPGHEIVGTITQIGSAVDDRVLGERVGIGWQANSCSVCEWCRQGDEHLCAKSQPTCVGRNGGYADSIRVNWRFALRVPEVLESENVAPLLCGGITVYSPLRNLGVRPSSRVGIIGIGGLGHMGIQFAKAFGAEVTAFSTSKDKEAEALELGAHHFVNTRDTGAIKKVAGSFDLLLSTVNADQDWQGYVNALRPKGSFVFLGAPPTPVPLQVSALIFGQKCVAGSPTGSPHDIEEMLDVAARHGIKAITERFEMAKANEAVAKVKKNQVRYRAVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA7</accession>
    <name>E8WWA7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage transcriptional regulator, AlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1433</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68490">
        <property type="protein sequence ID" value="ADW68490"/>
        <property type="gene ID" value="AciX9_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1433"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034784_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010260">
        <property type="entry name" value="AlpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05930">
        <property type="entry name" value="Phage_AlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13441" checksum="4E61381E210A66F2" modified="2011-04-05" version="1">MNRSNLNLREANEVLSVDSQTKSANGKPLQRDSEEVIFLRLPKVKAITGLSKSSLYELIRANSFPAHVHLGARTVAWVASDVQQWATERIVHSRPPASIVDGRRVPQRALPGQWASSKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN7</accession>
    <name>E8WWN7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="13" type="ordered locus">AciX9_3782</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582090.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3782"/>
    <dbReference type="EnsemblBacteria" id="ADW70782">
        <property type="protein sequence ID" value="ADW70782"/>
        <property type="gene ID" value="AciX9_3782"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3782"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_0"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="317"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="687" mass="77482" checksum="9C849D09CD1989A3" modified="2011-04-05" version="1">MTEQIAVSTIRVQLPDGSIREVPSGTTPLEIATSISPRLAAVVVVAKVKPMAGLDINQSEGGQDDAPDAGSEEAMYDAALSPSAERIIDLAMPLAEDVELWLLKEQDEESLKVLRHSTAHVMATAILELFPETKLGHGPATDAGFFYDVYRETPFTEDDLAAIEKRMGEVVARNDAFVKETEPREDALQEYAAEGEFMKVHFIERFTQAGEPVSLYRNGGFTDFCRGPHVPSTGRVKAFKVTSVAGAYWLGDEKNQQLQRIYGTAFFNAKDMDAHFKRLEEIKARDHRVLGKQLDLFSIQEVAGAGLIFWHPKGGLIRKAMEDWMREDCIKRGYEMVFTPHIMRRELWKISGHEENYGENMYPPMELDDAEYRLKPMNCPGHILIYKNSPKSYRDLPVRYAELGNVYRYERSGTMHGLLRVRGFTQDDAHIFCTPGQIEDEVTACIEFAESVLNTFGFHEFKVELSTWDPNDKKFIGSAEQWGVAVGSLRNALERKGIPYKTIPGEAAFYGPKIDIKLVDVLGRMWQLSTVQFDWNLPARFDLHYKGEDGELHQPVMVHRALFGSVERFFGVLIEHYAGAFPFWLAPVQVGLVPISEKHLEYARTVQQRLKDAGVRVELDERNEKMNAKIREFGVNKVPFILIMGDKESQSDEVSVRTRGKGDGGAMSTEAFVARCLELQKSHSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR0</accession>
    <name>E8WWR0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0316</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578716.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0316"/>
    <dbReference type="EnsemblBacteria" id="ADW67388">
        <property type="protein sequence ID" value="ADW67388"/>
        <property type="gene ID" value="AciX9_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0316"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_0_0"/>
    <dbReference type="OMA" id="DGHSRLM"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="500" mass="52209" checksum="DDAE888186FF55D4" modified="2011-04-05" version="1">MSVSPLDAPKSEHEQAALPAPDAQKALPAPHDGGSQKNAGGIWRRVVLVLVLLACCAFGYWRIRGNKADAAKEEQKTAAAANRATPVTVAPVAAKTMPIYFTALGTVTAYNSVTIKSRVDGQLLSVNVREGQQVKQGQVLAMIDPRPYAAAVAQAEGQLAKDEAAARNNEAEANRYRSLYEAGVVSKETEQAQISNSGQSVGTLDADRAAIQAAKVNVAYTRITSPINGVVGLRQVDPGNIVHAADSTGLILVTQLQPISVIFTLPEDQLPEVLKLMRAGKKLVVDAYDRNQSTHLATGSLLTIDNQIDTTTGTVKGKAVFDNKDGALFPNQFVNVRLVLEERENSLVIPAAALQTGAGGNFVYVVKEGNPPHQADDKKKKTDGDGAAAPEEEAAPASGKPAGPKYYVQVQNVVVDLTEGSQIILKSGVNAGDSVVIDGQEKLKPYGKVAPKQGQSSAGSSAGKRMGSAGAARSKASSDTTTSQAPQPTAVPAGQAGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX48</accession>
    <name>E8WX48_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron donor protein CyaY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2666</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581005.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2666"/>
    <dbReference type="EnsemblBacteria" id="ADW69690">
        <property type="protein sequence ID" value="ADW69690"/>
        <property type="gene ID" value="AciX9_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2666"/>
    <dbReference type="eggNOG" id="COG1965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2154805_0_0_0"/>
    <dbReference type="OMA" id="VRQIWIS"/>
    <dbReference type="OrthoDB" id="1812841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="SSF55387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12454" checksum="1DD0E987C0CA1D2D" modified="2011-04-05" version="1">MIDEPTFRRASDKALESLKQSLIRVEEEGGFEAEDHNGVLNVLFEDGGTKFVFTPQTPVRQIWISARTTSFKLDWSEDAAAFVLSKTGETLLLLTQRLLQEQLSDPSILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX69</accession>
    <name>E8WX69_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2687</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2687"/>
    <dbReference type="EnsemblBacteria" id="ADW69711">
        <property type="protein sequence ID" value="ADW69711"/>
        <property type="gene ID" value="AciX9_2687"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2687"/>
    <dbReference type="HOGENOM" id="CLU_2537836_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="9249" checksum="D684DB9E628DAB1F" modified="2011-04-05" version="1">MTEGEANNTLKVLLEAFTRTNEIAFLTLQTLHKTVPGFSEEYSKAESVWNSREKLSETESQNTIGGSSTEIVDLVSRLLSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX97</accession>
    <name>E8WX97_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2715</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581054.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2715"/>
    <dbReference type="EnsemblBacteria" id="ADW69739">
        <property type="protein sequence ID" value="ADW69739"/>
        <property type="gene ID" value="AciX9_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2715"/>
    <dbReference type="eggNOG" id="ENOG502ZPI4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568542_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="170" mass="19542" checksum="B05CCF83A0F20607" modified="2011-04-05" version="1">MLASTSNLSYWFPLITAGVALLTALLTVVSSQTLEWLKERRSYRREVETRLLTRREALRERRNDFQRQTLLDLQDAILEYVSVKLETQRLQPSNELASKVLLANARITKLMTRVEDEEVRRLIDRAQEATRVTRPGESPAAAERPLGLILEEINNRIGGLLRKLDSEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH9</accession>
    <name>E8WXH9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578840.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0440"/>
    <dbReference type="EnsemblBacteria" id="ADW67512">
        <property type="protein sequence ID" value="ADW67512"/>
        <property type="gene ID" value="AciX9_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0440"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078235_1_0_0"/>
    <dbReference type="OMA" id="WKWAFRY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="26769" checksum="0A79F94A27CA062F" modified="2011-04-05" version="1">MDQPCSFEELRGCLRDISQVNRLTFAYRPTLHWLDYVYSVMPRQEKPLHIVDVGCGYGDMLRRIYEWAEWRRVPVVLTGIDLNKDAIRAAREVTHPGRVTYLAGDAYSFEPAGGIDIVVSSLMTHHMEDAEIVEFIRWMDAKTRIGWFINDLHRQAVPYRLFRALTWFTTWHRFVKHDGPVSILRSFRREDWLELIEAAKVPEKTYAVKEYKPARLCVARMKELGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM9</accession>
    <name>E8WXM9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Squalene-hopene cyclase</fullName>
            <ecNumber evidence="5">5.4.99.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1592</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579964.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1592"/>
    <dbReference type="EnsemblBacteria" id="ADW68645">
        <property type="protein sequence ID" value="ADW68645"/>
        <property type="gene ID" value="AciX9_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1592"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019345_0_0_0"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="260889at2"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051007">
        <property type="term" value="F:squalene-hopene cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="3">
        <location>
            <begin position="339"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="673" mass="75992" checksum="4B590979712DD6F1" modified="2011-04-05" version="1">MSAATPINPEATKQPRFGRIDLGLEVIANGIKRSAEWLLGLQHPDGYWCGELEADSMLESDYIFVHTLLGTGDPGRLSRALNEILRHQNDDGGWSLYPGGPSNVNYGVKAYLALKLMGYTADHPVMVKARECVLRLGGVVECNTFTKIYLCGLGQYDYDAVPAVPPEIVLFPDWFYFNIYEISAWSRAILVPLSIIYAKKPFKKLTPEQGIDELFVGGRAGANLRLRWDKKHPLSWRNVFLFLDRVAHLAERVHIRPLRSIALKKAERWMLDHFERSDGLGAIYPAMLNAIVALRCLGYSADDPQVIRAMDEFERLGIDCPEGTPDYPTPTFRMQPCFSPVWDTAQVLSTLGDCGLPRNDERLVKAADWLLSKEIRYKGDWSHTVKNVDASCWCFFFNNDHQPDVDDTGEVLLALKAVDNPRERYQHETAQRAIEWVFAMQCKNGGWASFDKDNTKKIFESIPFADHNAMIDPPSVDITGRILEMLAGYGYTRRDPRIEKAVQFILREQEPDGCWFGRWGVNYLYGTFLVLRGLQSMEYDPYEPAVQQAAEWIRMVQNSDGGWGETCGTYDNPSLKGTGPSTPSQTAWALLGLLAANDTRSDSVAKGVRWLIDRQHEDGSWDELAAGRNGESHYTGTGFPTVFYLGYHLYKQYFPLLALTTYKQAMERESAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS0</accession>
    <name>E8WXS0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2741</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581080.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2741"/>
    <dbReference type="EnsemblBacteria" id="ADW69765">
        <property type="protein sequence ID" value="ADW69765"/>
        <property type="gene ID" value="AciX9_2741"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2741"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_0"/>
    <dbReference type="OMA" id="RACQEVT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="440"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="574"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="797" mass="87990" checksum="511B16171B77031B" modified="2011-04-05" version="1">MKTLSRDEALRLEALEEYEVIGTAPDSGIDDLTQLAAQICGTSMAGISLVGADAVYFQSRFGPGPPRLPRGSVPCETAILGDSVYEIPDARYHRDYRPDGIMVAGRVTRFYAGAPLAGGAGINIGCLFVQDSAPRTLSETQKSALQVLARQVTTRFELNARVRHMDRAGRSRLRVESALSVERNFVSAMLDTVGALVLVRDTAGRIVRFNRTCEAVSGYDLQSMVGRYVWEKLIPENEVAESVSTFERIVNGSSPTSFENHWLRRDGSLRRIAWSATALVDPQGQTNFIISTGIDVTEQREAEDTLRESEARYRQLIEGSLGMVCTHDLEGKLLSVNLHGAQSVGYEVEELIGRNLALLLAPSRRPHFQDYLRQVQQTGEAQGRLYLTHRNGSERIIAYRNKLIEIAGREPYVLGFGVDISEQVQAEGKLRNLIDQSNSILESVGDGIYGLDLEGRVTVVNPAAAQMLGYKPHELLGRNMHEVIHHTRADGSAHDFHDCAVMRAIDALDTMRVSDEVFWRKDGTCFPVEYVARPQIEASEDGIRPGRAVGVVVAFADTTERRQLDRMKDEFISTVSHELRTPLTSLRAALGLVTGGALATRPDKMKQMLQIAIANTDRLVRLVNDILDIERIGSGSSELRPVMSAAEDLLERATKIHQGATFKHNVRFRVESNDVRVWADPDRILQALSNLISNAIKFSPPEGEITLTARYLDEQEAQFDISDQGPGIPQDRLENIFERFQQVDASDTRAMGGTGLGLAICRSIIAQHGGRIWASSPPGKGATFHFTLPTKAVAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX0</accession>
    <name>E8WXX0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">AciX9_2792</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581130.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2792"/>
    <dbReference type="EnsemblBacteria" id="ADW69815">
        <property type="protein sequence ID" value="ADW69815"/>
        <property type="gene ID" value="AciX9_2792"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2792"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_0"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="5"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="360"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW69815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="482" mass="52577" checksum="431D8CAC9B51A760" modified="2011-04-05" version="1">MDRIRRAKIVATLGPASSTPETFRALVRAGLDVARLNFSHGSHAQKSELIKMVRQVAREENKPICILADLQGPKIRTGKLVDHKPVQLVAGERLIITPHEMQGTAAKVSTTFTTLAENLEPGSRILLSDGLIELRVERVDGVDVVCEIVNGGTLGENKGINLPGIAVNVPSLTEKDEEDLIFCIGENVDTVAVSFVRTADDVRHVKSRLVALNSDAWIIAKLEKPQAIEHLDSILEVADCIMVARGDLGVEVPPEKVPAIQKHIIKRAAEYRKPVITATQMLESMIDNPRPTRAEASDVANAIYDGSDAVMLSAESAAGKYPVESVAMMAKIVIETEHQIRMDPPPRQHGRRAAKLSVAETICESMAHAAEDLDIAAIAIFTESGQTARLLSKYRPEPPIFALSPFEKVINRTMLLWGTYPILCERFEDSDALVTMAEQVLEKRGYVQSRNILGVVAGTRISSGATNFMRLHTVGDTGAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY78</accession>
    <name>E8WY78_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580024.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1653"/>
    <dbReference type="EnsemblBacteria" id="ADW68705">
        <property type="protein sequence ID" value="ADW68705"/>
        <property type="gene ID" value="AciX9_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1653"/>
    <dbReference type="eggNOG" id="COG2952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187465_0_0_0"/>
    <dbReference type="OMA" id="EWDILYR"/>
    <dbReference type="OrthoDB" id="1883396at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="10461" checksum="D52F853D99E9D8E8" modified="2011-04-05" version="1">MRITADKLNKLAHTVADSLAGIPECDFLEDRNTIRQEARKILTKLLADEMKLDAGARLKIASQRKIIVEGSQEWDILYRKYYNDEVKKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA6</accession>
    <name>E8WYA6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580052.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1683"/>
    <dbReference type="EnsemblBacteria" id="ADW68733">
        <property type="protein sequence ID" value="ADW68733"/>
        <property type="gene ID" value="AciX9_1683"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1683"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="316"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="461" mass="51177" checksum="AA2C972104F5A16E" modified="2011-04-05" version="1">MDENVRIAALLELEILDTPQEKEYDDLVHLASAICDTPISLVSLVDTDRQWFKAAMGLDVRETPRSLSFCAHAIRQPDLFVVEDAAKDRRFLSNALVTDNPHIRFYAGVPLQAPGGEPIGTLCVIDRVPRTLSEGQRAALTILGAQVQTRLTLRLKQKSLQQAHEANQELCHSLQATNDLFLSFMNHGPFASYIKDADGSMVFYNKYLAEASGVDEQAWIGLKDEEIWPAEMAAKFRSDDIAVLAGETAVEKDDVSPRADGTAAFWKSLKFPYVGQNGKRMLAGMSIDVTREVLHEAQAENALREKSALANQLVASRHMFRSFMENSPNITFVKDDQGRIVFYNAAVETFFGISATEWLGKTAQEILPEAMAERFVSQDHEVLSTGVNVDAQDEMVAADGEVHQFRKVKFAYKDLDGRTMLASVSQDITEETRQARALAQANAKLEFLATTDVLTGLSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG3</accession>
    <name>E8WYG3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="11" type="ordered locus">AciX9_2846</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581184.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2846"/>
    <dbReference type="EnsemblBacteria" id="ADW69869">
        <property type="protein sequence ID" value="ADW69869"/>
        <property type="gene ID" value="AciX9_2846"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2846"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_0"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="357" mass="38111" checksum="C34CF8F82BA7C9C1" modified="2011-04-05" version="1">MADERGKAIEAAMSQLEKQFGKGSIMRLGSKEAIVPIAVISTGSISFDAALGVGGVPRGRVVEIFGPESSGKTTITLQIIAEAQKAGGLAAFVDAEHALDPGYAKKLGVDIDNLLVSQPDYGEQALEIVEALVKSGAIDVLVVDSVAALVPKAELDGEMGDSHMGLQARLMSQALRKLTGTVSKSRTCLIFINQIRDKIGVMFGNPETTTGGKALKFYSSMRIDIRRIGAVKEGDVVVGSRTKVKIVKNKVAAPFRDAEFDILYGEGISREGDTLDLAVLHNIVDKSGAWYSFQGERIGQGRENVRNFLKTNRDVFGRIDGELRKKLGIGASSVPIPIPEMDEDGVEQAVAVVKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK7</accession>
    <name>E8WYK7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578933.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0533"/>
    <dbReference type="EnsemblBacteria" id="ADW67605">
        <property type="protein sequence ID" value="ADW67605"/>
        <property type="gene ID" value="AciX9_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0533"/>
    <dbReference type="eggNOG" id="COG5573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128080_0_0_0"/>
    <dbReference type="OMA" id="WDALILC"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16950" checksum="3C506610E42D900C" modified="2011-04-05" version="1">MNSTTETSISVDTNILFYSFDPRDVSKHEIAKRIMSFCLERKAQIALQVLAEFHHASVRKNVVSPLQADAIVQDFMQRMPVIATTPGDLATALDLRQRHGLQIFDCLILAVNNRSGCASFLSEDLQHNRKIGQITVLNPFLLTPSELDALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM1</accession>
    <name>E8WYM1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase with GAF sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0547</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578947.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0547"/>
    <dbReference type="EnsemblBacteria" id="ADW67619">
        <property type="protein sequence ID" value="ADW67619"/>
        <property type="gene ID" value="AciX9_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0547"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_0"/>
    <dbReference type="OMA" id="ENARNFR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="209"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="363" mass="39373" checksum="37743EAB1B7913DA" modified="2011-04-05" version="1">MDHLRVFHDVARSLTTTLELEEILLAIMDKMANFFGPERWSLLMIDPDSNDLYYAIAVGEDSKSLKGLRVPLGQGVAGWVASTGNPLVVPDVSLDPHWSAFARSHPDLKISSIACVPIRSGENTLGVIQLLNSKLDLLSEYSISFLRILCDYAAIAIQNARSLALIQELSITDDCTGLFNARRLYTMLEEQVTLIAPTSTNPLEKAHPLAFSLVFIDLDYFKSINDTYGHLVGSRLLAEVGSLLRRMVGPEASAFRYGGDEFVVLLPATGKDAAIALTLALCQGLRDATFLQSDGLTLHLSGSFGLATFPEDGASVHTILRSADSMMYDVKNSTRDNVAVVGRGRLMAAGGPISADRKASGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC7</accession>
    <name>E8WZC7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1767</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1767"/>
    <dbReference type="EnsemblBacteria" id="ADW68815">
        <property type="protein sequence ID" value="ADW68815"/>
        <property type="gene ID" value="AciX9_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1767"/>
    <dbReference type="eggNOG" id="ENOG5033K8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530447_0_0_0"/>
    <dbReference type="OrthoDB" id="2023981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="22347" checksum="8789410EE64254E0" modified="2011-04-05" version="1">MVPPKKVVNRRVHPSSIGQSERIRQNPIRQKLIVAFVAFHAFALFLFAIPFDIAPARAARELIAPYMRCVGLTDTWDMFAPNPKSMEQYLRAVVVTRSGQYKLYSFPRMEEFSLSQRYSKERYRKFSESVLCADCSGLWPDIAKAVARRYLNPADPPQSVLLVKYESPIDPQTGTTGADAAAKSVVLAQLPIKPEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD1</accession>
    <name>E8WZD1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580138.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68819">
        <property type="protein sequence ID" value="ADW68819"/>
        <property type="gene ID" value="AciX9_1771"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1771"/>
    <dbReference type="eggNOG" id="ENOG5033FY2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439761_0_0_0"/>
    <dbReference type="OMA" id="HVIMSAG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11101" checksum="F7D0E075056726B1" modified="2011-04-05" version="1">MVDETQDPKPHVIMSAGVHSAHEAAAGSPGAKTKGEISIWFFCGILMLAYGIVLLAQGSYEHFGHPHFPATVLQNLNPTFWWGVVLTVFGGFYTVRFRPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG6</accession>
    <name>E8WZG6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1806</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580173.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68854">
        <property type="protein sequence ID" value="ADW68854"/>
        <property type="gene ID" value="AciX9_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1806"/>
    <dbReference type="HOGENOM" id="CLU_1432710_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="21098" checksum="C3C8DC64A3B540D5" modified="2011-04-05" version="1">MPAHTDRPRFDQSQFADLRFRQDRRRAPRPIGVTLIATFQILKGTVLLLTAIMLRWYPGDVLGPQSIFYPVLYVATRGNTVVLQAASQGSNILPGFFFLLGSYITATGFGLLQLQKWARRTVMFNSSMTLLLWAKATLLNSSPSFGTSGLGGTSSDLTNFYILLFFDVLVFAYLIRSNAADVFEIRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG8</accession>
    <name>E8WZG8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1808</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68856">
        <property type="protein sequence ID" value="ADW68856"/>
        <property type="gene ID" value="AciX9_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1808"/>
    <dbReference type="HOGENOM" id="CLU_3184267_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="46" mass="5062" checksum="FFD19E6F9280139A" modified="2011-04-05" version="1">MKMMVAGLVGWVRLDVVKDERVKVVDTAITVLGTMLVAVSFVIWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL3</accession>
    <name>E8WZL3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ordered locus">AciX9_2964</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581301.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2964"/>
    <dbReference type="EnsemblBacteria" id="ADW69987">
        <property type="protein sequence ID" value="ADW69987"/>
        <property type="gene ID" value="AciX9_2964"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2964"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_0_0"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="15940" checksum="0A69B54D37E34372" modified="2011-04-05" version="1">MGTRRKSRELTMQMLFQGDLGKQTPEQVTKLFWSSVTDVDEETRGFAEDLYRIATSRGTEIDALIEEHSQNWRLERMPVVDRNLLRSAIAEMLGFPKTPHAIVINESLEVARRYAAPESIHFLNGVLDAVARDLLKARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN1</accession>
    <name>E8WZN1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2982</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2982"/>
    <dbReference type="EnsemblBacteria" id="ADW70005">
        <property type="protein sequence ID" value="ADW70005"/>
        <property type="gene ID" value="AciX9_2982"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2982"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065765_1_3_0"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234009" evidence="1">
        <location>
            <begin position="30"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="26817" checksum="E9326CBE3B7D8900" modified="2011-04-05" version="1">MHLTPLRQTRVLRTAIAAALLALAPFAHAAERITLKNGSTFDNCVRHIADGTNLRLFFRAESARGDDPDANYLDVPAASVASVEIVPDPPAPLSSPPSLLSSRSAAEGPASSLAASITPTIAEIHQLLTTSGAAHHIDVDLLASLMHAESAGNVKAVSRTGARGLMQLMPGTAAQLGVKDAFVPGQNVEGGTKYLDELLTRYHDDIALALAAYNAGPGAVDRYHGVPPFRETRAYVSRIIREFNARKSTLVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX6</accession>
    <name>E8WZX6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0717</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579113.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0717"/>
    <dbReference type="EnsemblBacteria" id="ADW67787">
        <property type="protein sequence ID" value="ADW67787"/>
        <property type="gene ID" value="AciX9_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0717"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NALNHRN"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234213" description="TonB_dep_Rec domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="401"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="939" mass="99503" checksum="22B831974152EEAC" modified="2011-04-05" version="1">MSCVCGVLLGAVCAVAGGQQSVTEASLTGRVSDPAGALVAHAAVTAREVTTNILHTAETDGQGRFRFPYLPGGDYVVEVHGAGFAEVRREVRLTVGAGFDLAVGLRMASSASAVEVKDEGAVVETDSSQIAGMVSEAEAHDLPFNGRNFLDLAGLVAGVSGTNTASTQLLAETSSVPGQGISVNSQRNFSNSFVVDGLSANDDAAGLAGNAFGLDTIREFQVVTSGGQAEFGRAMGGYFNVVTRSGSNALRGSVYGFLRNQRLNSENALSRSTLPLTQAQYGASLGGPIMRDKTFYFLNFEKRNLNTDGVIAISPANAAAVNAKLVAVGYAAPLLAVSGGNSGTTLFPTTLHTTYGFGRVDHEFGPRDRVNARYTHYELSSINARGVGSLSAVSAGSSVFDTNDTLAVSNIATLSSRTFNETRAQFTRDSYAAPPNDEVGPAVSISGVASFGRLSASPTVRMNYLGEVVDNVVHQRGAHTLKGGVDFLMNDTTITFPQSLRGAYTFSSLANFLAGTYNSSGFTQSFGTPVVGQTNPNVGMYVQDEWKASAKLTVNAGVRYDLQFLKSIQTDKGNVSPRIGFAWAPARDGRTVVRGSFGLFYDRVALRALANALLSAGNSTDLTKATLLSYSVSPLSTGAPAFPAVLTAPPAGVKVSLATMNPNIQNAYAEQASLGVEQQISSKTTVEMSYQHLRGEHLLADLNKNVNYDGSYINSSYANNKQYDSVGDSYYDGLEVSVVQRPVRYGSLRASYVWSKAIDDVGEFFFSAPVNNFNLREDRGRSDDDQRHRVSFNATVHSSMDAAHDWRGRVTHGWMLSGVLQYQSRLPFNIVSGTTSTQFTALRPCLPGADATACKQGRSGTLIGRNTGVGFDFYSLNARLSRTFVLSDRLRVEGMAEAFNALNHRNDMIPNATAGASGFAGATAVGDPRSVQLGARISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X034</accession>
    <name>E8X034_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1884</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580249.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1884"/>
    <dbReference type="EnsemblBacteria" id="ADW68930">
        <property type="protein sequence ID" value="ADW68930"/>
        <property type="gene ID" value="AciX9_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1884"/>
    <dbReference type="eggNOG" id="ENOG502Z8R4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342222_0_0_0"/>
    <dbReference type="OMA" id="FIRIETW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230509" evidence="2">
        <location>
            <begin position="27"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="940" mass="100132" checksum="A93D46554088AD8A" modified="2011-04-05" version="1">MAKLLSRLPALLLLFLCLSSAQNASADARFDLAGPKIDVRVTRNGVTLPIALVPNLQPGDQIWLHPDLPTTQSVHYLLIAVFLRGTTNPPPDNWFVRIETWNKKVREEGAFITVPDEAQQAVLFLAPETGGDFSTLRSAVKGRPGIFVRASQDLTEAGFEQARIEKYLAEMKQVAPGDPAALTEHSNLLARTLNLKPNPECFKRPIDQQFNCLTQTGNQSLLDDGHGQTVVASLSNGPGSDFINQASYTQLAGAGTYSAYVGAVVDLIRLTSSLHTAQYQYIPAIAFPDQSSLNLRLNTPPSFHNPKSVIVIGLPAVQKSTLPPLRPAEPNHTSCLLDPKMVLPIDGAPLVFSTSFAHQMVLHLNLPAGTAAPNGQPDVPLSPDAFQGGLTISQSTPGRRELPDAGTAPTPTRSDAPQPPKSTASLPVPTQPITGTVKGLWGFDSFIGPTLVLQATPGGNWHIVRSPSTPENLIAGQPNHLQIASSGTACIQSMQLEPGDQKIDWKVDEKADLPDHSEAHAATPTPETPSAKDVAVPPRAPVDSKPVTAEVKPAQPLPPPQPAVHPVDLTLNLQHAATPGSIQLAIQQFGQVKADQLGTKTFSEPAKIEAMQFHNGDSTVQLTGHGLDEVKQLTIKDAIFIPQAPAAADPDQPAPKPTSAALTLELAKDAKSPQVKNGEHLSAQVQLQDGRTVDVSTDALPPRPAVSILSRRITQATPSPIQLSSPDEVPLGSQLVFFLKSKAKFDRSEQIEISNADATLQTKLSIKENSLVLQDSHTILATLDPLKTFGPSSFGPFRIRAVAQDGTVGDWLPLATIVRLPTLSQLQCTGTHSQEPNASCLLTGQSLYLIDSIADSIAFTDPTTVPEGFVDTTLAIPHLTSPTFYLRLRDDPTAIQQVTLAMTPPPAPAHPTTTHASAVHPAALPPATQPAPTPQPAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A4</accession>
    <name>E8X0A4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="6" type="ordered locus">AciX9_3065</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581399.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3065"/>
    <dbReference type="EnsemblBacteria" id="ADW70085">
        <property type="protein sequence ID" value="ADW70085"/>
        <property type="gene ID" value="AciX9_3065"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3065"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_2_0_0"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="199" mass="21924" checksum="2ADD9A196071AD52" modified="2011-04-05" version="1">MSDTIRIGTVNRNTTETQIALTLTVDGQGTYNVSTGIRFFDHMLELFTRHGGFDLDLKVTGDLDVDQHHTVEDTGIALGEAFLEALGDKKGIMRAGYFVMPMDETLAVAAVDLSGRTAYAVETEVDVPIVGDLQTELVTDFFEGFARGAKCNVHVKTMYGRSNHHKIEAIFKAFARAMRGACSRDERMKEMLPSTKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A9</accession>
    <name>E8X0A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70090">
        <property type="protein sequence ID" value="ADW70090"/>
        <property type="gene ID" value="AciX9_3070"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3070"/>
    <dbReference type="HOGENOM" id="CLU_2973101_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="58" mass="6479" checksum="028C82F2BDD2D8FC" modified="2011-04-05" version="1">MRITNDAATLQRSAQQRFLRAVKLHRETMEEKAMMWGLIAFVALALGIVAYAVFAPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N3</accession>
    <name>E8X0N3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1938</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580303.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1938"/>
    <dbReference type="EnsemblBacteria" id="ADW68984">
        <property type="protein sequence ID" value="ADW68984"/>
        <property type="gene ID" value="AciX9_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1938"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_2_1_0"/>
    <dbReference type="OMA" id="WIWAETH"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="15598" checksum="2FAAC3380A713639" modified="2011-04-05" version="1">MKSKIDWEEAYAACEALTENEDSLTRDIVTGISEKWTLWTLAELAAEEAPLRFSRIMERVEGVSQKSLTKVLRQLERDGLITRKVFAEVPPRVEYATTDLALEMLELVHPLWKWAAANVAKFQAAQTSYDLRQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N8</accession>
    <name>E8X0N8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1943</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1943"/>
    <dbReference type="EnsemblBacteria" id="ADW68989">
        <property type="protein sequence ID" value="ADW68989"/>
        <property type="gene ID" value="AciX9_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1943"/>
    <dbReference type="HOGENOM" id="CLU_1487075_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="19191" checksum="5103A9C408348A29" modified="2011-04-05" version="1">MRELRLVAGAGIEPEKDSNTMSNHPAVTNQNFPRLSSFSSSALLVKKLRSLSGPAIVTSPGDLTATSLEHDAFGDNLEFVIHKDGQVWAHVTFCDEDHPFHTITLCKSLADLLPEFIDFVAEMAEESSINGDLPCPGGSAVGSLAGNVLKLDASITNLRKSTDRLMTALKLTGKDGAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q3</accession>
    <name>E8X0Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1958</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580323.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1958"/>
    <dbReference type="EnsemblBacteria" id="ADW69004">
        <property type="protein sequence ID" value="ADW69004"/>
        <property type="gene ID" value="AciX9_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1958"/>
    <dbReference type="eggNOG" id="COG4626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026632_6_2_0"/>
    <dbReference type="OMA" id="CGIIDEY"/>
    <dbReference type="OrthoDB" id="1527109at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005021">
        <property type="entry name" value="Terminase_largesu_Lambdalike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41287">
        <property type="entry name" value="PTHR41287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03354">
        <property type="entry name" value="Terminase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="555" mass="62594" checksum="ACAFC4E1D6E7ED6D" modified="2011-04-05" version="1">MTDYAALAHQYAQDVVTGKILACRWIRLACQRHLFDLDRIQSSEYLYKFSALKANKVCAFAEMLPLGGRFAAKGKNLKLQPWQCFLLACTFGWVHKTNGLRRFRTVYLYVPRKNGKSFLSAVIGLWMLMFDGEQQAEVYCGATTLPQAEYVFKPAQQIIRKCAGLQTFGAKNLASAIVFPASESRMSAVIGQPPDGSSPSCALLDEAHEWSNDILMSTMQTGMGARLQPLTLVTTTAGYNTAGPAKLMQDELQDVLEGIKEDDQLFGLIYGLDDKDDWKEPSSLVKANPNIGVSVGLEYLQSQLHKAIQTPRLQTATKTKHLNIWCASAVGWIDMDRWSRCKDENLSIENFKGETCWAGIDLANKIDLTAYVLLFRRVLNGIPHFYLFPRFYLPAAKIDDPANGHYRQWEGNGYLQSVPGEVNTFEELHEQIKKDRELYDVAEWAFDPAHAHLFVAKLLEEKLPLVEVPQTWKFQSEPMKELEALVLQEQLHHDGNPVMTWCIANTTVKYLNGDVIRPDRASYEKKKDGTDATLMALGRAQVAKPKKTAWAVEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y4</accession>
    <name>E8X0Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3157</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581481.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3157"/>
    <dbReference type="EnsemblBacteria" id="ADW70168">
        <property type="protein sequence ID" value="ADW70168"/>
        <property type="gene ID" value="AciX9_3157"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3157"/>
    <dbReference type="eggNOG" id="ENOG5032QY8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046513_0_0_0"/>
    <dbReference type="OrthoDB" id="200243at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="487" mass="54987" checksum="0E2BFE98655BAEA6" modified="2011-04-05" version="1">MPVKLPNNKTLKKAIETKAFRKSLQFLKGKSAALAPYRSLEDLFFEIEDHNPPSLAGVEKHLQEVCWRFRKTLYAHSVFIGGSVLDQIFYDRIRDPQVVDPVLSALTLIRTVGIHKPGLILYPLHSFSLLGIALLERFTSARLEFFVTEAEVCARAQTNSLGGTIEFLERAAESFGIKRAIPVESMEHYERSRPTKWLTRNTLLAVKAHVFSNDYYENHRFIILQLERASSLLFCLASLQGGFPVLKADTLFSSTRNNNWETQDIFHFLLFEPKAGSAKKLESRCIPMNARTIELAELCSVNVGINLKAWVHRRPLMERVCKALNAIEAGYRQSNVLSSVETVMHRVFKKIMQSLRYFRRSFRYTSGDDDIVMLAVALESLLTDSYAPGGGERLKRRAGLLLKGHPRRAICVEEIGKVYYARNQVVHTAEREQDVDVSIGREAYTLCLLRLVDRLPSLPQVAGNPIQQIIGDTHADPPALPMSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y7</accession>
    <name>E8X0Y7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ArdcN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581484.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3160"/>
    <dbReference type="EnsemblBacteria" id="ADW70171">
        <property type="protein sequence ID" value="ADW70171"/>
        <property type="gene ID" value="AciX9_3160"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3160"/>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012069_0_2_0"/>
    <dbReference type="OMA" id="AWENEDS"/>
    <dbReference type="OrthoDB" id="7103at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArdcN" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="32293" checksum="8756A65B73074C03" modified="2011-04-05" version="1">MTANAIDSKKPTTKQELIAANVKLLIEQLEAGHSEALTDYLTAMSRFHNYSFGNVLEIARQMPTATRVAGFWAWKNLGRSVNAGAKGIRILAPIVGVRRKKAVEAEKDITKQNERVLVDFRNAYVFDISQTNGVDLPSMHEVSGDPGENIERLAAFIKGQGIQLVYNPKIAPALGMSYGGRIAILPGQTKAEEFSTLVHETAHEMLHKAERRTATTKTARETEAEAVAFVVGKAVGLVNGTASADYIQLYHGNASLLAESLEVIQQTASVILGGLEPAVASEETPQQQEEDPELQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X118</accession>
    <name>E8X118_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579209.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0816"/>
    <dbReference type="EnsemblBacteria" id="ADW67884">
        <property type="protein sequence ID" value="ADW67884"/>
        <property type="gene ID" value="AciX9_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0816"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395282_0_0_0"/>
    <dbReference type="OMA" id="HDTEAYY"/>
    <dbReference type="OrthoDB" id="131940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234249" evidence="1">
        <location>
            <begin position="24"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="724" mass="78072" checksum="0678962EF3EB38B6" modified="2011-04-05" version="1">MALWRKGVGLGLAAVMALGPAMAAAQDAQQPQTFTLRVDSNIVLTNVIARDKKTGAVVKDLKGSDFTILENGKPQKMASFDYQNVDQAAVLAEKSTVSGKAKIADLLNRDLAADPKDLRDHRLMVFFFDISSMQPEDIDRAVQSAQDFVNKKMQPADLVALVSLDTGLTMDQDFTADKAALLKGLGKYNGTQSAGFAAGGTTGSTDATADDGSTFAADDSEYAALNTDKELYAIQQIAKSLERVDSRKSMLYFSGGLTRQGIENQASMRAATNEAVKANMAIYSVDSRGLEALPPVGNASTGSLRGTAAYSGASMQSNLQGNFASQETLGTLASDTGGKFFSDSNDFAPVFQQVQHDTEAYYILGFRSTNPARDGSFRHLTVKLNRNDVKLEYRPGYYAPADFQHSKTEDREVQLTEQLRSDLPATDVSVYLQALYFRMEDNRFFVPISLIVPGSQIPFLKNGDKDKATLDVVGQVKNAQGIAVGNIRDTVKLALDAAQQVQRKNIQYSTGFTLAPGRYHLKFVVRENQTGLMGSFETDLNVPDLKKVPMKLSSIVLASQRVPNADKKAVNPLIRDGVEWIPNIPHVFRQDQHLYFLYEVYDPAHQKAETAVVPAGMTRRPPIGGVRVLTSIEFLLGGVKVYETPLVEATAINSPERGAVSFQFDVPLAPLKPGTYVCQVNVIDDAGGSFSFPRLAMQVNAAGGVAPVSPAAVPTAAGAPAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X136</accession>
    <name>E8X136_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0834</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579227.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0834"/>
    <dbReference type="EnsemblBacteria" id="ADW67902">
        <property type="protein sequence ID" value="ADW67902"/>
        <property type="gene ID" value="AciX9_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0834"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745828_0_0_0"/>
    <dbReference type="OMA" id="PGCVEAY"/>
    <dbReference type="OrthoDB" id="1118028at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230544" evidence="2">
        <location>
            <begin position="30"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="395" mass="42137" checksum="91383C88ABC34926" modified="2011-04-05" version="1">MKRFLRVGSVLAVLTVAVPVVVSPGQAFAQAAAEKTAMVHGKVTQADGRPFEMGQIKFTQDRATPEKDRKYPFTFPVGAGGVFKGEGIPAGAWLAVVYADGKTVDYLEVTLKAGEDHSLDFDMTREEYLKALSPEVRAQIEETKKKNAGANAYNAKIADINKTLLQARADAKAGDTAKAVAEMQGLTQAKPDEGLLWVTLGEMQLADANAAAKAARAAHTSPMDAAIVQKYTDAGVSYQKGIDLAQAATKKQPEVVGLAYLNLGEADAKSGKFKEATDAYDNAVKANPTLASQAYYNEAAILFNAQKMDEAGAAADKAIAADPKRAEAYYIKAQTLIPKATMDEKTKKFVLPPGCLEAYQQYLDLAPDGAHAAEVKDLLTNLGQPVKNSYKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X138</accession>
    <name>E8X138_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579229.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0836"/>
    <dbReference type="EnsemblBacteria" id="ADW67904">
        <property type="protein sequence ID" value="ADW67904"/>
        <property type="gene ID" value="AciX9_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0836"/>
    <dbReference type="eggNOG" id="ENOG502ZP04">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187561_0_0_0"/>
    <dbReference type="OMA" id="ENANAMV"/>
    <dbReference type="OrthoDB" id="2025737at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="8360" checksum="7488DDF782174336" modified="2011-04-05" version="1">MADLEAEKLVMVGRYLDPSEAQMAKGMLESAGVECFLQGENANAMVPMAFRVRLEVQRKDLDEAKALLAATGGLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X146</accession>
    <name>E8X146_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0844</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579237.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67912">
        <property type="protein sequence ID" value="ADW67912"/>
        <property type="gene ID" value="AciX9_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0844"/>
    <dbReference type="HOGENOM" id="CLU_1445781_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233578" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="19412" checksum="6783C30B1BCC1399" modified="2011-04-05" version="1">MSKLFLLLLLSVSPQSAQLSGPIALNDPTLVQAAKEARKAGWHDVMTYPKQSFVVSWNGARLGTFLSLGARSAGASYQCLHSFVPDDGSVASSTVVTAGAGKLGTDICDHPSAVGILPSPPDQIRVGILYANSDYSGGNKDAGADAPSVSAAVVIDPGTRRMTLDVRATEILQRAGPSSLQAMRGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X175</accession>
    <name>E8X175_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1983</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580348.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1983"/>
    <dbReference type="EnsemblBacteria" id="ADW69029">
        <property type="protein sequence ID" value="ADW69029"/>
        <property type="gene ID" value="AciX9_1983"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1983"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655411_0_0_0"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="232"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="48952" checksum="997D2FD500B329EC" modified="2011-04-05" version="1">MANRKVAVYKQVRVGGVWDAGKREWQGGVWVKCPPWVNPSNNKPENDKVLVRGKMEVHPEGDWGIFFYEGTKRRWKKIGPKYNLAKNAADIKELALRGLSVGLKVEEADEKTLLKTAIASFLDPATNRPSAKWRPKTLALFTYDLEEFRRFVKKQYVEDLTSDDLHNFVDWIVRTPEQSDREHAHKTRKLRTQRTAVNKVAEVNQFYRWFMDLPPGKGLVKMEEFRDDDENDEPIIFQTEELEKFFAACKPAEHLLFTTFLRTGLRKGEMMNLAWRWVDLRYGIITVRNNKTTGHKTKTGKSRTIPILPDLLLRLTAHKEAATKLNQGADTDLVFCTRSGKPNDKMWDLCKKIAKRSGQDPSIFFVHRFRATYATNCLRGGMDVKSVQVLLGHSHKDFTSTSRYLAAAVTGDLKERFIAAQAKAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X187</accession>
    <name>E8X187_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1996</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580360.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1996"/>
    <dbReference type="EnsemblBacteria" id="ADW69041">
        <property type="protein sequence ID" value="ADW69041"/>
        <property type="gene ID" value="AciX9_1996"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1996"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_23_3_0"/>
    <dbReference type="OMA" id="YIEQERP"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="219"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="414" mass="47513" checksum="F5B9C96B4D5C8226" modified="2011-04-05" version="1">MIQELFVFESTRARQCAAPMLREREEYLDYMARQGVGRSRLRSMAAMLLNIVRFLELESSRAVSIEELQRGTERWLTEPGPRTARRPTKVSGMRFLLTAKNWLRFHNQLTIEALDPGPTEIIVRGFAHYLSVVRGLAPETTRIYRTRVSHFLEWALDRRASLSVISLSDVDDFILMKRASGYLPRSIVSFCGAIRMFFRYAEERGWNNSHIPLNLRGPHIPRYLSAPKGPTWKDVRRLINNKTETPVELRATAILYLCSIYGLRSSEVVGLRLSDFNWVSETFVVHRAKRGRVQQFPIQFEVGEAILGYLQRGRPQCVCRNVFVTLRPPYRTVRATTLWGIAADRMKKLGITSENYGGHALRHSCATELLRRGSSLKDIADFLGHRDMRSVSIYAKYDLKSLRQVASFSLAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C3</accession>
    <name>E8X1C3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2032</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580394.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2032"/>
    <dbReference type="EnsemblBacteria" id="ADW69077">
        <property type="protein sequence ID" value="ADW69077"/>
        <property type="gene ID" value="AciX9_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2032"/>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179277_0_1_0"/>
    <dbReference type="OMA" id="HHSCHEL"/>
    <dbReference type="OrthoDB" id="2036019at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="10185" checksum="E57830C3DCBDD58A" modified="2011-04-05" version="1">MTCTDFLAKLTDYFDGRVAPDLLIEVEHHIAECKHCEVVLDSTTKTINIYRDHEIYDFPPELEHRLTSAIMNRCIPGRAAAPAARQAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F3</accession>
    <name>E8X1F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3177</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581500.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3177"/>
    <dbReference type="EnsemblBacteria" id="ADW70188">
        <property type="protein sequence ID" value="ADW70188"/>
        <property type="gene ID" value="AciX9_3177"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3177"/>
    <dbReference type="eggNOG" id="ENOG5032XP8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174532_0_0_0"/>
    <dbReference type="OMA" id="KDRDFQE"/>
    <dbReference type="OrthoDB" id="1981428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="11560" checksum="DF8AD87737F29353" modified="2011-04-05" version="1">MPLLEVVQTRQISASVRLTDSTATQVDQYAAFIRASADDVVEQALAYVFSKDRDFQDFLKTPDARKITPTLRIRKPAANEVAEAAGKKQPSAASLPAQAPASLAGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G9</accession>
    <name>E8X1G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3193</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581516.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3193"/>
    <dbReference type="EnsemblBacteria" id="ADW70204">
        <property type="protein sequence ID" value="ADW70204"/>
        <property type="gene ID" value="AciX9_3193"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3193"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626657_0_0_0"/>
    <dbReference type="OMA" id="RIMNDGT"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="184"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="437" mass="49936" checksum="89489270A1B4CB00" modified="2011-04-05" version="1">MAVTNQRGYVTTRGKQWYGYYRKVVNDPATNEQKSVRIPVNLGLKSRMNKTEARHALEREITKQLGQTGSPTRIMNDGTVTFGWFVTNRFIPLKEAVWKPDTAETKKLLIQLDLVDPLGEIPLANFDKFSLQLHLNKLAATCSKDRVLQMRAYLRDIFAEAVDQDFLVKDPARKVKVPAQLRPTDTTTLTWDQLRLALSKLKLRDRLILELDMTNALRPSELFAFRWKRFDYPATTLTIAETVYKGKIRDWGKTKKSLSVIHLPQELADDLETWRLECEQQARDEFAKGERKSRNLSPEEFIFANRDGGFMDTGNYRKRVLHKLARDLNLPKLTFQVIRRTIATLAQKKGTVKDVQGVLRHSRTATTTDVYMQEIPESVQSTINSINEELRGTVGLKRKKPAKAGGAVHGRRNPATRVTQNDTKSLRGGTERLPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K0</accession>
    <name>E8X1K0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_3224</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3224"/>
    <dbReference type="EnsemblBacteria" id="ADW70235">
        <property type="protein sequence ID" value="ADW70235"/>
        <property type="gene ID" value="AciX9_3224"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3224"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_2_0_0"/>
    <dbReference type="OMA" id="DQDAFQM"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="35636" checksum="1B8FB0842E2151DC" modified="2011-04-05" version="1">MPHSTASLFTLRNDTLRVTLTNYGARIISILAPDRTGHQANVVLSHASLEAYEADRTAYLGATIGRVANRIAKGRFTLDGVEYQLPINNAPNNLHAGPEGFDRRLWTATEFPDAVEFTLTSPAGDQGFPGTLTVTVRYTLTASALQIEFTATTDAPTIVNLTNHAYFNLSGNASTSIEDHILQIAATHYTPKSAANVPTGELAPVAGTPFDFRQPQPIGSRIEDPILSLYEGIGYDHNFVLTPAPVAPAATVTHPPTGRTLTVHTTEPGVHFYTGDFLAQNGTHPNRTGFCLETQHFPDSPNHPHFPSTILRPGETFRSATTFTFTTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q1</accession>
    <name>E8X1Q1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_0903</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0903"/>
    <dbReference type="EnsemblBacteria" id="ADW67970">
        <property type="protein sequence ID" value="ADW67970"/>
        <property type="gene ID" value="AciX9_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0903"/>
    <dbReference type="eggNOG" id="COG4243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891601_0_0_0"/>
    <dbReference type="OMA" id="EKWCIYC"/>
    <dbReference type="OrthoDB" id="1857379at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12916">
        <property type="entry name" value="VKOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044698">
        <property type="entry name" value="VKOR/LTO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="17159" checksum="63904D216837EB11" modified="2011-04-05" version="1">MAPRILRFLIAALALAGLYVSVLALRVHNMDPSLAPPCAVTEKFDCGTVNHSRFAVFPPRAFDEDPASTKLHIPVATIGIAGYSLMLILALLGRFSLVLILAEIGFASASFLSYLEAYVIQKWCIYCLWSQTIVTTLLLATILAVYLTRRASRTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y9</accession>
    <name>E8X1Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2106</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580466.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2106"/>
    <dbReference type="EnsemblBacteria" id="ADW69150">
        <property type="protein sequence ID" value="ADW69150"/>
        <property type="gene ID" value="AciX9_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2106"/>
    <dbReference type="eggNOG" id="COG2308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703380_0_0_0"/>
    <dbReference type="OMA" id="RIYNRVI"/>
    <dbReference type="OrthoDB" id="386421at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="405" mass="46276" checksum="2A09A8B133FC7DD0" modified="2011-04-05" version="1">MLQPFRKSFNEEQFSAARYAALKERLDLRTRTKIEFRVCETPCFFPAELLEEMIETGRILTHQLIDSAEYMKRSGEAIPSAYRVPNDNPRPNFMTVDFGLVRGGDGKLTPTLVELQAFPSIYGYQDVLCEEYQRVYGLDERLQCRLGGLSGDEYWKLLGQTIVGDHAAENSVLTEVEPEGQKTLPDFHVYEDRLGITTVDIAKLKKEGNKLFYQKGGKWIRIERIFNRAIVDEIERKGVTPAFDYRDELDVEWAGQPNWYFRASKFSLPFLDHPSVPAAVFLDEWFDGVGRERLPADRESLLLKPLYSFAGKGIQFGPSDAELASIPADERHLYLLQERVRFEPVIDTPFGMTQAEVRIMYVWPEGAGEMRAVNSLVRLGRGLMMGVDHNRNQEWIGGSAAFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X202</accession>
    <name>E8X202_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2119</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2119"/>
    <dbReference type="EnsemblBacteria" id="ADW69163">
        <property type="protein sequence ID" value="ADW69163"/>
        <property type="gene ID" value="AciX9_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2119"/>
    <dbReference type="eggNOG" id="ENOG5032UDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064624_0_0_0"/>
    <dbReference type="OMA" id="DVITEST"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="28201" checksum="FA3E99586F4C6F17" modified="2011-04-05" version="1">MRGSCLSFVALAAVLMGGENGLAQSTLGNGGGILLAEAGHGGLSDHSVKGLPYSLVETFTSQRMLADGTKIDNTHEERIMRDSEGRERRETSLIKDGKPELTSIFIMDPLNRTSTILMPRMKIAHVNHLPQRKVLTQEEEARGAEARAKAEAARKEHQAQPGMEDLGAQAIAGVVVEGRRRTMVIPAGRMGNDREIKVVTETWTSPELKIILSSTTDDPRLGKMTAVVTEVKRGEPAAALFTIPADYKVEERSLGLGGLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X213</accession>
    <name>E8X213_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cna B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3245</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581568.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3245"/>
    <dbReference type="EnsemblBacteria" id="ADW70256">
        <property type="protein sequence ID" value="ADW70256"/>
        <property type="gene ID" value="AciX9_3245"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3245"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NDSWREE"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230173" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="453"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1036" mass="109787" checksum="3A38DA0BC9373F95" modified="2011-04-05" version="1">MKSTRSVFRGLVLSAPFVLGASVAFAQSTSSVAGTVTDTTGAAVPGASVLIHGIATGAERKTVTDGSGNFNAPSLQPGSYTVTVTAPGFSTFTLQQVTLEVNASATVNAKLTVGGSAETVQVESTQAVIEAQTSTVGQVIDREVVQQIPLNGRHFLDLTNLTPGTVVPPNNGSLTAPSRGLGSNGFVTAGAREDSNNFQINGINLNDMTQNQITFQPSINTTSEFKIINSTFSAEYGRSSGSIVNVSTRSGTNQFHGEGFDYLRNNYFDARNFFNRKGTRQNQLDRNNFGGALGGPILKDKTFFFISYEGLRQKQAILLTSNVPTTAQRAAFATSAAGTAYAQIINLIPVGTQSTNAAGQAVATASGSAPGPVKTDQFSGDLFHNISKSDTLHLYYAWQQDARTEPNLQGNTIAGFGDHRGAHRQIGTINEIHVFSPAIVNEARIGFNRIAISFNENFLGNSSTYGINNGVTLPLGLPQISVTDLGLNFGGPSGFPQGRFVTTGVFSDTLNILKGKHSIKVGGEFRRFEGNNFSETAGTIAFSTTANFANGLANTFSANSSNVVSRIFDSSVAGFVQDNWKLTPRLVVELGLRFEWNGTFTEGAHRFVNFLAASDTLQQVNQPYNQNYNYDPRVGFTYDLLGNSKTVLRGGFGILADQPNEGVASGLAGNPPNSSPVSLTGGTSSTGVGGFAVGSLYTAAALVGLTPSAVSPNLRNAYMESYNLNLQQDLGFGTVLQVGYIGSSGRHLRDPLNINQFNHPTPTTNVRPFAALSTASLIRPGASLGNITQVANASMSNYNALWVTARKQLRGGLDLNASYTLSKSLDDNSLGTNGHQDSTNPAGDYGRSDFDTRHHFVFSGVWTLPFHGNRFKEGWLLANITQVQSNNPINVVTSNTSYTGSGNIRPTLIGKYSTGRGALLTSGNIPWITGSVCTTPTAGCTFYTQATGFGNLSRNALNGPDFSDTDLSLQKTTKIAESVNLVLRLDSFDLLNHVNLANPNLTGATTGTFGQITATRNQVGDAGSSRQLQFAGKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F9</accession>
    <name>E8X2F9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ordered locus">AciX9_2139</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2139"/>
    <dbReference type="EnsemblBacteria" id="ADW69183">
        <property type="protein sequence ID" value="ADW69183"/>
        <property type="gene ID" value="AciX9_2139"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2139"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_0"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="OrthoDB" id="76567at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="88"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="208"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="418"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="591"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="770" mass="85756" checksum="27731A3B9043DF8F" modified="2011-04-05" version="1">MTSKRTKSQQSHEPDAAQELAPVEMTPTNMATEAALAGSEEDGVDLAPKSSAAAKRAVKSAAKQISAGKGGAKRAGKKAAETPVESRYFNRDESWLRFNQRVLEEAQDEKNPLLERVKFLAITASNLDEFVEIRVAGVLQRIEDGLGLTQGADEGGLTQEERLARVSGQMAAFVAAQYRCWNEQLLPSLKAAGVHVLRWGKLSPEARTHALKFYEDEVDPLLTPVTIDPSHPFPRVLNKALCIALLLRHKRRGPAGLRPGKVLGVVTVPRSLPRLVCLPSPEGRQDFIFLHELIESQVEKMFRGYEVLGKAAFRVTRNSNLYMQEEESRSVLESVRAELHNRRKGDAVRLEIETSAAEEIVDGLRTNFELDEQQVFKTDGPVNLSRLMNLYSEAKLPGLKYPAFSGKQYKLSGKNEDLFAELREKDVMLHHPFDSYRTVEEFIGAGARDERVISMKQTLYRTSKDSPIFRALIEAAQSKDVTVVVELMARFDEDSNIRWARELEDAGVGVFHGIFGLKTHCKLALLVRRDADGHVRRYAHLGTGNYNPVTARFYTDISLQTSKPEMTVAVQKVFNYLTAESEAEADAYQPLLVAPLTLSTDLIRLIGREADHAKAGRPARIVAKMNGLLDGKTVEALYAASEAGVEVELIVRGMCSLRPGVKGMSERIKVRSIVGQYLEHSRIFEFANGGKAEVYCGSADWMPRNLYERCEVVFPVTEPALAKRLREEILGAYLRDNVKARMLLASGEYVRAEAKGERFSAQEYFMGLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G3</accession>
    <name>E8X2G3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2143</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580503.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2143"/>
    <dbReference type="EnsemblBacteria" id="ADW69187">
        <property type="protein sequence ID" value="ADW69187"/>
        <property type="gene ID" value="AciX9_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2143"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_0_0_0"/>
    <dbReference type="OMA" id="GQGFYKK"/>
    <dbReference type="OrthoDB" id="82358at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="196"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ECH_2" evidence="6">
        <location>
            <begin position="507"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="818" mass="88703" checksum="58F67FFC0EE646DC" modified="2011-04-05" version="1">MPHPNPLIACVAVLGAGTMGSRIAAHIANAGLPVILLDIVLPDKPRNFLALSALDALRKAKPAAFYTPDAARLITPGNFEDDLALLKDCDWIIEAVAENLEIKRALIARVAEHRKPGSILTTNTSGLPIASIVEGFPEDLRAHWFGTHFFNPPRYMRLLEIIPTAESSPEAVDTIATFCDKRLGKTVVPSRDTPNFIANRVGTFSMLNAIRLMQEQGLTIEEIDALTGAPLGFPKTGTFRLGDLVGVDVLAHVATNFAAQSARTHDERADVVLPPFITHMLEQKWLGDKTQQGFYKKAGRDEQGRDLRHVLDWQSLDYHPATRPKLAALEQAKPIEHLGTRIAQLLHADPKTDKAAAFYWPFLTELFTYAANRVSASDNEPAATIVEIDAAMKAGFNWELGPFEMMDAAGPRATTYRMLAENRPVSTNVERLLNYPHAITEPGPTWYKDDPTTPSGRQFFDPTTATYKPVPIPEGVSSLATLKKSHGVVKKNSGASLVDFGDGVAAIELHSKMNALGGDIVSFITQTLKPTSEAVANFTSFVITGESNNFSVGANLMQLLLAIQDEEWDDIALMVRGFQNMTQLIKFCPRPVVVAPYGMCLGGGVEISLHAAARQPHAELYMGLVEAGVGLIPGGGGCKEMLLRTIESGTSIRPDARGEGVEIFESLKKNFETIAKATVSTSAAEARTIGFLRPSDAITMNRDRLLTDAKLRAQSLTAAGYTAPSPQLAVPAPGTNALATLKLAVWTLREGQYISAHDAKVANWAAYALCGGNVTPGTPVTEQYLLDLEREAFLSLCGEKKTQERIAFTLKTGKPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I2</accession>
    <name>E8X2I2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase subunit III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2162</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580522.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2162"/>
    <dbReference type="EnsemblBacteria" id="ADW69206">
        <property type="protein sequence ID" value="ADW69206"/>
        <property type="gene ID" value="AciX9_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2162"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_1_2_0"/>
    <dbReference type="OMA" id="FLDLLWV"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="21835" checksum="C14098624E4A104E" modified="2011-04-05" version="1">MSSQTTTGSSSFAETYAAHPSKGLVGILCLIVAETTIFVIFVVAYIFYLGKSLSGPAPHEVLSLPIVATVCLLSSSLTVHQGVAELRKGKSAAATFWIGITALLGLIFLGFTGAEWFDLIVHHGLTIKTNLFGTTFYSLVGLHATHVVVGLIMLLLVTFFGLNKQLEERHAERLEILSLYWHFVDAVWVIVFCVVYLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M1</accession>
    <name>E8X2M1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2201</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580561.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2201"/>
    <dbReference type="EnsemblBacteria" id="ADW69245">
        <property type="protein sequence ID" value="ADW69245"/>
        <property type="gene ID" value="AciX9_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2201"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_0_0"/>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131079" checksum="EB3E4A953295C2D3" modified="2011-04-05" version="1">MGAEFTHLHLHTDYSLLDGACDVDKLVAHVDKIGQKSVAMTDHGNIFGAVHFFNSAKKKGIKPILGCELYICQAEDHRAKGDGDKYNHLLVLAENQEGYRNLVRLTSEAALHGFYRKPRVSKNFLAKHTEGLIGFSGCLAGEVSQHLMAGDYDKAKTTAGGFEEMFGRGNFFLEVQDHKLAPDKAVIEAMFRMEKDLDIPLIATNDSHYIEDQDARAHEVLLCVQTAGSMNDPKRFKFDTEEFYIKTAEEMARFFPDHPEVLSRTMQFPERCNLELNKVDNPFPDFPVPAGETLESYFEQVCREGLKKRFETNVAHLERTGKLRKNKTDYEARLNREIDCIKAMKFPGYFMIVWDFIRYAREQGIPVGPGRGSAAGSLVAYCMEITDVDPLQNELLFERFLNPERISMPDIDIDFCMNRRGEVIEYVQRKYGKDQVAQIITFNTMAAKAAIKDVGRALDMPYGEVDRIAKMIQGRIGVTISEVLKDNGPLTKAYESEPQIRELIDTALRLEGLVRGAGVHAAGVVIAPSPLTELVPVTRAKSEEIVTSYDMGAIEKMGLLKMDFLGLTTLTVIDDALKLIKLTRGEDVDLATISLDDAKTYEQVFHRALTSGVFQFESGGMRDVLRRYKPNTVEDLTALNALYRPGPIQGGMVDEFIERKWGRRAVEYELPELEPILRETLGVMLYQEQVMQISNKLAGFSLSQADMLRRAMGKKDVAEMTKQKVKFMEGAAENKHPKAVAGNIFDLMAKFAEYGFNKSHSAAYALLAYHTAYLKTHYTVEFMAALLTSETSKPENVVKYISECKEINIAVVPPDVQISQPSFTPQDGAIRFGLAAIKNVGHNAIQSIIDARGALQAEGKDGFASLWEFCEKVDLRLLNKRVLESLIKAGAMDCFGKRAAVMAALDNAMDRAQKAQKDKAAGQHGLFFGGIFDSDVPAAGAAVEALPNAPEWDEHTRLQNEKDVLGFFVSGHPMDKYREKLRNMKVVDTATACEMKPEPQQFRRGGPEPNEISIAGVITGLKVAKSKRSGEMYAQAVLEDTTGKIELICFPQSYEKMAEKLKITVPVVIRGSLRGEEDSAPKLAISGIEALEDVKLRLPEALRIKVPLHSSDAELLNKLARLFTESPGRGKLLLDFEEPGEFCAVLEPMKVMVAADRLFIDRVEELVGRGAVRVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M3</accession>
    <name>E8X2M3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2203"/>
    <dbReference type="EnsemblBacteria" id="ADW69247">
        <property type="protein sequence ID" value="ADW69247"/>
        <property type="gene ID" value="AciX9_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2203"/>
    <dbReference type="eggNOG" id="COG3755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825771_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="36868" checksum="77D05A1AD5C7D6DB" modified="2011-04-05" version="1">MNVCLGLLGRKALGMFVLALLVGGRMVWAQDAPSASQAPQSHMEAPPVQQTGAPIVRIEPESSYDKTIFLKTFPVADLAFLKQYDGAPAKDLIHDKQFKKVLKDVLPGCMFHYGKDMPLDEAVDMVMKDSRVPVRIRDGRYVVVSGLGGPYLSGRGFVWIDMQDGVALGGFYFHPTNGEPTPTLAIYSKQIKEDQVAMSELPPVFGQDMAEWQNESRVPTVTTQYFLTGKNKRVLLEHDEDYCSPADGMVAPAGDCEELNADAADADEQAAYYLDQVHYATNATAWMIGADQVAWIGVRERTCGGVVDPLGCRIRVTREHTHVIIGRGPVGHGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S6</accession>
    <name>E8X2S6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ordered locus">AciX9_3365</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581685.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3365"/>
    <dbReference type="EnsemblBacteria" id="ADW70373">
        <property type="protein sequence ID" value="ADW70373"/>
        <property type="gene ID" value="AciX9_3365"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3365"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_0"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="682"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="893"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="577"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="960" mass="106395" checksum="D54E8F2AD8026960" modified="2011-04-05" version="1">MSIEETQPSAPTELAKAYDPSTIEEKWADYWVEKKLFDTPAAAPGTAAFTILLPPPNVTGVLHIGHMLEHTEMDILTRWHRMSGETALWVPGTDHAGIATQLMVEKQLAAEGKTTRAELGREAFVARVWEWKQKYGSAITDQMRRLGDSVDWSREYFTMDDDLSHAVTEAFVRLHEQGLIYRGAYIVNWDPVLQTAVSDLEVESEERTGKLYSIRYPLADGTGSIVIATTRPETLLGDTAVAVNPTDPRYQHLIGKTLSLPLTNREIPIVADEWANPEFGTGAVKVTPAHDPNDFAIGKRHDLPSLTILDKTAHIDLPGSPYHGLDRFEARKQIVAELEAIGLLVEIKDHAMTVPVSQRSGSVIEPRLSDQWFLAVNKAPSTGGESIAAKAIAAVREGHIKFTPDMYEKTYQQWMENIHDWCLSRQLWWGHRIPAWYCANRHITVSRTTPTACPTCASTDLTQETDVLDTWFSSGMLPFTVFGWPKVQGPGSSAQGSANLSPGPLSLSPDLASFYPTDLLVTGFDILFFWVARMIMLGTHFMQEVPNADGTPRTLADSVPFREVYIHALVRDADRQKMSKTKGNVIDPIEIITKYGTDAVRFTLASQASPGTDIAFNEARTEGYRAFANKIWNAARFLFMNIERAKEAGLSTTLVTNLDIPTTLGAPRPASGTWVGAPIETQWIFDRLSETSKTVDQALKDYRFDEAANAIYQFFWGEFCDWYLELVKVRLDFSGENNAATEQSLSALVTVYEAALRMLSPFMPFITEEIWHVLYAALGLEAPAKSIALTRFPQHEDYPQGGIAATDMTLLQEVIVAIRGIRKETGVPEKEAAPVLIFASNPHIGLMVQSNADILAKMARVSAVSVADSPLSGSGTKSTPSFDVQVVYERQIDVPAERERLTKDLAKYEKGLQAADKQLGNKGFMGRAPAHIVEGLRKQHAETLMLHNKTKATLEALPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V4</accession>
    <name>E8X2V4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1025</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579411.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1025"/>
    <dbReference type="EnsemblBacteria" id="ADW68088">
        <property type="protein sequence ID" value="ADW68088"/>
        <property type="gene ID" value="AciX9_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1025"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_0"/>
    <dbReference type="OMA" id="NEAVMHM"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="41074" checksum="58B01C6B366A7F75" modified="2011-04-05" version="1">MSTVVAPKGLEGIVATTSSICWIDGDAGVLSYRGIDIHELASKSTFEETTYLLWNGRLPSGSELKAFSAELAAARVLDPKIIDLLKSVPTSASPMEVLRTAVSLASIYDVDEKDSSHDANVRKSFRLTAQIAMIVALFDRIRKGKEIVEADKSLSHAANFLWMLNGEKPSETATNAFDIALILHADHELNASTFAARVIAATLSDMHSAITGAIGALKGPLHGGANEATMKLLYAIDEAGADPVEYVRNMFATKQKISGFGHRVYHTEDPRATHLRRMSGELGAAAGNTKWFDMSQKIEAFVKSEKKLNANVDFYSASTYTTLGIDIDLFTPIFAISRISGWAAHVIEQHDDNRLIRPRAEYTGPAYPAPYTPIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X346</accession>
    <name>E8X346_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase regulatory domain, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2228</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580586.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2228"/>
    <dbReference type="EnsemblBacteria" id="ADW69270">
        <property type="protein sequence ID" value="ADW69270"/>
        <property type="gene ID" value="AciX9_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2228"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037603_1_1_0"/>
    <dbReference type="OMA" id="ICHGVIS"/>
    <dbReference type="OrthoDB" id="1388725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018773">
        <property type="entry name" value="MeTrfase_reg_dom_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10119">
        <property type="entry name" value="MethyTransf_Reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="3">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="MethyTransf_Reg" evidence="2">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="526" mass="57705" checksum="0556D80517E8B92C" modified="2011-04-05" version="1">MPSPSNAHQTPSIPDPHDAVPYPGTAYPATHPDNLAVQALLHGLTPTPVAHCRVLEIGCNEGRNLIPMAYAIPTSHFVGFDLAAQPVARGNQRIQQLGLTNIHLFQADILTLQDTHPDLGLFDYIIAHGVYAWVPQHVADALLALCRRLLTPNGVAFISYNALPGGHLRTMIREILQHQPGPGPAPDQDPTQSLTHSLDYLKFIASTRPEGDPYRTLFERELTRLPEKGAQVVFHDELTASYNPVSFTTFVTHAAAHSLQFLADATLPLPNDPCFNPAIAGPAKTFANGDPIAEEQSLDHARMRMYRETLLCHQGHDITWDLRLDALAHLRLSSRAELQPPAASDEDDDAEYDDGSRNYKLPDALHKGAGMDTRSPALILIMDHLIAAWPESVPMAQIERLLAGQGITFTAELVTLLLRLIFARMIHLHTWAAPVSATLAARPLVSHISRFELTQHDRLINLAHSVITLPDPIVRTLLQLLDGTRDRAALLEALHTTHPDIPLETLAQGLEPALHLLNRAAVILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X371</accession>
    <name>E8X371_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2257</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580611.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2257"/>
    <dbReference type="EnsemblBacteria" id="ADW69295">
        <property type="protein sequence ID" value="ADW69295"/>
        <property type="gene ID" value="AciX9_2257"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2257"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_5_1_0"/>
    <dbReference type="OMA" id="RATYYIT"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14551" checksum="C2009A3F756A1475" modified="2011-04-05" version="1">MNERQNFAGTSEYEDVIGFSRAVRVGRHVMVSGTGPVGCDDADVAGQTDQCLTLIAAALKSAGTSFEHVVRTRMYLTDRNDWEAAGRVHGKFFKLVKPAATMVVVAGLIDPRWKIEIEADALIPGDATDAPGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X375</accession>
    <name>E8X375_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69299">
        <property type="protein sequence ID" value="ADW69299"/>
        <property type="gene ID" value="AciX9_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2261"/>
    <dbReference type="HOGENOM" id="CLU_2584808_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="8712" checksum="038B36B69F627658" modified="2011-04-05" version="1">MQMPRSSFAPAPVTGIIITTATTITAAITARLHTQRIEKPRRQAGLLYFNHHYAVAYFTIRQNVSGSKLAPPTSAPSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X397</accession>
    <name>E8X397_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581710.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3392"/>
    <dbReference type="EnsemblBacteria" id="ADW70398">
        <property type="protein sequence ID" value="ADW70398"/>
        <property type="gene ID" value="AciX9_3392"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3392"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008973_1_0_0"/>
    <dbReference type="OMA" id="DHAHIFI"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="337" mass="38559" checksum="3531349293AA53A7" modified="2011-04-05" version="1">MFYSIRHLTKFLYDKPVSESMMETRMHPRSDQNQRCLTFHLSVSPRCRVFSYRDHLANHVHHFDIPGAHPQLVIVAESLVEVQPSIEIPSFLAPDAWRDLDTMIHEGDYWEFLYPSEFAIATPLLDDLAKSLDVRRRDDPLMLLHDLNRQLYEYFGYKPKSTKVDSPIDVALESRQGVCQDFAHIMITLVRDKLKMPCRYVSGYLAHRATDPNHSLDSDRSAQSASATHAWVEVLMPHFGWVGFDPTNCLVAGDRHIRTAIGRDYADVPPTHGMFRGRANSELTVAVRVTPSEGTPPLDQDLPVPEDWSILVERAQALPEIPPPLTRQQQMAQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C1</accession>
    <name>E8X3C1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase hexapeptide domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3416</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581734.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3416"/>
    <dbReference type="EnsemblBacteria" id="ADW70422">
        <property type="protein sequence ID" value="ADW70422"/>
        <property type="gene ID" value="AciX9_3416"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3416"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_7_1_0"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="18725" checksum="1113B1D48936D60A" modified="2011-04-05" version="1">MIRSYRGVKPIIPENCYVDVSAQVLGDVILGEQASVWMNAVIRGDVNAIRIGAGSNVQDCAVLHGMKDLYPVLIGEHCTIGHNATVHGCVLEDEVLVGIGAVILNDARIGTGSIIAAGAVIPEHTVIPPRSLVAGVPGKVRREITDEDHRLILMYANNYLGYTKNYLEELASGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U2</accession>
    <name>E8X3U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580686.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2333"/>
    <dbReference type="EnsemblBacteria" id="ADW69370">
        <property type="protein sequence ID" value="ADW69370"/>
        <property type="gene ID" value="AciX9_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2333"/>
    <dbReference type="eggNOG" id="ENOG50349EA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893606_0_0_0"/>
    <dbReference type="OrthoDB" id="2232057at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="32243" checksum="D0487F40FFA2E590" modified="2011-04-05" version="1">MRRKVWLGFGLFCFLAGSRWLLEQAVPAPVTSLVREAMHHGLLVLIFAAWAVQRREGWAGKSLMDWLEIAGAAALVFVLPDLLINGAAGAVTSLSETLVFLLVPVVVVFVVAQQASGFGVDDGARGLLGPALAGLAGAGLMIPFTMPPSVAGKVWLGALVAGAVLAGIATVRVHALLRGTGIMAATAVVSGVIAVLSGVAASSDWRGLAQMDGRGLLVEAAIAVFVDGPLLVLAVWLLREMPPVGFVVRYFLVLLITIVESFIVLHPSVSWYTALGAVLMAAAVWLLLRGAAGLASKADSEGSPVKLRGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X5</accession>
    <name>E8X3X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581794.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3478"/>
    <dbReference type="EnsemblBacteria" id="ADW70483">
        <property type="protein sequence ID" value="ADW70483"/>
        <property type="gene ID" value="AciX9_3478"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3478"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_3_0"/>
    <dbReference type="OMA" id="LEPGNRW"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="44582" checksum="7E29A51176F9EB6B" modified="2011-04-05" version="1">MSEFDVLVIGAGMAGLSAGRALAEAGLRVVLLEGRDRVGGRILTVRAGDEVVEMGAEFVHGRPQELWDLIGEAGLQTYERTGEFLRAGDGGFESEGDEDEEPLEDLKTYEGPDLSFAQYVEGLGLSATKKVEAIGYVEGFNAADAREASIIGLGRQQVAEDAIEGDRLWRIKDGYDRVPEFLLERFEVAGGRVMLGACVKEIAWERGRVVVKTSAGEFRAAKAVVTLPLGVLQAGVVTFSPEPAGVMAAARRMRMGQVCRFTLVFKKMLWPEGMSFLMAREAMPPVWWSAWPSAGLTMTGWVGGPRADELMGDMDLQARGMAGLAAALGVSEDVVSKELIGVHVHDWASDEFARGAYSWVPVGGVDASAEMGVPMEETLFFAGEHTDTTGHWGTVHAALRSGLRVAGQVLESIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y7</accession>
    <name>E8X3Y7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3490</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581806.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3490"/>
    <dbReference type="EnsemblBacteria" id="ADW70495">
        <property type="protein sequence ID" value="ADW70495"/>
        <property type="gene ID" value="AciX9_3490"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3490"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_2_1_0"/>
    <dbReference type="OMA" id="ARYNPWR"/>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="599"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="864" mass="93026" checksum="E30F206BC0D6C3C7" modified="2011-04-05" version="1">MIATVLTLLTVLAIWSLCRSERPAWLPVAAIWLTLGLAAAEWQPSPASIALTPYTDGLSRHLTARIIRIHTLPPEAPTPDADQIPVWEATDSTPETENQPQAISADLALASIEQVTPDTSTEVPITGTIRATLYSATPIALRCGQPITATLRIKPLERYRDPGAWQYADYLATQGVVAHASAPASDIHATAPPIRTLPCLLADSQSWAAARLLAFTQSPQNRGLPELVRLSQQDAGMLNAMLFGDRTVLNHTLRLGFERTGSFHLFVVSGLHIALLAGAVFWLLRLIRTPRWLATLLTLAAATFYAALTGFGQPAQRSLAMVAVFLLARLLSRDRDGLNALGAAALALLLWDPSTLFDASLQMTILAVIAIAGLAHPIAQRTFLPWAAAARQAFRPRRRPLPPALAQLRLTLELFGEHLSAASHLKPIRYIPAQAFRLILWTLELALVGIVVELVMALPMAIFFHRAAVFALPANMLVLPVIAILAPAAVATFVASLINPWLAILPGTLTATLLHTLTSVISHISHLKSADVRIPPPSPWIAAAALAAWLTCCWAVRRSRAGTVITAAVLPLIAVAILWPEPPILTPNTLEITALDVGQGDSLLAVSPEGRTMLIDSAGPIGRHGQSEVLSTFDIGEQVVSPYLWSRRLRQLDIVVLTHAHTDHMGGLPAILQNFHPHELWVGIDPHSALYAALLAQAARLNIRVRHLHTGDHVQWGSIPIEVLSPSPTYLNPGPPKNDDSLVLHMQYGQSSALLEGDAERPSEAAMLAAKLIHPVTLLKVGHHGSNTSTIPAFLAATAPIDAAISSGRGNPFGHPRAEVIGRLAAQHTHLFRTDELGLTTFLLTPDGRIREVVNSTPLPVHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z9</accession>
    <name>E8X3Z9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">AciX9_3502</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581818.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3502"/>
    <dbReference type="EnsemblBacteria" id="ADW70507">
        <property type="protein sequence ID" value="ADW70507"/>
        <property type="gene ID" value="AciX9_3502"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3502"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_0"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="34235" checksum="3BC704628A36CD33" modified="2011-04-05" version="1">MTTAAGYALGSLLTVDGLAVSEVSRILALTSHLEAMAPEERSQVLKGRRVALLFYESSTRTRTSFELAAKSLGATTTLVSDKSSSIEKGESLKDTGLTLRALGAECIILRHPAGGAPFVLAQTTGLPVLNAGDGMHQHPSQALLDLRTILSRLGRTDKPVDEHVLDGVTVTIAGDIRHSRVARSNAMLLPRLGARVLLCGPPELLPEEALGLGDGIEIVRDFDAALKRSQVVMMLRIQRERLAGLEIDLADYIIHYQLNEERLQAYAPRAVVMHPGPMIRGLEIQGEVADSAQSAIEEQVRHGQAVRAALLVRALEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X449</accession>
    <name>E8X449_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0018</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0018"/>
    <dbReference type="EnsemblBacteria" id="ADW67109">
        <property type="protein sequence ID" value="ADW67109"/>
        <property type="gene ID" value="AciX9_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0018"/>
    <dbReference type="HOGENOM" id="CLU_2129931_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="13015" checksum="E278F8107957E9B7" modified="2011-04-05" version="1">MRRNLALILLFGWVPVALGVFLLSEFWLQQPFLTLGVIIGWFVAACGMIWWAGEFRCPRCRRRYGAVGSRKGVNLIWRGLFDSICNNCKLRKFENFNSEGSNPGSLDRRMARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A7</accession>
    <name>E8X4A7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1171</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579557.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1171"/>
    <dbReference type="EnsemblBacteria" id="ADW68234">
        <property type="protein sequence ID" value="ADW68234"/>
        <property type="gene ID" value="AciX9_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1171"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_0"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14246" checksum="D681576ADC999FFF" modified="2011-04-05" version="1">MSDAIRLDHVGVAVRSIAAARGFYELMGFEVGAAEEIAHEAVRVAMVPMDGSRVELIEATAEDSVIGRFVARRGEGVHHLAVRVDGVDAEFERLRAAGVRMASENVKVGAGGHRYFFVHPESTGGVLMEVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D6</accession>
    <name>E8X4D6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579586.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1200"/>
    <dbReference type="EnsemblBacteria" id="ADW68263">
        <property type="protein sequence ID" value="ADW68263"/>
        <property type="gene ID" value="AciX9_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1200"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_1_0_0"/>
    <dbReference type="OMA" id="HCKAFRR"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016793">
        <property type="term" value="F:triphosphoric monoester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="68"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="383" mass="43221" checksum="2F30524E61DE35F5" modified="2011-04-05" version="1">MTNLSSACAVNDVAGDVLLTRAYPAPSHPYRTPFQRDRERIVQARAFRRLAGKTQVFTSRASDHFRSRLTHTIEVAQIARAVACALGLNEDLAETLALVHDIGHPPFGHAGERALDRCLQKHGRRFDHNLHALRITEHFEQRYAAHRGLNLTLGVREGIVKHSKDYSAEQYPELACYFLDQAPPLEAQIIDLADEIAYLTADLDDGVESGLLEISHVRTNVEILARCFQIVERDHIGLAEKFLFHEALQLMQNTLTNDLIANTRANLSAAKLTSLSAVRAHKARVATFSALVESERLQEKRYLYDTLYTCEALEIEHAKAEEVVTALFEFWMENPEELPEGYGEEVKAEGLARVVADYIAGMTDAYILLQYAHIKRNPRLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S1</accession>
    <name>E8X4S1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine ammonia-lyase small subunit</fullName>
            <shortName evidence="4">EAL small subunit</shortName>
            <ecNumber evidence="4">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eutC</name>
        <name evidence="5" type="ordered locus">AciX9_3556</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="4">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EutC family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581871.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3556"/>
    <dbReference type="EnsemblBacteria" id="ADW70560">
        <property type="protein sequence ID" value="ADW70560"/>
        <property type="gene ID" value="AciX9_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3556"/>
    <dbReference type="eggNOG" id="COG4302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068224_1_0_0"/>
    <dbReference type="OMA" id="ADRNCVS"/>
    <dbReference type="OrthoDB" id="1115166at2"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00601">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009246">
        <property type="entry name" value="EutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042251">
        <property type="entry name" value="EutC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042255">
        <property type="entry name" value="EutC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39330">
        <property type="entry name" value="PTHR39330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05985">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018982">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="2 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="25064" checksum="B0A0A65E631D4337" modified="2011-04-05" version="1">MSSLVRGLRGLTPARVSLGTAGRSLATEEVLRFQLDHARARDAVRAELGVGGFARRLRDEVGVEVVELRSRARDRAEYLRHPELGRALGTTEGLVRGDWDLGIVVCDGLSSLAVERNVVPLLSALLPMLEGWSVGPVAVVAQGRVAVGDEVGERMGARCCLVLIGERPGLSAADSLGAYLTWGPRVGRTDAERNCLSNIRVGGLDVDGAAGRLMGLLRGARARGGSGVGLKEGVLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U2</accession>
    <name>E8X4U2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="5" type="ordered locus">AciX9_3577</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581892.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3577"/>
    <dbReference type="EnsemblBacteria" id="ADW70581">
        <property type="protein sequence ID" value="ADW70581"/>
        <property type="gene ID" value="AciX9_3577"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3577"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_0_0"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="22015" checksum="E0A5539B7F60009E" modified="2011-04-05" version="1">MNRLGILLSGRGSNFLAIHRAIQDGRLPGTEIAVVLSNKSAAPGLQAARDLNIPAHHIPTAGLPPEERDLPYIAALREAKVDLVCLAGYMRIISPAFVDAFRDRILNVHPSLLPAFPGLESQTQALEFGAKIAGCTVHFVDEKMDHGVIILQKAITIEDSDTPDTLSARILAEEHQAYPEAIAHVLSGQYTAQNRRYIKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z4</accession>
    <name>E8X4Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578515.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67186">
        <property type="protein sequence ID" value="ADW67186"/>
        <property type="gene ID" value="AciX9_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0099"/>
    <dbReference type="eggNOG" id="ENOG5033MH5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903753_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="15084" checksum="470E5E2344C6246B" modified="2011-04-05" version="1">MNSEEQQLSERIREAIAAIDRQTRAGMVPDIAGASVDTEAVQVVGREQDFLDLQKMKEQIKDMQSARSQRERYARWVFALVASWILALFIILIAQGACPAWRPFSDKVLITLVTSMTINLIGTLVIVLKYIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X590</accession>
    <name>E8X590_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1292</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579677.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68354">
        <property type="protein sequence ID" value="ADW68354"/>
        <property type="gene ID" value="AciX9_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1292"/>
    <dbReference type="eggNOG" id="ENOG5033HJW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134923_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="19255" checksum="EDAF7B5009B48ED2" modified="2011-04-05" version="1">MSSYTTTLIERFAGRGVLIDTNLLLLYAIGKYDPDILSRESFDRVATYSIEDYQLLGNLISLFRQKVTTPYVLAEVSNWIGYLARAQEVECLRGLIDSLDTFTELQVDSFELGKDASFPFLGLTDMALAAYANDYLIVTDDARLIFHLNELGREALNINHLRQEIWLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D8</accession>
    <name>E8X5D8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPW_gp25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580801.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2450"/>
    <dbReference type="EnsemblBacteria" id="ADW69485">
        <property type="protein sequence ID" value="ADW69485"/>
        <property type="gene ID" value="AciX9_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2450"/>
    <dbReference type="eggNOG" id="COG3628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133204_0_2_0"/>
    <dbReference type="OMA" id="DIAFPFR"/>
    <dbReference type="OrthoDB" id="1791538at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13159" checksum="E560329AC5637761" modified="2011-04-05" version="1">MNVAFPYRFDSRHRTAVATDADHIRDLIEQVLFTAPGERVNQPEFGCGLLQAVFGPNSPELASAAQFLVQGALQQNLGDIINLTAVEVTAVDSTLTVTVEYILRTTQEQVVTQISRGGQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R3</accession>
    <name>E8X5R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion-associated protein, ImpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572709.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70797">
        <property type="protein sequence ID" value="ADW70797"/>
        <property type="gene ID" value="AciX9_4001"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4001"/>
    <dbReference type="HOGENOM" id="CLU_031288_0_0_0"/>
    <dbReference type="OMA" id="CGRGWLD"/>
    <dbReference type="OrthoDB" id="1255529at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010657">
        <property type="entry name" value="ImpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017739">
        <property type="entry name" value="T6SS-assoc_VCA0119"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017740">
        <property type="entry name" value="TssA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37951">
        <property type="entry name" value="PTHR37951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06812">
        <property type="entry name" value="ImpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16989">
        <property type="entry name" value="T6SS_VasJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03363">
        <property type="entry name" value="VI_chp_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ImpA_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="619" mass="67253" checksum="5349FCC94ED95C1B" modified="2011-04-05" version="1">MPLREDLLEPIAGANPSGTNLYYDKVFDQIKEARIEDDDSGSAGAWERTPKKADHVLVIKLASETLAKRTKDLRLAGWLIESHLKREGIALLPGCLDLILKLQDQFWDTVFPEIDDDGDLGLRVTAIEAPVNRIASFVKGLPILKNGFGQSKYVESRKVGYEKAADTKEKREARQDAINQGQVTAEDFDIAFAATPKTFFVATEEALTASLLLIDEMGVFQEDKYGDDYPAMNKLVTSLEEVKQAVSGLLNERRKTEPDIEIAPEPEPEPEPEPVVVVAAPIAVAVESQAAPAAVPVVQTAPLKAAGFGGVPTTPEQAHTAVMEGALFLHGQAPQSPVPYLVCSGLRFGEMRAQGAVYELNFAVAPPTETRQALKRLASESNWNDLLTLGLKTLGEPCARTWLDLQRYLWRGATGLGANALAAAIVSTVRGVLIDLPEIRGWSLDDDTPAANAETQQWIDAAILPPAPVIEEEKPTVEAPVVAAPPPMGAGPEQMKGPDIYEQATILLKSGKTGEAITLLVRDAELQPSGRTRFQRRVQVAQLCLVADQGAIAYPVLVELSKEIERRGLETWETGEMLAHPLGLLLKCLDKRGSPAEEKEVVFERLCRLDPQAALGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U0</accession>
    <name>E8X5U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4028</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572736.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70824">
        <property type="protein sequence ID" value="ADW70824"/>
        <property type="gene ID" value="AciX9_4028"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4028"/>
    <dbReference type="HOGENOM" id="CLU_085355_0_0_0"/>
    <dbReference type="OMA" id="IHNHGPE"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234425" evidence="1">
        <location>
            <begin position="32"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="144"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="31593" checksum="510693C321057D94" modified="2011-04-05" version="1">MSSTSTRRNFLASSALAAVTCAVAPTLPAMAEPAVHDGTPSPIKLGLASYTFRNFTRAQMIGYMKQLNVSDLNVKDIKDHLPTDPTLEAAAVSDYTAAGIKLHAAGAIYFPKDEDDDIRAKFEYCKRAGIKVIVAGDPTPASLPRVEKFVKEYDIKLAIHNHGPEDKLWQSPLDILKLIKNMDPRIGCCIDVGHTERAGTDPIKAIHEVGPRLFNMHIKDLTDLGVKESQVAVGDGKIPIRGIFEALIATKYQGFVDLEYEVHGDDPMPGVIGSFAYMRGALAGMGYSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W2</accession>
    <name>E8X5W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4057</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70846">
        <property type="protein sequence ID" value="ADW70846"/>
        <property type="gene ID" value="AciX9_4057"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4057"/>
    <dbReference type="HOGENOM" id="CLU_220014_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="38" mass="4136" checksum="F3F944D38376DB41" modified="2011-04-05" version="1">MPSKMNGSETVKAILTDIQFWIPALVLLGGVVMLVILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X7</accession>
    <name>E8X5X7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4078</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70861">
        <property type="protein sequence ID" value="ADW70861"/>
        <property type="gene ID" value="AciX9_4078"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4078"/>
    <dbReference type="HOGENOM" id="CLU_013951_0_0_0"/>
    <dbReference type="OrthoDB" id="517836at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="2">
        <location>
            <begin position="517"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="847" mass="94810" checksum="8F1A8AC12E79CEA8" modified="2011-04-05" version="1">MSAALPGVEHGVDPVERYESAPRPARTWEESSTDGVNPREHWSGLMHSLETLGTEELRRRWALAERRIRENGVTYNIYGDPEGMNRPWQTDLVPLLIAEDEWRFLEAGIIQRAELLSRLLEDLYGPQNLITEGHFPAALLYGNPAFLRPMVGVTVPPHSHLHMLAVDLARSPDGQWWVLADRTQAPSGSGYALENRTIVSDVLPDLFRDSNVQRLAPFFRAQREALLAMSPRQPARVVLLTPGPLNETYFEQSFLAKYLGLTLVVGSDLTVRERCVYLKTVTGLEQVDVILRRVDDGFCDPLELRGDSLLGVSGLVDAVVAGNVAVANALGSGLIESAAIMPFLPGLASHLLGEEIKLPSVATWWCGQEPALDWVLDHLDRVVVKPAFPSRGMEPVFGAELPEGQRAELIERLRKAPHEYVAQERVALSTAPVWEDDRLLPRSMVLRTYVLRTPKGWVAMPGGLVRVSEADGAVVSMQRGGHSKDAWVLSHKPVDTFSMLRPATEPLDLRRASPVVPSGVADNTFWLGRSVERAENIARILRSMVPRVRLGETTELESLLRLHSSLGSRQSKLPKRKQPTFVALEKEMRSMLTDMKRWDSLPCTLAEIARIGGNVRERLSADMMLLIGQLRTAMQSEQKLTLPEYSVKLTECLELLSAFSGMERENLIRGSGWLFMSLGRRLERAIYLTRQLRLITRPLAAGNWSYLEYLLEVADSSVTYRTRYYTTLQPLAVLDVLMLDGSNPRSLEFQLDHLVELYEKLPRFDPADLLTLTRALDRLRSVDLQSIVYPTPGPNGSAAGKPLRPDPALRRLDLSLAELEELLPSWSNNLSSRYFSHARTLPISMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X606</accession>
    <name>E8X606_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4110</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572802.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70890">
        <property type="protein sequence ID" value="ADW70890"/>
        <property type="gene ID" value="AciX9_4110"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4110"/>
    <dbReference type="HOGENOM" id="CLU_412662_0_0_0"/>
    <dbReference type="OMA" id="FFIIGRY"/>
    <dbReference type="OrthoDB" id="871957at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233724" evidence="3">
        <location>
            <begin position="41"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="714" mass="75905" checksum="15D3B5F919D1297E" modified="2011-04-05" version="1">MGLSAVSTKPASRTLRRVLLTATTAALTCAAALLAQASTAAAPTPQTPAPAPQTAAPTTKITTPTTPTVPLQVPPANFDLEARSNQVLAHLSAVIRYYRTAVTPIQKVGEPTDALYREEAVSDAKLIAAYAFQSGIAEAKLLAAYQKQQPDTPNAAPSDGKQPPVGEAQKLQTTLIGVNKRTEDLKTQQKTLEDQLQSAKSAEIPTLRAQIEQVQGALQLNVAMSDALSKIVSMSDTQGQAGLAGDIEQLSRTAPELTDPKSKVVPAPLENLSAARSAGVSSQATVLFQLLSTRRDIDQWTQETDALHAQALALRTPVTDTLRGTIRKGQDLSQQAADGTIAPPPAAPSAIPAVKLTAAQAQAAQAAAAAAGLAQLKQTRATFDSITATFKVLSDAAVPLSQEIITLEQSRANLVAWRLAVDSEYHSVMRSLLLRILVIAIALGALFIIGEVWRRATSRYVHDLRRRRQFLGMRRIVIGFLSGLVLILGFVNQFNSLATFAGFITAGIAVGLQTILLSVAAYFFIIGRYGVRVGDRITVAGVTGDVIEVGLVRFYVMELAGNGLELQTTGRVAVFSNAILFQAGTPLYKQMPGTDYAWHELTVKLQDSADYRHAAKVLLGGVEKIYAGYKQLIEQQHRNVQAGVDAAIDAPTVESRVLLVDGGLQLLVRFPVEIRDASLVTQQVSEALIALIQGDEAVKQAVAAAPVIKAAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X682</accession>
    <name>E8X682_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572878.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70966">
        <property type="protein sequence ID" value="ADW70966"/>
        <property type="gene ID" value="AciX9_4187"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4187"/>
    <dbReference type="HOGENOM" id="CLU_1183701_0_0_0"/>
    <dbReference type="OrthoDB" id="1469919at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="26208" checksum="185E575104F48945" modified="2011-04-05" version="1">MALDSTTIAPPATLDKRKLLLRDSITFLTLALIALVLYGVTTLLFHSFESHREDLGKRWSQRGEQAIQQGRPAEAIIDLRAALTYAPDDEPYQLLLAQALANDGRTDEATAYYEAFHEAHPGDGNINLQLARLARKKGTAHEAIDFYRASIFGAWQGDAITRRREVRLELAAYLIDQHELPLARAELLIAAGNTPDTAASDLTLAEMFEQSGDPDNAYTYYRKYGARPEPRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X689</accession>
    <name>E8X689_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4194</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572885.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70973">
        <property type="protein sequence ID" value="ADW70973"/>
        <property type="gene ID" value="AciX9_4194"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4194"/>
    <dbReference type="HOGENOM" id="CLU_037612_5_5_0"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009744">
        <property type="entry name" value="VirC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07015">
        <property type="entry name" value="VirC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="25476" checksum="794B37F49B372167" modified="2011-04-05" version="1">MVIAVSNPKGGSGKSTSTLILATHLAHLGASVCIIDADPNRPIQDWKIKGKSNSTLTVIADVNESNFFDVLDAQVPHFQFVFIDLEGTASFLVSRAISAAGLVIVPVQASAIDVRQASKAIKIVQDEEKAVRRFDSTRSILFRILMTRTPAPGAPVSASQKELEQDLLAAGIPRFQTTLAERQAFKAMFNLRLTLQELVGDKRAGNLAAAYENADQLATELVALIAQQPEAAKEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C5</accession>
    <name>E8X6C5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4233</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572921.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71009">
        <property type="protein sequence ID" value="ADW71009"/>
        <property type="gene ID" value="AciX9_4233"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4233"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="WHLSEIT"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="155"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1162" mass="123994" checksum="C5531781C49708F5" modified="2011-04-05" version="1">MKQIVSNVRQHRFGSVKLQAAGLTLGLGSLLSTPILLAGSATALAQNTNATIRGQVLDPAGALVPNATVVIVEKNTGVTAFRGPTDSAGVFVAPQVIPGTYTITVTATGLKAAVIDNLIASVAQVANVDVNMQIGATSEVVTVQAKGEQLATSTSDISTAISPEDVQNIPVVGRTVEYLFALVPGVTHGGSGDTPSTSAISFNGSRSLNSEILLNGVSMIVASTGAPVALPSPDGIDQVRIFTSNAPAEYGRTSGGVVTANSISGTNVYHGNAYFLIQNEALNANSYFNKLTLVNGAVIPRARDRFFQAGGSLGGPVWIPHLYDGHNKTFFFVNYDRTISNAPTLLSLTVPTAAQRTGDLSNALATTDALGRARTAQRIFQPTGVNSPAFTNNQISPIDPAAARILALLPLPNTPGTYDATNNRYTGNWTSQQAPVNDTLRLVARLNQQMTTADRISLNLYRYNSSAPNPVYYNNPLLNSTFDCTCSNAWLPSIDYTRVWSPSLVMDLNLGYFRNVVIRNPPGAGLNAKQQTGIASLPLDQMPELTSPGFSNIGSDTNTDQLNTTNTFTPFGSVTKTVGPHTLKFGASLRKNQFNSFNPSGNPEGTLAFSGTLTNHGTTGNANTGLADFLLGKITTGNYQLPMPETGRRNYSLGVFAQDDWRATPRLTINAGLRYEYESPMTVSKNIYTRFDPNSGQLLAAGLNASNSLNINTPKIDISPRFGLAFSVDDKTVIRAAFGTFYGTVFQNLGGQVAFPGYDVVDSYNSLGTAVGQPFSLSQGFPLNATRDLKNPFAALVGASASNPFTISGVSFNQLNHLSLVQQWNLGVQRRLPLSLILEVNYVGNHALHLPYVIPVNIVPFGLSDAVTQTNTTTATQNAKPFPTLGSFTVTNDVGNSNYNGLQVTLRRQFNTQLAILSNYTFAKSLDDGSSIFANGVPNGTANPQYIADPALRRQDYAVSNFDTKHTLNIAVVYTTPGPKWLHNIVISPIFYGHTGLPLNITQTNEVPNASQQRPNGDSSRLKLAHTTLNGSALQYLDNPSIDKTAFPLTPTGPIYSTINGVRTRIVETGLGNVPRDSIRAPGEVEFDASVSRSFTVYKAVKFQFRVDAFNVLNHTNLSPPSTSLTVTAVGTAASFVNSSTFGEITAARPTRRLQALARFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D0</accession>
    <name>E8X6D0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4238</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572926.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71014">
        <property type="protein sequence ID" value="ADW71014"/>
        <property type="gene ID" value="AciX9_4238"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4238"/>
    <dbReference type="HOGENOM" id="CLU_371636_0_0_0"/>
    <dbReference type="OMA" id="GHEMGHR"/>
    <dbReference type="OrthoDB" id="2104981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="748" mass="80409" checksum="6CFD3EF67E8340F9" modified="2011-04-05" version="1">MSFGRGRLLAQAAVLMVPAFGLAQYRQEPGHSLGTVTTQGNLIVLTLDEGVLGKDHLFNLAHRTIRFTPDGVRYRAENVAEQWDADFGPELHGNEATLTKFAFPFSGKSWSSISVGMTGSMTFSEAPLAPEGGRRGGGIEIERFAELSQAAAGLINTVPAISVFFKPRMSGTRYVKELADRVVLTWSLTEPVGGVQDMTWTPTVNKFQAVLWKDGRINLTYDEVHAQDAIVGIYPMVAGGFEKEIGSVAGEDKSGIAPNLDVMKVKLSAVDGLLLKATLETKGPVPAANDPAAMGVTYRVCLDKKKPTGDCAVGGQSDAVWTVQAGGGRGGRREGATPRYVASGMGIAPGVKIDGNTISLQGTLPAGYKSGDTVYVSAGVQTAGKTVDQVAAHEVKLVGLGSPAVDLATVKKGDGPFAVAYESFHYMRPPRANDLTCSVIKALGDKYDMLAYYSDFRIDNPEAGTSSTGPLGGGPAGGEVTGIGAKQRNLASYCSQGRFQWQFIQPVYVGANQMQEYPPDGLKEADTHNLVSYSHQLEERTSNGKIPPYDYAMSQIGHEMGHRWSAFVSAKVNGETIQLGPTHWAKGLQAPVAFPYQRPTEASAMGGGVWQDNFDGTFTQLDDDYYVPATGWSYLDLYLMGMISPAEVPEFFILRNMVAAGKDANDHAIYKADRTKVTVQDVIAVEGPRLPAVDAAQKGFNTGMVVVVEHGKMPSPLLVERVNGIRERWMDYWTTTTGYRSTMTADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E5</accession>
    <name>E8X6E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572941.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71029">
        <property type="protein sequence ID" value="ADW71029"/>
        <property type="gene ID" value="AciX9_4253"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4253"/>
    <dbReference type="HOGENOM" id="CLU_551843_0_0_0"/>
    <dbReference type="OMA" id="DGIMWGS"/>
    <dbReference type="OrthoDB" id="314334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230277" evidence="1">
        <location>
            <begin position="39"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="514" mass="56336" checksum="EF3DFF6B365F00FA" modified="2011-04-05" version="1">MEDSTQSATDTTRRRFLKQIAAAPALALASGGSALSQAATKPAASPATKTNKFVAIQIGGRSFVDEGVDQCLDTLQQVGGVNVVMATVFTYGSGLAGRQVHGEPLPDHGIKEYDRVQGGSFTRVHPEFYAASPIKDIRAPELGDFDILADVIPKTKAKGMQTYALFEENYNPRLIPNFAAIAEVDLYGRVGGTTCFNNPNARAFLSSMVSDWVTNNDIDGLMWESERQGPLNNTIGASFNKIFPRRSSTANCFCEHCIRKAKEVGIDGNRARQGYIALDHWVIRTQAGPATSDGSFVGLWRLFLEFPEIFAWERFWYTSQEEMYALIYGTAKAIKPRLQVGWHIMHVVTMSPFYSADTNYARLVPFSDYLKPCPYNNCAGPRLAQYIRNVQSTIFRDLTPERVLDMHYAFFGYTGEPTLDKLPTSGLSGDTVGIETKRAIADVQGAIPIYPGIDIDVPTELNEKRTQPSDVRAATLSALKAGAPGVVLSRKYAEMKLTNIAGAKQALHDFGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H0</accession>
    <name>E8X6H0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71054">
        <property type="protein sequence ID" value="ADW71054"/>
        <property type="gene ID" value="AciX9_4285"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4285"/>
    <dbReference type="HOGENOM" id="CLU_3062064_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="5821" checksum="1FBA01798B118C70" modified="2011-04-05" version="1">MNIGMEFCNQPAIKTMLTGGTIAWAWAFALAGQPMLNFLKVVHLDKRSSAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H6</accession>
    <name>E8X6H6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">AciX9_4292</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572970.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71060">
        <property type="protein sequence ID" value="ADW71060"/>
        <property type="gene ID" value="AciX9_4292"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4292"/>
    <dbReference type="HOGENOM" id="CLU_118482_0_2_0"/>
    <dbReference type="OMA" id="TWMEVLV"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="14094" checksum="849192EB1D8CCC56" modified="2011-04-05" version="1">MVAVPSLYDTNILIDYLNGLEAARTELESDVAQDRAISAITWMEVMVGVPQSLEAPVRRFLSTFKHLPVTRAVSEEAFTIRRQSRVKLPDAIMLATARAHNRVLVTRNTRDFPVQTIGFHVPYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K0</accession>
    <name>E8X6K0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71150">
        <property type="protein sequence ID" value="ADW71150"/>
        <property type="gene ID" value="AciX9_3868"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3868"/>
    <dbReference type="HOGENOM" id="CLU_090960_0_0_0"/>
    <dbReference type="OMA" id="FEREYET"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234247" evidence="1">
        <location>
            <begin position="34"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="25003" checksum="5966E4B1C65CEBCE" modified="2011-04-05" version="1">MPRTRPHTPRRYAKLAACSALVFLNGCGSGIHASGPALLATTAPTGVLRLVTIGNSITWHSPENDVSWSGDWGMAASNINADYAHLTATSLSLPLVRVNVAALESDPTTVDALTAQTAALITPGSAVVVELGDNAKPGSNGRANFQAAYHQLLDAVATGKSLACTSTYWGESSIDAIIQAECILHHGSYIYIGDIYGSPINTDSSTNTFSNPFVIMHPHDWGMNAIAVRVQQHILQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L9</accession>
    <name>E8X6L9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS204/IS1001/IS1096/IS1165 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3889</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71169">
        <property type="protein sequence ID" value="ADW71169"/>
        <property type="gene ID" value="AciX9_3889"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3889"/>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="130"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="50382" checksum="364C826CA1733FFB" modified="2011-04-05" version="1">MRLKSCRACVPCPACGTCARKVHSRYKRRLADLLWDGVPVVIQLQTRRFFFVEPGCRRKIFTEPLPGTVARYGRRSCRLGEALRWLTLALGGRAGARLAERLGLVASRSTLLRELHHRRPVPPVEAPRVLGIDDWAWRKGHRYGTILCDLETRKVVDLLPDRDANSVAACLQQHPGTEIISRDGGGIYAEAARRAAPQAVQVADRWHLLRNLSEALCRAIAQHHRLFLQAARANRLEGPAPASPPDAPWSQRELLVQQANRQRRYERWDQVRELFLKTSASDQELARQLGIDHRTVKKFRTAEVYPEAKPRVRESIVDHHASYLDRRLKEGCRSSTRLWHELREQAFQGQRNSVSYWLQQRRSYRTRAGRPPERPALRASPRQVVWLILKAAPAAKDMLEETPCAKHLDCRGTRVTSKARSTASSSSNDKCTAEQASTSCACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M0</accession>
    <name>E8X6M0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3892</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71170">
        <property type="protein sequence ID" value="ADW71170"/>
        <property type="gene ID" value="AciX9_3892"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3892"/>
    <dbReference type="HOGENOM" id="CLU_948969_0_0_0"/>
    <dbReference type="OMA" id="AHQDWRT"/>
    <dbReference type="OrthoDB" id="1070946at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="36905" checksum="E54CA5156D752B6C" modified="2011-04-05" version="1">MVRFIGTETNSPEGDLMKPFHEIHSNDLNSGQLQRELDSRGYVLIRKLLPAEDVETLLREIVQNLSANDWFLPNHSPMERVADPNAACGEPDPLFKLIYEQIFNLEALHRFAHHPRLREVMHSIVGSQLLVHPKPIARLIFPNWDRFVVHAHQDHLAIGGDPECFTAWIPLHDCPAELGPLQILDGSHRFGLQEADPSTGEISKDTARGGDWVGGQINAGDVLIFHGLTVHSASPNTSEQLRVSVDCRFQDYTRTFNPANAVFPGSNGKSWETTYANWRSEELKYFWRQIPLTFKPSREELVELIETDDSQRMRTRYARVLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M3</accession>
    <name>E8X6M3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3895</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71173">
        <property type="protein sequence ID" value="ADW71173"/>
        <property type="gene ID" value="AciX9_3895"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3895"/>
    <dbReference type="HOGENOM" id="CLU_823687_0_0_0"/>
    <dbReference type="OMA" id="HHAQGYW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="39081" checksum="AAD9506CC5462D01" modified="2011-04-05" version="1">MVLPILNTMTARSIQSAQRISVAAILFCAVRYGLAQDTPFLSGGVGFLTATNAGKTTYIPTIQPLLAAPIGPHLLIESRAALVESFSPAADGKYDHNHFIALTYLQGDYTVSSHLTVVGGSFLLPFGTYNERLTPIWISNFSDAPLNFNLGQMSSAIGTGGMLRGSAISRRKYSIDYAAFFSSRVGNQQFAATRASGGRASLYLPEKRLEIGFSYDRSLQGIHENFYGMHVWWEPKDTAFRLRSEFTRGHHAQGYWIEGDYRLQKLGGSDSWIGRIEPVIRMQQTFRRDTLVSDGLPLVNTERIDLGLDYNLPHNTRILTSYARQFSAAGNENVWETGIVYRFLFPAWKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M9</accession>
    <name>E8X6M9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cys/Met metabolism pyridoxal-phosphate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3903</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582197.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71179">
        <property type="protein sequence ID" value="ADW71179"/>
        <property type="gene ID" value="AciX9_3903"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3903"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_0"/>
    <dbReference type="OMA" id="SKTRMIY"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="379" mass="40783" checksum="FE40DDD141AB8C5D" modified="2011-04-05" version="1">MKFATKLVHYDVSPGDPFHPMATPIYQTATFEQDFGDSFGPYDYSRSGNPTRRVLEDQLARLENGIRAFCFSSGMAAIATVTRLLKPGDEILADWDLYGGATRLFQQLKDHSGVAVRYVDASNPEILASQISPATRLVYVESPTNPLLRVIDLQASARIAHENGLHLCVDNSTMSPYLQNPLELGADIVIHSATKFLGGHSDVTGGAVVVKDEALAAQIYSVQNAEGTALGPFDCFLLLRGLKTLKLRMDAQQSSAGQIAAQLSEHPKVSRVYYPGLPDHPSSATQKLQARGAGSVISFQAGSPQAAKAIAENLRLFAIAVSFGSVNSTIGIPIKMSHASTPVDLQSSRAIPSDLIRMSIGIEDCGELMQDLDDVLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X4</accession>
    <name>E8X6X4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582105.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="acism-e8x6x4">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71083">
        <property type="protein sequence ID" value="ADW71083"/>
        <property type="gene ID" value="AciX9_3797"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3797"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_0"/>
    <dbReference type="OMA" id="CITHHYS"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233755" evidence="2">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="34066" checksum="0203DDF3E6E49C77" modified="2011-04-05" version="1">MFKLFFVSFALTASLHAQAPVTGVLHTPDVDLAYEVYGSPSSATPVFAVNGGPGLSHQYMLQNDVWPRLSAHRQIIMYDQRGTGKSQHVREGASQTMAAQVADLEAIRAHLNLPRIDLVGDSYGGLVSIAYTAAHPDRVERLVLSDSAAPNPKKMVHLLPDVFPDVEERSAAEQAKLGDTPEASNANLIAHFRMIFYSPELRDEYLNKFLAKDKTLGSTPATSKAVWAANQGGDLTAMLPAFHCPTLVVTGRYDMNVAPINAWLMHKAIPGARFEAFEKSGHLPSYEEPEKYVKVLDEFFNENASDKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X738</accession>
    <name>E8X738_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71272">
        <property type="protein sequence ID" value="ADW71272"/>
        <property type="gene ID" value="AciX9_4316"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4316"/>
    <dbReference type="HOGENOM" id="CLU_027402_34_1_0"/>
    <dbReference type="OMA" id="AEATFYV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10691" checksum="2BFDEFFF7D3AD3BB" modified="2011-04-05" version="1">MARGNKHTAEQIVNLLRQVEVGVANGKTLPQACKEAEIVEQTYYRWRREFGGLKVDQARRLRELEQENAKLKRLVANLSLEKLVLKDIAEGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X780</accession>
    <name>E8X780_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4362</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71314">
        <property type="protein sequence ID" value="ADW71314"/>
        <property type="gene ID" value="AciX9_4362"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4362"/>
    <dbReference type="HOGENOM" id="CLU_3168640_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5214" checksum="B712A2CCF87BC95A" modified="2011-04-05" version="1">MDSDVALKIVDVKEADRSRWTVFFSNGASILVTAKEWADLSPALFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A6</accession>
    <name>E8X7A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMP/dCMP deaminase zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4389</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573059.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71340">
        <property type="protein sequence ID" value="ADW71340"/>
        <property type="gene ID" value="AciX9_4389"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4389"/>
    <dbReference type="HOGENOM" id="CLU_025810_5_3_0"/>
    <dbReference type="OMA" id="CKERRSI"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="18279" checksum="FEED6B92E9F4C60E" modified="2011-04-05" version="1">MKDAKDLTFMAAALEQARIGQETPGGAQVGCVLVENGAIVCSSFNEGDLQFDPTAHAEMVGIRRLCKERRSISLKGVTVYCTLQPCGMCTMACLWAGVSRIVYGASRNDVNSVYFESRHFDTADFIDQAFRDDLEVKGGVLSDECATFYLKPEETAPIDPAHDVTSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J5</accession>
    <name>E8X7J5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4483</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71429">
        <property type="protein sequence ID" value="ADW71429"/>
        <property type="gene ID" value="AciX9_4483"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4483"/>
    <dbReference type="HOGENOM" id="CLU_1014758_0_0_0"/>
    <dbReference type="OMA" id="SRVALFW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="29990" checksum="F5E77482B840A942" modified="2011-04-05" version="1">MNEGVQVLNERTTGQRPPSFVQSMRSANVPRVDARYWSAITVASIFGCNLGDCLSFYAHWNHWIGLAPLAAIFALLLLGERRSTRTTQAWYWTVVIVLRAAATNLADLATHTFEWPYVRVIIGLIVLQMLVVWLVVPRPILPRGSSTGRPSTTGAYWFSLLTAGTLGTAIGDWSAEALHLGTGYATLALGAIFAMVLLIGRESRWTTKLAFWSAIVAVRAAGTTAGDWMAFREEPGLSNGLNLGLPFSTSLNCALYVGLLVLWRPHRGRNSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q9</accession>
    <name>E8X7Q9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4562</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573212.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4562"/>
    <dbReference type="EnsemblBacteria" id="ADW71493">
        <property type="protein sequence ID" value="ADW71493"/>
        <property type="gene ID" value="AciX9_4562"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4562"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_0"/>
    <dbReference type="OMA" id="RRNWIDA"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="32380" checksum="B1BAC81C59F03C8B" modified="2011-04-05" version="1">MKGIILAGGSGTRLHPVTQAISKQLLPVYDKPMIYYPLSALMLAGIRDILIISTPNDTPRFEQLLGDGARWGLNLQYAIQPSPDGLAQAFLVGKDFLAGEGCCLVLGDNIFYGHDFARSLREAAAQPYGATVFAYAVNDPERYGVVEFDASRRAISLEEKPLKPKSRYAVTGIYFYDPQVVEIAENLKPSPRGELEITDINRWYLERGELRTELLGRGIAWLDTGTHDSLLDASNFIQTLEHRQGLKVACPEEIAYRLGYIDADQLRTLAARFGKSTYGSYLTHLLEEAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S6</accession>
    <name>E8X7S6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4580</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573229.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71510">
        <property type="protein sequence ID" value="ADW71510"/>
        <property type="gene ID" value="AciX9_4580"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4580"/>
    <dbReference type="HOGENOM" id="CLU_1882829_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15270" checksum="7371F681EA13E970" modified="2011-04-05" version="1">MHITFLFERLFAGILGMSFLSSPSLGFSQYAASTAPKSNKLYIICSLVDDPHKTVYYSGVFRGVDPSLHAYEKSFSTHLEMSATNLIGTAKCSSFQDELAAKANMANLQENWRWIYKNSINTNWMYTPLSKYSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V7</accession>
    <name>E8X7V7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4611</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71541">
        <property type="protein sequence ID" value="ADW71541"/>
        <property type="gene ID" value="AciX9_4611"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4611"/>
    <dbReference type="HOGENOM" id="CLU_1292879_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23694" checksum="394F1A5EE1540B19" modified="2011-04-05" version="1">MGSFPSRASSHPARVQIFPAECGSKFASYDIGGQYGKLASFHPYRLVGLGYRRSIPRAHGVGSLSRRPESISFDKHVLPPNPRKLDQEAAHRRDQFMQNDGVGNHGLFSPFRPSSLASRSRDCRKHRLFGSFTSMTGVNVGECRKIQFISDPRISPVIIVPLRRDSLGLLPSEKLARWSDSIAPEHQELARGAHLRCQVWNVRGCLPCSSFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X3</accession>
    <name>E8X7X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4627</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71557">
        <property type="protein sequence ID" value="ADW71557"/>
        <property type="gene ID" value="AciX9_4627"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4627"/>
    <dbReference type="HOGENOM" id="CLU_005379_3_0_0"/>
    <dbReference type="OMA" id="NVIEIML"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="32584" checksum="C5B6857D79B66752" modified="2011-04-05" version="1">MVNGTRGVFADRAGKVEKIELSDPYTNERLTAAIERVARVLGQDLTSQNPILNTRLPDGSRVAVVGPPASKDGPSLTIRKFNQWFTSDQLVASGSLPEKVRDFVVGLVMQRKNGIIAGGTGSGKTTLMKALLDHIPMTERLCVIEQPSELRIAHPNAVQWEAVDAIPGQVAVTPSELLAAALRHRPDRIIMGEIRNECGYDLLQAMNTGHGGTLSTIHASSALDALGRLANLALSARPNLNHSFMRSETASAIDFALYCERAPDGKRRVRELIHVRGYDQNTQTYDHDVIYSASDSSHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X812</accession>
    <name>E8X812_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4666</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71596">
        <property type="protein sequence ID" value="ADW71596"/>
        <property type="gene ID" value="AciX9_4666"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4666"/>
    <dbReference type="HOGENOM" id="CLU_692162_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234287" evidence="1">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="43682" checksum="87A29F5EA7F78DF3" modified="2011-04-05" version="1">MSVNRKTHLFALAILSSLSFAAYAQTALTQASNDKIDHWLRSGEPRMVAWGAAFAAKCGDRDALPLLASLAENYQSIPPQEYDARGNYIPRTPEQKQRLDSMEVVLDSVIQLHGRVPYEAITSALQDFPAQALTLFAGMPEPERSQRADVLYATRDKADQPYDWHHLAQQQMIHMAAAILALQPPPGFTATLLNETTVVLKVSVTDDEQKREDTFSGGVCGDSFGLKPAQGWPQPYTYVVEQHWNNQGSADGVLVPGEPSITTRRALSNSSCSTLPGFTSVQKLLLAEQEAGFLPEDRRTGTLQYDTLRYPGQASFVASLSSLVDRRKEPFRKLAATLAGKSFLSASEAATAMPMFAVEIDDQRKDQTQALQMPASLGSRTTVGPYKPESGWFLKQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD3</accession>
    <name>E8WVD3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1319</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579704.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1319"/>
    <dbReference type="EnsemblBacteria" id="ADW68381">
        <property type="protein sequence ID" value="ADW68381"/>
        <property type="gene ID" value="AciX9_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1319"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_6_2_0"/>
    <dbReference type="OMA" id="WYKGILV"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19042" checksum="51D16535709D6E43" modified="2011-04-05" version="1">MNTLKAYKSSPTLENSTWYKGILVSQLAGGSDTGGAFDLVESRMKQGTEPPPHIHDREDELFYILSGELKVFAQGKVLTVKAGESVFLPKKVPHAYLIQSEECHVLALMTPGGFMNAINNMNAPARAMQIPSDMETYATADLTDTMAVFMKYGLRMLSPDEIAEHLPGYPTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD4</accession>
    <name>E8WVD4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1320</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579705.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1320"/>
    <dbReference type="EnsemblBacteria" id="ADW68382">
        <property type="protein sequence ID" value="ADW68382"/>
        <property type="gene ID" value="AciX9_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1320"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_4_0"/>
    <dbReference type="OMA" id="GRLYMDS"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="169"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="30484" checksum="1E69A51DBA4C0BC8" modified="2011-04-05" version="1">MVEETGLQLQHLESFINPEPTYYMQHQQSLAKVLSPGRYQHGIIRNKLIDYSYAAGDLIVCNRGIDEFVRWDSDIRILKVDLPDEAFRAIANEAGADSVEIHSSTHFEDKRVAALIAAIQAEEEGGSLSGRLYMDSIAQALASALVQLRGNLKRSLPHYHCGLTPTQLARVKHLVYGRIDQEISLQEMATAAGLSASYFNQMFRRSTGQPAHQFVLNARVEHAKDLLKSPKLRMLDVAISCGFRTSQHFARVFRSICAVTPTEYRRALGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL8</accession>
    <name>E8WVL8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580862.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2515"/>
    <dbReference type="EnsemblBacteria" id="ADW69547">
        <property type="protein sequence ID" value="ADW69547"/>
        <property type="gene ID" value="AciX9_2515"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2515"/>
    <dbReference type="eggNOG" id="ENOG502ZUUW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2584810_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="9022" checksum="592E38C253E2ABD8" modified="2011-04-05" version="1">MYDQKKPPTSERSLPIPGRSGIEPLLDSNKAAAMLGVHPRTLQRMVLRGQIVGVQVGKLWRFRASAIDEWIENKEHKMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT4</accession>
    <name>E8WVT4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3692</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582002.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3692"/>
    <dbReference type="EnsemblBacteria" id="ADW70693">
        <property type="protein sequence ID" value="ADW70693"/>
        <property type="gene ID" value="AciX9_3692"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3692"/>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066233_0_0_0"/>
    <dbReference type="OMA" id="HNYYLLS"/>
    <dbReference type="OrthoDB" id="1265506at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230350" evidence="2">
        <location>
            <begin position="25"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="37900" checksum="8A15BADACDF5F188" modified="2011-04-05" version="1">MHLRPLILATILPALLLTSAPAQEAPPQDTPTLRLGSNLVFVPAQVQTKKGEMIYGLTPQQFTLEDNGVPQKFRVDEDTDARGLSLVVVVQCSREAFAQFNRMKGLDAMVDDLTGGAPRQVAVVSYGSEPELIGDFTPDPDKLNHNLAQLEPCEDGGNVTLDAVAFANKLFDQDPKTSALTQTRRAILLIGETRDHGSKVKPETVIADLGRSNTVVDSVSFNPGKTTIIDSLIHGQFGPGPFGLLVMAVEAVRRNVPHTLASLTGGEYTNFSTQKGFDAGIHKLANHIHNYYLLSFQPVGPAGAPLTPGLHRLTVKVPDYPDAQIRSRLTYYAGEAPPPEVPDKPEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT8</accession>
    <name>E8WVT8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative xanthine dehydrogenase, iron-sulfur binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3696</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582006.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3696"/>
    <dbReference type="EnsemblBacteria" id="ADW70697">
        <property type="protein sequence ID" value="ADW70697"/>
        <property type="gene ID" value="AciX9_3696"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3696"/>
    <dbReference type="eggNOG" id="ENOG50337D5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2787927_0_0_0"/>
    <dbReference type="OMA" id="HDGQCGL"/>
    <dbReference type="OrthoDB" id="1979408at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7122" checksum="D06131A9CE55118E" modified="2011-04-05" version="1">MQTVHDGQCGLCTHFGEAHEKTTVLVSILSSKSADATLLDSCGLPKNAALHLKVTPLSGCDGFQPAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY8</accession>
    <name>E8WVY8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="13">ACCase subunit beta</shortName>
            <shortName evidence="13">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="13">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">accD</name>
        <name evidence="15" type="ordered locus">AciX9_3747</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582055.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3747"/>
    <dbReference type="EnsemblBacteria" id="ADW70747">
        <property type="protein sequence ID" value="ADW70747"/>
        <property type="gene ID" value="AciX9_3747"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3747"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_1_0_0"/>
    <dbReference type="OMA" id="PEGLWIK"/>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="14">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW70747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="31645" checksum="10A32711BFCE41D5" modified="2011-04-05" version="1">MSWFKREDHKIVNDETKTVRTEGLWTKCGSCGTPLFKPDLAANLQVCPKCGYHFRFDARSRVENLLEPGYELVDLELRSTDPLNFTDLKPYKRRLAEAQKKTGLNDAIVNAIGQLGPHNVVLSVMEYAFIGGSMGAVVGETIARAVDRSLATRHPLIIVSASGGARMMEGIASLMQLAKISAGLARMDDAKIPYISLMTDPTTGGVTASFAMLGDLNIAEPGALIGFAGPRVIEQTIRQKLPEGFQRSEFLLEHGFLDAVIERKNLKSYLTDTLSWMTNQPATEKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW03</accession>
    <name>E8WW03_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0235"/>
    <dbReference type="EnsemblBacteria" id="ADW67309">
        <property type="protein sequence ID" value="ADW67309"/>
        <property type="gene ID" value="AciX9_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0235"/>
    <dbReference type="HOGENOM" id="CLU_2355769_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="11044" checksum="95AC040CF8BF66EC" modified="2011-04-05" version="1">MKILLRKLRWIDLGLAVLLATISVPFIFRSVMNHRMELYVRIYPHDGQDSLGAFFDALTASAFSWIGIIILLLGLRWLYVTLRPENLPLQTDISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW04</accession>
    <name>E8WW04_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0236</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578638.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0236"/>
    <dbReference type="EnsemblBacteria" id="ADW67310">
        <property type="protein sequence ID" value="ADW67310"/>
        <property type="gene ID" value="AciX9_0236"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0236"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_0"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="6">
        <location>
            <begin position="7"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="35688" checksum="FE48C0D53BA912CE" modified="2011-04-05" version="1">MLKPAFLFPGQGSQTVGMGRELYDNFPSAKAVFKEADEVLGFHLSHLIFEGPAETLQLTEHTQPAILTVSVAALRVLTESLQITPIAAAGHSLGEYSAQVAAGSITFADAVRTVRARGRFMQQAVPPGAGSMAAILGLSAEQVNDLCAQASEDASAPSPIDTTPSESATPRAEAARSIVSPANLNSPEQIVISGATAAVERAVELAKTAGAKKTVILKVSAPFHCGLMQPAQDQLASVLEAIDFADPAFPVACNVDARLLTRRADVRDCLIRQVTGSVRWVECLQLLVAQEPTHLIEIGPGKVLTGLTRQILGRNVETPISLNIEDQASLDKTLAALAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW18</accession>
    <name>E8WW18_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0250</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578652.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0250"/>
    <dbReference type="EnsemblBacteria" id="ADW67324">
        <property type="protein sequence ID" value="ADW67324"/>
        <property type="gene ID" value="AciX9_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0250"/>
    <dbReference type="HOGENOM" id="CLU_2409150_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10544" checksum="50916E42A1FD5BDD" modified="2011-04-05" version="1">MGTALAQLDEEILVREKIAELTLPDGVKFKRIEQMNDWTGDPSLTIYFGVSKRRPTSPKSIRELTVMTKTLRKAILDLGLGKFPFFRFEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW23</accession>
    <name>E8WW23_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578657.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0255"/>
    <dbReference type="EnsemblBacteria" id="ADW67329">
        <property type="protein sequence ID" value="ADW67329"/>
        <property type="gene ID" value="AciX9_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0255"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106747_0_0_0"/>
    <dbReference type="OMA" id="CAHAHPI"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233421" description="Thioredoxin-like_fold domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="46"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="25060" checksum="9824395225884C6E" modified="2011-04-05" version="1">MLLRKRVVAGLFALALSTPLMHAQFSGQSPRDNFRDTSILRPPAGSKVAIIVFEDLGCPACAKAHPYEQEVQKSTGATLVRYDFPLEGHIWTFDGAVAARYIQDKINPKLADQFRSDVFASQMQISNREDLHAYTDKWLKAHGQNPPFVMDPGGKLAAEVKADYDLGRRLNVEYTPTIVVVTKDHYQVISGTASLNFDPGNLQRATEAAVAQTKSAPAHAAAAKKTSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW24</accession>
    <name>E8WW24_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0256</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578658.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67330">
        <property type="protein sequence ID" value="ADW67330"/>
        <property type="gene ID" value="AciX9_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0256"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120900_0_0_0"/>
    <dbReference type="OMA" id="AECDKAY"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230361" evidence="1">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="19900" checksum="686199264860B4B6" modified="2011-04-05" version="1">MNRTLLALTSAAALALPALALPASAQQMSMPMPAPPVTTGPASEVLATYNRVKDNVIKAAEKMPAADYDYKPTADIRTYARVVNHVTEAQFHTCTTLNGGKFDPASVPTEAVGKDAIVAGLKASFAECDKAYGALTDANISEMLTQGKGKRSRIGMAWGNVSHDNEQYAELSTYLRLKNIAPPTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB7</accession>
    <name>E8WWB7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1447</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1447"/>
    <dbReference type="EnsemblBacteria" id="ADW68500">
        <property type="protein sequence ID" value="ADW68500"/>
        <property type="gene ID" value="AciX9_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1447"/>
    <dbReference type="HOGENOM" id="CLU_1419693_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="191" mass="21196" checksum="86645AE413AD69D2" modified="2011-04-05" version="1">MLLLHIDQQQRRTAGRGLCTRWNYEPARVPLPKQSVCKPAQLEVNMKTLISSKINTCGLGSQESSTLLLIEPRWPKVSRVSQQLEGSRFSVTVAHDAKDIYLMSGSIRIPCAVLSDELGAVALQASAEAVRWQWPRTSILILGTPGALEDHLYDDIVAHASGANVLIKRAESINEPAIDRRFDKRRESVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD0</accession>
    <name>E8WWD0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1460</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579833.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68513">
        <property type="protein sequence ID" value="ADW68513"/>
        <property type="gene ID" value="AciX9_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1460"/>
    <dbReference type="eggNOG" id="ENOG502ZK83">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025623_0_0_0"/>
    <dbReference type="OMA" id="DCERAIM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="120" mass="13254" checksum="874F59672DFAD0BD" modified="2011-04-05" version="1">MSERKWILVFGIDAMLLDTRTRLLESAGFQVARSASLEEVECQLNQRVISLLLLCHTLSSSDCERAIMTAHSINPKTVTLVLAAVTSPCIEKSDVFVHQMSGPQKLLETVEAVLNGKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH1</accession>
    <name>E8WWH1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2610</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2610"/>
    <dbReference type="EnsemblBacteria" id="ADW69635">
        <property type="protein sequence ID" value="ADW69635"/>
        <property type="gene ID" value="AciX9_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2610"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_0"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="30169" checksum="6E8D4782E750CADE" modified="2011-04-05" version="1">MGKLEFMLIDSHAHLDFYDDPTEILVRAEAAGVAQMLAIGIGDGPATMHRALDLARQHGHVFASAGIHPQEAHQATPEALEKLRALVADPKCIAVGEIGLDYYHLENPDIEVQQQAFVAQLAIAAEAGKPILIHCRTSDLATAEAKARFGPADAFADIMRLIAEHWTPAGIPGVMHCFSGSPEQAKQALAANFYLSFAGNVTYPKSLNIREAAAQAPADRYLVETDCPFLAPIPFRGKQNEPAYVTHTAEVVAELRGVGAALVAEQTTANFHTLFPSTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH2</accession>
    <name>E8WWH2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2611</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580951.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2611"/>
    <dbReference type="EnsemblBacteria" id="ADW69636">
        <property type="protein sequence ID" value="ADW69636"/>
        <property type="gene ID" value="AciX9_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2611"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911427_0_0_0"/>
    <dbReference type="OrthoDB" id="1925833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230376" evidence="9">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="32839" checksum="A0C0C327FD053EDD" modified="2011-04-05" version="1">MLCRKMKPAFAASLLLSLSFAALAQTPAPISDEPLTVPAVVYPSEAKRARVQGTVHLEIAVDPTGHVTSVHALDGPLLLRQAAVDAYTHATYKPLTDPKSGRPTPAVITTAVNFNLTELPPDTDLLVDRQFQPLQAQCQSYVDGGTKSEITTEALEACRQAVAMSHRFTPTAALESRATAVNDLVLVLLAQKNYPDAALVANEAVALVDTANHPHTPAVATAYITRCEARSLAKEYPGAAEDCAAAEETLTTLIADQSAPDQSKNDRTANYRTQLREVFELHAIVMDKQHQGGEARRLRNRASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH8</accession>
    <name>E8WWH8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2617</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580957.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2617"/>
    <dbReference type="EnsemblBacteria" id="ADW69642">
        <property type="protein sequence ID" value="ADW69642"/>
        <property type="gene ID" value="AciX9_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2617"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134960_0_0_0"/>
    <dbReference type="OMA" id="RCDLFIE"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17216" checksum="5428D23BB2396FE9" modified="2011-04-05" version="1">MDRDGIKTNETGVVYSGKFVGTEDELTAQIIGVFYKVFNELGFGFLESVYREAMAIALSEAGLSMAVEVPIAVTYHGKPVGSFRADIVVQGRVVLELKTAEQISKAHEAQLLHYLRASTMEIGLILNFGQLPKCRRVEFRNERKQNIAKSFSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW4</accession>
    <name>E8WWW4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1472</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579845.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1472"/>
    <dbReference type="EnsemblBacteria" id="ADW68525">
        <property type="protein sequence ID" value="ADW68525"/>
        <property type="gene ID" value="AciX9_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1472"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_1_0"/>
    <dbReference type="OMA" id="VCGFEHG"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21480" checksum="1DB105A612A60CA2" modified="2011-04-05" version="1">MAVELYLIRHGETEWSLSGAHTSRTDIPLTDHGRQRAEELRDYLKGTTFAKVLTSPMGRARETCKIAGYGEQAVIEEGLREWDYGESEGKTTKEMRAKYNKPDWSVWSDPIIGGEAVEHVGVRADGVIERALDGLTDGKVALFAHAHILRILAARWIGLPAVGGKLFGLGTGSVSTLGWERETRVISTWNRGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW5</accession>
    <name>E8WWW5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1473</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1473"/>
    <dbReference type="EnsemblBacteria" id="ADW68526">
        <property type="protein sequence ID" value="ADW68526"/>
        <property type="gene ID" value="AciX9_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1473"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="OMA" id="THQGAEW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="360" mass="39943" checksum="D7CC0812414A2D0C" modified="2011-04-05" version="1">MAAVAGGQRGSSLAFQRAEHLRRGINLSMWYAQSGDYSAGRLESFTTPDDFKLIKGLGFDHVRVSIDPDPLIAMPMSGALRPEAMARLDKTVAQLEAAGLNVVLDVHAGQDFVGKLANGEDGAANFFSFWSEFAKHFAGTDPEKVFFEVLNEPTMTDLYRWEGIQARAVARIRSVAPQHTILATASNYSGIDTLLALEPVRDENVIYTFHDYEPFWFTHQGANWGAQGWIFLRGVPYPATPQTIGKVLGQEQDERVRLWVQRFGYDHWDATRVGMEIAAAADWAQKRGVPLYCGEFGVYRTYADAKSRDTWISDMRTALESKHICWAMWDYQGDFGIVTKGSGGTMVDLGVVGALGLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX21</accession>
    <name>E8WX21_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fusaric acid resistance protein conserved region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579901.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1529"/>
    <dbReference type="EnsemblBacteria" id="ADW68582">
        <property type="protein sequence ID" value="ADW68582"/>
        <property type="gene ID" value="AciX9_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1529"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398887_0_0_0"/>
    <dbReference type="OMA" id="LWPVRTV"/>
    <dbReference type="OrthoDB" id="625405at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="698" mass="76363" checksum="6C1E5F96E4BF532A" modified="2011-04-05" version="1">MPVSALPRTPAAGLLLPRPTWAQALLQDLQPVPGRLHSTLRIVLASVIALLLLETLQMPFISLGLYFMFLVGRDSPAISFRTSFISLLQICFIIFLELSVVIVFDNDPMARLLSVVIVTFISAMILVATNYPALGPSGGLIFCTVISLWELHAPADRLVKTSLYLIGTFTISLGCAVAVEYIFAVRNPADQLQEQRRIRYHALAEMFQAFADGAPLAKRFEAATQVSRLASAGQSGMIQLYNDIVERNLDTGALPIAARPRITMLAQLMDISAAFGLQSYAVDDPELRERCARLAEDCHEIAPSFFRLPQKDLARREFETGSLLGRVENMIHTIMTMPMSGPEVNNRELVSLPSHKVPFFIPGAVRSPDSVAFALKISMCATFCYILYHALHWPGISTCVTTVLVTGLSSTGAIKQKLIFRVFGAIIGGLILGIGSTSLLFPHMDSITSLVVLTACVSFIAAWVAAGPKFNYIGLQIAFAFFSVAFTGFSAPTELAPARDRFMGILIALALMAFVFDLLWPVRTVTVMRRNLASVLRLGVDLLETLNSTQHRADALRHGDVLRDQVGKTLTGLRSANGSVAYEFGAELEQHIQSGDTIMAAAVTAVALFWNQLAVLHEGSDHSLFTDPGLRALRHHLANNMTAMAEAVVEKKAIRIEDVRQLLEPGLLADSRHSEYARNTVARYEELEALTANLSLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX94</accession>
    <name>E8WX94_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ordered locus">AciX9_2712</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581051.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2712"/>
    <dbReference type="EnsemblBacteria" id="ADW69736">
        <property type="protein sequence ID" value="ADW69736"/>
        <property type="gene ID" value="AciX9_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2712"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_0"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="313"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW69736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="48504" checksum="0C46B0724145D0F8" modified="2011-04-05" version="1">MELKNKRVLVVGLGRSGLSAAMFLRDRGARVTVSDTRSATALAKEIPALMEAGIMVESGGHGLLTFRRQDLIVVSPGVPLETPEIAQAAAFGTAVIGELELASRFLDGSVIAITGSNGKTTTTTLTGKIFADAALPTLVGGNIGLPVIDLIAESRPETWSVLEVSSFQLETATTFKPRIAMVLNVTPDHLDRHKTFERYWEAKARITACQESEDFLILNAEDVNAQKMAAKTRAQIYWFSGRRQVKQGAFVHGESVFFLGKEGGKPEPVLPVSEIALKGAHNVENVLAAVCAARLAGIDAETIRAAVKGFRAVEHRLELVRVRNGVEFYNDSKATNVDATVKAVESFAGGIHLILGGKDKDSDYATLSALLKERVRVVYTIGSAAEKIERQLDGVVKIVQAGTLDKAVKLAAEAAVSDEIVLLAPACSSFDQFTNYEERGRVFRDVVLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC1</accession>
    <name>E8WXC1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0382</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578782.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0382"/>
    <dbReference type="EnsemblBacteria" id="ADW67454">
        <property type="protein sequence ID" value="ADW67454"/>
        <property type="gene ID" value="AciX9_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0382"/>
    <dbReference type="eggNOG" id="COG2989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020360_3_1_0"/>
    <dbReference type="OMA" id="NIYLHHT"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045380">
        <property type="entry name" value="LD_TPept_scaffold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20142">
        <property type="entry name" value="Scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Scaffold" evidence="5">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="377"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="625" mass="69103" checksum="F400C9FD92503524" modified="2011-04-05" version="1">MMNPKFRKALTLSALSLVLLSGGCKRFRKTRSKPKSDAFADQLKPIVASKTIKVMHWPNYADYQPLVQTFYDDRNYEVAWVDNGQPTAQAAAFIQAFQSAAAKGLNAEDYDASLWTDRTRKLAAKDDNDTATFDAAMTVSVMRYISDLRIGRVNPTHFNFDIDVQQKKYDLPEFVSDNAVDADDVPKLIASVEPDSDQYRETEKALAHYNDLAKQQGTPEPLPAVDKPITSGGHYPAAEALAARLQLEGDLAGEPTAPEAPAPAPAPEAPKPTRTAAARASIGKAFARARGKSQAAPAATEAAAPPAHVPSTVYTADLADAVKHYQSRHSLTANGQLTAATVTSLNVPLTARSQQLADSLERLRWLPDPYLHAPLQVNLPEFVLRGFGEDHQQQFKMNVVVGQVVGEHQTPVFTHMMKYVIFRPFWNVPVSIIKKELAGHIAKSGVGYLEAHNFETVDAKGAHVNASAESIERGGVVVREKPGPKNSLGLIKFMFPNEYDIYLHSTPAQQLFARSRRDFSHGCVRVEHPDQLAVWVLQNTPRNWDLQKVTDAMQNGADNHQVNLTKQIPIVIFYATARVDENGQVDFFDDIYHYDKQLEDVLAKGMPYPSQQQHVDPKTKFGDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM5</accession>
    <name>E8WXM5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1588</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579960.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1588"/>
    <dbReference type="EnsemblBacteria" id="ADW68641">
        <property type="protein sequence ID" value="ADW68641"/>
        <property type="gene ID" value="AciX9_1588"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1588"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_0"/>
    <dbReference type="OMA" id="TQGKKDT"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15306" checksum="30F664A8760942BF" modified="2011-04-05" version="1">MAFSARGAGGKTRTQTAMADINITPLVDVVLVLLLIFMLTAPVLQSGIEVAIPHTRATSTMTDERVVITIDKDQNVFLQDKPINVADLGTRLKVNEKDPSTKTVYVRADERVPFGAFATVMESVKSAGITNISIVTQPYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT2</accession>
    <name>E8WXT2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2753"/>
    <dbReference type="EnsemblBacteria" id="ADW69777">
        <property type="protein sequence ID" value="ADW69777"/>
        <property type="gene ID" value="AciX9_2753"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2753"/>
    <dbReference type="eggNOG" id="ENOG5033AAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400757_0_0_0"/>
    <dbReference type="OMA" id="GESAMKI"/>
    <dbReference type="OrthoDB" id="2075132at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="20772" checksum="F5E724B561DECB41" modified="2011-04-05" version="1">MVMGSRLKVIDDARIRCLGATQDEGESAMKIAKITCTGAMVGMLMLGVGSVPMLAQASTAPVAQQPAENQPSLPTEARQGGRGGQMGGPRQVEMLTKQLSLTDDQVTKLKAIDADGMQQMQALRADTATPQEEKRPKMMAIRQAQETKIKAMLTDEQKTKYDAMIARMRERRAEGDGPGGSPPTVPPPSTPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT5</accession>
    <name>E8WXT5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leuB</name>
        <name evidence="16" type="ordered locus">AciX9_2756</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581095.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2756"/>
    <dbReference type="EnsemblBacteria" id="ADW69780">
        <property type="protein sequence ID" value="ADW69780"/>
        <property type="gene ID" value="AciX9_2756"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2756"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_0"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW69780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="369" mass="39313" checksum="C931E55F0F70CA9A" modified="2011-04-05" version="1">MKLNIAVLAGDGIGPEVTAEATNILRAVADLGGHDFTFTPALLGGVAITAAGTPLPEETLKISLASDAVLLGAVGDNKFNHLTPDKRPEAGLLQIRQHLGGFANLRPSVAYAALSENSPLRPEVTKDADILFVRELLGGLYFGAPRWWNHDTNEAINTMRYTRDEVVRVAKVAFELAGKRKKKVTSVDKANVLEVSQLWRATVTEVAKDYPEITLEHQLVDSMAMHIMNTPRSFDVVLTENLFGDILSDEAGVITGSLGMLPSATIGGKVNLYEPVHGSAPDIAGTGKANPLGAILTAAMVLRHSGKLEAEAAAVEAAVQHVLLAGHRTADIARGTDPAHVRVTTTQMGRLVHEALTQSLDRSQSMHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX1</accession>
    <name>E8WXX1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2793</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581131.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2793"/>
    <dbReference type="EnsemblBacteria" id="ADW69816">
        <property type="protein sequence ID" value="ADW69816"/>
        <property type="gene ID" value="AciX9_2793"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2793"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_4_2_0"/>
    <dbReference type="OMA" id="PVRSPWI"/>
    <dbReference type="OrthoDB" id="1421045at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="33075" checksum="9484613EAA74FE45" modified="2011-04-05" version="1">MHDTLSGAINRAKPAVRIPGMIQRALFDALAHDCLNLGQSAAYSAMVSLFPAMIVTAAIIALLPDTAPLRSQVGDFFDQVLPADVLPLLTSYFVASPGASPHTIRALILAAFVSFTGASSVIATLMEGIARANGLPRDCWTFGQRRMRAFLLVPISLIPLVLATILVVFGQFFSIWLALHLAPFIRPTFYAIALAVRWIVSLAGVVGLTALIYHLGTPLKQHWRRTLPGAIAATAIWFVSTLAFGWYVTRFANYGQVYGSLGAGIALLFWLYIVFLSVLVGAEFNSHFYQHFPPPDAPLPPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY6</accession>
    <name>E8WXY6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RND efflux system, outer membrane lipoprotein, NodT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0453"/>
    <dbReference type="EnsemblBacteria" id="ADW67525">
        <property type="protein sequence ID" value="ADW67525"/>
        <property type="gene ID" value="AciX9_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0453"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_1_0"/>
    <dbReference type="OMA" id="DFWGRFS"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="53659" checksum="AE63EED47AD7BCD2" modified="2011-04-05" version="1">MNATSSRQTAARAVLLAAGLSLTTGCMVGPKYVKPTVPTYQAPETFKDAYKESDPNWHPATPADAVLRGDWWNIFQDPELNKLEVEAGIQNQSLKSAAARYDGARAQIGINRADLFPTIGTGPSAGGIRYSDQRPFYTPSGSTPGQGTVALPLTFNYEVDLWGRIRRTVNIAKEETQASAADLQGAQLSIQSDLAVDYFEVRSSDAQYKLLAETIKDYQEALRITTNRFEGGVVPESDVFQAKTQLQAAIVQQHDVLVQRANYEHAIAVLVGQPPNSFSVPVAPLETKPPFIPYGLPSQLLERRPDIAAAERRAHEANERIGIARAAYFPTLSFNNSFGLQANTLGSFFSAGNLAYTLGPELDETLLDFGRRRGISNQAIAGYQQSSADYRQTVLTAFQQVEDNLSALRILTDEQEQQRQATEAAQGAQNIFNNRYVGGLDTYLQVVTAQQTALLNERNDIDIMRRRMDASVLLIKALGGGWSTANLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY67</accession>
    <name>E8WY67_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Squalene-associated FAD-dependent desaturase</fullName>
            <ecNumber evidence="5">1.3.5.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1642</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.5.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580013.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1642"/>
    <dbReference type="EnsemblBacteria" id="ADW68694">
        <property type="protein sequence ID" value="ADW68694"/>
        <property type="gene ID" value="AciX9_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1642"/>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022687_2_0_0"/>
    <dbReference type="OMA" id="HSMIFNQ"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052887">
        <property type="term" value="F:7,9,9'-tricis-neurosporene:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052886">
        <property type="term" value="F:9,9'-dicis-carotene:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016719">
        <property type="term" value="F:carotene 7,8-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017830">
        <property type="entry name" value="SQase_HpnE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03467">
        <property type="entry name" value="HpnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230063" evidence="3">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="453" mass="49639" checksum="75532421F03D21E0" modified="2011-04-05" version="1">MKPDVVVVGAGLAGLAAATALAEDGASVAVIERRPEVGGRVYSYEHPALGEVLDSQHVLLGCCTNLVDLCDWCGSGELIRWYDELTFLETNGNKSVMKPGILPAPSHQTLSFLRAPMLGVKDKVGIARGLMEFLRGYPEGDEESFATWLVRTGQTERAKRHFWEPVVVGALNDGFEQCSTKYAGKVFHETFLKSAEGGRLGIPKVPLTEFLAPIRRKAEELGVEFVKASVEELLQVDGGWVVKGGEVEVEAYAVVVATNFKEARKLVPGMADGPFVSAPITTVHLWYDRDVTGLDHAVLLDTRIQWVFAKSRIRGWTEGCYLELTISASWAELGMGREEILSSALRELEIFFPAVRGARLLKSGVLKEARATFSVTPGLDKFRPEQRTEWPGLYLAGDWTRTEWPSTMEGAVRSGRLAAGALRGELLRYMSPELAAGGLMKWLSTSRPALSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY75</accession>
    <name>E8WY75_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580021.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1650"/>
    <dbReference type="EnsemblBacteria" id="ADW68702">
        <property type="protein sequence ID" value="ADW68702"/>
        <property type="gene ID" value="AciX9_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1650"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_0"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="78"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="334"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="478"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="606" mass="65169" checksum="812D33E289B4380C" modified="2011-04-05" version="1">MPAPKRWVVTPPVSAATAALRSQLDCPEPIASLLASRGITDPKPFLDPSLDDLLDPLTLLGMTAAVARIEQAVRQGEKILIYGDYDVDGTVATVLLKTAIERTAAPGKPAQVTYHVPHRIREGYGMQTNVLGLAANSGITLVISVDTGIRAFAAAAEARALGLDLIVTDHHLPDGAAGIPDALAVINPAQPGCPYLNKNLCGAAVAFKLAQALLQNAAQTPDQQLRLKQTIIPSFLKLVAIATIADSVSLTGENRAIAWLGLRELANPIQPGLRALMQVAKLPLDRPPTATEVGFRLAPRINAAGRMDVASDVVELFLTRDSHIARELAQKLDDLNQDRRATEAAALEAIEMQLLTMTSPEGLYAPEVIVLSHPEWHRGVLGILASRVVDRTGRPALVMTESDGDAHGSGRSIAGFHLLDALTAIHDIDATLFTRFGGHAHAVGFSLPTTRLPLLRDRIKLHSTSLLIQEMLIPEIVCDLELMQADLTPDLCQWIDRCAPFGNAAPEPVFLTRNLILSAPIRIIKERHICIPLVSATGNSLSAMGWSRSSTPDWPTRCAAFDLRPGSAIDAVFRLRENKHPQYGGVELELIDLAPAQSPLNSPTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC8</accession>
    <name>E8WYC8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2811</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581149.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2811"/>
    <dbReference type="MEROPS" id="S49.005"/>
    <dbReference type="EnsemblBacteria" id="ADW69834">
        <property type="protein sequence ID" value="ADW69834"/>
        <property type="gene ID" value="AciX9_2811"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2811"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_1_0"/>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="OrthoDB" id="973681at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230454" description="NfeD domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="344"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="46374" checksum="DC38BE2B87410257" modified="2011-04-05" version="1">MSSLLRLWPALLVLLLAPAARAQPQPLVVKLTLHDTIQPVSAQYLHRGLAEAAALHASLVLLSLDTPGGLLDSTRTMVDDIERSPIPVAVFISPTGARAGSAGFFLLESADIAAMAPGTNAGASHPIIEGRTLDPILKQKLENDASAFLRSFTTRRNRNVEAAESAVRDSKSFSDTEALNLHLIDLVAPDDAALLTALNGQTIHRFDGTPITLNLTAATIQTIPPSPRERFLTTLTNPDLAILLLFAGVLLIYLEFNVPGTVIPGALGTFMVLLALFGLNLLPVRHTSAALVLAGLALMLLEFKIASHGILAFTGVAALVAGLATLVDAPIQELRVHTSTAVSAGFALGAITLWLAWIALRARRNKVLLGPDAMIGRLAIALTNLQPAGQVEVRGEIWQAILRDPAAFVALGESVLIREAHGLQLLVEASKNTPNTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG6</accession>
    <name>E8WYG6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2849</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581187.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2849"/>
    <dbReference type="EnsemblBacteria" id="ADW69872">
        <property type="protein sequence ID" value="ADW69872"/>
        <property type="gene ID" value="AciX9_2849"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2849"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079636_6_0_0"/>
    <dbReference type="OMA" id="MEMEFNR"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230461" description="DUF4142 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19251" checksum="2A912C6ABDB511B3" modified="2011-04-05" version="1">MKLTIASLALATILPLAAHAADTSHQDKKFVEDSGAGSLAEVQMGKLALQNSQNPEVRHFAQKMIDDHSMLIQTMKPFADKMGVPPPSKLDRAEKDEYDRLSGKKGQSFDKDYITTMVDDHHKDLADFTKERDTTANPDLKATVAKGREVILQHTVMIDGIAQKMNIPVPAKPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ6</accession>
    <name>E8WYJ6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0522</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578922.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0522"/>
    <dbReference type="EnsemblBacteria" id="ADW67594">
        <property type="protein sequence ID" value="ADW67594"/>
        <property type="gene ID" value="AciX9_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0522"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="TVIGNFR"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="252"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="483" mass="52404" checksum="6F198153D2030E2F" modified="2011-04-05" version="1">MRLNTLRARVVTWYVSMLAAALVVFGVALYLGVENYLRTSLETTLSGEANAIGTTFVAHEEAKGAVWMEGEIVEAYAPELSGRFIRITRRNGPVLYKSGDTREPIIEASKVPPAPAGAMAASFRTQVQENSNHLLIYAMPYKTSAGTEYWIETGVSLAPMQRVLSSMLDIVLLLTPLILIGAAIGGTMLMTGPLQPLVTLTERAEHIGISALGERLPVSDTGDEMERLALSLNRMITRLEDALSHNRRFSADVSHELRTPLTIMRGELEQVLLDTEVDSATRVSVFSALDEISRMSKIVESLLAIARLDSGADSINTLPTDVSELCRWTVEQMHLLAEEKNIGLEIETRPLMVMADSSRIKQVMVNLIDNAIKYTTDGGKIIVTTAATGKMASIEIRDTGIGIPPEALPHVFDRFYRVDKVRARISGGTGLGLSIVKAICHAHGGNITVTSKDGEGTTMRVMLPLLLSSPLSTIPAPAEQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM5</accession>
    <name>E8WYM5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0551</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578951.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0551"/>
    <dbReference type="EnsemblBacteria" id="ADW67623">
        <property type="protein sequence ID" value="ADW67623"/>
        <property type="gene ID" value="AciX9_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0551"/>
    <dbReference type="eggNOG" id="ENOG50338CX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2395586_0_0_0"/>
    <dbReference type="OMA" id="IWNTITV"/>
    <dbReference type="OrthoDB" id="1921551at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10808" checksum="8C8E667FC1335248" modified="2011-04-05" version="1">MANTLIPIEERNLTPDQVELLDRRRRRGQAFLVVAVQTTIISCLLLLWSGQDFTLTPGWVKPIVIWNTITVLIAISCYTIGIRLRRGTNEFFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN0</accession>
    <name>E8WYN0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation and condensation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578956.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0556"/>
    <dbReference type="EnsemblBacteria" id="ADW67628">
        <property type="protein sequence ID" value="ADW67628"/>
        <property type="gene ID" value="AciX9_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0556"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_2_0"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="308" mass="34668" checksum="4A6BAB351AC5C485" modified="2011-04-05" version="1">MADTEQSLAGSTEEIVPVAEAAPFVLEPKPEPPPAPEAKKSAPAKAKEEISLSPFSITVATVYDGPMDLLLDLIRKQNIDIYDIPMGTITAQFLEYCHVLKNTDVDAAGEFIYTASLLIHIKSKMLLPRDPLAGGAEDAEDPRRELVDRLLDHERFKAAAQMLMQKQQIEEATWSNPGIREFRDDSAAEPEIAADTVDLVRVFQDVLERLKQRPVLNVDEESVTVAQMIDYVKRRLLMEDKPVSLRRLLHNTHTERAVICMFLAMLELVRLQAILLHQPEVMGDILVKKAESFDQVFEDQAAARDDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP7</accession>
    <name>E8WYP7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0574</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0574"/>
    <dbReference type="EnsemblBacteria" id="ADW67645">
        <property type="protein sequence ID" value="ADW67645"/>
        <property type="gene ID" value="AciX9_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0574"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041032_0_0_0"/>
    <dbReference type="OMA" id="NCGTGED"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="30883" checksum="B5C05BCC071768CA" modified="2011-04-05" version="1">MSKPLNLKLMPGLAAGSAFDRIAASYDHLFTESLVGRAQRSAVWKVLLKTFHANDNILEINCGTGEDALQLAAHGISVFACDASGEMIAQAEQRLQRNDPAPPVVFCHLPTERIGELEPAVRFDGAFSNFSGLNCIADLTPVAQDLSRLVKPEGSLVLCLSTRYCFIETIYYSFRRRWDKAARRWKGQSEAWLEGAPLTVYYPTLRQVRRSFAPHFRLHSIQGVGVALPPSYLEPWAQRHTSLFNVLARLEGVISTWPILRTTGDHMLLRFERVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU2</accession>
    <name>E8WYU2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="10" type="ordered locus">AciX9_1730</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1730"/>
    <dbReference type="EnsemblBacteria" id="ADW68778">
        <property type="protein sequence ID" value="ADW68778"/>
        <property type="gene ID" value="AciX9_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1730"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_0"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="318"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="570" mass="61786" checksum="E2B81061D6835BF4" modified="2011-04-05" version="1">MVKIALAQINPTVGDFVGNTRKILEFAGRAADAGVDLVVFPELAVCGYPPADLLEKRAFVDRAGEAIGEIQQWTGIAGRPAVLCGSVMPSGVSEGKQVRNVAVLMQAGKVRAVQQKTLLPFYDVFDEQRYFEPATQQALTSIMTAKGEVPLAVTICEDAWNDKGFWPRRLYAIDPIERLMETWDSQPESLRGQAKVIVNISASPFWKGKQQVRQEMLAALAVRHGAVVAMVNQVGGNDSLIFDGASVVMGADGTLIGMGAAFVEDLVIFETGAVVEEPTSQKRDVGHPLDDIKAMWDALVLGTRDYVRKCGFSKAVIGLSGGIDSALVAAIAVEALGAENVMGVGMPSEYSSEGSKDDARVLAENLGVRFEMLAIHEGYEAYMKMLGPLFAGTPFGLAEENLQARIRGTLLMALSNKFGALVLTTGNKSEMSVGYCTLYGDMVGGLAVIADVVKTKVYELSRYANREREVIPVATLEKPPSAELRPGQKDTDSLPPYEVLDPILEAYVERYCSAEQIAGEQKVDVELVRQVLKLVERSEYKRQQAAPVLKVTRKSFGMGRRFPIAAKVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ20</accession>
    <name>E8WZ20_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2912</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581250.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2912"/>
    <dbReference type="EnsemblBacteria" id="ADW69935">
        <property type="protein sequence ID" value="ADW69935"/>
        <property type="gene ID" value="AciX9_2912"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2912"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_2_0_0"/>
    <dbReference type="OMA" id="WTWVVEN"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14675" checksum="26B49479A22C219A" modified="2011-04-05" version="1">MNVLDAIKRPSRAQKGYKGDLSSADCPSRGVLDHVTSRWGSLVLMVLLDGAHRFSELRRRIGGVSEKMLAQSLRALEGDGFVLRTVYATVPPQVEYSLTPLGLEVATHISGLTCWIEDNLPKVMSVRAKLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB8</accession>
    <name>E8WZB8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0649"/>
    <dbReference type="EnsemblBacteria" id="ADW67720">
        <property type="protein sequence ID" value="ADW67720"/>
        <property type="gene ID" value="AciX9_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0649"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_1_0_0"/>
    <dbReference type="OMA" id="DGPSWLI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="296"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="572" mass="64368" checksum="390E7C78775195C4" modified="2011-04-05" version="1">MKRLGQIAVIIGAGPAGLTAGLELLRRTGIRPVILEASGEIGGISRTIRYKGNRMDIGGHRFFSKSDRVMQWWMDLMPPEIAESEISYQGKKRSVAVPAKLEEVPVLRGVGPRAVVEIETETDETDADGTIHAGEHGHTDTIVTVEDHAADPDLVMLIRPRQSRIYYLRRFFDYPIKLTGQTLANLGITRTVRVGMSYMASRVSQIKPEKSLEDFLINRFGRELYLTFFKSYTEKVWGTPCDQISAEWGAQRIKGLSLTTAVKHFVKKAVRRRGKGGDLAQKGTDTSLIERFMYPKFGPGQLWEHVADQIVGMGGEIHMGWKVESIQCEGKTVKAVVGVNEAGDRQTFEGDYFFSTMPMRELVQAMDAPVPANVKEVSDGLQYRDFITVGLLADKLKVKEPDGGLLKDTWIYVQEPDVILGRLQIFNNWSPYLVSDPTKVWIGLEYFCYDTDDLWKMEDEALKQFAIDEVVKIGILDADAVSDGHVVRVPKTYPAYFGTYDRFDELRVFTDSFENLFLVGRNGMHKYNNQDHSMLTAMTVVDGLVAGKVDKAALWGINTEQEYHEEKEKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI1</accession>
    <name>E8WZI1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1822</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580188.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1822"/>
    <dbReference type="EnsemblBacteria" id="ADW68869">
        <property type="protein sequence ID" value="ADW68869"/>
        <property type="gene ID" value="AciX9_1822"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1822"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212676_0_0_0"/>
    <dbReference type="OMA" id="DYAGRGH"/>
    <dbReference type="OrthoDB" id="1539910at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="27168" checksum="81384B2350A115F5" modified="2011-04-05" version="1">MSVLLAPHLIPIFEHEYRELRPRAPIPPLDIRFRRFTSLNTTIRLREGKLLVRLSDILEPSPASVHHAIAHILLAKLYRKPITPAHSDRYRRYVSSEPVARQAEHIRTTRGRKNISTPIGHHYDLDEVFEAINRRFFHGLLGRPTLTWSAHAARRMLGHYDSAHNTIVVSRVFDRPDTPRCAIEYLLYHEMLHLKHPVRVKAGRRCVHSREFQAEERLFPELEQAKAYLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL0</accession>
    <name>E8WZL0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2961</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2961"/>
    <dbReference type="EnsemblBacteria" id="ADW69984">
        <property type="protein sequence ID" value="ADW69984"/>
        <property type="gene ID" value="AciX9_2961"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2961"/>
    <dbReference type="HOGENOM" id="CLU_2617043_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8476" checksum="42E91C824F976B5B" modified="2011-04-05" version="1">MTGIAIELYKSFTAGLGRMEAVCMRPFAIVPAPPSAPEFWDPMRMGYAGRNSETELAATPYLWVEVASSVTVDCISSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS5</accession>
    <name>E8WZS5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VbhA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0666</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579064.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0666"/>
    <dbReference type="EnsemblBacteria" id="ADW67736">
        <property type="protein sequence ID" value="ADW67736"/>
        <property type="gene ID" value="AciX9_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0666"/>
    <dbReference type="HOGENOM" id="CLU_2699538_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900723">
        <property type="term" value="P:negative regulation of protein adenylylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11586">
        <property type="entry name" value="VbhA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033788">
        <property type="entry name" value="VbhA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043038">
        <property type="entry name" value="VbhA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VbhA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8271" checksum="B0BB40D8A17A3BAB" modified="2011-04-05" version="1">MQPISDEEKSRRRRINQSVIGTNAMEGLSLDEETLSLMRRYEEGEIDREELSSAIDLHVARLLRERSALAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY1</accession>
    <name>E8WZY1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0722</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579118.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67792">
        <property type="protein sequence ID" value="ADW67792"/>
        <property type="gene ID" value="AciX9_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0722"/>
    <dbReference type="eggNOG" id="COG0384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_1_0"/>
    <dbReference type="OMA" id="IVNGMSQ"/>
    <dbReference type="OrthoDB" id="1468060at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="35026" checksum="C5798F68416FEEAD" modified="2011-04-05" version="1">MSTAGISGSGLPTSRRTLEYAIVDVFAERALEGNMLAIFTDARGLTTEQMQALARETNLSETTFIVPRDEAVEREQGVQVRIFTTQEELRFAGHPTLGTASWLYWNHPVLAGAEKITLELPVGPIPVRFDAPAEGEDGVFGTMRQNDASFGQVHDPETISRVLGIPIEDLDTRYPIQTVSTGMAFCIVPLRSVEALGRLAIPQQVAQTYLDTCDAKFFHCITPAQDADFRARMQFYTGEDPATGSASGCAIAWLVRYGLVESEQQVVIEQGVEMLRPSRISVRAKRAIPEAKEFPISDVFVGGRTIPVATGRFFLPFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X007</accession>
    <name>E8X007_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1857</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580222.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1857"/>
    <dbReference type="EnsemblBacteria" id="ADW68903">
        <property type="protein sequence ID" value="ADW68903"/>
        <property type="gene ID" value="AciX9_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1857"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_0"/>
    <dbReference type="OMA" id="IVHWKEV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="522"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="629" mass="67081" checksum="B5EFAC3002875BE4" modified="2011-04-05" version="1">MTQLNAVRDEEMKVAVGGSLGSLFEQARMRHGARVAVSMGADAVTYEALGARADAVAAGLARRGVGRGAVVAILMERSVDLVAAMLGVVKAGAAYLPIDPAYPEARVAETLADARPMVVIGKGGVSVEELAAGAGGEVAGEGAGAEDLAYIIYTSGSTGKPKGVMVSHGNVARLFSATDGWFHFDENDVWTMFHSFSFDFSVWEMWGPLLTGGRLVIVPFGVSRSPEDFYALLADEGVTVLNQTPSAFNLLVQAEGRVGRKPLALRTVIFGGEALNLRALKPWFERHGDQRPELVNMYGITETTVHVTYRRITAEDAERETDSLIGEAIPDLQLHLLDGELKPVAVGETGEICVGGAGVALGYLNRAELTAERFVDDPFVSGGVSGAKMYRSGDLAKRREDGELVYMGRADRQVKVNGFRIELGEIEAALVEFAGVAQACVVPLMGDGGVQRLAAYFVAASVDVDAKTVSKWLAERLPVHMRPAFYTAVTGIPLNGNGKVDRDALPLPEAMTSSLPDAPRLAPGSSMEEHVAAIWRQVLKTQAVGMDDNFFDIGGSSLMLIGVRSALAEELKRAIPITWMFECTTVRTLAARLGAGRETVTADAGNAADKARRQRDSFARAKALRSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X025</accession>
    <name>E8X025_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1875</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580240.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1875"/>
    <dbReference type="EnsemblBacteria" id="ADW68921">
        <property type="protein sequence ID" value="ADW68921"/>
        <property type="gene ID" value="AciX9_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1875"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_1_2_0"/>
    <dbReference type="OMA" id="QTIGGYD"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="42129" checksum="81DB55AFFD2B6F98" modified="2011-04-05" version="1">MLILHVLLILLGIALLLATLPLVIELLALSLAALLPPKPLTGSRSPESIGLTVVIPAHNEERLIVACVRSIVSSSAPNVTVLVIAHNCTDATAQCATAAGAQALILNDTIGGKGTALHYGFTQALAAGADAVLVIDADSIISANLTSAVTAALAAGSQALQCRYMVANPGNTTRTRLMSLAFLGINVLRPRGRARLGLSCGIFGNGFALSAQTLQAVPYLANSVVEDLEYHLHLIRAGIRVDFLDHASVLGEMPDTSAASSTQRARWEGGRLLMRRQWTMPLLNEVLRGRLRMIEPLLDLRSLPLATEGALLLLLLIPSFWFPFPWFGAYATLGLCTLLLYILVAATLGPEPAQTLKALAFAPGYMLWKILMIPSTRKAARKDSAWVRTERNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X055</accession>
    <name>E8X055_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1905</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1905"/>
    <dbReference type="EnsemblBacteria" id="ADW68951">
        <property type="protein sequence ID" value="ADW68951"/>
        <property type="gene ID" value="AciX9_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1905"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119519_0_0_0"/>
    <dbReference type="OMA" id="IQEFWVA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="21605" checksum="B8541F118A3197D2" modified="2011-04-05" version="1">MAPLSDSTSTGSSRPRVGGATVREAKLQDAVNIFELVNSLSGDGTLLRRNYAEICENVRDFQIAESEAGVFLGCGALHLYGPHLAEVRSIVVKPEAKGQGAGGKLLRALLEEAEYQGVVSVCLFTRIPDFFFHFGFRVSDRTALPDKIYKDCQTCPRLYACDEVAMVRGPLPRIAVLGPTKFPQPELVKLQTSVIPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X067</accession>
    <name>E8X067_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle synthesis GvpLGvpF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3027</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581362.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3027"/>
    <dbReference type="EnsemblBacteria" id="ADW70048">
        <property type="protein sequence ID" value="ADW70048"/>
        <property type="gene ID" value="AciX9_3027"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3027"/>
    <dbReference type="eggNOG" id="ENOG502ZAG7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065736_0_0_0"/>
    <dbReference type="OMA" id="WPPYHFV"/>
    <dbReference type="OrthoDB" id="1869432at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="27860" checksum="DDFE65F5E83AE576" modified="2011-04-05" version="1">MSWYAYCIAERQSFPELARHRRPVPLNGVAGLFGNQTFLFPAGELAVIVSEHGPADSARMDQQAAKDHARVIADCFKLSTVLPFRFATTFHDDDSLRRSVRSNQRQFLANVERLRGKAEMHLKVLVDDTCPGNSARDMTVGLQYLTSLRESAGRQRERQSKARALSVQMHRMFLPIAEEITCKRMESGKLLLDIAHLIDNKTVERYQNKYSSATQELKECRMQLSGPWPPYHFVHRTSGAQTTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K7</accession>
    <name>E8X0K7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1912</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580277.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1912"/>
    <dbReference type="EnsemblBacteria" id="ADW68958">
        <property type="protein sequence ID" value="ADW68958"/>
        <property type="gene ID" value="AciX9_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1912"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_0_0_0"/>
    <dbReference type="OMA" id="LTFEFRD"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10401" checksum="760B0CE5E854AE51" modified="2011-04-05" version="1">MIRTFKHAGLERFFMTGSKAGIQPIHAKRLSELLGALNAAATAEDLNAPSYRLHALKHDRAGDWSITVQANWRITFRFEGSDAILVNYEDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q4</accession>
    <name>E8X0Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage portal protein, HK97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580324.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1959"/>
    <dbReference type="EnsemblBacteria" id="ADW69005">
        <property type="protein sequence ID" value="ADW69005"/>
        <property type="gene ID" value="AciX9_1959"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1959"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033789_0_1_0"/>
    <dbReference type="OMA" id="YFVKFNV"/>
    <dbReference type="OrthoDB" id="389520at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006427">
        <property type="entry name" value="Portal_HK97"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01537">
        <property type="entry name" value="portal_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="49213" checksum="DCB16FFFC75C5197" modified="2011-04-05" version="1">MEVFSSIRALLDTRDKGHPISLELRQQPTLNTPSVPLSGVGFEWAYELGGGDGTVSGEAISNDTAMRIITVYACIRVLSQAIASLPLVLKEKIENGSTDAVASPLYYILGTEPNPEMDKHRFWATIVTGLMLTGNAYCQIVRNNAGQVVELYPLLPTITEPYRLDSGILAFRTQQGQAPGNWKTLPATDVCHFALMCLDGIKGMSPIHQAREGLGLARAAEKAGARLFGNGARPGGLLIAPADITPEQKEQARKSWQANHGGSNQNGTAVLEGDWKYEALSLSPEDSQFIQVRAMQRTEICALYGVPPNMAGDTSRLSNNNHEQTSLSFVTDTLRPILSTLECELNRKLMPKVGRKAGSYFAEFDLSERLRGDFATQMKGYAMGKQWGWYSTNDIRRKLRENTIPDPQADVYLYPVNMANADQLPAQADEENIEQQPVKEPEKEPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T7</accession>
    <name>E8X0T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3104"/>
    <dbReference type="EnsemblBacteria" id="ADW70121">
        <property type="protein sequence ID" value="ADW70121"/>
        <property type="gene ID" value="AciX9_3104"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3104"/>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108922_0_0_0"/>
    <dbReference type="OMA" id="HNAIDKR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="23559" checksum="570C3631570A441E" modified="2011-04-05" version="1">MDSTLEILTTNEAAVVAGVSVDDVNRAIDRKILPISLYRTTATRTVSRDACLWIAFWFETADLLTSAARQRLISEGSSRCPTWVELRTCKLQESRAIEVGFQGLWDEVNGRLNELGRAQDMVIEDPEILSGTPVIRGTRIPVYDVASLIEADTTSVELKDLYPRLSEEQFKLAQVYAKARPLRGRPKRRSLPESRRISVSKKHLRETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X184</accession>
    <name>E8X184_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69038">
        <property type="protein sequence ID" value="ADW69038"/>
        <property type="gene ID" value="AciX9_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1992"/>
    <dbReference type="HOGENOM" id="CLU_2493543_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9204" checksum="6B2ADA1477997621" modified="2011-04-05" version="1">MFDKSTNSGESSSAPSGTPEGGYASLGRTIGDVLDTILSEPRRLATLILMLASFALMALLFMFIFSKLFTVQPAEVQLGNTSSHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C0</accession>
    <name>E8X1C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2029</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2029"/>
    <dbReference type="EnsemblBacteria" id="ADW69074">
        <property type="protein sequence ID" value="ADW69074"/>
        <property type="gene ID" value="AciX9_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2029"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013746_1_1_0"/>
    <dbReference type="OMA" id="RKERQHT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLT" evidence="4">
        <location>
            <begin position="638"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="781" mass="84890" checksum="1F36F42B991219CE" modified="2011-04-05" version="1">MGLPGCAWASALKKPAKAASHVQKGKAATGKAGKKGAVSARAAKGAKGKAVASGRGEKKLPERKLTKAEKAAEAKRSAAETTQVVKLNSAFVATTQLRPMAQQLASTRSGASYNGVLTYAGGHPGIGAATAYLALGHAYALDHKYADAADAYKRVDAAGDALSDYADYLGAQALIQAQRGSEAYGLLDHFGDRHPDSIFAATAPVLLANAYLDQKNPSGAVSALQAVAGTAEADHVDYKFALAKAYQAQGESGKAAGLYRYIYVATPLSYEAGQARAQMLAMGQGPTAAERKVHADQLFNAKRYGEASIEYASVKNDSSLGQADRDALEIYSAVCDLKLKRLSRRDVDKLPATTDDTAALKLYLYAEISRTEKDRVSHQSIITQMVDKYPNSRWTEEALYSGGNMYLLTHDSTQALYHYGLLVQHFPNSTYAPSAHWRMAWMNYRLRRYPEAARLMDEQVVRYAAGTEASSALYWRGRIYEDEEKDFGQAANYYRALSANYNNFYYGVLARQRLAVIGRQAGETAASPVLSSVRKLNIPDLTDVIPVGDPHYIKAKLLANAALNEYIGPEIAASPGSGEWGALAQAQIYASYGEITRSLQSMKHSGISFFSLPTSQVPMGYWRLMFPQPFWGDLTSDAAKNGLDPYLVASLIRQESEFNAGAVSPAKAYGLMQLLPGTGKDNAKKEGLRGFQTSWLLNPALNLQLGTRNLRGVLDRFGGQPEYALAAYNAGDVPVRSWMASGDYKDIAEYVESIPYTETREYVQAIMRNREMYKTLYGPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C9</accession>
    <name>E8X1C9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">AciX9_2038</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell inner membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2038"/>
    <dbReference type="EnsemblBacteria" id="ADW69083">
        <property type="protein sequence ID" value="ADW69083"/>
        <property type="gene ID" value="AciX9_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2038"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ADW69083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="19636" checksum="0E6988D444C0B20A" modified="2011-04-05" version="1">MITEPQTRPAALARRTNPAYALLAAVQFLTRIPTPQIPYTDRTLSDALAYFPLIGLLIGTLAALVNQFLAPHLSRPLSALCTVTFTVLITGALHEDGLADCADAFFGHHSRERTLAILRDSRIGTYGAAALALSLGARVLLVAALPLNHVFPYLIAAHTLARWSPLPLSYLPPPAPKTAREPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D5</accession>
    <name>E8X1D5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ordered locus">AciX9_2044</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2044"/>
    <dbReference type="EnsemblBacteria" id="ADW69089">
        <property type="protein sequence ID" value="ADW69089"/>
        <property type="gene ID" value="AciX9_2044"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2044"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_1_0_0"/>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="36491" checksum="0DE6ACDD0E62EE47" modified="2011-04-05" version="1">MTSRQSSRAPSTRSFIAIGWESKCRSAGSSRLSRPTLITSAATLDWLLGDPESLPHPVRLIGKAIAAGDHALYREDRTPTYNFLAGSALTFALVAATWKLTAVLIKHLPKPFEILLASTCLASRNLDDEARAVLTALELDDLPQARQRIARIVGRDTAHLDEPAIARALIETLAESAADGILAPLFFLAIGGVPAAMAFKAISTLDSMIGHRTKRYLHFGKTAARLDDLANLIPARLTALLILATNPSPAAISTYSQDHNKHASPNAGHPESAMAGTLGIQLGGPSTYDGEPHTAPILNASAPLPTRTYARRALHITRAVSLLGTALAIAIAYNTTRRRSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K3</accession>
    <name>E8X1K3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">AciX9_3227</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581550.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3227"/>
    <dbReference type="EnsemblBacteria" id="ADW70238">
        <property type="protein sequence ID" value="ADW70238"/>
        <property type="gene ID" value="AciX9_3227"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3227"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_0"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="29590" checksum="FD77F3FF10764DF0" modified="2011-04-05" version="1">MAVLVDKNTRLIVQGITGREGLFHAQGCRDYGTNVVGGVTPGKGGTTVDGFPVFNTVAEAVASTGANVTVIFVPPPFAADGILEAAAAEIPLVICITEGIPTLDMVKAWDIVKASKSRLIGPNCPGVISPGKAKVGIMPGRIHKEGSVGIVSKSGTLTYEAVYQLTTRGIGQSTAIGIGGDPIIGTTHIDALKLLNEDPETEAIIMIGEIGGSAEEAAAKYIKENVKKPVVGFIAGQTAPPGRRMGHAGAIISGGEGTAAEKMKAMAEAGITVVKSPAEIGEAMALLLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y3</accession>
    <name>E8X1Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="8">1.14.16.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2100</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580460.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2100"/>
    <dbReference type="EnsemblBacteria" id="ADW69144">
        <property type="protein sequence ID" value="ADW69144"/>
        <property type="gene ID" value="AciX9_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2100"/>
    <dbReference type="eggNOG" id="COG3186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023198_1_1_0"/>
    <dbReference type="OMA" id="KQFPVAT"/>
    <dbReference type="OrthoDB" id="1492162at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27968" checksum="E3BA0ADCC4747A67" modified="2011-04-05" version="1">MAVILEQTSGLRVAQPFLIEQDWAGYTAEQHGVWGELVARRMPQLRNHACAEYLDGFEQIGLSETALPDLGAVSARLGPRTGWASTPVSGFLPGDAFFEMLAARRFPTTTWLRSREAMDYTPEPDIFHDVFGHVPMHAHPVFADFLQHYGQVCANLIDRPEALERLGRLFWFTVEFGLIRQAGEIKVYGSGLISSHGECTRVLAGGCEVREFELDAVLGQEFDTGAMQPVLYAVESFEQIYEAAKEAEGKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X231</accession>
    <name>E8X231_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3263</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581586.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3263"/>
    <dbReference type="EnsemblBacteria" id="ADW70274">
        <property type="protein sequence ID" value="ADW70274"/>
        <property type="gene ID" value="AciX9_3263"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3263"/>
    <dbReference type="eggNOG" id="COG3910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079631_2_0_0"/>
    <dbReference type="OMA" id="MSHGESF"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="29364" checksum="623A7CF2A90AFCC0" modified="2011-04-05" version="1">MLKSITLLPERITNPTAYPFSVPAISTFRRLDITSRVLCFAGENGTGKSTLLEAIAAHIGFGREGGNRDMRFETSESVAATEPLIRALRLGFDKRTGEGFFFRAESLFSVATQIDEWDSDSSFGGKIRDSYGGVSLHDHSHGETFFTVLDHKFRRSGLFLLNEPEAALSPQRQLAFLVLIHATLRDYKDAQFIISTHSPLLLGYPGAQIVSFDGGRLQPIDYDRTYPYLIIRRFLTDRTQMLEDLFRNPEADPDDQSTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A4</accession>
    <name>E8X2A4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0969</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579360.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0969"/>
    <dbReference type="EnsemblBacteria" id="ADW68036">
        <property type="protein sequence ID" value="ADW68036"/>
        <property type="gene ID" value="AciX9_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0969"/>
    <dbReference type="eggNOG" id="ENOG5033RG3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775596_0_0_0"/>
    <dbReference type="OrthoDB" id="1609677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="357" mass="39673" checksum="1E9862968ED38981" modified="2011-04-05" version="1">MAQRRSMLLHGLRITLSRPRAVVWTYVFNLGLALLFSIRFNAGLNDILGHSLGAQRLTTAFDLGVVAAAIERVNRDAPSTGLAGMIGPAFYVLIYFLLVPGTLFCYQTEAPARLSILLSIGFQRFWRFVRIAVFTLIVSAVILGPLLAIQTVWSTHVDDTTVGVAAIYEKLAGWLIIAIVAAIIRLYFDLVEVYTLFLGDQLRPTGRPDRRVHRVLLPALRTLRLNFFRALGSFLSLAVVGFLALFLTARLAMHMLAQPRVWPMFLVAQLGLFIMLFTRFWQRGAETTLAFDHPLPIPKIAAPLPPPVFFPDPVDDEPDPIPYPAPQHLDAQPNPEPATPSLDEPDPGVFHHDPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C7</accession>
    <name>E8X2C7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0992</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579383.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0992"/>
    <dbReference type="EnsemblBacteria" id="ADW68059">
        <property type="protein sequence ID" value="ADW68059"/>
        <property type="gene ID" value="AciX9_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0992"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_0"/>
    <dbReference type="OMA" id="INISTMA"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16048" checksum="ADE7BF30822F46F8" modified="2011-04-05" version="1">MDAEIFRRPGHLITRCARLLQRAGEQLFKPLGLGIAQLPVLYSLKGGNSMTQTELATLARIEQPTMAQLLTRMERDGLIRRSPNPQDKRSSLIALTPLALGKLPAARSLLLEGSRDALAGFSEVEIATLSQLLLRVVKNLDPEAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D6</accession>
    <name>E8X2D6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1002</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1002"/>
    <dbReference type="EnsemblBacteria" id="ADW68068">
        <property type="protein sequence ID" value="ADW68068"/>
        <property type="gene ID" value="AciX9_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1002"/>
    <dbReference type="eggNOG" id="ENOG50309MK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059693_0_0_0"/>
    <dbReference type="OMA" id="WVISINL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009492">
        <property type="entry name" value="TniQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06527">
        <property type="entry name" value="TniQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="327" mass="37429" checksum="87B74985B9954576" modified="2011-04-05" version="1">MISSWLLRIALRNGMKPQSFCKLLWPNRSFWNHSIDRYASQDLLEDLSRCTATPLQTLQKHSLAAYKGILFADLIRNGNTPWVLPLGIFHRRFRRTGLSFCPECLATGEPYFRRRWRLSLATLCLIHKRPLLDGCSVCHEPLQPHRIDMGSKNPYTSAAVFRCSACSFDLRSARSSTLTDLWLWKSESASDQFLTATPCEAARAMEYFSVLRHLLFMLTSRRSRLTPFRTLAASAIPSPLVESWKKDDETSLGFDAMRIDVRRVFIGAAYWLLEDWPRRFLDLACAARLRGSDLTRDFPSMPTSFAVVAANLPARQNELVLHQVMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E7</accession>
    <name>E8X2E7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1016</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1016"/>
    <dbReference type="EnsemblBacteria" id="ADW68079">
        <property type="protein sequence ID" value="ADW68079"/>
        <property type="gene ID" value="AciX9_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1016"/>
    <dbReference type="HOGENOM" id="CLU_760229_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009492">
        <property type="entry name" value="TniQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06527">
        <property type="entry name" value="TniQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="364" mass="40901" checksum="DB407C34B474BC33" modified="2011-04-05" version="1">MGSVKAFDEYPSFDSSDFDQLLPPALIACLADNLSFSPDFLLKASLVRFSEKFQEPHQSEITKWLLPRPKLLSGKGGHFRGSHFQGGGQYCPLCLDQADPYLHISWRFSFVTVCSLHKRVLSDRCPHCIAPVDTAKPAQFLDCADVRLHLRCKYCEGDLRGGSIDEVQGLSSNSMQSILQLQDDHLSLALNRHDNSDQISDYFAILHWAINSQLLNGNWKARPVRSEVLWMSQAPVRFLREVTEDCEVQDLGPLHLRASFKSLTAVTRAKLLSNCAEMLGRWPVNLRELATHFAGIRSSLRDSRSKLPNWVLPTLDCSVELPNRGPFRISLAQKVRSSVSGPTSPNHSVKPQICSDLSKRTLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K1</accession>
    <name>E8X2K1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2181</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580541.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2181"/>
    <dbReference type="EnsemblBacteria" id="ADW69225">
        <property type="protein sequence ID" value="ADW69225"/>
        <property type="gene ID" value="AciX9_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2181"/>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_0"/>
    <dbReference type="OMA" id="YGVISQM"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230186" evidence="1">
        <location>
            <begin position="28"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="39"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="283"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="768" mass="84624" checksum="02D82B58FD9262CC" modified="2011-04-05" version="1">MSSRREFIQGTAGVCAAAWLSSAAVLAEPSAQEEEVLRWVDPRIGTGGHGHCYPGASVPFGAVQLSPDTFNDGWDWCAGYHVSDSSIMGFSHTHLSGTGCGDLLDFLVMAGTGPAKIVPGTREKPEDGYRSRFSHEDEVATPGYYSVLLKDYQVRAELSATERAGIHRYTFPASDEAYLILDLQHAYLDDGKPTVVSSELKRIGPDTFTGGRVTKAWGNGRHAYFSMQLSKAPTRVVYYSDDKEVPAGALEGKNLKCVMYFKTKAQETILVKTGISGVSAEAAGKNVKAEIPAWNFEKVRSDARAKWSRQIGKIQVTSANEAHKRVFYTALYHMSLGPTLFDDVDGTYRGMDQQMHTLPAGRHNYTTFSAWDTYRAAHPAYTLIETERVPDFVNTLIRMAAESPQGMPVWPLQGCETGTMTGYHSAAIISEAINKGFKGIDEQLAYQVMMKRAMVDNYRGLGYYRKMNYIPADLEDESVSKTFEYCYDDWAIAHVSKKLGKSDDAALLVKRSTNYKNYFDPSVGFMRPKLQDASFTTPFNPIDMGHMKKWRDYTESNAWQTTFAVQHDPAGLIALFGGREPFLAKLDELFTTASTLPADAPPDIAGMVGQYAHGNEPSHHIAYLYVYAGAPHKTQARVRSLMETMYSPNPDGMQGNEDVGQMSAWFLLSALGFYPVDAVSGNYILGSPLFEHATVNVGGGKKLEIEVKRSDPAHAYIQAFSLNGEPQQKAWFHHSDIAQGGKLSFQMGPEPNLTFGAAPEVVPPSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L5</accession>
    <name>E8X2L5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2195</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580555.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2195"/>
    <dbReference type="EnsemblBacteria" id="ADW69239">
        <property type="protein sequence ID" value="ADW69239"/>
        <property type="gene ID" value="AciX9_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2195"/>
    <dbReference type="HOGENOM" id="CLU_198009_0_0_0"/>
    <dbReference type="OMA" id="YISCSAC"/>
    <dbReference type="OrthoDB" id="1984401at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6554" checksum="A4E7DB7220967534" modified="2011-04-05" version="1">MSKIAKTGDRAKVMDTNKSTDCPKCGKLTRIVKRVKDRERGIPGGVYISCSACDFFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L6</accession>
    <name>E8X2L6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580556.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2196"/>
    <dbReference type="EnsemblBacteria" id="ADW69240">
        <property type="protein sequence ID" value="ADW69240"/>
        <property type="gene ID" value="AciX9_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2196"/>
    <dbReference type="eggNOG" id="ENOG502ZCHX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741723_0_0_0"/>
    <dbReference type="OMA" id="DINGGPY"/>
    <dbReference type="OrthoDB" id="1249283at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234303" evidence="2">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="388" mass="40832" checksum="0AF1090D9CF0EEEC" modified="2011-04-05" version="1">MTTCVRSLSLAVGLVMVSVGAGGQAAPGAQDGAKDGAQAAAAKSEVFTVGERSATAGINTEFTPTHVEFDESALSERGRRELIRDLVGEQGFAHRVLPQAAGLTLQANGNLKPGPEEYKKLIYEKGTSAGPGDRVAITALEFKGDRLVIDLNGGPYLKHRFLRHVSIMGADPAYLDGKEATGSRVVLVFEGGLPEVTAPEVKALLAPVVDFAAKKGELAYADTLPTPVKSAIASHEVLVGMNHRMVLAALGAPESKVREQNGEGRYEEWIYGHQPQTVKFVRFVGDRVSLVKIAEVGKPIAVHDQDELAGYLPPAPTREISLADRVGEGQKASAPTLLKPGEKTLETGDTQRKVQVPVDPTSAGNGSGHAPTAPAKTPDQFVAAPSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M5</accession>
    <name>E8X2M5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3311</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3311"/>
    <dbReference type="EnsemblBacteria" id="ADW70322">
        <property type="protein sequence ID" value="ADW70322"/>
        <property type="gene ID" value="AciX9_3311"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3311"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26870" checksum="ABFE73CA3CCC1A1D" modified="2011-04-05" version="1">MHGRGGPSISVREACKTGAYDTTLIEGCLSLLQHAIDDKPSLILFDVEVWKGPVEEALCRLGELRAARFIRKVILTSHSDLDDKVDALEAGADDFLEKPISTRELIARIDAVLRSSVCMAAEEEEVHALGDLLLYREGMEVSLGEKRKRLSPTEFHLLAYLMDQAGHVLSRDELLENIWFPRAEIEERRVVDVYIWRLREKIEADPSHPRRLLTKRGSGYLLVDPQAQGAAAEVSDAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R4</accession>
    <name>E8X2R4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ordered locus">AciX9_3353</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581673.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3353"/>
    <dbReference type="EnsemblBacteria" id="ADW70361">
        <property type="protein sequence ID" value="ADW70361"/>
        <property type="gene ID" value="AciX9_3353"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3353"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_0"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="280" mass="30312" checksum="2812A86EDCF6DB7B" modified="2011-04-05" version="1">MLLAIDVGNSNTVLGLYRPTDGSALHFDPDPITNWRITTPRSRTTDEFGVILRSLFESNGHALTAVTGIAISSVVPPMDHILRQVSEQYFKQRPLFVEPGVRTGLPVLTDNPAEVGADRIVNCVAAFEHFRSPCIVVDMGTATTFDVVSAKGEFLGGAIAPGLGISADALFTRAARLPRIEVKRPAKVIGTGTVDNIQIGLYYGYIGLVDGILERMILELALTNGPMENIRTIATGGLAGLIAAGSKYIGEVDPNLTLTGLRLVFERNLERQEKQRRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R5</accession>
    <name>E8X2R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/acetyl-CoA-carboxylase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581674.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3354"/>
    <dbReference type="EnsemblBacteria" id="ADW70362">
        <property type="protein sequence ID" value="ADW70362"/>
        <property type="gene ID" value="AciX9_3354"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3354"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_5_2_0"/>
    <dbReference type="OMA" id="WPNDIMS"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="26743" checksum="AF167246903E393C" modified="2011-04-05" version="1">MPLSPETKATILGPLTHLATTTSTNQLALEAAQQGTRSGVWLADEQTAGRGRGGHTWHSAPGDGLYVSILATPRIPLAQAIHIPLATGLAAQSAIQEITGLTADIRWPNDLLLGTKKCGGILVESTSESGPDPLLRYAVIGVGINLNHAAFPPDLAKLATSLRIESDRPVDRDQLLEAFLTHLHRELDTLTTSNLLTRFAQSSTWVTGKRVHVDESGGYTGLTCGLNPQGFLQVRTPEGDIRTVLSGGVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T7</accession>
    <name>E8X2T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3376</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581696.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3376"/>
    <dbReference type="EnsemblBacteria" id="ADW70384">
        <property type="protein sequence ID" value="ADW70384"/>
        <property type="gene ID" value="AciX9_3376"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3376"/>
    <dbReference type="eggNOG" id="ENOG502ZAR1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959036_0_0_0"/>
    <dbReference type="OMA" id="WLNNPPG"/>
    <dbReference type="OrthoDB" id="1332630at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234119" evidence="1">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="29384" checksum="3229A7F48F7527AB" modified="2011-04-05" version="1">MKLSLSLLCFALTVTAVAQKAFVGFDRNDYPGDARLADLHQRFAFTGYWLNNPPGTTSNSWQSKRLQLRSAGFGFLVLWNGRLDAEIKKSKLSPKALGQQDAAAAIAAANRESFPSGTILFLDQEEGGRLLPEQAGYFFAWTETIAASAFKPGAYLSGQPAPDGTDSKGKPVFITTAQLVRAYIALANLHPVTLWVAQDTCPPSPGCTITPPPLKSSGTPGADIWQYAQSPRRPELTRSCASTYAPDNNCYGGASKDLAIDLNVANSSDPSHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T8</accession>
    <name>E8X2T8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3377</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581697.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3377"/>
    <dbReference type="EnsemblBacteria" id="ADW70385">
        <property type="protein sequence ID" value="ADW70385"/>
        <property type="gene ID" value="AciX9_3377"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3377"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105789_1_0_0"/>
    <dbReference type="OMA" id="GWTIRQV"/>
    <dbReference type="OrthoDB" id="1812981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="21836" checksum="11E67769432D080B" modified="2011-04-05" version="1">MKGDSRQGERRKAERSTDPRYPIGPFVAPEVVSADDRLGAISVLAELPDRLRHAVNRLDHHQLATPYREGGWTLRQVVHHVADSHMMAFIRMRLALTEDWPKVPSYDEAACSRLHDSSAPVEWSLELVESLHARWVMLLQSLKEEQWQRGFVHSAYGRTTVDLAAQEYAWHSRHHVAHIMHLRYARHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V9</accession>
    <name>E8X2V9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">AciX9_1030</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579416.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1030"/>
    <dbReference type="EnsemblBacteria" id="ADW68093">
        <property type="protein sequence ID" value="ADW68093"/>
        <property type="gene ID" value="AciX9_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1030"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_4_2_0"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="36653" checksum="AF408AA3BC940013" modified="2011-04-05" version="1">MAFSFFGKRNQQQESEQQPEEPTQTPASEEIDPPRRGLFDRMRQAVTRTRESFSDSIGQVLALTREVDESTLIDLEPILLAADIGSATTAIVLENLRQRALRKGIEGGSELKELLRVELKSILDGVSQQTIPAVAAPEVIMMVGVNGTGKTTTTGKLAAYFRRQNRTVLLCAADTFRAAAIEQLEVWATRSDVPIIKTKQGGDPSAALYDACTAAKARGTQVLIVDTAGRLHTKSDLMKELDKMRRTAERLVPGAPHQTFLVMDATTGQNGLQQARLFTEAARVTGIVLTKLDGTAKGGIVLAIATELKLPVVYAGTGEKIDDLIPFDSSTFIDSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W2</accession>
    <name>E8X2W2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">AciX9_1033</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579419.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1033"/>
    <dbReference type="EnsemblBacteria" id="ADW68096">
        <property type="protein sequence ID" value="ADW68096"/>
        <property type="gene ID" value="AciX9_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1033"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_7_1_0"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21772" checksum="572D0348996B65F4" modified="2011-04-05" version="1">MNPWLISIPLAYLLGSIPFGYLLVRFFRKQDIRETGSGNIGATNVARSGAKGLGLLTLALDLLKALIAVKIATHLVPANFDVAVGAAIAAIVGHMFPVWLGFHGGKGVASGLGVFLALAWKPSLVMFGIFLVIVFATRYVSLASMIAASTYPILAWLFHHQETAFTAFGYVIIPVLIIVKHHSNIRRLLAGTESRFGSKEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X2</accession>
    <name>E8X2X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1043</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68106">
        <property type="protein sequence ID" value="ADW68106"/>
        <property type="gene ID" value="AciX9_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1043"/>
    <dbReference type="HOGENOM" id="CLU_3067123_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021738">
        <property type="entry name" value="DUF3309"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11752">
        <property type="entry name" value="DUF3309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="4975" checksum="79478BDFAA410A7B" modified="2011-04-05" version="1">MLILLIILIIVFGFGGFRMGPGLGYYGGGGLSLILTIVLILLLLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X304</accession>
    <name>E8X304_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1075</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579461.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1075"/>
    <dbReference type="EnsemblBacteria" id="ADW68138">
        <property type="protein sequence ID" value="ADW68138"/>
        <property type="gene ID" value="AciX9_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1075"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_0"/>
    <dbReference type="OMA" id="IILDYMM"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13949" checksum="97CF08A1C5F7275F" modified="2011-04-05" version="1">MRTLIVDDSNFIREYTKQLLQKMGAVCTEAGNGVDALAVLMTDGKFELMLIDLNMPKMNGLECLKRLKETGLCEPMKIMMVTTEADHHFINEALEYGADEFLMKPFTPQSLKEKLLLLGFEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C0</accession>
    <name>E8X3C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3415</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581733.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70421">
        <property type="protein sequence ID" value="ADW70421"/>
        <property type="gene ID" value="AciX9_3415"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3415"/>
    <dbReference type="HOGENOM" id="CLU_2193258_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234319" evidence="2">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="11283" checksum="15FD8BA38E43DE0B" modified="2011-04-05" version="1">MALTKTSTRFRLLAPYFLALSSMAVAQQPAQTPQAPATSQTPAAPGEATTTTAAATPLTKKELKAQKKQQKAAEKAASENAQAQKDQANALKHQDKAANAAQQANPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K7</accession>
    <name>E8X3K7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ordered locus">AciX9_1135</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579521.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1135"/>
    <dbReference type="EnsemblBacteria" id="ADW68198">
        <property type="protein sequence ID" value="ADW68198"/>
        <property type="gene ID" value="AciX9_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1135"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_2_0_0"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="210"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="33464" checksum="D794C09CE860E4A0" modified="2011-04-05" version="1">MKLVFCGTPEFAVGTLEAVIEAGHQVALVVSQPDRAAGRGMTLQVGAVKAAALRLGLPVVQPEKIKNNLELRERLEAIAAEPGGLDAILVVAYGRIIPDWMLALPKHGCINLHGSLLPKYRGAAPIQWAVAKGETLTGVTTMRLDAGLDTGPMLLAQVEPIAPEETAEDLFESLAEVGSKLMVKTLAGLEDGSIDPVEQDHTAATLAPILKREDGRIDLTLGAKVCVDRWRGFQPWPGAWTSLRGKKLIVQRMCVGEGACVAGEVRVVGDRMFVGCGESEIELLEVQMEGKKKMAAAEFLRGFQVKTGERVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S6</accession>
    <name>E8X3S6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2317</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580670.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2317"/>
    <dbReference type="EnsemblBacteria" id="ADW69354">
        <property type="protein sequence ID" value="ADW69354"/>
        <property type="gene ID" value="AciX9_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2317"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902853_0_0_0"/>
    <dbReference type="OMA" id="WISSFEH"/>
    <dbReference type="OrthoDB" id="1074623at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230203" evidence="2">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="355" mass="37072" checksum="4D4E542A575953F2" modified="2011-04-05" version="1">MPFKTPSRSTLLSLAVASSLVLAPFLHTQQPEPPKAPSLPTEAPTPAAPAKPRPPRIVRPGVATPGVSLPLDALKHDAVFPVEGSPDWSVVTKDAVWVSSARANHVVQLLPATNTVGLIADVKRPCAGLADAFGSIWAPSCGPTKEIERIDPATGKITASILAEAANSEGGITAGAGSIWFVIKTSKLIRIDPKTNAIASTLDLPTGSENPAFGEGFVWISSFEHDQLLKVDPATNKIVATIPIGPKPRFLTVGGGSVWTLNQGDGTISRVDMKSGKLAATIKCGIPGEGGEISFGEGSVWAAMFDFPLTQVDPKTNTVVKQWAGQGGDGVRAGLGSVWLSNLRQANVWRIPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y2</accession>
    <name>E8X3Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Primosomal protein DnaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3485</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581801.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3485"/>
    <dbReference type="EnsemblBacteria" id="ADW70490">
        <property type="protein sequence ID" value="ADW70490"/>
        <property type="gene ID" value="AciX9_3485"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3485"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_3_2_0"/>
    <dbReference type="OMA" id="GSPFEME"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="30"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="28780" checksum="818CF160FB3EEA6B" modified="2011-04-05" version="1">MEQEVCPHCNDSGLRTFTREDGERFVRDCSCRVERRVRRMIARSHIPRRYEHCSLDSFETDFKDATRSLKTAHFSARKFVESYPIETGGTGLLLTGSIGVGKTHLAVGILQALVAERGATGLFVDYRELLQKVKNSYNPQVQSTELEILKPVFDAEVLILDELGASKPSEWVWDTVAHILNTRYNDRRTTIITTNYANAAPLDGTVKELGRAAREESLGDRIGERMRSRLQEMCVVVEMHGVDFRQTVNLARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X463</accession>
    <name>E8X463_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0032</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578452.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0032"/>
    <dbReference type="EnsemblBacteria" id="ADW67123">
        <property type="protein sequence ID" value="ADW67123"/>
        <property type="gene ID" value="AciX9_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0032"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066428_0_0_0"/>
    <dbReference type="OMA" id="SLGSCYA"/>
    <dbReference type="OrthoDB" id="584516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="DUF2048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="45291" checksum="CD2E2FD15927A86C" modified="2011-04-05" version="1">MFSRLYAKWMFAWETALTTRDTNRIVRPVEWGFDWLPPLTTPMPGASDEAQMTALSAQIAAQSDEFFAYATPSDFRLEERHPQLFPTNVRPETLAQDADLKRKASSGKLKAASFLRFTSAASTPYPENDQVNARWYPASPEQEEKFRRLGKPRQAMIVMPQWNADAFSHNALCEIFNRFGISCLRLSKPYHDIRRPAELERSDYAVSANIGRTMAACRQAVVDIRSCIDWLSQQGYEQFGVLGTSLGSCYAFIAAAHDARLNVCAFNHASTWFGDVVWTGQSTRHVREALEQAGLTQITTREVFRAVSPMAYMDRFAANPKRVLVVHAKYDLTFLEEFSLDVLKNFNEYGIDYVSRVLPCGHYTTGETPYKYIDAWYLGSFIHDAFKKLAFENLKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X482</accession>
    <name>E8X482_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0051</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0051"/>
    <dbReference type="EnsemblBacteria" id="ADW67142">
        <property type="protein sequence ID" value="ADW67142"/>
        <property type="gene ID" value="AciX9_0051"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0051"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024481_0_0_0"/>
    <dbReference type="OMA" id="YFLNEGV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="56217" checksum="9AFFF3A9BACAABF6" modified="2011-04-05" version="1">MMIGENAQGYPRASLKDVPPGEYTVQAVLNVYETFQRGDGKMVKLAPDRGEGQHWNLAPGNLMSKPRKVKIGPGTMPITVSLDQVIPPNVPEKDTKYIRHIKVQSALLTRFWGRPMFLSAVVLVPEGFDTHTEAHYPLVIFHDHFVSGFSDFRETPPDAKLKADYSERFHLAGYNRIQQEEAYKNYKDWVAPNKPRMLIIKIQHANAYYDDSYAVNSENLGPYGDAIETELIPAVEKEFRALGQGWARFVYGGSTGGWESLAVQMFYPEHYNGAFVACPDPVDFHAFMTADLYKQDNLFYEQGANKRVEQPAMRNYLGQTLISMRDNVAYEAALGDSARSGDQFDIWQAVYSPVGADGYPRPIFNKTTGTIDHTTAEYWRQHYDLNAILQRDWTKLGPKLQGKIHLYVGSDDTYFLNNAVYLMEDFLKETGTPGHGVAYDGEVKYGPRAEHCWNGDPEKPNWYSRLHYNQMYVPMILDRIAKTAPAGADVTSWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X484</accession>
    <name>E8X484_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0053</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578473.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0053"/>
    <dbReference type="EnsemblBacteria" id="ADW67144">
        <property type="protein sequence ID" value="ADW67144"/>
        <property type="gene ID" value="AciX9_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0053"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_0_1_0"/>
    <dbReference type="OMA" id="EWMKGNA"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234153" evidence="1">
        <location>
            <begin position="19"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="54"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="295" mass="31991" checksum="9F84FA2DB8233A71" modified="2011-04-05" version="1">MKRILACCVGLVVGSAMAQGGLRQQIRATAEQAKGKVSVACSLPGTLLDCDLHPDAHPPMQSVFKLPLGMAILDQVQRGRFTIDQPIRFLASDRIPNAYSPLQDEFPQADVDVPLRELLRLSVSLSDNCAADVLLRILGGPKVLQAYIDSLGIEGFHIQDDEAGLHQDVLAQYRNWFEPSAAVALLRLINDRPPFSRQNTALLTGWMKTPPDRPSRVAQALPKGIEVLHKTGTSDVSPAGVAYATNDIGLITLPDGRRLAVAVFVTDASADTATRDRVIAEISRQIYDAALQAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X499</accession>
    <name>E8X499_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysulphide reductase NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0068</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0068"/>
    <dbReference type="EnsemblBacteria" id="ADW67159">
        <property type="protein sequence ID" value="ADW67159"/>
        <property type="gene ID" value="AciX9_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0068"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_0"/>
    <dbReference type="OMA" id="WWVGIGH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="480" mass="54374" checksum="E3C3A6A05EA3FE25" modified="2011-04-05" version="1">MATKGPIHDPVLDPMIDPITGEYAVIAPGHNFKSVTQKIAGIVLTSNTPMGWFFGLQIGALVALGVVVGITWLFLKGVGIWGVTIPGAWGFAIINFVWWIGIGHAGTLISAILLLFKQTWRNSINRFAEAMTIFAVVCAGTFPLIHVGRPWLAYWLFPYPNTMNVWPQFRSPLAWDVFAVSTYATISIVFWYVGMIPDFGTLRDRATMPLAKWSYGLLSLGWRGSTRHWIRYETASLLLAGLSTPLVLSVHTVISFDFAVASLAGWHTTIFPPYFVAGAVYSGFAMVLTLAIPLRKFYHLEDFVTLRHLDNMAKVMIGTGGIVAYGYGMEVFMSWFSASHWEFFMMWNRMFGPMGWGYWILILTNIAIPLTTLWSRKLRVNVTYLFILSLIVNTGMWFERFVIVVTSLYRDYLPSSWGTYRATKWDYMIYVGTMGLFTMLFFLFVRFLPMIPMSEVRMMLPQTKVRPTGEDAEVVMNEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C7</accession>
    <name>E8X4C7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1191</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579577.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68254">
        <property type="protein sequence ID" value="ADW68254"/>
        <property type="gene ID" value="AciX9_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1191"/>
    <dbReference type="eggNOG" id="ENOG5032WYE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113748_0_0_0"/>
    <dbReference type="OMA" id="WPQFTFG"/>
    <dbReference type="OrthoDB" id="1726286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005345681" evidence="1">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21080" checksum="D6802E0D5FE98CD1" modified="2011-04-05" version="1">MKMTAIQSKRIAGGVGALMLALSASLCGAQAAYTATGPGTYVSVGATFSGFNTDYGKQKVGGGTLYVDANLYRRFGIEAEARKLTLNTTEDVKESTYLVGPKISFLRHGYRPYGKLLVGRGDFNFPFNYAKGQYFVMAPGGGIDYRVKHSRLSLRMIDFEYQVWPQFTFGAIHPYGVSAGLSFQVYSGSSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W7</accession>
    <name>E8X4W7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581917.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3603"/>
    <dbReference type="EnsemblBacteria" id="ADW70606">
        <property type="protein sequence ID" value="ADW70606"/>
        <property type="gene ID" value="AciX9_3603"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3603"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752122_0_0_0"/>
    <dbReference type="OMA" id="IERFRWF"/>
    <dbReference type="OrthoDB" id="903022at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="38958" checksum="13EBE407554E0BC4" modified="2011-04-05" version="1">MEPVTHVLTGALISRTGLNRRAAYCTAAMAIGAELPDIDTLWSIEGPLASFQHHRGITHTFVGIPFEAATVTLAFYLYHRLRKQPKTAAPARWAELFAYTLLALLSHLFLDWTNNYGLRPFFPFDPHWYAGSFVFIFEPILFLFLLIGLLAPSLFGLIGSEVGARKPPFSGRAWPTAALLAICALWLFRFNQHAEALTLAARNAPEATRVYASPHPIDPFTWHIVADTPDHYQLSTLDTHTQHFDPTEPSDTLYKPAITLPLLAAKRTGLGRIYLDWSQYPILIEAADTTDPNHPLAVVTFTDARFLYNTFLVQGRTHAPINGQVTLNMQAPDGQRVIETRMGNKIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X9</accession>
    <name>E8X4X9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578500.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0080"/>
    <dbReference type="EnsemblBacteria" id="ADW67171">
        <property type="protein sequence ID" value="ADW67171"/>
        <property type="gene ID" value="AciX9_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0080"/>
    <dbReference type="HOGENOM" id="CLU_2734372_0_0_0"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="8317" checksum="DF1C47AF8EE0E4CD" modified="2011-04-05" version="1">MDLIEQLRQRNTFLSTLETMDLLDMSRGTLCEWVRAGRISAVRKGNAYLFDPRRLADWLAERTTNMGRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z5</accession>
    <name>E8X4Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578516.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67187">
        <property type="protein sequence ID" value="ADW67187"/>
        <property type="gene ID" value="AciX9_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0100"/>
    <dbReference type="eggNOG" id="COG3600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110683_1_0_0"/>
    <dbReference type="OMA" id="VYIAHGW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="1">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17992" checksum="A7494A8F6C3DEE83" modified="2011-04-05" version="1">MPFPATAVANELLDRASAEGLSLTQINIQKLVYFAHGWNLGWSANPLILDPIEAWQYGPVVRNLYNQFRRFGSSPITGKAVEFRIDSNGKIGTTCPTLEDAYSKSVVGAVWNQYGRLQPFKLVELTHAPGSPWEAAWNAKKALIENEDIRRYFSALAQPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z8</accession>
    <name>E8X4Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0106</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578518.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0106"/>
    <dbReference type="EnsemblBacteria" id="ADW67190">
        <property type="protein sequence ID" value="ADW67190"/>
        <property type="gene ID" value="AciX9_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0106"/>
    <dbReference type="eggNOG" id="COG2433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1174081_0_0_0"/>
    <dbReference type="OrthoDB" id="768876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="3">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="76"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="4">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="26546" checksum="1C5705C34EDA070C" modified="2011-04-05" version="1">MFVAPPDLDNLDLEAAKTLLMTQHEKYTAALSSRVSEIERLVLLVEKLQRMLFGAKSEKVFCQIEQLELQLEELQAASAIEEIKRIAVLYDIEAEIRGSTADLFRTIRQARARPLLDSLFLWLETTLAKLSSTSDTAAAIRYAEDGQLEIDNNTAERALRVVALGRKNYLFCGSDAGGERAARLYSLLGSAKLNALDPELYLHHVLERIADHAINRIQDFLPWNVSINKTHTLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X538</accession>
    <name>E8X538_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578558.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0156"/>
    <dbReference type="EnsemblBacteria" id="ADW67230">
        <property type="protein sequence ID" value="ADW67230"/>
        <property type="gene ID" value="AciX9_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0156"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="CYENREW"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="38867" checksum="8426FA54837C7DAF" modified="2011-04-05" version="1">MEDLVSTWRGRRVFLTGHTGFKGGWLALWLSALGANVRGYALDPEGSPNLFDTLRLGERIEDIRGDIRNPATLEPALRDFAPEVVFHLAAQPLVRASYADPIGTYETNVLGTARVLDAVRRTPSVRAIVSVTTDKVYENRETLTPYRESDPLGGYDPYSSSKACAEIVTAAYRQSYGVPVVTARAGNVIGGGDWSSDRLLPDLVRGFLSGLPVPIRHPHAIRPWQHVLDPLHGYLLLVEQLLAGEPKSFAYNFGPSETDARPVSWIADHMTASWGAGASWRLDGAPSVHEAGYLKLDASKAHEELNWKPRLGLPTALDWLISWYRAHAAGEEMQAFTLAQIHSYEGLSGLSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X545</accession>
    <name>E8X545_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme exporter protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_1247</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579632.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1247"/>
    <dbReference type="EnsemblBacteria" id="ADW68309">
        <property type="protein sequence ID" value="ADW68309"/>
        <property type="gene ID" value="AciX9_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1247"/>
    <dbReference type="eggNOG" id="COG2386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079069_0_0_0"/>
    <dbReference type="OMA" id="VKCLAHW"/>
    <dbReference type="OrthoDB" id="1886257at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026031">
        <property type="entry name" value="Cyt_c_CcmB_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30070">
        <property type="entry name" value="PTHR30070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002764">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="224" mass="24747" checksum="D358B6B54D3C2AA0" modified="2011-04-05" version="1">MTYLRHVLTHLQKDLRLEWRSRDSVTGMLFFSLLVVVVFSMAFDPTSALSRQIAGGILWMTLLFASITALNQSWTREQRNHVMDAQRLAPSAASALFLGKALANLIFVTAVELVLAPIFTVFYDLHALGQGWLLLAVLPLGTWALVSNGTFFAALGLRTRNRELMLPLVLFPISIPALLAMVQATTAILTGESDPGLWIKLLIGYDIAFTTVCLLLFQTVLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X593</accession>
    <name>E8X593_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1295</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579680.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1295"/>
    <dbReference type="EnsemblBacteria" id="ADW68357">
        <property type="protein sequence ID" value="ADW68357"/>
        <property type="gene ID" value="AciX9_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1295"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_0"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="OrthoDB" id="762291at2"/>
    <dbReference type="UniPathway" id="UPA00529"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27276" checksum="D0650674FF259DD9" modified="2011-04-05" version="1">MIDLKGKIAVVFGLANKRSIAWAICQKLSEAGATLAICYQSERLQKDAEALAAELGAINGTAARTFACDVSSDEQIDTVFAQLKDAYGKLDILVHSIGFAPNIKNTVVQTTREDFRVAHDVSAYSLIALTRAAAPLMTDGGAILTLTYYGADKVFPNYNIMGVAKAALEAAVRYLASDLGAQKIRVNAISAGPIKTLAARGIGDFSKILNAVEERAPLHRNVDALEVGNTAAFLCSPLASGITGEIMFVDCGYNTTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M9</accession>
    <name>E8X5M9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3653"/>
    <dbReference type="EnsemblBacteria" id="ADW70656">
        <property type="protein sequence ID" value="ADW70656"/>
        <property type="gene ID" value="AciX9_3653"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3653"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903755_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="13743" checksum="B99A2F0E83FE267E" modified="2011-04-05" version="1">MVETALLMPVLLLVLVGVVDFGQAYYVEIEVGSAAQSGAAYGVLNPTDTAGMQSAALLDASDVPTMTAVATYGCECSDGTGGSVSCGVSPNCLVNMVNYIDVSTSVNFKPMMVYPLVPATMVLKGHSRMRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R9</accession>
    <name>E8X5R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572715.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70803">
        <property type="protein sequence ID" value="ADW70803"/>
        <property type="gene ID" value="AciX9_4007"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4007"/>
    <dbReference type="HOGENOM" id="CLU_018437_0_0_0"/>
    <dbReference type="OMA" id="HYEQVEW"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230259" evidence="1">
        <location>
            <begin position="21"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="328"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="672" mass="72133" checksum="8605864B8E8775A7" modified="2011-04-05" version="1">MRSLRLIYAFLFMSASLTFAQQPATSGIFVLHKFAQPIGKETYSIAASGDTYTLRSHFLFTDRSTPVSLETTFTAHTADMLPLSYAAKGKSSRLSPMDDTMTLADEALLVSANDKKTSVTPKGPWFMTDGYSPVAMQEQMMRWWLLQGKPAAFTAYPSGATVHILPAGELTVEGHLLHGYTVGGLIWGQESLWMDEAQDLAALVSIDAEFDHFEALRDAFANDLSTFISAGVKNNLSALKTLSASARMRPAKVLVITGATLEDSTGVAAVKDSVIVMSDGVITAVGSKGKIKVPRGATVLDARGKFAVPGLWDAHAHYEQVEWGPIYLAAGVTSVRDVGNEYDFITTVHDELDRKADPAVGPHLEFAGIIDGSGKDGKRARSLGVVIADTPEQAQMIVTKYKGAGAKQIKIYSSVQPEIVKAICLAAHAQGMTVTGHIPDGMTAVEGINDGMDQINHIQYLIPYLVKPTLGPDGKPIRTADVFLDVTQPKAKELLDVMKQHHTVLDPTIALFETQIHTKPMSELEPGLDHVAPQLYAALNSPAAPAARAHAVDNRWSLFPAMVGAVHAAGIPVIAGTDQAIPGYSLHREMELYVQAGFTPLEALQSATIETARAVGVEKESGSLEVGKRGDVLLLDADPMADIHNTRKVWRTVSAGAVYAPGALWESVGFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D2</accession>
    <name>E8X6D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572928.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71016">
        <property type="protein sequence ID" value="ADW71016"/>
        <property type="gene ID" value="AciX9_4240"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4240"/>
    <dbReference type="HOGENOM" id="CLU_483042_0_0_0"/>
    <dbReference type="OMA" id="AHANEMT"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230793" evidence="1">
        <location>
            <begin position="22"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="558" mass="63119" checksum="CBB5D22583CC8F5F" modified="2011-04-05" version="1">MQGLRVVAGLLLLIFCTECKAETLQDFAKEFWAWRAREQPFSADDIPRIDRPADMKIDWSPAAIERDRLELAGFEVRFARLADASAPVARLVDYRLMGSALARVHWELDIDKRWQRDPSFYVDQTLGAIYLPLLPPPPFEVERQSVLVARMRSFPETVKAAKANLTDMRQPFVDLATGDLDRIGERLGTVVTEVKPKLDAEHRRALEAALPGAVKALEEYRAWLLVQKGLKQETAIGRENYLYFLRQVALVPYTPEEMVLMSRQELDRTMAFSAYEAARNGELAPLPVFKSVDEQMQREERDEVAIRAYMESHHILTVPKWMMHYRNFEVPAYVKPLQGMGPADDLTSPTRLTQNGTSYISAPKPGPQGFFATSLDPRPIILHEGVPGHYFQESLDFANADAIRRHYYDSGPNEGIGFYSEEMMMVAGLFDQEPRTRQLIYNFMKLRSLRVGVDVKLALGEFTPAQAMDYLSKTVPMSMGTARGEVALFASAPGQAITYQIGKLQIMKLLADARLKQGSAFLLLTFHDFVWANGNVPLSLQRWELLGDASEVPALKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P7</accession>
    <name>E8X6P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3921</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582215.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71197">
        <property type="protein sequence ID" value="ADW71197"/>
        <property type="gene ID" value="AciX9_3921"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3921"/>
    <dbReference type="HOGENOM" id="CLU_147298_0_0_0"/>
    <dbReference type="OMA" id="APIEHAQ"/>
    <dbReference type="OrthoDB" id="1900723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15941" checksum="969F9E383A2BFC7C" modified="2011-04-05" version="1">MAVAVDFRVYTPVDAREDLLKRVSEAPVQHAEAVLAAFEVLEKLHEKDVLSTINGLLGAKDTVINHVAGLVSSKEMINILRLSLLAGNLVKDIDPDALHGVLKEAQGTPPSFFQIGKRMLSPDARRAMGVFGGILNVFGAALKKKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z3</accession>
    <name>E8X6Z3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein UCP028846</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582124.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71102">
        <property type="protein sequence ID" value="ADW71102"/>
        <property type="gene ID" value="AciX9_3816"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3816"/>
    <dbReference type="HOGENOM" id="CLU_023537_0_1_0"/>
    <dbReference type="OMA" id="QVFECKY"/>
    <dbReference type="OrthoDB" id="365853at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234267" evidence="1">
        <location>
            <begin position="32"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="52782" checksum="4CA1930849032B01" modified="2011-04-05" version="1">MQKTHTRREALRTIGMTAAAISAASLRPAFAAAPATLPEARPKPSDRRFQSPLVEQFLTQTSRRIADPNLAILFTNCFPNTLDTTVRPGTFEGHPDTTVITGDIDAMWLRDSSAQVWPYLPLAAKDPSLRELLEGVIRRQARCLLIDPYANAFMADLNAPPLEWSLKDKTQLKQGVGERKYELDSLCYPIRLAHGYWKQTGDTRPFDARWKQAMSLVVDTMTVQQRKHGPGPYSFQRTSPISTETLPASGFGNPINPVGLIASGFRPSDDACIFPFLIPSNLFAVTSLRQLATMSHEVLQDDALANRAEALAKEVEQALQQHAIAQTPTGTIWAYEVDGFGSQLLMDDANMPSLLGLPYLASSPDAALYARTRAFVWSPANPWFFSGTAGEGIGGPHVGQDMIWPMSQISYAITSNNDAEIRRSLQTLKTSTAGTGFMHESYSKDDAAKFTRPWFAWANTLFGELIGHLATNKPDLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X744</accession>
    <name>E8X744_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4324</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572997.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.B15"/>
    <dbReference type="EnsemblBacteria" id="ADW71278">
        <property type="protein sequence ID" value="ADW71278"/>
        <property type="gene ID" value="AciX9_4324"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4324"/>
    <dbReference type="HOGENOM" id="CLU_020336_12_3_0"/>
    <dbReference type="OMA" id="EGQIRSW"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="284" mass="31369" checksum="D9BFB29A5EEC87A9" modified="2011-04-05" version="1">MAYVVTEDGTEIFYRDLGTGKPVVLIHGWPLSGDSWDKQTNFLAEHGLRVIAYDRRGFGRSGQPWSGYDYDTLASDLNKLLEELALTEVTLVGFSMGGGEVVRYLSRYGSARVSKAVLVSAVTPYLLKTSDNPDGVDPKVFEEIEENLRKDRPAFLNEFGPKFYGRSVVHHTVSEPVLEWTQSMALTGSLRSTLQTAKSWSSTDFREEMKSITIPVLVIHGTSDNTVPIDASGRRSVKILPNAALTEYDGEPHGLFLTAADRLNEELLQFVGGPREPISTPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X747</accession>
    <name>E8X747_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71281">
        <property type="protein sequence ID" value="ADW71281"/>
        <property type="gene ID" value="AciX9_4328"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4328"/>
    <dbReference type="HOGENOM" id="CLU_067304_0_0_0"/>
    <dbReference type="OMA" id="WRNWSQN"/>
    <dbReference type="OrthoDB" id="1284694at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34600" checksum="2E55099322563A05" modified="2011-04-05" version="1">MMETSPDALVKLVPAPLRKPADVMLSHIQHGTFQRSMSLLVFGTSMVSGMEVAYEHYRGGYSNPVMYSPVILSGVLSIAGVAGFFSRRMAKTFLRCTSWITLADGLIGFGFHVRGIGRKPGGWRMPIVNLVMGPPVFAPLLFGTSAYLGVIASYLQREEDHGWKGRTIEARTALRKPDFRDDIRVGRFQKHLCVVTAIGTLASGAEAWYSHYKNNFKYKVQWSPIILTPLLAGAALASIPSKRVANTLLPVAAGMAMLNGVIGTGYHIRGILRRSGGSKKPLYNILYGPPIFAPMLFAACGMLGMMAYLMRRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A8</accession>
    <name>E8X7A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71342">
        <property type="protein sequence ID" value="ADW71342"/>
        <property type="gene ID" value="AciX9_4391"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4391"/>
    <dbReference type="HOGENOM" id="CLU_2752163_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="8215" checksum="18561F62DF17187C" modified="2011-04-05" version="1">MMKLSRKNRLKASWTCPQCGEEILINQFRLSADHPGCIVCPRVDCANPFPWKRQNRGRLWPKQSAYNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G9</accession>
    <name>E8X7G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugative relaxase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573122.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71403">
        <property type="protein sequence ID" value="ADW71403"/>
        <property type="gene ID" value="AciX9_4457"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4457"/>
    <dbReference type="HOGENOM" id="CLU_001748_0_2_0"/>
    <dbReference type="OMA" id="NGYAVEG"/>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014059">
        <property type="entry name" value="Conjug_relaxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02686">
        <property type="entry name" value="relax_trwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113837" checksum="1431CB47B93E6FC3" modified="2011-04-05" version="1">MLTISKPLNAGQAQTYHSKEFTSPDQNYWQQGDVNLGEWQGKLAETFGLSGYIDAGQFARLSEGRHPVTGEQLVKHRTSKEYITADGTTVKPVEHRAGWDATFSAPKSVSLTALVGGDDRVREAHRAAVTVALDELQHYTQARIGGNNAAETTGKFIVAKFEHDTARPVDGYAAPQLHTHAVVFNMTQRDNGDTRALQERGMFDTQQFATAIYQSELTFRLRNLGYEIEAGRSGAPEIKGYTHAYLEASSPRSQQIREYLESTGFQGPAAAQIAAHDTRDKKEIHSTAEVIAAHYKVAAAHGHQAESVIAEARDRQRFQPLERVPDAPGRAKEAVSYAKSRGFEREAVSDERLLMRDALRRGMGDITYPEIRRNFDQRLSTGEFRSVDATKHATGRSFTTPETIAMERSAVNSLRLGQDAVEPIMQIEAARKQATSKPQLNEGQRKAIEEILTSRDRVHGLQGLAGTGKTTSLAVIREGAERNGYAVEGFAPTSKAAGQLRESGISADTLQGFLARGGGEQHTGDSASRHLYMLDESSLASTRQMRDFLEKIGPQDRVLVIGDTRQHQGVEAGKPFEQMQDAGMRTTLLDKIVRQREPELLAAVERLSQNDTAAGVLMLQRQGRVTQVEDRQERIAVIAKEYARQPENTIIVSPDNISRRDLNAAVRSELQEAGIVERTSHFLPTLIPRSELTGADRQWAAQYRPGDVIHYNAGSKELNLPRGSYAAVTSVDPDANRITVRREDGTETAYDPKRLKGVSTYQEIGREFSQGDRIQFTAPSKVLGVANRELATIERITDGVVTTRMDGANPRSVTFDSAVMKHFDHGYAVTSQSSQGITAERVLVNMDTRAHPELINTRFAYVAVSRASHDAQIYTNDAENLAQRLSHDVTKSSAVDFRQPTYQITPQKEPTLNQAAEHSQPERIHTPAEHDRHYTPLNRELHPDDAKHFGWKAEAGTVQSYQHSETRRHIHIDGPSGQFYDQQKNPISKIEALDRATGSGNHHAKEPAQIQEAAQLRRMDNNIGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M4</accession>
    <name>E8X7M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid encoded RepA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4517</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573177.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4517"/>
    <dbReference type="EnsemblBacteria" id="ADW71458">
        <property type="protein sequence ID" value="ADW71458"/>
        <property type="gene ID" value="AciX9_4517"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4517"/>
    <dbReference type="eggNOG" id="ENOG50316EB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051492_1_0_0"/>
    <dbReference type="OMA" id="RRTEIPW"/>
    <dbReference type="OrthoDB" id="1074108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006881">
        <property type="entry name" value="RepA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04796">
        <property type="entry name" value="RepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="34431" checksum="BC80663405567DB5" modified="2011-04-05" version="1">MPRKDPDASKSSFFLDKLLDAAVDIKQNPEAAERVYMARHLVQCTLPHSDPGNVNIWRRRNGNVTLSIRPHIGKDDKALYPYGSIPRLLLFWMVTEATRTKSRRITLGDSLPDFMREIGLNPRNGSGERSDVARLKEQMTRLFTAQINVEQAEEAHEMNVYMPVTSKTEFWWAFKTSADRSLWDSWIELGEDFFKMVTASPVPVDMRALRALKRSPLALDLYAWLTYTVFAANKNKANRIVPWKGLHDQMGGEYARTRDFRSKTLEAIKKIKLVYPALVIESTDEYLIVHPAKTAIESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P0</accession>
    <name>E8X7P0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4537</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71474">
        <property type="protein sequence ID" value="ADW71474"/>
        <property type="gene ID" value="AciX9_4537"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4537"/>
    <dbReference type="HOGENOM" id="CLU_2342809_0_0_0"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="10327" checksum="6727B4373FFC0A7E" modified="2011-04-05" version="1">MVPIEVEERNRAQASDRDKDRAFLSQWSSEDYPACHVGMGLLSRLAESSPGAYELALSMGFERPDHPLLKRNPMWRAFVEHMNTCGDCNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U9</accession>
    <name>E8X7U9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2383 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573252.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71533">
        <property type="protein sequence ID" value="ADW71533"/>
        <property type="gene ID" value="AciX9_4603"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4603"/>
    <dbReference type="HOGENOM" id="CLU_114531_0_0_0"/>
    <dbReference type="OMA" id="HRTWMDF"/>
    <dbReference type="OrthoDB" id="1769096at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011971">
        <property type="entry name" value="CHP02284"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019052">
        <property type="entry name" value="DUF2383"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016920">
        <property type="entry name" value="UCP029477"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09537">
        <property type="entry name" value="DUF2383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029477">
        <property type="entry name" value="UCP029477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02284">
        <property type="entry name" value="TIGR02284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2383" evidence="1">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15971" checksum="8E5752EDDA6CBADE" modified="2011-04-05" version="1">MAEGYSLVKTVVQVLNDGEKGFADLGEKLKNPETKMFFIKESAHRGEFAKELEAELALTAGDTKDIGGTASGAIHRSWADLKASLGGSDHTLLETAEQGEDAAKKAYKEALEAQDLPSAKIRELLLTQQTHIQASHDTVKAFRDSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X8</accession>
    <name>E8X7X8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conjugation TrbI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4632</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbI/VirB10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573281.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71562">
        <property type="protein sequence ID" value="ADW71562"/>
        <property type="gene ID" value="AciX9_4632"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4632"/>
    <dbReference type="HOGENOM" id="CLU_646844_0_0_0"/>
    <dbReference type="OrthoDB" id="1674599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16429">
        <property type="entry name" value="VirB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005498">
        <property type="entry name" value="T4SS_VirB10/TraB/TrbI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042217">
        <property type="entry name" value="T4SS_VirB10/TrbI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03743">
        <property type="entry name" value="TrbI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="459" mass="47897" checksum="B53EAC2FF773469E" modified="2011-04-05" version="1">MVDEHNDLSTPDHNPTVPGQPQATAPLKTSKPLVIGACVVVGIIGIANVGNLASGHAKNQPAKSALPSKPVVSDSGQVNSFQAAQARQAQHDQAELLRQQEIAAQAAILQQQQETPGPESATAPAMTPAQRQAMYGSNNPNAPQKTSGVSEAQAQAKQKALLREQQHQQALASDTVAIDFSSSAGQGTSSGKASGVLADRAEGQDVARGEAEGSPVASDEPGGVLNALSARNGAPGGSEGLQSVSDRRSTTQRDPTAAYDFDGFQGRLYRVFEGTVFEGVVTNHIDGALAGPMIVMLTTDYYSHDHQQLLFPQGTRLIGNVQSVGASGQRKLMVTFNRAICPDGFSLDLNRFTGLDPLGTTGLATSVNNHYLSSFVAAAAVGGIGGLAQVGNSGSVLDSGTQIRNGISSQTAAESEQVLNKFLSRLPVITVKEGSRARVYINQDFLVPSYAEHRVDPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB2</accession>
    <name>E8WVB2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578615.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0213"/>
    <dbReference type="EnsemblBacteria" id="ADW67287">
        <property type="protein sequence ID" value="ADW67287"/>
        <property type="gene ID" value="AciX9_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0213"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="RGGIDNQ"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230343" evidence="1">
        <location>
            <begin position="34"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1143" mass="121932" checksum="D612D8DFA0872519" modified="2011-04-05" version="1">MFHPKTHADRRNRLRALALAGALIFTGAGIAGAQTDTARIQGVVTDASGAAIPSASIIVTNVNTNAVQTITSDGSGNFVVNALPIGNYKAEVKAAGFGGASQSFTLSVSQVQALAFKLAVGSENTVVEVTDAAPLVDAGSSSLGETIEGRQVTELPLNGRNFTGLALLTPGVTRGNYGNSASGVNGDAETFRNSSSGGGSLSTNGLRPQANNFILDGIDNNESLVNTLEFFTNLDATEEFRVNTSTAPAEFGRAGGSVVQSSIKSGTNSIHGSAFEFARSSLFDANPNYQFEGAGPAAPLPFKRNTFGGSVGLPILKDKLFVFGDYQGLRESQPLNPQILTVPTALMRTGNFTQLLGQGTTNKPAFCTPAVQPSGAIYDPTTCAQFVSGGQLNVIPTARLNPAAVNYLNAYPLPNVPGTNNGTQNNYRTIRQDVRHFNTLDGRVDYNPTQKDHAFARFTYDNSDFTRTSEFAALPAGFASGANSVHGRGYAVGETHLFGPNVINELRAGYNRYTFTNDPVFSNTPISANLGIVNANRNANLGGGALIGGNNHLEYTGDYGTYAVPENTYEINDALSIVRGRHSFKLGGSGIRRDVAFFRPISGKGYFNIGGGDFTGYEPAELLAGFIDNYSIGSQSGFFGTRNYETGAFVQDDWKITQRLTLNLGVRYDIITFPVEEHNRESALDPVTGAINLAGQNGFSRSIIQNNFGNVAPRFGFSYDVYGTGKTVLRGGYGIFYFQDRGGIDNQLGQQVPYGGSVSYTAAQGYRIAFTGQAPQNTLVNTANGAAVANAPLPLPGFPNFNRLAPPPGANVFSVNTTEKTSSVQQYNLQLQQQLGARTVMTVGYVGNKATHLATGYNFNFLPGVAGRTQPRFTELTSASQVVYNANDGVSHYNSLQAQLNYRAAKGLNFTSSYTWSHNIDNTDGYLGFYAVSQLDIYNKALNKGNSGLDQRNVFVASAVYDLPFGRGQRFGSHLNRTADYVLGGWQLNSVVQAETGNPFSVVIPSYGGVYSQRADAVSLIRTPHSTTGAYFTGTFAAPTGLQGNTGRNEFYGPGFAQGDVSLFKNVSLTERVKMELRAEVFNVTNTPQFTNPDSNPTDAGAVQNAAGVNTYTANGTVSNFGRITGTREYSERQMQMAVRFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC2</accession>
    <name>E8WVC2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HI0933 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0223</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578625.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0223"/>
    <dbReference type="EnsemblBacteria" id="ADW67297">
        <property type="protein sequence ID" value="ADW67297"/>
        <property type="gene ID" value="AciX9_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0223"/>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025174_2_0_0"/>
    <dbReference type="OMA" id="RCNFTNM"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="43085" checksum="D6B1934CF09FD56D" modified="2011-04-05" version="1">MRDFDVVVLGAGAAGLMCAAEAGRRGRRVLVVDHADKVGKKILISGGGRCNFTNLGCRAENFISENPHFVRSALARFTAADFVAMVERHGIKYHEKTLGQLFCDASSREIVAMLEKECGEARVTIWTSTSVAKLGRREDGRFLVETSQGAVLAEAVVVGTGGLSIPQMGATSFGYEVAREFGLRVTTCRPGLVPFTLRPEDRERWCDLSGVSAMAEAKATDKKAPGFREKILVTHKGLSGPVVLQISSYWKEGEAVELDLAMGEKVFGGLLQKNARRDVAAVFAAVKTVLPGRWAERWVAVNAPELGDGRRDFTNAEIAEMERTMHEWRVLPAGTEGYAKAEVTTGGVDTAELDAKTMEAKKVPGLYFVGEVVDVTGWLGGYNFQWAWASGFCAGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE3</accession>
    <name>E8WVE3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine-protein phosphatase CpsB</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1329</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Capsule biogenesis; capsule polysaccharide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579714.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1329"/>
    <dbReference type="EnsemblBacteria" id="ADW68391">
        <property type="protein sequence ID" value="ADW68391"/>
        <property type="gene ID" value="AciX9_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1329"/>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_0_0"/>
    <dbReference type="OMA" id="VHPERNS"/>
    <dbReference type="OrthoDB" id="1666267at2"/>
    <dbReference type="UniPathway" id="UPA00934"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29521" checksum="19484DF055412FB8" modified="2011-04-05" version="1">MVDIHHHLLWGLDDGAKDFETSVAMAKASAADGVTEIVCTPHANGKFNFDPMVNAAKAAQLQARLDADGIKLKVGLGCDFHLSYDNILEAKENPTKFSVNGLGYLMVEIPDYGVPRGLNETFYELQLVGLTPVLTHPERNPTLQSDLPRLAEWMRGGVLVQVTGDSVTGKMGKDAEKMAHTLLSRRWVHFLATDAHNVSSRPPRLSEARDLVARKYGSEYADSLVETNPRAVFDGTRFEAQAEPLGLYEEFKDTPWWRRILDSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG7</accession>
    <name>E8WVG7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1355</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579738.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1355"/>
    <dbReference type="EnsemblBacteria" id="ADW68415">
        <property type="protein sequence ID" value="ADW68415"/>
        <property type="gene ID" value="AciX9_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1355"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_0_1_0"/>
    <dbReference type="OMA" id="AELCCFE"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="51"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="22215" checksum="3A9F5A2985745519" modified="2011-04-05" version="1">MAVAMKKQTIGDANVAPHWHAKAKEIQAYGSVIEDMPHRLSAKVRAEMVGKLNQLLADSIDLRDMYKKHHWQVSGPTFYQLHLLFDKHFEEQVELVDTIAERIQLLGGVTIAMGGDVAQISQIPKPPRGKEEVPVQISRLLEAHKIIMQQCHDIAEAADDAGDDGTNDMVVSDILRPNELQSWFIGQHLVEMPLILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR4</accession>
    <name>E8WVR4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix, AraC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2566</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580908.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2566"/>
    <dbReference type="EnsemblBacteria" id="ADW69593">
        <property type="protein sequence ID" value="ADW69593"/>
        <property type="gene ID" value="AciX9_2566"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2566"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_1_0"/>
    <dbReference type="OMA" id="ESIHFIN"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="160"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="278" mass="31201" checksum="D1A7F71264D658AF" modified="2011-04-05" version="1">MLTVQSASPSPALLPYIRTYVQREAHLGTRTLIEPVVARLGVMLEFEFAGSYEVRNYGSETVEDPNVISVIGPQGWRRSRLIIRGDIESLVVMFQPFGFHALFGVPTALLSNAGTEGHSLLGRKVSRLREQLGNLPTFAQRAKALDSFFLRQVSVPQSVDPLQRALHQLMAPETGLKVADVARQMGVGLRQLERRSLDYAGMSPKTLARIARFSHALRLRTERSLNWTQIAHAAQYHDHMHMIRDFREFAGEAPTSALLEIEPEHLIHFAMEPSSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS3</accession>
    <name>E8WVS3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580917.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2576"/>
    <dbReference type="EnsemblBacteria" id="ADW69602">
        <property type="protein sequence ID" value="ADW69602"/>
        <property type="gene ID" value="AciX9_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2576"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1218379_0_0_0"/>
    <dbReference type="OMA" id="PDHIPER"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="25701" checksum="D10EB842B1E28DE4" modified="2011-04-05" version="1">MRSREKHDHLSSSFTDLMSSLVVIFILLFLAFVHEQEERQESVKDKLLSELQQQLKEANLDQQNIKKDGDAVVIIVPEGLMNFETGKSDLKDGGKAFLAKYIPPISKMLVSDFRNDVDSLIVEGYTDRQRAAGSSEEQGEAQNLILSQERSMKVVEESLRDLSGPDHIPEREFFLDRLSASGRGEQQAIHQGGPENNPNLRRVIFRIRVRSNAMQDAAQEIKADLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY0</accession>
    <name>E8WVY0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582048.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3738"/>
    <dbReference type="EnsemblBacteria" id="ADW70739">
        <property type="protein sequence ID" value="ADW70739"/>
        <property type="gene ID" value="AciX9_3738"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3738"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="LDYGENN"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="1">
        <location>
            <begin position="503"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1098" mass="118355" checksum="A3320B6075E3B8D2" modified="2011-04-05" version="1">MMFKQAARIAIVSTVIAGAGTFAGYGYAQSATEGAIGGTVQDSTGAVVPKANIVIHNNGTNAEQTVTSDDSGFFRVIRLQPGLYTVTVNAPGFRAFKSDKVDVTVGALTDVNSTLQTGSSTDTVEVTSDTAAINTTSPDFAGLIDQQTLQNLPVSNYRWSAYAALTPGVVVDGSGFGLLSFRGQSTLLNNVTIDGADDNQAYFSEERGRTRAGYSTAKASIQEFQVNTSNYSTEYGRSAGGVVNSVTKSGTNQFHGDLYFDDRDAEWGASNNYALQTVQNAAGAFVSTHIKPTDKRKQYGGAIGGPIWKDKVFFFFAGDRFDHNFPAVAAASVPATLYAVPDATLPAGKVCGTTGGTAPSTLDASVCTLQTNLGLPTYAAAATDYINGTAGLNSMLGVVPRKGLQDIFFPKVDWQINAKNHFNAELNRLRWVSPAGIQTGLVVFDGASSFGNDYVRDTFLISKLDSLITNNLSNEVRYQYGRDFEFEFNQTPTPYEQTNLVGPTIGGYTNPMGLPASVSITNIFTFGTPNFLNRAALPDERRWQIADTANYNRGKHNIKFGVDYVHTNDIVNNLFSGFGAYSYSTLTNYFTDLYLSQSAANTASSRYKYTSFTQGFGIPGLEFQTGDYAFFAEDNWKATKRLSLTYGIRYEYEQLPTPLSNLVNPALPQTGNHPSSKTNFGPRVGFAYDVFGSGKTILRGGYGEFFARILNGTIYNSLISTGLAAGQYTASFTPGQAGSPTFPRIIAAGSLSVPPNVVYFDPNFKTPEIHQADLTVEQDLGHNTVMSVTWLGSYGRRLANFTDTNLPTPTTQNYTVVDTSGKGPLAPGSIFTSKFYAKLPNTAVSPCLSQRPNCAYGAISDIFSGVNSNYEGLVGQINHRFSNHVSFSANYTWSHALDYGENNQTATTANNLLDPQNLRAEYGNSNQNVPNRFVINGVVTSPWKFTNTALKYLANDFEVAPSYALQSGLPYSMTSSGSLTSGFGGINGSNGTFRIPGIERNGFEQPKTNVLDLRISKRFAVTERVKLELLGESFNIVNHQNVTSVNALGYTVGSTGTLTFNTATASPTVSQFGARTATNSSNFQFAPRQLQLAARLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD9</accession>
    <name>E8WWD9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EH_Signature domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580918.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2577"/>
    <dbReference type="EnsemblBacteria" id="ADW69603">
        <property type="protein sequence ID" value="ADW69603"/>
        <property type="gene ID" value="AciX9_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2577"/>
    <dbReference type="HOGENOM" id="CLU_615060_0_0_0"/>
    <dbReference type="OMA" id="KGANEDF"/>
    <dbReference type="OrthoDB" id="865236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028943">
        <property type="entry name" value="EH_Signature_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15611">
        <property type="entry name" value="EH_Signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH_Signature" evidence="1">
        <location>
            <begin position="33"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="445" mass="50535" checksum="843C797A41282DB8" modified="2011-04-05" version="1">MRLLEALQGLAALPRDISLTSLSKNCDPVFELRPLDAAVTKMKAQAASTRPPDPARIEKLIARFHAEKQNLDRFEPREIRLLAWNNQMLLNARFRSQLAERVRSRAVKPNLLILSQVYFGSWGTHAEHELFEQMLRILADQQAGFTPLLQRYKEKATSIFSASADVFLSRQISVEQASLTETLALWGVPTTTPLASAVLTAYVNHILTEISSGRVGQLDDLLATLQLPLVQMSTFQAGAGTLILSPHADKNDSFRKRIEAFVLDSPRLGDPRLPHNLPKWNGVDAAALRKFRTWRATKDLVFFFRSVLPEGRDPHGRKDFWLRYVDQVVDSVVALCPTDLQRLHTSLSLERVHHCRIQENQSISCFLMRFKGANEDFIVAEFSNVGKARIFYYGRFLERIGDINRSEFRLRELKSEEGLAISFSHMNNWQSKVRSTLAQIGIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI8</accession>
    <name>E8WWI8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PAAR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2627</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2627"/>
    <dbReference type="EnsemblBacteria" id="ADW69652">
        <property type="protein sequence ID" value="ADW69652"/>
        <property type="gene ID" value="AciX9_2627"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2627"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650149_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="43020" checksum="07B7B227E30CEF1C" modified="2011-04-05" version="1">MPPAARVTDMHTCPMVTVLVPHVGGPILPPGAPTVLIGFLPAATVTNMVTCVGPPDIIVKGSAGVFINFLPAARMGDMTAHGGVIILGEPTVMIGEIGSPSPGAGGLGGIVAGLAAAIVKDFNKAIASVYAAGTGAIDALTAKTIQLAAQFLAGKKSTRAFLLDHSPHDTTQLPYDGKVIGSGCQPTEPGTVATAPGVRPAKCPDPSKTIPKVYFANGINTKFAGDGASMCATMQNIANQTCAEVVGIYGATEGMLPDLDQAVDEISKTSDSKQVSTLTDLVYGAASKDPPDPLNLIVHSRGGLATQEALDHAKSAMLAGDMSPAQVSQALSKVNISAYGTAVQGWPVGPVYSKLNNVADPVPAAMKGAQSAFQSATNADNDPTPTGYINEPQLNPINAHSLDSIYAKYMPQAPGPRDCNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI9</accession>
    <name>E8WWI9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2628</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2628"/>
    <dbReference type="EnsemblBacteria" id="ADW69653">
        <property type="protein sequence ID" value="ADW69653"/>
        <property type="gene ID" value="AciX9_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2628"/>
    <dbReference type="HOGENOM" id="CLU_1545462_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19681" checksum="EE7F3C2C1DC44B61" modified="2011-04-05" version="1">MTLPLSSTLTHGDAYRYVAAWAAFDHDSLAHISDNGKEFFGTMGGIDFQYAESDHILHVWGLIMPGAAPFLTTKAEIKQQIDQTAHDHPEETAGAVFDIRTLPWNKQSIAKLEPRLYLRLDLADTSIPTDQAMKRFKNLRDAAYVWHRQKMLEILNDWWAKHPEAAKKYSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM9</accession>
    <name>E8WWM9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tail Collar domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3774</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582082.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3774"/>
    <dbReference type="EnsemblBacteria" id="ADW70774">
        <property type="protein sequence ID" value="ADW70774"/>
        <property type="gene ID" value="AciX9_3774"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3774"/>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782481_0_0_0"/>
    <dbReference type="OrthoDB" id="1837650at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233436" evidence="2">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Collar" evidence="3">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="33518" checksum="98FB63F819E52438" modified="2011-04-05" version="1">MKPFPSLVLAAALLPATGLAQTEVQADKRSPATPSTNVIYACVTDFADFARIVKAPKDCHKEEKLVEWNIKGIAGPEGPPGPQGPIGLPGLTGAKGATGTTGPVGPAGVAGAKGPAGPTGIAGPAGAIGPIGPAGAKGATGANGPVGPAGVAGATGSIGPAGVAGPTGPAGTAGAKGATGANGAIGPAGPNGATGAIGPIGPSGPAGTIGATGPAGPLGPAGVQGPTGPTGPAGAQGPQGTPGSTTLPAPLQALSTLLTVVPSEQYNAQFLDGNGGACTLGDMVLSTNRYYGGNFFPADGSLYQISQNTALFSILGTRFGGDGVHTFAVPNLAAAAPSGLYYSICFKGIFPPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX6</accession>
    <name>E8WWX6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ordered locus">AciX9_1484</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579857.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1484"/>
    <dbReference type="EnsemblBacteria" id="ADW68537">
        <property type="protein sequence ID" value="ADW68537"/>
        <property type="gene ID" value="AciX9_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1484"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_4_0_0"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19435" checksum="F4C009C1B2B9C08D" modified="2011-04-05" version="1">MPITLLPSVPRRRDMRPYLLLLAVVVIVLDRWSKIWIGTHIPSGHYITVIPNVFRLSHVFNTGAAFSLFAELSPAIVRNTLIGFSVIAVLVVLGMIWRVGRVYSLTGIALALILGGAIGNLYDRIKLKYVVDFLEVKIVHYHWPDFNVADSCIVIGACLLLLEIFRNQPVGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX07</accession>
    <name>E8WX07_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1515</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579887.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1515"/>
    <dbReference type="EnsemblBacteria" id="ADW68568">
        <property type="protein sequence ID" value="ADW68568"/>
        <property type="gene ID" value="AciX9_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1515"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_14_3_0"/>
    <dbReference type="OMA" id="NQEAVCR"/>
    <dbReference type="OrthoDB" id="100725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="218"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="595"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="747"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="819" mass="89898" checksum="467934FB00B5FC04" modified="2011-04-05" version="1">MNLSTLLHETFGFPAFRANQEAVCRAATDGRDVLLVMPTGAGKSLCYQLPAIARGGTGLVISPLIALMDDQASKLTAAGLKVARIHSGLSREDSRQACRDYLDGKLQFLFIAPERMRVTGFPEMLARRKPSLIAIDEAHCISAWGHDFRPDYRTLGDYLPQLRPAPIIALTATATPTVQRDIVTQLNLQQPALFIHGFRRDNLHIEVMELSKPQRTEFITKFLADPTRRPAIVYAPSRKAAEELAEKLNGTFKAAAYHAGLDPATRERVQTQFLSGNMEVVVATIAFGMGIDKANVRTVVHAALPASVEAYYQEIGRAGRDGDPSRTILLYSYADRKMHDFFLERDYPVATDLARVARVLNEDFQSPEELRHRLKMDADTFAKSVEKLAAQSAAAYDMGGNVRATGNHAWQSGYELQVQHRRTQIDSIMQYAETQQCRMTALIRHFGDTADGHRPCGHCDFCAPNATTAQTFAEPSAQDDRHLRTILRALDSSSKATGRLHTDLALTSDRKQFDGLLDGLARAGLITLSAETFTAADGKVIPYKKAAITHEGRELSSSDPLGVVLRELSAAPTKSKSCASTPAKRKAEEEATNYTPAQKTLEAALRNWRKEEAAKTGKPAFIVFTDASLRALVQHAPQTIPQLLQVPGIGPDKAERFGPALCAICRGTEIPGDYGTPAPKPAKRKAPDSKLETRDSELFNAKPSPISAPNRELRTENPQHPHAPIIPHPPIRAAIPPRAESPGETLTPDQQALEQRLRDWRKAESERMGLPQFFVLGTTALRSIVLQRPSTLTQLQGIHGIGPDKLDRFGADILAVCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB3</accession>
    <name>E8WXB3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0374</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0374"/>
    <dbReference type="EnsemblBacteria" id="ADW67446">
        <property type="protein sequence ID" value="ADW67446"/>
        <property type="gene ID" value="AciX9_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0374"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106747_0_0_0"/>
    <dbReference type="OMA" id="HIWSHEA"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230034" description="Thioredoxin-like_fold domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="60"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="235" mass="25943" checksum="F43CA5AA5AA477D4" modified="2011-04-05" version="1">MRPIPMTFKTRLIHAAAVAALALPFALTPAAHAQESAPPGHADPFRDTSVIKLPAGQRAAIFEFEDLECPACAHAAPIVYQAIEHYHIPFIRHDFPLQMHIWSRDAAITARYLQDKVSPELADQFRRDVFAHQISIASKDDLSNYTRQWFGAHHQQVPFVMDPAGRFAAEVQGDYTLGERLGVQHTPTIVVAGPHGWVEVNDVTQLYTTIDNVLAQSPATPAPAHNMHKVSAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH6</accession>
    <name>E8WXH6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ordered locus">AciX9_0437</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578837.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0437"/>
    <dbReference type="EnsemblBacteria" id="ADW67509">
        <property type="protein sequence ID" value="ADW67509"/>
        <property type="gene ID" value="AciX9_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0437"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_0"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="216"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="516" mass="57179" checksum="AB05A8E2B7CD6E2F" modified="2011-04-05" version="1">MAIPEVKAAPAAPVKTQKPERKPDPCIVVIFGASGDLTKRKLLPALYHLEQAGLLPKEISVVGVARRPLEATFAPDMKEGIIAGGGVDEKEAALAPFIEHVQYHAMNFDDDAGYAGLNELLSSIDKKNGTKGNRLFYLATAPEYFADIINALGKHEMNKPAKDKPGSWVRTIVEKPFGHDLESARKLNDDVNKVFDEDQVFRIDHYLGKETVQNILVFRFANGIFENVWNRNYIDHVEITAAESIGIEGRGPFYETAGALRDVVQNHVMELLSFVAMEPPVSFEASAVRAEKVKVWKSIQPIHPADTVRGQYGPSTVDGKQVVGYRQEDRVHPRSQTETYAALRLEIENWRWAGVPFYIRAGKRMAKRVTEITITFKQPPLSIFKDAEGKGAEGIRSNVVSMRIQPDEGITLRFGAKLPGPNMSISPVNMNFSYAESFGASSANGYERLLLDAMLGDATLFAHRDGVEATWALITPILEDWAKNPIKDLPNYPAGTWGPPASDAMLKADGRKWRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ6</accession>
    <name>E8WXQ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2727</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581066.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2727"/>
    <dbReference type="EnsemblBacteria" id="ADW69751">
        <property type="protein sequence ID" value="ADW69751"/>
        <property type="gene ID" value="AciX9_2727"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2727"/>
    <dbReference type="eggNOG" id="COG3128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106663_0_0_0"/>
    <dbReference type="OMA" id="FPPLFNC"/>
    <dbReference type="OrthoDB" id="1139586at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00657">
        <property type="entry name" value="Hydroxyl_YbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041097">
        <property type="entry name" value="PKHD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023550">
        <property type="entry name" value="PKHD_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41536">
        <property type="entry name" value="PTHR41536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18331">
        <property type="entry name" value="PKHD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25165" checksum="72034A66CD82EF0E" modified="2011-04-05" version="1">MLLAIEDVLTKELVNEARRVLAGAEWVDGRVTAGYQASEVKRNAQVKEGTAEANAVGEMVLTGLARSPRFMSAALPLRVFPPMFNSYAGGQTFGTHVDTAIRQVSTTGQRIRTDLSATLFLTEPDEYDGGELVVEDSYGEHKVKLPAGHMVLYPATSLHRVEPVTRGNRVSSFFWIQSMVRHDAQRTLLFDLDSSIQRLAGVEGDEVKASAVQLTGVYHNLLRQWSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS7</accession>
    <name>E8WXS7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2748</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581087.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2748"/>
    <dbReference type="EnsemblBacteria" id="ADW69772">
        <property type="protein sequence ID" value="ADW69772"/>
        <property type="gene ID" value="AciX9_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2748"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753899_0_0_0"/>
    <dbReference type="OMA" id="DIAPRHD"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="287"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="367" mass="37506" checksum="7F6C06768580553A" modified="2011-04-05" version="1">MSTPLRSETVTQPQPQEQQFKHFGVMNTGGQSKSSLFTSVTLNIVLAIVAIIIGAAAKKTIALRAKENLTYVAPVPVPEPKPIVKIIPPPPPPKLPPVKTIEPKILKPEVKLPDVPKPLEMKPVEKPLPAVAPAPPKVVVAAAAPKPVAVNLARSASVANNDPHPAAVSLGTANNPLHSDRPAVAAVDLGSRGLAGMPARTTGGGPPASSVNLGSGQPGGAMNGTGSRGVQGVKFGVTNGTPGGTGNGVGNRPAVVALGHAPETPQTQQARAEHPPVRTGPQVLFKPRPVYTAEATSMHLEGTVSVRIRVSSNAAVSVIGVTNGLGHGLDESAVHAIQATRFKPAVDASGNPVDWEGVVNISFQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ6</accession>
    <name>E8WXZ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578863.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0463"/>
    <dbReference type="EnsemblBacteria" id="ADW67535">
        <property type="protein sequence ID" value="ADW67535"/>
        <property type="gene ID" value="AciX9_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0463"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057068_0_0_0"/>
    <dbReference type="OMA" id="FFAKQWM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="30627" checksum="73D8E9D52BF89770" modified="2011-04-05" version="1">MNGRRLTTAFLIALLISGLCTWVLSRKMGTHAAERVADQHYVAASRPLQSGEQLKPDSMELVNWPASNPIAGGFLKPEDLVGRSVLYPVEKDQPLTDKLLSTAGSGPGLAARIPAGMRAISLKSDEIMGVAGFLSPGSHLDVLVTYRTDKNPEPVTLTVLQDAEVLAAGQKIQPDPDGKPVTATVVTLLLTPEDAQRAVLASSQGAIHFILRSGSDKVHVQESAMAMSQLSGAPAPTVPTGLTAPVVQKSSLVTHAPKNLGELEKQQSKPAFVIETISGDKQSTESFGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY38</accession>
    <name>E8WY38_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0505</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67577">
        <property type="protein sequence ID" value="ADW67577"/>
        <property type="gene ID" value="AciX9_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0505"/>
    <dbReference type="eggNOG" id="ENOG502ZV97">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2770113_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7932" checksum="19B9432521C21084" modified="2011-04-05" version="1">MRCEQVFRANDQIGNRYELCRLTARMTRRLHFVSGNTHDAIEDAFVRVGQPLPLVAELIQPVLPVAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY44</accession>
    <name>E8WY44_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1618</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1618"/>
    <dbReference type="EnsemblBacteria" id="ADW68671">
        <property type="protein sequence ID" value="ADW68671"/>
        <property type="gene ID" value="AciX9_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1618"/>
    <dbReference type="eggNOG" id="COG1138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015041_3_0_0"/>
    <dbReference type="OMA" id="SYWGMQL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003568">
        <property type="entry name" value="Cyt_c_biogenesis_CcmF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01411">
        <property type="entry name" value="CCMFBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="105"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CcmF_C" evidence="9">
        <location>
            <begin position="332"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="691" mass="76042" checksum="716778EC74194F6F" modified="2011-04-05" version="1">MTPHPMPEFGSFCLLLALMLCIYTFVAGAIALWRSRAQATGSAGLAVSSKLQETSRRAGISSFVAVGCAAFALIWAAFTNDYSVSYVMHHTNRELSSVYKFSALWSGQEGSLLLWTMLLASYGFVLRVRHKVDVRLSAFASVILAAVQVFFLTLLNFAAPPFAIEPGPLALDGFGLNPLLQYPEMVIHPPMLYLGYVGFTVPFAFALGALMMRYPGEKWIHITRRWTMVTWMFLTCGIFLGAHWAYSVLGWGGYWGWDPVENASLMPWLTGTAFLHSVMMQEKRGMMKSWNVWLIFSTFLLTLLGTLLTRAGLVSSVHAFAQSSIGYWFTSFMAIVLAVCLFTYFMQRDHLKSENRLESLVSRESSFLFNNMILLVACLTVLVGTLFPVLSEYVEGTKTTMGAPYYNRVNIPIGLFLLLLTGIGPLLAWRSTSLRSIRRNFILPGIAFGVSLVGLMIGGIRPWSAGDDWQAQTFSLLAFSLAAGVVTAILSEFLRGANVVRVQNGTNLVMAAATLMRRNTRRYGGYLVHFGIVVMFIGIAGGAFNQSREKEMGFGDSVSIGPYKLTCQSYTQDSNANYDTDFALLDVTRGGKAVTQLAPELRFYHASQTTSTVVALHSTAISDLYVIFMGRNPDTSRPIIKVFLNPLIAWIWIGVLIVVAGTLFALAPSAVARRRETATAAVPVGAEVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY60</accession>
    <name>E8WY60_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1635"/>
    <dbReference type="ESTHER" id="acism-e8wy60">
        <property type="family name" value="Est9X"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68687">
        <property type="protein sequence ID" value="ADW68687"/>
        <property type="gene ID" value="AciX9_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1635"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_10_1_0"/>
    <dbReference type="OMA" id="LIHGGCW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="29335" checksum="C672FEF2BC7533B9" modified="2011-04-05" version="1">MPISLLDRKPPPADHRIPYGPHPLQFGDLRLPTTHPAPVVVFLHGGWWKAAYDLEYGGHLCAALKSRGIATWSLEYRRVGDVGGGWPGTFQDVALGFDHLTELAMTYPLDLGRVVVAGHSAGGHLAYWLAGRPHVPVGSPVAGRGLGMKGVVGLAGAVDLRMTIDLAGWFTFAHDKDEVISFMGGGQGEVPERYRAGNPGDLLPLNVPQMLLQGTEDDQIPPQLPVRWAERGRKMGEAVAVQMIPGADHFDVCDPESKAWPTVLAAIEKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY85</accession>
    <name>E8WY85_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1662</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580031.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1662"/>
    <dbReference type="EnsemblBacteria" id="ADW68712">
        <property type="protein sequence ID" value="ADW68712"/>
        <property type="gene ID" value="AciX9_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1662"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_0"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="418"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="531" mass="57945" checksum="D6D87874AFE9E401" modified="2011-04-05" version="1">MNREEMIERVKARTTPWDIVIIGGGAVGAGVAVDAASRGLDVLLVEREDFGKGTSSRATKLVHGGVRYLEQGNVSLVMEALKERGLLLQNAPHLVHDLPFVVPNYSWWEAPFYGIGMKIYDLLAGKYGFGKSRVLSLAETLERLPTIQQEGLRGGVLYHDGQFDDTRLLTHLIVTAVDHGATVLNYASAVEMLKDSQDFLNAVIIEDRESGNRHTVGAKVVVNATGIFTDDTRRLANLVAEPMVSPSQGIHLVFDRSFLAGDSAIMVPHTSDGRVLFAIPWHDRTLVGTTDTPIDKPSYEPHALEEEIAFVLDTAAQYLSRPPTREDVLSIYVGIRPLVKAAGSDNSKTSALSRDHTIQIDASGLITIVGGKWTTYRHMAEDCVNHAITLGDLPDTPCVTFNLHIHGYDQNASRLGSLAVYGTDAAAIQQLIAAQPELGQLLHPDLPYIAAEIVWAARHEMSRSLDDALARRTRALLLNARATIAIAPKVAHLLAIELKRDATWEQAQVETFTKLATQYVLQPASAATVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA5</accession>
    <name>E8WYA5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580051.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68732">
        <property type="protein sequence ID" value="ADW68732"/>
        <property type="gene ID" value="AciX9_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1682"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_0"/>
    <dbReference type="OMA" id="DGGFCRY"/>
    <dbReference type="OrthoDB" id="854580at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="702" mass="76919" checksum="EA73C9C8C9AE213F" modified="2011-04-05" version="1">MSLAKARSAYLRSAIHQPVQWHEWSPEAFARAQAEDKPILLDIGAVWCHWCHVMDRESYENAETARLINEHFIAIKVDRDERPDVDARYQAAVAAISGQGGWPLTAFLTPQGQPYFGGTYFPPLDQHGRPGLRRVLMTMAEAFQNKREEVMDTAGSVIAAIEHNESFDGSASNPGTELVDKLIASALQQFDRRNGGFGSQPKFPNSGALDLLIDAASRVGSQDGIAAAARATAAFTLEKMSKGGIYDHLAGGFHRYSVDERWVVPHFEKMSYDNSELLKNYVHAYQTFVEPECARIAREIIRWVEEVMSDRELGGFYASQDADANLDDDGDYFTWTLAEARAALTKKELAVTAPFYDIGELGDMHHNPQKNTLHVDQPLETVAKAAGVSLDQASALLQTSLPKLYAARKTRPTPYIDKTLYTAWNAMMISAHLEAARVLADPATRLFALKTLDRVLSTAWHEGSLDHVIAYGESSEPTDPIPGILDDYAFTGHAALDAWEATGHISYFNSALALADAAITKFYDEEKGGFFDTETPAPGELRLGALSTRRKPLQDSPTPAGNPVAAALLLRLEALTGREDFKQMAKATLECFAAVVEHFGLYAATFGLALQRLLLPPIQVVIVGEDSVADRLERAALGRYAVNKTVVRLTPSQLTTLPPSLAQTLPHFLTTLGSYAAVCTGFTCRPPVNTPEALAEILLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK2</accession>
    <name>E8WYK2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0528</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578928.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0528"/>
    <dbReference type="EnsemblBacteria" id="ADW67600">
        <property type="protein sequence ID" value="ADW67600"/>
        <property type="gene ID" value="AciX9_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0528"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_0_0_0"/>
    <dbReference type="OMA" id="IRIKSNV"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233495" evidence="5">
        <location>
            <begin position="21"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="485" mass="51706" checksum="6CA8D7F0E2D2A6D0" modified="2011-04-05" version="1">MRFGLIGLAGLMTVGGVAVAQDTRFVKEPVIPASCVVLGAKLQAVKDHLADADEGKLDTERIQKAMDGCKTGQAVELKTMGESNAFLTGPLELRSGVTLLVDEGVTLYGSRDPKVYEMRLPDAKPGDPIKCGTSLPRPGQFGQEAGMAQVAGLRRGGCRPLISATNVTDAAIMGDGTIDGRGYAKLLGKDFSWWEMARKAEPKDDIYFSTRLLVASHADGLILYRVTLHNSPNFHVAVNQTNGFTAWGVHLLTPVDKTLDARNTDGIDPGSSTNVTIAHSWIDNGDDNIAIKANVKHMSVLDNHFYTGHGMSIGSEATGDEFILVDGLTEDHTTSGIRIKSNVTRGGYDHDLTYKNICMRGVKNPIAISPYYTNQTTEGFVDPGYTGTKIPDYKKIRLENIYATTPGDVLIAGLNDDHRTEITLKGVQVAGITAAQTHLAFVDIALEGAGSNLNLTGGKGVKVTGVAEGKGGSTDACANVFVPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS5</accession>
    <name>E8WYS5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_1713</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580080.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1713"/>
    <dbReference type="EnsemblBacteria" id="ADW68761">
        <property type="protein sequence ID" value="ADW68761"/>
        <property type="gene ID" value="AciX9_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1713"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009270_0_0_0"/>
    <dbReference type="OMA" id="QSFIVQA"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="13"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="532"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128524" checksum="7085C21F1BF0BFB1" modified="2011-04-05" version="1">MPNLTLVPKPTPAADDTPARQQALDIQQSWIVQAPAGSGKTGLLIQRFLKLLAADNVQDPAQVLAITFTRKATVEMRDRVLTQLQSAHTGTPPRNDFDRLTLPLAQAVIEKDRRQGWNLLDSPHRLAIRTIDSVCVDIARSLPILSGAAGALTPTEDSAPLHAEAARRTLMLLGSEDKTLSTAIETVLLHRDANLADVENLIADMLQVRDQWGELIPLAADELTDTYLDTIVLPKLDKALDQAICRGLTRLSKALPPPVLQSLCELAADMGNAEGYKGNPSPIAICAGRYPIPGEKSEHLDHWRALIHLLVAPSSQTFRKSLNVNHIGFMISAAHKKQLAQLIEQVADDPDLCKLLCSVNALPPIHYPADQWPITKALFRVLSRALVELQLVFAARTQCDFAELGLLARAALRNTSAVSDLAQATGQNLQHLLVDEMQDTSTSQYELIQLLTQHWDGSSQTVFLVGDPKQSIYLFRQARVERFVNTMHSRTLGDVPLGVLNLTANFRSQSTLVENFNQDFGLLFPTLASGNPSEVSYTPAIPRRPATQHAAREWHPTPIPYTDDTNTRTTQTTRQRRQTATEIRDLAAAWLARDHTARLAVLVRNRSHLIEVVAAFKQSPAVPFRAIQIEPLRERQEILDLLTLTRALLHPADRTAWLALLRTPWCGLTLTDLHLLTGADDPTLARTSIIHLIATRGDLLSDDGIARLEPVWQILSAALAQRGRLPISQWIERTWRSFNAPAFSTQEELANIDQYLTLLDQLESPGNTLDLTLLDQRLSKLYAAPAVHPGAVDLMTMHGAKGLEWDAVFVPALERTGANNRSRLLSWLEVDGTPDLDDDTIAHGILAPIQSKGTASQQLNTWMRSIESAREAAERKRLFYVACTRAREELHLFASPVAKQDGTLSIPPASLLASAWPAAEDHFHPPAAQLIVMPTQPQILDSLAAAAAPRTILRIPLSPIELIPTPEPTQPQTLFDRPEGSFASRAFGNTVHAFLDQLAARIAAGDTPAQLTTELPQWSPRIAQLLRASGLPPTTIDRFAPRVLTALYNTLTDPDGQWLLAAHPNATTESALVSWDETRTSIRMDRTFLAGDSPQTTASTHQWIIDYKTADLGGRTESTFLAEEKQNYAPQLEAYAATFPADTPIRLALYYPMLPKLIWWPTTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY0</accession>
    <name>E8WYY0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Uricase</fullName>
            <ecNumber evidence="5 8">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2872</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 8">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581210.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2872"/>
    <dbReference type="EnsemblBacteria" id="ADW69895">
        <property type="protein sequence ID" value="ADW69895"/>
        <property type="gene ID" value="AciX9_2872"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2872"/>
    <dbReference type="eggNOG" id="COG3648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_0"/>
    <dbReference type="OMA" id="THRWTRM"/>
    <dbReference type="OrthoDB" id="1150949at2"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="287" mass="32348" checksum="B56EA5F94A59C7F3" modified="2011-04-05" version="1">MAELTDAKFEIVANRYGKSKVRLLKVTRAEGRSDVHEWTVQVLLRGDFETAHTVGDNSKIVTTDTMKNTVYSLARWSSATTMEEFAEELIEHLLRRNEQVSSVRVHIEAALWKRLTVDGKEHPDTFMRGSNEVQTATVEQARAGEKKFIAGFANLQLLKTANSAFSGFQRDELTTLPETRDRVFGTAVDAKWTYSGPVEFAAMRKAAREVMLKVFADHMSESVQHTLYAMADAALEAVAEITEIELAMPNKHCLLVDLSKFGQDNPNQIFVPTDEPHGYIEARVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ7</accession>
    <name>E8WYZ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2889</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581227.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2889"/>
    <dbReference type="EnsemblBacteria" id="ADW69912">
        <property type="protein sequence ID" value="ADW69912"/>
        <property type="gene ID" value="AciX9_2889"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2889"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_2_0_0"/>
    <dbReference type="OMA" id="LFGAAHW"/>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="20261" checksum="2F2DE72EA23735DB" modified="2011-04-05" version="1">MNGVVAIILAAGASTRMGSPKQIALLNGEPLLSRAVRTALEAECTPLVVLGANAEEVAAVCDLASAQTVFNPQWESGMAASIAVGIRKASETYYAAIIMTCDQPSVTPAHLRQLIHKGERLGRPIASAYAGRKGVPAFFPADHFALLACLSGDLGARDLLAEAQAIDLPLGELDIDTPEKLIQAQRVFVTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ50</accession>
    <name>E8WZ50_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, WecB/TagA/CpsF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0581</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0581"/>
    <dbReference type="EnsemblBacteria" id="ADW67652">
        <property type="protein sequence ID" value="ADW67652"/>
        <property type="gene ID" value="AciX9_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0581"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_2_0_0"/>
    <dbReference type="OMA" id="NMNGTDF"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="31727" checksum="9E91CCE51D8ACF72" modified="2011-04-05" version="1">MRDESQDLVNVLGVHIAPVDMDGALTRIADALCNATRGYVCMTGVHGVMEHYRHPELREVFADSLLTAPDGMPTVWVGHLQGHAGTRQITGPDLMLQVLGRSEFAGYTHFFYGGKPGVAEELRATLEGRLPGVRVIGTCTPPFRELTVEEEKEFIQMIDELRPDIIWVGISTPKQERFMHRMSPRLRTTLMFGVGAAFDFHTGRIQDCPLWIKRAGLQWLDRLLQDPKALWKRYLRNNPAFVWHIVLQLTGLRTYPGAARTAARKPSVQGSSTLLRKVESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ80</accession>
    <name>E8WZ80_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0611</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E8WZ80"/>
    <dbReference type="STRING" id="1198114.AciX9_0611"/>
    <dbReference type="EnsemblBacteria" id="ADW67682">
        <property type="protein sequence ID" value="ADW67682"/>
        <property type="gene ID" value="AciX9_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0611"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_1_0"/>
    <dbReference type="OMA" id="HANDSWA"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230479" evidence="1">
        <location>
            <begin position="20"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="505" mass="53928" checksum="A616A7C7C52DD582" modified="2011-04-05" version="1">MLKRLLPLILLTTTMAAQSFQLEETTIAKTQAALTSHKTTCRQLTQAYLTRIAHYDPTLNTVVTLNPQALADADALDKEFAQTHKLRPLQGIVVMVKDNYDTKDLQTTGGSLAMKGFIPTEDAFMVAKLRAAGAIIIAKSNMAEWAFSPYLTESSIAGITRNPYDPTRVPAGSSGGTGASVAANLAEVGLGTDTGNSIRGPASHNDLVGIRPTIGLTSRAGIIPLSFTNDVGGPLARTVADAAAVLAAVQGYDPADPITKLSEGKAPKDYTASLDPKGLKGARIGVVRKYIETPTTDPEIKALTEKAIADLKSQGAEIIDNFTLPDLDRGPQKPTCGGFEYDLNQYLAAHPNAPCKTLAEIIDSGLYLGSIADRLKHAALPAAEATTAHCPDTYHDPRKIAFRDAITQSMDAQHLDALIYPTWSNPPRKVGDLKSPAGDNSQIISPMTGFPAITVPMGFTVNQTLPAGLTFVGRSFSEPELIKLAYAYEQATHHRQPPPQFPKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ99</accession>
    <name>E8WZ99_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unclassified family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579029.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67701">
        <property type="protein sequence ID" value="ADW67701"/>
        <property type="gene ID" value="AciX9_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0630"/>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044348_1_2_0"/>
    <dbReference type="OMA" id="MCDENLA"/>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="130"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="35600" checksum="F26F754027E262AF" modified="2011-04-05" version="1">MSSPKTLQQAIIFYSEPKNCIAEMVAQRWPDGVVICPTCGRNDVSWLAAQNKWQCKSRHAKRQFSAKVGTIFEDSPLGLDKWLMATWMLSNCKNGVSSYEIARNIGVTQKSAWFMLHRIRLAMTETDDTQLGGAGSAPIEVDETFVGGKVKNMHKSKRVKGLNYSAGNGKAIVLGMLERGGKVRAGVVENRKLPSMNGPVAANVAAGSHLISDEHAVYPFIAAQNAYYHEIIKHVEGYVNGHIHTNGIENFWSCLKRGLTGTYISVEPIHLDRYVDEQVFRFNNRHKQTDATRFAKVLSQVTGKRLTYAEVTGKVHETAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE3</accession>
    <name>E8WZE3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1783</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580150.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1783"/>
    <dbReference type="EnsemblBacteria" id="ADW68831">
        <property type="protein sequence ID" value="ADW68831"/>
        <property type="gene ID" value="AciX9_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1783"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="MIEISCK"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25717" checksum="5438E3153BECC943" modified="2011-04-05" version="1">MLSDTLLAVRLKHRMGTLELDVAFEAGGGWTVLFGPSGSGKSTVLRAVAGFVRPDEGRISVRTGTRQRVLVDTGTRRFLPAHKRGLRYAGQAAMLFPKMTVRENLMQAHVGPGREAWLESAIRHFGLGELERKMPGELSGGQRQMVSVVRAAVGEGEILLLDEPFSGLDGRLRDSLIGRLREWLGKTPVVSVTHDVGEAFLLGAEVVRMSEGRVVRQGAVEDVLGEERERLLGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE9</accession>
    <name>E8WZE9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase WecB/TagA/CpsF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1789</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580156.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1789"/>
    <dbReference type="EnsemblBacteria" id="ADW68837">
        <property type="protein sequence ID" value="ADW68837"/>
        <property type="gene ID" value="AciX9_1789"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1789"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080209_0_0_0"/>
    <dbReference type="OMA" id="PAIHCIG"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="29207" checksum="B55962C5951BF77F" modified="2011-04-05" version="1">METTASQPLAYSSHFRKILGVNFFGGQAKEAVEMMRSGGLLVVPAAPALKDLSTNSGYRDALVNADLCITDSAYMVLIWNALEHDRLYRLSGLEYLRALLQEPDVQESGNTLWIMASPQSARMNLSWLKSEGIDIPERNVYMAPIYGSEIEDPALIQRILQIRPQHIVITVGGGTQERLGLYLKRQLDYLPAIHCIGAAIAFLSGDQVHIPEWVDRFYIGWLFRCISEPKRYLPRYWGARKLLPLMVRYRSELPPLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ3</accession>
    <name>E8WZJ3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ordered locus">AciX9_2944</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2944"/>
    <dbReference type="EnsemblBacteria" id="ADW69967">
        <property type="protein sequence ID" value="ADW69967"/>
        <property type="gene ID" value="AciX9_2944"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2944"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_2_0"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="13374" checksum="715EC0F6363E7D69" modified="2011-04-05" version="1">MPVRIHEKPKFKIKIKRNDQVVVIAGKDKGKKGRVLRVLADKNRILVEGVMMMKKHVKPDPQKNIKGGIAEKEATIHLSNVMLADSEGKPTRVGTRMEGDKKVRFAKTNDAVLPVKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK6</accession>
    <name>E8WZK6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ordered locus">AciX9_0917</name>
        <name evidence="11" type="ordered locus">AciX9_2957</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579308.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0917"/>
    <dbReference type="EnsemblBacteria" id="ADW67984">
        <property type="protein sequence ID" value="ADW67984"/>
        <property type="gene ID" value="AciX9_0917"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69980">
        <property type="protein sequence ID" value="ADW69980"/>
        <property type="gene ID" value="AciX9_2957"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0917"/>
    <dbReference type="KEGG" id="acm:AciX9_2957"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_0"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="395" mass="43218" checksum="DFCBF140CD42856B" modified="2011-04-05" version="1">MGKEKFDRSKPHVNIGTVGHIDHGKTTLTAAITKVLSKHNPNNTFRSFDTIDNAPEERERGITIATSHVEYETANRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQVGVPYIVVFLNKCDAVEDEELIELVEMEVRELLSKYDYPGDDTPIIRGSALGALNGEPQWEAKIDELMAAVDQYIPQPERAINLPFLMPIEDIFSISGRGTVVTGRIERGKVKVGEACEIVGFGDTQATVCTGVEMFKKQLDEGLAGDNAGLLLRGVAKEAVQRGMVLAKPGSIKPHTEFKGEVYVLSKEEGGRHTPFFNGYRPQFYFRTTDVTGSAKLPEGTEMCMPGDNIQLEITLHTPVAMEKGLRFAIREGGRTVGAGTISEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR7</accession>
    <name>E8WZR7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0657</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579056.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0657"/>
    <dbReference type="EnsemblBacteria" id="ADW67728">
        <property type="protein sequence ID" value="ADW67728"/>
        <property type="gene ID" value="AciX9_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0657"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014755_0_0_0"/>
    <dbReference type="OrthoDB" id="1000523at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230112" evidence="2">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="29589" checksum="02FB66108A9CA752" modified="2011-04-05" version="1">MPSFHRIAAALAVLLSITAAHAQSTDLNGIAHVAIRVHDLPATQAFYEKLGFEHAFELKNKDGVVYETFIKINDTQFLELYSPTEKDPQVGFLHLCFEGADLNALHDSYVSRGLTPNAVRKAGAGNLLFTLAGPAQPTFPQNIEYTQYQPNSLHTNDTGKHLGADRIADRMTSVSLAMVDPAAARAYYLDKLHFLPVAGSQSLLSLPGTSGQTVEIVPATLAPHARFTLQTASLKQAAKRLKQASLPATKSSHTLTVNDPDGNQIVLSDTAHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX9</accession>
    <name>E8WZX9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
            <ecNumber evidence="5">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0720</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579116.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0720"/>
    <dbReference type="EnsemblBacteria" id="ADW67790">
        <property type="protein sequence ID" value="ADW67790"/>
        <property type="gene ID" value="AciX9_0720"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0720"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_0"/>
    <dbReference type="OMA" id="MIDYQDT"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="5 6">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="24321" checksum="30F12EEA1CD6B04F" modified="2011-04-05" version="1">MPESRIPRILELAPNFEAKSTHGTIRLTDYTTRGKWVMLFSHPSDFTPVCSTEFVEFARRQADWDRLNVQLIGVSIDSLQSHIAWVLDLERIFNVKIEFPLVVDLDQKVSAAYGLVHEAVSDTATVRSVFVIDPKGLIRALLYYPMQLGRNVDELIRIFEALQVADTNGVSCPANWQPGQPVVVPAPATQADAVKRAAGVAGMDVQTWYLSTKQIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY5</accession>
    <name>E8WZY5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1834</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1834"/>
    <dbReference type="EnsemblBacteria" id="ADW68881">
        <property type="protein sequence ID" value="ADW68881"/>
        <property type="gene ID" value="AciX9_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1834"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815764_0_0_0"/>
    <dbReference type="OMA" id="FRNACER"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="37026" checksum="9CE04C56CE07FD0A" modified="2011-04-05" version="1">MLTGILLMAVLCAPKSPAQNAPPPSLAKAQENFSAKHYKEAATQSAWLAEHALDPHLRLTAQLLEAKSLVNLPDLPAAEAVLDRYILATPRSSEALYLLGFVLQRENKPKESLAIYTRAAAISPPQPNDLKLVALDYVLLNDYPDAILWLKRSLDGDPANAEAWYFLGRAKMQGGDFVEAEKAFRRALTLAPNDSRALDNLGLSLAAQNRTEDAAQAYKDAIASQPSDHATSEQPFLNLGTLLNDENHSSEALPLLQRAAEIAPRSVRCQEELSRAYLATGNQPEAIASLQRALALDGSNPSLHFRLGQLYRKAGMTEKATAEIQLSSRLYGTHSTAQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY9</accession>
    <name>E8WZY9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1838</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1838"/>
    <dbReference type="EnsemblBacteria" id="ADW68885">
        <property type="protein sequence ID" value="ADW68885"/>
        <property type="gene ID" value="AciX9_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1838"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695922_0_0_0"/>
    <dbReference type="OMA" id="PTLWELV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233543" evidence="3">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="396" mass="43797" checksum="68F2B0878F1D0887" modified="2011-04-05" version="1">MMVTKILRVAWICGTWLLATGMSRAQSPEVQLAFQHGASFLHEGRNADAEREFRSAIRLDPKLPEAYLDLGLVLGREGKMAEAIETIRKALELNSHLESANMFLGIFQYQTGQTDAAISSLHQEIALNPKNEEALSWLGIAELASGRPELAVGPLDAASELSPDDLNLLEYRGRAHSQVAQASYARMAKLQPDAWQVHKVRAELFSADNKDREAIAEYQAALVHESRNPDLYEGLGDAFRHLNELEQAQKAYLQELTLSPQNPIAMYNLGSTDIDLGDYAGGIPLLTAMLKVYRSSPKAEYYLGRGLAENGQNAQAAAMLERSSQGDLNGEVGKRSYYELARLYRKMHKPEDAQRALAAYDHLRERDEKQKADTLSDWRKLSGSGGSPASTQSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X000</accession>
    <name>E8X000_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580215.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1850"/>
    <dbReference type="EnsemblBacteria" id="ADW68896">
        <property type="protein sequence ID" value="ADW68896"/>
        <property type="gene ID" value="AciX9_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1850"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426163_0_0_0"/>
    <dbReference type="OrthoDB" id="1919192at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="190" mass="20305" checksum="C1FCB21292DE69C0" modified="2011-04-05" version="1">MGALRTNVLLVEDDVALRTLFSIILARSGYAVRSAEDGFAALVEMRRDVPDILLSDLYMEGMSGFELLSVVRRRFPGIQVVAMSSAYSGVAVPDGIAADAFYAKGANPGALLDIVADVKELLSGAPSRENSGLVPVWLARDTADGVKERFVLLSCTECLRGFAQVAANGALKVHSAECVYCGQPIRYAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X036</accession>
    <name>E8X036_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1886</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1886"/>
    <dbReference type="EnsemblBacteria" id="ADW68932">
        <property type="protein sequence ID" value="ADW68932"/>
        <property type="gene ID" value="AciX9_1886"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1886"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_4_0"/>
    <dbReference type="OMA" id="HKAFGIH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="492" mass="52078" checksum="FDC11B5A0C293C38" modified="2011-04-05" version="1">MDTSAPQFVRGMGLFSATAIVMGSMIGSGIFIVSADMSRTLGSPALLIAAWLVTAAMTIIGALSYGELAAMMPKAGGQYVYLRESLGPLWGFLYGWTLFLVIQTGTIAAVGVAFGKFLGVFFPGVSQTRWIWHLGSGNVGLNTANLTAIVMITLLTLLNTFGVKLGAAVQNIFTSAKVLALLAVVGVGFVAKNAAAMATNFGAGWHNFWVGAGLGTMHSIAVGSFWPGTHDAVAIVGALTAVAVVQVGSLFSSDSWNNVTFTAGEIENPKRNLPLSLVLGTGVVLLLYIACNFVYLSVLPLAAIQNAPQDRVATAVMEAAFGGIGAKLMAGAILISTFGCVNGLVLAGARVYYAMSKDGLFFKGVGKLSEKSGVPVNSLWVQWGWTCLLCLSGSYGQLLDYVIFAVLIFYILTIVGLFVLRRTQPDAPRPYKAIGYPVLPALYIVMATWVSVVLLRYKPQYTWPGLILVLLGVPVYLVWRRSSGGNVTVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X064</accession>
    <name>E8X064_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3024"/>
    <dbReference type="EnsemblBacteria" id="ADW70045">
        <property type="protein sequence ID" value="ADW70045"/>
        <property type="gene ID" value="AciX9_3024"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3024"/>
    <dbReference type="eggNOG" id="ENOG5033DQ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192345_0_0_0"/>
    <dbReference type="OrthoDB" id="2060153at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7820" checksum="8527F2A0A9F2FE0D" modified="2011-04-05" version="1">MAASQPKTQKPQGNHGADAESRRKRQELELQREFILSQRTSSPHRRSALANALADVEEKLTELGWTLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F8</accession>
    <name>E8X0F8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0752</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0752"/>
    <dbReference type="EnsemblBacteria" id="ADW67822">
        <property type="protein sequence ID" value="ADW67822"/>
        <property type="gene ID" value="AciX9_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0752"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_0"/>
    <dbReference type="OMA" id="AVQMPYI"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="396"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="770"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="831" mass="90884" checksum="E021FB40D3A57786" modified="2011-04-05" version="1">MNTLFTNDEQEQDEQRKAARATPSGPKWKLALNHAKLILDQILLRGPDYPSRKIATKAMFWTLLSMSALFGAMSGLMVVYSIDLPQMEELAKYRPNTTTELLDVNGKVIGSFALERRVVVPYSDFPVVLRDAIISIEDKSFERNWGINLVRAVGAAYADMHTHSRAQGSSTLTMQLARNLFLSAQKTYWRKLQEIFLTVQIERRFSKNQIFELYANQIYLGHGRYGFEAGSEFYFSKHVKDLTLPEAALLAALPKGPEQYSPIRNPERALKRRNLVLSEMEHDGKITPERAAEAEATPLGLKIEVAPNSEAPYFVEEVRRQLEREYGVDEVHGAGLRVYTTLNMDLQRVANKAVLDGTARYERRHGWKGNLQNVIAGGLDPATYKHPDWNQTAVPGDYVHGMVTAVTPKRVDVKLGNRTTALTPADWVWTQQASSSFLKVGDLIYVRIEPVADATLPVLPSTPLHATLQQDSGVQGSMMAVDNANGEVLAMVGGRDFYLSQFNRATQSVRQVGSSFKPYVFTAALEAGTKITDIVVDAPTSFPTPGGWYTPRDYEAGFAGAMTVQSAFEQSRNIPALKLAAKVGIRTVIAVAHRFGITSEIPPFLPIAIGAADITLAEQVGAYSVFPNDGIRIAPHYIRKVTQPDGVPLDAKKPAVTEVISVEIARQMMTLLKGVVLRGTAATAAGELHHPLGGKTGTTNDFTDAWFIGFSPSVTCGTWIGFDNRQTLGKGEQGAKAALPMWIDFMKAAIVGKDDEQFPSAGAPKKVLAVQVTHGDDDSDKQPDKDDDSADPDSATPKAAVPIVRQPPVTDTTPLTPTPQAPPAAPAPQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q5</accession>
    <name>E8X0Q5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage prohead protease, HK97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1960"/>
    <dbReference type="EnsemblBacteria" id="ADW69006">
        <property type="protein sequence ID" value="ADW69006"/>
        <property type="gene ID" value="AciX9_1960"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1960"/>
    <dbReference type="eggNOG" id="COG3740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110185_0_0_0"/>
    <dbReference type="OMA" id="VCTFPAY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006433">
        <property type="entry name" value="Prohead_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04586">
        <property type="entry name" value="Peptidase_S78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01543">
        <property type="entry name" value="proheadase_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="27018" checksum="A0CB025B09AF5AB3" modified="2011-04-05" version="1">MQPKSPLEAMEVRTAPLKEVRVETNATGGHTVSGYAIVFNSESVDLGGFIEVVAPTALNRTLTGNPDVLCLRDHKQEFLLGRTTAGTLNLAPDDTGLHFTCNLPNTTVANDLAESLRRGDIDSCSFGFSVVSDAWTTDGNGNDRRTLLDLDLFEISIVSFPAYESTSASLRTAPPEVRARVAKRTADEGADDDNVCPCTCPECLSGTCNNCSVDGCSLDQCSCDNDERSRTLHQKRSLLALRLLEMQITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X198</accession>
    <name>E8X198_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580370.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69052">
        <property type="protein sequence ID" value="ADW69052"/>
        <property type="gene ID" value="AciX9_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2007"/>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035706_0_0_0"/>
    <dbReference type="OMA" id="MHTIARS"/>
    <dbReference type="OrthoDB" id="1780129at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="221"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="43643" checksum="1A01B71660C28B6D" modified="2011-04-05" version="1">MREGRRFGLSAEHKADIWRRWKLGESLKEIGRAFNKDHGSIQFMLSKHGGIAPAVRERSQRALTLVEREEISRGLASGSSIREIAKGLERPASTVSREVVRNGGRSVYRASEADQRAWRSALRPKACRLARHRKLRLVVAGKLIRDWSPEQISGWLKRRYPNNESMRVSHETIYRSLFIQARGVLKKELVQHLRSKRQIRRSVHAKAAGQSRGQIVDAISISERPAEINDRAIPGHWEGDLLSGSGNSHIATLVERHSRFTILVKVPSKDTATVVAALSRQVRKLPASLRRSLTWDRGLEMAKHKSFTVATKVDVYFCDPQSPWQRGTNENTNGLLRQYFPRKTDLSGYSQADLNKVALRLNQRPRKTLDFDTPASKLQASVASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A7</accession>
    <name>E8X1A7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2016</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69061">
        <property type="protein sequence ID" value="ADW69061"/>
        <property type="gene ID" value="AciX9_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2016"/>
    <dbReference type="HOGENOM" id="CLU_2553495_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="9272" checksum="997D10D554C203A0" modified="2011-04-05" version="1">MGLMERVADLLKSRAYRAFCIHCIGKALDVDRIVTVYEVLGQLDYMARATAMGFMRGFGKCSVCGRQRVVVFYKPNDCQIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A9</accession>
    <name>E8X1A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2018</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580381.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69063">
        <property type="protein sequence ID" value="ADW69063"/>
        <property type="gene ID" value="AciX9_2018"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2018"/>
    <dbReference type="HOGENOM" id="CLU_1347338_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21415" checksum="5FBDB91249798919" modified="2011-04-05" version="1">MEIITISGSGIVESIPINGPFTCNQPLYGQAGYGSVFLDVTQTYIPSSMIQAITPAGTTITPPTGAAYVHLLLYDQGNGAGATPNDLNSFMMAAGTTQLAYVDFNFATTDLLASVGNNSVTEALQLVRDFGMQQLNLFNVDTVQVGALKYGVLDTTVGNFRTSALFPVFGSTQMISNTQFPGSGPANGYGAAFFDFTKTYIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C4</accession>
    <name>E8X1C4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2033</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580395.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2033"/>
    <dbReference type="EnsemblBacteria" id="ADW69078">
        <property type="protein sequence ID" value="ADW69078"/>
        <property type="gene ID" value="AciX9_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2033"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_9_0"/>
    <dbReference type="OMA" id="DEYAFAN"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17650" checksum="3EF4CF5214B61C22" modified="2011-04-05" version="1">MPITIRDFNPAISTDQPAFQSLNEAWITKHFRIEPADAAALAHPKEKYLDQGGHIYLAFQNETPVGCCALILITPGQYEISKMAVTPAAQGQGLGRQLLTHTIAQAWKLNATRLYIETNSALAPAVHLYESLGFRPVPAERLTKSLYTRANVFLELFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I3</accession>
    <name>E8X1I3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3207</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3207"/>
    <dbReference type="EnsemblBacteria" id="ADW70218">
        <property type="protein sequence ID" value="ADW70218"/>
        <property type="gene ID" value="AciX9_3207"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3207"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292988_0_0_0"/>
    <dbReference type="OMA" id="HRATPEC"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="199" mass="22223" checksum="3FC82B882C155551" modified="2011-04-05" version="1">MLQAEKAAGKLLPEYHRATPECPHPERWHMYDSMTAEAEVLEFLRTLITTLKPELVVETGSFLGVSTLWMAEGMRTNGFGKIVSCEFDPLVYKKAKEKIAASGLENFIELRNESSLEMHVSGTIDILFSDSDTDIRAAEVRRFLPQIRSTGLILMHDASSHMKVVRNAAFTLEAEGLVSCIFLPTPRGLVLAQKREGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J8</accession>
    <name>E8X1J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacid CoA-transferase, B subunit</fullName>
            <ecNumber evidence="4">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3222</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3222"/>
    <dbReference type="EnsemblBacteria" id="ADW70233">
        <property type="protein sequence ID" value="ADW70233"/>
        <property type="gene ID" value="AciX9_3222"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3222"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_0"/>
    <dbReference type="OMA" id="VAMMHTN"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="23444" checksum="A322280A931BD3A3" modified="2011-04-05" version="1">MSPLMNAKELIARRIAREFRDGFYVNLGIGLPTLVAAYVPAGIEVIFQSENGMLGIGPPPTPQQEDPDLINAGKQTVTALPGTSFFDSAESFAMIRGGHMDMSILGAMQVSSAGDLANWSIPGKMIKGMGGAMDLVASARRVLVAMEHNAKDGTPKILDQCTLPLTGKAVVHDIVTELGWIKVTPQGLTLIEIAEGLTPDEVQAKTGAKLNISSDLRTMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N1</accession>
    <name>E8X1N1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0882</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579274.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0882"/>
    <dbReference type="EnsemblBacteria" id="ADW67950">
        <property type="protein sequence ID" value="ADW67950"/>
        <property type="gene ID" value="AciX9_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0882"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="DWTGNIR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="141"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="464" mass="52157" checksum="5611B9B0140A7627" modified="2011-04-05" version="1">MNHVLIVDDEAEIRISLQSILEEEGYLVTSAGTAGEAMTLLRDAVFDVVLLDIWLPDRDGLEALGEIRTMDSASVPEVVIISGHGTIEAAVRATKLGAYDFLEKPLSLARTLMVLKNAMQTRQMRVDNAEFARQLSAKSTVTGASVPMKALRQQIKLMAPTNGRVLIYGESGTGKELIGRAMHAESLRKERPFVELNCAAIPEDYIETELFGYRNGASPHKNSNAPNEKRGTFERADGGTLFLDEVGDMSLKTQAKVLRALDEQRFLPVGASHPVHVDVRVIAATNKDLEEEISRGNFREDLFYRLNVIPFFVPPLRDRKEDLPLLVKEFLAEFGAQYGRPRVEMTDDALQALKQYHWPGNVRELRNLIERVLILNPKVQRIERKHLPMLVYRESREAKAPTSGQPRGEEFATLLEAREAYERDYILKKIDECHGNMSRAAEALGLERSHLYRKLKAIGVSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N5</accession>
    <name>E8X1N5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0886</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0886"/>
    <dbReference type="EnsemblBacteria" id="ADW67954">
        <property type="protein sequence ID" value="ADW67954"/>
        <property type="gene ID" value="AciX9_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0886"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_2_1_0"/>
    <dbReference type="OMA" id="FANERFK"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="37781" checksum="A795FAAEB6A98ECC" modified="2011-04-05" version="1">MQPVVNPDHTVTFHYVAPEATTALVSIDVSKTPFPMTKDAAGVWTYTTAVLPPEIYGYHFEVDGRMALDPHSVTIKASYTSVGDGFLVPGSPAQPWETTAVPHGTVHVHTFTTKVVQGLEANQDFVYVYTPPGYDAKAKTKYPVLYLLHGWSDTAGGWSTIGQANYILDNLIAAGKAKPMIVVMPLGYGDMSFVRSGGGVWQDLAQIDHNVALFQQSLLTEVIPQVEANYKVAPGRDNRAIAGLSMGGLESVSVGLKNTEMFGWVGGFSSAVHMLKPEALAGLDAKKANLHLLWIACGTSDDLIEPNRRLVTELKAAGMPVTAVETSGAHTWLVWRDNLVTFAPLLFQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N7</accession>
    <name>E8X1N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579280.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0888"/>
    <dbReference type="EnsemblBacteria" id="ADW67956">
        <property type="protein sequence ID" value="ADW67956"/>
        <property type="gene ID" value="AciX9_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0888"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_0"/>
    <dbReference type="OMA" id="SDQRHPY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="457" mass="51177" checksum="8A58C73FB2D6BC68" modified="2011-04-05" version="1">MAPENPASPTRKPWPPGPSVPRRILDGSLFAIDSPAFYKQNAAHFGDVVSFRTPNGFRQFQFNDPKRIEDMLVRDAPHHLRGVVLRRARGILGDGLLTSEEPLHLRQRRLAAPAFHRTRIAGYGREIVRLTQEMTAAWPTSGGIEAHAEMVRLTLRITSRCLLGSDVHASIQTFVDSMATFNDYLPFALLPGAAFLERFPIGPMPGMKRALKALDDLIFGIIAQRRASGILGDDLLGMLMEATDESGQMNDRQVRDEALTILLAGHETTANALTFCLWLAAKHTTHQQHLAEVIKDVCGDRPPEAADFPNLKPLEMFFAESMRLYPPAWVVARTATQDYTMRTGEFIPKGAHLIASQLVVHHDERWWPNPTHFDPLRFTDEAKATRPKFAYFPFGGGARYCIGEGFAWTEGVLMLATVLQHHRLTLPDPTQQTVPITPKFTIRPTREVPILVEPRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S1</accession>
    <name>E8X1S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0923</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579314.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0923"/>
    <dbReference type="EnsemblBacteria" id="ADW67990">
        <property type="protein sequence ID" value="ADW67990"/>
        <property type="gene ID" value="AciX9_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0923"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_1_1_0"/>
    <dbReference type="OMA" id="CEFGCPY"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="6">
        <location>
            <begin position="61"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="40121" checksum="8F399A7118F6EEF1" modified="2011-04-05" version="1">MAKINDNGSELFPILQPSTLTGLAKLAAEAEHVGDGHLIEFRAMEVRSVLNKSVSKRRLSLAYSINPYRGCEFGCRYCYARYTHEFLAAKNRPADTPDYRDPELFERLIFLKENAAWLLEQELRKIDPAEEIALGTATDPYQPIERTARITRSLLEVFARKSGYRLGIISKSQLILRDIDLLSEISKRNTLVLHTTITTPDAKLARVLEPRAPRPDLRFAAVKALREAGLTVGILCSPLLPGITDNEKALDAMARRAAEAGASFFSAQPLFLKSCSRPTFLSFVQEHFPHLSANYAKRFAGRDFASAEYRGELSHMVKQVCERYGLAPRSTDALLTRDVGNPKKPVQNVGAVVQERLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U3</accession>
    <name>E8X1U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2059</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2059"/>
    <dbReference type="EnsemblBacteria" id="ADW69104">
        <property type="protein sequence ID" value="ADW69104"/>
        <property type="gene ID" value="AciX9_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2059"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403220_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="682" mass="74251" checksum="393ECB184E1C8597" modified="2011-04-05" version="1">MGSAWSSELVEWVRGSAVGAGFDLCGVAGAPASGESEGVLTAERFSEWVAGGRAGEMEYLKRRDEAGELLRRSARVAMPWVRSVVVCALNYHAEGPLSVDAAAKGAGWIGRYAWSGGEDGEPVDYHDDLMRRLKVVEAGLVARVSSETLQTKCYVDTGPLLERDFAARAGVGWVGKNTCVINQGVGSWLLLGVIVCSLEVETEAAALVAADRCGSCTRCIEACPTGALVASREMDASLCIAYLTIEKKGAIAEELREKMGRQVFGCDICQDVCPWNRKAPVGDHVGFRARGELVNPSLDWLGGMSADEFRRWFKGSPLERTKRHRVQRNVAIAMGNSGDESFVPKLMEWAGGEDAVLAESAGWALRRLGLLASRQRAWMLSEDVKKSEAEPEVKPIEAVKPTVREDGAWPQVKALAMYMASTEVHTYAFSVAANVILSLFPFIVLLLTLAQKVFHSPAMVAVVGDLLRTILPNNQDFIVRNMTSLVHPHGSTRVFSVVMLLITSTGVFLPLEVALNNVWGVKENRNYLQNQMVSLGLAAAVGALAMASVALATGQQRITTWIFFGHTDNIFFNFLAGGVLKICAVVMSVLLFFLIYWVLPHRKIPAMAVLPTAIVIGLSWEVAKYLYVLALPHLDFESVYGPFKVSVGLMMWAFLSGLMLLAGAHFSATRYTLRLAREAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V2</accession>
    <name>E8X1V2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2068"/>
    <dbReference type="EnsemblBacteria" id="ADW69113">
        <property type="protein sequence ID" value="ADW69113"/>
        <property type="gene ID" value="AciX9_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2068"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049171_2_0_0"/>
    <dbReference type="OMA" id="KIWEEND"/>
    <dbReference type="OrthoDB" id="922127at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233593" description="Carb-bd_dom_fam9 domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="55"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="30051" checksum="EFD872FAD4CD64A5" modified="2011-04-05" version="1">MSWLQPSFCSCTKVVATACLLMTGLISTHSAAQATTDQPQPLSYSCQYTKTPPTVDGRLNDPAWQSAAWTSDFVDIEGPAKDKPRYRTRMKMLWDDNYLYIAAELQEPEVKATLTKHDSVIFKDNDFELFLKPLPETQSYYEFEINALNTGWDLFLNKPYREGGKADNSWDIEGLKTAVAVNGTLNNPNDKDVGWTVEIAIPLTAFQPRQDVPHPTLGTIWRVNFSRVEWKAGQPKEDNWVWTPQGLINMHVPDRWGYLRFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z6</accession>
    <name>E8X1Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2113"/>
    <dbReference type="EnsemblBacteria" id="ADW69157">
        <property type="protein sequence ID" value="ADW69157"/>
        <property type="gene ID" value="AciX9_2113"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2113"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047236_0_0_0"/>
    <dbReference type="OMA" id="DTREAIF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230576" evidence="1">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="48175" checksum="713FC1812E1D580C" modified="2011-04-05" version="1">MTLESRVAGILLSLSVSACAQVTLPAGTPLPVAIPVHLPMLAGETLRSELLYPVYVDNKLVLPAHTIVLGLVLSLNPDHGRRVYARFSADFTPFRTPVVEFTSILLKNGSSLPLATSAATDGAPIFRLTPGPPKRGGIIRQQYQVVKASVRNQALFYTAPGRGDRLKQLLYNQLPYHPQRIDQGTAWTVTTTAPLELPADSAMLALVAVTPEAENNHLPDFFDRLTAPDKLAQEAPEERPKWLIQAYLDEPISSATSHVGEPVKATVAVPIFNADGSLAVPEGAVLTGTVTQAQPARRFSHTGKLRFTFTTLTLPGAAPKNVRTTMAAADAKTPQQLAMDSEGNVAPEPTNKVAPLIYAALAALPLHHDRDADAGEQFGKNALASNSLGLIGFIIGTASRQAAVSGAIGAYGAAVSMYRAYFARGKETAFARNTRIVLKTEATQVTRLKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B7</accession>
    <name>E8X2B7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0982</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579373.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0982"/>
    <dbReference type="EnsemblBacteria" id="ADW68049">
        <property type="protein sequence ID" value="ADW68049"/>
        <property type="gene ID" value="AciX9_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0982"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_1_2_0"/>
    <dbReference type="OMA" id="LAPFKGQ"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="20218" checksum="934D917895CF5F13" modified="2011-04-05" version="1">MSTLFEIPLKTLSGEDSNLAPYAGHVLLIVNTASKCGLTPQYEGLEQLYSTYKDRGFDVLGFPANDFAGQEPGTAQEIQKFCTLSYNVTFPMFDKTVVTGAEKSPLYTQLIAAQPVARVADPKFKDNLRGYGLTVNEEPELTWNFEKFLVNRKGEVVARFAPDTLPTDDAVIQAIERELTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C3</accession>
    <name>E8X2C3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0988</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579379.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0988"/>
    <dbReference type="EnsemblBacteria" id="ADW68055">
        <property type="protein sequence ID" value="ADW68055"/>
        <property type="gene ID" value="AciX9_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0988"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120900_1_0_0"/>
    <dbReference type="OMA" id="FDHYGQM"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234296" evidence="1">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="191" mass="19833" checksum="9F15D3EAFE0C877B" modified="2011-04-05" version="1">MRKILVLAALAATTFGAHAQMGNMKMPAAAAVAGDPAKADDSMLTDFEGEFMAAAKAMPADKYSFTPASLNIPGAKFDGVRTFGEEVTHVAQANYSIYAGLMGAKPDVDVKAIGNLKSKDEIVAAATASFAYAHKAIATLTAANSNMTLRAGHADTKSSLGAYGVAHGFDHYGQMVEYLRMNGIVPPASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C6</accession>
    <name>E8X2C6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0991</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0991"/>
    <dbReference type="EnsemblBacteria" id="ADW68058">
        <property type="protein sequence ID" value="ADW68058"/>
        <property type="gene ID" value="AciX9_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0991"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_0"/>
    <dbReference type="OMA" id="DRPIFAL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="39947" checksum="8876E7246F174AEB" modified="2011-04-05" version="1">MGKLRIGIVGAGPGGLTLARILYVNGIEAVVFEREASTSDRPQGGSLDMHAKSGQYAIACAGLTTDFRRIARYEDQESRIYDKDGRQVFLEEDLTGKDRPEVDRGQLRQMLLDSLPDGVVRWGSELVAAMPCVDGGFELELRGGVRERFDLIVGADGTWSRIRPLVSDARPVYSGVTFVEMGIDDVDVGFPELARLAGRGLTFAVGERKAIIAHRDSGGHLGIYASLRVPEGWTGSGDLRAYLLAQFEGWDEGLRRLIAESGERMVPRPIYALPVGHRWENQAGVTLLGDAAHVMSPFGGDGANLAMWDGADLALGLVSGSDWRGAVRDYEERMFGRAEACAAGAAEAIEEVFSEDGLEHIVAAMRGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D1</accession>
    <name>E8X2D1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="11" type="ordered locus">AciX9_0996</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579387.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0996"/>
    <dbReference type="EnsemblBacteria" id="ADW68063">
        <property type="protein sequence ID" value="ADW68063"/>
        <property type="gene ID" value="AciX9_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0996"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_0"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="46540" checksum="8744B00B54627488" modified="2011-04-05" version="1">MTISELKEHNIAELGKLARGLDIGGTSGLRKQDLIFKILQAQSEKEGHIFAEGVLEILPDGYGFLRSPDYNYLPGPDDIYVSPSQIRKFDLKTGDTISGNVRSPHEGEKYFALVKIEAINFESPEETRNKVLFDNLTPLYAQERVKMETVREHISGRVMDLLTPVGKGQRGLIVAPPRTGKTMLLQSIANSITANHPEVVLIVLLIDERPEEVTDMQRSVRGEVISSTFDEPAARHVQVAEMVIEKAKRLVEHKRDVVILLDSITRLARAYNTIVPPSGKVLSGGVDSNALQRPKRFFGAARNIEEGGSLTIIATALVDTGSRMDEVIFEEFKGTGNMEVILDRKLVDKRVFPAIDIQRSGTRKEELLIPKEDLQRTWILRKVLNPLSPTEAMELLTDKLAKTRNNQEFLHNMSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I4</accession>
    <name>E8X2I4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="15">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">AciX9_2164</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="15"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580524.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2164"/>
    <dbReference type="EnsemblBacteria" id="ADW69208">
        <property type="protein sequence ID" value="ADW69208"/>
        <property type="gene ID" value="AciX9_2164"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2164"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036876_1_1_0"/>
    <dbReference type="OMA" id="KMTGTYP"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04213">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034236">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0186">Copper</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="18">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="123"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="249"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ADW69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="37914" checksum="4D3C778B2D639CC6" modified="2011-04-05" version="1">MLVVVDGIITVISEYCPFMLQLSCFVPTNIFMPAASPARAIFGLSILTLCIVTAIFLVVGGLLLYALIKFREKPQQDDREPVQLFGSNQIELSWTVIPILIVVVLFLATARVIIATERSHPPEGALHVTVVGHQYWWEFRYPGTQVVTANELHIPTSDPSHPRPTYLNMISADTDHSFWVPRLAGKMDVIPNKINVMWFDPQQPGLYLGQCAQYCGTQHAKMLIRVYAQTPSEFQQWMNAQALPAALDPQMSAGRAVFERNACMNCHQVRGTVADGRFGPDLTHFGSRDTLASGAVTNTPEHLRQWIADPSHYKDGALMPAMHLKDADIDLVSKYLESLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I8</accession>
    <name>E8X2I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2168"/>
    <dbReference type="EnsemblBacteria" id="ADW69212">
        <property type="protein sequence ID" value="ADW69212"/>
        <property type="gene ID" value="AciX9_2168"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2168"/>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016729_0_0_0"/>
    <dbReference type="OMA" id="DVWIADN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="631" mass="62592" checksum="F3987A82DF35D6F9" modified="2011-04-05" version="1">MKPDQASCCTRTDSVMRCSSRKHAMILSCGWLGIAAATIGCGSSTPSSTTTVTAPGSAFTGHITAAGQPVIGASVQLYAAGTSGNGTGAVNLLPGQTISSNSAGQFSIPQDFACPTSTTQTYLVAQSGNPGLAGGTDNRALLLVAALGDCGSLSITTTPIVNEATTAAAAWAFSTFLGASAAIGSSATNATGLRNAFALAANLVSISTGTIPGPNLPSSAKFETAKLNTLANALASCTHSEGGAACGPLFAAAQQGTTKPATTLDAALSIVRNPANNVTAVFAASSGQTTFQPTLASAPHDWTLSITYGNCTSGCGGLNLPGNIAIDSTGAVWVANYFGRVASKFSATGVAAATNGFVGTGLYASYGIAVDASDNAWVTNLQSFTPTNSYSGSVSEFSPAGAELSGLGYTGGGVYYPLAVAAGTNGDIWVADYGSSSASLLASNGTTLSGASGYAASQLPFTSAVALDATQNAWFAVQNGVARVTPLGAVTSFSCCDDPEGIAVDPSGDIWVADYGASSLIELSPSGQTMATLDTASAGASPKGIAIDGAGNVWAANYYGNSLTALTGSNAAFRFPTRTIGLDASLNEPYAIAVDASGNLWVSNSNSNALVEFIGLASPVKTPLLGPPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K0</accession>
    <name>E8X2K0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2180</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580540.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2180"/>
    <dbReference type="EnsemblBacteria" id="ADW69224">
        <property type="protein sequence ID" value="ADW69224"/>
        <property type="gene ID" value="AciX9_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2180"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_1_0"/>
    <dbReference type="OMA" id="CEVIPLQ"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="46"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="220"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="378" mass="41098" checksum="4235FA2C9F1FB4A8" modified="2011-04-05" version="1">MSQQDSPTPYPHWMLREIHEQPDSLTATLDRYVGPDGFREEVCQPIRTWLVAANKEIVIAASGSSRHAGMIAEILIEDICGTPVDVEYASEYCYRPERATKNAALLVISQSGETADTLAALRKANEAGHPTLAITNVINSTMAREASASFCTLAGRERAIPATKSFTAQLLNLQLLSLLAAESQQAIDAAELKTRLAQLASLPDTIKVQLEGWETAARAAADHFKEAESFLYLGRGVHYPVAREGALKLKESAYLHAEGYPSGELKHGPNALVSERIPLVMIATVDRSDADSVQRYDKVVQLMRDMRTQGANILAIANVGDQEVAAVATQVISVAEAPEPLLAICEVIPLQMLSYFMAINRGIDVDHPRNLTKAVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V3</accession>
    <name>E8X2V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579410.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1024"/>
    <dbReference type="EnsemblBacteria" id="ADW68087">
        <property type="protein sequence ID" value="ADW68087"/>
        <property type="gene ID" value="AciX9_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1024"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_0"/>
    <dbReference type="OMA" id="YPQDAQV"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="36598" checksum="FF7778E0508C88AD" modified="2011-04-05" version="1">MAEPDYVIAGAGIIGLSLALELHRRGASVVVLEAGTPMAQASTAAAGMLAADDPHNPIALHALAKVSTSLYPGFLDHISDLSGVRIPFQTASTLQAVSPDADFLSDPKALVPQLEPGSHRFSLLDERSVDPRQLAEALLMAVRNTRKIEGRGIDLRENTPLTRIAAGPASVRVETPAGSLSAGYFVDCMGAWSPAPVAPRKGQMLAVTLPKSLPLKTVIRTEKIYIVPRTDGPNAGRAIIGATVENAGYDLKVHPVDILTLNAQATALLPELAEALFVESWAGLRPATRDDLPILGPSPRQPRYVLANGHFRNGILLAPATAHVVAQLLMGENVDVDLAPFDPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y1</accession>
    <name>E8X2Y1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1052"/>
    <dbReference type="EnsemblBacteria" id="ADW68115">
        <property type="protein sequence ID" value="ADW68115"/>
        <property type="gene ID" value="AciX9_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1052"/>
    <dbReference type="HOGENOM" id="CLU_3403797_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="30" mass="3253" checksum="91DA73CFE9AAFEE1" modified="2011-04-05" version="1">MRFPLNLLQYVASVVLVIAGIVLLCTPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X339</accession>
    <name>E8X339_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580579.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2220"/>
    <dbReference type="EnsemblBacteria" id="ADW69263">
        <property type="protein sequence ID" value="ADW69263"/>
        <property type="gene ID" value="AciX9_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2220"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079104_1_0_0"/>
    <dbReference type="OMA" id="ERWGINY"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="33062" checksum="BC9C44564C3987CA" modified="2011-04-05" version="1">MNIAIAGATGALGTRITKSLIANGATVKALVRPGTDPSRLLPITKQGVEIAELNLDSPQELTRALQGTDCLISALLGLREVMVETQTTLLDAALKARVPRFIPSDYAMDFTRLTPGTNRNLDLHRDFQQRLDRSGIQATSILNGMFMDLLTGEAPFYLWKIRRVLCWGSPEQKMDFTTMDDTAAFTARAALDPTSPRWLKIAGDQRSARELAAIASNITGKPFKTLRPGGLPVLAAIINVARKLNSAPSEPFPAWQGMQYMHNMYEGKALMTDLANNRYPGMNWTTVQNLLTDFLQTRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X363</accession>
    <name>E8X363_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2249</name>
        <name evidence="8" type="ordered locus">AciX9_3869</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">pACIX902</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69287">
        <property type="protein sequence ID" value="ADW69287"/>
        <property type="gene ID" value="AciX9_2249"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71151">
        <property type="protein sequence ID" value="ADW71151"/>
        <property type="gene ID" value="AciX9_3869"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2249"/>
    <dbReference type="KEGG" id="acm:AciX9_3869"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_0"/>
    <dbReference type="OMA" id="GYQGVHK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="136"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="35888" checksum="5A246E2E19599892" modified="2011-04-05" version="1">MAMRQQTFASQSSFEKYGRELFLDEMEVVVPWVELQALVEPHYPKACNGRRPVGLGIMLRTYFMQQWFNLSDPGVEEAFHESFTLRRFAGVDLGVAPAPDETTVLCFRHLLEKHDLGGAMLDAVNLHLAAKGIRIETGTIVDVTIIHAPSSTKNEKKERDPAMRQTRKGKQWYFGLKAHVGVDAKEGHRHSVATSAANVSDVPMLPDLLHGEERKVWGDGGYQGQTKAIRQAAPKAQDMTCKRTRFKNYVDEAAKKKNTTKSKVRAKVEHVFRILKRVFGFDKVRYRGIAKNHHRLCTNFALINLYLHRKHLAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A0</accession>
    <name>E8X3A0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3395</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3395"/>
    <dbReference type="EnsemblBacteria" id="ADW70401">
        <property type="protein sequence ID" value="ADW70401"/>
        <property type="gene ID" value="AciX9_3395"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3395"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OMA" id="VVHTDYV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="29643" checksum="FC95E44BFAC475D7" modified="2011-04-05" version="1">MSTYPPNQDSSASTTERLQTRRSEPAVNQVPRKILVLGATSGIAEATCRIWAQQGASLFLVGRNQQKLDAVAADLKTRGASYVDTAVADLDDTSSHPALLAHAINSLTGMDIAYLAHGVLGDQTEAEQNFEVAAQILHTNLMSAVSLLTWLANFCVQRHAGTLAVLSSVAGDRGRKSNYVYGASKAGLSAFLAGLRNRVDREGVHVITIKPGPTRTAMTASMPGSEKFADVNKVAATIVKAIDNGTDNLYVPFQWQPIMFIIRHIPERVFKKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C7</accession>
    <name>E8X3C7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3422</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581740.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3422"/>
    <dbReference type="EnsemblBacteria" id="ADW70428">
        <property type="protein sequence ID" value="ADW70428"/>
        <property type="gene ID" value="AciX9_3422"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3422"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066586_0_0_0"/>
    <dbReference type="OMA" id="VCGDAWA"/>
    <dbReference type="OrthoDB" id="980946at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="36361" checksum="5FBAE54450DEE802" modified="2011-04-05" version="1">MEPIAQSVVVAVDEETAIAEARRTTAALCQRIGLSAEIIARAELVAVELAGNILQHAGHGRLYLSSTPTADALQIIAIDSGPGIANVERAMADGFTTSTTPGFGLGAVGRLAAGVDIYTQLGKGTILSAIVGPQHPSLPGQTAVLSTSLEGETLCGDSWAVFPALSHTFQEHRQVYMVVDGLGHGLHASEAAAMAVSIAHSAFAAEPGLALDVLINRMHGPMHATRGAAILLVSVCENIATCCGVGNISCSLHAPDGTDRSLVSNNGTVGHVMRKIQEFRYPYTPGTLLIMHSDGIATKWRFGQYPRLEEKSPATIAGLIYRDAVRGRDDATVLVSRLGASSAQAVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K2</accession>
    <name>E8X3K2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1130</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579516.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1130"/>
    <dbReference type="EnsemblBacteria" id="ADW68193">
        <property type="protein sequence ID" value="ADW68193"/>
        <property type="gene ID" value="AciX9_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1130"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_7_0"/>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="161"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="429"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="830" mass="89743" checksum="4092B2F70707FA25" modified="2011-04-05" version="1">MPVKLKIGPNAPKIGFFSHIFRFLVVVVLFVVLIGIAVFAYYYHDYQRIVDERLAAGPLFASVAQIYAAPKEIRPGQHLSAENIAYDLRAAGYNVNQQLGTYDLRGSSIFIKPGPQSYHSPDGATITTSGGEVTSITAENGATLRAYQLEPLLITALSEDKNRTKRRLVTFDEIPPRLIQAVTAIEDRRFFEHGGVNYFRMAECAIQDFTSHAKECGGSTLTMQLSRGFFLTPEKKYSRKLREIMITFQLENRFSKQQIFEMYANQINLGQRGSFAINGFGEAAQAFFGKDLSRLDTAQYALLAGTIQSPNRLNPYRHPDRVMERRNVVLDSMVKTGALTQDEAEAAKAEGLHLAPANVDASEAPYFVDLVHEQLVQRLGDNLGAQSLRIYTSLDPDLQRAASDAVEAGMRNVDAMVSKRGGGTYPQVALVALDPHTGQILAMVGGRNYGTSQLDHATSMRPTGSIFKPFVYATAFNTSLSGTSLDGNGPFTAVTRINDDPQDFGLNGQSYVPGNFEKGEYPGMVTAADALAHSLNIATIALAHKVGYENVAALARSSGIASAKATPSVAIGTYSATPIDMAGAYTVFANNGVHLTPWTLASVRNNSGDIVADFAPVASQVLDARVAYLTQSLMQGVMARGTAATVHKYGFNSPAAGKTGTSHDAWFAGYTSNLICIIWVGNDDYTDVKLQGALAAAPIWAEFMNRAIRLPQYSDVHEFTKPEGVTNIGIDRASGLPADSSCPAAYTVAFLDSTIPAGSCSRMSDSHQSIVDLLNGTTTPVQPGQPEPQPTSPANPNDPYAPPPPKKKNFFKRLFGAGNQQQQQEPPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N0</accession>
    <name>E8X3N0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1158</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579544.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1158"/>
    <dbReference type="EnsemblBacteria" id="ADW68221">
        <property type="protein sequence ID" value="ADW68221"/>
        <property type="gene ID" value="AciX9_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1158"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_0"/>
    <dbReference type="OMA" id="FRTALMQ"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="23759" checksum="342CF616A1FA324A" modified="2011-04-05" version="1">MGLREKKAQRSRDRIVAEAMTLFSRNGFEPTTMESIAEAADVSPSTLYRYYPTKDSIVLASFMGNTARFSEVFALSLKDLPVERALAEAIFAVLAIEDKEPKHALLVRSILGQSPAARAHLWDYLGEQQRELARLLAQATNTAPDDPANILTSRIALEVLLAAADIWRANKGKQSSRATAENLMTLLTTGAVLFPEAASTPTPPTPKRPASTKPKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P4</accession>
    <name>E8X3P4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2284</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2284"/>
    <dbReference type="EnsemblBacteria" id="ADW69322">
        <property type="protein sequence ID" value="ADW69322"/>
        <property type="gene ID" value="AciX9_2284"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2284"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_8_2_0"/>
    <dbReference type="OMA" id="VINPWEA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="16469" checksum="46A3C2EDDB32F4F6" modified="2011-04-05" version="1">MTSGFLLDTNIPSEQMHVLPDLRIGIWMYAQPESSLYLSVMTIGELRKGTTLLPEGKRRRQLEQWLDHELVPRFHSRILPITQTIADHWGILSARRQRQGAPLSMADGLIAATALHHNLTVVTRNIKDFTDLGVPLLNPWESNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R6</accession>
    <name>E8X3R6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2307</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69344">
        <property type="protein sequence ID" value="ADW69344"/>
        <property type="gene ID" value="AciX9_2307"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2307"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048410_0_0_0"/>
    <dbReference type="OMA" id="GACCRQL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="27864" checksum="CD059D874A827AC3" modified="2011-04-05" version="1">MKSSVDLPPTVQVNFTLGIGHGRLDASLEVPSGHVTLTQILPVLQTLTSNIVDAATVLVSTEGYQVSCRAGCGACCRQLVPLSIFEAEFLTEWIHSLPAMQQQALNARFNTTVDALKATNLLPRLLTPHLWQEEDLEARTLAADYLEQEIPCPFLHDESCSIHPIRPLICREYLVTSDPVFCARPTRETVVPIPIPLKSSSVLFGLGSLVEEGTTGWIPLPLLFVWMQTGGTPGQAIEGLGHELLHEFVKRYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T4</accession>
    <name>E8X3T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2325</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580678.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2325"/>
    <dbReference type="EnsemblBacteria" id="ADW69362">
        <property type="protein sequence ID" value="ADW69362"/>
        <property type="gene ID" value="AciX9_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2325"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_5_0"/>
    <dbReference type="OMA" id="GHWAVNA"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230205" evidence="5">
        <location>
            <begin position="18"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="242"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="614" mass="67047" checksum="9799A252B3C02FA8" modified="2011-04-05" version="1">MRKPLLLLSVCATHAFAQSPVSTNPQQTALPSTEAAVNVTSAIQPMLLSGSDRSFVVLDPEATALLNDNVTDYLRMDASVNLQSRAGNGVQADLSIRGTTFEQSLVLLNGFRINDPETGHLNLDIPIPLEAISRVDVLHGSGSTFFGSDAIGGAINLITARPSRTSVTAKAGFGNYGSEEQHLQATYAASRFAGELAGSRDTSDGFMVDRGYHSNALSSETWFDLRPHPSSQSAPKDAWTTDLLFAASDRPYGANQFYGAYDSWERAKGWFASIQQQLGARTIGQFAYRRHSDLFVLLNDNPQYYRNNHLDGAWEGALRRTDDVRHDLSISYGLEADGDSIHSSNLGLHARNEEAGYVSVAYHPQGRFTAIAGAREEGLSGGRSVFSPSLAAGFSLTKTLRLRASAGHGFRLPTYTDLYYSDPASIGNPALKPETSWSYEGGLDWTPGGRYTFSATGFRLQQKNSIDYSKYTLAAPWQATNINDLNLTGAESSLHIRLPATQTLQLRYTAVQAAPPPPGLISEYAYNYAAQDANLLYTASFWKQWIAQTELGVIQRTGHTAYPLWDLSIARSSGRIKPYLRLMNLSGTGYEEIVGVRMQGRTVMGGLAYSWTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y5</accession>
    <name>E8X3Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3488</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3488"/>
    <dbReference type="EnsemblBacteria" id="ADW70493">
        <property type="protein sequence ID" value="ADW70493"/>
        <property type="gene ID" value="AciX9_3488"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3488"/>
    <dbReference type="HOGENOM" id="CLU_3136214_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="5352" checksum="97AB9DC1AE2C0CD9" modified="2011-04-05" version="1">MLIRPTKTPKKKSFETHDIAAIATRAEQGKAPTRHTVKLPKTATPGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X433</accession>
    <name>E8X433_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0002</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67093">
        <property type="protein sequence ID" value="ADW67093"/>
        <property type="gene ID" value="AciX9_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0002"/>
    <dbReference type="eggNOG" id="ENOG5033UBI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993682_0_0_0"/>
    <dbReference type="OMA" id="RERYICK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234346" evidence="1">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="29582" checksum="0C29F4A133EFD1AB" modified="2011-04-05" version="1">MRRLLFVGTVAALMPLCGGVAGAQALPGVAELRARALESYQKSSAARERYICKELIRNDELNGNGEVKKSYLDEREIFYVNGFQISQEVSKNGRALNEGEIRKRDENVRKQIEAASDHKRPKTQGLVISAGDVLRLAKLDHERRVMVAGRPTIVFDVVPDDDAKASTVEEKLVAAMAGTVSIDEATGNLQDVNTTGAKDVKVGGGLVANVHKGFAMHILVAPEPDGVWLLKLAEGTGEARIGLVTKSAMRFHQETEGCKLYDVDATQVDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A0</accession>
    <name>E8X4A0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane prediction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0069</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578489.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0069"/>
    <dbReference type="EnsemblBacteria" id="ADW67160">
        <property type="protein sequence ID" value="ADW67160"/>
        <property type="gene ID" value="AciX9_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0069"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094965_0_0_0"/>
    <dbReference type="OMA" id="FAAHLMV"/>
    <dbReference type="OrthoDB" id="1738709at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="20286" checksum="AFA6771BF4E099EC" modified="2011-04-05" version="1">MPPREGVYGFLAEFNTPSDLVHATEIAYREGYRRMECYTPYPVEEAAEALRFHKNRVPLFCLLGGVMGLTTAFLMQTWINTLAYPLNIAGRPLESWPAFIIPAYEWTILFAGLSAAFGMIASCGLPQTYHPVFNAPNFRNGATTDKFFLCIEAFDPKFSLTDTRLFLEQFPAVSVVEVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G1</accession>
    <name>E8X4G1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579611.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1225"/>
    <dbReference type="EnsemblBacteria" id="ADW68288">
        <property type="protein sequence ID" value="ADW68288"/>
        <property type="gene ID" value="AciX9_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1225"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="RTNEYIY"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234159" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1126" mass="120378" checksum="234BF7A7C5FD3A05" modified="2011-04-05" version="1">MKLHPIVSASLFAISASAAYAQVAADLQGRVVDASGAAVPNAAITLRSAATAIPQQTTSSSAGDYTFTHLVPGTYTLDVTAPGFQHLSRRGVTVIVGQTVTADLPLVVGSETQSVTVTADAPLLQQATSNIETNIPGTTVAAMPLNTRNFIQLATLAPGVELPPGTLLPRINGGRPRTNEYIYDGISALQPEPGQVAYFPIVDDIQAFTIEADNVPAEFGRFNGGVVNVATRSGSNQIHGSLFEYFRNEILNARNYFSPAATVPRKPEYRRNLYGATLGAPILHNRLFVFGDYQGVKQLIGKTVTSTVPTLAERGLVTPSVYSFAGVSKIYNPFAATTTGGRTIRTEFANDSINCALIKCDPAALALLARYPLPLTTALANNYSRTANDADHQNQFDFRVDGAFRSRDRAFGRYSYYNEVEQPITFLPDGSGPAVTGIIGTGAVSGLTSILGQQAVFGETHTFTDHLLNDAHVGYTRRGNISSGPSLANTASTALGIPGIPTNAAFNNALPLFTFSAGAFQQFGPAASTFANFQTAVWQFTDSVNFTRGRHALKFGVDYRWYQLNTIAPPNPTGSFAFTTTGTNTQSTAAAATTGGNALASFLLGQVDTFSIDLQTSKLRPRDHIQEYFVQDDWRATDRLTFNIGARWTLHFPSTEKNNQGAIFNLATQQLDYVGVNGNSKSARQLHYTNVAPRLGLTYLVDPKTVIRAGFGIVFIDQSGITTPFTVPQFPFIQNVQQATQDSISSPFTLSNGPTVAPIALTPSAGLGQSVYTANRTAGSGYVQQWNLAFQRQVTNNLSVDVAYVGSHIVHVGIPDSNLNQLTQAQLTAGGTALQTKVTNPYAGQLPGTLGAATISNAQLLKPYPRFQNVATYRNNSGTTNYNAIEAKVEQRLTKGMYLLAAYTHSKLIDDASSVFSSTVLSSPNTSSLIAADAFTPRLERDSSNGDMPNVTSLSAIYDLPAGRNHRFANNAIGNTLLGGWQLNAIMSLQSGMPVTVTQATNNNAFAGFSLQRPNLIANPKFAPELRSPGKFFNTAAFQAAPTFVIGNASRNPVRGPAFRDLDAALVKHTHIGDRTDVEFRAEIFDITNTPAFAQPNGSVGNAAFGSITATTTDPRVVQFALRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J6</accession>
    <name>E8X4J6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2369</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2369"/>
    <dbReference type="EnsemblBacteria" id="ADW69406">
        <property type="protein sequence ID" value="ADW69406"/>
        <property type="gene ID" value="AciX9_2369"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2369"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530768_0_0_0"/>
    <dbReference type="OMA" id="CGNQYRP"/>
    <dbReference type="OrthoDB" id="832170at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="460" mass="46352" checksum="28453824EDA9496F" modified="2011-04-05" version="1">MHSVHQHAAVRSSSRRIARPFARFALALAAVSLAGCGNQYRPVVSSVNPVGPASQPGKYAVAVSSNGTTSPGLVTIVDFSGDTTLITANLGANPQYLIVDPTGSEGYVLNGDGTFNSFAVSTSLLTSNVLQSTLPVGAAPVAILPQGTNLYIAEAGRNAIGQLTGSPSALKQELVTGPGTVYTVGISGAPRVYAITQGATGTAGAVKAIETTTNTISNTINVGTTPVYGVMTSDARRAFILNKGSNTVTVINSQTNAPDTFTGTAGTATNTIAVGTAPLWADFDNTRSELLVANAGGGTATTPGSVTVINIPLCSANTVTTNPNCDVNNPVDAVGFGQVLANIPVGVNPVQIAVLADGSQAFVANAGNAAAGIAGSVSIINLQTDTVVATIPAANTTVQGDAFVHGHPGTIAVTAGNPTGKVYITSPDSTDLTVIRTDTDQVQTHITLQGNGVYVRTNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X565</accession>
    <name>E8X565_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1267</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579652.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1267"/>
    <dbReference type="EnsemblBacteria" id="ADW68329">
        <property type="protein sequence ID" value="ADW68329"/>
        <property type="gene ID" value="AciX9_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1267"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_37_1_0"/>
    <dbReference type="OMA" id="ERINCHR"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="42763" checksum="D4F80D95D65361D4" modified="2011-04-05" version="1">MKVALATIGKFHTFALARQLLRFDALATVITGYPWFKLQQEGVPRQFVDSFPYVHGPYMATGGKVPASITRAISALDRVSFDQYARLRMKPYDIFHWLSGFNLKSARAARNKGALLIVDRGSTHILHPDEILRPEYDRLGLPFTPTPPIAIEYELAEYGLADAITLPSSVCLDTFVQHGIPREKLLLTPYGVDVDRFQPLERPPQSELRVLFVGSLSVRKGVHYLLEAFDRVTHPNKTLHLVGTESLDYAPVLAPYRNRPDIRFHGHLGQHDLNTIMSGSTVLVLPSVEEGLALVQAQAMASGCPVLATNVTGSPDLFTDGIEGFIVPPASPDALADRLQQLADNPGLADALGQAARTRVEHLGGWNEYGDRMFAHYNALLEKHGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X576</accession>
    <name>E8X576_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1278</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1278"/>
    <dbReference type="EnsemblBacteria" id="ADW68340">
        <property type="protein sequence ID" value="ADW68340"/>
        <property type="gene ID" value="AciX9_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1278"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146069_0_1_0"/>
    <dbReference type="OMA" id="YVGTYYH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="11015" checksum="A78F6AC4EE1ABCF6" modified="2011-04-05" version="1">MLSQILQQNPTDSFARYGLAMELVSQKRIPEALAEFDTCIQHNPDYVPAYQMSAQTMAANAQPEAAIERLHQGIATANRTGNQHALAEMEALREDLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X583</accession>
    <name>E8X583_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579670.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1285"/>
    <dbReference type="EnsemblBacteria" id="ADW68347">
        <property type="protein sequence ID" value="ADW68347"/>
        <property type="gene ID" value="AciX9_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1285"/>
    <dbReference type="eggNOG" id="ENOG50338D5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122421_0_0_0"/>
    <dbReference type="OMA" id="MGPRENA"/>
    <dbReference type="OrthoDB" id="1540270at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="185" mass="20486" checksum="5920D9D3D5634201" modified="2011-04-05" version="1">MPDPSFSQPERRSLILPIVLGLALLGVIFAVVAHLRPTASVAVTHVHTDLLPTSTVFKSDSIVMGPRENARQLFVATTVRIDNKIHIPIYLDDFTCTFTDPSGAIMKVTAFANPDLTNIQTSFPKLQPLMQTPLKRETRIDPGQTLQGTILLSFPFTEAQWNARKSATIEIDLYHQAPLTLDIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E5</accession>
    <name>E8X5E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2457</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580808.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2457"/>
    <dbReference type="EnsemblBacteria" id="ADW69492">
        <property type="protein sequence ID" value="ADW69492"/>
        <property type="gene ID" value="AciX9_2457"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2457"/>
    <dbReference type="HOGENOM" id="CLU_2193256_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="12114" checksum="CAEF827C95D6AC68" modified="2011-04-05" version="1">MISRRAQRAQWASRLRGQASVNTALNLRVGRVVFDGISRGSARRIVDGLEAYLGDALHESLSSGQQASWPRTQKLAELRGAIPRGLRERERGEHLARTIAELLEEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H3</accession>
    <name>E8X5H3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ordered locus">AciX9_2487</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580836.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2487"/>
    <dbReference type="EnsemblBacteria" id="ADW69520">
        <property type="protein sequence ID" value="ADW69520"/>
        <property type="gene ID" value="AciX9_2487"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2487"/>
    <dbReference type="eggNOG" id="COG0689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_0"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="26076" checksum="7421E65E1850F0BF" modified="2011-04-05" version="1">MSSPVFRPDNRTANQLRPTRITPGYVSTPEGSVLIEVGNTRVLCNATIETGVPGWMRNSGKGWVTAEYGMLPRATLTRSPREAEKGKIGGRTHEIQRLIGRSLRGIVDMRALGERTIILDCDVLQADGGTRTAAITGASVALAIALGKLVQAGTLKASPLKQMIAATSVGIVDGNTLLDLAYEEDSRATVDMNVVMLASGGLVETQATAEKDSYSRQQLTEMLDLAEAGIRDLLILQQTALTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S0</accession>
    <name>E8X5S0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4008</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572716.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70804">
        <property type="protein sequence ID" value="ADW70804"/>
        <property type="gene ID" value="AciX9_4008"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4008"/>
    <dbReference type="HOGENOM" id="CLU_346064_0_0_0"/>
    <dbReference type="OMA" id="GSFTQMF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="816" mass="81443" checksum="35E357FB7A822479" modified="2011-04-05" version="1">MADPNFKNDSEMNRAQASSGGATDIFGTISSDSAPGEKDDELARLLGLASAPPVAQASAPGWEPVATPVKEAEAVRPAAPMVHEVTFKEDNTAAQDGSEALKNLLRNSPPAAPVAPVAPAPVAPPPPPAAPLVPNSGFTQLLRALNYDQPPATAPVAPPPSPVAAPPPAAPAVESITQLLRTIDEPVAEAKPVEAAPLKKAQVTSFRGAPATVGAPAPEGVAAPPAAPVAPVSQPGSFTQLFNTLDFAPPAPAAPVAPPAPVLPPVAVETVAPYVAPETAPPVIAAPMAAPAAASPGSFTQMFQALDTSPAAPPVVETQAAAPAPAPVAAEAGPGSFTRIFNTLDMPLPSSEQLAPKASEPGSFSRPAQVPEAPPGSPSPGSFTQMFQALDAAPAASTPIPAPPAEPVRAPVVAAPSEPAAAAPKASEPGSFTQMFNASTMSPQSAPQHEAPRYTPEPVAAAPKSEPGSFTQMFSALSEPETKPALPEARGYVAAPPPPAAPPAPPAAASDGTFTQLFRTLDSEPAESKPAVSQPVRQEAAGGDPFGSPDPYSRPSVAPPASSDAGMGASQMFSTYAEPQARRPETVAPPARDMGYSQPKPPPQAPPAGSGGLTQLLRTLDQPAQSSTPSSAWEAQTPNAQGFPPAGLPAAGFPPAGQAPMYTPPPVAPSGAGPSEFTRIVTASALREAGLRGPSGGGAPAEAPAAAAGGSPLGVTFTPPSMSMPHMPAMPSAGSGAAPHFAPPAMPGMPGASGGGVHFTGPAMPSAPAVPQLKAPELKVEAPAAGKMQQMLPLLLILVIFLLVAILVAVVLLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X632</accession>
    <name>E8X632_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliP</name>
        <name evidence="13" type="ordered locus">AciX9_4136</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
            <plasmid evidence="14">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572828.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70916">
        <property type="protein sequence ID" value="ADW70916"/>
        <property type="gene ID" value="AciX9_4136"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4136"/>
    <dbReference type="HOGENOM" id="CLU_042028_0_1_0"/>
    <dbReference type="OMA" id="MPPNQIL"/>
    <dbReference type="OrthoDB" id="1049349at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25661" checksum="6F4F8BD7337D73B6" modified="2011-04-05" version="1">MIAALGSVFLHAPGATANANGLQITGLGGASAPWTIVVLLTFLSLIPSLLLCITPFARLLIVFHFLRQALGLQTTPSNQTLIGLSMIMTFFLMQPVGAVIYDTAVTPLQAGTITPLQALERAGTPMRQFMAHYVRDKDVALFLELAKEPRPHNVQDLSFRVMLPAYILSELKAGFQIGTVLFLPFLVVDMVVASITTSVGMMQLPPVVISTPLKLLLFLMVDGWHLLISSLMRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X636</accession>
    <name>E8X636_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4140</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572832.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70920">
        <property type="protein sequence ID" value="ADW70920"/>
        <property type="gene ID" value="AciX9_4140"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4140"/>
    <dbReference type="HOGENOM" id="CLU_013687_2_1_0"/>
    <dbReference type="OMA" id="FRATEQA"/>
    <dbReference type="OrthoDB" id="704242at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="6">
        <location>
            <begin position="179"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="41304" checksum="DAA0C0A548EB0A34" modified="2011-04-05" version="1">MSFFGVPLSGLIASQSQLQAVSNNLANLDTVGFKDQNVNFSDVFAQSSLNNGSNDPVQTGLGVNASQTTSDFTDGAVSATGIASNMALTGNGFFVTKTATGATAYTRAGDFTKNSSGQLVTPSGDLVMGYPAANGVVNTSGELQPIQIGTGTVIPASATTKFTISANLNSSAAVGSTFASPTPVYDSLGDAHTLTVNYTKTGTNTWSYSVDLPTADTGAATTTVASGTLNFDTSGNLTSPTGSVAINVPTLTDGAASMNFAWNLTDSSGNPTLTQTSLVSANSTSTQNGNASGTLTGYSIAADGTVEGTFSNISNPVALGQVAVASFANTQGLLRTGNNDYQATVGSGAASVGTAETGGRGVITGGSVESSNVDVAAEFAKMIVAQQAYQANAKTVTTFDQISQATLQMITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C7</accession>
    <name>E8X6C7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4235</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572923.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71011">
        <property type="protein sequence ID" value="ADW71011"/>
        <property type="gene ID" value="AciX9_4235"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4235"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_0"/>
    <dbReference type="OMA" id="TEMGCNH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="239"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="381"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="642" mass="71750" checksum="3BC4922B4A41B80E" modified="2011-04-05" version="1">MTAAQETYQASPKEVRTLFEERHKQLCARTDRSIAFIMCMQWIIAILAAYIISPQTWQGSSPSIHPHLIAAIYIGGLITLFPVYMVIQFRGDRFTRHIVAACQLLMSALLIHITGGRIETHFHIFGSLAFLAFYLDWQVLLTATVTTLLHHSLFGYFAPVSIFGTVNASAWRFSEHVLWVVFFDIFLIISCTKGIQNLKDVAQREADHIFRSFHDSLTGLANRALLQKAFEENNATSPEDRVLMVMDLDRFKQVNDTLGHRVGDHVLVEVSRRMKDILGEETLLVRTGGDEFAALIDNPSSLQTVELLASRIVSILTLPILSGEHIIQIGVSIGICPRDQVNASLSDLLHCADLALYKAKNTGRNRYLVFEESMKARSLQEMSIEYRLRSAIDQGSFKLHYQPIVSADAVLLGFEALLRWEDGANGEIPLSDFLPVAEDTGLIVPLGEWVIREACAQAAAWHRSGNKLVKMSVNVSARQLASESFVGNVLRCLVESGLPPAHLCLEMTENVLAQNYPETSGPLRLLSNYGVELSIDDFTIDPSSWTYPADLPIHTLKIDRRVTRAMMQSDDYAERIGAAIGMAHMRRLTVVAKGVETREQLELLRGMGCDEIQGFHISQAVSSERAKELLETYSKVDYLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J2</accession>
    <name>E8X6J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582163.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71142">
        <property type="protein sequence ID" value="ADW71142"/>
        <property type="gene ID" value="AciX9_3859"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3859"/>
    <dbReference type="HOGENOM" id="CLU_005679_0_1_0"/>
    <dbReference type="OMA" id="PFELECY"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="38953" checksum="3087597B61EFF107" modified="2011-04-05" version="1">MKKPRSLRENNFDIVRILLALIVVFVHSYELSQQRSLRVIDVVLNSRFAVEGFFTISGFLIFASYERSRSLREYAANRAWRILPGYWLSTVVCLVIAFVFGQFHVGRFLAANLTFLNTFSPDIPGVFTGNASRAMNGALWTIKVEVMFYVAVPLIVWLCRKTHRDAMLLILFLSSIAYRMVLANHTSLAQQLPGQLSFFVMGSLVYYHLPLFKRHGWWLVAASVAVYGLHRATDWFFLRPAPVAIFILAACLLLPQVKGPTRWGDFSYGTYILHFPIIQLLIHFGLFQLHPWTSVGLVLLILIPCAALSWFLIERPCLEHARSRRLREAALGHTTAFPPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N8</accession>
    <name>E8X6N8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3912</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582206.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71188">
        <property type="protein sequence ID" value="ADW71188"/>
        <property type="gene ID" value="AciX9_3912"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3912"/>
    <dbReference type="HOGENOM" id="CLU_012817_12_1_0"/>
    <dbReference type="OMA" id="NNAVHEY"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234454" evidence="2">
        <location>
            <begin position="25"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="47338" checksum="3FE52609A2746718" modified="2011-04-05" version="1">MKKHSFILCTGLALAPMASRPLPAQQAPAALPVITLDEALARASNSEPAYAAAQAASKTAALDRSIARSALLPSITYHNAYQFTQANGSTNQAGPSGSQSSPKFIANNAVHEYSSQGVVNETLGLGQLNAVARASAAAAVANAELEISRRGLTATVVTLFYSATTARNKVQVEQRAADEATSFVNLTTNREAARESAHADVLKAQLTQQQRQRDLADASLAAEKARLDLAVLLFPDPRTPYDLAIPPAKPLPTQPEIEVAAKTGNPELQSALASLRAANLDIKAAQSAYLPDLALNYTYGIDAEQFAVNGPGGVRNLGYSASATLDIPIWDWFSTQHKIKQTQILRDSAKVALTSTQRTLIAQLEEFYNEASLSERQLTSLQLTVDTARESLRLTRLRYTAGESTVLEVVDAQGTLTSAELALADGNVRYQQALANLQLLTGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P8</accession>
    <name>E8X6P8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Formate dehydrogenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">AciX9_3922</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="17 18">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
            <plasmid evidence="18">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71198">
        <property type="protein sequence ID" value="ADW71198"/>
        <property type="gene ID" value="AciX9_3922"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3922"/>
    <dbReference type="HOGENOM" id="CLU_000422_2_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-0614">Plasmid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="16">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="15">
        <location>
            <begin position="276"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW71198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111162" checksum="EE1CC7046BE06542" modified="2011-04-05" version="1">MNETLIEVAMPHVVVNSPEQVKVVVDGREVEARVGELVLTAVLRDKEIPHVCYHSELMGPIQSCDTCMVEVNGELVRACGHKVAAGMTIVTESKRATSARAEAFDVILGNHMLYCTVCDNNNENCTVHNTAVAMKVEHQEHPFKPKPYDVDMSNPFYRYDPSQCILCGRCVQACQTVQVNETLTIGWELDQPRVLWDGGMQIGGSSCVSCGHCITVCPCNALMEKSMLGEAGYLTSLPAKALDKMIDVIKAIEPELGYGAVMEVSQTEAKMREERIKQTKTVCTYCGVGCSYDVWTKDRKILKIEPAHGDANAISTCVKGKFGWDYVNHKDRLQKPLIREGNGFREASWEEALTLVAKKLGEAKEQHGPDSIGVIVSSKATNEDGYLMQKLARAVIGTNNVDNCSRYCQSPATMGLFRTVGYGGDSGSIEDIAASKLVLVIGSNTTESHPVLATRVKRAHKLHGQRLVVADPREHEIAERADIHFRPKPGTDLVWLCAMSKYMFDQGYEKKAFLAQWVNGIDAFRASLEPFTMEFAAATCELPMATLIEVAEEIAKADTMCVLWAMGITQHVMGSDSSTAISNLLLVTGNYMRPGCGAYPLRGHNNVQGAGDIGAMPNNYPGYQPVTDAAVREKFEAAWGTKLPPEKGMDNHQMVDAIYSGKMKAMYLAGEDMNSADSNANHVAGGFELLDFFVVQDIFFTETCRYADVVLPASPALEKDGTFTSTERRIQRLYQALPELGESRADWKITQDIANRMGAGWSYTHPSEMMAEMAALTPLYAGVSYERLEGYKTLQWPVAPDGTDQPILYLERFNFPDGKAKLHPLTYRTPMESPDAEFDLFLNNGRLLEHFHEGNMTHRVAGIQEETPERFLEVSPELAEERDIESGRWVRVTSRYGSLKIKVLVTARVQGKQVYLPLLSQEGPVNVLTGSHTDDATDTPAFKETAVKMLVLPERGSNPLKALNFRYSGKPTPQTGVEVERKWKRADYRMPGSAKLVQIQGMTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W2</accession>
    <name>E8X6W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASPIC/UnbV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3988</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582280.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71262">
        <property type="protein sequence ID" value="ADW71262"/>
        <property type="gene ID" value="AciX9_3988"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3988"/>
    <dbReference type="HOGENOM" id="CLU_017657_0_0_0"/>
    <dbReference type="OMA" id="QINFELA"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="498"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="579" mass="62225" checksum="939DC4A174D07BF4" modified="2011-04-05" version="1">MVDLVQRVSTSCLWGVVCIVLSGSVLAQSPPRSAMPDKVPSITFENTLKQSKIDFILKSSISPQRYSIETMTGGVAAFDYDNDGLLDLFFTNGAAIPSLEKTDASFSNRLFHNNGDGTFTDVTVKAGVAGLGYSMGVAAGDFDHDGYEDLYVTGVNHNQLLHNNGNGTFTDVTAKAGVLGNVAGVGKSWAVTAGWFDYNNDGLLDLLVVNYLNYDIKTAASCSEHKIITFCSPDDFKGLPNILYKNNGDGTFTDVSIPSHIADYTNKGMGVAFADYDGDGRMDIFVSNDTFPNLLLHNNGDGTFTDEALNAGVAYNEMGRTVAGMGAEFRDLDNDGRPDIFHTAMFGDSFPLYKNLGEKQFDDATSSSGLTAPTSRMTAWGVGAYDFDNDGYKDLFTANSAILDNSLEVEHRPFLLPNSLYRNLGNLRFADVSASAGGGFSVAAAHRGAAFGDFNNDGRVDIAVTVLNGSPEILMNHTVTQNHWLMLKLVGVKDNRDGLGTKVTITSSHGSQYNQATTTVGYNSSSDKRVHFGLGDATVVDRIELSWPTGIKQVLTHVKADQILTVTESSVTGSRGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X707</accession>
    <name>E8X707_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71116">
        <property type="protein sequence ID" value="ADW71116"/>
        <property type="gene ID" value="AciX9_3830"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3830"/>
    <dbReference type="HOGENOM" id="CLU_023620_4_2_0"/>
    <dbReference type="OMA" id="TVNDFHQ"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="55246" checksum="CD005278D839150F" modified="2011-04-05" version="1">MVRERRGCWVIVHSIRLQILGLLSVSFMRKSLLLMLVCHAALSSAQRTNSSPISTKYLYGKNSQIKVFQHVRVIDGTGGAVLQDQTLIVDGTKIKSMGHDAAVPAGAEVFDLSGYTVLPGLVGMHDHLYYLQRPNVDANGSEGPTLLPQMTFSAPRMYLANGVTTIRTAGSVEPYADINTRHLIEVGTLIGPHVEPTAPYLQGPSDLFMQMHSLKGPEDAKNFVNFWADSGSTNFKAYMHITRAELGAAIEAAHARHLKVTGHLCSVTYPEAAELGIDNLEHGFFVNTQLDPGKEPDQCSRETGNATLAKMTPDSPEAAALIKLLVAHHVAITSTLPVFEANLAGKPTLRPKALATLSPQALEAYLYGRNRRNTMPESAATQRGAANYKNDVGLEHKFVEAGGFLMAGLDPTGNGATLPGFGDQHEVELLVTDVGFTAAEAVKIATLNGAIYLGQQDRIGSVVAGKDADLMIVKGDPSTQITDIENVEIVLKDGMAYDSNKLLDSVKGRYGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X717</accession>
    <name>E8X717_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3840</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71126">
        <property type="protein sequence ID" value="ADW71126"/>
        <property type="gene ID" value="AciX9_3840"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3840"/>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_0"/>
    <dbReference type="OMA" id="SGAIDVC"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="7">
        <location>
            <begin position="199"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="447" mass="49766" checksum="67DEA2031E28BDB0" modified="2011-04-05" version="1">MHSTTITQVRVIDLRFPTSRDHIGSDAVNVDPDYSAAYCILETDSGLEGHGLTFTLGRGTDLVVSAIQHISTGIRGRTLEELTRDLNALYLNLTGDTQFRWLGPEKGVIHLAVSAVLNAVWDLYAKSEGKPVWALLADMTPAEIVRCIDFRYISDALSVEDAIELLTRGKLGQSERLAQLEREGYPAYTTSVGWFGFSDDKIRTLCQQALSEGWTHFKLKVGGAEQDDLRRGHIVREQIGWTNKLMVDANQRWGVEEAIRRTRLLAELNPWWMEEPTSPDDILGHARIRQESGVRIATGEHCHNAVMFKQLLQAEAIDVCQIDSCRVASVNENLAILLMAAKFGVPVCPHAGGVGLCEYVQHLSVFDFLSVSCSLENRVIEYVDHLHEHFVAPVAIRRGHYLLPKAPGYSAQILPASLAEFSFPYGQTWQASSEQNGKVDEVHIIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X752</accession>
    <name>E8X752_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4333</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573005.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71286">
        <property type="protein sequence ID" value="ADW71286"/>
        <property type="gene ID" value="AciX9_4333"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4333"/>
    <dbReference type="HOGENOM" id="CLU_018816_15_1_0"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="339"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="58931" checksum="091637B7A917393D" modified="2011-04-05" version="1">MADQQPPELPQLPQIPTDHLLPSEAGESHPMMDAALSTGHSAGHIAEPHADLALRMLYDEQTRLRTELNDLRRKSEEKKDDKKKGEKKDDQVGDDKEEEEGGDDKKDGEKKDGDDKKEEKPPLKERVHEVEKKTKGWTRQHPIATVAIIAGVIILIIATILLVHYLDSYESTDDAFIDGHTDPISFRISGIVSKVYVENTFRVKKGQLLVELDDRDNQVAREQAAANYAQSQAAVRAQSPNVGITATDQNTQVISRDYNVINNEAQVAQAEERYRSALADLRQAEAQEGNAIREEERYGMLVVKEEVTREQYDQRATERRTQAEVVASRRNSAEAAHKSVTQAEAQLEIAKQQARQARQDTPRQIQMQREMLAQRKASELAAKAQSDQSQLNLEYTRIYAPEDGIIGDKQVQVATQVAPGQELFALTQTNDIWITANFKETEIRRMHPGQGVTIYVDALSQKFQGYVEALPGGTGAVYSLLPPENATGNYVKVVQRLPVRIRINAGQDGAQRLAPGMSVEPKVWVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X798</accession>
    <name>E8X798_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4380</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573051.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71332">
        <property type="protein sequence ID" value="ADW71332"/>
        <property type="gene ID" value="AciX9_4380"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4380"/>
    <dbReference type="HOGENOM" id="CLU_024675_0_1_0"/>
    <dbReference type="OMA" id="PIVARIQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="477"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="543" mass="59995" checksum="406EE79D0E2A2FDB" modified="2011-04-05" version="1">MVIDASTVEEILDKDELVPCFQPLRELRTGRLTSFEVLARWAHPTRGLILPSNLIEVAEREGLLTRLTKQLLHKAFDTTKTLSPSITLAINVSPQQLRDVTLANQIAEIARRSEFSLDRLTIEITEDALIDNQRLAKTITQELKGLGCQLVLDDFGTGYSSLRHLHTLRFDGLKIDRCFIVDALESRESRKIVAAMIGLGQSLNMTTVAEGIESEEQASLLLYLGCDVGQGWLYGKPAPAISIPQVVASKPTPPKPSWALAADSADPRSLEMLPMQRVAQLQAIYDGSPIGLCFLSRDLRYVSVNRQFAVMNGTTACALIGLTVASVYPEWYPLYEPYLKRALAGEVLSKITVTRPARNTNEIAQDIEISYAPARDEGGEVIGICMAALDITDRQRSQVALQESEERFRMIVDLNPQAPFIMDPDGCITDFGVAFEELTGFSREEIMGRGFLEVVHPDDVARVSLVIAETISCGAAMDVEWRAQRHNGYHLWLRSRATPVFSLAGKLIHYCGSTENINHLKLLGAALKAAETILESVTAPHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F8</accession>
    <name>E8X7F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conjugation TrbI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4446</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbI/VirB10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573111.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71392">
        <property type="protein sequence ID" value="ADW71392"/>
        <property type="gene ID" value="AciX9_4446"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4446"/>
    <dbReference type="HOGENOM" id="CLU_646844_0_0_0"/>
    <dbReference type="OMA" id="GKHVPLY"/>
    <dbReference type="OrthoDB" id="1674599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16429">
        <property type="entry name" value="VirB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005498">
        <property type="entry name" value="T4SS_VirB10/TraB/TrbI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042217">
        <property type="entry name" value="T4SS_VirB10/TrbI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03743">
        <property type="entry name" value="TrbI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="44895" checksum="00D97FFAF2404B98" modified="2011-04-05" version="1">MSETPATVPSQPESNAPIKKGFPILLILVAIVLLVGIANVSHLVSGAKKPVAKSALTSSPATVNPQQVSSYQTMQATEIKRDAEDRQVLAANQAAALQAQSDLPGPEADSSAPMTAAQRQSIYGDSPNAPRHTSNASQGHAEAQQRELAHRKAQQDAINSDTVAIDFAHAGGTPAAVLGDREQATNTASGEDIGSAAERPARPATLQTVADTRNSAKGDPMAPYGFDAYQGQLYRVFEGTVLEGVVTNHIDGGFSGPILVMLTTDYYSHDHQRLLMPQGTRLIGTVQSVGSQGQRKMFVTFYRAVCPDGFSLEFDKYIGLDPIGTTGLASKVDNHYLSAFGAAAAIGGLGGLAQIGNSASVLDPSAQIRNDMSQQTAQEGEQILNHFLNRLPTITLKEGSRARVYIGRDILIPSYADHRVDPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H1</accession>
    <name>E8X7H1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4459</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573124.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71405">
        <property type="protein sequence ID" value="ADW71405"/>
        <property type="gene ID" value="AciX9_4459"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4459"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_3_0"/>
    <dbReference type="OMA" id="IDSANIY"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="22792" checksum="DEA88829BF4B2B58" modified="2011-04-05" version="1">MSRIVEPKVTKVKRRVGQVVGYLRVSSLDQKEIRQLDGITLDKRFVDKASGKDIQRPQLEHLMGYVREGDTVVCHAMDRLARNLDDLRKLVLTLTQRGVNVRFQKENLTFTGEDSPMSHLLLSVMGAFAQFERDLIRERQREGIALAKLRGGAYVGRKHSLDAAKAKELRRRVASGESKTAIAIEFGIARQTLYRYVAGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I4</accession>
    <name>E8X7I4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4472</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573137.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71418">
        <property type="protein sequence ID" value="ADW71418"/>
        <property type="gene ID" value="AciX9_4472"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4472"/>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_0"/>
    <dbReference type="OMA" id="RIHRSYT"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="27190" checksum="5062C1AE8EE1E17F" modified="2011-04-05" version="1">MKVLIVDDEPLARRGLSQALAVFDNIEVIGSASDGDQALSMIRSLIPDLVFLDIDMPGKTGIEVAAALGRNHAAEVVFVTAFDNYGEEAFSVEATDYLLKPINLERLRQAISRADRRKAERMAIPARHALPNYLTQRSFGLPNGQDLPESEIIWIEAAKDYALIHTRIRSHIVRATMSQLSERLGTLVVRVHRSALVAVQWVQGWKNYRKGASSLLLKDGTQVQVGPTYLHSTREALHGIQGEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X813</accession>
    <name>E8X813_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4667</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71597">
        <property type="protein sequence ID" value="ADW71597"/>
        <property type="gene ID" value="AciX9_4667"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4667"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_3_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="8">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23815" checksum="ABFC1CF7221F1734" modified="2011-04-05" version="1">MLQAMPKVVKPNATHHPPKGQTVGYARVSSFEQNENRQLEGMEVDRVFLDKASGKNIQRPQLEALMKFVREGDTVVCHSMDRLGRNLVDLRKTVGELTSRKIGVRFIKENLTLTGDDSPMATLLLNMMGSFAEFEVAWSRERQREGIELAKRDGVYKGRKRLLTPDRAAELTRRLGLGESKAALAREFQLDRTTVYRYIGRAKAQPEGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV64</accession>
    <name>E8WV64_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="10" type="ordered locus">AciX9_0165</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578567.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0165"/>
    <dbReference type="EnsemblBacteria" id="ADW67239">
        <property type="protein sequence ID" value="ADW67239"/>
        <property type="gene ID" value="AciX9_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0165"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_0"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="295" mass="31428" checksum="B47E617A58B59004" modified="2011-04-05" version="1">MSVTQPRTAAREPSAQKVTPQTLLDRKRSHQPITALTAYDYPSARLVDEAGIDLILVGDSLAMVALGYDSTLPITVDEMLHHARAVRRAVRHALLVVDMPFGSYHTTPEAAVANAIRFVKEAGAEAVKIEGGATRASLIEQLTRAEIPVVGHIGLTPQSLNRMGGYKVQGRSIPAIESLLADAAAIEGAGAIALVLEGIPREVAARITAAAGIPVIGIGAGPDCDGQILVFHDLFNLTFSPGAKFVRRFADAGALMREGLQHFQSAVQDHSFPNDAESYHLPIEVAEHLAETITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV79</accession>
    <name>E8WV79_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0180</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578582.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0180"/>
    <dbReference type="EnsemblBacteria" id="ADW67254">
        <property type="protein sequence ID" value="ADW67254"/>
        <property type="gene ID" value="AciX9_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0180"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="YLYCSSD"/>
    <dbReference type="OrthoDB" id="1281138at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S53" evidence="7">
        <location>
            <begin position="235"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="948" mass="96027" checksum="39B13F7A1D2C2DD0" modified="2011-04-05" version="1">MFPSFLSSLRSAASALPSRLPLQSSLLALSLLSVCGTAQTLKPRITQEINAAQRVTLAGSRNPRALAADDTGSLASGTKLEGMSVVFRRTEAQEADLQALLAAQQNPASPLYHQWLSPEQFGTRFGLSASDQAKVSAWLEQQGFTVDGVSRSGNRISFSGTAGKVGNAFGSELHNFTKDGETHFAPASEVSVPAALSDIIQDVTNLSSFRPKARVKLRPAVVDPNFTSSQSGSHFLTPKDVATIYDINAAYSAGYTGTGQSIVAVGQSAVVLSDIENFQTAAGLTVKDPTVILVPGSGSSTVKTDDESESDLDLEYSGGIAKGATIYFVYTGNNTNYGAFDALQYAITNKIAPIISVSYGTCETNFSATSFAAENAMLAQAAAQGQTVVAAAGDAGSTDCSGTTILNTTQQEALAVDFPSDSQYVTGMGGTEFPTADITSSNSTYWTASSGTDVIGSALSYIPEQVWNDDSASNGILSGGGGVSIFTPRPTWQTGVTGIPTGSFRLTPDISLDSAVVNAPYLYCSSDTATKITGSCSNGFRDSTNTNLTAAGGTSFAAPIFSGMLALINQKLNSTGQGVINPTLYTLAANSTTYARAFHDITSGTNSCTAGSTLCSTAGASAYAATTGYDQATGLGSVDLYNLLTAWPTTTGSTLLASTTTLSAVTTTPVSGAGDVITITVAPSTTSLTTSPTGTVSIAVDGATVSSSAALTSGVATYTFSSTTVGSHIVTATYSGDSIYASSTGSVTLTVGTTATGTGTILLSATNLTVTGGATGTSTITVTPGSGYTGTVSFTVLSSASLPYACYTPITNATVTGTAAVTTALTISTGSASCVGAAVVRAGGKRSLASLSPSQVPGTGESHTKIVLAGLMLFGLCGCRSRRLRKFAPVLLLAGFGLALSGCGSGSGSTTSTTNNLTAKGTYTLTIIGTDVSNALITSTTSLTLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV81</accession>
    <name>E8WV81_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0182</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0182"/>
    <dbReference type="EnsemblBacteria" id="ADW67256">
        <property type="protein sequence ID" value="ADW67256"/>
        <property type="gene ID" value="AciX9_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0182"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_1_0_0"/>
    <dbReference type="OMA" id="MTPILLW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="29215" checksum="3F5A490EC4FB4C0A" modified="2011-04-05" version="1">MEYFIGFVIAVFIALTGVGAGTITTPLLILFLGVPTTVAVSTGLMFSAAVKLVLVPSQIARKQVNWRVLGWMLLGGLPGVLLGSFVLVHLATAGSKQLMNSILGTVLVATAIYQIFYSFRPIQKDYTKPDRSRWMPLLMFPVGAEVGFSSAGAGALGTAALLSLTDLLPAQVVGTDILFGFMLSLVGSGAHWFSHSTNPSLLMHLVIGGIGGVIVGTASAKFIPKRPLRFALWVWLLVIGSQVLYTSGGPQALAHKSYNLCKVAWSNLPLKASAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV96</accession>
    <name>E8WV96_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0197</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578599.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0197"/>
    <dbReference type="EnsemblBacteria" id="ADW67271">
        <property type="protein sequence ID" value="ADW67271"/>
        <property type="gene ID" value="AciX9_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0197"/>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106694_1_0_0"/>
    <dbReference type="OMA" id="VFMGVEN"/>
    <dbReference type="OrthoDB" id="1232828at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="20173" checksum="A29CFE10691611B3" modified="2011-04-05" version="1">MATTFSGPAPSDDVLARARKIKLFLMDVDGTLTDGGVGLISSLAATDGAEAVVTELKMFSAQDGQGLSLAHTMGIKTGFITGRRSPAVAQRAKELKVSYVCLGQGNKKAAYEDCMLKAGVTEEEVCYLGDDLPDIPVARRSGLGVCVGDGVPELMAVCHYTTGKGGGKGAAREVVELILKAQGRWDEAVPLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC3</accession>
    <name>E8WVC3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0224</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578626.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0224"/>
    <dbReference type="EnsemblBacteria" id="ADW67298">
        <property type="protein sequence ID" value="ADW67298"/>
        <property type="gene ID" value="AciX9_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0224"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_0"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_3" evidence="5">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="204"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="423" mass="45816" checksum="00D1809AC14D7FD7" modified="2011-04-05" version="1">MAKPQDLRPIRVGTPHPQGPAAIITRRASDKIRAGHLWVYRTDVEQLLPAPGTTSVDPGALVTILDTRGIPLGSALYSSASQITLRVVSPLAALTREAYLAETRTRIQAALSLRNQLSPVTADNNAHRLIFAEADNLPGIVADRYNDLIVLQLLTQSTAKPDLRALIGEVLAAELHPSTILERPDPRVREIEQIAPAPTEPIFSAGEAKEATIFTINGLHFAFDVTSGQKTGAFLDQRLNYAAAARYAHGRALDVCTYQGGFALHLAQTCDRVTGVDTSRAALEVADANLALNPHLKARTDWMEADAFDLLREYESTGERFDTIVLDPPAFAKSQRALEGALRGYKELNLRALKMLNPGGTLVTCSCSHHVPLEEFTAVVASAAADSHRRVQLLETRGAAPDHPAVLTLPETSYLKCLVARVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH8</accession>
    <name>E8WVH8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1366</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579749.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1366"/>
    <dbReference type="EnsemblBacteria" id="ADW68426">
        <property type="protein sequence ID" value="ADW68426"/>
        <property type="gene ID" value="AciX9_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1366"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012501_0_0_0"/>
    <dbReference type="OMA" id="SENYGHH"/>
    <dbReference type="OrthoDB" id="1281138at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230347" evidence="7">
        <location>
            <begin position="36"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="221"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="934" mass="97030" checksum="47C2BCA985BDE944" modified="2011-04-05" version="1">MSHFASTLPVLTSTRRLMVGASMAASFVLSSPAFAQNAVISQHVPAVVRSGVAPRLQPLTSFTTMELQLTLPIRNEAALDAELADIYNPASPKFHQYLTSAEFDRKYAPTEADYQTLIRWAHNKGFAVTLTTPNRRLISVSATTDVVNRAFNVTETEFRDNVLARTFHAPDREPTTDLPIRLFAISGLDDSIPKHNHLKQGTRAQRSAATHLITGSGPQNTYLPSDMRAAYYGTGPLDGTGQTVAIYSYDGYLTSDLSVFATNTGTPDLTAKVKNVLVGGYAGKCFASSSGTSGTCDDGEQILDIEQVGGMAPGIKQILFYEGTSAVAELNQMATDNLATVITSSWGGGDFGPANDTTFKQMAAQGQTFMNATGDSGALNSSTYSAPSVDPYILEVGGTDLVTSGAGGAWVSEDSWSSSTGGFFSASSPIPSWQQTPGVITTANQGSTTLRNVPDISAEADFDNPTVTNGSFQLGYGGTSFAAPRIAGLIALANQQSAAQGGKPVGFFNPALYALGLGATAAANLHDITNGANPSQVGTAVSFNAVPGYDLVTGWGSPNGATFLNSLVSSLLPDFSMALSANTVTMVRGTTDPANSINLAITSLQGFTSAVNLTVSGLPANVTASFSPATATTSSVLTFTADPTVQSSTSAITVTGTSGALTHSYTLTLNVLKRASGDFTMSLGNTNVALIPGGKSGLNAVTITPGANFVNPLTLSLSALPPSTVGATFTTNPTLASSNLTLAAAAAAPLGTFPMTVSATNGTLLHSVPFNLILTNAQLLGNPGFENGTDTTPWIATGGIECNTACTPQAPNSGSYFLWMDGYGKVHTDYAYQTVTVPSGYSSLVLSFALHINTVETTTTLKNDVFTVQILDPNGVVLATPFTFSNLDAATGYIVHTANLSPYSGQTITLKFMGVENKSLATSFTLDDVSLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN0</accession>
    <name>E8WVN0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alternate F1F0 ATPase, F1 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2529</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580874.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2529"/>
    <dbReference type="EnsemblBacteria" id="ADW69559">
        <property type="protein sequence ID" value="ADW69559"/>
        <property type="gene ID" value="AciX9_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2529"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_1_0_0"/>
    <dbReference type="OMA" id="DYYRTVQ"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017709">
        <property type="entry name" value="Alt_ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03323">
        <property type="entry name" value="alt_F1F0_F1_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="33753" checksum="6D12F62E146C9980" modified="2011-04-05" version="1">MSGSTEQLSRKISGAKDLGGVVRAMKALAASSVGQYEKAVNALDDYLHTVELGLIACLHRASKGFPAIDIKPQHADKIGAVIFGSDQGLVGSFNEVIVEFSQKSLRALAGRVTQIWVVGDRAKALLAETGGIPVRGLEVPASLDAITPLVGQILLELEAAREKGEIWEVHVFHNHPKPSSAYEPVGRWLLPLDAAWEQKLHATPWPTKTPPQVIDGVSSAFPILIRDYLFVLLFQACAESLASENASRLASMSRAEKSIDSMLDDLNRKYHRLRQESIDEELFDVIAGFEALTRKKPKPSSDTSLAKTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN2</accession>
    <name>E8WVN2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="12" type="ordered locus">AciX9_2531</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580876.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2531"/>
    <dbReference type="EnsemblBacteria" id="ADW69561">
        <property type="protein sequence ID" value="ADW69561"/>
        <property type="gene ID" value="AciX9_2531"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2531"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070737_0_0_0"/>
    <dbReference type="OMA" id="DWFTVIA"/>
    <dbReference type="OrthoDB" id="1456190at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017707">
        <property type="entry name" value="Alt_ATP_synth_F0_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03321">
        <property type="entry name" value="alt_F1F0_F0_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="29151" checksum="90655EACE7AC775D" modified="2011-04-05" version="1">MLIDWFTVIAQMLNFLILVWLLKHFLYQPILNAIDTREKGIASKLADAEAKEADAHKQQEDFESKNKTFDEQRAALMTKADSDAKAEHDRLIGDAHKEADGVRASEAAALKDDQAHQTVAIRRMAQDQVFAITKKTLADLATVTLEERIGEVFTRRLREMNAKDKEEMGAALKSSPEASLLRSAFNLPDQQRAAIQNALNETFSAVIRVRYETDANAISGIELTAQGQKLSWSISSYLDSFDRSLAELTSQGTKPAPVTEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR5</accession>
    <name>E8WVR5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2567"/>
    <dbReference type="EnsemblBacteria" id="ADW69594">
        <property type="protein sequence ID" value="ADW69594"/>
        <property type="gene ID" value="AciX9_2567"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2567"/>
    <dbReference type="eggNOG" id="ENOG5032TZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075807_0_0_0"/>
    <dbReference type="OMA" id="GFAPTYW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="25874" checksum="090A6F6F864F25B3" modified="2011-04-05" version="1">MYDTSIVDHCFYTGMAFAMAAGVFAGFMKTYYAKTYFHSPAIPFWVHVHGAIFTGWILFYLLQNLLAMYGRMKLHRSLGIVGGLLATGVVVFGSAIALRQARQGRFFPFPDGYSLLAVSFGQMALFAIFVYFGLRLRRDAETHKRLILMSTQLFFFPAFGRLLHGINPLTLGIALCFYFAGPIYDLLSRGSIHRAYRWGVPLLVATMPPFAVIASHVNAWRYVVDKWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ0</accession>
    <name>E8WVZ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3749</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582057.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3749"/>
    <dbReference type="EnsemblBacteria" id="ADW70749">
        <property type="protein sequence ID" value="ADW70749"/>
        <property type="gene ID" value="AciX9_3749"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3749"/>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_2_0"/>
    <dbReference type="OMA" id="AYVNCLA"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="35173" checksum="97ACDEFDE52C8BCB" modified="2011-04-05" version="1">MIVPKAANLPRMIQYVGLPLLALVVWDVCIVVAYKVLHWEWVGSRNVPLALYGSAIGIIVGFRNNSAYARWWEARGLWGQIVNNSRSFARQVFSTLRPDHIESEHDEDELLTTRHTLIYHQIAYVHALRQQLRGLDPFPEIHGLIPEAEYQSLALQKNVALALQRNMGTIVRNARQRGWIDNLEWQAMDKNLDDLADAQGGTERIKNTPMPKQYDFFPMLFVQIYCILLPIGMVEQLGWFTPLGSTLVGFMFLTLDKIGRDLEDPFDNEIYDVPLTSITRTIEINLRQILGETELPPPVTPERGVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ3</accession>
    <name>E8WVZ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3752</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582060.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3752"/>
    <dbReference type="EnsemblBacteria" id="ADW70752">
        <property type="protein sequence ID" value="ADW70752"/>
        <property type="gene ID" value="AciX9_3752"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3752"/>
    <dbReference type="HOGENOM" id="CLU_2493547_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9521" checksum="B1800B8D7A26FBD4" modified="2011-04-05" version="1">MSDVISGVRQVVQDIVAPDLKALTAKVDALKTQSAIEHDAVMKTLDAFRAEMRSELAALRANNQVEVYRQVAPISERIAIMEARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ4</accession>
    <name>E8WVZ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3753</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582061.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3753"/>
    <dbReference type="EnsemblBacteria" id="ADW70753">
        <property type="protein sequence ID" value="ADW70753"/>
        <property type="gene ID" value="AciX9_3753"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3753"/>
    <dbReference type="eggNOG" id="COG3558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112790_0_0_0"/>
    <dbReference type="OMA" id="VRFQYEC"/>
    <dbReference type="OrthoDB" id="1650155at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="18269" checksum="F231EF466DB4810E" modified="2011-04-05" version="1">MSDALVLVPPFTMETAKAKVRKAEDGWNSRNPAQVSLAYTVDSKWRNRAEFVNGREEIVAFLTGKWEREQEYRLIKELWGFKENRMAVRFCYEWHDAEGQWFRSYGNELWEFDEVGLMRVRHASINDLAIAEGDRLFFWPQGPRPVDHAGLSELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW42</accession>
    <name>E8WW42_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0276</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578676.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0276"/>
    <dbReference type="EnsemblBacteria" id="ADW67348">
        <property type="protein sequence ID" value="ADW67348"/>
        <property type="gene ID" value="AciX9_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0276"/>
    <dbReference type="HOGENOM" id="CLU_1007472_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="31225" checksum="D9D76E06CF5F7E7B" modified="2011-04-05" version="1">MGIDTMHETAAQYRLLYMQPDPEVGENICVAVMFGDDLLFDPTFSKVKCLTREWRPGLLRLYMNEIRMTLLRDTSNFEVSIKRFAPLFSASRPRYLATPVAPETKVALYQAYVANRSTLDAAARRRESFVEHVNRFVTARELPPSTEVIANATGREVLGRTKVSVRPVALALKGLAQTVLVDGIDLNLDSAKIAIQQAGRITHTFWQYRLYGAEQNKNIKRVALVFNGNSHKKADLRDAHDFAFQQFQTESDIVIDAASEDADRQVQGFLEHYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW59</accession>
    <name>E8WW59_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0293</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578693.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0293"/>
    <dbReference type="EnsemblBacteria" id="ADW67365">
        <property type="protein sequence ID" value="ADW67365"/>
        <property type="gene ID" value="AciX9_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0293"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586314_0_0_0"/>
    <dbReference type="OMA" id="PFFISAW"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="350"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="466" mass="51599" checksum="D5151BBD1664F13B" modified="2011-04-05" version="1">MSMDAGTKKRLILGLISNWISKLAGSVIQFVQVFVFLKYWSEPLYGEWLIINSIPSYLSFSNIGFGSVAGNEMTMAVARDDRESALRAFQSCWWMITVALTVTGLVVGVLLYQLPVGRLFHLHEISDSDTKWIIAYLGFSVLLGQLEQLLQSAYRCVRRYPYGSFVKSCMSLAAFAVMLVPVLRHQGPRTVALWFAVANVLGTVILALMVRHDIPWISFGWKHASFAEIKKMSLPALAFMGFPMGNALNLQGTLMAVSYALGPVAVVVFSTARTMSRVALQMVQMINSSFEPEFSKSYAQKDIALVRTLHRRACQMAIILALGVIAVMILGGPWALNHWTHGKVPPSRELLSILLLVVVFYALWSTSSGVMYATNQHQKLAAVYLGGTAATVALTYFVAQWYGLYGAAASLLLSELVMNFYVLPATLRIAHDTFPAFLASMFDVPPALHPRTWLRKLSRSHPGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW76</accession>
    <name>E8WW76_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1400</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579781.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1400"/>
    <dbReference type="EnsemblBacteria" id="ADW68459">
        <property type="protein sequence ID" value="ADW68459"/>
        <property type="gene ID" value="AciX9_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1400"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="582" mass="64652" checksum="1E8640C40AFA7828" modified="2011-04-05" version="1">MPDRLKPLVPYLKRYWKHLAWGGVAVIIYNFVKAMLPIVIGHAVDDLKIEVTTTKIIHHSLLLLAVAATSAVFLYITRQVLIGASREIEFDLRNDLFANLERQSPAFYQTHRTGDIMARTTNDLSAVRQLLGPAIMYSANTIFFTAASLPFMFRISPRLTFFAFVPLPLASLLVQQFGARIHKRFERIQAMFSDISAKAQENFSGARLIRAFAQEDAEIASFEAANQENVNRSLHLVRLMAMLWPTLEFVLGLSLMITLLVGGHEVVLHHISVGQFTEFMVYMVQLTWPMIAIGWVVNLFQRGTASVIRIDEILKQKPDIADDPALIREQPAFAGEIEFRNLNFAYNPGTPVLHNINLRIPAGTSLAIVGPTGSGKSTLVNLIPRLYDSADGSVLVDGLPIRGFPLKTLRGNVGVVPQETFLFSDSIHHNITFGAPDATLQQVEDAATVAHIRTEILEFPKSFETLVGERGVTLSGGQKQRTAIARAVIRDPRILILDDALASVDTYTEERILSGLRGVMQGRTTILISHRTSTARNADQIAVLVEGRIAELGTHDELLARGGYYTHLYEKQQLEEELAVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC3</accession>
    <name>E8WWC3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579827.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1453"/>
    <dbReference type="EnsemblBacteria" id="ADW68506">
        <property type="protein sequence ID" value="ADW68506"/>
        <property type="gene ID" value="AciX9_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1453"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_0_0"/>
    <dbReference type="OMA" id="MAVQATN"/>
    <dbReference type="OrthoDB" id="1204683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="21984" checksum="2B2BB1CED9F6D071" modified="2011-04-05" version="1">MKTANGKTGRPISFDKNAALEAAMLLFWERGFEGTSMADLTQAMGLNPSSIYAAFGDKHALFSNAVKRYLETRTQYATDALGEPTLEKAVRALFHNTIAFLTTPGHPSTCMTLAGAMGCSVDATPARDLMTEIRRHNEVEMKDRFLEARKSGELTKDINVDDYTRYISMMVAGLSVQAANGSTKTELKRTAELALHYLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU2</accession>
    <name>E8WWU2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0348</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578748.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0348"/>
    <dbReference type="EnsemblBacteria" id="ADW67420">
        <property type="protein sequence ID" value="ADW67420"/>
        <property type="gene ID" value="AciX9_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0348"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_6_0_0"/>
    <dbReference type="OMA" id="IAINGCT"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="PTHR11530"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="5">
        <location>
            <begin position="114"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="43932" checksum="88D81793D4938CAB" modified="2011-04-05" version="1">MNRRQFLHSSAAAAAALTATGCHPKPILAKASTPTLPPYDTLPYLAPIRAHTDRLFRITVCIRPFRAEGPRIEPERVGDKLVIHHYGHGGSGWSLSWGSAALVVPMAMADGQRDIAVIGCGAIGLTTAAMLQRAGARVTIYAKERPPYVRSSRATGSWTPDSRVALTANAAPDFAAKWEKMARTSWAMYQQFLGASGTPVEYSDRYALSALHPDAAIAKKEREDPIGFARYNHLLDDLTPKPVDYGPGEHPWPKEHCRRFTSLQFNIADYSRQLITDFQLAGGKIETCEFHTPADFAALPQKVIVNCTGYGARALFNDNSITPVRGQIGWLIPQPEVNYGIYYENLNILSRRDGIVVQSSEQGEASGWNDTNEQPDRREAEDAVRLLATIYAGMKPQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU5</accession>
    <name>E8WWU5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0351</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578751.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0351"/>
    <dbReference type="EnsemblBacteria" id="ADW67423">
        <property type="protein sequence ID" value="ADW67423"/>
        <property type="gene ID" value="AciX9_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0351"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028527_0_0_0"/>
    <dbReference type="OMA" id="PGHYVQF"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234114" evidence="1">
        <location>
            <begin position="26"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="592" mass="65240" checksum="0592134F7BBEC69F" modified="2011-04-05" version="1">MRHLPRIILLAAAATATLFPTLAPAQRVSADGSPQTFTFLANNFLSEALYPFSPTAGTGAGLHEYDTRLEDYSPATIAKQIAIYRSYEKKISAIDGSALDAPVAADREILLSSIRSTLLTLETIRPFATNPDNYSSGITASAFSIMERPYAPANTRLRALVEREKLMPALLQEARTNLKNPPHIYTEIAIEQVDGNISFFQNDVPSAFADATDPEVKAAFAKSNAAVIAALKDYAAWMKSDLLPRSNGDYKLGTDTYRKKLAYDEMVDIPLDRLLEIATADLHKNQAEFARIAKEIDPSKTPQQVLAELATIHPAPDQLLNTFRDQFSSLIAFINTHHIITIPSKVEPTLEETPPFMRATTQASMDPPGPFETHSTKAYFNVTLPEKDWTPAHIAEHMAAFNVGTVTSTAVHEAYPGHYVQFLWMPQFSSPIRKVFGASTNIEGWAHYCEQMMLDEGYLPPGTVAGSKEAKLIRLGQLQDALLRDARFVVSIRLHTGVGGALTIAQAAELFVKEGYQSPSIGMIETKRGTSDAMYLYYTLGKLQIMKLRADLQAQQGSSFSLQAFHDSLMRQGFAPIKVVRKAMLHNDSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX7</accession>
    <name>E8WWX7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="15" type="ordered locus">AciX9_1485</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579858.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1485"/>
    <dbReference type="EnsemblBacteria" id="ADW68538">
        <property type="protein sequence ID" value="ADW68538"/>
        <property type="gene ID" value="AciX9_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1485"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_1_0"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="34"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="736"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="zf-FPG_IleRS" evidence="13">
        <location>
            <begin position="950"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="653"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="954"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="971"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="974"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111964" checksum="835B6AA3F084840A" modified="2011-04-05" version="1">MSDVPQKKPLKATLNLPETAFAMKANLPQNEPARLEAWQKAGLYEQIRTARAGAPKFILHDGPPYANGAIHLGHALNKCIKDFVVKTKTMAGFDAPYVPGWDCHGLPIEIKVDEQLGRKKLEMPALSVRRACREYAEKYVTLQKSQFERIGVFGRWNDPYKTMSFGYEAAIVETFYEFFEQGFVYKGLKPVFWCIHDQTALAEAEVEYEMHTSPSIYVRYKLTSEASAISEKLAGKDVWTIIWTTTPWTIPASMAVAYNPEMEYVAAQATLASGEIGVYVVAGTLLEAVAKACGFTDVEVLERFNGIRMEGAQFAHPFFARTVVGVTADYVTADQGTGAVHTSPAHGVDDFYTGKRYGIPDVQYVDNAGRQRNLPQQEAFDGLTVFESNKPITELLREKGALLSGTFFEHSYPHCWRCHNPVIVRATEQWFISMETPMPTAEAEIAAAEEVDGSEPTSQKRDVEHPVVDGMTTFRQRALDEIKRVVWDPAWGEERISNMIATRPDWCISRQRIWGVPIAVFLCNKCHEPLNDADVNKSIVELFKKESADAWYKYSAAELLPDGVACSCGNTDKNEFRKEMDILDVWFESGASWHAVLDAEESLRFPADLYTEGGDQHRGWFHSSLLTSVALRGVAPYRMVATSGWTLDEQGRAFSKSLGNGVDPVDVAKRLGAEIIRLWVASVDFREDVAASENLMQRVGDNYRKLRNTLKFLLGNLHDFDPAKDALPFADLEQLDQYILAQTAELVAKIRKAYDEFEFHRAYHALNEFVNTDLSALYLDVLKDRLYTFAPDHPERRSAQTALWRIAEALVRLIAPILSFTADEAWAFLPKVEGRESSVHLALFPDLSDIVPGSEAAIEHDWEQLLELRAQVMAKLEVLRAAKSIGKSLEAKVTLTVVIGPGPSPLRLLDQYTTALAELFNVSEVDVLFVESALETPSFEIEVQRSAAPKCERCWRYIPEVGEDDRFPTVCLRCADALEAIGFEPYQIPPQDAAGEGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY1</accession>
    <name>E8WWY1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1489</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579862.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1489"/>
    <dbReference type="EnsemblBacteria" id="ADW68542">
        <property type="protein sequence ID" value="ADW68542"/>
        <property type="gene ID" value="AciX9_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1489"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_0"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="37445" checksum="36E26C1D440AB7F5" modified="2011-04-05" version="1">MPETAQPVFQTERLDARNPAAILRAAAILRAGGTVAFPTETVYGLGANALDPTAVAKIFEAKQRPSWDPLIVHIANQQMLAEIATLDQQGTAARLIDAFWPGPLTLLLPRTQAIPDAVTASRPLVGVRMPAHPVALELIRQTGLPIAAPSANTFSHTSPTTAAHVLADLDGRIDAILDGGPTTVGLESTVAEITPDGLIVYRPGAVTLDMLNNLLGQGTAHLHIPPERSSPIESLPSPGVGIRHYAPKARVLLIDSPEDCAANWDLFIENLRQVDDKLGLMLPDNWPAPEHASIFRWGSWSDKETLAHRLFSGLRALDDEHVTHIICPLPSPEGMGAAIRDRLQKAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX42</accession>
    <name>E8WX42_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2660</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2660"/>
    <dbReference type="EnsemblBacteria" id="ADW69684">
        <property type="protein sequence ID" value="ADW69684"/>
        <property type="gene ID" value="AciX9_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2660"/>
    <dbReference type="eggNOG" id="COG3258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058582_2_0_0"/>
    <dbReference type="OMA" id="IYENMPF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="183"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="30044" checksum="6CECBC94773AF4AD" modified="2011-04-05" version="1">MKRVRERWIVVAVVALTVSVYGGAILASLLPKHLSLDLDATTRQSKLPWRPPPVSSIPDNPHGDSIRRGALLFDETPLYAAAFTGAKVSCANCHAEGGIQPLASPVVGLPAKFPMYNERAGHMISLKDRVQECFVRSENGTPLDYDGTEMKGLVDYIEWLSIPQPGRRAFEGRGLVKLPELTPDPIHGGQIFAAQCAGCHGEDGQGKPPKFPPVWGPQSFNDGAGMHGVRKMASFVQHNMPQNRMGILTPQEAWDVSAFIHAQPRPAFNTAYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX43</accession>
    <name>E8WX43_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581000.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2661"/>
    <dbReference type="EnsemblBacteria" id="ADW69685">
        <property type="protein sequence ID" value="ADW69685"/>
        <property type="gene ID" value="AciX9_2661"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2661"/>
    <dbReference type="eggNOG" id="COG4272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140339_0_0_0"/>
    <dbReference type="OMA" id="EKDYMYV"/>
    <dbReference type="OrthoDB" id="1914673at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="13645" checksum="470ABE3C4357B978" modified="2011-04-05" version="1">MAKAPKPLNCTVIDAQIGLLLRIGLLCATLVVMAGGAIFLAAHQHSVVSFHTFHGEPASLKSPLLIVEGVLHGQALAIIQFGILLLIATPVARVVFSIFAFLKARDYLYGMIAGMVLLVLLYSLIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX47</accession>
    <name>E8WX47_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2665</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2665"/>
    <dbReference type="EnsemblBacteria" id="ADW69689">
        <property type="protein sequence ID" value="ADW69689"/>
        <property type="gene ID" value="AciX9_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2665"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_0"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="5">
        <location>
            <begin position="365"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="480" mass="51154" checksum="C7FE2A4E7347814E" modified="2011-04-05" version="1">MTGGSAGRTLTCMSAPLADPVEHYDLLVLGSGEAGKYIAWAMATSGKKAAVIERRYIGGSCPNIACLPSKNFVHSAKVAHYASQAAQFRLPVATGPIDMEVVRGRKRKMVDGLVQMHEGRFAQTGAELILGTGTFTAPRTLHVLTNTGMTRMLTAETVVISTGSRAAIDPIPGLLEAQPLTHIEMLETGQVPPHLTILGGGYIGLEFAQAMRRLGSEVTVVERNPRLLHREDEDVITTLTGVLSREGIEILTSTSVERVTGRSGSSVTVHTSAGEITGTHILVATGRTPNTDGIGLDLAGVTLGKDGHIQVDEHLRTSAENVFAVGDCAGSPHFTHIAFDDHRVVKSVLLGKSGSTPRSTKDRQVPFCLFTDPEFAHIGLSESEAKRQGISYRLAKLPMLAVLRTRTMDESEGFLKALISTQDDSILGFTAVGVGSGEMLAAVQLAMSANLPYTALRDLIVTHPTLNEGLVYLFSSTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX50</accession>
    <name>E8WX50_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2668"/>
    <dbReference type="EnsemblBacteria" id="ADW69692">
        <property type="protein sequence ID" value="ADW69692"/>
        <property type="gene ID" value="AciX9_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2668"/>
    <dbReference type="HOGENOM" id="CLU_1956514_0_0_0"/>
    <dbReference type="OrthoDB" id="2222247at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="15396" checksum="86986DB6DA135921" modified="2011-04-05" version="1">MQLLVDEPWKDELWYQNQWRAFYRERMRKLSRLGVIFGTIGIGALLFGVIPSTSLEHHPFLSDSAALLGGLLWLTLLIQWFRMNWQMTSWDCPRCNELYFKRNPFRHRCAHCKLRRPRQREVSPLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB8</accession>
    <name>E8WXB8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578779.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0379"/>
    <dbReference type="EnsemblBacteria" id="ADW67451">
        <property type="protein sequence ID" value="ADW67451"/>
        <property type="gene ID" value="AciX9_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0379"/>
    <dbReference type="eggNOG" id="ENOG5032SDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121854_0_0_0"/>
    <dbReference type="OMA" id="VERTGCK"/>
    <dbReference type="OrthoDB" id="1845862at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039437">
        <property type="entry name" value="Put_lumazine-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12893">
        <property type="entry name" value="Lumazine_bd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234134" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15897" checksum="637E711532CE36FD" modified="2011-04-05" version="1">MKLLPVLLLAAIPALLPAQTPDERAVLTPVDALFVGMAHRDAAAIKAAFIPGATLVLMRDGKPSQMTFEAFAERIGKPSTTQIEERIHDPLIRVDHDLAVVWAPFDFLANGKVDHCGTDLFNLVRVDGKWLIASVADTGSNTCGVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY32</accession>
    <name>E8WY32_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0499</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578899.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0499"/>
    <dbReference type="EnsemblBacteria" id="ADW67571">
        <property type="protein sequence ID" value="ADW67571"/>
        <property type="gene ID" value="AciX9_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0499"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_23_0_0"/>
    <dbReference type="OMA" id="VQTTVAY"/>
    <dbReference type="OrthoDB" id="1210653at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="417" mass="44542" checksum="1A06A8BFAB180746" modified="2011-04-05" version="1">MTNVPNSNLEASGAKTRAPLPFLGLACAVGVSSIYYNQPLLLEMARTFNTTPAHIGLVAMATQIGYAVGLLFFVPLGDVVERRALMMRMYAGVAIALVLVALAPTLPLLVVASALTGIMASVTHIVLPLAPDLVSDAERGKAIGIVMTGLLLGILLARTFSGWVSKIHGWQLVFLVAAAINLMFVPLLWKKMPKLPPKQSLKYSEAMLSLWNLFKTQPLLRESSLIGALAFASFSCFWTTLVFLLESHYKMGAGVAGTFGVVGAAGALIAPVAGRLSDKHGPRWVLTVGIITLASSYVIIGGGELAHLPLWVHLAILVVGVVVLDTGAQMTQVANQTRIFGLVPSARSRLNTVYMTVYFGGAALGSWLSSRVWDRWHWNGVCLTALGFMALAGLRHATGVKDEARHPKTADDAVLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY43</accession>
    <name>E8WY43_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c-type biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1617</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Possible subunit of a heme lyase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CcmH/CycL/Ccl2/NrfF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1617"/>
    <dbReference type="EnsemblBacteria" id="ADW68670">
        <property type="protein sequence ID" value="ADW68670"/>
        <property type="gene ID" value="AciX9_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1617"/>
    <dbReference type="eggNOG" id="COG3088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651322_0_0_0"/>
    <dbReference type="OMA" id="LLECNHV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005616">
        <property type="entry name" value="CcmH/CycL/Ccl2/NrfF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038297">
        <property type="entry name" value="CcmH/CycL/NrfF/Ccl2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03918">
        <property type="entry name" value="CcmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="15983" checksum="73843CACC09757E5" modified="2011-04-05" version="1">MVCLLAVVMLGAAPSSDPSARFGRIGHNMMCVCGCGQVLLECNHVGCPDSSRMIGELRDQLAGPNGTGADSLVLNWFVGKYGATVLAAPIRGGFDNVAWAIPVAMFLIATVGTGFLVRAWSQKRSGVVMAGGGASLPVDDALRERIRRETEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB0</accession>
    <name>E8WYB0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="9">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1688</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1688"/>
    <dbReference type="EnsemblBacteria" id="ADW68737">
        <property type="protein sequence ID" value="ADW68737"/>
        <property type="gene ID" value="AciX9_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1688"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_0_0"/>
    <dbReference type="OMA" id="SCGESWH"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="109"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="361" mass="40288" checksum="D2F26E20AE6596C5" modified="2011-04-05" version="1">MTPATLTPESEATSTKPGSYAEFQAQAIETGEANEAALEAQIQDMSNAKPAMAADKVRAQVKQDLRLGREHQQGRINWITTIAMGAFHVFALVALLPIFWSWKNVSVFFVMYFLAINVGIGVAYHRLLTHRGFRTPKWVEYFVTACGTMALEGGPIFWVATHRVHHQNSDQEGDPHTPVDGTFWSHAGWILSGRAMHSETALLGRYAPDLTKDKVHVLLSKYHWVLLTATGVAQLALGAFLAAPGHRVIGAVGMMLWGTMLRVVVGLHATWFVNSATHLYGARRFDTRDDSRNNWWVAILTGGEGWHNNHHAHPVSARHGLAWYEFDINYYCIWILSKIGLAKKVQIAKFDWENPKPAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE8</accession>
    <name>E8WYE8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdsB</name>
        <name evidence="3" type="ordered locus">AciX9_2831</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581169.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2831"/>
    <dbReference type="EnsemblBacteria" id="ADW69854">
        <property type="protein sequence ID" value="ADW69854"/>
        <property type="gene ID" value="AciX9_2831"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2831"/>
    <dbReference type="eggNOG" id="COG1212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065038_0_1_0"/>
    <dbReference type="OMA" id="FMATCAK"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26497" checksum="10252A4CBE981DC6" modified="2011-04-05" version="1">MSRTLAVIPARLASTRLPRKVLREIAGRPMLAWVYDAARACPQLDEVLIATDSEEVAALCHKHSWPVLMTSPELPSGSDRVHAAAQVHTADIYVNIQADEPLLHPSHITALLTPFADPSVEVTTLKVLCTPENLTNPNAVKVVTALDHRALYFSRATIPYDRDQAHPPIYKHIGLYGYRAAALNRFHALAPSPLEQAERLEQLRFLENGIPVHVALTEHDTIGVDTEEDLAAVEHLLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI7</accession>
    <name>E8WYI7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0513</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0513"/>
    <dbReference type="EnsemblBacteria" id="ADW67585">
        <property type="protein sequence ID" value="ADW67585"/>
        <property type="gene ID" value="AciX9_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0513"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="78"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="41905" checksum="09D6712B5FC28444" modified="2011-04-05" version="1">MAHDRCKQPMPLHLRISRNLGTLILEGAIAFCSASLLAQAPLPSEPELKALAGLPHYAPPQQIAGTIRVWGHGAPGLDFMGMLFKAWVDGFAKFQPNIKFEYDMYGTASAMGALYAGKGDIAILGQEIYPFETVAFNRVKHYSPTEIEIATGSVDVRNFDFAIGTFVNSKNPLTRLTLPQLNRIFAFQDTPAENIVTWGQLGLTGDWADKPIHLYGWHQDDVFSTFVQFRALDGNHRWRCEMKQYRHIHNADGTIYDSGQQILDDLAKDPYGMALSNVRYLKGIARDATKPLALARNADGPYYEATKATLIDRQYPLGRIIPAEIDRKPGRPVDPAVKEFLTYLLSREGQGEIVRNGKYLPMQPAIASRQLEKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ8</accession>
    <name>E8WYQ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580063.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1695"/>
    <dbReference type="EnsemblBacteria" id="ADW68744">
        <property type="protein sequence ID" value="ADW68744"/>
        <property type="gene ID" value="AciX9_1695"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1695"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_2_0"/>
    <dbReference type="OMA" id="IDHYKDA"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="17642" checksum="162DBF199FD575CC" modified="2011-04-05" version="1">MIGLRSNLEGAETSESGLTLVELIIVVAIVAVLATAALPIAKFQVKREKERELRAALWSMRDAIDHYKDAADKGGIQTKADSFNYPPDLQTMVDGVDVQTKKVRFLRKIPLDPMTGTADWATQSMQDDPADANGGGGGSGSGDNVFDVHSKSTGTGLDGTKYATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ52</accession>
    <name>E8WZ52_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0583</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578982.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0583"/>
    <dbReference type="EnsemblBacteria" id="ADW67654">
        <property type="protein sequence ID" value="ADW67654"/>
        <property type="gene ID" value="AciX9_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0583"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_0_0"/>
    <dbReference type="OMA" id="PSAYFYH"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="33256" checksum="6F9F70199D5E03E6" modified="2011-04-05" version="1">MRTPSSLPLISIVTPSLNQAAFLGEAVESVRTQAYPAYQHIVLDGGSSDGSVEILREAGANACLQWRSHPDGGQSAALNEGFQKAEGEIIGWLNADDRYRPGCFEAVTRAFAEHPETDVLYGDYTFMDEAGRHLELRREIEFSHFILKYCHTLYIPTTSTFFRRRVFDEGHFLKNELHYAMDLEFFMRLAEAGYRFRHLPEVLADFRMHAASKSTQFVDRQRLEHRQVVLQATPLAQHIQPMWARNVAATLLQFPADALRYTEKLLRGFYFDREVRDIAIPSQSLEVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA3</accession>
    <name>E8WZA3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S45 penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0634</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579033.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0634"/>
    <dbReference type="MEROPS" id="S45.002"/>
    <dbReference type="EnsemblBacteria" id="ADW67705">
        <property type="protein sequence ID" value="ADW67705"/>
        <property type="gene ID" value="AciX9_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0634"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021155_0_0_0"/>
    <dbReference type="OMA" id="AVTWGQF"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234191" evidence="6">
        <location>
            <begin position="23"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="727" mass="81114" checksum="BF5E90EA0FB165D2" modified="2011-04-05" version="1">MNQGSRLALLALIAALTLPAGAAVPNREEQARWSREAAAVQIVRDDWGIAHVHGKTDADAVFGMIYAQAEDDFNRVESNYLDSLGRRAESEGESKIYQDLRQKLFIDPEALKKEYAASPQWLQQLMNAWADGLNFYLAKHPEVKPKVIQRFEPWMALSFTEGSIGGDIERVDLKKLEAFYTHKPLVAEVVNPKEEPEPKGSNGFAIAPSNSASHHALLWINPHTSFFFRSELQMTSDQGLNAYGAVTWGQIFIYQGFNDRAGWMHTSSNVDAVDEYLESIHGTEGHYTYIYAGTEHPVTQRQITVPYATPQGPAQKTFTALYTSHGPIIREENGKWVSIQLMQEHIKALEQSYTRTKARNYQQYLQTMELKANSSNNTIFADADGDIAYWHGNYIPRRDPRFNYTHPVDGTDPATDWHGLLTVAETPHLLNPASGFLFNVNNWPWAGAGSSSLHQKDYPAYVEQGTETPRGLHAIRVLDGKTGFTPASLIAAAFDSYLPWFDKPIPALQAAWSALPPTDPTKSKLALQVETLRDWNHRWSSDSFATSLAVYWAEEVRAKLTPAARKAGLSVEEYSTTPAAAPILIAALNNASTQLTTDFGTWKTPWGDINRFQRLDGQIIQPFNDAKPSQAVPFTSSLWGSLASFGAKTYPGTKKRYGTNGNSFVAVVEFGDKIRARAVTAGGESGHPESKHFDDEVSRYITGDLRDIYFYPDQLKGHTERTYRPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD2</accession>
    <name>E8WZD2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS sodium solute transporter superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1772</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1772"/>
    <dbReference type="EnsemblBacteria" id="ADW68820">
        <property type="protein sequence ID" value="ADW68820"/>
        <property type="gene ID" value="AciX9_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1772"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_9_3_0"/>
    <dbReference type="OMA" id="MIFITWA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="575" mass="62185" checksum="2523D6CB5E5DE481" modified="2011-04-05" version="1">MHVVPAAFLMSGQLTHLAPVDVVILVLYFALVVFIGFYVKGSTNTSEEFFLAGREMSAWIAGLSFVSANLGSLELMGWAGAAYQYGMLATHWYWIGAIPAMLFLGIVMMPFYYISKTHSVPGYLHLRFGDGARAVSAVSFALMTILMSGVNMYAMAVVMQTVLGWNITFSIWVGAGTVALYVMLGGLRSAIINEVLQFVLIWAGAAMIPILGLVEAGGWHQLKANIATNIGNANYTHMWTTLGSFKDNPMGVHWTGIVFGLGFVISFGYWTTDFLVVQRVLSANNLRAAKMAPVIGAAFKMAVPLIVIVPGLVALGLHNADGSRMFDLVPASVAKVTGQHSFDDVLPLMLIRYCGPGLLGLGITALVAGFMSGMAGNVSAFSTVWTYDLYGAFINKKASDSHYVAMGRWSTVIGMLISIATAYLVMNANSIMDYVQALFSFFIAPLFGTVILGMLWKRATHAGGFWGLLAGTASSIGMFVWVQTNGGALRYIAMSADAKPMAENLYRALWSWIICVVVTVIVSLMTKAQPMSELSGLVYGVTPLPDDGAKNLFEKPIFWAVVVITVFFILNIVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM5</accession>
    <name>E8WZM5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581313.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69999">
        <property type="protein sequence ID" value="ADW69999"/>
        <property type="gene ID" value="AciX9_2976"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2976"/>
    <dbReference type="eggNOG" id="ENOG502ZIJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533973_0_0_0"/>
    <dbReference type="OMA" id="RMADSEP"/>
    <dbReference type="OrthoDB" id="692681at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230109" evidence="2">
        <location>
            <begin position="26"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="547" mass="59619" checksum="7FFBE9D491597EDB" modified="2011-04-05" version="1">MTVRAKFGIVFAAVAMLLGGVRAGAAKTAGPVVSIPLDSIGFQPIAAHYLLAGDTMYTLHFVDDQHLLVTFTTHGLIKRMADSEPLDYDRNVQAVLLELPSGKVLGRTEWHLRDHGQYLWPIGHGRFLLRIRNRLSLLSPMLNLAKDKPFQEEPFVTTERHIGHISVSPMNDLLTIETIPKPVEKATGAAAAMASLAAAQGRPMELQKRDAPDVQIAFFRFFVEPGKDHEEKLVAQSSGLVRARDLIEIAATSEGYLDVSQESPGVYDFDFQPHGGGKKLELSPYDSTCIPRARFISASEFVAFGCRGTEDKQQLSGFNLKGEQNWIDAFPTRHVFPYVVPAPATGRFALSRTLVAGTYVDPDNLTADMVSATEITVLQSHDGRTLLKTQAAPIQKAGQNFDLSPDGTELTVVRADAIEVYKLPALSKKDEQQIKLAGEYAPARNTARIDLGARRVAVEAEGPKETRSEKVEAKEKVVAPEGDLGAKPQAAAEALPAQTASETGKVAPASAQQQRVIMNGDEVYEPETMGHRKKPSLYDAEHPKGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU7</accession>
    <name>E8WZU7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579086.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0688"/>
    <dbReference type="EnsemblBacteria" id="ADW67758">
        <property type="protein sequence ID" value="ADW67758"/>
        <property type="gene ID" value="AciX9_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0688"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_0"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="11745" checksum="3E0D84624905EA09" modified="2011-04-05" version="1">MTDCLFCKIAAGTIPVTPIFEDDRVIAFADINPQAPTHFLVIPREHFADVTQVPAELLGHLLHAAARVAETQLPHGHRIAINTGPDGGQTVQHVHLHVLGGRPMGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X066</accession>
    <name>E8X066_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3026</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581361.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3026"/>
    <dbReference type="EnsemblBacteria" id="ADW70047">
        <property type="protein sequence ID" value="ADW70047"/>
        <property type="gene ID" value="AciX9_3026"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3026"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512647_0_0_0"/>
    <dbReference type="OMA" id="LWAITPD"/>
    <dbReference type="OrthoDB" id="1095901at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234030" evidence="5">
        <location>
            <begin position="25"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="402"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="531" mass="57274" checksum="7FC3CFFC4AD8023F" modified="2011-04-05" version="1">MIRSTFRTFLPTLFLSGITLTAFAGAQEANPTSVQAPPAAAVTQNGEVFFYKVKAVQRDIDAVNYFHRSGSTKVRFEGTNLLPNGKGEASVKSDRGGISIHAEFKGLTPANGFGPEYLTYVLWAITPDGRPQNLGEVLPDGTKNNIDVTTALQSFGLIVTAEPYFSVTTPSDVVVLKNVIIDDKTQGVLEKVNAHATLMPRGIYAEETDGAHTISHPITRDEKSPLELYEAYNAVRIAQQNGADKYSPDTMASAKQDLKNASDIDSGKHRDVKMEITYARQAVQRAEDARVDTLRKKAAERQRNAEIAKNDAQQQAAQSQAQAEAARLAEQKSALDAQKSQLAAQQAQLAQANADALAAQARNKELEANQRADAANKRAESAEQMRERLRAQLNEVLQTTETSRGVIVNLSDALFDTGKYTLKTNTQVSLARVAGILQSYPGLKVQVEGYTDIVGSDALNQRLSENRANTTRDFMVKQGVPTDSISAAGYGKADPVADNGTAAGRAQNRRVELVVSGDAIGVKQSAPTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X094</accession>
    <name>E8X094_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="8" type="ordered locus">AciX9_3055</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581389.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3055"/>
    <dbReference type="EnsemblBacteria" id="ADW70075">
        <property type="protein sequence ID" value="ADW70075"/>
        <property type="gene ID" value="AciX9_3055"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3055"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_0"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="170" mass="18654" checksum="2BF7C3EAC22009BC" modified="2011-04-05" version="1">MNNTTTIPSGKDIQRKWFVIDAAGKTLGRLSTTAASILAGKLNPLYTPYIDMGDHVIVINAEKIVLTGLKADSKMYRRYTGFPGGLREESFIKLLARRPEAIVEQSIKGMLPKSKMGRQMATKLKVYKGGQHPHFAQQPVPLEFHASNAKKTPGVPKPGQPTHHIPALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X099</accession>
    <name>E8X099_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3060</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3060"/>
    <dbReference type="EnsemblBacteria" id="ADW70080">
        <property type="protein sequence ID" value="ADW70080"/>
        <property type="gene ID" value="AciX9_3060"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3060"/>
    <dbReference type="HOGENOM" id="CLU_1330378_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="23949" checksum="D1DBD4D462E2FBAC" modified="2011-04-05" version="1">MACLRLIRPMREYLGLFKGHLRDDGTIDIQSFSSPYSVEEVSEVEKLFTVRTVDALRLREIAPYFIEARRNKRWKILMAVEFYQAGFFQTNYWKARYALRCSSIEAVFGSTKHRKARVTKDRILKFLGGDTRIYEPGDIPDYLQQATDITVGSVLEELFDVRNCIAHGDRIPDRFFAGIQDREFSASFPLWQCSTRRQVQSRGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A2</accession>
    <name>E8X0A2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisD</name>
        <name evidence="11" type="ordered locus">AciX9_3063</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581397.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3063"/>
    <dbReference type="EnsemblBacteria" id="ADW70083">
        <property type="protein sequence ID" value="ADW70083"/>
        <property type="gene ID" value="AciX9_3063"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3063"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_0"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="44822" checksum="20703BDD85C26F10" modified="2011-04-05" version="1">MKLVKTYGESAKAAAALIESIEQRGATNTARVENTVSTILADVRQGGDEAVMEYAARFDGLQCINGKSQPLLVTREEMKAAWDDTDATLREAMEIAQANIRAFAEAQKPGEWTIEPAAGVQTGQIVRPLGSVGCYVPGGRYPLPSTLIMTVTPAQVAGVARIVVCSPKPAKETLAAGWLCGVTEFYRMGGAQAVAAMAFGTQTIGRVEKIVGPGNLYVTAAKAAVSHECGIDMPAGPTEIGVMSEHGDPAGIAADLVAQAEHDPETLAVLITPSETLAEAVLAEVKQQAKANEIAEQSLTAQGAIFVTKTVTEAQDLTNRLAFEHLTVDNTTDLKWVQNAGSVFVGQYSPQSMGDYVSGPNHVLPTGRAGRIRGGLSVMDFLKIITVQEYTRSGLAHLGPHAIAMAEAEGLVGHAESVRVKMGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D2</accession>
    <name>E8X0D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0726</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0726"/>
    <dbReference type="EnsemblBacteria" id="ADW67796">
        <property type="protein sequence ID" value="ADW67796"/>
        <property type="gene ID" value="AciX9_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0726"/>
    <dbReference type="eggNOG" id="COG3657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152445_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014056">
        <property type="entry name" value="Addiction_killer_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41791">
        <property type="entry name" value="PTHR41791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028744">
        <property type="entry name" value="Addict_mod_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02683">
        <property type="entry name" value="upstrm_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="13501" checksum="1995E95D199D1CB5" modified="2011-04-05" version="1">MYEIEHYLTPEGRDLYQDWHRALRDSKAKQAVDRRIYRMEAGNFGDHKFCRDGVWELRVDVGPGYRVYYAMDGLQIVLLLCAGDKSSQSKDIDRACGYWRTERETRNHADNQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E3</accession>
    <name>E8X0E3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0737</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579133.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0737"/>
    <dbReference type="EnsemblBacteria" id="ADW67807">
        <property type="protein sequence ID" value="ADW67807"/>
        <property type="gene ID" value="AciX9_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0737"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_0_0"/>
    <dbReference type="OMA" id="IWQKERG"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8363" checksum="E43E4BF6584E2B6B" modified="2011-04-05" version="1">MAQYKGEVKWFNNAKGFGFLGREEGPDVFVHYSSIQLDGYKSLKEGDKVEFDVIQGEKGPQADRVTRTVHATLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M9</accession>
    <name>E8X0M9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1934</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580299.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1934"/>
    <dbReference type="EnsemblBacteria" id="ADW68980">
        <property type="protein sequence ID" value="ADW68980"/>
        <property type="gene ID" value="AciX9_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1934"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_2_0_0"/>
    <dbReference type="OMA" id="FGNADKY"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1001" mass="106216" checksum="DBF240B6725840A8" modified="2011-04-05" version="1">MMAAPAAWAADVRGLVTFGGLPIPGATVTVAQGTKKFVTVTDTQGFYSVTGPADGAATVTVEMTGFTPVTLEVTVAADAALGKAELKLMTLQQMQSELKPVAAAPFTETQARTEVKKTGNAPQVARAAGENAPPPPAETVDKAADGLLVNGSVNNAATSRFSLAPRFGNTASGRSLYSFSLNARVGNSVLDARSYSIAGFDTPKPQTSELTGGFSFQGPIKIPGVLRNGPNLYVGYQREQNSDSVSTPGLVPDAFERVGDLSHELNSAGQPLVVYNPATGLPYPNAQVPITPQAQALLNLYPLPNISGNSQYNYQVPLVTDTHQDSVNSNVSKTIGRKDQVTGTLAAQSTRTSYQNLFGFTDQTHRLGLNSTVSWAHTYSSRLRTNLSYQFSRQSNRLTPFWQNRTNVSGAAGINGNDQDAAYWGPPTLNFSGGLSSLTDGQSSFLRNGTNGLSFTGKMNRYNHNFTAGGDFRRQQFNYLTQANPRGTFTFSGAATAGTATGSGSDVADFLAGVPDTSAIAFGNADKYLRQTVYDAFFTDDWRVSPVLTVNAGVRYEYGAPVTERKDRLVNLDVASSNASSFAAIAPVLAGSPKGTLTGTSYPNSLTRPVRTGIEPRIGISWRPIAGSSMVVSAGYGITYDTSVYQGIALDMAQQAPLSKSLTLQNSTACPLTLANGFNNCATTTPQTFGVDPNFRVGYLQTWNLRVQRDLPHSLQMTAIYLGNKGTRGAQLFLPNTNPAGAVAVCPLCPVGFEYLRSGGNSTRESGQIQLRRRLKSGFLASLLYTYSKSIDDDSALGGQGAATLSSATIAQDWRNLNAERGLSTFDQRHLLNATIQYTTGMGKGGGTLLTGWRGKLYKEWTVQTQITAGSGLPETPLASAVTVAGYSAFVRPDVTGAPLYGGTGGRFLNAAAFATAAPGQWGNARRDSLTGPGQFTLDTALVRTFRLPEKLTLDLQIAAANALNHVSYSNYVSNVNSTLFGLPGAANSMRSLQTSMRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V0</accession>
    <name>E8X0V0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3118</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3118"/>
    <dbReference type="EnsemblBacteria" id="ADW70134">
        <property type="protein sequence ID" value="ADW70134"/>
        <property type="gene ID" value="AciX9_3118"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3118"/>
    <dbReference type="HOGENOM" id="CLU_2464707_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9803" checksum="1411B40502BD7B01" modified="2011-04-05" version="1">MHGRKIRYISVDVVRQRTSKRDVEIPRLSSTYRSVELALENLDSLLDDGIMPEVSAIGTVKDGYGVQAVQNLANPLLETDAKLMTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X0</accession>
    <name>E8X0X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581467.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3142"/>
    <dbReference type="EnsemblBacteria" id="ADW70154">
        <property type="protein sequence ID" value="ADW70154"/>
        <property type="gene ID" value="AciX9_3142"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3142"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_2_0_0"/>
    <dbReference type="OrthoDB" id="1478083at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="30984" checksum="C8A82EFAE42EF9CD" modified="2011-04-05" version="1">MSNRTRVMWNGTVRALPFKEQVEAAAIAGCSAIAVTPSDYNKWVGASLSTRDLLKIASDGGVKITHLDPFVRWTADWKPHLEGMDFPIDIVGFDEDDFFRMAEALEVDSFTAWSGFSANRYSLPEIEDAFGSVCVRAAKSGLRCDLEFIPVFGVSSLKMAWDILQQVKADNAGIVFDFWHYMRSGPNEELLRSIPGDKITAVQLCDATAEVPKGMSLAYDGLNHRLTPGDGDFPIAALVETLYQIGGLNNVGVEVFSPKYDKLSAEQVGEITRTVFEQFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X103</accession>
    <name>E8X103_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0801</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0801"/>
    <dbReference type="EnsemblBacteria" id="ADW67869">
        <property type="protein sequence ID" value="ADW67869"/>
        <property type="gene ID" value="AciX9_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0801"/>
    <dbReference type="HOGENOM" id="CLU_159325_2_1_0"/>
    <dbReference type="OMA" id="NEMVQIV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9840" checksum="C70D82957BD3CD9E" modified="2011-04-05" version="1">MPTVWERRDCVSAQVEDSLVILDLETLVYHSLNSTASALWELLAEPKPEAALVEALCEQYEVSPEHCSVSVRGLLAQLEASKLVSEKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X105</accession>
    <name>E8X105_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0803</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579196.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0803"/>
    <dbReference type="EnsemblBacteria" id="ADW67871">
        <property type="protein sequence ID" value="ADW67871"/>
        <property type="gene ID" value="AciX9_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0803"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663525_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012668">
        <property type="entry name" value="CHP02466"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13759">
        <property type="entry name" value="2OG-FeII_Oxy_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="414" mass="46135" checksum="7BC3BB8A217584F6" modified="2011-04-05" version="1">MSTQPSIAAPGIEPETRLSLEIPMLKMLTSKEELSLALTAYTRAPESHELRHRLAAQLLAADRFDEVIALLEERKDLSSRTLNLLSSALLARETHLDDERALVIAEHAVQLSQDQKERALTVTELAKVVTRLGDLQRAEELLQQALNLQPSEKDAYKRLFQLKLQRSREEALVFAQDTIAAGVCHSRVLGSAPLALALLGRIDEARAAEGSHQFAASFDPEPPPGWDSLKQFNDALTAEALNHPDARFNRYGVASAQTWRLDEPALQRTKCFQQLQKLIQRETERYARTLPDTGHPWLQAMPQSAVLRNWTVIVEGDGYETWHVHQNGWMSGVYYIHVQDHIAQGSGNGGCIAFGLPDAVVGADAAAAFGETLVRPHSGLMMLFPSHIFHRTYPHHGSGRRICYAFDIIPSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X122</accession>
    <name>E8X122_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0820</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579213.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0820"/>
    <dbReference type="EnsemblBacteria" id="ADW67888">
        <property type="protein sequence ID" value="ADW67888"/>
        <property type="gene ID" value="AciX9_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0820"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_0_0"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="34686" checksum="D37C6D53E5B3C792" modified="2011-04-05" version="1">MATPLSHWIGFHLALVVLLAGELLFSRVGMARLGETEKLRRQHRNAVVATVMWVAAAFVFAAFVWKTMDGANATQFLAGYALEESLSIDNLFVFLLLFKVFRIEATHQPRVLFWGVLGAIVMRGAFIAAGIGLLTRFHWISYVFAVLLLVASVRLVMPEKEEDADKPPAWIGWVSRLHPVSMTQKSFFVRENGRRMMTMLFLALIAIEFSDVVFALDSIPAVLSITRHPFIAYTSNILAVMGLRSLFFLLAKALKQLRYLHYGLAAVLAFAAVKMLAAEWYEVGPLVSLGVIVGILALTIAVSLIHKKPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X173</accession>
    <name>E8X173_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0871</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579264.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0871"/>
    <dbReference type="EnsemblBacteria" id="ADW67939">
        <property type="protein sequence ID" value="ADW67939"/>
        <property type="gene ID" value="AciX9_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0871"/>
    <dbReference type="eggNOG" id="COG4640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1328" mass="138622" checksum="47AFC6C76394A86E" modified="2011-04-05" version="1">MRDRIKNLFLNCVAVSVTTPRMGVRSRFSGFAGVGLGLTLLAGSSMIAAAQTGGEAGIQGTVTDSTGAAIPGATVVVTNTATGVTTTRQTTGDGLYTISPVIPGIYTVAVTSPGFSKHVQSNLTVDALKFTALNVAMEIGAADQSVNVTTEPPLLETTNATLGLTIENSTYSALPLQMNGAQRDPTAFGSLAPGAQGGARLPIIGGTGNYLGQLYLDGLPAETINQQADNRVVSQAVSVDAIDQTQIITSTPPAEYSGAGASNFTMKSGGLGYHGQVSDFIRNTSLDAWGFSVKAQTIKNAAGVTVPAPKPIDHQNELSASFGGHVPGTNRIFFFVAYDKYHNRSVKNPASYTIPSALEKMGDFTELNGGVGTGGLSGTGANNPAFLFDPTSTNCVGNVCTRQPFQGIKNGVPTNNVIPTSYISPISKAAESFLPDPNNAATLVNNYTSGLNTGFDNHSLDYRVDFDVSPKHRISTIGAMGTVQYLNNYGAPYLPQPYTGGDLAAIFPKVYDVEDSYQIRPSISNQLKFGFVRFFMNIQNSTQGVTQYQANTLGITNLPVGQAATEFPGISFASTPFFGTAQQTYTGNSNATSTQITTPNNFTLVDNISITRGRHAITAGIQVQWQEINNANPATFTGVLSLPFTGYSTANFAANSNALTLGTATAGSGYSYASFLLGAVGNAGTVAPSIGLQPVSELGGRYRPIAPYIEDTWKVNSKLTVDAGLRWDYLPPFHEVKDRWSFLNPTLTNPGSGTPGAIQFAGNLGGAGASCGCRTPVKTYWKNWGPRVGITFSPDDKTVFRIGAGRVYSQGGGVGGRVGAANGTGQLGLNVTATGPSEITTGANAGPSFYLNNSSAFQALGKANTSLFGAGYQYPTAPTPGSATEALNAGNYVNGAGAFVTPQAVSYADPYFSGRAPNFMFYNAGVQRSLTNDMTLAINYVGNQSHHLYNSTVGGANIRGYWSNQLNPIYLAGLGGVSNSAGTAPLLTAAATPANVAKAQAAMPGISIPASYQAAAVSNSSATIAQALVAFPQYSGVTDTWGVNVGNFSYNSLQVTLQQRFHQGVTFNFNYTWSKNIGDDGTFRSGFDIPGAAISGGGKSYKQDRIERGNTTVSQPHVIHAYGVWELPFGKGKFGGNHLVARAIASGWQLSGIYTYAVGTPVAVTWTACAAGNYPLQGQCMPNVNPNFTKSSARINGGYGQGAGGRTACNLGVGTGCVATKYIDGTAFSAVPSVSGLAASPIYLLGNAPRTSAFNLSNPGAQNIDTSLRRTIALHDKMNLQVEVDCLNTWNHTIFSSPVATFGSTTFGTVTSTANSPRDFQLAGHFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B3</accession>
    <name>E8X1B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase, NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2022</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580385.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2022"/>
    <dbReference type="EnsemblBacteria" id="ADW69067">
        <property type="protein sequence ID" value="ADW69067"/>
        <property type="gene ID" value="AciX9_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2022"/>
    <dbReference type="HOGENOM" id="CLU_2508072_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9239" checksum="193A5928FD529DE3" modified="2011-04-05" version="1">MPKLEHASASSTRKIKPPTTTEFSEAARRGHKTLTGDVLKEIRTGKLAVRSSAVAPDPAIATLRKRVIALESEKTRLKVQMMNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C1</accession>
    <name>E8X1C1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2030"/>
    <dbReference type="EnsemblBacteria" id="ADW69075">
        <property type="protein sequence ID" value="ADW69075"/>
        <property type="gene ID" value="AciX9_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2030"/>
    <dbReference type="HOGENOM" id="CLU_1155144_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="25929" checksum="246CFF3545A52FEF" modified="2011-04-05" version="1">MLPLAFAFIVFLFLLVGAVAFVLSALVPRLRRFAFSSSLWIAVWGPCTVLLVTLAGVGIFTGAAITQGGHLQAVRAPQLLKAVGWSYLVCGVLGTLVVATATAWIHQALIQRVTFALFRIYATLVAGGIGSVFGWAFGWWIAAHSLSHGWALWLASMLVLIPAFGVAAYKSAGQLRETHPPISPGSPPKNLPDRDSRKPRLRPDLADLHIAPTRIPIYHEPCLTFESRNVQPSSNVVCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F4</accession>
    <name>E8X1F4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RepB_primase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581501.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3178"/>
    <dbReference type="EnsemblBacteria" id="ADW70189">
        <property type="protein sequence ID" value="ADW70189"/>
        <property type="gene ID" value="AciX9_3178"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3178"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885464_0_0_0"/>
    <dbReference type="OMA" id="SESDWAW"/>
    <dbReference type="OrthoDB" id="1115460at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039459">
        <property type="entry name" value="RepB-like_DNA_primase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16793">
        <property type="entry name" value="RepB_primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepB_primase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34795" checksum="5385D2CB14EAD381" modified="2011-04-05" version="1">MNEVAKDFLVRCFAPDSTIALLLRTESPAKTQQRVVTLEQALGPRYLSWLAHENHAGANVYVAANPLRCGSRRRTKESIDSVRHLYLDIDEDGDARLAALRASDSVPPATAVLSTSPHKHQALWRVDGFNFEQQEAALKQLAIAFGGDPACTDCNRVLRIPGFLNRKYSPAHCVTVEYGSEAILSSADFRLPDVPAVTSLSLRSTARSAASHKDTRSEQDWAWISAQIAQGKDAGKLTHELASRRPDKPNPLYYAQRTVDMASARQWFLKGAPLDDVITMLCDRRCFELPAALCSARTREIATTAQRMAARHNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G8</accession>
    <name>E8X1G8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3192</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581515.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3192"/>
    <dbReference type="EnsemblBacteria" id="ADW70203">
        <property type="protein sequence ID" value="ADW70203"/>
        <property type="gene ID" value="AciX9_3192"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3192"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_0"/>
    <dbReference type="OMA" id="IALHISC"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="35165" checksum="5350371CB0CC60A8" modified="2011-04-05" version="1">MSESVELRHLKYIVAVAETGNFTRAAQRLYVSQPALSKQIKDIEEEIGFQIFLRTPDGVFPTPVGQMIVDYAVATLYGHNYVFRMAKEIYLGNVPNLRVGFSSFVNARHLHTFRTSYARHFPKCVLQLSGGDTVNILQRVERGDLDCAILNLPVVGSHWQVVPLASSPIVVCMRTDDPLTEKSIVTVSDLSERLTVFRDPEGHPSAHARLTQMLTEAGIALHISCSAATPHDIQLLVRDGFGLALVSEDTLLESDITTRRIAGVSWTCDTAFVYQPAAVHPALSFVEKFIVGTGKRLLRKEVMSERPQLSLSFDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H3</accession>
    <name>E8X1H3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ordered locus">AciX9_3197</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581520.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3197"/>
    <dbReference type="EnsemblBacteria" id="ADW70208">
        <property type="protein sequence ID" value="ADW70208"/>
        <property type="gene ID" value="AciX9_3197"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3197"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_0_0"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="28993" checksum="909F27A6616B5B2F" modified="2011-04-05" version="1">MKRRKSQPEAPPTASSRDLETLLGHRFARPNLLTLALTHRSFVYDSGQTAPENDLADPARDNEQLEFVGDAALGLLAAESLCRRFPASREGELTRLRASIVSRKHLGEVGTRLDLGRWLRLGHTAEKNDGRRNAALFANAVEALIAALYLDGGLEVARRFVEDEIVSPAIPALEQSLGEGERFAGAVGDHKSALQEMLQAEGLGRPEYRLIAESGPDHKRLFSVEVLIEGPDSEAIAQAEGPTKKQAQQEAARLAVAALAGRKTAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I7</accession>
    <name>E8X1I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3211</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581534.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70222">
        <property type="protein sequence ID" value="ADW70222"/>
        <property type="gene ID" value="AciX9_3211"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3211"/>
    <dbReference type="HOGENOM" id="CLU_2879573_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="7064" checksum="A61B45477721E810" modified="2011-04-05" version="1">MAVEHKHIAIRSAELSGNGLIIHFSDGTTTLFQTHFLYEVREQNGNVALTDLSEDELMKGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I9</accession>
    <name>E8X1I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_3213</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581536.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3213"/>
    <dbReference type="EnsemblBacteria" id="ADW70224">
        <property type="protein sequence ID" value="ADW70224"/>
        <property type="gene ID" value="AciX9_3213"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3213"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_1_0"/>
    <dbReference type="OMA" id="TKQTLRW"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="8">
        <location>
            <begin position="169"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="602"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="668"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="874" mass="96613" checksum="010970600F747539" modified="2011-04-05" version="1">MIKSTREVDRQDDVSTTGQQDLSGNASVDETTVSTVACEDEPIRIPGSIQRHGFLLLLDEGAKLVVGASENVEEMLGVPWKLILGTPVETILEREVLAALRAPGLDEEQLGTVTYLGSFPVRHELYSVVTHRTGTRRALEFERIDRLVRPELMNVVITNFVGQLSKLKTEDELCRAITKQVLDLTGVNRVMLYSFNEAGHGTVMAEESDGTLPSYLGLRFPDGDIPQQARDLYLLNTVRIIPDSSYIPSPLHVLSSEAGTPVDLSMALLRSVSPIHLQYMQNMGTAASMSISIVCEGKLWGLISCHHASPRVVPYLVRSACDLLTKLVGTLLTGLRTTDRLVKMVHFHAVQRRILTQMAAENDYVAAMQAQMTSMVEVTDASGVALIVDGVCELAGDTPAMGDVLRLAEWMNREPEMELYSSRELGLAVEWAEAIQGVASGMLAIRISTVKQSYVIWFRPELVRAVSWAGEPLKIEQEERGLEPRTSFKAWKVLVRGQSEPWSDMEIESAREFRAAVMTISLKRAEEAAELSESRFKQLTHALPNLVWTTNDDGLLNYVNERWRDQGLGDEGRWFDQGRVFEEDRERCMELWAVAVREGTAFEAEVRLLCGTDRVERWNLVRAAPFVRANGMRAGWVGTCTDLTDRHERELALKLTEKLALTGRMTSVIAHEINNPLEAITNLLYLLRDEVDGDGPAKSYIAMAESELQRISGITKQTLRWSRDGTQKAEHGTAAMLFDDVLRLLAGKIRNREVTLTVSGGGTPLFGVISQLQQVLANLVSNAVDAVPVGGRVWISAKASGSGMEVEVGDTGLGMTEEMLRKIFQPFYSTKGDLGNGLGLYISQEIVERHGGQLTVVSEVGVGTRVRVGLPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M3</accession>
    <name>E8X1M3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0874</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579267.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0874"/>
    <dbReference type="EnsemblBacteria" id="ADW67942">
        <property type="protein sequence ID" value="ADW67942"/>
        <property type="gene ID" value="AciX9_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0874"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_0_0_0"/>
    <dbReference type="OMA" id="HEITIIQ"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="19587" checksum="682D40CF616C8A53" modified="2011-04-05" version="1">MIHLHEITIIQAPIHRCFDLARSVEVHLLANIHSGEQTVATSGVTSGLVALNQHVTWRARHFGLWQNLTSQTTALTAPTYVQVTMTRGIFHSMQADHHFRTLPSGATEMRDDFRIAAPLPILGLLAERLFLSRYMLALLRERNQVIKQVAESDSEDWRNYLPQPHQQYEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N8</accession>
    <name>E8X1N8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0889</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579281.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0889"/>
    <dbReference type="EnsemblBacteria" id="ADW67957">
        <property type="protein sequence ID" value="ADW67957"/>
        <property type="gene ID" value="AciX9_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0889"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_0_0"/>
    <dbReference type="OMA" id="DPEHQPY"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="44071" checksum="5FB2F94B17CD7CFD" modified="2011-04-05" version="1">MESFFSRFKNPLALIVILLVQAVALGVQIHRPTDQASPDGSQVRLLRLWALSIMSPFERVSTGTGHGVRGAWSNYLDLRHVRQNNQDLRQEIANLRLQRAALAEDALEGQRLQSLLGFQQHYVSKTVAAQVIGTSGTDQSRVLTLDKGAQDGLKPDMAVITPDGIVGKLRDVFPHTSQLLLVSDPTSGAGVILQATRIRAILHGSPQGRIQINNLTIDSRIKPGEVVLTSGGDQVFPRGLPVGKVESMVPDPEHQPYALITLKPAANLNQLEEVLVITGISPTLGAQTQEELAAEAAARAADTSAERLPGLKADKPEADPTKPVDPNAPAENAPPPSDNAPGLVPKPKPVVHADRFTYGSPAAAADLTPGAPKSDAVPVPHETAPKADVPAKPKAAPKSDAAKPEAPKPEQEIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y4</accession>
    <name>E8X1Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2101</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580461.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2101"/>
    <dbReference type="EnsemblBacteria" id="ADW69145">
        <property type="protein sequence ID" value="ADW69145"/>
        <property type="gene ID" value="AciX9_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2101"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_0"/>
    <dbReference type="OMA" id="HWLLLTY"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="44898" checksum="76260C2A6FE6DA75" modified="2011-04-05" version="1">MGIAANWTALNRAQKNTFAACFLGWTLDAFDFFLLTVCLPSIATEFHVDLATMANALFWTLVMRPVGAALFGAMAERYGRRPTLMLNIVAFSVFELGSAFAPGIGSFMVLRALFGVAMGGEWGVGAALAFETLPAKGRGFFSGLLQEGYVVGNLLAGLLQWLLLPHLHGTGHFTPWRVLFMIGALPSLLAFYLQFHVEESPVWLEAKRTGRTLKNSFEASKLKEYLPSFLFLVLMMAAFTAFSHGTQDLYPSFLKRDKGLFDAAAGKVLVVANLGALFGGICCGTISERLGRRKTIMFASLLALPMIPLWAFSHTVVMLAVGGFLMQFMVQGAWGVVPAYLNELSPAPVRAVFPGFAYQLGNLLMSKNGNVQATLAKRFPGGLRTVLAGTVVVVALVLTVVTSFGKEKVGAELGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X233</accession>
    <name>E8X233_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581588.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3265"/>
    <dbReference type="EnsemblBacteria" id="ADW70276">
        <property type="protein sequence ID" value="ADW70276"/>
        <property type="gene ID" value="AciX9_3265"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3265"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_1_1_0"/>
    <dbReference type="OMA" id="GEWRYRI"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10255" checksum="56209C54E61A14AB" modified="2011-04-05" version="1">MAWLIELDEDAERDLARLDKSVQRTIIKYLRTRIAPAADVRDFGKPLGHALSGLWSYRVGDYRILCNIEQDRLTVLVVGIGHRKDVYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F7</accession>
    <name>E8X2F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2137</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580497.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2137"/>
    <dbReference type="EnsemblBacteria" id="ADW69181">
        <property type="protein sequence ID" value="ADW69181"/>
        <property type="gene ID" value="AciX9_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2137"/>
    <dbReference type="eggNOG" id="COG4947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090325_0_0_0"/>
    <dbReference type="OMA" id="NREYHRW"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="27359" checksum="7832757AAEBB35CD" modified="2011-04-05" version="1">MHREYHKWHSPSLGRDMELTVYGHAGLPAIVFPTSQGRFYEFEDRGMVAAIEHKINNGEVQLYCVDSVDAESWYNKSVGPDWRIARHVQYDNYIVHEVVPFLRNKNWNRQIASIGCSFGGFHAVNVAMKHPDIFTAFLSMSGAFDLSGFLGGYHDQNVYFNQPLQYLANMSDAWFLDRYRGSSYVLATGVHDQCWDFNVKLAHVMRSRGIPVRLDVWGDDTGHDWPYWHKMIQTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X310</accession>
    <name>E8X310_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1081"/>
    <dbReference type="EnsemblBacteria" id="ADW68144">
        <property type="protein sequence ID" value="ADW68144"/>
        <property type="gene ID" value="AciX9_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1081"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_2_0"/>
    <dbReference type="OMA" id="CGIATNI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="26099" checksum="A0B3CB323D7D2091" modified="2011-04-05" version="1">MGTRVRRAVILAKPEPQYWYLQLQLQLQLQLQLQLQLLVELYTPWTQRTAMPLTQLDPHAALIVIDLQKGIVAYPLAHPAEDIISRSAALAQAFRTRNLPVVLVNVTAAARGRTDMGPRNLAFPEGWDQLIPELNQQPTDILITKQRIGAFIGTNLHAELQQRGITQLFLTGIATGSGVEATARSAHDHGYHVVLITDAMTDRTLETHTYSAEKLFPKLGETTTTEEVLKRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X323</accession>
    <name>E8X323_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1094</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68157">
        <property type="protein sequence ID" value="ADW68157"/>
        <property type="gene ID" value="AciX9_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1094"/>
    <dbReference type="HOGENOM" id="CLU_2825085_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7430" checksum="DAF8339DB5916E02" modified="2011-04-05" version="1">MRTALRRCRSLRCAGDDKQKQEQRQPQIPYGNDKQRGNSTDGGYGKDNDNDNDSDNGNGNGEIPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X395</accession>
    <name>E8X395_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3390"/>
    <dbReference type="EnsemblBacteria" id="ADW70396">
        <property type="protein sequence ID" value="ADW70396"/>
        <property type="gene ID" value="AciX9_3390"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3390"/>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140900_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="15873" checksum="42D64C2B6D1EACDA" modified="2011-04-05" version="1">MKTLSKPANTSRNPSIGKTKRPSSGSSPSAKPRRLNKPSTSNLVQRSGGEPLTQHDLELLEKLLQDKERVINFTDSPEVTTNTFANRSGILGLFKPYKQQITLRIDGDVLAWAKRDGAGYQSRINAALRKAMLEDVRLTRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X396</accession>
    <name>E8X396_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581709.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3391"/>
    <dbReference type="EnsemblBacteria" id="ADW70397">
        <property type="protein sequence ID" value="ADW70397"/>
        <property type="gene ID" value="AciX9_3391"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3391"/>
    <dbReference type="eggNOG" id="COG2307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071567_1_0_0"/>
    <dbReference type="OMA" id="FWIGRYV"/>
    <dbReference type="OrthoDB" id="1433145at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="332" mass="38073" checksum="D9DF2BE358574711" modified="2011-04-05" version="1">MLSRVADSLYWMSRYLERAEHTTRLLDVNLNLMLDESATSADRRWQRVLLALGNPKDVVWAGDPYALTQTLTFDGTNPASIRSLLIAARENSRHVREQISTEQWDRLNRLYLEVTRPQTQRRVEPGTMALEPEQPTEFLQHVMEAVHQFQGVTDSTMSHGEGWQFIQVGRYIERASATASLLQAYHAELWGDPESDAERQTEGNEYLEWMGLLRSATAFEAYCKVYTADLTPERILEFLLLDEEFPHSLRFSIDSLQCALEAIQHEGGKSRADKLRRLSGRLQATLNYSGVEEILEQDIVAYLQAIQAQCREIHLVIYELYVDYSIQSALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F8</accession>
    <name>E8X3F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M56, BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70459">
        <property type="protein sequence ID" value="ADW70459"/>
        <property type="gene ID" value="AciX9_3454"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3454"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="LTWHHET"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26781" checksum="4538E22EC3C69277" modified="2011-04-05" version="1">MDGRTRRVALAAAFVVLGSRYGLGQVAPAVGFEVVSLRQSPPGTMSNLTPPEGSRVHEAGISLTILIQLAFGVERDQVRGPEWLDSQMYDLNATTQGGVSLTRQQMMPLLQQMLTERLKLTWHHETKDVPGYGLLVAKGGAKLEASTGATEGSGNYILSNEIRLQSASMLSFAAALRIPLHQPVIDKTGLTGEFHINLSYAPEGSEDSTLPSIFKAIEEQLGLKLQAQRVPVEVVVVDHVERQPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X409</accession>
    <name>E8X409_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Virulence factor MVIN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3512</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581828.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3512"/>
    <dbReference type="EnsemblBacteria" id="ADW70517">
        <property type="protein sequence ID" value="ADW70517"/>
        <property type="gene ID" value="AciX9_3512"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3512"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_2_0"/>
    <dbReference type="OMA" id="KIFWPSA"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="531" mass="56656" checksum="304EB808BB31E7D8" modified="2011-04-05" version="1">MSTTQPTTQPIPETTPRAGFFSLKHQHSVFSATMLLMGASLLSGVLGLVRTKYIAYVFGAGSITDAYNAAFNLPDMISYFLIGGVASITLVNILSRYREAGDEEGADRALSIILNAMMVVLGTGILIAELIAPWYTAALFPKLNPETAALCTHLTRLLLPAQFFFFVGGVLGSRLLVRKIFLYQAITPLIYNLGIILGGVLLSARLGIDSLAYGVLGGAFVGAALLNAIGAFRGGLRYTPIFNLKHPAFLEWLKLSLPLMIGVSLAMADKWILGYFATADDGGLTRLQNAKTLFNAPLGIIGAAAGAASLPFFTSLYAQGRHFDFNAAVNRAVSRLLAVGLLCTAWMCSLSVPILDIYRGGVYSKADALNTAHYFAIFSVSLALWSAQGIYARAFYAARNTLTPAISGTVVTLVSIPIYALLFHHIGVDGLAIASDLGILAHTVALAVLLHQKHIVSLASLEFEEIGRALIAALLAYFLTSTAIPYIPHPSGHPGDIVVILIASALWAGVILFTLQLSGSKLIQQLRNRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X471</accession>
    <name>E8X471_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0040</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578460.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67131">
        <property type="protein sequence ID" value="ADW67131"/>
        <property type="gene ID" value="AciX9_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0040"/>
    <dbReference type="HOGENOM" id="CLU_2617039_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8540" checksum="72F807530903F087" modified="2011-04-05" version="1">MMLTTIRIRVLHGIEELILDQPGVTSIPALGDSVSCFGTRAIVTGSTIVHTPEGHRSILLHAEMQSRILNAWSRLYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C3</accession>
    <name>E8X4C3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1187</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579573.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1187"/>
    <dbReference type="EnsemblBacteria" id="ADW68250">
        <property type="protein sequence ID" value="ADW68250"/>
        <property type="gene ID" value="AciX9_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1187"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_8_0"/>
    <dbReference type="OMA" id="IAIQFVH"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="550" mass="59679" checksum="B42C43FF82BB0D70" modified="2011-04-05" version="1">MAKPVLLAIDDDVSVLEAVVQDLRRKYGQTYRIVRAASGGAALDISKQLKERGDVVALFLSDQRMPGMTGVDLLQAVIELYPDAKRVLLTAYADTEAAIRAINSARIHYYLNKPWDPPEEKLYPVLDDLLQAWNQGHKPAYDGIQLVSARWGVGDHEVRNFLSRNRIQFKWLNPDLNPEAMSTLRDRGLDEGKLPVVLFGDGSSLVQPTTTEIAQKVGLRTQAQQEYYDVVVVGAGPAGLAAGVYGASEGLKTLLVEPMAPGGQAGSSSKIENYLGFPEGVSGDELAKRAYIQAQRLGAEFLTQGVTNICSDNGYHILRMTDGREVTCRVCLIATGVDYCWLCVPGEERLRGKGVFYGAALTETNTCANEEVHIVGGANSAGQAAMHFSKHATKVRMLVRGPSLTQSMSKYLIDQIAATPNIVVETGTEVIGVEGDGNLERVKLMTPEGEVTRDCVSLFIFIGAAPKTDWLPKAVALDNKGFILAGPDLKTKSKEDSVWKLERDPYLLETSLPGVFVAGDVRHGSVKRCASAVGEGSIAIQFVHQYLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L0</accession>
    <name>E8X4L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2383</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580736.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2383"/>
    <dbReference type="EnsemblBacteria" id="ADW69420">
        <property type="protein sequence ID" value="ADW69420"/>
        <property type="gene ID" value="AciX9_2383"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2383"/>
    <dbReference type="eggNOG" id="ENOG5033CNG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076362_0_0_0"/>
    <dbReference type="OMA" id="WGLIARI"/>
    <dbReference type="OrthoDB" id="1421843at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234165" evidence="2">
        <location>
            <begin position="39"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="35773" checksum="D53E6E8754A25BFD" modified="2011-04-05" version="1">MRSRVRSTKRKTILGNAAPSVRALTTLLLLSLAPLAHSQHPAQPHTQPDQWKSSVGDPLARNPRDWAADAAANEKEAIQFNGVYVRYRIHMVGARGDQIRDVLESKDGTVARLIFKENRPLTSEEDAAEHQRLQDMLDSPSAFAKHVKGDQSGKKLATDLVALMPDAMLFTYTPGQPQRGNKENKGEPADIVMDFKPNPAWNPPTMTSEALTGLQGRVWIDRRTRHMVRLEGDIFRPVNLGFGMVARIAPGGKVTLEQVGLTDQRWIFSHFVEHVTVRALMVKTFKENSEIDGFDFTQVKPMTYQEAIKALLDTPLPHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M1</accession>
    <name>E8X4M1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69431">
        <property type="protein sequence ID" value="ADW69431"/>
        <property type="gene ID" value="AciX9_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2394"/>
    <dbReference type="eggNOG" id="ENOG5032Y4J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201154_0_0_0"/>
    <dbReference type="OMA" id="FTHQKKD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8464" checksum="F91FBBA3B71DA0D7" modified="2011-04-05" version="1">MSIQFDMKPLTAVGLLLILLALIGYATGGLTFTHRHKDIDQGPIQISHDTRSTVPLSPYLSTIALVAGVGMVVFASRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V6</accession>
    <name>E8X4V6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosidase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3592</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581906.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3592"/>
    <dbReference type="EnsemblBacteria" id="ADW70595">
        <property type="protein sequence ID" value="ADW70595"/>
        <property type="gene ID" value="AciX9_3592"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3592"/>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_3_0_0"/>
    <dbReference type="OMA" id="KYYMIWG"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233680" evidence="5">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="39003" checksum="9D961C9D3290B8FC" modified="2011-04-05" version="1">MKQSLLLAVLLSALPVAAQSWQIGPFTRPIGNPVLSPIPASTFTDPILKTPTHWEALHTFNPAAIVRAGKVYVLYRAEDDSGSMSIGGHTSRLGLAVSDDGLHFTRRPDPVFYPAPDSQQSRESPGGVEDPRLVEAEDGTYVLTYTQWNRITYSVGIATSPDLVHWTKHGPAFLEAAGGKYAHLQYKSAGILTKVGDGRPIATRINGKYWMYWGEGTIHLATSTDLIHWTPVEDASGKPIAILHPHPGHFDSSFPEVGPPPVLTQAGIIVLYNGKNAPTGGDPTMGPNAYAAGEALFDPQAPGHLLKQTEHPVLQPTEPWEKTGQYAAGTTFAEGLVLFKGHWLLYYGCADSFVAVATAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y9</accession>
    <name>E8X4Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0092</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0092"/>
    <dbReference type="EnsemblBacteria" id="ADW67181">
        <property type="protein sequence ID" value="ADW67181"/>
        <property type="gene ID" value="AciX9_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0092"/>
    <dbReference type="eggNOG" id="ENOG503382W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771085_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="40178" checksum="E12F72DEBBAF5E93" modified="2011-04-05" version="1">MNSGHFATYLNLAFGAAAVFTLLPVIYYLCTGWAVRREKLFCYMRDDQALSIYYDQFPWSNTREADLAKRFRHQVSYLYGRRHFIAPLSLFTILSLGAFWGLCRSAQFNAHVLKGEFVISKTAAAALLGAFLWCISDELARIVRRDLSPKDVYGWGFRILLSVPFGFAAAAVLTADVGVPVAFFLGAFPTQTLFTFARRIAVQKLAMGDQQSDSGLELQQLQSVSRGVAETFQDNGIETISALAWADPVDLTIRTNLDFNYVLDCMSQALLWVYFEDKTRILFRFSLRGSQEVLSLTNDLNGVLVPFDSTQVLTPKQSQAKATLSNIAGILNLTEAALLTTLLQSACDPYTTFINRVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X572</accession>
    <name>E8X572_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1274</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1274"/>
    <dbReference type="EnsemblBacteria" id="ADW68336">
        <property type="protein sequence ID" value="ADW68336"/>
        <property type="gene ID" value="AciX9_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1274"/>
    <dbReference type="HOGENOM" id="CLU_131989_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025562">
        <property type="entry name" value="Tae4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14113">
        <property type="entry name" value="Tae4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19278" checksum="C6D19CD3AAF22749" modified="2011-04-05" version="1">MANPAPHVYKTLPSFSQMLSNYPHEGGPEVPKTLIGGDVNAAWITDTCAIRMSRALNYSGFPIPAQGHSKMYVVKGGDGMWYAIRVAELKAWLQAKLGPPSVAPVRGQKISMDAYKGRKGILALKIHYAPRPGENTAAAGHIDLWDGTQFAGEYSQQGQEQDDFDVAEDAVLWFATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A3</accession>
    <name>E8X5A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579690.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1305"/>
    <dbReference type="EnsemblBacteria" id="ADW68367">
        <property type="protein sequence ID" value="ADW68367"/>
        <property type="gene ID" value="AciX9_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1305"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057859_0_0_0"/>
    <dbReference type="OMA" id="FQVMGFN"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024408">
        <property type="entry name" value="Muramidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11860">
        <property type="entry name" value="Muramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Muramidase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="27150" checksum="5F52194E605572F5" modified="2011-04-05" version="1">MPDFVGKSLALSADGLADVAQKLGVGSAEIQTVVSVETHGAGFLQDRRPQILFERHFFSRLTQGAYDASHPGISSPTPGGYGMGGANQYVRLAEAVALNRHAALMSASWGIGQVMGANFAVAGFPDVETMVADMCDSEDAQLAAVGGFILGNKLNRFLAVHDWQSFARGYNGANYVINHYDVQLNGFYQKINAGASPDLHVRSAQVYLTFNNLDPHGIDGSMGPGTRSALIEFQTAQNLSQSGEADDPTMAALLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B2</accession>
    <name>E8X5B2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579699.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1314"/>
    <dbReference type="EnsemblBacteria" id="ADW68376">
        <property type="protein sequence ID" value="ADW68376"/>
        <property type="gene ID" value="AciX9_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1314"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_0"/>
    <dbReference type="OMA" id="THIATRE"/>
    <dbReference type="OrthoDB" id="1225778at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="34703" checksum="1D4A206F08ADE058" modified="2011-04-05" version="1">MQAIQITQTGGPEVLTLTQLPDPTPTPGQVSVRIEASGVNFIDTYFREGRYPAQLPYTLGQEAAGTIVALGEGVTGFHVGERVAFNAATGTYAEFALAPTSALLKLPDNISAQQAAAALVQGMTAHYLLHSTFVPQYNDKILIHAGAGGTGLLLIQMAKRFGAHVITTVSTEEKAALAREAGADDVILYTQEDVVERVHQITEGTRLPVVYDSVGKSTFEQSLKCLCPRGTLVLFGGASGAVPPFDLIRLSQMGSLYVTRPTLKDYVATREDLEQRARDVFRWVAEGSLKLRIAHTYPLAEAAQAHRDLESRKTTGKLLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E6</accession>
    <name>E8X5E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2458</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580809.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2458"/>
    <dbReference type="EnsemblBacteria" id="ADW69493">
        <property type="protein sequence ID" value="ADW69493"/>
        <property type="gene ID" value="AciX9_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2458"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016564_1_0_0"/>
    <dbReference type="OMA" id="VQFPFPD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="410"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="625" mass="68144" checksum="F1E0921F6028E83C" modified="2011-04-05" version="1">MSAAATAVMPDRALDAGEVLLIALEDVAALLRGRSQGLDRLIKAFDLSPFETSVVLLGAALELKPEVAKICAALHDDARMRYPSLRLALQHLPEAQWEAVAPGATLRHWKLIEVAAQDALLAAPFTLEEPVLHYLLGTPTLDGRIAPYLEPMPLPASLPASFGVAARDMIQALQAEKPVLLRGSGHTCKAEVAAAASAHNGMRVFRLQLPASLQSAELLDPLIRLLSREAMLHRFVLLLDQDTHPLGEAALQTLVRRYALPLVLASATQAPEGIAWKEISIDLPDAEERAALWVHALGDEISLLLGGEVQRIAGRFPFEPARIAAIAKKVREGSTDEPEAASLMTKLLWRLCREDTRLPGDGLIRQMATSATWADIVLPEASMAALRDIAAQARHQQSVMKVWGLGTRGAGIAVLFHGQSGTGKTLAAEVLAHELHLDLWVIDLSQVVSKYIGETEKNLSSVFDAAEQAGALLLFDEADALFGKRSEIRDSHDRYANIEVGYLLQRMEQYSGLAVLTTNLRGSLDTAFLRRLRFVVPFPFPDQTQRRRIWEGAFPPAVPCADLDYDKLARLNMAGGNIRNIALSAAYLAAEAQLPLGMEHLRLAAQRECAKFDRGMTEAELGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J5</accession>
    <name>E8X5J5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3619</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581933.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3619"/>
    <dbReference type="EnsemblBacteria" id="ADW70622">
        <property type="protein sequence ID" value="ADW70622"/>
        <property type="gene ID" value="AciX9_3619"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3619"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_0"/>
    <dbReference type="OMA" id="MAMSVGQ"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="15162" checksum="A0F860F1FD2D0C8B" modified="2011-04-05" version="1">MGMGGGGTGGAVSEINVTPLIDVLLVLLIIFMVIVPVTPKGLDAIVPQPPKNQQQNEPDSKTIVVSILDNKGGEPSYKINEDSIAKSELEARLQGIFAVRQTKVMFVKGDPDLFYGKIAEVIDFGHGAGVDNIGIITPQVAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y6</accession>
    <name>E8X5Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4090</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70870">
        <property type="protein sequence ID" value="ADW70870"/>
        <property type="gene ID" value="AciX9_4090"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4090"/>
    <dbReference type="HOGENOM" id="CLU_281160_0_0_0"/>
    <dbReference type="OMA" id="KAIEHHT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234429" evidence="3">
        <location>
            <begin position="42"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_MalT" evidence="5">
        <location>
            <begin position="285"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="4">
        <location>
            <begin position="813"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120535" checksum="6D199E11DE8D0C69" modified="2011-04-05" version="1">MSKVSGAVDPLSSLSTLQAALIGARLLLLVGLASWSCSASAAQQQSTATQPPQDVTILSPGSVQAIHLAVGEARTYKIILSPQQSLRLVLTQGEHFQKLILHGPRITGSTRTNDSGSGASIPSTLTNASPAGSPASEYTLAIQSYHSNESSEGSLDLSPASFSLPEAQQRATAEDLFYDAEYLRRSANAKQWPHANDEFQQSLNLIQPLKDQYFTLAILTEQSRLLLFRLNDYVGAQRVAAQAAAVAAQLDTNSSSALYSDRSILTLKALCLKTLGSADYYLSDYPSAILHSNQSLAIYQQLNDLYWEGILRGNLAYVYFESGDTPAALETAARASAIADQVHDEYGRVYTLEALGSIHLARDEFDQAYDSYQQALTLTRKTPYPAIEALIWRGLGRFYQEVGKADLAEDAYQQAVTSAKKASDTAALLEITSELAALERSQGKLKAAHTAYDSGIALSGSSKLSREAVLLQSGLALTLAAEKKPREGIQQAGQAAALAQSIGYVEGEANATRDLAQLYLGLKDLKSARADYSHAAQLYEGIQDRVQTAHALAQLARIDVASDLQLAQTEEDHALDLIESTRVLVPGRELRTSYFADQQGVYAFGIELMIRLNRAYPNRHYVDRAFQIAEMARARSLLDQSSFFAEAANFSTTTPSPETASCELHLAAAYQRLHDLNVSDENANYRITRTQNEIQGQLAICDGLAGTAQSAKRQPETSLATLDSLQHSLSTQHASLIEYWLGDAESCLWYITAHGVKMLPLPPRRRLEAQVQSLTDSILARQSPIPGEDLAARTIRLEQSDRRAGDLLLQMGKLLLGPASGHPAGVLYIVPDGALASLPFAALTPQFKETPILLQGEVIEEPSSSVLLHLLDIHANSGGHPSSPYAAIAIFADPVYAADDERLPHQPAHLSQTALRSAFVLPELARLPASRAEADSIASLASGSSVETHIGFDASSHAILSTDWSRYQVMHLALHALIGQSPAFTGIAFSMFGRSGRTQNGMLWLNQIYRLKGAPGMVFLSACSTAAGKEIPGEGIDSLANAFLSHGSQSVIASLWSVEDQASSQLVRDFYYNLLTLHLPPGASLRRAQLSFVHSTQHRSPLYWAAFQLEGLPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X669</accession>
    <name>E8X669_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4173</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572865.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70953">
        <property type="protein sequence ID" value="ADW70953"/>
        <property type="gene ID" value="AciX9_4173"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4173"/>
    <dbReference type="HOGENOM" id="CLU_023205_3_0_0"/>
    <dbReference type="OMA" id="HFRSFER"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230775" evidence="1">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="54"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="37532" checksum="71A4FD935C969482" modified="2011-04-05" version="1">MERRDFLKSATAATAAIATKASAAAATPAPTTRPQSPDMIYRQLGTTGETVSAIGMGGFHLGKQKDPAESIKLIHAGVDKGITFLDNCWDYNDGISEVRMGQALKSSGYRQKVFLMSKMDGRTADAYNKQLEESLGRLQTDVIDLVQFHEIIRMEDPDRIFAAGGAIEAAVAARQAGKIRYIGFTGHKDPAVHLRMLETAQRHNFHFDTVQMPINVMDAHFRSFTHEVMPVAIKQGIGVLAMKTFGDHFILDSKTVQPMEALHYGFTQPVSVLITGIDNQQVLDQALEAARTFKPMSQAEVQSLLARTKEAASQGKYELFKTSAHFDGTAQNPKWLGETTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X670</accession>
    <name>E8X670_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572866.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70954">
        <property type="protein sequence ID" value="ADW70954"/>
        <property type="gene ID" value="AciX9_4174"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4174"/>
    <dbReference type="HOGENOM" id="CLU_033063_0_0_0"/>
    <dbReference type="OMA" id="PYGWNTL"/>
    <dbReference type="OrthoDB" id="1841091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="491" mass="55836" checksum="CA3EF3FB0936597F" modified="2011-04-05" version="1">MVPSPTPNPLSRLLIFPAVLIAALMAVVFVLAAFNTDPPITDPDVYWHLTNARHLVTTHHFIRADTDTFTVNGHPWINFEWLSELPYYYAFLHFGERGLFAVMMLLAEAIILGIFLLAWLRSHEIRAALLTTWIAALLATVSLAPRTLLFGWLCLIAELLILWTYKENKNYTWALPPLFFLWINLHGSWLIGFVFLLVFIAANSITVTWGSIATTAWPRPERNKWLLITALTFAALFLNPYGWRLVAYPLDVAFQQKLTLLYVEEWASLDFHLFRGKLMLAVLLGMAALNLIRRRTWLLADLLLASITIYAALTYSRFLFLAAIVLSPLLALDLKDLLGHQAAKPNKPLINAAAIAILIFGVAHLYPTQTRLHAQVAAVFPEAALPAIRALPPNARILNFYDWGGYLTWNIPTRPVFLDGRTDIFVHEGIMKDYASVLNANQVFEILDRYRITHVLFPRGGPFPYLLLHSPQWHLIYEDPQTQLFARQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X692</accession>
    <name>E8X692_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4197</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70976">
        <property type="protein sequence ID" value="ADW70976"/>
        <property type="gene ID" value="AciX9_4197"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4197"/>
    <dbReference type="HOGENOM" id="CLU_005679_1_2_0"/>
    <dbReference type="OMA" id="DFVQSWS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="44160" checksum="953F26C92E4CAEB5" modified="2011-04-05" version="1">MNHLAPGRPLLKPQSRLPGLDTLRSLAIVSVVIFHLAPFLPPSLSVVQRFGWIGVDLFFVLSGFLIGTQLLKPHAQGRPLGQSSILDFYRRRAFRILPAYLTVVALYLFVPLWREQPHLPAAWKLLTFTSNLFMHYPAELAFSHAWSLCIEEHFYLILPLAVLALTRRPSLRKTLAAFTVLLLAGICLRWWELSHIVRAASDDDLWPVFMKRIYYPTYTRLDGLLSGVALATLRLFRPQWWSRLESRGTATFLTGTLLVLAAMATLGFDYPSPDRTLGVLLAFPLLSLGFTLWVASALATNGPLKLRIPATEQLATLAFSLYLTHKAVAHVARQSIPWLTNNRTWPAAALTAILCLIAATLLYRMVEVPFLHLRDRNQALTTSPAAEPQTDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B7</accession>
    <name>E8X6B7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4224</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572913.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71001">
        <property type="protein sequence ID" value="ADW71001"/>
        <property type="gene ID" value="AciX9_4224"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4224"/>
    <dbReference type="HOGENOM" id="CLU_773314_0_0_0"/>
    <dbReference type="OrthoDB" id="1919281at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="358" mass="40085" checksum="862BEC590A44FF19" modified="2011-04-05" version="1">MEPTANPEGPARRAWGVILAWIGGITAVIGFIGTVTGTFTTLSDRLHRNSDFDAQIALAQAQVKQSEYPQAVQTYAAVLKQDPHYRPALDGQLQTVEHWVEDFRVPPREDEKTTVTASNLLDQIFPVLDAALVRTKALQTADIQAHIGWAHWLNQHIAEREFGSTAVDNLHAALVTDPNNVYANAMLGNWMLQNHQSLPEAIRHFDTAVATGKERPLVRRYQLAAYDNLDAPGGRTAILKAVSSMRQANEPLDSERRRNVFVYCCRPGTIFRNELVESFTALPQDEFWQTYLWLDADDPPEGEQIRQLNRRYIQASLAEVAGHRADALTQFRALKKDVQIPGTSLDELVAEAIQRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H8</accession>
    <name>E8X6H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572972.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71062">
        <property type="protein sequence ID" value="ADW71062"/>
        <property type="gene ID" value="AciX9_4294"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4294"/>
    <dbReference type="HOGENOM" id="CLU_131439_0_0_0"/>
    <dbReference type="OMA" id="YQAYLIT"/>
    <dbReference type="OrthoDB" id="1847229at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233742" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18482" checksum="8FFF81542F767441" modified="2011-04-05" version="1">MRIRSILTVCTLLLASLVNAHGQSILTRDQASAVMPATVFYAGRTASIQGRNSTGLRIAGSPTDHLILAALVDTSGYSSGVQETYQAYLITEVPLHIANQTLPPGAYGIGFIAQDHFVVMDLGAHQLLNVPSTKDATLPRPNPLQLLADPATPGHFRLYAGRNFVSIAPADVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M5</accession>
    <name>E8X6M5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3897</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582193.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71175">
        <property type="protein sequence ID" value="ADW71175"/>
        <property type="gene ID" value="AciX9_3897"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3897"/>
    <dbReference type="HOGENOM" id="CLU_803547_0_0_0"/>
    <dbReference type="OrthoDB" id="1073652at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="39757" checksum="4C92660D4A968E73" modified="2011-04-05" version="1">MTILWRFKELLKDLLLGKVRPAQKFFLGLEAPQKEITVWLHGRDAPLDVTNHHSLACASPFIICVAFEKGTKLKERELQVLSLHFCERENSRRLLGRIGLKYNGMSLPTKGPNLYFFQVSSASSYCLPLINLWMFYLQLRYRNWRYPSPPNTITLPSLQMRAMNILFICPRPIGLASAEEGSRGNMFPMNVMGQLDHGYFGFGLKEARSPSRLVARARRVALSTIPMQHGDLGYKLGPNHSKKTGIDWIDLPFATKRSRRYGIPIPEFALHVREMEVEVMKKLGSHIFFVGRIVEEERFSQWAEWCVIHGHYQTWRLRSRPVEIEFSIAEDARIKRGLIAESGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S5</accession>
    <name>E8X6S5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Precorrin-3B methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71225">
        <property type="protein sequence ID" value="ADW71225"/>
        <property type="gene ID" value="AciX9_3949"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3949"/>
    <dbReference type="HOGENOM" id="CLU_087913_2_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="12888" checksum="E0BE02D11F69B98C" modified="2011-04-05" version="1">MTPTQSIGIGCSSNATPEDILTLIHASIPTIFPATILATINRRAEIARTVAEALGINLLLYPAEVLAKIPSTLTTSQASLAHTGTPSIAEAAALAALGPLAHITLPRQTGHLCTCAVATIPSLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T0</accession>
    <name>E8X6T0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3954</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582248.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71230">
        <property type="protein sequence ID" value="ADW71230"/>
        <property type="gene ID" value="AciX9_3954"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3954"/>
    <dbReference type="HOGENOM" id="CLU_054359_0_0_0"/>
    <dbReference type="OMA" id="CWRGELL"/>
    <dbReference type="OrthoDB" id="1554168at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="123"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="47332" checksum="0DD8F4836C77F151" modified="2011-04-05" version="1">MSIKILLVASERWISTARLAMALIETGCEVYAVCRNDHPLLLISGLARRYSYRDLKPLKSMMNALRDAAPDLVICCNEETFRLAHRIHQLAVTKNDRVLKELLERSFGTPEHYSIELSRFGLMTLATEEQIEIPASLQVNSRFELEVAEEELGWPLVLKSDGSFGGNGVRIARDARQALTFWRRLRGPVGPLRTMNRVLMNRHLKPLYGMLRLQRHTVVAQRNIVGSEATLAASCWRGELLACHCMEVVESWNVRGPSSVLRVIESEPMLAAARTLIRRLGISGFCGFDFIVEATTGTPFLIEMNVRPTQTSHLALGPGKDLIVSLVRTVEANKNRQDLPTEDSEADTGWRAQVTHQEFIALFPQELQRDRESQWLRLGFHDIPLSEPALVKAATREPKKSWYESFKSNLPEAIRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X7</accession>
    <name>E8X6X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582108.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71086">
        <property type="protein sequence ID" value="ADW71086"/>
        <property type="gene ID" value="AciX9_3800"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3800"/>
    <dbReference type="HOGENOM" id="CLU_023194_24_1_0"/>
    <dbReference type="OMA" id="GAWEYTI"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="175"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="49395" checksum="DFC847DD8E0C1A6E" modified="2011-04-05" version="1">MHSIDRRKFLERAAKTTLLAGAATRLSPLFAQQPAPRSPNDNIQLALIGAGIQGQGDTKFALQVPGVKLVAVADCYDGRLTHAKELWGSDIFTTRDYREILKRKDVDAVLIATPDHWHKQAAVDSLRAGKDVYLEKPMIHLYSDGPEIIDAAKSSNRILQVGSQRVSSILYSKAKELLASGAIGKLNMVTARWDRNSSMGAWNYTVPLDASTETCDWPRFQGSAPKMAWNAERFFQWRKWKDYGSGVAGDLFVHLFSGTHFITGSHGPTRAMATGGIRFWKDGRDADDVLLALFDYPEGFNLSLHVNFVDGGEESEGFLFTGSEGLMEIDGRTNTVTVTRTPLAKEPGYTVSTFADAMQKASIAEYRKKYPVPHPGGPPPEGVQAFTAPPGYSDSYDHFSNFFASVRSRQPVVEDATFGFRAAGAALLSNLSVQKDSVVHWNPETMKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y4</accession>
    <name>E8X6Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3807</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582115.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71093">
        <property type="protein sequence ID" value="ADW71093"/>
        <property type="gene ID" value="AciX9_3807"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3807"/>
    <dbReference type="HOGENOM" id="CLU_036699_2_0_0"/>
    <dbReference type="OMA" id="IGNNPPN"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020043">
        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="PTHR42717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234468" evidence="1">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="47767" checksum="16C19C38B7D87946" modified="2011-04-05" version="1">MNRSLRIALALAACTQLAHAQLPAYDLILQGGHVLDDKNHIDAVMDVAVKDGKIAQVAPHLKSSDALKVIDVHGLYVTPGLIDIHVHVYNGTGERNSYAGDLSVPPDGFTFRVGVTTVVDAGCSGWRNFEDFKQRIIDRSKTRVFAMLNIVGSGMRGDKYEQNTKDMDGEATGAMALKYPQTIVGIKTAHFAGPEWIPVEQAVIAGTKANIPVMVDFGVDHPESRPIYELLTKKIRPGDIYTHMYSGLRHEQDPTTLGPSKAFIEGRKRGIFFDVGQGGGSFKWSLAVPMIKDGFIPDSISTDLHITSMNSAMKDELNVADKIIAAGVPVKDVIAEMTSHPAHEIKHEELGNLSVGSVGDIAVLRLEEGKFGFTDMINTRLDGTHKLVAEITLKDGKIVYDLNGMEAQPWTAKPDPNAKEAYHWTTFASAPHVVTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z9</accession>
    <name>E8X6Z9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxypyruvate reductase</fullName>
            <ecNumber evidence="3">1.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3822</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.81" evidence="3"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582130.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71108">
        <property type="protein sequence ID" value="ADW71108"/>
        <property type="gene ID" value="AciX9_3822"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3822"/>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_0"/>
    <dbReference type="OMA" id="GKAAWRM"/>
    <dbReference type="OrthoDB" id="1358712at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="342"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="467" mass="49682" checksum="5C0EA09F8DE62444" modified="2011-04-05" version="1">MYPQLLRQRLVKNTLSTNARQIFSTALEDCSVQQAFSLKLRGEMTHGICALHLKGTLAFDLTHITKILIVAIGKAALAMLDAFLPICPIPAGCTLGGVVIAPSAALQPKPGFSYFTGGHPSPNRESFTGAQTALDLLASAASKDHGQTFCFFLISGGASAMMELPLDPDISLDDTISFHQALVGSGASISEINCIRKHFSAVKGGRLALAAGKMRHLSLLLSDVPAGQLDALSSGPTLADSTTIEDCRKILQKFSLPSQFAPSVQSFFASSQLPETPKPGDFQENIFLLLSSEDLEGAARRHAEYLGFTTFIDNTCDDWDYRDAAYYLLNRIRTLQLQHGRVCLLSAGEVTVQIPTSPAGLGSSQGSEAPGMGGRNLHFTLYCASRLKSDERITILSAGSDGIDGNSVAAGAVVDASTLDGVPDEALQALQSFDSFRLLNRLGATVFTGPTGNNLRDLRILLADSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X703</accession>
    <name>E8X703_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor, plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582134.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71112">
        <property type="protein sequence ID" value="ADW71112"/>
        <property type="gene ID" value="AciX9_3826"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3826"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="RAPGYRI"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233761" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="519"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1131" mass="121642" checksum="EA978581BAB36363" modified="2011-04-05" version="1">MSMLCRRFPVFIFLLILSSYASIVFAQTVTGSIRGTIVDQSGAVVSGATVAARDVATGVIKTTITDRSGTYNLQTLSIGTYVVSATKPGFSVTTDKPFSLEIDQIARVNLSLAVGEVTTSVEVTDSGSLLQTEDSTLGTTITANTLENMPLSGQNFSSATLFVPGAVDPTYSAMGGANGSERDTSASTIPSFNGNRQQTNNYILDGADINEVINNVIGYNPAPEALQQIRVITGNANAEYGNVNGGEIIMVTKGGTNHFHGSLYSYYENQDLTANLWSNNYNHVAKGIFHQNQFGATIGGPILHDKLFFFADFEGFRNTAAGTGIASVPTARMRTGDFSEFLGVNSTVTTHIQLFNDHNGLSPATPYANNQIPITNPVAKYLFAHPEVYPLPNRVGVNPTTSPDSSNYQSNTKSVIVNNQGDVRGDYTLGTHDAINARFSMGDAWDATPQPVLLITFPGGSEYPFAGGVINEVHTFSSALQNAFRAGFSRIGWLQGEPVDATGQFGRSGDSMLGLPFPNQPYSGFSQVNLSSVESNIGTRGAATTYHDNIFDYGDDVTWLRGKHILKFGAQALRYQENNFYPSANGAMGLFSYNGTFTADTSAASTVPTGTKVAGYGFADFVLDQSSSQAVGGVSGPVGQRQYRLAFYAQDDWKLRSNLTLNIGLRYGFDQPITEVNNKQVNVDTDNPSTCPVCLQFAGQNGNSEALYKPYYKEFMPRVGFAYQLNPGVVIRGGYGITDDLEGTGANLRMSQNAPFIFQFANTSLTPTATSGGTPVPVENGFAQAPGNVSVASTRYQAWSHNLRPALIQQYNLASQVELNHKTTFQIGYVGEVGQHLIVPENVNQYTTNGVASTAPYAKLVGTGGLVYLTQSEGLSNYNAMQVTIRQRESHGLEYTFNYTWSKSMTNNPGFYGVSGVDGASVFPQNIYNPHGDYGVAATDSRNAVNFTAVYALPFGHGRDFGGNWNRLVDGALGGWKISGDAILYSGFPITIIATNVANANNGTARANQYLPLIIKNRTLTNWFGNDKSALPCTGASNGTCAYGPGTSLQFGTAHVNTERAPGYRIIDMSVFKEFRTFREQAFVFRADAFNAFNMASYAAPGNSVSTSTFGLITSTLSPARQFQFAAKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X709</accession>
    <name>E8X709_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3832</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582140.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71118">
        <property type="protein sequence ID" value="ADW71118"/>
        <property type="gene ID" value="AciX9_3832"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3832"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="ACNGSNI"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233762" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1182" mass="125687" checksum="DD0249C59602E969" modified="2011-04-05" version="1">MTWACSPSSRRRLVFGLAASAALFQTASGQTSTTGAIRGTVTDPQGAVIAGGIVTIKSQGTDAVRTALTDKGGQYTVGLLPPGMYTVTITAPGFKTEDPGSITVTVTETARVDAKLEVGSQSDTVEVSTATPALQMENATLGTVVDGDVINQLPLTNRNYTQVLTLSAGITGDLNNAATLGKGTPDVYVNGASNISNNFHMDGADINNFGSGRAGDFVQQAGIPIPNPDALEEFKIQTANYDAGFGRDAGANVDVVTKSGTNSFHGSLWEFLRNDVLNANDTFLKINGQKRPDMKQNQFGGTLGGPILKDKLFFFGTYQNTRQINGLSSTSLQTISLFPITNDRSAAAIGAAACPANAGPTPLAQTRWHPYVGGTYTGGVNVACNGSNINPVALNLLNQKLPNGTYLIPTPQRLLTDSNGNPIGQSTFSIPSTYFETQYMINTDYTISPKNTLSERYFYANYPEDQPLGTAGDTPGNGVSTVFNDQIGLLKLTSALTPHLLNEALVAYIRSSGHLQTESTLTASQIGMTAPSDPTYPLYPVTSVTGYFNLGGGGNDESSSVVNTFEIDDQISLTHGKQSIRAGFIGEKNQFDFNDPEQKRGSLNFSTFQDFILGQSAAQNGTNYSNVNTAGSQQGSYYKGYRGTDLAMFLQDDVKLRPNLTVNAGIRWELNSNVSFGHGEESSFWPSLVTRFQPLPAAGTLNGFIVPNNYQLPLPAGLTKIGSRSLTKNDIPLHNFGPRLGFAWQPYGAAATTVLRGGVGMFFTLPNGNSVLQTLGGQPFVSSASLSNAVDQASTFQTPYTATLTPGVWQVLSPTAVPRTVTAVAENSDSPLTVQYNLEVEQQLPEKLVLEVGYVGTRGTRLAEGRNINAAALASPTNPINGVTTNSTLSSNVQARVPYQGFSPTGVTLIETYGFSNYSSLQTTVKRQVSRGIYVQGAYTWSKAMTSVYGGDGTNGVFEGGSGNSNDPNNRYARYGLAGFDRTNRFVVAYTYLFPSWQKGNWFERAATSGWRVNGTSTFQGGKPLTITDSRNGTAYGETDSRAQFLPGMGNRNIVNKGGGTMLNRVKSNTYLNAGSAVFGLAPAVASAALNGTVNALDYGNSSVSAARGPGNDNWDMAVVKETRVGGIRENATLDFRTEFFNVWNHPEYSAPATAVSAASYGQITSSAGSPRLIQFALKYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X771</accession>
    <name>E8X771_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4353</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71305">
        <property type="protein sequence ID" value="ADW71305"/>
        <property type="gene ID" value="AciX9_4353"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4353"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_0"/>
    <dbReference type="OMA" id="RETIQAD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="302"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="531" mass="57580" checksum="8E219CB0DC39285D" modified="2011-04-05" version="1">MRAYGVLDTLPEQSYEDITKLAAFICETPISLISLVDSDRQWFKSERGLGAHQTPRSQSFCANTLVDAQTLIVTDARTDPRFKDNPLVLGDPNIRFYAGAPIVAPGGLVMGTVCVIDTEPRELSADQIEALEALARQVMVLFEHRTSIARVEEALGSSKEAQRHQGELAAIVSSSDDAILSKDLNGIITSWNVGASRIFGYSSQEMVGESILKLIPDELHSDETLIIGKVRNGERVEHFETERLTKDGRRIEVALTVSPVRDAFGNVIGASKVLRDISARKLIEKSLLQAEKIAAAGRMASTIAHEVNNPLEAVTNLLYLLRPLIVDTAGLAYLATAESEIARISNIAKQTLGFYHEHTAVSSVSVSDLVQHAVAVYEPRCTLNGIVIEKSLRSTQMLFLRQGETMQIVSNLIANSMYAMPSGGTLGVSTEDINGEDSGVLITIRDTGVGIAAQHIPKVFDAFFTTRSAIGTGIGLFVAKQFVEGHGGRIELQSNDDLQKHGTAVRIYLPLQTSYEGSPLLGSDAVPKQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X795</accession>
    <name>E8X795_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="3" type="ordered locus">AciX9_4377</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573048.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71329">
        <property type="protein sequence ID" value="ADW71329"/>
        <property type="gene ID" value="AciX9_4377"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4377"/>
    <dbReference type="HOGENOM" id="CLU_605151_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="44756" checksum="A941352F0CE7B7BB" modified="2011-04-05" version="1">MKKSENVSASGLSACARIVGASEMAGRVRNYIWRDTLLGPIEGWPHALVSSVNLALNSSVAAALYWGPELIFICNDASVRMMGDYLNDFLGLSAEKLWMEHWPNVEQQFRAVLTNGESFTGEGVPFTFKRANPSDEIHFTYSLSPIYDEGSVVGIYRTLDDMTGQVVAMRNLAEANERLRMALTAGCLGVWDWHIHTGIVYADETTAKLYSIDPNEAGTGVSNKLFERMLHLDDIAPLSDAIIGCITTGKEYSVDVRVNRGDGSYRWVRSMGRCVYDKNGHAYRVTGLKSDVTDLRRSESKPQAAQGTLLPIEAWEKLPLHMQSLLRGTLPFLVDSPDQIRLVVVPDVNGTQISLRVAATDLGKAIGKQGRTIRAFRTILQAVNGIGEHRYSIDIESRAASDSNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D7</accession>
    <name>E8X7D7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71371">
        <property type="protein sequence ID" value="ADW71371"/>
        <property type="gene ID" value="AciX9_4423"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4423"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_7_0"/>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="35712" checksum="F420501DC5BF76F5" modified="2011-04-05" version="1">MKAAVYDSKLSSPDRLVEIMEVPRPTPVAGHLLLRVLACGVCRTDLHIVEGDLPALLPRIIPGHQIVGEVVDVGTVRLPLGTRVGVSWIGGTDGNCWFCRNQMENLCDHPVFTGYSVNGGYAEFVLVREDFVFPLPGPLDGAQIAPLLCAGIIGFRSLRIAGVLPGERVGLFGFGSSAALAIRILQFWKCEVYVVTRGKAHRDSATALGATWVGAEDAGPPVQLDRAITFAPSGKVVIDALRCLRKGGVLAVNAIHLDQMPAFDYDKLLWGERQIRSVANMTRDDARDFLELAQQLQFQPRVTIFSLVDAHKALAAVKNEDESGSIVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H5</accession>
    <name>E8X7H5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573128.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71409">
        <property type="protein sequence ID" value="ADW71409"/>
        <property type="gene ID" value="AciX9_4463"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4463"/>
    <dbReference type="HOGENOM" id="CLU_1523077_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="18580" checksum="6FE0B19C51B5D59C" modified="2011-04-05" version="1">MSVLIFGVLIAAALAAITIPLSVRYGSPAMLKNLSLVKTGLLVLAAVCSGLLSLISLAAAAWGMNTSLPWGLGIFMYLIPALGFPAFVILKFGSVRLLSRVLWLMTLASSLAFYFGDQADRLASGLRPITNPTERLGMFANAFTIVLVGIAVLVQAASICASREKRVLEANLVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J0</accession>
    <name>E8X7J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573143.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71424">
        <property type="protein sequence ID" value="ADW71424"/>
        <property type="gene ID" value="AciX9_4478"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4478"/>
    <dbReference type="HOGENOM" id="CLU_129888_0_0_0"/>
    <dbReference type="OMA" id="NWGKEMW"/>
    <dbReference type="OrthoDB" id="1845862at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234484" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="18928" checksum="6DC5A0226622F2E8" modified="2011-04-05" version="1">MKHFIRSLLLALTIPLSVSSIAQSPSGAEGNSAPAGLASDTVDVQHVMGAYHEAVLAHDGARLASLFLPQCTLWLNVLSDDAYARVKAKKHDAVKVRLGSYTDFAKLVSASKVSFNPTHTHLQLNSDGTVASAYFDYVFLIDGKEQNRGSETWVLVKGADGWRIAAVTYSSNPHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V1</accession>
    <name>E8X7V1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573254.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71535">
        <property type="protein sequence ID" value="ADW71535"/>
        <property type="gene ID" value="AciX9_4605"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4605"/>
    <dbReference type="HOGENOM" id="CLU_035706_0_0_0"/>
    <dbReference type="OMA" id="RSVIWRE"/>
    <dbReference type="OrthoDB" id="1780129at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="221"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="43743" checksum="0889C35394E074D8" modified="2011-04-05" version="1">MREGRRFGLSAEHKADIWRRWKLGESLKEIGRAFDKDHGSIQFMLSKHGGIAPAVRERSQRTLTLVEREEISRGIASGSSIREIAKGLERPASTVSREVVRNGGRSVYRASDADQRAWRSALRPKTCRLARHRKLRLIVASKLIRDWSPEQISGWLKRRYPNNGSMRVSHETIYRSLFIQARGVLKKELVQHLRSKRQIRRSVHAKAAGQSRGQIVDAISISERPAEINDRAIPGHWEGDLLSGSGNSHIATLVERHSRFTILVKVPSKDTATVVAALSRQVRKLPASLRRSLTWDRGLEMAKHKSFTVATKVDVYFCDPQSPWQRGTNENTDGLLRQYFPRKTDLSGYSQADLNKVALRLNQRPRKTLDFDTPASKLQASVASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W2</accession>
    <name>E8X7W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4616</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573265.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71546">
        <property type="protein sequence ID" value="ADW71546"/>
        <property type="gene ID" value="AciX9_4616"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4616"/>
    <dbReference type="HOGENOM" id="CLU_2046359_0_0_0"/>
    <dbReference type="OrthoDB" id="2157221at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="120" mass="13663" checksum="BC5DC6E05CCC2249" modified="2011-04-05" version="1">MAPTRELWTSNLVDAARAIGDTERQRSRWLAADAFAWERPEELINTWDDSLVELFLEEYGAGLSRAQANAAIALRDELNKYCHATPDILDPLQVLTDPRWEAVRIKARSFVTAFETNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV78</accession>
    <name>E8WV78_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding S4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0179</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578581.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0179"/>
    <dbReference type="EnsemblBacteria" id="ADW67253">
        <property type="protein sequence ID" value="ADW67253"/>
        <property type="gene ID" value="AciX9_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0179"/>
    <dbReference type="eggNOG" id="COG1188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101003_2_1_0"/>
    <dbReference type="OMA" id="IDKYLWC"/>
    <dbReference type="OrthoDB" id="2006597at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="15387" checksum="8F2FC8E3A5D1B08C" modified="2011-04-05" version="1">MATEELNAVRIDKWLWAARFFKTRALASDACEIGRIECNGQRAKASRVLHVGDKLKVKNEGGEYQIEVLLAAEARGSGAVAQTYYQESDESREMRQKLADERRELLKQGMLPEGKPTKQNRRQLDKLRGRIHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC8</accession>
    <name>E8WVC8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578631.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0229"/>
    <dbReference type="EnsemblBacteria" id="ADW67303">
        <property type="protein sequence ID" value="ADW67303"/>
        <property type="gene ID" value="AciX9_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0229"/>
    <dbReference type="eggNOG" id="ENOG50334DF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969458_0_0_0"/>
    <dbReference type="OMA" id="MQRCVDE"/>
    <dbReference type="OrthoDB" id="2091469at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="12186" checksum="C62968A3A24E4243" modified="2011-04-05" version="1">MRRSVQVAAPLLASAALTLLTACRKPEMQRCVDENNRVVADNLCSNPTSGTPSAVYHPGMGYIPMYRYYYGGGGGYSLGSGAFGGGYSTLSGHSYANSTGTIRGGFGSSFSGGHGGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN3</accession>
    <name>E8WVN3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-type ATPase subunit c</fullName>
            <shortName evidence="10">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpE</name>
        <name evidence="12" type="ordered locus">AciX9_2532</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580877.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2532"/>
    <dbReference type="EnsemblBacteria" id="ADW69562">
        <property type="protein sequence ID" value="ADW69562"/>
        <property type="gene ID" value="AciX9_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2532"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_2_0_0"/>
    <dbReference type="OMA" id="YCFVISM"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017708">
        <property type="entry name" value="Alt_ATP_synth_F0_Csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03322">
        <property type="entry name" value="alt_F1F0_F0_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="11">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="10">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="9672" checksum="3325B7711E668ECA" modified="2011-04-05" version="1">MDSTTAIAIASIVTAGLTIGIGCLAPALGEGKSVATALTSLAQQPDASATITRTLFVGLAMIESLAIYCFVVSMILIFANPFWKFVIAHAVQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR3</accession>
    <name>E8WVR3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2565</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580907.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2565"/>
    <dbReference type="EnsemblBacteria" id="ADW69592">
        <property type="protein sequence ID" value="ADW69592"/>
        <property type="gene ID" value="AciX9_2565"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2565"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361219_0_0_0"/>
    <dbReference type="OMA" id="ASWHEVP"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="810" mass="89415" checksum="B15F35615DB0C4F4" modified="2011-04-05" version="1">MVYLFEKFELDDSGFCLFHEGRRVPLEPRALRVLLLFVQNPGKLLQKDFILESVWKATFVEESTLTRAITILRKQLGDDSRAPTYIETVPTLGYRFIAKVETLSAAEPGETHPDAKPSVNQTLEPLPHPLTLEADQDRFPPFAKVNEVLTPNPLSRKHEGRSVKWRNWYLLAVLLPVAGGAELWIHFHHQPILEEKKAVVLSDFENSTGDAVFDGTLREGLTVQLEQSPVLSLISEPRIRNTLRMMSRNPETRLTPVLAREICQRTDSAAMLDGSIASLGSQYVITLHATNCNTGEVLYTEQVQAARKEDVLHALSTVASNLRSRLGESISSIRSLDTPLDEATTSSLDALKAFSESARVENESGSAAAIQLAQRAVELDPKFAAAWAILGRLYGDIGQEKSSAESTAKAYEFRDHASDHERFFIVASYEMQVTGNLEKAEQTCETWAQVYPNDAGSYGFRAGLILRVFGQYDKAIENAEHLVGIHPDFAMAYHFVALNDIALGRYKDAQRIGERASARNFKIPYYALDQFRLASLTGDEAAMQRVVTMAAKMPGSEDMIAGQQASSFASHGQLEKARAVSAGAITFMVQSGRREAAARAESGSALREAFLGNRDQAKRLALAALSLSKGRDAQYGAAFAFALSGDSIKAEALASDLEKRFPEDTSVRFHYVPTLRALVALDRHDATKAIELLQANIPYELGSPQSSFSGFYGVLYPVYVRGMAYLMMHRGNDASTEFRKVLDHPGIVANDPIGALAHLELGRAYVQSGNSVGAQAAYKDFLALWNAADQDLPLLKQSRLEFARIEDRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW70</accession>
    <name>E8WW70_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1394</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579775.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1394"/>
    <dbReference type="EnsemblBacteria" id="ADW68453">
        <property type="protein sequence ID" value="ADW68453"/>
        <property type="gene ID" value="AciX9_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1394"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_0_0_0"/>
    <dbReference type="OMA" id="NWHLSSA"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="27391" checksum="53116C26B5131684" modified="2011-04-05" version="1">MSKKKHPEHVNHERWLVSYADFITLLFAFFVVLFASGQNDKRKQVMLAHAVQSAFMHNGIFDQHSKTPPITTDGNSSLNLATAPIALPVPSAAESAEATEIRLKEVVKAQVEKKQLTSDAVSVRATGDGLVVSLREAGFFASGSADVRPEALAVLQTVAAALPRQSMRVEGHTDNIPIHTTQFATNWELSTARAATITRLLIAQNAVDPAQVSAAGDAEFRPIADNATDAGRAQNRRVDIILLKAAAPTTQAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW92</accession>
    <name>E8WW92_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ordered locus">AciX9_1417</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579797.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1417"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="ADW68475">
        <property type="protein sequence ID" value="ADW68475"/>
        <property type="gene ID" value="AciX9_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1417"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_0"/>
    <dbReference type="OMA" id="KKMNPVM"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="596"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="807" mass="89860" checksum="6AE6642538F7909E" modified="2011-04-05" version="1">MKTSEEQKLSRDVRKLPMMPIREMVIFPHMMTPFVVGRESSVRALEEALTGDRKIFLATQHDASMDEPNADDIFEVGTIGNIVQSVKMPDGNIKVLVEGVERARAVEMNDEDGFFVATVRTGPTHLEMTPQVEAMMQRVHTLFEQYVKLQQSLNYETMAASVRGDEPSKLADTIAANLQLSIEEKQELLEVFDPEVRLSKIADVLDVAIEKLNIDRTVQSRVKRQMEKAQKEYYLNEKIKAIQKELGRGEKSEFDELKKKIETAGMPKDVLEKSMQELKKLEAMPPMSAESTVSRNYLDWLLAVPWRKRSKEIRSIQLAEEVLNKDHYGLEKIKERILEFLAVRQLVKNPKGSILCFVGPPGVGKTSLGQSIAKATGRKFVRMSLGGVRDEAEIRGHRRTYIGALPGQVIQSMKKAGTKNPVFMLDEIDKMASDFRGDPASALLEVLDPEQNNKFQDHYLDVEYDLSQVLFVATANVLDTIPGPLQDRMEIIRLSGYTEIEKLEIAKQYLVKKQREGNGLTEEQIQFEDGALKSLIRGYTREAGVRNLEREIGNVGRKVARKVVQDGPEHKELVTAENLESLLGVAKFRDSEVHKKSEIGLVTGLAWTSVGGVILQTEVQVLDGKGKLTATGQLGDVMKESAEAALSYTRSRAAHLGLSKEFYRHVDIHVHVPEGATPKDGPSAGITIATGLASALTKIKVRRDIAMTGEITLRGKVLPIGGLKEKLLAAHRAGVFEAILPADNRKDLADLPDLIKNTMKLHFVEEMDEVLQIALEEKLRPLEEETPEALAGVIPPVVAGPQSSAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW94</accession>
    <name>E8WW94_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ordered locus">AciX9_1419</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579799.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1419"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="ADW68477">
        <property type="protein sequence ID" value="ADW68477"/>
        <property type="gene ID" value="AciX9_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1419"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_0"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="197" mass="21883" checksum="5A25C65B1296F39F" modified="2011-04-05" version="1">MGLIPYVVEQTSRGERTYDIYSRLLRDNIIFMGTPIDDNVANVIIAQLLFLSGEDPEKDIQMYINSPGGSITAGLAIYDTMQYIKNDVMTLCIGQAASMGAFLLMAGKQGKRFALPNSRILIHQPSMGGLSGQATDIDIHAREILRIREITNTLMSKSTGQPLAQIERDVERDFIMTAPQAKEYGIIDDIIDRPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA4</accession>
    <name>E8WWA4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1429</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579809.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1429"/>
    <dbReference type="EnsemblBacteria" id="ADW68487">
        <property type="protein sequence ID" value="ADW68487"/>
        <property type="gene ID" value="AciX9_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1429"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_0"/>
    <dbReference type="OMA" id="GWWQQNG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="310"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="44696" checksum="84CD1C09AFD05A38" modified="2011-04-05" version="1">MRFELFIAARYLRAKRRQAVIGVITAISVLGVAAGVASLIIALAITNGMRRDLQERLLGSTSHVELMRVSADGIRDWRPLLDKLRALPHVTAAAPGLYGQVLISRGARSGGGLVKGVIPADEEKVSDLLQAVTRGSSRPLQPQVNPDAGDAQATPPIVIGKDLAETLGAEVGDTVLVTSPQGELTPLGLVPRYQRFQVVGIFASGFYQYDSSYTFVRLTDAQRLFSEPDLISVISFKVDDLYRANIIGRTIEETAGKGFQATNWMEQNRELFRALKLEQIVTFIVLALIVCVAALNILIALTMMVMEKTKDIAVMMSFGVTAAQVRRVFLLQGLMISVIGTGVGLVVGYGISLAGGHYRFPLDASVYSIDYLPFAPRFVDALIVAGVSLGVSAIATLYPSSSAAKVLPAEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF7</accession>
    <name>E8WWF7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2596</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2596"/>
    <dbReference type="EnsemblBacteria" id="ADW69621">
        <property type="protein sequence ID" value="ADW69621"/>
        <property type="gene ID" value="AciX9_2596"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2596"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_1_0"/>
    <dbReference type="OMA" id="RDRVNIY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10337" checksum="1586E524EB5D1686" modified="2011-04-05" version="1">MRHDLIKQDLIQRVVERTGLVRTKAEAAVDAIFESMKQSLVEGERIELRGFGVFTVKPRKTGVGRNPRTGAEVSIAPGKAVRFKPGKDLHVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP4</accession>
    <name>E8WWP4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ordered locus">AciX9_3789</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582097.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3789"/>
    <dbReference type="EnsemblBacteria" id="ADW70789">
        <property type="protein sequence ID" value="ADW70789"/>
        <property type="gene ID" value="AciX9_3789"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3789"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_0"/>
    <dbReference type="OMA" id="RMASVNG"/>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5885" checksum="8DBD87369A7BE7C9" modified="2011-04-05" version="1">MPKRTFQPNRRHRAKTHGFLTRMKTKAGAAVLNRRRAKGRHKIAVSAGFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW3</accession>
    <name>E8WWW3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="18" type="ordered locus">AciX9_1471</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579844.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1471"/>
    <dbReference type="EnsemblBacteria" id="ADW68524">
        <property type="protein sequence ID" value="ADW68524"/>
        <property type="gene ID" value="AciX9_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1471"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_0"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="428"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADW68524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="662" mass="76141" checksum="27ADF592548CAA3C" modified="2011-04-05" version="1">MDFQLTTPYTPQGDQPRAIGELVAGLAAGEKDQVLLGVTGSGKTFTMAKVIEEVQRPALILAHNKTLAAQLYHEFKQFFPNNAVEYFVSYYDYYQPEAYIPSGDLFIEKEATINEELDKLRLSATRSLFERRDAIIVSSVSCIYGLGSPEAYYGMLLLLEKGQKIKREDITRRLVEILYERNDVDFRRGTFRVRGDIIEVFPTYDENAYRIELFGDEIDGLSQIDPLFGTVRQKYSRLPIYPKSHYVVQPERKKAASDSILAEMEWWEKELENTGRLVESQRIHQRTRFDLEMIKSVGYCHGIENYSRHFSGRLPGEPPPTLLDYFPRDYLLFIDESHVTVPQLHGMWHGDRSRKQNLVDYGFRLPSAMDNRPLKFDEFEGRTGQIIYVSATPGPYELTKAAGVVVEQIIRPTGLVDPQIEIRPVKGQIDDLLAEIRIRAANDQRVLVTTLTKRMSEDLANYYTEVGVRCRYMHSEIETLERIRLLRDLRKGEYDVLIGINLLREGLDLPEVSLVAILDADKEGFLRSQGSLIQTIGRAARHLEGRAILYADKMTDSMQRAIDETDRRRTKQEAYNEEHGITPRTVIRSIDDSLATILKADYADLTEDTQGMPDFNTQAELDTYIKNLESDMREAAKKFEFEKAAKLRDTVRELRTKEFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY9</accession>
    <name>E8WWY9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1497</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1497"/>
    <dbReference type="EnsemblBacteria" id="ADW68550">
        <property type="protein sequence ID" value="ADW68550"/>
        <property type="gene ID" value="AciX9_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1497"/>
    <dbReference type="eggNOG" id="COG4994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119560_0_2_0"/>
    <dbReference type="OMA" id="YWEVGAS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="17646" checksum="8387F40E7A495004" modified="2011-04-05" version="1">MRTAQPAYNSVVEKNPVFTYTEPELLPILEELRRREPIFHSPEFGTSVADFERSTATDYWEVGASGRRYSRDFILQDLYGQPPVFADSLGWKSWDYALRRLGPDTYLITYVLLQGDRLTRRATIWQSVRDGWRILYHQGTVVLAEEDDVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX51</accession>
    <name>E8WX51_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2669</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581008.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2669"/>
    <dbReference type="EnsemblBacteria" id="ADW69693">
        <property type="protein sequence ID" value="ADW69693"/>
        <property type="gene ID" value="AciX9_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2669"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008630_0_0_0"/>
    <dbReference type="OMA" id="VIQWVHR"/>
    <dbReference type="OrthoDB" id="126943at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04276">
        <property type="entry name" value="ZnMc_MMP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033413">
        <property type="entry name" value="DUF5117"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032534">
        <property type="entry name" value="EcxA_zinc-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034032">
        <property type="entry name" value="Zn_MMP-like_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16313">
        <property type="entry name" value="DUF4953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17148">
        <property type="entry name" value="DUF5117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230023" evidence="2">
        <location>
            <begin position="19"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5117" evidence="4">
        <location>
            <begin position="85"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4953" evidence="3">
        <location>
            <begin position="414"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="832" mass="91559" checksum="15CDA674FEAAA63A" modified="2011-04-05" version="1">MRPAFLLALALPATSVLAQSPESKPTPTIAAKTATMVHMPGLLPLDWDARAGKLYLEIPKLNYDILYTNSLPHGTGSNDLGLDRGQTSGGKIVHFERSGPKVLLVEPNQEFRSSSDDPAERLSIHQSFPESVLAGFKVEAENPDGAVLVDATDFFVRDAHGVIETLTTLKQGAFKLDASRSTIELDHTKAFPKNTEVEALLTFTSETSPGRRSYVADVTPDPHALTLREHQSFLELPPPGFTPRRFDPRAGYFPSSYRDYSAPLGEELDQRFIIRHRLIKKDPSCTKACEPVTPIQYYVDRGAPEPIRTALVEGARWWDQAFQAAGWAKGTFRVDPLPADADPMDVRFNIIQWVHRYTRGWSYGAAIADPRTGEIIKGNVTLGSLRGRQDYLIAEALLSPYVKGAPAITPSNDPMLAMVLQRIRQLSAHETGHTLGLAHNFAASAFPHTDLDETISVMDYPHPYIFLNKGGVPDLSHAYPVNIGSWDKVAIDYGYREFDRSGSAVERPAALNQILADSEKKGLIFITDEDSRPFSGAHPHAHLWDNGADPADELIRILDIRAKAIARFNANAIKPGMPMAQLEDTLVPLYLLHRYQTEAAIKEIGGLDYRYQLRDDGQINPTIVSPEDQNKAIAAVLKTLTPDTLTLPESLLQILPPRPPGLRRTQESFPSETGLTFDPIATAESAADLTLAVLFDPARASRLVQYHMRSPKAPSLRGLMEAVSKTTAERPEGGHTMSSEVERAVEFRALEAMFTLAVNPTASSQARAIAHSHLEDVLKQFTSAAPLTDTAEAIHRAAMIDRINDFNRDPEKFVPAKSIEAPPGMPIGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC2</accession>
    <name>E8WXC2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0383</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578783.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67455">
        <property type="protein sequence ID" value="ADW67455"/>
        <property type="gene ID" value="AciX9_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0383"/>
    <dbReference type="eggNOG" id="ENOG502ZTV2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1693023_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17488" checksum="B790BAA803C7730B" modified="2011-04-05" version="1">MITVPLGSLLNGFATTEWGACLEAAPADSGTHVYAIIVTANTGQFPLYVGQTGRLCDRIGDYTTAQFHAPTDFRVGEAIKYLRTQKPCRVDFFYRPSEAHLQDEKVLIREFLLAGYTLLNFLAAFDYKTANRDEERSLIHKFCDMALLRSKIERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC8</accession>
    <name>E8WXC8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0389</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578789.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0389"/>
    <dbReference type="EnsemblBacteria" id="ADW67461">
        <property type="protein sequence ID" value="ADW67461"/>
        <property type="gene ID" value="AciX9_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0389"/>
    <dbReference type="HOGENOM" id="CLU_2478978_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9548" checksum="7373F7AD5B904BBF" modified="2011-04-05" version="1">MTIPEAVEIAKKHLVEVMPDLASSTIELDELETPPSGSAWRFTFTAIRPSDPNNSNVLELLRSRRSTKSVEVNSVDGSLLAIRNRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD4</accession>
    <name>E8WXD4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0395</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578795.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0395"/>
    <dbReference type="EnsemblBacteria" id="ADW67467">
        <property type="protein sequence ID" value="ADW67467"/>
        <property type="gene ID" value="AciX9_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0395"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014750_1_0_0"/>
    <dbReference type="OMA" id="YSEFYQP"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="82"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="908" mass="97622" checksum="12794882E12251AB" modified="2011-04-05" version="1">MVFGLASACFAQSGGAGAVQGGAPGGKNAGDQQHVNQSQAPDTKTASGSDTKDYASGRTVKVSPLAPASAPAKVFARPRIGLALGGGGALALSEIGVLRWFEEHHIPVDEVAGTSMGCMVSALYSTGRTPEELTGVMNDKVFTSVFSLSQTYTSKSFRRREDSRELPNAITIGLKHGVSFRNAVLLDQGLNSFLDRQFLRYDDQVDFNALPIPLRCVSTDLNDGVPVTFARGSIPDAIRASVSLPGVYKPFEMDGHEYVDGGVLDNLPTSSVKAMDADVILAVSLPLSPLDKGGLDSILGVLQRSFSVAIEGAEREQRKMANVVMMPDVSGYTAADYLKTAGLAKRGYAAAEANKDALLKYAVSDADWQEYLVHRRSLRRGPAAPVLRVRVKAPNASATLAVQRLFMPLVNQPVDTRKIETLLDQVRADGRYDADYTVGYETEAEFRAQQSGAGLGKKGTVDVPVATSTSQLPAKDQDSLKAELNQQPNAAPQSANGQRAGAPVPNPNAPSTGGQPGLTAAVADAPDQKGLAATQRVTNESLADVADRPIILVTVADKKTGPPFLELGANVRAQTTAVTRATLQAIVLDQDLGGYGNELRTSVRVGYETAIDTEFIHPFNAVSSPGFNYFVAPHGQVLRQPEQIYSNQVRLADRLLQRFGVGGDIGVSNQRTQELRAGYDFTNIRWDLLVGQDNAATFYGNSQRARVRYAYDDQDRALIPQYGVRFVTEAAYLFDAVGSHNAPQITAEGTYAHRFRLPGEAKTFMPKKSAPDDVVEAKPNQGKEIFAMAVDSGTMFHRSVAQPFLYTLGGPVRLSASAIDEYRGTDYWLVEPGLLRRIAQLPQPLGQSIYVGLVYEAGQMYAPGQRTITRQDVFLGLAAETPLGVITFGPAIGDHNERKFVFTLGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE2</accession>
    <name>E8WXE2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0403</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578803.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0403"/>
    <dbReference type="EnsemblBacteria" id="ADW67475">
        <property type="protein sequence ID" value="ADW67475"/>
        <property type="gene ID" value="AciX9_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0403"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_0"/>
    <dbReference type="OMA" id="QIYIAIE"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="13163" checksum="F55CD23544DFF07C" modified="2011-04-05" version="1">MRSHRQLTVWQRAIELAFAIYDLTKHFPPDEHFGLTSQLRRAAVSIPSNIAEGQSRDTRGEFRHFLGISRGSLAELQTQLVLAKGLHLGDPTAIDNCESLATEVTLMLIALQNSLPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF8</accession>
    <name>E8WXF8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0419</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578819.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0419"/>
    <dbReference type="EnsemblBacteria" id="ADW67491">
        <property type="protein sequence ID" value="ADW67491"/>
        <property type="gene ID" value="AciX9_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0419"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254463_0_0_0"/>
    <dbReference type="OMA" id="AHVHRIV"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="216" mass="24409" checksum="38B941AE3327F409" modified="2011-04-05" version="1">MTKGFLQPQQQRSRETLARLITATLTTLEEHGLEGATIARIAGVAKIAPASVYRRFRDRDALYRVALLHVLERAADQDVVNEHSGGQTLEAHVHRIVSLTLQQFTLQPGLMRALTRFVESDSDEEFRTRALRSISISYERLTDGLLAYRERIVNPDPRKAITFALLTMGTVIEVRALEQVSMWNELTQLSDEDFVTEVSRSFLGYLGYSGSDVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH0</accession>
    <name>E8WXH0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0431</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578831.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0431"/>
    <dbReference type="EnsemblBacteria" id="ADW67503">
        <property type="protein sequence ID" value="ADW67503"/>
        <property type="gene ID" value="AciX9_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0431"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_0"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="358"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="665" mass="72484" checksum="502F9769A99243CB" modified="2011-04-05" version="1">MSDTQQHELDQLSINTLRFLAVDQVEKAKQGHPGAPLGCAPIAYLLYTKYMKYDPKDPLWSDRDRFVLSNGHASALQYGALHLAGFDLPMSQLEQFRQWGSHTPGHPEYGETPGVEVTTGPLGQGLAEAVGLAIAEKHLAALYNHENHTPVDHHTYVICGDGDLMEGISHESCSLAGTLGLGKLIVLYDDNLISLDGPTELSYTEDVTKRFEAYHWHVQMVDDGNDLKALEDAIENAKAATTRPSLIRVRTVIGYGSPKAGTSKVHGEALGPEATKETKRNLGWPEDKSFYVPEEAGKNWHEKSVVRGKKLHEEWDKTFAEYTKAYPELGAEYSRVTEHKLAAGWEKALPVFPTDKPIATRTAGNVVMNAIAKVVPELFGGAADLTSSTKTIFKDSPSFHVDPKGRNVFFGVREFGMMAAVNGIAAHGGLIPFGSTFFTFSDYCRNAIRMGALQSSHSLYVFTHDSIGLGSDGPTHQPIEQLASLRLIPQLTDFRPADANETTTCWQLMLERQSASVLVLSRQDLPVLDAAKYKTAEGVRKGAYVLEAYGKDLILVATGSEVEMIMKAALTLKEEGILATVVSMPSFKIFEEQDEAYKLSIFPHGAPTISLEAGATMGWYKYVGRDGIAIGVDRFGASASAPEVQDKLGISASAVVTAAKKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ9</accession>
    <name>E8WXJ9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer-membrane lipoprotein carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1562</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LolA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1562"/>
    <dbReference type="EnsemblBacteria" id="ADW68615">
        <property type="protein sequence ID" value="ADW68615"/>
        <property type="gene ID" value="AciX9_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1562"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087560_0_0_0"/>
    <dbReference type="OMA" id="GLMRWEY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018323">
        <property type="entry name" value="OM_lipoprot_carrier_LolA_Pbac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00547">
        <property type="entry name" value="lolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234145" description="Outer-membrane lipoprotein carrier protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24598" checksum="E9B38E04F79BB71B" modified="2011-04-05" version="1">MHLKRYLTLQSQITLSLALMLAASAAAQSPQDALLQKVDDHYNHLASLRARYREHYTGMGMDRSESGTLLLKKPGRMAWHYDVPAGKLFVFDGKFAWFYTPGDPQAQKIPAKQMDDLHTPLRFLLGHTQLKKELDQIKVTPVGTEFRITGIPKGMQQRIHQLGLQVTPEGLITAMQVEEIDGAKTEFTFTEMKENIPATNADFQFTPPPGVTIITGAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK4</accession>
    <name>E8WXK4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1567</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579939.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1567"/>
    <dbReference type="EnsemblBacteria" id="ADW68620">
        <property type="protein sequence ID" value="ADW68620"/>
        <property type="gene ID" value="AciX9_1567"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1567"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_1_0"/>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="36585" checksum="C6E04E6C57E6C140" modified="2011-04-05" version="1">MTPPHTTPLRVVAIGGGTGLSTLLRGLKRYVAAPIGTAPPNNQDPACKDLPCLIRDLAAVVTVTDDGGSSGRLREDFKMLPPGDVRNCMVALSEDEHLLSKLFQFRFAQGDLQGHSFGNLFLAALSHITGDFAQAVQMSSQILATRGVIYPATNTDVTLSARMDDGTIVNGETNITASQRRIVELTLSPADAQPLPEAIEAIRNADLITLGPGSLYTSLITNLLVKGIPEALAASKATRVYVCNLMTQANESIGLTASEHIEKILQHAGGHPIFDYALINTAPISPTLLAQYAREGQQPIEPDLARIRSLGVEPITGPFVHEGDVLRHDYDKVTDSLLKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP3</accession>
    <name>E8WXP3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease III</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nth</name>
        <name evidence="5" type="ordered locus">AciX9_1606</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579978.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1606"/>
    <dbReference type="EnsemblBacteria" id="ADW68659">
        <property type="protein sequence ID" value="ADW68659"/>
        <property type="gene ID" value="AciX9_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1606"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_0"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="4">
        <location>
            <begin position="99"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="30152" checksum="FC13A9C50DE2C063" modified="2011-04-05" version="1">MPSVKKTVAKKSAAKGLVPPQRLSGASRKAAIEGVPAEKAHEIASSEPVFPKLKNGRTAKPLAQDRVAAILDGLRKTYPGVVCALTHRNAFELTIATILSAQTTDVGVNKATPELFKMYPTPKKLAEAPTLEVERLIKTTGFYRAKAKNIQGAARVLVERFGGEVPKTIAEMIELPGVARKTANVVLGSWYGIASGVVVDTHVLRLSRRLELTKNDDPVKVEQDLIKVIPQDRWIQFSHELIHHGRQVCIARKPRCVDCSLERVCNSTDKTWSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR3</accession>
    <name>E8WXR3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2734</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2734"/>
    <dbReference type="EnsemblBacteria" id="ADW69758">
        <property type="protein sequence ID" value="ADW69758"/>
        <property type="gene ID" value="AciX9_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2734"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_1_2_0"/>
    <dbReference type="OMA" id="VTFVWNE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10968" checksum="DEB41A8834DB8219" modified="2011-04-05" version="1">MLDGQRFVWDSDKAARNLAWHGVRFEQAREVFLDQLARYEDASPDEEARQACIGLTSEYRLLYVVHVVREGDVLRLISARLAERAERRRYEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR7</accession>
    <name>E8WXR7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2738</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2738"/>
    <dbReference type="EnsemblBacteria" id="ADW69762">
        <property type="protein sequence ID" value="ADW69762"/>
        <property type="gene ID" value="AciX9_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2738"/>
    <dbReference type="eggNOG" id="ENOG50334P1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655358_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="49723" checksum="94F583CC3123C10F" modified="2011-04-05" version="1">MRIFLRSLKDQPAGPWMIAVILMLFAVLSFAEYRDYDGDDLGSSYVGCRLVAAGQVSHLYAHDPKDFAAIGPDKPWQDAADSGEFTAFLHPYVQTPLWAWVLQPLCTGTEFQTFQEIFTVLTMLSFVGCLWLTARFWAPSMFNSYAMALVVTCLWFSEPFGYAMALMQTHMLLLVMTIAALILAERERPVAAGLLLACATAVKVTPGMLLIYWLLTRRFRAAASMVAWSAVLVVITLLTTGPQVFATYLACLHRVSRVLLLSMNNQSFVAWFMEGGYNVREIYGFRILGLPDSVRIGSTALMVGFTVLGGVIDRRNAARGLSAAPLGAMIALMAATIFAPIAWTHYFVLLMVPLMVIVEENQRLTAAWSRWCVAGFALLIVALNFQPLATDIQNSMVGSFSLIRSEFYAGGLCIALLGVLAWCRRAREQVRSVADEEAKDEAAERPMQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS3</accession>
    <name>E8WXS3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2744</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2744"/>
    <dbReference type="EnsemblBacteria" id="ADW69768">
        <property type="protein sequence ID" value="ADW69768"/>
        <property type="gene ID" value="AciX9_2744"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2744"/>
    <dbReference type="HOGENOM" id="CLU_3356475_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="36" mass="3883" checksum="B6B30BD2F56A8767" modified="2011-04-05" version="1">MPDIAIAASFILIILIPCLVAMTSVEKSEPAPTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ2</accession>
    <name>E8WXZ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0459</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578859.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0459"/>
    <dbReference type="EnsemblBacteria" id="ADW67531">
        <property type="protein sequence ID" value="ADW67531"/>
        <property type="gene ID" value="AciX9_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0459"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_0"/>
    <dbReference type="OMA" id="RFCCAFQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="183"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="325"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="583" mass="64874" checksum="BE5193DA1B635425" modified="2011-04-05" version="1">MAEQDNTFRMHLSGPGPLDVTHFSGTRRDALPGADFLFEENPLAMFVYDKASLRLVATNARALDQYGYTREEFLALSLNQLLNDPAPIVHDPSAENLLASSERVERHRTKSGGSLTVEVRERQALAEGRTLCLVVAMDITENKKEQARWQTIAMQDSLTGLANRISLEERARQALITARRNGHRVAILCIDLDRFKQINDWYGHSIGDECLKELGSRLTRRLRGMDVVARVGGEEFTVVLAEVESAQSAMIVANFLLQAIGKVFEVENHTLTMGASIGVAVYPDHGTESDELQRLADLAMYRAKRAGGNRAFIAQESTDPYVDDGSHMEACIRTALAEETFQLHYQLEYRPNGTVRGMEALLRLPRQGGGFIEPDRFIPVAEESGLIYPIGYWVLAQACRQLKMWNTPGREPMRIAVNVSPLQLLRPDYAVSVMNVVQEWGIEPSWLELEITERVVVNFDEVAKGMRLLHSQGIRFAIDDFGTGYSSLQHLNRLPISTVKIDRSFVNRICDANGSYPIVEAIVAMGHSLKMEVIAEGVEKREQRAALERIGVDGMQGHLLARPASIDEIEAILGLSAHPDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY70</accession>
    <name>E8WY70_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1645</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1645"/>
    <dbReference type="EnsemblBacteria" id="ADW68697">
        <property type="protein sequence ID" value="ADW68697"/>
        <property type="gene ID" value="AciX9_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1645"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131462_2_0_0"/>
    <dbReference type="OMA" id="MQALNYI"/>
    <dbReference type="OrthoDB" id="1919090at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="13919" checksum="B6ACED7718F72D1B" modified="2011-04-05" version="1">MHHATSPLITWTCIAFVAALAIAGEVLIAAAMRNIGDLDLIRAHSGIPGAARKVLANPTFLAGAFCMALNFFAMLYTLSKVDLSLAAPGIASFNYVGNAIAARLFLKEDVDRRRWLAVLFVAVGVYLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY74</accession>
    <name>E8WY74_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1649</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580020.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1649"/>
    <dbReference type="EnsemblBacteria" id="ADW68701">
        <property type="protein sequence ID" value="ADW68701"/>
        <property type="gene ID" value="AciX9_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1649"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_5_0"/>
    <dbReference type="OMA" id="YTEITDG"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="54"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="44185" checksum="2968E7399C09BFAC" modified="2011-04-05" version="1">MANSGQTRSTTILLWIGGLVGAILIIFGIRALTREKIPVRVTTASLQPLISTVPTTGKVEPIHEYQAHAPGPGVIQKIYVEVNQHIKAGTLLMRMNDADAIARLASAQSTLSGAQLNQQVIGSGGTLEERTHFNQDIAAAQTEQRNAQNDLATEQKLQQQGAASAGEVLRAQQRLQTANTALANAQSHTASRFDSGDQRGAAARLNDAKNNLTAAQAGVAAVDIRSPIDGTVYSIPFSAYDFVPSGADDLLDVADLTKLQVRAYFDEPVIGQLAQGQPVKIVWDARPNVAWHGHILRAPTTVSSYGTRSVGEAIITVDDAKGDLLPNVNVTVTVTVSELPDALSIPREALHTEGANNYVYRIVNGHLTQTPVKVGAVNLTRVQITSGLDKNETVVLGPVMSSQELVDGLQVIQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY81</accession>
    <name>E8WY81_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1657</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580027.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1657"/>
    <dbReference type="EnsemblBacteria" id="ADW68708">
        <property type="protein sequence ID" value="ADW68708"/>
        <property type="gene ID" value="AciX9_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1657"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_0"/>
    <dbReference type="OMA" id="WRHPDEP"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018054">
        <property type="entry name" value="Chromogranin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00422">
        <property type="entry name" value="GRANINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="31927" checksum="C822BE51A6A780CE" modified="2011-04-05" version="1">MDTLIVPERTLNDALTLPEVGFGTYQLNGNEGVKTMVGAIRNGYRLLDSAFNYENEGAVGEAIRQAGIPRSELRVTSKLPGRHQKYREALRTVEESLFRAQLEYFDLYLIHWPNPKQGLYVEAWQALLEVKKRGLVRSVGVCNFLPEHLDRLEQETHVLPSVNQIEMHPYFSQPTQVAYDRAHGIATEAWSPLGRANDLLKNEVVTKIAAKLKRSPGQIVLRWHHQLGVIPIPKASSDERQRENLSLFDFELDVTAMDQIGSLNRPNGRLANQDPAEYEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY84</accession>
    <name>E8WY84_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1661</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580030.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1661"/>
    <dbReference type="EnsemblBacteria" id="ADW68711">
        <property type="protein sequence ID" value="ADW68711"/>
        <property type="gene ID" value="AciX9_1661"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1661"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_0"/>
    <dbReference type="OMA" id="MTRTGMF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="25236" checksum="99F81748ADE3354E" modified="2011-04-05" version="1">MIRGPLLGEFMGTFIMMLLGDGVVAGVLLKRTKAEGSGWMAITTAWGFAVLCGIFTANLFGSPDAHLNPAITLALAVQTGSFARFLPYLLAQVSGAFVAAVVVWLFYLPHWKITEDQSAKLGVFCTAPAIRSYGSNLFSEIVATFVLVLVVGSISSKLVLSTGAAAGLSPFLVGCLVWALGLSLGATTGYAINPARDFGPRLAHAVLPIAGKGHSDWAYSWVPVLGPLLGASLAGGVLRLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR7</accession>
    <name>E8WYR7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1705</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580072.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1705"/>
    <dbReference type="EnsemblBacteria" id="ADW68753">
        <property type="protein sequence ID" value="ADW68753"/>
        <property type="gene ID" value="AciX9_1705"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1705"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="LDYAMPG"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="123" mass="13035" checksum="9DACA2921D4CC574" modified="2011-04-05" version="1">MPAGEHLILCVDDEMVGLEVRRILLERAGYRVLTAGDGSKGLELFASEPVEAVVLDYAMPGMNGAEVARSMRITKPNIPILMLSAYTVLPAEVTRIVDLAMTKGEGAPALLEKLGSLLPASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT7</accession>
    <name>E8WYT7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1725</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580092.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1725"/>
    <dbReference type="EnsemblBacteria" id="ADW68773">
        <property type="protein sequence ID" value="ADW68773"/>
        <property type="gene ID" value="AciX9_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1725"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_0_2_0"/>
    <dbReference type="OMA" id="IANINFD"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="241"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="463" mass="48451" checksum="04D50DDB7E4B624A" modified="2011-04-05" version="1">MRLDRLAVGLMVGLMVAPVFGQAAWTVKPEWVRAHEEFLASDVMAGRGSATRDEEITATYVASEFMGYGLKMAPGMSSYLQAAEVVSPRLDGHAVLKAGGVTLNEGSDFTLLISSGADVSGPVAMVSGDLKTARVSKGAVVVVGALPAGQAGMQAIGAVQRSGPAMVVVGEDESTQGLYTMFGGKTRTPIRLKDAAAGRTRATIVSVSKAGMAKLAGLGSGTVLSLHVHVVPEATARKTFNAIGYLEGSEPGSGTILLTAHLDHLGIGAPVNGDSIYNGANDDAAGTTAVLELAHALAGGPKTRRNVLFVCYGSEEAGELGSTYFGEHPPVPLKELVANLEFEMIGTQDPKMPKGVLLLTGWERSNLGPTLKEHGALLGPDPYPEEHFFERSDNYALALQGVVAHTAAGWGTPPTYHKPDDDLAHLDIGFMTSAIQSLVEPVRWLATSDFKPAWNAGGEPKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA6</accession>
    <name>E8WZA6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GBBH-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0637</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579036.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0637"/>
    <dbReference type="EnsemblBacteria" id="ADW67708">
        <property type="protein sequence ID" value="ADW67708"/>
        <property type="gene ID" value="AciX9_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0637"/>
    <dbReference type="eggNOG" id="COG3536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117841_2_1_0"/>
    <dbReference type="OMA" id="PCATCHE"/>
    <dbReference type="OrthoDB" id="2003927at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="3">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="146" mass="16267" checksum="3BE63D184A66AF10" modified="2011-04-05" version="1">MSHEGIRIVSEETARRESAAEQRLPAEVVTPLKVRVMKSEGTGVAIEWKDGHHSAWNFAWLRAGCPCATCNEERNASGRKPGEVKPSAPTGPLVLYQAPPRPVDVTPVGKYAIRFKWNDGHESGIYSWDYLRRVCQCDDCRNSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB5</accession>
    <name>E8WZB5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0646</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0646"/>
    <dbReference type="EnsemblBacteria" id="ADW67717">
        <property type="protein sequence ID" value="ADW67717"/>
        <property type="gene ID" value="AciX9_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0646"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_1_1_0"/>
    <dbReference type="OMA" id="DEYVSRD"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234193" evidence="2">
        <location>
            <begin position="46"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="49757" checksum="06AC6EAC12117CD0" modified="2011-04-05" version="1">MPFPSPRIQTTPIIVYPETSMKTHKPLAPTLALLACLAAAAAVHAAPAQTPTPPAAPHSTVIDLPGTPNSRHAQKQHYVVLVSLDGFRYDYPTKWSTTHIAALARAGATAPEGMTPSYPSITFPNHITLVTGLLPEHHGIINNRFYDPTRKESYSYKEAKTNTDGTWYTGTPLWSLAEQQHMRAASFFWPGSEALIAGERPDDYVPFEDKFPDEARLDQIITWLRLPPAQRPHLITLYYSNTDHAGHDFGPNSPEVEAQVHHVDSLMGTLREKLDATGLPVDLIIVADHGMTTVEGTWITLDQFADLTNFKTDGWLLYPNSEADAAAAYASFRAHPDPRFTVYRRADVPAYLHYTDSPREGDPVIVPNGPYVFRAHVNTSKLPTGDHGYDVTRMPEMKALFVANGPDIRPGTQLPTFPNVDIYDFISKLLNLKAAKNDGTLTPLKPALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF5</accession>
    <name>E8WZF5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1795</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580162.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1795"/>
    <dbReference type="EnsemblBacteria" id="ADW68843">
        <property type="protein sequence ID" value="ADW68843"/>
        <property type="gene ID" value="AciX9_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1795"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_0"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="12360" checksum="AE609E1DC6526E07" modified="2011-04-05" version="1">MAGQFVSEVNDSNFEQDVLKSSQPVLVDFWAAWCGPCRALAPVVDQVAEQFNGQLKVMKMDVDKNSATPSRYGIRGIPALLIFKDGKVAEQIVGVVPKASIEQSITKVIGAPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI0</accession>
    <name>E8WZI0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580187.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1821"/>
    <dbReference type="EnsemblBacteria" id="ADW68868">
        <property type="protein sequence ID" value="ADW68868"/>
        <property type="gene ID" value="AciX9_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1821"/>
    <dbReference type="eggNOG" id="ENOG502ZP2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1666936_0_0_0"/>
    <dbReference type="OMA" id="HIVTESH"/>
    <dbReference type="OrthoDB" id="1789305at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022061">
        <property type="entry name" value="DUF3617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12276">
        <property type="entry name" value="DUF3617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234007" evidence="2">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17016" checksum="F085454601882FEB" modified="2011-04-05" version="1">MRFFLTMAALTALCSAAPAQEAPMKMGLWETTSVITMQLPPGMPSMMGGTRTITVQSCLTPESWQKTMERAQNPRKDCTYTDKTVTATGMTFAMTCTGRSTTMVKGETVFESKEKGSSTVHMEMSTSGSGGGKMVTDSKGTTRYLGADCGKVKPYTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR1</accession>
    <name>E8WZR1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3014</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70035">
        <property type="protein sequence ID" value="ADW70035"/>
        <property type="gene ID" value="AciX9_3014"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3014"/>
    <dbReference type="eggNOG" id="ENOG50330SU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577175_0_0_0"/>
    <dbReference type="OMA" id="VRLEMRQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="473" mass="50693" checksum="2423F1CCE033BE85" modified="2011-04-05" version="1">MGFHKSPTNSETITTLFKPLQLAALAFAFQAIPAPHPHPIHFAYQRPVTLPAGQTSRTCVTLDAPVFAHSNATLSDLRLYTGSAEVPYATTISESSLEPPESARILNLGERSGRITFDLQMPPRSYTQVVLDLTGANFLATAHVTGLHSADDKSGTTLGAFTLFDLTAQHLSRNTTIPLQESSFPYLHIDLAVTPAPASPPQTFSPTMVQGAQIPPTRDAQTLYTAVAETSAFTQQETPQLGRATVADITIPARIPVERITFTLAPGSKLNFSRPVRITATPQKEGVILSAAKNLSSSLEAPDPASGAPETITGEITQVRLIANGPEIHQERLSIPATLGANLHAPAHIQIAIQNGDDKPLPVAAVRLEMRQRKLCFDPPAGAAGGKAEPVTLAYGDPALTPPIYDYARLFNPAAPTRPAILGPEQPNPNYIPRPQQLRPFTERHPELLWVALLAVVAVLGVIAFRSARTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS7</accession>
    <name>E8WZS7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579066.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0668"/>
    <dbReference type="EnsemblBacteria" id="ADW67738">
        <property type="protein sequence ID" value="ADW67738"/>
        <property type="gene ID" value="AciX9_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0668"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_0_1_0"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="31190" checksum="4E625D2770E4C0DE" modified="2011-04-05" version="1">MIESVAIVGTGLIGTSIGLALRRAGFDGEIVGVDAKGDEAAMAVSMGACDRVGAFDDVWKCDVVVLAVPVLTILDFLGRLAPLMGPDQLITDVGSTKLQIFEMVRSLRGNEVRVRMLPGHPMAGKESGGAELGDAGLFEGAMWLFTPAEEEWDVEREWREWVTRFGARTMDMDARRHDQVCAWVSHLPQMVATAMAAMYEDEFGAEPEIAAEFQAIGGRALREMTRLGASPYSMWRDVAMSNTEPLAATLFALEQRLQHLREGLRTPELREEFRLANAFRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT2</accession>
    <name>E8WZT2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0673</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579071.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0673"/>
    <dbReference type="EnsemblBacteria" id="ADW67743">
        <property type="protein sequence ID" value="ADW67743"/>
        <property type="gene ID" value="AciX9_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0673"/>
    <dbReference type="eggNOG" id="ENOG50330EI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545459_0_0_0"/>
    <dbReference type="OMA" id="NFERAEY"/>
    <dbReference type="OrthoDB" id="2100525at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="19064" checksum="43F378706D7D93BD" modified="2011-04-05" version="1">MDLNTPNFERAEYREPQVIEGYPVEPAGGRGLGPALLFGLGAAVVGCVGYAVVGLSHIMASIVSIGVGWLVGKAMMTGSGGVGGRPYQVAAVLMTYFACSVGDMVDILHFQGIPFALMGKLPPAFLLKLAVGLPFLQLRSNPLNGGLGLLILFFGLQAAWRIAAGGPGFGRVGGGPRMTPFGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV8</accession>
    <name>E8WZV8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">AciX9_0699</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579097.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0699"/>
    <dbReference type="EnsemblBacteria" id="ADW67769">
        <property type="protein sequence ID" value="ADW67769"/>
        <property type="gene ID" value="AciX9_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0699"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_0"/>
    <dbReference type="OMA" id="CAYTNTG"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230502" description="Aminopeptidase N" evidence="13">
        <location>
            <begin position="26"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="16">
        <location>
            <begin position="108"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="14">
        <location>
            <begin position="257"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="15">
        <location>
            <begin position="558"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW67769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="887" mass="98486" checksum="04B8BD600DAED0CF" modified="2011-04-05" version="1">MFAGSPVFRASRLLLALLAISSPLAAQSLPEAGISRALASARAARLSDLHYKLSYELHPHAEVTQAHETLTFTDTGTGDLPLDYRDGTLTSASLNGTTIPTQLVNGHIILPAAALHKDQNTLTIAFQSNIAAAGKAITRYTDRDDKTEYLYTLFVPMDASMAFPCFDQPDLKARFTLDISAPTDWTVIGNTAATSKTARGDSAQSIFPETRPISTYLFAFAAGPFEAIQGNPGEPTIYVRKSQLTRAKAEAPQVQQITARGVAYLSDYFAQPFPFPKYDLVLIPGFPFGGMEHAGDTFLNEDGVLFRTAPTASDYFRRDILVLHETTHQWFGDLVTMRWFDDLWLKEGFAQYMAYKAMAQLKPDTNPWKHFYEEIKPLAYAIDETQGTTPIYQNIPNLKDAKSAYGAIVYQKAPAVLKQLDYFLGDQNFRDGLRLYLKQHAYANAQWADLIGAFQATGKSDVQAWASAWILQRGMPEVTVEFSCRGDRLGNIHLMQHDVLETDAVWPISNQIFLSFPAKPASAKPFDLPVYEMEPIRVDWNRPAINVISNHAACPTSIFANYGDQAYGRFLLDPISEKAVTASLIALSTTPTDPLLKSQLWGALWDQVHTAQASPRAYAELALKDLPTEQDESIARILGGRISAAMHAYLSDKGREALAPQAESVTADRMIHAPTLGLRIVNYRTFTSIAQTPTALAQIKDLLSGKLTIEGMPLKPLDRWNLIGTLIQQNDPEAPALLAAEKQRDQSGEGQKYAYAQQAATPTEATKQQYFADYLRTSSQPGGPPAVQEDWLTQSLGRFNSWNQTPLTEPYLTRALDALPDIKRNRKIFFLGAWLGSFIGGQHSPEAQQIFHAWLTRKDIDPDLRLKVLELSDELDRTVLIRQKFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW5</accession>
    <name>E8WZW5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0706</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579104.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0706"/>
    <dbReference type="EnsemblBacteria" id="ADW67776">
        <property type="protein sequence ID" value="ADW67776"/>
        <property type="gene ID" value="AciX9_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0706"/>
    <dbReference type="eggNOG" id="COG3240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470724_0_0_0"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008265">
        <property type="entry name" value="Lipase_GDSL_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01098">
        <property type="entry name" value="LIPASE_GDSL_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234022" evidence="2">
        <location>
            <begin position="23"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="3">
        <location>
            <begin position="326"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="579" mass="57939" checksum="5961E55A16F1E040" modified="2011-04-05" version="1">MSALRHALTVALLVFSAVLLHAQAYTSIVVIGDSLSDTGNDAHVSTALYTAAAAVPTPATGYTQGSFTDGADTAPAAQLYSGVWIKQLAAMLAAKPPVLNSLDGGANYAYGFAFTGSGTTPFAYGPGNVFTFPVNNMGLQLSTYLATNPTITSKTLFVVWGGANDILNATSSAAVTTAAANEAAVIQALIAAGATDFIIPNLPPLGAVPRLNTTASAASATAAAAGFNQALAAYVAALPAANPGKSLHLYSLDVFTLFNTIIAAPSTYGFANVTISSNFLAVNPDTYLFWDGLHPTTAGHHQLALAAAALIAPGATTTTLASSNLSANLNASVTLTATVKSPAGIPTGVVTFFDGTTAIGNGQLNTAGVATYTTSSLTAGTHNITAAYVASQYFNASTSTALSEVVTAPAISLTATPVGLTIASGSTGSEALTVATVGGLSGTVSLSCAPLPSPLTCTFSPATLTFAGANNTLTSTLTVNTAGVNISQLNRTRPGSNTLQAIAACSLLPFFGVLVFRRRHLRSLPLLCLLLLFSSGAVLGLSGCSGSSSANAPKGLYTIPVTATGGSATSSLSFVVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY3</accession>
    <name>E8WZY3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1832</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1832"/>
    <dbReference type="EnsemblBacteria" id="ADW68879">
        <property type="protein sequence ID" value="ADW68879"/>
        <property type="gene ID" value="AciX9_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1832"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022186_0_0_0"/>
    <dbReference type="OMA" id="ANPAGHY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="29665" checksum="9B14FFD876D439D4" modified="2011-04-05" version="1">MEHYETVLAIDPHSPPARKGELSAATALALESRHAGNQQAALLCLSHARNYLPDDPTLLHHLGIQLYDMHQLAAAAEALAQAIALAPHDPDNVYALARVEQDQQSFPAAERHYDTYLAARPADASAHYGLGHLLQMEQRPEEADAQFNESIRLQPLQTESYYQLGQMALDDHRDEAAKPLFERTLARAPNHGGALAGLGILAYRQMDYSTAVASLRKATIAAPDYQVAHYYLGLALARLNDKEASAQELKIAADLAIKQQGKSAPISSQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X012</accession>
    <name>E8X012_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1862</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580227.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1862"/>
    <dbReference type="EnsemblBacteria" id="ADW68908">
        <property type="protein sequence ID" value="ADW68908"/>
        <property type="gene ID" value="AciX9_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1862"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_0_1_0"/>
    <dbReference type="OMA" id="YGDFSYG"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="40298" checksum="51D205BA020C1CBB" modified="2011-04-05" version="1">MNSIWNQRENNFDFLRLALAVLVIYSHSFPLGLSSDAQEPIFRWTNGQMTGGSIAVDLFFIMSGFLITASAERSGSVFSFLKKRVLRIYPAFVVASLLSAVVVVPMAAAHFAYNSPIARVGDFLLQTLRLVEFHYNSAFLTNPYPGAINGSTWSVSFEFWCYIGVALLLVSTLLRRRILLLAAFLTSVLVSVLFQLKGWIFGGKLLGLILGSPQLWARLLPLYLAGVVFYLFRDRIRLSHTLAIVSGLALVAACWTPIGWTALFPFAGTYLVFYLAFTPWLRLHRFGRFGDFSYGTYLYAFPITQLLMKHFAHPIAPWLLFVCATPLTLIAAATSWYGVERHFLQPARRKETIAHAIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X048</accession>
    <name>E8X048_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argR</name>
        <name evidence="10" type="ordered locus">AciX9_1898</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580263.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1898"/>
    <dbReference type="EnsemblBacteria" id="ADW68944">
        <property type="protein sequence ID" value="ADW68944"/>
        <property type="gene ID" value="AciX9_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1898"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097103_3_0_0"/>
    <dbReference type="OMA" id="IMGTICG"/>
    <dbReference type="OrthoDB" id="1640037at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="9">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="146" mass="15791" checksum="D5DD959AFB1E7020" modified="2011-04-05" version="1">MKQQRHNAIRQILDRTAIANQDDLRRALAAQGHNVTQATLSRDVRELKLSKGPNGYSIASNAAEDADEGPGIREVMKGFGLEVRQALNQLVVIAVTGGAQPIAAGVDYEDWPEVVGTIAGDDTVLIICPDDKQAKTLKKRIESYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X061</accession>
    <name>E8X061_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3021</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581356.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3021"/>
    <dbReference type="EnsemblBacteria" id="ADW70042">
        <property type="protein sequence ID" value="ADW70042"/>
        <property type="gene ID" value="AciX9_3021"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3021"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_0_0_0"/>
    <dbReference type="OMA" id="DATKHML"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230510" evidence="1">
        <location>
            <begin position="23"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="442" mass="48128" checksum="CE69E48756DF3FAB" modified="2011-04-05" version="1">MRTPIALLLLAFALPPTSPAQKHSNSHRPKVVIISLDAFPAETLHDPFIAAPTLHRLMKAGAYARSMQPINPTVTWPNHTSLITGQDASHHHVLVNGLIVDQRTEKDARIDAQASKDQLVAVPTLYDLAHKAGMTTAEVDWVAIMHAPTIDWSFAEKPNPDGIIERELIAAGTATREELAKFNTPRQAWRDRLYTAAAVDILRKHHPDLLMLHLLALDSIEHHTGFGTDADYNTIAFLDDRVKDIMEAVQANGDTARTTFIIVSDHGQASVHKHLHPSFLLGDADLESPSSPTPTSIIEEDGYALLYQKNSTPASLADLKKLFAGKPGVSAVLPPDEAARLGWPTPAQTTQAPDLLLYAADDYSFTEERSDAFVTDSEQRGVHGYPNTNPLMQAIFIAQGAAIQPRGEFPAISNLDVAPTVAHILGLTLPDAQGKPILEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C8</accession>
    <name>E8X0C8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvPB</name>
        <name evidence="5" type="ordered locus">AciX9_3089</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581423.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3089"/>
    <dbReference type="EnsemblBacteria" id="ADW70109">
        <property type="protein sequence ID" value="ADW70109"/>
        <property type="gene ID" value="AciX9_3089"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3089"/>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_0"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="515" mass="56323" checksum="1274E025F77EF39A" modified="2011-04-05" version="1">MSDTKFVGTPRKVTTHVNQNEGLIFEKSSPGKKAYRLAELDVPAIDAKKLLGPALRTDLGVMPELSEIEIIRHFTRLSTWNYAIDLGMYPLGSCTMKYNGRVNEAVARLEGIAEAHPYQPESLSQGCLQIMKTLEEALLEITGMDAITLQPAAGAHGEFTGILMVRAYHESKGNARKKIIVPDSAHGTNPATAAVVGYEVANLKSNAQGMVDLEELERMVDEDTAALMLTNPSTIGVFESDIHKIADILHAKGALLYMDGANMNALVGKTRPGDFGVDVMHLNLHKTFSTPHGGGGPGSGPVAVKKILEPFLPKPTVETKPDGSLTLQFDRPQSVGRVRMFYGNFGMFVRALAYILANGPDGLRQTTEDAVLNANYIRAKLLDTFELPFKRPSLHEVVFSDKLQAKNGVKTGDMGKRLIDYGFHAYTVSFPLVVSGAMMIEPTESESREELDLLIDALKQIAQEAAENPELVKTAPHTTRLQRLDETTAARKPILRWKAPVAKEPVQPDTAAKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K1</accession>
    <name>E8X0K1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1906</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580271.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1906"/>
    <dbReference type="EnsemblBacteria" id="ADW68952">
        <property type="protein sequence ID" value="ADW68952"/>
        <property type="gene ID" value="AciX9_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1906"/>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="28596" checksum="C32568353DC1E293" modified="2011-04-05" version="1">MSTFLDLQHVNVVRGGRTVLHDINLQVAKGEQIAILGPNGCGKSTLIKTITCELYPLAQEQTRIAIFGRPRWDLTELKRRLGVVSADLPGKPTLSITGYEAILTGFFSSSTLWPNLVATEVMRERAEEVLIQVDAVRLRDVLFGEMSAGQQRRVMIGRALAGSAECLLLDEPSNALDLLAQRDLRNLIVSLADQGTTMLHITHHIADIIPAMKRVICMKEGRIVADGPREDLLTEANLQWLFGTEVSLSERDGFFHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S2</accession>
    <name>E8X0S2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1977</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580342.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1977"/>
    <dbReference type="EnsemblBacteria" id="ADW69023">
        <property type="protein sequence ID" value="ADW69023"/>
        <property type="gene ID" value="AciX9_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1977"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314441_0_0_0"/>
    <dbReference type="OMA" id="HYDTGTA"/>
    <dbReference type="OrthoDB" id="1220211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="963" mass="101359" checksum="A960FFB606833CCE" modified="2011-04-05" version="1">MSKVIMGVAEIGAAAGLVVAANFVPGGQALLTPFVLHLVEGLALSGASMLAGAAASALTSNRGMTITTRQPASNRQIIYGTQRVGGVEIYRSTTGSSLDQFNYVIVLAGHVCDSIVNLYLDGRQVHWEVGSTGNSTRNGVNFGGHCDGNTYTGPNGEQYNFGGGHGGYHVYCEARYGDQLAGDVIGGLTANDANWAASSEGSPYVGDCCYVFLKLESDPNVFPGDPEIRFTVNGKQVYDPRTGTTAFSTNRALIIADVISDLQFGLGDNTVNQAQLVVAANVCDEQVALAGGGTESRDCCNYHYDTGTAPGDVLVTMVEETLGRLSQIGGEWFYWPRYWQGPSFTLDENALTGPISWNPYRSAPDLINRCTGTYVAPQYPFNIAGNLYDANGFDPATGTIQNNFQYGFQPTNFPQFAADVPHGYASDEYLNEDGGIIRPKEITLRTVLSVAQAQRIAKGTLLDNRRQGTGSFPMSLAAWRMQPVDVMQFTFPEYGWTEKLLEVTDVVFAVTENDGDQNTPGVPSIGVVVSVRETAASDYEDLGPGEEQTIYDAPVLAQTTYVPAPPTGLVLTSGAATALQTLDGVVHPRIEVQWTTPQDILTNQIQVQYSTVANPTLWLDAGLVDVSNNLTYISNVIAGAGYNVRIRGLRANGAQSPWEEIDGYTVSITLSVQGILALAPGSLVADAYSDSTGQYAEVTVQGFTAMVGNASVAVLPNGTTVLLQGLAQQQLYYIYYVDLNFTGGAITPIDTQNTADFLNKPGYFLIDSIITPYAPPASGSGGGGGGTATGTRYSPSNFQDTGTRTTTSPTSAYDGDTSTAATVSGSYTYVAGGGGEITQNASGPSAQGSLPPGGGSSSRSSFGLCLWEDFPSVTTTTATNLNLVAAYRVLGTGSPQVTVTGNIGSTANIVMTESATTASATYTMAIPLGTDLSTVSLEVNVTADDNGSTSNTGSFSVYEIYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S6</accession>
    <name>E8X0S6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EmrB/QacA family drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1981</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580346.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69027">
        <property type="protein sequence ID" value="ADW69027"/>
        <property type="gene ID" value="AciX9_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1981"/>
    <dbReference type="HOGENOM" id="CLU_2206319_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="11426" checksum="BA73F0F7881B0D0E" modified="2011-04-05" version="1">MKNRKVLVVFLVVQFVGITCLALWPHAPSAMGIPMWGTALILLCPGNFLGGWLIQSLLWRGPLGLVALGLLSALTAVVINGIIWFAIVKLFRLVFNRGSKGAGVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S8</accession>
    <name>E8X0S8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3092</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70112">
        <property type="protein sequence ID" value="ADW70112"/>
        <property type="gene ID" value="AciX9_3092"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3092"/>
    <dbReference type="HOGENOM" id="CLU_1935082_0_0_0"/>
    <dbReference type="OMA" id="DPTDHAS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14858" checksum="94EB6E74EC73E1CF" modified="2011-04-05" version="1">MAFVNDTEFQDDFRKVGQDVTAGFERPGAPADPTDHASSENLDVAPKTDDLDEDDDLEDDDLDEDDEDEDDEDLEDDDLEDEDDEEDEDDFEDDEDEDDEEEDEDNDELEEDDDTVKTRAGDAVKVARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W1</accession>
    <name>E8X0W1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3132</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581459.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3132"/>
    <dbReference type="EnsemblBacteria" id="ADW70145">
        <property type="protein sequence ID" value="ADW70145"/>
        <property type="gene ID" value="AciX9_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3132"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021588_0_1_0"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="483" mass="52001" checksum="19827EB14E0682DF" modified="2011-04-05" version="1">MPGKQSKAKRSHLSGELSAFSSLLEHLQLAHHFKGDATMVGDDPIIRSPHKLGEASATAQLLIGAAGAAIWAAKTGQSTDIEIGVFDALHFLHPTHYVSQAGHPINVGAEFVETNGIFQCKDGRHVMIEAGPPYPKLLKGYLDFFDCGNNKKSIAREIDKWNAKDLEDALAVAGLPCCRAFGREEWLKTEQGALLSKVPVIEIEKIADGDPIPFSGAASPLENIQVLDFTHVLAGPRSTRSLAEYGAEVLHVSAPAYPDTLAQHLGVDVGKRCAYLDLRNPDELATMHRLASQADVFATTYRNAVNRKFGLTPQELASRSERGIVCMTANAYGHSGPWTDRPGFDQNGQVASGFAVREGGDGPPRFSPVFYLADLMTGYFAAAGTMAALLRRSIEGGSYNVKLSLSRSAMWVQELGLLPLDEQANVPSEDKHPPTLTTIDTVYGPLSFLASPIRFSNLSLPSAFQLEPYGASAPAWLRGVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X186</accession>
    <name>E8X186_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1995</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1995"/>
    <dbReference type="EnsemblBacteria" id="ADW69040">
        <property type="protein sequence ID" value="ADW69040"/>
        <property type="gene ID" value="AciX9_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1995"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_10_0_0"/>
    <dbReference type="OMA" id="STYMGHA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="34069" checksum="9D05AE7D217CA452" modified="2011-04-05" version="1">MLLQLCQYLGPVALAAVTAKDVLGFLDGQSIGSRTWRLKHQMLSRFFEFWSARAVLPGLRMPPQRPEVRQTFEPYIYSRAEIQSLLRAARTDHHPTRLVDPQTLRTFILFLYGTGALTGEILGVKDADVDLETGMLTIVSARWNRSRSIPLSRDLCEVLQKYRNWRARKRLFDPHFLVTKNDKPLSKKSVVVCFARLRRIAGVCRRDGSALEPRLNDLKFTFAVHRITSWIRNGANLSRMLPALAAYMGQVDLGATERYLSMTPERFRKELNRLSPRKGKAHWRDKPELMKFVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A0</accession>
    <name>E8X1A0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2009</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69054">
        <property type="protein sequence ID" value="ADW69054"/>
        <property type="gene ID" value="AciX9_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2009"/>
    <dbReference type="eggNOG" id="ENOG502ZUTD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2617042_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="9147" checksum="8886C3FF87F93515" modified="2011-04-05" version="1">MHFMSTAKGWHCQFLEEDLKTPLRRRLTFQDPSKIEEMAEKGGAVRTSEGTQIMEYALKQGRGSVWLNLTEEQYRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F2</accession>
    <name>E8X1F2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3176</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581499.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3176"/>
    <dbReference type="EnsemblBacteria" id="ADW70187">
        <property type="protein sequence ID" value="ADW70187"/>
        <property type="gene ID" value="AciX9_3176"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3176"/>
    <dbReference type="eggNOG" id="ENOG5033C87">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158535_0_0_0"/>
    <dbReference type="OMA" id="SEWCREV"/>
    <dbReference type="OrthoDB" id="1702091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14505" checksum="66A0876BFD4CB413" modified="2011-04-05" version="1">METETQGSHINLETRIRRSKGRTGRTISATAKVTRDEQNEMEAAAMQRGQSLSEWCREVLLAAARGETITPIFTEIVAIRQLLNSTLRNVACGEVMTPQAFQTELQGIRSSKHKAAVEVMQQYARTEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M8</accession>
    <name>E8X1M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0879</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0879"/>
    <dbReference type="EnsemblBacteria" id="ADW67947">
        <property type="protein sequence ID" value="ADW67947"/>
        <property type="gene ID" value="AciX9_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0879"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_28_1_0"/>
    <dbReference type="OMA" id="WYWVLVE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18720" checksum="05DB1AEA7F3FA157" modified="2011-04-05" version="1">MRSDDIVTDRLCLISITPESAGAEKAADGRLGEVTGADVAEGWPPENWEPHVFDWLLAQFAADAGCVGWNRYIALRDGDGGRTLIGTVGGFRKAESMSECEVGYSVVDEYQGLGYATEALEGLMAWIWEDETVASVCAQTFPALAGSVRVMEKCGMRLVGAGFEDGTVLYRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T2</accession>
    <name>E8X1T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DGQHR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0934</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0934"/>
    <dbReference type="EnsemblBacteria" id="ADW68001">
        <property type="protein sequence ID" value="ADW68001"/>
        <property type="gene ID" value="AciX9_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0934"/>
    <dbReference type="eggNOG" id="ENOG502Z7Y8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072752_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017601">
        <property type="entry name" value="DGQHR-contain_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017642">
        <property type="entry name" value="DNA_S_mod_DndB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14072">
        <property type="entry name" value="DndB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03187">
        <property type="entry name" value="DGQHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="36050" checksum="F6BF96D60C7B5095" modified="2011-04-05" version="1">MAPTRSSFQALPLTQNEHRFYFSTIPVDELFPYCFVARRQEDPSQGFQRTLSQDRANDIARYLSAGNGSIPTNVVLSAQPIASLKYIAGSKTLSFLQVERSFLVLDGQHRLWGYSKCTRKHRVPVAIYQGLTRAEEAKLFIDINTNQRGVPAALLLDIKQLADMESVKENIMRVLFDRLNTDGKSSLAGRLSPAKPSPSKISRVAFNRALGGALDSELVRGLEADPLFQLVRNYINAFDAELQDSQLLTRASYFEAMFDIFDEALRLTLGKKKNLKQASIQEIIRTIAKLDFTGQSMTRKEYLVSMQSSLRQSLAVSVDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U1</accession>
    <name>E8X1U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2057</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580419.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2057"/>
    <dbReference type="EnsemblBacteria" id="ADW69102">
        <property type="protein sequence ID" value="ADW69102"/>
        <property type="gene ID" value="AciX9_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2057"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097532_1_0_0"/>
    <dbReference type="OMA" id="YKQMKMY"/>
    <dbReference type="OrthoDB" id="1519412at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="23549" checksum="6ADE48224190A919" modified="2011-04-05" version="1">MHTPSSTPFVDAALITRMHDEATALWHTTLPDLAPDPASLLHQVRAHHRANYDLWHQEDEARNPSATDSIIATVKHAIDRLNQLRNDTVEQMDVRLLAEASPQNEDAPLHSETPGLIIDRLSILALKQYHTAEESQRPSATEQHRLRNLARLHVIRQQRNDLALCLDQLWNDIRSGRRRFKLYRQMKMYNDPDLNPVLYRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V5</accession>
    <name>E8X1V5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tagaturonate/fructuronate epimerase</fullName>
            <shortName evidence="1">D-TagA/D-FruA epimerase</shortName>
            <ecNumber evidence="1">5.1.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uxaE</name>
        <name evidence="2" type="ordered locus">AciX9_2071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>keto-D-tagaturonate = keto-D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:51656"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
            <dbReference type="ChEBI" id="CHEBI:59881"/>
            <dbReference type="EC" id="5.1.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580433.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2071"/>
    <dbReference type="EnsemblBacteria" id="ADW69116">
        <property type="protein sequence ID" value="ADW69116"/>
        <property type="gene ID" value="AciX9_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2071"/>
    <dbReference type="eggNOG" id="ENOG502Z82R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653555_0_0_0"/>
    <dbReference type="OMA" id="TIAPKFT"/>
    <dbReference type="OrthoDB" id="647950at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016856">
        <property type="term" value="F:racemase and epimerase activity, acting on hydroxy acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02243">
        <property type="entry name" value="UxaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032586">
        <property type="entry name" value="UxaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16257">
        <property type="entry name" value="UxaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="46061" checksum="AF57722A5623012A" modified="2011-04-05" version="1">MSDDLKLPRFSVGVGDRFAHQAKAQLQACIMAADAGVEVVPVWNKSNREHMIIGSEPSATRLAADAAVKELGWTKPYFLDADHINLKTVQRFLDPCDFFTLDVADLIGQPAKPEDVTQFIHNHPELVGEVVIPKITEPFKTDKAFVEGVANKFLAAVKHAGEIYRLLVENKGVGRFVPEVSMDETDYPQTPVELLIILAMISDEKIPIQTIAPKFTGRFNKGVDYVGDVAQFTKEFNEDLAAIAYAVHTYGLPDNLKLSVHSGSDKFSIYKPMYEAVKATGAGLHLKTAGTTWLEEIIGLAEAGGTGLEIAKEVYSEAYAHQAELCGPYATVINIDHAALPSPETVNGWTSDQFTGALRHDQSNPAYNQSLRQLLHVGFKVAAKMGDRYLKALEANEAIVAKNVTTNLFDRHIKPVFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z0</accession>
    <name>E8X1Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2107</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2107"/>
    <dbReference type="EnsemblBacteria" id="ADW69151">
        <property type="protein sequence ID" value="ADW69151"/>
        <property type="gene ID" value="AciX9_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2107"/>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062630_0_0_0"/>
    <dbReference type="OMA" id="GTMRPHG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="40780" checksum="2EBF54B4C1C912E4" modified="2011-04-05" version="1">MLVKGVNDMVEQVLTERTSRVERTDLRSIPFPAEFSEGAHNAVTTCLQIQADEKVTLITDRKCVTIAASMAVELDRLGCAWNAFVLEDVASRPLDGMPEVVLEDMESSQVSIFAVEVQPNELRSRMQMTDVVNRRRMRHAHMVNITPEIMTQGMRADFNAVDRLSQAVLDRVRKATYVRATTPAGTDLHAQMDPDYRWFKTSGIISPEKWGNLPGGECFTAPGEVNGVFVVDGVVGDFLCKEYGLLEDQPLTIHIEGNRITKVSSANKKLEKDFWAYTHTDKNSDRVGEFAIGTNIGVERVIGNILQDEKFPGVHIAFGDPYGAHTGAKWKSSTHIDVVGLRFNIWLGDAEGEHQIMRDGEFLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X237</accession>
    <name>E8X237_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M61 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3269</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581592.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3269"/>
    <dbReference type="EnsemblBacteria" id="ADW70280">
        <property type="protein sequence ID" value="ADW70280"/>
        <property type="gene ID" value="AciX9_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3269"/>
    <dbReference type="eggNOG" id="COG3975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435415_0_0_0"/>
    <dbReference type="OMA" id="EVYAWDL"/>
    <dbReference type="OrthoDB" id="679125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024191">
        <property type="entry name" value="Peptidase_M61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016493">
        <property type="entry name" value="Glycyl_aminpptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234286" evidence="1">
        <location>
            <begin position="21"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M61_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M61" evidence="2">
        <location>
            <begin position="304"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="626" mass="68220" checksum="E3AC31920E6D388B" modified="2011-04-05" version="1">MKVGIAAVSAFVMGAGLAWGQGAPITLSVDLRDAPKKILHATETIPVQPGAMTLAYPKWIPGEHMPSGPIDDQAGFLITGNGQPIRWERDPIDMFAYHLTVPAGVTSLTVKMDFLATPNGGSFTAGGSTSANLAVLSWNTLVVYPYSGPTMKASDVMIAPSVTLPEGWHYGTALEPTGGGNSAPGDQVGFKTVSLEQLIDSPVLTGRFFKEIPLAPEVTPKHYLDIVADGPEDLAINQAHIDDFSKLVRETGALYQSRHFTAYHFLVTLSDETLHFGLEHHQSSDDRIPPDTFTNDHTFVEAGDLLPHEFTHSWNGKYRRPAGLATPNYQVPMVGDGLWVYEGLTEYLGDVLAARCGIWTPEQFRDRLAEIAAKYDNRPGRTWRDLQDTARMAQVLYTVGGPYDNWRLGTDFYEEGELVWLDVDTTIRSKTNGRKTLNDFVAAFHGLGGNTGPKVVPYTFEDVVAGLNAVVPMDWAGFLNERLHMLQAAAPLGGITNGGYKLVYKDKMSAWSEASGGVDFWYSLGLHVSGKGQIRDVLVGGLGDKAGFGPGMTIVAVNGRAFSTPVLRAAIVDAKESQAPTEFIVENTGFYKVIKMDYHQGEKFPVFERVSGVPDRLDEILKPMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X247</accession>
    <name>E8X247_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3279</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581602.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3279"/>
    <dbReference type="EnsemblBacteria" id="ADW70290">
        <property type="protein sequence ID" value="ADW70290"/>
        <property type="gene ID" value="AciX9_3279"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3279"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_0"/>
    <dbReference type="OMA" id="CIREMGS"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234099" evidence="3">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="19407" checksum="9BEF614662E05A30" modified="2011-04-05" version="1">MHSPIQPAALALLAALCVPVTAEPIAHSLTFQDRTGHSHTFDELRGHPAVINFWATWCGPCKEEMPRLQKLSESYAPQNVAFIAISLDAPDTRSRIDSVIQKRNFHLPIWTGATDATLTELKLGVLVPATLILDSDGEIIGKIEGEASEKDIRSRLTWALNGHQGKQPNVIQKNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X272</accession>
    <name>E8X272_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ordered locus">AciX9_3304</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581627.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3304"/>
    <dbReference type="EnsemblBacteria" id="ADW70315">
        <property type="protein sequence ID" value="ADW70315"/>
        <property type="gene ID" value="AciX9_3304"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3304"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_0"/>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17514" checksum="EAD2D2DA19A3CE13" modified="2011-04-05" version="1">MAIEKATFGAGCFWGAEARFNELAGVLDTAVGYAGGGLEHPTYKEVCTDKTGHAEVVEVTFDPSRLSYEALLDAFFALHDPTQLNRQGPDWGKQYRSVVFANNDEQMAAAKAKIAELSASGSYRKPIVTTVEEAPMFWKAEEYHQRYLEKRGMVSCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X297</accession>
    <name>E8X297_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0962</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579353.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0962"/>
    <dbReference type="EnsemblBacteria" id="ADW68029">
        <property type="protein sequence ID" value="ADW68029"/>
        <property type="gene ID" value="AciX9_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0962"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OMA" id="VCPGLMR"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="36028" checksum="317BE1F6DD54CD11" modified="2011-04-05" version="1">MKKSTAFYATQIIATSLAAAAAYALIPSENRLRWGQVAIITGGSRGLGLAIAHRLGKAGLKLVLAARSEDDLELARDQILRSRDVTDEDDILLIACDLTDSNQCGALIDSAIRTFGRVDVLVNNAGIIEVGAVEDQTIEAYERAMATNFFAALYLCQAVLPHMLARKSGSIVNISSIGGKLAVPHMLPYSAAKFALTGFSQGLHAEVRSKGVRVTTVCPGLMRTGGEVHAQFVGDVEKEKQWFQTAATTPLLSVTSEYAANRIFSAVNAGRAEITISPQAWLMARTAGLMPETTQFVNSLVNEYVLPAAVKAAPEPAVLHVHHNESDDEISAADPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D4</accession>
    <name>E8X2D4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1000"/>
    <dbReference type="EnsemblBacteria" id="ADW68066">
        <property type="protein sequence ID" value="ADW68066"/>
        <property type="gene ID" value="AciX9_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1000"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017991_4_0_0"/>
    <dbReference type="OMA" id="CHLRDRP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="225"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="623" mass="70609" checksum="8941365FB69B6FFB" modified="2011-04-05" version="1">MTNGRGLRLSSGEEVYFEGRRCEIVAVLDLETAIVELRGDGGRIAVPVASLRSRPSTDGESHIKADLNQVSAEVWAIAETRLDAIRPLLDLPKRTKALVCSRAKELGISYGPLYVWIHRYESTMLLSSLLPLDRSGGRGRTRITPERESLLLETIQSHYLNKQKLTTQNVHRELKNRCFEAGLRPPSVQTVRNRIGRIDAALITKRRQGARAQRSFEPTIGSFPEVAGPYGVIQIDHTMLDVQLVDEQHRKSIGRAYITIAIDVFSRMVAGFYVSLDPTGDLSTGLCLVHAILPKKPWLERLGLDVSWSCHGLMDTIHTDNAKEFRGKTLARAAAEYGITLKRRPVRQPHYGGHIERLIGTTLKQLVHTLPGSTFSNVAEKGEYDSEGNACLTIAETERILTLWFTGSYHQTIHRGILMTPLEKYRLGRLGTEPGGKSAPRLPEDMDRLRIDFMPSIERCILSYGVVIDEVYYWGDILRPWINAPDPHDRKKKRLFLFKRDPRDVSVIQFLDPTTNTFHPISYRNITHPSMSLWELREARKRLKIHGKKTIDEHAIFQAHRSIQAEVKSAAEKTRSARRESARKAVQGNRESLPSPAADLVLAELQSKEFQYDEIPEFEVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E8</accession>
    <name>E8X2E8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase ChlI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1017</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1017"/>
    <dbReference type="EnsemblBacteria" id="ADW68080">
        <property type="protein sequence ID" value="ADW68080"/>
        <property type="gene ID" value="AciX9_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1017"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_0_0_0"/>
    <dbReference type="OMA" id="HASEQEC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="33347" checksum="3FEB512726237EF9" modified="2011-04-05" version="1">MLFKALSAAVYGIDAHIIDVEVDYSGTIQEKAEFSTVGLPDAAVRESRDRVRSAIRNSGFDLPTTRIIINLAPADIKKEGSGFDLPIAVGILGAYGGLHLKDLSDFLLVGELGLDGSLRSVQGMLPIAIAARARGIKNLVIPAGNAREAAVVEGVNVYPVKTLLEVRDLLNTAAFGAITAVPLRVETTALLNEMQHFPADFKDVRGQHVAKRALEVAAAGAHNILMIGPPGSGKTMLAKRLPSILAPMRFEEALETTKIHSVAGVLNADEGMVAHRPFRAPHHTISDAGLIGGGAVSNRSNANYSQGALTVRKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G4</accession>
    <name>E8X2G4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2144</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580504.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2144"/>
    <dbReference type="EnsemblBacteria" id="ADW69188">
        <property type="protein sequence ID" value="ADW69188"/>
        <property type="gene ID" value="AciX9_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2144"/>
    <dbReference type="HOGENOM" id="CLU_2206320_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234109" evidence="1">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="11524" checksum="C80DE25B96DC552B" modified="2011-04-05" version="1">MFPKETWISLALMAVTSAALFSFLGCAHHNSAIAQAQHPSVQNHVRSAKFQASAFTAQHQVATPAAHVKQAIRSADPHAPVLRPIVQNQKTAKKKLSKLPKTQPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H2</accession>
    <name>E8X2H2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580512.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69196">
        <property type="protein sequence ID" value="ADW69196"/>
        <property type="gene ID" value="AciX9_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2152"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120467_0_0_0"/>
    <dbReference type="OMA" id="VNSDFAT"/>
    <dbReference type="OrthoDB" id="1668457at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="14552" checksum="65A232BBC1E7EE06" modified="2011-04-05" version="1">MTWLGWALLSAVFAAATALLAKVGIKGIDSNLATAIRTTVVLVFTWAIAIGLEKHNGLAQIGRRSWLFLLLSGIATGLSWLCYFRALQMGPASSVAPVDKLSVVIVIICAWLFLGETLTPAKLLGGGLITAGAIVLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I7</accession>
    <name>E8X2I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2167</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2167"/>
    <dbReference type="EnsemblBacteria" id="ADW69211">
        <property type="protein sequence ID" value="ADW69211"/>
        <property type="gene ID" value="AciX9_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2167"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052747_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="28535" checksum="C9D8B83FE38D39A7" modified="2011-04-05" version="1">MNATGQASGLTCTPDSVVSCESYGVFFRVRVATPDLLAEVIKVLPHGSVLVAEVPAGAEEFTFSADSRTRKGFESSLEQLRQDLMVHVANSAPDHVFVHAGVVAWQGHGLMLPGESFAGKTTLVAELVRAGALYYSDEYAVIDQEGKVHPYARNLQVRMPGYALQTDMPVTELEGIAGTRPLSIALVAFVKFSRDEPWMPDSMTAGMSVLEMLRHTIPVQRTPARVMATLTSMLADASVIRSKRGEAGPAAHALLKLLEFHAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L8</accession>
    <name>E8X2L8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="12" type="ordered locus">AciX9_2198</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580558.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2198"/>
    <dbReference type="EnsemblBacteria" id="ADW69242">
        <property type="protein sequence ID" value="ADW69242"/>
        <property type="gene ID" value="AciX9_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2198"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_0"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="30861" checksum="9F7DCB312AEC853F" modified="2011-04-05" version="1">MAEMETIKQQMPAAPVPEAWVRTELARDPARPYPMDYIEALFTDFSEIHGDRAFGDDAAMTCGMARFQGTPVLVIGNLKGRTLKDRVTRRFGSPEPEGYRKALRAMKIAEKFGRPVFTFLDLAGAFPGIGAEERGQGEAIARNLMEMNRLRVPTLATITGEGGSGGALALAVADRVLMLENAIYSVISPEGCASIMWKDASKKQQAAAALKYTAKDTKALGCVDDVIGEPEGGTQADPGKAFTLVSRSLKKHFNEIKGMPIDELLEKRYQKFRNMAQFYTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X315</accession>
    <name>E8X315_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1086</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579472.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1086"/>
    <dbReference type="EnsemblBacteria" id="ADW68149">
        <property type="protein sequence ID" value="ADW68149"/>
        <property type="gene ID" value="AciX9_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1086"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_0"/>
    <dbReference type="OMA" id="YNLAHRH"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="31246" checksum="B904882E5B5C323A" modified="2011-04-05" version="1">MTNRLSLGGSFTFPGTTMTVKRMGYGAMQLAGPHVWGPPKDRAAAVGVLREAIEDGVDHIDTSDFYGPHVTNQIIKEALHPYKDGLVIVSKLGAKRGDDASWNAANSRQELIDGLHDNLRNLGLDAMDVVNFRAWGRTGPEPGSIAEPFSVLAELQQQGLIKHLGLSNVTAEQVAEAQTIAPVVCVQNQYNLADRKDDALIDLLAKQGIPYVPFFPLGGFTPLQASELDGAAAKLKATPMQVALAWLLQRSANVLLIPGTSSIGHLRENLEAAEIALPEEMIAELDGIGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A9</accession>
    <name>E8X3A9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="13" type="ordered locus">AciX9_3404</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581722.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3404"/>
    <dbReference type="EnsemblBacteria" id="ADW70410">
        <property type="protein sequence ID" value="ADW70410"/>
        <property type="gene ID" value="AciX9_3404"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3404"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_0_2_0"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="451"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="752"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="898" mass="98836" checksum="8B9E1C58BCE58238" modified="2011-04-05" version="1">MASTPNTPANPDLTPLDPNAQANTDAAKAAGYSAENITVLEGLAAVRKRPAMYIGSTGEQGLHHLVYEVVDNSVDEALAGYASRIDVTIHVDNSITVVDDGRGIPVDNKVINGVTMPAVQVVLTILHAGGKFDASNYKVSGGLHGVGVSCVNALSEAFDVEIWRDGFAWEMDYAAGDPISELRKMGPSTRKGTKVHFLPDKTIFSVTEYNYDTLANRLRQLAFLNKGIEITLTDERQTETKTGEAKTQSFKYLGGIAEFIKLINKGKAVLHEKPIYMEAERDNVAMEIAMQYNDAYSETVFTFANNINTVDGGTHLSGFKTALTRTINAAGQSLGLFKDVKENLSGDDVREGLVVVISVKLSQPQFEGQTKGKLNSDIAGTVQAFVNERLGAFLEQNPQVAKKIINKAIDAARAREAARKARDLTRRKGALDGGGLPGKLADCSERQPDRCELYLVEGESAGGTAKQGRDRKFQAILPLKGKILNVEKARYDKMLGHEEIRAMITALGCGIGKDDFDVSKLRYGKLILMTDADVDGSHIRTLLLTFFFRHMTELIKRGHVYIAQPPLFRIKKGKFEQYIKDEREYVNVMVKRASDGMVITHGEGGARIEGADLTEFIGRLNEYLGFLDKVNKRLRNEDVTRAFTELFAHGGATPAKKEDFQSPAKLEEMKTKLQALAHEAQFRAVGEPVLDEEHQTWSVSFTDAQGAERKIDWALANAAESRQLLGKYAQIESQLKGPFHISYAAKAAVPTPAAGSAEEAEATSQAEMDEADEVAQEEGINETIAAAPGTAAETKPGKRSNRASQDPVEKKTPREVFEYVIEQGRKEYQVQRYKGLGEMTAPQLWETTMDPERRTLMQVKLEDIAATEEIFTTLMGEDVESRRRFIEENALDVKNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G4</accession>
    <name>E8X3G4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitate hydratase A</fullName>
            <ecNumber evidence="4">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_3460</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3460"/>
    <dbReference type="EnsemblBacteria" id="ADW70465">
        <property type="protein sequence ID" value="ADW70465"/>
        <property type="gene ID" value="AciX9_3460"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3460"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_0"/>
    <dbReference type="OMA" id="GRASYMR"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="71"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="759"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="966" mass="104537" checksum="6F0006C68D60B0CA" modified="2011-04-05" version="1">MSLVTPHPNSFGSKTTLTSGSQKVTYFALDALKGFDLAKLPFSLRILLENLLRHEDGRTVTADDIRFLASWNPKAEPSREIAYMPARVLMQDFTGVPAIVDLAAMRDAMRALGGDPEKINPLQPAELVIDHSVQVDEFGTTNAYDMNAALEFQRNRERYAFLKWGQSAFNNFSAVPPGMGICHQVNLEYLARVVFTTQADAAGEILAYPDTLVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLVPQVVGFKLTGKLKEGTTATDLVLTVTEALRKLGVVGKFVEFYGPGISELPLADRATIANMAPEYGATCGIFPVDHETLAYLRLTGRTDDQIKLVEEYMRAQGLFHTPDAPEAEYSATMSLDLSTVEPSVAGPKRPQDRVLLSNAPASFAQQLPNLLGPVGNKGAVRQMVRWEGEGGHMSESGDVTSSVGAPSPGTDTHLPIADGLVPVSTLTAGPHAVHIDAPVTSVKGRYGVDVDQYLDHGSIVIAAITSCTNTSNPYVMMAAGLLAKKAVEKGLRTPPWVKTSLAPGSRVVTDYYVKAGLMQYLDALRFQVVGYGCTTCIGNSGPLPTDVSKSIEEHGLVAVSVLSGNRNFEGRISPEVRANYLMSPPLVVAYALAGTIHHDFEKEPIGYDPARQPVFLKDIWPTQQEVIDTVNSSINSEMFRKQYSTVSDGDQNWQNLSFPSGDTYGWEPDSTYIRKAPYFDGMPATPVDVEDIRAARCLAVLGDSVTTDHISPAGSIKKNGPAGKYLMEHGVEAADFNSYGSRRGNHEVMVRGTFANVRLRNKMAPGTEGGVTRLLPEMTEMSIYDASVEYARRGTPLAILAGKEYGSGSSRDWAAKGPRLLGIRFVIAESYERIHRSNLVGMGILPLQFEHGESAESLGLTGEEIFEITGLKEMLDSKFAAGKNITVKAENQTGTTMEFPVTVRIDTPQEILYYQHGGILQYVLRQLAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G7</accession>
    <name>E8X3G7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1095</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1095"/>
    <dbReference type="EnsemblBacteria" id="ADW68158">
        <property type="protein sequence ID" value="ADW68158"/>
        <property type="gene ID" value="AciX9_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1095"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_0_0_0"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="215"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="460" mass="50466" checksum="FA5E65CA103CD8D5" modified="2011-04-05" version="1">MLSGSSLAALPELAIVLGIMVLVHEFGHFAAAKLCGVRVEAFAIGFGKRLFGFIHDGTDYRINLLPLGGYVKMAGEMGPTGEDQVLTNDPGELQNHPRWQRTIIALAGPVANFILAFFLMMGVYMAHNEVMEYFSHTATIDYVSPNSAAARTGIQAGDKIVHFDTLENPTWEDVEVRAQLNLNQPTPFSYLHDGHRVDTKILVENKGRPDEFDFEKLGLVPVKQQTPPAVLSVSDKPNMPAARAGLQPNDRIESIDAFRPHSLAALIAYLQDANGKPAHLIIGRGTQTFPVDVTPEQGDNPDGTKAWQIGFRAQPSPTIIEHFSVAKAAAASWEFNKKNSLLIKDVLHRLFTRQVSVKSLSSPIGIGVQVHEAFDLPGWVPIIGTMALISLNLGIFNLLPIPILDGGMIAFLAIESLIRRDINQQLKERVYQVAFVCIVLFAAVVIFNDITKFIPTHIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K8</accession>
    <name>E8X3K8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fmu (Sun) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1136</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1136"/>
    <dbReference type="EnsemblBacteria" id="ADW68199">
        <property type="protein sequence ID" value="ADW68199"/>
        <property type="gene ID" value="AciX9_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1136"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_0"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="251"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="272"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="459" mass="49220" checksum="FA696F082DB4404E" modified="2011-04-05" version="1">MKSKGKSVKGDPLGFDAAAKVLAAGGRVPKKFAKARPVSAGPTLGAAQAQAKVTPARRAAFEILMLVKAGKGHSDELLHGQWTDKLSEADTNLTTALVMGVLRWEIALDARLRTLLQRPDQRLAEPVAMALRLGAFQLLHMDRIPAHAALSESVELCRAAGEPHATGMVNAVLRKVAALPKPGTKVFETTAAFAERLGHPLWLVERWVENYGRDAALKICEADQSESGEGGVFSERDAELPSIDDGSRLVAEIAAKALPQVEGRAARVWDCCAAPGGKTLVLAKRAEGAEVLATDVSTKRMGQMESRLKRFKYAKGVTCEVADAAKLPKDMGTFDLVLCDVPCTGTGTLGRNPEIRERLKVEELVRQSQRQREILAAALGRVALGGRLVYSTCSLEPEENERVVEAVIGSAWRVVPIEEMGVTGLAVEMHSMAQDGALRTLPGVHGCDGFYAVVLERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y9</accession>
    <name>E8X3Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581808.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70497">
        <property type="protein sequence ID" value="ADW70497"/>
        <property type="gene ID" value="AciX9_3492"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3492"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="WAPDETQ"/>
    <dbReference type="OrthoDB" id="1335347at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233639" evidence="1">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="28745" checksum="ECC6FAA402FC0473" modified="2011-04-05" version="1">MVRWIAVSGLVMGSLGLGAQGTVAGKAEPFEVATIKLVDPGERAGRFIRMEGDHRFIGKNYTLKLLIAAAYELNPKTISGGPGWVTEDHYDVVAVTPGEKKPSRDQQMAMLRLLISERFALKFHREQKEFSIYELSRAKGGSKLKASTQAPDEAPQTISTVYPQKIKMPARNVSMGDFASVLQRAILDRPVVDKTGLTGRYDFDLEWAPDETQLSGDIPAAPADSPSPPLFTAVQEQLGLKLEETKGMVNALVIDGAHRPLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X438</accession>
    <name>E8X438_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0007</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578427.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0007"/>
    <dbReference type="EnsemblBacteria" id="ADW67098">
        <property type="protein sequence ID" value="ADW67098"/>
        <property type="gene ID" value="AciX9_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0007"/>
    <dbReference type="HOGENOM" id="CLU_1633084_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="17616" checksum="149073D52496D847" modified="2011-04-05" version="1">MKKLALVGLVLLMGCGPRLYSGKGVVAGSGGTLGNWSHPPAGCIRDSAYQDEGQRSVATFLWKDLRILEPGPGYNDIWKNDTPIRLDLQRDGDGYTGVLRTFKQQLGWRIDKTACSEFEFTPHEGPAREPKGRPVLDGELKMDCAVAGGRLTANVSFKGCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X450</accession>
    <name>E8X450_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578439.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0019"/>
    <dbReference type="EnsemblBacteria" id="ADW67110">
        <property type="protein sequence ID" value="ADW67110"/>
        <property type="gene ID" value="AciX9_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0019"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459363_0_0_0"/>
    <dbReference type="OMA" id="YRPDRDY"/>
    <dbReference type="OrthoDB" id="1825732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19944" checksum="B89D2610BC407B0E" modified="2011-04-05" version="1">MATPVLIPVEQYLSTSYDPDCDYIDGEVQERNRGERPHSLMQLALSAIFYSNRRAWKVLPMPEQRVQTSATRFRIPDVCLIAASDPADPIVHIPPILCVEIISSGQTLRHMQERTDDYLAMGVQQVWVLDPVRREAFIPSPSGVLQPSPDNLNVSGTPIELSWTEILREYDDLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X454</accession>
    <name>E8X454_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="8" type="ordered locus">AciX9_0023</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578443.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0023"/>
    <dbReference type="EnsemblBacteria" id="ADW67114">
        <property type="protein sequence ID" value="ADW67114"/>
        <property type="gene ID" value="AciX9_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0023"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_1_0"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="7">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27069" checksum="C580D7A42EC7BF26" modified="2011-04-05" version="1">MFFHLLSPGRISYAEGLAMQQRVSAARKAGQVGDTLILLEHPPVLTLGRNSKRENVLATDALLASKGVELHEVNRGGDVTYHGPGQLVGYPIVDLRGDLPGKKGPHLGPVDFVRLLEEVLIRTCGEFRVMTQRVKGRTGVWTLANGSLEERKIAALGVHVSQGVTTHGFALNVTTDLRDFEWIVPCGITDRQVTSLELESPLEPVPTLAEALLCTSRNFGKVFGRQVLAANSLEALLADGAASHLAETAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E8</accession>
    <name>E8X4E8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1212</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579598.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68275">
        <property type="protein sequence ID" value="ADW68275"/>
        <property type="gene ID" value="AciX9_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1212"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641375_0_0_0"/>
    <dbReference type="OMA" id="AREPHRN"/>
    <dbReference type="OrthoDB" id="1786108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17750" checksum="198B21625BE9DE79" modified="2011-04-05" version="1">MTPEASFTDAALRQWKQQADRTAKILHALSDEQLQQPVAPGKNRLSYLFGHLLAINDAMLPLLGLGARQHPELDAIYLAAPDRTQPQTLAAAELKQQWDQNAEALWTAFNTLTPAQWLERHTAVSEEDFAREPHRNRFAILLGRTAHLAYHAGQIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H9</accession>
    <name>E8X4H9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580705.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2352"/>
    <dbReference type="EnsemblBacteria" id="ADW69389">
        <property type="protein sequence ID" value="ADW69389"/>
        <property type="gene ID" value="AciX9_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2352"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_2_2_0"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="19203" checksum="A0C02EDA1CBA8259" modified="2011-04-05" version="1">MAIDPIDDQDLDIEVQIRGLMLDPVTNMPIVVLKDVASDLVLPIWVGVFEANAIALELEKTATPRPMTHDLLRNMARGLNATVHKVVVSDLRDDTFYATIWLMQGEEEVTIDARPSDAIALALRWDCPIYVSQSVLGRTRQAATEAGANANADELRRWLENLNEDDTGQYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X594</accession>
    <name>E8X594_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579681.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1296"/>
    <dbReference type="EnsemblBacteria" id="ADW68358">
        <property type="protein sequence ID" value="ADW68358"/>
        <property type="gene ID" value="AciX9_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1296"/>
    <dbReference type="eggNOG" id="COG2947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_2_1_0"/>
    <dbReference type="OMA" id="WDGIANN"/>
    <dbReference type="OrthoDB" id="1829674at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="14218" checksum="55BFED59923E7B63" modified="2011-04-05" version="1">MPFLLKTEPNKYSYDDLLRDKETVWDGIANNQALLYLRNMKKGEKLVIYHSNIGKAAIGTAKVVSVDATDPKNPQVRIAPGKRLKNEKPLDQIRAAAVFTDSILFRQFRLSVVPITDEQYDWLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M0</accession>
    <name>E8X5M0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3644</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581958.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3644"/>
    <dbReference type="EnsemblBacteria" id="ADW70647">
        <property type="protein sequence ID" value="ADW70647"/>
        <property type="gene ID" value="AciX9_3644"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3644"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OMA" id="RIIMMST"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26139" checksum="E5B539121BF02BB9" modified="2011-04-05" version="1">MGKLEGKVAVITGGSSGMALASAKLFVEEGAYVFITGRRQEQLDEAVKLIGRNVTGVCGDAANLDDLDRLFETVKREKGRIDVLFASAGMGEPLPLGQITEKHFDAAFNLNVRGTLFTVQKALPLFNDGGSIFMTGSNAAAKGFPGFGVYAASKLALRSFARTWLNELKDRKIRVNLLVPGAIATPMQEEVLTPEAKQYFESLIPRGKMGQPEEVATVALFLASDDSSFVNGLELFVDGGMTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q3</accession>
    <name>E8X5Q3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581989.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3679"/>
    <dbReference type="EnsemblBacteria" id="ADW70680">
        <property type="protein sequence ID" value="ADW70680"/>
        <property type="gene ID" value="AciX9_3679"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3679"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105789_3_0_0"/>
    <dbReference type="OMA" id="HDRNHLL"/>
    <dbReference type="OrthoDB" id="1812981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17520" checksum="857E69609A7CD0A1" modified="2011-04-05" version="1">MVLNPYAAFLGEQDARAVLAATPGLIHQSVCALTPEQIEAPLSAGKWSPREIVSHLADCELAFSFRLRQTLAEPHPVIQPFDQDDWAKRYSVYTLPEALELFRAARQWNLKLIGGASAADFERMVTHPERGAMTFGTIVETMAGHDLNHLGQLQSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T6</accession>
    <name>E8X5T6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate_lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4024</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70820">
        <property type="protein sequence ID" value="ADW70820"/>
        <property type="gene ID" value="AciX9_4024"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4024"/>
    <dbReference type="HOGENOM" id="CLU_031144_0_0_0"/>
    <dbReference type="OMA" id="QVAGIAW"/>
    <dbReference type="OrthoDB" id="765411at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234218" description="Alginate_lyase domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="45579" checksum="B944C50E0D226B95" modified="2011-04-05" version="1">MQVLNFIGNLDRRAFLKTAAAASAALTLNPAWAKAPAEKEDGHALVAKTDRQRILTAANLYLAQKPATITDFPTKRSPGGLHDFYSQADYFWPNPKDPNGPYINRDGQSNPENFADHRKAMIRLSVEMPALTAAWVLLGDKQGKRYGEAACAHLRAWFVTPATRMNPNLEFSQGVKGVSTGRSFGVIDTLHLVEVARAASFLMGTLLSPEDSAGVKTWFTEYLSWLKTSKFGTTERDALNNHSMCWALQAAEFARLIKDETTRAEVYHQYITILLPNQLGPNGSFPKELLRTKPYSYSIFNFDVMAGLCQSLKGVQQDATKFALPDGRGLCKSAEFLYPFLKDRNAWPYAHDVEHFDALPVRSPGLLFAGLACHQQPYLDLWKSLNPDPTDREIIRNYPIRQPLLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U4</accession>
    <name>E8X5U4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4032</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572740.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70828">
        <property type="protein sequence ID" value="ADW70828"/>
        <property type="gene ID" value="AciX9_4032"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4032"/>
    <dbReference type="HOGENOM" id="CLU_1209390_0_0_0"/>
    <dbReference type="OrthoDB" id="1632747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="22900" checksum="9CE1BECA9B6A3F54" modified="2011-04-05" version="1">MPNQSGILYGLTILSPIIDDERATPSHDLQIRKHLAGLPTDQHSPFALAAGTHLARIAVMDDVIYVGMPSCEEHLKSKYLVFESNCDGDLEGYLGGLADAVPEQLDAIWSHCVGYPGAADRWAFIQYMKSCQLDTTFYFAAINNKTLPQALRALYTQHAVTNFIASHQGMAPAQLQAEFLQFTQDLASEPTPPAGSMGPHRGIKTGGRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V6</accession>
    <name>E8X5V6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4045</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70840">
        <property type="protein sequence ID" value="ADW70840"/>
        <property type="gene ID" value="AciX9_4045"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4045"/>
    <dbReference type="HOGENOM" id="CLU_267617_0_0_0"/>
    <dbReference type="OMA" id="YGTAPFT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234222" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="3">
        <location>
            <begin position="778"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="3">
        <location>
            <begin position="877"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1137" mass="111077" checksum="3313054617A9C426" modified="2011-04-05" version="1">MRTLCVTKHARNIAAIMLAIAASIGTTALGQSFTPPAAATFSSTMPYSDLVQSQALATDSSGDIFFSRPASGILAEKPASGGAEIILYTAPSGSGGYPKGVAANDTYAYLTDYSGHLWQVPIGGGTATDILSTCGSIDNGYLGTQDVATDGLGNVFVAGNNETTLFKITQAGACSTVGGITLDANSHVAADAAGDLAYSTAGVLYSMPAGATASVAVPGTFNTIIGLRSDASGDVFVTTYSGIIEVPFISGTLDGTRAFTVLTASSQNDVAVSPNGVLLTTDGTNIFRNVLGAIRYGSTAVGIKSSVQTVSVIFNSAQVLTGIRYAAGTGSSTEIVSAGSGSCAIGQSYVAGSSCTLDLTFTPQSIGARNGAVVLSSAAGVIGTVAVAGQGSGAGLVLDPGTQTNVGSAWQSPSGIAVGASGELLVADKTAGTVSYFAPGSTTAVVIASGLTQPTAVALASDGTAYIETATGTVIQVPYNGTAYAAPAAIATGLKSPGAIAIGPGGSLYVANSGAGTVVRYPNQSGTRNFSASSIVGSGFKAPAGIAFDASGSLYVADSTAGSISKITGTTASVIAAGLTSPNAVAVDDSGSLYVLSAGSATILRIPFTGGSYGSNSATSLGVGLTSLASFAADSAGNLYVADSGAPAVAAIRRTAGLLNLGRINVGSSSSAQSLSLSNDGDLSLALGSPLFTTSGNTTDFAVSTSSANACASGGTLVTGATCAVSGIFTPTAVGTRTETLTFNTQATNATAIAGAFTGTGINLPKTTLSLTINPSGTVPYGTTVTATAVVGAPAGSTSAPTGSVTFLVNGTTYKVVTLVNGTASASITGLAAGNNTIDASYSGDATYAASSGVTQSIVVTLAPTTTTFTSSITSATPVAPGTSVTLTATVLASVTGAKPTGTVNFVSNGTTLVSAVVNSSTGVATVTTTALPAGVYAIAAVYGGDSGFAPSTSAAISVAIRVQQFDIGNAPSALNVSAPGSVTTSFSIIPIGGYVGGVDIACSGLPANTQCTFLPATLAFSGTATPQTVQLIITTYTPAPTTVAWVMPFGMLLMIGMARRRKALGVMRSFGTLALLLSIGTALLAINGCAGTSSPTPKGTSNVTVTLTGTPNGSTTIPANGTGNIVKTISLTLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X654</accession>
    <name>E8X654_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70938">
        <property type="protein sequence ID" value="ADW70938"/>
        <property type="gene ID" value="AciX9_4158"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4158"/>
    <dbReference type="HOGENOM" id="CLU_634266_0_0_0"/>
    <dbReference type="OMA" id="GMAVHLH"/>
    <dbReference type="OrthoDB" id="683443at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="258"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="441" mass="47742" checksum="165731C5231F4474" modified="2011-04-05" version="1">MVAVLAGVGGVAAGQRVTAPVPAAVTRDLDPGLMKVIDGARAVDNHAHPVLPPPNDKTDREFDALPVDNMEAETDTVAWRTDNPQLPEAWKALWGFDGKVPLDEAGMKGLNAARERVKAAKGTGYAAWVLDEAGVGTMLGNRVAMGPGVMRPRFEWVPYADALLLPLDTSRLAKGSPDKALFYPMEDTLRGKYLKALGMGAVPGTLSEYLAKVVTPTLERQRAGGAVAEKFEVAYLRGFDFTVVTRERAAALYAKGALSAGEYKELQDFLFRYIALECGRLGMAVHLHVMAGGGGYFGVAGADPLLLEPLFNDSALRKTKFVMLHGGWPFVREAGALLQKPNVYLDLSQEALTFSPRTLSGWLREWLETYPEKVMYGTDGYPLSDAMGWEEATWIADRNVRLALGLALTGMLRDGEVTRERAEGIATEVLRGTAAGVYGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X671</accession>
    <name>E8X671_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4176</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572867.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70955">
        <property type="protein sequence ID" value="ADW70955"/>
        <property type="gene ID" value="AciX9_4176"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4176"/>
    <dbReference type="HOGENOM" id="CLU_1914114_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="15233" checksum="88FBCA799F074038" modified="2011-04-05" version="1">MAIKFHPQWKIADPWYTQRYGSYQVFLDSVNQQQIMAALWAANGHFRGQPWVTEILQDAASTSQHSYDVTIEQGVHQPESYAGEDGFILHFTMRNSRGRAYHLYVKQKDNGALTINEISFMRNGAQVQVFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D3</accession>
    <name>E8X6D3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_4241</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
            <plasmid evidence="14">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572929.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71017">
        <property type="protein sequence ID" value="ADW71017"/>
        <property type="gene ID" value="AciX9_4241"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4241"/>
    <dbReference type="HOGENOM" id="CLU_014298_0_1_0"/>
    <dbReference type="OMA" id="CFDYPGQ"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="50"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="266"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW71017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="772" mass="86204" checksum="998FBC5AE811AAED" modified="2011-04-05" version="1">MRSVMLGLVVCLCAVHGLTQGRRQANAAGPHVFGDLKVEQYAPSRSYHVENYKVTARIDMEKGEIFGDEVVTLRPLGAGLKSFYLDSSQLQIDHVTLKGAALPFHLDGDKLWVTLDRGYSPADALDVRIVYHGNPQGRPFPDAGLSFIRPDAVNPKRPLEVWSYGWPQNNHFWFPCWDYPNDKSTSEVILTVPEPLSVVSNGALVKETHANGLATYDWAEQVPHSVYLVSIAVGPWTKYSQRYGSKAVDYYVPPGVDEATALRSFGLTPEMMAFYSKIYGVDYPYEKYAQTADHAFGGGTENISATSLAETTLHDARAEQDFPSLDLVSHELAHQWFGDLITEWSWDDAWLSEGFATFSAALYRGHHEGYDAFRYQIYEDQQTAMREDIGRYRRPIVDRHYTKPWEILDRTTYQKGAAVLDMLRYVMNDGVEKTPTADEPYFRALQAYLTAYRAGNVDTQNLIDMIRKTTGLELSWFFDEWVFKGGYPEYEVSTAYDSARRDEAVTVRQTQTVDAVTPLFDMPVHLVFHGAHGERQDEMERVHQLAETFHVTVGWTPVWVEFDPNDHIYKTLKIAEPVEALVARGERGETMMSRLWAAEQLGLVKGEGGKAAEEALMRMLERDSYWGVRVASAKALGSMGGEPAKSALLLALKQPNSHVRTAAVQALGQFAKDAGVRAMLMEHMRDDDSYAVEAMCARTLGSSGGAEALTALEAEVAVKPSHYVMAGVLEGLSHYKDATAQAIVMEQTKTGSTDEVREMAAFALTKMKAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F9</accession>
    <name>E8X6F9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4270</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71043">
        <property type="protein sequence ID" value="ADW71043"/>
        <property type="gene ID" value="AciX9_4270"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4270"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_0"/>
    <dbReference type="OMA" id="CPSNARG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="44966" checksum="DC8936F6A93438F1" modified="2011-04-05" version="1">MSTPVISSNRPVSHLPAVKLRPADEPWIFAFLAGISGWTLDAFDFFLVVLSLTAIGHEFNQDVKHMTLALTATLALRPVGAFLFGGISDRFGRRLPLVANLCLFAVVELSTAFAHSFLSFLIVRAVFGIVMGGQWGVGVSLAMEKVPARLRGVLSGLLQQGYSIGFLLAAAAYYVIQPVHGWRPLFYLGSIPALAAAAMVVWKVRESDVWLRNRQSSFAGLGRDLMSHWKLFLYLTFFMMAMHMSSHGTQDLYPTFLERDWGIAGRQKAALTAISMGGAVLGGLSIGWISDRVGRRTAMVGALIGAVCSIPLWAFAHTLPLLILGAVLMQFCVQGAWGVVPAHVAEMSPDSVRGTLPGLGNQVGVLLSSVVVYLEAALAKGRSYAVSMSITAAVVFCLAALLTLSGRERRSDGLAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H2</accession>
    <name>E8X6H2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572966.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71056">
        <property type="protein sequence ID" value="ADW71056"/>
        <property type="gene ID" value="AciX9_4287"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4287"/>
    <dbReference type="HOGENOM" id="CLU_348115_0_0_0"/>
    <dbReference type="OrthoDB" id="99961at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234444" evidence="1">
        <location>
            <begin position="22"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="828" mass="93044" checksum="79215E6A44333926" modified="2011-04-05" version="1">MSRDVSIAFVCCLIGAGVLNASPVVVPSTDSGTVIEVAFPVKQTVQEMTALQVLTEESGKRGRVTWSSESGRLNADHFQPYVVVLAQRDQVEQVLPQSLVGTWRDHLLRLHPSNAAEAFTIVTLPWKDKAKTGIVQVISGNDVRGELFGVGWLLRHMSFEGGTVQLPQSPEIFSAPDKPIRGHQIGYRFKNNTYDAWTLGQFEQHIRDLAIFGTNTLQLISPVSDDNPLSPLMPAPPLETFLGISRLLDQYGLRCDLYYPEMRKDYSDPAQFQAELKDFEALVRRMSRVDSVHIPGGDPGHTPPEILFPLAAAEVRIIRKYHPSAAVWISAQGFDAEQYESFYTLLGSGQDWLTGVFFGPQSRDGMEIQRKRVPGRYSMEFYPDIAHVMHAQFPVPGWDPVFALTEGREPICPRPMAFSRIYKDFQDLNGGFITYSEGVNDDVNKILWSQLGWMPGTPIDTILGEYARWFLHREGEQLGQAVALIEGLEQDWDGPLLENRQIAKTFELTRHLEDSSNTAQSQGNWQWESLLYRGYYDMYLQRKFAREQSAQHEAEHALVSGGRSASRVKIAERSLNESKPGVEEQREHDELFKLGEKLYDDIGLQLSVKLYGASNWERGANLDRVDTPLNDRAWMRAAMAKAEAQPTETAKISALEAIANWQMPVSGALYDDLGSPAHESHFVRGEGWQKDPEMYHTAIDGIADRTLEDGWRLSWLSYAEALYEEPLDLEYKDLDPSKNYRVRLTYAGEDYAVPLTLTAGDVVIHSSRLRQSNPETYEFELPKEAIVNGTLHLRWMRGTPGGGGGGRGRQVAEVWLLPQLAATAVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L0</accession>
    <name>E8X6L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3879</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582179.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71160">
        <property type="protein sequence ID" value="ADW71160"/>
        <property type="gene ID" value="AciX9_3879"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3879"/>
    <dbReference type="HOGENOM" id="CLU_077149_3_1_0"/>
    <dbReference type="OMA" id="AYHSHNF"/>
    <dbReference type="OrthoDB" id="1884218at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16500" checksum="26AA7214601E01F4" modified="2011-04-05" version="1">MAAVLRAFFFYIFLVFIVRVVGRRPGKQITPFEFVLVFFMGGLALTAMVGDDASLTNALLQIITIAFAHYGVAFLRSRSNRLARLFDGTPLILMKDGLWRAETLSKMGIQDDDVMATARDQGILTLDQIDLAILERNGEISIVKKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S1</accession>
    <name>E8X6S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Precorrin-3B synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71221">
        <property type="protein sequence ID" value="ADW71221"/>
        <property type="gene ID" value="AciX9_3945"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3945"/>
    <dbReference type="HOGENOM" id="CLU_015667_3_0_0"/>
    <dbReference type="OMA" id="AKGCAHP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012798">
        <property type="entry name" value="Cbl_synth_CobG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02435">
        <property type="entry name" value="CobG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="421" mass="44135" checksum="AC82EDC28F22D9EE" modified="2011-04-05" version="1">MRLGENFCPGILHAVPAKDGQLIRIRVPGGLISAAQLAAVASLAASHANGEIELTSRSNLQLRAIQPSSLPYIVTTLTEAGLLPSSAHDRVRNLVTSPFAGIDPAASLDTRPLIRALDQRLIANDLFLQLHPKFTFGIEANPTRFTYEVEDLGLQAFDSTHRLSLSLAGKDTGCSVAPEDAVVCLLTAAEACIDLAKQHNVPVRTKRLTAIPGVLETLLKTLSPLLEPTTNPARGPDVRRDVIGPHPALTPGHLNLVPSIPLGHLTASQATNIATLATQHNADLHLAPWRGIVLGNLTPKAAALIAPQLAALGLPLDATNGFEGIAACAGISRCDASLADVRADAARLATYLATRPHIPGWTIHLSGCEKQCALRHSASAALIATPAGYTLRLPNHPEAHSLPSAAAIASILQSHTEALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X716</accession>
    <name>E8X716_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3839</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582147.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71125">
        <property type="protein sequence ID" value="ADW71125"/>
        <property type="gene ID" value="AciX9_3839"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3839"/>
    <dbReference type="HOGENOM" id="CLU_028458_3_0_0"/>
    <dbReference type="OMA" id="PPEPIIF"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="29232" checksum="5DFC6F585577212C" modified="2011-04-05" version="1">MKFISFTHEGSAGSGVLRDEKVYPLTGDLLSHIASGDTQPALTGAAIPLSSVQLTAPLLNPPRIFGIGLNYREHAAESKMKVQDVPTVFLKLSQSLCGDGDDVLLPSDATQPDYEAELAVVIGRGGHRIAEADWQQHVFGYTILNDISARGVQLATTQWTLGKSFPTFTPLGPTIVTADEVPDPHALYIRLTLQGEVMQEANTRDLIFRIPALIAYLSSITPLMPGDIISTGTPPGVGLGRTPQRWLLPDEEMVIEIEKLGTLRNRTRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X746</accession>
    <name>E8X746_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4327</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572999.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71280">
        <property type="protein sequence ID" value="ADW71280"/>
        <property type="gene ID" value="AciX9_4327"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4327"/>
    <dbReference type="HOGENOM" id="CLU_102501_0_0_0"/>
    <dbReference type="OMA" id="YSHPWAW"/>
    <dbReference type="OrthoDB" id="1574258at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="28009" checksum="33BC8D1C90521FCF" modified="2011-04-05" version="1">MSELPIDLGTGKPMPPREQPGYYPGFSTVSQKAYWDAATRAVVLRRLEQPKPLRFFTAAEAVTMEAVTARVMPQEDRIASRRIPVLAGIDERLAENRIDGYRYEDMPADQEAYRLGVLAFETMAQEQHAGPFAGLTVMQQEELLKSLNEGKPFAAKELWAGMNVQRFWSMLVGDCCAVYYAHPWAWDEIGFGGPSYPRGYMRLEGGEPEPWEVEEQRYEWAPPPDTLSAEEQGSEHTHAENTPGQGGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X777</accession>
    <name>E8X777_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4359</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71311">
        <property type="protein sequence ID" value="ADW71311"/>
        <property type="gene ID" value="AciX9_4359"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4359"/>
    <dbReference type="HOGENOM" id="CLU_1785957_0_0_0"/>
    <dbReference type="OMA" id="ITAYSFP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="16702" checksum="C068B233B3CB737C" modified="2011-04-05" version="1">MTKYPRAVNPPPTFEYRKNMIRPCFLVIDKEFAGSISTRKLVIETAKFNVITAYSGSEAIATLERFPAVNGIVLDAGVSDIPLSELCKTLKKMQPAVPLVLVGRPGVQQTQDADHYVDSFDPTQVLKLLRSLEPRQAAEIEQRDAALESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X796</accession>
    <name>E8X796_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ig family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4378</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573049.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71330">
        <property type="protein sequence ID" value="ADW71330"/>
        <property type="gene ID" value="AciX9_4378"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4378"/>
    <dbReference type="HOGENOM" id="CLU_001292_0_0_0"/>
    <dbReference type="OMA" id="GTGPYTC"/>
    <dbReference type="OrthoDB" id="240588at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1565" mass="154528" checksum="86105F6EAF4BE746" modified="2011-04-05" version="1">MSNIPAVKSLLDLSWSTRSFKRLVAIFRSDKAFASFTLISIGMFVLSGCGTGGYPGGGIESLSVSTSTIDAGQSIPVTALVSGSSSVTWSLSGPVCVDTGCGSISNVTGKTTTYTAPASLTSPLKVVLTGSVAGTTNHQIDTITVNPDPIISGTPPAGVVGLTYSTTLIAVPGTAPMKWSIVSGSVPPGLTFDTTSGKIAGTPTIPGTSSITVQLTDSSDIPFSVTAVETITITAAPLPLVVLAGNPPLGTVGLAYGTTIHASGGVLPYSWSLASGSLPPGLTLSASTGVISGIPTLPGTFVFTAQVQDAVGTRATGVFTITISPAPLGLTTGTLPTGTVGVPYNATVAVSGGTGPYSCSLTGPLQAGLSINACNVSGTPTVSGTVSLVVKASDSSNPTLITTGTVGLTINPAPLVITTSTLPNGTVGIPYSATIGVSGGTAPYTCSLTGPLQAGLSITACTVSGTPTAAGTVSLNVKAYDSSSPILTTNGPVGLTINPAPLVITTTTLPNGTVGIPYNATIAVTGGTAPYLCTLTGALQAGLSITGCTVSGTPTVSGTVSLNVKASDSSNPTLTTTGIVGLTINPAPLVITTTTLPNGTVGIPYNATIAVTGGTAPYTCTLTGPLQAGLSITGCTVSGTPTVSGTVSLNVKASDSSNPTLTTTGIVGLTINPAPLVITTSTLPNGTVGIPYNATIAVTGGTAPYTCTLTGPLQAGLSITGCTVSGTPTVSGTVSLNVKASDSSNPTLTTTGIVGLTINPAPLVLVIASPPPATVGVPYTGPISVTGGTGPYTCVLTGGTLPAGLTISNCTISGTPTTPGTTTVTITATDSSSPTITTTGPVTIVVNPATPTLTITSPPDATVGTPYTGPIGVTGGTAPYTCTLVSGTLPPGLTINNCTITGTPTTPGKTIVTITATDSGNPIATTTAPITINVLPVPPLTFTGSLPNATLNVPYTQTLAAAGGIAPYTYTITAGTLPPGITMSSTGVVSGTPTVVGASSFTVTATDSEGTPQTASLPLVLLVVYPTTPNDPELKGPYAFLFQGYDDEVAGALSYQTATVGSFTADGTGVLTSGELDSNHQSSNPTGTTIATNELLGTYTIGTDNRGTLAITTLNADGTVAGTATYAITLKAPVAPSTISVQADFIESDSNQLQGTKGSGTLLAQDATSYTAGLTGSYVFGLSGETPCLPACTIGISAGPVASVGVFSTDGAGNLTAGTSDENIASTKYPNQALTGSYTAADGNGRLQLTMPTAGAPAGVYPSDYAVYVVSANRAFILSNDKHSSYVLLGGSAQKQTQTSFTNLSMTGPYIGYENSPTNPGLIGVTLQNVLNLSSATIFRGVGDGAGNCNTTSVDTGGLTQLANGLTGLGSGVPILNALLGSYASTGNSACTVAGNGRVVLNYPAPSGLLPGILALLGLPDVPPPARVAYLASPNQGYFLETGYAGLGNLEAQTGAPFTLANTFTGTYVYGSAPASTVASIDSAGFIQSNGDGTATSTLDLNIGVGTINVLQLGVTTPSTYTAPDSTTGRFTLNGTTVVYAINHNRYVLVDENPLTTSPSVTVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P7</accession>
    <name>E8X7P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4545</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71481">
        <property type="protein sequence ID" value="ADW71481"/>
        <property type="gene ID" value="AciX9_4545"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4545"/>
    <dbReference type="HOGENOM" id="CLU_2825089_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6802" checksum="3A82EECD0B30ED6D" modified="2011-04-05" version="1">MPVLRDFIKRLGSLEESICSKCCQVVRTSDEAPTLLKAQAQHVCSEFSLNTVQRGEFAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P8</accession>
    <name>E8X7P8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4546</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71482">
        <property type="protein sequence ID" value="ADW71482"/>
        <property type="gene ID" value="AciX9_4546"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4546"/>
    <dbReference type="HOGENOM" id="CLU_2273411_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11381" checksum="47C141DE54239C24" modified="2011-04-05" version="1">MADVLKDKVGTHPASSCAVVEHTHPGFAELLQSSNTVKAVDRPRRHKQFGSGVIANRVLLLNALRGILLHETWTAESFQKLTDSIRKDKKKMASDVMKQYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X818</accession>
    <name>E8X818_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4673</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573320.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71602">
        <property type="protein sequence ID" value="ADW71602"/>
        <property type="gene ID" value="AciX9_4673"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4673"/>
    <dbReference type="HOGENOM" id="CLU_1243869_0_0_0"/>
    <dbReference type="OrthoDB" id="12517at57723"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="23865" checksum="F82A072BD7353679" modified="2011-04-05" version="1">MGLASLLTQLRRSFTVDTDASISKPKAVRAPAAAEDFTGLYTKPPTSSATKFPGVPAPDVALAPSLLAARWVSHDLYGEEMPGIAADLLEAGFDTPAVRRLAGETQVNNSADAEPLVSRMFRELGIPPSLGQQEAKLIVSRQLAREVIAGWRNAWATASHLEIVIWEHLPPNADLSAIFQINGEIDWDAPYRRSLPDLSAALLEAFADLGTMAIEDVDVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV69</accession>
    <name>E8WV69_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0170"/>
    <dbReference type="EnsemblBacteria" id="ADW67244">
        <property type="protein sequence ID" value="ADW67244"/>
        <property type="gene ID" value="AciX9_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0170"/>
    <dbReference type="eggNOG" id="COG3401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="GGRFPPK"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1005" mass="108706" checksum="9EDE1BBB9B7410EF" modified="2011-04-05" version="1">MSDNPETHPQSLLQTNSESQRSAKNPHNPHTFVTAPESKDSSSSSKTPEKISPMAHRRLTWTVALALSFAAPSALFPPTALAQSQIQATQVSGAITGTVSDPSGARIPNAAVHVENDRLKRDTVTDAAGRFSLDLPTGTYKMDILSDGFEPFVREGIAIAGKALKPLVLTLPIATSNEIVTVDASKLAGTGADENASSLVFDSKNLDTLSNDDATLQQQVLAIAGGDGQHPPQIFVDGFSGGRFPPKSSIREIRINQNPYSAAYDGLGFGRVEILTKPGSDKLHGFFQTQGNDRAFNSNNPFTGAQPPYHTLNLDGNVSGPIGKKTSFFLAGTYNDQQNNTVVNAQTLDANNNPFTFSQAIPDPQVFHTYSARLDRQLTKNNTLTSRYEYNQINMTNGGIGLLVLPTEGYNNSTTTQTLQIGNSEIIGPHLINDTRFQYIRTRLAQTPVSSAPTVIVQGVFSGGGSALGLFHDNQDRYEFQDYLSIDHGKHFLRLGIRYRLLRDSNLSNANYNGQYIYPDLNTYQITQQGLANHLTAAQILANGGGATQFSLTAGQSSAAITTADVGIYADDEWKLNKNVTLNFGVRFESQTAIPDRSDPAPRMGFAWAVHQADKHPAWFVLRGGFGLFYSRFDAPAILSAKRQNGVTQQSYFVQNPDPTVTYTPANLTGTAPTIYQIDPHLRSNYDIISGLSVERSLGKIGSITVNYLNIRSVHQFVSLNVNAPLPGTYDPSVPNSGTRPLGGTQNLYQYSSAGEGVGNILFTNYNLHPVKWFTAWGFYVNQHAKSDAAEPGGYANFVSNSYNPHADYGASSYDVTNRLFTGGSFNLPKGITLEPFFIARGGRAFNITTGADNNGDSIYNDRPAFATDLTRASVVKTSFGNFDTSPIAGQKIIPSNYGRGPTYLSLQLSLNKSFKFGPRRVEAPDPSAPPPPPPAKGAPTPKPDPAYELGFSAEGQNVLNHVNGAIPIGVLTSPFFGKSLSLESGFFNNSAANRTINLRAFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB1</accession>
    <name>E8WVB1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0212</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0212"/>
    <dbReference type="EnsemblBacteria" id="ADW67286">
        <property type="protein sequence ID" value="ADW67286"/>
        <property type="gene ID" value="AciX9_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0212"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330863_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="3">
        <location>
            <begin position="524"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="611"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="866" mass="88391" checksum="DA5D6C56760E91E3" modified="2011-04-05" version="1">MGITFDPTTIASIGEIPITVVNPAPGGESAPQTLTLYQQIVNAGVIIVSVPTTGKLYLASNSGYSSLRPNTVVPVDPTTGTIGTPIAVGKDPSLMAASTDGAYLFIVNRSDSTIQRIALATNAVDRTYPFPPNIFCPTCTAPSVTAIQPVPGVPTQFVIAQDSYLSLYDDPGLINELSTPTYGSLSTDYLTFAGAPAHLYSAPFSSSDNFFKQFTIDATGVHPLTTTGTAPTVPNELDHSLASIGTQIFTDTGHVWDAGSKQLLATIPVGIININSGFASVAADPNQKQVYYGGELQSASSVSITAYDTTTYAPKTSLAFTDTNLLYTTNLSRWGKDGFAFIDHNADLVLFRSSVLAGTSLLAPAITFTVPDHNYGDAAFAVNATSNSTGTITYSVLSGQATLSGNAVTITGIGAVTLQAIQSADGNYAEAEVSATFNVTPTPPVLTFTVANHTYGDAALMLSASSTSPAAIAYTVVSGPASISGNTLSINGAGVVQVQASQPASGNDAAATQTATFQVSTAPLTLSANNASRIYGTPNPTFSGVIVGTKNNDTLSENFTTAATQNSPVAVYSIVPSISGAAAGNYTVIATNGTCTVTQAAAGVSLTPSSTSVTPGQSATVTIAVTSSTTGTPTGVVTLQDNGASVATLALTNGGTTYSAILPSGITHHFSATYPGDANFTAATTTTTTSVVVSGTDNAFISSTSTQQAVAGSAVVYTLQLNPGAGSYPAPVTFSAQGLPSGFVASFSPSMVNVGTTQQTVQMTLQAPAIKAQVDIPPSRLIGGSLTFTLAFAVLPLVGLRRSRLLRNTTRNSLAFVCAMAFGLLSVTGCASNPPTATQPQTQTYTITVTAISGTVQHQTTVTLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS0</accession>
    <name>E8WVS0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2572</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580914.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2572"/>
    <dbReference type="EnsemblBacteria" id="ADW69599">
        <property type="protein sequence ID" value="ADW69599"/>
        <property type="gene ID" value="AciX9_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2572"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_15_4_0"/>
    <dbReference type="OMA" id="WVFGDRD"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025960">
        <property type="entry name" value="RVT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13655">
        <property type="entry name" value="RVT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="488" mass="56701" checksum="0A256FFABEAA6ED2" modified="2011-04-05" version="1">MNVEQSMCAASGPESQWEQIDWSQCEQKVRRLQARIFKATQEGRHGKVKALQWLLTHSFYGRALAVKRVTHNQGKNTPGVDGAIWRTPASRYKAIGTLRRRGYFPLPLRRVYIPKSNGKLRPLGIPTMKDRAMQALYLLALLPVAETTADPNSYGFRPKRSTADAIEQCFTVLARKISPPWVLEGDIRGCFDNISHAWMLDHIPSDKEVLRKWLKAGYMENRALFPTEAGTPQGGIISPTLANLTLDGLERLLKKTFRRREIRGKRYNLMVNFVRYADDFIITGCSKELLENEVKPLVERFMLERGLQLSPEKTCITHIEQGFDFLGQNLRKYGGKLLIKPSKKNLHAFMEKVRGEIRSNRATKQEHLIGQLNPVIRGWAYYHRHIEAGSTFWKVKNDLWHLLWRWAKRRHPNKNSAWIVNRYWHWSAGCSWCFATVTASNAQRSRSYEVRLVNPSDIPIKRYVKVKSDANPFDPHWRAYFESRKRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW20</accession>
    <name>E8WW20_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein AciX9_0252</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578654.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0252"/>
    <dbReference type="EnsemblBacteria" id="ADW67326">
        <property type="protein sequence ID" value="ADW67326"/>
        <property type="gene ID" value="AciX9_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0252"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_1_0"/>
    <dbReference type="OMA" id="RAMIRHH"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="19163" checksum="6EEFC9A54BF67979" modified="2011-04-05" version="1">MLLNWRLDVQRWALLRLQGVAARRRRGPKVARHLAVGERGEFEAMFYLRRLGYQFVERRWRSPELRGDLDLIGWDGETLCFVEVKARTARDLAPAEASVDEQKKAMLRRMARAYRRTLPREDRKDLALRFDVVSVYLLGQTVECELVRDAFAFVSDEEVGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW48</accession>
    <name>E8WW48_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0282</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578682.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0282"/>
    <dbReference type="EnsemblBacteria" id="ADW67354">
        <property type="protein sequence ID" value="ADW67354"/>
        <property type="gene ID" value="AciX9_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0282"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054561_1_0_0"/>
    <dbReference type="OMA" id="VIYFDPD"/>
    <dbReference type="OrthoDB" id="556766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="413" mass="46258" checksum="666545BBD3A17EB7" modified="2011-04-05" version="1">MTESTSRAACTIVSPNYLAYARTIATSYLAQHPGHRFFVLLVADLADTTAFAAEPYTAVAVNEIGLPDLPAEAMKYDILELNTNVKPTFLKYLIARYSLTRLVYLDPDIFCYAPLTPVFDALETHDAVLTPHITTPVFDGKTPGEQDLLFNGTYNLGFIAVRNTPESLRLLDWWERRCLDLGYSEGRTGLFVDQKWMNLAPGLFEQVKILRHPGCNMAYWNLHERSIAASAPAYAVRGPDGESPLCFFHFSGIVPSDPAVLSKHTDRFTLAQRTDLTQLFADYKAQVLANSGSSLEAIPYGFDTFPDGTTITRLCRRLYAKHQAHFSDNPFIGAWSAYARKQGLVAGKAAPQKATWKDFSSKDRRVEMVHTLLRTALRILGPNRYELLMRYLAHIAVLRNQSVFLNKGLPPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD8</accession>
    <name>E8WWD8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1468</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579841.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1468"/>
    <dbReference type="EnsemblBacteria" id="ADW68521">
        <property type="protein sequence ID" value="ADW68521"/>
        <property type="gene ID" value="AciX9_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1468"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125353_1_0_0"/>
    <dbReference type="OMA" id="YTSHLAM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="16326" checksum="2D7A3BABEA870567" modified="2011-04-05" version="1">MRRVFWDTDVHVYWFEGNLLYIDRIERIYLSMQRRDDRLCGSSYVLGELLVGPLKRNRPDVADRMMGFFTSPRMTLYDYPPEAARVFAMLRADYRLKSLDALHLAIASAAGVNIFLTNDHRLHEVVAPGLPMIATLDSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE6</accession>
    <name>E8WWE6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2585</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2585"/>
    <dbReference type="EnsemblBacteria" id="ADW69610">
        <property type="protein sequence ID" value="ADW69610"/>
        <property type="gene ID" value="AciX9_2585"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2585"/>
    <dbReference type="eggNOG" id="ENOG5032VB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108524_0_0_0"/>
    <dbReference type="OMA" id="HRTNTIP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021455">
        <property type="entry name" value="DUF3106"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11304">
        <property type="entry name" value="DUF3106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="26009" checksum="2EBEF46B66D12BED" modified="2011-04-05" version="1">MKRFSTTRRASAWQRQLPALGLLLAGGFGFAQNRGPAPIVRQPPMMQQRAPMNQQRAFGPGQQNRPHLSEWMQSHSNLPLAQQQRALEMEPGFRQLQPDQQARMHERLTQLNGMTPEQRQRTIARTEAMERLNPDQRQQVRSASQQLGSLPPDRRMAVARAYRSLQNMPEPQRQSYLNSPQIRGQFNDQERGTLNNLLAVPPNLLLQPRRVAPYPATPYPQPYGPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE8</accession>
    <name>E8WWE8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2587</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2587"/>
    <dbReference type="EnsemblBacteria" id="ADW69612">
        <property type="protein sequence ID" value="ADW69612"/>
        <property type="gene ID" value="AciX9_2587"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2587"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596856_0_0_0"/>
    <dbReference type="OMA" id="LARTHEW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="458" mass="49304" checksum="AE79BACD0017AC7C" modified="2011-04-05" version="1">MFYPPIARVAKISGDVEITYRIDSAGQITDVNSVSDPEILRKAAVDQVKSWRFKSDGGVGQRAVVFHFKLTAPDLEDTSGNSTTHVLTTGGEVEVSSGAGSDVSREGCPLPPQRVPTNGQTPRDFVETGWPLLRVEASGKVWWNPPGEWDAPDWNKATKSEIPSQSARALIERFRTEAFWRLCTSYSRNVTETPTNFLRVSLGGLEKDVNVHGIEGLASFDDLFQAIHEATNSHQWRVGDPKTEQMGDMGADVWLPKPGRTKLMASAHFGKLEDVQTALDSGDSVNSHDESGWTPLMYAVGGYQTAKVVEFLLAKGADVQAAGLHGETVLMFAALRGDADQELIAAGARVNARTSRGATALMLLAQKAETDDLKVLLRAGADARMKDSEGLTAADYLMAASCGRSLVSTDTHPWMTVGYGSCNALNADEVLSTASLLRAEGVVATKHWTVAGDLEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG2</accession>
    <name>E8WWG2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2601</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580941.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2601"/>
    <dbReference type="EnsemblBacteria" id="ADW69626">
        <property type="protein sequence ID" value="ADW69626"/>
        <property type="gene ID" value="AciX9_2601"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2601"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_0"/>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="OrthoDB" id="1602061at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="5">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="33404" checksum="8DC75ADF0D8143A1" modified="2011-04-05" version="1">MTQDDDLSPYPTYSDIRVLLCLPLPESEEGPGPLRVFTRVSSLENAQDDSIVFATDESALQQALGSAAGLILAPLASTADENEDRVIRVKDPRLAFARVYQRWFAARPTPGVHASAVVGAEAVIGQGTSVGAGAVVEDGAQVGADCQIGPRVVILAGTTLGDRVKVKAGAVLGSSGFGFARDRSGYIGFPQIGTLVIEDDVEIGANSTIDRGALGETRIERGAKIDNLVHIAHNCRIGQDVIIAAQVGMAGSTTIEDNAMLGGQAGLGEHVTIGRGVILGGQGGVLPGKRIDGEGEIFWGTPAQPVREYLRNLARMRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL6</accession>
    <name>E8WWL6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3761</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582069.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3761"/>
    <dbReference type="EnsemblBacteria" id="ADW70761">
        <property type="protein sequence ID" value="ADW70761"/>
        <property type="gene ID" value="AciX9_3761"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3761"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432707_0_0_0"/>
    <dbReference type="OMA" id="VHPGYLV"/>
    <dbReference type="OrthoDB" id="1639719at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="21309" checksum="97EC34DA128B6631" modified="2011-04-05" version="1">MKLSDKIRYLREVEGSLRGLNRAMTQQELVRAIAEDSASGTISQSYLSQIESGARPHLTNTTRLLLARFFKVHPGYLVEDPEDYQAEFRTAELAQRQSEDKLDLWLIAGAERFGKADPKLCRALLTLAQHEDSRRCLLLMESILETPALIDRLYQVLNPSEAVLAAELQPTKAEKEKKSGKKKRKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR3</accession>
    <name>E8WWR3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="9" type="ordered locus">AciX9_0319</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0319"/>
    <dbReference type="EnsemblBacteria" id="ADW67391">
        <property type="protein sequence ID" value="ADW67391"/>
        <property type="gene ID" value="AciX9_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0319"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_0_0"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="8">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="275"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="365" mass="39747" checksum="DEF34FDCA8564876" modified="2011-04-05" version="1">MNQKDTPAVLPPDLARDDEMNANSDLAQATLSAASASAKAGTERKPRTGRLSEAKRFKIFSGLANRGLAEEVCRFVGVPLGETKMQRFSDGEIYFQLLENVRGADVFVIQPTCFPVDEHLVELLIMMDALKRASAARITVVIPYYGYARQDRKDRPRVAISSKLVADLLTTAGANRALLVDLHAAQIQGFFNIPVDHLFASPVLVGYFRDLNLPDLTVVSPDAGGVERARFFAKKLDVPLAIVDKRRTDINVTEVMNVIGDVRGRTCLILDDIIDTAGTLVKTVDALLAQGAAKVYACASHPVLSGPAVERIANSRLEQLVVTNTIPLREEAQKVEKIKVLSIAGLLGRAIESIHMETSVSTLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY7</accession>
    <name>E8WWY7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lpxD</name>
        <name evidence="8" type="ordered locus">AciX9_1495</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579868.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1495"/>
    <dbReference type="EnsemblBacteria" id="ADW68548">
        <property type="protein sequence ID" value="ADW68548"/>
        <property type="gene ID" value="AciX9_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1495"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_0"/>
    <dbReference type="OMA" id="YKIPHAG"/>
    <dbReference type="OrthoDB" id="1602061at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="7">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="34700" checksum="D3D245DB6A156007" modified="2011-04-05" version="1">MKLSELAASLGATLQGGDGETEITGIAGIEQAGAGQITFVANQRYAGLARTTKASAILVEPGFPEVSAATLRLKDPYLAFAKAIELFYQAPIYAASIHPTAVIAATATIGARAHIGAYVVVEDGVVIGEDAVLHPHVVVYPHVIIGDRFTAHAHAIIREHCRVGDDVILQNGVVIGADGFGFARKPKEAGEPGWYKIVQSGPTVIESDVEVQANACVDRASIGETRVMRGAKIDNLVQVGHGSTVGENSLLCAQVGLAGSTVIGKNVVLAGQVGVAGHCTVGDGAIATAQSGIPNDVAAGKVVSGYPAVDNRQWLRSVAMFNRLPELMRGLRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ8</accession>
    <name>E8WWZ8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2059 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1506</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1506"/>
    <dbReference type="EnsemblBacteria" id="ADW68559">
        <property type="protein sequence ID" value="ADW68559"/>
        <property type="gene ID" value="AciX9_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1506"/>
    <dbReference type="eggNOG" id="COG3184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107918_2_1_0"/>
    <dbReference type="OMA" id="DMVKLYT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018637">
        <property type="entry name" value="DUF2059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09832">
        <property type="entry name" value="DUF2059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230015" description="DUF2059 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2059" evidence="2">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19139" checksum="EE90AA7A2C3B5F9F" modified="2011-04-05" version="1">MKRTAILLSVLLALPFTAHADETSRKAKAQEIVNLLHMDRLMKQMMDGITQQTKAMTAQMAGGTISPAQQAKLDAFQKKVFTLIDAQMGWKAMEPTYIDLYAKTFTEAELDGMVNFYKSPAGISMVDKLPGLTTQAQQLIGQKMVSLQPQLKQLTEDFQKDIASTTPATTKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG2</accession>
    <name>E8WXG2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0423</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578823.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0423"/>
    <dbReference type="EnsemblBacteria" id="ADW67495">
        <property type="protein sequence ID" value="ADW67495"/>
        <property type="gene ID" value="AciX9_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0423"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709331_0_0_0"/>
    <dbReference type="OMA" id="EICRTET"/>
    <dbReference type="OrthoDB" id="1425476at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233467" evidence="2">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="290"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="389" mass="41198" checksum="A29ECED4F80FA819" modified="2011-04-05" version="1">MSRSHSKLPILLAANALALLTLGCASPGPPQPPSLQLPAPATGLAAQRSGDHVILTWNTPTTTTDKQTIRKPITAVICREVVAHPRPGPAIPRPASTPAPCTPVERLPVAPGEYRHVQTLPPALLVDPPQLLIYRIQLQNPQGRFAPPPPQVYAASGSAPPPTGSIHVRPGRDGAVIEWTPLPTTTSMQLHRTLIADVKGPITPPATKKPKTRSPLGGGPAPSTPPNQATLRSPDSPTDPGGLLDPTVKPLDTYTYTAQRIRTVTLGRHTLDLFGEPSAPVTLTNRDTFPPHAPTGLASVAGGGFNSPPSIDLSWEPNTEHDLLGYNLYRAETPAGPFRKLNATPLPGPSYRDLAVEPGHPYLYRVTSIDETGNESSPSATIKDTLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG5</accession>
    <name>E8WXG5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0426</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578826.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0426"/>
    <dbReference type="EnsemblBacteria" id="ADW67498">
        <property type="protein sequence ID" value="ADW67498"/>
        <property type="gene ID" value="AciX9_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0426"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_0"/>
    <dbReference type="OMA" id="CCRNFGT"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="397" mass="43182" checksum="77957FD9874D080C" modified="2011-04-05" version="1">MKAVCWMGKQKIEIQTVKDPEIINPQDAVIRITRTAICGSDLHLYDGYIPTMESGDILGHEFMGIVEEVGSEVKKLKRGDRVVVPFTIACGSCLFCKKDNWSLCDNSNPNAHIAEEMYGYSGSALFGYSHIYGGYAGGQAQYARVPFADVGPIKIENDLPDEKVLFLSDIYPTGYQGAVNANIEPGDTVAVWGCGPVGLFAIASAYMLGAGKVIAIDRYPERLKLAREYCGATTIDYTQDDVIVVEALRDLTGGIGPDSCIDAVGMEAHSNTFVGKYDSVKQAVGLETDRPFVLRQAIQAVRKGGTLSIPGVYGGVLDKVNFGAAFGKGVKMGMGQTDMHKYLAPLLKFVEDGKIDPSFLISHRIGIEQVPDAFKMWRDKEDAVTKIVIDPWQDVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI6</accession>
    <name>E8WXI6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1549"/>
    <dbReference type="EnsemblBacteria" id="ADW68602">
        <property type="protein sequence ID" value="ADW68602"/>
        <property type="gene ID" value="AciX9_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1549"/>
    <dbReference type="eggNOG" id="ENOG50338HZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459365_0_0_0"/>
    <dbReference type="OMA" id="FQHEART"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="185" mass="19541" checksum="462BCB2FB43CD8D1" modified="2011-04-05" version="1">MSVGRDLRLLTMSLLCLVDTGCVFHHKTRIVLPAAPPTQVPLASAPEPAKPPVVAQVPLIPTPVTTVKLPEKKKPKKKKPVIPTAAPTQIASSGVPTPEARDVIGALTAGGDATPEKKLRAADMIGDLEKRLSGLAPTIQDKQKDAIARVRYFQHEARTALDSGDADGAVTLATKAKLLLDDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ5</accession>
    <name>E8WXJ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1558</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579930.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1558"/>
    <dbReference type="EnsemblBacteria" id="ADW68611">
        <property type="protein sequence ID" value="ADW68611"/>
        <property type="gene ID" value="AciX9_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1558"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_6_1_0"/>
    <dbReference type="OMA" id="QTNVWRI"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="45938" checksum="997D170C120952F3" modified="2011-04-05" version="1">MAFWKSWRVRIILFLAVLGPGFITANVDNDAGGIFTYSQAGAAYGYTLLWTMIPITLALIVVQEMCARMGVVTGKGLSDLIREEFGLRMTFVVLMLLVVVNFTNVITEFSGIAGSMSLFHLSKYVSVPVCAVLVWALVVKGDYKKVEKIFLIASVFYIAYIIAGVLSEPNWHAALVETVKLPPRNVWGDKSYVYTTVAVIGTTITPWMQFYLQSSIVEKGVSVKQYKASRLDVIVGSIFTDVVAWFIVVACAATLFTHGIKDIPDASVAAQAMKPLAGDYAFILFAAGLFNASLFAASILPLSTAYTVCEGMGFESGLDKTFKEAPFFYWFYTLLIALGAAVVLIPNFPMLKVAILSQVLNGLLLPVVLIFMLRLINKHELMGKYTNTVWLNVVAWATAIIVIGLSAVMVFNSLKTVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ7</accession>
    <name>E8WXQ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2728</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581067.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2728"/>
    <dbReference type="EnsemblBacteria" id="ADW69752">
        <property type="protein sequence ID" value="ADW69752"/>
        <property type="gene ID" value="AciX9_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2728"/>
    <dbReference type="eggNOG" id="COG4774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_1_0"/>
    <dbReference type="OMA" id="TWGSDQT"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="871" mass="92703" checksum="A9CE17D4B1B31AFE" modified="2011-04-05" version="1">MAEKTGLNSVGNMAVVAMVAAWTAVSAPAVSFAQVPNNGSATTAASQQKSFDIPAGRLPEALEAYKKATGVTVAVKVGNTAGEDFQTSAVTGVYTNEAALRAMLNGTGLSSRFTAGGTAVVSIENAESVDVSAPLPNEVAMTKFTSPLLDTAASVTVIPQFVLKDEGVSTLRDALRNVPGISLAAGESGAQGDNLTIRGFTARNDIFMDGIRDFGSYFRDSFNYEQVEALEGPAGIAFGRGATGGVINQENKVPGVTPLINVQAQFGTNLTRRVTADINEPIPDVANGAAFRLNLMVNDSGVAGRPFDAIHRLGVAPSISFGLNTATRFTLSYIHLNENDTPDYGLPWFYNKLAPGVSRYAYFGFADQNFLKTNDDIITAKVDHDFNSHVTVHSIARAANYPRNAQITEPQICTNASIPAPVGGWVPSRPTSSVTGANCPYIPGAVNPSTILVNRNQIQIKSVEGDLWDQTEVNARFKVLGLKHEFVGGVEGGQEISNPIRYGYTISGLNTVPSTTLVNPNTSQVFGGTGYISSIVHTKAESVGLYFVDTVHLGRLFELSGGVRWDRFDTGYNGYQPTAPTGGTALAASSAGTFSRVDAQPSYRAAFVYKPTSHGSVYFDYGTSFNPSAESLALTSITQNVAPEQNETYEAGAKYSFLNEHLMMEGAWFRTEKDNARETDPNNSNNIVVAGNQAVKGVQVSAVGRLPQGMDIVAGYAYLSSKVLYSPFYPTSVGYQLANVPKQTFNAFITHRLPGHFNAGVGGNYVASRTASSTTPFVPLTFGAATTFAAGSAPCGTATTTTCYQVLSTGMKQVPGYWVFNLMLKRSISEHLEVQANVNNVLNRFFIDLPHPSHLIPGEGANALMGLNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY18</accession>
    <name>E8WY18_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FkbH like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0485</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578885.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0485"/>
    <dbReference type="EnsemblBacteria" id="ADW67557">
        <property type="protein sequence ID" value="ADW67557"/>
        <property type="gene ID" value="AciX9_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0485"/>
    <dbReference type="eggNOG" id="COG3882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018095_1_1_0"/>
    <dbReference type="OMA" id="YECGYGQ"/>
    <dbReference type="OrthoDB" id="1310135at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="599" mass="66745" checksum="CDF6EC7B1EC75058" modified="2011-04-05" version="1">MAQPDGIDLASLSLDDVLMKRKALKRRLSARQNLRPLRLAVLGGSTTNETVELLELWLLEAGFLPFIHQSEYGRFYVDAVHDTDALVEFKPDIVYVHTSAINIERFAPVGCSEREFDEQVQAELGRFREIWKSLEEKLGCLVIQNNFEFPPYAILGNLDAVVSGGHVRFITALNVEFAKAAAANPKLLLQDICCISARLGLDRWFDPERWFSYKIVTSPEGSSALAVSLAAIVRASYGQTRKVLVLDLDNTLWGGVIGDDGVDKIQIGKETPIAEAYTAFQEYCLSLRNRGILLAVCSKNTDEIARQGFEHPDSILKLEHISCFKANWDPKHENIAAIAKELNLGTDSFVFVDDNPAERAIVEAQVQGIAVPNVGSEVSKYAAIIEAGRYFEQISLSREDVERAALYQENTQRAVFETKFSDYGEYLDSLEMSAEIGAFRSVYLDRITQLTNKTNQFNLTTRRYTLAEIEAVLSDPDAIGIYGRLSDRFGDNGLISIVLGHRAGNVLEIDLWLMSCRVLKRDMEVAMLDALVEKARGIGIEKLHGHYIPSKKNAMVEGHYAALGFDLVSRDEAGAALYSLQIAVYVSRNTHIKVVEPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH9</accession>
    <name>E8WYH9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2862</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2862"/>
    <dbReference type="EnsemblBacteria" id="ADW69885">
        <property type="protein sequence ID" value="ADW69885"/>
        <property type="gene ID" value="AciX9_2862"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2862"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_0"/>
    <dbReference type="OMA" id="CNGGFFA"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="34303" checksum="C7104551B91235BB" modified="2011-04-05" version="1">MPTMTATTTLGTGLLERIGNTPLVRLDELTLDMPGVQILGKAEWANPGGSVKDRAASAIVGDAMRRGVLGRRADGSVQGLLDATSGNTGIAYAMLGAALGFPVTLCMPSNVSQERKKYLAAYGAEIVWTNPADGSDGAIRKAREMVAAEPERYFYADQYSNENNWKSHYHTTANEIWKQTEGQITHFVAGLGTSGTFMGTTRRLKELNPEIECISMQPDSAFNGLEGLKHMATAIVPKIYDPALADANIDLETERAYKMCLRLARKSGLLVGVSAGGAVAAALEIAEREYKAGREAVVVTILCDSAEKYMSERFWQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR8</accession>
    <name>E8WYR8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1706</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1706"/>
    <dbReference type="EnsemblBacteria" id="ADW68754">
        <property type="protein sequence ID" value="ADW68754"/>
        <property type="gene ID" value="AciX9_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1706"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="LAEVWDW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="239" mass="27169" checksum="997179319DF0FB7E" modified="2011-04-05" version="1">MEVSRLSQTIFVLEDDADISRLVQYHLESAGFTVRPYAAIQQIVSDAERQPPSLFLLDIMVPGGDGLDLCRRLRLNPTLSVVPIIFLTARAAENDRVQGLELGADDYITKPFATRELVARVKAVLRRFERPTTPSILKFEQIEIDAGAMQLRVKGELVTTTATEFRLLDYLARHPGRVFSRDHLLDAVWGDARFVTPRSVDVYVRRIREKIEEDAETPRYLKTMRGAGYRFEIPKVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT6</accession>
    <name>E8WYT6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1724</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580091.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1724"/>
    <dbReference type="EnsemblBacteria" id="ADW68772">
        <property type="protein sequence ID" value="ADW68772"/>
        <property type="gene ID" value="AciX9_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1724"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_19_3_0"/>
    <dbReference type="OMA" id="LYCVQPM"/>
    <dbReference type="OrthoDB" id="1118058at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="410" mass="43220" checksum="129873C125191FB7" modified="2011-04-05" version="1">MASISRVVSPLEEKTELRGGAGQLLAVFLCGTLAFLDLYCVQPLLPLLSRVMHASESAVGLTISAATLGVAVSAMLLAVFGERLDRKRTIVISMTALALSTLMTSTAHNLVQLAMWRLLEGLLTPGIFIITIAYVTEEWPALQVPRAMSVYVAGTVFGGFVGRVSGGLLGGRVGWRPVFVLLGVLGLCGAAATQWLLRPATMRRVAKKAESIWTPVMRNLRSTRLLATFAIGFCMLFTLVSVFSYITFYLTEAPFLLSTDAISWLFSVYLFGLVATLIAGTVLAKVGLRAGMLAAVGCCLVGVGLTLIHLLPVVALGLAVASSGVFVAQVCANSFLRDAAPAGGRVSAAGMYICSYYIGGTVGGVLPGLVWRMAGWPGCAGLTCGFLVIAGVTAFFGWREKNGWAEPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ3</accession>
    <name>E8WYZ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2885</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581223.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2885"/>
    <dbReference type="EnsemblBacteria" id="ADW69908">
        <property type="protein sequence ID" value="ADW69908"/>
        <property type="gene ID" value="AciX9_2885"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2885"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052035_0_0_0"/>
    <dbReference type="OMA" id="IPSYNNA"/>
    <dbReference type="OrthoDB" id="550571at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="402" mass="42872" checksum="08051800FE53152F" modified="2011-04-05" version="1">MATTQTINEPATSAAGAPSLLVSLASLSHDAFEHLLTNLGAAFPGEAVVVATPDNAVGGDAEANHGGLRVVGYTPSAPSPGSWTLTAADFLNAHELAARYQAPAVLVLGTEAQSLAPSALRGLADSVVSNGCDLAMARYTLPPRAGLVNSAILYPVTRALFAARPRFPLAIDMALSARMAERLATAAQRFTAAGQTDAMVWPISEAAVAGFSIAQVEVGTRTLPAPQGVDLNSVLAQVAGSLFSDVDAKASFWQRARPVQTERIPVIPAATPTGSDEVQGMLDTFRLAYTNLHEIWSLVLPPQSLLGLKRLSVMQPAEFRMSDSLWARIVYDFLLAYRLRTINRGHLLGALTPLYLAWAASHILMTEAGTDPERHIEAVAAAFEADKPYLVSRWRWPDRFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC3</accession>
    <name>E8WZC3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alginate_lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1763</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580130.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1763"/>
    <dbReference type="EnsemblBacteria" id="ADW68811">
        <property type="protein sequence ID" value="ADW68811"/>
        <property type="gene ID" value="AciX9_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1763"/>
    <dbReference type="eggNOG" id="ENOG5033TMW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825770_0_0_0"/>
    <dbReference type="OMA" id="WHYSNFN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_lyase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="37519" checksum="9F1FF67569B32591" modified="2011-04-05" version="1">MPTRRAFCQLAAATLAAPHLRAQTTRPNLREIDHDSIQAAASKALARPVTTGTPDSQAFLDLTLDIPALAAANYLTPDPSYPGAALKHLTPWFVSTKTKLPTLTEHENDILLTAPLAELAVALPFLGLTPPELAEIKLWFAEYLTWLNESRTALLARDSKDHHASSWLLQVAAYAHLTANDAILTENRHRFKSQTIRAQIEATGLFPHELPMPDPFRNSLMNLDLLAGACVLLSTQFDSVWDHELQDGPGMRAAISRHAPYIEHPTTWPYPADQTHFHELPCRRPALLFAARAYSQVPYADLWRTLKPDPTSPEILRAFPIRQPILWLAQPRFVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF0</accession>
    <name>E8WZF0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580157.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1790"/>
    <dbReference type="EnsemblBacteria" id="ADW68838">
        <property type="protein sequence ID" value="ADW68838"/>
        <property type="gene ID" value="AciX9_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1790"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="RSFMYID"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="36433" checksum="0AB59DA6A3BC9175" modified="2011-04-05" version="1">MSLKGERAVVCGAGGFIGGHLVKHLIANGVEVVRAVDIKPLDEWYQTTADVENVAMDLKDKDSCLKAVEGVNTVFQLAADMGGMGFIENNKALCMLSVLTNTHMLMAARDKGVGRFFFSSSACVYNADKQTNPDVVALKEEDAYPAMPEDGYGWEKLFSERMCRHFREDYGLETRVARYHNVYGPEGTWTGGREKAPAAICRKVLQAKMDGTHEIEIWGDGKQTRSFMYVDDCTKGSQMILESDILEPINLGSDELVTINQLVDLAEDIAGVKLTRKYNLSAPKGVNGRNSDNTMILDQLKWEPSTKLRDGLAKTYAWIEEQMLVGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF9</accession>
    <name>E8WZF9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580166.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1799"/>
    <dbReference type="EnsemblBacteria" id="ADW68847">
        <property type="protein sequence ID" value="ADW68847"/>
        <property type="gene ID" value="AciX9_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1799"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1145929_0_0_0"/>
    <dbReference type="OMA" id="RCFIAEP"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="26383" checksum="A1BFE9693237F53F" modified="2011-04-05" version="1">MEQSECEVADRSLVHQSDSLFERCSWFYALCREYLFRDHTQEIVRSLFPVEPPAPGTKLLELGCGPGFYACRLSEELPTLQTTGVDLSVALIERATSRAKSRQLSNCSFQHADAHSLPYPSHSIDAVVVSRLFLIVPDKEGIVREIHRVLRPGGRCFIAEPTSGFRTRLPLAVMWILSRLTTSPAGKDREPQVADVMSRPDFKALVETQPWGSMELEYDGWYQYAVCRKSSTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM6</accession>
    <name>E8WZM6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neprilysin</fullName>
            <ecNumber evidence="11">3.4.24.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2977</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.11" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581314.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2977"/>
    <dbReference type="EnsemblBacteria" id="ADW70000">
        <property type="protein sequence ID" value="ADW70000"/>
        <property type="gene ID" value="AciX9_2977"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2977"/>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_0"/>
    <dbReference type="OMA" id="DQRFFMN"/>
    <dbReference type="OrthoDB" id="305005at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233530" evidence="8">
        <location>
            <begin position="21"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13_N" evidence="10">
        <location>
            <begin position="46"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="9">
        <location>
            <begin position="476"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="681" mass="75547" checksum="A436BD7E419552C2" modified="2011-04-05" version="1">MSLKHLALPALALACTTLSAQAPAAKPTYLPTPSFDIASINPSADPCNDFYKFACGNYAANHPIPADQASTDGFYTLYNVNTEELSGILAKYEKPDPSRTPDQQKIGDFYHACMDTDAIEKSGLTPIAGLLAEIDSMTLRNLPSLAGKLSRINVTVFFGFGEQQDLKDATKQIANIDQGGLGMPEKDYYLRTGAKDEQLRKDYVAHMTKMLTLAGSTPQQALKDATAVMAFETALAKASMGVTERRDPEKTYHLVPISEINKSFPYGLFGQFEDAVHSPRVTEINDANPSYIPAAVALIRDTDLETLRAYIRYHLLTAEAHNLPKSFDQENFDFYGRKLTGSEVQRARWKRCSAAVDGDLGEALGKVYVNQYFAGDSKKKTLEMVTDIEDAMDRDIDQLDWMSPATKTRAKEKLHLVANKIGYPDHFRDYSSVTIKPTDAIGNDMRATQFENDRQLNKIGNPVDHQEWGMTPPTVNAYYNPSMNDINFPAGILQPNFYDPRQDDAVNYGHIGAVIGHELTHGFDDEGKKFDGNGNLSDWWTAEDTKKFEAKTDCEVNEYNQFVAVDDVHVNGKLTLGENTADNGGLLLAYMAYLDRAKKQGVDLAAKKDGYTPIQRFYISFGQNWCANDRPEAIRSQVLTDPHSPDQFRTNGPIVNQPGFAAAFSCKANSPMTPTKSCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW3</accession>
    <name>E8WZW3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0704</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579102.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0704"/>
    <dbReference type="EnsemblBacteria" id="ADW67774">
        <property type="protein sequence ID" value="ADW67774"/>
        <property type="gene ID" value="AciX9_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0704"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065962_0_0_0"/>
    <dbReference type="OMA" id="PRYQMRL"/>
    <dbReference type="OrthoDB" id="1379602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="31150" checksum="587170320BA2C079" modified="2011-04-05" version="1">MISVLILTKNEAQDLPGCLASVVWSDDVHVLDSHSTDATVAIAQAAGAIVTQRPFDNYAAHRNFGFQLPFKYPWLLILDADERPTPELSREMLLQAANAPADVSGFRLRRRDFLFNTWLKHAQLSPFYIRLVRPERSRYTRAINEVLEVEGTIAELHEPLDHFPFSKGIAHWVAKHNQYSTMEAQLIHSQQGLTNPSLRTALRDSDFHTRRLHQKAIFYQLPGRPLIKLVYMLVVRRAILDGSAGVTYAILQSIYEYLIVLKTKELHLNQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX3</accession>
    <name>E8WZX3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0714</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579110.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0714"/>
    <dbReference type="EnsemblBacteria" id="ADW67784">
        <property type="protein sequence ID" value="ADW67784"/>
        <property type="gene ID" value="AciX9_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0714"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106323_0_0_0"/>
    <dbReference type="OMA" id="HAIHIIV"/>
    <dbReference type="OrthoDB" id="1499990at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230120" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="139"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="23163" checksum="541ABEAF48DF1A6A" modified="2011-04-05" version="1">MRFNLLLAAALIAAPAFAQPAPQQPEAGNPNTFAQADQMRIVQQVRHQLLSLPDYAVFDSLSFGIRGRTIILNGFASRPILKDEAQKVVKSIEGVETVENQIKVLPFSNFDDQIRVAVYRRIYSQPALRKYTGSPVGFGAFPSVARAAGGITNDPPLGYHAIHIIVDNGHVILKGVVDSESDATIAYVQANSTPGTFSVENDLVVPNAPPRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X014</accession>
    <name>E8X014_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1864"/>
    <dbReference type="EnsemblBacteria" id="ADW68910">
        <property type="protein sequence ID" value="ADW68910"/>
        <property type="gene ID" value="AciX9_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1864"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_0_1_0"/>
    <dbReference type="OMA" id="NGFDNEY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="39641" checksum="9B8E37CEB67C1CFB" modified="2011-04-05" version="1">MKETLLQGNISDLAPTSLQEDVAKSVFDVSIIIVSFNTQAILRECLESVFREAHPFRAEVFVVDNASMDGSAEMVERQFPAVRLIRSEVNLGFGGANNLALKQARGRFFVLLNSDAFFAPGALALALEHMEETPDCALGGCLLVGRDGSSQPSSRCFHTVIGDAIVLTGLAAKFPKSRILGRFDRTWADESVPSKVDWVPGAFSIVRPEALRQVGLFDPDFFLYYEEVDLCLRMKRAGLKVWYWPDVVVTHVGGESSRQLKSMDYSSPASQVVKWRMRSTLLYYRKHHGSKALLAKWLEKTLYWFTILRNRWSGEPWRQRRANYNRSLIRLMDEAWKDTQGGRVSPARPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X044</accession>
    <name>E8X044_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GumN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1894</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580259.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1894"/>
    <dbReference type="EnsemblBacteria" id="ADW68940">
        <property type="protein sequence ID" value="ADW68940"/>
        <property type="gene ID" value="AciX9_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1894"/>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057525_0_1_0"/>
    <dbReference type="OMA" id="VYLELDM"/>
    <dbReference type="OrthoDB" id="1991552at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230125" evidence="1">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="33186" checksum="B91482723D43EBA4" modified="2011-04-05" version="1">MFKGFVCAGLVLVAGQVGAQVAPSAAPAAAPAVVAPAAVKANPAMWKVQGEHETVYLFGTVHVMKPGVVWQTPKVAEAFKKSDTLYVEVAKVDDPASMQPLVMELGMDKDHPLSTVISKEDVALLDAAVKGMGFPGEVAMEPMKPWLAYMTLSVLPMLKAGYDPASGVDVKLTGDAKDSSKKIVGFETADQQLHYFADFPVPEQVALLHQELIDLPKSGAQMEEIIGSWERGDVDKIGEMENGEFRAKYPELYKKLVVERNARFADELATLLKSDKPGVAFVAIGAAHLAGPDSVQHDLEAKGFKAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B5</accession>
    <name>E8X0B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3076</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581410.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3076"/>
    <dbReference type="EnsemblBacteria" id="ADW70096">
        <property type="protein sequence ID" value="ADW70096"/>
        <property type="gene ID" value="AciX9_3076"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3076"/>
    <dbReference type="eggNOG" id="ENOG5030PX5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265454_0_0_0"/>
    <dbReference type="OMA" id="HFGTETR"/>
    <dbReference type="OrthoDB" id="1591801at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233552" evidence="1">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="23392" checksum="F391CC1252B75510" modified="2011-04-05" version="1">MQRSMKALACLFAAAVTTLAATAAQAQSQSKLAAAAPVTYDNKYEVYGGINFMNFQAGQDIPKRMNLGGIEVAGTYWLTHKLGLTAEYRGEAGTTPVIPTARNVNTTVQPLVVLHSGLFGVQYRGPKSQRAAINYHAYGGAAYGDFTESGIVNNGPQSAGLYDNHTAPIFALGGSVDFNRSKNFAIRLSPDLILEHFGTETREFFAISGGVIYRFGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F9</accession>
    <name>E8X0F9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ordered locus">AciX9_0753</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579149.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0753"/>
    <dbReference type="EnsemblBacteria" id="ADW67823">
        <property type="protein sequence ID" value="ADW67823"/>
        <property type="gene ID" value="AciX9_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0753"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_0"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="114"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="232"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW67823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="389" mass="41598" checksum="5D65DDE955E38A0A" modified="2011-04-05" version="1">MAKRDRFLFTSESVTEGHPDKIADQISDAILDACLEQDPMSRVACETLTCTGLVVIAGEITTKAYVDFQGLVRSTIAEIGYTHSSYGFDSNTCAVISTINKQSPDIAQGVDTGGAGDQGMMFGYATNETPELMPLPISLAHRLAEKLTAVRKSGLMPYLRPDGKSQVTIEYAEVGKPARVDAVVISTQHDEDVTNEQLRAEIQKNVIEAVIPAELLDSNTKFHINPTGRFVIGGPMGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDSTKVDRSAAYMARYVAKNIVAAGLADRCEVQLAYAIGVAEPVSVLVDTFGTGTVEADKLTELVRANFNLTPKGIIETLKLRRPIFKQTAAYGHFGREGADFTWEQTDKAAALKAGVAEAVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J1</accession>
    <name>E8X0J1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0786</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579181.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0786"/>
    <dbReference type="EnsemblBacteria" id="ADW67855">
        <property type="protein sequence ID" value="ADW67855"/>
        <property type="gene ID" value="AciX9_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0786"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="NHLRVIC"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="35194" checksum="52A6BE246E1CE344" modified="2011-04-05" version="1">MPSAIHTQDLAKGYGRTQALHPLTLDVPAGAVFALVGHNGAGKTTLIKLLMNMIHPTSGTATILGRDTATLTGEDFTRIAYASENQELPDWMTVGQFLSYLKGFYPTWDDAALVQQLELPLDRKLKHLSRGMLMKAALASILAFKPSIILLDEPFSGLDPLVRDELIEALMVRVRPRSLAGSEALSAVPDADRPTILISSHDLAEVESFATHIGFLHQGRLLFAEEMTTLTSRFREITLTLPPPAPGEPTITLPTATGVPDSWLLLEQTLTAARFVHTHADTESIPAQVAAVFPTPYAPDIQVAPMTLRAIFLALAKSGRAPAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U8</accession>
    <name>E8X0U8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3116</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581446.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3116"/>
    <dbReference type="EnsemblBacteria" id="ADW70132">
        <property type="protein sequence ID" value="ADW70132"/>
        <property type="gene ID" value="AciX9_3116"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3116"/>
    <dbReference type="eggNOG" id="ENOG5033KMD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153796_0_0_0"/>
    <dbReference type="OMA" id="HERFAKL"/>
    <dbReference type="OrthoDB" id="1574510at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15641" checksum="C1976C45E9708114" modified="2011-04-05" version="1">MDTILRILKTAGGWNHGLHLHIENPPYMALVIEAVDESGPCGLPALSVCHYGEQNGDAMRDPEMCFELGLAGGAHLNPYYWRNDYVAVEQWSRFIQCGMYVHNSELHDQHEKFAKLWNKNLREQRFLEAFERQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X100</accession>
    <name>E8X100_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0798</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579191.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0798"/>
    <dbReference type="EnsemblBacteria" id="ADW67866">
        <property type="protein sequence ID" value="ADW67866"/>
        <property type="gene ID" value="AciX9_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0798"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036186_0_0_0"/>
    <dbReference type="OMA" id="WITTHAG"/>
    <dbReference type="OrthoDB" id="1536506at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="44775" checksum="A478454DE6D11F25" modified="2011-04-05" version="1">MSFDNFPPHFRLLLLAVRVPLTSADAERLRRIAANDIDWRAFLAAAHSHRLSPLALCGLQSAALSAVPDFVFRELQSSQQASAMRAVKITLETQRIVNHFAASGFTLICLKGITLSQTIYGDPYLRHSGDLDLLTEERDLPGQLLRMRELGYELVDPACAASPRRLRLYIRYQKDLSLCHVQSGRMVDLHWRLFNNRLHKANRLGMTAPINPGQSINASFRTLSRLDQFVYCAAHGSADAWVYFKGLADIAALLHVLSPEELTQALIRTATLGLLPQVSSAIHLAAEFMGARVQHPLLLSPGDSFHQAMRSKVIRNLERSAFTPRRHNPGLFAAMRIELQLTPGLRSMREVIRRYLWRPRIWSIVNLPDALLWLTPLLGLVIPPRVARAPSGPSPPAHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X161</accession>
    <name>E8X161_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0859"/>
    <dbReference type="EnsemblBacteria" id="ADW67927">
        <property type="protein sequence ID" value="ADW67927"/>
        <property type="gene ID" value="AciX9_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0859"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_0"/>
    <dbReference type="OMA" id="AWARQPF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="2"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="483" mass="51539" checksum="54D5858741143D2C" modified="2011-04-05" version="1">MMATMERSQVHVSDKASDEAWLVQALWSARPLRERLSVLRAGRLGLARKTDALVSAISTELARTRADSMVAEVLPLLAACRFLEREAGEILKTRRLGRRGLPFWLAGVESSVERVALGRVLVIGPENYPLFLPGVQVLQALAAGNAVVWKPGAGGRDVAEIFADVMERAGLPDGLLTVTDESVEAGVSAMRGGVDKVFFTGSGASGRAVMRAAAETATPVVAELSGCDAVIVLPSANVERVVAALLFGMRLNGSATCMAPRRLMLVGGGHERLVARLTDAFAAMDGVVVRDSVREQLRGLVEEAKSAGAVVHGDVRDVFMKPLLVTRARPEMQLAQTDVFAPVLTVMEFGDVGAMLEADRACPFGLTAAVFGDEVEATRVGARMKVGTLLINDLIVPTADPRVPFGGRRGSGFGVTRGAEGLLEMTAVKTVLVRRGKGLRQYVPTTDTHENLFGGVIEMEHGDGLRAKIKGLRRMIQAAMRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X189</accession>
    <name>E8X189_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69043">
        <property type="protein sequence ID" value="ADW69043"/>
        <property type="gene ID" value="AciX9_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1998"/>
    <dbReference type="HOGENOM" id="CLU_3025929_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="55" mass="6299" checksum="488DF2F74C31211D" modified="2011-04-05" version="1">MFWETLKLLVYSISGIWVLCYLLSMMMTTGGVASHAETETRIDPIEVFDEELSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B6</accession>
    <name>E8X1B6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZnF_CHCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2025</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580387.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2025"/>
    <dbReference type="EnsemblBacteria" id="ADW69070">
        <property type="protein sequence ID" value="ADW69070"/>
        <property type="gene ID" value="AciX9_2025"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2025"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675728_0_0_0"/>
    <dbReference type="OrthoDB" id="698898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="45120" checksum="BEFD2E9625C8E7C7" modified="2011-04-05" version="1">MSNILHANGILHFQLPKSLFSKSGVFNRGRLNFPALAVYTYLCYKAQEGTKVQMLLTANELGDALKMDADTVQIARGRLEQEGLVSVMRTPLGYTYQLLDHSTGKALVRGIKGDIAPINLDDVSPTGLKTYFRHHTEGPFKSKTGSLTVYCPVHNDSRPSLTVDLNDHGTWKCHACDRGGKLIAFEQWVAKSKGEDLSTKDALPRLIGVLISLGLLKGHLGQPEASYQYRNTAGILKFEVLRYKTNEGKLFLQRRPDPNNPKKWIWNLDGVTKMLYGLGDVDEADVVVICEGEKDCDNVRSLRLTSEITSLKDVAVVTCPGGAHKWQASYSHSLQGKRVIILPDNDKDKTGVTHAQKVVASLKDQALEVRVCCIPSEFKDVSEFLEIHGSDLTQILGSDWIHKPLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E3</accession>
    <name>E8X1E3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cellulose synthase catalytic subunit [UDP-forming]</fullName>
            <ecNumber evidence="5">2.4.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2052</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[(1-&gt;4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-beta-D-glucosyl](n+1) + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:19929"/>
            <dbReference type="Rhea" id="RHEA-COMP:10033"/>
            <dbReference type="Rhea" id="RHEA-COMP:10034"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.12" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580414.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2052"/>
    <dbReference type="EnsemblBacteria" id="ADW69097">
        <property type="protein sequence ID" value="ADW69097"/>
        <property type="gene ID" value="AciX9_2052"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2052"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003556_2_0_0"/>
    <dbReference type="OMA" id="NGWNTAY"/>
    <dbReference type="OrthoDB" id="12414at2"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003919">
        <property type="entry name" value="Cell_synth_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018513">
        <property type="entry name" value="Cell_synthase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03170">
        <property type="entry name" value="BcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01439">
        <property type="entry name" value="CELLSNTHASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03030">
        <property type="entry name" value="CelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="156"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="8">
        <location>
            <begin position="580"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1516" mass="168059" checksum="B30C359CDE7B8D98" modified="2011-04-05" version="1">MTRSPLWREFESGDSFLLKALRFCILFGGICFLIFTGVLELTWPQQAVLGLLTVLLAIWMDRSSSSYLITLTLMLISMYATFRYGFWRVSQVIKFFLDPGNTQWTALDAFFIWLLVGAEAYAFVILFLGYLQTLWPLRRTPVPLPEDPDNWPAVDLLIPTYNEPLSVVRFTALAAMNIDWPADKLNVYILDDGKREEFRQFAQDAGVGYMTRDDNKFAKAGNINRALERLDAPFVAIFDSDHVPTRSFMQVTMGWFLRDRKLGMLQTPHHFYSPDPFERNLDQFRVIPNEGELFYGVVQDGNDFWNATFFCGSCAVLRRTALDEIGGIAVETVTEDAHTSLRMQMNGWNTAYINIPQAAGLATERLSGHVKQRIRWARGMVQILRIENPLFVGGLTIWQRLCYFNAMTHFLYALPRLIFLTAPLIYLIFGHTNVPGYWAAILAYAFPHLMLSSLTNSRIQGQHRHSFWNEIYETVLAPYIFLPTMLALINPKLGSFNVTAKGGVVNKSFFDSRIALPFLVLLGFNVFGVLMAIPRYFHIPYLERVWDGTHPGTIIMNLIWTFFNITILGVATAVAWESQQRRSTVRVAMSVPADVVLADGTIIQGVTADLSSGGVMVTTDRSFTALPGESVKLIFPVLDGDASLPGTIVSADGRSIRAQFDPLNLQEEEALTMVLYSRADTWLGWGEAREADRPLFSLLRIFQLSYHGLSQTIRGLMRNKKSTPKGKFATNVAPLLLFALLAGFSGRHASAQVQSSRYMGVPNSTSATAEVPRPATFGPGAPAPKPVAPGAFDNTFQLADVGVPDTIVLRGVDAYHSVFFSLPQTQVVKTAKMHLRYHFSPGLIPDISHLNVSLNGTLFATLPVKTRPDYVNPNSDLTPSQKVAEQQVLNVTRNENNALLEADLVLPADMLVHSNELTFEFIGHYTFQCEDPSHTTLWSHVDASSTIELAGALLPLSNDLKLLPLPFYDAAVNLHPSIPIVFLSQPSPKALRAAGIVASYFGILTNDHPVRFPVSVGTIPAGNAIVIGESASELPPSLSVNSSSGPTIAMRTNPNDLYAKVLILTGDNADDLVSAAEGLVLQHDMLESDQQRVSFNPKSLADRKPDDAPRWLSTEKNTTLGDITNGGELQGDGSVPVGVYLRVPPDLFYGAQQNLGFHMGYRYNGIPLANESSLQVYMNGAYVSSTPMPHTDKATAVEETIVPIPVIGDMRPFSNSMMMRFVFQIAKKGKCQDTAPLNLQGVIMKDSYLDIKDIPHWAILPNLEIFANAGYPFTRKADLADTAVVLPDTPSVDEVEMFLTFMGHFGAQTGYPVLNVTVTNNDGMKSDHIKDYLVMGTVEDQPALTRLDPLLPVRVDGGGLHIQDTQGFFSPLQHAWWKVRSSDHIQSGQLETAGGLPDALIEGIEWPAGSGKSVVLIALRDHTVVPNFLTVFLKTSQSSDVSQSVSVLHGTKFSSYRIGNDVYRVGSLSLWIRLNLWFSQYSWLDILMVLVICFLMAALIRATLRRRARTRLQGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F1</accession>
    <name>E8X1F1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TrwB_AAD_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3175</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581498.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3175"/>
    <dbReference type="EnsemblBacteria" id="ADW70186">
        <property type="protein sequence ID" value="ADW70186"/>
        <property type="gene ID" value="AciX9_3175"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3175"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405395_0_0_0"/>
    <dbReference type="OMA" id="FITWRED"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TrwB_AAD_bind" evidence="2">
        <location>
            <begin position="225"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="685" mass="76662" checksum="3BB592ED03F4D6DA" modified="2011-04-05" version="1">MNSNQQWGRKETIVWPPHAPVYTFSALALGVFATLFFVWQFLRFTETPLRRTYTPTYIQSLIGATFKQHGKYRLLYVGGGKAAPRLALPADFVPGETRLPNGAVFPVELSEATRQQGYTVLYRGPEKDYNDAALSRWLRSVYFDGQGLLDIYATSLGEGLLVLVIALAFAGRADVKRFRELKYGRHLKGPVMVSPSEFNKALKADGLAIETSKKPWYLRKPIQLRIPKSAEAKHIQIMGDTGTGKSTLIKQLLQQVADRGEIAIVYDPAGEFTESFYKESRKDLILNPLDARAPYWTPSSELRNPAEARTIAASMYQPREEKRGEFFTDTPQKIFAHLLKYKPSPEELVAWMSNEDEIDRRLKGTELANFAPKDAPQQRSGVLGSLGLVADSLRLLPTFEEAQGREWCATEWADKREGWIFLTSTEAEQEALRPLHSLWIDLLVLRLLTRPKPGQKKVWLVIDELASLQRLPQFHTALTKGRKSDNPIVFGYQGKAQLETIYGHLAEVMLSQPTTKFILRTAEPNAAKWAAEMIGEVEIERVRETVADGKRQGKSFTLDRQIEPLVMKSEVEGLPDLHTFVKINNYVSRFSFPPMSLPKIAEALVPRVIPQHKMWFNPLAPVPAATVAGLQAPPSVVEPAISPEATAPRNGAPIKEAEALVPKLELPKAVAPSPQVQTSSISHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G5</accession>
    <name>E8X1G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV secretion/conjugal transfer ATPase, VirB4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3189</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbE/VirB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581512.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3189"/>
    <dbReference type="EnsemblBacteria" id="ADW70200">
        <property type="protein sequence ID" value="ADW70200"/>
        <property type="gene ID" value="AciX9_3189"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3189"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355547_0_0_0"/>
    <dbReference type="OMA" id="MFMDEFW"/>
    <dbReference type="OrthoDB" id="182908at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018145">
        <property type="entry name" value="CagE_TrbE_VirB_cntrl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03135">
        <property type="entry name" value="CagE_TrbE_VirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CagE_TrbE_VirB" evidence="2">
        <location>
            <begin position="312"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="636"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="788" mass="88859" checksum="747DAA9D2E1EC8F2" modified="2011-04-05" version="1">MTRAKTEQLQSVPWFAKAGAACSILPLSRFVSDHIFAIKSGGYGCLFELTGMDEECLTNQELDSHLRTIEGALRSMPEGACLYQYSRVMSGFVIPKQEEYPHLMTHVMVNERIRFLEQEAGFRRMDLHWCLTIEPSKSQGFERTPKQQEFATTRMLVELEKTATLLAGNLSSLLGLKLVTKQATFQFFSYLFNLEDWAEQDVLRADEGLDRQIVKSPVHWESDHLRIGKRFVQMFSLKTTPEASRPCLFSDVAKLDCDSILCTTWRPKSTTAARGEIDRQEKFIEFFKVGVLTRVMSGRDVASLDRGAGAKAASTQVDDLGEVIRSLDKKAQGEYSLRLLVAARTRNDLLAIAPAVHRVFVESRSQVMEETLGNLSAFYAMFPGNAKFNVFPMWLAEDHNARLASVFAPSLGHPHSEDLDKEYLNVFETRTGTPFFQDAYVDGVRVQLIIGPTGSGKSVHGNMAIAHEQKYNGFTYIFDIGGSYESVVELYGGRVDKVGKDGPRVNPFTLEPTESNIQFLYSFVKLLLVNGGAELEPEDDDVIHKAVQDMYLLDACNRRLSNLYLPKQLGRYLAKWIGRGVYANIFDNVEDGLSLSRIQCFDFQGINQHYGDLIEPLMVYLLRRINDVLFNPANLGVPKHILIEELFSSMKNKQLLDAALASIKTVRKNLGGVTMIGQTAEDLGANADSIVNSCTSFLFLKDATFNRKRYAELFKMNEQQLALFESLQDREGLYMRRDGLTKVIRLNLDKRSYATFSTKPKDRVRRSKLIAKYGLAEGIARFAQGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L7</accession>
    <name>E8X1L7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581564.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3241"/>
    <dbReference type="EnsemblBacteria" id="ADW70252">
        <property type="protein sequence ID" value="ADW70252"/>
        <property type="gene ID" value="AciX9_3241"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3241"/>
    <dbReference type="eggNOG" id="ENOG5032REM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715578_0_0_0"/>
    <dbReference type="OMA" id="AMYNGQL"/>
    <dbReference type="OrthoDB" id="1319813at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="466" mass="48859" checksum="C3ED933880E70CCB" modified="2011-04-05" version="1">MSFDNVNDQTEQKPTAFCQNCGKPLDPSTMRVVGPAIYCEPCLAAKLGIGGAVPPPSSGTAPGSAAGQGAGYSYTSTVYTPVGGTTSWAVPPYTRSTPNPGLAALLGFIPGVGAMYNEQYAKGIVHLLVFAMLISLSHATDLFGLIAAGWIAYMVIEAHHTARARRDGTPLPNPFGLNDLSERLGFGKNWGAPSAPGTGAWPNPPAPAPQPVPTAASEVPVETAPPVSNWGAPIDAAPPAWHAEVEQAKRDVPYANSIGSQFGSASYNQGYAANAGYYPPVQPVPPVPPYGVPYSPVAGGDPLAAPGLIRKNRFPAGAVWLIGLGIVFLLATTGIFEGMFGESLVGFGLIALAVWIFIKRMLDSGYGLTSDGSANYPLRVMRALRPSSWLFLIGFLIVLDRLHVVYWVHSWPWLVVLAGLMMLIERFAYNSAAAASQYAAMPPAPAAYAGTSIVPTATNDQHEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T3</accession>
    <name>E8X1T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0935</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0935"/>
    <dbReference type="EnsemblBacteria" id="ADW68002">
        <property type="protein sequence ID" value="ADW68002"/>
        <property type="gene ID" value="AciX9_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0935"/>
    <dbReference type="HOGENOM" id="CLU_818271_0_0_0"/>
    <dbReference type="OrthoDB" id="919706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="38173" checksum="1E28A014503E2EB7" modified="2011-04-05" version="1">MLPKFSAWQALRAESLSFIPLETKIYFKGALPLRKWREAGSYVVVSSDSKKIVLRASRAEVGNAFFTDVEFLLDHAAEHQATLYAAIEEASWCSPAWSFVTAYYWSFFSVLALTRLAGDSTWFLDKTALIAMEKLAQTSSGRPGAGTQFMTVSLDLNGDAEVTIRPSGKNNHEAVWNRAMLLSKRVLASANKASSLDEYRFWKCIVEAGFLLGEAWPSHLRNDVNYIPGYAYGEVRSVGIIKTAADVRRLKDMSFRDFLNDFESELYRITSGVAALTSPEYLVKLALLNAFAVSLVANSLHKDILSRVDGDFRWSRMRQRFLEQRVSTSFGNIWPFEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V8</accession>
    <name>E8X1V8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">AciX9_2074</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580436.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2074"/>
    <dbReference type="EnsemblBacteria" id="ADW69119">
        <property type="protein sequence ID" value="ADW69119"/>
        <property type="gene ID" value="AciX9_2074"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2074"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146668_1_0_0"/>
    <dbReference type="OMA" id="WVPMLAF"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="15936" checksum="982879EE57870202" modified="2011-04-05" version="1">MIVLDANLLLYAYTARSSFHQPARSYLDHIFSDTSESIGIPIQCATAFLRLITNPAVTGARIAMDDAIARVEEWQALPHVRILYPGEEHWQFLKTVTRNGHATGDLIADAAIAAFALEYGAVVHSNDRDFARFSSIRWHNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z3</accession>
    <name>E8X1Z3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2110</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2110"/>
    <dbReference type="EnsemblBacteria" id="ADW69154">
        <property type="protein sequence ID" value="ADW69154"/>
        <property type="gene ID" value="AciX9_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2110"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_0"/>
    <dbReference type="OMA" id="YYQIRAP"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230171" evidence="2">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="57"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="358" mass="37996" checksum="8594CB8E13C9727E" modified="2011-04-05" version="1">MQTPRLRILIATLTLSLTACKSAPPAAPPAMQAMPVAVAPVALNPVPTGDTYVSTIKSRRTANIQPQVDGNITRIFVVSGQSVAAGQMLMQIDPLKQRAAVDQQIGSQAQFNATYQFNQAEVERQRKLFEAGITSRQAYDTAVQNFQNSKGAYQAAAAGTSTQKEQLAYYQIRAPFAGIIGDIPVHQGDYVSPTTALTTLDENKDLEAYIYIPTERAAQIHPGLPVQIVDANGTILERSTISFVSPQVDNGIQGILAKATIPAGSKLRNQQVVNARVIWTSAPQPTVPVLAVTMIGGQPFVYIAKAQGAGFIAHQVPVTLGETVGNSYPVTSGLNPGDRVVVSGLQFLAEGAPIKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X229</accession>
    <name>E8X229_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581584.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3261"/>
    <dbReference type="EnsemblBacteria" id="ADW70272">
        <property type="protein sequence ID" value="ADW70272"/>
        <property type="gene ID" value="AciX9_3261"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3261"/>
    <dbReference type="eggNOG" id="COG3905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2329813_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="11015" checksum="DC565A50E5DFAF43" modified="2011-04-05" version="1">MAINLPAELEQSVDQLAARHGFTKDDFIRDAVEQRVAQYEEEPELTEAQLAHLDEGVAQLRRGEFVPGEVIEAKLEKLLEELEARAKIEEQSASVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D9</accession>
    <name>E8X2D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1005</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579394.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1005"/>
    <dbReference type="EnsemblBacteria" id="ADW68071">
        <property type="protein sequence ID" value="ADW68071"/>
        <property type="gene ID" value="AciX9_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1005"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404280_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="680" mass="77406" checksum="A9E40DA5F9468CCC" modified="2011-04-05" version="1">MNKTLWAVDGELDEAKFERLCVDLLQRQGFTDIVPIEPQDGGRDAEEVPRRGSSREGHPTFFQFSKEGNWKAKLRRDARKLSTRKTEFDTFVFVTSRKARGVDVDALKTEFRNQYGWTLIVFGREWLRLQLEEVNPDIAVKYLGPDVLNRYLGPNAIVLLTEGGGLSLKEISQLIDGEQTEAAILQLRRVLEETPDRSEALQLLAWAYYKSHRYEEALAEINRAIRRVDKPEYRSIRACILTERGIREGDRSSVVAARQIFEELLSSGPIHTWHIFYNLGNVLGELGDHDAAIARYKLAIELDENQPVIWKNLASAYHHVGQHTQEMECFDKALALDPKQPEALISKATSLILDFDKPEEAVPLLELAFRMNPETLVRWPHVCYWLALGYERLNRLEEALDSVDQGLAQRPGDFATRRLKSHLLIKLAQHDPAFRDRALSFWTLELKAEPLNFDARHHLIREALASQDQDSAWNLIDSSFLALDITDTISLRSSTFITGSCVSALRYLPEYANFRRLQPVSEYWDVGEPPCELPFAPPIDDIVEAAFKTYFLVPFASGWKHLKTVKDPNQPEALGTLFDLVRDELRIATSQAVRSLARIVPGKETGTEALAVKMTEIMVFAAHTSLREFGKQRGYIMGCFAVSPDACEIALESYDEVRLHTDVLTDTLKVLNEELKIMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F8</accession>
    <name>E8X2F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione synthase/ribosomal protein S6 modification glutaminyl transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2138</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580498.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2138"/>
    <dbReference type="EnsemblBacteria" id="ADW69182">
        <property type="protein sequence ID" value="ADW69182"/>
        <property type="gene ID" value="AciX9_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2138"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048863_0_0_0"/>
    <dbReference type="OMA" id="INNPFWW"/>
    <dbReference type="OrthoDB" id="407111at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="92"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="39107" checksum="6806B3EE835AE4B8" modified="2011-04-05" version="1">MKKIGVLFGMENTFPGALVERINSMQVDDISAEFVQVGGVKMDEPSPYAVIVDRISHDMPFYRGYLKNAALHGTHIINNPFWWSADDKFFNYALAAKLGVAVPKTVLLPHKHYPPDINQQSVRNLEFPLDWPGIFEYIGFPAFLKPHDGGGWKDVWHVHNPDEFFHAYDQSRDLCMTLQAAVKFKEYFRCYVVGRNDVKIMPYDPSRPNAERYVMDPPEYDPKLLARVEKDALTLCRALGYDLNTVEFAVEDGIPYAIDFMNPAPDADYHSVGPDNFEWIVDKMARLAIAKAQQGVASGSDLNYAAFLNGTPSSGSAKVSAKKTAIKKSVPAVVKKVAAKKVAAKKNATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L9</accession>
    <name>E8X2L9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2199</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580559.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2199"/>
    <dbReference type="EnsemblBacteria" id="ADW69243">
        <property type="protein sequence ID" value="ADW69243"/>
        <property type="gene ID" value="AciX9_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2199"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125957_1_0_0"/>
    <dbReference type="OMA" id="FNHGFTR"/>
    <dbReference type="OrthoDB" id="2012318at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15968" checksum="CC6D95A9ED546AE3" modified="2011-04-05" version="1">MRVAGKELAYGLLRVALGLNFLGHGGFRILSGVGAFAVGMAEHMTKSPLPHGMVVGFGYAIPWIELLLGLGLILGVFTRTVLVGGALFMMALTFGTTSNQQWDVAGQQLVYSVVFFGLLYLVEFNRFSIDWLRAPDGLRGGMARSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N0</accession>
    <name>E8X2N0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3316</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3316"/>
    <dbReference type="EnsemblBacteria" id="ADW70327">
        <property type="protein sequence ID" value="ADW70327"/>
        <property type="gene ID" value="AciX9_3316"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3316"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277670_0_0_0"/>
    <dbReference type="OMA" id="TSQAYHK"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="6">
        <location>
            <begin position="401"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1218" mass="131545" checksum="562744A38A492807" modified="2011-04-05" version="1">MAFCYSWAVIPPWMLPWANEITREVLVSSFRLNPLFTTSAVIAFLSVMPGALAQTTPAPDITKQPTLYVVPYAHLDTQWRWEFPQVISEYLLKTMRVNFDYMDKYPHYVFNWSGSNRYRLMKEYFPADYARLKGYVAKGQWFPAGSSVEEGDVNLPSAESIFRQVLYGNTFYRSEFGKASAEYMLPDCFGFPASLPTILAASGVKGFSTQKLNAAWQPAPKIGGPNSPEKTPEGIPFNVGLWTGPDGETVLAALNPGSYNGGINSDLSKSPTQVPAPVASNGRRRRTEVDWPSRIDIDGKATGVFADYHYVGTGDIGGAANEESIKLLEAMVTGGEAVIPATPVSASGGAAGEIVTAGTPVRMGNGPVKVISATADQMFLDIKPEMQSRMPNYQGDLELINHSAGSLTSQAYHKGWNRKNELLADAAEKASVAAAWMGGRAYPQKQLNDAWTLVMGGQFHDTGAGTATPRSYEFAQNDDVIAANQFGDVLTSATQSIASSLDTQVTGTPVLVYNPLNLEREDVVEAMVAGDFSKGVAVFGSDGKQVPAQVQNGKILFLAKVPSVGYAVYDVRHGQKPASSQALNVTESGLENARYKVTINAAGDVSSIFDKSIQKELLASPMRLAINNDAPKQWPAWNMDFDQEQAAPRAYIGGSVKARIVENGPARVALEVTREGEGSKFVQTVRLSAGDAGNRVEFSESIDWRSLSANVKAVFPLTSANKLATYNWEVGTIQRPAAFDRQFEVASHHWIDQTDTSGSYGATILTGVKNGSDKRDDSTLRLTLLRSPGEASEMKGGYADQFNQDWGHHEIVFGLAGHAGDWRQAHTDWHAYRLSTPLIAFNTEKHAGPLGHSFSLLTVNNPAIRVLALKKSELSDEVIVRLVELDGKAADKVAVKFSGPLQAAREVNGQELPLGAASVVDGALETSFKPYQPRTFALKLGAPAAHGTSIASQPVALQYDLAVASNDDTKTSGGFDKQGDAIPAEMLPSELTLDGVRFALAPAATGKPNAVIAKGQSVELPKGKFNKVYILAASAGGDQTATFKVGKTPTSLTVEDWGGFIGQWDTRVWKPRPDSVMEGGGTNEPAEHPVPLRNDFATSANHPTWDVKKSGSPDWAPDFPKDYVGLRPGFIKPATLAWYASHHHNAEGLNVPYQYSYLFVYALDLAPDAKTITLPQNASLRIMGISVAETEPNVTPAQPLFDTLGRTTNDGKLEAFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R3</accession>
    <name>E8X2R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3352</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581672.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3352"/>
    <dbReference type="EnsemblBacteria" id="ADW70360">
        <property type="protein sequence ID" value="ADW70360"/>
        <property type="gene ID" value="AciX9_3352"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3352"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165352_0_0_0"/>
    <dbReference type="OMA" id="WALIETW"/>
    <dbReference type="OrthoDB" id="1691345at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25626" checksum="F46EB997F5CE3A61" modified="2011-04-05" version="1">MNHIPYFTEIEDRFQQRRGSILMLSTLDWALIETWHDAGIPLEAVLRGIDEAFDKYETRKLRTKGRLQKINGLAWAAQSVMQSAELSAEAAIGLAPRKESPESGFETEPVAAYLEANAQTIEASGIAGETATRLRELAADLRINPTQHLEDLDRTLTVLEEKMLAAILAATPEDDLVALREQAARELAPYRGKMQAVQIKQVQQQFLQKRLLEACNLPRLSLFYMPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S9</accession>
    <name>E8X2S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3368</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581688.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3368"/>
    <dbReference type="EnsemblBacteria" id="ADW70376">
        <property type="protein sequence ID" value="ADW70376"/>
        <property type="gene ID" value="AciX9_3368"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3368"/>
    <dbReference type="HOGENOM" id="CLU_1523076_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="19890" checksum="CAE7D7D02381C876" modified="2011-04-05" version="1">MSGSTEAELNQSLTFPSLKPAFQHSFTERPQTIHMRFPAGFQVYKCTEYPFLRNGGGVTEFWCPWQRMMLGNIEVPGFKELRMRYRNIGGSVGRPQEFARVRNAVTNEWNAMSSLTKAELRLPVWGFIGVCSNQLVSTAQEKERPSGAPPTAKVVFLGGDYQLLLPNMTAEHIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X309</accession>
    <name>E8X309_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formaldehyde dehydrogenase, glutathione-independent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1080</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1080"/>
    <dbReference type="EnsemblBacteria" id="ADW68143">
        <property type="protein sequence ID" value="ADW68143"/>
        <property type="gene ID" value="AciX9_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1080"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_0"/>
    <dbReference type="OMA" id="CETVDVS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014184">
        <property type="entry name" value="HCHO_DH_non_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02819">
        <property type="entry name" value="fdhA_non_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="3">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="2">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="44921" checksum="313CA6762C4E92CD" modified="2011-04-05" version="1">MGLGSAQADRARSRYIVGPHNALESDKDCAMAENRGVVYLGQNKVEVQSIDFPKMQNPAGKKIGHAVILKVVSTNICGSDQHMVRGRTTAPTGMVLGHEITGEVIELGSDVEYIKKGDLVTVPFNVACGRCRTCRMQETGVCLNVNPGRAGGAFGYVDMGGWVGGQAEYVMVPYADFNLIPFPDKDQAMSKIKDLTMLSDILPTGFHGAVNAGVGVGSIVYVAGAGPVGLAAAASAHVLGAAVVMIGDMNKERLAHAESMGYVPLDLTTSDNLTDLIEKAIGQREVDASIDAVGFEARAQGKDGAEAPATVLNSLMTVTRAAGSIGIPGLYVTEDPGAHDDASKTGNLKMRFGLGWAKSHRFYTGQTPVLKYNRQLMQAILYDRLPIGKIVNATVIPLSEAAKGYADFDKGAAKKFVLDPHGLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X318</accession>
    <name>E8X318_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1089</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579475.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1089"/>
    <dbReference type="EnsemblBacteria" id="ADW68152">
        <property type="protein sequence ID" value="ADW68152"/>
        <property type="gene ID" value="AciX9_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1089"/>
    <dbReference type="eggNOG" id="COG5617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033047_0_0_0"/>
    <dbReference type="OMA" id="ANPYMLF"/>
    <dbReference type="OrthoDB" id="1342047at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="600" mass="65734" checksum="509E36A21D269828" modified="2011-04-05" version="1">MPSRAHRYLIPLAAFLAILPMLIHGPSCGHDFDFHLLNWLEVNTQLHHLVWPTWAFTPAYNAGEPRFLFYPPLSWLLGAALTAILPFHYVPIAFTWLALTLSGLTLHRFASPYTTPAAATVASILYLANPYMLFTAYERTAYAELLAAAFIPLLFAAILTPRPKIVAIAIPLALLWLTNAPAAVMASYTLAVLTLIRLATPPFVEARKEARTKPRVPHPHRSLFAIRMGIARMRDPATNLHLALTVLTATTLGLALAAFYILPAALNRRYVQISMAVIPGMSPADNFLFHHTPDADHDVVLHTASLIACILIAATTAALLSTYGLRLTARRNSPTTTPTPATTRLEAHSWRLIAGRKTLPTLPLTLLAILIAALLTPISLPIWTHTPQLAFLQFPWRLLALLAPICAVAIAIALKPYPRAILCTPLLAILILPAWHTFQQSCDTPDTPESRAALYHSPLGTEPTDEYTPTEADPEALHPEDPPYWLTPQTKDQTASADTPAPTSLPPGPAPNHLTLTPTTPQTLILNRRSFPLWTVELNHHPAPILDRTDGLIALAIPAGTDTIDLIPTHPYYQPLGRIISLLAALILLCLFIRRSPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X332</accession>
    <name>E8X332_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2212</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2212"/>
    <dbReference type="EnsemblBacteria" id="ADW69256">
        <property type="protein sequence ID" value="ADW69256"/>
        <property type="gene ID" value="AciX9_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2212"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969459_0_0_0"/>
    <dbReference type="OMA" id="AVRQWTY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234127" evidence="1">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13071" checksum="AB04382BC2175933" modified="2011-04-05" version="1">MQKAIFGLLLMCGMVLSAGAQQGVDMPKHVIRVSGGVMAGRAMTKVDPVYPPEAREKKISEVVVLHAVIGADGTVKDLNAVSGPGILIASALEAVRQWTYEAYVLNGNTVAVDTTITANYSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X354</accession>
    <name>E8X354_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 29 (Alpha-L-fucosidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2236</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580594.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2236"/>
    <dbReference type="EnsemblBacteria" id="ADW69278">
        <property type="protein sequence ID" value="ADW69278"/>
        <property type="gene ID" value="AciX9_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2236"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_1_1_0"/>
    <dbReference type="OMA" id="LPEHKWE"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230191" evidence="6">
        <location>
            <begin position="28"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosidase_C" evidence="7">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="474" mass="52926" checksum="1C15A2FA1EC25DB7" modified="2011-04-05" version="1">MESSSRHKTFCRAALSAVLSLSFIATAQAPRHYQPTIESLDQHPLPQWFDDAKLGIFIHWGLYSVPGWAPLEQVNFSKPDFLKNNPYAEWYYNTVRIPGSPTQAYDRQHFGANHNYYDFAETFNAESKKWNPDVWAKTFKDAGAKYVVLTTKHHEGFTLWPSAIPNPTLPAARQHATRDLVGDLTTSVRNAGMKMGLYYSGGFDWTFVPGPIATHADFDPAKPQTEAYGKYVDAQYRELIQRYHPSVLWNDIDYPKSGHPLELEAEYYNAIPDGVVDNRFGIKHTDYDTPEYSTLKDINPKKWEECRGLGQSFGYNRAEGEAETIAADKLIYLLVDIVSKNGNLLLDVGPEADGTIPAVQLSRLKALGTWLNQNGEAIYGTHPWTHAEGKTADGIDIRFTQKNQTLYATLMGNLKGSSVTITALKLKPGTKVQLLGTKQPVTWSQEGADVKLNLPSTLPGKYAYVLGIGKSGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D0</accession>
    <name>E8X3D0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3425"/>
    <dbReference type="EnsemblBacteria" id="ADW70431">
        <property type="protein sequence ID" value="ADW70431"/>
        <property type="gene ID" value="AciX9_3425"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3425"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026775_0_0_0"/>
    <dbReference type="OMA" id="TQVAQHI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="166"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="293" mass="31953" checksum="E7AD5962720CB75B" modified="2011-04-05" version="1">MAKSSLAAILRTHEAALLNAWLAEPSQTANIRNRISEAELRSQSREFLELFQQAVTEAGEHTSLNTGFSDLSSPAFKPLRRFLETVSASRTQLGFSPSETAMFVFSFKPALFAHIRTTDLDPISQVEELTLASSLLDGLGLLTTEAHQKVRESVILRQQQEMMELSTPVVKLWDGVLALPIIGTLDSSRAQTIMESLLERIVATGSEIAIIDITGVPTVDTLTAQHLLKTVTAARLMGAECIISGIRPQIAQTIVHLGVELGDVITKASLADAFKIALQRTNYTIVKRTTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F0</accession>
    <name>E8X3F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3446"/>
    <dbReference type="EnsemblBacteria" id="ADW70451">
        <property type="protein sequence ID" value="ADW70451"/>
        <property type="gene ID" value="AciX9_3446"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3446"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019327_1_1_0"/>
    <dbReference type="OMA" id="IDHEFIH"/>
    <dbReference type="OrthoDB" id="453021at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="548" mass="57690" checksum="F4C738C82D9D2259" modified="2011-04-05" version="1">MVDARFHQAQTADGERADGQRTDSRGTDGQSTGGEGTESKAGFAGEQTHAHEMRLTAPAPLRSTTTLNLLQSLQPSMPTASIIGSGPNGLSAAITLAQAGLETTVYERNAQAGGGCSTGEITLPGFRHDLGSSAYPLGIASPFFNSLPFEVPIPWVQPPAACAHPLDDGTAVLLERSLADTIENLDAADARKYRSLIEPIADAFPRLIVDLLGPIQHIPKHPLLLARFGLSAPLPAASLARSRFKGPRARALFAGMAAHSVQPLEMPGTAAVALVLMAAGHAVGWPILAGGAQTLTDALIAHLQSLSGRVELNHEINTLTQLPDTLTLADITPRQLLQIAGPTLPHAYRTQLESFRYGAGAFKVDYALSAPIPWTAKECLRSATVHLGGTLEEIAASERGFNADKPFVLLVQPSLFDPTRAPEGKHTAWAYCHVPNGSTADHLAALEAQITRFAPEFQDVVLARTVSPPAALERWNPNLIGGDLSGGAMTPSQLLFRPTPSLYGTPLPNLFLCGASTPPGGGVHGMAGFHAARAALRSQTANHPRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G3</accession>
    <name>E8X3G3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3459</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581775.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3459"/>
    <dbReference type="EnsemblBacteria" id="ADW70464">
        <property type="protein sequence ID" value="ADW70464"/>
        <property type="gene ID" value="AciX9_3459"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3459"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_0"/>
    <dbReference type="OMA" id="RHTGMHQ"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="34679" checksum="F5766757BD95F457" modified="2011-04-05" version="1">MTTRWKLSDMPTQAGKRFFITGANSGIGYYAALELAKRGGIVVMACRDQARGQAALERLKREATGPESAASEAELVVLDLASLASVRAAATAECTRNLPLHCLINNAGVMAPKQRLETRDGYELQFGTNVLGHFALTCLLMPLLERGRASRPEDASRVVTLASIAHKSGKINFDDLESERSYSPMGAYQQSKLADLMFSFELERCLREKNLGVVSLAAHPGVANTNLFHAGEVSAAEKLGRKFMGTLFDLFLNSEQGGALPTLYAATADSAEPGAYYGPQGFMEMRGGDVGPAKIAPQALDQKAQKRLWEICVEETDTKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J2</accession>
    <name>E8X3J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579506.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1120"/>
    <dbReference type="EnsemblBacteria" id="ADW68183">
        <property type="protein sequence ID" value="ADW68183"/>
        <property type="gene ID" value="AciX9_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1120"/>
    <dbReference type="eggNOG" id="ENOG502ZBW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093484_0_0_0"/>
    <dbReference type="OMA" id="GGQWAMI"/>
    <dbReference type="OrthoDB" id="1918376at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="20630" checksum="9B7C7B725323DD58" modified="2011-04-05" version="1">MTTNQATFNPSTANHFLRNLYLSRTVVQIVWAATVLATASTSPNLAVALVVLYPLWDVVCTIRDIRSNPQPESRSLLLTNAILGTATAIAVGILGSVQVRYAVALFGLWALLAGLLQLGVGIARRRSAKGQWAMILSGAQSTLAGTAFLIRGLQEKIHVKDLGGYAIFGAVYFLIAALLLSRKGSTPDTALHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S4</accession>
    <name>E8X3S4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea carboxylase-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580668.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2315"/>
    <dbReference type="EnsemblBacteria" id="ADW69352">
        <property type="protein sequence ID" value="ADW69352"/>
        <property type="gene ID" value="AciX9_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2315"/>
    <dbReference type="eggNOG" id="COG3665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079904_0_1_0"/>
    <dbReference type="OMA" id="HNINFFM"/>
    <dbReference type="OrthoDB" id="969451at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017791">
        <property type="entry name" value="Urea_carboxylase-assoc_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03424">
        <property type="entry name" value="urea_degr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24477" checksum="51044895ABE156D0" modified="2011-04-05" version="1">MSDTIIQESPRLTDACFLDEIIRAGDSFVHEIKQGQFVRIVDLEGNQAVDTLFYNAHNYADRYSAQDTIRAQANIYLTTGTRLISTQRNTLLTIVADTCGRHDTLGGACSTESNMVRYDIEKRSMHACRQSFLKGALTWSASTGRDLDKRDLTANINFFMNVPVTPAGKLTFEDGVSDAGKYVELRADMDVLIVISNCPQLNNPCNAYNPTPARVLIWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S8</accession>
    <name>E8X3S8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2319</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580672.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2319"/>
    <dbReference type="EnsemblBacteria" id="ADW69356">
        <property type="protein sequence ID" value="ADW69356"/>
        <property type="gene ID" value="AciX9_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2319"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_0"/>
    <dbReference type="OMA" id="GVGYMIM"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="97"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="32454" checksum="5EB955103D0DBE2C" modified="2011-04-05" version="1">MSSFAPFDIQARPNRLVAQALSFVFFLVCLGLYVHTSKVRHADNPEDRIVPNAQQLRAGIHASVLEPAEEDDYIAPDGASKWERFHHSMIWKDTLSSGRRFGIALLLLVPAVLLALHIGLFPYFNSGGMRFLLFFDKIVALSLLPILFIVFGIDEWSKIALIVIGVAPTMMLDVIQMVRTVPQEQVVKSFTLGANDFDVAYRVIFRQILPQIINSLRLNLKPIMLFLFAGEMIAASDGLAYRIAIMRRHMGMDVILPYVLWVALLLFCVDLSLRIVNRRMHPWFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V8</accession>
    <name>E8X3V8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2349</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2349"/>
    <dbReference type="EnsemblBacteria" id="ADW69386">
        <property type="protein sequence ID" value="ADW69386"/>
        <property type="gene ID" value="AciX9_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2349"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_0"/>
    <dbReference type="OMA" id="PYKEEHL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14274" checksum="F3107AE7353CAAD2" modified="2011-04-05" version="1">MRVLIVDDSAVMRKVVERALRQSGLPITAVLQANDGQQALDLLREPTQEPLDLILTDINMPGLGGLDFLEQRNQQSLAPGTPVVMITTEGSEALVHRAIAAGAKGYICKPFTAEQIRARVCPLLPTCTTPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W5</accession>
    <name>E8X3W5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="8" type="ordered locus">AciX9_3468</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581784.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3468"/>
    <dbReference type="EnsemblBacteria" id="ADW70473">
        <property type="protein sequence ID" value="ADW70473"/>
        <property type="gene ID" value="AciX9_3468"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3468"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_3_4_0"/>
    <dbReference type="OMA" id="WCVQIGA"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPBB_1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="7">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27485" checksum="9C053C0C4AE3FBA7" modified="2011-04-05" version="1">MMGRSSGRVVQGVLGVGILLLSGCHHAKTTYDTSSAPPPPPLPSRSEAVPHRTAPQPGSAAPIVRKPPAGEPDDLSGPPISTEVGLASWYGPPYHNRQAADGSIFDQNAMTAAHRTLPMGSTVRVTNLDTGESVVVKITDRGPFVPNRILDLSLAAAKATGLYQKGVAKVKVEVYAHNTADPGGRWCVQIGAFLTADDAIQLKNDLLQRYKTAKVIEFQGPTGYWVRINPAQADKLTASNILESIHIPDANPYLVRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z7</accession>
    <name>E8X3Z7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3500</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581816.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3500"/>
    <dbReference type="EnsemblBacteria" id="ADW70505">
        <property type="protein sequence ID" value="ADW70505"/>
        <property type="gene ID" value="AciX9_3500"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3500"/>
    <dbReference type="HOGENOM" id="CLU_2493546_0_0_0"/>
    <dbReference type="OrthoDB" id="2230891at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9709" checksum="B61F40DA45026C8A" modified="2011-04-05" version="1">MPVLFSRMREFENQRVHMVFDDDHEVVATLLSATEDIEGSHHLIYDKVEWANDPREFATAKDSSVYAEGESLVSIEAAEAVESTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X412</accession>
    <name>E8X412_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_3515</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3515"/>
    <dbReference type="EnsemblBacteria" id="ADW70520">
        <property type="protein sequence ID" value="ADW70520"/>
        <property type="gene ID" value="AciX9_3515"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3515"/>
    <dbReference type="eggNOG" id="COG3548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243867_0_0_0"/>
    <dbReference type="OMA" id="IRASWIV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="23939" checksum="C8B87F6CC8F1F696" modified="2011-04-05" version="1">MPKEQPSPGRLEAFSDGVIAVIITIMVLDFKVPHDPGPAAFARAILPTLAVYFLSFTFTGIYWVNHHHLVHRIRHVNAPMLYGNLFFLFCLSLLPFATSYALEKHFDSFSVAVYAGALLLSGIGFIALSLAIGRHLHRTGGVEDPTDAAIQQAERSKAFLSLAMYALAMPSPTGTPSSPRLRSPSSPSSGSSPASSSRQPTKTARPTAPSDRYGILSSRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X465</accession>
    <name>E8X465_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0034"/>
    <dbReference type="EnsemblBacteria" id="ADW67125">
        <property type="protein sequence ID" value="ADW67125"/>
        <property type="gene ID" value="AciX9_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0034"/>
    <dbReference type="eggNOG" id="COG3918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125942_0_0_0"/>
    <dbReference type="OMA" id="CWFAYLH"/>
    <dbReference type="OrthoDB" id="1952216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="16817" checksum="7CD5EBD5F65B1C46" modified="2011-04-05" version="1">MLAWMIAIPALGFMTGLRSMMPMAVLCWFAYLHHMPIHHSWAFWVASPISVGVFSVLAVGELIGDKLPMTPARTAIGPLVARICFGGLVGTIAAMSLRGAPVEGLLLGVLGALAGSFLGYHIRIWLTKDFGWPDLIVALAEDIIAIVVSVYAMGIVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E4</accession>
    <name>E8X4E4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1208</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579594.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1208"/>
    <dbReference type="EnsemblBacteria" id="ADW68271">
        <property type="protein sequence ID" value="ADW68271"/>
        <property type="gene ID" value="AciX9_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1208"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_4_0"/>
    <dbReference type="OMA" id="VFQIHKY"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234158" evidence="4">
        <location>
            <begin position="27"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="477" mass="53062" checksum="B6C3751364695D3F" modified="2011-04-05" version="1">MPSSTQLSRRGFLVSALAAGSAYALGADKPSGRRPNIVFILADDMGYGDPAVYGQTKIRTPNIDRMAAGGMRFTQGYAGAPVCAPSRCTLMTGMHGGHARVRDNFALAAGHVGHKKKEEIRRASLTTEDRTVADYLRGAGYRTGLMGKWHLDGYDPDAVPTKHGFEEFKGWLTQIDETQGYWPEKRMHGETLIDIPENAGGKQGRYDTTMITEDSVDYIERHKADPFFLYVAYDSPHSPYTAPDFGPYKDHPTWADDEKTYAAMIWYMDLGIGKILDTLKRLKLDEDTVVFFASDNGPRSEPTVQQTRVIDFFDSNGNLTGYKRDMYEGGIRDPLIARWPGHIPAGAVNQMSAYFPDFLPTALDLAGAPVEKGDGISLRPYLMNPKLTGEERFLYWEFYEPVFRQAARLGRWKAVRLKRGGKLELYDLSVDAWESKDVAVDHPEIVAKMEAGMAREHRASAEYPDPGKGAVAAPNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K0</accession>
    <name>E8X4K0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase (SpoU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2373</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2373"/>
    <dbReference type="EnsemblBacteria" id="ADW69410">
        <property type="protein sequence ID" value="ADW69410"/>
        <property type="gene ID" value="AciX9_2373"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2373"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_0_0"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="27469" checksum="A7112E1C86ADF7CD" modified="2011-04-05" version="1">MSFSGQVVTSRTNPRLKQLRAAFQGQARLSSGLIAVEGEHMVEEALKSGQALKTVFLSERMELPAYVPASVEVVSVASDVFASIAETRTPQGIAALLVPPAHSVEKMLEGPGEALILIAVGLQDPGNLGTLIRSAEAFGATGVLTTPGTVSPWNQKAMRASAGSVFRLPVAVATPDAMETLEQQGIKLLAAMKDDAVAIGEADLTVGSAILIGNEGAGLNEDWLRLADQRVTIPCPGWVESLNAAVAGSILLYEASRQRGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L1</accession>
    <name>E8X4L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2384</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580737.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2384"/>
    <dbReference type="EnsemblBacteria" id="ADW69421">
        <property type="protein sequence ID" value="ADW69421"/>
        <property type="gene ID" value="AciX9_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2384"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_0"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="273" mass="30515" checksum="144BD37D68C4D456" modified="2011-04-05" version="1">MSEETTKVTPAEMESLREAIAIMARLRGPGGCPWDREQTFESIKRHTLEETYEVFDAIDRKAWPELKDELGDLLLQVLFYAQMASEAGYFNIQDVAANLSAKLIRRHPHIFGDASAETADDVNRNWEAVKRQEKAERGDAPAGLLADVPRHVPAMLEATKLGAKAAKVGFDWADEGGLFTKLEEELEELRLEVRPGEAGSERAFDELGDLLFTAMHLARKLKLDPEFALRGANAKFRRRFNAMEAAAGGTETLQKASEEELDAMWRLAKQQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M4</accession>
    <name>E8X4M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prepilin peptidase</fullName>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2397</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580750.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2397"/>
    <dbReference type="EnsemblBacteria" id="ADW69434">
        <property type="protein sequence ID" value="ADW69434"/>
        <property type="gene ID" value="AciX9_2397"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2397"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_0_1_0"/>
    <dbReference type="OMA" id="VFWLFKL"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="9">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="8">
        <location>
            <begin position="127"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="34349" checksum="FDE7F1C00CB0EECA" modified="2011-04-05" version="1">MLSPVFFEAAGLLLGLLFGSFLNVCISRLPQHQSVVTPRSKCPGCEHPIRWFDNIPLLSWVLLRGRCRDCKERISWRYPAVELATGLWFARAGAQIRELHYVSAFGLGPLSGSQLLEGYVQILAIAVLGFLLIGLIVMDWQTQRLPDAFTLGGIFAGLFLVCTQAIFLGPTEAQINLTSHHLRMSSPGSFVGRGNVFLTGPEHLIFGRLLAVAGIAAILLTIRALYKAVRHRDGLGLGDVKMLAMVAAFLGFWPTILTLFLGTFLASAYAIPLVLRRRANALTKLPFGSFLGIAGLLAALFAEPILNWYAGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S6</accession>
    <name>E8X4S6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3561</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70565">
        <property type="protein sequence ID" value="ADW70565"/>
        <property type="gene ID" value="AciX9_3561"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3561"/>
    <dbReference type="HOGENOM" id="CLU_1508571_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="18605" checksum="64E5D31F7DE8BCF9" modified="2011-04-05" version="1">MFRDLFYLLVGFLGFFCLAALGWEVGGGDLEAVEEEAGAAVVELVGGDAAQDLADGELDGGSVFGEWQIEGGVAVLVCVTGCQVGAWDGFAGGVVVVAEVLVAEGWTAAAASVGVDVAALVACGCFDCLSLCGHGWGSPPPVKVCKVFRRLMLWVDFFLSTVVHCQLWRRGFSSSYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X554</accession>
    <name>E8X554_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ordered locus">AciX9_1256</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579641.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1256"/>
    <dbReference type="EnsemblBacteria" id="ADW68318">
        <property type="protein sequence ID" value="ADW68318"/>
        <property type="gene ID" value="AciX9_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1256"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_2_3_0"/>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="15410" checksum="50CBA9FA102C1BEE" modified="2011-04-05" version="1">MLKGFRDFILRGNVVDLAVAVIIGAAFGAITASFTADIITPLISAIAGTPDFSSLVIHMPVLHAVTPPSPLPANYIPPGELHVGKLLNAVINFLIVAGVLYFLVVMPIGKLLARLNPPAAVTTKPCPQCLSDVPLAATRCKFCTQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B8</accession>
    <name>E8X5B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix Fis-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2429</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580781.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2429"/>
    <dbReference type="EnsemblBacteria" id="ADW69465">
        <property type="protein sequence ID" value="ADW69465"/>
        <property type="gene ID" value="AciX9_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2429"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184588_0_0_0"/>
    <dbReference type="OMA" id="LGMHRNT"/>
    <dbReference type="OrthoDB" id="1933378at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_8" evidence="2">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="11008" checksum="5E12889CBE018B78" modified="2011-04-05" version="1">MKRELDALITQMHSAGVSYTEAVRQFKRRYLLEVLAQHKGNQCKAAEELGMHRNTLSRTLAELDMDTAQIRSGMRRPPMSERPRTLPSVANLTKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E9</accession>
    <name>E8X5E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2462</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580812.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2462"/>
    <dbReference type="EnsemblBacteria" id="ADW69496">
        <property type="protein sequence ID" value="ADW69496"/>
        <property type="gene ID" value="AciX9_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2462"/>
    <dbReference type="eggNOG" id="ENOG502Z7JZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_2_0_0"/>
    <dbReference type="OMA" id="ECEGWER"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="19286" checksum="9A3F50F80C11DA1C" modified="2011-04-05" version="1">MAQFVVNNRKDPYKNFKFRILWDGRYVAGISKVTMLKRTTEVVKHREGGDPSTSRKSPGRSEFDAVTLDRGVTHDEAFEAWASKVWKFKGGLGSEVSLADFRKDITIEMYNEAGQKVIAYQVYRCWVSEFQALPDLDANANAVAIQHLKLENEGWERDTSVKEPKEPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I4</accession>
    <name>E8X5I4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteophosphoglycan 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581922.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3608"/>
    <dbReference type="EnsemblBacteria" id="ADW70611">
        <property type="protein sequence ID" value="ADW70611"/>
        <property type="gene ID" value="AciX9_3608"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3608"/>
    <dbReference type="HOGENOM" id="CLU_1813067_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="13922" checksum="4834FEDAAA9A3FC3" modified="2011-04-05" version="1">MSLTTIPVASVADYNSSSAGVATVPAPDADSTSTPIVSAGSTAPPNPLAKDLSALLTDLASGNIQKSSEDLLKLKQDLKAQQSLQGPTASASQAPGTGSLEKVVSSISSALNSGSTEDALAGLSSYLVQSGQSSGTAVKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N2</accession>
    <name>E8X5N2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3656"/>
    <dbReference type="EnsemblBacteria" id="ADW70659">
        <property type="protein sequence ID" value="ADW70659"/>
        <property type="gene ID" value="AciX9_3656"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3656"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="DSIYATW"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234418" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1152" mass="123681" checksum="A739344478AC7A29" modified="2011-04-05" version="1">MKLSPALRRATMLGIFAASLTAAHAADVNARIKGTVTDPAGAVIPNVKVIAINQATGVKFTTTSQANGDYLFPQLPIGTYTISASATGFKGFAAKGIVLNIDQEYVEPVKLDLGSASETISVQADAVQVNTTDMQLNNIVNADQFVELPLIGRAFTNLEQILPGVQASNDRFGSFSVNGSQTQQSSYLINGADSNDIALNTIGIQPNLDALAQFNLVTGPLNAEYDRNSGAVVSTVIKQGTNQFHGDAFDFYRDTFLNTKNYFQTKASKYHQNIYGGTLGGPIIKDKLFAFFAFQGQKAVTPQTGGNVTVLSPANLTGDFSADLNPTSANAFQANPVPGTLKAATGCTLPGETWTQCFPTGKIPTTAFNPVSLNLIKAFLPAANTGTNGFQFNPVTTQTQRQYIGRMDFNPTAANQFYFVAIQQHFPSSDVLPFTGGTVPGFGDQNTSEIYQYSAGFIRQLSSSSVNNLEIHYTRFNFGSVSPQNVVQPSTLGFSITPQNAAAASVPFIGVTGFFNLGFSTNGPQPRKDQNYQADDNFSKVVGHHNLKFGYDGRRYNVSNPFFSNNNGAFSFNSATNIFTTGDASLDFLLGNPSTYAQGSGAQINAYAFLNYMYAQDTWKATNSLTISYGIGYQIDTPLHNTQYNNEGVTCFIPGQQSKVFTTAPIGLNYPSDPGCNNASGATTRYTNFGPRFGFAYAPDFGFLSGGSAKKLSVRGGFGVYYNRSEEETSLNNLGDAPYGLNSSGAADYGATNPTFANPYQDLDTGTVYKNKFPATFATAGQTPDFSPFEPLSLSQYSPNFRSPYSENFQLTVERELPSQTIARLSYVGTLGRHNQFSVEGNPVTAAGHAACLASAACITNRNIQSYVYPTHTQFGVANASTGFNNFTSIGTVTTEGASSYHALQASVEKGLTHGLLVQASYTYSHSLDNGSSYEGTGYGGTNRGYNQYQPSLNYGDSNFDARHRFVFSPLYRVPFKSGGNAFSLRNLAASGWEVSGVSTFATGFPFDISYGGGTSRSLWCSASFSYYACPDVPNQIAPLVRANDRTRSATTGYTTWFSPASFAAEPIGAFGNVHRNPYHGPGLLNTNIIVAKNISVSSDSTRYFQLRLESDNVFNHTQFSNPDGNIGDSTFGQITSAAAGRQTQLAGKFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R4</accession>
    <name>E8X5R4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virulence protein SciE type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4002</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572710.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70798">
        <property type="protein sequence ID" value="ADW70798"/>
        <property type="gene ID" value="AciX9_4002"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4002"/>
    <dbReference type="HOGENOM" id="CLU_087908_1_0_0"/>
    <dbReference type="OMA" id="GRYYWIP"/>
    <dbReference type="OrthoDB" id="977924at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009211">
        <property type="entry name" value="TagJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07024">
        <property type="entry name" value="ImpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="27344" checksum="5A314C9322A43129" modified="2011-04-05" version="1">MTALDLYKKGELQEAIKVLGDEVRSNPLDTKRRTFLFELLCFAGNYDRAEKQLDFLAGDGGKTAAGALMYRSALHAERTRQDLFAKKAYPELNASVEPLTGMWNGQAFSDLRDADPRIGANLEVFIAGSYTWIPMKYMEQIEIEKPESLRDLIWARARIETSKAFRLQDLGEVLIPVLSPFSYQQADDAVKLGRMTVWESADGEAEVPFGQRMMLIDGEEVPLLELNSIDWERIAEEVADASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X5</accession>
    <name>E8X5X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4076</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70859">
        <property type="protein sequence ID" value="ADW70859"/>
        <property type="gene ID" value="AciX9_4076"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4076"/>
    <dbReference type="HOGENOM" id="CLU_361219_0_0_0"/>
    <dbReference type="OMA" id="CERTNSQ"/>
    <dbReference type="OrthoDB" id="334975at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="835" mass="92205" checksum="3EC1925CBDEB2B80" modified="2011-04-05" version="1">MVVFDMLLLKRKILRRQGGKHGLIPRANVCLVFIHDPIDSLSPLMLLEMQPKIRFEGYLIDRPAWRLQWQDETIVLNRRTFDLLLFLIDHRDRVVPKDELLQSLWRDQFVEESNLTQHVFLLRKALSRHASGQKIVETVPGRGYRFTAPIEVEPQAVEETATSSQIFLHASASVTEITIEEEEIEADSTSLAALPTVRKDGRTRWALGSLLIVVGIAIAGWFGWQHWLDRTGGAPVDVVIAPSAGSTGDAVLDSALVDALRMDLSQSPFVSPVAPARVRATLTEMKQDPDAAMTTAVAAEVCERTNSQAVLHGNVARFGQHFLLTEEATSCVNGSMLAEAKQEVATAEGLPHGIDKLAEKIRRDLGESRRSIARFDIPLFPGRTASLEALKEFTQAQVQSNQGKYVDAIELMKKAVAADPGFAEAYYDLAAYYGSVLALTAERDALLKAYSLRDTASEPVRLGIVALYHSAITQDLYEAERNYRNWIELYPRSAQAWNGLSNVERELGHHQDALTAAEHTLELRPTVAGLYANLAFEQMKTDNPKGALATCKRALARGMDIDNIREHCFQAAYALHDDAEVQQQREWAAAHPDAVYIRFDEVIIAIAEGRFSDVQRLAPPLNAIMRQRGLAEPADGFLRDTGTNLIESGDVAEGIRILRSAPVDLKDETSVLGLARAGDIAAAENAVRAMQAEFPQGTLWNDYRGPEIQAIIALATHKPKDAIIALERVRPLEGRDPVISMMRGDAYLAAGEPAQAEAAYRKVIEGPDQEPEAEEVPLSWLGLGRALAAQGRRPAALEAYQHFLTLWAHADSNAMHLVEAKKELGSLQNFGHLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X607</accession>
    <name>E8X607_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4111</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70891">
        <property type="protein sequence ID" value="ADW70891"/>
        <property type="gene ID" value="AciX9_4111"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4111"/>
    <dbReference type="HOGENOM" id="CLU_425603_0_0_0"/>
    <dbReference type="OMA" id="YGMAPDW"/>
    <dbReference type="OrthoDB" id="764475at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="630" mass="68980" checksum="620831BD9C15F890" modified="2011-04-05" version="1">MTKTALADWLLSDIRLPKGVQGHPEPEHPWWRVMCLTGVDYFSTLGYQPGIAFLAAGFLSPIATFVLVLVTLFAALPLYSRVAEVSPNGQGSIAMLERLFPQWGGKVFVLVLLGFASTDFIITMTLSAADAAAHFIHNPFAPHWLTSQMLVTLLLLAGLSAIFLKGFKEAIGIAVVLVGAYLFLNAIVTVVAFNVLFHHPEAFPRWKSAVHEHHPNILGMIGLSLLLFPKLALGLSGFETGVAVMPLIAGKDLQDRIHNTRKLLATAAIIMSVFLMATSIVTTMLIPRAAFAEGGEASGRAMAYLAHQYLGNGFGTVYDISTILILAFAGASAMAGLLNLIPRYLPRFGMAPEWALASRPLVLVFMTTAVFVTIAFHADVNAQGGAYATGVLVLITSAAVAVTIHVWKKPLLRFAFAAITVIFIYTTALNIYERPEGLKISSFFILAIITTSVVSRAMRSTELRISEVELLPEAVSMLAEDEDQVIRLIARSPKEEEDKHCADELDALDAFVRTRYGMTPTECLYFLEIERIDASEFEHCLCIEARRVGRHRILCANSPVVANSIAALLMHLEETTGKLPHAYFKWKEGNPVVNIIRFIFLGEGDTAPLTHEVLRRAVPNPDRRPIIHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X616</accession>
    <name>E8X616_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4120</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572812.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70900">
        <property type="protein sequence ID" value="ADW70900"/>
        <property type="gene ID" value="AciX9_4120"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4120"/>
    <dbReference type="HOGENOM" id="CLU_1793775_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="15746" checksum="F71FA15EF13AFC64" modified="2011-04-05" version="1">MQTALTQSQIQSVVTTLSPLEAQEYLESIQALTHELDRAMEAIVSRELPAFEQSVSRQMSACVKLAELPKRSARRVRDVSSEAAPDAELTGRIAAASVALVALNKRYSALLKHSGDTLRMFAGLFRSYTGTTQPGMLSTWSCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X629</accession>
    <name>E8X629_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III secretion exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4133</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="N06.A01"/>
    <dbReference type="EnsemblBacteria" id="ADW70913">
        <property type="protein sequence ID" value="ADW70913"/>
        <property type="gene ID" value="AciX9_4133"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4133"/>
    <dbReference type="HOGENOM" id="CLU_041013_1_0_0"/>
    <dbReference type="OMA" id="DEYKQQE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="367" mass="40344" checksum="A9F932CED409EAD7" modified="2011-04-05" version="1">MADSNKTEEATPKRRQKAREQGQVARSKELPSVLAIAGAIGALCMMSQSAVTHWTTFYRSMLDTASTSDLESNGPILFWGSVEVFRWIIPVLMSATVLSVAAGLAQGGLSIAPEAMQLKFERFNPASKVGQIFSLAGVSNMLKSLLPFGAIAWIGEACIRSNWGMLIRASSFGLRQLVTTLGGMIFEVAWKSALVLVAWAGVDYLLTWKKMEGDLKMSKEEIKEEYKQNDGNPLIKSRIRRLQRRMRKKQALAAAATATVIVTNPTHYAVALRYTPEMAAPEVVSKGMNLLAQQIKALGAENGIMILENKPLAQALYKTVEVGEVIPSTLYQAVADILVIVFRAQAEVRQQEAMRRNRNASGELVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X644</accession>
    <name>E8X644_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliE</name>
        <name evidence="5" type="ordered locus">AciX9_4148</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70928">
        <property type="protein sequence ID" value="ADW70928"/>
        <property type="gene ID" value="AciX9_4148"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4148"/>
    <dbReference type="HOGENOM" id="CLU_147249_3_2_0"/>
    <dbReference type="OMA" id="LHDVMIT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="10871" checksum="95F8722AFA8E8B4A" modified="2011-04-05" version="1">MNIPIGGMSIPIPTGMTTPSFGGMTDPSQSGGFSDVLKGAISQVSNLEGSANQQVNRLIQGGNADMSKVMISVEKADVAFQLMMQVRNKIVSAYQDIEKMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X646</accession>
    <name>E8X646_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4150</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70930">
        <property type="protein sequence ID" value="ADW70930"/>
        <property type="gene ID" value="AciX9_4150"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4150"/>
    <dbReference type="HOGENOM" id="CLU_125463_3_2_0"/>
    <dbReference type="OMA" id="RARKVKF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="12673" checksum="B937ECE5FD243D91" modified="2011-04-05" version="1">MATTSLLPPSLERFLELTTDREQTIASNMANVDTPGYRTKDVNFKQAMMTASSGADGSEFTPVVNKVNGLLERPDGNNVNLDRESLLLAQSQLQYSLGTQLVKGQFHQLLSAINGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X647</accession>
    <name>E8X647_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4151</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572843.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70931">
        <property type="protein sequence ID" value="ADW70931"/>
        <property type="gene ID" value="AciX9_4151"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4151"/>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="PTNSRVM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="139"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="454" mass="49642" checksum="0090B8DCFD248795" modified="2011-04-05" version="1">MNFAQPSSVLIVDDEAGIRTALRVNFARNGWTVETASGVTEAARLLESKEFHLVVSDMRMPDGNGLEVMRSARKVSPSTAVILLTAFGSVPDAVQAMRGGAFDYLTKPVSFEQLEEAAARVMQPVKDAIRPDTSDTGSIVGRAPQLLRAISRARAASSTDADVLVEAESGTGKELLARFIHEASNRARKPFIAVNCAAVPEHLLESELFGHARGAFTGATTAKPGKFELANGGTLLLDEIGEMPLNLQPKLLRALQEREFERLGETRSIKVDIRVIATTNVNLASMVDEGKFRSDLYYRLNVIPLSIPALKDRAGDIELLANYFVEKFAAKLGGPAPRLSAEFVDRLNAHNWPGNVRELGNFMRRVCSLHPSVLLDADCFDQEFQTRTKAIPAAASAPLVIAGAPIRQLERVHLENTLAMTQGNRTQAAEMLGISIRTMRNRIREYGLPPRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X668</accession>
    <name>E8X668_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4172</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572864.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70952">
        <property type="protein sequence ID" value="ADW70952"/>
        <property type="gene ID" value="AciX9_4172"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4172"/>
    <dbReference type="HOGENOM" id="CLU_709329_0_0_0"/>
    <dbReference type="OMA" id="HLGECAR"/>
    <dbReference type="OrthoDB" id="2209685at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="36060" checksum="9452FE4351487410" modified="2011-04-05" version="1">MSELIQAGQHLDADTLNAFVEQELPEHERIACLAHLGECARCREIVFVAGGADEVEVVTVVAPERAWWQWGSVAWSGAAAGIAGVLVAVTMLHGRHAGVDRVAQVEAPVAEALGLKARAAAPPAASDAKAKAAAPNLAKALRYAKPTPPKAVFEEPEEAVANGALQAPLLGRDKVVTMHGSATAGGVLAGSAVADVAMQAQVSRLATAPAPVATTAAPKALPMYSRVVGKASAMPQTVTVEANSMAQIVVTQPAPVAGGLAMRAMKTAAAPIVLPNRLAVAGSAEWGGRVVAVDTAGGVFLRVDGNAGWTSVRPVWTGKAVGVDAGGTAFRLRVVDGSVWVSGDGVEWKPAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F4</accession>
    <name>E8X6F4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4264</name>
        <name evidence="3" type="ordered locus">AciX9_4281</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572950.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71038">
        <property type="protein sequence ID" value="ADW71038"/>
        <property type="gene ID" value="AciX9_4264"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71052">
        <property type="protein sequence ID" value="ADW71052"/>
        <property type="gene ID" value="AciX9_4281"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4264"/>
    <dbReference type="KEGG" id="acm:AciX9_4281"/>
    <dbReference type="HOGENOM" id="CLU_2569061_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="8435" checksum="29A97A24C604822F" modified="2011-04-05" version="1">MSKAPAAITSPKIKKLAAKALKSPSMLTNVETRELGASVMAFISLPKDIVSAPTKKSAAKKVTAKKAPTKKTVKKTTAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F5</accession>
    <name>E8X6F5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4265</name>
        <name evidence="4" type="ordered locus">AciX9_4280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71039">
        <property type="protein sequence ID" value="ADW71039"/>
        <property type="gene ID" value="AciX9_4265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71051">
        <property type="protein sequence ID" value="ADW71051"/>
        <property type="gene ID" value="AciX9_4280"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4265"/>
    <dbReference type="KEGG" id="acm:AciX9_4280"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_0_0"/>
    <dbReference type="OMA" id="GGRAYEI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="13276" checksum="BB53C72AF8637727" modified="2011-04-05" version="1">MATKKTAAKTTAIPAAKKTSTSAAKKTSTSKTMTKAALVLLVSEKMELSKKQTAEFFDLLAATAIQETKKNGEFTIPGLGKLVKAQRAARLGRNPQTGETIKIKAKTAVKFRVAKAAKDLIAPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q8</accession>
    <name>E8X6Q8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582226.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71208">
        <property type="protein sequence ID" value="ADW71208"/>
        <property type="gene ID" value="AciX9_3932"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3932"/>
    <dbReference type="HOGENOM" id="CLU_140339_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="13838" checksum="DA7A70B48D6A5757" modified="2011-04-05" version="1">MKRHDEALSSAIAITLRTGILLAVSFGVLGYLFYLPATGMTHPSFHRFEGSQIPYSSLRCIARMMMHPGGGGVERGQGIAEIGVLVLMATPILRVVLSLISFLRDRDILFAAITAVVLGALGFSVFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X748</accession>
    <name>E8X748_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4329</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573001.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71282">
        <property type="protein sequence ID" value="ADW71282"/>
        <property type="gene ID" value="AciX9_4329"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4329"/>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_0"/>
    <dbReference type="OMA" id="MGKAVCF"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="27376" checksum="A929C2849C77F9B8" modified="2011-04-05" version="1">MIYDLAQPLYNNGPQFPDQPPNSIRYYQRAVVKGATVERLEIMTHSGSHVDAPFHYKPQLPTISELPLSHFYGPCVGLDLRPVEACHAIDADDLQKHETLITEGVFLLLKTGWGDRRANTKEFLTDWPYMSGDGARYLVERGIKGLGIDVLSTGGYPDEHAEADAHLELLGAQKLLLEDIHIPDELLDGRHRHFAAFPILIANAGGSWVRPVVWDTGDLDGAQPATELRTELPPSVAGLIALERDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A9</accession>
    <name>E8X7A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4392</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573062.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71343">
        <property type="protein sequence ID" value="ADW71343"/>
        <property type="gene ID" value="AciX9_4392"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4392"/>
    <dbReference type="HOGENOM" id="CLU_2752164_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="8300" checksum="8D647BE3BF19AD45" modified="2011-04-05" version="1">MSEHMTSPPEREPPKDWWLENACRIAAHRLRNSPYLSANTIPIREQLKDSVEFVRLVWEAIEQSLREEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D1</accession>
    <name>E8X7D1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4415</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573084.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71365">
        <property type="protein sequence ID" value="ADW71365"/>
        <property type="gene ID" value="AciX9_4415"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4415"/>
    <dbReference type="HOGENOM" id="CLU_1376463_0_0_0"/>
    <dbReference type="OMA" id="ECIFDTA"/>
    <dbReference type="OrthoDB" id="2123065at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="21522" checksum="F94E15C0D7420433" modified="2011-04-05" version="1">MKELGMFWWAFAVRGGGAILFAGFLLYSGSFFGTIFFDPIMFVVLALVLGFYILSNGILLGVASGYAAEHQVDIWQFLLAECIFDTALGTYVGLTLLLSSESLAWLAGLHALGTGCFLAALAWKLRANKAYSGLLGVAGFIAFCAGLAFVLYRQAATRTATHWLGGFELFYGVVVFVFAEGLHRHHVPLLRGESAEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I1</accession>
    <name>E8X7I1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cna B domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71415">
        <property type="protein sequence ID" value="ADW71415"/>
        <property type="gene ID" value="AciX9_4469"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4469"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="ERMTHRT"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230319" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="424"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1146" mass="121809" checksum="577ED9EFFFE18B1D" modified="2011-04-05" version="1">MRRIPFFVPLITMTLAAGSSFAQTTSGDIAGTVKDASGAVVPHASVTVKNEETGVTVNVTAGNSGDFHASNLLPGKYDLAVSAPGFQPSRLNGVLVELNKTSTSDVSLSIGTSTTVEVVADAGAVIDTTTTNLSQTFSNVELSNLPTTSTGFGVINASLLSPGVASAGGIGIGTGPSVGGQRPRNNNFTIEGIDNNDKAVTGPLIYIPNDSVGSFTLITNQFSPEFGHSSGGQFNTNIVSGTNTFHGKLYEYFQNRDLFAGLGSQASKPALRPRYDNNRYGAQLGGPILHDKLFFFANFERNSIGSNPSLFSCVPTAAGKATLATLTNNGFSATNLQQFLLYTPAANVTGANGAGIDAGADAACGNQASGPQSLTVYSGTALNSATGLYASGTPTVIPLGNYQTTGAAPSDFDVLTTSVDYTITPKDSFRGRYVYNRLTSTDTGAGTVPFEQFYTTAPNRYQLIALSEFHTFTPNLTNELRIGFNRHSNTITAGNFTYPGLDSFPNFYYGDLGQFNLSLGPDSNAPQFTIQNLYQLTDNISYVKGKHDVKIGFDGRKYISPQGFTQRARGDYEYNGLTEFLHDLAPTSFGERSTGNLTYYGDQTALYGYGNDTWRLTPTLTLNYGLRYEFTSVPVGERAQALNANASVPGLVTFQAPKPAYKNFAPRAGINWAPDEKTSVRAAFGIAYDVLFDNLGTLSFPPQYSSTNDVGNVGNPQPGDPNFLKNGGLPAGTGGILTFANTPTGIAAERAATAAFLPNQVTPYAETYTLTVQRTIASNYTMEIGYIGTRGIHLPMQDQINVQPRVTAANQLPTSLTGATTVTAAPGASTLAKIQALSNIVPAWNAAGFTSKITSYQPYSSSNYNAGIVNLTRRMSHGLSANLSYTYSKTMDDATAEVFATTLTPRRPQNSQNIAADYSRSALDRTHRATLAAVYDLQLYKHSNHYLLRNGVGNWTISPIYTYESPEYVTVLSGVNSNLNGDSGNAIDRTIINPNGAASHTTSSTVHAQYAANLAGLCGVGVTQCAANTVGYVADNPTAYYIQAGVGTLPNAPRNSLATRPINNFDVAAYKRINFRERYSFEFGAQAFNVLNHAQYTPGTVNNVNSTSSTGADLPYQTVGNAFFAQPGKVFTNNGRTMQLSGKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L1</accession>
    <name>E8X7L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4501</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4501"/>
    <dbReference type="EnsemblBacteria" id="ADW71445">
        <property type="protein sequence ID" value="ADW71445"/>
        <property type="gene ID" value="AciX9_4501"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4501"/>
    <dbReference type="HOGENOM" id="CLU_699736_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="44007" checksum="5EE5181432377A26" modified="2011-04-05" version="1">MTIDPTLSASDSSRFNFPALCYALLPALFALRYVNTPPDLRTYGPSHWFLNYHNGFVRRALVGQVFSHFNYLSWRSIFVVEALILGIVVVCTYLVFRSMLFGTLNERRFSAFLLAAPAFLPHLAYMGGEMDNFLYMALLAGAFCLMRLRSNTGLLAVTLFSALGLVLHEGFLLMFYPLVLVLIIELIHQRRLKPAAVGIHLAVIASCFLSILHFGKMKGLEAEWVSRAQARTDMPIERTVFVALHNSLGEQVHFALTHYTISLVARVALTLLMCIPYEVVLWRLLISVIEGRGYSIGLQRTVCCLFLVPLLLIPLGHDAMRWIAALCINISLYMLFLYQTDNRHGEGSGGMRALLANWNAAPAGMATFLYLSVLGPWGLAGNRLFANLANLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N6</accession>
    <name>E8X7N6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">AciX9_4532</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573189.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4532"/>
    <dbReference type="EnsemblBacteria" id="ADW71470">
        <property type="protein sequence ID" value="ADW71470"/>
        <property type="gene ID" value="AciX9_4532"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4532"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_8_0_0"/>
    <dbReference type="OMA" id="HAPENDA"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="14974" checksum="A8DB7CC36F55C903" modified="2011-04-05" version="1">MFLLDTNVISELRVGKANPSAAVRRWAASIPGNQLYLSSVSILELETGVLLMERKDTQQGQMLRCWLQGVLKEFSSQVLPFGSTTAVLCAAMHVPDRRPDRDAMIAAAAKEHGFTIATRNTADFDNCGVQLLNPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X5</accession>
    <name>E8X7X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4629</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573278.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71559">
        <property type="protein sequence ID" value="ADW71559"/>
        <property type="gene ID" value="AciX9_4629"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4629"/>
    <dbReference type="HOGENOM" id="CLU_911428_0_0_0"/>
    <dbReference type="OrthoDB" id="2169394at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="32456" checksum="0DDE65D60B5B4CC0" modified="2011-04-05" version="1">MALLAMFQAPAQGVNWLSVFAQNLTNLTTQNGGVLTSVGMSLLSFVAIMMLVQMVISINTANWTISFRPQSVDAGTVMRFMLRLGFCALLEHFWVNPFPGASFGFNHLFSYLAEALAQVLDQTSLNTLTSLLREASTKMDTPSLTAPLELLCYMVVQAILGVSSAILFLINISSFILYGVSALFGPVFIPLYLTNSFRSKFFQYIDVLIGFAMIRAVAAAFLFVWAGFLTTFLQQTFNGDYSIAMWLANLVPVITMFVAFIFNMLFIPSLTQAIFGGAAGMAGRAESVGSQLIALVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV58</accession>
    <name>E8WV58_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0159</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578561.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0159"/>
    <dbReference type="EnsemblBacteria" id="ADW67233">
        <property type="protein sequence ID" value="ADW67233"/>
        <property type="gene ID" value="AciX9_0159"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0159"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084253_4_1_0"/>
    <dbReference type="OMA" id="KTPDADW"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="19328" checksum="821169E92AD5D4B7" modified="2011-04-05" version="1">MSAIDTMLTRNKDFAAHEKSAGTLMPSLPEAMPNVKALVITCADMRVDPAHVLGVESGEAIVLRNIGGRITPGLVEQIGLLGRIGQVAGAAPAGGGEFHIVILQHTDCGITRLAGDPALLAHFFQIQESEVASKTVLDPHNAVAMDVASLRAITALPASWMISGLVYDVATGLVEVVIPPAPLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV82</accession>
    <name>E8WV82_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ordered locus">AciX9_0183</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578585.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0183"/>
    <dbReference type="EnsemblBacteria" id="ADW67257">
        <property type="protein sequence ID" value="ADW67257"/>
        <property type="gene ID" value="AciX9_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0183"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_2_1_0"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="47"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="27929" checksum="ABCF8109129BB996" modified="2011-04-05" version="1">MTVVPTLSPSNLLAESGLRPELLAQLTHVRALLAEELAAAPGDNEACLTCSFQAEDVLLLKLAQELRPNIPVLFLDTGYHFAETYAYRDRIAAEWNLNLTNLLPVKTVAEQEAEFGLLHQTAPDRCCGLRKVEPLFSAVANYKVWLTGLRREQARSRTALEEVADFKLPSGVTVRKLSPFADWTTRDIWQLCAAFEISLLPLYDAGYTSIGCEPCTSIPTDPNDPRSGRWAGKKVECGIHIQADEIQPAGQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH2</accession>
    <name>E8WVH2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579743.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1360"/>
    <dbReference type="EnsemblBacteria" id="ADW68420">
        <property type="protein sequence ID" value="ADW68420"/>
        <property type="gene ID" value="AciX9_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1360"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="VGTLGKQ"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27503" checksum="CFCEECF2D5DD53BD" modified="2011-04-05" version="1">MSARFTGKVAIVTGSSSGIGQSIAVRLASEGASVVIDYHSNPEGAEETQKKIAAAGGGKTITVKADVTIMDDVKNLVEQAWQQLGSCDILVNNAGVEKHAPFWEATESDYDLVLGTNLKAPFFLTQRFVQKLMEAKKPGRVINISSVHEDMVFPNFASYCAAKGGIRMLMRDLAMELGPLGITVNNVAPGAINTPINASLLEDKPKLNALLNNIPLGRLGTPEDVASLVAFLASDEAAYVTGSTYFVDGGLIRNYKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI7</accession>
    <name>E8WVI7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdh</name>
        <name evidence="8" type="ordered locus">AciX9_1376</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. MDH type 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579757.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1376"/>
    <dbReference type="EnsemblBacteria" id="ADW68435">
        <property type="protein sequence ID" value="ADW68435"/>
        <property type="gene ID" value="AciX9_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1376"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_2_1_0"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00487">
        <property type="entry name" value="Malate_dehydrog_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01763">
        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="147"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="32545" checksum="6FB47F9413117241" modified="2011-04-05" version="1">MRKKVTIVGAGNVGATAAHWLAAKELADVVLLDVAEGIPQGKALDLLQAMPIEKRDVSIVGTNDYADTAGSDIVVITAGIPRKPGMSRDDLLNTNSKIMSDVVSKVVEGSPNSILIIVSNPLDAMAQAAFKKSGFPRERVIGMAGVLDSARFRTFIAEELQVSVENVTAFVLGGHGDTMVPLSRYSTMAGIPITELIEPAKLKELETRTANGGAEIVKHLKTGSAYYAPSAAAVEMVEAILKDKKKILPCAAYLTGEYGINGLYVGVPCKLGAKGIEKIIEIKLTADEQAALQKSADAVKELCTVIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP7</accession>
    <name>E8WVP7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2546</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580891.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2546"/>
    <dbReference type="EnsemblBacteria" id="ADW69576">
        <property type="protein sequence ID" value="ADW69576"/>
        <property type="gene ID" value="AciX9_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2546"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686560_0_0_0"/>
    <dbReference type="OMA" id="MIERNIA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="401" mass="43408" checksum="6A7259C27D3FBD45" modified="2011-04-05" version="1">MATEQIVNVAEMDFSALCRAVADASPMPMAGLGGSLHTLRYVNLAFCLLTGKSKDELLGTAFSSIAHCPDECMLLLDRVAKTGLADSHTGQEHNGIHPLYWSYAMWPLRGANQNHHGIMVQVTEAAQFHQDAVAMNEALLLGSVRQHELTEAADLLNVQLQAAIIVAKNAEAALIGSEKLAFAGRMAAVLAHEINNPLDAAMNLLFLAQTTGETPSAIRQYLETADGELKRVAHITRQTLGFYRESSEATTFLVVTLLNSVIDLLQAKRVSTQVIVEKQCDDLLQITAVFGELRQVISNLMLNSLDALGEGGRVTLRASTSRDPLNGSARIRITLADSGQGIDAAVLPRIFEPFFTTKGSIGNGLGLWVCKQIIEKHSGTIKVRSRTDDRHGTTFSLVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT5</accession>
    <name>E8WVT5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3693</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582003.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3693"/>
    <dbReference type="EnsemblBacteria" id="ADW70694">
        <property type="protein sequence ID" value="ADW70694"/>
        <property type="gene ID" value="AciX9_3693"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3693"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_6_1_0"/>
    <dbReference type="OMA" id="WEKWVFL"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="179"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="32717" checksum="0E7CAA26EBA8D250" modified="2011-04-05" version="1">MRILIIGTGALGGYFGARLLAAGRDVTFLVRPARIPQLATSGLNLTSPHGDLHIPTPPTITADTLASTYDLILLSCKAHDLTSSMDSFAAAVGTTTAILPLLNGMAHMDALDARFGRQHVLGGATDISAVRDPDGLIRHLNTLDHLLFGDRDDPSGPRITAIAAALTVPGFGASLRPVILQDMGEKWVAISTGAGMTCLMRATIGDIVAAGAAPLVNQLMLEAASIVASTGYQPTQDFLAVTLAKFTQPGSLFTASMLRDLESGAPIEARQIIGDLLTHGRTANLPTPLLEVVNAHLRCHEIRQQREATNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX0</accession>
    <name>E8WVX0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3728</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582038.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3728"/>
    <dbReference type="EnsemblBacteria" id="ADW70729">
        <property type="protein sequence ID" value="ADW70729"/>
        <property type="gene ID" value="AciX9_3728"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3728"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_0"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="255"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="39265" checksum="FBEE7E5E8A758D85" modified="2011-04-05" version="1">MNNWTEIDAAALTANYKAIQRVAGAEVLAVIKARAYGHGAERCAPILVRAGARWLGVTCASEGQQVRAALDHAGLEADILVMSGSLPKDVPAIVSAHLIPVIWTTDHIDLLAGIGCRVHVEVDTGMGRQGVRPGQDLATLLARISAAGLRLDGLFTHFCSSEVANSNLTLRQRALFEAAVQQTVTAGLTPAWLHAANSSAVDNETPEPSSGDWLTTLAAAAGSQTMVRTGLALYGYCLPIEGGALHHLSPALQPVLTWKARILAVRDLAPGDTVGYNATFIAGPAMKVALLPVGYADGLRRELSHPHGWVMVQGHPAPILGRISMNLTVVDVTAIPAASAGDEATLLGPGITAEDHARLARTISYEILCGIHPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY6</accession>
    <name>E8WVY6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cna B-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3745</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582053.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3745"/>
    <dbReference type="EnsemblBacteria" id="ADW70745">
        <property type="protein sequence ID" value="ADW70745"/>
        <property type="gene ID" value="AciX9_3745"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3745"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NTEWIRV"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233417" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="493"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1181" mass="125250" checksum="C31F4957F55231D9" modified="2011-04-05" version="1">MKKVLGLLAVSLVCTAMGLGQSQNGNVAGTVTDPSGAVVAGATVTVINVATGATRTTVTTGAGAYNIEGLPPQDYKVTVTAPGFGTTSTNTFNISVGSSNTVNAKLSVDATNVQVEVAANSLAGINLENAENSQVVNTQQLLELPTEGRTPYAFVVLSGNAAADPSATSRGVGVNLGGARSASTEILLDGIENTSLFSVGVATFVPVDSVQEYRIVTSNYGPEYGRASGGVVNVITKAGTNAFHGTAYEFFRPSTFASNSYYNNANAIPQHRFDRNNFGFAVGGPIVHDKLFFFNNTEWTRVRSSNVTQFYIPTSQFIAASASSTQAFFQQFGTVSGTPTGKILTLGQIGGAAGSVSSAFATDRAALELAKPGTFNDSTPILQQVNVTVPADAGGGVPQNTYNIVGRLDFNLSDRTQMYGRYVLYNSVTPSGTGNVSPYAGYSTGTTTKSQNLVYGITHTFSNSLVGQFQIGLLRFNNNQPLGTNPAGPTLFVSSAAAPSIANNSLVFPGYSEGNAANGLPSGGPQNNIVLSPTFTYTKGRHSITFGGQYSYIRDNHTFAIYENAQESLVSSTGTTDTINGVKVGALTNFVNGVTDYFQANLNPQGKFPCTKDLITGLQNVTAACTLTTPIAQPNFSRSNRYQEGAGFVNDSWKATPRLTINAGLRYELYGTQHNKNSALDSNFYFGTTGSLQDRVRAGKILQVNQAAPAGVQNPGGKLWNTNYKQFAPRVAFAYDLTGDGKTSLRGGYGISYERNFGNVTYNVALNPPSQLAISFTNLDVGAQIPISTGVLGSFSSGSGVSKAIPQGTVRAVDPRIKPAYNQFYTLVLERQINNTFAAGLAYTGERGIHNYSIANYNRSYYGQVYEGDAAKYAPSGAVNTNRLNPQFTSINVRGADGDSYFNSMNANLRGTNLYKTGVSLTANYTYAHSTDNTSSTFTDGQSNGDVGGVAYFDPYNHAIDHGNSDFDLKHRIAVGFVWQIPSYGATGYKRAALGGWEIGSIFTAATGTPFSMYDCALPAVTACPRARFLQTPNYQRVRPSIGGGAPDKFDYIDFPARYLASGALNNAAYGSYVDPKIGAADLPTIVNGMDTFPGGMSARNAFRGPGTISFNADVNKSIKFTERYSLQLRAELYNVLNHANAYLNLSGANDVSQNSFISTYKNGPDQGANRQLQLAAKIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW10</accession>
    <name>E8WW10_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0242</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578644.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0242"/>
    <dbReference type="EnsemblBacteria" id="ADW67316">
        <property type="protein sequence ID" value="ADW67316"/>
        <property type="gene ID" value="AciX9_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0242"/>
    <dbReference type="eggNOG" id="ENOG5033C26">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377533_0_0_0"/>
    <dbReference type="OMA" id="QMKVNAA"/>
    <dbReference type="OrthoDB" id="1623452at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230360" evidence="1">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23299" checksum="0B243B4ABFC4DF71" modified="2011-04-05" version="1">MKPAQRFLILLAAVLLLPALSARAVEVRISAQALERTLNHQLFKTPGPPGLPNRYYLRGKPTGGCSVFADNPQISFINNAPDDPSSVPRMVVKIHTHANFGASIRGHCIGVWINIESEVSFIPEAEDESVGFHDARIEHLSGSKELDALLLPFLSKKMPSEMKVNAANLLRTLLVRSPDSTGYVLTLDALNLHSMKIESQTLVVDLDATIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW31</accession>
    <name>E8WW31_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrothymine dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0263</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578665.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0263"/>
    <dbReference type="EnsemblBacteria" id="ADW67337">
        <property type="protein sequence ID" value="ADW67337"/>
        <property type="gene ID" value="AciX9_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0263"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_4_2_0"/>
    <dbReference type="OMA" id="MVPCVEE"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044512">
        <property type="entry name" value="DPYD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="PTHR43073"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="52872" checksum="B3A0458F9FADE6A1" modified="2011-04-05" version="1">MPTLECNFAGIKCLNPFWLASAPPTNCGEQIMRAFDAGWGGAVWKTIGEPITNVSSRYSSIDWAGQRMMGFNNIELISDRPIATNLREISEVKRRYPKHVVIASLMVESKREVWHDMVAQAEDAGADGLELNFGCPHGMSERGMGSAVGQVPEYAEQITYWVKERARTPVIVKLTPNISDIRMPARAAKRGGADALSAINTINSITGIDLDTFEPRPMVDGKSSHGGYCGPAVKPIALNMVQQIMADKDAMLPLSGIGGIGTWKDAAEFILLGCGNVQVCTAAMHYGYRIVEDMADGLLEWMAAKGFETIEDFRGLSLPNVREWKQLNLNYRIVAKIHADKCIGCQLCYTACWDGAHQCIHLDRAEGGAEMVPAGTDPRHTHHEANPHGKPTPAMVLGLSAKTITTTPIPKLDLSGAGVNSSVTPIARIPRVDEDECVGCNLCSLVCPVEDCITMERVETGLPFQSWEERSAAGLAPAGGSEVGIAEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW74</accession>
    <name>E8WW74_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1398</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579779.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1398"/>
    <dbReference type="EnsemblBacteria" id="ADW68457">
        <property type="protein sequence ID" value="ADW68457"/>
        <property type="gene ID" value="AciX9_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1398"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015182_6_1_0"/>
    <dbReference type="OMA" id="TLEWQRD"/>
    <dbReference type="OrthoDB" id="1259602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="214"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="458" mass="45704" checksum="DCE94B0FA28D0416" modified="2011-04-05" version="1">MGTVGLSFGSATSGAGFDVATTVSSILAIESGVETPWKARLTSLQSQDAAFSSLGTQLSTLSTSLSSLTSFDGLFAAKQGSSSDTDVLTLTSASTSAVAGSHTVVVNNLAQTSSSYSDQITSASDTLGGSLTIAIGSGTQTITLGSSINSLSTLAAAINSGSYGVAASVVTSTTGSRLSLVSNTSGAAGEATITSNLTDTTTSTAVGFTEGQAGKDASLTVDGLATTSASNTVTTAIPGVTFQLLSAPAGSSNTSVQIQITNDNSSLESAVQSFVTAYNAVNSSIAAQEKNDSTGTAEPLYGNPTLSLLQTQLSQALFSGAASGKVSSITQLGLSVGSDGSLSLNTDTLDAALNSNYSDIAGFFQASGSFGQSLTTTLNQLGTNSTTGAISLALAQNSTEELGINTNIANEDAHIATESTALTAELNLANQELQAIPSQIDEVNKLYSAETGYNQTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH9</accession>
    <name>E8WWH9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein AciX9_2618</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2618</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580958.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2618"/>
    <dbReference type="EnsemblBacteria" id="ADW69643">
        <property type="protein sequence ID" value="ADW69643"/>
        <property type="gene ID" value="AciX9_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2618"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_0"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="35369" checksum="CF7B5A7336D0AA63" modified="2011-04-05" version="1">MIRKTATKTTAKVAKAAKKVSGGARKVAKVVAGDGELVILTGMSGAGKASALKALEDLGYYSVDNLPLELIPQFAELVRQSAENRRAALVVDVREGSRLELFPGILRKVKKVLPTRVLFLEASDDSLVRRFSETRRPHPMGRSETVPQSIRAERKRLDPVRNVADILLDTTKFNVHELRAHINAQFEARSEEDKNLTISAMSFGFKNGVPTDADLVLDVRFLPNPHFVPEFRELTGKHPKVAAYVQSFPQTEEFLKKTTDMLEFLLPHYIAEGKSYLTVAFGCTGGQHRSVSIAEEMKKRLEGVGYRVKSMHRDMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN1</accession>
    <name>E8WWN1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3776</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582084.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3776"/>
    <dbReference type="EnsemblBacteria" id="ADW70776">
        <property type="protein sequence ID" value="ADW70776"/>
        <property type="gene ID" value="AciX9_3776"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3776"/>
    <dbReference type="eggNOG" id="COG2071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030756_2_1_0"/>
    <dbReference type="OMA" id="PTYHHQA"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27087" checksum="55D7108545789565" modified="2011-04-05" version="1">MPVRIAIPTPTSTDPAYNSLNWKDYAAAVRACGAEPVEIPLNISPKAIAELANTCQAILLPGSPADVTPEKFGQERDPATSPADLPRENVDELLLQDAHNLYKPILGVCFGCQILNVWRSGTLLQDLTILPVNHSAGRSVAVAHTAEIAPNSLLAEIAGPELEGTRLPINSSHHQAIGIPGDGLRVSARCPQDGVVEAIEGGQSNSSHFVLGVQWHPERTFATNPVSRLLFERFVHEATTWTPREILTSVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS8</accession>
    <name>E8WWS8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578734.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0334"/>
    <dbReference type="EnsemblBacteria" id="ADW67406">
        <property type="protein sequence ID" value="ADW67406"/>
        <property type="gene ID" value="AciX9_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0334"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_2_4_0"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24324" checksum="DC8321D8692170A9" modified="2011-04-05" version="1">MKISSVGEYGKQLTRLGAVNCFLVLEDDGYTLIDGNLKGTEDEILRAAGDVPIRRILLTHPHVDHVGSVDALMARVAGLKLLASERSIPILQVPPDLSLRPGEVGPIRGGTPGIATKVSQTVAEGDRLGSLLVIDTPGHIHGHQAFLDERDGTLYAGDEFGSLGKFNITGFMPWWFPLKAFSNRDQAKDTARKLQGYPVQRVACGHGRVLEGGRELVQGAIDRAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX06</accession>
    <name>E8WX06_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1514</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579886.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1514"/>
    <dbReference type="EnsemblBacteria" id="ADW68567">
        <property type="protein sequence ID" value="ADW68567"/>
        <property type="gene ID" value="AciX9_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1514"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_6_2_0"/>
    <dbReference type="OMA" id="DHFIDNG"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="154" mass="16798" checksum="C27A83F7C8CCA83E" modified="2011-04-05" version="1">MPPESHLPAGKTLDEQASHCFGCSPINPIGLQLTFTLTTEAENITATATVQLTRNHEGPPGYLHGGIIATLMDEAMSKLNRPLNLIAMTRNLEVDYLRPCPIETPLTLTAHHLHREGRKLFHSATLTHPDGTVLATAKGLFLAIDPALLNRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC5</accession>
    <name>E8WXC5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0386</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578786.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67458">
        <property type="protein sequence ID" value="ADW67458"/>
        <property type="gene ID" value="AciX9_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0386"/>
    <dbReference type="eggNOG" id="ENOG502Z971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688431_0_0_0"/>
    <dbReference type="OMA" id="CGREMWE"/>
    <dbReference type="OrthoDB" id="662841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="123"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="404" mass="44883" checksum="FD04D6F62A0064CC" modified="2011-04-05" version="1">MKLPIIKNFHLGRAQQLAALLLLIFLGECLYVVAHQHPTSDDYRYARCGREMWERPSPLAGYFTTCGNLNGDGTFAYRVASFPLTAQRLFLLATDKLRKPADRLYAGGTLNGSTWEARHQITSTKWLMHLPFCLFAMWLGGGLWWVSRRLFGNEGGFLALALYCFCPAVIRYAVTPNNEILAMWGLYGTIYTAMGVAHAMQGPRSKWRPRILLLALAMGLTAAAHLTAAMFGFLAALILMFYLAERRRSAVLPILTWSAIGTLAILFAAFSFRPAPFSYVFTGGGGRFWFSLDGLHTMLADPGNWPILLGAAIALVLYAVIPRSRYFGNTAPLLMFLAILPLMTTQVFSAPWLWALPFLLTFLGGVFADVLESKHRKLFLATTAMLLLTQAAICLKLLPTLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF3</accession>
    <name>E8WXF3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578814.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0414"/>
    <dbReference type="EnsemblBacteria" id="ADW67486">
        <property type="protein sequence ID" value="ADW67486"/>
        <property type="gene ID" value="AciX9_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0414"/>
    <dbReference type="eggNOG" id="COG2184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093097_0_0_0"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="24503" checksum="A327A954193F3DE1" modified="2011-04-05" version="1">MELSILDPFGDYESAGYLRNVYGLHDLERVGHLETASFREEVLGATRHLRRISVLRYEDVLETHRRLFLALYPWAGQDRFATAPTIAIAKGGYNNLFSHPAECRLAAEYALRLGQDVKYLRAQAGEVFGYLAHSHPFLEGNGRTILTVFAELTRRAGFYVVWEDIDKREFLDRLTDELLQPGKGIMDQLILPYVRAGALTAEMTARRLRVRFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR1</accession>
    <name>E8WXR1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581071.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2732"/>
    <dbReference type="EnsemblBacteria" id="ADW69756">
        <property type="protein sequence ID" value="ADW69756"/>
        <property type="gene ID" value="AciX9_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2732"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_7_0_0"/>
    <dbReference type="OMA" id="GCALVGQ"/>
    <dbReference type="OrthoDB" id="967266at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="392"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="492" mass="52408" checksum="10BCD0541A97DCD3" modified="2011-04-05" version="1">MRLADVRIELLAGLTSALSLVPEVVGFALVAHVNPLTGLYAAFIICLIAAIFGGRPGMISGAAGSMAVVSAGLVLQHGVEYLFATIILTGILQLLFAWFRLGKLIRMVPHPVMIGFVNGLAIVIASAQLQHFHTRTQTGSEGWMATPALLIMLGLVAVTILVTVLLPRLTKAFPSALAGILAATACAFAFGIHTRTVGDLASIKGTLPTFHLPAVPYDLHTLRIILPYALILATIGLVETLLTLNLIDELTGTNSQPNRESMAQGLGNLIGALFGGMGGCAMIGQSMINLNAGGRRRLSGICAGTFLLAFILFGSRLIERIPLAALVGVMFVVSAETFSWKSLKGFARIPRHDTMVMLVVTAVTVLANLAVAVVAGIVIAALVFAWDHAQELEVTITEEPGSKTYRLKGSLFFASAAQFTSFFQPKFDPAEVFLEFHEARIMDSSALEAVEALATRYREQGKRLHLHGLSESCDKLLRRKDGAGLLLSLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR5</accession>
    <name>E8WXR5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ordered locus">AciX9_2736</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581075.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2736"/>
    <dbReference type="EnsemblBacteria" id="ADW69760">
        <property type="protein sequence ID" value="ADW69760"/>
        <property type="gene ID" value="AciX9_2736"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2736"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_0"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="629" mass="68087" checksum="AC8CDAD2A09AD071" modified="2011-04-05" version="1">MSRILETINSPADVKKLSVAELTMLAAEIRERLIQSVAKTGGHIGPNLGVVELTIAMHYVFDTPTDSFVFDVSHQAYVHKLLTGREKTFHTIRQPEGLNGFMLRTESEHDSYGAGHAGTALSAALGMAVARDMSGGSEHIVALAGDAAFTNGISFEALNNIAAQTKRMIIILNDNEWSIDKNVGAIAEYFHKIATNSTYVTLHDKAAGLVERFGGKAALHVAKRAEEAAKGLVGRGMIFEEFGISYFGPIDGHNLQLLIETFQFLKQQNKPVVLHAITQKGRGFQPAIEGQKKFHGLGPYDPETGETKVPGQKTYSEIFAETLTKLANGNDKVVAITAAMPNGTALDLFRPHHPKRYFDVGIAEEHAVLFAAGMATKGYRPFCAIYSTFLQRSFDQIVHDVALQNLPVVFCMDRGGLSGDDGPTHHGLFDISYLRGVPGLIHMDPMDEDELADMMYTAMLHDGPSAIRYPRGTGPASVVKDQPVALEIGKAEVLQDGSDVAVFALGAMMGEGRRLVGLLEAQGLSVALVNPRFAKPVDAECVALYGRRCGLLITLEDHVLDGGFGSALLERVNEQELAVPVVRVGWPDQFIEHGKQDDLRKKYGLTAEGAMSKAAGFVGKIVGERLAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU4</accession>
    <name>E8WXU4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2765</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581104.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2765"/>
    <dbReference type="EnsemblBacteria" id="ADW69789">
        <property type="protein sequence ID" value="ADW69789"/>
        <property type="gene ID" value="AciX9_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2765"/>
    <dbReference type="HOGENOM" id="CLU_1584167_0_0_0"/>
    <dbReference type="OMA" id="WFHIYRG"/>
    <dbReference type="OrthoDB" id="2147822at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="18638" checksum="9B687430AEF813B9" modified="2011-04-05" version="1">MRLTFALIPLAFLAGCTKPAPTPAPAQEATETYHYPPRPTVPAPPIKLFHQDEDTLTLTTIPNATDDQVAAILWQLHDTFRAHTFAALHLPQTFIDARHPKIWFHIYRGPKCANEKFTHGKYPCGAKYNGAGDYTLGSLNNPNYEEAALRHADGSETALWNPEAPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY5</accession>
    <name>E8WXY5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0452</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578852.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67524">
        <property type="protein sequence ID" value="ADW67524"/>
        <property type="gene ID" value="AciX9_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0452"/>
    <dbReference type="HOGENOM" id="CLU_2825084_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="6178" checksum="48B89DA70666D639" modified="2011-04-05" version="1">MWAFDGGLKAPSNPNGNGNGNGNGNGNGNGNGSGNGSGSGNGSGNGSGNCLATAWLGESVLSHSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ3</accession>
    <name>E8WXZ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578860.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0460"/>
    <dbReference type="EnsemblBacteria" id="ADW67532">
        <property type="protein sequence ID" value="ADW67532"/>
        <property type="gene ID" value="AciX9_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0460"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033063_0_0_0"/>
    <dbReference type="OMA" id="WTAHEWL"/>
    <dbReference type="OrthoDB" id="1841091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="497" mass="56440" checksum="E6F7756A70A75AB4" modified="2011-04-05" version="1">MSDDSIASIDHAAKSPVSTRSSPYSLLLAALTIAAIVFYCVPDSMADPDIWWHLRDAQLQLSCHCFLSHDLFSFTAAGSSWMNHEWLAELPFYAGFHLLQTTGLYLVTLAAIEIIFLGVLWLAYLASGSILPASIATIAGVLLSTVSFGPRTLLFGWVLLVLELLIFALSKRRTALLWALPFVFLLWVNTHGSWLIGIVLFTLFVASSWITFHNGAIDAAPDPPDTRMRLIKVWAVSVLALFANPYGWHLVFYPFDLAFRQKLNIANVEEWKSVDFHSPRGRILFVCLAVLFLLQLLRGRKWTAFELVLLAVGLYSAFTYSRFLFLAAILVGPLLAVSLASAPRISRQRLSPMLRFALIAMILCFIGGRIRTRILTGTKEDSRFPDQSLPFLATFHPQGRVFNEFLWGGFLVWHKRDTPVFIDSRVDIFEYNGTFKDYLDIVRLKDSLALLDRYQIRYVFFERDSPLIYLLKTTHHWKVDYEDNTSSLLERSEAQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY79</accession>
    <name>E8WY79_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1655</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1655"/>
    <dbReference type="EnsemblBacteria" id="ADW68706">
        <property type="protein sequence ID" value="ADW68706"/>
        <property type="gene ID" value="AciX9_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1655"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NMGFFRN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233482" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1162" mass="124307" checksum="6C1804D6ABFC6A56" modified="2011-04-05" version="1">MKVDQVVRRPFHPAKRVMRASLAGTALALAACSTLPGSFSNGGSAYAQNTNATIRGQVLDPSGALVPSATILIVNQDTGVTVFSGQSDSSGTFVAPQVIPGPYRITVSAPGLKQSVTENLIATVAQVTSVNVNLELGQTTETVTVQSKGQELDRSTSDISTLISPAEVQNIPLQGRAVENLLAFIPGVAHGGAGDTPNTSQLSINGSRTLNTEVLLNGVSTIIASTGSPLSLPSSDGVDSFRAITTNAPAEYGRTSGAVISVNTISGTNTYHGNLYFLAKNEAFDANTYFHKETINATTGAITPRSRDRFFQAGGSFGGPVRIPHLYNGRDKTFFFVNFDRTIQPSSTLVTATVPTAAQRTGNLSNALATTDANGNKRTPQTIYQPNGTASLPFTNGQVTGIDPAAAKILALLPLPNTIGTYDPANNRYTSNWTSLQNLTQHTNKIVVRVDEAVTPKDRLSFNVYRYTTQQPQQVTYNSKLLNTTWDCTCNNAWLPSVDYTRTFTPTLVMDLNMGFFRNVVLRNPPGTGLGAASLLGIASLPLDQTPELTNPGISNIGADTNTNQINITNTFTPFGTVTKTFGPHTFRIGGSLRKNEFNSYNPASSPEGSIAFDGSITNHGASGNANTGIADFLLGKIKTGSYEQPQPETGRRNYNYGLFFQDDWRVTTRLTLNLGIRYEYESPLVIANNIYSRIDPATGTLLVAGQNASRSLNIGTPKADLSPRIGLAYSLDSKTVIRAAFGTFYSTIFQNLGGQLAYPGFDNTISYNNLGTAVAQPFSLSQGLPLAAPANLSNPGLALANASAANPYTVAISFNNQQHMSLVQQWNLGFQRQLPLALTLEVNYVGNHGLHLPYVAGENQVPLAAVPAVTLANTSLATQNSLQFPQFKSFSTTNNIGGSNYNALQITVHREFNKRLAVISNYSYAKAEDDASSIYNFSAPNGTANSQYPVDNGARIKDFTVSNIDVKHILNIGVIYTTPGPWWLRNFHISPVFFGHTGLPINITQSNEIPGASQRPNGNPQLLKLANPVANGAALQYFDSATDPNFPLTASGPVYNTINGVRTQIVATGFGNVGRDSNRAPGEVDFDASISKDFKLYKRLGFQFRVDAFNVINHTNFGAPSGSLSVTEVGTAPTFATSSGFGKITSTQPNRTLQLSSRLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY96</accession>
    <name>E8WY96_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1673</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580042.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1673"/>
    <dbReference type="EnsemblBacteria" id="ADW68723">
        <property type="protein sequence ID" value="ADW68723"/>
        <property type="gene ID" value="AciX9_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1673"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_1_0"/>
    <dbReference type="OMA" id="NYIFFGM"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="536" mass="60206" checksum="63B4DA4A59C9151C" modified="2011-04-05" version="1">MLFNSLKFIFVFLPITMLGFHLLGRYGRRPVIAWLALASVVFYAAWNPIFVLFLLGSILINYLAARIISAAPEDSTRRKQLLAAGISLNLLALFYFKYLYKSVLLLNTFHLTHIAPHPILLPLGISFFTFTQISYLVDLAQGQAERQDFLSYLLFVTFFPHLIAGPILHHKEMMPQFGKILPEDQAANLDEALTPVPPSRQFSLKAADVSLGLTWFLMGLAKKVLIADQLSPTADLAFSHFGSLTATSAWTGLIVYSMQLYFDFSGYSDMALGLARIFSIRFPLNFDSPYKATSVTEYWQRWHMTLTRYITLYLYNPLLLGVQRRRSATGKKISRKALTTPAGFTSMVAYPTLVTMLLTGLWHGAGLQFVIFGLIHGIYLIANQAWRHFRQRIHNAPAPPEPKSIQRLAMMIGVYLQVAFALIFFRSESMHAAITFLHDLAGAHGTGSLGSLLEGTLAFALFPVVWFMPNTQQILGQESSAPSLGTTPTILRDPAPRFFPTLRWSPTIPWAVVMAILFFAVLVVLNPKATFLYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE3</accession>
    <name>E8WYE3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2826</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2826"/>
    <dbReference type="EnsemblBacteria" id="ADW69849">
        <property type="protein sequence ID" value="ADW69849"/>
        <property type="gene ID" value="AciX9_2826"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2826"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="DNLTWQK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233489" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="523"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1111" mass="119534" checksum="ABFB8A4D1C977F0A" modified="2011-04-05" version="1">MRKHTYRNFGAAVVCMSVAASVAAHAQTITGSVNGVVTDSTGAIVRDAQVVVHNVDTGVDTAATTNGAGQYSLRFLQIGHYTLTITGAGFKTFKSNTFTLEVDQTAKIDGTLQTGAASDTVTVTSELAPILDTDNSTIASTFSANTVENLPLNGRNFSAVTQFIPGAVTTEPSSMSNQNAIERDTNQGGQVSINGNRNQTNNYMLDGVEMNETINNVIGYNPAPEAIENLTTITSNATAEYGNVNGGDVITVMKSGTNSLHGGAYFYLQDANMNANSWSNNFSGTARQPFTQSIFGGTIGGPIKKDKLFFFADYEAARWHTGGTQVDSVIPTAWRTGDFSAIPTQLYHFVNGVRTPYVNNQVPITNPVATYLFAHPQYYPQPNRTGTGLLGSQNNYTGTYKKYERNDQGDVKIDYTLSRKDSIMARYSQGEASDAQPQAALAITFPTGNSYPFKGIAINEVHTFNSAIVNEFRAGWSRVRWVQGILNDTTGAFASGNSVVGINAPQAIAGFASQDFSGGGQGTTNTTYFTTVGNSPASQNLIDNTFTYGDDLTWQLSKHTLKLGVEILRYQQQNAYAGNDGLLGHEQYTGAFTGSTVPDFVTGQVYYAGIGANSGRSGQRQYRDAAFVQDDWKPTAKLTVNIGLRYEYDQPIYEVNNKQANLDLTTGLYWLAGTAGAANAFGDARALYHPTYTNFMPRFGFAYNPKARMVIRGGYGITNYLEGTGANLRLNFNPPFQSAYQYQAVAATATSPGTPLPTATALPSSFAAATSSNTIRAWDKNIKPAFIQEYSLSGEYQVNNTTSVVASYLGQTGQHLIDARAGNQLTAPGAVAPYVATVGQTGAVVVTETESMMNYNALQLQLRRRQHNGLEYTINYTLSKAMTNNPGFFGTASVSGASAYWQNGYNGHADYGPSGFDSRHNLSGTMVYALPFGRGKQYGGGMNHYLDLAAGGWKISGTVMAFSGLPVTINAPDTTSVNNRASRANHYRHLKITGRTLNNWFGTDLSAQPCIAANGQNNGNCAYGTPNTNQFGTASPGSERAPGYEDVDLTAGKSFTLYHENALEFRADAFNIANIASYLNPDNGISDSNFGQINNTRSIPRTLQLSLHYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG0</accession>
    <name>E8WYG0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2843</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581181.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2843"/>
    <dbReference type="EnsemblBacteria" id="ADW69866">
        <property type="protein sequence ID" value="ADW69866"/>
        <property type="gene ID" value="AciX9_2843"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2843"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_0"/>
    <dbReference type="OMA" id="SSIATWF"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="22291" checksum="C1A6E09E6B7F5BB2" modified="2011-04-05" version="1">MISATLQPEAAAATLDTPAPISIDALHAQYSPRIFRFILASVHDRDLAQTLTQDTFLRAWSSMNSDAQFRGESSEATWLTRIALNLVRDHTRTNRFRFWRSVSATAIEASDLSHALAHPDSTNESRLIASQQLTLIWATVSTLSERQRTVFLLRFVEEFELAHIAEITAMPLPTVKTHLYRALAVIRKAHPLNTKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG9</accession>
    <name>E8WYG9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2852</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2852"/>
    <dbReference type="EnsemblBacteria" id="ADW69875">
        <property type="protein sequence ID" value="ADW69875"/>
        <property type="gene ID" value="AciX9_2852"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2852"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="DFNDHVM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="469"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="541"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="605"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="823" mass="91230" checksum="764E8652C49EE703" modified="2011-04-05" version="1">MRNGQDNSILSHSPKSLTSDILTFASKFSNQMTGPDHNHAHQHLNGMVTPAARIMGTGEMAALIRDFNWAATPLGPIESWSPTLLSTVNLMLSTRVPMQLLWGPDMVLLYNDEFKGFYADRHPAALGQIGRVFWKEVWFSVADELLDVMQNGTAHVHDQTLLPILRNGRMEDVYWSYSYNPIFLPDGSVGGVLNVSQDITQQVLVERHLRDSEARALRILQSIGDAVVVTDANGCVQRMNPVAEDLTGWPIHEAIGMPLAQVFYIVSQSTRKKVESPIDKVKRLGTVVGLANHTILIRRDGSEIHIDDSGAPIRDESGTLTGMVLVFRNIDERYAAEQEREALSARLTQVLEATTDGVVTIDRNWIVTYINAQGARSVANKGNVIGTNHWKTFPEAVYEGSPYVYHYHRAMEQGIPAEFEAYYPDPLDIFAHVTVRPSPDGIVLFFRDVTAERRAERSLKESQLSLARSESELRLITDTVPAFIAYVGLDGRYLRVNRTFEDSFGHPAAYFVGKTLAEIIGPDAPEILRSRGQAALAGHPQHFETVIPTLNGPRTVSINQIPDFDEQGSVRGVVVQAMDITDRKRSDEALIQSEKLAAVGRLAASIAHEINNPLESVTNLIYLARTTDDHDTANEFLETADRELRRAAAITNQTLRFHRQSTSPAEATCLELFESVLSIQQGRIVNSNITLEKRKRAHTPVRCFVGEIRQVLNNLVGNAIDAMHPEGGRLLLRSREAIHHPTGRRGLVLTVADSGPGMSSHTFARAFEPFYTTKDIGGTGLGLWISKEIIARHSGIISLRTSQRLGHSGTVFTVFLPFEAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL0</accession>
    <name>E8WYL0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="5" type="ordered locus">AciX9_0536</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578936.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0536"/>
    <dbReference type="EnsemblBacteria" id="ADW67608">
        <property type="protein sequence ID" value="ADW67608"/>
        <property type="gene ID" value="AciX9_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0536"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_3_1_0"/>
    <dbReference type="OMA" id="LYEYAIG"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="185" mass="21076" checksum="4531B75631EEEF47" modified="2011-04-05" version="1">MAFARPKKREPVGEAELFEYAVGVLSRRMRTVRDLKRLMKARAHEGERGETDMDAVVGRLTELKYLSDDRFAQDYTRLRKENQGFGRRRVQQDLAMKGVGKEIAETTLAAAYDEADEVGLARAYCEKKRIPQPSGVDAQKQTVRVMNRLMRAGYSSSAIFKLFRAWKVEVPEGGDSDTYGEMPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN2</accession>
    <name>E8WYN2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0559</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0559"/>
    <dbReference type="EnsemblBacteria" id="ADW67630">
        <property type="protein sequence ID" value="ADW67630"/>
        <property type="gene ID" value="AciX9_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0559"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_4_0_0"/>
    <dbReference type="OMA" id="TPPPWWI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="538" mass="56884" checksum="A9EBF931AD565C60" modified="2011-04-05" version="1">MSVATPDAVVVPSGSVLDAKLSKSSPGKWGMLVFGAMLVGGIGYIVTKLSGDLSVVHSSSIFPFLLLGLALLIALGFEFVNGFHDTANAVATCIYTHSLEPHVAVVYSGIFNFIGVLMSSGTVAFSIITLLPVELILKVSKGSGFSMVFALLVAAILWNLATWWKGLPASSSHTMIGSILGVGIANQMMMGNSGTAGVDWEQVTKVFKALLISPLVGFAGAAIVFFLFKALARDPRLYKAPEGTAPPPFYIRCLLILTCGGVSYAHGSNDGQKGMGLIMLILVGTVPTAYALNHTVNAKEVQTFAAVSTQVAGALSNYVTPGAVMADPQPELEAFISTKKYEPGVMLALQQQVNEIRNEATQYGALANVPADRQSNVRNEMYLVSETFRLLPKLGPKMNADDMKVVTNYKGFLDKSTRFIPTWVKVAVALALGLGTMVGWKRIVVTVGEKIGKTHLTYAQGASAELVAMCTILAADTYGLPVSTTHVLSSGVAGTMAANKSGLQLSTIRDIAMAWIFTLPAAALLSGCLFWVFNAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT4</accession>
    <name>E8WYT4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1722</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580089.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1722"/>
    <dbReference type="EnsemblBacteria" id="ADW68770">
        <property type="protein sequence ID" value="ADW68770"/>
        <property type="gene ID" value="AciX9_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1722"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045115_0_0_0"/>
    <dbReference type="OMA" id="LIERYHY"/>
    <dbReference type="OrthoDB" id="385681at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038215">
        <property type="entry name" value="TN5-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014737">
        <property type="entry name" value="Transposase_Tn5-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014735">
        <property type="entry name" value="Transposase_Tn5-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14706">
        <property type="entry name" value="Tnp_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DNA_bind" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="477" mass="53976" checksum="ADACC7C4CFBDA052" modified="2011-04-05" version="1">MEPRDEEIGSWLEREVAGCQFKDVRHGKRFVTLLTQLSEQIGGSIPFACQDWAATKAAYRFLSNARVDEEKILAGHFLCTRERFAATNESPVLVLHDTTEFSYHRDDPESVGILQKLASPYAKGGGPGHHITCGILMHSSLVVTTDGLPLGLAAIKFWSRDKFHGANALKRSINPTRIPIEQKESYRWLENVKQSTALLAEPERIVHIGDRESDIYELFSIAHQAGTHFLLRTCVDRLAGEGDHTIADEMREVHVKGLHRVEVRDKKGTVNEAVLELRYRRIRVLAPVAKQKMYPPLMLTVLHAIERNPPKGREPIDWKLVTDLPIRSRKEAIEKLNWYAMRWKIETFHKILKSGCKAEDVKLRTADRLVNLIAILCLLSWRVFWITMLNRTRPEGAPYMALTPTEIYLLDQLVSDPPGATLTGNQLSLYLTKVARLGGYLARAKDPPPGNTVMWRGMTRLTDIQLGFILGTKLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ30</accession>
    <name>E8WZ30_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2922</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581260.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2922"/>
    <dbReference type="EnsemblBacteria" id="ADW69945">
        <property type="protein sequence ID" value="ADW69945"/>
        <property type="gene ID" value="AciX9_2922"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2922"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056320_0_0_0"/>
    <dbReference type="OMA" id="NAADSHY"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="163"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="43615" checksum="A843090D1F990355" modified="2011-04-05" version="1">MPFDLEAIQSALRDAKLDGWLFYDHHNRDPLALRILGLPPDGHVTRRWFYLIPATGTPIKLVHRIETGRLDTLPGEKNEYSSWQELEARLAAMLSGTTTLAMQYSPRNAIMYVSMVDAGTIELLREMGKTIVSSADLVSVFEAVLTEAQIETHYAAQQRIDALLAEAWLEMGRRVRSTGTSEYEMVEYLQQALRDNGLTWQFGPNCSCGPNAADSHYDPTPATSRPIRRGDFVLIDIWGRLDQADSIYYDITWTGVVDREPTEREQLVFTTVRDARDAAIHAVQAAYAAGTPIPGWQADAAARKVITDAGFGDFFTHRTGHNIAIEIHGSGAHLDNLETHDERLLLPNTCFSVEPGLYFPGEFGIRSEVNMITRPGSAVVTGRIQTELLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ53</accession>
    <name>E8WZ53_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0584</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578983.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0584"/>
    <dbReference type="EnsemblBacteria" id="ADW67655">
        <property type="protein sequence ID" value="ADW67655"/>
        <property type="gene ID" value="AciX9_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0584"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701663_0_0_0"/>
    <dbReference type="OMA" id="PWLGHGF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="43350" checksum="EB3C2C4BF73C00D5" modified="2011-04-05" version="1">MISTLTNTQLTRVETGSSALSMAGFVGLYFGVRACLVFLFFQSEPQNGAILSILLNLGLLVVVAFYAAGPGKMNWGAAMRVWPFRFVLLYLGLSLASLAWTEAQSAAVAGGYWLALAADVALVLLVLKADPTAASSDSLLKGFVYGVGLLAVVAWLSPAQADLRIGDDDFLSPNVIGFECAMGTLLCQYLAPQGARWKWLGVALAVTLMRSLSKTSIIAFLVAESFYLLRTNALSRANKIAIVSGALFTAIVFSGFFMAYYTVYTNAGTQAETLTGRTSIWLVAGGLALEEPWLGHGFHSFHSVVPIFGTFQAWHAHNEWLQQFFSYGIAGVALVAALYISLFRQLRRHALDPLGGVFRALLLLVFVRSFVDTERFDISLPLWMITLVSLTLAQTQEAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU5</accession>
    <name>E8WZU5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane chaperone Skp (OmpH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0686</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579084.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0686"/>
    <dbReference type="EnsemblBacteria" id="ADW67756">
        <property type="protein sequence ID" value="ADW67756"/>
        <property type="gene ID" value="AciX9_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0686"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109844_0_0_0"/>
    <dbReference type="OMA" id="ERYNKEW"/>
    <dbReference type="OrthoDB" id="1639563at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234019" evidence="4">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="217" mass="22608" checksum="A658ED5062A869B2" modified="2011-04-05" version="1">MNRNLTLLAALGASLATVPAVYAQAAPAAAPAAVAPAATDAKIALVNFEQVVLASNEGQTVTIATQKKFEPKKTQIEAQAAEVETLKKGLQSAPATLSDEERTSRLRAIDTKEKALNRDAEDAQTSYNTDLQEALGKVAQKLAVTMKTYAQSNGYTILLDVSSQSSNVLWALPSTDVSQAVVDAYNKQSGIAAPAPQAPSAPRPAAARPAAPRPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU8</accession>
    <name>E8WZU8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_0689</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0689"/>
    <dbReference type="EnsemblBacteria" id="ADW67759">
        <property type="protein sequence ID" value="ADW67759"/>
        <property type="gene ID" value="AciX9_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0689"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_1_0"/>
    <dbReference type="OMA" id="MEHEACV"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230117" evidence="10">
        <location>
            <begin position="26"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="12">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="11">
        <location>
            <begin position="212"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="48971" checksum="7B3AB160E7A0D440" modified="2011-04-05" version="1">MRLRPLLLILLAFVALLPLNGCQKATTPTEAAALQAAATDTTAYTLPPDKLAKADALAHTRTAVHFTEDIWGILQLWLILQFGLAARMRNLANNLSKNRWAQGFTFLLQFLILTTILNLPLTLYAHHVAVVYGMSVQHLSSFLFDEFKGFLLTYLFGGLGVMLLFYFIRKFPRRWWIPSALAAMALGVLGIFATPYIIDPLFNRFEPLSASNPALVAQLEKVVARGQGINIPPDRMFLMKASDKVTTLNAYVTGFGSSKRVVVWDTSIAKGTPEEISFIFGHEMGHYVLGHIVQGLEFGFAMIAVGFFIAVHLFQFILRHKAKAWRVHSQDNWAALVVLLFVFSILSFIGEPIGNTFSRSEEHAADVYGEEVVHGLIPDPQATAHQSFQLLGENSFTDPNPSALLEFWTYSHPSISHRAAFAERYDPWAPGAQPKYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X031</accession>
    <name>E8X031_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1881</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580246.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1881"/>
    <dbReference type="EnsemblBacteria" id="ADW68927">
        <property type="protein sequence ID" value="ADW68927"/>
        <property type="gene ID" value="AciX9_1881"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1881"/>
    <dbReference type="eggNOG" id="ENOG502Z8G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609603_0_0_0"/>
    <dbReference type="OMA" id="KGMLAWN"/>
    <dbReference type="OrthoDB" id="1022317at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="PTHR10858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="472" mass="48166" checksum="8D9FE1CD2A13BEEF" modified="2011-04-05" version="1">MAPAKVTKTASGTGTGGSLVRKLGPAAPILLAASSLLFPLHHPAPGAKGPVKTVAVPGAGGSASAAGNTLAGLNCGGTGKTACAQPYPLLAAGHPVDWFFVFKLNAQAFPGCAGGDTRTCPFGGTKQDSDKYAHFSQQFVYASSEAHTLQTGGNECLGTTEQDPVGATYDEIYNGSYHYVVWNDQPYGDPTKPCGVGDSCSSAWAHSKGMLAWNDAGEGMVMQVSTPEWPLSGSAKHARAAGGTLGCLEKDNDVEVSQHFFALRLTEPDLELVLAGLDNASIATDTTNLQVVNNGGPARVSALVSGLVTGPKGTGVVTGMLSTGVEMISKPGKLQVPPWQMVSAELGGVSLHVANWWTLPDIIPNTTASTPIHCWDSSLGPSGAVVSATAGVWNKTSFGLLGGSNPNGNHAKVGVSTSGPAPYVIFGDMNQEGSLNGPDCSPSQNGRGGTFYVMQDADLHTSVSGLLGATAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X032</accession>
    <name>E8X032_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1882</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1882"/>
    <dbReference type="EnsemblBacteria" id="ADW68928">
        <property type="protein sequence ID" value="ADW68928"/>
        <property type="gene ID" value="AciX9_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1882"/>
    <dbReference type="HOGENOM" id="CLU_1553118_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="17647" checksum="AF4B1F53BC1EB1BB" modified="2011-04-05" version="1">MKGVAEMYIGLQGCETCLASNEKLITLKLIAGYGVCGFLGILSFVLLWMVWTGKIDLDALVSEVNGQASVSRFQLVIFTIVIALGLFILTIQDGKFPEISAQILILLGISSTTYAVGKGISYSQPGVLNAAGDQKTVKDISATGAAAIATPDGVAAEGAPNPVAAPAAGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C1</accession>
    <name>E8X0C1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3082</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581416.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3082"/>
    <dbReference type="EnsemblBacteria" id="ADW70102">
        <property type="protein sequence ID" value="ADW70102"/>
        <property type="gene ID" value="AciX9_3082"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3082"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103537_0_0_0"/>
    <dbReference type="OMA" id="DLVWAYP"/>
    <dbReference type="OrthoDB" id="2063459at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18214" checksum="0553F92718B207D5" modified="2011-04-05" version="1">MNKGAGDSASGESESVWDYPRPPRLEASVRRIRIVHAGRVIADATQAVRILETSHPPVYYLAPADVAVSLLRRSSAAGSFCEFKGVAGYWDLIMPGADLVGQVAWSYEQPSPGYSALKGFLAFYASKVDECWVDEERVVPQEGDFYGGWITKNLKGPFKGAPGTRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K6</accession>
    <name>E8X0K6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1911</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1911"/>
    <dbReference type="EnsemblBacteria" id="ADW68957">
        <property type="protein sequence ID" value="ADW68957"/>
        <property type="gene ID" value="AciX9_1911"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1911"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="HAYAIRE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230530" evidence="2">
        <location>
            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="278" mass="29753" checksum="F7FEFCF9FD25AE17" modified="2011-04-05" version="1">MWRLWMRRNVCVGVMAVASLLGSGLGSGLAQTAGVTGAAGAKPMFDAVVIKPNHSGTNNTGVDWDKTTFKAENVTLKILMAHAYAIREGLIVGLTGWQLSDRFDINAKVVEASPDALKRLTDEQNMAMLAGMLEDRFALKVHRETKTAAVYELVVAKDGPKMTVNPKEGELDAETGIRRAPPSSMSSSGNELKATDVSMASLAVYLSKQLGRTVIDKTGLTAFYDLKLKWTPEQAASAEDAGPTLVTALQEQLGLKVQAGKGPVETLVVDHVEEPSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q8</accession>
    <name>E8X0Q8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1963</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580328.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1963"/>
    <dbReference type="EnsemblBacteria" id="ADW69009">
        <property type="protein sequence ID" value="ADW69009"/>
        <property type="gene ID" value="AciX9_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1963"/>
    <dbReference type="eggNOG" id="ENOG5030JUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085951_0_1_0"/>
    <dbReference type="OMA" id="ELPNYLY"/>
    <dbReference type="OrthoDB" id="1829390at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08054">
        <property type="entry name" value="gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021146">
        <property type="entry name" value="Phafe_gp6_head-tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011738">
        <property type="entry name" value="Phage_CHP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05135">
        <property type="entry name" value="Phage_connect_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02215">
        <property type="entry name" value="phage_chp_gp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="24089" checksum="644775B6BF4528A5" modified="2011-04-05" version="1">MPDYQLTIPPVVEPVSLAEAKAHLRVDFPDEDSLIAGFISAAREMSEQKMQRAIFNQTYVLSLDQFNYGDWRSTIPMARRNPLNYTALWEATALRLPMPRLVSVTSITYVDTFGVTQTLDPSLYSVDKSSQPARIVPAPSGSWPTSDYYMPGSVKVTFVAGSYGDGIQVNTCPASIKAAILLVLGHLYENREASTVASLKILPLGVDALLSPYRFYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R7</accession>
    <name>E8X0R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1972</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580337.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1972"/>
    <dbReference type="EnsemblBacteria" id="ADW69018">
        <property type="protein sequence ID" value="ADW69018"/>
        <property type="gene ID" value="AciX9_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1972"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310528_0_0_0"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="947" mass="98722" checksum="5D44ECC6ED97B70F" modified="2011-04-05" version="1">MPTGYTQVTGSSLKDSAGTPIANATIRFAPVNNTGVPISFMAGGGGQTVATPVTATVTNGAFTIQLADTTLTTPVNVGYAVTVVDNLTGEHLLGSGYGCVQPSGATWSFDTYVPNLTALVAVQLGPQGREGAPGPASTTTASLVASHLPALRNLFDKTLATNDLLVNWVDGTTTSQTGLAWFATGYIPVVAGKQYVASLNTFLVSTTIGFAFFDGQLTFVGGVMGCAAGTPVTAPANAIYMRVGSGGNDLVAGHDYDYWKNQFIIVEGAVLPSAYIAFGYEDPATTAVKSAALLDRSLGHQRNRFDPTTATPDVLISQVTGATISVPGNYFTSDFIPVSGLAWAICNQNTLFGIPQSGIAFYDDAFNYMGGTNGVAASTAFAVMAGAAYLRVGMGSTDNENPSILPTVVLVGGSVLPSTLASHGGTDAYSAISNALAVASSSAGSSLSHRGNLFDKRGVTLDVLINYTTGNADSWPGYFATDYMIVLGLSEIICNENTSYAASTLGFAFYDVNKAFMKGVAGVAANTAIAVPAGAAFVRFGMGTSTASDRALILAGAMVMPGALMPAHYQSYGASSAATPQKLRLFDGQKNLFDPSQVTLDHLIDYTSGTSTDVSSSFGVGNFFASGFMPVFGLSQIVANQETDYGAGSFGFAFYDEDFNFISGVNGNAAGTPMTVPVGAFFARVGSGGTVQATAKGWSRQVVLSTFMVLTGSIVPANFIPCSQAAALVPSRFYLQNAAIIGDSITAYGEPNSFPQGNGGPSQYIGYQQPMLAALGANKRVIHAYPGTRMVDVLLSSYAPSQAEIQVCNFLTVFKGTNDYGNTALGVVPMGDPLTSTDNTTFYGAMDLMINTWLGWNPSLDIIFFTPLQRSGGTVANSLGFTLENYATAIITKCRQYALPVVDLYHTSGINQLNIATYVGRSPPPQQRRVCKVYRSPDHCACQPVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X113</accession>
    <name>E8X113_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0811</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0811"/>
    <dbReference type="EnsemblBacteria" id="ADW67879">
        <property type="protein sequence ID" value="ADW67879"/>
        <property type="gene ID" value="AciX9_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0811"/>
    <dbReference type="HOGENOM" id="CLU_1347337_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21508" checksum="43965B679D2DA622" modified="2011-04-05" version="1">MGQVIRMTVVVLVGFFLMLLAPCVIAIVGGREKKEKIAATPVVPVAAAFDEDLDLPVRVPGDMSHLTPVAPYVAETEMAVAPVRRPAMGYQESVPYGAPQRVPRRDRDLKSIVAEAESEAMVAHAMAAQANAAAMAATARAAQARAQAAAEHAVAANKAAMNHAAAAREREERDELDEFLSVEPTWPELTVAVSSDGKSQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X131</accession>
    <name>E8X131_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0829</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579222.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0829"/>
    <dbReference type="EnsemblBacteria" id="ADW67897">
        <property type="protein sequence ID" value="ADW67897"/>
        <property type="gene ID" value="AciX9_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0829"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_9_0_0"/>
    <dbReference type="OMA" id="CRGTFRN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="355"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="49227" checksum="4FFE1F31301714E6" modified="2011-04-05" version="1">MPTQTATQSGCRLTTDLLARFRTVRAATLAFTAPLTPEDLMVQSCPEASPVKWHLAHTSWFFETFVLADYLPGYTPYHPDFHWLFNSYYTSLGDMPAKKLRASFSRPPLDQILAYRAHVDAAIATLLSGEAEAEDEVLRRISLGLEHEQQHLELIATDIKHALFTNPLHPAYLEASAKPWSLIPNLCTFTTFEGGLTEIGLTLDPSDPNAFAFDNETPRHKVYLQPFALANRLVTVADYLAFIDDNGYTRPELWLSEGWSTMRAEGWQAPLYWRRDSATTSGWSVYTLHGFQPLESLLATPVCHLSFFEADAFARWSGMRLPTEFEWEHAALTATTAPRNMLESDTLHPTPAPASEGLQQLFGDVWEWTSSGYTGYPGYRPLPGALGEYNGKFMSSQVILRGGSCVTPATHIRPTYRNFFTPATRWQFSGLRLAKDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X143</accession>
    <name>E8X143_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="9">Kdo transferase</shortName>
            <ecNumber evidence="3 9">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 9">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0841</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0841"/>
    <dbReference type="EnsemblBacteria" id="ADW67909">
        <property type="protein sequence ID" value="ADW67909"/>
        <property type="gene ID" value="AciX9_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0841"/>
    <dbReference type="eggNOG" id="COG1519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036146_2_1_0"/>
    <dbReference type="OMA" id="FIKYEFW"/>
    <dbReference type="OrthoDB" id="1163086at2"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_N" evidence="10">
        <location>
            <begin position="38"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="431" mass="47894" checksum="4C35DBBB5FC1C651" modified="2011-04-05" version="1">MAMLIYSFLLALGLVIASPWWLWRMATSGRYRAGLGGRLGQVPAELRAVVDGKRVVWIHAVSVGEVLAAERLVREMEAALPGWVVAVSTTTASGQKIARERFGAERVFYLPLDFAWIVRRYLRALKPELLVTMESELWPRVLVECERVGVPVAVVNARVSDRSYPRYMRLKALWGPLLRKVAVFLAQGEESAWRLRQMGVESGRVRVIGNLKYDMQVDESRPMVKLLRQMVTGRRVLVVGSLVEGEEAFFRDCLWDFWKKAPDVVVILAPRHPQRFVEAAGVFRKGFRVCKASDMMADSKLPNPPKYLQSLPLVILDTLGDLAGVYGLADVAFIGGSLVAKGGHNPLEAARFGVPVVMGESYENFREMVESMKEAEAIRIVDGAGLGEALTRLMRDDEGMGERGRMFFEGQTGATGRAVEALVELISGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X157</accession>
    <name>E8X157_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0855</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579248.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0855"/>
    <dbReference type="EnsemblBacteria" id="ADW67923">
        <property type="protein sequence ID" value="ADW67923"/>
        <property type="gene ID" value="AciX9_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0855"/>
    <dbReference type="eggNOG" id="COG5042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031475_1_2_0"/>
    <dbReference type="OMA" id="GINTKGP"/>
    <dbReference type="OrthoDB" id="844031at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PTHR38643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="34791" checksum="CA00C0E6E8C849B8" modified="2011-04-05" version="1">MQRIKLVLIAAFEPDWPLNEGPVPGELTLFRQRNNLTQTIPLEAAYRPLLTDGAGTLALATGVGAARAAASVMALGLDPRFDLTNARFLITGVAGATPTQASLASVVLPDYVVDGDLTHELDAREIPAEWPDGFIPIGKTTPYEAPRAARFNNDDGIVFQLNSTLIERAFNLTRNIILEDTPQITERRAQFSPAQSAPKVLRGDELSSSTFFHGRLMSQRATRWVSYQTEGQATYTITAMEDTGILQSLTFLAAAGKLDFNRVLIARAVSNYDQQREDITAAESLAETKVATYSAYRPALENAHRVATAIIQSLDQDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X169</accession>
    <name>E8X169_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0867</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67935">
        <property type="protein sequence ID" value="ADW67935"/>
        <property type="gene ID" value="AciX9_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0867"/>
    <dbReference type="eggNOG" id="ENOG5033ZMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911426_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="33575" checksum="D50FBB2D6B6CECBA" modified="2011-04-05" version="1">MTTQTQAVEAPARFQCRHIHTDGRRCGSPTLRHEHFCYYHHTTRKPIPRADLAARYADQNRNAPFDLPLPEDRASIQLAIGEILRRIAANQLDNRRAGLLLYGLQIAATNLPPQRREAEEPQKSRQQVEEITEHETLGTLAPQSEFTAPKGEKTLEQILTEQWAKDKEEAAEKARLHPPAPERPDYIWSDEEEGLVLKAVAEPGLHEATSPKPAPTKSALIAFIPSYPRNLSSGTSTPYKKLRTLLRTTSATRPKTTCVAISLDLSRVVCSAGSAESPIAGSTPSCVRAISVIPKFAPCRAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X192</accession>
    <name>E8X192_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2001</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69046">
        <property type="protein sequence ID" value="ADW69046"/>
        <property type="gene ID" value="AciX9_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2001"/>
    <dbReference type="HOGENOM" id="CLU_2617041_0_0_0"/>
    <dbReference type="OrthoDB" id="2050548at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8922" checksum="C5C7A2F50930089B" modified="2011-04-05" version="1">MRVLWRAVETITGQSFTRVSIHIDGKRFVDCTFTRCMLGYSGGEVEFKGTILKDCKYLLYGAAREPVFDLQTRRAVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B7</accession>
    <name>E8X1B7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2026</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2026"/>
    <dbReference type="EnsemblBacteria" id="ADW69071">
        <property type="protein sequence ID" value="ADW69071"/>
        <property type="gene ID" value="AciX9_2026"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2026"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688433_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="45291" checksum="9714B4D24A2ECE2F" modified="2011-04-05" version="1">MLVVILPFGLHRSNESDTLNRKQERFTEQHQQEKRPRLKETDKFQGSFGPQSSSPGPWLATILVDALISDQNDESLSKPLLDGYQYQGAIEILASYGEHSRHSLDNAAKQVVDSTPNFPMIGQPNVLSGQEWLEWQRNRPMSLHSYQARLEDAEDAKRVILDAKTAVRGKGKKKPTASTKLTRIKITDEKFNADYNTWFDAAKSNDACAFFETLYHFLVGKTRMVMASENVKRREQADDFQQDFAIEMMAALAAKKIAGERLEKPANYVTRSWTNGRIDANTAISKHDKMFPSVQTGKDSTDEDENYVTKDLVNRRDANEWLRGSKHIEPQRDEDALYLERMAKLPMLDPGLRDATGMHLAGHTQRQIAQVLGITQQAVSKKLVKISSQLQTPRKSEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R4</accession>
    <name>E8X1R4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0916</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0916"/>
    <dbReference type="EnsemblBacteria" id="ADW67983">
        <property type="protein sequence ID" value="ADW67983"/>
        <property type="gene ID" value="AciX9_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0916"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167398_0_0_0"/>
    <dbReference type="OMA" id="GDQGMIR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12435" checksum="93625717F1F7D4B9" modified="2011-04-05" version="1">MSTTNINGLHEQPILPIGDPKAYSSVRSTIEASFSNGRVPDFLKSLDRGGLRIRDFETVLGKGLLGVNTKAEYNQLDNGDQGQIREYYLASLERVSPELRNKFFKLYAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S2</accession>
    <name>E8X1S2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579315.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0924"/>
    <dbReference type="EnsemblBacteria" id="ADW67991">
        <property type="protein sequence ID" value="ADW67991"/>
        <property type="gene ID" value="AciX9_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0924"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_3_0_0"/>
    <dbReference type="OMA" id="AWYLANG"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="22177" checksum="5CF4DD7210D2A767" modified="2011-04-05" version="1">MNLSLTDIPLPIRLRTESPLTDEELLRFCADNDPLRVERDSNGELIVMSPTGTEGGFVESDVALELGIWARQDGRGRMLASNTGVRLSDSSIRAADAAWVSWERLNSLTADQRKGYSPFCPEFVIEVRSESDGLEPVRDRMQMWLANGAELAWLIDPARRVVEIYRMAEETELHENPTSVQGTGPVRGFDLVMARIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T8</accession>
    <name>E8X1T8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0940</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579331.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0940"/>
    <dbReference type="EnsemblBacteria" id="ADW68007">
        <property type="protein sequence ID" value="ADW68007"/>
        <property type="gene ID" value="AciX9_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0940"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_0_1_0"/>
    <dbReference type="OMA" id="VAEQCEK"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="67"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="267"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="43508" checksum="3123F9CFA0D63377" modified="2011-04-05" version="1">MTEFVVKLADERGKVQEQTHAAATAEELRARFTQSGYYVYSVKAKGLLGGDGKKKKVKLETFLVFNQQFLTLIKAGLPILGSLDLLARRQKVLNFRAQLEDVATRVKTGESISSAFEAQGGFPIVYTTTLLAGERSGNLEEVLQRFLDFQRVSLTFRKKLKASLIYPSLLIVMVIGLFIFLITFVVPRFAQLYDQLNTHLPALTVFLLDLGRNAQTYGLYVAAVVGLVGYLIYRWMKTEAGATTVDRIRIALPGVGGIWVKYQVGLFSRTLSTLLTGGLPLVPSLETAARAIDSKQIGLAVFKSVETVREGKGLSVSLAATKVFPELAIEMIEVGESTGALPQMLNSVAEFFEEDVQTNLTAAMSLIEPAILIVMGVVVVIILIALYLPIFSLSAGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X228</accession>
    <name>E8X228_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581583.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3260"/>
    <dbReference type="EnsemblBacteria" id="ADW70271">
        <property type="protein sequence ID" value="ADW70271"/>
        <property type="gene ID" value="AciX9_3260"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3260"/>
    <dbReference type="eggNOG" id="ENOG5033RXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070775_0_0_0"/>
    <dbReference type="OMA" id="RILGFMP"/>
    <dbReference type="OrthoDB" id="1259275at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234096" evidence="2">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="36144" checksum="5686E713B844AED7" modified="2011-04-05" version="1">MRLLAPAALLLAASAACAQQSAAPYSSLPDAPSQLLLAANTPAPELPESSDTPVATGFSSSLAPADIYDYTLYPDGYPQDAAAQAAKQSDQNKKKPGWADEPDLDANGNPIPLNRHQPKRILGFMPNYRSVSVGSAVHPPGWKYNFSVATRQSFDYSSFIFLGITSLTAEAINSHPALGKGVPGFYAYTWRGFLDKTDGTYLGAWFLPSLLHEDTRYYPLGPGHSIAIRALYVISRQGVARTYGGRQTPNIAGLGGKVLTQLISRNYYPAGTSDFGVLATKFAYSAMRDIGFSSIREFYPDIAAHYVRLHHEKAAAQAARDAAAAAAGQSNPATPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X239</accession>
    <name>E8X239_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70282">
        <property type="protein sequence ID" value="ADW70282"/>
        <property type="gene ID" value="AciX9_3271"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3271"/>
    <dbReference type="HOGENOM" id="CLU_1014757_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="31173" checksum="9740E8CF2BC8A505" modified="2011-04-05" version="1">MALSDQGRDIARRVFEVGFGVAVVVAISIISKKTDIHSFVDDTAVGLLTVIATAFILEPFEQKRLTNQLNHKVSEVKAEIKELRSSINAVHGEFADHIDRYTLALRFTNKNLDRDEMPNAWERMLWSMRGNFDATSYVKPSDYMRSYPDLGIAIQEAKVRVAKARIRRIFIVESENELNLIGPHIAKQMAAGVEVSYVLLEEIKQHVQTDKFDTLDFGLFDDSKSVFLWLLNERSVSGGKIELETDQYAKYRGLFDLLCRISHSYRELLALKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H8</accession>
    <name>E8X2H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b/b6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2158</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2158"/>
    <dbReference type="EnsemblBacteria" id="ADW69202">
        <property type="protein sequence ID" value="ADW69202"/>
        <property type="gene ID" value="AciX9_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2158"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_4_1_0"/>
    <dbReference type="OMA" id="AIVLIHM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="7">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="405"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="56605" checksum="3CFBD2B846065E81" modified="2011-04-05" version="1">MSDPRKLKTPAKSSLVRGGYNLYAWFEKRTGLVESALQSAEHPVPENTSSWWYVFGSAATVLLMLQVVTGILLALVYAPSASNAWNVLQVLNHQVALGWLLRAVHGWGSNFMIAIVLIHMAQVFLFGAYKFPRELTWMVGVVLLLLTLGMAFTGQVLRFDQDAYWGLGIGASIASRVPIIGGPLVHMILGGPIIGGPTLTRFFALHVFVIPGLLIALVGLHVWMVLKLGINDWPMPGRIVRKATYEREYHELTERTGIAFVPDAAWKDAVFAAIILASVLLVAVIFGPIGPSGMPDPTIIQTAPKPDFAFLWIYAVLAFLPPSVETPVMLIVPVLAILGMLALPLFAGEGEKHWSRRPIAVLMVVVIALALGIFTRLGTYTPWSPIMDAWTSDPVPQAYLVHRTPLERQGALVFQNKQCRNCHSLDGMGGQRGPSLDTIATRMSEDQLIRQVLQGGGNMPAFGNSLSPAETTALTRFLRTLRGPGEQSPADVPAMQLGQDGESLPAERHGDPSLDAKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I6</accession>
    <name>E8X2I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2166</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2166"/>
    <dbReference type="EnsemblBacteria" id="ADW69210">
        <property type="protein sequence ID" value="ADW69210"/>
        <property type="gene ID" value="AciX9_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2166"/>
    <dbReference type="HOGENOM" id="CLU_036186_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="42385" checksum="AD529D0B884C65DA" modified="2011-04-05" version="1">MRAGMNCLLDVLQGKVGAQSLSDVEWEQAFELAEAEQVLPSFVSTLRRSGLPLSPSIEKRLCGAERQCAIAGFFWSAELRGLLKSFAEAAVPVLPLKGPSLALRAYGEAAFRSAKDLDLLVQRSDHAAAESILLKIGFAPNRHADDYHRQWSRGTTLVELHFDLENPLAFDFKVETAWQRASPGEFQGQPAWHFAAEDELLFLALHGVRHRFERLSHVLDLALAFRAFAPNGSLAVPRADVAPISRLLVLGAELANLLFPEEPMPIVPADNRTKRKMDTLAKSLWQDLLCEPAGQLDWQTQHRFFVETEVCIGGRYWCRIKHMRILLTRTIEADHAFANRLGLMRHWQVALLRPIRLLLRDLKQRRSKPRIRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J1</accession>
    <name>E8X2J1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell surface receptor IPT/TIG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2171</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580531.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2171"/>
    <dbReference type="EnsemblBacteria" id="ADW69215">
        <property type="protein sequence ID" value="ADW69215"/>
        <property type="gene ID" value="AciX9_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2171"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236847_0_0_0"/>
    <dbReference type="OMA" id="CTESISF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234112" evidence="3">
        <location>
            <begin position="37"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="535"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="705"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="789"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="873"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="959"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="1525"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1852" mass="179986" checksum="33ED4DCF2283027D" modified="2011-04-05" version="1">MIHCIASLSGSVLHRIKLSVVWGLATLLLLAGGAQAANAQLSVAVGTTSATQTATVSVTSPAMTASTTASAISVVTQGAAGLDFNFASGGTCAVSTTYQANFECTIKYTFKPQYSGLRFGAVELKSTAGVVMGTALISGVGTGPQPIFPQATVNTLPGTYSQPRSIALDGAGNAYIANFGNANVLKVPVGCTTSACVTTLETFSGPASVAVDGAGNVYVADFNLNEVLKILANCTSECVSTLGGGFNEPIGIAVDGSGNVFVADFANNQVKVIAPGCTSASCVEPLGNGFSNPQDIAVDASGTVYIADYGNSLVKSMPANCNSFVGCTITTLGGGFSSPSGVAVDGNGNVYVGDSGNNAVEVMTPGCTPANASTCVTTLNGTLSGPIGVTLDGGGNVYVADNGNNAIRELPRATAAPLNFGSVNDGGTSAQQTVTLTNYGNLPLTFPVPSTGVNPSFSSGFAVGSVGAGACPNVSAGGSAGTLAANASCALNITFAPLAPDNGAVTGSATLTDNSAGVPGPTQTIALSGTATDVAPVITSISPTDGLPAGGTTVTVNGTILNTITSVNFGGTVTTNFHIVSESQLTVVSPAEAVGVVDIQVQNPDKLSAKTTADQFTYSNTLLNAITFPALANAALGTTPPTPAATATSGQPVTYSSSTPTVCTIAGSAITDLKVGTCTIAASQSAAGHYAAAATVSQSFQVIAAPTVTGVSPSSGPLVGTTVTITGTDFGSGATVSFGGTAGNGVTVISATSLTVSAPAHAAGTVHVTVTVSGATSVTSANDQFTYAPPTVTGVSPSSGITGGGETVNITGTNFGADSQVIFGGVAATSTYKNSGLIVATSPGGFVGTVDVTVTSGGVTSVTNSADHYTFLVPTVTGVSPSSGLPSGGTVVTITGTGFSGDVLPYFGNNVSTEFFINGPTSITATTPAGASGTVDVTIQANGGTSATSAADHFTYGTLPTVTGVSPLFGPPAGGTSVTITGTGFASGATVSFGGKAATGVVVNSSTSITAVAPSGSGSVDVTVTGAAGTSQANTSDEFGYFILVNVGSTSATQTATVTMTTAGTLGAIDVLTTGQPNLDYAFVTGGTCATGTAYAANATCTVKYSLKPRAPGIRNGAVQLIASGGTSVLGTTVITGLATGPAVMYPTNQSLAILGSGFNQPYSMAVDAAGNVYVADFKNNAVKEILAADGSVLTLGSGFASPTGVAVDGAGNVYVADFGHGALKEMRAVGGSVPTSNPQIATLGPGKFIAPLGVTVDGAGNVYLTDAQAGTVWEIVASTGSVNALGTTFSNPHGIAVDAFGNVFVADFGNNAVKEIVGASGAIVTVGPAFTTPNWVAIDAAGDVYVADAATGTVSEMVAVNGSIPSSSPTVLTLGPGFTSPTGLALDEAGNVYIADNGPNTVYKLATATPPSFTFAATSVGSTSAAQSFSLQNFGNEDLVLSVPGSGKNPAITSGFTLNAASNCPLVSAGGSTVALAEGGFCTESISFKPVTAGSDIGSLTFTDNALNVTSATQAISLIGSGGTPTVTAVSPASGPATGGTAVTITGTNFVTGATVSFGTTAATNVTVISATQITALSPAGSVGVADVTVTSGGGTSATVTADRFTYTAIASTITFPALANTVIGATPPVLKATSNAPTPITYSSTTPLVCTVALGVVTDLAGGTCSITASQVASGIYAAATPVSQSYTVTVPLLFIAGSGSVGSLAGNGNITSSATSGGGIGAAVDSTGFVWSIDASGTGISRFTSLGAKASDFTSVGLVGASALAIDGNSQVWVANSNGTVTVLSSVGTAVSTTQGSTTAAPTGIAIDISGNVWITNNAANSVDEVIGGAVPTSPLSTSVTKNTTGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J3</accession>
    <name>E8X2J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GAF sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580533.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2173"/>
    <dbReference type="EnsemblBacteria" id="ADW69217">
        <property type="protein sequence ID" value="ADW69217"/>
        <property type="gene ID" value="AciX9_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2173"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_1_2_0"/>
    <dbReference type="OMA" id="IDVDCTE"/>
    <dbReference type="OrthoDB" id="1739746at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="17430" checksum="AD4376C1B5A0E2FB" modified="2011-04-05" version="1">MLNAPSSIHSLLLKQFSELATSVTSFYALQQGIVEGQSSALPHYSWTGFYMLNPDDPETLVLGPFVGDPTPHVRIPVTEGICGAAVATGETVIVDDVNADPRYLSCSIKTKSEIVVPINVNGKVMDEIDIDSHSPAAFGEDDRVLLQETARIAGSYMEQHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K4</accession>
    <name>E8X2K4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein alpha/beta-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580544.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2184"/>
    <dbReference type="EnsemblBacteria" id="ADW69228">
        <property type="protein sequence ID" value="ADW69228"/>
        <property type="gene ID" value="AciX9_2184"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2184"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_0"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="251" mass="26810" checksum="4D0D2F58DF1DAFFF" modified="2011-04-05" version="1">MLILSVIRQVLDAEENVRIKDGRVDLSSSKLVIDTMDEYGVEEALRLRDSGTGVEVVVLAVGPARCEEALRTALAIGADRAILVETAETLDVIAVSSVVAQVAKNEGAELIFCGGQQADWDSQGLGAAVAERLNWPQAAWTTALKLADGKLSGTHDVDEGSESFTMALPAVVTTQQGLNEPRYPTLPNIMKAKRKELKKEPLEQFGVAAKLKLVSAEVQVKGRLGKILDGKDAVAAAGELVDLLRNEARVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K8</accession>
    <name>E8X2K8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-methylisocitrate lyase</fullName>
            <shortName evidence="3">2-MIC</shortName>
            <shortName evidence="3">MICL</shortName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(2R,3S)-2-methylisocitrate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prpB</name>
        <name evidence="5" type="ordered locus">AciX9_2188</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580548.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2188"/>
    <dbReference type="EnsemblBacteria" id="ADW69232">
        <property type="protein sequence ID" value="ADW69232"/>
        <property type="gene ID" value="AciX9_2188"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2188"/>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_0"/>
    <dbReference type="OMA" id="QTELWNK"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01939">
        <property type="entry name" value="PrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="31706" checksum="07948A2F99857B33" modified="2011-04-05" version="1">MAVESAGARFRQAVKDERPLQVAGAINAYTARMAEATGFKALYVSGGGVAANSLGMPDLGISTMEDVLIDVRRITEVTKLPVLVDIDTGWGGAFNIARTIRSMIKAGAGAVHLEDQVGTKRCGHRPGKEVVAVGEMVDRIKAAVDARTDEGFVIMARTDALAGEGLEAALERTAAYVAAGADMIFAEAVTELSQYGEFKRAAGVPILANITEFGHSPMFTTEELGAAGVDVVLYCCSAYRAMNAAALKVYETIRAEGTQKSVVPIMQTRAELYRFLDYYAYESKLDELFAQKKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P9</accession>
    <name>E8X2P9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3338</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70346">
        <property type="protein sequence ID" value="ADW70346"/>
        <property type="gene ID" value="AciX9_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3338"/>
    <dbReference type="HOGENOM" id="CLU_2409151_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10620" checksum="5D1DC6FBEE016368" modified="2011-04-05" version="1">MYTREDVQGKIALPNTTGWTSLLMTSFRDEMRDRVVRVKVKQAEYDPEDFRTLRSAFDEEIRMYEECLACAEAAIGRLTHLAEQSADLGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q0</accession>
    <name>E8X2Q0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3339</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581659.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3339"/>
    <dbReference type="EnsemblBacteria" id="ADW70347">
        <property type="protein sequence ID" value="ADW70347"/>
        <property type="gene ID" value="AciX9_3339"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3339"/>
    <dbReference type="HOGENOM" id="CLU_2843704_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="6695" checksum="27BF80B19E225A6F" modified="2011-04-05" version="1">MKLVNIGGYHINPAAIAYVSAKTVVSQSPAGRSQQTIIHFIGGGDLQLNLTPGDFAQQLATATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S5</accession>
    <name>E8X2S5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_3364</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3364"/>
    <dbReference type="EnsemblBacteria" id="ADW70372">
        <property type="protein sequence ID" value="ADW70372"/>
        <property type="gene ID" value="AciX9_3364"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3364"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_2_0_0"/>
    <dbReference type="OMA" id="ATWLSCK"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="44114" checksum="AA1041A879D31AC9" modified="2011-04-05" version="1">MLFDVRPRLQTIPPDRYAREPKALSPTARTEESKGRFPMKLTRLIPLVLIPAAAFAQTKVTTAPFGTLPDGGTVQSYTLTSPQLEVKLITLGAHITAIQAPDREGHKTDVVLGYDDLAGYLADKNTYMGSVPGRYANRIGKGQFTLDGKQYQLPLNNNGNTLHGGTTGFDRYNWTAKQIPSGVEFTVVSKDGDQGFPGTLTAHVRYTLAADALKIEYSATTDKDTVLNLTNHTYFNLSGHGEILGEKMMINSDKITPVNSGLIPTGKFMPVAGTPFDFQKPTTIGDRINVTAGPAGQQMVYAGGYDHNFVLKSAAGTHLAARVMDPASGRVLTVTTTEPGVQFYTGNFLDGTYKGREGMVFAKHTGFCLETQHFPDSPNQPNFPTTELKPGQTFSSTTTFRFSTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T6</accession>
    <name>E8X2T6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3375</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581695.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3375"/>
    <dbReference type="EnsemblBacteria" id="ADW70383">
        <property type="protein sequence ID" value="ADW70383"/>
        <property type="gene ID" value="AciX9_3375"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3375"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_0"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="256"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="492" mass="51951" checksum="C9098C059B41F8B8" modified="2011-04-05" version="1">MTFPTGAALDLRETHDTNDHKRYFIEKLGLSERLMERCLGEALSAGGDYADLYFESVTSTSLGMDEGLVKTASQGISVGCGIRVVSGERTGFAFTDDLSSERLLRAARTAALIASGPAKELASGFRHTETPSLYPIAGLSSDADLAAKLALIERADKAARAYDSRITQVRAGINDEVRRILVAASDGTFASDTQPLARLNVMVIAKDSQNTARGSSGGGGRVTLDFFEGTKSPEHFAREAARTALLQLGAVDAPAGEMEVVLGPGWPGVLLHEAVGHGLEADFNRKKTSAFSGLIGQQVASSKVTVVDNGTIANRRGSLNVDDEGVPTQETVLIENGILKTFLSDKLNSRLMGGVSTGSGRRESYHHIPMPRMTNTYMLNGDDMPEDIIKSVKRGLYAVNFGGGQVDITNGKFVFSASEAYLIEDGKVTRPVKGATLVGNGPEALKYVSMVGNDLALDEGIGTCGKAGQSVPVGVGMPTIKLDRMTVGGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X308</accession>
    <name>E8X308_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1079</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579465.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68142">
        <property type="protein sequence ID" value="ADW68142"/>
        <property type="gene ID" value="AciX9_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1079"/>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_2_0"/>
    <dbReference type="OMA" id="KLWGALL"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="33935" checksum="59CD6E251060D894" modified="2011-04-05" version="1">MIVRPRPKAWELPFIIRQSILPRVAPQIIAVALFSCVVIWIERRFPAPFHTWTVAPFTLLGTALSIFLGFRNNSCYDRWWEARRQLGALMGETRSFARTLLTLPSLSSIPVDQARRQRAIRGLIAYTYALMAFLRGIPIPAQVARYGAEPAPGLRSIPDAILRTIAAEYGAMLAASEIDTQIYRDLDDRLLAVTAIQASCERIRSTPTPFAYTLILHRTAYVFCFLLPFSLVTTLGYATPFFCAAVAYAFFGLDALGDEMEEPFGTHINALPLDALARIIEISLLEALGETTLPDPIAPVNFVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X311</accession>
    <name>E8X311_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1082</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579468.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1082"/>
    <dbReference type="EnsemblBacteria" id="ADW68145">
        <property type="protein sequence ID" value="ADW68145"/>
        <property type="gene ID" value="AciX9_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1082"/>
    <dbReference type="eggNOG" id="ENOG5033KAU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160695_0_0_0"/>
    <dbReference type="OMA" id="FLCNAMP"/>
    <dbReference type="OrthoDB" id="1799699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="10827" checksum="44E31867DF8CB54E" modified="2011-04-05" version="1">MNSHHYLAAFFAGLFLANAVPHYVAGISGNRFPTPFAKPPGKGLSSAPINTVWALANLVAGFLLFRVAAITMGDTTTLLVFFTGIAAISIQLSMHFTHKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X369</accession>
    <name>E8X369_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotide kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2255</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2255"/>
    <dbReference type="EnsemblBacteria" id="ADW69293">
        <property type="protein sequence ID" value="ADW69293"/>
        <property type="gene ID" value="AciX9_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2255"/>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071541_0_0_0"/>
    <dbReference type="OMA" id="TWYKRRG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="35286" checksum="F876BCB570A468E7" modified="2011-04-05" version="1">MREWILNQMRRRTRRGPNESESTGKSGQELPTGQLAPLRPTYPDPIERKPEAPKPEPVKPVISRTTELPIDLLPVAAKHAQPEPEGPEGFEPSAPPEGFAPADPEAEKKVVVETQPESLATPPPGPEAVSPKAPRGYVVLTIGLPGSGKTTWYKRRGVSPLSSDMLRTILFDDITDQRYQGLVFSTLRSLLRARLIAKMPWNYVDATNLSPHERRQWIKMAKSFGYEVQAVFFDVPLAVCMERNSKRDRQVTDEVMQKMAERLRPPVFKEGFDKITVVRVKGAPEAPSDTPTLPQPTPEEPNPDAAPTPTQEPQPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X374</accession>
    <name>E8X374_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">AciX9_2260</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580614.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2260"/>
    <dbReference type="EnsemblBacteria" id="ADW69298">
        <property type="protein sequence ID" value="ADW69298"/>
        <property type="gene ID" value="AciX9_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2260"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_0"/>
    <dbReference type="OMA" id="VWAIGEH"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27723" checksum="F589A9F70F5EB687" modified="2011-04-05" version="1">MRKPVIAGNWKMYKTPRESLAFLQVFLPLIENHTRDEVVLFPTMSSLGYVLEAVEGSNVRAGAQTMHWLNEGPYTGQTSPTMLASIHCTHVLLGHSERRIYANETDDMVNWKLKAAIAHSLTPVVCVGETMDKRQSGLTEAVLRWQISCALNGVEREGSQAMIIAYEPIWAIGTGSTATPAQVEEAHKIIRREVAERLGEERAESTRIIYGGSVKPENTAKLMAQPNIDGALVGGASLDPETFCRIVKYATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X390</accession>
    <name>E8X390_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580630.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2276"/>
    <dbReference type="EnsemblBacteria" id="ADW69314">
        <property type="protein sequence ID" value="ADW69314"/>
        <property type="gene ID" value="AciX9_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2276"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_0"/>
    <dbReference type="OMA" id="MYPVISM"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234317" evidence="1">
        <location>
            <begin position="27"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="306" mass="32493" checksum="DC6FB19E2C96E2AA" modified="2011-04-05" version="1">MSLHRIFLKAAVLSATAACLTLPVLAQTTAPMTPPSATLPLWKSGTPGALGTADDDIPTLAVYLPYANPTHTAVIVAPGGGYQHLSMQKEGSDVAHWLNAHGVAAFVLKYRLGPKYHHPIELGDAQRALRLVRSGAQSYGIDPTRVGMWGFSAGGSLAATTGTLFAPANPASPDPIDRLSDRPDFLILAYPVITMEDPYVHTGSRKYLLGDNPDPALVALLSAEKHVTADTPPTFLFTTTDDHTVPVMNSVLFYSALVAAKVPAELHIFQSGPHGTGLAPGFPDLKVWPDLLATWMRARGYMAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L1</accession>
    <name>E8X3L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1139</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1139"/>
    <dbReference type="EnsemblBacteria" id="ADW68202">
        <property type="protein sequence ID" value="ADW68202"/>
        <property type="gene ID" value="AciX9_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1139"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721140_0_0_0"/>
    <dbReference type="OMA" id="TANPITF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230200" evidence="1">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="383" mass="37898" checksum="E7FB2AF57DA9A24E" modified="2011-04-05" version="1">MSKRVLARVMAAAGVSAVALLSGCSGFFVPETTTTTGSTGTSSGDYVYIVNQTSDTLSGLVVGTSTLTGATGSPYGLTQGLTPSSVAVTRANTFVYVGGAGAIEFFSIGTGGALTLQNSAAASAAANFVSMDTSPDGQWLLALDSITDSLYVFGINSTTGALTLTAQASYSLAANANAAVPKMVRLSPNGAYVFLALGAAGDVILPFVTSNGSLGTTEQALALPSGFSDNAVAIDANSAFVYFARGGTNAGTSGVASYSLGTGGLLTAVQTLAVSGDAPYSILLDATGTYAYTANRGDGTVSGFSIASGTLKALTGSPYKSGTLATALVEDNSKKYVIAGAFGASPDLTMYSFDTTTAGQLDSAGTFASGTDPAGVFALAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L3</accession>
    <name>E8X3L3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1141</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579527.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1141"/>
    <dbReference type="EnsemblBacteria" id="ADW68204">
        <property type="protein sequence ID" value="ADW68204"/>
        <property type="gene ID" value="AciX9_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1141"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_1_0_0"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="11609" checksum="5D78F4ED52DA0E68" modified="2011-04-05" version="1">MIETWRESWLREFFVNDVYSKKIPADLRDRLFRKLQLLDDASTDADLRVPPSNRFEHLSGKLEGFCSIRVNDKWRLIFQWSEGKATELCLDDHSYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N9</accession>
    <name>E8X3N9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">AciX9_1167</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579553.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1167"/>
    <dbReference type="EnsemblBacteria" id="ADW68230">
        <property type="protein sequence ID" value="ADW68230"/>
        <property type="gene ID" value="AciX9_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1167"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_0"/>
    <dbReference type="OMA" id="VIWPCIL"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="745"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="664"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADW68230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="848" mass="92039" checksum="AE7ED46A3EAB0D38" modified="2011-04-05" version="1">MPDPSCSFYVTTPIYYVNARPHIGHAYTTIVADVLARRARAQGTPTWFLTGTDEHGQKIERSALAAGIPPQTFTDQVSASFRDLWKRMGITNDQYIRTTDEAHKKGVQKLFADLHAKGQIYLSTYTGQYSIGEEMFVEGPPGTIGPDGKPTETVTEENFFFRLSDYQLPLLNLIESDTLKITPEARKNEVLSFLRGNTSGAPGPDSGTWVSTDLKQSAKGILYLPGALKDLSVSRSSFTWGIPVPEPAASEAKEKHVIYVWLDALANYITALGYGSDDTTQFEKFWPADIHLVGKEIIRFHCVYWPAFLLAAGLDLPKAVTAHGWLLFDDSKMSKSKGNIVRTETILDAFGTLLPPPAALTSDALALGIRGGLQPPVNGTENEGALAPGSPTPPPEPTKQDQDLFAADVLRYFLLREIPFGQDGSFTFEALITRYNADLANGYGNLVSRTLNMIHKYFDGVVPPSWVSSNSVVLESSVKESQLFDRFVNDNSSGTWVTRLPSEAVALSLAVGRNTQLLRFNKALEACSELIRLLDSDLTSKAPWKVIVGLSDDEMQEKRASVLYTAAESIRIITALLHPILPYATAKVWHQLGLGDIELAAANGELKNLTWGGLQPGTKLGPLSPIFPRADKGLAQTMSDMEQEKSKAPVSNAPVSKLVDEKFNASPETPQDPTHPGAPPRAFGEATTVAGSNAHSTERPGTPPHAEAASGIFSAPFMPESNPGMSGSTPAAGPADASPQITIDDFAKIELRVAQILVCERIPKADKLLRLEVDLGYEKRQILSGIAEWYTPEDLIGRRIVVITNLAPRKMRGLESHGMLLAASTEGGKPHLATFAGADDLPLGSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z3</accession>
    <name>E8X3Z3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3496</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581812.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3496"/>
    <dbReference type="EnsemblBacteria" id="ADW70501">
        <property type="protein sequence ID" value="ADW70501"/>
        <property type="gene ID" value="AciX9_3496"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3496"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899451_0_0_0"/>
    <dbReference type="OMA" id="IMGHRAM"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="32638" checksum="E41F1BEC5A9C35A6" modified="2011-04-05" version="1">MAKTIGVVLSERVLAGLVVDHKLDGPVRAFPEAADDESGLVEMHTESLIKTICEQVILVQNGHKDIAAVGVAMPGLMKAGVVEDSPNLPQLKGAHISELLSAELKNHGLDVPVHILNDADGVAAGLAAAQGKLDHFIRVWTLGVGIGYGRYPFAPGVWEGGHAVVTLDDKENYCGCGGRGHLEGIMGHRAMRLRFLDMEPEEVFAEAKKGPKGGPGGDDRCFQFKKLWHKALAAGTASSIHNEGPGKFFLTGFNSRFIDLPMLKDYIQQMVKMSPLQSYTLEIVNDDADIRVVGAAVAAELSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X407</accession>
    <name>E8X407_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581826.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3510"/>
    <dbReference type="EnsemblBacteria" id="ADW70515">
        <property type="protein sequence ID" value="ADW70515"/>
        <property type="gene ID" value="AciX9_3510"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3510"/>
    <dbReference type="eggNOG" id="ENOG5032R7J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370511_0_0_0"/>
    <dbReference type="OMA" id="CKISERG"/>
    <dbReference type="OrthoDB" id="1789861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230209" evidence="1">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22137" checksum="A061E0BE008EA7A2" modified="2011-04-05" version="1">MTINQVRMAVLVGAAGALLASVTGCRVEDHKDGDATNVKIATPFGGMSVKTNDKVIQGNMGLDVYPGAVLERKKNENDSAADINMSFGSFHLGVKAVSYTTPDSTDQVMAFYQKDLSKHGSVIKCKDDRPVGMPVRTDDGLTCDDDDKKNTVQVNAKDGKGTVELKFGSKQHQHIVSIEPHDGGTKIGLVALDLPGNFSVTDEDNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X444</accession>
    <name>E8X444_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ordered locus">AciX9_0013</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0013"/>
    <dbReference type="EnsemblBacteria" id="ADW67104">
        <property type="protein sequence ID" value="ADW67104"/>
        <property type="gene ID" value="AciX9_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0013"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_0"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="772"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="565"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="848" mass="92555" checksum="9F80F55EB0D8D037" modified="2011-04-05" version="1">MTQLLPQIPSPLLESSSLALEWPRLRALIAAKAISPLGRAWTLALEPSTDLTWIIAQQTRTSELRSFLTGGGSFDFHGLFDPEALLAKARIDGTALESLEILTLLNLTERVAAWRSLLAAAESARRLGPSIRALSEPLSYHDLAPLLRTLRGKIEPDGSLSDDASPELKRIRRAMESQHRAIEASLRRAARALREEGSTQSDRDDLITVRGERFVIPIKAEFKRKVPGVIHGSSSSGQTVYVEPLETIEQNNELVRLLDEEQSEIHRILVALTRALAAQAHVLSIGTIILAEVESHFIRARFAQDLDCTAPTFTPGLSLKSARHPLLELRMRAENLGAPGPDSRTWVGTTDTPERKPTKPIPLTLALTTEARQLIISGPNTGGKTVSLKTTGLLALMAQAGLLVPAEEATFPLFTAIFADIGDAQSIERNLSSFSAHVVNVDHISRHADGHSLVLLDELGSATDPEEGAALAVAVAEHFLNLNAWTAITTHLTSLKVYAAQHTGVLNAAVGFDQATLTPTYELRLGVPGASAGLNIAARLGMAPTIIASARAQMTTQQADIGAFLDQLHDQISAATSERVSLKRRTEEVATERARLETEGRAEQKQRTRELELKLKTLLEDFETQLKETVNEIEDKTVARKIQRDSALRMARVRREFSDQFSSTVLAHTAGADKNDIASPLARRALTPIKAGDYVTLKSLRRQATVVRVIDEHNFEVSMGQMKMRVPRTDIADVEVIKVVTPAEAARRRGNITVQTASGAPLGDSDYTPREINVIGRTAAEAEDEVSRYIDKAFLSGLERVRIVHGTGMGVLRRTLREFLKSHPHVATFAEASQQEGGQGATLVDLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A9</accession>
    <name>E8X4A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579559.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1173"/>
    <dbReference type="EnsemblBacteria" id="ADW68236">
        <property type="protein sequence ID" value="ADW68236"/>
        <property type="gene ID" value="AciX9_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1173"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_2_0"/>
    <dbReference type="OMA" id="CELEWIA"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="17559" checksum="E080FB569BB02321" modified="2011-04-05" version="1">MIRVGTEGDLEAIVRLEREITTAPHWGIGEYEGIVRGDGVRRCLYVADAGGVVGFAVGKVVVDEGEVESIAVRETSRGCGVGGRLLTEVLEWCREAGAGVVDLEVRAGSEGAGRLYRAAGFVEIGRRRGYYSGPVEDAVLMRVTFDRTPEGLDRGGGADFERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H7</accession>
    <name>E8X4H7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1241</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1241"/>
    <dbReference type="ESTHER" id="acism-e8x4h7">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68304">
        <property type="protein sequence ID" value="ADW68304"/>
        <property type="gene ID" value="AciX9_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1241"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_0"/>
    <dbReference type="OMA" id="GHKVQQY"/>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="546" mass="58980" checksum="7DDD198946377CE5" modified="2011-04-05" version="1">MSASVMVGRRAVLRYSGLVGMAAVMGPVGALGEGVRVAKTSGGRVSGALVDGVKVFKGIAYGADTRGTRFMAPKKVAAWAGVKACTEWPHRAPQQQGAERGQRAVEDGHYHLPADQGVQSEDCLYLNVWTRGLRDGKKRPVVFYIHGGAYNNGTVNADLYDGRRLCQRGDVVVVTVNHRLNAFGYMELASLPGLAERYKDSGNVGMLDLVLALEWVRDNIAEFGGDAGRVTIFGQSGGGAKCATLMAMESAKGLFHRVLTMSGQQVWAAPMALATERAKVALKAMGLDPAKPGQVTAEALDGLTMEQIQAGARTTGSWLPVKDGWVLARDPFDPDAPGMSAKIPMILGNTKDEIMGGTAWRQAGLTWETLPAELGKAIAEFRGPYPVEEIVAAYRRWYPGYKPVDVFVAAMAAFRSWPGQVIEAERRASDPVSAKRTWVYQMDFPSPTADGRAPHTEDLAFVFDNLRLSPGMVGASEAEIATAQPLATRMSGMLIEFARTGAVDWPVYGLKDRETMMFDRVSKVGSDPRGDERRMMVGAKYRQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R6</accession>
    <name>E8X4R6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3551</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581866.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3551"/>
    <dbReference type="EnsemblBacteria" id="ADW70555">
        <property type="protein sequence ID" value="ADW70555"/>
        <property type="gene ID" value="AciX9_3551"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3551"/>
    <dbReference type="eggNOG" id="ENOG50348CD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179211_0_0_0"/>
    <dbReference type="OMA" id="KRENQDP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230689" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="10099" checksum="F761E385CEE4AD57" modified="2011-04-05" version="1">MNVSKLSSLVVLSAMVAAPLSGLAQHSAAYYRAKRSQSRHDSRHHTPAKVIGGSAAGGAVIGALAGGGKGALIGGAIGAGGGVVANKVRTDKGIKAREREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S7</accession>
    <name>E8X4S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3562</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581877.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3562"/>
    <dbReference type="EnsemblBacteria" id="ADW70566">
        <property type="protein sequence ID" value="ADW70566"/>
        <property type="gene ID" value="AciX9_3562"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3562"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046417_1_0_0"/>
    <dbReference type="OMA" id="EQDFVMF"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="39647" checksum="9CA7318CA0BA6409" modified="2011-04-05" version="1">MSGFVRYSDSVEVLQPGEEQTFDEITATLLDISKKVGERQRHTVRSVHAKSHALLKAEVTVLDGLPEQLRQGLFAKPGSYGAIMRFSTNPGDILSDHISTPRGLAIKIVGVEGEMVPSHAGEVTQDLVMVNGKAFAAPNAAGFLKGLKTLDAHANDSEALKQTVSSVAQVAESALETVGGKSPTLLGFGHPPTNPLGETFSTVVPLRYGDYFGKIELVPVSKNLVDLCGKHLENAREWNALKDSNVKFFAHETSIWELRVQLCTDLDKMPVEKADVPWDETLSPYVTVAQVTVKAQEAYSDARRVYVDEELSFNPWHCLAAHRPLGNVMRARFKAYKASTKFRHAAEGRVMVEPKSIEELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y4</accession>
    <name>E8X4Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0086</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578505.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0086"/>
    <dbReference type="REBASE" id="32573">
        <property type="entry name" value="AspMP5ORF87P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67176">
        <property type="protein sequence ID" value="ADW67176"/>
        <property type="gene ID" value="AciX9_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0086"/>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008785_0_0_0"/>
    <dbReference type="OMA" id="FCQVEAV"/>
    <dbReference type="OrthoDB" id="13585at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="1">
        <location>
            <begin position="130"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117003" checksum="7673E2954147A398" modified="2011-04-05" version="1">MSTEQSFFERPILNSPYLPSHRHWELDSEGQPTHLIVPTRRRAEFISPIPKPRLRRGQGRQAALVLQDEAGLSTDTQQYASTIINDLRGEVDAWRRLPSRSDWKVSAETARLLAHWRSDSFTSVRPFFCQVEAVETVIWLMEVAPLRESWRKKYLNHLSESNADANPGLARLALKLATGAGKTTVMAMLIAWQTINAVRRPKSQFTKGFLIVAPGLTIRDRLNVLKPNDTYNYYEHRDLVPKDMLQDMQRAVVVIENYHKFKIRERTSLAKGTRRMLEGRDGEVQTLETEGQMLQRVVGDLMGMKNILVINDEAHHCYREKSGETAEREIGADEREEAKANAEAARVWITGLEMVKRHIGISRILDLSATPFFLRGSGYREGTLFPWTMSDFSLMDAIECGIVKLPRVPVTDNITSADVPIFRNLWENISKDMPKKGAGKAGLLEPERLPLKLKAALDALYSHYKKTFELWQQNGIEVPPCFIVVCNNTSASKLVSDYISGYARETPEGSVPIPGHLPLFRNEDENGRPYSRPRTILVDSHQMEAGGDLDENFRKAAAAEIERFRQELRARGEHDKAANLTDSDLLREVMNTVGRKGALGESVRCVVSVSMLTEGWDTQTVTHVLGVRAFGTQLLCEQVIGRALRRQSYELITEGAEAGHLPVEYADVLGIPFDFTAKSVPAPPQAPRKVISVKALKERAGLEINFPRVQGYRVVMPRERLAAEFNEDSAYVLTPNEVGPTDTRIEGIVGEGINIGPDHLREARYSTIVFELVSHMLKTSWKDAQIERPGPHLFMDLKRIAREWLDNYLQCVGGTQPAQMLDPRLLERASQRITTGITRRMSGETGIAAILDPYNPLGSTAQVNFNTTKTDLWKTAPDRCHVNWVVLDSMWEGEFCRVAEQHARVRCYVKNHALGFEVPYQRGAENHIYRPDFIVRVEDGHGEDDLLSLVVEIKGYRGEDAKDKRSTMETLWLPGINRTGSHGRWAFAEFTSAYAIEEEFKARVESLFHEMIADASLYGRQHQPSARDKKEDTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X537</accession>
    <name>E8X537_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0155</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0155"/>
    <dbReference type="EnsemblBacteria" id="ADW67229">
        <property type="protein sequence ID" value="ADW67229"/>
        <property type="gene ID" value="AciX9_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0155"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_5_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="565" mass="62655" checksum="36E7BBBC546399A2" modified="2011-04-05" version="1">MEESAKSFRLRNSWIPVDESAFEQEVIHTPGLVQPFGVLLACRRSDLRIVHVSANCDWILGREPREVLQMTLPALFGQEQSDEVTRALSEPGHRSASRLSIGKLRPGGLENHVVAHTIDADLICIELEPSLPGHRWDLLSKRLESIVEALQKTGSQQDLCDAAAKEMRALTGHDHVMIYKFHPDHHGEVIAEDKIAELSPNINLHFPASDIPQQARALYLLQRTRLIADVDYVPVPLVSLKHASVPCALDMTYSSLRSVSPMHLQYLRNMKVGASFSISLVHEQKLWGLIICQHRTPLLVPPEVRSLCDLLGQVISMLTGVTQNNEDYVEQLFNGSRLKELESVLAGPCVISEMLVEHADLFLGSVGASGATICIDGQLRSCGTVLPPHERHALLALLKEHGDEPIFLSEYLAGIMPALKIYKDVASGILAIPLDGSYKSYVLWYRPEITQTVEWGGNPNEAKVRDVVTGLVGPRESFAAWRESVSGHAKAWSPRERAMALDVQRLLKATVSRQGDAAKAKLSLVDVLTLLPNRRVLLDRLSRLQEDGVLEHASLLFVTWTDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X561</accession>
    <name>E8X561_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">AciX9_1263</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579648.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1263"/>
    <dbReference type="EnsemblBacteria" id="ADW68325">
        <property type="protein sequence ID" value="ADW68325"/>
        <property type="gene ID" value="AciX9_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1263"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_1_0"/>
    <dbReference type="OMA" id="YVNCKPV"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="23050" checksum="D44C05DDE24F6F4A" modified="2011-04-05" version="1">MPANPRAALLDLIATLSFKLGDFTLASGAKSDYYIDCRITTLHAEGGRLSGIVLYELIRQHLPTAVAVGGLTMGADPLVSNTATASAAALADYEEIQLLTSELDLDAPAEEEPAPTLIHGFLVRKAEKTHGTGRLLEGFLQPGAEVVIVDDVCTTGGSTIQAIEATRAAGMKVIGVLCLVDREQGGRAKIEAALKTNEGDVPFIPVFTATDVRRAHKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X569</accession>
    <name>E8X569_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579656.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1271"/>
    <dbReference type="EnsemblBacteria" id="ADW68333">
        <property type="protein sequence ID" value="ADW68333"/>
        <property type="gene ID" value="AciX9_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1271"/>
    <dbReference type="eggNOG" id="ENOG5032SQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179277_0_1_0"/>
    <dbReference type="OMA" id="VIECKHV"/>
    <dbReference type="OrthoDB" id="2036019at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10134" checksum="A924472A3DD3439F" modified="2011-04-05" version="1">MVLECKHVWTHISAYLDGTLDPTLLAEVQRHLEHCEICSAILDSTRNILVLTADERVFELPLGFSDRLHARLAQEMKLAAQDEPVRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X597</accession>
    <name>E8X597_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall hydrolase/autolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1299</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579684.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1299"/>
    <dbReference type="EnsemblBacteria" id="ADW68361">
        <property type="protein sequence ID" value="ADW68361"/>
        <property type="gene ID" value="AciX9_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1299"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071603_0_0_0"/>
    <dbReference type="OMA" id="HPIASQK"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230239" evidence="2">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="50"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="35068" checksum="6EFA96F78C8D52CC" modified="2011-04-05" version="1">MIPFRIAVLLLAASSVQASAQTDAPAATPTPKPHKRAAKPYQPSFNPTLILLDPAHGNQDSGATLGPNLKEKDLNLAFAQRLRGLLQAKGFTVQLTREADAPAPAAAPPADPDNPTPPPPPPPQLTPDQRAEQANRLHPGACLLIHTTPAGHGVHLFLSALTAPNTQAEPRQVLLWDTAQAPALAHSTTLSGRLAETLTAQSIPLVTGRVSVKPIDSMSCPAVTLEIAPLAEKGGKTTPVQDQAYQQKVAAAIAEGLGNWRTDAEAILQAEAAEAARAAAALNPAKPEPAKPAAKPKPAKPVVTPGHLIPGQIAPLPKIPQIVAPTTKRPAAPAPGVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D0</accession>
    <name>E8X5D0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2442</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580793.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2442"/>
    <dbReference type="EnsemblBacteria" id="ADW69477">
        <property type="protein sequence ID" value="ADW69477"/>
        <property type="gene ID" value="AciX9_2442"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2442"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_5_0"/>
    <dbReference type="OMA" id="NILNMTR"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="278"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="53696" checksum="54C60A7D1B3E3B8E" modified="2011-04-05" version="1">MNLSFAKFEHAIARRITNPPHVEIARATIAVIITICLSASAFALHLNLASAISILLLATVVASIQWGVIQGTAVSLAAVGCLDFLFTAPLFKFSVHNRENWIALMTFEITALMVSRLSWKERLHAREQEYQRQGISKLYQLSNAILLVDTRSSWLEQLSALLREFFSVESVELWIAPDDRAFSATAEVNAVENAAYRVFAAGDDTDSVEGGWSHRVLRMGTSSIGGMVLQGWEVDPAIADAAGSLIAVAVERARSAQKESHAEAARNTEQLRTAVLDALAHGFKTPLTAIQTASSGLLAIGRLSEIQSELVEIIDQEVGMLAGLTSRLLRTAALDAREIKVRSSQVSLLPLVEGIVMEHDEETRRRIHIASPPVLMDIQADPQLLTLALAQVVDNASKYSTVGSRIDLRFIQDESRTIITVSNQSEPLRKEDLGRIFERYYRGAQAGKGPTGTGLGLSIVKKIAEAHGGDATATCQGNEISISLRLPGGTRLSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L7</accession>
    <name>E8X5L7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3641</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581955.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3641"/>
    <dbReference type="EnsemblBacteria" id="ADW70644">
        <property type="protein sequence ID" value="ADW70644"/>
        <property type="gene ID" value="AciX9_3641"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3641"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_0_0"/>
    <dbReference type="OMA" id="QFWMNLQ"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12300" checksum="42A3A4BFB41D0316" modified="2011-04-05" version="1">MNIIERPTTGWRIQGITTHPGAVLREDFMAPIALTANQLALRTRMPATRIGEILHERRSVSPDTALRLARCFGTSPEFWLNLQAAHDLSKARLASETIIEKEVEPLKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U3</accession>
    <name>E8X5U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4031</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70827">
        <property type="protein sequence ID" value="ADW70827"/>
        <property type="gene ID" value="AciX9_4031"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4031"/>
    <dbReference type="HOGENOM" id="CLU_1249242_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="22857" checksum="68C43B24D2AE71E8" modified="2011-04-05" version="1">MSNVNGKVYAMNVITPMRPWKTFALRAIFFALWHIKPLQSDLINLSFIEFARWVIIPRRRFPHLGHGQEKEDLKYDYLLFFSNFNGTWNQYIDAFSAVLSKGLNLIWRWSDKFPGSVPVTPFKEYIARVQFDTDYYYTAYPHATANDLKSAHVVQEAFDALSTQAQGSTPEQFAEAYRDFVLQVQCHLGETGEAPVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X650</accession>
    <name>E8X650_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4154</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70934">
        <property type="protein sequence ID" value="ADW70934"/>
        <property type="gene ID" value="AciX9_4154"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4154"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="YGQDDAH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="29069" checksum="1228A8F9B0E3FD52" modified="2011-04-05" version="1">MQAAMVEHSGLLAQFLPMMNQDFNFAPRATEETASAAYRVLIMESSASLAKLLATGLTAESLAVDVTHDVASAARLLESRAYNLMIMDMDPPDADGVNLLQTIRTTRPDLRVLVLSGRSGVEGLVAALDHGADDYLMKPFSLIELMARIRALRRRSDAPAQQAAAPKSSKIVLNHDQCRVQRDGKNIDLTPREFALLQYMMDNAGKTLSRAMLTQEVWNMPAEANTNIVDVYVKYLRDKLDGDHDEKLIRTVRGMGYLFQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B2</accession>
    <name>E8X6B2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASPIC/UnbV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4218</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572908.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70996">
        <property type="protein sequence ID" value="ADW70996"/>
        <property type="gene ID" value="AciX9_4218"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4218"/>
    <dbReference type="HOGENOM" id="CLU_017657_0_0_0"/>
    <dbReference type="OMA" id="MDLLVYY"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="486"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="563" mass="60123" checksum="671FD0522BD95468" modified="2011-04-05" version="1">MLLLFLLLAVGVQAQQVYPASAEHPTPAWFVDVAAKAGITVRNVNGSEEHKKYIVEATGSGVAIIDYDRDGWPDIFLVNGTDLGSAGKTAASNHLLHNNHDGTFTDVTAKAGMVSTGWGQGACVGDYDNDGFDDIYVTGYGKGRLFHNLGNGSFKEVAEAAGVAGSGKEWGTGCAFVDYDRDGKLDLVIANYVHFDLAKTPAPGADAGCMWKGSPVMCGPRGLPSAPNILFHNDGGGKFTDVSKAAGIEKTAGHYCFSVTTLDYNEDGWPDIYMACDSTPSILYRNNHDGTFTDVAADVGVAFNEDGREQAGMGATAADYDGDGHLDLFKTNFSDDTATLYKSHGDGTYTDETFAAGLGINSDALGWGAMFADVDNDGYPDLIVVNGHVYPEVDSAKLGAAYREPRFLYWNQGNGKFKDVSKGAGPGMTEPMAGRGLAIADLWNDGRLEAIVNNLSDRPMLLVNEAKNTNHWLGIKLTGTKSNRDGIGGRVVVRGTKRSWVDEVRSGSSYNSSNDLRLHFGLGAEMHVADVTVRWPNGESEVFTVAGVDRMVEFVEGKGKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F0</accession>
    <name>E8X6F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4258</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71034">
        <property type="protein sequence ID" value="ADW71034"/>
        <property type="gene ID" value="AciX9_4258"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4258"/>
    <dbReference type="HOGENOM" id="CLU_035441_0_0_0"/>
    <dbReference type="OMA" id="HEMIPGH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="558" mass="64191" checksum="5AF8BF9EE90FC6F2" modified="2011-04-05" version="1">MPTVIEQFSADRMSLMRTYSVNVAPARFERFEKFYHDELAMLAGINFEGLCEDDRVDYLLMKNRLTADLHQLEIQKTQTAEMQPLLPFAKTIVELTEQKRLMKQPDGEKAAAMLSVMVKEMKAAQKALDPTSGHRGASAAEGTEKPKISPVVANRAVQATRQLSAALKDWYGQYDGYDPTFTWWVAEPYKDADKALTSYTAFLKEKLVGVSADDKTTIIGDPVGREALLNELSDDMIPYTPEELIAIAQTEYDWCMKEMLKNSHEMGFGDDWHAAVEKVKQMHVPPGEQPELIRKLVVEGSDFVKKNDLVTVPPLADETWRMVMMTPERQLVNPFFTGGNEISVSYPTDTMTYEQREMSMRGNNIPFAHATAFHEMIPGHFLQFYMSARYHTYRRPFSTPFWHEGNSLWWEMLFYEMNFNKTPEDRVGALVWRMHRSARVIFTMNFHLGKWTPQQCVQFLIDNVGFESENALAEVRRSFDGSVGPLYQCAYLMGGLQFRAMHKELVDSKKMTNREFHDAILHEGPMPIEMLRADIERQKLSSDFTTSWKFYGDHPTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F8</accession>
    <name>E8X6F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4269</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71042">
        <property type="protein sequence ID" value="ADW71042"/>
        <property type="gene ID" value="AciX9_4269"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4269"/>
    <dbReference type="HOGENOM" id="CLU_068254_0_0_0"/>
    <dbReference type="OMA" id="WSHGGMI"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233740" evidence="1">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="134"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="37834" checksum="78E04B7AB60477FB" modified="2011-04-05" version="1">MLLRRTILTILVLSATIAAAQARKPTAPAEDSQSGAAEKYHLDEIAKATDDVAWHQQMDSLATVEKIVYTGLPDVHAKDKDFGPQPMILYAYTFIPKGWEGKKKHPLVVFLHGGVHGSTLTGGPDNDGRLISELVQQGYAVISPEYRGSGGYGQPYERAMDYGARENDDALQARDWMLQRYSFLDPARVGLVGWSHGGMIALMNLLQHPEGYACAFAGVPVSDLAERMTYVTKKYRQEMAENIGKDVDEDKDAYLRRSPVFYAGQLSRPLLIDANTTDETVHIVEVRHLLSAFDAAHKQYKSHIYEQAPGGHFFNRIDTSLAVTSRQEVYAFLREYLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H1</accession>
    <name>E8X6H1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4286</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71055">
        <property type="protein sequence ID" value="ADW71055"/>
        <property type="gene ID" value="AciX9_4286"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4286"/>
    <dbReference type="HOGENOM" id="CLU_393765_0_0_0"/>
    <dbReference type="OMA" id="FGHLHHV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230797" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="46"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="239"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="717" mass="79847" checksum="3B333367DC99E500" modified="2011-04-05" version="1">MKIYKSVKRCSAPRLSGFMRCMVVYCLLRAAVGHTQTLDPKAPTFSPIPREVHAGQRVVVRSATVVVPGGDAEDLFAAHDLEKLFKASGISISPGIGAPTLMVQLLRKDSPQAAGLLKQSGLAFGPEMSAEGYVIVAHTPVVAVIGETSAGVFYGVQTVKQMVESEGGVARIWTGTVSDWPAMRYRGIHDDLSRGPFPTLEFQKHQLEVFAAHKVNLYSPYFEHTLQYAGDPLAAPPGSSLTRAESQDLEEFASRRHIMIVPEQEAFGHLHHVLQYEKYADLAETPHGHVIAPGQAGAQPLIKSWFTQIAEDFPSPFLHIGADETFELGTGRTKSEVDKKGLGPVYAQFLNTIHTTLAPLNRRLLFWGDLVWSDPASVSLLPKDMIAIPWIYWHEDSYDHNLLPFKKAGIETWVAPGDANWRVVYPLGKTALDNISGFVEAGQRLGSTGELTVVWNDDGEGLFNQDWFGVLFGAAAGWQPAKIDGAAYQARFGRVFYGDMTGRIDQAQKELMDAESLVDVADDVFWMDPWSKAGQAKATKMRANIPAARLHAEKAIELIEEARTTDATLREQDALKAMELGARRIDFIGMKFQLADEMKAAYAQAYQQKDDKKRETETRELLYSISSMNGRCQDLRDGYSMIKNLYRDSWLAENRPYWIDNVLVRYDLQIQLWERRGEDINALIDEWQSTKTLPRAEEAGIPPLLESALAKPVDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N6</accession>
    <name>E8X6N6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3910</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582204.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71186">
        <property type="protein sequence ID" value="ADW71186"/>
        <property type="gene ID" value="AciX9_3910"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3910"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="SARMGEM"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="249"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="468" mass="51134" checksum="C8BF8328799768A9" modified="2011-04-05" version="1">MKAYSLTRRLITAILLVELCSTLILVTSAGIYEGISRFRAFDIMLRGRADSMLGAVQDAEDPQDNVMLDGTQSFAPQRDIYAVRDELGRLLGHSHNWPDAESAFNSSHSGFSSLKIAGRSYRVIRVEGLRMVDPGDKGGGIPRHVVILYGARTHPLWESIEHTIAFYALLSLILLATSGLIMLRLLRRGLSPLTDLAAHAAQVSVDSWHFHPSDTVRAVQELAPLANALETVLARLERSFEQQRHFVSDAAHELKTSVAVIKSTLQLLVMKNRTAEEYREGLKRAEADSERMEQLVAAMLTLAGLEATNTLSTSRSHADLTEILAEVTQHFQSISEASGITITLHAPTHVTVIGDREKIRLLCSNLIHNALQHSPPGAEIRAIVTSAPQATQLRIEDDGEGIASEALPHVFERFYRGDVSRSRKTGGTGLGLAISKAIVQELHGAIAIESTIAQGTRVIVDLPHSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W4</accession>
    <name>E8X6W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="8"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582282.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71264">
        <property type="protein sequence ID" value="ADW71264"/>
        <property type="gene ID" value="AciX9_3990"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3990"/>
    <dbReference type="HOGENOM" id="CLU_014379_3_1_0"/>
    <dbReference type="OMA" id="FGGIAWH"/>
    <dbReference type="OrthoDB" id="447059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230295" evidence="5">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30" evidence="6">
        <location>
            <begin position="72"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30C" evidence="7">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="471" mass="51122" checksum="B671DE0F5FC4C5C1" modified="2011-04-05" version="1">MIRHSLFACTALVLFSSSVAHAQTKPDVDVWLTNSDRTALLARQSPELKFVAGAGSGTVIQVDDTKRFQQMDGFGYALTGGSAELLMKMQPAKRTELLQELFGVKGSAIGVSYLRVSIGASDMNERVFTYDDLPAGETDPMLAKFGLGPDLQDVVPVLKEILAIDPKIAILASPWTAPSWMKTNELPKGGSLKPEDYEVYAQYFVKYLHAMAAEGITIKAITMQNEPRNPKNTPSMVMTADEQKTFLADALGPALHKAGLKTDVILYDHNCDDPEYPLTALADPKASQYAKGSGFHLYEGTIDAMSKVHDAYPSKDLYFTEQMVIQKDATKPLRVADTVSHLIVGAPRNWSRNVLLWNLAADPDNGPHTPNGGCPICQGAITLDGDQVTRNLAFYTLAHASKFVRPGSVRVESGSSVAGVLPNVAFSTPDKGMVLIVANPGKEQQAFSVEFHHKSFSATLNAGDVATYVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X776</accession>
    <name>E8X776_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">AciX9_4358</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573029.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71310">
        <property type="protein sequence ID" value="ADW71310"/>
        <property type="gene ID" value="AciX9_4358"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4358"/>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_0"/>
    <dbReference type="OMA" id="SMKVQQR"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10325" checksum="C45E6FCBC6A98609" modified="2011-04-05" version="1">MSYPASTQQDADTTSLFRNLILEIAQSLVDDSEQVKVDIIKGELATVLRLTVASTDLGKVIGKQGRTARSIRTVLGAASMKVQQRFELDIASQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X794</accession>
    <name>E8X794_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4376</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71328">
        <property type="protein sequence ID" value="ADW71328"/>
        <property type="gene ID" value="AciX9_4376"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4376"/>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_0"/>
    <dbReference type="OMA" id="AMEREMH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="36360" checksum="20D325E7EC0FB766" modified="2011-04-05" version="1">MAMKQQTFASQSSFEKYGRKSRRELFLDEMEVVVPWPELQALVEPHYPKAGNGRRPVGLAIMLRTYFMQQWFNLSDPGVEEAFYESFTLRRFAGVDLGVAPAPDETTVLRFRHLLEKHDLGGAMLDAVNLHLAARGIRIETGTIVDATIIHAPSSTKNEKKERDPAMRQTRKGKQWYFGLKAHIGVDAKEGHVHSVATSAANVSDVHMLPDLLHGDERKVWGDGGYQGQTKAIRQAAPKAQDMTCKRTRFKNYVDEAAKKKNTTKSKVRAKVEHVFRVLKRVFGFDKVRYRGIAKNHHRLCANFALINLYLHRKHLAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A7</accession>
    <name>E8X7A7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573060.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71341">
        <property type="protein sequence ID" value="ADW71341"/>
        <property type="gene ID" value="AciX9_4390"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4390"/>
    <dbReference type="HOGENOM" id="CLU_102561_2_1_0"/>
    <dbReference type="OMA" id="AKTCEAM"/>
    <dbReference type="OrthoDB" id="1739824at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="197" mass="21140" checksum="1A9FB5BEF2AAC06E" modified="2011-04-05" version="1">MALKTVLIDELRDMYSAENQLVKALPKLAKGSKNPKLKSIFTAHLAETKGQVERLKKVFAELGEKPTGQHCNGMEGVIEEGKDALEKDEEGSSFEAGLIGAALRTEHYEIAGYETCISMATALGLPKIVKLLNSNLKEELAAAKKITAAGAPIMKLSAKEPESPKEPKSGKEKYSAKKSKEDEAKAAPDLAAESAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I3</accession>
    <name>E8X7I3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Barstar (Barnase inhibitor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4471</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573136.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71417">
        <property type="protein sequence ID" value="ADW71417"/>
        <property type="gene ID" value="AciX9_4471"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4471"/>
    <dbReference type="HOGENOM" id="CLU_147895_0_0_0"/>
    <dbReference type="OMA" id="GRNMDAW"/>
    <dbReference type="OrthoDB" id="2047621at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12202" checksum="5BC664C5624E0856" modified="2011-04-05" version="1">MTAKVSLDCNSIKDWDSFHDEFATVFGFPAFYGRNMDAWVDCLPSLDASEDGMSTVHCEPGSVVTLSLSNVKAFAERCPQQYSAVIECSAFVNWRRLQAGDPSVLALSFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M1</accession>
    <name>E8X7M1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4514</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4514"/>
    <dbReference type="EnsemblBacteria" id="ADW71455">
        <property type="protein sequence ID" value="ADW71455"/>
        <property type="gene ID" value="AciX9_4514"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4514"/>
    <dbReference type="HOGENOM" id="CLU_2478981_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9792" checksum="1AE12084BC8180FC" modified="2011-04-05" version="1">MNSLRDILAAPELKDVRAAVGEQEPLHETYALASSPQRQTPAWSVAECTICQRFFRRGEYLRCSQCKAAVCKTGTCKSVHRVTEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P1</accession>
    <name>E8X7P1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4538</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4538"/>
    <dbReference type="EnsemblBacteria" id="ADW71475">
        <property type="protein sequence ID" value="ADW71475"/>
        <property type="gene ID" value="AciX9_4538"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4538"/>
    <dbReference type="HOGENOM" id="CLU_3025930_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="55" mass="6270" checksum="4EF674180238F9B4" modified="2011-04-05" version="1">MQEQLESTPEETGIEGNELRNENYDHGFQAALDGEPYDPETQTEAWQKGWADANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X806</accession>
    <name>E8X806_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4660</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71590">
        <property type="protein sequence ID" value="ADW71590"/>
        <property type="gene ID" value="AciX9_4660"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4660"/>
    <dbReference type="HOGENOM" id="CLU_617870_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="48370" checksum="D04ACE04BCC329CC" modified="2011-04-05" version="1">MMMKYKSKRMLLAFGALACLAVAVSCYLGLRYAQTAGAIGDIRIHRLPLRGDPYSVTISPDGSTVATLGFVSGAPADAIEIWDVTSGHEVNKVYLPKVSWDKGGQLRVSPLLQFCDQGKYLAAFDRLNKIYIIDTKDYTVHAAIALAEIPVGLHQGGTPRPLREVSGYNAIELSCSAGSAFAALRVWMNGKNVVKVFDFDAGAETADLTESFDGIQGDGVAISPDGSKVAADVWNMQPAGPYDEYDEVAEVVDRASGKLIQRLDFGDRKGLNRYQLSFSGENALVVGLPLCQKVMCDDSVMPYGRTIRVLEPQSKEQIKTFGAEGAEAYRFSGASADGREVFGYTGVEKFCRDCNGVSGELKITNARFTVWDRESGKILVRSPKLRVQQHKCHWLVLGACEDSESVPDLQLSDNGKSVVALWPNFDRPGQDKLVGEIQVFSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X827</accession>
    <name>E8X827_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71611">
        <property type="protein sequence ID" value="ADW71611"/>
        <property type="gene ID" value="AciX9_4682"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4682"/>
    <dbReference type="HOGENOM" id="CLU_2990347_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="57" mass="6152" checksum="571569628BE0D9B9" modified="2011-04-05" version="1">MFTIAAGIVLGFVGIVALVVVVRFFQTVPVFKGIAEGWRGFKEGMKGIADPPSDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR2</accession>
    <name>E8WVR2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2564</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580906.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2564"/>
    <dbReference type="EnsemblBacteria" id="ADW69591">
        <property type="protein sequence ID" value="ADW69591"/>
        <property type="gene ID" value="AciX9_2564"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2564"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559924_0_0_0"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="66"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="214"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="487" mass="52976" checksum="0231FC5FEB6B5E21" modified="2011-04-05" version="1">MRKTLEAFKMHRTPPPSKSSLNNPATCIKKFAILATVVLSLVTAPHTAAAQTQNTLPDISAIQSRIRAEDSIVGRAIATHDFAILQRYWSPSLVVNGPTNKIVNRDQVVESMHHGGLNYTSLKGMTELFAVTNGVAIDMGHDDVVTADGPMAGKHIVRRSTNIFQRSGDDWVLIARQATYVGFDGAILGGTVTTSFTPPLPAPEDAAVHAQIDANGRAVGHAIATMDFAALEKLWSPAMVVNSPGNNILTRDQVFAAMREDKLKYESGQVYQDAFFVSKDVAIEMGHEDIVMANGPMAGQPLKRRFTNVWQKVGDTWVQIARQATYVGIDGGAVYGHPDPTLDLVSLAAPNVTPTTEVDGSPEDVKAIEALVHSNPSDHVTENVSFTNIFGTVRFGREEFIQRHKEIGQTFFKGTTSKSSITKLRFVRPDVAVVDVSGELSGFQKLYSGLPVGKDGILRNKLLLVLVKENGVWWITEFHNVAVTPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS1</accession>
    <name>E8WVS1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2574</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2574"/>
    <dbReference type="EnsemblBacteria" id="ADW69600">
        <property type="protein sequence ID" value="ADW69600"/>
        <property type="gene ID" value="AciX9_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2574"/>
    <dbReference type="eggNOG" id="ENOG50325N3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078164_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="37684" checksum="81EB0CE2D3299E0E" modified="2011-04-05" version="1">MGLFDWLLHKRPPFQTHSGSVIRKQLSAEEPIKSSVVWTVPKTEFIDIPERNFFGECVRSPDQRYTLAWRDANESGSQGGARSQGKGKYIVLAGKDVIAQGAVARPNDGKIANDGSFILNDWGFGGGLQGVFLAFDCSGKPLVKRQFEANLFNNGLSVDGSTAACQTANAYEGDDGSKLTIFNLRTGVEVASWIPASGWADFYAFPADGVIQLGYSKLGLFSYRWDGTFLDAEEWQEARLSKGDYSTVMMAVDFAIKSDDGQLEEGLAHRLLKSLDRISPQIPETDVQRKATLKKLQGQCWEAIGDLTTALTEYDSALAINPKVGIKRRADQIRKQQQAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS4</accession>
    <name>E8WVS4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Co-chaperone Hsc20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3682</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3682"/>
    <dbReference type="EnsemblBacteria" id="ADW70683">
        <property type="protein sequence ID" value="ADW70683"/>
        <property type="gene ID" value="AciX9_3682"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3682"/>
    <dbReference type="eggNOG" id="COG1076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_0_2_0"/>
    <dbReference type="OMA" id="VFELNMQ"/>
    <dbReference type="OrthoDB" id="1520143at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="PTHR14021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="23516" checksum="C056D724E7B5B56F" modified="2011-04-05" version="1">MMIAADFFTVFSLPRHLHLDTAALEKAFYAQSRKLHPDRFASRPAAEQEAALAESSRLNDAYRTLKDPILRTQYLLTLEGVELEEQSKAATEYARTSGQEKKQLIPPELLEEVFELNMQLAEMKAARQMGEDDPQLRADLSAAKKTFDEKMAETQIELETLWARWDTAEGAGDEVDRNAAKDAMVTLLNKRSYLRNLVRDVNQALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV3</accession>
    <name>E8WVV3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3711</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582021.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3711"/>
    <dbReference type="EnsemblBacteria" id="ADW70712">
        <property type="protein sequence ID" value="ADW70712"/>
        <property type="gene ID" value="AciX9_3711"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3711"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_2_0"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24708" checksum="40F38CA708710F95" modified="2011-04-05" version="1">MINALLCDIDGTLVQSNWLHAEAWQVALAEMGIQVELEEVRRQIGKGGEELVPVFVPWWKRKHVQEPLEAYRKFIFQQDYLSKVEPLPKVHEFLLRLKDAGIRLSLASSASKEDLLVYKKIAHMEDLIEEESSADDADRAKPHPDIFQATLKRLKLKPKEVLALGDTPYDAEAAGKAGIWTIGVETGGWSREDLLAAGCVEVYKDVAALLECFDQSALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW32</accession>
    <name>E8WW32_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0264</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578666.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0264"/>
    <dbReference type="EnsemblBacteria" id="ADW67338">
        <property type="protein sequence ID" value="ADW67338"/>
        <property type="gene ID" value="AciX9_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0264"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_0"/>
    <dbReference type="OMA" id="QETQCEQ"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="140"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="47028" checksum="DE071FA50E8D3C6F" modified="2011-04-05" version="1">MAETFISQAVTPEETVARFADLHPSFDRQAALAEANRCLFCFDAPCMTACPTHIDVPKFIKKIASENLGGSARTILDANVMGASCSRACPVEVLCEGACVMHRYNKQPIEIARLQRFAMDAFHAPGTNLPFTPAADTGLKVALIGAGPASLACAAELRKHGVAATIFDARALPGGLNTYGIAEYKLPLAESLREIDMIARLGVAFEFGMTVDAAGMAALEAEYDAVFLGMGLGAIHRLGVSGEELEGVTNALDLIEGYKDGSITTVPASVAVVGAGNTAIDAAIAAVRLGAEEVHMIYRRGPEQMSAFDFEYEHAKQEGVQFLWHMAPAGIEGDGKVEGLRLALLENAEDGSLVPRPGGEFTLPVDMVVLAIGQATHTSFLAGGSVKLERGRVLIERTTGQTTNPKFFAGGDCTNGGREVVDAVADGKRAGMGIVAMLKSKEAAAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW53</accession>
    <name>E8WW53_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0287</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578687.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0287"/>
    <dbReference type="EnsemblBacteria" id="ADW67359">
        <property type="protein sequence ID" value="ADW67359"/>
        <property type="gene ID" value="AciX9_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0287"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165560_0_0_0"/>
    <dbReference type="OMA" id="WPVACGR"/>
    <dbReference type="OrthoDB" id="2082442at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10903" checksum="431A760E5C70D84D" modified="2011-04-05" version="1">MQGMRDLLKKELGRSLQGLSELDRLQAAWPVACGRQLAERARITAFESGTVQIEAEDNVWLAQLLSMRAMLEVELAKIAAVKLSGIHFYLKSFRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC5</accession>
    <name>E8WWC5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1455</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579829.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1455"/>
    <dbReference type="EnsemblBacteria" id="ADW68508">
        <property type="protein sequence ID" value="ADW68508"/>
        <property type="gene ID" value="AciX9_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1455"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_0"/>
    <dbReference type="OMA" id="MHDLYVD"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="27326" checksum="BC95B346E821EEE6" modified="2011-04-05" version="1">MNRFEGKVVIVTGAGSGIGAGTARRFLQEGASVALNGRREHKLRETLEGFDQAKTLVHAGDVSDEGYVKSLIADTVRRFGKLDVLINNAGIAIFGPFEQTTTQDWRKVLSTDLDSVYFTSREALPHLLKTKGSIVNLSSASGIGGDWGMSSYNAAKGAITNFTRALALEYGSRGVRVNAVAPSLTSTEATGELEKNEAVLSAFRERLPIGRAATPGDIAGVIAFLASDDAVFINGVILPVDGGLGASNGQPNFLNLLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC9</accession>
    <name>E8WWC9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1459"/>
    <dbReference type="EnsemblBacteria" id="ADW68512">
        <property type="protein sequence ID" value="ADW68512"/>
        <property type="gene ID" value="AciX9_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1459"/>
    <dbReference type="eggNOG" id="COG5654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1353043_0_0_0"/>
    <dbReference type="OrthoDB" id="2127063at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="21531" checksum="4ABDD1F1D5F15637" modified="2011-04-05" version="1">MTFTAKQRAAIKSWIGTAGPVTETFFRSVERRWMDPDDVLSGEGTVASGGRFAAVGVRAVYLSTTDTGASKETTARKSRLGGSALISTAKYPRVVFAVTARLERVLRLESLGSSGPGGDVRKACLDESDLTASVYVATQLEKAGIQGVIFPSVVEGGDDNLIVYVANCKAGALRIQNEDEFIQEATKIAAKRQGLQLLNDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT0</accession>
    <name>E8WWT0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein family UPF0324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0336</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0336"/>
    <dbReference type="EnsemblBacteria" id="ADW67408">
        <property type="protein sequence ID" value="ADW67408"/>
        <property type="gene ID" value="AciX9_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0336"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033541_2_0_0"/>
    <dbReference type="OMA" id="FGLWCAI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="36523" checksum="38A39471EEE0AC74" modified="2011-04-05" version="1">MTQELTATDDYLFTETVEELGQTGPGVPKKAFDARSIFFLGLLLAGSGLVSPPVALVGGIAFGFSVVHPYRKEASSLAKLLLQISVVLLGFGLNLQQVIHAGRSGFVYTAVSICCAVGLGLLLGKVFKVGGKASYLITLGTAICGGSAIAAIAPITDANEEEISVSMGTVFLLNSVALLVFPAIGWWLHLSQNQFGLWAALAIHDTSSVVGAAAKYGPQALAIGTTVKLARALWIVPVSLVTAAYMSRAARREGRQGQVAKVKVPWFIFLFVGASVLSTYVPRLMGIYLDLNRLGKAGLTATLFLIGTSLSKKTLQAVGIKPFLQGVILWVMVGTVSLVAIDMGLIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT5</accession>
    <name>E8WWT5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0341</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0341"/>
    <dbReference type="EnsemblBacteria" id="ADW67413">
        <property type="protein sequence ID" value="ADW67413"/>
        <property type="gene ID" value="AciX9_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0341"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_0"/>
    <dbReference type="OMA" id="VIRTERM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="285"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="454" mass="49179" checksum="3B092D6792240633" modified="2011-04-05" version="1">MDLSVLPDIFALSLLIGAYRPLVRRAGAHVNLWFVGWAFVLVQAFAVLFEGPPGLRRMVLHLVGVAALELCGVAFILAAANSPKRAIRPLLAFEMALPLVAQVALSGFAGAGFEAARYVVSALFVVPLLHVLSHRLSRRQGLMPLGIVFALFGIVNLPVVVRDPGMVTVAALAMVYLSAAYVCLRNATRLSKGVVTTVVGMALWGLKYPFVAAMHHFYPGVHLEHGLMVLPQYAVVAGSILSLLEEHVIRTERMAMHDALTDLPNRRLFEERFAAAMEEARREKTTIACLVIDVDDFKHINDTMGHAVGDELLRALAVRLSWHMSPRDILARTGGDEFTAMLAGVTDEHHLRFIASAMMSAASVPIAADGRSVDVRISMGIALSPDHADDIEGLREAADEAMYRAKRRGGNLLAFAGDAKDKDDLMVARPAHVPAPILQMKLPMTGGRGRASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX15</accession>
    <name>E8WX15_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1523</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579895.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1523"/>
    <dbReference type="EnsemblBacteria" id="ADW68576">
        <property type="protein sequence ID" value="ADW68576"/>
        <property type="gene ID" value="AciX9_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1523"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_3_0"/>
    <dbReference type="OMA" id="FDWGGVF"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="24169" checksum="5116AA94708F79FB" modified="2011-04-05" version="1">MQPEDQKKPVIEAVLFDYGLVLTGPPDPAAWAEMQHLLALDEATFSHAYWKHRSDYDRGTLNGRGYWSAIGQDVGHVLAAPQIDGLIAADTVLWTQLNQPMVDWALRLQAAGTRTGILSNLGDEMMHGVLAALPWMAGFDHLTFSHHLLLIKPEAAIYQHAASGLCVPAERILFVDDREENIAGAIAAGMQAIRYETQPAFEQALAAMGATELWTTGNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX38</accession>
    <name>E8WX38_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ctaB</name>
        <name evidence="8" type="ordered locus">AciX9_2655</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2655"/>
    <dbReference type="EnsemblBacteria" id="ADW69680">
        <property type="protein sequence ID" value="ADW69680"/>
        <property type="gene ID" value="AciX9_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2655"/>
    <dbReference type="eggNOG" id="COG0109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_0_0_0"/>
    <dbReference type="OMA" id="QFFWQFP"/>
    <dbReference type="OrthoDB" id="1875497at2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="35103" checksum="EA910B0B193D11E0" modified="2011-04-05" version="1">MAHSAATVEIPVETKVEPSLLSDYATLFKFRVSTMVIITAAAGLYLGDLRSGLSPFHPESLYALAGITIVTAGSSALNQALERRSDARMPRTARRPMVTGRISLPHGLILGFLAIFLGSLWLAIETNLLTGTLTLLTATSYVAIYTPLKRITSLNTFIGAFPGALPPLIGWTAARGLIEWPAVALFAMIFVWQFPHFMAIGWMYRDEYRHGGIRLAATQQPITWAARSTVFQALFYAVLMLPVALWPSFLHLTGMPYTIAATILTLGYLWYTIKFASILRDPSSPDSRVQARNLLKASVIYLPLLLGAMILNAQGRVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX78</accession>
    <name>E8WX78_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">AciX9_2696</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581035.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2696"/>
    <dbReference type="EnsemblBacteria" id="ADW69720">
        <property type="protein sequence ID" value="ADW69720"/>
        <property type="gene ID" value="AciX9_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2696"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_5_2_0"/>
    <dbReference type="OMA" id="RIHYHED"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="530" mass="55992" checksum="23EA32C49B25E0B1" modified="2011-04-05" version="1">MSDMHENDLRIQYHDQMPRGARIKVIGVGGGGNNAVNRMIAAHVEGVEFIAANTDVQALQVSNAPVKLQLGVKLTSGLGAGANPDVGRRAALEDSDKIIEALEGADMVFVTAGLGGGTGTGAAPVIASLASEMGALTVAVVTRPFAFEGKRRMMQAERGMQELLESVDTVIVIPNEKLLAVAKDAGFFESFRIADDVLRLGVQGISDIITIPGVINRDFADVKTTMAGMGYAVMGTASRTGENRAREAAVAAMASPLLEDGAIDGARGILINITGSSSLKLSEVNEASSIIQSAAHEDANIIFGAVLDESMGDEVKITVIATGFKPQGQDGLSDRRERMLAGTTLPTARWDVPIAPRVNTPRVEVGSAPEPVPVIFPAAEPQKPAEPQQTATPAEPEAAPAQMEVQAETQTEVQPQAETPAQPEIKAHSPELIPVPRSVFDDDFFRISARERAAEHDIAPESNRVRGSDGSDFARPGRVQYVEGGQDTHSHQAFGVPEPVVRVPSFSGAMAPEPVESDELDIPAFLRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE9</accession>
    <name>E8WXE9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578810.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0410"/>
    <dbReference type="EnsemblBacteria" id="ADW67482">
        <property type="protein sequence ID" value="ADW67482"/>
        <property type="gene ID" value="AciX9_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0410"/>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_1_0_0"/>
    <dbReference type="OMA" id="SLWYRVR"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="468" mass="52237" checksum="F3C1BCAED62EC110" modified="2011-04-05" version="1">MPKQDPFELLEVEGHQVRITNPDKPYFTRETKLSKIDIVRYYLSVAPGALQGIQDRPIVLKRFVNGAEQEPFYQKRAPSDLPAYLRTATLSFPSGRTAEEVVVDTAPGLAWIANLGCLELHPHPVRTGDLDHPDELRVDLDPGPGVEWPDVKAVALEVEAVLKENNLIGWPKTSGSRGIHINVRIHPQWTFTEVRRAALALARAVERRVPTLATSKWWKEERHGVFLDYNQNAKDRTTCSAYSVRPLPDARVSAPLFWHEVPQVEPADFTVLTMPTRFATLGNPHAEMDANPGGLEALLELAARDESEGLGDAPWPPHFSKQEGESKRVAPSKAKSFSSQINEGFGAYRFKKQSKAAEPDQSSADPSAEAKPARKARTSRHPLITISQSPDKAAAEAGLERWKLLYPIAAAALTPEDILVDRMRGASYVWYRIRVNLKNVPEPDRPPQQTPDPDDDPTRAWKDQEPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM0</accession>
    <name>E8WXM0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1583</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579955.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1583"/>
    <dbReference type="EnsemblBacteria" id="ADW68636">
        <property type="protein sequence ID" value="ADW68636"/>
        <property type="gene ID" value="AciX9_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1583"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044315_3_0_0"/>
    <dbReference type="OMA" id="YWLGEVN"/>
    <dbReference type="OrthoDB" id="1425729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230428" evidence="4">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="5">
        <location>
            <begin position="186"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34125" checksum="CF03607E9702B2D1" modified="2011-04-05" version="1">MRNLRLTLVCMTALFTIAPAFAQSKDTIRLQTQIQEVQDSVARLQQSNDERMGVLKDLVQQSADSVNRLSVNVDALQKQLAAQQNAQGGKTDQVSGQVQGINDSIDEIKARMVRLEKILNDVQSQQQTIGAALQNNAPASGSPAPSQPDAQPQPQPYIPPTSALPPTTTRGGKPSAAIPQAADGPTAQELYKSAYGDYMAAKYPVASSEFGDIIKAYPNDTLAGNAYYYLGEIDYRAGKYATAARSYDRVLEQFPDNNKIPAAYLHKGQALIELKQTDAGVRELRALIQRFPSSPEATQARAKLNALGVPARPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM6</accession>
    <name>E8WXM6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1589</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579961.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1589"/>
    <dbReference type="EnsemblBacteria" id="ADW68642">
        <property type="protein sequence ID" value="ADW68642"/>
        <property type="gene ID" value="AciX9_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1589"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_2_2_0"/>
    <dbReference type="OMA" id="SWTYIFR"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="121"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="27200" checksum="2988885E17CF72E1" modified="2011-04-05" version="1">MTLLTLLQTAASDLAAPAPITPAHTSALGDMLHNSGPVAMTVLIVLGLASLLSWTVMISKWRSFGAANTQSKRFLRAFRKSGRLSEISAVAEQFRPSPLVAVFTEINDEYYRQTNGRGLPKNPNGLERAAATASSEALTVMEERVTWLATIANIAPFIGLFGTVMGIIDAFHGLGASGTATLRAVAPGISEALITTAAGIVVAVPAVVGYNHLTSQLRDFAARTDDFGRELLNAIENAAAFQPMNPGAPEERRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP2</accession>
    <name>E8WXP2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1605</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1605"/>
    <dbReference type="EnsemblBacteria" id="ADW68658">
        <property type="protein sequence ID" value="ADW68658"/>
        <property type="gene ID" value="AciX9_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1605"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_0"/>
    <dbReference type="OMA" id="VWAVGKT"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27545" checksum="8CF2F976F6CE88AC" modified="2011-04-05" version="1">MPAPLQDRRILITRAAGQASTLATLLAERGAIPILIPTIELAPPTFWQPLDQAIQTIQTYDWLLFTSANAVEAYVQRARTLNLPAQARRIAAIGPATARAVQGTGLAQAVDLIPARYVAESFAEALLPHAPNARMILVRAAEARDHLTQTLMAAGAHLTIAEAYRTIVPPASIEALKYAFSNQAEPLDAITFTSASTARNLATLMESAALLIPHGTTLASIGPITSQAMRDLNLTPTIEAKDSTIPSLVEALTQLFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU7</accession>
    <name>E8WXU7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2768</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581107.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2768"/>
    <dbReference type="EnsemblBacteria" id="ADW69792">
        <property type="protein sequence ID" value="ADW69792"/>
        <property type="gene ID" value="AciX9_2768"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2768"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_81_0"/>
    <dbReference type="OMA" id="VQVWVNI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="272"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="53869" checksum="43A04B02E1655DA1" modified="2011-04-05" version="1">MVTEIETPAALYTEAFAPAKPTPRCEIIAALKTITPLEGLSDEEYAWLADNGTERTGESGAIVFREGEPACNMNFILKGEIHVRRRHSGPMAFFVGRAGAMTGLLPFSRMKTYGGEGYTSGPVWVLDIHSRQFPAMLEAIPSMGQRSVTVLLDRVREVTRMEQQSEKLAALGKLAANLAHELNNPASAAQRSAASLFTELREYGDRKYRMGTLCLDREQSQKMQQWVERTRAEMSAYRRPSEDGPLALADREAEVTTWLDAHNIPNAWNIAPALAETGLPLRVLEEFAEEFDGEILAAAMDNFASSLRVERMAETIVGSTVRIFDLISAIKDYSYMDQAPIQEVDLAQSLENTLSMFRSRLQGITVLTDFDPALPPISAYGSELSQVWTALIENALDAMPNGGRLNLKTKLAGLMAVVEVWDSGAGIEPDLQTRVFEPFFTTKAPGSGLGLGLDQAQRVVSKHSGFLTVVSKPGETCFQVRLPLDQAQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ4</accession>
    <name>E8WXZ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp/Fap pilin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0461</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578861.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0461"/>
    <dbReference type="EnsemblBacteria" id="ADW67533">
        <property type="protein sequence ID" value="ADW67533"/>
        <property type="gene ID" value="AciX9_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0461"/>
    <dbReference type="eggNOG" id="COG3847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171854_8_0_0"/>
    <dbReference type="OMA" id="MITYYYL"/>
    <dbReference type="OrthoDB" id="2065691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6051" checksum="9B97D5405F29B300" modified="2011-04-05" version="1">MKNVKNVIAALLNDESGQDLIEYALVAGLIGLGAVVAMTGLSGKIQSSFNSVGSSLTNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY24</accession>
    <name>E8WY24_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0491</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578891.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0491"/>
    <dbReference type="EnsemblBacteria" id="ADW67563">
        <property type="protein sequence ID" value="ADW67563"/>
        <property type="gene ID" value="AciX9_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0491"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_0"/>
    <dbReference type="OMA" id="INVFPST"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="16"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="30957" checksum="983B6E498DD1B959" modified="2011-04-05" version="1">MNLGLTLLWMSGPELIAPKCSACKDGVKQPFPMTMAFQPIVDVLESRVYAYEALVRGIKNEPAGVVMAQLTEENRYAFDQSCRVAAITLAARLGLKDTGAKLSINFKPGAVYSPSACIRLTLETARALEFPLDLLIFEITEMEEIKDRNHVLKIAQEYRRHGFQMAIDDFGSGYSGLNLLADLTPEILKLDMDLTRNLHERPTALAIVRSTVELCRALGVTCIAEGVETLEELRALRSCGIRLMQGYLLARPAFEALPTVQYPDSCDVSSARDAPSQTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB9</accession>
    <name>E8WYB9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581140.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2802"/>
    <dbReference type="EnsemblBacteria" id="ADW69825">
        <property type="protein sequence ID" value="ADW69825"/>
        <property type="gene ID" value="AciX9_2802"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2802"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1658358_0_0_0"/>
    <dbReference type="OrthoDB" id="2025747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="19387" checksum="C769CA72A7B3E688" modified="2011-04-05" version="1">MQSKNPDSTSLQSSKQAPTPNHAPHVARLSDESGSALVDFSLSIILFLLVVFGIMDCSRALFVDHFIAVSARQATRYAMVRGSSWNGIACSSKPYACTATSADIAAYVMTLVPMGVDPSRLVVNVTWPGTMSSGTQCTGGGAAVNQSGCIVVVNVSYPFSFVLPFMPRSAWAFGSRSSMTIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC1</accession>
    <name>E8WYC1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2804</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2804"/>
    <dbReference type="EnsemblBacteria" id="ADW69827">
        <property type="protein sequence ID" value="ADW69827"/>
        <property type="gene ID" value="AciX9_2804"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2804"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_2_0"/>
    <dbReference type="OMA" id="FRCICCD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="22129" checksum="A25B599D8B755BEE" modified="2011-04-05" version="1">MYPNGSGERPISEGMAMSEIRDRRAFLATAALAVGGAVAWSMRSKPALAASDAELPPMVTVVEFGADGKRIGPRSVARVVKTEGEWKQQLSSISYDVARTEGTERPYSGESWDEHGKGIFQCVCCGTAAFSSETKFESGTGWPSFWAPIAKENVVEKRDSTLGMVRTAISCRRCAGHLGHVFDDGPQPTGLRYCMNSAALKFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG8</accession>
    <name>E8WYG8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2851</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581189.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2851"/>
    <dbReference type="EnsemblBacteria" id="ADW69874">
        <property type="protein sequence ID" value="ADW69874"/>
        <property type="gene ID" value="AciX9_2851"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2851"/>
    <dbReference type="HOGENOM" id="CLU_2478979_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9418" checksum="E513F6414DFF620A" modified="2011-04-05" version="1">MSLFRLQITLSGDDAGKLERLRTVLEGCRAVGSTMTSESPVDSLVFYTEAADSETNVSQFYTDLIHTAVDEDATVEILEMGLEQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL4</accession>
    <name>E8WYL4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578940.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67612">
        <property type="protein sequence ID" value="ADW67612"/>
        <property type="gene ID" value="AciX9_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0540"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099824_1_1_0"/>
    <dbReference type="OMA" id="WRIIGTG"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="24667" checksum="E42CFA5617705B06" modified="2011-04-05" version="1">MQTGKMRKQRVTGSGRHAGHAGANRRNVVELDVHQRVTRQPGMQTPVLVLNASYEPINICGARRALVLVLKGVARTEEAQGAILHAAKVNVAMPSVIRLLEYRRIPHQTRALSRKNILLRDRNCCQYCSVILTAGELTLDHVIPRSRGGLSTWENLVACCHDCNRKKGNQFLHELTEMKLQREPRPFSLHTSRHIMRMIGSADPSWRRYLYFESGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ9</accession>
    <name>E8WYQ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1696</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1696"/>
    <dbReference type="EnsemblBacteria" id="ADW68745">
        <property type="protein sequence ID" value="ADW68745"/>
        <property type="gene ID" value="AciX9_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1696"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_2_0"/>
    <dbReference type="OMA" id="ELIVVMM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="15647" checksum="693DD63407F2DE3A" modified="2011-04-05" version="1">MVTMVRSTNSGAEREDGFTLLELMIVMVIIGILAAIAIPSFTMNVKRAREAVLREDLHTMRTAIDSYTYDKQKAPQTLDDLVQSGYLKVMPQDPFTHRSDTWMPDQGNQLTTVDETQSGIDDVHSGSQDVSTEGTSYNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX1</accession>
    <name>E8WYX1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580126.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1759"/>
    <dbReference type="EnsemblBacteria" id="ADW68807">
        <property type="protein sequence ID" value="ADW68807"/>
        <property type="gene ID" value="AciX9_1759"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1759"/>
    <dbReference type="eggNOG" id="ENOG502Z7M7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559923_0_0_0"/>
    <dbReference type="OMA" id="IIDLAWD"/>
    <dbReference type="OrthoDB" id="526571at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="55"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="434" mass="48077" checksum="3B83F42374A132AA" modified="2011-04-05" version="1">MFACGGWFRGGRVWVLGLAAVLLCPRAEYAYSVQTHEQLIDLTWKPSIVPLLMSRFPNLTPAQLNEAHGYAYGGSAIQDLGYYPFGNEFFSDLLHYVRTGDFIRSLLRNAKTPDELAFAIGALSHYVGDTTGHAQATNVAVGMEFPKLAAKYGRSVTYDENPHAHVQVEFAFDVNEISKHRFAPSAYLAKAGLGVSMDLLGRAFFETYGLRLKDEIGSGKRPRMKAYNFGVRRFLPRIAYAETVLHRHSMPDDVQDEEYWKLENALAAVSMDDKWDLYRKHAGIGTYSLAGLIFVLPKFGPLAMLKIKGPSSAGEQDYVKSVNNSVTRMNKVLVELKAGDLATVMNDLPNRDLDTGLRSAPGTYRRTDLTYAKLLGQITAPDHGIKVPTGLRDDIQGYYADAKAPNAAKKDEQTWAKVQTDLVTLKTVPTVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX4</accession>
    <name>E8WYX4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2866</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69889">
        <property type="protein sequence ID" value="ADW69889"/>
        <property type="gene ID" value="AciX9_2866"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2866"/>
    <dbReference type="eggNOG" id="ENOG5033ARQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592251_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="17934" checksum="24F1698FFBCBF344" modified="2011-04-05" version="1">MRKAVRVLAEHGIPSLVVGGYAVQEHGYARFTSDVDIVVPDVAAAMERLSISGFRVNPGSSMTLTDRVSKVEIDLLPGDGAVGPGPLMLPLPAVVSEEPTIATLRTLIEIKLSSYLGSPVSRLRDLADVIELIKANDLDESFALHEAVAGKFIEVLRDMRAEGNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ70</accession>
    <name>E8WZ70_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig domain protein group 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0601</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0601"/>
    <dbReference type="EnsemblBacteria" id="ADW67672">
        <property type="protein sequence ID" value="ADW67672"/>
        <property type="gene ID" value="AciX9_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0601"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228048_0_0_0"/>
    <dbReference type="OMA" id="KGTTQQF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="PTHR23019"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="78"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="175"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="261"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="462"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="551"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="635"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="726"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="898"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1177"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1264"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1351"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1438"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1611"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1699"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1787"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1873"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1959"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="2045"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="2131"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="2221"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="2308"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="2394"/>
            <end position="2475"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="2480"/>
            <end position="2563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2570" mass="252842" checksum="66FE433D77A90192" modified="2011-04-05" version="1">MGCWRRGCTFKGPATIPHKCHVTFGTKWEAMLKFTGLAPITASEGFHPMIERIRTCSVFSVVLLLMVSLISGCSSSPSNGSILIAGGSSTLVVGGTMQLHATDTNFLHVVSDATATATWSSSNPAIVSVNSTGLVTGVTTGYATVRAQLGQDSGAFVVTITSSSGSGSGGGGGTTGSTLTLSPANANLFMGGAQAYSATLTSSGGTVTNVTSSTTWNVTPASVATINSTGMLTPVGPGNYLVSGTNGGVTGTALGTVSAVTLTSLAVTPATSTLAGGMTEQLTAIGTYNDGSSRDLTKTVAWSSSASTALTVDANGLATAASTSASTSVTVSATLASGAASVTGTATVQVTPDAYITDLVVRPTSSSIATGSAEQHTATAWYSDGTQQDVTKQVTWTSTNSGTSAVNSSGINVAATPGVTTLQATISKTGALFSANAVGANASPQATANVQSSSVVIVTPATVTSLDIGTSKAQFPIGSTQPIKLIGTFSDGSTQDLSLSANWQSLDPSIATIDSTGVATGVSAGKVVFTANFGGLVISTDGFEVLPTDLISTTVSVDYAGQITGLSEQLHVIGTYADGSTHDLTGLASFVSSDATIFAVNSTGLANGIATGVAQITATVAGFSAITNVDTYVETISTMGVFPQQPRFALGTHLQLAASITADDPITGVFSQDVTGSAVWTSSDPTVLTIDQNGLAKSGKVGTTTVFATVLGTTKYSDTITVTNAQLQKIVLSKQPASIAMGTANQYYVTGFFDDGSVQDLTLDAVWNTDDNTIASVDKDGTTLGLKPGQTQVTASMAGKTATAALTVTGATLVSTSLLPGNVEVPINFYTQYSMIGTFSDGTTQNLNYGTIFQSPTPFIASFFPVGLGGTNYPGIGQLTGQYGYFSASTPITVSNANLTSVTLSPAKSTIRVGDSQQLTTTGIFDDGLQLDLGGEAYLISSAPLIAPATRTGLIYGTSVGTSTFTANMYGTTATATVTVLSNVLTSLTLAPNSPAVVSGSTQQLVATGIYQDGSTDDLTNSVTWTSSNPSLLSVNASGLAMAAAGTTSGTSVTVTATAAATLAHPAVTSSFVVTIQPSGSGGTGGGGTTSPTAMQVTPTRTHLAAGTTKQLTATATYADGTTKDISSTVTWTSTNPLTATVSSTGLVTAVKTGTVSVQAQTGTLSSSSIVVVSSATLQSLAISPSGATFAAGATQQFTLTGTYTDGTTQDLSSGATWSTSNAAVATVSSTGLATGVGPGTVQFSASYGSLTATSASNTVTPLTLVSITLTPTNPSFAKGTTQQFTVTGTYSDGSTRDITSSSTFAASNPSVVSVSTTGLATGAGVGSAQITVSVGGQTASTQSVTVTPAVLASITVTPKDLSFADGTTQQFTAIGTFTDGTTQDLTHQVVWSSSDAQAITIDQNGVATGGSVGSAQITATMNSVSASTDIIKVTPATLISLILSPTTVQLAKGTTQQFVATGVFSDGSSQNLSSTVTWTSSNGAIASVDGNGLATGTGTGSAQVTASYQGKMASTTSFTVTPATLVSLSFNPANPTVASGTSTHVTVLGVYSDGTTQNLTSTATFSSSNTTVASVGAAGVINGNLPGSSTITVSAGGQTGSFDVAVSAAVLTSLTITPANPPAFAKGTTLQFTATGTFSDGTTQNLSTSATWVSSNTSVFTIDGNGLASGVGVGSASLTATAEGQVAMTPAFQVTPAVVASIAVSPQSQTVTAGTLLQYSAVATYTDSSTADVSSSAVWASSNTAAATINATGLATSVAAGSTTISATVGSVTGDAGLTVNAGAVTLSSITVAPSSASIAKGNTQQFTATGTYSDGSTRNVSTTVTWQSSVTAVATIDGNGLATSVAGGNTQIWASLSGRSAMATLSVSPATLVSLAVTPQTASVANGTTQQYKAVGTLSDGSTQDLTTSVTWSSSSSAQATINASGLASTTGTGMVTITAQAGSASSSATLTVTSATVTSLQITPSPVSVPAGGSVQLLATATFSDGSSQNVTSSVTYSSSNPAVVTVDSNGKLKAVGPGNAVVTATLGGTTVMLPVTIGNATVTSITITPANPSLAAGTSQQLTATATYSDGSTQDLTNAVTWSSSDPGAVSVNTTGNITAAQPGTATVTATYGGATGSVNVTGTAAVATAISVSPANATLAAGQTKQFAATATMSDGTQQTVTTSVHWGVSDPSKASVSDSAGSNGLLTATAAGSLNVIASLNGVSGPAAVTVQAATLSSLTINPSAVISLPAGTTEQLSVTGAYSDGSSADVTSLVTWSSSQASTAYVDASAVLHTGTSGLTTIDAKLQGVDGTAAVTVGNATLSSIAITPAAPVLALGQTQQLTATGTYSDGSTANITTQVQWNSSAPAVATVSGGGLVSSLTTGSAAVTATLNGVSQQTPVTVTSATLQSIAVQSPQSSFALGTSLQLKALGFYSDGSTQDLTNSVTWSSQTPAVGVISSTGVATGVSAGTFNARASLNGVTGSTPITVTSAVLVSLAVTPNNQVILNVTTTTVQFTATGTFSDGSTQNLTNSAHWGTSGIVVGSISSTGVFSPTGVGVGTVTATSGSVTGSTQITVVSVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ88</accession>
    <name>E8WZ88_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579018.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0619"/>
    <dbReference type="EnsemblBacteria" id="ADW67690">
        <property type="protein sequence ID" value="ADW67690"/>
        <property type="gene ID" value="AciX9_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0619"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_1_1_0"/>
    <dbReference type="OMA" id="NSCLMHI"/>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="27417" checksum="3AE6944E261CB057" modified="2011-04-05" version="1">MRVSLFITCYNDTLFPDTGKAVVRVLERLGHTVDFPAGQTCCGQMHYNTGYQADAMPLLERFVEQFRNSEAVVVPSSSCVAMMRDHYPIMAAQIASQGKHPQLVREVEALLPRVFEFSEFLTQRLGLEDVGAYFPHRVTYHASCHGLRNLHLGDGPQKLLRAVRGIDLVEISGLEQCCGFGGTFAVKNAEVSSAMLAEKTTAILNTKAEVCTACDNSCLMHIQGALHRQRTGVRTLSLAEILASDEGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ98</accession>
    <name>E8WZ98_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0629</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579028.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0629"/>
    <dbReference type="EnsemblBacteria" id="ADW67700">
        <property type="protein sequence ID" value="ADW67700"/>
        <property type="gene ID" value="AciX9_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0629"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005647_0_0_0"/>
    <dbReference type="OMA" id="AFWLMEG"/>
    <dbReference type="OrthoDB" id="76786at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="365"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1229" mass="137332" checksum="E8C576F7818DFDD7" modified="2011-04-05" version="1">MEFHIARSLREKLNIDDLLFSYTGNLVFANVAASRKLAQQLNDLSPEKAAIAPVNAGALFAMGLIDELSHAMIASYRRDIDPAVLTDALAFIEQQTSKAEVEKLLITFTEQFPNTAILRGQITAAKWLAGTTEGLPNREAALEELLLLWLANKNTAFAPFKILFADKTLEENTTYKTVTPTFPTYFASRPQVEIGSLLDALIAPMLASPDSLTGQLDYIREHWSKTLGPELKRLLLAIDVLKEEDIAIWMRFHPPTPDRFGHSEPGRHSHGFVGDEYVGFDEDFVVGADGIRRAKKYDKDHQAPLNEYEAFSQDYAWMPNVVLMAKSTYVWLEQLSKKYLRHIYRLDQIPEEELRLMADRGMTGLWLIGLWERSTASRTIKRLRGQADAVASAYSLKEYRIAEDLGGTQAYEHLRDLAARHGIRLASDMVPNHMGIDSTWVTEHPDWFISRNESPFPVYSFEGPDLSTDSRVEIKIDDHYYDQTDAAVAFRLRQRATGETSFIYHGNDGTTFAWNDTAQLDYSKAFVREQVIQTIFYVARLFPIIRFDAAMTLAKRHVQRLWFPLPGVGGSIPSRAESAISNEEFDALMPNEFWREVVDRVAVEVPGTLLLAEAFWLLEGYFVRTLGMHRVYNSAFMNMIRDEENAKYRSYLKKTIEFDPDILGRYVNFMSNPDEKTAGEQFGDGDKFFGSCTLLATLPGLPMFAHGQIEGFNERYGMDFKQARMDEHPNEGLMGRYQHEIAPLLKKRYLFAGSANFVLYDFWGEHGSVDENVFAYSNRVGDERAVVLYNNAYQSTRGTIHISAASMDKGSGNLVQRSIVDGLAVSTDDGMVLAYRDPVRDLEYLYRASDLRDRGLTVDLRGYGYVVFQNWRQLRSTEQYPWDRLADMLQGAGVRSVEEAISKLRLRPLHESLRHAICASHIAAFDDAAKKAAHETISDAGNKIEKPAPPAAVSELTLEPTPTAPFSTRLKPFVDAGITFADRAKEMLPEEPAAPTPELTTKPAAQPTPEEIATEVSAVTKTPVEPVLAPEPAAPGNTYQQNAEALATALVAQAAAALKTPTPLPANKWPITLAWATIAALPTRPDLTPAEIYDRLYLRSALAEIFNSLGLEGEEAWRAAALVRILLTTPDWTDPDLLWLAGSSQSNGITYLNKERFAELTAWLDLPAILTGAKPKAVDAITALEKAGYRLDRYLAPAKLEAGSSKLTAGQEKPSPTSPISEEVEVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB0</accession>
    <name>E8WZB0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ordered locus">AciX9_0641</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0641"/>
    <dbReference type="EnsemblBacteria" id="ADW67712">
        <property type="protein sequence ID" value="ADW67712"/>
        <property type="gene ID" value="AciX9_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0641"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_0"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="150"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="554"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="607" mass="68467" checksum="87CC5A15D84BFD1C" modified="2011-04-05" version="1">MTLDFLGTLERTHMCGDLRAANDGQPVVLMGWVNRRRDHGNLIFLDVRDRTGITQIVLDKERGAAAHLKAESARPEFVVAAVGQVRLRDADLRNPKMPTGDIEVVATELLLLNDAKTPPFSPAEDAIANEEVRLKYRYLDLRRPEMQHNFRLRHEVARAIRNYLSDDGFLEIETPFMTRSTPEGARDYLVPSRVHAGEFYALPQSPQIFKQILMVSGFDKYFQIARCFRDEDLRADRQPEFTQIDLETTFPSQERIFRIVEGFLTAAFKAANITLQPPFVQMTYDEAIRHYGIDKPDMRLPAMTDLTDTVTPDLRTQLKIEQALPILGFVIPSAGTLSGTQKRSLIEEIRTFFGETGLDFLDVARLKTNETFAPLAAAIADEMKPAEADLVVVITPKLGTPERWNYDPQWIYKKVGALRLELAKKFADKHGLFKQTGTAADYKFCWVTDFPMYEWDEEAKVWQAAHHPFTSPHEDDITSGRLVSDKGAVRALAYDIVLNGTELGSGSIRIHRKDVQAEIFRSLGMSDEEQKARFGFFLDALEYGTPPHGGIALGLDRIVMILAGATSLREVIAFPKTARAIDLMVDAPTPVSDQQLRDLSLRTVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM2</accession>
    <name>E8WZM2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor, CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2973</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581310.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2973"/>
    <dbReference type="EnsemblBacteria" id="ADW69996">
        <property type="protein sequence ID" value="ADW69996"/>
        <property type="gene ID" value="AciX9_2973"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2973"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_3_0"/>
    <dbReference type="OMA" id="YNTVQTM"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15281" checksum="10F723BEF873A6AA" modified="2011-04-05" version="1">MPDDPQTNLTRLELRIMQALWTLGESNVASVQQALDPPLAYTTVQTMLNILERKGKLERRREGRAFLYNPVVTQARASGQGLRDLIDRMFDGSSEELVMSLLKNRQIDADRLTEITERFNAKADPDPTIAKKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP2</accession>
    <name>E8WZP2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">AciX9_2993</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581330.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2993"/>
    <dbReference type="EnsemblBacteria" id="ADW70016">
        <property type="protein sequence ID" value="ADW70016"/>
        <property type="gene ID" value="AciX9_2993"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2993"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_0"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="554" mass="60883" checksum="C9E00CFA72473073" modified="2011-04-05" version="1">MAQDKLRLIPLGGLGEFGMNCMALRWQDDIIVIDAGLMFPEEELLGVDIVVPDISYLTENRTKVKAIILTHGHEDHIGGLPWILSELNVPVYGTEFTLALAEGKLDEHRLLDDADLIEMIPGKKFSIGPFTIQPIHVTHSLVDCVAVAIHTPVGVVLHTGDFKVDLSPPDGKAFDLQAFADLGKNGGVLALLQDSTNVDRKGWTPSERAVRPRLDEIFGQTKKKLFFSCFSSSVTRIALAFDLAAKHGRKVAVIGRSMDNATEIAQDLGYLKVPQGLIINPGQMRDFAPEKLLVMISGTQGEPMSALSRAAVNNHKFAKIEAGDTVLMSSRVIPGNEKGIYRVIDHLERRDALVIHDDGTNGLIHVSGHGSQEELKLMINLVQPKFFIPVHGDYRHLKRHVELALSTGVPQKAILMEDGEILELTKDTAQKNGKVTTGRVCIDSGGTIDVVEDVVIRDRQHLSEDGIVIAIVAIDKRTGQSEGVPEIVMRGFAMDDAQLIGESRAIVKRTLEGSSAEERQDYGVIKEKIRGDLKRFIQKSTSRRPLIMPVIMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR0</accession>
    <name>E8WZR0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome_P460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3013"/>
    <dbReference type="EnsemblBacteria" id="ADW70034">
        <property type="protein sequence ID" value="ADW70034"/>
        <property type="gene ID" value="AciX9_3013"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3013"/>
    <dbReference type="eggNOG" id="ENOG5031DJB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382417_0_0_0"/>
    <dbReference type="OMA" id="PGNWAYF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_P460" evidence="1">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="18838" checksum="D8808355AE6FE481" modified="2011-04-05" version="1">MVNDGPGYLANGEMKFPADYRDWVFLTSGLDMSYSSDAAPDHSMFNNVFVNPSAYRAFKATGHWPEGTVLVLENRGAEGAKSINKRGKTESSELMGLEVHVLDSAHVKGGWGFYGFDNQVSGKLIARPAGCYTCHEEHAAVDTTFVQFYPTLMETAKTKGTLSAAYLKELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR6</accession>
    <name>E8WZR6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ordered locus">AciX9_0656</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579055.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0656"/>
    <dbReference type="EnsemblBacteria" id="ADW67727">
        <property type="protein sequence ID" value="ADW67727"/>
        <property type="gene ID" value="AciX9_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0656"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_0"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="31258" checksum="12754D142C4F9AC4" modified="2011-04-05" version="1">MTALEALTRATDQLSAHPDLRPSALADAAILLTHTLGIDSTTLRAHPERPIDRDQQAVYQRAIERRLTFEPIQYILGTQEFYGLPFRVTPAVLIPRPETEHLVEAVAARVPHNRPVRILDVGTGSGAIAIALAHLLPHAHITALDISPEAIEIAQENARTNHLAARIDFQQSDLFTAVTKGPPFAAIVSNPPYIPLSDSESLHPQVRDYEPHQALFSGPTGFEVYERLIIQAPSLLLPNGLIALEIGQGQQPRMAELLRFWRSVEFLPDLQQIPRVALARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS9</accession>
    <name>E8WZS9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0670"/>
    <dbReference type="EnsemblBacteria" id="ADW67740">
        <property type="protein sequence ID" value="ADW67740"/>
        <property type="gene ID" value="AciX9_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0670"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_4_4_0"/>
    <dbReference type="OMA" id="VEQGTGH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16904" checksum="90DADEBA72FCF968" modified="2011-04-05" version="1">MMKDSKKSEGAPLRPISKLIRRITMGFRTRLDDRLRDHQVTTAQIRMLYELRERPGGSGAQMARACYVSPQSAQTMLARAVERGWVVRGKDPENERLVTMRLTDSGRELLEYAEGVVKAMEAELWEGVSPEELGVVRGVLERVAGRFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X054</accession>
    <name>E8X054_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ordered locus">AciX9_1904</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580269.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1904"/>
    <dbReference type="EnsemblBacteria" id="ADW68950">
        <property type="protein sequence ID" value="ADW68950"/>
        <property type="gene ID" value="AciX9_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1904"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_0"/>
    <dbReference type="OMA" id="DFIYCCS"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="399"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="493" mass="53967" checksum="E166DA3DA27B7BAD" modified="2011-04-05" version="1">MSNESPTKMWSGRFREPLYPGFESWQASFRVDVRLLRHELEASKAHAKTIAAAGILTPEELATTLEGLDSIPKRGAEEATKLTNMAFYAEIMKQRMPGIGMVHSSLGSLPMLYPNAEDIHHYVELQLNELIGTLALKLHTGRSRNEQIATDMRLFVREAIDEVIQGLKNWSVALITLAEQSGETVMPSYTHLQRAEPVLIAHWLLAYVEMLARDISRFQDARKRMNLCPLGSGAIAGATLALDRTITARELGFDAPTPNSMDATSDRDFMLDFTQACATLGLHISRFAEEITLHATAEFGFIDLPEAFSTGSSAMPQKKNPDLTELIRGKSARLIGSATTLSVLIKGLPLAYNKDLQEGQEPIFDAADTVTGMLALLPAFTAALKFKPARLKEAAETGYLNAMAGATYLSNKGVPFRKAHEIIGNAVRLGLESGRELNALTLPELQTLSPEFAEDFYQAITLEATLDCHDVIGGTARPRVSAALVTAKARLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D3</accession>
    <name>E8X0D3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0727</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579123.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0727"/>
    <dbReference type="EnsemblBacteria" id="ADW67797">
        <property type="protein sequence ID" value="ADW67797"/>
        <property type="gene ID" value="AciX9_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0727"/>
    <dbReference type="eggNOG" id="COG4152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="33117" checksum="DD9F11EB95F47E48" modified="2011-04-05" version="1">MAPIVELDNIRKAYDTKIAVEGLSLTIEPGTMFGLLGPNGSGKSSSIRMMIGITRPDSGTVRLFGKPFTRDALSRIGYLPEERGLYKKMRVLDQLVFLGQLHGLSSAVATARAKVWCERMQISEAIGKKTEELSKGMQQKIQFIAALLHDPDLIIMDEPFSGLDPVNATLLMDTLIDLRKQGKAILFSTHRMDQVEKLCDSIAIIFKGRLVLSGSMREIKAGYPANRLLVNYTGDASFLDHPAVERAKTYSGRAELVLSDPTAAQSILVEAIACGTSITRFEVVEPTLEEIFIETVGENVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I2</accession>
    <name>E8X0I2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0777</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579172.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0777"/>
    <dbReference type="EnsemblBacteria" id="ADW67846">
        <property type="protein sequence ID" value="ADW67846"/>
        <property type="gene ID" value="AciX9_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0777"/>
    <dbReference type="eggNOG" id="ENOG50337MA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161432_0_0_0"/>
    <dbReference type="OMA" id="HHALSER"/>
    <dbReference type="OrthoDB" id="1872913at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13470" checksum="389A8D442468CAD6" modified="2011-04-05" version="1">MQTLDLQAYSYEDRQGLIPALTQAFTHSGGWVLERTTTSTSTIEFRLEIQLRGIADLYAALVEAGIELTRTAHATLTDLCTCRQHVMRTAQPNRVISLRLELSFLDDVTLHSLMMTGSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L4</accession>
    <name>E8X0L4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YfiO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1919</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1919"/>
    <dbReference type="EnsemblBacteria" id="ADW68965">
        <property type="protein sequence ID" value="ADW68965"/>
        <property type="gene ID" value="AciX9_1919"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1919"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029598_0_0_0"/>
    <dbReference type="OMA" id="CVATDSA"/>
    <dbReference type="OrthoDB" id="1256747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230140" description="YfiO domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="28004" checksum="7717422FB875610E" modified="2011-04-05" version="1">MNLTDLKSFSKPALALLLLASVAPALHAQAYTPPPPPLTNAPCVPTKKQPCDVPAPAAKPAPPSGLAFPGESDDTPSLPLPSQTTDYSAPIPPAPAKPAQTPASPPSVPDAAKPAAAPGSSSFPFPGDDPAYANPSSSSSSSSSSSSSSSSSSSDSNPDNPPLKDEGSTGTTKAQRRHLPKVEDVNEREAKDLEVAHYYFTTGNYLASLNRAKDAVRLFPDDPEAHYALALAAQNMKNQEQASAEFQTYLKLDPGGDHAKDAEKALKGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R1</accession>
    <name>E8X0R1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1966</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580331.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1966"/>
    <dbReference type="EnsemblBacteria" id="ADW69012">
        <property type="protein sequence ID" value="ADW69012"/>
        <property type="gene ID" value="AciX9_1966"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1966"/>
    <dbReference type="eggNOG" id="ENOG5030JUS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1666937_0_0_0"/>
    <dbReference type="OMA" id="MDTEDIT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="16062" checksum="46FC35357BFE5460" modified="2011-04-05" version="1">MALAAGASAAQVAGTGAILSIGGPTGAGGSEVFVTIGEVKDAKLSGRKTSTTMSTNFASLGIQQKVATITDLGTATFTANRVGNDAGQLAINAAQLTRVPYDFKFQIPPNTVNGQTTGDLITFSGIITEAGSFDVSLDKVSEYTFTVDLNSYNSVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V5</accession>
    <name>E8X0V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581453.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70139">
        <property type="protein sequence ID" value="ADW70139"/>
        <property type="gene ID" value="AciX9_3123"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3123"/>
    <dbReference type="eggNOG" id="ENOG5033K8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530447_0_0_0"/>
    <dbReference type="OrthoDB" id="2023981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19906" checksum="B186726222839AE7" modified="2011-04-05" version="1">MIRPATKLATSLFVAFHLCVMTLFALPMSGNWVERIRVYVSPYMLAIGMNETWNTFAPNPKSAEQFMKAVVVTLRGKTEVYQFPRMEDLSYADRYRMERFRKFEESVVCGDCNGLWPDVGRYVARRSGTPMDPPDRVVLVKFESAIDPNHGLLGEDEHAVPTVLGELSVQPEDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V6</accession>
    <name>E8X0V6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3124</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581454.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3124"/>
    <dbReference type="EnsemblBacteria" id="ADW70140">
        <property type="protein sequence ID" value="ADW70140"/>
        <property type="gene ID" value="AciX9_3124"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3124"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045120_0_1_0"/>
    <dbReference type="OMA" id="GTALHYV"/>
    <dbReference type="OrthoDB" id="1387983at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="13"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="35608" checksum="2AD4DB50A828B10C" modified="2011-04-05" version="1">MQDLRRKADAFFFQPISPYPLAAYRILFGTCVATTLLLLHRDWMAWFGMHGWVSPETIHKAESGFRLNAFDLLPNDDGWVRLCFWIFLSASLALVLGFCSRLSSAIVFLALNALNQRMPLILHGGDTFLRAAAFFLVFCPSGMVWSVDALIRKRRHILRPITIKPWAQRLIQYQLVLIYLSSFLWKIKGEPWRSGTALFYVWHLRELQRFPVPSLFHNSAAVHIESWSVLVFELAFPLLIWLKRFRVSLLTIGILFHLTLEYALNIPMFQWDMLSAYVLFVDPYALERGIRHFFKVWKRRQVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X168</accession>
    <name>E8X168_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0866</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67934">
        <property type="protein sequence ID" value="ADW67934"/>
        <property type="gene ID" value="AciX9_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0866"/>
    <dbReference type="HOGENOM" id="CLU_1914113_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14661" checksum="FC52D29172F59CF2" modified="2011-04-05" version="1">MRKGRVADNADMDSKSFAAAAYRVEHPSKINRRSRRGTTPQAVRVDQIHARDPLAYPSSRPRPEGATKPLLSFEWTETKATATPVVEAEVPVAAPSEPVRLMPSQRAHLLRPLTLRGSDGRQTYVTYTVNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B0</accession>
    <name>E8X1B0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580382.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2019"/>
    <dbReference type="EnsemblBacteria" id="ADW69064">
        <property type="protein sequence ID" value="ADW69064"/>
        <property type="gene ID" value="AciX9_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2019"/>
    <dbReference type="eggNOG" id="COG5283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289313_0_0_0"/>
    <dbReference type="OrthoDB" id="1006982at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1060" mass="109553" checksum="F16253C34CEE8402" modified="2011-04-05" version="1">MANTASFSAGMTKMGQLSATTGKNIERSFKLVGTAAAGMAATIVASLTTAIAKGEDFAFTVSKMAQQTGTTTEMFSKLAYSAKQVGIPLDTLKGSLERLARTSGAAQSGNKEAIAAYGALGISVKDLNGPLKNSGDLLVASAKSLNQFGDSANKTALTQKILGRSGAELAPLLSQLATGFDTASAKATLFGVVIGDKTAAQAVKLHQSMTELESIALGFSLRLLSGVSPALQDVSAKLVKVATSADGMQTVSAIASNVATVIRDLGDAFFFLSQHTTAVKVAFEGISALQIGSILVPLVAGAAKAGTGLDTVGLAAVKMIGRLSGVSQVLPLISSVTSAVQVQAFMFRTLAQEEGTAVAATYALSTAWKSLTASMLANPGIVALGLLTAGAYVFQKALTDDVAASAKLSDAAVTFADYWKAAIDQTKDRMEELKTILFTFDESKRNAALSQWGEDPTFGERVHMEANTRLVAAKPAAPVPVTPKLNAPPIPKEAAERVDIVAKKLMELRDAAAAARQSLADAGKGVDFERADEAAKESKKTIDELNIALKAKGKALTVGQKAEIIADTATRINSESQAKYRSDLVQSTRMILAQVEAHRILTAAVGQGAQAVAQAQVDSESTLNNANQSPQWIKNNKALLDQQKAARLSELSAANTHTDASALDGLTQQLSVQKLINAAILAGRDATNQARLASEQAAIVNAYNGRGDHNDAARDAELAANEKLFNAKNKEADLTRAAGMDAARLYNDEAQSLQNAASAARDAGQAINEMQLKAANKANLDQYIASIEKVNLAVGGMSDGFSVFFEQMARGTESSAQQVHDLLGGAFEGLNGTLEKIVTTHTRTFYEFTRAVKQDFGEMLKGISSSLASLGLKNLESGLAGGLMKSLGIGSKADPTVGAINGTNQRLDVLIGLAGGKSATSAVSSAVSSAAGLGKSSGSWLGGAASSLLGLIPGGGFLSGLGSLFGGHRALGGDVQAGMSYDVGEMGRETFTPSVNGKITPNNKLGTGGNMISIDARGSNDPSQTEAAIHRAMKQYAPTIAAGSVKAQNESRARRPASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F8</accession>
    <name>E8X1F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3182"/>
    <dbReference type="EnsemblBacteria" id="ADW70193">
        <property type="protein sequence ID" value="ADW70193"/>
        <property type="gene ID" value="AciX9_3182"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3182"/>
    <dbReference type="eggNOG" id="ENOG502ZRZF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206689_0_0_0"/>
    <dbReference type="OMA" id="VMFIRRI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6969" checksum="DC52169B0DBE007E" modified="2011-04-05" version="1">MLRFVLDVLLLRNLIQSRTARMLFLIFILGALVAGCIYAFVVFQAISERSNSSHVSTYRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K1</accession>
    <name>E8X1K1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3225</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3225"/>
    <dbReference type="EnsemblBacteria" id="ADW70236">
        <property type="protein sequence ID" value="ADW70236"/>
        <property type="gene ID" value="AciX9_3225"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3225"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029872_1_0_0"/>
    <dbReference type="OMA" id="RYAMIFE"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234081" evidence="1">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="211"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="43940" checksum="3B8F1A19E15C12C2" modified="2011-04-05" version="1">MMIAGSIQRSLLVCVCAVLGLAGTASAAKPKLEDHWVGTWATSPYQMDNAAGTMGGADMTIREIVHVSLGGPLLRVELTNEHGVEPLTIGGAHVALTTGRGDVSLVTSNALTFGGKDGITIPAGATAMSDPFALTLPPLSDLAVTLFVPAQPMTKVTFHGSAFQTNYLAPGNLLSGRTISSADGVKTSTSWFFLKGVDVKTTGDTGAIVTLGDSITDGAQSTVDANATWPDELARRLQGDKKTKGLGVLNEGIGGNRLLHDNAGPSALRRFDMDVLSRPGVKYLVVLEGINDIGHAYDPVKAYDVVTADDIIQALAQLAERAHVMGIKVYGATLTPYGGAKYASPAGEAVRQAYNNWIRTTKALDGFIDFEKVVMDPASPATFPAFSPAFNKADHLHPNDAGYKAMGDAIDLKLFTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P5</accession>
    <name>E8X1P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0896</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0896"/>
    <dbReference type="EnsemblBacteria" id="ADW67964">
        <property type="protein sequence ID" value="ADW67964"/>
        <property type="gene ID" value="AciX9_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0896"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301868_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="10612" checksum="394265573782FBCB" modified="2011-04-05" version="1">MSMRTSEALAGEANGIDLTGRTVLGVVRSMVSQPARVALRSFAEGDTTILLVTVASVDLQVLTGRDGRTARSLRALVNAIGSRPGRRMELEVQGETEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X278</accession>
    <name>E8X278_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0943</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0943"/>
    <dbReference type="EnsemblBacteria" id="ADW68010">
        <property type="protein sequence ID" value="ADW68010"/>
        <property type="gene ID" value="AciX9_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0943"/>
    <dbReference type="HOGENOM" id="CLU_2633121_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="8561" checksum="659BB622D2B280FA" modified="2011-04-05" version="1">MLWALLSSGEGRLRGITLVPGDLMKELRYEDLNEDTQAFLDSCLALNEPLLLTDEDGKGLVKFIPIQPSEQVADNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X290</accession>
    <name>E8X290_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579346.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0955"/>
    <dbReference type="EnsemblBacteria" id="ADW68022">
        <property type="protein sequence ID" value="ADW68022"/>
        <property type="gene ID" value="AciX9_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0955"/>
    <dbReference type="eggNOG" id="ENOG5033UN9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228500_0_0_0"/>
    <dbReference type="OMA" id="WHTFYEW"/>
    <dbReference type="OrthoDB" id="2121265at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="26229" checksum="FCC6DD229F93779C" modified="2011-04-05" version="1">MAVDWVAVQAVATSILVLTSVGAIGYAGLQLRHERNYRSVENLEKQLSFFLSENFVGARRRLAQARLDVSNEDQPALLAWSLEAPPVSVFEVLDFYEHLSLLVKKGHLDVYDVWHTFYEWAQPVYVDMQPLIESAESMYAEHYDDLEHLMRQMDEIQINRMHNQKGNHWALWTPDRIIEHYRYELESGGRPRRTRRVPAREARDIAREVVREIQQSDPDAGPVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B1</accession>
    <name>E8X2B1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579367.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68043">
        <property type="protein sequence ID" value="ADW68043"/>
        <property type="gene ID" value="AciX9_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0976"/>
    <dbReference type="eggNOG" id="ENOG50339C1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164580_0_0_0"/>
    <dbReference type="OrthoDB" id="2179767at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="25221" checksum="4651A4D009870D23" modified="2011-04-05" version="1">MSAKRLAVWLLQDSIDSGHTKLLEIFIGIAAFALLMQAIAVIVVAAAGYKAQKRAMEIVEEVRAKALPLIDKSHGLVEKSQALMADLTPKIQTITANVEQVSTIIKDKVVEFEPTVSAANATVQDANAKTHQQIIRVNGMVTSALNATAELASTIHEGIRTPAREIAGVVSGLKAGIDSLISKTRGFGAGIKPNPVRRPGPVVVKTANPYYQAESSTSAQVKAAASAFERAEKSDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H4</accession>
    <name>E8X2H4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2154</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69198">
        <property type="protein sequence ID" value="ADW69198"/>
        <property type="gene ID" value="AciX9_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2154"/>
    <dbReference type="HOGENOM" id="CLU_3290360_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="40" mass="4335" checksum="7B39D08D52645B69" modified="2011-04-05" version="1">MAADPAAFDPDNARALMTVTGGRTVYELRGISRLPLNLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M6</accession>
    <name>E8X2M6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3312</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3312"/>
    <dbReference type="EnsemblBacteria" id="ADW70323">
        <property type="protein sequence ID" value="ADW70323"/>
        <property type="gene ID" value="AciX9_3312"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3312"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="HDEVQDV"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="257"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="477" mass="53517" checksum="3BAB17165B674918" modified="2011-04-05" version="1">MMQWNLNELRPKKLRTRLTLWYMGVLTLVLLVYLAVVYIFQYGLLTSQIYHDEVQDVETVEGLLRFDSQGELVLDQSYHSHPQSHLLADRLMEVRDFTGTVLYRTDTLHGMTLGKVTQTEDEGDSSFNERTVRLADGTRVLVISHRHPVQGRMLLIRLGYSLSPLMSRMRNFLFALILALPLALVCAGFAGYTIVRKSLAPLDAMASRAEQITAYELSGRLEVENRQDELGRVAVVFNSLLERLERSFTQLQRFTADAAHELRTPLSSIRVVGESALRGDQSAALYRETIGSMLEETLRLNQTVEGLLLISRAEAGEIRLELTSFSVHDLIGDLLSILDVLLEENELIVKEHTLEPSRMMVLADRTFLRTCLLNVLHNAAKFSPLGGTITISYAHVEKHSRPFLRVSILDEGVGLSPDHREKVFERFFRVRDSSLPVGDGAGLGLAIARLAIEANSGAIYFDPTEAQGALCQIEIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X7</accession>
    <name>E8X2X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpt domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1048</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579434.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1048"/>
    <dbReference type="EnsemblBacteria" id="ADW68111">
        <property type="protein sequence ID" value="ADW68111"/>
        <property type="gene ID" value="AciX9_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1048"/>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2221949_0_0_0"/>
    <dbReference type="OMA" id="AIWKENR"/>
    <dbReference type="OrthoDB" id="2023855at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="11422" checksum="29914CA90C764CE5" modified="2011-04-05" version="1">MSPAIQAQTNSLLTGMWNRNIPLMRARLETLDRAVEAARSGSPDPALYQSAVDIAHKLAGSLGMFGFARGTDLARELEAALESHAASTQRLELLVSDLRATIFPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B9</accession>
    <name>E8X3B9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ordered locus">AciX9_3414</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581732.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3414"/>
    <dbReference type="EnsemblBacteria" id="ADW70420">
        <property type="protein sequence ID" value="ADW70420"/>
        <property type="gene ID" value="AciX9_3414"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3414"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_0"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="47705" checksum="690F2A24756EC456" modified="2011-04-05" version="1">MSTIKAVRGTRDLLPPETELWNRVEGVARKVFERYGFGEIRTPLFETTELFVRGVGEETDVVSKEMYTWEDRARAASEKAQSLTLRPENTAGVVRAYIEHKMDAAGGLRKLFYIGPQFRRERPQRGRYRQFWQIGAEVLGPVSSGAESAVRDAEVLEMLASLLDELGVKGWRLEVNSVGSSTDRPRYVAALRAALEPVKDQMCEDNRRRAETNPLRVLDSKAPEDQEIINGLPKIADYLDEASKEHFAQVLKALDACGVAYHVNPRLVRGLDYYTRTTFEFTVPDGSGLGTQNALLGGGRYDGLSEMLGGPKAPGIGFAIGEDRLILILQEQAAEQAESKMDAYIAPVGVEQNAAALALARELRRDGLRVEVGDGSFRLKKSFEAADKVAKAVVILGEDEVASGNLKVKRFATGEQRDVSRTELGAYLHGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E8</accession>
    <name>E8X3E8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581760.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3444"/>
    <dbReference type="EnsemblBacteria" id="ADW70449">
        <property type="protein sequence ID" value="ADW70449"/>
        <property type="gene ID" value="AciX9_3444"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3444"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_1_0_0"/>
    <dbReference type="OMA" id="EEMFYLF"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="44237" checksum="D7E7F8B3FD8D092D" modified="2011-04-05" version="1">MAETTRAETTRAATPRFDTIDLLRGLSILAVVLLHTWLRFWLNDIKVQPPVPPWLAHLLFHNGDYGVTVFFCISGFLITFTSLKRFGSLAQMKAAIFYRIRFARIAPLLMLLLAILSVFAVLHVPGFEINHKKASLLGAVFSALTFHLNWYEAVHGYLPACWDVLWSLSVEEMFYLFFPLACLLLLRWKHGMCVFIAMLTCFVVIGPFARAIWSAYNPIWQEKTYLGGTDAIALGCLTALLTNHLLGRRKVGDKTLLAIQTFGALLILFIALAPRWHWLHPAMRFLGRSALDNDVLMLGTCLVMLCSVLLGTGGSLFTAPIRWFGRHSYEVYLTHEFLVIGGVSLYLHYKKGPITLWYLGILLLTVPLGWLVSHFFFEPLNRKLRGARPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F7</accession>
    <name>E8X3F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3453</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581769.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3453"/>
    <dbReference type="EnsemblBacteria" id="ADW70458">
        <property type="protein sequence ID" value="ADW70458"/>
        <property type="gene ID" value="AciX9_3453"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3453"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_3_0_0"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="179"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="456" mass="51075" checksum="4355FC453A5D756A" modified="2011-04-05" version="1">MPRTETAARKIVQTLRSAGHQAFFAGGCVRDLLLGKTPKDFDVATSATPDQITALFPRTLQVGAHFGVILVQMDVEGEPTSTEVATFRHDGAYSDGRRPDAVRFSTDPREDVLRRDFTINGMLLDPFAEGSDNAILDFVGGRNDLAVKIIRTIGSPDTRFEEDKLRMLRAVRFAARLSFAIDPNTAAAITRHAAEIFQVSNERIRDELTLMLTEGNAHRAFELLYQTGLLHHILPEAERMIGVQQPPQYHPEGDVWVHTLLLLDHLFAGASPTLAWGMLLHDIGKPATFQPPNPAKPGDRIRFNGHVETGVRIAESILARLRFSNDDTAQILALIQNHMRFGDILHMKQSTLKRFLRLPHFEEHLALHRADCLSSHARLELYDFAKTQYESHDPEQIRPTLLLTGRDLIAAGYRPSPQFKSMLERAEDAQLEGILHSLEDAIHLIIKEFGAPPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W7</accession>
    <name>E8X3W7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3470"/>
    <dbReference type="EnsemblBacteria" id="ADW70475">
        <property type="protein sequence ID" value="ADW70475"/>
        <property type="gene ID" value="AciX9_3470"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3470"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_0_0_0"/>
    <dbReference type="OMA" id="GRPFVFP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="38856" checksum="1E2E4B6F00A2C5C2" modified="2011-04-05" version="1">MQTALIVGSTGIVGQNLAQRLLRNGWNVLGLSRGKQVVDGVQGLSADLRDAAAVREVLRGQDVSHVFLSAWIRHETEAENVKVNGGIVENVFDGLEGAKNLKHAALVTGTKQYLGPFESYGQTAAETPFREDTPRLPGLNFYYTQEDVLYAAAERMGFGWSVHRPHTIVGYAVGNAMNMGSTLAVYATLCRESGESFIFPGSHEQWNALTDVTDARLLAEHLEWASTRSAGRDEAFNVVNGDVFRWRWLWPQLAAYFGVKPEGPPAEIAPLEGRMGEAPEDWKAIASKYDLAESDVTRVASWWHTDGDLGRKIECVNDMSKSRRVGFVSHQDTPASFFDLFDRLKADQIIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y8</accession>
    <name>E8X3Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(Uracil-5)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3491</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581807.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3491"/>
    <dbReference type="EnsemblBacteria" id="ADW70496">
        <property type="protein sequence ID" value="ADW70496"/>
        <property type="gene ID" value="AciX9_3491"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3491"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_2_0"/>
    <dbReference type="OMA" id="SIIHVMN"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46980" checksum="C509E60398B13B12" modified="2011-04-05" version="1">MTTRITTPLYGGTFTPESGPNTSPDLPFVLPGELITPDPLTILEPSPHRVTPNCVHFTVCGGCHYQHADYPTQLTLKSQILQQILAPIGLQATPTVHSADPYAYRNRIRLRAEQIDGLTHFGYSRRNSNEFLPIRMCPIAAPLLWRAAETLTRLAESEPLITRWLARISELEFFISPNEERLQIQFFLRNAEDANQKGQNFAAFCDRLKAALPELAGASAQMDPELSRRTRRTWPGVTWGTAGLSYAVGERKYWVSRGAFFQVNRFLVETLVQIVTANRSGTLAWDLFAGVGLFARPLSETFQHVVAVEGAEAAAVALSNLSVQTPSLQAVHSPTFDFLRAAVLQRERPDLIVLDPPRAGLGTEGSALLARIAPPEIVYVSCDPVTLARDLAVLLPHYRATAVHLVDLFPQTFHIETVVTLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X400</accession>
    <name>E8X400_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ordered locus">AciX9_3503</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581819.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3503"/>
    <dbReference type="EnsemblBacteria" id="ADW70508">
        <property type="protein sequence ID" value="ADW70508"/>
        <property type="gene ID" value="AciX9_3503"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3503"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_0"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="54"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="433" mass="45335" checksum="EE6AE73EC321EB35" modified="2011-04-05" version="1">MSSVLISGGRVIDPANGLDALRDVLIRDGVIAGVESPGGFAGVEAQHLDAADCIVSPGFIDVHVHLREPGQTYKETIATGTAAAAAGGFTSVVAMPNTVPVNDTPESMAWMLDAARNPAIRLFAMPAVTEGSMGECLTDFAALAKAGAVGFTDDGKPVLHDAMMRAALLEAGRLGLVISQHAEDTRISPSSGINAGALAFRLGLRGMSVEAESSIVERDIRLLREIEKTDGVRAQLHVQHISTACALDAVRAAKAEGLHVTCEAAPHHFTLNENAIGNFCTNAKMNPPLRVEADRLAVIAGLLDGTVDCIATDHAPHARHEKEQEFERAPNGITGLETALGLALKVLHREHGASLTRIIELMSAAPAAIARLGNAGSLTSSKWGDVTVFDAGAEWTYSAAQTRSKSRNTPFDGVGMLGQVKATVVAGRIVFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X492</accession>
    <name>E8X492_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prevent-host-death family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578481.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0061"/>
    <dbReference type="EnsemblBacteria" id="ADW67152">
        <property type="protein sequence ID" value="ADW67152"/>
        <property type="gene ID" value="AciX9_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0061"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166037_3_0_0"/>
    <dbReference type="OMA" id="FHENSAE"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10608" checksum="CBCDE4D74ABA2871" modified="2011-04-05" version="1">MESLEETCSLATFHENSAEIIQQLKGTHRSVTLTVDGKPEVILQDVTEYQRLRDLAAAADIHEGIRQGLEESAAGKGRPASEFLDYMREKYGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A5</accession>
    <name>E8X4A5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1169</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579555.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1169"/>
    <dbReference type="EnsemblBacteria" id="ADW68232">
        <property type="protein sequence ID" value="ADW68232"/>
        <property type="gene ID" value="AciX9_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1169"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_0"/>
    <dbReference type="OMA" id="CINVLTY"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="467" mass="50525" checksum="A2B900BB5B7AFEAE" modified="2011-04-05" version="1">MSTKSTPLSRDGFTTEAPHSMQANARWFVCLLLFFATTINYMDRSVFSLIEPLLHKIPFMGWDFASDPHHQPLFDNNFGNVIICFQIAYGIGFLIAGRVIDRVGTKIGYALAIGIWALASFSNGFVGSVVGFCLARIILGLGESGNFPAAIKATTEWFPSEERALATGLFNSGSNVSAFIAPALVAFVTAKYGWRAAFFTTSSMGLIWLVVWLLFPYNKLRRGSTQTQANLEADFASQARGESATLPYSVLLRQRGFYAFALAKGLTDPIWWFYLFYLPQFLNRNYGLDLKHAYWEIVTVYAVSSVGSIAGGGLSGWRMKRGHSVNSGRKFALLVCALAVTPIIFVPQLGSMFPTNPWPAVLLIALAAAAHQGWSANLFSTPTDMFPSTAISTVVGIGGAVGAAGGATFTWIVKHFFSLHPLLIFGLAASAYLVSLAIFQLLVPVLGQPRRPSPPSNAGADPALTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C4</accession>
    <name>E8X4C4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1188</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579574.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1188"/>
    <dbReference type="EnsemblBacteria" id="ADW68251">
        <property type="protein sequence ID" value="ADW68251"/>
        <property type="gene ID" value="AciX9_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1188"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_81_0"/>
    <dbReference type="OMA" id="MREWFPM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="302"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="53208" checksum="E1F22A89954AB413" modified="2011-04-05" version="1">MNKQMETTVGTLSAETIAKLHRAPILESLTDETMHCLDGAHTLLLKPDDVLIRQGELKRVFWILLEGSLRVSQAGPKGHELTVHTHEAGAAFGEVFLLANIASTYSLRAVDECELLELDEEQFWALMMSCPLVRRAILGNMALRLQKMQGMIFQQEKMAALGTMAAGLMHELNNPGAAARRASSQLRENLTRMHRLTQKWSRTELTQEQKQCMFELQEYALSAKEKVALNSLEQSDAEEKLAEWMEENSVEDAWKMAPSLVAMGMHSEDLECARRSFAGETFPDALNWLEAMVSSMRLVGSIEESIGRVSDLVMAVKSYAYEGRGQTQTIDINKSIHATLVMLGHKLREKQLVIEKNMAPDLPILQTDCQGLNQIWTNLIDNAIDASFEHGTVKVKTWAEPGADGQTELCIRIEDNGSGIPLESQPKVFDPFYTTKAAGVGTGLGLGIVYKIVEQFGGKIWFSSTPGETVFLVRLPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J3</accession>
    <name>E8X4J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2366</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580719.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2366"/>
    <dbReference type="EnsemblBacteria" id="ADW69403">
        <property type="protein sequence ID" value="ADW69403"/>
        <property type="gene ID" value="AciX9_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2366"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_0"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="259" mass="28183" checksum="6ECD702311A11D5C" modified="2011-04-05" version="1">MKIRLDKLIVDRGHAASRERAQALILAGRVLVQDQRIDKPGTPVDDASILRMLGDDLKFVSRGGLKLERALDYWQIDVTGLACMDVGASTGGFTDCMLQRGAVSVLAVDTGYGQIAQKLRSDPRVSLRERCNARLLKPAELADQQAAANLSPITFFAMDVSFISATLVLPAVIGALSTESNPWQGTVVLLIKPQFEAGRENVGKGGIVREPAARQFAIDRVLTAARELKATNLEVIDSPIKGMEGNHEYLLRATFRTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K2</accession>
    <name>E8X4K2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-disulfide reductase</fullName>
            <ecNumber evidence="8">1.8.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2375</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580728.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2375"/>
    <dbReference type="EnsemblBacteria" id="ADW69412">
        <property type="protein sequence ID" value="ADW69412"/>
        <property type="gene ID" value="AciX9_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2375"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014657_1_0_0"/>
    <dbReference type="OMA" id="FNQIYGP"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02953">
        <property type="entry name" value="DsbDgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035671">
        <property type="entry name" value="DsbD_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233665" evidence="5">
        <location>
            <begin position="26"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="7">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="6">
        <location>
            <begin position="310"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="698" mass="73773" checksum="0D5F37918AE53FC5" modified="2011-04-05" version="1">MNLRRPRLALTALFVFLLASLSASAQIQEIGDGGPGPVKGQHITAEMVSLAPSVSPGGTVQVGLVLTMEEHWHVYWMNAGDSGQPPKVIWTLPSGITAGPMQFPIPQRLPLGPLMDFGYEDLVTFPMDISVASSAKPGPVHLDAKINWLVCREVCIPGKAHLGLTLNVAQNSPAGQPVGALGQALKLIPKPLPAGMSTAITAGRTDIILTLKGGSKETDAEFYPYDQDQILNAPDQDVVPTADGVSVRLKRAAELTALPLTIRGVLKFSDDEAYEIVAPVKAGEVAFAGTPAKNASAASGVTAIGAIGLAFLGGIILNLMPCVFPVLFLKGLALVQSSGEERKRLRSHGMVYTLGILVSFWVIVGVLLALRAGGSQAGWGFQLQSPVFIALLASGLFLFALSLAGQFDVGLSMTSVGGDLAKKQGYTGSFFTGVLATIVATPCTAPLMGAAIGFALAQPAGITFAVFTALGLGLAVPYLVLSFQPAWTRILPRPGAWMEVLKQLTAVPLFATVIWLAWVYGQLFSAQPGEAADHIARLLCCFLVLAIAGWALGRWPLNWRSTVAAVVLCVVAIAIPLTTPKPLVLKAVPYSQAALDEARAAGHPVFIDFTAAWCLSCQVNEKLVLHASDVESELTSHNFVVMRADWTAYDPEITKQLASINRSGVPTYVIYPAKGNADVLPELLTKSVVLDAIQRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q6</accession>
    <name>E8X4Q6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_3540</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581856.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3540"/>
    <dbReference type="EnsemblBacteria" id="ADW70545">
        <property type="protein sequence ID" value="ADW70545"/>
        <property type="gene ID" value="AciX9_3540"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3540"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="9"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="44508" checksum="AF77C2819F292D9D" modified="2011-04-05" version="1">MAEQVHRRVVVTGIGLICGVGKTAPEVWDGLLAGKSGMAPITAFDLTGHPVRFAAEVKEFDPLLFIEKKESRKMGRFIHFAIAAADEAMRHSGLVIDETNQDRFGVHIGSGIGGFDVIEREHTAMMNGGPRKISPFFIPATIVNLAAGHVSIRYKARGPNEATATACTSSAHSIGDAFRIIQRGDADAMIAGGTEAAITPMGVGGFAAMKALSTRNDDPEHACRPWDKNRDGFVVGEGAGILILEELEFAKARGAKILGEVIGYGMSADAFHMTGMAPEGEGCLRAMNAAMKVAGILPGQIDYVNAHATSTPLGDAMESKAIENVFGERALDHELLVSSTKSMTGHLLGGAGGLEAGITLMAMQHQIAPPTMNIEELDPMCRLNYVPNEPRAAKIDYALSNSFGFGGTNGSLVFKRWME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q9</accession>
    <name>E8X4Q9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor IF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3544</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3544"/>
    <dbReference type="EnsemblBacteria" id="ADW70548">
        <property type="protein sequence ID" value="ADW70548"/>
        <property type="gene ID" value="AciX9_3544"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3544"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_1_0"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="5">
        <location>
            <begin position="55"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="20987" checksum="18916B9847A67A03" modified="2011-04-05" version="1">MAPFEALKMAREKSLDLVEISPNAVPPVCKIQDYGKYLYEKDKSDRAARKKQKVIVIKEVKFSVTVDEHDYVTKKNMAVRFLHDGDKVKASLRFKGRQMAHRDLGYKIINRLILDIGDAGLVEFMPRMEGTTLHAILAPSKKAEQQQQAAPAAPKKAAPAPAAPAPVAATSAPETAPVADPVVASTDAVTVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S8</accession>
    <name>E8X4S8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3563"/>
    <dbReference type="EnsemblBacteria" id="ADW70567">
        <property type="protein sequence ID" value="ADW70567"/>
        <property type="gene ID" value="AciX9_3563"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3563"/>
    <dbReference type="eggNOG" id="ENOG502Z9FV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028737_0_0_0"/>
    <dbReference type="OMA" id="TRQFALY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233677" evidence="2">
        <location>
            <begin position="22"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="564" mass="59592" checksum="1AAB041D58AF20A7" modified="2011-04-05" version="1">MKRWFGLAFSGAALATGVGFAQTHVVKKPETVVRAVGVYEWTGELGKAKASRFVPVTVFIDNELQDAGFYLARPVPFALQTGTIFELDKAGVPDGTLELAYQRHLTGGVADLDGGWLGYGAYKAPPVMKASTKKSGALSKVEVSGGKSESSGPKFGKTPDASSKDPDRPTMRRKTDSDDTDTTKSASTSTPASTPTSPDDPNRPTMKRKTDSDTAASATPSSTASTPEDDPDRPTMKRKTDSDTASTPATSTPADDSDRPTMKRKSDSDSTTDSTDSKTSADSKTSTDSAGSGGENDPERPTLRKRTDAQRQGARKEHDSSSVTGVGSLNDDPDRPNLHRGKPAGRMNEDDLPPLQGTPADMQQLVAVSDAKNRDTHDFARAWADDAERTAVLGKMQAMARDRLTAYGDAAAKAAAAPAAAAKTAHAHAHAPVKRAAVKKPVVPASAAVALNDEVLKGFTLSYGGAATYFYTASTPGADGTTRYVTVVAQLEPAGDLKAALASVTDSTHLDRSPWMRLVDAVDVEASNRASLLLELRAQHSRQFALYRVIGAQAEQRFLTGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U1</accession>
    <name>E8X4U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3576</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581891.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3576"/>
    <dbReference type="EnsemblBacteria" id="ADW70580">
        <property type="protein sequence ID" value="ADW70580"/>
        <property type="gene ID" value="AciX9_3576"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3576"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_2_0"/>
    <dbReference type="OMA" id="CISRIEA"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="14332" checksum="7DC70F5AC2D446D2" modified="2011-04-05" version="1">MSSRSTRRYLNDILKSCDRIREYLDGVTLEDYLSASMRQDAVERQLQILTEAAFRLGDEAARLCPTVDWRSIRGLGNFLRHEYDKITPEIIWGKLHNDLPVLEEAVKVALLANPDPDPAHMEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X4</accession>
    <name>E8X4X4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0075</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578495.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0075"/>
    <dbReference type="EnsemblBacteria" id="ADW67166">
        <property type="protein sequence ID" value="ADW67166"/>
        <property type="gene ID" value="AciX9_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0075"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_1_0"/>
    <dbReference type="OMA" id="WAMMSIG"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="61764" checksum="391885C73F547F6E" modified="2011-04-05" version="1">MSAASSTIVNLPDQRTATLPKRNYLNNEHGLMSWLLTGDHKRIAMLYLISITFFFFIGGAFAGLIRLELLTPQPDLVASDTYNKFFTMHGIIMIFLFLVPSVPATLGNFLIPIMLGAKDLAFPKINLLSWYLYMAGGTFTLAALVLGGVDTGWTFTTPLSTHYLNTHVVTAATAIFIAGFSSIFTGLNFIVTIHRMRAPGMTWFRMPLFVWSNYAASILMVLGTPVLAIAIVLVALERLIGIGVFDPTKGGDPLLFQHLFWFYSHPAVYIMILPGMGVISEVISTFSRKRVFGYTAVAFSSVAIALFGFFVWAHHMFIMGVSNYSALVFSLLTMLVAVPSAIKIFNWAFTLQKGSITFETPMLYAFGFLGLFTIGGLTGVFLGSLGMDIHLTETYFIVAHFHFVMVGGMLMAFLAGIHFWWPKMTGRMYPESMSKLAAVTTFIGFNLTFLPQFILGYLGMPRRYHAYPPEFQVLNVLSTAGATVLGVGYLLPMLYLAWSLKYGAIAGNNPWQATGLEWQIQSPPLTENFIEVPIVEHEAYDYEWLANKTANEVTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X505</accession>
    <name>E8X505_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0119</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578525.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0119"/>
    <dbReference type="EnsemblBacteria" id="ADW67197">
        <property type="protein sequence ID" value="ADW67197"/>
        <property type="gene ID" value="AciX9_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0119"/>
    <dbReference type="eggNOG" id="ENOG5033JN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2035423_0_0_0"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="116" mass="13468" checksum="EC415251B995DC3F" modified="2011-04-05" version="1">MTKDAVEQVWNSYLEAYGSVAPETRERLLRESVSDDVVSTNPGEETQGFANLLAHVEQFQQRLPRAYFKIDKLFFHHEQVLTEWTLYKSDGTPLRSAYTYGVFDDQGRLKKLIGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X516</accession>
    <name>E8X516_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0131</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67208">
        <property type="protein sequence ID" value="ADW67208"/>
        <property type="gene ID" value="AciX9_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0131"/>
    <dbReference type="HOGENOM" id="CLU_1924616_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14270" checksum="6CDDE21D1AEE6117" modified="2011-04-05" version="1">MKTGSIRWLSVRMKMKMFSATVTSRHIYIERGNAGVLEHVLASASIPGTSAASASLASYVPAVTQPHFTADLDAIESWLLHAHAQCNGWHTGPQRHLHSSRDRSLNETGINLNGHLTEARAGDTLTDRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X564</accession>
    <name>E8X564_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1266</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579651.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1266"/>
    <dbReference type="EnsemblBacteria" id="ADW68328">
        <property type="protein sequence ID" value="ADW68328"/>
        <property type="gene ID" value="AciX9_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1266"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905929_0_0_0"/>
    <dbReference type="OMA" id="HTRSAVI"/>
    <dbReference type="OrthoDB" id="1251645at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="29321" checksum="2CCF047EA8DBD10B" modified="2011-04-05" version="1">MTSRRLPHLGHTLLFLLLAVIAFVASEAVILALFGRTHTLEALQNQRLQLAATTLTYLLTLLAARFIYPHIWSETFAQGIHWNLVKARAQAPKLIPLGLVLGFLLQAVESLITMPKSVPMEDYFKTPQMVWFLTFFGTLLAPAFEEILFRGLLLPALAIAIDYMKLPKTPDSLETWRTSTSFSPVALIISSIITSLLFAAIHAPQLGYTWAAVALLACVSLLLCAIRLYTDSTAASTLVHAFYNLSVFITLFVSTGGYRHLDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X584</accession>
    <name>E8X584_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1286</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1286"/>
    <dbReference type="EnsemblBacteria" id="ADW68348">
        <property type="protein sequence ID" value="ADW68348"/>
        <property type="gene ID" value="AciX9_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1286"/>
    <dbReference type="eggNOG" id="ENOG5031UU8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923668_0_0_0"/>
    <dbReference type="OMA" id="AFMDECL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="301" mass="33124" checksum="1F569DD17DC715D7" modified="2011-04-05" version="1">MLVVDVYGLGQTPAGGRPDALNALNESFVPTYQARAARLGETHPAYVEVAGDSLLLHLHGQQALKAQVLDERYQHLKDIAHVPFTIYLTLAGRKAGSLPEADLASMRGLLEKVNAAEGGLASAGFAEEEVPRQREILGASRRLLEGTLAGREMDVAAFAKAMGPLLMKNADEAGCEQVRTTHAQMMRWKALMSREEWETFAVVNKSPHQPRYRNVDTQYFGWLLGGDTTAWAYAGESSRVIYAETVFGPQDAGTELLSVLVDFEAGKAFFGDKWRLSEDVLSDGAERCVKGLDVRDRDWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X587</accession>
    <name>E8X587_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1289</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579674.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1289"/>
    <dbReference type="EnsemblBacteria" id="ADW68351">
        <property type="protein sequence ID" value="ADW68351"/>
        <property type="gene ID" value="AciX9_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1289"/>
    <dbReference type="eggNOG" id="ENOG5032RQS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179228_0_0_0"/>
    <dbReference type="OMA" id="TYLEVAC"/>
    <dbReference type="OrthoDB" id="1887666at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11375" checksum="D2D265F991E051C0" modified="2011-04-05" version="1">MGLSDQVFEVMCPECGTMMTIDPVTRSIVGHKAPPKKRMFEDFGEAAKAARDADARRDSIFAQSVEAQKNKDDVLAKKFAEAVKKAKESPLTERPLRDFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X599</accession>
    <name>E8X599_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1301</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68363">
        <property type="protein sequence ID" value="ADW68363"/>
        <property type="gene ID" value="AciX9_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1301"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504017_0_0_0"/>
    <dbReference type="OMA" id="WHDELFT"/>
    <dbReference type="OrthoDB" id="2051568at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="72"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="534" mass="59167" checksum="F674F0E0AECFCA7C" modified="2011-04-05" version="1">MRAGAALGAVSAFFERHAWLAAVLLVLVYLPAAFDASRHAPMWHDELFTYYIAQAPTLQQMWFDLRTLDLNPPLVYLLSRWSFALFGVNTLAVRLPEIAGFLVWMLCTFRFVQRRMGVMFGVFAAMLLLESDLFQFAVVARPYTLMLGFVALAMVGYQEATDGRRRLGLGLLLAGCVGMLLSHIFALLAMAGLILAELWSRRQRGKTDWAVLAALVTPLAVTAIYVPMLRNHGQAIFPAAFQPDGEAIFNFYIASVNRELVALALTALAVLVVLGVRHLRGGPQERGAAWFFTGAEWLTVIWMMTAPLLLILDLMASHGAFFPRYGAIATLGVVILTTALLGRWTISGGRLDERVGLLGAGIVLLMSGLWLVVPQQIAAGELIPTVANSEPRVKPCEACRITAAMDASLPLVDASGLTFMEMNHHENAQMLDRLYYLTDKAGSTQFAHANIFEQMQSVAERFHLRGHVAGYGDFVREHPRFFVLGRYDYPEDWLLRKLTADGAEIRVVARTSDSYRDTELYEVTVKPGRAHSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B1</accession>
    <name>E8X5B1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2235 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579698.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68375">
        <property type="protein sequence ID" value="ADW68375"/>
        <property type="gene ID" value="AciX9_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1313"/>
    <dbReference type="eggNOG" id="COG3673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_5_2_0"/>
    <dbReference type="OMA" id="VAYYHPG"/>
    <dbReference type="OrthoDB" id="348728at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="DUF2235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="DUF2235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2235" evidence="1">
        <location>
            <begin position="3"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="455" mass="50681" checksum="5F6BEABA689C6E85" modified="2011-04-05" version="1">MPKNIVVCCDGTGNEFGDSNSNVVKLYTCMKVDKEQVAYYHPGVGTMGNPNKTGVGKKMSLIYGMAFGAGFMDNLADAYRFLMAQYNDGDGPMDADRIYLFGFSRGAYTVRALAGAISMFGLLCPGNEGHLPYLLQMYSTESKAAYGRDNRHGRRLQETAESMAFRETFSRQVPIHFVGVWDTVSSVGWIYDPVKLLFDGQNPVMRKGRHAVSVDERRCFFQDNLWGQPLTPAETPVLAQCYADAADRQQDIVQAWFAGVHSDVGGSYSQSESAPAMDALRWMLDEAVADGLIQNDEKRTVIFGETDAALPGLSDLNKPALPGVCLHESLNWKWKPLEWFPHTYFDDKGDPQLQWSPWPHRREIPNDALIHPSLWKRLTTDANYQPPNLNQHDTVPYEASGTPLLHPEVRAKVQAEGFRVYRPGQVAKSNAVAQMSRAAAVLFGLGLTLLMRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J7</accession>
    <name>E8X5J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3621</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581935.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3621"/>
    <dbReference type="EnsemblBacteria" id="ADW70624">
        <property type="protein sequence ID" value="ADW70624"/>
        <property type="gene ID" value="AciX9_3621"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3621"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_2_2_0"/>
    <dbReference type="OMA" id="TSLEMPM"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="102"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="26442" checksum="AF8830404D6F6E70" modified="2011-04-05" version="1">MILAHIANAATSAHVTSSLAMLQEASNSFSLMDMWGHMSWIPRLIVMLLFIMSIWSLAVIIDRAIYFSAARSQSREFAPKVANALKTGNLDAAIKVADTTKKSHLAEVVTSGLQEFRSFGSGGAISEAQIESSKRALERSEAIVHSKLKRGLGGLATIGSTAPFIGLLGTVIGILNAFQQIATQKTSGIGAVAGGISEALVTTAFGLVVAIPAVMAFNYFTNKVEAFDVEMDNSSSELVDYFIKQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M1</accession>
    <name>E8X5M1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3645</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581959.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3645"/>
    <dbReference type="EnsemblBacteria" id="ADW70648">
        <property type="protein sequence ID" value="ADW70648"/>
        <property type="gene ID" value="AciX9_3645"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3645"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OMA" id="TETAACE"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26061" checksum="68226CB114C42D9A" modified="2011-04-05" version="1">MGKLEGKVAVITGGSSGLALASARRFVEEGAYVFITGRRQEQLDEAVKLIGRNVTGVRGDAANLDDLDRLFETVKREKGKIDILFASAGKGEAAVLGEITEEHFDREFGLIVRGTLFAAQKALPLINDGGSILMTGSVASVKGFPGFGVYAASKAALRSFARTWLNELKDRKIRVNVLSPGQVDTPDSQRLDEETRKMFESLIPRGKMGRTEEIAAAALFLASDEASYVNGIDFAVDGGFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M5</accession>
    <name>E8X5M5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3649</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3649"/>
    <dbReference type="EnsemblBacteria" id="ADW70652">
        <property type="protein sequence ID" value="ADW70652"/>
        <property type="gene ID" value="AciX9_3649"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3649"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056689_1_0_0"/>
    <dbReference type="OMA" id="KPPRINH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="403" mass="41797" checksum="762C1AECFA6A830D" modified="2011-04-05" version="1">MQRRARNETDKVNRLLMGYTVCGSDHFFLSRGVYAAEIVYIQRQVVTVIRVTFICTLEQRRTTVSKLEEISKRALSRRSFLAGTATAAAALTIGCNDATPVTTTPVTPTAPTAPTYTDVDILNFALNLEYLEAEFYLHAATGSGIPAADAGSGAGTVTGGAQITGLTAQQQQYVNSIAQDEYNHVKFLRSALGSAAVSRPAIDLTNSFNALAKAATVGLATPLTTFNPFANFNSFLIGGFIFEDVGVTAYHGAAGAISKTYLAPAASILAVEAYHAAILRTLIVGTSLPTTAAPQGDQTYVNIANAIATFRAAVSGGTSVSAGSETLLSSGLTFSSSTATTPTVGASSIVAADANAVAYARTFDQVLHIVYGTAATTTGTAYGVASGAFFPSGLNGNIKQTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P3</accession>
    <name>E8X5P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Organic solvent tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3669</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581979.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3669"/>
    <dbReference type="EnsemblBacteria" id="ADW70670">
        <property type="protein sequence ID" value="ADW70670"/>
        <property type="gene ID" value="AciX9_3669"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3669"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334875_0_0_0"/>
    <dbReference type="OMA" id="YNWNCCG"/>
    <dbReference type="OrthoDB" id="100018at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01411">
        <property type="entry name" value="LPS_assembly_LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020889">
        <property type="entry name" value="LipoPS_assembly_LptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LptD" evidence="2">
        <location>
            <begin position="334"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="852" mass="93512" checksum="95B60B50108C0F53" modified="2011-04-05" version="1">MAFALSGMHLHAQQMTTQAPPPPDQITAQTTGLPNTPSEVRYPLAYIVPAADGGSDVTWDAGTQSEHNGVYSLDNDVVITMKDRIIRADHIDFDKKTGDVIASGHLVITGGENQERISAAHGVYNLKNQTGRFYDVSGSVAMKPPAVRAPTLIPSDPTYSTASRVIYTSGNPFLFSGRMVVKTGPANYDIYDGTVTSCQLPKPDWLLSSTHFSMDGDKAKATGSTFHLLGLPVLYLPYVTHPVDSNQRQSGFLIPTIGQSSTKGFIIGEQIYVVINRSSDLTVGADYYSSRGYAQMATFRYRGQGQDFVNVHYTGLLDKLVGAANQGGEDFVLAGRHDFTKYTRTAGNIEYLSSYIYREAFTDNFNQAVTSDVVSTAYLTHDHDGFELAALADRYQGIKLIAQGTTPQQQVRLFHVPTFSFSATDHHLGTSSLEYTFDASASGLKRTQPNFATGGVVERFDFHPQVAVPFSIGQWRIRPAVGTRETLYSRSRVTPYTPGGTPVEDLGGLTRVTLEGELDIRPPVIERTFTPTAFKKFLGSQIRHTIEPEFAYRYTGGVDNFLKVLRFDETDVVSDRNEAEYGVTQRLFRKAAPHKDGTPCHTNELPQGPGLEPEAASEPVPEDQANKGCGNEELISWRLTQKYFFDPTFGHAVLNGRRNIFDSTLDLSGVAFLTEPRSISPLISRLRVRTTAKTDVEWDFDYDTGAKKFTSNNVFLDVHQGNAFGALSYARLDAPGRFYTSNVSSTVSSFNQMRVLLGYGQPTRPGLAIAGNAGFDLCPAVTSPTTATPSASCATLQYAAIQTSYNWNCCGLAVEYRKYELGAVRNEGVYRFNFTLANIGAAGNLRRAERLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U7</accession>
    <name>E8X5U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4036</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572743.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70831">
        <property type="protein sequence ID" value="ADW70831"/>
        <property type="gene ID" value="AciX9_4036"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4036"/>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_0"/>
    <dbReference type="OMA" id="QRMEIIK"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16766" checksum="B30E566A01772699" modified="2011-04-05" version="1">MQTFQTEETRPFRELCADHGLTVTHQRQVLYEVMQTMPGHPSPEEVYARVKRRIPAISLATVYKNIHLFVERGVLKEVSMHHGSLRVELNSHLHHHMVCSHCKAITDLDEKDLGELPALQSLPGGFQAERYAIDVIGICAACQKAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V0</accession>
    <name>E8X5V0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase, MGT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4039</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572746.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70834">
        <property type="protein sequence ID" value="ADW70834"/>
        <property type="gene ID" value="AciX9_4039"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4039"/>
    <dbReference type="HOGENOM" id="CLU_000537_7_1_0"/>
    <dbReference type="OMA" id="DQPMVAQ"/>
    <dbReference type="OrthoDB" id="1485440at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDPGT" evidence="3">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46537" checksum="879AD12B5544DDF4" modified="2011-04-05" version="1">MARFGAFCFPGTGHLYPMTALARSLQLRGHEVVIFGIADTEATVRAAGIEFCQIGAEDYPPGTLKMLDEHLARLKGIAAFRFTLARIRNSTRMILRDGPQAVRLANVETLLVDEAEFAGNVADHLGLSWISIALLPPLLPDDRFPPFWFGWSAGQDRLSRFRNRLAIRFLLRIASPIFNEVNQQRIEWGLKPLTNPEDGLSPIAQITQLPQALEFEISGKNPVGLYYTGPFLHAQQRPPVDFPWERLDGRPIIYASMGTLQNGSESIFKTITDACAGLDAQLVISLGGGLDPARLGKLAGDPLVVRFVPQLEILKRASLVITHAGINTVLESLSEGVPMVAIPLANDQPGVAARLRARGACVVVSRHTLNLARLRKAVLLVLEDGKYREAAQVLQKTIQTLNGPDRAADLIEQVLHIRPTQLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X3</accession>
    <name>E8X5X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4074</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70857">
        <property type="protein sequence ID" value="ADW70857"/>
        <property type="gene ID" value="AciX9_4074"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4074"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="FRAGFAI"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1315" mass="137923" checksum="27421ABE5C46A6B3" modified="2011-04-05" version="1">MRFFETGKTGPILGLTRDGGCGWKTGLAALTMPMLLTLGSAAGMAQTGGQGALEGSVLDQTGAVVPKAMVTATNQASGVSASATSSGAGLYSITPLIPGVYTVTVKAEGFQILSQKNIEVNGLTITGLNPKLNVGNTTETITVSEAPPVLQTTNPAIEAIITQDTYESLPIIMNNQQRDPTSLATLAPGAQGGARTPIFSGTGNYLAEVYVDGVPTTTTNQQGDNRIVSNGIPVESVEQLQIISAAPSAEYQGAGAIGFTIKSGTKQYHGQVVDFIRNTVFDTWGFAGNQQTYNTVVNGASVAVPTGKPVEHQNELSASIGGPIIGTHGKGFFFANYDQFHGRVGVTPTTFTIPTLLMRQGNFSELGTGNYIYNPLATVCSTTSSCQRPAFANNTIPTAYQSPISLYEQKFLPTPNVTGNGIVNNFQQGGVSGFDNHEYVFKLDYDLPHTQRLSYFYAHGVRQSAGYGAVLPLPYATAISSNISPTTMVLEHSIGINSRMVNQIKVGFTRFPGGSNSTTFNQHPYEAGPDVGITGLPAGQAAFSFPGSTFTATGLFTNAETPWSATGGSFSSTVQTPNAYTLIDNFQLNAGKHSMTFGVQYQRLEDNLTSQTSPSGIYYQTWNGVSTAQFIQAANGTYGNTLDNTKSGFAYASFLLGAVNTAATSVPLVAETGGRYAPVSPYFQDDWKIRPNLTINLGVRYDYLTPFHEVHDNYSFFNPNEINPATGNAGLLEYAGFRGSNISCECHTPIPTYLGNIGPRLGLEYSPDPNTVFRAGFAIVHSRGGGVGGRAGDSVGTGQTGFGSSIILPTANNVGATAGPSFYLNNSSVFQAAGLSNTNFGGPGYAIPPSVGPSVANLTVGTGNYVNASGAYVTPGGAPGYADPYLSSRAPTFNFWNLGLQKVLTKNLTLTVTYVGSQSHFVAGAGVSGFWSGQLDPRYIATLGGVLASDGKTNILAAQATPANIAIAQKADPSVTVPYAGYAQAGAVSSAATIGRMLRPYPQYTSPPSATYDNVANLSYNAFEVVLAQRQYKGMSFTVNYTYSHNIGDDGTTRSAFAIPSSVSSNGSPIAGNNRADRSLVITDTPQNLNMYGVLKSPFGKNGIGGDSLLVRALAGGWQLADIFTYNSGTPILIVGSGCTAPSQGNCMPDIVPGKENSIRANGGYGAPGVTYGNYNTTHYLDPNAFQALSTFGVGATPTTKIGDAPRSISSLRAPSKYNDDAAIQRSFNLSRERVKFIFRADCFDVSNKVTFSIPQTQTVSAVSNGANTGPGFASTVNNTGSISRTNAGNTAASFGEFTSFSGNRRFQFSGRVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z8</accession>
    <name>E8X5Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4102</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572794.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70882">
        <property type="protein sequence ID" value="ADW70882"/>
        <property type="gene ID" value="AciX9_4102"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4102"/>
    <dbReference type="HOGENOM" id="CLU_1004477_0_0_0"/>
    <dbReference type="OMA" id="WSAFSHE"/>
    <dbReference type="OrthoDB" id="1290891at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234430" evidence="1">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="28745" checksum="1CAAAB6A4A7D2BC7" modified="2011-04-05" version="1">MVPRSIVFIASFSFFPSLSASAQDLNLSPSRPTIANSATIQDAGVIQVEQGYDAYPRNPPGNLQTLATSIYYTPLPRLRLDFGWSNFDHIQQDVGAANGVGTITIGGKVELKKEDYHRPAPGIAVQYEAELPTASGTALQNYGQQAVFLINHHYGKDGNIDVMLNGSIVQANCQTQAGCSYGGQQSLALSFHTSKITRVYAEVFGQNNSESNTPPGTYLFGGFYHQFNDAFGIDGGLRFGVSNDSARIGTTVGLVFGKRVHGGSKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X620</accession>
    <name>E8X620_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar L-ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4124</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70904">
        <property type="protein sequence ID" value="ADW70904"/>
        <property type="gene ID" value="AciX9_4124"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4124"/>
    <dbReference type="HOGENOM" id="CLU_069313_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="231" mass="24462" checksum="A404E05740011ED3" modified="2011-04-05" version="1">MRRVLLFSLVLITAIPGYAGIKPVKKTAQELRADYLTRLHEQYMPPPDARTMGSLWAAANSLGDLSSDYRARNVNDTIVVQVSVQTTAAQSGNVNSSRAFNTASAITGLPGGVSTNATNPLFAANSATTLKGSGATASNTTFATSLTGQIIAVLANGNMVIEAERQISMNNQHEDLVIRGIVRPGDISSNNTIPSSSLSNLEIEMKGKGIISDSVRPPNALTRAVLWLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X628</accession>
    <name>E8X628_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flhA</name>
        <name evidence="8" type="ordered locus">AciX9_4132</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572824.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70912">
        <property type="protein sequence ID" value="ADW70912"/>
        <property type="gene ID" value="AciX9_4132"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4132"/>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_0"/>
    <dbReference type="OMA" id="MAINPGQ"/>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="711" mass="76316" checksum="2744A5DA99411BF0" modified="2011-04-05" version="1">MSQAMSPAINVSTIPSGKQSNGLLKMLSSSGEWVVPIAAVAMVFVMLVPLPSFLLDLMLTVSITASVLVLLTAVQILKPVEFSVFPSLLLLLTLLRLSLDLASTRRILLHGNEGASAAGKVIEAFGQFVVGGNYIVGFVLFLALIAIQYLVVSHGAVRTAEVTARFTLDAMPGKQMAIDADLNAGLITEQQARKRREGVSREAEFCGAMDGAARFSQRDSLATILIMAINIIAGFLIGVFQQGIPFQEALKTYTILTVGDGLVSILPSLLVSVAGGIVVTRAASKESLGVNVRKQILNSPRLLWIGGGVLGALGLIPGLPKLAFFPVAGAMMFAAYKMKVEKPFEELESVEVSSPTAAKVGTAASAAEAMDSVLKLDELMLEVGVGLVPLVDAKQGGQLLSRVKALRKSLAQQLGFLVPSIHITDNLSLREGEYVVHLRGVEIARWELRRGFLLAISSDTGVPNLPGEETREPAFDVPAKWISRELQAQAIAAGYAVVDSTSVLAAHLAELIKRNAYELLTRSETKRLIDRLNDSHPKLIEELVPKLMSLGEVQKVLQQLLREQVSIRDLGTILESMVDTATTNKNQVALVEAARQAMGRALIRPLLDPRGELRVVTLDSSIEEECARAANMQAGQLSSSALQINVARRVLDSLRATFGDSIGDAPPVLLCSSPGRFYLRRLLEPFIPKVVVISPSEIPPMTLVQSLGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H4</accession>
    <name>E8X6H4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572968.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71058">
        <property type="protein sequence ID" value="ADW71058"/>
        <property type="gene ID" value="AciX9_4290"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4290"/>
    <dbReference type="HOGENOM" id="CLU_131962_0_0_0"/>
    <dbReference type="OMA" id="GVPVWEH"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14339" checksum="E0FE04B00FA82657" modified="2011-04-05" version="1">MKTTVAAKSASGLIDQRIAELGDWRGAMLALVRRVIHEADPEVVEEWKWRGVPVWSHDGIICTGETYKKVVKLTFARGAALDDVAGLFNSSLDGNVRRALDIQEGETLDEAGLKGLVRAAVALNVGKKKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M6</accession>
    <name>E8X6M6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3898</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71176">
        <property type="protein sequence ID" value="ADW71176"/>
        <property type="gene ID" value="AciX9_3898"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3898"/>
    <dbReference type="HOGENOM" id="CLU_3396769_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="31" mass="3433" checksum="04EC3F556E52A093" modified="2011-04-05" version="1">MRAEGSPRWLKQRGEPGTLLVLIGDAINKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S2</accession>
    <name>E8X6S2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3946</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582240.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71222">
        <property type="protein sequence ID" value="ADW71222"/>
        <property type="gene ID" value="AciX9_3946"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3946"/>
    <dbReference type="HOGENOM" id="CLU_084703_0_0_0"/>
    <dbReference type="OMA" id="GAPIFCD"/>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="21537" checksum="F8338509B4D221C2" modified="2011-04-05" version="1">MTYIKDGAAIYKESFAIIRREADLSAFPPNLSRVVVRMIHACGQTDLPALVQASPDAARAGIDALAAGAPILCDAHMVANGVTRTRLPAQNEVLCTLRDPRTPDLAAQLQTTCSAAALELWRDHLAGSVVVIGNAPTALFHLLEMLAHGAPHPALIIGIPVGFVGAAESKQALADSTLNIPFLTVHGRRGGSAIAAAAVNALASEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T4</accession>
    <name>E8X6T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3958</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582252.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71234">
        <property type="protein sequence ID" value="ADW71234"/>
        <property type="gene ID" value="AciX9_3958"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3958"/>
    <dbReference type="HOGENOM" id="CLU_643662_0_0_0"/>
    <dbReference type="OrthoDB" id="404563at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="46165" checksum="2AC4B863E05FEC46" modified="2011-04-05" version="1">MIAFVSNLFKIGGRLRIPSTTRLTYALLDQGVVSFGNMVISAAVARHTPNAEFGVFILSLRSLDFINQICGVLIWGPYIFNMPGLSEERKKPYLGSVLTHQVVGCVLGVVTLLLLALLLNHHGEQYRQLFAPLALPSVAIVFREFTRRMYFAQMSFRAAFIADAITVAVQTTSVLLLLHSHRLHSTSAVWALSLACVPASLFWLFSNRRRFSFGISDCRDDLRLNMQLGRWFFGSNMTLLVGQQANPWILSAMRGPTAVAGYAVCEAVVNIPRVALTSMQNTMGPSMARAYAGGGKDSLRRVVRRHSTLIIGGTMVFVVGIVVAGPAIAKLIYHLTPPDAHVILILLACNLLAYGASLGTSYGLSAINQARLNFLAAVAGLVVQLALAYVLVNRTGATGAAAALLAGSIIVLLVQTGFYVREMRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X760</accession>
    <name>E8X760_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4342</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573013.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71294">
        <property type="protein sequence ID" value="ADW71294"/>
        <property type="gene ID" value="AciX9_4342"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4342"/>
    <dbReference type="HOGENOM" id="CLU_2000692_0_0_0"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_ligase_A_C" evidence="3">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="14193" checksum="8B60521E1B14EC76" modified="2011-04-05" version="1">MLWLTSNLGLDSIIIGFYRGKEPVYASRVRAGFVRATRRKVFEQIKHLTSPKYPFTKLPEAASGHWGQGLTTEKMKECVWLKLETVAQIEPLAWTGADHLRHIKFVGLRDDKDLGNLIRKLRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X774</accession>
    <name>E8X774_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4356</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573027.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71308">
        <property type="protein sequence ID" value="ADW71308"/>
        <property type="gene ID" value="AciX9_4356"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4356"/>
    <dbReference type="HOGENOM" id="CLU_2617047_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8648" checksum="8362D7079C22CF4B" modified="2011-04-05" version="1">MAEPVVLVVICETSEEAERTMAALHDVAIHAMTVSFVSEDSLNRSVRDHIFEAHHPLFEGRTSVARTNGDPGQQIENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H3</accession>
    <name>E8X7H3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4461</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573126.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71407">
        <property type="protein sequence ID" value="ADW71407"/>
        <property type="gene ID" value="AciX9_4461"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4461"/>
    <dbReference type="HOGENOM" id="CLU_118469_0_0_0"/>
    <dbReference type="OMA" id="LTHEFRH"/>
    <dbReference type="OrthoDB" id="1615239at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16423" checksum="A96B2418C1852129" modified="2011-04-05" version="1">MEFDLQAALPQLLPKAIAWAEAQARRVTETGEALSEAGTVTARRVGVEHPELIRILLVEELPLPDEPSLRGAAVFTGLIGPHMAGLTLGHSILIVKGALDLRLFSHECRHVHQYEQHGSISVFLPVYLQQIATVGYANAPLEQDARAYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J2</accession>
    <name>E8X7J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71426">
        <property type="protein sequence ID" value="ADW71426"/>
        <property type="gene ID" value="AciX9_4480"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4480"/>
    <dbReference type="HOGENOM" id="CLU_521542_0_0_0"/>
    <dbReference type="OMA" id="KWQENYE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="522" mass="55704" checksum="0E39C4C03EDC8898" modified="2011-04-05" version="1">MALKGSHMHARVNRREVTKWMLSASIGSLAAERLSASTASFNGANSSAEFRSIRHRIQQSISRGDATGVAIAVIEGGRIVWEEGFGWASREAALRATPHTPFSMASITKPFTTTTLMTLVAEGRFSLDKPANRSLLGSKIIGKNGDPNAATVRMLGAHVSGLPGMYESYDADEAKLVPSADVLLEEYGRLAYPPATCYEYSNIGYVALGAIASGLTQTELGPLMHRAVLSPLGLNDSFFGSDNVRVRDAATRYDPLGHAIPHCATSTPASGELYASAHDLAQFILFNMGHRVQSPATILSKIDIDELHRPVFVGQSGVASTFGWFTSHTASGVPFFFKIGGDPGVANRVFFVPSKGLACVVVTNQSNAGELAYSVCDEVMKSKLPEWRRPIEDCGSRSVPFIGGPSYRGRWVGALEDGGANMPIVLDIASGQSATLAIGSNRAEEITEMRTEGEAFTGTCSGRINSPDAIRARAKTLKLKLLLSGDSLVGRVFAVAGDPNFKNASLPYVLNLSRSRASDERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K6</accession>
    <name>E8X7K6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4495"/>
    <dbReference type="EnsemblBacteria" id="ADW71440">
        <property type="protein sequence ID" value="ADW71440"/>
        <property type="gene ID" value="AciX9_4495"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4495"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OMA" id="INAVGNP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="29623" checksum="FB68600A22A87093" modified="2011-04-05" version="1">MSTYPPNQDPSSTTTERLQTRRSKPAVNQVPRKILVLGATSGIAEATCRIWAQQGASLFLVGRNQQKLDAVAADLKTRGASYVDTAVADLDDTSSHPALLAHAINSLTGMDIAYLAHGVLGDQAAAEQNFKTAAQILHTNLISAVSLLTWLANFCVQRHAGTLAVLSSVAGDRGRKSNYVYGASKAGLSAYVAGLRNRVDREGVHVITIKPGPTKTAMTASMPGSEKFADVNKVAATIVKAIDNRTDNLYVPFQWQPIMFIIRHIPERVFKTLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N0</accession>
    <name>E8X7N0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4523</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4523"/>
    <dbReference type="EnsemblBacteria" id="ADW71464">
        <property type="protein sequence ID" value="ADW71464"/>
        <property type="gene ID" value="AciX9_4523"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4523"/>
    <dbReference type="HOGENOM" id="CLU_3168642_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="4833" checksum="B4675BCFDD1BD880" modified="2011-04-05" version="1">MSWFTDNCGTTFTPSNGSAPTAPMTVTTNTNGVLGTGTWTGSVVVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q1</accession>
    <name>E8X7Q1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573204.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71485">
        <property type="protein sequence ID" value="ADW71485"/>
        <property type="gene ID" value="AciX9_4550"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4550"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_5_6_0"/>
    <dbReference type="OMA" id="QGSASWW"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21451" checksum="ED8AF20E4663D1C3" modified="2011-04-05" version="1">MHVAVASFKGGVGKTTTAIHIAAYLQTLGPTLLLDGDGTRNATEWATRGEGLPYRIADVRSAVKLARDFEHTVIDTGQRPSDADLKALADGCDLLIIPAVPATMDSDGLRQTIEALVEMKADNYRVLITKAPPPPQAEANNLRNALEKAGIPTFSATIPLLKAFEKAAAAGIIVSAVDDPRAARAWEAYVSTGKEVVAYGNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W0</accession>
    <name>E8X7W0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4614</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71544">
        <property type="protein sequence ID" value="ADW71544"/>
        <property type="gene ID" value="AciX9_4614"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4614"/>
    <dbReference type="HOGENOM" id="CLU_3168643_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5147" checksum="54486EBEC81B3529" modified="2011-04-05" version="1">MTLIADSFKNGIPTATVVRVTNADHYIFLSNEAEVLHALNSFLSNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y9</accession>
    <name>E8X7Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4643</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71573">
        <property type="protein sequence ID" value="ADW71573"/>
        <property type="gene ID" value="AciX9_4643"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4643"/>
    <dbReference type="HOGENOM" id="CLU_1330379_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="23169" checksum="A378FD604F77DC33" modified="2011-04-05" version="1">MPRPISWLPRLHEITKTITHSVRSHHDRRDIEKLFELQPRAAQELLKLLPSVQVGTSRLLDRQVLADFLSVCGIPRTRQSSSIRYEGRSRQFPSGASGRWSGATSTRYHSLPFPIQSHSAAGGCRLTSARWSNSPRACSCWRAYSRARASNSPWSSSARRTGESGRFTERKSCVGLSRPCTVKSRSTYLGCWTFAYASIQPPECSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA3</accession>
    <name>E8WVA3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0204</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578606.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0204"/>
    <dbReference type="EnsemblBacteria" id="ADW67278">
        <property type="protein sequence ID" value="ADW67278"/>
        <property type="gene ID" value="AciX9_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0204"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_0"/>
    <dbReference type="OMA" id="LDIIWRM"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="510" mass="52408" checksum="0BA93F5DC7B4F508" modified="2011-04-05" version="1">MSEAAKSLQGGAAETGAGMTGVWVLAATILGTSMAFIDGTVVNVALPALQKSFQANASDVQWVVEAYALLLASLLLVGGALGDLYGRRRIYAGGVVLFAGGSVWCGLAGSIHALIVARAVQGVGAALLVPGSLALISASFPAEERGRAIGTWSGFTAITAAIGPLLGGALVQYASWRWVFLINIPIAVVVIAITVLKVPESLHEGMSHDLDWPGALLATVGLGAVTYALIEAQNVGNHSWLVGGLGVACLVAFVVVEAYSHAPMVSLRLFRSRDFSGANLLTFFLYGAFGGVLYFLPLNLIQVQHYKPTEAGGAMLPLIVVISLLSRWSGGLLERFGARVPLTIGPLVAGVGFALFVRPGIGGSYWTNFFPAVMVLGLGLAISVAPLTTAVMNAVPPSESGVASGVNNAVSRIAGLLAVAAFGLVLSAGFNAELSRRLDGLAISAAARQGVDEQRSKLGAAQSSDAGVEYAIAEAFVFGYRRVVWIAVVLAVASALSAAVLIEPKGGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB9</accession>
    <name>E8WVB9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578622.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0220"/>
    <dbReference type="EnsemblBacteria" id="ADW67294">
        <property type="protein sequence ID" value="ADW67294"/>
        <property type="gene ID" value="AciX9_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0220"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="EPIKVFN"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="35083" checksum="AC86454DB1E40B3B" modified="2011-04-05" version="1">MASYLITGIAGFIGSHLAHALVRRGDSVRGLDNLSTGSLANLSDIIPGIDFRQADLRDAAAVEEACQGIDYILHQGALPSVPRSVKDPRTSHESNIDGTFNLLEGARAAGVKRVVYAASSSAYGNQPGFPRRETMVPQPIAPYPVQKLTGELYMRSYWQVYGLETVCLRYFNIFGPGQTPDSPYSGVMARFILQMMRGEQPVINGDGEQGRDFTYVDNAVEANLKALTAPAEKVAGRVFNVATGERHTLNETYSILAGLLGHEAPPQYGPERSGDIRDSLADISAAQEAFAYAPQVGFEEGLRRTVAWYVAQYGASLKMESVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE7</accession>
    <name>E8WVE7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1334</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579718.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1334"/>
    <dbReference type="EnsemblBacteria" id="ADW68395">
        <property type="protein sequence ID" value="ADW68395"/>
        <property type="gene ID" value="AciX9_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1334"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_0"/>
    <dbReference type="OMA" id="SYKARIM"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="23060" checksum="D9AD7FB85655FF64" modified="2011-04-05" version="1">MTLAPILRILVVDDHPLMRSGIAGEINGQPDMRVVAEASDGEEAIAAFKLHRPDVTLMDLRMPGIGGIEAIRRIRTDFPISRFVVLTSSAGDVQVMRAFQAGATGYLLKNLLRTELIDTIRVVHAGRRRMPPELAQQIAEYAMEDAVSPRELEVLQEVSRGKSNKIVAGDLNISEHTVKNHLKSILSKLDASDRTDAVVIAIRRGYIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF8</accession>
    <name>E8WVF8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1346</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579729.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1346"/>
    <dbReference type="EnsemblBacteria" id="ADW68406">
        <property type="protein sequence ID" value="ADW68406"/>
        <property type="gene ID" value="AciX9_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1346"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_0"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="34976" checksum="D54A576935F38FE1" modified="2011-04-05" version="1">MKQEIVLVTGAAGFLGSHLTDKLLAAGHSVIGVDNLATGNLANLAHLKHEPNFRLVEQDICVPFDVGHVDSVFNFASPASPDDYHRLGIETLLVGSAGTINTLEIARKYNAGYLHASTSECYGDPEVHPQVETYWGNVNPVGPRSVYDEAKRFSEAAVTAYHRYHNVNTHLVRIFNTYGPRLQANDGRVISNFMIQALRGNPLTIYGDGSQTRSFCFVSDLIEGIVRLSRSAEHTPVNIGNPVEWTIKECALEILAVTGADLPIVHRPLPQDDPTRRRPDITKAKALLGWEPKVSLNEGLKLSLDYFKACIDAAPVAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG2</accession>
    <name>E8WVG2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ordered locus">AciX9_1350</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579733.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1350"/>
    <dbReference type="EnsemblBacteria" id="ADW68410">
        <property type="protein sequence ID" value="ADW68410"/>
        <property type="gene ID" value="AciX9_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1350"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_0"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023283222" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023283223" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="201"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="42468" checksum="BED31880CC1EE3D2" modified="2011-04-05" version="1">MAISDKVQTGALPLGFVWGAVKAGIKASGNLDVAVAVAPKGANAAAMFTRNQVVAAPVIVGRRHLEATGGRVSALLVNAGNANCATGEAGIKACIETCRAAGETFQCIFDEVFPSSTGIIGVPLPAEKILAALPKVVTELGATPAHAEAFATAIMTTDTKMKVARAVVDVDGAEVRIFGVAKGAGMIHPQLVAADAPKHATMLVYLFTDLVAEAAELSALLGPSVERSFNSISIDGDTSTNDTVLLLASGGSGIKLDERVGEAFGNALKLVCGSLAHQIVDDGEGVGHVVTLEIRGAETEADAKTVAKSIAHSPLCKTAWSSADPNWGRLLAAAGYSGVKFDPANVNVWIGTQAVFENGGRAALFDKDAAHQIMLAREYTITLDLGMGSAGCTFLTCDLTEEYVRINADYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ1</accession>
    <name>E8WVQ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580895.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2550"/>
    <dbReference type="EnsemblBacteria" id="ADW69580">
        <property type="protein sequence ID" value="ADW69580"/>
        <property type="gene ID" value="AciX9_2550"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2550"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484645_0_0_0"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="568" mass="63275" checksum="159EBE30DBA39864" modified="2011-04-05" version="1">MQDSSAFQFLAIDQIHESTTNPRRTFDEAKLYELAESIKHNGLIQPITVRPNDQGFEIVAGARRYRASLLAEVFSVPTRIVEIDDAQALEWQLIENSQRVDVHPYEEAQGFQRLLDMPGYDVAALVEKSGKSASHIYARLSLLQLIPTIAEAFTAERITASHANLLARLPQDAQSAAYEQCWRKDWQDKEPHLLPAKHLSAWIQTNLYLSLADAPFDHEDTTLNPKAGACTTCPRRSGYNTALFADVVSDQCLDSSCYHVKVEAFLDREIAAHPGLLQIENGWRNPKEQRPGAVQRGHIREIEAVTENPDAEPVTPCQSAKTAIVVYGKQLGRKLTVCTDKHCPVHDPQAAAEAAAHPVPAMAPAPEAETEEEAAERQAEFERQRAEYEEERQRREEERKQQFEREQAAIEAEHNRRAEIIKARQATFERIIENAPAILSAAQLRVLLRAIVNLDPYTFADDLAEDIAGDNENEQRSAEEVLISTIDTTADDKLTRFALRLALAGHVGIPREGEFDFLTEAEGVFAPPPQKKAGAKKAKQPTPIESPAKPAPKAKAQRANPNKKKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU8</accession>
    <name>E8WVU8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ordered locus">AciX9_3706</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582016.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3706"/>
    <dbReference type="EnsemblBacteria" id="ADW70707">
        <property type="protein sequence ID" value="ADW70707"/>
        <property type="gene ID" value="AciX9_3706"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3706"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_0"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="9594" checksum="70B0946EF4D1DAD5" modified="2011-04-05" version="1">MAHKKGLGSSKNGRDSNAQRLGVKKFGGEVVSGGSILVRQRGTPLKPGLNVGRGKDDTLFAKVSGVVRFQDRGQKGRFVSIDAAEIMSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF6</accession>
    <name>E8WWF6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="11" type="ordered locus">AciX9_2595</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580935.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2595"/>
    <dbReference type="EnsemblBacteria" id="ADW69620">
        <property type="protein sequence ID" value="ADW69620"/>
        <property type="gene ID" value="AciX9_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2595"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_0"/>
    <dbReference type="OMA" id="CGHTEPF"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="341"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="875" mass="95721" checksum="11B477ABE82668F1" modified="2011-04-05" version="1">MSQFCDVALPVPLDRTFIYSVGPVVPCVGARVLVPFGGQRLMGVVVRVHDAPPGDGVEVKPVQSVMDDDALLGEEMMRLAAWVAEYYCAPLGEVLRGMLPLSAEVKRQWTYRIGEAGRRVLYEGAAKGSSRRSRLTPEEQNREYAVLNYLENGEPAKAGALRSATGANRGLLEGMVKKKWLVREALAEERDARRVVRVAVLVELGMIVGSIGSGKAGFADAHPNRDETAMRMGHTNLEEVPASEELPAGTGRLPKLNENQLAIMAELAAVGGRLGVAELKARLIRAGVPGSSLVTLVKRGLVAIEEEAEGFHMGSGGGKKGAHEHLLNEEQMEAVGTIAAAMEKGGFRPHLLYGVTGSGKTAVYFAAMRRALAAGRSSLLLVPEIGLTPAMAGQMFAAFGEEVALLHSGLTPDERAEQWHRIRRGEARIVVGTRSAVFAPVRELGLVIVDEEHDSSYKQEESPRYHGRDVAVMRAKLSDAVVVLGSATPSLESWANAERGRYALIEVTKRVANRPLPVVELVDMRAEFREAGKEDIFSRRLVEETRAALDRGEQVILLLNRRGYSSVVMCRSCGEKVECENCALSMTYHRPAADSPDGIAQPGQRLECHFCGFRRRVPENCPKCQSEHLYFMGAGSQQGEEKLQELFPEARIGRMDRDTVRGRGDMERLLNRLHAGEINLLVGTQMIAKGHDIHGVTLVGVIGADYALGMPDFRAAERVFQLLTQVSGRAGRGDLPGKVLVQTYHTDHYAVKFAAKHDYVGFVGKEMQFRRSLQYPPFAVLANVVLVSEKLEEAAAWSAEIGRWFKQARPVGVKVLGPAAAPIVRLKRIYRFHFVLKAERRRALGDALRGMLEFAAEAGVPRRSLIVDVDAISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL3</accession>
    <name>E8WWL3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582066.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3758"/>
    <dbReference type="EnsemblBacteria" id="ADW70758">
        <property type="protein sequence ID" value="ADW70758"/>
        <property type="gene ID" value="AciX9_3758"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3758"/>
    <dbReference type="HOGENOM" id="CLU_2682636_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="74" mass="8587" checksum="42031B6DEE647CF7" modified="2011-04-05" version="1">MFTLLFIVLPILLVIHVVRLFTRPFRYRSYRQPFGYGGYGNYGGYGRRRHGLGGSLFSILALVALDRIFTGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL9</accession>
    <name>E8WWL9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3764</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582072.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3764"/>
    <dbReference type="EnsemblBacteria" id="ADW70764">
        <property type="protein sequence ID" value="ADW70764"/>
        <property type="gene ID" value="AciX9_3764"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3764"/>
    <dbReference type="HOGENOM" id="CLU_1978402_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13593" checksum="A63A26500215A82F" modified="2011-04-05" version="1">MAKQILGTFQSRNAADSVKDAFIKDGFNAADLIVMANRETSDPPEDAKLEVGAEGEPGFEGFEEKLGKAVLQVFHKEETIEGDGFEGEGKGGALLGITLQNDDDEARVRALLERHFASDIEVAQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN2</accession>
    <name>E8WWN2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3777</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3777"/>
    <dbReference type="EnsemblBacteria" id="ADW70777">
        <property type="protein sequence ID" value="ADW70777"/>
        <property type="gene ID" value="AciX9_3777"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3777"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_3_0"/>
    <dbReference type="OMA" id="WVMRYTT"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="77"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26639" checksum="059C57E620DAC2F9" modified="2011-04-05" version="1">MSQPKPAIRWLTYLVLMPLIALATTIFGCISLVAGLWDKSGRQQHAIARAWAQVLLWISLSPVRLIGKENLLGLGTAMYAVNHLSYYDTPVLFAKLPFQFRILAKQSLWKIPFVGWYLNRSGQVPIDAKSGRSAIAGLLRGAKTLTAGLPLVLFPEGGRAEHGQMTPFQSGAAFMAIKAQVPLVPMALIGTYELLPIHTYHLTPRPLKLVIGTPIPTTGLTTRDADALTAQTFAAITALYQQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR1</accession>
    <name>E8WWR1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0317</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578717.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0317"/>
    <dbReference type="EnsemblBacteria" id="ADW67389">
        <property type="protein sequence ID" value="ADW67389"/>
        <property type="gene ID" value="AciX9_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0317"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029423_2_0_0"/>
    <dbReference type="OMA" id="CAINCGE"/>
    <dbReference type="OrthoDB" id="1213919at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="54133" checksum="24E6A9AB7EAA883D" modified="2011-04-05" version="1">MPSSNPNESILTPGRLPLCVDLDGTLVKSDTLVDSVLVLARQHPRALLSIPGWLVQGKASFKQHVTNAISLDVSALPYNKPLLEFLFHQHSQGRAIYLATAADRTLADRIAAHYQIFAGVLASDGSHNLAGENKYQAFLQQFGEQFSYIGNASPDLPILTRCLEPMVANPTSGLASGLQAARIAPTQTFMDRANPAKAWLRAIRLHQWAKNVLIFLPLLLAHAWSFAHFAGSIVAFVAFGLCASATYIVNDLLDLEADRRHHRKRRRPFAAGDLSAMSGCLVVLAFLAAAAALALFLPNLVALFGLSLPQPYRFANWLLLYAITTTAYSLKLKRVVLLDVIVLSGLYTVRIIAGSGATGIEVSKWLAGFSVFFFLSLAFVKRFAELESLRLRESAPTNGRGYLISDIEQLRSFGTASAYASVVVLTLYISDLDTALYHHPGRLWLLVPVLLLWLSRLWLQASRGELDEDPVVYAITDKRSLFLGLAVAAVVLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX2</accession>
    <name>E8WWX2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1480</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1480"/>
    <dbReference type="EnsemblBacteria" id="ADW68533">
        <property type="protein sequence ID" value="ADW68533"/>
        <property type="gene ID" value="AciX9_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1480"/>
    <dbReference type="HOGENOM" id="CLU_2916063_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6963" checksum="A56579BB8872155D" modified="2011-04-05" version="1">MGELRIVVHDLYQPLSALQCRLYLGRMDTDLESMGAAIEESLAECERIVDQVRLLQNKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX39</accession>
    <name>E8WX39_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580996.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2656"/>
    <dbReference type="EnsemblBacteria" id="ADW69681">
        <property type="protein sequence ID" value="ADW69681"/>
        <property type="gene ID" value="AciX9_2656"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2656"/>
    <dbReference type="eggNOG" id="COG2322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104065_0_0_0"/>
    <dbReference type="OMA" id="HRKIARW"/>
    <dbReference type="OrthoDB" id="1623896at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="185" mass="20849" checksum="5A06B1C5260E0C7D" modified="2011-04-05" version="1">MSTLSTPTLGIRTPFSAVAGIITISGAASAFLVWLVYYHHPTDVSGTHLRFLPALNAVFNTLCTIALIIGLRYIRRREIVQHRNSMFAAFFFSSLFLASYITNHALHGDAHFPGHGAVRFFYLWILLTPHILASVLALPMILITFFLSLTGRFELHRRLARYTFPIWLYVSVSGVLVYAMLAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX44</accession>
    <name>E8WX44_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2662</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581001.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2662"/>
    <dbReference type="EnsemblBacteria" id="ADW69686">
        <property type="protein sequence ID" value="ADW69686"/>
        <property type="gene ID" value="AciX9_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2662"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_2_0"/>
    <dbReference type="OMA" id="FSATQMF"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="279" mass="28373" checksum="B4F91C0EDE59D29C" modified="2011-04-05" version="1">MNAVEFSVLIGVASLLAGFLGSLTGLGGGVVIVPLLALGFKVDIHYAIGASLVSVIATSCGSAGSFLREGYSNIRIGMLLEVATTTGAIVGAFLAAGTPTKAIAIVFGLVLIASAVISLRKKKPHANDDVKDPIATALKLNGSYPLPAGGRQAYNVRRVPLGFSLMFGAGALSGLLGIGSGAVKVLAMDEAMLIPFKVSTTTSNFMIGVTAAASAGIYLSRGYIDPVIAFPVTLGVVAGSLIGARFLVRAKTSAIRIVFAVVICLLGLEMIYSGLTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA2</accession>
    <name>E8WXA2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2720</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581059.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2720"/>
    <dbReference type="EnsemblBacteria" id="ADW69744">
        <property type="protein sequence ID" value="ADW69744"/>
        <property type="gene ID" value="AciX9_2720"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2720"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530446_0_0_0"/>
    <dbReference type="OMA" id="KHIDNSR"/>
    <dbReference type="OrthoDB" id="1594770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00910">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19491" checksum="FDF6FBD8E7C0CBEF" modified="2011-04-05" version="1">MATMTVGIEAMGTRAARGRAQSVAERNAERFEAQRRARRGPTPEVFFTKHIDNSRIVKADDPERRREMRLFTVAMTVLFSLCMVYVYQHFSSIEVGYKIEAQKTQVAVLQEKNRDLRLNEAQLTQPGRIVTIAKQLGLDAPAPGQIIRNDGFTGQEVNAPAYAEVAVPASGVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB1</accession>
    <name>E8WXB1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0372</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578772.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0372"/>
    <dbReference type="EnsemblBacteria" id="ADW67444">
        <property type="protein sequence ID" value="ADW67444"/>
        <property type="gene ID" value="AciX9_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0372"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_0"/>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="OrthoDB" id="460405at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="46244" checksum="D55AAD4E142CDED2" modified="2011-04-05" version="1">MASTNTVSGLRAGGALQSRDFRLYQAARFMVILGAEAQSVAVAWQVYQLTHSALSLGYTGLALFLPGLFFVLPAGHVADRYDKRWVILGCYGAQIVCTFILLWIALHPVASIAPIYVVLFLMGMGRCFSGPAASAMVPMLVPKEDFVNAVTWGATVYQTANATGPMVGGLLFTATLGAAFGHWGGAPIVYLFTLVMLAGFMVLVGAIRVRAVTGEKKAFNANTMLAGMKYVLKTRLLLGSISLDLFAVLLGGAVALMPIFAHDVLHAGPQGLGLLRAMPSLGALAVSITLIFRPLKRNAGKTMLWCVAIFGAATILFGLSHTIWISMVALLLVGASDMVSVVIRSSVLQLATPPEMRGRVSAVNWLFIGASNEFGEFESGVTAHWFGAVRAVVLGGIGSLLVTGAAAVLFPALRNADQLTAESLRAAEVELAEAEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY9</accession>
    <name>E8WXY9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0456</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578856.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0456"/>
    <dbReference type="EnsemblBacteria" id="ADW67528">
        <property type="protein sequence ID" value="ADW67528"/>
        <property type="gene ID" value="AciX9_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0456"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_0"/>
    <dbReference type="OMA" id="CECHDSA"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="33675" checksum="446016A086F978D1" modified="2011-04-05" version="1">MELRHLRYFCAVAEYGTFREAGRHLHVSQSAISEQVADLEHEIGGALLERSQRSTRLTRQGEIFLEEAKKTLLAAERTVDLTRRSLLGQEGTLAIGFFLWGAGGFFTRIIRDYRKLHPNIKLSLMDMHAHDQMAAMESGQLDIGFTRPLVAPYDKLFRSEPLYNDPIVVVMPKEHPLAKGPVTIQDLAAERWVLCERPFIPALFDSIIALCTSHGFSPNIVNGSSTWSGVMTLVEAGEGIGLVPSGARYIRPPGLVFCELEPNITKVGLSLVWNPLNEGPVVKSFLKLVRENKERIRKSAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC5</accession>
    <name>E8WYC5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2808</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581146.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2808"/>
    <dbReference type="EnsemblBacteria" id="ADW69831">
        <property type="protein sequence ID" value="ADW69831"/>
        <property type="gene ID" value="AciX9_2808"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2808"/>
    <dbReference type="eggNOG" id="ENOG50332Z0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175277_0_0_0"/>
    <dbReference type="OMA" id="MSVWDFQ"/>
    <dbReference type="OrthoDB" id="1968538at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="120" mass="13215" checksum="EAFB61F80686DFFE" modified="2011-04-05" version="1">MSQSNPDQPNQPDQANAQTTIHISNTEAYRDGYANSVQVRMSVWDFQLVFGTMRQDSADAVTLQNFQGVYLSPQQAKALWNVLGNNLAQYEATFGQLTLEPQPPGKIQIIPIPQPGGPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD2</accession>
    <name>E8WYD2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2815</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581153.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2815"/>
    <dbReference type="EnsemblBacteria" id="ADW69838">
        <property type="protein sequence ID" value="ADW69838"/>
        <property type="gene ID" value="AciX9_2815"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2815"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_3_0"/>
    <dbReference type="OMA" id="MPRPLCY"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="25418" checksum="237A332BF6B8633A" modified="2011-04-05" version="1">MFATFKMLFVFSFFGSIAGVIGIPISFVLGNVRRLYKISMWIVRTGVRAAGIRVEVSGTEHVPAGQSCIFMCNHVSNLDPPVVLPAIPGQSSVLLKQELMKIPILGTAMRMAKFVPVERGAKRDAAAASVTAAGEALRSGLHILVFPEGTRAVDGRLSKFKKGPFFLAQQTGAPVIPVAVSGTQTMMRKGSAAITPGVAKVEMLTPIFPGEYGSREEMLRAVYEAIAEALPVGMKPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG2</accession>
    <name>E8WYG2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2845</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581183.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2845"/>
    <dbReference type="EnsemblBacteria" id="ADW69868">
        <property type="protein sequence ID" value="ADW69868"/>
        <property type="gene ID" value="AciX9_2845"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2845"/>
    <dbReference type="eggNOG" id="COG3678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936161_0_0_0"/>
    <dbReference type="OrthoDB" id="1881593at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025961">
        <property type="entry name" value="Metal_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13801">
        <property type="entry name" value="Metal_resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233490" evidence="2">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="32852" checksum="90F7FDF8F723EAD9" modified="2011-04-05" version="1">MRLPLYLAAATLLPFACAAAQTSTQPSGPMPDQIINQHALDQFKTELRDMKIPQIDTTKLVDQKALAQLQSQLRDVKIPQIDGSKLINQAALQALVERTTANLRSNPAILALQMEGPLDGPMFGGQMGGPGGQDMGHGGPEGFGGRHDGHEGRIVPPGMWWKNPELAQKLNITADQQKHMDSIILESRIQLVQMKASLEEQELRLEPLLNANPPDTTKAMAQIDHIADTRANLEKANAKMLLSIRGVLTAQQWTQLQAEQHHRMQFNHDRPERPERPERPERPEGRPQQPPTPPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT9</accession>
    <name>E8WYT9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="6" type="ordered locus">AciX9_1727</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580094.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1727"/>
    <dbReference type="EnsemblBacteria" id="ADW68775">
        <property type="protein sequence ID" value="ADW68775"/>
        <property type="gene ID" value="AciX9_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1727"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_3_2_0"/>
    <dbReference type="OMA" id="LFNCNTP"/>
    <dbReference type="OrthoDB" id="2019898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="19680" checksum="1DE6368B1AA0A4C2" modified="2011-04-05" version="1">MEVAGFLLAGGLSSRMGRDKALLELGGETLVARGVRTLGEVCVDVAICGRVELGPFGRVVVDEEAGRGPLGGIVAGLSQTAWEWNLFCPVDVPFVPRVAWERIVARAAEGGCVAVMARVNGEVQPLCAAYAKGSVGAMRAFLATGRGRVTAAAESSGVVAHVDFEEVEWFRNANTPEEFAELMDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY5</accession>
    <name>E8WYY5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2877</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581215.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2877"/>
    <dbReference type="EnsemblBacteria" id="ADW69900">
        <property type="protein sequence ID" value="ADW69900"/>
        <property type="gene ID" value="AciX9_2877"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2877"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="INTRGVH"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1041" mass="107944" checksum="B1D0A6AF5C0371B5" modified="2011-04-05" version="1">MPSPAPLQSENLGRSRHSSRILNAALIVLSSLSLVCPAAVLAQAPAASTQTAPAAGGVTVRGTIADPDAAVIPGATVTLTPAAGKAFTTTTGSDGSYALRGVPSGSYSLTVTMPGFATYVRQGVRVSSGQALALDAKLAIQNQQTEVTVTANPNAVSVDPDSNASSTIIKGADLDALSDDPDDLSAELTALAGPAAGPNGGQIYIDGFTGGQLPPKSSIREIRINQNPFSAQYDKVGYGRIEVFTKPGTDKFHGNLSVQGNDSVLNTSSPFLGTANKQPNYYTLFTVGSLTGPINKYSSFTLSGSHRSIQTNTLINPTGFFANSATSTTLCAPLDITCTNQGSYPQSSRAVPAPQSRSDISPRVDIALGEKNTLTARYQYETNTLNNQGLNSGLALPSTAYSSGNTENTIQISDTQLLSAKIVNETRFEYQRTTATENPLSTLPTLTVQGTFTGGGSAAGISNSTSTHIEIQNYTSVALAKNFIRFGGRLRTTSEVLTSTAGTNGIFTYNYLLDPCVYGDSTGAKPSGCVATTTPCLPANNTVNNGGYYSSYQCGLASQYNITKINNLNVGTRTTDVGLYVEDDWKPRPNLTVSYGMRLEAQNNIASGHDFAPRFAVSYGLPHKGGGTPTVLRGGYGIFYDRFALADTLTNIRLNGLNQTQLTYNSPGAACQPSTTTGTGATLGCTTGATTAGLTTVYTANPTLRSSYNLQTGIGVDQQLGRIGTVSVNYINTRGVHQFLSRAYVQPTAYDYQYDSGGIYKQNQLAFNARINTKRVSLFGYYVLGFANGNTNGADTFLTNVNATTTDYGRSSFNHRNQAFVGGSVTAPFKIALSPFITAQSGQPYNITTGTDVNKDSNFNDRPAFLPGADSASCSNANSFSTPSQGSVYTPIPINYCTGPAQFTFNLRIGRTFGFGPLTDKAAAAKAAAQNNGGPGGPGGPGGPGGGRPGGGGGRGGGGGGRGGPGGGGPGGGFGGASNTGHKYNLSLGAQAFNLFNVIPYGNPVGTLTSSRFGQFNTLAGGQSSAGTAVRRFFLQANLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ2</accession>
    <name>E8WYZ2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
            <ecNumber evidence="6">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2884</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EC" id="5.4.99.16" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2884"/>
    <dbReference type="EnsemblBacteria" id="ADW69907">
        <property type="protein sequence ID" value="ADW69907"/>
        <property type="gene ID" value="AciX9_2884"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2884"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007635_1_1_0"/>
    <dbReference type="OMA" id="QEDRFPI"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012811">
        <property type="entry name" value="TreS_maltokin_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02457">
        <property type="entry name" value="TreS_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1210" mass="134891" checksum="4155B05D7A67B3D0" modified="2011-04-05" version="1">MKKLGSASDPLWYKDAIIYEIHVRAFADSNNDGIGDFPGLMSKLDYLQDLGVTCLWLLPFFPSPLRDDGYDIANYVDVNPSYGTLNDFKLFIDAAHKRGMQVMIELVINHTSDQHPWFKAARLAPPGSPEREMYVWSETDLLYQGVRIIFTDTEKSNWTWDDQAKAFYWHRFFSHQPDLNFDNPRVMEEVLKAMRFWLDLGVDALRLDAIPYLIERDGTNCENVPETHVKIKEIRAALDVEYGNRLILAEANMWPADVRPYFGDGDECHMAFHFPLMPRIYMALRQEDRLPITDIMAQTPDIPESCQWGLFLRNHDELTLEMVTDDERDYMYLAYSADPRMRINVGIRRRLAPLVDNNRRRIELLNSLLLSFPGTPIMYYGDEIGMGDNIYLGDRNGVRTPMQWNSDRNAGFSKCDPARLYFPVVMDPIYGYQVVNVEAQLSDQSSLLHWTRNMIALRKLFQVFGRGTLEFLHPENRKVLAYLRDLKRDDGTHETVLCVANLSRFAQPVALDLTTYAGMMPVEMLGYVSFPQIGKTPYALTVAPYSFLWFELQPAPVEIEEPMDVTPGAREEGEQVALDLLTKGWAGLVSGPGATLLETALPGWLSRQRWFGAKTRTIQTVRIAEWVQIPAGAGEILPTSKLPAANTLGDALLFLDIVYADSSKDTYQLPISYTTGHAAEELRAAAPLSVIATLSTPTGSAMLHDASTREDLRQALLTMIGDEATLALGNAASAGREIATTLIAAHTGRPAHEIGAKDTEVQEIAGKIAQEHSIEVADVAPEFIGAMPGAENPSMTQVFGGAESASAANGAAGQLKAYKSSAFDAARGTAALPSRTGSAEQSNTNFLYDQTLLMKLFRRLQPGLNPDVEIGRFLTEVAHFPRIAPFLGELTMVDSQGETTTLAMLQGMVSNEGDGWQWTLEELARFYESVSACPIPANQGKLPRYGNEGVTPEDAKQHLGLYLEAAALLGRRTAEMHLALATATDNAAFAAEAFTSEDLALDAKRIDTQISQTLEALKHGMQALKDLTADDAATILSRRIELFSRAHAIAAGTPAGKRIRIHGDYHLGQILRAKNDFVILDFEGEPARTLEERRRKQSPLKDVAGMMRSFSYAAWSGLDQYALRHPDQARSFEPWARLWENSVATEFLRAYRQTMETDATLLPDAAQADSLLSAYLLEKALYELLYELNNRPTWVRIPLAGILALPKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ12</accession>
    <name>E8WZ12_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2904</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581242.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2904"/>
    <dbReference type="EnsemblBacteria" id="ADW69927">
        <property type="protein sequence ID" value="ADW69927"/>
        <property type="gene ID" value="AciX9_2904"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2904"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149981_4_0_0"/>
    <dbReference type="OMA" id="HGFNISV"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="10692" checksum="06DC4E0C1F4E524D" modified="2011-04-05" version="1">MPIGKLTIELSIPHAQSLKDRRQVVRSLKDKLRHAFNASVAEMNEGGTLWNQATLCVAVISSSTQSVAQHLESIDKAASRIASTLSAEIADSYAEILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ45</accession>
    <name>E8WZ45_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ordered locus">AciX9_2937</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581275.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2937"/>
    <dbReference type="EnsemblBacteria" id="ADW69960">
        <property type="protein sequence ID" value="ADW69960"/>
        <property type="gene ID" value="AciX9_2937"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2937"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_1_0"/>
    <dbReference type="OMA" id="IKLQYFR"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6807" checksum="A88CED9D225C0060" modified="2011-04-05" version="1">MANATIKLQYFRSMICAPTKQKLTIKGLGFTRLNQIVVREDTPSIHGMVKKVPHLVRIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ85</accession>
    <name>E8WZ85_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579015.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0616"/>
    <dbReference type="EnsemblBacteria" id="ADW67687">
        <property type="protein sequence ID" value="ADW67687"/>
        <property type="gene ID" value="AciX9_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0616"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037723_0_0_0"/>
    <dbReference type="OMA" id="NHAESGE"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230096" evidence="1">
        <location>
            <begin position="24"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="195"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="440" mass="48045" checksum="554686B8FC827230" modified="2011-04-05" version="1">MSRRHPHTVLATSLLFASAPLLAQSSYSFTCAPTKPGTPALTAATRYATPASSAGFDLVAAPVTFAKNSCSSDKPFFFSAAEPDGSYQVTLTLGSPTASVVTVRAESRRLFVDRMVIPAGASRQVVFNVHVRTAPIHSDKVSPDLPVPTVKLKPREIGALDWDDKLTLEFNGTNPSVRSIAIKPITNVPTVYLAGDSTVVDQDKEPWAAWGQMLPVFFGPGLTIANEAESGETIRSFVGERRLDKVLSTIRPGDYLMIQFAHNDQKQGTGYVPAETDYKTYLRRYISDARAHGAFPILVTSMNRRTFDAAGKITPSLGDYPQAMRDIAAEQKVPLIDLNAMSKTLWETMGETGTLKAFVHYPANTFPGQSEELKDDTHFNSYGAYELARAVVQSIRDQHLALAPYLIKNNPTFDPTHPDPVATFTMPQSPMVDTAKPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB2</accession>
    <name>E8WZB2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0643</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579042.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0643"/>
    <dbReference type="EnsemblBacteria" id="ADW67714">
        <property type="protein sequence ID" value="ADW67714"/>
        <property type="gene ID" value="AciX9_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0643"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_0"/>
    <dbReference type="OMA" id="YPGDGTQ"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="31207" checksum="6541CFDD011C779C" modified="2011-04-05" version="1">MRIFVTGSTGFIGTELVNELIAAGHQVRGLTRSDAGEEQLKAVGAEVLRGDFTDLDCLRGGAKGMDAVVHLAFNHDDMAKFMQSATDEIAAIEALGSVLEPGKLLVVTSGIGMTAGAPGQARKETDPPAESQAVPRRPEQAAQAVAAKGVHVAVVRLPQVHDTRKQGLVTWLVGIAREKRVSAYVGDGANRWAAASLMDVSRLYHLAVEKTGAGVTTYHAVGEEGVSLREIAEVLGKGLGLPVISIPAEKAAEHFGPFLGHVSAMDMPAVSEWTQKALGWKPTGVGLIEDLSNMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF6</accession>
    <name>E8WZF6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thrB</name>
        <name evidence="7" type="ordered locus">AciX9_1796</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580163.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1796"/>
    <dbReference type="EnsemblBacteria" id="ADW68844">
        <property type="protein sequence ID" value="ADW68844"/>
        <property type="gene ID" value="AciX9_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1796"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_0"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="287" mass="30205" checksum="0E27BB75B8FB01C2" modified="2011-04-05" version="1">MPAFHLKLPATSANLGPGFDALGLAMALYLTLEATPSEHFQIEATGRNPIQVADIERNLLLETYRDLAPQALPLHLKIHNEIPLGMGCGSSAAALLAGVHLASHFGNLNLTAQEILEEACRREGHPDNVAACHLGGLTASAMDKTGVTAATFGRTLDWRLLLALPTTSLATTEARALLPDTYSRADAVANIQATALLVSAFALNRPDLLHAGTQDRIHQPYRSAACPLLPLLLPLAGTPGIHSVTLSGAGPSVLLITDPAEPLQPILDAIRHAASDPALEIVETRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR3</accession>
    <name>E8WZR3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0653</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579052.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0653"/>
    <dbReference type="EnsemblBacteria" id="ADW67724">
        <property type="protein sequence ID" value="ADW67724"/>
        <property type="gene ID" value="AciX9_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0653"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501322_0_0_0"/>
    <dbReference type="OMA" id="EIGRFCT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="326"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="543" mass="58500" checksum="8705C3C6AC1631EE" modified="2011-04-05" version="1">MPKLMKEDDQADVRPQMISQGQIPAGARVGLGRTLCGVVMGLACLDLMGWALHIPLLTSVVPHYSTMKPNTAAGLGLVALACWMRQRLDGPGRAWRRMTAVGAAVLGAALSFGTLAEYAARRSFGLDDLILRVPADRFGDPAGRPSLGTAGCLALLSLAMLWMEWSPGLSVGCLLTAGGVAMSALVGFVFNAGPLFGVPWLRSVAVHTATGILLLCIAGLAARPEREPIHSLMQQTYREGRTRWLLVGVTLLPMLVALLPMLALRWGIVDTGFALAIVVVTLTAVQTLILWRDSVALGRAEMRKSQVERALIQSEKLAVVGRLSASIAHEVRNPLEAVNTLMYLIRDSETLEEARSFAMTAESELARMNQITSQTLSFYRENRNRKHCDPAGIVESALTLLSGKIAASEVTVERHYQEDAGEVNCQDGELRQVFINLISNALEATPAGGRLVVRTRASRDWARRGTGGVRVVVADSGCGMPDAVRVKVFEPFFTTKMETGNGLGLWVAKDLIEKLGGTIRVWSSTRVGASGTVFSVFLPFVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX7</accession>
    <name>E8WZX7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0718"/>
    <dbReference type="EnsemblBacteria" id="ADW67788">
        <property type="protein sequence ID" value="ADW67788"/>
        <property type="gene ID" value="AciX9_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0718"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_0_1_0"/>
    <dbReference type="OMA" id="PECTRVY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21572" checksum="66B02105465E434B" modified="2011-04-05" version="1">MATTEISDLTQIADHPVLNLLNTVPMVDGALVDSLQADADVLAWLSHAGFRSIAKPPAPRNSLLQAARHLREQIRTAIEDREAGNPINRSVLNRMLSQGSSHAQLIEHPDGTFTTERIWPGNTPQQLLAPVAEAAADLLAHGDFNLIRRCEDTSCVLWFYDRTKSHQRRWCSMASCGNRNKVAAFRKRQQSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY6</accession>
    <name>E8WZY6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASPIC/UnbV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1835</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580201.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1835"/>
    <dbReference type="EnsemblBacteria" id="ADW68882">
        <property type="protein sequence ID" value="ADW68882"/>
        <property type="gene ID" value="AciX9_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1835"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017657_0_0_0"/>
    <dbReference type="OMA" id="NDGWMDI"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230121" evidence="2">
        <location>
            <begin position="22"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="UnbV_ASPIC" evidence="3">
        <location>
            <begin position="508"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="589" mass="63383" checksum="13EED7C752F3A303" modified="2011-04-05" version="1">MKAGWLHVSCLLVGLQISAKAQTSVVPPVKAASPATASTSTAAVPGLFVDTASKLGVTFTGFAQHTPTKYLIETMGSGVATFDYDNDGLLDIFFVNGAAVLDPAPKGTVPSKTGPAEWNRLYHQRKDGSFEDVTEKAGLQGVGYGMGVAVGDYDNDGFEDLFVTGYGGNHLYHNNGNGTFTDVTEPSGTGGSTTPGQTWSTSAAWVDLDNDGLLDLVVLRYVKWDWEDVWCGEYRPGYRAFCHPDIFPAIAPLVYHNDGKGRFTEISAKTGLNLPGKGLGIALADFDRDGKIDIAIANDSMPEFLYHNKGNGQFEETGMLAEIAVDGDGRTYAGMGIDAQDYNNDGLPDLIITNLANQKYAMYRNNGDGSFTYDTYMSGLARMSHLHSGWGIHFFDYDNDGLKDFLVAQGHDLDTVELNYPQLHYKEPMMLAHNSGQGFVDVSKSSGAVFAETWVGRGLAVGDLDNDGRLDAVVSTNGGLAHILHNEIKTSNHWLILNLVGHTSNRDAIGAEIELTTSAGKQMVTVSTAGSYLSSNDKRAHFGLGPDTGAKTIRIRWPSGVVQVLEHIAGDQVLKIDEPARTPSHQTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ4</accession>
    <name>E8WZZ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580209.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1843"/>
    <dbReference type="EnsemblBacteria" id="ADW68890">
        <property type="protein sequence ID" value="ADW68890"/>
        <property type="gene ID" value="AciX9_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1843"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527618_0_0_0"/>
    <dbReference type="OMA" id="TAFRHEN"/>
    <dbReference type="OrthoDB" id="956205at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="516" mass="53894" checksum="F5E53E6C8AF6C328" modified="2011-04-05" version="1">MVVYPAAAQTSGLDSSAPAAFTAGGQVLNALNGTPIPRALVTLGGRHVLTDAFGHFEFLQFTDQQARLSVVKPGYTQSLDPTEALAGHTVTGITSSMNLTLYPDALITGVVTGSDGLPVARVPVTLYREDLNEATSRSLPAGFTQTDTHGAYRFEQQPGSYRVHLGYAPHVSEAGDAMLPIDFPEQTDSERPAIFFAGPGETRQVDLQPQTSAAYPVSFHVDTETAGAGLQVICTPSQGSAFTVFAQPSRTRGDYHLDLPSGSYQLHAILMDRDGQQEALGKVTVSGKSVDGLLLHLAAVPRIPVELIVDPGSSTGTQSQGTLSSAPSTPRLNQFNLRLQRVGARDQPGQGDIVLNSRADQPGQFQAASGSYRLRAQASGSWYIKAASYGSSDLLSGRLVVAAGADGETIRVVVSNLVGQLSGSLLADGKAVPGVVYLIAHEPGMTPVRSLRAGSGTYKTSLPPGTYTAIAFSQSFTGDLRDPTVVAKLSGAQNIDVTPAGAAALDLTIQPQAGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X085</accession>
    <name>E8X085_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phosphogluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3046</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581380.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3046"/>
    <dbReference type="EnsemblBacteria" id="ADW70066">
        <property type="protein sequence ID" value="ADW70066"/>
        <property type="gene ID" value="AciX9_3046"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3046"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_3_0_0"/>
    <dbReference type="OMA" id="NGPHAHM"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230126" evidence="2">
        <location>
            <begin position="22"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="43654" checksum="8679299C79CA74E7" modified="2011-04-05" version="1">MTISRRRFLAATTSVAAAAYACGLPGECTAQTNFFPKRHKPVPPAPSFVYFGTDTAKPGAQGIYLSRFDPATGKLTSPTVAAASFRPAFFALGLGHGKRVLHVCNEGDEHSSAISSLLIDPATGALHPLGKVLSGSMGPCYLSLDADGQSAYSASYSGSGVATYLVEPDGSLSQPVERLDFKDAKFGQHGPNADRQQASHPHSARLSPDNRFLIVNDLGNDSIVTFPVDVTTARLGAPHVNERRAGSGPRHIAFHPNGRWVYSVNELDNRIDQLLWSGMRGDHAHGVEPQALLTDAGHSISTVDPGFHGTNTAAEVEISASGSYLYVSNRGENSLVVFAIDQGNGMLKVLQRISCGGKTPRQFTFDPTGKWLLCGNQDSDSVTVFACNQGNGGLTGPVQTLTVPSPMMTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K4</accession>
    <name>E8X0K4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein AciX9_1909</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1909</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580274.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1909"/>
    <dbReference type="EnsemblBacteria" id="ADW68955">
        <property type="protein sequence ID" value="ADW68955"/>
        <property type="gene ID" value="AciX9_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1909"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_0"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="26509" checksum="AB75111FB13F5248" modified="2011-04-05" version="1">MSGHSKWATIKHKKGATDAKRGKIFTRLIKEITIAAKSGGGDPDGNPRLRGAIAAAKAENMPADNIKRAIQRGTGELEGVSYEEMSYEGYGPGGVAVIIDVLTDNKNRAVSEIRHAFSKNGGNLGTEGAVSWMFTKKGVISIAKDSANEDKLMEIVLESGAEDLNDEGEHWEILCDPADFEAVTNALKAAKIPTETAEVTKIASTYTKLEGSQATAMMRLLETIEDLDDTQNLYSNFDFDEAHVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L3</accession>
    <name>E8X0L3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1918</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580283.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1918"/>
    <dbReference type="EnsemblBacteria" id="ADW68964">
        <property type="protein sequence ID" value="ADW68964"/>
        <property type="gene ID" value="AciX9_1918"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1918"/>
    <dbReference type="eggNOG" id="ENOG5033ZVU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568692_0_0_0"/>
    <dbReference type="OMA" id="IRRDHAF"/>
    <dbReference type="OrthoDB" id="1957075at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011463">
        <property type="entry name" value="DUF1569"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07606">
        <property type="entry name" value="DUF1569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19791" checksum="8EA65E9D1978B6F0" modified="2011-04-05" version="1">MNDDLTTLVSAVNAALQGLERNQTQAAPVHRPEKWNIQQIVEHLLLTYRLTSASLEDRIRKGTPTRASRTLKHRIAQLVVVRIEHFPSGHKAPAPVTPPRLTSLRSGEELAGRVQAELTRLGQLCTQAAALFGDRRALSHGMLGPMSMQQWRHFHLVHGLHHIKQIQRIRRDHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T1</accession>
    <name>E8X0T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA-(Protein)-cysteine S-methyltransferase DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3095</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581429.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3095"/>
    <dbReference type="EnsemblBacteria" id="ADW70115">
        <property type="protein sequence ID" value="ADW70115"/>
        <property type="gene ID" value="AciX9_3095"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3095"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_0"/>
    <dbReference type="OMA" id="RIDMATH"/>
    <dbReference type="OrthoDB" id="1928537at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14830" checksum="31F8FFD69174A1D2" modified="2011-04-05" version="1">MAKGQVFDQFTVERVKRSLLRDSLRKNEQRDLAFRHMILSIPPGKVSTYGGVAAAAGYPRYHRSVAKLLRTGPADQLPWHRILGAGGEIKLRGAGADEQRARLELEGVAFKGARVDMERHEHTMRPWEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X1</accession>
    <name>E8X0X1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3143</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581468.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3143"/>
    <dbReference type="EnsemblBacteria" id="ADW70155">
        <property type="protein sequence ID" value="ADW70155"/>
        <property type="gene ID" value="AciX9_3143"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3143"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_2_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="12443" checksum="8AF4B15C5C799D87" modified="2011-04-05" version="1">MKNKLTLVVRFRIPESQKAEFFSKIREVFTHIVEENTFIEASLVQDMRDPESILNYEVWDETPDSFMKGQMTKSYRAAFEKMIVDLKIERTPAWYSTIDDWKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X106</accession>
    <name>E8X106_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpr_kinase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0804</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0804"/>
    <dbReference type="EnsemblBacteria" id="ADW67872">
        <property type="protein sequence ID" value="ADW67872"/>
        <property type="gene ID" value="AciX9_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0804"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073290_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpr_kinase_C" evidence="2">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="32557" checksum="BA0F310900D78DF1" modified="2011-04-05" version="1">MTPPYRAMAFGCTWQSDIPLPSFESDPGEAEPDILVSQSHGPPPDRGDSPSASRLRNLPGGSRFIVEGIATIDTYGGKRAEIYLGLNWSGVMPVEFFGSVSGLFMTWRGAIAMHGSAVEWNGHAILICGHSGAGKSTLAAALIARGARLISDDLSILHPRKANQPPLLYAGRRAMRLFPDIAQMLGDRVLCTEAPGSVDGKKLVVPPRIPATQAVPLGQVIVLDDEILQTQSTQEQEASQILEAHLYRPRAYAQIPGLFLRQAQIKSLARIVPVSTMQRQEARNARQFEMIAEVAENKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X145</accession>
    <name>E8X145_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579236.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67911">
        <property type="protein sequence ID" value="ADW67911"/>
        <property type="gene ID" value="AciX9_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0843"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_41_3_0"/>
    <dbReference type="OMA" id="RYSTWKG"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="18438" checksum="CCE2964C06E6887F" modified="2011-04-05" version="1">MPTVQIRPALPADVPLILHLVRELAIFEREPDAVKATEADLHRYGFGPEKQFDCLLAFIENEPAGLALYFFNYSTWTGKPGIHLEDLFVLPAFRKQGIGRALLSAVARIAVEKGLPRLQWDVLRWNEKAIAFYQAHGAHLKDDWGTMRVEAESLTALASQATPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X183</accession>
    <name>E8X183_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1991</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580356.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69037">
        <property type="protein sequence ID" value="ADW69037"/>
        <property type="gene ID" value="AciX9_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1991"/>
    <dbReference type="HOGENOM" id="CLU_1480063_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="20769" checksum="8307ED7AC43C1F46" modified="2011-04-05" version="1">MTPEGWQQSGIPVTEGDHITVTAGGKVCVDMHSIWENVERRLHYENEWVEKEKIRRDDPEETRVPKQFFTKEERASLILTRPWVGPNGFSLDSYKPSFRSRREHYLIPSEPAGGLVAGIGGKNVPSSGSLFFAGQHNDSIADKSGELWFTVNDVQFDDPTNRELFYDDNIGSFWVKVIVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A6</accession>
    <name>E8X1A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580378.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2015"/>
    <dbReference type="EnsemblBacteria" id="ADW69060">
        <property type="protein sequence ID" value="ADW69060"/>
        <property type="gene ID" value="AciX9_2015"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2015"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1319428_0_0_0"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="22646" checksum="4CDEA6C989A35A48" modified="2011-04-05" version="1">MQDKSLLGNAPAFVPIESDLLDGFLSSLPQHLLAPGEMLHQQDSLPPFVFLIRRGIVKMTYATEDGVESMIGLRSVGWLGGAAHVITGTLSTSTVHALTACCITRIDAELFKSVIQTDAQLAHKVMCSLARELVTTRELVKQVMANSAQSRLLTYLNESRSESQGWKCADIKSVLSQAEVAQLLGITPEHLSRIKHSEPKPRLLNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B9</accession>
    <name>E8X1B9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2028</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580390.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2028"/>
    <dbReference type="EnsemblBacteria" id="ADW69073">
        <property type="protein sequence ID" value="ADW69073"/>
        <property type="gene ID" value="AciX9_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2028"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_7_0"/>
    <dbReference type="OMA" id="WHTLRHT"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="70"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="39350" checksum="EBF5BCD7DBFDC50A" modified="2011-04-05" version="1">MATRKAPAKVRGVYEREPGSGVWWICYKQGTVRKREKVGRKGDAIELYRQRKTELRAGAKLAPNLRHKGVTFGVLAEEALAWSAEFHPKDIKTVMGRMKMLTGEFGLVAASDLTPQMIDSWLTDYRTKGKNVLAPATKNRYRALISLVYRQGMRNGKVKANPARLVAARAENNARVRYLLPDEEKALRTAMENGRLCYIPALDVALNSGMRLSEQFSLTWEAIDFGRKEIVLDETKNGSSRHIPMNSTCEAAFRSLVVAGQKPADRVFSSRHGKAINTPRKWFEASAEEAGITDLTWHSLRHTFCSRLAMAGVDIRTIAQLAGHKTLAMAMRYSHLSPSHNLSAIEKLVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E5</accession>
    <name>E8X1E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent carboxylate-amine ligase domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2054</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580416.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2054"/>
    <dbReference type="EnsemblBacteria" id="ADW69099">
        <property type="protein sequence ID" value="ADW69099"/>
        <property type="gene ID" value="AciX9_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2054"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_4_1_0"/>
    <dbReference type="OMA" id="VNMRPPG"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="124"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="45432" checksum="9006D4AD379BFD17" modified="2011-04-05" version="1">MSEWTSGTSGKPAIFCISTYVKGQAFLREAAALGCEVTLLTVDRLRDDDWPKDILHELLTMPEDLTPGQILNTVMYLARTRRIDRIVPLDEFDLEAAALLREHMRLPGLGETATRFFRDKLAMRTEAKKAGIAVPEFTGVFNYDDLRAFMRNVPGPWLLKPRTSASAIGIRRIEHEDQLWPALDELGDLQSHYVMERFVSGEVFHVEGVTWGGKVLFAQPFQYGKPPMQTMHQGGVFTTRTLELGSKDGKGLLKIHESLIAGLHMHAGVTHSEFIRADADGRFYFLETAARVGGAYIAETLEFATGVNPWVEWARIEVALAKGEEYKLPELRKEYAGSVISLAKQETPDTSGYTDPEIVLRLHKTHHAGIILKSGSEPRLKSLVESYAGRFLDDFCAVMAVPDKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L6</accession>
    <name>E8X1L6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3240</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581563.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3240"/>
    <dbReference type="EnsemblBacteria" id="ADW70251">
        <property type="protein sequence ID" value="ADW70251"/>
        <property type="gene ID" value="AciX9_3240"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3240"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078474_0_0_0"/>
    <dbReference type="OMA" id="AWMEMLK"/>
    <dbReference type="OrthoDB" id="1759718at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="308" mass="34427" checksum="E37A3BFD4EA3E730" modified="2011-04-05" version="1">MANMIQFDGFDGNKRSGTHCLACEEMLMDAVDGTLNAPDQTWFDRHIASCVTCSEMYADAQRGAAWLEMLKSPRPEPSTDLISRIMAQTSGNPVRVEADSVPEYSGDVWNTGATPFLVPTPIVLPVHTGNLLEFQPRSNNRSAFGRMLLEPRLAMTAAMAFFSIALTLNLMGVRLNELHTADLKPTNLKRSFYVTNAQAVRYFDSLRVVHVMESRVEDLRQQNEEREQMRRESPAAPQNDTQPEQKDEKKQEPGPGTSRREVPLSEKARYVMTNATVPNGKQRLGAFWTGVSASANDKNTDKRTGSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N0</accession>
    <name>E8X1N0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0881</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579273.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67949">
        <property type="protein sequence ID" value="ADW67949"/>
        <property type="gene ID" value="AciX9_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0881"/>
    <dbReference type="eggNOG" id="ENOG5033YW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672266_0_0_0"/>
    <dbReference type="OMA" id="ECIGRIR"/>
    <dbReference type="OrthoDB" id="1854909at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="409" mass="46093" checksum="F0CDEBB2AE1325CE" modified="2011-04-05" version="1">MHITRILRAGVLSGLAILLVAVAIVQIEQHLLRYRAERLLADFQSIRLHQSTWADAQTLMTRWGAWGHYDGQCTAFDCTYTIRLADPTSRIANYIKSDTRWWLLRQVVRAYEFVGGKPGWLTVSFVVQDGVIWRSTVGLLLDVPPHTEKDDEYGYSLMLLAKASDSLHQKKPHDPWVLGTDDQLADHPNYKEGRPSGCEVCLAVEVTFTPYISPAELKQVTSYDLSCFTNFRHCLNLPDVLPIARDWHLYPTTEPAYKVPSEPTIPRSCAIPIFVRSRDASSIMLVDAISSTITKPNPGEELLGHEYIQTTKVRLVQTLKGTSPFTIGEVFNAVSWPGDSSNYPSQEREQFEIGKRYVIFPKVVEPPSPVYADFCGLIESAPSVVAQVNQGLTQNDVLRRPELFGRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W8</accession>
    <name>E8X1W8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2085</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2085"/>
    <dbReference type="EnsemblBacteria" id="ADW69129">
        <property type="protein sequence ID" value="ADW69129"/>
        <property type="gene ID" value="AciX9_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2085"/>
    <dbReference type="eggNOG" id="ENOG502ZXC2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2633124_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="8106" checksum="6ED8CB2417C7C9B4" modified="2011-04-05" version="1">MIKLLEYGVVKPKVSCPHCNTVGNVRIKRTSQKAGVSGGKLAGAILTGGISILATGLSRKEIVNLAHCDNCTVSWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X201</accession>
    <name>E8X201_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2118</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580478.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2118"/>
    <dbReference type="EnsemblBacteria" id="ADW69162">
        <property type="protein sequence ID" value="ADW69162"/>
        <property type="gene ID" value="AciX9_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2118"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_2_0"/>
    <dbReference type="OMA" id="YPRFGEF"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="48248" checksum="DF0BA08806AC4FE2" modified="2011-04-05" version="1">MSVNYPWGIMSTDQTAASKTASRMNWGGNYAFQAATLHEPGTVDEVREIVARAAKVKALGSAHSFNSIADTDGTQVSLARLKSMELNVAEKTVTVGSGIIYAQLAPYLHERGFAVHNLASLPHISVVGACLTATHGSGSGNGCLSTAVSGFEFVAADGSLQTLSRAKDGELFAGAVVNLGGLGIITSVTLEVQPAFEVAQSVYEGLALSQLEKHLEEIFLSGYSVSLFTDWQEQRIRQVWVKRRVESGVPPVFAPELFGATLATKTLHPLPNGSTENRTVQLGIPGPSFERLPHFRPDLTPSNGEELQTEYFVPLDRGYEAIMAVEELRDRITPHLFISELRTVAADDLWMSMAYRRPSLALHFTWKRNWEGVREVLPLIEAKLAPFAARPHWAKLFTVPPAQVQQLYPRMYDFKALLAKYDPQGKFRNAFLDTNVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X212</accession>
    <name>E8X212_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2129</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2129"/>
    <dbReference type="EnsemblBacteria" id="ADW69173">
        <property type="protein sequence ID" value="ADW69173"/>
        <property type="gene ID" value="AciX9_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2129"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_4_1_0"/>
    <dbReference type="OMA" id="DECFAFG"/>
    <dbReference type="OrthoDB" id="1380748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="26201" checksum="DD6A2328CC9EFC23" modified="2011-04-05" version="1">MCIVAHPDDECFAFGGALALAAQQGIETYVICLTDGQAATNRGDSCSSEDLGRMRREEFAASCRVLGVSRYELLDYQDAQLEFADFSKAAGRLVAKVREYKPDVMVTFGLDGGLNTHPDHTMVASLTSAAFHWAGLEKRYKGLGPVHLAKRLYMLSTDFFMDGRPEPAPLPWTVKLDVRAAMEQRQEAFRQHASQAPLMERTRAMFEEHGAFEYYTLVAERGCAAATAGESLFAGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X215</accession>
    <name>E8X215_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3247</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70258">
        <property type="protein sequence ID" value="ADW70258"/>
        <property type="gene ID" value="AciX9_3247"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3247"/>
    <dbReference type="HOGENOM" id="CLU_1193456_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="26192" checksum="F1A496917E5E48CD" modified="2011-04-05" version="1">MFNYVVKDPNSSGLSRELWIKDQPGIKPQSVSSNLYCAFVSWSLSTDLGACLPESHTQGVQLNPFMTRSAVRDVYRELSKSINLSLSCQPFRFSLRFTEEAQDQLIHAAQKYQNTVTAITPQSTQLLQSIEGSIKPGRSKGKTLTESYKTVLGRIRPAKTKGSDTAINAWTALRRPSLFTTRAEVRSLFPYCLFRVAHHPVTCKLSLLTRFRLYNQSLQLPKNSNDPQFTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K6</accession>
    <name>E8X2K6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2186</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580546.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2186"/>
    <dbReference type="EnsemblBacteria" id="ADW69230">
        <property type="protein sequence ID" value="ADW69230"/>
        <property type="gene ID" value="AciX9_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2186"/>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_0"/>
    <dbReference type="OMA" id="ECTKHLG"/>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="4">
        <location>
            <begin position="286"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="53888" checksum="76BEEBAB9722757A" modified="2011-04-05" version="1">MIHESTERAAPDQVLVDIADYVFGYEVESELAYATARLCLIDTLGCGLEALEYPACTKLLGPVVPGMTVPHGARVPGTEYELDPVQAAFNIGTMIRWLDYNDTWLAAEWGHPSDNLGGILAVADWLSRAAVAQGLAPLTMRAVLTAMIKAHEIQGCLALENSFNRVGLDHVVLVKVASTAVVSQMLGLTYEQTTAALSLAWVDGQSLRTYRHAPNTGSRKSWAAGDATSRAVRLALIAKTGETGYPSVLTAKKWGFYDVSFGGREFTFQRPYGSYVMENVLFKISYPAEFHSQTAIEAAMTLRSRMQALGRTADEIVKITIRTHEACLRIIDKKGPLNNPADRDHCVQYMVAVPLIFGRLTAADYEDQIASDPRIDALRDKMRCVEDALFSEDYLDPAKRSIANTLVIELKDGTLLEETVEYPIGHKRRRADGIPLLQAKFEANLARRFSVGQQKQILEASAEQGRLEAMAVNEYVDLFVPEIGTNAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M0</accession>
    <name>E8X2M0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2200"/>
    <dbReference type="EnsemblBacteria" id="ADW69244">
        <property type="protein sequence ID" value="ADW69244"/>
        <property type="gene ID" value="AciX9_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2200"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459363_0_0_0"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="20219" checksum="A6F7627363912FEA" modified="2011-04-05" version="1">MATSVLIPISEYLKTTYRPDREYLDGEVVERHVGKWEHSRVQALLTGWFIQHERSWNIQTATEWRTQVSSTRVRIPDLVLVRSGAQPEVLEDAPLLVIEILSPDDSYSDTQQRAEDYLRMGVTTIWIIDPSTRTGRVCSGSNWMQRERLEVAGTAIYVPLDRVFEALVSGGVVEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U5</accession>
    <name>E8X2U5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ordered locus">AciX9_3385</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581704.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3385"/>
    <dbReference type="EnsemblBacteria" id="ADW70392">
        <property type="protein sequence ID" value="ADW70392"/>
        <property type="gene ID" value="AciX9_3385"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3385"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_0"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="611" mass="67102" checksum="BBACC85F5DCB261F" modified="2011-04-05" version="1">MSSSTKQAIRNIAIIAHVDHGKTTLVDAMLRQSGTFRSNEAVAERVMDSNDLEKERGITILAKNTAIQYHDSKINIVDTPGHADFGGEVERALKMVDGVVLLVDASEGPLPQTRYVLSKALEAKLTPIIVINKIDRPDARVQEVLNEVYDLFIDLDADESILDFPVIYTNGKAGTATMDMSVPGTDLQPLFELIFKTIPEAPGTADGDLQILVTNLDYSDYLGRLAIARVFNGTLKVGQEVNLSKIDGTLVPVKITKLFTFNGLKREDTTETAVGDIVAIAGIPGITIGESFCALENPKPLPIISIDEPTIAINFSVNNSPFAGREGKYVTSRNIKDRLERELLTNVSIRMEPTESAETFKVLGRGELQLSVLIEMMRREGFELLVSRPTIVTKRVDGNLMEPSEILTIDIPENFVGTVIERLGPRKGEMVKMANHGSGRVRMEFKVPSRGLIGLRNEMLTETRGTIVMNSIAGDYIPYQGEIPQRPSGALISDRQGTTTTYALDGVQERGVLFIGDGVEVYEGMLVGEHSRDNDLDVNAVREKKLTNMRASGSDDAIRLVPFKILTLEQSIEFIADDELVEVTPKSLRMRKKVLAANRRPKGNRGGSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y8</accession>
    <name>E8X2Y8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine/cytidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1059</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1059"/>
    <dbReference type="EnsemblBacteria" id="ADW68122">
        <property type="protein sequence ID" value="ADW68122"/>
        <property type="gene ID" value="AciX9_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1059"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_0"/>
    <dbReference type="OMA" id="TTLKPMH"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="5">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="24627" checksum="FA9D73E398E86A4E" modified="2011-04-05" version="1">MGVLTDSAQLTFPRKPFILGIAGCSGSGKTTLARELASELSATLLTLDLYYHDLAHLSHEERATQNFDHPDSLESTLLTEHVRQLAAGNPIQAPTYDFATHTRIPDAEETIRPTDFIIVEGILALHYEPLRALYNLSIYVDAPHEVCLMRRIHRDVKERGRTEESVRNQYLETAHPMAEQYVLPSAHHATLTVEGTDSLDWSVEQVLSTLRKHGYTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X372</accession>
    <name>E8X372_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="11" type="ordered locus">AciX9_2258</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580612.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2258"/>
    <dbReference type="EnsemblBacteria" id="ADW69296">
        <property type="protein sequence ID" value="ADW69296"/>
        <property type="gene ID" value="AciX9_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2258"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_0"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="360"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="405" mass="42879" checksum="6AE0AC7DC9219A39" modified="2011-04-05" version="1">MAKLSIRDLELGGKRVLIRVDFNVPLSKDGREILDDTRIRETVPTIEYALRRKARVVLCSHLGRPKGKVVPALSLRPVVDRLRELLDHVLGEDENVGFAPDCVGEVATELVNGLEQGQTLLLENLRFHAGEEANDPVFAKKLAALCDVYVNDAFGSAHRAHASTEGITHFVKESAAGLLMESELEHLGKALTEPDKPFVAIIGGAKVSDKIGVIEAMLEKADAVLIGGGMAYTFLRAMGQDTGKSLVEVDKVDVAGETLKKAAAKGVRFLLPVDHVVADRFAADAARGVWKAPAGIPEDKMALDIGPETVELFAAEIAGARTVLWNGPMGVFEFPAFAVGTNAIAEAVAGNDEATTIVGGGDSVSAIHKSGFAGKITHISTGGGASLEFLEGKVLPGVEALTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E9</accession>
    <name>E8X3E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581761.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3445"/>
    <dbReference type="EnsemblBacteria" id="ADW70450">
        <property type="protein sequence ID" value="ADW70450"/>
        <property type="gene ID" value="AciX9_3445"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3445"/>
    <dbReference type="eggNOG" id="ENOG5031C19">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086678_0_0_0"/>
    <dbReference type="OMA" id="GWGILGH"/>
    <dbReference type="OrthoDB" id="1280727at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230626" evidence="1">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="31110" checksum="56A3CD510E679AA6" modified="2011-04-05" version="1">MPDAIRTLRRTAALLPLLLSLLTAGAQAQDLKDPKGLVSAAVQSELNANRTDHTAFIYRDHDTTPDHDTLNLVVETPEGLLQRRLENNGHPLNPDERRADDANINALLANVDLQRKRKKDSVHDDQQAEDFLKLLPVAFIWTLDHEQGELVYLNFKPDPNYNPSTLEQRVLSALAGQIVISLPQKRIRTIKGALVDDVKFGYGLFGRLHKGGSFQVERREVAPRHWQVTESRVHLSGHALFFKNIGDQEDEIKTDFRISPAETLKQADEILKQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G8</accession>
    <name>E8X3G8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ordered locus">AciX9_1096</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1096"/>
    <dbReference type="EnsemblBacteria" id="ADW68159">
        <property type="protein sequence ID" value="ADW68159"/>
        <property type="gene ID" value="AciX9_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1096"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_0"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="162"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="278"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="401" mass="42491" checksum="3B4C2B535510A795" modified="2011-04-05" version="1">MASYTGCTCDKATPHVKKIAILGSTGSIGTSTLSICEQFPLRYTPIALAAGSNIEVAFAQAKQWRPKLISIATEPLADALKLRLRTEGITGIEVLSGIPGTIAVATHPEVEFVVSAIVGVAGLEATYAAVQAGKTIGLANKECLVAAGDLIISAARAKNVALLPIDSEHNAVHQAMRGGTPAEVKQIWLTASGGPFRNTPLEQFQHITPHQALKHPTWVMGQRITIDSATMMNKGFEVIEACRLFDLPAAKVRVTVHPQSTVHSLVEFIDGSILAQISVTDMRLPILYALAYPERPASNLTFDLAQLSQLDFSQPDLAKFPCLRLAYEAADAGPSACIALNAADEIAVAAFLAGHIPFLGIPRTIERVLELTPAANPTSIQGVLAADQAARTCAREVIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I0</accession>
    <name>E8X3I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1108</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579494.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1108"/>
    <dbReference type="EnsemblBacteria" id="ADW68171">
        <property type="protein sequence ID" value="ADW68171"/>
        <property type="gene ID" value="AciX9_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1108"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_2_0"/>
    <dbReference type="OMA" id="FGGCPMA"/>
    <dbReference type="OrthoDB" id="1111394at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="287" mass="30634" checksum="F05BFCC4928A68C3" modified="2011-04-05" version="1">MVKIIECPRDAWQGLPKVMAPEVKADYLRVLIAAGFKHIDAVSFVSKTALPQMADSELVLEYLDPPDDVEIIGIVVNEKGAERAVKSGAVQTLGFPYSISPGFLQRNQNQTPEESLEALEAVGTIGYKGGLEVVAYLSMAFGNPYGDAWSIDEVVDACDLLVDCGVKQISLADTVGLATPRMVADVLSDVMAVHDRIEIGVHLHARPEMAAEVIAAAYGAGCRRFDAAIGGMGGCPFAQDALVGNVPTEVLIAELKRLGAELPDMRPLDGLLAAAREIEKRYGTVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I5</accession>
    <name>E8X3I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KpsF/GutQ family protein</fullName>
            <ecNumber evidence="8">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1113</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579499.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1113"/>
    <dbReference type="EnsemblBacteria" id="ADW68176">
        <property type="protein sequence ID" value="ADW68176"/>
        <property type="gene ID" value="AciX9_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1113"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_13_1_0"/>
    <dbReference type="OMA" id="LMACLMR"/>
    <dbReference type="OrthoDB" id="571638at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="33280" checksum="E0251910DAD69BCF" modified="2011-04-05" version="1">MNEAGVAEFVRVEAAALAGLAERLDGEMGVAVERALGLLEGCAAGGRRVICTGIGKSGIIARKIAATLCSTGTAAAYLHPAEALHGDLGMAAKGDVVVALSYSGETEEVLRLLPAFERLGVGVVSFCGCSSSTLARGSAVVLDVSVSEEACSLNLAPTASTTVMLALGDALALELSRRRGFAAVDFAGLHPGGRLGRRLARVRELMHSGEALPTVSVETSMPEMIHEMSRKRLGMTVVLGAGGGLAGIVSDGDLRRLLEKAGAESFGKTAGEVMNGSPVTIPSGMMAADALVLMEERKITALVVVDGEDVVGVVHLHDLFEMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L7</accession>
    <name>E8X3L7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ordered locus">AciX9_1145</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1145"/>
    <dbReference type="EnsemblBacteria" id="ADW68208">
        <property type="protein sequence ID" value="ADW68208"/>
        <property type="gene ID" value="AciX9_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1145"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_2_0"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="82"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="383" mass="40975" checksum="B206F72E4F583008" modified="2011-04-05" version="1">MALTPKTLPIPSTKTIHLSATSTEYDIHIGQGLLSTLHPRLQKLAGGKSYRPFLITSPNIWKLWSKQVRASFPEAESPTVLFLPPGEKHKRLPAVESLAEQLAQHGADRDSILIAFGGGVLGDITGFLAAIYMRGIPYVQIPTTLLAQVDSSVGGKTGVNLAAGKNLIGSFHHPRAVFADIALLKTLPPLELRSGLQESIKAGIIADPKLFAYLEQNNELIANGDPEALTKVVTASIKVKANVVAKDERESGLRMTLNFGHTLGHAIEAATGYKKLLHGEAVAWGSIAALHVALARKVIDPDTFARMANLILSYGPLPRFKATASDLVALTSSDKKTRSGRRAFVLPTGIGSTEIVYDVTDEELTAAAESMLQTMRATGVKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q8</accession>
    <name>E8X3Q8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2298</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2298"/>
    <dbReference type="EnsemblBacteria" id="ADW69336">
        <property type="protein sequence ID" value="ADW69336"/>
        <property type="gene ID" value="AciX9_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2298"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045115_0_0_0"/>
    <dbReference type="OMA" id="RFIRNDN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038215">
        <property type="entry name" value="TN5-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014737">
        <property type="entry name" value="Transposase_Tn5-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014735">
        <property type="entry name" value="Transposase_Tn5-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14706">
        <property type="entry name" value="Tnp_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DNA_bind" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="50986" checksum="E5B30023F39834EE" modified="2011-04-05" version="1">MLLGQLSERVGSSIPFACQDWASTKAAYRFLSNKRVSEEKILAGHFTCTRERFKATSDTTVLVLHDTTEFIYRREESAAIGIVSKLPTRYGSRPRYHTTCGVLMHSSLVVTEHGLPLGLTAIKFWTRDKFHGANALKRRINPTRVPIEQKESYRWLENLRQSTALLQHPERIVHIGDRESDIYELFCIAQEMGTRFLLRTCVDRLAGEGGQTVSDAMEAAPIKGLHRIKVRNRKGETSEAVLELRYRRIRLHPPIGKRKLYPDLDVTVLHATESHPPKDRDRIDWKLITNLPVHSRKDAVEKLRWYAMRWKIETFHKILKSGFKAEEVRLRAAERLVNLIAILCILSWRIFWMTMMNRTTTTAQPDTVFTTTELYLLDQLVRDKPGKSPSESTLTLYMTKLAQLGGYLARAKDPPPGNTVIWRGLSRLTDIQLGFLLRTQLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S7</accession>
    <name>E8X3S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter periplasmic binding protein, urea carboxylase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2318</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2318"/>
    <dbReference type="EnsemblBacteria" id="ADW69355">
        <property type="protein sequence ID" value="ADW69355"/>
        <property type="gene ID" value="AciX9_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2318"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_3_2_0"/>
    <dbReference type="OMA" id="NIDACTM"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017793">
        <property type="entry name" value="ABC_transptr_urea-assoc_sub-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03427">
        <property type="entry name" value="ABC_peri_uca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="41647" checksum="425B0FDCF970AB03" modified="2011-04-05" version="1">MAQILTRAVLKSGTIERGSLPQIRRCCKMSLIAAAVLVGLLQTSAAPKALAEPATFTVGWSVYAGWNPYFYMQKSGILKKWADKYGIKIKVQRFDYAASLDSFVAKNIDACTMTNMEALDMPAASGVDSTVIITGDYSNGNDAVLTRNGLTFDKLAGHRVMLVQKTVSEYLLERGMVMSGQQAKLGSLKLLNTSDSDIAPAFLNNASNEAVVTWKPLVSQILVDKGVHSIFDSSQIPGEILDLLVVRTEVLKRPDGSGEKFAKAMNGAWYETMQRLTGNGAPQAEALKVSAAASGDSVDSYKSQLKTTALFSTPKAAADFTTSPTLKQKMDLVRQFCFAHGLLGKSTKSVDDVAIAYPDGSVQGKKDRVKLRFDAGYMQAAQQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X2</accession>
    <name>E8X3X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3475</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581791.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70480">
        <property type="protein sequence ID" value="ADW70480"/>
        <property type="gene ID" value="AciX9_3475"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3475"/>
    <dbReference type="eggNOG" id="ENOG502ZDPT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2180133_0_0_0"/>
    <dbReference type="OrthoDB" id="2199711at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230207" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="11609" checksum="34F499FCF49D6CBF" modified="2011-04-05" version="1">MIYSSLAVLALAASSTLASAAMPLGNLVHLHPHSQTDTRVVVTLVNKSQSFRDVKIGGRNYTVTSHGTLAVKAPAGTVIYVNSYMPNHHVGDTLLDLSPEQNNTKVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z8</accession>
    <name>E8X3Z8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ordered locus">AciX9_3501</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581817.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3501"/>
    <dbReference type="EnsemblBacteria" id="ADW70506">
        <property type="protein sequence ID" value="ADW70506"/>
        <property type="gene ID" value="AciX9_3501"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3501"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_0"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="310"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="424"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="453" mass="48815" checksum="114DD65DF8596817" modified="2011-04-05" version="1">MSQSQPASKSQRQSAVILGAQWGDEGKGKIVDVLSEKFDVVARYAGGHNAGHTVIIHGRKFVLQLIPCGVLRPDCKGVIGNGVVLDPAAFLAEVKKLKDAGLPVDGQLFVSNRAQVILPYHRMIELAAETAPGRTPIGTTRRGIGPAYEDKIHRNGLRVADLLNSSLLRTHINNACHEKNTIAHALFGTEPLDPRAMYEEYVKLAEQLAPYVTDTAVMLNDAIDKGQNVMFEGAQGALLDIDHGTYPFVTSSSATAGGAVTGTGVGPTKIGTVIGVTKAYVTRVGEGPFPTEIDGHSADLLRARGQEYGAVTGRPRRCGWLDLPLLRYSNMINGTEWLVVTKMDVMDECAEIPVCTGYKIDGKVTDVIPADIRGFESIKPIYTTLKGWNCSTEGITEFDKLPQLAQDYLHFIERESNAKIGMVSTGPDRIQTMTMPEFDTLLGGVNVNGTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X421</accession>
    <name>E8X421_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase cyclophilin type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3524</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581840.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3524"/>
    <dbReference type="EnsemblBacteria" id="ADW70529">
        <property type="protein sequence ID" value="ADW70529"/>
        <property type="gene ID" value="AciX9_3524"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3524"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684694_0_0_0"/>
    <dbReference type="OMA" id="FGQCDDA"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234149" evidence="1">
        <location>
            <begin position="27"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="230"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="402" mass="42745" checksum="0F762CED7513F3A8" modified="2011-04-05" version="1">MYNQRMRRLALLAAILFSAIRFTALGQSQPRAVIDTTAGRLTCTLFTHERPATTAAFIALAEGTKAWTAPDGSMERDQPFYDGTRIFPHSAGIVTGARAAKEERAAGAGFAVEAAPPLRFDRAGLLAMTEAKGEAGPSRFLVTDHANAEVDGHAVVFGECDEASVKLVARLRRELQATDNHPAKDVAIRRVVIVPAGKALPGVAAVDANVVVLPAPSAAPLAAPAGPEPTGPVAVIETSVGTISCRLFTKESPIATATFLSLVDGSKDWTDPRTRAVQHGHRFYDGQAIDRVLPDYYIQFGDITGDISGDTDIGFRFKNESAPGLTFDRPGRLAFGNGGPDTNNSELFFALNPMHVLDGGYTIIGQCDGASMKVLERVAGLARDSSNRPLTPVVIRRISTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X436</accession>
    <name>E8X436_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0005</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0005"/>
    <dbReference type="EnsemblBacteria" id="ADW67096">
        <property type="protein sequence ID" value="ADW67096"/>
        <property type="gene ID" value="AciX9_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0005"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_0"/>
    <dbReference type="OMA" id="NNQMILN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="311"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="530" mass="57990" checksum="4742F66CF6601050" modified="2011-04-05" version="1">MGSTNRPDSTAEDRRLEALRQFSILDTLPEQGYEDVTELASFICGTPIALVSLVDAERQWFKSVRGLEARETPVSQSFCAYTVPTGETLIVTDARTDERFKNNPLVLGDPNIRFYAGAPIVEANGYVLGTVCVIDTEPRELSAKQVRALEALARQVMSMMELRKAIAAEAKATETTRLAQESAKIASWEWEVESGRLSWSGDSAWIYGRPAEELAHIDQVLPCVHEEDLHVLQGSMADSLAGGGEFQNEFRVVWPDGSTHLIVGQGSTVLKASGEVARVVGINRDVTQRRLTEEALRQSEKLAAVGRLASTIAHEMNNPLESVTNLLYLAMTSGTLSEEAHTYLSTAERELRRVSAIANQTLRFHKQSSKPQRVSCEDLFESALLIHQGRIVNSGVAVQKRKRATETVLCFDGEIRQVLNNLLGNAIDAMSAGEGRLVIRSRNATDWVSGRKGLMLTVADTGAGMSAATQKRLFDAFFTTKGIGGTGLGLWVSKEIVERHGGALRVRSSQAEGHRGTVFCLFLPFDAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X448</accession>
    <name>E8X448_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_0017</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578437.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0017"/>
    <dbReference type="EnsemblBacteria" id="ADW67108">
        <property type="protein sequence ID" value="ADW67108"/>
        <property type="gene ID" value="AciX9_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0017"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_0"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="10">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW67108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="36143" checksum="40992B43A9A985E6" modified="2011-04-05" version="1">MTGHVTRMRRMRRTEALRSLVRETHLRPESLIYPLFIVPGEGVRKPISSMPGVFNVSVDEALKDAAECVELGLGGLLLFGLPPEKDEQGSGAWDEQGIMQTALRAIKRESGLKSLVTIADVCLCEYTSHGHCGIVARDGEEYAVENDSSVRLIAKTAASLAEAGADIVAPSDMMDGRVEAIRAALDEGGHQQTPIMSYAAKFASAFYGPFREAADSAPQFGDRKTYQMDGANRREAMREIEQDLLEGADMILMKPAMPYLDVLKEARDRYEVPIGAYQVSGEYSMLVAAFERGWLERERAIIESLLSLRRAGADFIVTYFAKEAGRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E0</accession>
    <name>E8X4E0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1204</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579590.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1204"/>
    <dbReference type="EnsemblBacteria" id="ADW68267">
        <property type="protein sequence ID" value="ADW68267"/>
        <property type="gene ID" value="AciX9_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1204"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_0"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="59663" checksum="E10B2AB2EFCAEBBA" modified="2011-04-05" version="1">MLQERVSGVLLHVTSLPSYGGIGDFGPEAYNFVDFLAASKQRIWQVLPLSPTGYGSSPYSALSAFAGNPILISLEILADQGWIDRDRIANLAPHSGPCDFGRAATEKLPLVEEAAANFLDRATGDQRLRFQKFCTDNHSWLSDYAMFTVLRRTYEYASWHEWPEEYARRKSDALATLMNERGRELAIEQAVQFLFSEQWCTLRGYCADRKIQILGDVAIFVNYDSADVWTNPDIFELDDQLRPIRVSGVPPDYFSATGQRWGNPLYRWSTLKERGFDWWVARIRRSLTLYDVIRLDHFRGFEAFWSIAADEETAINGQWVKAPGHDLFQRLRDVFGDLPFVAEDLGVITKEVDELREHYGMPGMRILQFGFTDRGSHLYLPHRFVPNTVTYTGTHDNNTTLGWWLDDTGEAERANAQTYLGKIDHPAEIVWAMMRAAARSVANVCIFPLQDILHLGSDARMNTPAGIGQNWAWRYDQGTLHPDFAYQLGALMEMTDRDGYSAPVEGTEAAGKPTEDASKRAELGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G3</accession>
    <name>E8X4G3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1227</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579613.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1227"/>
    <dbReference type="EnsemblBacteria" id="ADW68290">
        <property type="protein sequence ID" value="ADW68290"/>
        <property type="gene ID" value="AciX9_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1227"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_0_0"/>
    <dbReference type="OMA" id="SRRHYCF"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230221" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="42"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="415"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="690" mass="76238" checksum="290E033B30992E90" modified="2011-04-05" version="1">MRFPILRLPQTLLAALLLALIPSASFTQATTPQPPLLLGAAWYPEQWPEAQWDHDLTLMEQAHMHVVRVGEFAWSTMEPSDNHFDFVWLDHAIAAAAKHHISVVLGTPTAAPPAWLTAKYPETLRIDEGGRRDEHGGREQFSANNPKYRELCVRVAHAMAARYGHNPNVLGWQIDNEIGDPTFDDSAKLQWHQWLQKKYGNIADLNRRWTTAYWSQTYDTFDQVPYHSRGENPALLLDYKHFVTDTWTSYISAQADTIRPLALKSQFITTNTMGWFSTYDHYIMHKNLDMAAWDDYVPDGHPDYPRNAALHDLVRGYKQKNFWVMETQPAFVNWGPINTALPPGVTREMAWQAIGHGADAVLYWQWRSALNGQEEYHGTLVGADGEPVPIYSEIAKLGADFAAAGPALAGTSPHAQVAILQSYDAHWAIDFQKHSADFDYPKNVLDTYRAISPIAQTIDVISPESDLTPYPIVFAPALNILSEAEAAHLLAYVKQGGQLVLGTRSAMKNADNGLDPHRQPGPFTEALGAHVDQFYALDPKDPAPTVSGPLGTGTASIWAEVLSTQPDTKVLLTYGPENGWLAGKPAAVSHPYGKGTLTYIGTVLDPKLMASVATQLLSAADIHPTLPNLPTGVELMPRTAPNKPPVWIIINHTNTPQHIILPANMKNLLTSSSAPTLDLPAHEVAVLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H1</accession>
    <name>E8X4H1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1235</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579621.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1235"/>
    <dbReference type="EnsemblBacteria" id="ADW68298">
        <property type="protein sequence ID" value="ADW68298"/>
        <property type="gene ID" value="AciX9_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1235"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420209_0_0_0"/>
    <dbReference type="OMA" id="FPGNHHP"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="PTHR15137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234161" description="Transcription initiation factor TFIID subunit 2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="7">
        <location>
            <begin position="288"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="661" mass="72319" checksum="DC501D9588318AA1" modified="2011-04-05" version="1">MKSFLKAVTAAAALTFATTALAAPTRPQLRVTAYVIHAELDPASSRLSATTAVTFTALEDLSTPTFELNNGLALTSVTDSAQHTLTSERLSTQNAVRFTLATAIPKGTSTTWTFTYSGALTGSDTSPVEGIKLAAVADPISMLLYPGRWFPISQTGLYTDRFTAEMHIRVPSDERVVASGPVGTPVSVGKQTEYSFNWTKPGFPGTVVAGKFLAPQTVGNFKIYVTEKRKLGALAFGETAAKEFEFMSTTFGQPETGAMSIVELPEDGVSASWGPGIAAIAGNRIMDHNSARLLANTLAHQWWGSEVSPATLNDAWITNGMSRYAELMYVEDASGSQAFQTAVGDVSAGALAYDTEPLSTLGRLDPFSPQFQSMTLEKGAMVFHMLRWEMGNEGFTRFLRETLSQYTDKGIRSRDLETVAEAQNRNAGGEQSTLQPFFSQWVDGTGAPQFNDKYTVYRLGNNKGFRTVGAITQDLDLFRMPVELRIETEGKTETRRVDVAGTDSQYEVETFGRPRRITIDPQGWLLKTTPDLAVKVAVLRGQQLVAQGDLTGALVEYQKALDANKNSSLAAYRIGEIFFNQHNFQSAANSFRDSLRGDGDPKWTEVWSHVELGRIFDVTGQRERAVNEYRLAVQTNDNTQGAINEARNLMIHPYTRTPTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H5</accession>
    <name>E8X4H5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1239</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579625.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1239"/>
    <dbReference type="EnsemblBacteria" id="ADW68302">
        <property type="protein sequence ID" value="ADW68302"/>
        <property type="gene ID" value="AciX9_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1239"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_2_0_0"/>
    <dbReference type="OMA" id="GVSQPHW"/>
    <dbReference type="OrthoDB" id="1323133at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="23892" checksum="2DE4D8DEF8086DA9" modified="2011-04-05" version="1">MILWNSFVLAFSALLPLINPLGSALVFLGLVGEASPQTYRILARRIAINTAIFLAVIELLGSALLNFFGISLPIVQLSGGMVVAAIGWSLLNEKDAQAATNNKKMELEARTEAHDETLSQKTFYPFTFPITAGPGTVVVMLTLSAHASDHVVSTNVLAHLGVFLAAVVLCALVYICYAFAPAITRAIPPSTAHGVLRVIAFILLCIGVQIAWNGLSALIATLHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X7</accession>
    <name>E8X4X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0078</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578498.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0078"/>
    <dbReference type="EnsemblBacteria" id="ADW67169">
        <property type="protein sequence ID" value="ADW67169"/>
        <property type="gene ID" value="AciX9_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0078"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="FYRHQTQ"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="44"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="45635" checksum="3E990D19D02BA521" modified="2011-04-05" version="1">MATENNQRSTSFDKTLASATTTIAFREIISLAIDSFRASKFRFLLTMLGMVIGSASIILVVTVGLTGKQYALDTISGLGPNKVEMQYAGGEVMGPNNVSTPDFMTRDDMRAVIEQVPGIVASSPMLEYHNNISIGNGVTKNAMLLGVSPQYRQVRNLKLIAGRFFDDQDATTHANVVVMVAPLAKELYGSTQAGVGSTITVTGIPFTVIGIFTESIDTFGTSEISDRTLLTPYEVARYFEGTETLKEIFFSMKDSSEVEPAAKRITEIIQSRHRPTSVYKAQTLTDILATMSKIANILTVVLTLAAGFTLIVSGVGIMNSMLANVQARTREIGIRKALGATNREIRLQFLTEAVFLSLAGGIVGCACGIAVPLSVTFLTPFKLPFDWLSVLIALSTSVLVGVIFGTLPSNRAAALDPVETLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X501</accession>
    <name>E8X501_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde reductase</fullName>
            <ecNumber evidence="5">1.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0115</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578521.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0115"/>
    <dbReference type="EnsemblBacteria" id="ADW67193">
        <property type="protein sequence ID" value="ADW67193"/>
        <property type="gene ID" value="AciX9_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0115"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_0"/>
    <dbReference type="OMA" id="NWVPLPK"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:alditol:NADP+ 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="34771" checksum="CB2C3BC69A8E03F1" modified="2011-04-05" version="1">MFEYPELRMTTMPLNHGRGQIPALGFGTLIPDPAVTVTATQDALEAGFRHFDCAERYRNEREVGEALQAGFAVGGIARQDVFITTKLWNSNHRPERVAPAFEASLDRLRLDYLDLYLIHTPFAFQPGDEQDPRDQNGKVLYDDGVTLLDTWRAMESLVDGGRCRAIGLSDITLDRLLPLYESARIKPAVVQVESHPYLPETELLEFCKKHGIVFLAFAPLGHGMKPGLLEDPVISAIAARVEMTPAQVLLAWAVQRGTALLTTPKTAARARENYNIQPLPKDAFDEINRIQIRQRLNDVVNTGSPGFIPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X589</accession>
    <name>E8X589_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1291</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579676.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1291"/>
    <dbReference type="EnsemblBacteria" id="ADW68353">
        <property type="protein sequence ID" value="ADW68353"/>
        <property type="gene ID" value="AciX9_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1291"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_0"/>
    <dbReference type="OMA" id="RYFMDKI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="293"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="542"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="329"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="604" mass="66131" checksum="F0C3789CBE910A60" modified="2011-04-05" version="1">MPPILNAQGVSKRFGAVPLFEEISFPVSEGDRIGLIGPNGAGKSTLLKVLAGEEDPDTGDVATRKRARIGYIRQESTFADRLTVRDVLEKAVEAAGVPEAEREGRLQETSGRTGFPDMTAEAARLSGGWRKRLAIAEAIVSGPDVLLLDEPTNHLDLAGIAWLEETLKSAPFACVLVSHDRYFLENVATEIVELNKVYADGLLRVKGTYTQFLEGKEQYLEAQSKLQDALKNRVKIETEWLRRGPKARTTKSKARIDSAQDLIGQLKEVNQRVQTSTAGIDFSATDRQTKRLVEFEGVSCTLGEGANARKIVENLDFLITSGMRVGLVGPNGSGKTTLLRLLREEIKPDTGEIKKAAFLKVVYFSQTRELDESVTLRRALAPDSDSVVYQGRVVHVASYATKFLFTSEQLNQPVERLSGGERARVLIAKLMLEPADLLLLDEPTNDLDIATLEILEESLLEYTGALVLVTHDRFMLDRVSTVVLGLDGKGGAERFGDYSQWEQWKGVKIEEAIVPGSSASAAGGGNDKGGKKKLSYLEAREYAGIEALVDKAEERLNAARDVLDDPSVATNAEALTKALHEMEQAQTEADGLYQRWAELTEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F4</accession>
    <name>E8X5F4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2468</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2468"/>
    <dbReference type="EnsemblBacteria" id="ADW69501">
        <property type="protein sequence ID" value="ADW69501"/>
        <property type="gene ID" value="AciX9_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2468"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058197_0_0_0"/>
    <dbReference type="OMA" id="PDSCVRQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="37015" checksum="D17A32A350828A9B" modified="2011-04-05" version="1">MPIALVFFVHYAYAILFLWVLVEQMGVPIPSIPVLLMAGTLSATHRVSAVGALLMVLLACLAADSIWYALGRRFGNSVLQLLCRFSFEASTCVSKTEGYFHKRGAVTLLFAKFVPGLSTVAAPIAGQTGMPYPRFVLYDMGGSVIWALAYLLAGRFFGDVAQKSSKFFGMLGHFAVVIFVLMVFGIMLYRLWNQRKFLASVRSLRLEPAELYSMIEMAEEQGNIPPFIVDLRHPLDYLPDPRVLPGAVRVSPAELTAHQSLLPRDRDVILYCTCPSEETSGKVALQLHKFGINRVRPLLGGFEGWRDGGYPLVEYVPPAAAAELTNPVTAAPVGAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I6</accession>
    <name>E8X5I6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="7">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3610</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3610"/>
    <dbReference type="EnsemblBacteria" id="ADW70613">
        <property type="protein sequence ID" value="ADW70613"/>
        <property type="gene ID" value="AciX9_3610"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3610"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_0"/>
    <dbReference type="OMA" id="PFFRVHE"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="76"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="433" mass="46826" checksum="A1314C4CBFC44796" modified="2011-04-05" version="1">MGPIKSDASNLTSSACTRKTFTIELMSLAVENHPQTRSQLAHLTAQLDTFRQAGTFFRLRELEDIQGPVCTYDGRKVINLASNNYLGLCNHPKLEEAAIQAIKDHGVGSGAVRTIAGTMRIHMELEEKIAAFKNVEACVVFQSGFSANAGTVSSILGKEDFILSDELNHASIIDGARLSKAKIKVFRHKDVAHCEEILQEIANEPGKKLIITDGVFSMDGDIGPVGELAALAEKYGGIMMVDDAHASGVLGRNGRGSVDHFDVHGKVDVQVGTLSKAIGALGGYVCGSRDLIDYLYHRARPFLFSTSHPPSVAATCIAAFDILENEPDRIQRLWDNTAYFKQQLAHSGFNIGGVNTPASETPITPIIIGEGRKTMDFSKALFEAGLMATGIAFPTVQEGKARIRTIMTSEHTRAQIDQSLEILTTTAKTLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L0</accession>
    <name>E8X5L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581948.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3634"/>
    <dbReference type="EnsemblBacteria" id="ADW70637">
        <property type="protein sequence ID" value="ADW70637"/>
        <property type="gene ID" value="AciX9_3634"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3634"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_9_1_0"/>
    <dbReference type="OrthoDB" id="2090518at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="10954" checksum="F32F6414C8A12B96" modified="2011-04-05" version="1">MSDSVQDRVLKVVETARQKPAGSITPDSTFEELEIDSLDRLNLLFDLEGEFDIQIDDEQAKTVTSLREMIDGIQLLVDQKAEKAEKDATDAKAKASPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R2</accession>
    <name>E8X5R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion system lysozyme-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572708.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70796">
        <property type="protein sequence ID" value="ADW70796"/>
        <property type="gene ID" value="AciX9_4000"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4000"/>
    <dbReference type="HOGENOM" id="CLU_102944_0_0_0"/>
    <dbReference type="OMA" id="IERHEPR"/>
    <dbReference type="OrthoDB" id="1918415at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017737">
        <property type="entry name" value="TssE1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03357">
        <property type="entry name" value="VI_zyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="17749" checksum="AE78DBCAE604CB38" modified="2011-04-05" version="1">MAKSKAENLVTQSLLDRLCDVDDWPTTRQQSMRVYRESIKRDVEYLLNSRRPPIEDINLYPRAAASVINYGLPDIHSYSESAGDQSALMTAMLQTLRRFEPRIQGVRVFVSRGEAMTRSLQFRIEGRIQFDTQVENIEFDTVLELTRGEYEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R6</accession>
    <name>E8X5R6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion protein, EvpB/VC_A0108 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572712.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70800">
        <property type="protein sequence ID" value="ADW70800"/>
        <property type="gene ID" value="AciX9_4004"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4004"/>
    <dbReference type="HOGENOM" id="CLU_018386_1_0_0"/>
    <dbReference type="OMA" id="EYGWCTS"/>
    <dbReference type="OrthoDB" id="683477at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010269">
        <property type="entry name" value="T6SS_TssC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044032">
        <property type="entry name" value="TssC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044031">
        <property type="entry name" value="TssC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35565">
        <property type="entry name" value="PTHR35565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05943">
        <property type="entry name" value="VipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18945">
        <property type="entry name" value="VipB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03355">
        <property type="entry name" value="VI_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VipB" evidence="1">
        <location>
            <begin position="72"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="VipB_2" evidence="2">
        <location>
            <begin position="381"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="497" mass="54775" checksum="5A1156B6C869CD3A" modified="2011-04-05" version="1">MSSAANPLASASTAEAVETGEPSLLDQIVAQGRFSREAGDLERGKDLVKEFVSQVLEGQMTLSKDAEATISARIAQLDRLISIQLNEVIHHPSFQKLEATWRGIKYLMDQSETNDMLKIKVLNASKKDLLRDLQRAPEFDQSALFKKVYEEEFGVFGGAPFAAMVGDYEFGRGPEDLELLEKIGQVASAAHAPFLSAAAPGLMNLSDYTQLGAPRDMSKIFDSTEYAKWKSFRQSDDSRYVALTLPHILMRQPYGQDTKQIEAFAYEEAVDGRDHSKYLWGNAAFGLAARMTNSFARSGWCSAIRGVEGGGLVEGLTAHNFTTDEGDVALKCPTEVTITDRREKELADQGFVPLVHCKGTDKAAFFSVQTVNKPKLYDKPEANANARLSAQLPYIMAMSRFAHYLKAMMRDKIGSAMSRVEAEKFLNQWVNQYVLADDTGSAAAKAKRPLREARIEVMSVPGNAGALRAVAFMRPHFQLDELTVSLRLVADLPAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S6</accession>
    <name>E8X5S6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4014</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70810">
        <property type="protein sequence ID" value="ADW70810"/>
        <property type="gene ID" value="AciX9_4014"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4014"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_0"/>
    <dbReference type="OMA" id="NIAFHDR"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="26110" checksum="010F499CFC1764D5" modified="2011-04-05" version="1">MVEKLDPLPNLTELAYLSIKRSMLEGKVEWHQRLTEDMLASQLGISKSPVREALNTLQGEGLIRIESRRGAYLRQFTAQDVNDLYDLRGVLEAHAVAKAKVTPELLQALWQSVDDMKQGLQSHDKVKHIEEDNRFHALIAQATGNEELGGTLRNVQNKIWLCRSKSYDLSSSTAPAAHAAIVEALESGDKKKAQRCMRDHIETVRKRLVKRIDEESRPGAKDKGKDYGDKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X658</accession>
    <name>E8X658_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4162</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572854.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70942">
        <property type="protein sequence ID" value="ADW70942"/>
        <property type="gene ID" value="AciX9_4162"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4162"/>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_0"/>
    <dbReference type="OMA" id="YVAYHDT"/>
    <dbReference type="OrthoDB" id="1835478at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="21147" checksum="591EEB840D10B12D" modified="2011-04-05" version="1">MSNVMKRCGWAESDELMRGYHDEEWGVPQYDSRALWEMLMLEGFQAGLSWAIILKKREGFRKAFKKFDPKKVAKFGEADVERLMGDEGIVRARAKILATIGGAKIFLEMEKSGEDFSEFVWGIVGGTPIEGTGVVMAKTELSERMSKELKEKGFKFVGPVIVYAWMQAVGMVNDHATGCFRRTEMGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A0</accession>
    <name>E8X6A0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ordered locus">AciX9_4206</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70984">
        <property type="protein sequence ID" value="ADW70984"/>
        <property type="gene ID" value="AciX9_4206"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4206"/>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_0"/>
    <dbReference type="OMA" id="CGEIMTM"/>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="552" mass="58276" checksum="46ED9FE6E1D72887" modified="2011-04-05" version="1">MTISKNSQNALSENQPAALLPIQTIVKKLALPEQYVEQLGPYGAKVKLGLLEDVALPRRGKMILVTATTPTTSGEGKTVTAIGLTQGLERIGKSVVITSREPSLGPVFGMKGGAAGGGRARVEPADKINLHFHGDFHAITSAHNLLAALIDTHLFHGNDLDLDPASITWPRSMDMNDRALRRIVVQAGGKRDGHDRATGFLITAASEIMAILALATGRENLRARLARIVIGSTRAGEPVRAEQLDATGPMMALLTDALLPNLVQTSEGTPALVHCGPFANIAHGTSSVLSQYMGLQLADYVINECGFASDLGFEKYMDIVMPASGIKPAAAVLVTTLKSVTTQGEGNLERGFANLGKHIQILRGFGLPTVVAINQFPNDAPEELAKIEQFCREQGANFALSQAFSKGGEGAVALAEEVVRTIEANPEPKPISMYGPEDSAEEKIGKVARGVYGAKDVEFSDEARAKLAKFAEWGFGALPVCIAKTQYSLSDDPKLPGAPTGWTLHINDVSLSAGAGFLVAISGSMMLMPGLPKESRAALIDVDADGNVTGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A7</accession>
    <name>E8X6A7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70991">
        <property type="protein sequence ID" value="ADW70991"/>
        <property type="gene ID" value="AciX9_4213"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4213"/>
    <dbReference type="HOGENOM" id="CLU_751545_0_0_0"/>
    <dbReference type="OMA" id="NTCAMGH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230787" evidence="1">
        <location>
            <begin position="27"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="363" mass="40587" checksum="68671A7670791B2E" modified="2011-04-05" version="1">MMSMGRRLTGLAAGLILASGAVVAGAQTDYFNNWPQGTSPAEVGKALSEHFVTSPHQYTATIHYSEAASWYGALTFAQLTHDDALRAELIKKFEPLMPGGAEASHIPLRKHVDDEIFGIVPLEIGLQTKEPRFLTEGKKWADRQWENPQPDGLSSETRYWIDDMYMLTILQLEAFRATGDRKYLDRDAREMVSYLARLQQPKGLFFHAQDVPFYWGRGDGWVAAGMAEMLRSLPADHPQRPAILAGYKKMMAALLKYQGKDGMWRQLIDQDDAWPESSSSAMFSFAMITGVKNGWLDAASYGPAARRGWIATVGYVDQNHDITSVCEGTNKLADRAYYLARKRRTGDFHGQAPMLWAASALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F3</accession>
    <name>E8X6F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4262</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71037">
        <property type="protein sequence ID" value="ADW71037"/>
        <property type="gene ID" value="AciX9_4262"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4262"/>
    <dbReference type="HOGENOM" id="CLU_3344195_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="37" mass="4320" checksum="7C764261D0E85A97" modified="2011-04-05" version="1">MCLRLEFNIRELIKVFSGNYDLCGSLYENLAVDDSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X1</accession>
    <name>E8X6X1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3794</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582102.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71080">
        <property type="protein sequence ID" value="ADW71080"/>
        <property type="gene ID" value="AciX9_3794"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3794"/>
    <dbReference type="HOGENOM" id="CLU_000445_28_2_0"/>
    <dbReference type="OMA" id="SEAGHEM"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234263" evidence="2">
        <location>
            <begin position="23"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="866"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="982" mass="108266" checksum="B2C1E1B3BD140570" modified="2011-04-05" version="1">MRAPSLVFFILTFAARLLYAQADDDLRHLTLSSWTTGQGLPQNFITAIDQTPDGFLWVGTRGGLARFDGLNFRTSFANEPAGIHSAVNDIAHDADGRLWITTNLGLISETHGIWQQVSLPANENGQPGRLARSHDGTLLVRLGETVWHLDPRTLHFSPVYGMPAKLRSFAEDGSGNLWLTDGEAVTEIEPGGKTSRFPLHDAGLIKVERDGRVYAGDGHHLYRFEGTGFMRMEKSGTEEFVDMTIAHDGSLWMAAGGLEGISRKTGQGLQRMSMREGLASNDVRLLFEDRDGAMWLGTISGLQLLRRGSFVSYANEGLAAVTAQYDAIFQAADRSIWTGTLQDGISVFRDGRWKTFAIKEGVRRGQVRGFAEDGAMPIVAIADYGLFRWNGRRYEKMPNVPAGYVTSPLRTADGSLWFSIVRQGLFRLRDGKLQSFGAAEGLTDTRIWCLLPDHEGGVYAGSNGGIFHFSNGQWKHEFLELHETVLTLAYNSAGELLAGTNSGLTILGHSGAKTIGRAQGLLSDPVLQLVEDAERSVWVATSAGISRITAPQMDAFRTGRSQKVIPQLFTDHDGLPSRDLLPVSHVLGLRAADGRLWFAMQRGPASGNALPEAAPVAMHDDIAIDGIGQPDETVRVRPGRHRLIFAFTAPSFDASEMIRFRYRLIGWDNAWIDAGGLREATYAGLPPGHFSFEVQAIGRGGVAGPIARIPSVDLLPFFWQTRWFVVLAAIIGIALIIEFTRRRTLLRARRMSLLFQERAAERERIAYLIHDTVIQDLIGATLYLEIAEMELAAGELDPSKPLEGLAARLRESIARSRSMVANLHATSLPEHSLLDVLRLAEAEFRLAAQPAFRVSYTGEPRAIDPLLRDEVYRVCREAIANAFRHANAQNINVHTDFEPHALAVEIVDDGLGMDETLQRIGRPGHFGLPAMRSHMERIGAAFSIESAPGKGTRVRLRTHTSSRTRVWSWLRAHGHGRLSRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z2</accession>
    <name>E8X6Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3815</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582123.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71101">
        <property type="protein sequence ID" value="ADW71101"/>
        <property type="gene ID" value="AciX9_3815"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3815"/>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_0"/>
    <dbReference type="OMA" id="RVVTTWF"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="46834" checksum="918705CD4E099BAD" modified="2011-04-05" version="1">MYAERRTKVRFFLAFWLFVLSGVAFLDRTNISIAGLQISTEYGLGNQRLGWIFSAFLIGYAGFQLPAGWLAARYGPRKVLTIGVLWWGVATALTTLLPSGISHAVLLLVAVRFALGAGEAVIYPAANQFVARWVPLEERGFINGLIFAGVGAGSGLTPPLLAWIISREGWRAAFWFSAVIGLIAGAVWWYNARDTPEEHSGVSPAELNEIRDGLSGPPAPRVTAAAGEAPRPSTQISWSAIFRRRDLLALMGGYFSFGYIAWIFFSWFFLYMAQVRGFDLKSSARYTMLPFISMTICCLAGGALSDRLTKSYGLRVGRCGLAAAALLLTAVFLILGSQVHSPQAAALILAGGAGTLYLSQSSFWSVSVDIAGRSSGVFSSLVNMGGQIGGALTASLTPWIGQRYGWTTSFALSAILAVFGAICWMTVHPERPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X791</accession>
    <name>E8X791_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4373</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573044.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71325">
        <property type="protein sequence ID" value="ADW71325"/>
        <property type="gene ID" value="AciX9_4373"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4373"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_0"/>
    <dbReference type="OMA" id="CINDRYI"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="21172" checksum="778BFBC90D9AA47D" modified="2011-04-05" version="1">MPKTLIGYARCSTDKQDLTAQREALVDLGVAAERIYVDHGLTGTNRARPGLNQALAAVRKGDTLVVPKLDRLARSVPDARSIADELAARGVTLALGQSRYDPTDPMGKMFFNILATFAEFESDLIRLRTREGMKIARAKGKLRGKQPKLSDKQQKELGRMHGTGQYTISDLAELFSISRPTVYRTLLRSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E5</accession>
    <name>E8X7E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4432</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573098.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71379">
        <property type="protein sequence ID" value="ADW71379"/>
        <property type="gene ID" value="AciX9_4432"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4432"/>
    <dbReference type="HOGENOM" id="CLU_153796_0_0_0"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="15362" checksum="08D37BDEEB283D1E" modified="2011-04-05" version="1">MQTILRIIERAGGWNPGLFIKIENAPYMALVLEAIEAGPSGLPTISVTHYGEQNGDLMRDPEMCFELRDGELDPWYYRNDYVGVEQWSRNNVRGQYIQLANLHAQHQRFAKVWDNSLSCQGFAEAYEQQLTQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I0</accession>
    <name>E8X7I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4468</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71414">
        <property type="protein sequence ID" value="ADW71414"/>
        <property type="gene ID" value="AciX9_4468"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4468"/>
    <dbReference type="HOGENOM" id="CLU_1480066_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19935" checksum="CD869B8FA28677C4" modified="2011-04-05" version="1">MIPLGYMAKCIALERPEWMHTPNVVDVYSVSDCVNDSLLESTYIPDRPHNRYGLFDSPLAVQTAAKSNNVDMEGAKLFFYEAHESELDGDDWLPVSPDDSGETDVLLPATKQLEGFDVVTSCDGPNSHSPLSCNSVAADVKTNQHCLFETLNEALSALASGAFNEGEPGPYRVYAVYSVPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L5</accession>
    <name>E8X7L5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4505</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4505"/>
    <dbReference type="EnsemblBacteria" id="ADW71449">
        <property type="protein sequence ID" value="ADW71449"/>
        <property type="gene ID" value="AciX9_4505"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4505"/>
    <dbReference type="eggNOG" id="COG2232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054359_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="120"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="45984" checksum="368956555A105E34" modified="2011-04-05" version="1">MLVATTTWWPLSARIALAFLQSGCEVDGIAPRGNPMERVTALNRQFLYKAINPLGALRNALKQSMPDLIIPCDDRVVTHLHQLFHAEALRDIESPIAKLIVRSLGDPSGYPVTSNRARLLQLAKWQGVRVPETLIVHQPSDIGSWRSGRTFPLVIKADGTWAGNGVKVAHNLKESEQAFRRLQKRLTPVAAIWHMSEHNFYPIFENCAGSKPEIIAQTYIKGTSANAMFACWHGKVVGSVTVRVIAAKHELGASTIVRTMHHPKISAAAVLIVKELNISGFCGLDFIIQEGTGTPFLIELNPRATQLGHLKVGQSADLAACLCKALLGETFASAPDPSAEETIAFFPQIPLEQFKKLQSSYGDLIHDIPREDAELTEELMNVSWTERQWSARLCSSARLQALKIIKAICRRHTAASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N4</accession>
    <name>E8X7N4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573187.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4529"/>
    <dbReference type="EnsemblBacteria" id="ADW71468">
        <property type="protein sequence ID" value="ADW71468"/>
        <property type="gene ID" value="AciX9_4529"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4529"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137365_1_0_0"/>
    <dbReference type="OMA" id="GAHPRYE"/>
    <dbReference type="OrthoDB" id="2002329at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="11422" checksum="96F2472AD4DD1E49" modified="2011-04-05" version="1">MSKRIKVADLPEFDAAHYLDSETSIAAYLTDILEANDASLLASALGDIARARGMTEIAKRAGITREALYKALRPDSAPRFDTVSRVCAALGVRLVVQPVHPTPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R2</accession>
    <name>E8X7R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4565"/>
    <dbReference type="EnsemblBacteria" id="ADW71496">
        <property type="protein sequence ID" value="ADW71496"/>
        <property type="gene ID" value="AciX9_4565"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4565"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_2_0_0"/>
    <dbReference type="OMA" id="YRLMMLP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="498" mass="54131" checksum="ADEBD5E25452A513" modified="2011-04-05" version="1">MLTTQESVPPETLKSTFDAQELKKRSVQGGLLVMGAQAAKFVIKFGSAIVVARLLTPADFGMVAMVSPILGFLSTFNDLGFGQAIVQSPDITKEQISALFWRNMLISAGLAILLSLIAPLASKLYHEPRTTPLLMAMGGMLILATLGLVPNALLKREMRFGPLSAIDVAGLLIGTGVTIAAAAKGFSYWSLVIGQVATSLAGLVLAFMYTRWIPTRTLKAEKLGAFMRFGANLTLVNVATYFSMTADNMIVGAVSGKVQLGLYDRSYTLTIGPLNQLLSPISQVSVPLLSRLQDKPELYKTSYKHMLRIALTLTMPAMLFCVMTAKHLVPLMLGPKWTLAAPIFAWVCFGGLIAPLFSSTGWIFSTQNRTDEQMKASVATAFISIISFAIGVHWGAVGVACVSSLSFTFIQMPLMLYVMTRKGVITLPDVVQTLIPFIITTLLVAIPLYWMRSAWTLPQMVGLLLLSYSLFVVLLMMLPGGRDFVKMLRNIRGTLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S1</accession>
    <name>E8X7S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4575</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573224.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4575"/>
    <dbReference type="EnsemblBacteria" id="ADW71505">
        <property type="protein sequence ID" value="ADW71505"/>
        <property type="gene ID" value="AciX9_4575"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4575"/>
    <dbReference type="eggNOG" id="ENOG502Z8P8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045094_0_0_0"/>
    <dbReference type="OMA" id="VLIGFHI"/>
    <dbReference type="OrthoDB" id="379212at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="475" mass="52333" checksum="80B0022320772E4A" modified="2011-04-05" version="1">MIARCLARISPSHQKMWLLAAVACLSFVSPIARVLVYVLPLLSLILAVYFVRKDKTAYIELVCWLYMLTPLVRRYIDYKTGSTETTIMVAPYVAVGACLWVLVPQWTKIFQSRYAALLCVLAAVIYASATTAFQMLLGGLASGIAAWLMNLLFAFYLVIERKHIRTMYAGFERVMVYGTLVVGAYGILQYFIFPDWDRVWLELAELVSFGAARPMEVRVFSTMNAPQVVAAYLVVGIFISYGSKYKIRYLSLCAGLASLLLSMSRSSWVAFLAGALFLAFRLPTRERKKIVVIGAICLGTILIGLQVPALNETLTGRFNSLTDTNDNSAYDRTKTYSAVFHSIATSPFGLGLGVEGDEKGKESTSDAEHDSSVVNLLLCFGVIGSIVFCIGLFSASYRIVLAPKCELVIPLTPIQTSLFALIAEAALNNILTGPIAFLTWCVIGLGYATMEARIDVRRRSVPETLLHQGEPEVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X7</accession>
    <name>E8X7X7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4631</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573280.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71561">
        <property type="protein sequence ID" value="ADW71561"/>
        <property type="gene ID" value="AciX9_4631"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4631"/>
    <dbReference type="HOGENOM" id="CLU_1061446_0_0_0"/>
    <dbReference type="OrthoDB" id="1557327at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="277" mass="29822" checksum="0B21A6618A9CA241" modified="2011-04-05" version="1">MNPSYTAFKASLRKRRTRWIVGMALVLGTATPSFALFGLGDIVFDPTSYASLISQLSTLTNMYTTAKSQYNTTVASLKNFSIKTVWKTELNQLKNVNVANTFGETNGLTVALNSDSATTANSAWKNGNVSLSTDTITLLSGQSVGSSTQLSQLAMIEASDAASPDCLNAVGSYRAARAAGSTAEQNLQQQQLDGSDDTNSEVQQLNLLNAGQVQQMNDQQAQGSLHTCIATQLAIQNMQQRNAAARDLNTAAYIRQQNLTAPKHPENQGDTWNNYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X9</accession>
    <name>E8X7X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein TrbG/VirB9/CagX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4633</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573282.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71563">
        <property type="protein sequence ID" value="ADW71563"/>
        <property type="gene ID" value="AciX9_4633"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4633"/>
    <dbReference type="HOGENOM" id="CLU_087514_0_0_0"/>
    <dbReference type="OrthoDB" id="1251301at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010258">
        <property type="entry name" value="Conjugal_tfr_TrbG/VirB9/CagX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038161">
        <property type="entry name" value="VirB9/CagX/TrbG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03524">
        <property type="entry name" value="CagX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230875" evidence="2">
        <location>
            <begin position="24"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="279" mass="30816" checksum="D698581A9AE0192A" modified="2011-04-05" version="1">MKTSKNILTALLLTGSAAIPALSQTVTTKPRIQANAPRSIVIAETEAPPVIRTGLLQSTLILLPAEEKVATVFGGDTSSWVFDGGHVASRFISIKPKVANSTTDVHIVSDHGNEYTLQLREVSADADPHYDSKVFISPGDQAGKEKLVTLPVFVPAAELDKAKREAAEAEAKEATERKQAEAKAESYRSQYPGQLHFDYAWDRKKADGLGLQEVWRDDKFTYLRGKFQETPVLYELKDGKGSLINWSYNDGLYTVDKTMLQGYLTIGKQRVDFKRQGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y8</accession>
    <name>E8X7Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573291.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71572">
        <property type="protein sequence ID" value="ADW71572"/>
        <property type="gene ID" value="AciX9_4642"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4642"/>
    <dbReference type="HOGENOM" id="CLU_037612_5_6_0"/>
    <dbReference type="OMA" id="RRLAVFQ"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="197" mass="21502" checksum="F6305492E43C262D" modified="2011-04-05" version="1">MIITIASFKGGVGKTTTAVHLATYLAGKAPTLLLDGDENRSATAWAQRGSLPFRVADERQAAKLGREFEHLVIDTQARPNQEDLKALAEGCDLLIIPSTPDVLALDALILTVEALKGLRNVSYRVLLTIVHPRPNKDGDEARATLEELKIPTFKGCVHRLIAFQKAALKGVPVNQADDARAWSAWNDYEQIGEQILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X804</accession>
    <name>E8X804_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase HEAT domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4658</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573307.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71588">
        <property type="protein sequence ID" value="ADW71588"/>
        <property type="gene ID" value="AciX9_4658"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4658"/>
    <dbReference type="HOGENOM" id="CLU_423215_0_0_0"/>
    <dbReference type="OrthoDB" id="1113913at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233783" evidence="1">
        <location>
            <begin position="22"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="647" mass="69110" checksum="73F94A9F609E66B0" modified="2011-04-05" version="1">MGASKALLCLCLTSFGLLAQAQVDNVQLQIVRLQDADPVVRTIAVIALGQFKDARAIDPLLASLKDPDSLVRMIAASSLSGFKEPREVPPLIAALSDPNGDVSMAAGFTLGDLQDPRAIPAMISALADHRGGGMSLTRMGHAAVPALIEALHDSNPKVRGGVAEALATLKDSAAVTPLLAAIHDPDAAVRRSVVVALSSFHDSRTADTVMAETKDPDATVREVVVRLLDRMDDPRAFAALLAATHDPVRAVQLSAWGALGQSGDPRAVAPLIDALKSDDAGIRANAIGWLMRFHQPEVVPVLMAEYRSIPDRSTRLRALEGLGIPGDRAVTDFLIAALADGDSGVRMTAAKSLGKTQDVRAVKALSAGLVSPSNNDKQPFYQALAHMGPAAYEWLLEQVHDSRSCPQAVGYLAATHDPRAVTELVALLHTPYSGPDAPGLVGMATRLDMERAAARAHEVTGTCFFAAAKVLAALHDERVIAPLMESLKTPHSGRGQVPDLLRVFGPAVVEPMIALFHDADQETRRLAALTLAFVPEARLDAALKKKRDTALRTALRELNLAVLAGDYRYYVVLGELGSEDSLARALKRFDNTMEAQEMAETFLTCGDVLLEDAGFAWGRERHFHMTPSSYGVVWGRGVEQARGDTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X836</accession>
    <name>E8X836_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AraC family transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4693</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71620">
        <property type="protein sequence ID" value="ADW71620"/>
        <property type="gene ID" value="AciX9_4693"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4693"/>
    <dbReference type="HOGENOM" id="CLU_066193_5_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23299" checksum="635A9EF3285761D8" modified="2011-04-05" version="1">MQESGYAVSPPRGVMKRAQAGVSGAFTHRRVKPPPRLSHCLEHFWMVQWDIRSGSPQVQETLPHPNVHLAFTRSFDERVSSSTVAEVHGVKSSKFSRYLEGQAWVFGVKFRPGGFRCFSDQSASVLTERVVPAARVFGAGLQCIAERLSPSNAVDQISSFLEEFAITRDPQAEFAGQLTDLIAADSTLTKVSAFAKRAGTSVRSLERLFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X847</accession>
    <name>E8X847_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4704</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71631">
        <property type="protein sequence ID" value="ADW71631"/>
        <property type="gene ID" value="AciX9_4704"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4704"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_0_0"/>
    <dbReference type="OMA" id="HMAESHE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="13279" checksum="776C8DCB2EDCA30F" modified="2011-04-05" version="1">MATNKAPAKKIVAPVAAKTSAAPAKKTSTTKKMTKSELVKLVAEKMELSLKQSAAFFDLLASTAIQETKKNGEFTIPGLGKLVKAQRAARIGRNPQTGESIKIKAKTAVKFRVAKAAKDMIAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG5</accession>
    <name>E8WVG5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1353</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579736.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1353"/>
    <dbReference type="EnsemblBacteria" id="ADW68413">
        <property type="protein sequence ID" value="ADW68413"/>
        <property type="gene ID" value="AciX9_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1353"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_15_1_0"/>
    <dbReference type="OMA" id="VYIDANF"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="242"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="454" mass="48755" checksum="3C4115CC9C090D7C" modified="2011-04-05" version="1">MADTEQQQESQQGQQTDHQQPEQKSAPASAPAKPAAPEETPARKTGRRVFIFGVLILLVLGAAFWYWRSTFSEDTDDAQVDGDIYQISSRITGQVIHVYAEDNTKVNKGDLLIEIDPKDYQVALEQAQAALASAQADYTNANVNVPITSTTSNTQVSTSNSDVRGSASSVTQAQQQAAAAAARVEQEQANAIKAAKDVERYTPLVEKDVISRQQYDAAIASSRASSAAVLEAENNLVAQQSAVTTAQQKLDQSRAQAMQAAKNGPQQVKAQQARAQSMLAQVKSAQAKVDQALLNLSYTRVVAPSSGVINKKSVVVGANLAVGQDLLTIIPLTNLWVTANFKETQLKGMHRCQEVGIKVDALGGREFSGKVTQIGGATGSRLSLFPPENATGNYVKVVQRIPVRIDFTNLDKENGDYALRPGFSVTPDVTIKGKDDNKNTSDCEKGLPEQQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH4</accession>
    <name>E8WVH4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1362</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579745.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1362"/>
    <dbReference type="EnsemblBacteria" id="ADW68422">
        <property type="protein sequence ID" value="ADW68422"/>
        <property type="gene ID" value="AciX9_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1362"/>
    <dbReference type="eggNOG" id="ENOG5033773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2219407_0_0_0"/>
    <dbReference type="OMA" id="LESIWAK"/>
    <dbReference type="OrthoDB" id="1999919at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="12623" checksum="32D2FA24B6C62F57" modified="2011-04-05" version="1">MSAPWPPPPDLHSIQELVRAADPEKHLAEGAPADEYEPEEQSIFEAIHHLSTADLLVPNILPPIEHIWTKSFSLNAEDLAERRPALLSLAKEIERFFGPESKPRTRAEIIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK6</accession>
    <name>E8WVK6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Minor extracellular protease VpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69535">
        <property type="protein sequence ID" value="ADW69535"/>
        <property type="gene ID" value="AciX9_2503"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2503"/>
    <dbReference type="HOGENOM" id="CLU_215851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="5352" checksum="10AF77594031445A" modified="2011-04-05" version="1">MPFDGGLKSPSNPNGNGNGNGNGKSNGNRNGNGKSKSNGNRNGKYGGSELRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP0</accession>
    <name>E8WVP0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2539</name>
        <name evidence="3" type="ordered locus">AciX9_3661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69569">
        <property type="protein sequence ID" value="ADW69569"/>
        <property type="gene ID" value="AciX9_2539"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70662">
        <property type="protein sequence ID" value="ADW70662"/>
        <property type="gene ID" value="AciX9_3661"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2539"/>
    <dbReference type="KEGG" id="acm:AciX9_3661"/>
    <dbReference type="HOGENOM" id="CLU_3234230_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="43" mass="4660" checksum="FDBD821A1DF09D43" modified="2011-04-05" version="1">MSLRLRTNPSQNKQSTAPPAEKLGRRLKSHTDIVKSAACAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV4</accession>
    <name>E8WVV4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3712</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582022.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3712"/>
    <dbReference type="EnsemblBacteria" id="ADW70713">
        <property type="protein sequence ID" value="ADW70713"/>
        <property type="gene ID" value="AciX9_3712"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3712"/>
    <dbReference type="eggNOG" id="COG0676">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048345_4_0_0"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="710313at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="32133" checksum="26ECB628FBD2B939" modified="2011-04-05" version="1">MNLTELNDHFGLSGVLTFEDHNGLTRLQVKTPACTATVYLHGAHLTHWQPTGAQPVLFLSDRSDFAPDKAIRGGIPVCFPWFGPRAGGKPGPSHGFARIQPWEVAFAALSGENVHLTLTLGPTALSRSLGFDGFRVAYEMVLGKKLTLRLTVANYGEGMLKYEEALHTYFSIGEVRRTTIAGLESALFVDKTDGLKEKETPPEALILSGQTDRVFPENVSSTTIGDGPRTITINKSNSATTVVWNPWTEGSVTLKDLRPDAWPGFVCVETANTGEDAITLAPNDAHTMQAEITLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW09</accession>
    <name>E8WW09_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0241</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578643.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0241"/>
    <dbReference type="EnsemblBacteria" id="ADW67315">
        <property type="protein sequence ID" value="ADW67315"/>
        <property type="gene ID" value="AciX9_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0241"/>
    <dbReference type="eggNOG" id="ENOG5031RMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091313_1_0_0"/>
    <dbReference type="OMA" id="GTETHDR"/>
    <dbReference type="OrthoDB" id="1524864at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="217" mass="23397" checksum="5B1D657B32E33477" modified="2011-04-05" version="1">MTTQYDSGRRGSTSFFTFVFALILGAAALVFFLRQATTGLSGRIATMISGRTTAFDTSVPVVVEKIQRLSRLETVVYSVDTVVEGAHASPILPDILAGDRILLVVHGQSIAGIDLSKLKPEDVRIDANNPRSIHVNLPASEVFITSLDNVHTRVYSRTTGLLVPVDQNLESDTRAKAQQQLQAGALSDGILDAARKNARATITTLLYGLGFQQVEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW26</accession>
    <name>E8WW26_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0258</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0258"/>
    <dbReference type="EnsemblBacteria" id="ADW67332">
        <property type="protein sequence ID" value="ADW67332"/>
        <property type="gene ID" value="AciX9_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0258"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_0"/>
    <dbReference type="OMA" id="PLVPYNA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="473" mass="51959" checksum="455036337C8AED85" modified="2011-04-05" version="1">MSTPGSTLTSQEVVDIVRTTNYGTWRFQKSWNPLHIVDAKDCTITDGNGKQYLDFSSQLMCSNLGHKNPAVIASIAAQAEELAYAMPGYATTCRAELSKLLLEILPPSLNKFFFTTSGTDANEAAFKIARMYTGKTKIIARYRSYHGSTAGSIAATGDPRRWAMEPRGKQQGVIFAPEVNCYRCPIKHTYPACGIACADYLEHMIRNESDVAAVLVEPIVGTNGVLVPPEEYMPKLRKICDEYGVLLIADEVMTGWGRTGKWFAMEHWGVVPDILTTAKGITSAYVPLGLCATSEKIGAFFQDHYFSHGHTYEAHPMTLAPAVATINEMRRLNLVDRSAELAPYVEAKLRELKAKHPSVGDVRGKGLFWAVELVKNQTTKEPFNTYSDKVSGTPLLVDQIAGKCMADGVIIQAWVSHFVVAPPLIVTREEIDRGIATLDKHLALADALVEPDRAREVSFDFNLVTSTSATSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW64</accession>
    <name>E8WW64_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S9B dipeptidylpeptidase IV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0298</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0298"/>
    <dbReference type="ESTHER" id="acism-e8ww64">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67370">
        <property type="protein sequence ID" value="ADW67370"/>
        <property type="gene ID" value="AciX9_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0298"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_3_1_0"/>
    <dbReference type="OMA" id="MYGERYM"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230365" evidence="1">
        <location>
            <begin position="20"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="169"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="576"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="810" mass="90179" checksum="3DED9A43597C688C" modified="2011-04-05" version="1">MHPLKHLSAALLTCTLTFAAAQQAPRVYTDADYAQAEKFMPYNTNPLVMHAVENPTWLADGRFWYRDTGAKGNTFMLVDPAKSAKAPAFDQAKLASAMNALALSKKTISPDHLPITNFELKDADKTVLTTLAGKRISCDLAGDGVCKELDPKEAGAPKTGRRGKAMGGVDVSPDGKKAAFIRDWNLWLRDLPTGKETQLTTDGIPNYGYATDNAGWSHSDNPILVWSPDSKHIATFQQDQRKTGELYLTNVTNGHPTLTTLKYPLVGDKDVTMIERVVINLEGKDSDKSKLVRLKMAPDQHRSTLCDDISCRGGSGWDDVQWSSDSKNLAFVSTSRDHRQEWMRIANPATGEIREVMGETAPKFFESGNDKVNWHYLAATNELLWFSERDGWGHLYLYDTNTGKLKTQITHGNWNVTQVLVVDEKARVIYFRGVGKDPNEDPYFQKYYRVDFTGDNLALLTPERGDHTVTPSPDNHYFVDTWSTPTDPQVTVVRDFTGKIAVSVAHEDITRLKATGWIPPVQIMVKARDNDTNIYGLLFRPTNFTTDGHYPIINHVYPGPQTGSCGSRSFSAAHGDMQSLAELGFIVVCIDGMGTPYRSKAFHEFYAHDLGDDTIPDQIAGMKDLSTRYPWIDMDKIGIYGHSGGGNATASAMFHFPDFFKVGIAESGNHDNRNYEDDWAEKWAGLEIKNPDGTSNYDSQANQNWAKNLKGHLLLAHGTMDDNVPPTNTLLVVDALIKANKDFDLLMIPNVHHGYAEASQYMTRRRWDYFIRYLAGATPPHEYKMKDYAAVQAAMSGNGPSDNETADPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW73</accession>
    <name>E8WW73_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1397</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579778.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1397"/>
    <dbReference type="EnsemblBacteria" id="ADW68456">
        <property type="protein sequence ID" value="ADW68456"/>
        <property type="gene ID" value="AciX9_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1397"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_7_1_0"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="323"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="408" mass="40299" checksum="6A1C5C4CE7955088" modified="2011-04-05" version="1">MSLGVLNNIAAIYAQNNLNNTQASLQNTLTQLSSGSRINSGSDDAAGLAVADGLAANESALTQSAANASDGIGLLQTADGALSQVTNLLNRAVTLSTEAANGTLNSNQVSSANQEYQNILSEIGNIGVTTNFNGRSVFTSTAKTVFVSDGTVSGANVYSDVVGTLAKGGVGETAPVGAGIAITNPTPTASTLTAGSVATFGALAATTDSVGGTISVAVGTGGTAVVSTIAKGTALSDVVSQLNAQYNAANNGVTASLVSGKLTITGPQDAANTTAGTNTLVVTGTALTDYAQATSTAGPAAGIDFTQSTVSTLTQATAQTVLTTVTSAIAAVAYQRGIIGADVNQLTAASGVASTESENLTAAESNIRETNYGQATSDLAKYEVLSQTGISALAQANSVQQEVLKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW85</accession>
    <name>E8WW85_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1410</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579790.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1410"/>
    <dbReference type="EnsemblBacteria" id="ADW68468">
        <property type="protein sequence ID" value="ADW68468"/>
        <property type="gene ID" value="AciX9_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1410"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_0_0"/>
    <dbReference type="OMA" id="AQEDYKM"/>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="365" mass="39505" checksum="7633AC70A5CD8E1E" modified="2011-04-05" version="1">MTKAPIHPLEKILAERIAIIDGAMGTTIRTYGMTEADMRGERFKNHNKDLQNNGDLFSLTQPKMIEDIHRRFLEAGADIIETNTFGATSITQSEFFVDDPREHGGRKDPAFYQNIIEDKFLNDLAWEVNETSARQCRAWADRVANDTGRQRFVAGAIGPLTVSLSNSPDADDAGFRVVTFDQVKAAYIHQIRALIAGGSDLLLVETIFDSLNAKAALVAIREVFDEDKVDLPIMISAAVGRGGETLISAQTTEAFWNAVKHVKPLSVGLNCSLGPDLMYPFLSELSAKADVAISCYPNAGLPNPLSETGFDLGPPDMARFLGGFAQDGLINIAGGCCGNTPEHIAAIAKALEGKAPRTLLREVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA2</accession>
    <name>E8WWA2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1427</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579807.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1427"/>
    <dbReference type="EnsemblBacteria" id="ADW68485">
        <property type="protein sequence ID" value="ADW68485"/>
        <property type="gene ID" value="AciX9_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1427"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="EFIYIIG"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24219" checksum="270196F8860F7E72" modified="2011-04-05" version="1">MSVAIRAEGLRKAYSGVTSGAGEIELFRGLDLSVNAGEMIAIVGQSGAGKSSLLHLLAALDRPTAGEVWVGETRLSTLTSKGASEFRNREIGYVWQFHYLMPEFTAVENVAMPLLARGLGRTEALKRAKVWLAEVGLGDRAEHRSGELSGGEQQRVSLARALVTEPKALLADEPTGDLDGRTSEAVFGLLQGLHKAHGLTSVLVTHNLEFAARCDRMLRLSDGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ0</accession>
    <name>E8WWQ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosine/AMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0306</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578706.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0306"/>
    <dbReference type="EnsemblBacteria" id="ADW67378">
        <property type="protein sequence ID" value="ADW67378"/>
        <property type="gene ID" value="AciX9_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0306"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573569_0_0_0"/>
    <dbReference type="OMA" id="AALQWKL"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230003" evidence="3">
        <location>
            <begin position="20"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="269"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="548" mass="59847" checksum="89DE1DFE13E5FA64" modified="2011-04-05" version="1">MRESLCILLASGLAVSAFAQPAHHIAPANQSERRATQAFESAKALSPLALHSFLERMPKGADLHMHLSGAIYAETFIKDAAEDNLCVDPIKLAFAKSIGTDTPNPTCAPDNVLAATAFKNQHLYDALVDSFSMRAYVPTPGHTGHDQFFDTFEKFGGIAKTHKGEWLDEVASRAAAQNEQYLEIMETPTFSKAAALGYKLGWPTAPTPRIVTTAATSVPDDTTGTLPAELADLRDKLLASGLKDEVVTDRAEFAKALADRRQIEHCGTPTAAPACAVQIRFLYQVLRAFPAQQVFAQTLLAFEVADAELASGPNANVVGLNFVQPEDNYMAMSEYHRQMLMLDYLHSVYPRVHISLHAGELAPGMVPPAGLSFHIRQAVELGHAERIGHGVDVMYETDSKGLLKELADKHIMVEINLTSNDGILGVSTNYHSLPAYRAAHVPTAFSTDDEGVSRIDLTHEYARAVKDFNLTYPDLKRSARTSLEHSFLPGPSLWAHPDDFTTLNFACIGQAIGSPTTTFVCGSFLKSSPRAAQQWELEHRFQLFESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT7</accession>
    <name>E8WWT7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0343</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578743.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0343"/>
    <dbReference type="EnsemblBacteria" id="ADW67415">
        <property type="protein sequence ID" value="ADW67415"/>
        <property type="gene ID" value="AciX9_0343"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0343"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023239_0_0_0"/>
    <dbReference type="OMA" id="QTQPDYF"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233930" evidence="2">
        <location>
            <begin position="35"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="659" mass="69943" checksum="89F0FB05F01DAD14" modified="2011-04-05" version="1">MTSGRGFRFTVGAVAFALSTFTPVLCSGQSAAMAAPAAPHATAPSFVYSNPRTGSDDPRVGLKGGLYDAQEAILGMQRLVSLPKPAGFEPDVAAIKAADATPPPAPPAPGAPRVRGARGPSYGGTNSDIAFGATHLFVGNYNGVNFYDISNPAQTKLITSVVCPGGQGDVSVYGHLLFMSVEAANGRLDCGTQGMPTAPPPTPEQEAAMMAPPVAGAPRPARPQDPASHDREKGVRIFDISDIKNPKQVADVQTCRGSHTHTLLVDPKDKDNIYVYVSGSAGVRPAEELGGCTGGDPNIDPDTALFTIVVIKVPLAHPELAKVVSSPRIFSDPETGKMDALWKGGNHGEGTQTTSATRGCHDITVYSAIGLAAGACSGNGILLDIKDPVHPKRIDAVTDPNYAFWHSANFSNDGTKVMFTDEWGGGGQPRCRESDPMNWGADAIFRISKDDKLQLASYYKMPAPQTEKENCVAHNGSMIPIPGRDIEVQSWYQGGISIMDYTDASHPFEIGYFDRGPVDDSRPAMGGQWSTYYYNGYIYGSEIARGVDVFKLVPSKYITQAEIDAAAQVNLPELNVQNQPKIVWPSTAVTARAYVDQLARDNSLTAAQVSSINAELAKSKSAKLKAMAKGLDKDAATAKTPKDAERMHELAKIMSQSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ4</accession>
    <name>E8WWZ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1502</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579875.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1502"/>
    <dbReference type="EnsemblBacteria" id="ADW68555">
        <property type="protein sequence ID" value="ADW68555"/>
        <property type="gene ID" value="AciX9_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1502"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_0"/>
    <dbReference type="OMA" id="PPAHGNW"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="559" mass="60938" checksum="F568DCDA0A4276CD" modified="2011-04-05" version="1">MKIFRTDHRTIGLSYLVLALIAVAIGTFLSLLMRVHLVWPNRVLPLFGPIKPEDYLALVTIHGTLMLFFVLTTAPQAGFGNLILPAQIGARSMAFPLLNALGFCFTATALLTLLASSFVQGGAAISGWTAYPPLSAVASAGPGQGLGMDLWLASIGLFGIGSIFSSVNTLTTIVTRRCEGMTWERLPLTVWAWFTAAILSVIAFSVLLAALTLLFMDRHAGTSFFLPAGDLVNGTLHRSGNGSPLLWLHLFWFFGHPEVYIAILPGMGLTSMLLANFSRRRVFAYRTMITTTLLIGFLGILVWGHHMFVAGLNPFAGTAFSISTMAIALPSAAKVLSWLATTWQSRPNYSTPMLFSLGFVSLFIAGGLTGPILAQPILDQYLHNTYFVVAHFHLIMAMAGIFGLFAATYYWFPLVCGRLMNERLGRWHFWLTLVGAYATFLPMHLAGLMGNPRHYSQLNGIQNAATTLLARAMPIQKHVTYAAVFLIASQLIFLFNLARSLRCGAPAPENPWGATTLEWIPASLASNAQISVHCGPCEYDERVGSQSFQPQWAEAAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ6</accession>
    <name>E8WWZ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579877.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1504"/>
    <dbReference type="EnsemblBacteria" id="ADW68557">
        <property type="protein sequence ID" value="ADW68557"/>
        <property type="gene ID" value="AciX9_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1504"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942546_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233937" evidence="1">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="295" mass="31159" checksum="9A16A17CE1FEE94D" modified="2011-04-05" version="1">MKLLTILLAAATLASAQEAPKPGPLAWSFAELLSRSSNGHSPTQDEIAAAGQVTANAAALREALPLILKALENPDEPVRAYALTTLVSLEAPADPATPAAPIAYKSEFQKILTPAIPKIAAHLTDESQGDRILTAAILGGFSPDPPASIYPPLFAYLKRDDGVGTVGQAVVEDILQLGPIHDDAAAAIISYLHRPDQTSDSRSNLVEAIATHPFQSQSVNKVLLGYLDSDDPSLRARLILSLPQLDLAPDVFTETRERVTQLTANDQESLAVVNAAKSVATCWTAVKMASGCPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX27</accession>
    <name>E8WX27_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1535</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579907.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1535"/>
    <dbReference type="EnsemblBacteria" id="ADW68588">
        <property type="protein sequence ID" value="ADW68588"/>
        <property type="gene ID" value="AciX9_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1535"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_0"/>
    <dbReference type="OMA" id="MGFNITR"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="427" mass="46568" checksum="CB26384F14A760FF" modified="2011-04-05" version="1">MIEREPPNRVSDSQPFLKRIFRAFRYRDFRIMWLGACVSTIGTFVQQFAQSWLVYDLTKDPFYLGLDLFLGQLPIMLFSLFGGVFADRLDRKKMLLSSQYIQMVCAFVLATLFATHTVHVWHILTLSFLVGVGQSFGGPAYSALLPTLVAQEDLANAISMNSIQFNLARIIGPTLGGLAYTVFGATWCFALNGVSYVAVILSLLLIKVHFTAPKTQISVMKSMKEGITFIREREGLTPLVVLAFCTTLFGFSLTGFLPVIVRTVFHRGPGTYELLLIFSGAGSICGALMVAAMEKFKGQGRLAVLALIVLGSATSAFSISRSFPLSCALIFLAGMAVMASASLMLSLVQVIVVDSMRGRVMSVYNLAFRAGIPLGALVLGKLIPFIGVTTAVASFGLALIIVAGYFLLVMRKTPTFRRQPHTGLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF2</accession>
    <name>E8WXF2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0413</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578813.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67485">
        <property type="protein sequence ID" value="ADW67485"/>
        <property type="gene ID" value="AciX9_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0413"/>
    <dbReference type="HOGENOM" id="CLU_2273409_0_0_0"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11109" checksum="D25CE44650CF60FC" modified="2011-04-05" version="1">MGVATAERSAKASFREPDFSDEQIREVAGNDAAAIAQWADTVAKERGIRVRPRPNDAFIKAVSRLSDGVVDLDPVEELLVELSRAGVISSFQRGLLQVHYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS1</accession>
    <name>E8WXS1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ordered locus">AciX9_2742</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2742"/>
    <dbReference type="EnsemblBacteria" id="ADW69766">
        <property type="protein sequence ID" value="ADW69766"/>
        <property type="gene ID" value="AciX9_2742"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2742"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_0"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="46"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="548"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="404"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="428"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="662" mass="73100" checksum="07DD1BF516D7DB53" modified="2011-04-05" version="1">MSSSSNSATESTTVHTNMHSFLREDRVFAPPAEFAAKAHVTSLDDYEAMYKRSVDDPEGFWSDAANELEWFTPFTSVVQGEMGSARWFEGGRLNLCHNCVDRHALGVRRDKVAIVWEGEPGEVKRLTYGDLLEQVQVFGNVLKSLGVKKGDRVAIYMGMCPELAIALLACARVGAVHNVIFGGFAAHALVDRINDSECKVVLTQDTSYRRGGEVKLKAIVDEALEKCPGVESVLVHRRSGTAVAMKEGRDLWLDEESAKFAGQACVAEAMESEDPLYILYTSGTTGKPKGLVHTTGGYSVGTYLTSKYNFDLREEDVYWCTADIGWVTGHSYVVYGPLQNGATVLMYEGAPNHPQPDRFWKLIDDHKVTVFYTAPTAIRSFIKWGGEWLKPYSLASLRLLGTVGEPINPESWMWYYREIGHEKCPIVDTWWQTETGAHMIAPVPGAVATKPGSATRPFFGIVPEIVTKEGEPVPAGQGGLLVIRKPWPSMARTIYGDAERYKQAYFSEIPGAYFTGDGARCDADGYYWLMGRVDDVINVSGHRLGTMEIESALVAHPKVAEAAVVGRPDEMKGQAISAFVSLEEGHEPSDELKNELRQWVAKEIGALARPDDLRFTQSLPKTRSGKIMRRLLRELATTGTVTGDTTTLEDFNVIASLRGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY72</accession>
    <name>E8WY72_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hopanoid biosynthesis associated radical SAM protein HpnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1647</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580018.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1647"/>
    <dbReference type="EnsemblBacteria" id="ADW68699">
        <property type="protein sequence ID" value="ADW68699"/>
        <property type="gene ID" value="AciX9_1647"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1647"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_2_0"/>
    <dbReference type="OMA" id="YRQFYFR"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017834">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00404">
        <property type="entry name" value="hopanetetrol_cyclitol_ether_sy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03471">
        <property type="entry name" value="HpnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="198"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="496" mass="56616" checksum="A779FDCB7A765334" modified="2011-04-05" version="1">MNKPLKTLLLNPPSFENFDGGASSRWPAVREIESYWYPVWLAYPAGLLEGSRLLDAPPHHVSADETIEIAKSYEFLVLFTSTVGWAGDHALAQAIKKANPTIKIAFVGPPVTTDPYRALNECSAIDFVCRREFDFTVVEFANHKPINEILGLTYRNPEGGFFDNPDRPQVEKLDKPDMPWATEIYARDMDVTKYNVPFLLHPYVSLYSTRGCPAQCTFCLWPQTLSGHAWRKRSTDDVAAEMANAKKLFPHVKEFFFDDDTFNIQKERTIELCAKLKPLNITWSCTSRVTTHRETLKAMKEAGCRLLIVGFESGDPQILKNIKKGATVERAREFVKDCHDLGLIIHADFILGLPGETKQSIRNTIDFAKSLDCETIQVSIAHAYPGTEFYEFAEKNGFITNHKMDDDAGHQMAHIEYPGLPVEYVMEMVHKFYDEYYFRPKAAFRVVWKAIVNRDVPRLYVEAKSFMKLRSQRNKASRKMKEENALKAQESVSMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF3</accession>
    <name>E8WYF3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2836</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581174.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2836"/>
    <dbReference type="EnsemblBacteria" id="ADW69859">
        <property type="protein sequence ID" value="ADW69859"/>
        <property type="gene ID" value="AciX9_2836"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2836"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475583_0_0_0"/>
    <dbReference type="OMA" id="EFIALAF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234166" evidence="3">
        <location>
            <begin position="27"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="619" mass="66733" checksum="DA4E4041364613D0" modified="2011-04-05" version="1">MAPKRTALNSLPALALTCFLAIPAFAQDAPVPKAQAPADQRAYKAARALTDPTQKLAALRQFTHDYPKSNRVARANSTIFTLLLLSGPQHEPEIKAEAKSQVKHAGKGDSRWSKENEVAFDLAEAEPNGIDLPLAEKWAKDSVKHQTEPLFIASLTADYVKYKVPVPKPAEIHDYFAHQHAGSLQTLADVYFHEGKLPEANKTLAEAYALNPKDDAVNSLMGQIAFAQHKDAEALDDFERAQLFGGLKPSLQQQMMTLYRQANNGSDATFLTAQDTRYKQLFPAPFEPTAHKPTPGGHTVLLELFTGSACGPCVGMDLAVEGLLETYPRDEFIALAFDQHIPDPDPLSNPDSIARASLYGIASTPTVVLDGKPLEPSGGPRSTSEKFYKTFVTKLDPLTAAPSPIALKLTADRTAAGQIEAHATVTLPDLKALAEQIAIDPAPAPPKKPAETTATAAAAKAPDSKKKPEKNAAAPPPPPPTPVAAPVVPADPKLTLNFALVEDDIRYPGENGVRFHRMVVRSLAKPSDAAFPIDPSATATLDATFDLQQIAHTNSDYLTAYAKHNDRFEHVEFLSTDTKIQPTHLAIVAWVQDATTHRVLQSAYIPLTASNLTATTGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG4</accession>
    <name>E8WYG4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2847</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581185.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2847"/>
    <dbReference type="EnsemblBacteria" id="ADW69870">
        <property type="protein sequence ID" value="ADW69870"/>
        <property type="gene ID" value="AciX9_2847"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2847"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024745_0_0_0"/>
    <dbReference type="OMA" id="MHRHRRC"/>
    <dbReference type="OrthoDB" id="809519at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="491" mass="54048" checksum="ABFDCECDC5B0EA9A" modified="2011-04-05" version="1">MSATKNETDVYAIHGADPEVLAYAMAKYSRSGLTMKESLAEISAQRAEQFLNTFYFQYGHRSIADLAHIPMAIERLSLLAAIALVDEQRWDGQERSTRYQDFRKSGWYTPAVGDQTASYTAAIEALFGAYERIGAGMLEALQGAIARPAEMKEEAYVRTLKARAFDVARYLLPLATNTSLGQIVNARTLETQVSRLLTSEFGEIRGLGERLRAAASEAAWNPNEGAREVKVAPTLVKYAVPNAYQAETAGLLRAAVAELMGGAAIAKAPVVDLVEEGKSLEVELATSLLYPHCHYSYRQVRDRVAGLSGSGVMEVIEMGTRLRGRHDELLRAYSSGGGLRFDILMDVGGFRDMHRHRRCVQLLQGFTDVHGYEDPGCPGQPTLEEAGLAGVYKGAMDAAFGAYEDLKVSGCEEAGESAQYLLPLGTRCRAMFKMDFAEALYISELRSGVAGHFSYRRVAWEMYLAVKKAHPGLAGLFRIEDVWEPVDLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL7</accession>
    <name>E8WYL7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0543</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67615">
        <property type="protein sequence ID" value="ADW67615"/>
        <property type="gene ID" value="AciX9_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0543"/>
    <dbReference type="eggNOG" id="ENOG502Z9TY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766760_0_0_0"/>
    <dbReference type="OMA" id="ANCANFA"/>
    <dbReference type="OrthoDB" id="1130736at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234170" evidence="2">
        <location>
            <begin position="31"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="38364" checksum="D983B6DEB5ADD81D" modified="2011-04-05" version="1">MFRFRLQSIRPLMCAYVVATVFAVCNQAHASLTVLVGEPFGPFGTMMPVGHAAIYLDHVCAAGPLKLRMCQPGEPEGVVIARYHQIGNLDWIATPVMQFLYATDSPQNIPSYVTPEIAWDMRQTYRRRYLADIVPDGKEKAKVTDEWWESAGVAFNRKLWGYQLATTREQDEAFVDAMNDRINVHRYHLSTANCANFAGDVVNAYFPGAVHHDIIADYGWLTPKQVARSIAAYGNAHPELNPRILEIPQIPGTLRRSRPVRGAGEALLKTKRYLATLIVIQPEIPLISTILYLDRGRWQIGQGAEPVGPDVFAPRTSVAGSAADPALTASPTTGSETMDQQMNQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM6</accession>
    <name>E8WYM6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0552</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578952.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0552"/>
    <dbReference type="EnsemblBacteria" id="ADW67624">
        <property type="protein sequence ID" value="ADW67624"/>
        <property type="gene ID" value="AciX9_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0552"/>
    <dbReference type="eggNOG" id="ENOG50315Y9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393125_0_0_0"/>
    <dbReference type="OMA" id="MEERDFF"/>
    <dbReference type="OrthoDB" id="2016937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="10691" checksum="6C87B516669538CA" modified="2011-04-05" version="1">MEERDFFDERPETRNHLMTCPHCGQQAEYQLNWLVRRKKAQLGRGADERDRARFAKAQSYMVRRDDLVGCKNIRCRKRFDVAGIQSVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT5</accession>
    <name>E8WYT5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1723</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580090.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1723"/>
    <dbReference type="EnsemblBacteria" id="ADW68771">
        <property type="protein sequence ID" value="ADW68771"/>
        <property type="gene ID" value="AciX9_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1723"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_3_0"/>
    <dbReference type="OMA" id="WYFPSIG"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="27263" checksum="D6C9BE35A9F4E65E" modified="2011-04-05" version="1">MATSVQTWNTTAYAANGRFVATMATAIVDLLNPQPGEHILDLGCGDGALTTQLAASGALLTGVDASDTMVAAARARGLTIDHHRAENLPYETQFDAIFSNAALHWINLALQPAALAAIRRALKPTGRFVAEMGGQGNIAAIRTALSAVLAPYNLDSEALAASFFPSPAHYQSLLEAAGFAVQSVTLHPRPTPLPGGPDGMATWLQTFRNGVLDHVPAKHRPKALADTVALLTPILQDPLTHNWTADYVRLRLHATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW6</accession>
    <name>E8WYW6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1754</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580121.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1754"/>
    <dbReference type="EnsemblBacteria" id="ADW68802">
        <property type="protein sequence ID" value="ADW68802"/>
        <property type="gene ID" value="AciX9_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1754"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="OMA" id="QHGKIDN"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="26758" checksum="C8B17B27F9A01C56" modified="2011-04-05" version="1">MPSPSTLPQSFRLDGKVALITGSASGLGAAIATALAQAGATVACHGNRRPATETAEAIGGQAADFRADLSSTTGPEDLFAQVHAKFGKVDILVNNAGTIHRDAAEDTTLESWQQVLQVNLTSVFQLSQFVAKDLIARSAPGKILNIASLLSFQGGIRVPAYAASKGGVAQLTKALANEWAPKNIQVNAIAPGYFATTNTEALQADETRNRQILERIPAGRWGQPEDLAGAALFLTSRASDYVTGTVLTVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ02</accession>
    <name>E8WZ02_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2894</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581232.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2894"/>
    <dbReference type="EnsemblBacteria" id="ADW69917">
        <property type="protein sequence ID" value="ADW69917"/>
        <property type="gene ID" value="AciX9_2894"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2894"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060750_0_0_0"/>
    <dbReference type="OMA" id="RENVHFA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="27770" checksum="DA09C6D20AED7BBF" modified="2011-04-05" version="1">MRMIVLGLLCGLALLSAGVVLHAHGGYAIQDRDSISTGTSAMHWTGTDDLGRDRTVRVAAALLLGLAGALLASALATTIAVGVGVTAAFAPEGIASLLMYASDLFLTLPWLFLLMMVRSSLPLTMPPLQSAGVTFLLLALLGWPAYVRVSYAGARNVRNAEWMLQGRASGLRTSQLATRHLLPHLRPLLLSQFLVCIPACLVAEANLGTLGLGISEPLPSWGSMLLSLQNSAVLASSHWVYLPIVLLVIVLLLLELLVFEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ46</accession>
    <name>E8WZ46_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ordered locus">AciX9_2938</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581276.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2938"/>
    <dbReference type="EnsemblBacteria" id="ADW69961">
        <property type="protein sequence ID" value="ADW69961"/>
        <property type="gene ID" value="AciX9_2938"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2938"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_0"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="17842" checksum="645193608C3FB96D" modified="2011-04-05" version="1">MAMRKKIDANRLNLKDEVVSINRVTKVVKGGKNMSFAALVVIGDPAEGVVGYGSGKAKEVPQAIRKGIEAAKKNLFKINMTETSIPHQVLGHFGAGSVMLKPAPEGTGIIAGKTVRAVMTSCGVQNVLTKSLGTKNPHNVVKATFDALIQLRDRAEVAALRGKLVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ68</accession>
    <name>E8WZ68_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578998.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67670">
        <property type="protein sequence ID" value="ADW67670"/>
        <property type="gene ID" value="AciX9_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0599"/>
    <dbReference type="HOGENOM" id="CLU_1737986_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230094" evidence="1">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16076" checksum="AC0904ED280B2547" modified="2011-04-05" version="1">MKLMAASFTLISAFILLGAAYSGYAENARINSTHTAGYADKFAPQASEGLTMDQAEEQGRLATAGLEGLVGLVLVFATVMLCGPAEKRVAAPTEYDLRGRRTPAVGSEEIRVAITASMIQRSRPQARLSPSGRVRIEELRAAKRDFARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD8</accession>
    <name>E8WZD8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1778</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1778"/>
    <dbReference type="EnsemblBacteria" id="ADW68826">
        <property type="protein sequence ID" value="ADW68826"/>
        <property type="gene ID" value="AciX9_1778"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1778"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936160_0_0_0"/>
    <dbReference type="OMA" id="WIDSEFE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14532">
        <property type="entry name" value="Sigma54_activ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="42"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="33164" checksum="D491EC698051D1D5" modified="2011-04-05" version="1">MNASQGGISFGWCHLFVITDGWWLPISRLGMWIDSEFEGLVFVGASEGAVRLRVQVSRMAPYYRTALVMGEVGVGKREVARELHRLSLVDGDFVCCPAGELTDEMVDRARMGTLYLYGLEALGMEEQDGLMGRLERMDRMMRARETEVRLVCSADGELKGMVAAGRMRQYLCVRISGMEIRVPALRERMEDLSALVGMVRVSDGAMEKLRGHGWPGNLAELTEMLRVSARNGVLREEDVPEFTVVERAQTAILRLDEVMRQHVADVLERCSGNKLKASELLGISRSTLYRMLDGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH6</accession>
    <name>E8WZH6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor GreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transcript cleavage factor GreB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">greB</name>
        <name evidence="7" type="ordered locus">AciX9_1817</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GreA/GreB family. GreB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580183.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1817"/>
    <dbReference type="EnsemblBacteria" id="ADW68864">
        <property type="protein sequence ID" value="ADW68864"/>
        <property type="gene ID" value="AciX9_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1817"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_3_0_0"/>
    <dbReference type="OMA" id="DQIFFGA"/>
    <dbReference type="OrthoDB" id="1591985at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00930">
        <property type="entry name" value="GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006358">
        <property type="entry name" value="Tscrpt_elong_fac_GreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01461">
        <property type="entry name" value="greB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22258" checksum="28F0093410570FAE" modified="2011-04-05" version="1">MRQGFTRRPKALEAAPPDQVKNYITPGGIERLKAERHFLLTKDRPAVVQVVAWAASNGDRSENADYQYSKRRLRQIDGRVRFLTKRIEAAEVIDPEAPRTGQRATRAFFGATVRYANAAGIVRVVSIVGTDEVNLDRNHISWASPLGRALMKAGEDDEVVLHAPGGTETLTVLEVRYERIAVEQFQPPPESIASTGQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP1</accession>
    <name>E8WZP1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581329.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2992"/>
    <dbReference type="EnsemblBacteria" id="ADW70015">
        <property type="protein sequence ID" value="ADW70015"/>
        <property type="gene ID" value="AciX9_2992"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2992"/>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050859_0_1_0"/>
    <dbReference type="OMA" id="YFPIQKM"/>
    <dbReference type="OrthoDB" id="752123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="29646" checksum="A27BEACF114EFAF6" modified="2011-04-05" version="1">MTDQNFSTLQQQIEHHFAQGPAAIGNPEALAAFATLREALESGALRSASPDPTSPIGWTVNAWVKRGILLGFRLGHLVSAEDGKFVDKNTYPAQIFTAEQGTRIVPGGSSVRAGAFLSKGVVMMPPAYVNVGAYVDEGTMIDSHALVGSCAQIGKRVHLSAAAQIGGVLEPVNASPVIIEDDALIGGNTGVYEGTIVRTRAVLAAGTVLTRGTPVYDLVTGEIHRATADTPLIIPAGAVVVPGSRAITSGKGKDWNLSVATPIIVKYRDEKTELSLALEDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ6</accession>
    <name>E8WZQ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Repressor protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3009</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581344.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3009"/>
    <dbReference type="EnsemblBacteria" id="ADW70030">
        <property type="protein sequence ID" value="ADW70030"/>
        <property type="gene ID" value="AciX9_3009"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3009"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_1_0_0"/>
    <dbReference type="OMA" id="RLPPVMF"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="146"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="36306" checksum="634F3D5B34BAB818" modified="2011-04-05" version="1">MDDTVSRIFVLLETLQGRDRVTGTELAERLDVDLRTIQRYVVRLKSLHIPIDSSPGVGGAYRLRPGYRLPPLVLTNEEAFALSLGLRALRQIGLSAFAPATEGALAKLGRVLPHTLRESLRTVEDVIAGDPSPWSAPASFESLITAATAIRTGHRIHFAYESHNATTSTRQVEPYAVIHMDGRWYLIGHCLSRAGLRTFRLDRVSNLETGTPTFERPLNFDARRYLADHMPFIPAEYEIDVWLDMPLEEAQRNFALWRIALEADAGGTRLRCTRDRLEIFAAMILSTGRPIKIHRPAELRETFRQLATQALQAANDSFEAPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT9</accession>
    <name>E8WZT9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579078.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0680"/>
    <dbReference type="EnsemblBacteria" id="ADW67750">
        <property type="protein sequence ID" value="ADW67750"/>
        <property type="gene ID" value="AciX9_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0680"/>
    <dbReference type="eggNOG" id="ENOG5032YQJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162083_4_1_0"/>
    <dbReference type="OMA" id="MPVILRF"/>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="9685" checksum="818C21707DAA436B" modified="2011-04-05" version="1">MPTVLRVGPYRFYFYSEEGKEPPHVHVEAGEKKAKYWITPVELQKNEGFRSGERREIEQILHQNLTSILSKWNEYFKINTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X068</accession>
    <name>E8X068_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3029</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581363.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70049">
        <property type="protein sequence ID" value="ADW70049"/>
        <property type="gene ID" value="AciX9_3029"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3029"/>
    <dbReference type="eggNOG" id="ENOG5032WZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155939_0_0_0"/>
    <dbReference type="OMA" id="YTHKWEV"/>
    <dbReference type="OrthoDB" id="1719711at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="25768" checksum="3E3BD69FBACE0E18" modified="2011-04-05" version="1">MILISGKKYGGLSSFELGFSGKSLKVAAGLALVGTALAAGAQSSKPRRRESNQNRKNRIQRAVQETYTHKWEVGAGPGYLRFRSGEFKQQNNDVTFWTSAMYSFTPRFGAEALVGGAFGSAKLGNGNPNAVNPQIQSYDFMAGPSYRLVAKEKFGVSVYGAGGAAYGRFSTGPKDFPTAVVGLWPSGTAAAFSVGVNLDYHLYPNLSARITPTYLGTTYGSTIQNTKGVNVGLVYRFGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A0</accession>
    <name>E8X0A0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <ecNumber evidence="3">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3061</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581395.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3061"/>
    <dbReference type="EnsemblBacteria" id="ADW70081">
        <property type="protein sequence ID" value="ADW70081"/>
        <property type="gene ID" value="AciX9_3061"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3061"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_3_0"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="7">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13684" checksum="24D35098E938EA17" modified="2011-04-05" version="1">MNAVNTADNVAIDFGKTDGLVAGMVQDAKTGEILMLGFLNEESYKKTLETGYVTFWSRSRQKLWMKGETSGNRLKVVTAATDCDNDALLFRVEVEGDGLVCHEGTVSCFTKPIAIAVSGDNENDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F5</accession>
    <name>E8X0F5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ada DNA repair protein and transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0749</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579145.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0749"/>
    <dbReference type="EnsemblBacteria" id="ADW67819">
        <property type="protein sequence ID" value="ADW67819"/>
        <property type="gene ID" value="AciX9_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0749"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_0_0"/>
    <dbReference type="OMA" id="ALTGYHW"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016221">
        <property type="entry name" value="Bifunct_regulatory_prot_Ada"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000409">
        <property type="entry name" value="Ada"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from methylphosphotriester" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="40049" checksum="4DEC53CE940CD3E2" modified="2011-04-05" version="1">MTVSSLPPAVSNPKTKVPSLFAGKAWQQVLARDERADGQFVYAVKTTKVYCRPGCPSRRPERKNVSFFPTPALAQAAGYRACLRCEPDSVARKDDPQVKAIDAVTQYLTEHADQRTKLKDVAKATGVAPLTILRGFKRVLGVSPREYAKAQRVAKFKEKVRQPKGTVTDAIYDAGFGSSSRLYEGADASLGMTPSAMKAGGQGETIRFTTAETPLGMIMVAATARGICSIVFGDSAEQLETELALKFPKAERKHMERELSYAVDALIAAMSESPRALALPLDVRATAFQHRVWRELQAIPRGQTRTYSEIAEAIGSPASVRAVAGACAANPVALAVPCHRVIGKDGKLTGYRWGMDRKRTLLTHEGAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G2</accession>
    <name>E8X0G2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579152.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67826">
        <property type="protein sequence ID" value="ADW67826"/>
        <property type="gene ID" value="AciX9_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0757"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493289_0_0_0"/>
    <dbReference type="OMA" id="YTDEGWY"/>
    <dbReference type="OrthoDB" id="1217697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="552" mass="61848" checksum="1077E4417714EC03" modified="2011-04-05" version="1">MTLLPKPFRLLVQTLMLLGAAVFFALHFTHLAADFPNFSPWMDWSKYTDEGWYGDAAIRHYQLGHWYVPGDFNPAAALPVWPLLEAILFRFTGVSLVAVRALTVSVFGGILIASFLLLRRWASLRGSTLAPYAAILLLAVSPFCFVFTRMGILEPLLVLLTLLALLAASHVTHLRPPTGHWKQDLIQSIRPNLLPLLALAVLLPAIILTKTTGLFLVPAIAFLVFAALDYHVLPFLRVSIPTVALAILIWLAYFVGVVRPHYLLDYRYLFSANAYTQITLATATTVLSDTFKDGNWMGKILFPTAVACIAVSAIFFTRLRRHPLIPALLLWALGYAAFLAYHDNLQPRYYLVVAVPLTLLIPVVIEELILTRIRANTPRYLTLAAAAALILTITIPQAHETLHYVRHPEYTLLDAFHQVHDIIVADHNQNPDHNPLVLSISGSDLSLATGLPSICDDFGTLELEDRVKKYRPGWYLTWNKIEDDKMDALDPTFQPERVATIPAMDDPDRNLLILYRLNPTDVTPPTPGKHKPTPRNLRTKVGQQPSTRQLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W9</accession>
    <name>E8X0W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3141</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581466.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3141"/>
    <dbReference type="EnsemblBacteria" id="ADW70153">
        <property type="protein sequence ID" value="ADW70153"/>
        <property type="gene ID" value="AciX9_3141"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3141"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1523075_0_0_0"/>
    <dbReference type="OrthoDB" id="2053588at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="19329" checksum="FEE064A42EA2981B" modified="2011-04-05" version="1">MQTVLNSLPAQEGVRLIEPGEGKPFDLGPVHFQWKVRGEDSAHAYTIFELHLAPGGGVDLHSHASPESFYVLEGEMTFFRIVDGTQEAFVCGPGSTIVIPPNALHALFNKSAGACRLLDVSTVSHQDFFDEVQAADRNESFASLEPKVAGVRLSEIARRNEMYLAPYDVNTKKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y8</accession>
    <name>E8X0Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3161</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581485.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3161"/>
    <dbReference type="EnsemblBacteria" id="ADW70172">
        <property type="protein sequence ID" value="ADW70172"/>
        <property type="gene ID" value="AciX9_3161"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3161"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_0"/>
    <dbReference type="OMA" id="SMDKADF"/>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="47900" checksum="BAD335B3936D674C" modified="2011-04-05" version="1">MFKSEIQSRRSTNSPRQILFASLIGSTIEFFDFYIYGTASVLVFPKLFFPANDPASSMLASLATFAIAFLARPLGAAIFGHFGDRFGRKTTLVVALSTMGISTVAIGALPTYRSIGFLASLLLALCRFGQGLGLGGEWGGAVLLAIENAPAKKRAWYGMFPQLGAPMGFLLSGGVFLLLSRWLTNDQFFGFGWRLPFLASAVLVLLGLYVRLTIAETLVFQEALVQKEPVRLPISSLFRRHGKALLAGITVCLATFVLFYLMTIFTLSWGTTALGYSRSKFLLMQLFDVLFFAAGIPISALLAEHGRRRVMMWVTLLIGGFGFVMAPLFTAGTSGTVVMMGIGLFLMGLTWGPLGTVISEIFPTSLRYTGSSLAFSIAGILGASLAPYSATWLAKSYGLGYVGYYLSVSAALTFLGLLGIRETKDDDLATSSQSFQSGQSRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X119</accession>
    <name>E8X119_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0817</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579210.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0817"/>
    <dbReference type="EnsemblBacteria" id="ADW67885">
        <property type="protein sequence ID" value="ADW67885"/>
        <property type="gene ID" value="AciX9_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0817"/>
    <dbReference type="eggNOG" id="COG5266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_2_0_0"/>
    <dbReference type="OMA" id="NVFNTVQ"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234056" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1170" mass="121282" checksum="846486C539836A77" modified="2011-04-05" version="1">MGMKRGLMVALLAGVRVAGGQDAPAVTSAVQAPAAATAGGTIKGFVKAGTVPLPGVAVTATNTLTGKKYATTTDVNGAYAMTIPRTGRYVVKVELAAFASLTKEVRITAEATDQVAEFGMELASRAAAQEAAATTATTRALASAIGRGTQSLSVLGGGDLGEQTDATAGGGVVGASLPSLSGLGDAGGGDSVAVSGQVGQTNGLAGINEDDLRQRIEDMQARARAQGGGASDQLDAVVGMLGGLMGGAGPGGGGGRGGRGGGGGGRGGGGGGFRGFNPTTPHGAIFYQGGFPALQAQQSSVPSLLALENGGLPQQPQPFLSSQQNRFGVSLTGSPGIPGLVKASSKQFVFLNVTGVRNISPQNYTATVPTLDERGQALVNGALVNTDANLSGAPRALPIYNPVTGTQYVGSIIPNAQITPQARALLNYYPLPNINGATTQNYQEVTTSGTNSTNGSLRFVRNFGAGGFGPFGGGGGGGRRSQANAPKTLRQNFNANFSFSRAATDARNFVPILGGKTQTNGYGLSAGYTVGYGRVTNNATLNWNRSNTETRNYFTGQSLNPTAAAGIAVPSQSAQLAQQGFYNGVPRIGLTTFSSISETVPVSRINQTISFSDFVSYGHKKHNYRFGVDLRRVHADQLGGNNPLGAFTFSGFVTESASDKGNTSTSQPGSGSALADLLLGQPQQTTIQAGLFKTYLRANIGDAYAQDDFRLARGLTLNYGLRFEYFSPYVEKYNRLSNLDHNADFTSVDAVQPGGTGTFGGKYPRSLVNPDRNMFSPRFGVAWRPSFLKETVIRAGYGINFNTGQFATFAQSLAFQPPFAVTQNNVLATTANASGCTIANMTLANGFGCSSKAITNTYAVNKDYRLGHVQVYNVDIQKSLPHGVVVNVGYNGSKGGDLDVVTAPNANATTVTTGNAQAFTFEDSAASSRLQQLVVSARKRLEKGISLQLLYQYGHAIDNASSIGGVGVNGASTVQNSRRLDLEESNSSFDVRHKLTGNYVIELPFGPNRAFLSKGGVASKIMDGFSVSGDFTFATGSYFTPQFTNSAAELAAGGTATFRPDRVFSQPINAGAKNINQWFNPAAFVAPASGYGTASRNSIEGPGTIAADLTLSRTVQLGGTRSIEGRFTGMNAFNTVRYSGIDTSVTSASFGQVTSTASARTVTFLARYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X152</accession>
    <name>E8X152_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0850</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579243.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0850"/>
    <dbReference type="EnsemblBacteria" id="ADW67918">
        <property type="protein sequence ID" value="ADW67918"/>
        <property type="gene ID" value="AciX9_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0850"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_2_0_0"/>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="696" mass="77856" checksum="A4F68DE466C07CF8" modified="2011-04-05" version="1">MSTAPPIPSPTSARPKKLPTLHDFFAPGGILAKSSLAYEHRKGQYDMAKAVESALEDKRHLIVEAGTGTGKTLAYLLPALRHAREHNQRVIISTGTKNLQEQLYFKDIPFLESMLADDYGPLKVCYMKGRANYLCKHKLYALRDSPLLSGLEEIEQFHHITTWERTTPTGDRAELDHLPETSALWSKLDARTEACLGTTCPDWEQCFITQMRRKALESDLIIVNHHLFFADLNIKQQAAGAPDAGILPDASAVIFDEAHELEDIASNYFGIGLSNARIDELTRDVEIMLRAKQASSSAIESACAILKDRSKMFFASLPTTEYQPIGRMPFEHRADYLETEGDAYIGATNALKRLTSELEQVKNVEETKGLIKRTEDIRQHLKFLLESDDPNTVFWIERRAGGSGVRNLARGPAQQIYNTQLQATPIDVSTLLTTSLFDCYPTVVLTSATLTVAAPEGTSPFTHITGRLGLTLNRELVVPSHFNYPKQALLYLPPSMPDPREPDFTMHAVERIRRVLEITKGRAFVLFTSYSQMRLMHDRLLAELPYPLLLHGTAPRHVLLQQFRDTPNAVLFGTSSFWQGVDVQGEQLSCVIIDRLPFGVPTDPILKARMDLIASTGGKPFFDLQIPAAVITLKQGFGRLIRSLNDRGVLMLLDPRIQRQRYGKVFLDSLPPYTVTQSIEDVEAFFAAKAGNSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E9</accession>
    <name>E8X1E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581496.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3173"/>
    <dbReference type="EnsemblBacteria" id="ADW70184">
        <property type="protein sequence ID" value="ADW70184"/>
        <property type="gene ID" value="AciX9_3173"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3173"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_0"/>
    <dbReference type="OMA" id="RWFIANP"/>
    <dbReference type="OrthoDB" id="1064766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="38719" checksum="B04CFE4F2634545D" modified="2011-04-05" version="1">MATLFEPVHLGSLLLANRVFMAPLTRTRADDNGVPSEFAATYYSQRASAGLIVTEATQISPMGKGYSNTPGIHSTDQVRAWSRIVDSVHHSGGRIFLQLWHVGRISHSSLLPNNAQPVAPSAIRANAHTHIATGSAQVSEPVALTASGIEEILSDYRRAASNAKQAGFDGVEIHAANGYLIDQFLRTGTNRRTDDYGGPASNRARFLTQAVERVLEVWDSKRVGVRISPTVDFNDMRDDNPLDTFSVAAGMLNDFGLGYLHVVEQAQDSTGSGEEAVVLSTHLRALWKGLYVVNGGYDGPRGAEALRTGRADAIAYGRAFLANPDLPRRLQLQAALNEPDPTTFYGGGAAGYTSYPWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I1</accession>
    <name>E8X1I1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3205</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3205"/>
    <dbReference type="EnsemblBacteria" id="ADW70216">
        <property type="protein sequence ID" value="ADW70216"/>
        <property type="gene ID" value="AciX9_3205"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3205"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501467_0_0_0"/>
    <dbReference type="OMA" id="CQFQMAP"/>
    <dbReference type="OrthoDB" id="1355870at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="20840" checksum="D5487AB2C54F1061" modified="2011-04-05" version="1">MTTPWSRNKSGEIDRQTQDDNELRMIPWWSVLLAIVAFAAMQFLFHGVLPHHKHEMLPMRLLMGYTYGTLVASYVLLVGYVSRDVKRRNMPAALWMLIVIMMPGGIGAVVYFLLRQPMLSRCPHCSTEIASTTHFCPQCQFQMAPVCGQCFRGVEITDVYCKQCGHDLEEDNVPARLRAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K9</accession>
    <name>E8X1K9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3233</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581556.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70244">
        <property type="protein sequence ID" value="ADW70244"/>
        <property type="gene ID" value="AciX9_3233"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3233"/>
    <dbReference type="eggNOG" id="ENOG5033Z84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113748_0_0_0"/>
    <dbReference type="OMA" id="PRYEWRI"/>
    <dbReference type="OrthoDB" id="1726286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233586" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19877" checksum="D6144365BAD47F79" modified="2011-04-05" version="1">MFKLGSLLSAAVACAALFPCASAYGQAVPTATRAITFQVGGGLSLANNDYSYDYIKGATLFGTIDFKNHFGIEGDIHDTSIFTPQDLGETSYLLGVRYKFNVNGFHPYAKVQAGLGTFNFQSTTYVPSSHTYKIYDFGGGVEHALPHRLNFRIVDLEYQRWPGFGANGLTPIMVTTGLAYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L4</accession>
    <name>E8X1L4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3238</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="4">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581561.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3238"/>
    <dbReference type="EnsemblBacteria" id="ADW70249">
        <property type="protein sequence ID" value="ADW70249"/>
        <property type="gene ID" value="AciX9_3238"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3238"/>
    <dbReference type="eggNOG" id="COG2032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_8_1_0"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015673at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0186">Copper</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234274" description="Superoxide dismutase [Cu-Zn]" evidence="5">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="6">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="18696" checksum="6341D2C9DFE09B19" modified="2011-04-05" version="1">MRVATVALLMCALTVPAMAKKHDKGSVVVPIKTSTGDDAGTASFNENKKGTLTVKLALKNLPPGDHAVHIHQKPLCDAPDFKSAGGHFNPEMKQHGTLNPMGHHAGDLPQNVTVGPDGTANVSFKVPYLSIVLDAPNNILANGGTSIMIHEKADDMKTDPTGNAGGRIACGVIIEPAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M6</accession>
    <name>E8X1M6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0877</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579270.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0877"/>
    <dbReference type="EnsemblBacteria" id="ADW67945">
        <property type="protein sequence ID" value="ADW67945"/>
        <property type="gene ID" value="AciX9_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0877"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_0"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="226"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="453" mass="47892" checksum="E31855638020BB36" modified="2011-04-05" version="1">MLKSSLLACLCATLPFVQQTDVQQTDAQQTAAQTAPAPSLLNTYKQIHAHPELSHYESNTSALLATDLRRSGYTVTDHIGIYPDGTHAFGVIGILKNGPGPTLLIRGDMDALPIVEETGLPYASHVTTKNKAGQEVGVMEACGHDIHTTVLMGTARALAADKSHWHGTLMILGQPSEETIDGAKAMLADHLYDRFGVPDMIIGLHDTNVHAAGTVGISIGNAMASSTSIDVTIRGIGGHGAYPNLGRDPILLSALFITQLQTIVSREEDPRSPSVVTVGSIHGGTKRNIIPDEVKLELTTRAFTEKSRQVILDAIHNMAAGLATSYNLPPAKSPTVTVIDTESAPATYNDPALSARVKAALVTAIGAPNVTEDLPVMGSEDVGVFALPQFNGGHKIPLVYYWLGAMNKEKFAAAQAAGTELPGYHTSHFEPDPIPTLETGVKTMTAAALALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q8</accession>
    <name>E8X1Q8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0910</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0910"/>
    <dbReference type="EnsemblBacteria" id="ADW67977">
        <property type="protein sequence ID" value="ADW67977"/>
        <property type="gene ID" value="AciX9_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0910"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_3_0_0"/>
    <dbReference type="OMA" id="NVGLFVW"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="86"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="280" mass="29988" checksum="E05ECF5E1757B32C" modified="2011-04-05" version="1">MPHDPESEILAPRTATDVAEAYAPGEPADTPVRSEWDPRSAPGTYSLLAVNVAVYLWMLLSGVSWLSPTSEQLMHFGANQSVYVLNGEWYRLLTATFVHIGIIHIGTNMWCLWNLGLLGEPLLGPLGLIAVYVLTGVAGNLLSVFWDVWTAQRYDMPLQAVAGVGAGASGAVFGIAGILIILLSNKRLPIPWSELKRLRTSVVRFAVINIVIGGATMFGGSIRIDNSAHIGGFAAGLALGPGLLAKMTAGRKRYLGRQRLVFFGAAFLLAAIGYGIANMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R6</accession>
    <name>E8X1R6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0918</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0918"/>
    <dbReference type="EnsemblBacteria" id="ADW67985">
        <property type="protein sequence ID" value="ADW67985"/>
        <property type="gene ID" value="AciX9_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0918"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_3_0_0"/>
    <dbReference type="OMA" id="DLTEVWK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="23105" checksum="E79C6D90B58ED6C2" modified="2011-04-05" version="1">MAALAESPVLIQASLAGLPMPVVLRLPEPMTDEELIAFSRRNRPYRIERNADGELEIMSPVGFDGGQRELLVMRVLGNWAEEHGGVCVSCDTGFTMADSSVRSPDSSWISDARINALTDAERRRFPPLCPEFLVEILSETDSRATLQAKMEMWIANGAQLAWMIDPFSATVSVYRPHSAVEVLDRPDWVEADAVVAGFRLETSRLWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S9</accession>
    <name>E8X1S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0931</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579322.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0931"/>
    <dbReference type="EnsemblBacteria" id="ADW67998">
        <property type="protein sequence ID" value="ADW67998"/>
        <property type="gene ID" value="AciX9_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0931"/>
    <dbReference type="HOGENOM" id="CLU_2450463_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9792" checksum="F4B83BAC7D9331FB" modified="2011-04-05" version="1">MQVSLQYATQHLEELASAVDNGEEIEIARPEKSAIKLVVSAKAAQSETEGPRVLGALRGRMIVPSEEEWKKMDEELADIMTNGPVFPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U4</accession>
    <name>E8X1U4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2060</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580422.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2060"/>
    <dbReference type="EnsemblBacteria" id="ADW69105">
        <property type="protein sequence ID" value="ADW69105"/>
        <property type="gene ID" value="AciX9_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2060"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036577_3_1_0"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="410" mass="45737" checksum="39E159E4EBAC4D3D" modified="2011-04-05" version="1">MATSPNSIFLSSGEASGDHYGAQIIHALRASLPNATFTGLGGAEMAQAGQTRIVKAEDVAHMGITEVILHAPYIYSQYRKLVASIRSHPPAAAILIDFPDVNFRLAKHLKSLGIPVIWFVSPQLWAWKRRRLRWVQQRVTRMLTIFPFEEQFYKNRKVQAEFVGHPLAELPLPTITREAYAAHNNLDPNKPWIALLPGSRWREIESNLPTMVEMACRHPRDVEYILPVASTIDRPRLADFTAGWISHYPGSDPTLTLPYIHLVSDAREALHHARASVVASGTATVQAALIGNPFLVVYKVSPITFKLAKSLVWYPPEVWPTEEGTDRNGNLPIAMPNLIAGRRIVPELLQERFNPDALSEALTPLLRDTPTRQRQLEDLAALRQCLTTQGPTPIVRVRDAVLSVLPPSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U8</accession>
    <name>E8X1U8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2064</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2064"/>
    <dbReference type="EnsemblBacteria" id="ADW69109">
        <property type="protein sequence ID" value="ADW69109"/>
        <property type="gene ID" value="AciX9_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2064"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_0"/>
    <dbReference type="OMA" id="THLYYDV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="734" mass="77543" checksum="1E9E0E67BE9FF4FE" modified="2011-04-05" version="1">MQTLTLPITGMSCAACSAYIEQTLNALPGVESASVNLLANQATITSTLPPEALITAIQDAGYDATLPSPELEGVPHVSPLRHGFPQLSTRAFTALTIAAASMLLSMTTLPATPLRYTLLALTLVVMLALSPETYRRAFTAARHRTTNMSTLVAIGTLAALAWSLTATIAPQIFITHGLAPDVYYEAIDFILAFLLLGAWLDSRAKLRTQSALAAFAQLTPSTARVLRNNTEIELPLAALHPGDQILLLPGERIPVDGTVLLGTSTVDESLLTGESIPVLKSPQSPVIGGTINLDGPLTIEATTLGADSVLSQLRRLLSEAQSSRAPMQKLADRASAIFVPTVLALAALTFAAWLLLDHSLPRAFAAAIAVLVIACPCAMGLAVPAALTVGIGRAAQLGILVKNGEALERLAQTRNLALDKTGTLTEGRPKIVAAHFAPNLSPEDHQHLLQLAAALERHSEHPLAKAVQSYIPTHTPFTLTNIKTIPGQGITATYNNQQITIGNEALSHQNRVPQVRTLGPGFPQPSTPTTKLHLTINNQLQLTLEATDTLRESAPQALTQLSTLGITPHILTGDNAATAAAIANLLNIPAAQIHAHLLPADKLTIIQQLQQQAPTAMAGDGINDAAALAQADTGIAISGQNVGTDLTREAADLVLLRPDLTLIPTSIRLARRTTRTMRQNLGWAVAYNLLGLPIAAGALYPHFHILLSPALASAAMALSSISVLFNSLRLRRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X209</accession>
    <name>E8X209_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2126</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580486.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2126"/>
    <dbReference type="EnsemblBacteria" id="ADW69170">
        <property type="protein sequence ID" value="ADW69170"/>
        <property type="gene ID" value="AciX9_2126"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2126"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_1_0_0"/>
    <dbReference type="OMA" id="IGGWKCA"/>
    <dbReference type="OrthoDB" id="1314120at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="27806" checksum="CC97A2FF208DBB3F" modified="2011-04-05" version="1">MTTTKLSGLSGPREAQLLEAVDLLLDARRTGNPIQDLPPALAPTTEAEAFWIQGQLAESFGSIGGWKIGAPSADATPSFAPMPLAWMAPGGSKIKGHTSRYRGLEAEVAFLLGDNLPPRATPYSRNEVIAAIASCHPAIEVLESGILDPGIVPTLNKIADLQINGGFIYGPPCPEWRTVDFTQEQVVLAVDGSVRVERTGSNTAGDLLRLLPYLANEGAARTGGLRAGQWITTGSWTGNTLATASSSVDVHFSTIGRVTTRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X224</accession>
    <name>E8X224_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3256</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3256"/>
    <dbReference type="EnsemblBacteria" id="ADW70267">
        <property type="protein sequence ID" value="ADW70267"/>
        <property type="gene ID" value="AciX9_3256"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3256"/>
    <dbReference type="eggNOG" id="ENOG5033715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123308_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="25102" checksum="3484846F3F4EBFF1" modified="2011-04-05" version="1">MLNLSLKRWTLRLVLMGFLALAGGVGFGQAASGQAGGLDVPAGTVEGVLLGMANQAGVIFAGQVVSVTRADGNGYVDVAFRVDQAVRGCDTGGTYTVREWAGLWVGQTERYRVGQRLLMLLTAKGAGGMSAPVNGMDGAIPVVANVAPPLMRNGVVPADTGVDEAGGLVDLRWIRARVTRGIGSGTSAASGNAVQAQVTASWVPVTGTPFQPISDWVGPIAPMPPGGPGSTTEPSLSSVLVLLAGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X236</accession>
    <name>E8X236_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3268</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581591.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3268"/>
    <dbReference type="EnsemblBacteria" id="ADW70279">
        <property type="protein sequence ID" value="ADW70279"/>
        <property type="gene ID" value="AciX9_3268"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3268"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_0"/>
    <dbReference type="OMA" id="TPPFWAS"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="14"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="541" mass="59260" checksum="6A7DBC889B6163DA" modified="2011-04-05" version="1">MSPADNLHAFQLVFLLLLIFVAAFTLLARRLNIAYPIVLVVAGLLISFVPHIPVVPLNANLIFLIFLPPLLFSSAYATSWRELRANGLSIGFLAFGLVAFTVFAVAEFSDRFITALDFKSGFILGAVVAATDAIAATSIASSLGLPRRVVDILEGESLLNDATALLALEFGLQMLLDGTTPTVSHALVRLLWLTVAGSAIGFVIGFLVAKLNDVIDDGPIQIVISLITPYAAYLAGESVHASGVFAVVAAGLYISRQHATIFSPQVRIQLHSVWDALTFLLNGVVFALIGLQLPVIMGFMHPNYTWPQLLGYGAIFSLILIALRLIWVFPVAWIAHQIDLRISRHPNPTPNPKSVFIIGWTGMRGVISLAAAISLPQTLGDGRPFTTRSLILFLTFSVILVTLVLQGLTLPPLIRALKLSTPHRTDEEEYEARRTSLNAAIAYLEQDQASQGDRFAHIYEDLIHRYRHRLAAVGGPTEDDPNHRLDGATYERLRHIAAGAIHAERNTMITLRNQGHLSDEALRKMEHELDLQQSRYEAAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A5</accession>
    <name>E8X2A5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M1 membrane alanine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0970</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579361.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0970"/>
    <dbReference type="EnsemblBacteria" id="ADW68037">
        <property type="protein sequence ID" value="ADW68037"/>
        <property type="gene ID" value="AciX9_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0970"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_1_0_0"/>
    <dbReference type="OMA" id="GGMEYAM"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230180" evidence="1">
        <location>
            <begin position="23"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="316"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="707" mass="78447" checksum="E7D8E7A9C334838B" modified="2011-04-05" version="1">MRPLFTAATLLFVAFAAKPGHAQSIATNSPTPLSTRVVAYNLDAKVDMDKKALDATETLTYKNLTGQPLTTFPFHLYLNAFRPESSFTSETHFGGGIRDSESANDYPAKKLGGITIASIAADGMGDLTKSMHFTAPDDNNQNDHTVAEIALPRPLAPGDSITFHIAFHDQFPESIARNGYKRDFLMGGQWYPKLGVFWHGAWNCHQYHSTTEFFSDFATFNVRLTLPRRFTVGASGVPTGDQANSDGTKTLSFYGEDIGDFAFAASPHFTVTDGTFLSSLGPVQVHVLALAAHPDAGQRYLKILLASLDQFDKRYGPYPYKVLTLIDPEPDSQIGGMEYPTLVTGDTNVWDPSHVTELTAEHEFGHQYWYGMVATNEFEDAWLDEGINSYTEVNVLAAILGPRTSFFQHRWANAGDAELQYLQYISEPDYDPVTRHAWQFRNAASYGGVTYGKTATLLKTLEGIVGRDTMDEAMRTYFMRYRFTHPTSEDFLHTIEDVAIKRGKATALASIPGTSPTATQPSTQLYGLTAQPNSLIGAGVNLGQYQAVMNTPGQPNINVGSTLRPFFNQAVYGTRILDFAVDKVTSDPAQWWKAEHGQTQFLDTVTLHRLGDFQLPVTVEIVFEDGTKLRETWDCTHDINDRWHTFTYTRGSKVLSAELDPDHTVSLDRDHFNDSYTTKANHVPAHKLTNIYASALQFASQLAGWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I1</accession>
    <name>E8X2I1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2161</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580521.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2161"/>
    <dbReference type="EnsemblBacteria" id="ADW69205">
        <property type="protein sequence ID" value="ADW69205"/>
        <property type="gene ID" value="AciX9_2161"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2161"/>
    <dbReference type="eggNOG" id="ENOG5033QU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_938839_0_0_0"/>
    <dbReference type="OMA" id="SIWYPIN"/>
    <dbReference type="OrthoDB" id="1339078at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="31285" checksum="037B6E25A47988AA" modified="2011-04-05" version="1">MATENEIERPGADTRIEMPSPTAWPLVLALGLALSISGMVTSAWVTLVGVLMFVYAASGWFREILPHEAHEWMEVTGERVEITRSKREVARLSGSSTHQQVQPVETFSLLAGIEGGVAGGIAMLVPAVIYGLLKEHSVWYPVNLLAAGGFPSWSNESNAFLAQFHWKGLIAASIIHGVTCPLVGLLYAAVLPMFPKRPILMAGFVVPLFWTSLIYSMLGLISPILNQRIDWDYFIPSQLAFGLVTGWVINRHIHLRGTDFSSLPFAVRAGLHSDVRNRDDADGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K9</accession>
    <name>E8X2K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2189</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580549.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2189"/>
    <dbReference type="EnsemblBacteria" id="ADW69233">
        <property type="protein sequence ID" value="ADW69233"/>
        <property type="gene ID" value="AciX9_2189"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2189"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_0"/>
    <dbReference type="OMA" id="TANYICA"/>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="437" mass="46579" checksum="7F9127F11B055735" modified="2011-04-05" version="1">MSKPLSPGATGAKAINTPAQVLFASLIGTAVEFFDFYIYATAAVIVFPSLFFPKSDPAAATLLSLATFGVAFLARPIGSALFGHFGDRIGRKTTLVLALGTMGLSTFLIGCLPTYSLIGVAAPLLLALCRFGQGIGLGGEWGGAVLLAVENAPPNKRAWYGMFPQLGAPLGFFLSGLVFYLLSHLLTNRQFLSFGWRLPFLASAALVLLGLYVRLTITETPVFEAARKRGEQTEMPVLKVFTHYTKSLVAGIMICLATFVLFYLMIVFALSWGVNALHFTRDKFLLIQLFGVIFFAGTIPIAALLAEKGRRVVMIAVSVAIGIFGLVFAQIFQAGTTGAIVAMCLGLALMGLTYGPLGTIISEIFPTSIRYSGSSLAFSFGGILGASATPSIATWLATHYGLQYVGYYLTGSAVLTTIGLLWIHETRDEDLTTAPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L3</accession>
    <name>E8X2L3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="10" type="ordered locus">AciX9_2193</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580553.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2193"/>
    <dbReference type="EnsemblBacteria" id="ADW69237">
        <property type="protein sequence ID" value="ADW69237"/>
        <property type="gene ID" value="AciX9_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2193"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_0_0_0"/>
    <dbReference type="OMA" id="NFKIFLD"/>
    <dbReference type="OrthoDB" id="1150446at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="24094" checksum="D1E4DBEB602996A9" modified="2011-04-05" version="1">MPHSLTPRDQLIVALDYPTAAAALALVDALDGQCLWFKVGLELYLAAGAPIVTTLRQRGFNVFLDLKLHDIPNTVASAVRSVSSLGASLLTLHAAGGPAMLAAAAEAASATPDAPTLLAVTVLTSMDNTQLNSIGVPGTPADQVLRLAHMAAAAGVPNLVCSSEELTALRRDLGPSPRLVVPGIRPTGASTDDQQRIATPAAAIAAGASMLVVGRPITKAANPAKAAEAILHEISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P0</accession>
    <name>E8X2P0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581649.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3328"/>
    <dbReference type="EnsemblBacteria" id="ADW70337">
        <property type="protein sequence ID" value="ADW70337"/>
        <property type="gene ID" value="AciX9_3328"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3328"/>
    <dbReference type="HOGENOM" id="CLU_2806444_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7652" checksum="3482132DFC7D5E33" modified="2011-04-05" version="1">MRRLERHHSVKQAAELTGLTARTLYNKRWKGELKGEKIGRKLVFAESELRKLFASHHPTKSPADVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P5</accession>
    <name>E8X2P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3334</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70342">
        <property type="protein sequence ID" value="ADW70342"/>
        <property type="gene ID" value="AciX9_3334"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3334"/>
    <dbReference type="HOGENOM" id="CLU_2355773_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="10557" checksum="CEC5EE514C339C8C" modified="2011-04-05" version="1">MIHNRGGATLASFNIDTEFAIPAVNDSLEYVDEDGEDQIAVVIARNFRYTSPPAPGKKVLSLVLTVKGDKTDPFEINIPAAYEERFAKAFQTKVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V6</accession>
    <name>E8X2V6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1027</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579413.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1027"/>
    <dbReference type="EnsemblBacteria" id="ADW68090">
        <property type="protein sequence ID" value="ADW68090"/>
        <property type="gene ID" value="AciX9_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1027"/>
    <dbReference type="HOGENOM" id="CLU_2142375_0_0_0"/>
    <dbReference type="OMA" id="TTNTHNP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="11977" checksum="DB6D6F6E2CFEC62B" modified="2011-04-05" version="1">MKINSEGRYPEMSDALDARMTRALEQSPTFSIPEGFAARLAAANPPRVAPRAIATNIGRSMLFVAIAVLLLVMVALAPAALRASAPSLALEFSFAVEFVVLVCYVSLKPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z1</accession>
    <name>E8X2Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579448.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1062"/>
    <dbReference type="EnsemblBacteria" id="ADW68125">
        <property type="protein sequence ID" value="ADW68125"/>
        <property type="gene ID" value="AciX9_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1062"/>
    <dbReference type="eggNOG" id="ENOG5032X9U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018474_0_0_0"/>
    <dbReference type="OrthoDB" id="1621671at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="27800" checksum="59D6753ECF90EF4B" modified="2011-04-05" version="1">MRPKSALIWLLAIFQLWLAHAIGYMVHEYAHSFIAWFCHAKANPLALDYGRTNLENFLFLSDIDENVDYAPLFAEGRNHVAALIAVAGVLIGNGLSYLASRLLYERASSQYQRRWAMFYFWIGVMSVGNFLSYVPVRTFASHADMFTVVRGLQVSPWVIALGLGIPFALAIWHFLARILPQAASFLFGTEPVLQGVFILMTTYFVFVFFGGAGIKNYGNAGYWISACCVYLLFPIATILCLQAPKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X321</accession>
    <name>E8X321_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1092</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579478.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1092"/>
    <dbReference type="EnsemblBacteria" id="ADW68155">
        <property type="protein sequence ID" value="ADW68155"/>
        <property type="gene ID" value="AciX9_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1092"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868271_0_0_0"/>
    <dbReference type="OMA" id="CERYGGG"/>
    <dbReference type="OrthoDB" id="613248at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="35721" checksum="FBEF9D2E21B03558" modified="2011-04-05" version="1">MAFRVLHHDRCFDGACSAAVFTKFHRECVGGASGYEYVGLAHRPGGTFDDGVFGPGENAIVDFKYSRSPKVTWWFDHHQSAFMTAEDRADFEAGQAGLSGPKALQEFFDPAYVSCTGLIADIGKAKFGFDTSGLGELLKWADIVDGARYESAKSAVEMDAPAMKLTLCIENAADGFIPRIIPLLTEMSLQEVLDQAFVQEAVGPLWEKHVAAMELLKERMEFRDGVIYYDITDRVTEGISKFIPYYYYPEATYTIGLMKSSFRTKISVGTNPWTTKPSAELVNLAEICERFGGGGHARVGAISFGADEEARGREVALGIVAELRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A3</accession>
    <name>E8X3A3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ordered locus">AciX9_3398</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3398"/>
    <dbReference type="EnsemblBacteria" id="ADW70404">
        <property type="protein sequence ID" value="ADW70404"/>
        <property type="gene ID" value="AciX9_3398"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3398"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193257_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="12349" checksum="EC62CD38B2C8A381" modified="2011-04-05" version="1">MRCGGRTTGFEPWIVYTWRVVQKCVREFSGLRTDRFRTTKGIIMPKLKTHSGAAKRFTKTGTGKFKRGHSKMRHILTSKNNKTKSRLGKSGLVSDADHYNVSRMLPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G2</accession>
    <name>E8X3G2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ordered locus">AciX9_3458</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581774.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3458"/>
    <dbReference type="EnsemblBacteria" id="ADW70463">
        <property type="protein sequence ID" value="ADW70463"/>
        <property type="gene ID" value="AciX9_3458"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3458"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_0"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="35509" checksum="27B985AA91C032E8" modified="2011-04-05" version="1">MPVEIVVDAMGSDKAPESEIRGAILACRTLDVHVALTGPEDILAPALETALGGRRFGARLPIRIVHASEWITMDDKAASAVRSKRDSSMRVGLKLVREGKADGFFTAGNTGAAMATAKMVLGGLSGVDRPALATIMPSMYGQPALLLDVGANVDSDPENLVQFAVMGSMYARNVLKVSNPRVGLLSIGEEDSKGNSLTRDTLPILRTIKGINFIGNVEGRDLFNGTADVIVCDGFVGNVALKTSEGVAKLVSFTLRESLKSTVTSQVGALLSRTAFNAFKKRLDYSEYGGAPMLGVRGVCIVGHGSSNDKAVMNGIRVAAEFAQAEVNSGIEAALVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H9</accession>
    <name>E8X3H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1107</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579493.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1107"/>
    <dbReference type="EnsemblBacteria" id="ADW68170">
        <property type="protein sequence ID" value="ADW68170"/>
        <property type="gene ID" value="AciX9_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1107"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_0"/>
    <dbReference type="OMA" id="AYLPIMS"/>
    <dbReference type="OrthoDB" id="123223at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="302"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="581" mass="61587" checksum="269A414291D1AE46" modified="2011-04-05" version="1">MAFSRVIGTELKVTGKSAKNAAAVKELIAEIRKQEQGIRAGGGEKAVAAQRAKGRLTARERIGLLVDSVETHVPEAGHGALGIAGFLELGLWAAHGMYAEWGGAPGAGVVCGLGRVQGKLCMIVANDATVKAGAFFPMTAKKVLRAQAIALENRIPTLYLVDSAGVFLPLQEEVFPDQDDFGRVFRNNAVMSSLGVPQMTAIMGMCVAGGAYLPVMTDTVLMTEGSGLFLAGPALVQAAIGQKTPAEELGGAAMHAEISGTVDYKEADDPACLERMRSLVGMIGARAEAPFSRAEFDAVADAPKFAAEDLYGLLDPASGASNVYDMHEVIARVLDRSEFDEYKVEFGRTVICGYGRIDGRAVGIVANQKLNQTQTVAMGPMAGTKRIEVGGVIYTEAAQKAARFIMDCNQNLVPLIFLHDVNGFMVGKDAEWSGIIRAGAKMVSAVSTSVVPKITVIVGGSFGAGHYAMCGKAYDPRFIFAWPTARYAVMGGAAAANTLAEIKAKQMERAGETVSDERRQELWAEIKAGYDAAADPRYGAARLWVDAIIDPVETREVLMVALEACALNPEVAKWNVGVMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L9</accession>
    <name>E8X3L9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1147</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579533.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1147"/>
    <dbReference type="EnsemblBacteria" id="ADW68210">
        <property type="protein sequence ID" value="ADW68210"/>
        <property type="gene ID" value="AciX9_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1147"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044569_0_0_0"/>
    <dbReference type="OMA" id="IVNFHCR"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="241"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="316"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="484" mass="53302" checksum="0131EFD32B633336" modified="2011-04-05" version="1">MSPTATIQQQAERHAAKRHAALLSVVSATLVTLLKLLTGILTGSLGMLSEAAHSGIDLIAAGLTLFSVQVADRPADDDHNYGHGKIESLSSFIETVLMFASAMWIIYEAIHRIFFRSHLSLALNIWPFLVLLVSIAVDYTRSRNLRATAALHNSEALAADAVHFGTDMWSSFAVLLGLIATALGERLHAPKLELADPIAALIVSAIILKVTWTLARTTADNLLDATPAHDGQNAAQTRRKLIQDLAAIDGVLAVNRLRTRRAGSGYFADLTLAMPRNLTFQRSEQITMAATDAIQRVLPDADVVVHSVPTATIAESVHDRIRAVAFRANLSIHDVSVQQYDNALHVDLHLEVDETLPLRAAHDIVTRLESNIRAEIPQIASILTHIESEPATIERPAALERDRHLEQLLRKVSQNFPEILDTHDITITKHHDRTQVSCHCTLPDELPMSRVHEIITAFENAFKLEAPEVTRLFIHPEPATDNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M2</accession>
    <name>E8X3M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">H+transporting two-sector ATPase B/B' subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_1150</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579536.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1150"/>
    <dbReference type="EnsemblBacteria" id="ADW68213">
        <property type="protein sequence ID" value="ADW68213"/>
        <property type="gene ID" value="AciX9_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1150"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_9_2_0"/>
    <dbReference type="OMA" id="WNSERDA"/>
    <dbReference type="OrthoDB" id="1887568at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="16690" checksum="07ADC1B3E701436E" modified="2011-04-05" version="1">MNEILNQLGALILGSIPTMVLFIVLVIAYGVLVRRPLENILAKRRALTTGALEQAKGAMSAAEAETVVFEDKLRGAKSEIFQAREAKLKEWNGQREQSLAQARTVTQERVAAAKGEIERSMAEAMQQIETMSGELSASIIKAVLPAGVNGAEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X445</accession>
    <name>E8X445_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="11">3.4.24.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0014</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578434.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67105">
        <property type="protein sequence ID" value="ADW67105"/>
        <property type="gene ID" value="AciX9_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0014"/>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_0"/>
    <dbReference type="OMA" id="APRNHDA"/>
    <dbReference type="OrthoDB" id="305005at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234348" evidence="8">
        <location>
            <begin position="21"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13_N" evidence="10">
        <location>
            <begin position="51"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="9">
        <location>
            <begin position="482"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="684" mass="75248" checksum="E9F2E3F731E8D8BD" modified="2011-04-05" version="1">MKLKMAAAVLSLLGGVGAGAQGTVLPVVQPLSAIPFSPVLDLTSLDKTVDPCVDFYKFSCGGWMKKNPIPADQASWSVYHKLAIDNQQFLWGILKDDAVAKDRTPVQQKVGDYYAACMNTPAIDALGMKPVEAGLARLDMITTREQAAHAIATLHHNVAGSFFFGSGVGQDAVDSSTEIVEVGAGGLGLPDRDYYLKTDAKSVKLREQYVAYVQQLMTLAGEPSEKASADAKAILTIETALATGSLTVVERRDPHKIYHMMTLAELGGLAPGIDWAGYFKTQGAGAFTKLNVSQPEFMKAVQAELMTEPVEALKAYLKFHMLTAAAPYLSHPFVQANFDFYSKTLRGVPTMPARWKTCTGGVDRMLGEALGQEFVRRTFSSEMKAKTRTMTEQIEAAMKGEIEGLDWMSPETKVEAERKLHAIRNKIGYPDTWRDYSTLEVKPDDYAGDAVRAYRFEDARNWNKLGKPVDLTEWGMTPPTVNAYFNPQMNDINFPAGVLQPPLYDAKEDDAPNYGNTGATIGHELTHAFDDEGRQFDDKGNLRDWWTAADAKGFEQRIQCVRDQYAGYVVVDDIHINSKLTSGEDVADLGGTLLAYIAWKKETAGQKLMPINGFTPDQRFFVGMAQWACENERPENLRVSAATDPHSPGFARINGVVSNMPEFKNAFQCKAGQAMVHVPACRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X487</accession>
    <name>E8X487_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hopanoid biosynthesis associated glycosyl transferase protein HpnI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0056</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578476.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0056"/>
    <dbReference type="EnsemblBacteria" id="ADW67147">
        <property type="protein sequence ID" value="ADW67147"/>
        <property type="gene ID" value="AciX9_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0056"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_2_0_0"/>
    <dbReference type="OMA" id="NPKLNNC"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017835">
        <property type="entry name" value="Hopen-assoc_HpnI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="PTHR12726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03472">
        <property type="entry name" value="HpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="42766" checksum="2930D5B72185BD60" modified="2011-04-05" version="1">MEVLPLLIEAATALLTACGLAYMVLALWGARAYVRSVRKHSAPADAAPGVTLLKPLKGVDPRMYAGLASHCRQQYAGPVELVFGVHSLTDPAVAEVERLRTEFPEAAIKLVECTQRLGTSGKVSNLVQMLAAAQYEHVVINDSDILVSPHYLTGVMRYFADPRVGMVTAPYLGRTGLGGRERTVWARLEALGISTDFMPGVLTARKLEGGIRFGLGSTLAMSRTALTKAGGMEALVEYLADDYELGKRIAAAGFTVELCGEVVETTVPGYGLKDFWDHQMRWARSTRDSRKLGYVGLGVTYCVPWAILTVIASGGALWSISLLVFSLLARIAVALTVGVGILRDEQVLRDLWLLPVRDLFGLLFWFWSFAGDTVVWRGEEFRLKDGKITRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K7</accession>
    <name>E8X4K7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580733.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2380"/>
    <dbReference type="EnsemblBacteria" id="ADW69417">
        <property type="protein sequence ID" value="ADW69417"/>
        <property type="gene ID" value="AciX9_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2380"/>
    <dbReference type="eggNOG" id="ENOG5033MEC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170983_0_0_0"/>
    <dbReference type="OrthoDB" id="2051300at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9252" checksum="01C706BD19F9153F" modified="2011-04-05" version="1">MALNQVLEHIDAEIARLQQARALLTDTPAAALKSGRGRPKGSKNAVAAAAPTPAIKGKRKLSPEGRKAIADAMKKRWAERRKQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T5</accession>
    <name>E8X4T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581885.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3570"/>
    <dbReference type="EnsemblBacteria" id="ADW70574">
        <property type="protein sequence ID" value="ADW70574"/>
        <property type="gene ID" value="AciX9_3570"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3570"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_0_0"/>
    <dbReference type="OMA" id="IQTGRME"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="35680" checksum="FB19D1D541A5FDCC" modified="2011-04-05" version="1">MPENSSKPNAPDPLARAPLAYEDLDFLNSPDARMIRILSEYQEPLVRFRRERIEDTVVFFGSARFRARSVADQNLELLENTGSAAAAPEPEQPATPEQIAAGDASALKLSLAHSAVEMSRYYEDARTLACKIATWAKTLPGPRHRFVITSGGGPGIMEAANRGAWDAGAKTIGLNIKLPFEQYPNAYISPELNFEFSYFFMRKFWFAYLAKALVVFPGGFGTIDEMFELLTLVQTHKLAKDLPVVIYGSEYWKSVLNLELLAAKGAIAQKDLDLFQFADTPDEAFAILQPALAAAVADDATDHPPADPAPTAQQTLGPDITKTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V8</accession>
    <name>E8X4V8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70597">
        <property type="protein sequence ID" value="ADW70597"/>
        <property type="gene ID" value="AciX9_3594"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3594"/>
    <dbReference type="HOGENOM" id="CLU_1765456_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16041" checksum="A8368577AB775F7B" modified="2011-04-05" version="1">MAKWISVAGRKGRPPGVEMIFQRLAKELKQNICTVDRFLQVVSIWEDRSMKRWHGVAIFVAGLSVGGAFFAGRQVPVVHAQSTNNYSGCKTLVPKDWGKYEGASLFGITFEDDKGTLRFVGHPNCGGLGETGDSVGLSIADLTIVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y1</accession>
    <name>E8X4Y1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0082</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0082"/>
    <dbReference type="EnsemblBacteria" id="ADW67173">
        <property type="protein sequence ID" value="ADW67173"/>
        <property type="gene ID" value="AciX9_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0082"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="176"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="395" mass="44604" checksum="F8FB5FE6BE0FD275" modified="2011-04-05" version="1">MKGLVKANAHLARSGTDYQTKRIAEVTVQCSCGCGQDFQRPSGAVNAHGPNYISLEHMGRHRTQIYLEDMCGSFLSVIKEYLDGFCRQHYKNQGTIRAAVCPFILFLNERGITDLENVTPKTVTEFISWATEVDYKSSPQHISVLNGFFKWALRHGHRKSGSPVIAKFHGKKRAQHLPRPYTAEEMTIIWALAEERGNSRLRAIIAIGEESGLRLGEICRLREEDVDLVGHRLFVRLPNKTDCERWAPFSDKTARYILEWRSERDDKCGHDFLFHNSLGDPPRADTMHRELCRTFCKIHGGTQVNPSGLDEWSTHRLRHTMASRLASGGASFPTIMAAGGWKSPSSMMHYTKVDADQARHGYDQAMRRAEEKSKTGRSKHILSPGDFLAAYGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X502</accession>
    <name>E8X502_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0116</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578522.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0116"/>
    <dbReference type="EnsemblBacteria" id="ADW67194">
        <property type="protein sequence ID" value="ADW67194"/>
        <property type="gene ID" value="AciX9_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0116"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_0"/>
    <dbReference type="OMA" id="NIDYKAY"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="25407" checksum="699E66F6BEBD10E5" modified="2011-04-05" version="1">MAKIALVTGANKGIGFEVSRALGEAGFTVLLGARDAARGEEAAAKLRAEALDVRFVHADLEHAYETSTALVEKISKEFGHLDVLVNNAGVADMTGADSSASTASIDAIKRIFNTNFFGTVEFTQPLLPLLKASPAARIVNVSSGLGSLEINTNPDSPFYGVKPLGYNASKAALNMFTVNLAWELRDTKAKVNSVCPGYVATDLNNHSGPGTAADGAIAIAKYAQIGEDGPTAGFFHKDGAYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X507</accession>
    <name>E8X507_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0121"/>
    <dbReference type="EnsemblBacteria" id="ADW67199">
        <property type="protein sequence ID" value="ADW67199"/>
        <property type="gene ID" value="AciX9_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0121"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="24242" checksum="0BFAB190DE380FF4" modified="2011-04-05" version="1">MDQAQIFKPCDLSTDRLVIAPNTTRQVHHSNRSKPLNDHQKRKQSFFWRKRMMQARSSSSYGGALITETGNDPKVKALVYVSALQPDAGESPFELLTSKPAASATVKFTADGYAYLDSAHFQEDFAADLSKADTDFMADSQMFVAVKCLQAPVSVAAWREKPSYAIVAIEDRSLSPDLQRFMYQRSKSTVTELVGSHSIYISQPEAVADVIVTAAREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X560</accession>
    <name>E8X560_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579647.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1262"/>
    <dbReference type="EnsemblBacteria" id="ADW68324">
        <property type="protein sequence ID" value="ADW68324"/>
        <property type="gene ID" value="AciX9_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1262"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_0_0_0"/>
    <dbReference type="OMA" id="WVIQRFR"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="30405" checksum="7B5CE26D86A6A436" modified="2011-04-05" version="1">MSSLIVRPMTVRRWRPCAELWPFVEAYGFRAAEFGTSQVYIPLPARRDCFLEFYLQGRYRIVTVTTGTEHWAPRCVLVGPSTQRKEDLKLSGSLQVFSIRFSPVGFRALFGIPASALRDRALEAEHVLGREIVEMHGQLAAVGPAQWESVAEQYLLKRARALGISAESRVAHQAAAAMQRSRGKMAVAKIAAGSAVSTRHLERLFHEQIGVSPKVFGRLLRLDHALELAGSGSNWAEVANSCGYFDQSHLVRDFRAMTGATPLEFAALRAAPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X595</accession>
    <name>E8X595_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ordered locus">AciX9_1297</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579682.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1297"/>
    <dbReference type="EnsemblBacteria" id="ADW68359">
        <property type="protein sequence ID" value="ADW68359"/>
        <property type="gene ID" value="AciX9_1297"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1297"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_0_0"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="271" mass="28260" checksum="9FBBB47E549F66DD" modified="2011-04-05" version="1">MSLANPNGPTIGVFDSGFGGLTVLRALLPLIPGARYLYLGDTARLPYGAKSQQTIARYALSSAAFLLEQGIEMLVVACNTATALALDDLKQALPIPVVGVIAPGTAAAASANADTNVLVLATTATVQSGAYTRACTALGLTAYEKACPLLVPLVEEGWIDHPVTAEVLRIYLTEALEEAPNATTLLLGCTHYPLLRPMIERTLTALNHPLKIIDSATATAHAAAALIPASAQSAHATCTFYATDSIEKFQRLGTSFLGQPLPEVHLIDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K1</accession>
    <name>E8X5K1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3625</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581939.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3625"/>
    <dbReference type="EnsemblBacteria" id="ADW70628">
        <property type="protein sequence ID" value="ADW70628"/>
        <property type="gene ID" value="AciX9_3625"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3625"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_5_1_0"/>
    <dbReference type="OMA" id="KEDMITI"/>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="11188" checksum="B2356686F9144442" modified="2011-04-05" version="1">MLGMWLQSAGFLGNGGITSLALPVLFFVALYFLMIAPNQKKQKAWTQMLADLKSGDTVTSTGGLRGLVLQVKDDCVIVRTQPDGVKLEFVKSSIAAVVTAEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P1</accession>
    <name>E8X5P1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3667</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581977.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3667"/>
    <dbReference type="EnsemblBacteria" id="ADW70668">
        <property type="protein sequence ID" value="ADW70668"/>
        <property type="gene ID" value="AciX9_3667"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3667"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_1_0"/>
    <dbReference type="OMA" id="ETVVMWW"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45544" checksum="5FA6AC58E29DB9B9" modified="2011-04-05" version="1">MSRLELFSILVTTAALFGWASRRWLKLPLTIGTMVLTVAAALGLLGLDQIIPAHLIPGLHPWALHLLGEIDFENLILHGMLGLLLFAGAFLLDLEALAKEKLAVALLSLPGTLLSFLATAALMHWLLPLLGMQAPWLPCLFFGALISPTDPIAVLEMLGRAGVSRNLKAQLAGESLFNDGVGAVLFIALLEVSRGTIASPIHFILLQVFKAAAGLALGVLASWFSSWMMSQVDAYQVEILFTISLAVGTYALAERLHVSAPLTAVAAGIALRHFNLRHHHDDISHTRLDRFWEVIDEVQNAILFVLLGLEILAIPFTRLSLESGLVAIVSVSVVRFAVVAAILMLLRLLQPSHQSSIRTLTWGGLRGGLALALALAVPAHQGRAWILVATYSLILFSIVFQGGSMDVILGRVARKQGREPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U9</accession>
    <name>E8X5U9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4038</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572745.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70833">
        <property type="protein sequence ID" value="ADW70833"/>
        <property type="gene ID" value="AciX9_4038"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4038"/>
    <dbReference type="HOGENOM" id="CLU_020336_9_0_0"/>
    <dbReference type="OMA" id="LVNIGTH"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="38881" checksum="D3D9FA63F7EE82BF" modified="2011-04-05" version="1">MVRTLWLLILAPLLPVVGLLYQWIGLRYDRRRFLRLGRLVDIGKRRRLFMMEMGDEAGPSVIFESGIGSTSQNWARIQESVSEFAHTVSYDRLGLGWSTPAVSERIPSMVVQELRAMLQAAGIAPPYLLVGHSFGGLVVRYFAAEYPDEVIGVVLVDAMRTDEWPPVDESQRKLLDRGVQLTQWAVPIAYSGLARLTTMSFLHRSGRFTNLFTRVTGGRDVLERVTSELNKMPSAVWPIVAAHWSNPAYFRGMTAHIKGVPATVAEMLEATPIVGMPVVLLTPGHPKAISDTDLRKIGLDAEQLIAEKSGHWVHLDEPELVIEQIREMITVVRTGSPCKDTIEESVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X680</accession>
    <name>E8X680_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4185</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70964">
        <property type="protein sequence ID" value="ADW70964"/>
        <property type="gene ID" value="AciX9_4185"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4185"/>
    <dbReference type="HOGENOM" id="CLU_031475_1_2_0"/>
    <dbReference type="OMA" id="GRFVMTN"/>
    <dbReference type="OrthoDB" id="844031at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PTHR38643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233730" evidence="1">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="39087" checksum="71C1203A9FB84973" modified="2011-04-05" version="1">MLRRVAVFAFLLMVGWCAYANAQTKPWPIKVVIVTSFEIGKDTGDIPGEFQLWVEREHLTESLEFAGGVHPILTNADHSVIGIVSGTTLVNATASVMALGLDPRFDLTHAYWLINGIAGVDPEDASIGSAAWVHYTVSDISRFIDPREMPSDWPYGYFTIGAVKPNELPPANGIIHDRQNVYELNGALTQWAYEQTKGVELLDVDAVKTFRGEYKGYPNAQRPPFVLVGDTYASDSYWHGAKMTQYANEWVKLFTKGHGQFVMTDMEDSGYAEALQRLDRMHRVDYQRVMLLRTGSNYSMPRPGHTAVESVTAPYIGTRPAVENAFRVGDVVVREILAHWTLYANKIPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B0</accession>
    <name>E8X6B0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4216</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572906.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70994">
        <property type="protein sequence ID" value="ADW70994"/>
        <property type="gene ID" value="AciX9_4216"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4216"/>
    <dbReference type="HOGENOM" id="CLU_2129933_0_0_0"/>
    <dbReference type="OrthoDB" id="262439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234233" evidence="5">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="12035" checksum="F055101DD9478697" modified="2011-04-05" version="1">MLTPFKSILNVCLALTSVFAARLLVSSATVHADSTSVRRGAELFAENGCAHCHGTNGIGGGKGPDLNNVAHHMKPKEIATQIHDGGKNMPPYGDALSDQQVADLIDYLHSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E9</accession>
    <name>E8X6E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572945.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71033">
        <property type="protein sequence ID" value="ADW71033"/>
        <property type="gene ID" value="AciX9_4257"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4257"/>
    <dbReference type="HOGENOM" id="CLU_025336_0_0_0"/>
    <dbReference type="OMA" id="YPKYGAV"/>
    <dbReference type="OrthoDB" id="157489at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234441" evidence="2">
        <location>
            <begin position="25"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="782" mass="87101" checksum="017A675E4B267A5F" modified="2011-04-05" version="1">MDRRNFLKCAAASTAALGSLAAVAEAPKTVSCESALIGAMAAMDASVDGHTKLCTFARGDESWTVYEDLRTRDGVITFVSSKGVARVLPKTAEATFADDGPQHLGLDIKDIGMAGQDLLADKLLAHGDPNEDEVRRAAPPMNSMHRDGPNARPVWNTIVGTRECSDTMPVYPSGNTRTYHPVQYFKELTQDRANKRHEGLIGGWMPAVRKVLPGDDGSHYEIVVFGDVLAKDRFIVQTWHRTAHIQNGAISKVEYGYSYPAYTRRQQDPKPEEFYAGMLEFAEYWERQTHDVTPMTLPDTSWSDMVRYAFVKEQIVRPGGVYPKYGAVDRDYYGPEYDGFQDIFTMALYANLECGRFQVAHDIFDNYFSDFTNSKGMVNMRGAETAQFGLTLFLISRYYQLTGDRSLLLKHREKIEATATLLAELQDEALKLPTSDPGYGLLHGWCESDSCLMPDPSVWWKPYFSNSAFTVRGWRDIAGTWRKLKLSGAEPTAAEWMRRSQQLQDTLTKSIEANIRRDMKPAYIGPMPGVKLTFRESIETEHPSEQGWTHRCYAELLQPDVLPAEQANIVIDCMRAYGATTVGVVANVGRANPNGRAILGFVSYGYAAMLLRLNRIEEYILFLYAHRYHDHSRGSWTAGEVSGITGGGALFCIPAQQTIPLLVRWMMVFEDSDEEHLHFGRALPRDWVATGKPIGIVGAPTRWGRVDYRLETRGDALAAIITLPAKGDLPKELSVSFRPGTGKTLKDATVNGTAMPFAGPHNDAVVISPNGQRRFEVVAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I5</accession>
    <name>E8X6I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4301</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572979.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71069">
        <property type="protein sequence ID" value="ADW71069"/>
        <property type="gene ID" value="AciX9_4301"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4301"/>
    <dbReference type="HOGENOM" id="CLU_2034786_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230284" evidence="2">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="11596" checksum="5F7E5CAE1E0D5219" modified="2011-04-05" version="1">MNMKFTTTAVLALMLPFTAALAQKSVTGKRGGTASSSVTRTGGTVNASGTATGAHGNTVTGSGIATKTKTGTVDSGSITGPKGGTSTVSGTTTDNGATTTANGTVTGPRGNSRTGSVTVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K2</accession>
    <name>E8X6K2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71152">
        <property type="protein sequence ID" value="ADW71152"/>
        <property type="gene ID" value="AciX9_3870"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3870"/>
    <dbReference type="HOGENOM" id="CLU_2935053_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="7154" checksum="22812F063824E999" modified="2011-04-05" version="1">MVRGTKHTVEQIVNLLRQVEVGMAKGKALPQACRETGIVEQTYYRWRWWSAHRFLNQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K6</accession>
    <name>E8X6K6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71156">
        <property type="protein sequence ID" value="ADW71156"/>
        <property type="gene ID" value="AciX9_3874"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3874"/>
    <dbReference type="HOGENOM" id="CLU_527619_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="516" mass="58133" checksum="0E27D90D8B03D839" modified="2011-04-05" version="1">MFVDPLEAARYTCHFRTALAPGSLLTRARGLPDIGWTASDPQALSLPLSGQLASHSQLKIWIEKIGKAADHLYGVSVANPDPTEGAEAFFAWREKILEAFEARLVVTSVAEEIRATFHAQRDILVVDGHDLTELPVELQILRQNLKVLSLSNNRLSKLPDEIALLEQLTELDVSDNLLTELPPQIGNLSNLEMLSVGHNRLSELPPSIGQLTALRELRVNDNKLRKLPAEIGQLTKLRRLHLQQNRLTELPLEFTCLEALAEWNAKPNRLPPSGSDGLKAGQNPWIHPPEEIVRKGPKAIREFLTAHPRNVAAVDSNSVYTVYVDDNYHREQEQWKRRILGTFADCDAAIALCKKFVDDFFANFPAAPMRGLRGKNAADLVGVYYRYGEDPWICGDDPNCLFDAWNYAEQRCEEIAKTTRDNPPAAYTVYSCNNRDGSGIVKIGEFEDCESAVTLCRKIVDDFLLTQNSETAEDLFTAYRRFGKYAEVTTRDQACSFVPWDYAEQRCHEIMAERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M2</accession>
    <name>E8X6M2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3894</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71172">
        <property type="protein sequence ID" value="ADW71172"/>
        <property type="gene ID" value="AciX9_3894"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3894"/>
    <dbReference type="HOGENOM" id="CLU_175648_0_0_0"/>
    <dbReference type="OMA" id="QNCSRCH"/>
    <dbReference type="OrthoDB" id="2072269at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233748" description="Cytochrome c domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="101" mass="11145" checksum="401B7390FCE46F70" modified="2011-04-05" version="1">MRLLKFSLAVTAMMSSSVLLWAATQSQAAAGQAAKKPVTTSRPAQQPQDDGDQIFQQQCSRCHNAPEGFSPRISGTIARHMRIRASLSKHEEEQLLHFLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T5</accession>
    <name>E8X6T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3959</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71235">
        <property type="protein sequence ID" value="ADW71235"/>
        <property type="gene ID" value="AciX9_3959"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3959"/>
    <dbReference type="HOGENOM" id="CLU_551820_0_0_0"/>
    <dbReference type="OMA" id="AYWVQGF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="494" mass="54536" checksum="F6760D3064BB7CD3" modified="2011-04-05" version="1">MSTRAMTIPDVMTGAPREPAAYSLLRAKRFWVVLLTIGFWFARPYYFPLNAMEERNADAHAIVEQASLTRQISLPLMGLVACYMLWRIPRRRRAQGFHGALAIAAGAYFALAVGSLLWTADPALGLKRLTVFFLDVLLVIAVAKSFRVIELAKLGFFACGSVALIAFCVDVFVTHTFAPFDPDYRLLGVMSGNSQGMNITVFMFCGLTLLLKYPQRTRSLTAALVAGAILLFYTHSRAAAGACVVMSLFFFKQIIDTRVQRRSNVVALFLLFACVLPAIIATGSGERVLQTSFMMGRSDTENTATVSNRTPLWADVSDFISERPLTGYGFHAFWSTDHISTISKHLGWVVPNAHNTYLDETLSAGVGGALLYAFLLWGSLVVAWKRYRRNAGPETIFPLAMLGWIFITGWVESVALDPFLPTFLAYVCLAQCMLPESPYRRREVVVEEAVLGTHPGFARLKPAGAVMAKKDAVRLPAALRRRLAQPHSPDESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T6</accession>
    <name>E8X6T6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3960</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582254.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71236">
        <property type="protein sequence ID" value="ADW71236"/>
        <property type="gene ID" value="AciX9_3960"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3960"/>
    <dbReference type="HOGENOM" id="CLU_028014_5_0_0"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45590" checksum="306AB0702715DC58" modified="2011-04-05" version="1">MRVVFVTREPIIHQFGGSTTAALNLLEVLVAQGCQVDMLVTDPYSRSPRLFWRQRLPLPAGITLHLGKPGIGTLHLNPFSLRAWARFAARLAKRFQPLAWLGGLVHLLFGNKVVADAWDLTPPTQQELAAALAFIAAQNAEIVVVNYAFWGSLLSAPALHAHKRIILMHDMLSARAARFQQAGLALDCIPISHDEEISWLNQADIVLAIQNAEAEAIRPLLTAEVLVQPIVLSLRPPKPPPLPNPNHCLFIGTRIQPNQTGIQWFLDEVWPLILTANPAATLTVAGSVCEVIEPGAPHVTLAGILPSLAGEFASAAVCIVPLLVGSGLKIKLLEALAQGKACVSTPIGVQGLEDAVEGVIEVAGNPADFAAAVLRLMQDQDLRQAREQASLSLVRRRFRPESEAARAFAAKLLATEPRPSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U7</accession>
    <name>E8X6U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase like protein, AhpD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3973</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582265.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71247">
        <property type="protein sequence ID" value="ADW71247"/>
        <property type="gene ID" value="AciX9_3973"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3973"/>
    <dbReference type="HOGENOM" id="CLU_082760_5_2_0"/>
    <dbReference type="OMA" id="NNFWRAL"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="14395" checksum="A56A4DDA5E5F26EE" modified="2011-04-05" version="1">MGTVRLWTDEEAASDARVAAVFADIRVMRGSDFINNFWRALANQPAALERTWAKLKVVMMEPGELDPLTKELIYIAVSTVNGCGYCVHSHSAAARAKGMTEGQHGELLGVIGMAMETNALATALQIAVDGAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W1</accession>
    <name>E8X6W1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3987</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582279.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71261">
        <property type="protein sequence ID" value="ADW71261"/>
        <property type="gene ID" value="AciX9_3987"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3987"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="MTIRGGF"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="576"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1152" mass="123971" checksum="A8B54EE142DD0AC5" modified="2011-04-05" version="1">MRSFGPGKSIRNVATVFALGVGFAHGQATNSGDIRGTVTDPTGALVPDVVVTVTNVNTGVTKILKTNQDGLYDTSSIVVGTYSVTFERPGFEKYSRPQISLQVGTSTVNAIMKVGSATDQVVVNTDLPLLDTETGTQQTTFEAKSMELLPNVGQDWQNFAILIPGSAGLAGGTNPGQSISANGNLPYSNILADGASTTLGTSSNSDVNTFETVQEVQISTSAFSAQYGIGGIIFNQISKGGTRQFHGAAYDYFSSSQFNANSYQFAGQSNSLAFDRRNNFGASVGGPVAIPFTNLKNKAFFYFNYDQIVDHGSASGTNDIPSTAVMGGDFTGQSLIYDPTTQTMAKDSKGNSYPVRKSFLSEYGFNAIPTSLFDKVSANFQKFFPTPANHIVGGHFQAGQTNGQGILQRNFYASVPQSNPDKKYFGRLDYDISPSNRLTFSVTQGDNSALYPNTVTAQPIGASAGDISRLNSQVTDVWNINDHFINEARFGFTYQGNFFSDQTFGKGYPAQLGFQFAQADEIPGVQFITNYPYAWIQPESSQFIYKENVFDPSDVVTLIRGKHVLHFGGEVGIYRNDNTPYAQINPGTFQFSGQYTQNWAVNGQGVAAPDSNTGADYADFLLGDALNWGAQNGSEYGARLKNPQVFIQDDYKIRPNLTLNLGLRYQVRLGINEVHGNVGTFDPTIVNTANGQLGAYWYGQTHANGRTSLQDSKYSTLLPRVGFAFLPTPNMTIRGGFGVYAYNLSLDTYGGGLGNVNTQSGNYQDPTNGITPGIIFSGPGTENLTGTPLPFTKAGTSPTRFNGQSAGYTAYHTPDPKIYQWNFGIQQAIGTNMVFELSYVASHAFNLNFPTDINQVPTALLAQNDSQSRPNHNYTSINGSTNDAISNYNSLQTSINRRLASGLSLNFNYTWAHFLDDQDSSGMGSKAGPISRQFADAPSNYSNSNFDIRNSFKGRIVYQLPIGRGRAFLNHNWLVDELLGGYQVSSTIQLTSGNPFSVFASNQHSYDEPGQSDDPFPNYSGAPLTPAGGHSTFEWYNPAAFTLPAPGTFGNVRRNSVYGPGSELVNLSAGKKFDIHESVKLQIRLDATNAFNHANFGQPNGNLGTCSGPPNCAVAQQAGQAFTQSGSFGAGNNQITGAGGGRSLQGGIRLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X734</accession>
    <name>E8X734_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4309</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572987.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71268">
        <property type="protein sequence ID" value="ADW71268"/>
        <property type="gene ID" value="AciX9_4309"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4309"/>
    <dbReference type="HOGENOM" id="CLU_1765457_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="15822" checksum="6D5DE015A7D98730" modified="2011-04-05" version="1">MQIHIFVGALSFCIFSLGLFLGAGVRPLLMPAMKSDPALIGPIVTGMFSRYNVLALALSGVSLILELMSSSSRTERFILIGLTLLLALKVAFDSVIKRREGAAQIRGRGEEGMQLDLLHQIVEKATLVIIVLSLGSFILSLLQVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X751</accession>
    <name>E8X751_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4332</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573004.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71285">
        <property type="protein sequence ID" value="ADW71285"/>
        <property type="gene ID" value="AciX9_4332"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4332"/>
    <dbReference type="HOGENOM" id="CLU_012817_10_1_0"/>
    <dbReference type="OMA" id="SQTIWDS"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234476" evidence="3">
        <location>
            <begin position="35"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="55620" checksum="D22474560F55F0D6" modified="2011-04-05" version="1">MFRLPHSSIQRVALVKLSAALLLCAGLRALPAQSPSEMPVEPTRAVQLPLSGRSSQAGDVTVMQRTTNSGGGNSVVTIDSSVTVPVPYSGSVPTGVASPDVLPLTLESALAMGLRTNLGALSQSAATEQAQGQRAVAKSQLLPQVNTVVSEVFEKENLRTLGVSLPSIPTTSKFNYYDARAVRLQQSLFDLVRIRNVQGASENVQANIKAARNTRDLIVLAVAGSYLQLLATRARVEASDSQVKTFRAIYQQAADRRAAGLATRVDADRSLVQLQTQQQRLRSLKADQQTQSLRLARIIGLPLGQRFTTGEQYAFTPVTLVLEEDALKRAESERSDLQAAASDVRAAELAVKAAHAERLPSLGISADFGAAGITPTNHSTSVYTVSGTLTVPIYEGGRIHGEIVQTKAVLRQRKAEFDDLRGQVDEDVRQAFIDLDSAADQVGVAQSNATLARETLEQSRDRFTAGVADTVELVQAEQSVVQADDDSITAVFEHNLAKVALARAMGNAEQTLPQLLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X781</accession>
    <name>E8X781_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4363</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573034.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71315">
        <property type="protein sequence ID" value="ADW71315"/>
        <property type="gene ID" value="AciX9_4363"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4363"/>
    <dbReference type="HOGENOM" id="CLU_117621_0_0_0"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="8977" checksum="1AFFAF65CEA5D872" modified="2011-04-05" version="1">MAQYVGEVKWFNNAKGYGFLGREGGPDVFVHYSSIQLDGYKTLKEGDPVEFDIIQGNKGPQADKVTRIGSSPTQQGLSLVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E7</accession>
    <name>E8X7E7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA topoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4434</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71381">
        <property type="protein sequence ID" value="ADW71381"/>
        <property type="gene ID" value="AciX9_4434"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4434"/>
    <dbReference type="HOGENOM" id="CLU_905828_0_0_0"/>
    <dbReference type="OMA" id="PCAVVET"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039459">
        <property type="entry name" value="RepB-like_DNA_primase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16793">
        <property type="entry name" value="RepB_primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepB_primase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="28782" checksum="1E7A569F4B061B02" modified="2011-04-05" version="1">MLPGLDGITATNLIERLSLLKYRNARGSHIYIRPSGEHRYTALDDLSEVSLARLAADGFAPCAVVETSAGNFQVWLKHPAVFPKLLGTFAAQTLAARYDADPSAADWRRFGRLPGFTNCKPKYKRPDGLFPFVHLRSNTGGQYPMAETFVREITRLYEAREQEREARRLQASLSPQRGPRLSNLSLERFRTSSKYQDRPAAADIAFCVAAYANGMDEARIERALEDDYLSCDPSPSKRSSYIRRTMTKARDWAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X1</accession>
    <name>E8X7X1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4625</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573274.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71555">
        <property type="protein sequence ID" value="ADW71555"/>
        <property type="gene ID" value="AciX9_4625"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4625"/>
    <dbReference type="HOGENOM" id="CLU_158535_0_0_0"/>
    <dbReference type="OrthoDB" id="1702091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14898" checksum="F6D0DC82FA0E64AB" modified="2011-04-05" version="1">MSELHAMQVSDLDSRLRRSKGRLARRCGANVKLTPDELAELEAVAKHHGKALGEWGREELLAAARRPKDDILLTELIGLRMFLVNLLRPIALGEDYTDEQFRALLDHVRAEKRSVTSQVTEQYRHDQKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z6</accession>
    <name>E8X7Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573299.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71580">
        <property type="protein sequence ID" value="ADW71580"/>
        <property type="gene ID" value="AciX9_4650"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4650"/>
    <dbReference type="HOGENOM" id="CLU_053673_0_0_0"/>
    <dbReference type="OMA" id="VEFISIM"/>
    <dbReference type="OrthoDB" id="1022151at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019219">
        <property type="entry name" value="DUF2130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09903">
        <property type="entry name" value="DUF2130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="464" mass="52320" checksum="389AE2585A05760D" modified="2011-04-05" version="1">MSNLSSASAAQPAIACPKCGTPVLLTEALAAPLIEATRAEYEAKLRSHSDAVAKQQQELTRKEQATQEVEQQLAKREADIKRRYEEARAEIGTQREQLAAEVTRQTEVAVTKELAERLIVERKTIAEAEESRARQRFADELAERDRDRKEQGEYIERLTAKLTAAQTAEVELKRREREFDDKERELPLRIEQEVSGRLDQARASAANEASERLTLQLSEKERQIKDLATKLEEASRKAQQGSQQSQGETLELLLEDQLRRQFPFDELQPVPKGEFGGDTLQVVRDSSGRECGRILWEFKRTKIWQSAWLSKLKGDQRSARADIAVIVSQAMPPDVRHFNEVDGVWVSSLGCTLPVATALRASLLQLASQRRSAEGQHTKSELVYAYLTGSQFRGRIEAIAERWSEMQKDLADEKKATMKRWSKREAQLHTLLDSTAGIYGDLQGIVGRDLAEIEALGETLLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X817</accession>
    <name>E8X817_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4671</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71601">
        <property type="protein sequence ID" value="ADW71601"/>
        <property type="gene ID" value="AciX9_4671"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4671"/>
    <dbReference type="HOGENOM" id="CLU_846660_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="328" mass="35675" checksum="E1F298C5AEFDC9EE" modified="2011-04-05" version="1">MTGEYKIRNLAKTAIVGSFYPLGRGRNHRRFRKPRLSVNGDFSVGSVEGGLQPESLGGANIVDMAGHRKTGALLVALLSLFLTNSRAQVRFGYSGGLAGEASADIDQELKLGSPDQREGLLKLLGVDGAIAHDAAAAVPNSNIHIEPIVGSEGRLLFFPCTGPGSPSSHLYLLRTTKEHRWHVVAGERFDCWWKPTSYELIKTEGKVDQSVLIHHVNRGHGSGIVEDHMLLFEVRGNLLANVLETKEYTSEDRMAEGPIVQHSSTLLPLPDGSIEETRITTTVGSSTKGGKSETAPVMQSHIALAERRRWRWSAGDKHYVDGSFAPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB3</accession>
    <name>E8WVB3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0214</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578616.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0214"/>
    <dbReference type="EnsemblBacteria" id="ADW67288">
        <property type="protein sequence ID" value="ADW67288"/>
        <property type="gene ID" value="AciX9_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0214"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_3_0"/>
    <dbReference type="OMA" id="IVGEEWS"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015171">
        <property type="entry name" value="Cyc-maltodext_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09087">
        <property type="entry name" value="Cyc-maltodext_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234075" evidence="1">
        <location>
            <begin position="19"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="119"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="607" mass="66893" checksum="007243643283A5A7" modified="2011-04-05" version="1">MHAFLRLTLLAFALPLAAQQPHIDKVDPPNWFAALPSPMLLIHGTGLSGATFTGAPSTHTVTSPNGHWAILELDTHAIRPGTLHLTAHTSSGTVSFDYMLSPRRTEGISGFSPADVITCIMPDRFADGDPSNDNLPGMPPIDRANPHAYHGGDLKGVIDHLDYLQQLGVTAVWLTPIVANNPAGRDYHGYGATDLYAVDPRLGTLADYQRLTTDLHRRHMKLFFDDVPNHFGPKHPWALDPPLPDLFHGTPADHQEAKYDFNRIMDPHYPESAANLELNGWFANVLPDLNQQNPFVAQYLLQNMIWWIEQTGLDALRIDTFPYVQRTFWQGYLSALQNIYPRLNFVGEVDNGDTNINAYFAGDRKIAGIDTHLTTPFDYPYFFALRNVLIKGESFEALETTFRQDWLYPHPELLVPVLDNHDNARFMSEKGATPELMRIATGITMTVRGTPQIYIGDEILMQGGEDPDNRRDFPGGFPGDPANAFTAAGRTPAQAKLHDFTALLGQLRAHSPALQGGQQQDVLVDKDTFAYVRTPANANSACSSLARGQSLLIAVNRASTPSTLTIPTQATVLEGCSKLSPILGDGTPQSSFTLTLPPFGFAVYRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE9</accession>
    <name>E8WVE9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1337</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1337"/>
    <dbReference type="EnsemblBacteria" id="ADW68397">
        <property type="protein sequence ID" value="ADW68397"/>
        <property type="gene ID" value="AciX9_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1337"/>
    <dbReference type="eggNOG" id="COG4986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_0"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="OrthoDB" id="1065003at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="384"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="590" mass="64773" checksum="FA53A257E15D90AC" modified="2011-04-05" version="1">MISLPTNLPTRETLARSQVLRRSWPFVMDLAVAVIGLAVFYCIVLIAKFWAGPPNTQMVVSLSPRALPAYAFYSVVRIGLAYLLSLAFAIAYGYTAAYNTRIEPFMIAVLDILQSIPVLSFLPGVMLAMVGLFPTRHLGVELGAIVLIFTGAVWNMAFSFYSSLKSIPRELIEATRVYRYSPFQRLVQLELPYAAIGLLWNSIMSVAGAWFFLMACEMFHFRSQDFRLPGLGSYLQTAADQGNGHAIAWGLFTMVAIIVATDQLLWRPLIAWSDKFKFEQVESSKRVASPILALLTQSNALTALKEHTTEPLTEYVYTRYAERRIAILKRQEGRPPAAPSKSANLLAYALIAIAAVVVLYLARQTLILISPLQRSQYLELLKGAAATFGRVNLSLALAAAWTIPVGVAIGFHPRLARIAQPLAQIAASVPATALFPVILLALVRIGGGLGIGSIALMLLGTQWYILFNVIAGALAIPTDLKEVATLFHFSTLQRWKTVILPGIFPFLITGMVTASGGAWNASIIAEYFRLNNQTLQTVGLGAMISNATEQGQFPILLLGTVMISLMVVTTNRLVWRPLFRLAETRYRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ7</accession>
    <name>E8WVJ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase and fumarate reductase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1386</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579767.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1386"/>
    <dbReference type="EnsemblBacteria" id="ADW68445">
        <property type="protein sequence ID" value="ADW68445"/>
        <property type="gene ID" value="AciX9_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1386"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_0"/>
    <dbReference type="OMA" id="CPKGISL"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="251" mass="27137" checksum="77AC284205F16965" modified="2011-04-05" version="1">MATATRTIEVHIKRQATPDAPARTEKFSIPYRPNMNITSLLGEIAAEPVTASGQQTTAIAYDANCLEEICGSCAMLINGKARMACSALVDKLEQPITLAPLSKFPVVRDLAVDRSVLFQNLKAVKAWVPIDGTYDLGPAPRQFPQIQESRYPLSNCISCTICMEVCPQFNDSTNFVGAATIAQVKLFNMDPAGAVLKEERLRALAGDGGVQECGMAQNCVAACPKQLPLIEAISDVSRDVVIQQVKDFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX2</accession>
    <name>E8WVX2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3730</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582040.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70731">
        <property type="protein sequence ID" value="ADW70731"/>
        <property type="gene ID" value="AciX9_3730"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3730"/>
    <dbReference type="eggNOG" id="ENOG50330IW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158041_1_0_0"/>
    <dbReference type="OMA" id="LAFGMWE"/>
    <dbReference type="OrthoDB" id="2041697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031796">
        <property type="entry name" value="DUF5076"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16826">
        <property type="entry name" value="DUF5076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11293" checksum="B30B81951FCC70C1" modified="2011-04-05" version="1">MGQEKQLEIPAAAAKDAASFELLRLWVANQSQQISLRPGVWQDPTAWGVMLADLARNIVQVHAENDEDLDAGAFLGSLLEGFDNEIEDVLNEFEGDESEHEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY3</accession>
    <name>E8WVY3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">AciX9_3741</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582051.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3741"/>
    <dbReference type="EnsemblBacteria" id="ADW70742">
        <property type="protein sequence ID" value="ADW70742"/>
        <property type="gene ID" value="AciX9_3741"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3741"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095354_0_0_0"/>
    <dbReference type="OMA" id="VAHIMQP"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="19768" checksum="733B733D87CF13FE" modified="2011-04-05" version="1">MPTTESYQLLLAAAAACEDKKAEDIRILALDPSESGLTDYFLICNGTNDRQNVAITDAIEIKLKHEFGTYPNSVEGRRQGEWILMDYVDFIVHVFSAEKRAFYGLERLRKSATTISVPELNAELKALIAKTRTKTGKSAKVAEPAEAAPVKSAAKKIVAKKAVAKKAVAKKAAAKKTTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW00</accession>
    <name>E8WW00_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578634.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0232"/>
    <dbReference type="EnsemblBacteria" id="ADW67306">
        <property type="protein sequence ID" value="ADW67306"/>
        <property type="gene ID" value="AciX9_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0232"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_0_0"/>
    <dbReference type="OMA" id="VLFHNNA"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26316" checksum="C76D3897ACD3A908" modified="2011-04-05" version="1">MPSSDSLLQLSAAILSASGLAIGAAAYAMLYPQSQLCGPVLIAPPQPQQIALTFDDGPNPAATPQLLEALAAHNIRATFFLIGAHVLREPALTRAIAAAGHIIGNHTMNHPWLHLLPESRIRTEISDCNRALEDTLGRRVRLFRPPHGARRPAVLRIAREHNLDTVNWNIIVKDWLPTTPEVLLARMEKGILRNRTQGHASNIVLHDGGHAQPRLPTVEAVTQLLNRHQGATYTTPEAWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW14</accession>
    <name>E8WW14_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0246</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578648.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0246"/>
    <dbReference type="EnsemblBacteria" id="ADW67320">
        <property type="protein sequence ID" value="ADW67320"/>
        <property type="gene ID" value="AciX9_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0246"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_0"/>
    <dbReference type="OMA" id="LPRGRWY"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233911" evidence="3">
        <location>
            <begin position="25"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4968" evidence="5">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="4">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="6">
        <location>
            <begin position="712"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="829" mass="92003" checksum="7EB4AC6779F27395" modified="2011-04-05" version="1">MSKAKVLQSVFCGFGLAGLLVVGAAGQDITPDASGLLARAGGVRLQVNALRDDVIRVRMWKGDARPEDASWAVIGHGKVPVTAEAKGFATKDLRISVDERLMLTVSDLQGNVLQKDAAPVAWEGNRFTVSKQRGFDDHFFGLGDKPGPLDRGGQAFTMWNTDSFGWQESTDPIYKSVPFFMDVNKGRTLGVFLDNTWRTSFDFGRADEKRYTFGSLDGPLDYYLMYGPEAKEVVKTWAWLTGPTPLPPMWALGFQQSRYSYFPESQLREVADRLRKDRIPSDVLWLDIDFQHKNWPFTVDEQGYPNFKGMVKDLADERFKLVVITDLHVAKQAGVGYAPYESGTAGDHFVKNPDGSTYVGVVWPGPAVFPDFTRKQTRQWWGTLYKGFVADGVAGFWNDMNEPAVFDGPGKTMPDTVQHRIDEPGFKPRTATHLEIHNVYGMENSRATFEGQLALRPNERPFVMTRASYAGGQRYATTWTGDNSATWNHLRMTVPQLVNLGLSGFSLAGADVGGFAGSPPADLLTKWLEISAFQPIDRDHSAKGTRMHEVWVDGPEQEAIRRRFIEERYKLMPYLYTVAEETSRDGVPFNRPLFLEFPRATADGSPYDLTTGGGEFMVGERLLVAPNPSPEEVAPYTIHLPPGTWYDYWTGEQTTRAGAVGTLDLEQRDKVIAQKPLLVTPKLEELPVYVRGGTILPIAPLTQNTAEVPNGPLTLRVYPLAAGLNTPGESCSGEVYADDGHSFDFKRGEFARVKFSCAVGADGGLTFEVAKQEGKWKPWWKEYRVEVVGWTPGKNEATFNGKGLKMTQVDGRWGVTVPANGAAGRVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW35</accession>
    <name>E8WW35_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface exclusion protein PrgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0267</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578669.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0267"/>
    <dbReference type="EnsemblBacteria" id="ADW67341">
        <property type="protein sequence ID" value="ADW67341"/>
        <property type="gene ID" value="AciX9_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0267"/>
    <dbReference type="eggNOG" id="ENOG502ZQJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2508068_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234095" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9169" checksum="235F7FAC13FA232D" modified="2011-04-05" version="1">MKLHATATALLFASLALTGLAQTPVPSNTQDTKITKSDLKQQEKANKSQAKADKAQRKALNTKQQKKADKAQDKANREAAPLSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA1</accession>
    <name>E8WWA1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase AAA-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1426</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579806.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1426"/>
    <dbReference type="EnsemblBacteria" id="ADW68484">
        <property type="protein sequence ID" value="ADW68484"/>
        <property type="gene ID" value="AciX9_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1426"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="OMA" id="GRVIQEH"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="821" mass="92757" checksum="4CB36B3FA3C0775A" modified="2011-04-05" version="1">MFERYTEKARRVIFFARYEASQFGSPYIETEHLLLGLLREDKALTNRFLRSHASVESIRKQIEGHTTIREKVSTSVDLPLSNECKRVLAYAAEEAERLSHKHIGTEHLLLGLLREEKCFAAEILQERGLRLPAIREELQRTTQEKPAAAAAKAARGEQSMLAEFSRDLTQSAMDQQLDPLVGRDTEVDRVIQILCRRTKNNPVLIGEPGVGKTAIVEGLAQKIADGEVPSFLADKRVLALDLSLIVAGTKYRGQFEERLKTIMKELMENQNSIVFIDELHTLVGAGSAEGSLDAANILKPALSRGEIQCIGATTPAEYRKSIEKDRSLERRFQAVKVPPPNEEDAVKIIMGIKEKYEKFHAVSYTDDAIQFSVSHSSRYIPDRFLPDKAIDLIDEAGARVKLRQTSLPEELTEVQKRIKFIVHRMENAIANHEFEKARFYSDEERKERENLRALRDKYHLDDSSAGIVTREDIEDVVSRWTGVPMTSLKEEETERLLRVEEELHKRVISQDKAISALARAIRRSRAGLKNPARPIGSFLFLGPTGVGKTEMARTLAQFLFGSEKSLIRFDMSEFMEKHSVSKLIGSPPGYVGYEEGGQLTERVKRNPYSVVLLDEIEKAHPDVYNLLLQVFEDGQLTDGLGNTVDFKNTIIVMTSNIGAKHLQKQQGLGFQASDENMVLDKMEELVRGEVKKTFNPEFLNRLDEIIIFTSLVESDLMQILEILVQQLNTNLVHKAITISVNDDAKKYILQKTASDRTYGARPLRRALQRFVEDPLSEALIAGGIKERPAFLEVYLENNQLFYRPILADTEEKAAGLALTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA8</accession>
    <name>E8WWA8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1434</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68491">
        <property type="protein sequence ID" value="ADW68491"/>
        <property type="gene ID" value="AciX9_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1434"/>
    <dbReference type="eggNOG" id="ENOG5033VZV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2861457_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="6569" checksum="E51D53CF7E6F557A" modified="2011-04-05" version="1">MGTFKTFAVYASAVICFGGLIFAGIRMMSGRFQDAIPGLFGALFGAGVLGWGAGWIGSLTGQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC1</accession>
    <name>E8WWC1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1451</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579825.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1451"/>
    <dbReference type="EnsemblBacteria" id="ADW68504">
        <property type="protein sequence ID" value="ADW68504"/>
        <property type="gene ID" value="AciX9_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1451"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_5_2_0"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18918" checksum="32A0F03E0E66D73F" modified="2011-04-05" version="1">MYNHVIWPHRFDPKTSAIYALNDIDVKAPPEMIWKLLVDAEHWSSYFPAENQVKILSGEAELELGTKWTRMTVGIPTRLIVTEYEPNTRLSWSTTVDGDETGSSAYHGWVITPTDRGCHVLSEETQQGPYFLEALGRKHPGGLYSYHQEWVEKLARAAEAEAAKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF1</accession>
    <name>E8WWF1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2590</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580930.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2590"/>
    <dbReference type="EnsemblBacteria" id="ADW69615">
        <property type="protein sequence ID" value="ADW69615"/>
        <property type="gene ID" value="AciX9_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2590"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_2_0"/>
    <dbReference type="OMA" id="IYVRGFG"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="11790" checksum="3BC35873244A0AF0" modified="2011-04-05" version="1">MTKADLVDKVTSLGDLTRRDGEVIVDLLFDSVIGALKSGDKIEIRGFGSFRTRQRNSRIGRNPKTGAKVDVPAKKVPFFKPSKELRDLVNPKGLLNGAAVNAHHPPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ4</accession>
    <name>E8WWQ4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_0310</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0310"/>
    <dbReference type="EnsemblBacteria" id="ADW67382">
        <property type="protein sequence ID" value="ADW67382"/>
        <property type="gene ID" value="AciX9_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0310"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_1_0_0"/>
    <dbReference type="OMA" id="GWEACGT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="611" mass="66897" checksum="D853BFAFCB4DC64A" modified="2011-04-05" version="1">MKKRSTPSMPTPTSQAPVVTAPDLSSRSIAYFSMEIALAKALPTYSGGLGMLAGDTLRSAADTGAPMVAVSLVHRRGYFKQFLDANGQQTETDVPWSPDTLPTAGETVSITMQGRTIKICAWRFDVVGVAGHIIPVFLLDTDVEGNDPFDRRLTDHLYGGDTYYRLCQETVLGLGGVTLLHKLGCEPAVYHMNEGHAALLALGLLEDRLAPGAALSTATENDRLAVARQCVFTTHTPVPAGHDQFGLDQMYAILGQERGKALERFGCLHNNLLNMTYVALRFSRWVNGVAMQHGKVSQQMFPDYHVESVTNGVHAATWIGPELQNVLDEEIPRWRHDNQYFRSVYGIKPARIANAHACNKRKLVEEIAARTGEHFDQNVLTLGFARRVATYKRASLLLEDPKRLLKIAQKIGGLQIVFAGKAHPADAAGKGLIREVFEIAGKIKSNSLRIVYLENYDWELGATLTQGVDVWVNTPRRPYEASGTSGMKAALNGVPSLSILDGWWIEGCAEDVTGWAIDDGDTDAAEATSLYDKLEQRIAPLFAKPNSWARMMQHCIAMNGSFFNTDRMLGQYFANAYFPQAPAADATPETESEAEGMAISTSPKLQEPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS2</accession>
    <name>E8WWS2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0328</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578728.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0328"/>
    <dbReference type="EnsemblBacteria" id="ADW67400">
        <property type="protein sequence ID" value="ADW67400"/>
        <property type="gene ID" value="AciX9_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0328"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061791_0_0_0"/>
    <dbReference type="OMA" id="VIWASHW"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="33799" checksum="0DCB99CABD90426A" modified="2011-04-05" version="1">MTIELNGADHFELLLQEVLYETANPQPPLHIESRIHAALSLQPVPERGPAMVNSAPVLQSQSILWDGPSASPWNVRGLVGAAFIHALAIFLIVFAILHRTQLVASVHTPQVAILTVPPLPPIAPRTLAAGGGGGNVSSTPVTRGNPPKVAPIQIMPVKAPPLEQPRIALEPTVVAQADLKMAHSDVPQIGMPNSPLVGMSFGNGRGTGLGSGDGAGIGPGSGGNTGGGIERIGGGVSAPIVTFQPEPEFSDEARKAKVGGNVLVYLQVDESGHPINVRVLRGIGMGLDQRAVAAVQQYRFRPAMKDGHPVRIEMNVEVNFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT4</accession>
    <name>E8WWT4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">AciX9_0340</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578740.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0340"/>
    <dbReference type="EnsemblBacteria" id="ADW67412">
        <property type="protein sequence ID" value="ADW67412"/>
        <property type="gene ID" value="AciX9_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0340"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_0"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="137"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="372" mass="39652" checksum="45BF0EC422B43167" modified="2011-04-05" version="1">MAKKKLRVGVLFGGRSGEHEVSLLSANSILKAIDRKKYEVVPIGITKQGRWLGGDGAKGLLTGDSGLTLSASAQVTETGLIEQSGGVIGALDVIFPVLHGTFGEDGTIQGMLELADLAYVGSGVLGSAAGMDKDVMKKLFAAAGLPQTPYLSVLRSEWKADAKGCRKRIEKALEYPLFVKPANLGSSVGISKVHGRDELAAAMDLAAGFDRKLVVEQGVGGPGAKPRELEVAVLGNETLEASVVGEIVPAKEFYDYEAKYQMNGPDESVCIIPAKLSASEQKQMRAMAMEAFRACDCSGLARVDFLMEPAAKGKKAKFYLNEINTMPGFTSISMYPKLWGASGVGYTELIDRLIVLAQERHAEKMATAFARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT9</accession>
    <name>E8WWT9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0345</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578745.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0345"/>
    <dbReference type="EnsemblBacteria" id="ADW67417">
        <property type="protein sequence ID" value="ADW67417"/>
        <property type="gene ID" value="AciX9_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0345"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_2_2_0"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="29035" checksum="A6B194EBEDABA206" modified="2011-04-05" version="1">MHEDLQKLMALQALDLEAKKLRDEMAALPKHVADLDTKAKAIAGQRAVVLDLIAKEEALRRRQESDVKDQQAKVAKGKQKIGNAINTVQVTAFEHEIAFAEKEISRLEEAELESMMRSEELDAQKTVADKALTAAESTHKSERERAIATIAADKIAVAAVDVQRTAQRATIGEDALSLYDRIAKAKGTGIAEALNQKCTACQMMLRPQRWNDIRERDHTEMTTCESCGRLLYYDPARDSPQRKTVTPERTESIAAQIVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV9</accession>
    <name>E8WWV9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0365</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578765.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0365"/>
    <dbReference type="EnsemblBacteria" id="ADW67437">
        <property type="protein sequence ID" value="ADW67437"/>
        <property type="gene ID" value="AciX9_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0365"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595599_0_0_0"/>
    <dbReference type="OMA" id="PLMERYH"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="231"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="45978" checksum="1B0A0ED9D3A7F3D9" modified="2011-04-05" version="1">MAEVQREGMYLVLPVPFRVVNGEYFVEAQAANGLDRWADHFERLVVAAPVIPEEMVARLSGFVWRSLSTLEHRTRVMVQALPWAYSPGTFLREMRRVRQMMAASIAGAEHLQFAIGGLVGDWAAVAALEARKQKRKYAIHTDRVEHELIRKTAKGASLMRRLRVMVEAPLMERYHRWVIEGCSLGLWHGDDCYRAYAPWCDESHLVHDVHTKANDLIGAVELVQKLEDLEREGALRVVYAGRLDPMKAPLEWVSAIGAARDGGVELEAVWYGEGAMLDDARRESVRVGLERVIRFGGFVADRAAMLEHLRGAHALVFTHVTPESPRILIEALVSGTPILGYANAYAKNLLAGKGGGELVEVHDTGGLGALIAEMARDRTRLRRLTLEAAANGRRFTDEAVFAERSKLVKRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX19</accession>
    <name>E8WX19_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1527"/>
    <dbReference type="EnsemblBacteria" id="ADW68580">
        <property type="protein sequence ID" value="ADW68580"/>
        <property type="gene ID" value="AciX9_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1527"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_4_0"/>
    <dbReference type="OMA" id="HRWLLKM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="35879" checksum="78FDEAE54B88D70E" modified="2011-04-05" version="1">MPIMMERADQRRDYKERIAGAFRIRKERVLLVPSLARHQIAITRLTSEPGSPDRVMRLTSEQAFLLLVDLAPMPGAQTPAGGLAILDLSLQAELHVPSGSDRVIYHLPRTTLNALADESGMPRIGMLRMVDQVADPVIRQLTQMILPFLDRPADCCDVVLDSFQRTFCGYVLKTYSAGQTVELLQGGLAPWQKRRVLQLLHQDLGTALPLVKIASECKLSVSQMTRSFKKSFGHSVHRYLLLQRVERAKAMLSHGIDPLPEVALRSGFSDQAAFSRTFGAIVGTSPGRWRRERSVRSRATHASSYVQLARHESTTEFAPPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX45</accession>
    <name>E8WX45_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2663</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581002.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2663"/>
    <dbReference type="EnsemblBacteria" id="ADW69687">
        <property type="protein sequence ID" value="ADW69687"/>
        <property type="gene ID" value="AciX9_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2663"/>
    <dbReference type="eggNOG" id="COG1416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127515_4_1_0"/>
    <dbReference type="OMA" id="FVACHAS"/>
    <dbReference type="OrthoDB" id="1829042at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233451" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="16742" checksum="983C3E0F8C7C199D" modified="2011-04-05" version="1">MSIGKKILPFSLMLALPFCCTINGQAQAAAAPATTTAPAPSQATGKPHHVLVAVTSGDEADWNLALGNIRNLLKGLAPDQVDVEVVAFGGGIMLVAKPSTADADIQALMAKHVRFVACQNSMHARKLTEADLVTGVGTVPAGIVETVLKQEQGWTYIKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF4</accession>
    <name>E8WXF4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0415</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578815.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67487">
        <property type="protein sequence ID" value="ADW67487"/>
        <property type="gene ID" value="AciX9_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0415"/>
    <dbReference type="eggNOG" id="ENOG50323H2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103322_0_0_0"/>
    <dbReference type="OrthoDB" id="1406752at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21502" checksum="0CAB4AA93CB5FB50" modified="2011-04-05" version="1">MSKTPSYIDRSSLPASFPTNSHSPIFWEQLGRTIATFGFLEEILGKAIFVLTGTRSYGESEIEDAFENWTIVLEKALSDTLKPLAKTYGQALKSHHDPTPQNIDGLIQKIEDAADIRNILCHASWHIPDADGRSLPFFVNRRKEVVTMKLNTLGLLQIQEKVVELACDVIDTITQMGFQFPGSGGIGEKLWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG7</accession>
    <name>E8WXG7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nmad2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0428</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578828.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67500">
        <property type="protein sequence ID" value="ADW67500"/>
        <property type="gene ID" value="AciX9_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0428"/>
    <dbReference type="HOGENOM" id="CLU_1458719_0_0_0"/>
    <dbReference type="OrthoDB" id="1847290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041180">
        <property type="entry name" value="Nmad2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18753">
        <property type="entry name" value="Nmad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nmad2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="23431" checksum="D84D7785E75D8BA1" modified="2011-04-05" version="1">MPRTYLYKLTSDRGGAPCAIQPAPGEDPLLTLAICKPAIRRTAQPGDRILGITSHSLAHSDGYPLGAVIYAAIVREGLDARDYFTPDHTHRPDCIYQFHQHNGTASHNARSRLHAAPEHLLKDLGTYPFYRNGRILLSHDFRYFGPAAVRIPARLHLLTQAAEALGQGHRVYTDRDPESKEADALFRHLWKRPTAYTSTQVDSDAYEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV9</accession>
    <name>E8WXV9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581119.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2781"/>
    <dbReference type="EnsemblBacteria" id="ADW69804">
        <property type="protein sequence ID" value="ADW69804"/>
        <property type="gene ID" value="AciX9_2781"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2781"/>
    <dbReference type="eggNOG" id="ENOG5030NBU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166776_0_0_0"/>
    <dbReference type="OMA" id="WLINNYI"/>
    <dbReference type="OrthoDB" id="2099336at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="7066" checksum="0DA965F2F8E29339" modified="2011-04-05" version="1">MDVNQLIHIVIVLVVVGVLLGLINRFIPMASSIKSIINGIVVIFVVLWLLQLFGIIGAIGGMRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY7</accession>
    <name>E8WXY7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0454</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578854.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0454"/>
    <dbReference type="EnsemblBacteria" id="ADW67526">
        <property type="protein sequence ID" value="ADW67526"/>
        <property type="gene ID" value="AciX9_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0454"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_0"/>
    <dbReference type="OMA" id="RWQTMLQ"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="125"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="437" mass="46550" checksum="152C6374DE647D3F" modified="2011-04-05" version="1">MNAINETAPPLDPQNAHQTHVADSHGDRLDTQPETSPAPNQPNLKVDNSKGLGGSIWATLAVVAIIVIVVIAYGILHRKAEERKLEHTTVEASVPIVAVIHPSGNRLANELSLPGATQAYVDTPIYSRTNGYLKQWFFDIGAHVHRGQLMATIETPEVDQQLQVAQADLKSAQANLDLANTTQTRYQNLLKSNSVSKQETDEAIGNALAKNAAVEASQAAVRRLQQLQSFEKIYAPFDGIVTARNTDVGALIVAGQEGNGANARELFHLAAIDRIRVFVSVPEADTAAIVDGEHVSLTSDQFPGRSFDGVVTRNANAVDPSTRTLNVEVDVPNSAGTLLPGAYVFAHFKLSSHGQYLTLPSNTLIFRSQGLQVALVRDGRVHLVPVTIASDGGEIVEISSGVTATDQVITDPSDSIADGQQVTIAGQQGPQENGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY8</accession>
    <name>E8WXY8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0455</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578855.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0455"/>
    <dbReference type="EnsemblBacteria" id="ADW67527">
        <property type="protein sequence ID" value="ADW67527"/>
        <property type="gene ID" value="AciX9_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0455"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="WVQTPEY"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1062" mass="114261" checksum="141296F9B8A89001" modified="2011-04-05" version="1">MWIVKIALSRPYTFIVLAILILIAAPVIILNTPTDIFPAINIPVVSVAWQYTGLNPEELEGRLTTPYEKALTVLVDNIQHIESTTVNGQVVVKIYLQPGASLDTANAQVTSSAQFELRQLPPGTLPPQIINFSASSVPILQLGLSGAGLSEQILNDTGLNFVRPALVTVPGAVVPNVYGGKQRSIMVNLDPKKLQAQGLSPQDVLSAMATQNVTQPSGTAKIGMDEYDVKLNSAPVSIAGLNDLPLKQVNGTTIYVHDVANVSDGSIPQTNIVRQDGKRGVLITILKSGSASTLSVVSQIRGLLPQLKLTLPPALVITPISDQSVFVRASVVGVIREAIIAAILTGLMILLFLGSWRSTIIIAISIPLSILSSIIVLGLIGETINIMTLSGLALAVGILVDDATVTIENIERYLEEGNELETSIVEGAAQISVPALVSTLCICIVFTPMFFLSGVARYLFVPLAESVVFAMLASYILSRTLVPTMAMYLLKKHDHHAVPSRNPLARFQRGFERNFEKLRAGYQNLLNSLIVSRKVFVPAFLLLCLCAFLLIPFLGQNFFPATDTGSFILHLRAPSGTRIEETARLCDLVEQQIRKTIPSAQVDNILDNIGLPYSTLNFQHATSGLIGAGDADILVSLKEDHTATADFVRTLRSNLPKEFQGTTFYFLPSDIVTQILNFGLPSPIDVQIEGADIRGNRKVLDKILGEMRTVPGLVDLRVQQPDDYPTYDINVDRTKASQGGYNEKDVGGSVVNMLSGSTQLAPQFYWNTKNGVVYPLVALTPQYQIQSLNDLRNIPLSSANAKKPEILADVASIQRGTEMEVVNHYNIHRVVDIYGNVQDRDLGSVSKEIETIVDRNRKLLPKGSLIRVRGQVDTMRSSYFGLISGLGFAIVLVYLLIVVNFQSWLDPFIIITALPAALAGIVMFLFITGTTLSVPALMGAIMCMGVATANSILVVSFAKERFEHHGDALAAALESGATRFRPVMMTALAMIIGMIPMALGAGEGGEQNAPLGRAVIGGLSAATLATLVFVPSVFALLHGRRKSSAVATATQDANPHHAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY16</accession>
    <name>E8WY16_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0483</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578883.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0483"/>
    <dbReference type="EnsemblBacteria" id="ADW67555">
        <property type="protein sequence ID" value="ADW67555"/>
        <property type="gene ID" value="AciX9_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0483"/>
    <dbReference type="HOGENOM" id="CLU_1693024_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17041" checksum="5C6BE24972C12CA9" modified="2011-04-05" version="1">MMKHPEQFFGWAGPGLRLAAMHLLTKPFSPDRAHWREQHGGQLASNAPTVTNCEGMNRPDSTPDRAWISGLRDKYSRDGTTVLIDSTPMPTCDPKFAYFQTNLSALVDNGIQSMPLDSFTQDGRLHVNAAGSLLLSNMVANQISQRMSALTPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA8</accession>
    <name>E8WYA8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ordered locus">AciX9_1686</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580054.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1686"/>
    <dbReference type="EnsemblBacteria" id="ADW68735">
        <property type="protein sequence ID" value="ADW68735"/>
        <property type="gene ID" value="AciX9_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1686"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_0"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="28004" checksum="D9F21820851D5498" modified="2011-04-05" version="1">MRYWKMTLAYDGTAYHGWQVQPGLPTVQGRLAAALKLLTGETVLPQGSGRTDAGVHALGQVVSFGLEAPIPGENLLRALNRALPGAIRVLSVEAVEAEFHARRGAVRKTYEYRLFPRVGVRPERICSPMLAAYVWDCPWEIDLGRAEAAARVILGEHDFSSFAASDPDRTERLSGVERSNVRTVYESGWSELDGLMVYRVVGNGFLHHMVRNLVGCFVDAACGRTEVSEVAGILAAKDRTACGATAPASGLFLVGVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN5</accession>
    <name>E8WYN5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="FEBS J." volume="280" first="5815" last="5828">
            <title>Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase.</title>
            <authorList>
                <person name="Hajnal I."/>
                <person name="Lyskowski A."/>
                <person name="Hanefeld U."/>
                <person name="Gruber K."/>
                <person name="Schwab H."/>
                <person name="Steiner K."/>
            </authorList>
            <dbReference type="PubMed" id="23981508"/>
            <dbReference type="DOI" id="10.1111/FEBS.12501"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.46 ANGSTROMS) IN COMPLEX WITH MANGANESE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2015" name="ChemCatChem" volume="0" first="0" last="0">
            <title>Improving the Properties of Bacterial R-Selective Hydroxynitrile Lyases for Industrial Applications.</title>
            <authorList>
                <person name="Wiedner R."/>
                <person name="Kothbauer B."/>
                <person name="Pavkov-Keller T."/>
                <person name="Gruber-Khadjawi M."/>
                <person name="Grube K."/>
                <person name="Schwab H."/>
                <person name="Steiner K."/>
            </authorList>
            <dbReference type="DOI" id="10.1002/CCTC.201402742"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH MANGANESE</scope>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578961.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="PDB" id="4BIF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.46 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="4UXA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-131"/>
    </dbReference>
    <dbReference type="PDBsum" id="4BIF"/>
    <dbReference type="PDBsum" id="4UXA"/>
    <dbReference type="SMR" id="E8WYN5"/>
    <dbReference type="MINT" id="E8WYN5"/>
    <dbReference type="STRING" id="1198114.AciX9_0562"/>
    <dbReference type="EnsemblBacteria" id="ADW67633">
        <property type="protein sequence ID" value="ADW67633"/>
        <property type="gene ID" value="AciX9_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0562"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072993_1_4_0"/>
    <dbReference type="OMA" id="NVTFTPC"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="BRENDA" id="4.1.2.10">
        <property type="organism ID" value="13708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4BIF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4UXA"/>
        </source>
    </evidence>
    <sequence length="131" mass="14250" checksum="26D2C1101FFE06C5" modified="2011-04-05" version="1">MEIKRVGSQASGKGPADWFTGTVRIDPLFQAPDPALVAGASVTFEPGARTAWHTHPLGQTLIVTAGCGWAQREGGAVEEIHPGDVVWFSPGEKHWHGAAPTTAMTHLAIQERLDGKAVDWMEHVTDEQYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP1</accession>
    <name>E8WYP1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0568</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578967.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0568"/>
    <dbReference type="EnsemblBacteria" id="ADW67639">
        <property type="protein sequence ID" value="ADW67639"/>
        <property type="gene ID" value="AciX9_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0568"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_28_2_0"/>
    <dbReference type="OMA" id="ITCGVAD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230075" evidence="3">
        <location>
            <begin position="25"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="801"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="892" mass="96625" checksum="1AEAA2DC0F0C5CBD" modified="2011-04-05" version="1">MPCRVRLVWASLSLLSCILPRLSAQDLRYLRHQSWSTEEGLPQNSVHAIQQSADGFLWIATEAGLARFDGYSFKRFDHSNEPAFRSDDICCLANAPDGSLRIGTSDGLVLLQHGRFIRAKADEPFPAQNDQPLHGPAGSIWSSTNTAVTFTSGTNSLTWHAGSDLPGSRIESLFVDRHGIAWVGTNDGLVILHPGTKAATSIDALRGNAVLQTYEDHEGNYWIGTETSGLHILRPVAFRTEPSLADKALTTVIQATDGATWIGTRNDGLRRIVNSTTTQPAKLESLTSSVILSLAPGLDGSVWAGTPDGLNHVSQDGTVKKITSAEGLPDDYIQALLTAPDGSLWIGTRHGLVHLHDAVMDVLTAANGLGGDLVGTLMLTRQNELWIGTSGGLSHRSTEGKIKNFTSRDGLPQGIVTALAEDSAGRLWIATSAGALASLTQGVIHTVTTQSLDAPIHAIVPDQHGYLWLRTEHGIQRVLAADLAACAQGQTCPAQTNTYGLADGLPSEEMIAAGSPAMTMMANGELWSATRRGAAITDPATLQTSLIPPPVVIERLLVDEAPITLDGSSIEIPPGHVRYTLEFAALTFTTPSKVRYRYRLEGLDKGWTDAANKRSATYTNLPGKDYTFRVQAMNSDGLWSPTGAVLTFRVVRPFYKRWWFFTLLAALAVLAAIALYRRRLQRLQSRFDAVLQERSRIAREVHDTLAQDFVGVSIQLDIVTHLLTSNKTAAALEQVRQTRTLVTEGLAAARQSIWKLRANLAQDSLPTRLAEIVKRYTSDQLPIRLKIGGAFRDLDDSTENEILRIAQEALSNVQRHADASEASVDLRYESDMLVLTIQDNGTGFDPTRAARLEGHYGISGMKERTTLLGGSLELASTPGTGTTILLTIPMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR5</accession>
    <name>E8WYR5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1703</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580070.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1703"/>
    <dbReference type="EnsemblBacteria" id="ADW68751">
        <property type="protein sequence ID" value="ADW68751"/>
        <property type="gene ID" value="AciX9_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1703"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_0"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="36148" checksum="F5A01F594D41213A" modified="2011-04-05" version="1">MIDLRSDTVTRPTVAMRRAMSEAEVGDDVYGEDPTINRLEVRAAEVFGREAAIFVPTGTMGNQIAIRMHTQHGQEVICEARSHVLDWEMAMMASFAGCQARTVAAERGILTWGLLKAAIAPTIYYRAKTGLICLENSHNMAGGTVTPLGVLEEIWAGAKKAGLPVHLDGARVFNAAAALGVGVAELTKGFDTVMFCLSKGLGAPVGSMLVGSKDAIAEARSVRKALGGGMRQAGVLAAAGLIALEEMPKRLHEDHANARVLAEAVAGVEGVEIDLEAVQTNIVIFHLKDGGDAAAYVAALKERGVAASAIGPHAVRFVTHYDVSREDCVTAAGVAVEVLAGVGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX8</accession>
    <name>E8WYX8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2870</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2870"/>
    <dbReference type="EnsemblBacteria" id="ADW69893">
        <property type="protein sequence ID" value="ADW69893"/>
        <property type="gene ID" value="AciX9_2870"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2870"/>
    <dbReference type="eggNOG" id="COG3195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092522_2_1_0"/>
    <dbReference type="OMA" id="QEKFGHV"/>
    <dbReference type="OrthoDB" id="1777613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19550" checksum="94989B0D10F7F7C9" modified="2011-04-05" version="1">MLNGPAMNEILARWNEMDEVSAEAEVLPCNGSTAWAQGLAHGRPYADETAVYAASEKVWLGLTQDDWLAAFATHPRIGEKHAAASAKALAWSSSEQREAMAGEAYEAELLAEGNREYEAKFGRTFLICASGRSKREILEMLKARMSSTEEEEMNEAAEQQKQITRLRLQRWLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY2</accession>
    <name>E8WYY2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581212.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2874"/>
    <dbReference type="EnsemblBacteria" id="ADW69897">
        <property type="protein sequence ID" value="ADW69897"/>
        <property type="gene ID" value="AciX9_2874"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2874"/>
    <dbReference type="eggNOG" id="COG3257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056083_0_0_0"/>
    <dbReference type="OMA" id="DVRHDMH"/>
    <dbReference type="OrthoDB" id="1139895at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071522">
        <property type="term" value="F:ureidoglycine aminohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02212">
        <property type="entry name" value="cupin_UGlyAH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02211">
        <property type="entry name" value="cupin_UGlyAH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044697">
        <property type="entry name" value="UGlyAH_cupin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044704">
        <property type="entry name" value="UGlyAH_cupin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="26889" checksum="D8F9B8822352F56C" modified="2011-04-05" version="1">MHKLGETRSKLRQDHLLQTPDTFVRAALPGMQGGVGIVHIAPAAGAGFAQYTAELEAGGQLGNITAQRFFYVLTGAAEIVIDSVTYSLRAGSFAYLPQGQAHDVTASEAARLAVIEKTYVPLEGVESPKAFVGHESELTAMALGGDEDLRVRVMIPDAPWHDFAVNTMTYQPGAALSMVEIHVMEHGLLMLEGGGIYRLGDDWYPVTAGDFIWMAPYCPQWFGALGKVPAKYLIYKDWNRHPLAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ37</accession>
    <name>E8WZ37_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ordered locus">AciX9_2929</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581267.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2929"/>
    <dbReference type="EnsemblBacteria" id="ADW69952">
        <property type="protein sequence ID" value="ADW69952"/>
        <property type="gene ID" value="AciX9_2929"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2929"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_0"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="15161" checksum="B59AA6AA985BCF2F" modified="2011-04-05" version="1">MAKTQNQQKSGKAASGKGKKFKKRERKNVPYGLVFIQASFNNTIVTITDQTGNTISWKSSGSLGFRGSRKGTPFAAQQAAVGAANAARDHGLRSVDVRVSGPGSGRESAIRALATAGIDVRSIRDVTPMPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ93</accession>
    <name>E8WZ93_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnulose-1-phosphate aldolase/alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579023.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0624"/>
    <dbReference type="EnsemblBacteria" id="ADW67695">
        <property type="protein sequence ID" value="ADW67695"/>
        <property type="gene ID" value="AciX9_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0624"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024866_0_0_0"/>
    <dbReference type="OMA" id="KHGLVTW"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="734" mass="79852" checksum="342A24B9F780AF40" modified="2011-04-05" version="1">MAQNQLKFLEDRWDDKLAETLDAPELLRYRSNLLGSDLRITNFGGGNTSSKLDQKDPLDGQTKQILWVKGSGGDLGSIKRAGFATLYFDKVLALENAYRGVELEDEMVGMYPLCTFGNNPVAASIDTSLHAFLPFPHVDHLHPDWGIALAASANGKIKMEEFNKEFGHKLAWLPWQRPGFELGMMLRKIVQETPGCDGVVLGGHGLFTWGNTQRESYLNTVTIIDQIGQFIERHAAQPGYQLFSGAKVQARTDRSEIAQSIFPYLRGIVSRRQRWIGSFTDAASVLNFVNSAEAEALAHLGTSCPDHFIRTKIRPMFIKWNPAGDPSELKELIATALETYRAEYADYYKAHALLDSPALRDASPTVVLIPGVGMFSFGKNKTEARITGEFYINAVGVMQGAGALGEGKQCLDVPQAGPAASADKFKVHQNYVALPASEAFRIEYWALEEAKIRRQPPEKELSRRIALIVGGGSGIGREVALLAAERGAHVVVADRDTKGAESVAAEVKALIGKEAVTHVAIDITDRKAIRSALDATIAQFGGIDILINTAAIFPSSPDGIINDNLWAVTLEVNVTANFKLTDEAAIIFKEQGIDGSIVLTSSANAVVAKRGSEAYDVSKAALSHLVRELAVSMSPLVRVNGISPATVVKGSTMFPRDRVIASLSKYNLPFQETMTDDELRNVLAGFYAKRTLTHTPIDPRDCAQAIMFLAGPAARCTTGHLIPVDGGLVEAYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA9</accession>
    <name>E8WZA9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579039.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0640"/>
    <dbReference type="EnsemblBacteria" id="ADW67711">
        <property type="protein sequence ID" value="ADW67711"/>
        <property type="gene ID" value="AciX9_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0640"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="FENQILD"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="632" mass="67342" checksum="A3073A0108033DC0" modified="2011-04-05" version="1">MPTSTDATRRRFLAVCATAGLGHTVFPGALLALATTQLAPDAAPSLPKITAAMIDNAAAIAGITIDEPLKAAMLDGLNAQRDDVQEIRKLPLPNSVAPAMVFDPVPGGMVLDTTKQPLRMSSAPDLTALTAKLTQQNPDAAAETLAFATVRELAELLRTKRVTPTTLTRMYLARLKRLDSRLHFVITLTEERALKQAAQADQEIAAGHYRGPLHGIPWGGKDLLAVKGYPTTWGAAGFEHQTFDEDAEVVKRLDAAGAILIAKLSMGALAQGDLWFGGRTRNPWNPRQGSSGSSAGSASATSAGCVAFAIGTETLGSISSPSTRCGVTGLRPTYGFVPRTGAMALSWSMDKIGPICRSVEDCALVLSVITGPDGHDLAVKPAAFNWDAEFDWRKLRVGFIKSAFDAPTMPELKAPTAGGDTEMEAYKKRVTRMQANLVRTTYDAQFNQAALSQLTKMGVHMVPVEMPKLPFAAMVPVLEAEGAAAFDELTRSGRDKLLTGQQPFDWPNNFRVARFYSAVDYIQAMRARTLAIKAMAELFTQVDVIVTPSQGIQLTATNLTGYPAVIVPNGLRGTDAPPSPNDADGALDNTGGPGTPVSLTFLGNLYSDARLAAFARAYQQATGFHKQHPQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG2</accession>
    <name>E8WZG2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1802</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1802"/>
    <dbReference type="EnsemblBacteria" id="ADW68850">
        <property type="protein sequence ID" value="ADW68850"/>
        <property type="gene ID" value="AciX9_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1802"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_1_1_0"/>
    <dbReference type="OMA" id="VVPCCFD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="51"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="42511" checksum="62D000473E2A6EA7" modified="2011-04-05" version="1">MSTLLPILPPSDVLDENKDVLTPEAQAAEEEKNRMRRYFQKPEEQLTPVATQEPVCLYLETTNRCNLLCVTCPRTYEQLEPEADMPWEMFTSLIDQYPNIARVVLHGIGEPMLVKDIAERVKYLKDRNIYVLFNTNGTLLNDKNGRALIEAGLDELRVSLDAAESEVYQMVRGKDFFDKIVENVKNFTRLQREMNAPKPRVSLWLTGLRETVDQLPNFVRLSHEVGVTEVYLQRLVFFDEGSNGLARAESALFEHTTAAEEAMIAEAERVAAELGVMFSASGAVDPGESIRMQATDSPWSLCRRPWSLMYITANGRVLPCCIAPFSMKGYGSFTLGDATQHSLRDIWNGSEYQRFRDGLLSSAPPPACANCGLRWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK7</accession>
    <name>E8WZK7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ordered locus">AciX9_2958</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581295.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2958"/>
    <dbReference type="EnsemblBacteria" id="ADW69981">
        <property type="protein sequence ID" value="ADW69981"/>
        <property type="gene ID" value="AciX9_2958"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2958"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="8"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="697" mass="76537" checksum="75286C4BD8A2935F" modified="2011-04-05" version="1">MARTIPLNRCRNIGIMAHIDAGKTTTTERILFYTGITHRIGEVHEGTATMDWMEQEQERGITITSAATTCTWKNQRINIIDTPGHVDFTAEVERSLRVLDGAVACFDAVAGVQPQSETVWRQADKYKVPRICFINKMDKAGADAVYATSTIVDRLGARAIPINIQIGAEAKFLGVIDLVTMKAILWHDETMGAEYSVEEIPAALLETAQKARAVLIEAVADSDDEIMNLYLEGEEPTEAQLKTGIRKATIAMNIFPVLCGSSFKNKGVQTLLDAVVDYLPSPLDIPPMIGHNPDNMEQEIIRKADDSEPLSALGFKIMTDPFVGQLIFIRIYSGVLKTGDTTLNPRTGKTERIGRLLKMHANKREEITEIMAGDICAAVGLKNLITGDTICSEKNPVVLESIDFPKPVIEVAVEPKTKADQEKMGVALAKLAQEDPTFNVRTDVDSGQTIIAGMGELHLEIIVDRMMREYKVEANVGKPQVNYRETIRGNADAEGKYIRQTGGSGNYGHAKIRLSPNEPGKGYEFSNDTKGGTIPKEYIKPIDQGIQEAMQGGVLAGYEMVDIKVSLYDGSYHDVDSNEMAFKIAGSMAFKEAARKAKPVLLEPVMAVEVTVPEDYMGTIIGDLNSRRGRIEGMEMVGNTQAIRASVPLSTMFGYATHMRGATQGRANYSMQFKQYEEAPRSVSEEIIAKVQGKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM7</accession>
    <name>E8WZM7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2978</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581315.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2978"/>
    <dbReference type="EnsemblBacteria" id="ADW70001">
        <property type="protein sequence ID" value="ADW70001"/>
        <property type="gene ID" value="AciX9_2978"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2978"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_3_0"/>
    <dbReference type="OMA" id="CIAVTQR"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="158"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="33492" checksum="DCB6E341224454E0" modified="2011-04-05" version="1">MPQAPPNRTLGFAACALASSLWGCGFFFGKIALAEMNVGAMVFYRFLFGTVVLIPLLFTHKPRFTRRDWLILLAASFLGVPVQFLLQFYGLSLTTVSHASLMVGTMPVILAVGAAIHAHERMDRTGWLALSPSTLGAALIALSAHPHGPNQATLTGDLIVVVSLLIALFWILMNKHLMDGVSPEEKHSPIAVTSYGLLLGTVMLFAIVPPIWGLPPIHHISVKAWLALIASGVLCTATTTLLWNWGLTQVPASQAGVLLNMEPLLGSILGVVVLKETLGPTAWVGGLMILAAAVTLTTHSKTHIRKELEPVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ4</accession>
    <name>E8WZQ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581342.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3005"/>
    <dbReference type="EnsemblBacteria" id="ADW70028">
        <property type="protein sequence ID" value="ADW70028"/>
        <property type="gene ID" value="AciX9_3005"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3005"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_0"/>
    <dbReference type="OMA" id="RFAENCE"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="31316" checksum="84E10CE8204F66CD" modified="2011-04-05" version="1">MRIFVTGATGFIGTALIPELIQAGHTVLGLTRSEEGAEKLRAAGAEVLNGNLEDLDSLRKGAADSEGVIHLAFSHDFSQFEKNAADERAAITALGEVLAGSDKPFVVTSGTAIAANVDGKPSTETSAISPWNPRSGLEATVKTFTERGVKTSIVRLAQIHDTRKQGLVPYFLAVTRAKGVSGYVGDGSNRFPAAHVSDTARLYRLAFEKAEAGAIYHAVDEEGVTTKAIAEAHGRGLGIPVVSIPPTEVEAHFGWLAMFANADMPSSSELTQKKLNWKPTGPGLIADLDAMDYTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX8</accession>
    <name>E8WZX8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0719"/>
    <dbReference type="EnsemblBacteria" id="ADW67789">
        <property type="protein sequence ID" value="ADW67789"/>
        <property type="gene ID" value="AciX9_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0719"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_0"/>
    <dbReference type="OMA" id="GKHDPFF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="32274" checksum="CCDBD1A4900C3366" modified="2011-04-05" version="1">MTVAAIHRVEADGVSVFYREAGPVDGPVVLLLHGFPTSSFQYRELMPLLADKYRVIAPDLPGFGFTEVPAERGYKYTFENLAKTIDAFTEALKLTRYALYVFDYGAPTGFRLAMAHPERVTAIVSQNGNAYEAGLGDAWAPIQTYWREPTAEHREVVHQALSADGIKEQYTYGVPHPERIKPEGYTLDAAMILRPGNMEIQLDLFLDYANNVKRYPAFQEYFRKAKPPLLAIWGEHDPFFIPPGAEGFKKDNPNATVQFLDTGHFALETHVVEVAGAMREFLGRALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X010</accession>
    <name>E8X010_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1860</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580225.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1860"/>
    <dbReference type="EnsemblBacteria" id="ADW68906">
        <property type="protein sequence ID" value="ADW68906"/>
        <property type="gene ID" value="AciX9_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1860"/>
    <dbReference type="eggNOG" id="ENOG5033R1F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846659_0_0_0"/>
    <dbReference type="OrthoDB" id="1309990at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="328" mass="36579" checksum="905BF571D2533529" modified="2011-04-05" version="1">MMETTGQPAALRKVYMVLSPHSLSYARLAIESVLRNSVDAMHLHLITDSAEDKQTLSDAVTELAPDVRHEWSVAAEDELADAEASVFAGLPHLRGFRHGHPCWRKITDPVLMGKPGEELILLDPDLYFPNRFRFEPTPETGLLLMWQRPNCLLPPEVVRAAIAARVPLARHVDIGVSHWRGGADLEWVDWLIGKLGGASLPRMMHVEAIVWSAIAMRQGGGYLDPKLWVCWHRTQARRLRRKLGVSGKSILAAEPWATMKCFHAGGEAKWWLPETLAAGTARSDEALTLAGEVVPFVELTAARYEQEQRTKGLLRGLGYYRVFNAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X071</accession>
    <name>E8X071_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3032</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70052">
        <property type="protein sequence ID" value="ADW70052"/>
        <property type="gene ID" value="AciX9_3032"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3032"/>
    <dbReference type="HOGENOM" id="CLU_3200393_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="45" mass="5418" checksum="D2F4BFA3510EB1B8" modified="2011-04-05" version="1">MTDMFFPSMLLFAIVCIPLAFLPQYDLCTERCRAFFRHLLHRKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A8</accession>
    <name>E8X0A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase</fullName>
            <ecNumber evidence="6">5.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3069</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581403.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3069"/>
    <dbReference type="EnsemblBacteria" id="ADW70089">
        <property type="protein sequence ID" value="ADW70089"/>
        <property type="gene ID" value="AciX9_3069"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3069"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_0"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="25295" checksum="5AD45E7C6B9ACD7B" modified="2011-04-05" version="1">MLIPSIDLMGGRIVQLVQGEKLKLAFDDFEYWIDRFSKYPLVQLIDLDAAMRQGENTALIEMICKRLPCQVGGGLKTAEDGQRLLDAGAKRVIYGSSLFGAATEAEGKRRHKLIRLEFAEGLKKTLGEEAICFSVDTKAGKVAVKGWKDSVDLTPEEAVTWLEDSCAAFLYTHVDTEGTMTGFPIDVAAILRACTAKQLIVAGGIKERAEVDALDAMGVDAVAGMAVYSGAMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I9</accession>
    <name>E8X0I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl xylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0784</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579179.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0784"/>
    <dbReference type="ESTHER" id="acism-e8x0i9">
        <property type="family name" value="Acetyl-esterase_deacetylase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67853">
        <property type="protein sequence ID" value="ADW67853"/>
        <property type="gene ID" value="AciX9_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0784"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018290_0_0_0"/>
    <dbReference type="OMA" id="HIPYEGR"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234045" evidence="2">
        <location>
            <begin position="18"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="AXE1" evidence="3">
        <location>
            <begin position="99"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="673" mass="72007" checksum="DD975EBA598E871F" modified="2011-04-05" version="1">MRAALLLVLALAPLASAAQTPATRVDPNSPDNAARKALIESLDHLAATQTAARRAEIAKIHTQAQARARQAHVRETMLRLIGPLPTRTPLNAQVLGTTNLPGVRIEKLLYDSQPNFHVTALLYLPDVPQGTKLPAIVMAPGHSPAGKAGDSPFALAFARAGIAVLSYDPLGQGERLQYPDPASAADHSVPGKTLAKQPTGEHGEASLQPILLGETLAKYMLWDGMTAVDYLQTRPEIDPTRIGAFGCSGGGAMTALLGALDPRIAATGTACYITSFDTLLPIQGPQDGEQSTPGWLSNGLDFPDWIELASPRPYAIISTTEDMFPFAGAQSTEAESRRFYSLFTADKSLAFITGPGHHGNLKPILPQIIQFFATNLHAVPPAVQGTDIAPREALQVTPTGQVSTSYPNTATVFTLNLAGPGHKMRQELRPNTGRYLEQNVRDVLVIPPPTPGLPFKPSLLSESSATAFLSPDTFTPSPPHKPGAKFAAVLLLTNEPITQPAEGQDFTAIQNRFMDLVEEEGKAALLLSSRPSPAGSEELKTPLLGPYYLLGLRAELVGKTLLGLRVEDTLQAIDELASLPNIDPTQITAEASNHEALILLHAAVLDPRLKHITLHNLPPTYAQLLATPIPKDAPQDILPGVLLHYDIPDLIRALGPRVTIIPEEKKDNQTPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J9</accession>
    <name>E8X0J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0795</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0795"/>
    <dbReference type="EnsemblBacteria" id="ADW67863">
        <property type="protein sequence ID" value="ADW67863"/>
        <property type="gene ID" value="AciX9_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0795"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114584_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="6">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26598" checksum="7C2E2DED2ED80353" modified="2011-04-05" version="1">MGVVSVSLLRSSVFWTVDDLQQAAGRPAFAVLTQNAGPLQLKDGVASRRGFEEDLSALHEFITHLPAEFSTPCMMFTSTLPREGSSTIVAAFAAALARAGSKVLVIDGNLHHPSMHEAFGINARVGLTHVLEQHATLQQAVQTVADLPSLHILSAGPVPPDPFALLLSSDLRGLLQSATDRYDYVLIDSPPAGRFPDAFYLASLSNVVFVIAKYGIVQRQPTARLLRKISTPDLLTSGFIVNGALGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V1</accession>
    <name>E8X0V1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactate/malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3119</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581449.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3119"/>
    <dbReference type="EnsemblBacteria" id="ADW70135">
        <property type="protein sequence ID" value="ADW70135"/>
        <property type="gene ID" value="AciX9_3119"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3119"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045811_0_0_0"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="38572" checksum="CEFA40BA237D1E6E" modified="2011-04-05" version="1">MALSIAIVGAGGAVGSALLMHLLKSSTLQAGDEVVLLGRGTPESSGRLFAIRMDLLDAFDESAIRISVCESIGDLKADVVIIAAGYTISPSRRTRRDLAASNQPLFQSLAAKLSRTVPNALFLIVSNPVELAVGIFAAHMEPQRVIGIGAQQDSLRFARAIASQIGVHRSKVRASVLGEHGQAMVPLWSSVHLTLDEPETASRLAALIERFENSDTRSEVNRTRDTLESLLADHQLAAAYEVMEHVSPSTRIMLEPFITHSQIHSTPNATANATLEILGAALMADGRRVHGQVQLHGQFQGIKGVCGVPLEVRLTGWQVSSQLRLTASEIADLHAAAEAIEVAIQESRKTECELLTHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X135</accession>
    <name>E8X135_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0833</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579226.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0833"/>
    <dbReference type="EnsemblBacteria" id="ADW67901">
        <property type="protein sequence ID" value="ADW67901"/>
        <property type="gene ID" value="AciX9_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0833"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_0"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="184"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="401" mass="41896" checksum="D9B43765D0410C6A" modified="2011-04-05" version="1">MTNVLEFEAALAVVREHAAGLVAVAGVETVGLLAARGRVLAEEIRADRDQPPFDRATRDGFAVRAGEFGLGVPVRVVGMVKAGEQWLGKVMEAGEAIEIMTGAPVPEGADAVVMVEHVVRDGETVKAEAGRTWRVGESIVPRGREAKAGDVVVAAGTVMGAAEIAMGSACGCVSVVVKRRVRVAIAATGDELVELEETPGEIQIRNSNSYGLAAMVEAAGGEAVRLPITADERGAVASTLRRALECDLIVLSGGVSMGEYDLVEEMLTVAGAEFFFTGVKMQPGKPVVFGRMGEKLFFGLPGNPISTQVTFHCFVEPVLRALGGAGFTGPRFGLARMSGAGERKAGLTRLLPGRLDGTDVSVVGWQGSGDLAANARANCYVELLPGDGEVEAGEIVRVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X139</accession>
    <name>E8X139_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0837"/>
    <dbReference type="EnsemblBacteria" id="ADW67905">
        <property type="protein sequence ID" value="ADW67905"/>
        <property type="gene ID" value="AciX9_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0837"/>
    <dbReference type="eggNOG" id="ENOG502ZB4S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073797_3_0_0"/>
    <dbReference type="OMA" id="FRIHYGI"/>
    <dbReference type="OrthoDB" id="1968186at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234256" evidence="1">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="271" mass="29454" checksum="CADC48D8E3A4702E" modified="2011-04-05" version="1">MLKARTLILFPALVALAACGAANARAQILGLGKPAAPVVIPTLQAPEPGYVFPAKQTLTFSVDWRVFTAGTAVFHLEQNGTQEKVTATADTVGNTNMLFPVVDKFEAGLDTKTGCSTGFSKQLQEGRRKVTSDLTFNYGQGKQYETSKNLVKGTSANRQASIPACVQDSLSAIFYVASRPLVVGQTVGFPLADSMRTVTVNMKVEGKEEIKTPAGTFQTIRVQPTAEEGVVKNRGNIWIWYTDDARHMPVQIRARLFWGTITFHLQSVEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X163</accession>
    <name>E8X163_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0861</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0861"/>
    <dbReference type="EnsemblBacteria" id="ADW67929">
        <property type="protein sequence ID" value="ADW67929"/>
        <property type="gene ID" value="AciX9_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0861"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017775_0_0_0"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="595"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="830" mass="93223" checksum="EE50D0CC5B0D67C5" modified="2011-04-05" version="1">MGRGGPNARRGMYIREIPEAHDSDRNSTATREGLYLQTTNLSADTFTSSLSSSHDGGLDLICFSHLRWHFVTQRPQHLLTRCARERRVFFWEEPYWDADDNGDGTPTLEVMQEGPQLWVLRPHLPRAGDANAMLRGLLKEFMRAQHVARFVRWYYTPMMLSFTDDLRAEATVYDCMDELSGFLGAPPELAAREQELFGVADVVFTGGMSLYEAKRKQHGNVHAFPSSIDVGHFASGSGAEEPGDQGGIGRPRAGFFGVLDERFDIGLMGEVARLRPEVQFVLLGPVVKIDPGTLPRGENIHYLGGKSYGELPGYLAGWDVAMLPFALNESTRFISPTKTPEYLAAGKPVVSMPIHDVVTGYGREGLVAIAGTAEEFAAAIDKALEPQTAEWLEAVTAKLAGGSWDKTWASMWKQIELVRVRSAEVKGVGVASFRLAPVSVRMKAGRGEQYDYLVVGAGFAGGVLAERLANGLGKRVLIVDKRDHVGGNTFDYLDEAGILVHKYGPHIFHTNSTEVVKYLSKFTQWREYEHRVLAEVDGKLLPIPINLDTINRMYGLELDAAGMQRFLAERTETATSIRTSEDICVSRIGRELYEKFFRNYTRKQWGLDPSELDASVAGRIPVRFDRDDRYFTDTFQAMPSLGYTKMFEKMLDSPRITVRTSTNYADVVKEHPGIKTIFTGPVDEFFDYRFGPLPYRSLEFRHETFDEEVRQPVGVVNYPNEHAYTRVTEFKYLTGQTAAKTSVVFEYPQAEGDPYYPIPRPENAALYARYKELADAEKNVHFVGRLATYKYYNMDQVVAQALVTFRKIREAEFPAVEIGMREGFEASATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I2</accession>
    <name>E8X1I2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3206</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581529.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3206"/>
    <dbReference type="EnsemblBacteria" id="ADW70217">
        <property type="protein sequence ID" value="ADW70217"/>
        <property type="gene ID" value="AciX9_3206"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3206"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_0"/>
    <dbReference type="OMA" id="DIHMPDF"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="30247" checksum="967CBA40E446A34B" modified="2011-04-05" version="1">MPLKVVIVDDELLARQELQYLVENAGDVQVLALGSNGIEAVDLIHKHKPDLVFLDVQMPGLDGFGVLKKLLEKKARLPQVVFATAYDQYAVRAFEVNAVDYLLKPFDKSRIERTIAKARERVALVEASIAPDSAEAKLDALLRLVEEASQTPKVQRGKIVLRAQNRLMLVDQKEICFVSIEDGAISVVTPAMEGQSNCRTLEELMEQLDPEAFWRAHRSYVVNIQHIREVVPWFKSSYQLRMDDPKKTEIPVSRNQTKRLRELFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S4</accession>
    <name>E8X1S4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ordered locus">AciX9_0926</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579317.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0926"/>
    <dbReference type="EnsemblBacteria" id="ADW67993">
        <property type="protein sequence ID" value="ADW67993"/>
        <property type="gene ID" value="AciX9_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0926"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_0"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25052" checksum="311F857C341945EA" modified="2011-04-05" version="1">MAQKISKNLAKARAMVEPRPYTLVDAVPLLQKAKYAKFDETVDITLRLGVDPRHADQMVRGTVVLPHGLGKSKTVAVIASGDNIKAAEAAGAEFFGGEELVERIQKEGWTAFDALIATPDMMRSVGRLGKVLGPKGLMPNPKTGTVTTDVASAIREIKAGKVEFRTDKTALVHVPVGKLSFEPQKLIDNAMTVITSVLKAKPSAAKGKYIKGMTISSSMGPGVQLDSSVSDLAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S8</accession>
    <name>E8X1S8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="11" type="ordered locus">AciX9_0930</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579321.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0930"/>
    <dbReference type="EnsemblBacteria" id="ADW67997">
        <property type="protein sequence ID" value="ADW67997"/>
        <property type="gene ID" value="AciX9_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0930"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_0"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="236"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1359"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1396" mass="156267" checksum="1F4D4541577DA85A" modified="2011-04-05" version="1">MFRSSPFELTGPIADFDAIKIQLASPEKIRSWSHGEVTKPETINYRTFKPERDGLFCARIFGPITDWECLCGKYKRMKHRGVICDKCGVEVTLSKVRRERLGHIELASPCSHVWFFKGLPSRIGHLLDISLRELEAVLYFESYVVVDPGDAPVKEREVIKDEARYRELDTQYRVSGFKAMMGAEAIKELLKRVEIIELSIELRERMKTETSLQKKLKYSKRLKIVEAFRKSDNLPQWMILDVIPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKKLMDLHAPEVIVRNEKRMLQEAVDALFDNGRRGRVLRGANNRPLKSLSDTLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYHRLEQTGHCTTIKQAKEMVEMQEPIVWDILEEVIKDHPVLLNRAPTLHRLGIQAFEPVLVEGKAIKIHPLVCTAFNADFDGDQMAVHIPLSPEAQIEASVLMLASHNILSPASGQPITVPTQDLVLGLYYLTKAKVNAKGEGRVFANIEEVFMALEAKQVETLTPIRLRYTGMVLDMTTAYDDQDLTHTEPVEYKNQFISTTVGRAILNDALPEDMPFVNGLLKKKGIGQLINYCYLNLGLEVTVKTLDRVKDLGFTYATRSGLSVGLDDMVIPDSKYTVVAEAEKQVINVQQQYLDGAITNGERNNKVIQLWSTVTERVADEMFNNMKQADKDGAMNPIYIMADSGARGSKQQIRQLSGMRGLMAKPSGEIIETPITANFREGLTVLQYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIISHNDCGTVEGIYVTPIIEAGETIEPLRDRIIGRVSLEKLKDFEGKVIVDINEEIDEDKASAVQAAGIEKVKIRSVLTCESKRGCCILCYGRNLGSGKMVEMGEAVGVIAAQSIGEPGTQLTMRTFHIGGTASRVSDASHLEAKNAGSVRFINLVTVRSKEGHLVAFNRNGSIAIIDEKGREKERYAIVYGAKLRVEDGVQVKQGDYLGEWDPYTFSLLTEIAGTVQFKDLQEGVTLNEEVDEVTGLSRLVVADSPDEKRQPTIIIKSAQGNKRYLMPSRAHLMIQDGDEVHPGDILAKIPRETTRTKDITGGLPRVVELFEARKPRDPAIISKIDGVVRFGDVSKGQRKVYVTADNGQEEEYSVPRGVYVNVQEGERLRAGDPLIDGPRSPHDVLEVLGERAVQMYLVNEIQEVYRLQGVTISDKHIETIVRQMLRWVKIEEVGDTNFLVDQQTDRFRFNEENQRVLMTGGRPAIGRSLLLGITKASLSTDSFISAASFQETTRVLTEASINGSIDTLRGLKENVIVGRLIPAGTGMEYYRNVQLSPELEEAAAQVQQEVTAAIEAEERELEQMRMEGEQEEMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y6</accession>
    <name>E8X1Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YceI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2103</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69147">
        <property type="protein sequence ID" value="ADW69147"/>
        <property type="gene ID" value="AciX9_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2103"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_0"/>
    <dbReference type="OMA" id="RFSYSHF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230574" evidence="1">
        <location>
            <begin position="50"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="53"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="23389" checksum="61CCC72936645092" modified="2011-04-05" version="1">MPTNRSQPGNSTLRWNGTSSEILKGTNMKLLNTATLLAAALTLSTAAHAQATAWTIDSAHSGVNFEIRHLGVSNVRGSFHKVTGTINLDEKNITHSSVEATIDTTTVNTDEPKRDDHLKSAEFFNVAQFPTMTFKSTSFTNVGGKLKMTGNLTLDGVTKPVTLDVDGPAAPQKGMGGKTVSGFSASGVIHRAEFNFGQKYTAPMLGDDVKFTIDIEMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z9</accession>
    <name>E8X1Z9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2116</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580476.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2116"/>
    <dbReference type="EnsemblBacteria" id="ADW69160">
        <property type="protein sequence ID" value="ADW69160"/>
        <property type="gene ID" value="AciX9_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2116"/>
    <dbReference type="eggNOG" id="COG1480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989113_0_0_0"/>
    <dbReference type="OMA" id="DFFHVAR"/>
    <dbReference type="OrthoDB" id="1101758at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34090" checksum="DD340468622E0CD0" modified="2011-04-05" version="1">MAATAHGAQPVRGTQSFVRTLSLCWTNPGLTGLEVLWRWVYGMPAVWVVVVQLRRILLAATDGTLDPARLGLDRTLLNDPVGALTADPMGAAGKFAGAIGLVLPQILHLGAWLAPLLLATWVIVSSFGRTAVLRRVDPTLHARPITLMILQAIRITALAASFVIWFKALTWSSHTAITGPIAAGSEPNLVLYCALVIVLTIALFILWSLVSWWFGVAPLLAMLNDTGPLASLRAAGNLGALKSNLIEINLVMGIVKIALIVLAMVFSATPLPFQSVTTPEFLAWWWAAVTVVYLLGSDFFHVARLVSYLDLWRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X248</accession>
    <name>E8X248_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_3280</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3280"/>
    <dbReference type="EnsemblBacteria" id="ADW70291">
        <property type="protein sequence ID" value="ADW70291"/>
        <property type="gene ID" value="AciX9_3280"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3280"/>
    <dbReference type="eggNOG" id="COG4774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_0_0"/>
    <dbReference type="OMA" id="FSWRPDD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230174" evidence="7">
        <location>
            <begin position="20"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="325"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="795" mass="86364" checksum="D94888B1A8C09785" modified="2011-04-05" version="1">MLLTASVLLFCSATIPALAATTPAAPATSCSIENNSPVTAVTIHVTDPSGAMLDRAAIELRCGSTVLNGITGKDGSVTLSLHPGSYILTAQAPGFADVTQPVQAPVLAPIDLQMPLGSATDTINVSGDSGFVPYASNAGSKTNALLIEVPQSISIISQQEMEARNVITMNEALRYTPGIQADEYGVEPRFDWLKIRGFDAQTFGVYRDGMRFNSLAGKLDPFELESVEVLKGPSSVLYGEVPPGGLINQVSKRPSSERSTVIEGQFGQYDRRQGAVDTTGPIDRAGVFRYRLLGLIRNSNTQTNFTPDDRRLIAPSLSFHPSDRTNLTLLADYQHDKTAWSQFLPSQGTLNSNPNGIIPVSTFLGEPGFDGVHRNQASVGYTGDHLFSDGWNVHSNYRYQYINFQGRTIYGNGFDTTIPNNTTLVTRTAYALPNINRINTVDTRALRRFVTGNWQQTVIFGYDYQHIDIKQQAGSSSVADLNIFHPVYGVTTIPALFFYQNNDSLLQQHGLYAQDQIKFKQHFVFTLGGRQDFARNDISNFLAANSNTSHSDVRFTGRAGVTWLTGSGIAPYFAYSTSFLPNAGSFVVNAVTNLPTDPAKASDARQLEGGVKIQPRTTNSFITASVFQINETNVLVADAAFNNHQSGEVRSRGVEIEGVASLSHGLNLHAGYTLTATNTVQDITQANIGKWLPQTPRNQVSGLIDYTQRGGRFAGLGGNFGVRFVGTNAADSINSFFIPNYALTDAGLRFGYRHTLFSINATNLADKRYVATCSGASYCYYGYARNVIGTAKYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X277</accession>
    <name>E8X277_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3309</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581632.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3309"/>
    <dbReference type="EnsemblBacteria" id="ADW70320">
        <property type="protein sequence ID" value="ADW70320"/>
        <property type="gene ID" value="AciX9_3309"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3309"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_0"/>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="35467" checksum="3065BB556079629A" modified="2011-04-05" version="1">MKINMPPRKVAAYAAVYLFWGGSFLAIRNVVHIVPPFFAAAMRYAISGPILLFLSFYVRKEARPTRRQIMNCLMTGVITFSLGYSVVFWAETRLTSWLVAVLTATTFLWTYLGECLLLRTERLSKKMLLPLLLGLAGMPLLCGASFHQGKMWSLLAILAVLLGAVTSAGGVLLIKRLEMPPSFLQTAGFQLIFAGLTLFMFSGALGELKRLPPVSQFFSYRLLTGMAYLVFCGSIIAFTSFQWLLKHDKATLASTTTYAHPIVAMVVGIVFAHEQRSFTQLLGAFGLLGSVAAVWYVQANFSPPEPVDYDARFEADLQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T5</accession>
    <name>E8X2T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3374</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3374"/>
    <dbReference type="EnsemblBacteria" id="ADW70382">
        <property type="protein sequence ID" value="ADW70382"/>
        <property type="gene ID" value="AciX9_3374"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3374"/>
    <dbReference type="HOGENOM" id="CLU_157872_0_0_0"/>
    <dbReference type="OMA" id="FRCKDCH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14404" checksum="1A8D17CAFCD232D1" modified="2011-04-05" version="1">MAAEREKIYECEVKRRRVRAGGGYEAFWKVKTLVEALADLDTEFRCKDCGGAVKLLGRNGKAGTVPFVEHKDPSDAAFCSSGLLFRKSTDGREARLSPRPVMLRTGLPGVRPDTIALPAFVPAPIVVEGIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V2</accession>
    <name>E8X2V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1023</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68086">
        <property type="protein sequence ID" value="ADW68086"/>
        <property type="gene ID" value="AciX9_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1023"/>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979286_0_0_0"/>
    <dbReference type="OMA" id="QRTMGDA"/>
    <dbReference type="OrthoDB" id="1236349at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="280" mass="30061" checksum="BC92D7280B6E6EE5" modified="2011-04-05" version="1">MSGQYETNGAERPLPMAVKASLGAAILLALGALIWCFGLSNHLSVAEKQLAAAEQRNSELAQKQDALSARLRATTETLGNSVGMTQKQIDLKTASLLAAQQAAVRAQTAQTAKLEEQQAAASKQIGAVASDVSNVKTDVGGAKASIAETQNDLNTTKAQLQRTMGDAGVMSGLIARTHDDLELLKHKGDRAYFEFTLRKGDKPTLLSSIKLQAKKVDDKHSRYTMIVSADDRNIEKKDRSLDEPVQFYSGKDPALYEIVVNNISKNTISGYLSTPKGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X329</accession>
    <name>E8X329_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2209</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580569.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2209"/>
    <dbReference type="EnsemblBacteria" id="ADW69253">
        <property type="protein sequence ID" value="ADW69253"/>
        <property type="gene ID" value="AciX9_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2209"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303450_0_0_0"/>
    <dbReference type="OMA" id="QPALFLH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="618"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="691"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="756"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="987" mass="110130" checksum="33CD3163C8726AB2" modified="2011-04-05" version="1">MKNAAQTRILAIILAVVTLGACVLAGVNFSAESNYNVPTDGIWWLETNGGLCAQQVPVDSPGQRAGVRAGDVLITVDERPTLALAPFIHQLFRDGTYGRATYLIARPAKRCQLQPSSTKFDIQVILEPTDRSINYGLRIIGVVYLLIGLYVLFRRWTAPKSTHFYVFCLVSFVLYAFKFTTELDTFDWIIYWSNVVATFLQPALFLHFAFTFSDTAPDPAHRTRRGILSTFLYLPGLYLLGLQIVSIVHWSATEVLKHRLDKIALAYMALYYVVAAALFFIRARSSENPLERQQLKWLTRGTLVAVIPFTLLYVLPFLLDYAVPAPVANFVRLALIILPLTFSWAIVRYRLMDVDLIFKRGVTYTLATAALVGLYFGVVAVSAEMVHTRLPSLRVWGLLAAIVATGLIFDPLKRTIQARVDRVFDQKRFDYRETLIDFGRSLNSQTDLRALVDSVVERLPQTLLVTRVAVFLASEPDADNRPAPKPTFELAASHGLTNLQAQDLRALDIRFLDFDALDANSHLFLENPQQVLRLPEAQRETARRLDLNYYLPCRVANRVGGGTRTVAIIGLGRTGDGDFLSSEDMEVLESLAGYIGIAIQNAQLYKSLESKINEFERLKDFNQNIVESINIGIFAVDLEDKIESWNAQMEVLFARPRSEAIRRHLSEILPSDFLARFNAIRGDGTAHGTHTLYKFRLALPTGETRTANIAIAPLLTRNLDVVGRIILVDDITDRIQLETQLTQSEKLSSIGLLAAGVAHEVNTPLAVISSYTQMLSKQLRDDVRIAPVLEKITQQTFRASEIVNGLLNFSRTSGAEFVSIDLNQLLRDSAILLEHQFKTARIRLDQELAPDLARIQGNQGKLQQVILNLMLNAKDAMQGTSTGLITIATRNEHDQVILEIRDTGSGIEREHLHRIFDPFFTTKTNPQPGQHKGTGLGLAVSYGILQEHGGKITVDSEPGQGTTFRLEIPATESPNKTPVYATSQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X360</accession>
    <name>E8X360_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2243</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580600.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69284">
        <property type="protein sequence ID" value="ADW69284"/>
        <property type="gene ID" value="AciX9_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2243"/>
    <dbReference type="HOGENOM" id="CLU_2916064_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6372" checksum="B839ACDA13369754" modified="2011-04-05" version="1">MLTIIHIVISVINAILRDVANVLLAGGAIVLTAITVLIAAGIALGISGFGAFRFLKKRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B8</accession>
    <name>E8X3B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581731.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3413"/>
    <dbReference type="EnsemblBacteria" id="ADW70419">
        <property type="protein sequence ID" value="ADW70419"/>
        <property type="gene ID" value="AciX9_3413"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3413"/>
    <dbReference type="eggNOG" id="COG4374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135601_0_0_0"/>
    <dbReference type="OMA" id="CNEEDAI"/>
    <dbReference type="OrthoDB" id="1647539at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="14935" checksum="76D04EE68A585308" modified="2011-04-05" version="1">MSDVPKPRVIEVVVDASAVLAILLREVDDKTFNNLEGLLGRSIISAVNLAEVRTRLSDLGKLQLTSMNEVLDLILRVEPFTEAQAILAADLRPSTKSLGLSLGDRACLALALGKGLDVYTADQAWSKLQLDCAVHLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G9</accession>
    <name>E8X3G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1097</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1097"/>
    <dbReference type="EnsemblBacteria" id="ADW68160">
        <property type="protein sequence ID" value="ADW68160"/>
        <property type="gene ID" value="AciX9_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1097"/>
    <dbReference type="eggNOG" id="ENOG502ZD31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077142_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024524">
        <property type="entry name" value="DUF3800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12686">
        <property type="entry name" value="DUF3800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="26230" checksum="C34D6E5FB806164A" modified="2011-04-05" version="1">MHLLYADESGSISDPSQRFFVLAGVAVFERSTHWVEVELNQIAARFNPAEPHEVELHGSPMRTGSHGWSDHGQALRKQAIVDALSLGVAKHHPRDLRLFAAVLEKNNFAGQDIAQIAFEQLSSRFDQYLGRLYREKGDKQRGLILFDKSSTERRIQTLARDFKHTGHSFGITRNYAEVPVFLDSRASRLIQLADLVAYAIFRHHEHGDSTYYNACSHCFDAEGGVVHGLYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H2</accession>
    <name>E8X3H2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1100</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1100"/>
    <dbReference type="EnsemblBacteria" id="ADW68163">
        <property type="protein sequence ID" value="ADW68163"/>
        <property type="gene ID" value="AciX9_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1100"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_0"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="301" mass="34226" checksum="7C6DEC5BC777668F" modified="2011-04-05" version="1">MHPNTPSRLHELSSEEALVYSQLDPSRIPRHVAIIMDGNGRWAGKRTLKRFKGHQQGAESVQFVVETASRIDLPWLTLYAFSLENNLRRPKSEVSFLMTLLKSYLVGNVKRMNDNNVRMAYIGRTLGLPQEIQDTMQWASEETSKNTGTTLTLALNYGSRSEIVDATRSLVEKLIDEAHHRGISLEDLLQVDSLDSRIDEAQLSANLYTAHMPDPDLVIRTSGEQRISNFLLWQIAYSEIFVTDRLWPDFRGVHLLEAIENFQHRERRYGGLGEGTDEHLEGKDDALETPESIAAELLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H3</accession>
    <name>E8X3H3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579487.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1101"/>
    <dbReference type="EnsemblBacteria" id="ADW68164">
        <property type="protein sequence ID" value="ADW68164"/>
        <property type="gene ID" value="AciX9_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1101"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129778_0_0_0"/>
    <dbReference type="OMA" id="MMAPVEQ"/>
    <dbReference type="OrthoDB" id="1432360at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19581" checksum="CC6BE5CA46D0F53A" modified="2011-04-05" version="1">MATMMAPVEQREVLRCDHCSLVQFRTATAACRRCKKSLEVEKPVPAPAPLALVPALKAADQGIQVATAVRDLRHVRNLSQRQLAARMNVPRTYISKIENGKAMPTLSSLDRLARALEVDISALLRDAPTRHSNETAMLVTDPFLAEIAAYTSQLDSLQRSIFLNHVRELAAGRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M6</accession>
    <name>E8X3M6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ordered locus">AciX9_1154</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579540.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1154"/>
    <dbReference type="EnsemblBacteria" id="ADW68217">
        <property type="protein sequence ID" value="ADW68217"/>
        <property type="gene ID" value="AciX9_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1154"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_0"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="363" mass="40667" checksum="6DF3ACFBB3FBB5A4" modified="2011-04-05" version="1">MANVLDLRRRIRSVKNTRQITKAMKMVSAAKLRRAQERAMQARPYAQMLVNVLESLVRRTDLYNDVTGNIMHPLLVEREEKSVLLIVIAGDKGFAGGFNSNVGKAAQKFIDLRSAKGQNVDLEPIGRKAIGFYKKRYYAAQYDKTEEHYDNDLSTHYETIRQRKGQIEVAAEHADLLLKAEFSAVTEMAKSIIARYERAEIDSVYIVYNEFKSVLSQRIVVEKLLPIIKLGTHTIESSEEMTEEQRDAAVKAAEAEGISVHEPAGTAMDEEAKKFGTADVDYIFDQSPEELFRHLMPRYVTTQIFHALLESTAAEHAARMTATDAATKNAGDLIDSLSLTMNRVRQAAITKEIIEIVSGAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N6</accession>
    <name>E8X3N6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase, sigma 54 subunit, RpoN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1164</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579550.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1164"/>
    <dbReference type="EnsemblBacteria" id="ADW68227">
        <property type="protein sequence ID" value="ADW68227"/>
        <property type="gene ID" value="AciX9_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1164"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_0_1_0"/>
    <dbReference type="OMA" id="ENPHIQL"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="11">
        <location>
            <begin position="119"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="10">
        <location>
            <begin position="411"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="570" mass="64466" checksum="75DAE28A86A23915" modified="2011-04-05" version="1">MYLQPKLNLRVSQRQVLTPGLVQMVSVLALNKLELKDMINSEMVENPVLEELEESAASLDERTGIEGDRERSAEAVADEKVREEKDPFDEIDFGSYFQDYLDPGYKTASNFEEFDKPSFEHFLSQPSTLSDHLLWQLGSLTLKPDVRGAAELIVGNLDMNGYLTASEEELAEALGEALRAQVLPEPIPFDRHRVKGGVLVEEAVEPGVVQALAAEAVGGREFKAELKAVKTALEVVHALDPVGVGARDLRECLLLQIDAQKHEAEMMLRRRAKYADRVKLRAEAEDWGEVEVESAAAIDERGGDVFGTARHIVAQCLGLLQKKDMRELTKSCGKSPDEVQAAVEFIRTLDPRPGQRYNVSETRLIEPDVAFVKRDDVYVVVMNEEDMPTLRLNQGYRKMLKQKQTEKEVKDYVKERYKSAIQLLRNIEQRKNTIVRTCESIVRRQSEFLEHGESSLKPMMIKEVAEEIGVHPSTVSRAVANKYVHTQQGVYELRFFFSEGVNGPEGGDLPLVLLKRKVKKLIEEEDPRKPLTDDHLAAELKAQGINVTRRTVAKYREDLQIPSTHQRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P1</accession>
    <name>E8X3P1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69319">
        <property type="protein sequence ID" value="ADW69319"/>
        <property type="gene ID" value="AciX9_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2281"/>
    <dbReference type="eggNOG" id="ENOG502ZCIF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972423_0_0_0"/>
    <dbReference type="OMA" id="LMNIFCH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="32920" checksum="E5F1C6C56F35C666" modified="2011-04-05" version="1">MWSEEEMRDIEPVRPTPRRTNSPAIRQDLIRRNLTRAAAHPHDQTRSSIIYAPTETAHGNFIDASYRRIQATPDWQRRLTKPHTAKRHGRLSEVRDTSWCELDTATSSDALLMNIFCYPRVLATASLPALLGIDPGQTPIFGHKPHTPLHRNLTDTTEIDMKLGPLLVEAKLTETDFQSAPIRKLQRYRDLEEVFNLEDLKAEQGTIRSYQLIRGVLAAHVHQASFCVLCDARRPDLIESWFQVMRAVRFYDLRARLRIHTWQELARALPVPLKVFLAQKYGIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T8</accession>
    <name>E8X3T8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2329</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2329"/>
    <dbReference type="EnsemblBacteria" id="ADW69366">
        <property type="protein sequence ID" value="ADW69366"/>
        <property type="gene ID" value="AciX9_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2329"/>
    <dbReference type="HOGENOM" id="CLU_3234229_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="43" mass="4814" checksum="F0775BA4AAD67697" modified="2011-04-05" version="1">MRVSREPNLRIGRNLAAHKSKVKPTNGLYAILTHVIANTLVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W4</accession>
    <name>E8X3W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3467</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70472">
        <property type="protein sequence ID" value="ADW70472"/>
        <property type="gene ID" value="AciX9_3467"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3467"/>
    <dbReference type="eggNOG" id="ENOG502ZMRH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2734378_0_0_0"/>
    <dbReference type="OMA" id="EKLAHRM"/>
    <dbReference type="OrthoDB" id="2079142at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7968" checksum="BF7281B029B9D3D6" modified="2011-04-05" version="1">MTKTNGQPSPTLEQRLRAAAGDVEVELKRLITYVNDEVVPDVRRNGSHALRVASVELEKLAHRMDEANRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X447</accession>
    <name>E8X447_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0016</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578436.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0016"/>
    <dbReference type="EnsemblBacteria" id="ADW67107">
        <property type="protein sequence ID" value="ADW67107"/>
        <property type="gene ID" value="AciX9_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0016"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_5_2_0"/>
    <dbReference type="OMA" id="CFFCLGV"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25357" checksum="3C2FB4D4905A83E8" modified="2011-04-05" version="1">MKVMLFGGTGMVGQGALRECLLDPSIKEVVAITRSTVAQPIPTPSPKLRQIIRKDLFDLDGLDDEFAAVDTCMFCLGVTSFRMKEDDYRHITYDLTLSVAKRFVRVNPKVVFIYVSGAGTDSTGESKTMWARVKGETENDLLALPLRAAFMFRPGGIVPQHGIKSKTAVYQVFYSILKPIMPLFERFFPKYVTTTDQLGGAMLRLAKKGVAQEGPPRRVLESVDIARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X457</accession>
    <name>E8X457_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0026</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578446.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0026"/>
    <dbReference type="EnsemblBacteria" id="ADW67117">
        <property type="protein sequence ID" value="ADW67117"/>
        <property type="gene ID" value="AciX9_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0026"/>
    <dbReference type="eggNOG" id="ENOG502ZCRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2752159_0_0_0"/>
    <dbReference type="OrthoDB" id="1992607at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7878" checksum="D391F5E5EFC383FF" modified="2011-04-05" version="1">MNGREIERLLTMIDANIAANQTILKDEMLRFIESHEDQVVNELRAHESADIPTSAGVMTIKLSDLRELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X468</accession>
    <name>E8X468_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0037</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578457.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0037"/>
    <dbReference type="EnsemblBacteria" id="ADW67128">
        <property type="protein sequence ID" value="ADW67128"/>
        <property type="gene ID" value="AciX9_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0037"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283822_0_0_0"/>
    <dbReference type="OMA" id="DPYRDEP"/>
    <dbReference type="OrthoDB" id="956262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233653" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="4">
        <location>
            <begin position="70"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119562" checksum="C4428F7E55E760EF" modified="2011-04-05" version="1">MQTSHLSSTLFLCFASFVSATLPAQQLPADVTVQKLPISPPPSSPASAASEYAGESAVVDRSELIYAMNADGTGYSEHSMAIRVQSEAAVRELGIVNVPFASASEKVEIQYVRVRRPDGTVLQTAVSAALEQPQAVTREAPFYSDLKQMQLPVKSLRAGDTLEWKVRITRTKAEAPGQFWSQDTFVSQGIALSETLELRIPKDTSVNVWTNPALNLKPIEKVDGNQHVYRWESKSLKPTTGPEAEAEKKRKEKELWTADQELDAKEGALPSVAWTTFKSWEAVGAWYRGLEGDRMMPDDTLKAKVAELTAGKTTLEEKVRAVYGFVGPQVRYIGVAFGVGRYQPHHAEEVLENQYGDCKDKHTLLAAMLTVLGLHPDAVLIGSGIRFNEAVPSPAAFNHLITHVMIDGKETWLDTTAEVAPYRMLNSTIRDKQALVVPETGTAKLEKTPADPPFPSYQRLKAVGMLDQDGVSNSRLVLTVRGDDELVLRAVLHQIAPAQYDELTQRVSQSMGYGGTASHAEISRPEDTAGPLEMSYDYKREKAGDWNNYRIVAQLMPVSLPMVDEKDPPVQSIDLGVPRILSSTAEMKLPSGWGVELPEAIHEKAAFATYDMSFRFDKGTLYSERKVVVLQQKIGVKDWKSYKKWQDAVGLGGDPFIQLTRVDARTDHASGKEGGTSNGPPAPAVTNAEAVKLIQQAFTAMRKMDVGEAQPLLDKAKGLNDQERLLWAGYGYLAELRGAEQEAATDYRKELSLHPDSYQVYRSLVGSQLRSGKRKDAMETLRSWQTADTSDPAPAMQLSAMQLADGNASAAVETMNSSIAKLPEEKRTEPRVILALCQAEMKNGMEAKASASMLELLKTSEDSGVLNDAAYFLSETGHELPASETAMHKALSQMNAETESWTLDESPQVLAQQTSLLIAAWDTMGWILFHEGKLSEARSYVEAAWVNEGHAVVGEHLGDIQMAMGEFTLAIQTFELAKKGGGPASELNERQNNAKKAGGKSTSMDAGKELKELRTVKLGSSKGHDGAAEYKVLLADEKVVRVEATGAKTVEGGAEMIEKMQLPQMFPKGSTARLAKSGLLDCYEETCAFIFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D4</accession>
    <name>E8X4D4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ordered locus">AciX9_1198</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1198"/>
    <dbReference type="EnsemblBacteria" id="ADW68261">
        <property type="protein sequence ID" value="ADW68261"/>
        <property type="gene ID" value="AciX9_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1198"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_0"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="14"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="543" mass="57427" checksum="1628CC6065CE350A" modified="2011-04-05" version="1">MNNIECITDAVHDPAIDLKPVRRALLSVTDKTGLVEFARALAGHGVELVSTGGTSKALREEGLTVRDISDLTGFPEMLDGRVKTLHPKVHGGILHIRGNEGHVASVTEHEIQAIDMVVVNLYAFEKTAAKVGVSAAEIIENIDIGGPSMVRSAAKNFEDVAVVTAVADYAGLAEEMAANEGQLGRATRWRLAKAAFSTTAAYDAGIATALEALVVTDNPHDAAVFDKEALPKTVRVIEPQSVVLRYGENPHQLAALYSDGSGKGVAGAKQLQGKELSYNNLVDLDACWELVSEFDETAVVIIKHTNPCGASTGDSVLDAYTRALAADPVSAFGGVLGINREVDGAAAEEIAKLFVEAIVAPSFTADALARFGAKKNLRLIQIAPAETPRVIKQISGGLLVQTADRKHITAEDLKTVTKRPPTPEELRALLFSWSICKHVKSNAIVYGRFHEGHGQTVGIGAGQMSRVDAARFGAMKAVLPLSGTVAASDAFFPFPDGLEVVAQAGATAVIQPGGSMRDNEVIEAADRLGLAMVFTGVRHFRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G5</accession>
    <name>E8X4G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579615.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68292">
        <property type="protein sequence ID" value="ADW68292"/>
        <property type="gene ID" value="AciX9_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1229"/>
    <dbReference type="eggNOG" id="ENOG502ZAJX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500349_0_0_0"/>
    <dbReference type="OMA" id="SHRIWEL"/>
    <dbReference type="OrthoDB" id="300570at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="544" mass="57664" checksum="97F3457810D95C06" modified="2011-04-05" version="1">MTTIRSTWTRPAPTLTGLLPSTAWSGSATMPIPHGTLMAQNDATTLSIGIDITDETGAANPDDYFWFIVDINDNGVIDSKRDILFGEWPGNPNRLGLWYMAAPNETWPAPNTQVIASKVMQGFGASTNSATAHRQWQITFTLNELGITLDPTAPAPVVRFGLRIATLSAAFLGETPPTPLASFTNFNEIILSTAPTLPATGPSGPVIASIGLIGTGLIGADGYCNVPATYIIKPVEAAFSGTLNFISNVGAVTSLWAAGATKYKVFRRFGLTPAAAAAAPWLPILQAWTNFEVVGTTDVWQSFGPDSAGFYPLVNPGLSYTTQDLIFQWSTGAESDGVHQFEFAFFNASGTSIASTPQIVTLKLDNQAPIVDLTNVLHAGAPVASCAIVNLTSITDGVQIQYEAFQPEGDLESFALTALYGHGQYSPIYSDAYAAHASPTHIWQGVSTDTQPVPPALWVPPGTCAYLFQIQAWSRTTDGYSYPVIQSTDFQTVTLIKPGIILKPLPILAPIHATPTGFGPPPVLGTTTLAPVSVLPPAVEPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I8</accession>
    <name>E8X4I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2361</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2361"/>
    <dbReference type="EnsemblBacteria" id="ADW69398">
        <property type="protein sequence ID" value="ADW69398"/>
        <property type="gene ID" value="AciX9_2361"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2361"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_1_0"/>
    <dbReference type="OMA" id="TPRWLFV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="152"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="532" mass="59387" checksum="6877091539ADB5E6" modified="2011-04-05" version="1">MSVHLINPSDNSFGTAVITPRWLFVLAAATPSSVGDPILVDESIEQVVPESIAPGDIVGISVHTGNALRGYAVGRMARERGATVIYGGIHATLFPEECFERGQAHSVVKGDGDVAWGMAVNDSLNGTLQHIYDGGRIEGNQFLAARWDLMRTDKYMWASVQTIRGCPKHCSFCSVWRTDGQKPRQRQFQSVIDEIVNLRRIGFRFIALADDNFYPVTLTDLRLAREQGNQAKLDELIAIRSERFQLMEELSKLPKDMVFFTQITMEAGEDGDYLDAMRRANIKGALVGVEAVTPEGLKAVFKDFNYSGEALAKQLQTFKKHGVHVLGSFIFGLPTDKPATFDATVEMALKAGVTFAQFVMMTPFPGTVDFGRWEKEQALNPTLVGDIPITRYWLIPTEIRPKMFTPHPSMSSGEISERTQKVWDRFYDWGAIWERSSCTPNLKSRLAFILLSKLYRQMYAGTGISTDSARRKKSKKAARWTAAQTRKIFQAKPMPELQAPAWELAFKSPLSTRPAFLRQAVAETGPFAILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K1</accession>
    <name>E8X4K1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2374</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2374"/>
    <dbReference type="EnsemblBacteria" id="ADW69411">
        <property type="protein sequence ID" value="ADW69411"/>
        <property type="gene ID" value="AciX9_2374"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2374"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_0"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="54"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="445" mass="48703" checksum="D97E39FC0210B63F" modified="2011-04-05" version="1">MSLFDTSPLAPASPGRGTAPLAERMRPRDLDEYAGQQHLLGVGKPLRLAIERDDPASMIFWGPPGVGKTTLAKIIAQKTQASFIEFSAVLSGIKEIKNVMVEAEKASQFGSRTILFVDEIHRFNKAQQDAFLPYVERGTIRLIGATTENPSFEINAALLSRCRVYTLQPLSEDEVIALLRRALADSEYGLGESGVEADEDALASIAAYASGDARTALNALEVAAQLATGRGETTITKPLAAEAMQRRMLLYDKKGEQHYDIISALHKSVRNSDPDAALYWLGRMLEAGEDPMYCARRIVRMAVEDIGLAAPEALNLCLSARDAMHFLGQPEGGLALAQAVVYLALAPKSNAVYVAYGQVQADIQRTVAEPVPIHLRNAPTKLMKELDYGRDYQYAHDVEGRVADMECLPPSLAGKRYYVPTGEGRERQLAQRMEEISRIKAAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L7</accession>
    <name>E8X4L7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">AciX9_2390</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580743.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2390"/>
    <dbReference type="EnsemblBacteria" id="ADW69427">
        <property type="protein sequence ID" value="ADW69427"/>
        <property type="gene ID" value="AciX9_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2390"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_0"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="271" mass="30054" checksum="A24116EFD57A2979" modified="2011-04-05" version="1">MSQIRKPKLGQNFLVDDDARHRIAGSLGDLSTRTIVEIGPGHGAITEILATRCRRLIALELDRSLAAELTFRFRENPNVQVIETDVLKFDFASIAEEGETLDVIGNLPYYITSDILLHLFAAAPLLRRAALMMQREVADRVSAHPGVRDYGLLSASTQMYAQVDNLFTLPPAAFNPPPDVFSTVLRLSFAPRFTELGVDPIGFDRFLRKCFAQKRKTLHNNLRVAGYSPEALAQWPATIPPQARAEQLSLEQMSTLYGALLAFCGDENAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L9</accession>
    <name>E8X4L9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ordered locus">AciX9_2392</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580745.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2392"/>
    <dbReference type="EnsemblBacteria" id="ADW69429">
        <property type="protein sequence ID" value="ADW69429"/>
        <property type="gene ID" value="AciX9_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2392"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_0"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW69429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="18198" checksum="15D4526EE24193E6" modified="2011-04-05" version="1">MRVFGIDCGTEFTGYGVVEMDARARNSRLVHCAAGTIRLNKKEATPTRLVKIFGELTAQITLHEPDVVAIEEVFFSANAKSALKLGQVRGVAMLAAATCGKPVVEYAPLSIKSAVVGYGLAAKEQVQFMVMRLLALETAPDSADAADALAIAICHLHTAQTLDLQAGAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q2</accession>
    <name>E8X4Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3536</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581852.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3536"/>
    <dbReference type="EnsemblBacteria" id="ADW70541">
        <property type="protein sequence ID" value="ADW70541"/>
        <property type="gene ID" value="AciX9_3536"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3536"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072073_0_0_0"/>
    <dbReference type="OMA" id="HEFAVQF"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="26019" checksum="352BB807DA7EA805" modified="2011-04-05" version="1">MGSPAQEADLPEPAKVKKSEETRTRILEAALAIFKERGFEKATMREIATEAGVAVGAAYYYFDSKDALVMAFYERSQMEMHPSMEAGLDRARTLEARLRVIISTKFDYFAPNRRLLAALSAHTDPEHPLSPFSAETVAIREQDIASFERAVSESGVKLPATTAPYLGRLLWMYQMGLILFWVYDKSESQSRTALLYEKTLKMLLVTLKLAGIPLLRPLHRLAGELLAVIYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W2</accession>
    <name>E8X4W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative histone H1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3598</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581912.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3598"/>
    <dbReference type="EnsemblBacteria" id="ADW70601">
        <property type="protein sequence ID" value="ADW70601"/>
        <property type="gene ID" value="AciX9_3598"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3598"/>
    <dbReference type="eggNOG" id="ENOG5033CBF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149185_0_0_0"/>
    <dbReference type="OMA" id="KVGRAMK"/>
    <dbReference type="OrthoDB" id="2078040at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045468">
        <property type="entry name" value="DUF6496"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20106">
        <property type="entry name" value="DUF6496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="10429" checksum="AE26A8BCE2961C3C" modified="2011-04-05" version="1">MATKKSAERKYSPAASKNVETEMKEMKAGKLKSGSGQKVTNPKQAIAIGLSEARKAGKKVPPNPNVPAKKTAAKKGAAKKAPAKKIAAKKSTAKKTATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y2</accession>
    <name>E8X4Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0083</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0083"/>
    <dbReference type="EnsemblBacteria" id="ADW67174">
        <property type="protein sequence ID" value="ADW67174"/>
        <property type="gene ID" value="AciX9_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0083"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="124"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="39648" checksum="041CB743760AE28D" modified="2011-04-05" version="1">MNVKHKGEFQRRKYLQDHCGPYLGLVSEYLEGVAKLRYRNVGLVRKLLCPFFRFLWERGIVSLKDVVPATVTAFQVWARENGFASAATDTSALSVFFQWLIVEERYFEDSPVIPAIHGKRKRARTGRPYSQEDISQIRQLLDVRGNERLRAFFEIANESGLRKSEIYRLRLEDLVIEQRSLKVGLPNKSMTERLAFFGDRASCRILEWLSVRKPDCGHGFLFHNHYGAPLLRNTTQEEFKRILCKMYRGRMAHETGLETFSIHRLRHTLASKLASNGADANTLMNVLGWVSPSSLESYTRLSEEAKVQGFVWASERAEQQLKNGTGKRTLTAEEFLNGVPDLCAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X518</accession>
    <name>E8X518_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0134</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67210">
        <property type="protein sequence ID" value="ADW67210"/>
        <property type="gene ID" value="AciX9_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0134"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439231_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="21186" checksum="E302EB09FD911F8A" modified="2011-04-05" version="1">MTSLNRVYMQRVGILRTAFSMGAEPFTAVDWMSQDPNFSGLCRLFSRCLGRLVNTVRVVNNLELGICPFRLIGQTTAHFPDFSLWLRTSHPLQRAGQSLKFFVSKAAVGWAVLTTDQDILPFISESTLTTSITQTLNAWRRVQQETSYEGPFQDEVNRSTNREFGLAETESRDPRSNPESTLSSSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P0</accession>
    <name>E8X5P0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane protein assembly complex, YaeT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3666</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581976.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3666"/>
    <dbReference type="EnsemblBacteria" id="ADW70667">
        <property type="protein sequence ID" value="ADW70667"/>
        <property type="gene ID" value="AciX9_3666"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3666"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_1_1_0"/>
    <dbReference type="OMA" id="IEWISPM"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="357"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="439"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110712" checksum="E8D0677EC7C4DED4" modified="2011-04-05" version="1">MRIFTVKRASDSSIKQQNEPASGVSGPQAHPTMQPIHGSIQASASRHRSFAYSLAALIVLAAGLPCMDVAQAQTAPAAAETQAADLQNGNAQALCQPQVIGNRRIPKESVLARLFSRQGNLYDPAIVERDFNSLWNTGYFENVRIERVDTPACVQLVIYVQEKPTIREINYKGLNAVSLSDAQEAFKKAKVGLTVESQYDPTRIKRAETVLKELLSQHGHQFATIKSEVKTIPPAAVSLTFNVKEGPTVKVGKIVFDGNNSIPDRTLRASMKNLKPIGVPHSIVLENLLARTFDASKLDEDAERVRVAYRDKGYFKAITAEPVTKIRDTSSFNPFLLKPTVGKRIDILMPVEEGDRYKLGGITFKGNAHVPNTRVLRAQFALKDGEYFNASLFGKGLTQLQKAYGELGYINFVGTPAPRFDEAKKLIYLDIDIDEGKPFYISRIEFTGNTITRDKVIRRELLVEEGQVYNSRLVDLSLLRLNQLNYFEALKSDQDVESRQNADDGTVDLLVKLKEKGKNSIGLNGGISGLSGTFIGLNYETNNFLGLGETLSVQANVGDLSRNLSFGFNEPYLRNKPISVGVSVFTTKYDFNPSKSYGATGTSNLSAAQNSQLANYNQATTGFTTSLSEPLRHLLARTGVARAGVSYSLSRSSITTFNDNTRNVFQNLSFRSGVAGLNQLSGIVTSVFTPTFTFSSLDRAQGPHSGRDFNAQIQIAGAGGNVKYYSPAIAFRQFYPMKGLKINREGHNVLGMRVQLAHVGGFGGEVAPPQQRIYGGGESEVRGFDVRASSPYVVIPNRVQFNLTNPDGSTIPRDPSNPSLGNIQIPIPVYRLQPIGGDTQLTSNLEYRIPIVNQVTFAFFTDFGLTFNTQDSQLRQSVAGLSTLNSPSYGCPTFVNGACFGGQSVTFSQYLHTASGTNFVPRMSNGAELQVILPIVNAPFRIFYAYNPLRLYKDLPMQLPVSLGTFRSYFPNTGAGQYSYQQAVQLYGADYVLREPRKTFRLTVSTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S1</accession>
    <name>E8X5S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion protein, VC_A0114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4009</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572717.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70805">
        <property type="protein sequence ID" value="ADW70805"/>
        <property type="gene ID" value="AciX9_4009"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4009"/>
    <dbReference type="HOGENOM" id="CLU_031690_3_1_0"/>
    <dbReference type="OMA" id="MIAMSWH"/>
    <dbReference type="OrthoDB" id="496911at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="50296" checksum="A707A44527A8808B" modified="2011-04-05" version="1">MKFLSRVVWSEGMHLGPHHFQTQSRYFEDSLWFLSAGLRRNPWGLISLSLDTEAIRNGNVVLRYASGIFPDGLVFEIPDSDPAPPAVSLKDLFSPTDSEITLFLTVPKRSSRGLDCDTATLKSNAARYSSADRTITDDTSGQDEYTVAFGNKNLTLVSQAQLTPDAISFPLARIFRDGKGGFAVDPDFIPPALRISANENLLTLLKRLIETLNERIKTVSRGKKREGQFEIGSSSLDVANYWFLHALCSAIPSLQQHLDAKHSHPEELYLDLVRLSGALCTFSLESNPSDIPPYSHLHLQSVFHALDAHIRRHLEIVVPSNTLTLDFTKSEPYVFVANVNDERCFRRARWIFGIRSSLAESDLLRLTPHLVKICSAEGVTKLVQRALPGLELLHLSVPPSSMSAEADMHYFSISSAGACWQHILQTKRVGIYVPGDIRDAVFEITVILEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W8</accession>
    <name>E8X5W8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsular exopolysaccharide family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4066</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70852">
        <property type="protein sequence ID" value="ADW70852"/>
        <property type="gene ID" value="AciX9_4066"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4066"/>
    <dbReference type="HOGENOM" id="CLU_1832346_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="14693" checksum="43B717F64FC17031" modified="2011-04-05" version="1">MCRVSLGCAYALNGARVLLLEGDMRRPGLAANFTVASTGIGLSSILAGSATIQQAVQSVSEPPGLFILPCWTDSTIAHSDSHAAINLMRTLSEGYDIVIIDSPPALGLADSTLLAKFADAIGLVLSYTEFNKAQVRRAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y5</accession>
    <name>E8X5Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4088</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70869">
        <property type="protein sequence ID" value="ADW70869"/>
        <property type="gene ID" value="AciX9_4088"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4088"/>
    <dbReference type="HOGENOM" id="CLU_1118929_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="27577" checksum="A67CAE4564B82FD7" modified="2011-04-05" version="1">MNVGETTPPAASSVTPFVRWTAYGIALLDKQEFTAAAAAFRRTAVEYPKLADGCINEGIVLYTQGRYAEALKLFAAADAIAPENMRARYYVGLCYRWQYQYAKALAALVPVARAYPRFGQVDDDLGWIYLLNRRYPEARLEFEAALAVDPDDVVAHKWLSGMYTALGEKGLAAEEARQTAQTKDDPAALWRVLGYWRANLDVAREVTPGHIHGDEDGLNAETKQILNTQNPPSMVWIQHRGGYPLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X605</accession>
    <name>E8X605_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4109</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572801.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70889">
        <property type="protein sequence ID" value="ADW70889"/>
        <property type="gene ID" value="AciX9_4109"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4109"/>
    <dbReference type="HOGENOM" id="CLU_758127_0_0_0"/>
    <dbReference type="OMA" id="NVYRFEI"/>
    <dbReference type="OrthoDB" id="1226326at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="365" mass="40421" checksum="C7441256F8CAF413" modified="2011-04-05" version="1">MMQWILRSGQSRRPRWSILLGTEALLCLALTSCRRPSTKITFTQVPKTSLGGADTSGVISGRVTGPAEGSRILLYARSGGKWWIQPYGYIPYTVIAADGSWSNSSHLGTDYAAVLTKGDYDYQKMVPELPKVGGKILAVAITAASKNRFEPTRVDAATIHFGGYEWEVRSTISNNGGIDHQYLTKNVWLDSDGALHLRVSRVGTKAACAEIHTIRNLGYGTYRFTVQDVGKLDASASLGFFTWSDRSPDQNYREMDIHISRMGNPENKNGEYLIQPYYIPANVYRFEIPSGEITASFHWMPGSAVFTTAEGSNPHAKPVSTWTFTAGIPASSGENTYINFCEFPFAKVGLRQEAEVVIENFQFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X619</accession>
    <name>E8X619_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgI</name>
        <name evidence="4" type="ordered locus">AciX9_4123</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572815.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70903">
        <property type="protein sequence ID" value="ADW70903"/>
        <property type="gene ID" value="AciX9_4123"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4123"/>
    <dbReference type="HOGENOM" id="CLU_045235_1_0_0"/>
    <dbReference type="OrthoDB" id="693640at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="382" mass="40126" checksum="6DBE109BEA0013A2" modified="2011-04-05" version="1">MKLSLRSHLLIRITHVLFLGLLALSFAPLALATQPERQVLLRDITDIEGVRDNQLVGYGLVVGLRGTGDRQQTYFTVQTLANAMKRMGVQIAPGQVVVKNVAAVFITGSLPPFARPGSKLDITVSSAGDAKSLEGGVLLMTSLRGPDGQVYAEAQGPLALGGYSEGTAGQLHSVNHPTVGRIPEGAIVERDANVDLSHFHTVSLMLRNPDFTAARDMAEAINKDFQHTVATPIDSRTVQIDVAGAGASSVPILISRVQSLSIPFHSPAKVTINERTGTIVMGGSVTLSPVSVLHGSLSIEVETTYTVSQPLPFSSGGTTQPVANTVLAVKDLPAQSIRLENGANVDDLIRGLHAIGATSHDIVAILQAIKSAGGLQADLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V4</accession>
    <name>E8X6V4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582272.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71254">
        <property type="protein sequence ID" value="ADW71254"/>
        <property type="gene ID" value="AciX9_3980"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3980"/>
    <dbReference type="HOGENOM" id="CLU_037209_0_0_0"/>
    <dbReference type="OMA" id="CITCHSP"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="403" mass="45304" checksum="016B46233728CD6A" modified="2011-04-05" version="1">MRDRKIASTVIAFLITVILYATAVGQTPKATFVGSKSCRACHADTYDSWQKTRMANVVQDPKIHPEAVVGDFTTPNPLVTFKLDDVAFTYGSRWKQRYFTKRGDDYYVLPAQWDIQKKRWLPFHVEKGTDWWVPHYGESNMERPTSTLCDGCHSVNFNIETKQVTEWNVGCEKCHGPGSLHVAHPTKQNIVNPDKLDSVRGNDTCIQCHSQGQPVGNPIAGKYYDWPVGYLPGARLVDYWKLEELKPGVTGFYQYADLTAHKNRMQGNDFVQSNMYHREIRCSDCHQVHSNTVSNLRMPSNALCLGCHTKENPAGLKGTVSEHTHHAEGSKGSQCVACHMPKIEATIKDSFVSAHTFRFITPAQTEQSGIPNPCTSCHADKSTTWATKELIAWTSVSPWRVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z4</accession>
    <name>E8X6Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3817</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582125.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71103">
        <property type="protein sequence ID" value="ADW71103"/>
        <property type="gene ID" value="AciX9_3817"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3817"/>
    <dbReference type="HOGENOM" id="CLU_002934_7_1_0"/>
    <dbReference type="OMA" id="IMGDDVR"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230302" evidence="5">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="309"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="51033" checksum="A6B2DCEA30AF1F47" modified="2011-04-05" version="1">MKRMRLINTLLAACIVSTLASAHAQNVTDMKPSPQQTEWQDLEFGVILHFSTNTFLNREWGDGTASPKVFNPTQFNPDQWMKAIKASGAKYVVMVAKHHDGFCLWPTGQTDYSIKQSPWKDGKGDMVREVANAARANGLKFGVYLSPWDRHEPKYADPAAYDKYYNAELEELASRYGDLVEFWLDGAGSTGRTYNFAKIIETLRTYQPNTIVFADIGLFEYGDARWAGDETGKIEYENWNVIDRHGVLRWRPVEVDTPLRKVHWFWHPNDEASLKSTAELLDSYENAVGHGGQWMLGVAPDDRGLLPDADVKRLQELGTALQTRYGKSLLTPHLPTDANIARALDTDPDTFWTAPAGTHTGTLEVNMPKPITFDHTLIMERLDEGQQVLRYRIEIWKNGAWTSVAQGSAIGHKKIDHFPAVTAQRIRLNIISSAGDARIREFQAFLENDPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A4</accession>
    <name>E8X7A4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1731 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4387</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71338">
        <property type="protein sequence ID" value="ADW71338"/>
        <property type="gene ID" value="AciX9_4387"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4387"/>
    <dbReference type="HOGENOM" id="CLU_1616691_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1731" evidence="2">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="17613" checksum="A53869509B2A4437" modified="2011-04-05" version="1">MSATAKQELESQGTFFSPPPAKREPKVAAPTAEDAASLAGVIESSIDPDLTADQAEALRRIEAACEPGESYLLTGHAGSGNVVAPQQVTSKAFNRLIGKAVDSKVRIRLPAWPFRLLLGQLADETILGSVRAMPGRLMRDGLVFHCNTLDVALARMNLRQPRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F1</accession>
    <name>E8X7F1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4439</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71385">
        <property type="protein sequence ID" value="ADW71385"/>
        <property type="gene ID" value="AciX9_4439"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4439"/>
    <dbReference type="HOGENOM" id="CLU_2206322_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="11825" checksum="0A788EC9EAB274D9" modified="2011-04-05" version="1">MTITNTFKDLAGGGLDVFTPKASSSQEDAPSAKQLEKVAKDAGFALDNLPVTRRVLKSGRVASKERAQPMTLRIRVNDWNRFSSFCERNDYTVAEGFERLASLADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G7</accession>
    <name>E8X7G7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4455</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573120.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71401">
        <property type="protein sequence ID" value="ADW71401"/>
        <property type="gene ID" value="AciX9_4455"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4455"/>
    <dbReference type="HOGENOM" id="CLU_158535_0_0_0"/>
    <dbReference type="OMA" id="FRNTTRC"/>
    <dbReference type="OrthoDB" id="1702091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14384" checksum="1B3E7152384EE52F" modified="2011-04-05" version="1">MNATEATKHLGIGERIRRSSGRAGRRTVASTKVTLQEHAELEAAAKQEGKVLSEWAREVLLEKARTGPTGTAVFTELIALRLLANNVLRSIALGKVMTEKEYAQVLSEVKNGKRITAAEILTQYRNQEGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I6</accession>
    <name>E8X7I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="10">3.4.24.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_4474</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="10"/>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573139.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71420">
        <property type="protein sequence ID" value="ADW71420"/>
        <property type="gene ID" value="AciX9_4474"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4474"/>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_0"/>
    <dbReference type="OrthoDB" id="305005at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="9">
        <location>
            <begin position="153"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="8">
        <location>
            <begin position="579"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="769" mass="86966" checksum="53F79AA39AD4F7C5" modified="2011-04-05" version="1">MKDIPTLANPTISQSARMRRLGDKVLGPEMGLDNGGAMTHSIRFAQTRPIVFVANQPRWSQRDINSHKRLLVFSMSTLPCGFSADVQEEVILKFTKPMKRVLHRKPFAIAVIVVSSAFSLLAQRPMSPLVAVTSPRHGTWGFDPRGMDPSVKPGDDFFSYANGAWIRKTNIPPDQTSVGPFSDLRRLCAEQVHLLLETTQDNRSDSDEGRVHTLYQAFMDDSSIEQAGAHPLQSDLQLVRKVGNRADVARLMKRHGFEASLFDLEIEKDEKHPDRYAVHLGQGDLGLPNRDLYLDAQFTDKKRLYKAYVAEMLRLAKWPNANKSATAVVAFESLIAQASWRGEDLRDNSKSYHSMSLANLRRMAPMFPWADFMAGDHLSENDFLIVTTDTSVVKLAELYGSTPLSTLKAWEAFRMTDAAAPYLSNDFRQARFAFRGNALNGLEAPPSERWPGAVSLLNALMGSTVGKMYVAAYFPAERKMAVQAIADSVMQALRSDLAQLTWMDPITRAKSLRKLDDIAVQMGYPDHWRSYAGVNLNKQTLYKDVETLRNHNWNYQVSQLKMAWNKNDWRFWPQEPVAYTENGQLIFPAGMLQAPFFTAQADAAVNYGSIGHVIGHELTHPFDDRGDWWTPEDRQRFKERSARLAKQYSAMEPLPGVHIKGELTLIENVADLGGLSLAYKAYRTTLSHDEDAVERDFTRDQEFFLGYAQVCREKERPDSLRNRLASEVHSPAAARLNGVVQNMPEWYKAFNVNPGERMYIVPDERVAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T2</accession>
    <name>E8X7T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4586</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4586"/>
    <dbReference type="EnsemblBacteria" id="ADW71516">
        <property type="protein sequence ID" value="ADW71516"/>
        <property type="gene ID" value="AciX9_4586"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4586"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321790_0_0_0"/>
    <dbReference type="OMA" id="CHISGRV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="900" mass="98417" checksum="151644BDC721A417" modified="2011-04-05" version="1">MNCSATASFALVVVGAGPAGIAPLLAASKEEKLGDLLKAGVIIIDDSDRIGAGTIGSYAIRSDSTALAILDIIMRPHDDAFTALRDNPIVLEVAAYGNDAVPLSLAGEFLHLLGTTVLDLVAASPRGRILRNTHALFVRQISPHEWDTHVFDRDRGIAEVLRSSSVVLATGAHQPEARLFLEAVAGQPLLPRYKGRVLQSGYALTSVGLSDIAARLEDREQARIVIVGGSTSAGAVAHAMLNRLPSSSQFGPESITILHRRPLHIFYSSVAEAEADGYTEFGPLDVCPLSGRVYRLGGFRLDSRELIMSVRGIGGRPPEPRVRLQLISPEKSFQCQKLLDEADVIIAAMGYLPRALPIFDEKNQPIALMLERNGSNRLVDAYCRVLDQHGAAISGLFAIGLAAGHPPDRELGGEATFEGQINSLWLWQHALGNRIVSQVLDRSRTLLVPQSKAPLPTLVTQVQAKPQVRHIQEDLVQVPFLESPRLQIERRSHSRHILPPDAPLPLIRPNPPKLSHNGAALAAIEDSGIYSNYGPVNSRFELALIDKLFIRGSCLTVCNATIGLMLAIREVIEERQSPKRRFALMPSFTFAATAHAAVWNGLIPLLCDIDPETWLPSHQAEELLLKQYKDQIAVIIPYATFGNNLDLARYERIAKEQGIPIVIDAAASLGSLDERGLAFGTDFPWPVVFSMHATKIFSMGEGGVIYCSNAKRIDRLRSMGSFGFESPRVSTLPGLNSKLSEVSALTALLQLDQFDTVLERRKVLTRKYMQKLPGWQRQKLNGIPALSFESVLLPAPLVSFRASIIETLKEKGIGAGTYFSPHIAEHPYFIDRTVSGCLDVTADISSRILTLPMFDNMLERDIVFVCASLWNVLRTLQPNQETILDARDNPRRSLPSAKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T9</accession>
    <name>E8X7T9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4593</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71523">
        <property type="protein sequence ID" value="ADW71523"/>
        <property type="gene ID" value="AciX9_4593"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4593"/>
    <dbReference type="eggNOG" id="ENOG5032KRB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107177_0_0_0"/>
    <dbReference type="OMA" id="TYQISAF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230867" evidence="1">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="21351" checksum="6AC02215AAA068D7" modified="2011-04-05" version="1">MRTTLSVIMTTICGSAGLLPVAWAQAVPTASKTYQISAFGAGTGTYTGLAGGKNAGITAGVDLGIRSYFNLYPSIEIRGTYPFFKGNIGSVKNLLGGIQVAKHYGNLHPYLDIMIGRGEINYANGGYPNPEGTFQYLQSASTVISPGIGVDYTITRSFAVKADLQLQHYSTPVTTSGSFYAKPITIGVVYRLHFDRFGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V4</accession>
    <name>E8X7V4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573257.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71538">
        <property type="protein sequence ID" value="ADW71538"/>
        <property type="gene ID" value="AciX9_4608"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4608"/>
    <dbReference type="HOGENOM" id="CLU_825771_0_0_0"/>
    <dbReference type="OrthoDB" id="2139940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234283" evidence="1">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="35003" checksum="987DF9D9DF03677F" modified="2011-04-05" version="1">MHALFRILAIQLLALPLSAATPLQQATTSTAIQPAEPPLPPGSNYDPGIFQALLPPADLAYLQQFSGAPAKDLLRDKQFKRLMKLFVPGCIFHYGRDMSLPDALSMAFDGSRIPVELRDNRYLLVVGQQGPYLQGRGFLWIDLQTGIALGGFYFAPTNGEPTPALNLFSKQIKEDTLGLSQFPPAFVGDFIQWSTSARVGPVVTRYFITGNNKKILVEHDEDFCVSADGTVAPRNGVCEQLNAQAADLDVTAADYLDQVHHATNATAWMLSPSQVAWLSLRERTCGGVLDPLACRINITHQRIHVLTGRPPSRPHPVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X829</accession>
    <name>E8X829_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4684</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71613">
        <property type="protein sequence ID" value="ADW71613"/>
        <property type="gene ID" value="AciX9_4684"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4684"/>
    <dbReference type="HOGENOM" id="CLU_1141314_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="27376" checksum="45D6E85470BEDCA6" modified="2011-04-05" version="1">MRECWAASLGNCRGGISREHVVSQCLFSSGSITVKGLDWCAGEAKTIGIQGLTRNILCEGHNSDLSPLDAVALQTFDSFDSAIKLRDFRQQYSPKINWTLRTFDIDGKLLERWFLKTLINITLDKTWIIGTGERELGKPSIELIEIAFGLRGFSPNEGLLVSAHVGYTGDLRQGLSFTPLTEGGNLVAGRFSFACLQFLLNLSPHHLRFDGTSQLLHHLRWIYFAMTDSRKRSKQSHRIRFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X831</accession>
    <name>E8X831_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS204/IS1001/IS1096/IS1165 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71615">
        <property type="protein sequence ID" value="ADW71615"/>
        <property type="gene ID" value="AciX9_4686"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4686"/>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="142"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="402"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="58755" checksum="6ED6ECB97881A949" modified="2011-04-05" version="1">MISLGRVAGAIEMRLKTCRVSATCPACGTSCRKVHSRYGRRLADLPWHGVPVVIHLQTRRFFCLEPGCRRKVFTEPLPGTVSRYGRRSCRSSEALRWMTLSLGGRAGARLAERLGLLASRSTLLRELHHRRPAAVVQAPRVLGIDDWAWRKGHRYGTILCDLETRKVVDLLPDRDANTVAAWLRRHPGTEIISRDRGGIYAEAARRAAPQAMQVADRWHLLRNLSEALCRAIAPHHRLFSQAARASRLEDLAPAPPSVAPWSQRELLVQQANRQRRYERWQQVRELFLKTGAPDQELARQLGIDHRTVKKFRIAEVYPEAKPRVRESIVDDHASYLDRRLREGCRSSTILWRELRKLGFQGQVNSVRYWLRQRRSYRTRAASPPQRPALRASPRQVVWLILKAAPFAKDMLEEVYQTSPEISQLAQLATSFFRIFRERDLAALTPWLEAAHGTALAAFAAGLERDFDAVREALRLPWSQGHVEGQVHRLKLIKRQMYGRAGFELLRLRVLQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X842</accession>
    <name>E8X842_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase, LytS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71626">
        <property type="protein sequence ID" value="ADW71626"/>
        <property type="gene ID" value="AciX9_4699"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4699"/>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_0"/>
    <dbReference type="OMA" id="DCTIDDE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="266"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="365" mass="40867" checksum="4E764F44D6B74A1A" modified="2011-04-05" version="1">MPLKSGRGWLLYASGWVPYAASYFLIFRLQPYSPHSSYGQALLDAVVNVLPVALLGVAVFWLASRLRWPSRHPIRFAVAHLFGAVSFALLWWASVQTLMSLQTLIVTHRWRYNPWGIYAAQWQAFSGLMVYGTLIGFSYMVQAQERARLEERLRMEAEALRIRSDLSALRSQLNPHFLFNTLNSVIALVGTDSLKAEQALLSLSSMLRYALSSHSEIEEAEVTFEEELRFTEAYLSLEKLRLGDRLRIERSIDPATLLLELPSLTLQPLVENAIKHSISKRPTGGTLAIRASARHGDLNIEVWDDGEGVSSENIAKSSGLGLKTVRRRVELYYESLGSMTVSSTPEAGTTVSLRLPQDESLPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV75</accession>
    <name>E8WV75_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0176</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578578.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0176"/>
    <dbReference type="EnsemblBacteria" id="ADW67250">
        <property type="protein sequence ID" value="ADW67250"/>
        <property type="gene ID" value="AciX9_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0176"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="CVAVDFR"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="359" mass="39210" checksum="BD52028EF699D933" modified="2011-04-05" version="1">MKDKVPGGQAQPGQAKSVGLKQVAAHVGLSVAAVSRVLNESPAARSIPEKTQKRIQEAARLLNYRPNVLARSLRNKRTHTLGVMVPEVSDGYATLVLAGIEEALLRHGYFYFLVSHHRRKELLDEYQHLLVARAVEGIIVVDTVLHEKPSTPTIAVSGNHIRDGVTSVVVNHESAALMALEHLRALGHERIAFIKGQRFSSDTQARWDGIRHAARALKLTIKPSLVAQLEGDQPNHEPGYIATRALLETQEPFTALFCFNDTAAIGAVLAIREAGLRVPEDVSVIGFDDVESAAFQNPGLTTVRQPLREMGMLAAETILKQLEAGRESRIDPSAHIEQLVVEPKLIVRASTAPARNLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ5</accession>
    <name>E8WVJ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1384</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1384"/>
    <dbReference type="EnsemblBacteria" id="ADW68443">
        <property type="protein sequence ID" value="ADW68443"/>
        <property type="gene ID" value="AciX9_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1384"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_6_2_0"/>
    <dbReference type="OMA" id="HITIPNH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="9110" checksum="0A53B6F3FB65BE6C" modified="2011-04-05" version="1">MKTPRNLHGSKLVDHLVRCWGYRRAHQTGSHIHLRTDFPTGQTVIIPDHRPLKVGTLNSILDQVAYHRGVPRQDILRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU6</accession>
    <name>E8WVU6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3704</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582014.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3704"/>
    <dbReference type="EnsemblBacteria" id="ADW70705">
        <property type="protein sequence ID" value="ADW70705"/>
        <property type="gene ID" value="AciX9_3704"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3704"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_0"/>
    <dbReference type="OMA" id="SHRVPWK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="38020" checksum="4533FDA0A136E45C" modified="2011-04-05" version="1">MKQVLVTGGSGFFGGVLKRRLLAEGFAVVNIDLVQDPDHHANLTSIRGDIRDKPLLQRIFAENQFLSAFHCAAMLAHDTISDDELWTSNVDGTRNIAEACRAAGVSKMVNISSNCLWASNLGHEVAEDEIPAPVELYGRSKLAAEEALAEFPDLQIVTIRCPTIIDGGRLGLLAILFEFIQDGKRVWVVGDGGNRYQFIYAQDLAAACILTLGYEGSDLFHIGSDHVTSLRQVYQAVIDVAATKARVAQMPKAPTLLAMKLAHKLGVSPLGPYHYRMIAEDFIFDTRRIRERLGWAPTLTNNEMMVEAFRYYAASRKEIHARKDVSAHSKPAAMGVIRLLKWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW9</accession>
    <name>E8WVW9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3727</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582037.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3727"/>
    <dbReference type="EnsemblBacteria" id="ADW70728">
        <property type="protein sequence ID" value="ADW70728"/>
        <property type="gene ID" value="AciX9_3727"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3727"/>
    <dbReference type="eggNOG" id="ENOG5033559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2699542_0_0_0"/>
    <dbReference type="OMA" id="KFIAVTT"/>
    <dbReference type="OrthoDB" id="2063356at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="7781" checksum="66F785590F90E72B" modified="2011-04-05" version="1">MEQPVTNSSARRTEDIALDLLKFVAAQANVGLKGSASTTGFAAPSSAKPEDQVNNLLELYARCREAVESPSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW08</accession>
    <name>E8WW08_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67314">
        <property type="protein sequence ID" value="ADW67314"/>
        <property type="gene ID" value="AciX9_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0240"/>
    <dbReference type="eggNOG" id="ENOG50335XY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2304677_0_0_0"/>
    <dbReference type="OMA" id="ELRVRYK"/>
    <dbReference type="OrthoDB" id="1992571at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="10580" checksum="8647B2F0C060678A" modified="2011-04-05" version="1">MLSLLTSRLFASKIEDIPAVIAETATEALEAALPESQETALLRTLGWVSAGMGAVALGLFVGRELRQRYKFNRRTPYDFYAHSGDELQDMEFGVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW33</accession>
    <name>E8WW33_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0265"/>
    <dbReference type="EnsemblBacteria" id="ADW67339">
        <property type="protein sequence ID" value="ADW67339"/>
        <property type="gene ID" value="AciX9_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0265"/>
    <dbReference type="HOGENOM" id="CLU_2954052_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6725" checksum="8CEA336C3119FD06" modified="2011-04-05" version="1">MHVIKVTLILLGFWLVISFHFALILGSFIASSRVPPESELGRGPERLPKAKLYRLKIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW44</accession>
    <name>E8WW44_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0278</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0278"/>
    <dbReference type="EnsemblBacteria" id="ADW67350">
        <property type="protein sequence ID" value="ADW67350"/>
        <property type="gene ID" value="AciX9_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0278"/>
    <dbReference type="eggNOG" id="ENOG5033H7V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2935049_0_0_0"/>
    <dbReference type="OMA" id="NKEGHLN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="5925" checksum="BC87BFBD11724083" modified="2011-04-05" version="1">MSANDQPGGAKEPSGYNGDASTAGPGKTDVKSETPENKEGHLNPSAPEDANVTPGSAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW81</accession>
    <name>E8WW81_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1406</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579786.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1406"/>
    <dbReference type="EnsemblBacteria" id="ADW68464">
        <property type="protein sequence ID" value="ADW68464"/>
        <property type="gene ID" value="AciX9_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1406"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137728_0_0_0"/>
    <dbReference type="OMA" id="GEMHRRH"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="14896" checksum="DCB45B592AB525A6" modified="2011-04-05" version="1">MRTVVDTNVLLSAIIYSELGSASATNSLVIAAAFGTLTTSAICYAELARRFSNRRNLDALLEQFECAVRGVDESTAFLAGRLFEQYRERGGSRERILADFLIAADAILNADRLLTRDHRFFGTSFDGLVAVAPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC2</accession>
    <name>E8WWC2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1452</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579826.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1452"/>
    <dbReference type="EnsemblBacteria" id="ADW68505">
        <property type="protein sequence ID" value="ADW68505"/>
        <property type="gene ID" value="AciX9_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1452"/>
    <dbReference type="eggNOG" id="COG4922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073327_1_0_0"/>
    <dbReference type="OMA" id="YIQHNLA"/>
    <dbReference type="OrthoDB" id="1598464at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="28343" checksum="71FFEF77C45E9B69" modified="2011-04-05" version="1">MANTDIEKVLTFLHGLSSGDPELATAQIDPKRYVEHNPRSGDGTDGLRGFFIRSSKEEHHLQVIRAFHDGPYVFTHAEGVVLGQNIFFDLFRLEAGFITEHWVLSANSAHPNESGHTQTDGPTEADLSVDSDENKALVRRYYETVHVGGDHSKIPQYFEGDHCIRHEPGVRDGVSNFKQDLERLVKNRTIDEIKFVLGQGDFVFILANGTHQGEPCAYVDLYRVDGSKIAERWGFPEEIPSEADRKNSIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD6</accession>
    <name>E8WWD6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579839.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1466"/>
    <dbReference type="EnsemblBacteria" id="ADW68519">
        <property type="protein sequence ID" value="ADW68519"/>
        <property type="gene ID" value="AciX9_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1466"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_0"/>
    <dbReference type="OMA" id="APVPWFP"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023881">
        <property type="entry name" value="Thiol_BshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03999">
        <property type="entry name" value="thiol_BshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="43757" checksum="D213CB8E1D52A3C6" modified="2011-04-05" version="1">MTYEPPIPATPTDRRLKIGITCYPTYGGSGVVATELGIELAARGHDIHFITSSPPFRLTGRESNIHFHQVEVFHYPLFEHPPYDLALATRMAEVAEFYELDLLHVHYAIPHSVSAYLAKQMLAARGLHLPFITTLHGTDITLVGLDRSYLPITRFGIEQSDGVTSISSYLREQTEKLFHVKKPIEVIRNFVNCDVYIAKPDLIAEMRPRFARPEEKLLVHLSNFRPVKRVADVIQVFARVANAMPARLMLIGDGPDRSTAEYLARKLKVADRIHFLGKQDNVNELLPVADLMVMPSEMESFGLAALESMACRVPAIATRVGGVPELIEDGVNGLLFETGDVDSMAHSAIALLADPGRLEAMSAAARKTAQDHFCAYTIIGNYESYYRRILASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP2</accession>
    <name>E8WWP2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3787</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582095.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3787"/>
    <dbReference type="EnsemblBacteria" id="ADW70787">
        <property type="protein sequence ID" value="ADW70787"/>
        <property type="gene ID" value="AciX9_3787"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3787"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_5_2_0"/>
    <dbReference type="OMA" id="CIYKPTC"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8360" checksum="B8DF3F5B396BF0B2" modified="2011-04-05" version="1">MAGIRDTLLRAVFTLYKAVVSPILHSVGVSRCIYLPTCSEYAYIAISRHGLLRGTALAAARIARCNPMSKGGLDPVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ3</accession>
    <name>E8WWQ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0309</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0309"/>
    <dbReference type="EnsemblBacteria" id="ADW67381">
        <property type="protein sequence ID" value="ADW67381"/>
        <property type="gene ID" value="AciX9_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0309"/>
    <dbReference type="HOGENOM" id="CLU_2508069_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9828" checksum="416C8252A3A7BAEB" modified="2011-04-05" version="1">MFLPKNYQLFEVDGSSLQHMPHVSHASIARPDRVRSVGKRNLPIRSKIRNHFNLRVKTVNVTRLMIHRVHREANAGKPERSLIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT2</accession>
    <name>E8WWT2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0338</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578738.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0338"/>
    <dbReference type="EnsemblBacteria" id="ADW67410">
        <property type="protein sequence ID" value="ADW67410"/>
        <property type="gene ID" value="AciX9_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0338"/>
    <dbReference type="eggNOG" id="COG2930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_4_0_0"/>
    <dbReference type="OMA" id="MKIPEQA"/>
    <dbReference type="OrthoDB" id="1808930at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233439" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="24362" checksum="8535825EB7EC8872" modified="2011-04-05" version="1">MKTKIFAGAMLLATLSATPMFASSDRSDLDDRLLQARKVIDQIASTPDKGIPDGIVSHAVCVGVIPSVKKGAFLVGAEYGQGVVSCRTGHGWSAPVFIRLAGGSFGFQIGGQATDLILVAVNDKGFQDLLKSKFKIGADASAAAGPVGRNAQAGTDIQLNAELLTYSRAKGLFAGIDLNGISISQNQDDTDLYYGTKGENFETILHGKQPVPASAKGFVGTLARYFHIARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV3</accession>
    <name>E8WWV3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0359</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578759.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0359"/>
    <dbReference type="EnsemblBacteria" id="ADW67431">
        <property type="protein sequence ID" value="ADW67431"/>
        <property type="gene ID" value="AciX9_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0359"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="VFELKHY"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="91"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="29491" checksum="8145BA8E6FFD65E7" modified="2011-04-05" version="1">MGTEAIGLSVEGELSPVLATIRRPGISTFAASLVLGAVESPVMAKAAIEPGTRNGGKLTAAQLEARALQRVEDDELIRQAQKGERTAFDSLVRRYDQSVLRLALHMLGNEQDAQDVHQEAFIKAYRHLGNFRFECSFYTWLYRIVTNLCLDQLRRRKSRREDPATVLDSSGDEMDLMANVTDDRAMANPGRELDRKVMGERIASALEKLTPRERTVFELKHYQGLKLRTIGEMLSTTEETAKNTLFRATRKLRLNLVELKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV7</accession>
    <name>E8WWV7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0363</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0363"/>
    <dbReference type="EnsemblBacteria" id="ADW67435">
        <property type="protein sequence ID" value="ADW67435"/>
        <property type="gene ID" value="AciX9_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0363"/>
    <dbReference type="eggNOG" id="ENOG5032SH4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223306_0_0_0"/>
    <dbReference type="OMA" id="HHRHLVH"/>
    <dbReference type="OrthoDB" id="1881699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="24698" checksum="E13E68CE7FE11C8D" modified="2011-04-05" version="1">MSIDEVVPVLDVHPPHEAVHGWRDFLLHLLTITIGLLIALSLEGMVEWEHHRHLVHEAEASLHAEIKSNSDGLQKMLTEVEKQQSLLKQDVVTLKGFMAKPKPKHGTMEIGFHISNFDSVSWKTAQSTGALAYMPYGKAQEFAEIYSTQDELQAAEQVAARDAIISLAPFMNSEEKDPDPDAAEANAIKDKIEVLQGQLLLVDSLVKGLDQEYKKFLAAHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX56</accession>
    <name>E8WX56_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialate O-acetylesterase</fullName>
            <ecNumber evidence="4">3.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2674</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.53" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581013.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2674"/>
    <dbReference type="EnsemblBacteria" id="ADW69698">
        <property type="protein sequence ID" value="ADW69698"/>
        <property type="gene ID" value="AciX9_2674"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2674"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015150_3_0_0"/>
    <dbReference type="OMA" id="PCEFKAC"/>
    <dbReference type="OrthoDB" id="718248at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106331">
        <property type="term" value="F:sialate 4-O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106330">
        <property type="term" value="F:sialate 9-O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230398" evidence="2">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="104"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="274"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="508" mass="55478" checksum="39CDE768DA641898" modified="2011-04-05" version="1">MKAVRVMMAGCLMFGCVAAKAELRLPKVISDHAVLQRERPIHVWGWATPGARVKAEFHAQTRYAEADALGRWSLYLQPEKAGGPYELRVSGDGGEATVRDLLVGDVWIASGQSNMEMPLQGFGPGTPIKDGEKEIAAATHPKMRLLLVEHKSSEYPLDDLSTTWTECTPETAKSFSAAAYFFGREISAKENVPVGLIDSSYGGTPADAWVSLDTLGTDASLLPAFASRATFANQQTDIRALIAEEKREDDAARAAGKPVPSHFWHPDEAPWRPAGLYNGMIAPLAPVTVKGFLWYQGEANSGYDRAPEYERLFGAMIGDWRRHFEQGNLPFLYAQISSYDSPKEYFSLVREEQRRVLEVANTGMVVTLDVGNAHNVHPADKQTVGARLALAARHVVYGQEVAYEGPLFREATTEMGKDGVKAMRVWFDAGKGLTFRGKAASGFELAGADHHFLLAEAEVEGESVVVRSQAVPLPVYVRYGWSSVVPESLYNAAGLPASTFSSEPVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX87</accession>
    <name>E8WX87_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2705</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581044.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2705"/>
    <dbReference type="EnsemblBacteria" id="ADW69729">
        <property type="protein sequence ID" value="ADW69729"/>
        <property type="gene ID" value="AciX9_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2705"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1693025_0_0_0"/>
    <dbReference type="OMA" id="SVVIEMI"/>
    <dbReference type="OrthoDB" id="2007390at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234130" evidence="9">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="16129" checksum="5B3988021F8BFD6C" modified="2011-04-05" version="1">MRTIVAILALSSASVFAQTNAPAQPSSTPALQSTLVQSAGLLAANSAASAAAAATTTTRRVSTGVTPLKLVHSVELGQTRSYSAHGFNGDRSVVIEMIVDETGKPENLKLTKVADPITNAEVLEAVSQFRYEPAKVSGVPTAVPVTLKYNITHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG4</accession>
    <name>E8WXG4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0425</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0425"/>
    <dbReference type="EnsemblBacteria" id="ADW67497">
        <property type="protein sequence ID" value="ADW67497"/>
        <property type="gene ID" value="AciX9_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0425"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1209321_0_0_0"/>
    <dbReference type="OMA" id="KRSHWIS"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="72"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="26640" checksum="70720A26E2029D7D" modified="2011-04-05" version="1">MHIHGGVSGWAMFPEPKERVMAEDVQAPVNSARTSFTPLPDAKQVGDLYVALPKGNKDGVEWAHARQTILVEPQALYELWKDETSYPLWMEHVVSVTPGEGKTSHWVIGDPEDADGKRIQFDSELTEDVPGQKIAWKSTGGEVEQSGSVEFKARKDGRGTVVTLIQGVKVGALASFAASVAKRGPKQTVIEDLRHFKQMAEAGEIPSVKGQAHGPRGMSGGIKEWMYGETNPTPPGTSEGPLTAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH4</accession>
    <name>E8WXH4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0435</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578835.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0435"/>
    <dbReference type="EnsemblBacteria" id="ADW67507">
        <property type="protein sequence ID" value="ADW67507"/>
        <property type="gene ID" value="AciX9_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0435"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="PDWNINF"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="32291" checksum="3C7EE54D88B55C33" modified="2011-04-05" version="1">MTQSISTNAKVWLITGTSSGFGRELAEQLLGAGEKVVATARKTETIADLAETHPDTALVVALDVTKEETIEAALKAALDKFGRVDVLVNNAGYGLAGAVEEATEAEFMPVFETNVFGLIRTTRAFLPQFRKQKSGSIVNLSSIGGLIGSPGWGYYNASKFAVNGFSEALAAEMALLGVHVMIVEPGPFRTEFLGSSGKEAEERIADYDETAGKTRQYFQEQSGKQPGDPVKAVKAIIDAVNAAEPPKHLVLGKLAFDRMQARLEVWKKDLAAWETTSLGADFDKADAAAGQAAYADTRQAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ3</accession>
    <name>E8WXJ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1556</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579928.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1556"/>
    <dbReference type="EnsemblBacteria" id="ADW68609">
        <property type="protein sequence ID" value="ADW68609"/>
        <property type="gene ID" value="AciX9_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1556"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_1_0"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21344" checksum="96302854C38FADA4" modified="2011-04-05" version="1">MKGLWVALGLVGAIVLVLIFGAGSYISTKNALVQKNEDVDAAYAQVNVQQQRRMDLIPNLVASVKGYVSEETTVLTNIANARAGVLGATDRASSIQANQKLDVAISPLLRLQEAYPNLKSSEQFRTLTDELAGTENRISIERRRYDQTLRDYNVYVQQFPNSFFAGFAGFHYRNEYFKGDASNAVAPKVDFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU6</accession>
    <name>E8WXU6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ordered locus">AciX9_2767</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581106.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2767"/>
    <dbReference type="EnsemblBacteria" id="ADW69791">
        <property type="protein sequence ID" value="ADW69791"/>
        <property type="gene ID" value="AciX9_2767"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2767"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_0"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="341" mass="36754" checksum="AE986E459753FF7C" modified="2011-04-05" version="1">MAKTYHDADADLSLIQAKKVAIIGYGSQGHAHALNLKDSGVDVRVGLRPGSKNAERAKNAGLVVDTVAEVSKWADVIMNLTPDQTAAKVYHAEIAPNMKPNCTLMFAHGFNIRFRTITPPAGVDVSMAAPKAPGHRVREVFTEGGGVPALVAVEQDASGTAMALALSYAKGIGCTRAGVLETTFTEETETDLFGEQAVLCGGAVALVKAGFHTLVDAGYQPELAYFECLHELKLIVDLMYRGGIEYMNHSISDTAEWGGYLAQNRIVTEDIKKNMKAILSDITDGSFAKKFIEENETGRHEFAKFRKAEADDQIEIVGKTLRAGMPFLEPVIVKDGTVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW5</accession>
    <name>E8WXW5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2787</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581125.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2787"/>
    <dbReference type="EnsemblBacteria" id="ADW69810">
        <property type="protein sequence ID" value="ADW69810"/>
        <property type="gene ID" value="AciX9_2787"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2787"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_1_0"/>
    <dbReference type="OMA" id="FEIQDGH"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7320" checksum="5CD7CF16B32835C3" modified="2011-04-05" version="1">MEQGTVKWFNDAKGFGFISRQNGEDVFVHYSAINSNGFKSLQEGQAVQFNVVKGPKGWQASDVQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY76</accession>
    <name>E8WY76_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1651</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580022.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1651"/>
    <dbReference type="EnsemblBacteria" id="ADW68703">
        <property type="protein sequence ID" value="ADW68703"/>
        <property type="gene ID" value="AciX9_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1651"/>
    <dbReference type="eggNOG" id="ENOG5032SBJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1666935_0_0_0"/>
    <dbReference type="OMA" id="AGHGMRR"/>
    <dbReference type="OrthoDB" id="1749364at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17711" checksum="BD99E1E64962055D" modified="2011-04-05" version="1">MPLDNLVSLKDDMVAFIAGHGMRRLPGYITEEVPTVLFEEENPDGWKDFVEHAKAAGSPFVTMSEVTLEKSDVAILLEQLKEHIFPISKSRGEDEEADLDDAEALIKHVGKTGYLQLGFAHQGVMFLFETSTEWYDRFQDLMEAATDLGGMVVDDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH6</accession>
    <name>E8WYH6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ordered locus">AciX9_2859</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581197.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2859"/>
    <dbReference type="EnsemblBacteria" id="ADW69882">
        <property type="protein sequence ID" value="ADW69882"/>
        <property type="gene ID" value="AciX9_2859"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2859"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_1_1_0"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="157"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="31975" checksum="E3E1DFFE6C65BB35" modified="2011-04-05" version="1">MPPPSELNIIDRIRRLAGPTTSRTLRLGIGDDCAILTPPPGHEILVTTDFSLENRHFRRDWHTPQSAGHRTLARGLSDLAAMGATPLAAFLSIALPVDYDPKWLDGYLKGLLALAKAHKVPLAGGDTAQAPGPHILADIVLLGHAPRGRSLRRSTARPGDKIYVTGPLGGSAAQLANLDFSSGPQTFPQPRLNLGQTLLRRKLATACIDLSDGLSTDLTHLCKASGVGAAIHSELIPIHPTATLTQALHGGEDYELLFTSAQKIPQSLATQIGEITDRKILLDNKTLKPQGWQHFTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI1</accession>
    <name>E8WYI1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2864</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581202.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2864"/>
    <dbReference type="EnsemblBacteria" id="ADW69887">
        <property type="protein sequence ID" value="ADW69887"/>
        <property type="gene ID" value="AciX9_2864"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2864"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_0_0"/>
    <dbReference type="OMA" id="CPGIKAR"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10477" checksum="D1CF762D6341CBF9" modified="2011-04-05" version="1">MKIHVPTPLRAYTDQKESVEVNATNVAGALHALVEAHPGLKTNLFAADGNLRSFVNVYLNDEDLRYLPQKDQTAVTDADELTIIPSIAGGCCCCCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI4</accession>
    <name>E8WYI4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate ABC transporter periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578910.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0510"/>
    <dbReference type="EnsemblBacteria" id="ADW67582">
        <property type="protein sequence ID" value="ADW67582"/>
        <property type="gene ID" value="AciX9_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0510"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OMA" id="AANIRTW"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005674983" evidence="1">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="81"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="382" mass="42088" checksum="F340D6E39B8E0526" modified="2011-04-05" version="1">MSPRILAALFALSLSLAALAQDRTGLDVQAARTAHVSGRAKKVYYTHPWDLSSLPSYKPQVQASGTIREWGSNYFAESNLNSYWETAFHKLQPDVKFDVHMHTALEAAPALATGVADLAACRLFTFSEEELYERAFNHEPLRILIATGSYDVPGWSPALAIVTNKDNPIAQLTVQQLDGIFGAARSGGYQGTTWHPEAGRPAAANIRTWGQLGLTGKWKEAPIHVYGLNLEYGMARDFQQMVFQGGDKWSESLQEYANYAGPDGTLKIAAEQLMLDLAKDPLGIGYSGAMFLNPGTKMLAIAEKPGSAYVAPSLETIQNRTYPMLLEVYFYLDRVPGRPVDPKLKEFLRFVLSREGQEAIAKDGKYLPLTAAAVQEQLKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR0</accession>
    <name>E8WYR0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1697</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580065.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1697"/>
    <dbReference type="EnsemblBacteria" id="ADW68746">
        <property type="protein sequence ID" value="ADW68746"/>
        <property type="gene ID" value="AciX9_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1697"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_2_0_0"/>
    <dbReference type="OMA" id="AFSDHPQ"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230076" evidence="8">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="135"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="41805" checksum="C5F4BF81B52B0B82" modified="2011-04-05" version="1">MRQLSSLGLAALLIAPVAGLAQAPSTTTPPATTKNPTGAPSPLPTPPATTPADDKKAAAKAKAQTDTLPSPGEDLKTNIKAGSEDDVNAIGTRNIGGRGMGNWYSTNWEIGVGKQYSMEVEKSAHLVTDPVIVEYVNRIGQNLVKNSDAKVPFTIKVIDSDEVNAFALPGGFFYVNSGLLMNCDEEAELAGVMAHEISHVVAHHAARQQTKMNYAQIASVPLIIMTQGSYTGYGIYEAAQLAIPMTFLKFSRMEEAEADYLGVQYMYKAGYDPQSFITLFEKLDALEKHKPGTLAKAFSDHPQTPDRIAASEEEIATILPAKPEYIVTTSEFDDVKSRLARLENKRKLNDKKDGNKPTLRRAGGSNNDPNQPGTTTGDDRPTLGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV6</accession>
    <name>E8WYV6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1744</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580111.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1744"/>
    <dbReference type="EnsemblBacteria" id="ADW68792">
        <property type="protein sequence ID" value="ADW68792"/>
        <property type="gene ID" value="AciX9_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1744"/>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="EIHEHEI"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46749" checksum="81C574DB1D296B36" modified="2011-04-05" version="1">MALLQVRESTSGMKDPLTEEACWALLNRVVASPRLQRAARLRDFLLYVGRRSLQEGSEQIHEQEIGSEVFGRQASYDTSVDNIVRVNATELRKRIEAYFEGEGLDEPILMEIPRGSYRPVFRHRFVEPQTGAAVPVMPAEIVAVSPVPDLETASVDGAASVPARRWVHWIGPCLAAVLMVGCVGLWLQNVALTRSAQPWRASPALSSFWSEVFETNPSTDVIVGDTSLALIEDITKKPISLSDYLNRRYVSQIKSEGMSQDRRDDLSLVASRDLGSPGDFRVAQRITSLDPLGHNIRVHYALEYMPALLKRNNVVLIGSRKSNPWVDLFSNSLNFSVEYDSERGVSYVKNRQPAAGEQATYISPPAPASSGYSVIAYLPGSGPNGKVIILAGTDGEATEGAGEFLTSEEQMDRFRKLLNVSKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ32</accession>
    <name>E8WZ32_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2924"/>
    <dbReference type="EnsemblBacteria" id="ADW69947">
        <property type="protein sequence ID" value="ADW69947"/>
        <property type="gene ID" value="AciX9_2924"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2924"/>
    <dbReference type="eggNOG" id="ENOG5033FHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209245_0_0_0"/>
    <dbReference type="OMA" id="PKEMIRY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="57" mass="6410" checksum="EA1BE5AB9A3DAA6A" modified="2011-04-05" version="1">MLSHFSSVLLFSLFTSVVFGITQRAQPRMMLRFGAFCMLLFVGGTIAASWVMYLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ61</accession>
    <name>E8WZ61_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase domain protein FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578991.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0592"/>
    <dbReference type="EnsemblBacteria" id="ADW67663">
        <property type="protein sequence ID" value="ADW67663"/>
        <property type="gene ID" value="AciX9_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0592"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803547_0_0_0"/>
    <dbReference type="OrthoDB" id="1073652at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="168"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="37317" checksum="9583E53CE8E8B761" modified="2011-04-05" version="1">MPIDKKLRRLLRDLLFGGPILPQEFTIGLKDPAAEIAVWLEGMGAPLDVSSRLSTACSSPFLICLSFEESLLPDSAQRSHLSLHFREREGDQSLLGRIDLRFISRFKVSDLHLLLFEARAAANYCLSARIIWPQYLFQTYARWRKPNTSGMSMTFLEQRAAMVTFIRPHPIMLVSAADRSGGNLFPMNIMGELGSGRIAFALKTSRTAAPLIQRTGRAVLSNVPFTQASTVYRLAPQHFAVSIDWTQLPFGTNPSRILGVPVPVFALRVREVQIEHVQPLGSHTLFIARILSDETPAEGETLCAVHGFYQARRLKTSAPALHESLLDDRRNKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ83</accession>
    <name>E8WZ83_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0614</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579013.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0614"/>
    <dbReference type="EnsemblBacteria" id="ADW67685">
        <property type="protein sequence ID" value="ADW67685"/>
        <property type="gene ID" value="AciX9_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0614"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_1_0"/>
    <dbReference type="OMA" id="QMGHNDA"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234188" evidence="1">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="62"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="31774" checksum="1E0CC658AFB1948E" modified="2011-04-05" version="1">MRLRSGILALLFLSVFVTAGLAQAPGEKPGDPVAPFTTDPTLNARLNLPVPKNPGLPTLFLVGDSTVRNGKGDGANNQMGWGEPLVAYFDLTKINVVNRAIGGRSSRTYITEGHWADVLAMMKPGDVVLFQFGHNDSGPLDDTARARGTINGVGDESKEIENPILKRHETVHTYGWYMAEYVTETLAKGATPIVCSLIPRKTWKDGKIVRSGGDSYGGWAKHVAEAKHVGFIDLNSIIADRYDAMGEAAVEPLFGDPHTHTTLAGAQINAEAVVKGLKALPNDPVGKDFSAMGMAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG1</accession>
    <name>E8WZG1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1801</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1801"/>
    <dbReference type="EnsemblBacteria" id="ADW68849">
        <property type="protein sequence ID" value="ADW68849"/>
        <property type="gene ID" value="AciX9_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1801"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029930_1_0_0"/>
    <dbReference type="OMA" id="DYAHTIY"/>
    <dbReference type="OrthoDB" id="1626384at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="466" mass="51852" checksum="970B2FE9804137DD" modified="2011-04-05" version="1">MRAGWAEARPWQTNVALGLIGLGMIAVARQLVVEEDHYVLGHAAVSCVHLGLYLAALLVVWLRPANVDRWTFGVILVVAVACRLVVLFPPPVGSTDVYRYAWDGVVQHAHINPYRYVASDPALAALREPNQDLYDSMNRRDYAHTIYPPVAQVLFYLITWISPTVTAMKTAMMLFEGLTLWGLVLMLREMGLRREQAIVYAWCPLVMWELAGAGHLDATAMAFIVLAFLFRYKEKPGWVGVFLGLAFLTKFYPIVLFPALYRRGDWKMPAVIVGMTVGFYAMYLSVGKMVFGFAGTYVQEEGMESGTRYFLLSLVQHVPGLHGTPNGVFLGFAAVVMLGVTVWAWVVATPKDAKPMAFLRPAFGAAMALMLLFSPHYPWYVAWLVPFLCLMPNLPVLAYVGGLFYLCTTAMAVGYGPKQYLLNEYLYGTVVAAVIIEVILRQTPWTRGWFLPSTDDLPVLSSAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG3</accession>
    <name>E8WZG3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1803</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580170.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1803"/>
    <dbReference type="EnsemblBacteria" id="ADW68851">
        <property type="protein sequence ID" value="ADW68851"/>
        <property type="gene ID" value="AciX9_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1803"/>
    <dbReference type="HOGENOM" id="CLU_2464705_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9590" checksum="03D98D7F14824D39" modified="2011-04-05" version="1">MSIDTLTVKLLSSVLKSETRKKLFTMVAGRRIADMDQLKEATSGSDIRSDLEALENADLIGAGQASEKYYVTARGLKVARDLQELSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH0</accession>
    <name>E8WZH0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein serine/threonine phosphatase with GAF(S) sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1810</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580177.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1810"/>
    <dbReference type="EnsemblBacteria" id="ADW68858">
        <property type="protein sequence ID" value="ADW68858"/>
        <property type="gene ID" value="AciX9_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1810"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_6_0"/>
    <dbReference type="OMA" id="RYGSARM"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="62"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="225"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="448"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="661" mass="73673" checksum="08A67CAD57324177" modified="2011-04-05" version="1">MAPPKKPATLPASTQSPESLEGDYAPSRPLFHTHAPEPNIRVEPLQLDFLLRLADALNTTLDLNTLMHRVADLVRAVIDYRIFAILLINDRTHELWMRFQTGHTTEIERMRIKLGRGVVGQAALQRKSILVEDVTKLENYINANPHVLSELAVPLIVKNKVIGVLDLQSEAPAFFTPDHQRLLELTASRMAVAVENARLYTRVSRQAQTLTVLHEISHEITSILDPDDLLERIGALLKRVIDFQMFTILLWNDKSEQLEHRFSTRYGERVIRQRTVLLGQGIIGTAAQQRTPILSPDVRKDSRYFAENPETRSELSVPLIYKGKVIGVIDLEHTRVNYYNEDHQRTLTTLASQIAISIANARLYQRISEEEQRMERDLNMAREVQLRLMPAAPPQPANAEIATSFNAARSIGGDVYDFLDYGPAPNPDLEDPDAPPTRTTVNPSPETTVDLSFPGYPTRTVIALGDVSGKAAPAALYAALVSGLMRSLAPRRLPPAQLLSLLNAQLQERKLDSQYVTMLMSLWDDRTRTLRVANAGSVQPMLITRATPTSTPESLTNALEVTTIPVEGFPLGLFPIATYDETLLQLAPGDFVLFFSDGIVDAENSRGEQFGSERLSTLLQHHPTATQSAKHMVAAILEAVATHQSGTEHFDDETLIVLHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL2</accession>
    <name>E8WZL2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2963</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69986">
        <property type="protein sequence ID" value="ADW69986"/>
        <property type="gene ID" value="AciX9_2963"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2963"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356266_0_0_0"/>
    <dbReference type="OMA" id="YVPNSMV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="783" mass="79484" checksum="F326EC025C129896" modified="2011-04-05" version="1">MRRLVSLAVLLLFAIPFGVSVSGCSKKTVVTYCDGNDSGPVIGQVTTIDLEPRLTGISLNESQIGSVSGATAKDCKSSSVSVTAFTYGSSNLNLVDIEPTNGRLCAGVWNRNTGGGVPDFTTCTGNGGSGIATITASAQGAVSNSIPVFVHPVVTSIVLGAPSVNCTTDPASNCINTNVAATCITGVPTAVAAYTGNACFSQGSAGQLTARTYQGTDITNPANNISCQVGPLTFSAQNTAVVTIDPNGLATAQAPGSTIINANISNSSSTAGFFATCPPASIVLTPAGSTTVPTAPITVAQNIQQDLVATVTDTNGVKINNVALEYESTTPITVPVAGGIVTPTYNGAASVTAVCQPPTCNSSPIQQIGLFGNGSAVTSNPVRINATGTGNSTVLYVASTNSQFIQAYDFTAALQNAPVRLPYAPNSLVLSTDLSTIYMGTPNEIMTFSTATNQLLKEDTTISGTVISVSPDSGTAVITDPVRKLVYLYTSAGAISTEYGGVATRAQWTPDSQTVYITTNDSRLLVYSTFNGWTAKNISPVASDVAITIPQQGAYLAGATTEAVSACPVGTVSGAVGSQIVTNTYYPQSDADAATTDLLTATTDGKHMIGATSAATPRLTDFTITLPSTTTTAGQVVPAACPQPGASAQVFTHSTKSLAFTTAVPTAITGVIPTTDSTYALFTYTGTGAVVPQYVPGTSTLTNIALQKTTAVAPIAPVAGVISTDNQTAYIGTTGDNLVHQLTRNTTGFSDTVAPLNPALPAITGSGIATPNLLVQRPRKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL5</accession>
    <name>E8WZL5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581303.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2966"/>
    <dbReference type="EnsemblBacteria" id="ADW69989">
        <property type="protein sequence ID" value="ADW69989"/>
        <property type="gene ID" value="AciX9_2966"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2966"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_0"/>
    <dbReference type="OMA" id="AMEMIMT"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="26957" checksum="B233FF4D7450F3C1" modified="2011-04-05" version="1">MPYETLLLEVEEAIATITLNRPQVLNALNAQLFTDLDAAITTLSSNAEIRAIILTGAGEKAFAAGADISELAQTDATTGETLALRGQAVFTHIETCGKPVIAAINGFALGGGCELALACTLRLASETARIGQPEVKLGLLPGYGGSQRLPRLIGPSAALKLLLTGDMIPAPEALRLGLVDDIHPPANLLPAALALAKKIAAQAPLAVQACLEAVHQGADLPLNKALALEAHLFGRLSATEDKKEGTAAFLAKRPPTWTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ9</accession>
    <name>E8WZQ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_3012</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581347.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3012"/>
    <dbReference type="EnsemblBacteria" id="ADW70033">
        <property type="protein sequence ID" value="ADW70033"/>
        <property type="gene ID" value="AciX9_3012"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3012"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_6_2_0"/>
    <dbReference type="OMA" id="IMSVLFK"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="532"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="549"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="884" mass="96608" checksum="42A44AD4F77F45CE" modified="2011-04-05" version="1">MKPLRLVSAPTRSRRLNEILGMIVLVAAGLFLLALASYTPTDPSFNSVGGYITGRPAHNWIGLFGAWTSDAILQTLGIAAFLLPVLLVRLGVCWLKSRPAGSAIARWLGLGMWVVFAPAAVALLPGHLLWRNSLPIEGLGGRMVSDFTIQLLNLPGACIVLALAVLLSLYLATTFSFSTAREWMTMHFAFAASIRERWNQRQARRRGEMPDVDLVDATGEVYGAKREKLAAEARKERERAEKAATRSSNTLLSTLFGWWPRRKDATISITPSQPEAAPTSVWEAMPRMNVDAPPVTPLSTATAAAAPYAEALAAAAAPLPLQPDELDLAPVQGRFVEEEPFSFLSQPVARPVQEPKRAVLKPQLVEAVTAEAGPISFGRRADTDVKAVAITAKSVRGYKLPSSSLLYRSEEQAIVREDALREEARVLVEKCGEFGVDGQVTQINPGPVVTTFEFRPDAGVKYSRVTGLADDLCLAMAAESILIERMAGKSTVGIQVPNSDRETIWLRDVVECESFAQSKSKLAIALGKDINGRIVTADLASMPHVLIAGSTGSGKSVAINAMIMSVLFKSTPEQVRMILVDPKRVELGMYEGIPHLFTPIITEAKLAANALRNAVREMERRLKLLAANHVRNIDQFNKLFDNGSEYLFEDVNQEPLPYIIIIIDELADLMMLDRSNVEESITRLAQMARAVGIHLILATQRPSVDVITGLIKANVPTRMSFRLATKVDSRTIIDSNGAESLLGRGDMLYLPPGTSRLQRVHAPFVTEKEISAVTAFWRAQGEAEYVEGFLEGPKDEKDGSGVEGSHSDENENDPMFDDAVRLVFEFGKASTSLLQRRLRIGYGRAAHLIDLMERDGLVGPADGSKPREILKSPSFYSEIDAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR5</accession>
    <name>E8WZR5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579054.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0655"/>
    <dbReference type="EnsemblBacteria" id="ADW67726">
        <property type="protein sequence ID" value="ADW67726"/>
        <property type="gene ID" value="AciX9_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0655"/>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920589_0_0_0"/>
    <dbReference type="OrthoDB" id="1546987at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234017" evidence="1">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26188" checksum="2C37D57E98F5B736" modified="2011-04-05" version="1">MYRSLGFFLAVATLSAQAQYPDPASLSSSPAPIVRDNPRALSQPQLFDTQPNAGVSVRSDVADGVQTVASSANATELRIVQGRADITVHHPTDHSEILIDLPGGQVALLKDGLYTFNAKTNTVRVLHGEAEVGGVNGEKGVKVKETQQLSFFNNFKPKAVNAYDYELTADLLQEGGPRGDGPGYGYDDGFYGGSPYDGGFYPYGGFYPYGYGYPIGIGLGFGYGGGFYRGGYGGFHGGGFRGGGFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR9</accession>
    <name>E8WZR9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ordered locus">AciX9_0659</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579058.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0659"/>
    <dbReference type="EnsemblBacteria" id="ADW67730">
        <property type="protein sequence ID" value="ADW67730"/>
        <property type="gene ID" value="AciX9_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0659"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_0"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="6">
        <location>
            <begin position="62"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="358" mass="40403" checksum="59440C61FFD1B0DF" modified="2011-04-05" version="1">MFDRLAQMEVRYDSLSRDMSDPVLVNDQKKFQAIAKEHRLMEPIVEKYRQYRKVADGIAEAKAMLSESDPDLKEMAKEELASLEPQLEPIAEALKVMLLPKDPNDDKNIVIELRAGTGGDEAALFVAEMFRVYLRLAEQHRWKVQVLSESFSGIGNGLKDVTAIFEGDRVYSQMKYESGVHRVQRVPATETQGRVHTSAITVAVLPEAEEVDIKIEAKDLRVDTFCSSGPGGQSVNTTYSAIRITHLPTNTVVSCQDEKSQIKNREKAMRVLRSRLYEVAEETRHQAEAKIRKDQVGTGDRSEKIRTYNFPQNRLTDHRIGLTNHNLNMVMEGQLQPTIDALIAHDIAEKMKGEPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT1</accession>
    <name>E8WZT1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579070.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0672"/>
    <dbReference type="EnsemblBacteria" id="ADW67742">
        <property type="protein sequence ID" value="ADW67742"/>
        <property type="gene ID" value="AciX9_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0672"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_0"/>
    <dbReference type="OMA" id="DTRHFDY"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="319"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="43206" checksum="222E7BC15DC2E73F" modified="2011-04-05" version="1">MKLRPVLLVLLLLAGFYYLTTRGASSRALIPWAHGVSRASFVPAAGEGSVDRSVGSDDGPLGNFHLTESASAAPAFDAEEQQNIAVYRKALPSVVNITSTAVSYDFFNRPVPQQGQGSGFVLDKEGHILTNNHVIDNAQRVEVTLSDKHKYKATVIGIDTHHDLALLSITAPGLVPATLSDSGGLVVGQKVYAIGNPFGLSGTMTRGMISAIRSIGTSGTQGGGGAIEDAIQTDAAINPGNSGGPLLNSRGEVIGITTLIASSGADQSAGIGFAIPINTAKAVLDDFAHYGKVRRPSLDIETLPIGPDIAEQIGLPADYGVLVEKTMPGGAAEKAGLRGGNQRVYMGNTPIDLGGDLIVGMDGQEVQTPQDLSQALTRHKAGDVVTVTVFRGQRKLNLKVTLGDAKDAISLPGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT7</accession>
    <name>E8WZT7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="8">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="8">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabZ</name>
        <name evidence="9" type="ordered locus">AciX9_0678</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579076.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0678"/>
    <dbReference type="EnsemblBacteria" id="ADW67748">
        <property type="protein sequence ID" value="ADW67748"/>
        <property type="gene ID" value="AciX9_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0678"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_2_0"/>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19562" checksum="4D6FDCBB68A65E87" modified="2011-04-05" version="1">MSETETAPTATETATPPAYKQTMDITEIMAILPHRYPFLLIDRVIEIERKQRIVAIKNVTVNEPHFTGHFPDYPIMPGVLMVEAIAQTGGALLLTEIEDRDQKLMVFTGIESARFRRPVTPGDQLRIEVKVVNWRTRVVKMAGVITVDGKVVCDATVTCALTDRPKKAAAASAESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ7</accession>
    <name>E8WZZ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580212.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1847"/>
    <dbReference type="EnsemblBacteria" id="ADW68893">
        <property type="protein sequence ID" value="ADW68893"/>
        <property type="gene ID" value="AciX9_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1847"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_24_1_0"/>
    <dbReference type="OMA" id="DFINWAF"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="56"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="45844" checksum="81E5B685B4D5E094" modified="2011-04-05" version="1">MITRRMFNQGLTAAALYSSTSATMTGSALGAEVQASERAEAEAAKQIAPAKASTPFRMGIIGAGSRGQELIRSFLRVPGVSVVAAADVYPLRFQQLSRVCTNDVAHYDDYRKLLERKDLDAVIVATPLGLHGEHVLAALKSGHNVYGEKVMAYTVEQAQAIVSAAGEQKVIYQVGHQYRYSPWIRAAVARVQQGEIGEVTHIAGYWHRNNDWRRPVPESSLERLINWRLYHQWSLGLIAELGSHHIDIANWVFGANPEAAMASGSICRYHDGRETDDNVQMVLSYSGGRRFIFSSVTDNAKMGDQLWLYGSKGSLNLTLEDASFFYEPKKITRAVPVGNGKDALVTSASYAPSSEMPYRGAGKPVDVMTAEDPTTAATRAFVYCVRTGTKPISDARVGLGSAMAVIRANESLRGRAEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X015</accession>
    <name>E8X015_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase hexapeptide domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1865</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580230.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1865"/>
    <dbReference type="EnsemblBacteria" id="ADW68911">
        <property type="protein sequence ID" value="ADW68911"/>
        <property type="gene ID" value="AciX9_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1865"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_7_1_0"/>
    <dbReference type="OMA" id="NHGCSLD"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="20600" checksum="EF22B1236AF3D48B" modified="2011-04-05" version="1">MSSPFKSLLVAPLRGLLRVSAGVRESVRRIYSHAALAAQLKQALPASVVVLGRVLVYGTGEIRFGQDTLLYPDLHLETQGGARLNLGDGVVISRGVHLVAMAGITIGAGSMIGEYASLRDANHARKDGVAIRDAGHTARPITLGKEVWVGRGAAILAGVTIGDHATIGANAVVTRDVPAGAVVGGVPAVALRQRQALPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X043</accession>
    <name>E8X043_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580258.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1893"/>
    <dbReference type="EnsemblBacteria" id="ADW68939">
        <property type="protein sequence ID" value="ADW68939"/>
        <property type="gene ID" value="AciX9_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1893"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_0_0_0"/>
    <dbReference type="OMA" id="QHWTRRT"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="85"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="37233" checksum="AA25CCF7CC8A82BD" modified="2011-04-05" version="1">MRTLERAKKSGKKFENVVPTSVGDLSLMLKLLPMYVTNKAETEPKGGLGPFRTDAQVYGAEPESGLRVTWFGHSSTLVEIDGVKLLTDPVWDLRAAPVQWFGPKRFFAPTIPLEELPAIDAVVISHDHYDHLGAGTVKALAAMRPEMRWITSLGVGADLRKFGVRADRITELDWTESLVVKGVNGAEATVTSVPSRHFSGRSLTNRFETLWAAFVFGGAKHRVYYGADSGEWDGFPAIQKAYGPFDLTMLEVGAFNELWKTIHLGSEGAVKAFEELGGGVLMPIHWGLFNLALHGWREPIEEVTKLADEQGITLFSPGPGEPTEFVAGQEVRSGWWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X091</accession>
    <name>E8X091_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3052</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581386.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3052"/>
    <dbReference type="EnsemblBacteria" id="ADW70072">
        <property type="protein sequence ID" value="ADW70072"/>
        <property type="gene ID" value="AciX9_3052"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3052"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13153" checksum="FAFD1615CF71E479" modified="2011-04-05" version="1">MKILIVDDELVVARTLSLIFEKHGFEVTTAYSAGEALIAAMSQVPDLVICDIDMPGRDGVDLMLDLGRELPGCPILVLTGLYGSLGRVQDTAKGLRQKVQILTKPCQPAELLREAGTMLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D5</accession>
    <name>E8X0D5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF374 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0729</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579125.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0729"/>
    <dbReference type="EnsemblBacteria" id="ADW67799">
        <property type="protein sequence ID" value="ADW67799"/>
        <property type="gene ID" value="AciX9_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0729"/>
    <dbReference type="eggNOG" id="COG2121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086327_1_0_0"/>
    <dbReference type="OMA" id="PAMFIGH"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07983">
        <property type="entry name" value="LPLAT_DUF374-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007172">
        <property type="entry name" value="DUF374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04028">
        <property type="entry name" value="DUF374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF374" evidence="1">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="23846" checksum="E5B903C7D574E2BF" modified="2011-04-05" version="1">MSYSRSQRVVLAVAPFVAAWVIRALGATLRYEDVAAPGVPPGGTIPGAKVYAFWHRSLLACAYYFRGQKIAILISRSFDGEIIARTVERLGFIAIRGSSTRGGSTALRQMVEHFKNGHQCAITADGPKGPPMIAKPGIVQVAELVDASYIGAFYALPKRAWVLKTWDSFVIPKPFSRVALTWPPLVMRSGEETLEELQVGVQAAMDEAVRLAEAWKAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D9</accession>
    <name>E8X0D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0733</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579129.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0733"/>
    <dbReference type="EnsemblBacteria" id="ADW67803">
        <property type="protein sequence ID" value="ADW67803"/>
        <property type="gene ID" value="AciX9_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0733"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_5_1_0"/>
    <dbReference type="OMA" id="KSDKMAP"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230130" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="10605" checksum="5F3F5E58DADB571C" modified="2011-04-05" version="1">MRFFRHTLAAAVFLLTPLMFSQAKPATPAAAAAASADKLDINTATLGQLKALPGIGDAYAARIVKGRPYAMKTQLTQKGIIPDATYSKIKDMIIAKQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I1</accession>
    <name>E8X0I1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpS</name>
        <name evidence="10" type="ordered locus">AciX9_0776</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579171.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0776"/>
    <dbReference type="EnsemblBacteria" id="ADW67845">
        <property type="protein sequence ID" value="ADW67845"/>
        <property type="gene ID" value="AciX9_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0776"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_0_2_0"/>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="13641" checksum="A01F83B030EE120C" modified="2011-04-05" version="1">MVMGIGTDLTEIGRVERSIARFGERFLERVFTAGEQAYCLRKKGSGESFAARFAAKEAGAKALGTGISRGVSWKEFEVRREPGQRPTLHLSGRAAELAKAMGVVRISLSLTHSRELAMAVVIMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R3</accession>
    <name>E8X0R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1968</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580333.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1968"/>
    <dbReference type="EnsemblBacteria" id="ADW69014">
        <property type="protein sequence ID" value="ADW69014"/>
        <property type="gene ID" value="AciX9_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1968"/>
    <dbReference type="eggNOG" id="ENOG502ZP96">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2142376_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="13163" checksum="E130CA5B8E3D7F04" modified="2011-04-05" version="1">MSWWVTATLELGLSSEQFYDLTPRQFQALCKRYQNNRETVRNHTELMFGQLTSWVVNTGFRSYFEKFQIPAHFMPSLLALKQAPTKQPNTRMTKAKRAAVVDTIRMMFPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W4</accession>
    <name>E8X1W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized conserved protein UCP016719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2081</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2081"/>
    <dbReference type="EnsemblBacteria" id="ADW69125">
        <property type="protein sequence ID" value="ADW69125"/>
        <property type="gene ID" value="AciX9_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2081"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257385_0_0_0"/>
    <dbReference type="OMA" id="GMAAVIW"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="8">
        <location>
            <begin position="588"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1510" mass="161567" checksum="A1F23C6B48CDE094" modified="2011-04-05" version="1">MTPSLTPLLLTIPTLGTTRLSPFDLALVALYLVAITIFGLRFSKRDKTSKDKSLKSYFLANNTIPWWAIALSIVSAETSTLTIVSIPGVAFAGDFGFLQIVLGYMLGRIVVAALFLPKYFQGEMLTAYQLIDRRFGAGLHKVTASLFLLTRAAAEGVRVFAISIVVGLAIGTGDVLSIAIISALTLLYTFEGGMAAVIWTDVVQMALYVAGTIVAIFTLGAHVPGGWSHIHAVAGAAGKFHMLDFSLTLTRSYTFWAGILGGTFLTMASHGTDQLMVQRMLAARNLRESRLALLSSGAVIFLQFTLFLLIGAGLYVFYGNHPQSFKSNDHIFPTFIVREMPHGVAGLLIAAILAAAMSNLSAALNSLASTTVIDFYVPFKSRTSSPKKAVVILSEAQNLSISPEPAPSSTDTTLISRLATILWAIVLFAIAVYSVHAGGKGHVVETGLSIASVAYGCLLGVFLLGTLTKYATELGATLGMICGFALNLFLYQATFPHPFIPLPIRIAFTWYVLIGSLATFALGSLFSLIPRPKPPTLTTAAILLIFTIASSAQPTHAVILRAAENLSSSLVAAQAPPSIPYDFTSASTLIQTAIADHKLPGAVLFIGHNGKIVFHHAYGNRKLAGEPGLDGKPSPAEPMTEDTIFDIASLSKVLSTTTAILQLYEAGKLDLDAPVVKYLPTFAQNGKQSITIHQLLTHYSGLPEDVNLKDSWGLAAPDKAEGISRAMASIPYGPPGVTFKYSDINFITLGAIVEKLSGEPLNEYARLHIFTPLGMVSTNYHPFDKACGPAQRSGAAIEYLPKLPKAFECVGPAYWTPIYSIPSTAPTAHDDESKLDPTANPDFDHLLRGTVHDPTTRRMGGVAGHAGVFSTASDAAKFCQALLDKLVNNTGPFPLKQSTLKLATSPQAPATAVDTATIFLPNGTTTKGVAQRGLGWDLNTAFSRPRGEIFPITTKEHPGSFGHTGFTGTSLWLDPTSNTYVILLANAIHPRGGAPISALRGQVATAAARALGLTPQGGVSSEARPPSSSPSLKPVLYEPGAPRPASGTWVPTTAPKVLTGIDVLEASNFLPLRKLATQHQNHLRIALLSNQTSQDSSGHRTIDILLHADPSIELTTLFAPEHGIAAALDQENLGKQTDPTTNLPVISLYGPKPADKRPKSSDLENLDAVIIDLQDAGVPFWTYETIVGYFVEATANTHTTLIILDRPNPVGGLAVQGEISDRQTNVYTNYTPIPVRHGLTIGELAQYFRSLLPHLPGDQSQTGIHATDRGNRQTSIAQPSNTQTGIHATHTPPRIFNETTGELSPANPPNELPASPTDNLLVIPMQNWTRAQFFDQTGLTWIPPSPNLRSPTAATLYPGIGLTEQTNISVGRGTPTPFENLGAPWLNPKELIAYLVARKIPGIRFTPTTMTIAEDANKYPSHGQTIPAIHFEVTDRTILDTPELGLELLSALHHLYPTQFNLARAKTLLASAQTLADLTAGKDPRDITAAFQPALSQFRTATAPYLLYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X2</accession>
    <name>E8X1X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite and sulphite reductase 4Fe-4S region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2089</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580449.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2089"/>
    <dbReference type="EnsemblBacteria" id="ADW69133">
        <property type="protein sequence ID" value="ADW69133"/>
        <property type="gene ID" value="AciX9_2089"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2089"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_2_3_0"/>
    <dbReference type="OMA" id="MGMTHGD"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="158"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="419"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="582" mass="63572" checksum="836B1A7D360C9224" modified="2011-04-05" version="1">MPDEVLTAPAAEAKPKEVKETKAQKSERLKLAKNPWDAWDEVREYAKGGRDSVAPEWSNLYFKWWGVYTQGDGLGVTGGANGEGKASEFFMMRIGLPNGILTSLQLRVIGNLTKKYARNLSDITTRQNIQLHWLTIGALVEVVDALTEIGLSPKGACGDVVRNVTGCPLAGIDGHQLLDASPLALELAHKLTANPEFYNLPRKFKISATGCPLWCSYPEINDVAFTAITREINGATEIGYTLRVGGGLSTEPHIAVRIPAFIPQDKAYDVCVAVVRIFKEQSELRENRTRARIKYLFMRHGWTAESMLEAIEQQLGYKLDPSPLTADPVPDDVYRDHIGITPQKQSGLSAVGASVMGGRLSGDQLIQLADLAEKYGDGSLRATIMQNILLVNIKNENVRALIADLAALDLRVEVSPFWRGAVACTGTEFCKLAISETKAFSKWLTEEMEGRLPGFDQQIKLHVTGCTNSCGQSWIADIGLEGKKIKKDGKLVDAFYFCVGGAVGKYARAARQIGYRAAAEDTPEAVERLLRGYLALRTPGEDLRAYFARTSDEDLRTHLAGAVVTPVERDAPPAGGRHAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X205</accession>
    <name>E8X205_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2122</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580482.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2122"/>
    <dbReference type="EnsemblBacteria" id="ADW69166">
        <property type="protein sequence ID" value="ADW69166"/>
        <property type="gene ID" value="AciX9_2122"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2122"/>
    <dbReference type="eggNOG" id="ENOG5032T87">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149246_0_0_0"/>
    <dbReference type="OrthoDB" id="2047977at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045385">
        <property type="entry name" value="DUF6526"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20136">
        <property type="entry name" value="DUF6526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="146" mass="16779" checksum="3BC0D774ECC8EF8D" modified="2011-04-05" version="1">MAAEQSFKSHTALDPITHFTLLPLGLIALGLSLYLIRHDWPLHRLDHLWMILASMGLILLNLKSRMYPLAVQDRVIRLEGRLRLHELMPEEHHSIADQLTTRQFVALRFACDAELPALARKAVAENLDGKTIKQNIGTWRPDYNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X294</accession>
    <name>E8X294_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579350.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68026">
        <property type="protein sequence ID" value="ADW68026"/>
        <property type="gene ID" value="AciX9_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0959"/>
    <dbReference type="HOGENOM" id="CLU_2329811_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10275" checksum="AD2C3186766A0614" modified="2011-04-05" version="1">MPFDGGLKPTSNPNGNGNGSGNGNSNSNSNGNCNCNCNCNCNCNGKSKSNNNGKSRSDSNGKSGGNSKNKQQQQQLRRFFASLRMTVGEEVRLVGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A3</accession>
    <name>E8X2A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphohistidine phosphatase, SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0968</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579359.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0968"/>
    <dbReference type="EnsemblBacteria" id="ADW68035">
        <property type="protein sequence ID" value="ADW68035"/>
        <property type="gene ID" value="AciX9_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0968"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_3_1_0"/>
    <dbReference type="OMA" id="SQMFWLT"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20305" checksum="021E2D93EEF674C4" modified="2011-04-05" version="1">MNLFILRHASAGTKRVNPLLDLKRPLDKEGKQHCLQLAHTLNALKINFDLVVSSPLKRALQTAQLVATETGYEAKILLSNGLAPEATVADFERLLTECRGRENLLLVGHNPNLQQFLSSLLVRQAAQPAPGQETAPKIRLRKGSLARLSITRGPATLQSLLDPRTIRALYATSTKSSRRKTSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G8</accession>
    <name>E8X2G8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="17" type="ordered locus">AciX9_2148</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580508.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2148"/>
    <dbReference type="EnsemblBacteria" id="ADW69192">
        <property type="protein sequence ID" value="ADW69192"/>
        <property type="gene ID" value="AciX9_2148"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2148"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_0"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="261"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="396"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW69192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="474" mass="49429" checksum="1E89E4E7192BB4FC" modified="2011-04-05" version="1">MRDGFAIAIMAAGKGTRLKSKRPKVLHEIGGKALLLHVIAAAKTVVPASEILCIVGHEAERVKAAVAATGVQFVLQAEQRGTGHAIQMVKAWFAETGVAVPENLLVLSGDVPLIRPETIDAICDVHLREGAAMTILTAVPPNPTGYGRVIRVSETGPEVTAIVEQKSLTADQMGAQEINSGIYCFRTAALFGKLDSLSTNNAHGEFYLTDVAAMLVADGERVVAVKAESVDEVLGANTIAEMMHLDQAMRMETAKKLMAMGVTIFRPDTCVIDAGVTVGADTVIEPYVQLLGETRIGVECRVRSYAVVQNSTLGDGVLVRNGCVLDGAEVSDGAVLGPYAHLRPESRIGEGAHVGNFVETKKMTLGKGSKANHLNYLGDAVIGAGVNIGAGAITCNYDGVNKHLTTIGDGVFVGSDSTLVAPVTLGDGAYVAAGSCVTHDVPAGALALGRSRQVNKDGWAARKKAAQEAAKKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H7</accession>
    <name>E8X2H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase caa3-type, assembly factor CtaG-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2157</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2157"/>
    <dbReference type="EnsemblBacteria" id="ADW69201">
        <property type="protein sequence ID" value="ADW69201"/>
        <property type="gene ID" value="AciX9_2157"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2157"/>
    <dbReference type="eggNOG" id="COG3336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054944_0_1_0"/>
    <dbReference type="OMA" id="GMPFHAF"/>
    <dbReference type="OrthoDB" id="1553593at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="299" mass="33600" checksum="17F553B636D7A632" modified="2011-04-05" version="1">MISAVLITSPDLIGDWTPPLFLTATCILTIALYLRGFSLLRRTRPTFSSLRAASFCAGILVLWLALASPLEELADTVLTAHMIEHLLLMSAVPPLVLIGWPVVPMLRGLPLWLRRSLVHPLLRSRLIRAVLHWLDSPLVAWLLMNATLLLWHLPKAYDFALEHEGWHDFEHICFLATSLGFWWILLRPWPATARSASWGFLAYLLSADFVNTGLSATLAFIGHPVYAYYLNHTNPLGMDPLMDQQVGASIMWVFGSMAFLLPALVLAARMLSGGSRDERKSSQLYEREPARIVRDLKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T0</accession>
    <name>E8X2T0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ABC, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3369</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3369"/>
    <dbReference type="EnsemblBacteria" id="ADW70377">
        <property type="protein sequence ID" value="ADW70377"/>
        <property type="gene ID" value="AciX9_3369"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3369"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613830_0_0_0"/>
    <dbReference type="OMA" id="NVEHKRD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="484" mass="53644" checksum="86DAD0FC5BF87422" modified="2011-04-05" version="1">MLEPSKTTISKVSSAFQFAHHLPFTPTQATEILRQIPTLPGVFALRGERDTDEPYLTRAADLRRRMTRLLAPPESQSRRLNLSQKVTTIAWCVTGSEFESTLVLYDALAAQFGHPEARRRMKLHTPTFLRFTAEHAHPRVYSTNKLSRRSLDNTYGPFQSRTAAERYCDAVLDLFKLRRCHEDLEVSPSHPGCAYGEMKKCMAPCNQTCTADEYAAESAAVKAFFDTHGDSMLAAISADRERASSDMEFEQAAALHTQYTKVKATAALADELVRPIPHLRAVIVQKSSDTAEDPNQAALFMLEAGCLSGPERLSTLGVRAVKEQTSVGSSLFAQPLMLQAVPLEPEAAATPTDSPELRAEQVLQTLTDKFIQAGPPDPARLSDHLSLLRRWYYRPEKQRQGEVFLPNPDGSWPIRRILRGAARMALGDPRPIAETNREAAPEAAEAIKTKLLHEGREGIERAVPVIAGRARRKKSVVPADVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T2</accession>
    <name>E8X2T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3371</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3371"/>
    <dbReference type="EnsemblBacteria" id="ADW70379">
        <property type="protein sequence ID" value="ADW70379"/>
        <property type="gene ID" value="AciX9_3371"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3371"/>
    <dbReference type="HOGENOM" id="CLU_2734377_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7900" checksum="8FCBF8FC0B589314" modified="2011-04-05" version="1">MIMTMPKSVKTTAKTGLLTKADRAFIADFSKSSQSHVDKVTRTKALAMKELVDAGIYDVHGKLRKRYRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X3</accession>
    <name>E8X2X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1044</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579430.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1044"/>
    <dbReference type="EnsemblBacteria" id="ADW68107">
        <property type="protein sequence ID" value="ADW68107"/>
        <property type="gene ID" value="AciX9_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1044"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_1_0"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="33366" checksum="32D7D7B7EA516A64" modified="2011-04-05" version="1">MDSHTDVKHLLKAGATLTDAALERLLPAPDTLPHSIHRAMRHSTFAGGKRLRPILALEAARMVSGGTLTPALETAAAELGAALEMIHTYSLIHDDLPALDNDDLRRGQPTCHVVFGEATAILAGDALQTLAFQTIANLHAPAATVVSILREVSAAVATGVGSVGDLHTSLPPGMIGGQVMDIESEGVKPTAELVEAIHRAKTGALITVSVVAGGLLGLGDQPSTTHDTIARLRTFGQKAGLAFQIVDDVLDMTQDSAQLGKTAGKDTATDKATWPAVFGIPQSIHDAEELIADAFAALARFAETAAPLKALANFLTERKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X301</accession>
    <name>E8X301_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_1072</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579458.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1072"/>
    <dbReference type="EnsemblBacteria" id="ADW68135">
        <property type="protein sequence ID" value="ADW68135"/>
        <property type="gene ID" value="AciX9_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1072"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_0_1_0"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="14345" checksum="5EC77457FD85A6F8" modified="2011-04-05" version="1">MTPTELAPTQLAELTRHAEAVASNAYAPYSNFQVGAALLLESGEIVTGCNVENASYRLTSCAEQAAIAAAVATHGPAIRIRAVVVVNLNGAACSPCGACRQTLAEFAAPGTTIVFPTETGTTTCTMADLLPNAFTQSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B2</accession>
    <name>E8X3B2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3407</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3407"/>
    <dbReference type="EnsemblBacteria" id="ADW70413">
        <property type="protein sequence ID" value="ADW70413"/>
        <property type="gene ID" value="AciX9_3407"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3407"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025367_0_0_0"/>
    <dbReference type="OMA" id="AKKFEVY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PTHR13377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="90"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="33836" checksum="E27A2DFE058D3BC1" modified="2011-04-05" version="1">MLPGTRALPYYQSRRDVSAGGAGSAYDGEIMARSGPISMTLPPFAGATRRLILWNVAVFFALAILAFGSRGLVSLLEIHLQLTPELALLHGEVWQFVTYAFINGSIINTAFAMLTLWFVGSLLEGSFGSRWLYEIYLISAIGGAVVASAVSMSHIERLQPIYAASGPYAGIFGLMIAIGAFFGDQEFLLFFVLRMKAKYLVAIYILVDVAMLLKSSDAFSALLQLSGGLCGYIFLRLAPRRGLAMGISERYFALRNEFYRAKRRRAAKKFEVYMRKQNREVHFDKDGRYVDPDKDPTDKRWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C3</accession>
    <name>E8X3C3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-trcl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3418"/>
    <dbReference type="EnsemblBacteria" id="ADW70424">
        <property type="protein sequence ID" value="ADW70424"/>
        <property type="gene ID" value="AciX9_3418"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3418"/>
    <dbReference type="eggNOG" id="ENOG5032UBV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115791_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026363">
        <property type="entry name" value="CxxC-x17-CxxC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04272">
        <property type="entry name" value="cxxc_cxxc_Mbark"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="21302" checksum="ACB57E44F8F56121" modified="2011-04-05" version="1">MQEQFIDRILNCVDCHGEFIFTAGEQLFFFDKQFKNDPKRCKPCKSRRSGLSAVANGTGPVAAGLSRTETRTLCSDCGIETTVPFKPTQGRPVLCRQCFQLKARSVTPLRTIGTPASDAAALTQASATIGGSISADAAVLAAASMSAASPQSSVATSADLASITQLEAPVSFPTAAQRTVQLIAGTSSDAMAADIPVELVAAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R7</accession>
    <name>E8X3R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2308</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2308"/>
    <dbReference type="EnsemblBacteria" id="ADW69345">
        <property type="protein sequence ID" value="ADW69345"/>
        <property type="gene ID" value="AciX9_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2308"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064918_0_0_0"/>
    <dbReference type="OMA" id="LGCHIEM"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="58"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="36110" checksum="5B826A79AE8705FE" modified="2011-04-05" version="1">MLPAQSPNPDGGGVQRGTLPLTWSTGGPKCLEMPEWQVHEYNPEFFILRQSGCTDFEKPFVYLIFGEKRALLYDTGSRNGNLAPTLQRVMHLWLLRNHRTSMPLVVVHSHSHSDHTAGDTDIQALTDPAIPITFIAANVEATKALYGIVNWPEDTGSIDLGDRVIDAVPIPGHDTVSVALYDRKTAVLLTGDSVYPGRLYIRDFDAFTKSNQRLMRFTQDKLVTHILGCHIEETRTPFLDYPVGTIYQPDEHELSLSRGVLLEMQSALDGMHGTPRRVAYADFSLWPSGPAFRAADKSQDTFKTTQEYQLKHMWDQTAPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T2</accession>
    <name>E8X3T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2323</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580676.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2323"/>
    <dbReference type="EnsemblBacteria" id="ADW69360">
        <property type="protein sequence ID" value="ADW69360"/>
        <property type="gene ID" value="AciX9_2323"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2323"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_2_1_0"/>
    <dbReference type="OMA" id="LKWIIKN"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234338" evidence="5">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="16705" checksum="336FCBC9868FB741" modified="2011-04-05" version="1">MQQTVAVRVVLSLLALGLSGCKATQPSKPETAVATWVKLHVTVGGKKDVNPVHADAAAIADGKQLFGSYCMVCHGLDGQNTGVPFAATISPPVPSLASAQVQAYSDGQLKWIIKNGLYPSGMPPSTGDFSDDDMWRMVVYIRHLPPKGSLGEPAVYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U3</accession>
    <name>E8X3U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2334</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580687.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2334"/>
    <dbReference type="EnsemblBacteria" id="ADW69371">
        <property type="protein sequence ID" value="ADW69371"/>
        <property type="gene ID" value="AciX9_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2334"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_0_0_0"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234144" evidence="1">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="33280" checksum="01D8471B3177E9E0" modified="2011-04-05" version="1">MGSRFGVALSVLFCVCTARAQTLVAPGVWFLLGDASKGYSNTTVIEMSDYLIVVDANYPGRAKELIALMPTLSKKPVRYVFDTHAHGDHSYGNSTWTRAGATTMAFAGVAKEMDRWEPKRWQTAVAKREDVRATGESDVERPRKIITGDKLVLKDKTREVDLLFLGWGHTPGDGYVWLPKERVLATGDAAVNGPRNKLWDASIENWPTVLDKALALKPVHVLPGHGEADGVEILVGQQRFLKDLFVAVNREAAAGKRPAEMHIELPREDANWVPKDLSGDIEACYTEVQAHAPAGSVPHEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B5</accession>
    <name>E8X4B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1179</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579565.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1179"/>
    <dbReference type="EnsemblBacteria" id="ADW68242">
        <property type="protein sequence ID" value="ADW68242"/>
        <property type="gene ID" value="AciX9_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1179"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_0"/>
    <dbReference type="OMA" id="QPKGHVS"/>
    <dbReference type="OrthoDB" id="1064766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="8"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="41421" checksum="37F319F3707BD337" modified="2011-04-05" version="1">MSNEAKQKLFTPIELASFQLKHRVVMAPLTRSRSDEPGDIPGALMAEYYAQRASDGGFIISEATNISIAGRGWYGAPGLYNDQQVEGWKKVVDAVHAKGGHIFAQLWHTGRSSNSLVTEGAIPVSASVDPEYWLDPAPTVSTANGWVTHSPHRALEVPEIKAIVEDYRKAAERAKAAGFDGVELHGANGYLPDQFLQDVSNKRTDEYGGSFENRSRLLLEIVEAMISVWGPNRAAVRIGPGGTWNHMSDSNPTALFAYLAEQLNRFDLAYLHIIEPRVKGNIVVDEGQEPIASQQLRKIFKGKIIAAGGFEPETAEAIVESGDADLVAFGRHFVSNPDLPKRIANHLPLNDYDRSTFYTFEAKGYTDYPFYEKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C8</accession>
    <name>E8X4C8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1192</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579578.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1192"/>
    <dbReference type="EnsemblBacteria" id="ADW68255">
        <property type="protein sequence ID" value="ADW68255"/>
        <property type="gene ID" value="AciX9_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1192"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187857_0_0_0"/>
    <dbReference type="OMA" id="FSHITIW"/>
    <dbReference type="OrthoDB" id="1425601at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234157" evidence="1">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="217" mass="23480" checksum="538417DB44B256F0" modified="2011-04-05" version="1">MNKALLSLALLLTAAGAAQAQGNLTETLAKLDAASAKFSNAQADVHNVSYNNVIKDIDDDQHGIVYFQRAKSGSQMGIKTDGKGARTVEYKNGTLRDYIPGSKCYNTVHNSSIETYLTLGFGGSGKDLASAWNIVDLGQETVDGIKVEKLELTPKDAGVKANVTKFTLWLDLARDVSLKQVLLAPTKDTHTATYTNIRLNQKIDTKPFEIKGNSCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I2</accession>
    <name>E8X4I2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribA</name>
        <name evidence="7" type="ordered locus">AciX9_2355</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580708.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2355"/>
    <dbReference type="EnsemblBacteria" id="ADW69392">
        <property type="protein sequence ID" value="ADW69392"/>
        <property type="gene ID" value="AciX9_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2355"/>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_1_0"/>
    <dbReference type="OMA" id="GQGFILY"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23545" checksum="6A59534F6E15DF11" modified="2011-04-05" version="1">MPFLSVRQLAEADFPTRWGHFRIYGFEGNVENPEPCNDAIPAPLVRIESAVALVMGDILAAPPVVRIHSQCLTGDVFHSLRCDCRQQLELALARIAQEGAGILLYENQEGRGIGLMAKLQAYALQDQGRDTIEANLELGYEADCRHFELHAEILKLLGVRAVRLMTNNPEKVEALEVGGIKVIERISADVPSEPTNEFYLQTKREKMGHLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J0</accession>
    <name>E8X4J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antidote protein, CC2985 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2363</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580716.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2363"/>
    <dbReference type="EnsemblBacteria" id="ADW69400">
        <property type="protein sequence ID" value="ADW69400"/>
        <property type="gene ID" value="AciX9_2363"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2363"/>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144805_6_0_0"/>
    <dbReference type="OMA" id="EADYENW"/>
    <dbReference type="OrthoDB" id="1897062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022789">
        <property type="entry name" value="ParD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36582">
        <property type="entry name" value="PTHR36582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03693">
        <property type="entry name" value="ParD_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02606">
        <property type="entry name" value="antidote_CC2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="10247" checksum="4403737500558A99" modified="2011-04-05" version="1">MNVSLTPELDEFVGAKVASGRYTSASEVVREALRLLEERDLERSSQLAAFNQELKQRLQSLERGEFVEMHEVRARLEQKSQERRRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M2</accession>
    <name>E8X4M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-selective porin OprB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2395</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580748.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2395"/>
    <dbReference type="EnsemblBacteria" id="ADW69432">
        <property type="protein sequence ID" value="ADW69432"/>
        <property type="gene ID" value="AciX9_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2395"/>
    <dbReference type="eggNOG" id="COG3659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545978_0_0_0"/>
    <dbReference type="OMA" id="DPRTQFM"/>
    <dbReference type="OrthoDB" id="1383921at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007230906" evidence="2">
        <location>
            <begin position="26"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="477" mass="52537" checksum="F561B22E2046BAC4" modified="2011-04-05" version="1">MVFRPKNLFLSLLLLGAAASLIAPAFGQDTEQPAPAGPAAPTMFPHPDSARYLILGQTNIIFQAHGPFHSPYSGPNSFLGRGEYKTSLLGTLYLGYQLNPHPRFATDILYDEESSGGRGISEALGLAGFTNLDVVRNPSLGSIPYMARVQLHQVIGFTDKMSDTPRTQFSLAPRLPERRLDLHVGKMSLPDYLDVNAIGTDSHLQFMNWTVDNNGAWDYAADTRGYTYGMVSEYVDDPHAFTARYAIALMPTVANGTNLEWNLRRASGQNVELELRKGIGTLVAPRLLGKRAGVIRTLTFVNHANMGDYRQQNQLALATGTTPVITAHPATVSVKYGLGLNVEQELTSNLRAYGRFGWNEGQHESYAYTEVDQSISGGLDLKAAAFSHRENDKIGVAFVSNAIKRDHQAYLALGGQGFLLGDGHLHYAREDILEAYYNLHAWRGVYYALDAQYVTHPGYNQDRGPALVESVRMHVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q7</accession>
    <name>E8X4Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3541</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581857.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3541"/>
    <dbReference type="EnsemblBacteria" id="ADW70546">
        <property type="protein sequence ID" value="ADW70546"/>
        <property type="gene ID" value="AciX9_3541"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3541"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533967_0_0_0"/>
    <dbReference type="OMA" id="GWDACLA"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="51407" checksum="D45D396B2CF42024" modified="2011-04-05" version="1">MASSGTLVVEEHRLDRQLGLRDLVLTQILCVVGSSWVGVAAGLGRAQTVMWVAAMVLFYVPMAAAVIGLNRAMPMEGGLYAWAHRAFGNLGGFLTAWNLWVYGLAVTATILYALPTELAYLIGPTAAWLPENHLASVGIVTFFLALLTIAALRGLNIGKWIHNVGGIAMLTIFAVLILLPLWGLARHMPIHWAPLAYELPRRDLRSLALFGQMLFGAQCGLEYVAILAGESKSPEKTIGRSVWISSPIICAMFIFGTSSVLAFSTPGHIDFIAPIPQTLRIALGSTGIGNLFAIAAIALLQFRLIGAASYIFTGVTRLPMAVGWDDLLPEWFTRLHPTRRTPTNSILCTAGLVFLLVVMGGFGVHAQEAYQLLQGASLTHYEIAYLAMFAIPLVGAGAVRKELPPSLKWISLVGLGATLFSLLISAYPVVDVISPLAFAVKILGTTAVSNLVALGFYMVRRRKVSEVPSVALETSADIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X546</accession>
    <name>E8X546_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1248</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579633.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1248"/>
    <dbReference type="EnsemblBacteria" id="ADW68310">
        <property type="protein sequence ID" value="ADW68310"/>
        <property type="gene ID" value="AciX9_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1248"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_3_0_0"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17218" checksum="03D35CC256B92A3F" modified="2011-04-05" version="1">MKPPAKTNAARILDQLAIPYELRPYEVDLEDLTAINVARKIGLPPEQVFKTLLTESSSGEHFFAVIPGDAELDLKKLAQATAQKKLDLASLKQVEPLTGYIRGGVTVLAAKKPFPAYADETIELFDIISVSAGQRGLQLILSPADYLRATAATLADLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X556</accession>
    <name>E8X556_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1258</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579643.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1258"/>
    <dbReference type="EnsemblBacteria" id="ADW68320">
        <property type="protein sequence ID" value="ADW68320"/>
        <property type="gene ID" value="AciX9_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1258"/>
    <dbReference type="eggNOG" id="ENOG502Z84I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454751_0_0_0"/>
    <dbReference type="OMA" id="NLIWFSG"/>
    <dbReference type="OrthoDB" id="1163339at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="630" mass="68217" checksum="AD072FDD4D0FABBC" modified="2011-04-05" version="1">MDLSSPLRRQTLRAPLLFAIALSLSLRTFSQQAPATATLRTRARLVVLDVVVTDKNKNPIHGLKKDDFTVLESNNPQKVGSFEEHAALTAAQAASAPPPPNFGPGIFTNYTPTPVNSAVNVLLLDALNTPHIDQAYARSQLIQYLKNARPGTNTAIFTLTTQLHMLQGFTSDPEVLRKVITKQTGRSSPLLDDATGGGGPPVSVTDQMTEELGGTVPAQVLANMQTFENDQNSFQLQLRAKYTLDAMNQLARFLAGIPGRKNLIWFSGSFPLNILPDTSGQSSDPFSAIASSETEYRETTNLLARSQVAVYPIDARGLMTSPSYSAAASGSKYVHNPGAFAKDESDFFFKTADEHGTMTRMAEDTGGHAFINTNGLTEAVAQAIDAGSNYYTLAYTPTDAKWTGNYRKIQVKLAQSGYTLAYRHGYYADEPGSAYSAVTAADTATTPRTDPALMQRAMAHGAPPQTQIIFKIRVLPTTTEEESRLVEGNVAVLGKINGPYRRYAVDFAADPSHIFFTHTPEDHYLARIEFVALVYNADGTLVNSIAQTVPVNVIATTFKELLHSGIPFHQEISVPVKGQYTLRVAMHDLHNNNIGVTELPIAAVKNLPPVPVPAQSPTPHTEAPSPPSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B6</accession>
    <name>E8X5B6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ordered locus">AciX9_2427</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580779.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2427"/>
    <dbReference type="EnsemblBacteria" id="ADW69463">
        <property type="protein sequence ID" value="ADW69463"/>
        <property type="gene ID" value="AciX9_2427"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2427"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_0"/>
    <dbReference type="OMA" id="TKFEFGF"/>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="32940" checksum="37ED0D658D4F2838" modified="2011-04-05" version="1">MESSALLTTDLGALPLLARGKVRDIYAVSPDPASDLLFIASDRLSAFDHVLGSGIPDKGRILTQLSLFWFDFVKDVVPNHLITADVSEFPASLQPFKAQLEGRTMLVKRAQMFPVECVVRGYLSGSGWKDYQATQAICGIPLPAGLRESDKLPEPIFTPAAKINTGGHDENISFATVIETIGAEHANALRELSLAIYAKASAHAATRGVILADTKFEFGLIDGQITLADEVLTPDSSRYWPASQYAPGGPTPSFDKQYVRDYLESIHWNKQAPAPSLPPEVVTNTREKYLQAFHLISGRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E1</accession>
    <name>E8X5E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2453</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580804.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2453"/>
    <dbReference type="EnsemblBacteria" id="ADW69488">
        <property type="protein sequence ID" value="ADW69488"/>
        <property type="gene ID" value="AciX9_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2453"/>
    <dbReference type="eggNOG" id="COG3500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730987_0_0_0"/>
    <dbReference type="OMA" id="HALNVNM"/>
    <dbReference type="OrthoDB" id="1278199at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="39994" checksum="B34787CB6155DB7E" modified="2011-04-05" version="1">MLKGLYLSLFLGPMVPVPAPKSVVDALVSAQVNTGGERSGFQLVFSMNKKSDLYRKLLPAGALDPMVTRVILVCTLGGTPNVLIDGIVTRHEVAPSNQAGQSLLTLTGEDLTVLMDVVQFPMLRYPCMPAIARLNLIVAKYAIFGIAPLIIPPLFDDVPLPTDKIPTQTGSDLAYIKKLASDFGYIFYLVPGPVPGVSVFYFGPDVRVPVPQPALNVNMDANTNVESLSFSLDGLAKKVVIMTIMDPITGKIPIPIPVPNISLLRPPLGARLTAPAKVEFPPDGGNKNSIEAIALALAKTGATGEAVTGTGTLNVLRYGRVLNAFQLVGVRGASSTYDGLYYVRTVSHSIKHGEYKQNFTLSRDGLISQTPVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K8</accession>
    <name>E8X5K8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3632"/>
    <dbReference type="EnsemblBacteria" id="ADW70635">
        <property type="protein sequence ID" value="ADW70635"/>
        <property type="gene ID" value="AciX9_3632"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3632"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_0"/>
    <dbReference type="OMA" id="NPYCQTK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="328" mass="35559" checksum="4E3692A452E228FA" modified="2011-04-05" version="1">MIFVTGASGFLGGRVVQTLCERGEEVTILARKSSDLSHLAGLNYNTVQADLSDPTLLAEALKPATQIIHCAACSTDWAPQATYTAANVTGTQNLVAAALQAPRLERLLHISTTDVYGYPIIPCDESHPIVDAGLPYNQTKGRGEQLVRDAQSKLPITILRPATIFGPRGKDFTLEIATLLRQRLMATIDKGAAPGGFTYVDNVVEAILTASSSPQTLGRTYNISDGTNATWRHYITHFAAQLKLPMPWIDLPFAAATQAARLFEIPHRLLHLGGRPLLTRHAVLLLGRNQEFPIARAIEDFAFNPAISFEEGIARSAAWVQSLPGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L2</accession>
    <name>E8X5L2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ordered locus">AciX9_3636</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581950.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3636"/>
    <dbReference type="EnsemblBacteria" id="ADW70639">
        <property type="protein sequence ID" value="ADW70639"/>
        <property type="gene ID" value="AciX9_3636"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3636"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_0"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="15"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="264"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="288"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="374" mass="41428" checksum="2C2A40DA301FDAC9" modified="2011-04-05" version="1">MSLEFEVSRTAEGGGRRGRLALPHGVVETPVFMPVGTAATVKAVPQDTLEVLGKDGVGAQIILANTYHLYLRPGHELIRRMGGVHKFMSWTRPMLTDSGGFQVFSLSKLRKITPDGVEFRSHLDGSKHFFSPEHSMAVQIALGADVMMVFDECVEHPATYERTRESMGLTHAWAARSKDYFKAHKAEVPWHEELGGKTQSLFGIVQGGMYADLRRESAERLVEMDLPGYAIGGLAVGEPREVTREMIARTLEWLPKDKPRYVMGVGYPDEIEEYARMGVDMMDCVLPTRAGRHGLVFVRVDGVPVRLNIKKLEFAEDKGPIDPTCGCMVCSRYSRGYLRHLFASGEALAGTLLSVHNLAFYLDTMARVRAGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q2</accession>
    <name>E8X5Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3678</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581988.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3678"/>
    <dbReference type="EnsemblBacteria" id="ADW70679">
        <property type="protein sequence ID" value="ADW70679"/>
        <property type="gene ID" value="AciX9_3678"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3678"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_11_1_0"/>
    <dbReference type="OMA" id="MPPTDQD"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="15591" checksum="03DA9D1EE5350DEE" modified="2011-04-05" version="1">MSSTLAKDCKSSIIPAMRYRDAHKAIEWLVTAFGMEKKAVYDAPEGHVMHAELTFGNGMVMIGSVVNGGEYSKLISQPDEIGGRSTQSICLIVTDATAIYESAKAAGAEITGELAEMEYGGKAFGYKDPEGHLWSIGEYDPWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z2</accession>
    <name>E8X5Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70876">
        <property type="protein sequence ID" value="ADW70876"/>
        <property type="gene ID" value="AciX9_4096"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4096"/>
    <dbReference type="HOGENOM" id="CLU_3382108_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="33" mass="3927" checksum="8EBBBC89F41889A9" modified="2011-04-05" version="1">MVRVSPPLELSHFYLFVLVYFSRVVIFTLLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X630</accession>
    <name>E8X630_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_4134</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
            <plasmid evidence="12">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572826.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70914">
        <property type="protein sequence ID" value="ADW70914"/>
        <property type="gene ID" value="AciX9_4134"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4134"/>
    <dbReference type="HOGENOM" id="CLU_063626_2_2_0"/>
    <dbReference type="OMA" id="APQFNIF"/>
    <dbReference type="OrthoDB" id="1942709at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27824" checksum="00528336ADFA66DD" modified="2011-04-05" version="1">MQIPFADIIQAFLAIGVRLSGLMLFAPFLGSAVIPARIKAVLVVALTFVIYPLVSRSLTPQPLNDWPLLVFRELLVGVSIGIATSVVFEAVQMAGQILSIQMGYSLINILDPNTQVDTTVIAMFHQSIAMLIFLRLDVHLWLIRAIGNSFTYLPPGGAQLSRPFMFTLIGAGSAILSIGVQIAAPVLSATLLTDIVLGLLGKASPQLPLMLLGPAVKSLLGLAILFTSLKYWPDMFRVLFIDSMGFADRLLHLAAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D4</accession>
    <name>E8X6D4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4242</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572930.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71018">
        <property type="protein sequence ID" value="ADW71018"/>
        <property type="gene ID" value="AciX9_4242"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4242"/>
    <dbReference type="HOGENOM" id="CLU_2916065_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6844" checksum="9B8B1910BE28CE53" modified="2011-04-05" version="1">MTDGHGTLPCWPTPIGVGLQHLPWQVRSPPITDQTRGHGTHTMAAIWQQYLVELLTESEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E2</accession>
    <name>E8X6E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572938.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71026">
        <property type="protein sequence ID" value="ADW71026"/>
        <property type="gene ID" value="AciX9_4250"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4250"/>
    <dbReference type="HOGENOM" id="CLU_049343_5_0_0"/>
    <dbReference type="OMA" id="LPPMRYK"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="33353" checksum="3EB3D5E73CFCBAA2" modified="2011-04-05" version="1">MIWSGVMPAMTTPFDEAMKVDHSFLAQHAAWQLGNGCKGLVMLGSLGEGATLEHTEKIAILKTAVRVAKDAPVVAAISHLSTEGAVKLAQEAEAAGCAGLMVLPPYVYTSDWREMKQHVATVIAATKLPCMLYNNPVAYKTDFLPIEMAELASEHENLTAVKESSADVRRVSAIREVLGDRLRICVGVDDVLVEGVYAGAVGWVAGLVNAYPAESVQLFELATAGKTVEAFELYRWFLPLLRMDTVPKFVQLIKWVQEQVGVGSERVRAPRLVLNGKELEVARAEFEKAHATRPQVTSKAFSEFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H9</accession>
    <name>E8X6H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71063">
        <property type="protein sequence ID" value="ADW71063"/>
        <property type="gene ID" value="AciX9_4295"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4295"/>
    <dbReference type="HOGENOM" id="CLU_470035_0_0_0"/>
    <dbReference type="OMA" id="YLDSMAW"/>
    <dbReference type="OrthoDB" id="970340at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="577" mass="60482" checksum="563A41569DE5129D" modified="2011-04-05" version="1">MLTAIAVSQAQIKPKPADLAAASTAMQQGIAAANRNDLPAAAAAFVRATQLVPTLEPPQAALGSILLAQGDLPAAARTLARAHTLDPNDLATTLNLARTLTAQADYPTALPLFHQALTSPNPPALSPEESLAYATTLSATGNPTEAQSQLTQALTATPDSALLHDALGVLLVQSRHLPEAVPHFERATQLDPAYTQAQLHLGTTLLLLGQPDQAIPPLRKAATQAPTSFDAHLQLGRALSAARQDQPALTELHRAAELRTPATPPAAIYDLALALEASGDSASSLPLFAASAHALGSSEALINYALARVQTGDAIGALPLYAKAVTLGPDSATLREDYGVAYLQQSDLDHAITQFRAGLALDPQSPHLHYDLGLAFKLKDDLPASITELQLASTLDPTLPDPAYTLGVIYMQQGRYPDAIAQLRRATTLQPTNGDAWALLGGVLKDSDDTPAGAQQAIEALRHASALQPDQPSLHIQIAALLIRTNQPEQAAAERKTAAELSRAAVAQQRASFSLRSGRTLLAQGKLPEAIVQLNAAIAADPKAPEPHTLLAEALTRQGKPAEAAIERQRALTLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P5</accession>
    <name>E8X6P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3919</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582213.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71195">
        <property type="protein sequence ID" value="ADW71195"/>
        <property type="gene ID" value="AciX9_3919"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3919"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_0"/>
    <dbReference type="OMA" id="NDECYSE"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="44054" checksum="4196F0CB374CB991" modified="2011-04-05" version="1">MRDDFPRIQRLPPYVFNITGELKAAARKRGEDIIDFGMGNPDGATPSHIVEKMIEAARKQQTHRYSLSKGIPRLRKAICNWYKQRFDVDLDPATEAIMTIGSKEGIAHLCLAVLDKGDTVLVPNPSYPIHIYGPVIAGADVLSVPITTSTEDFLNHIQDVIPRMTPRPKVLIVNFPANPTAQCVDLPFFEKLVAICREYGIWLVHDLAYADIAFDGYKPPSVMQVPGAKDIAVEFFTLSKSYNMPGWRVGFMVGNPELVGALSRIKSYFDYGTFTPIQVASILALEGPQDCVKQICDNYRSRRDVLVHGLNKLGWPVDMPKATMFAWAKIPEQYSHLKSLEFSKLVLEQAKVAISPGIGFGEYGDDFVRFSLIENEARTRQALRGLKDMFTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T7</accession>
    <name>E8X6T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3961</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582255.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71237">
        <property type="protein sequence ID" value="ADW71237"/>
        <property type="gene ID" value="AciX9_3961"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3961"/>
    <dbReference type="HOGENOM" id="CLU_025996_0_5_0"/>
    <dbReference type="OMA" id="DYDFCIR"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34386" checksum="794B93F3F21209CF" modified="2011-04-05" version="1">MNPPGYNPLVSVVIPTLGRPELVQRAVRSALAQTHGNMEVIVVSDGPDPATAEALRDFDPRVRHLTVEHGGPAAARNAGVLASAGDWINLLDDDDELLPGKVAAQLAIADAEDQRTMIACRCVFEQAGRKDIWPVRPIGEGESLGDYMLVRPGLRGRPGQINLHCLLIPRSLAVAMPSPTFADHEDWAWLLAAEHEGGARVRFVWEPLVVYHLSVSEMTRSRRTNWAESLAWADHHRAWLSARAYNSFLATKVALKAKRAGDRKGLRLIAGRVLGNRPGVLELGFLFGVLFAPLSLLDNVWKESLRSDDGAGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X9</accession>
    <name>E8X6X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3802</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582110.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71088">
        <property type="protein sequence ID" value="ADW71088"/>
        <property type="gene ID" value="AciX9_3802"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3802"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="NWRGQFA"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="27106" checksum="3F8FC656E6DF7E98" modified="2011-04-05" version="1">MDDISLNQTANRSSPVALVTGSTSGIGAAIARRLSNEGYCVVLHSRRSVQTGQALAAELGNAMYIQADLADDADRIRLVREAVSRWGRLDVLVNNAGISSVIPHADLMAALPAVWQELHEINVVAPFRLVAEAEVALREAARRGRPACVVNISSHAGVRPKGASIPYAASKAALNHVTRLLALSLAPDIRVNAVAPGLVDTPLTADWTAAQQLWRDGSPMRRPASPEDIAQIVMMLIASDYLTGEIVVADGGLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z6</accession>
    <name>E8X6Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sel1 domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3819</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582127.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71105">
        <property type="protein sequence ID" value="ADW71105"/>
        <property type="gene ID" value="AciX9_3819"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3819"/>
    <dbReference type="HOGENOM" id="CLU_000288_36_7_0"/>
    <dbReference type="OMA" id="YAEAMKW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="29193" checksum="E2A3830804A07D34" modified="2011-04-05" version="1">MDDKAQAGLQHIPSGSALTLHSAKSGIFARGRRDSANAASNPHYRRAVSDYNAGQFTEAAAGFLLAAEQGHAESQYILSTMYDAGKGLPQDSTQAEHWERRAAEQGHAYAQANLSFRYYNAGDFAEAFLWCQRAADGKLAWAQYNLGLMYRKGEGVARSDAEAAHWYRLAALQEFSEAQQRLGDLYSLGEGVSRSYSQAAAWYRKAADHGNAEAQFQLGHLYQTGLGVEHDYTEYRHWTRQAALSGHEEALREMKSREYRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X715</accession>
    <name>E8X715_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3838</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71124">
        <property type="protein sequence ID" value="ADW71124"/>
        <property type="gene ID" value="AciX9_3838"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3838"/>
    <dbReference type="HOGENOM" id="CLU_062618_5_0_0"/>
    <dbReference type="OMA" id="AHISLFD"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="107"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="31760" checksum="8BE9E46FB360859A" modified="2011-04-05" version="1">MQESKSRHCEGNRREAVVYADRSLVKNMTTKKKVQPKPKIQQYATPALEKGLDVLELLARQPEGLTKSQIARELQRTVSEIFRMLVCLQSRGYIAQARDERFVLTLKLFKLVQEHPPTELLVAKALPVMHRLAHSTLQSCHLGVVEGGQVVFLAQVNAPTNLGFYVKLGSTADLMEAASGYVLLAHQSPEQRVRMVQAWSAETGNKPPKDLELHLASIRKGCYEKRASYLVKGVVNVSFPVFDDRGAAIAALTVPFIQYTGSQVGVADVISALRVAAAEITETIGGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X729</accession>
    <name>E8X729_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3855</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71138">
        <property type="protein sequence ID" value="ADW71138"/>
        <property type="gene ID" value="AciX9_3855"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3855"/>
    <dbReference type="HOGENOM" id="CLU_2699543_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8149" checksum="41F6BE3EEE888B06" modified="2011-04-05" version="1">MRQSLSNDTNGMGLAQMSERDLKRIEVLREILAGRRTVESGAALVGLAWRQTFRLLPRYREFGGGSIISQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8X788</accession>
    <name>E8X788_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4370</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71322">
        <property type="protein sequence ID" value="ADW71322"/>
        <property type="gene ID" value="AciX9_4370"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4370"/>
    <dbReference type="HOGENOM" id="CLU_3290362_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="40" mass="4229" checksum="35F42BDA88264A3B" modified="2011-04-05" version="1">MVDDDGAFVPARSVTHSATLSIALQNSLTQTAEVFIIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X792</accession>
    <name>E8X792_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase-like Mu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4374</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71326">
        <property type="protein sequence ID" value="ADW71326"/>
        <property type="gene ID" value="AciX9_4374"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4374"/>
    <dbReference type="HOGENOM" id="CLU_028963_0_1_0"/>
    <dbReference type="OMA" id="RIGYHAL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015378">
        <property type="entry name" value="Transposase-like_Mu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009004">
        <property type="entry name" value="Transposase_Mu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09299">
        <property type="entry name" value="Mu-transpos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50610">
        <property type="entry name" value="SSF50610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="157"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="491" mass="55159" checksum="0F80B50C0A2FEE87" modified="2011-04-05" version="1">MHSGDKSPALAELTEAQREQAMSRFRVLRSHTERGVPLPRAAQAAGVGLRTIERWLAQYRADGLAGLVRQTREDRGRRKIPPEAVELIEGLFLKKPQPSAAAVHRRVLALCKEREWPSPSYSSVYAIISRLDPALTTLAHEGPARFRDQFELVYRHRASHPNAIWQADHTQLDVLIRDASGEPVRPWLTTVIDDHSRALAGYLVFAGAPSAFQTSLALRQAIWRKADPSWAICGIPDVLYVDHGSDFTSKHLEQVAVDLHFELVYSTIARPQGRGKIERLFGTLNTELLPELPGYLKHGKPTTEPKLSLSELDRAIGNFMLGTYNARVHREIGIAPQTSWSGNGWLPRMPDSLEDLDLLLISVAKARTVHRDGIHFQGIRYMDPTLAAYVKEAVTIRYDPRDVAEIRVFHRNRFLCRAVSPEHSGQAITLKDIQTARSAHRRALRGQIRERVTPVADFLSPHTETTGPPAAKTSIPQPKKSKLHTYREDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A2</accession>
    <name>E8X7A2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4385</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573055.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71336">
        <property type="protein sequence ID" value="ADW71336"/>
        <property type="gene ID" value="AciX9_4385"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4385"/>
    <dbReference type="HOGENOM" id="CLU_103758_0_0_0"/>
    <dbReference type="OMA" id="RWYAHAV"/>
    <dbReference type="OrthoDB" id="1526909at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25231" checksum="EAAC291F9A8A1F93" modified="2011-04-05" version="1">MASNLPLLEEAAAKLKHLLPEVVFVGGSTLDLIVTDQGSAPIRSTYDVDVIVAADYAGYSAFCDRMRDIGFENDTRPGAPLCRFLHGDLMLDVMSTQKGALGFSNRWYEGAIQTATPASLLSGKVIRLITAPFFLGTKMEAFYDRGENDYYMSHDLEDFIAVIEGREQLLDELAEAPADLRKYLAEATGKLLGNERFIEALPGYVPGDSISQRRIPIILERLRKMGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C7</accession>
    <name>E8X7C7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4411</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573080.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71361">
        <property type="protein sequence ID" value="ADW71361"/>
        <property type="gene ID" value="AciX9_4411"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4411"/>
    <dbReference type="HOGENOM" id="CLU_070764_6_0_0"/>
    <dbReference type="OMA" id="QPWRFLY"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="22922" checksum="781E1A14155160EF" modified="2011-04-05" version="1">MPGTIIPDYPIQPLISSRWSPFAFDDRSVSPDDLLALLEAARWSASAANEQPWTYFIATRDEPEEFARLLSCVEEVNMPWAKFAAVLMLGCARLTLERSGQPYLTAEHDLGLASANLVFEATARGLGVHQMIHIHRERARQLFQIPEGVKPVAGLAIGYAGADGRLTEPFQKEDETRRLRKPLNSFVFTGSWSEVAPLVKVSKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H9</accession>
    <name>E8X7H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4467</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71413">
        <property type="protein sequence ID" value="ADW71413"/>
        <property type="gene ID" value="AciX9_4467"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4467"/>
    <dbReference type="HOGENOM" id="CLU_057121_0_0_0"/>
    <dbReference type="OMA" id="WMEVGDR"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234276" evidence="2">
        <location>
            <begin position="23"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="374" mass="40900" checksum="BD4F585BBD4C4F12" modified="2011-04-05" version="1">MRLFASCLSLLASVSLPGAVRAQAPRPTPPTRNPLNSTYVPGKELPDATTPSPTLDGNYILGPTHPSAPEMTPAALVPRGSISTFTLTSSESALYPGIARDAGTFGTADPSDPARLIITTSHPAPYTRRVTVYLPAQRVSGAVLPFIVGADGPDPALFTALDSLIADRRIPIMAAISISNGSGDAQGSERGLEYDTMSGRYAEFVETEILPRVEREYNVKLSRDPEARATMGGSSGGSCALIMAWYHPELYHRVLTYSGTFVNQQWPFNAQSPHGAWEFHEHLIPAGSIKPLRIWMEVGDRDLLNPNVLHDNMHDWAVANENMARVLAAKHYHYQFVFARNAGHTDRAVKQQTLPEALEYIWRTYRTPVLGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K3</accession>
    <name>E8X7K3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573156.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4492"/>
    <dbReference type="EnsemblBacteria" id="ADW71437">
        <property type="protein sequence ID" value="ADW71437"/>
        <property type="gene ID" value="AciX9_4492"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4492"/>
    <dbReference type="HOGENOM" id="CLU_2105526_0_0_0"/>
    <dbReference type="OrthoDB" id="2230869at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="13420" checksum="6018D485FFD7984B" modified="2011-04-05" version="1">MEKVQVMYELEEFRLTAPPDQLGELFMEAVLEDMAQPHAKRPLQCVTVKMPLPEYLRMKRATQKWNMTYTDVINFCTQRVIPILESPSGRVAQKLEQHRLDSESRRALRAGRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L3</accession>
    <name>E8X7L3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4503</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573166.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4503"/>
    <dbReference type="EnsemblBacteria" id="ADW71447">
        <property type="protein sequence ID" value="ADW71447"/>
        <property type="gene ID" value="AciX9_4503"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4503"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029423_2_0_0"/>
    <dbReference type="OMA" id="HQWAKNA"/>
    <dbReference type="OrthoDB" id="1213919at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="496" mass="54222" checksum="F3354E7310FC75CE" modified="2011-04-05" version="1">MPSFIPNESTFTPTLSLPLCVDLDGTLIKSDTLVDSVLVLARQHPRLLLSIPGWILKGKASFKQHVTNTISLDVSALPYNKPLLEFLFNQHAQGRAIYLATAADRALADRIAAHHQIFTGVLASDGSHNLAGDNKYQAFIQQFGEQFSYIGNASPDLPILTRCIEPMVANPTSSLSAGLRSAHITPAHLFMDRANPAKAWLRAIRLHQWAKNVLIFLPLLLAHAWSVSHFAGSILAFLAFGLCASATYIVNDLLDLEADRRHHRKRRRPFAAGDLSAMSGCLIVVSFLAAAAALALLLPQVVGPFGSPLQHPFRFANWLLLYAVTTTAYSLKLKRVVLLDVIILSGLYTVRIIAGSGATGIEVSKWLAGFSIFFFLSLAFVKRFAELESLRLRGAAPANGRGYLISDIEQLRSFGTASAYASVVVLTLYISDLDTALYKHPGRLWLLVPVLLLWLSRLWLQASRGELDEDPVVYAITDKRSLLLGLAVVGIVVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V6</accession>
    <name>E8X7V6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PKD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4610</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71540">
        <property type="protein sequence ID" value="ADW71540"/>
        <property type="gene ID" value="AciX9_4610"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4610"/>
    <dbReference type="HOGENOM" id="CLU_326730_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="881" mass="88325" checksum="18DAAAE1D9D877D1" modified="2011-04-05" version="1">MRRTKFHLSGGFPATLVCLAVSLVFLFGCSGGGTGSPAAPSLKAPTSNVAGPYTGLAGTAVSFNGSASSDPQGQALSFSWSFGDGTIGTGASPTHAYAMAGTYTISLVVTDTSGLASLAAMTTASITPVADFSLNASPQSLSLAGGTSTTLNVTAEALNGFSGPVTVTVSGLPAGVTQTSTSYILTPGVPLMVQLRANTAVASAIMPFTVTATSGSLTHTEQVTLTTGTSADYSIISSTPALSIVPGSTQIMTVTATAVNGFNGAVMGSLSGLPAGVSASPASFALPLGTAVPVTVTAASAGLTAGNSVLTVLTSSSTATHNLPVTVNVGSQLQSIVLSTPASLSVPPGGSAIFDAITYGVGGYQGPVNIQVSGQPAGVTATPSSFTVNLSPVGIGSGEVKLTGASSLTNGTAPFTVTATVGTQTQQNDVVLTTAPANVVAATVNPAAPGTAFPPYFIGFSLPQVTLEELAGTGATTYPSFINLLANLQQYVGSPSIRTGLPTGTAAVLGPLTNAATFTANGVTTKPSYILGTSATYNPGQAASELAQAIAAVGSAQIKGVELDNEPDLYVRNGYRPTNWTYTDFLTETAGYQATMAPYLTQPQLVVSAESGRTWDPGIPALMTQLSGQISIFTAHLYALEACDTTPTIPQLMEDLSIARYFSRYGALVKTLNPVPVRVGEVNTVACGGFAGVSDTMAAALWVVDMAFEAKAGGAAGFNLHSNGTITGGPLPYDIAYSNNGSLTVHAPFYGVLFLAQAIQNDASPLPVAITQTAGNVKVWATIDAAGTLRVAVLEKDLDGPAQSKTVMLDLGTYGEPGTLTALTAPSLSATSGITIGGQTFDGTSDGQLTGPVVSTQVTPVNGVYTITVNDGTAAMLTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z7</accession>
    <name>E8X7Z7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4651</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573300.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71581">
        <property type="protein sequence ID" value="ADW71581"/>
        <property type="gene ID" value="AciX9_4651"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4651"/>
    <dbReference type="HOGENOM" id="CLU_296096_0_0_0"/>
    <dbReference type="OrthoDB" id="1385045at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="2">
        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="379"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114062" checksum="0CB9A62C3EB227B8" modified="2011-04-05" version="1">MDELEFYDQSALLARLTSALKKRPREVIFLVGSPLSAPASAGLLGVPNVSGMIDIIRGEFADDHNLLNQLDILISTAKDKRYQEAFRFLQSRRGPAVANELVRSAVLAACKPEARYRGQSGDEQSCQLLEADDSLWAVLPGGSAIASLITHNPDIFGKSLLTTNFDPLLEVAIGKAGGRHYRTIMQGDGNVSITSAVGCHVIHLHGYWYGSNTLHTLRQLTQQRPQLKASLNRLIRDRIVVVIAYGGWDDIFTTTLLEMVADDADNTEILWTTRSASPSFPANIAAQLKLAADKAKVLVYGDIDCNVFLPELASWWLANSVGHPLTPPVPVSPVKFESSLITQMTSAPPKNILLEGDLEDRPPVIEFCLGREAELVLLEAGSAVVFITGIGGEGKSTIAAKAFGDRQKQVPDNTYVWRDCKEEGERFENQLAAIVESLTSGRVQGLDLAKQEIQIIVDILIPLLTDKSFLFVFDNIDHYVDLETLRLTSSVEHFVTAVLERAHTTKLIFTSRPSIQFTHPSATTIRLKGLTLSAAKALFVARGAVSSELEIEDAHEVTNGHAFWLDLLAIQVAKQLPGSSLRTLVDEIRRGTGELPNNMLNSIWSKLRDRERTVLRAMAETVRPEREKEIADYVSSEMNFQKVFKALRTLRSANLVVVKRLRGGEEVLELHPLVRTFLRKRFSHKERLSFIDGIMRVYNHFIGLHRNQLSDRPTFVVLQNWTQAAELSVAAGRLGQAYAILAESVGAFSSSAYPREFTRVARLLLSSGDFVEEHRSYKKLDTVFKTHIELLSYLGEFQEVDSLLSRFALTVPEKDARFILYCQLRAYTFWVRKSFAEAVDWAKRGHTLQVNSNVDTDDSIGNVLGLALRDGGNPDEAMEIFLEGSRLEEFTDPDEFNQDHGGPHYGNIGRCLHFMGELNGALICYQKSALIIEKDSKHEHILNQGYIRLWVGEVLISRKQTLLGLMFLEAARRKWEQVNPLEAGRIAALQEQQDLFTPELRSRQNRVERSFQDWIVGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X833</accession>
    <name>E8X833_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71617">
        <property type="protein sequence ID" value="ADW71617"/>
        <property type="gene ID" value="AciX9_4688"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4688"/>
    <dbReference type="HOGENOM" id="CLU_041517_0_2_0"/>
    <dbReference type="OMA" id="GVFRSTH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="123"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="50734" checksum="E828510D5F6D119A" modified="2011-04-05" version="1">MSERDLRRIEVLSDVRAGRRTVVAAAAVLAISERQAFRLLARYEADGGGGLIHKARGRTSNRSHNEGIRKYAVELVKTRYADFGPTLATEVLLDKHQLRIGKETLRRWMMAEGLWLSRTQRRTFHQPRLRRESYGELIQIDGSDHRWFEQRGEPCTLLVFIDDATSKLMQLRFVPSESTDSYFEALNGYLTTHGCPTAFYSDKHTVFRVNRPDAKGGSGMTQFGRALAELNIEILCANSSQAKGRVERANRTLQDRLVKELRMAGICDMTAGNSFLPQFAEEFNNKFSIPAVRTENMHRRLNVQASRLADILCHREQRHVSQQLSLAYDRRQIILERSEMADKLTGQYVEVYDFSDRPLEVRWKGHSLPYRVFSKDQRVSHTAIVENKRLSHALAVVKAQQDIKHQPKIQTNSDKGGYKKRPRQVYGPDYKEIATAPAVEMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV61</accession>
    <name>E8WV61_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase with beta propeller sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0162</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578564.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0162"/>
    <dbReference type="EnsemblBacteria" id="ADW67236">
        <property type="protein sequence ID" value="ADW67236"/>
        <property type="gene ID" value="AciX9_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0162"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_28_4_0"/>
    <dbReference type="OMA" id="RELHDQF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1095" mass="119690" checksum="D8515DDD868E35A8" modified="2011-04-05" version="1">MVSSTMYWPQFAPDVAIQGPSALIIRSEHSAPGDTRLCRLLTFVALLAFLLATPSRPAAAQQSSFLSSQNLERIADLEFDTLNTKDGLPHQSIYSFTQDTAGYIWIATYGGLSRFDGYQLRSYTHDPAQPTSLRDNNVRVLLPAPNGDLWIGSDADGVFYYRASTDSFEDLPDAPAALKGLRVYCLISDGHGGIWAGGQFGLFHFNPNATNAAERYETFPSFAPGSTSSFTLKRVFSLFLDSHGALWVGGDPGVVMRPAGSSTFQPILGIDGEHEIGPRPYVWSFLEDHSGRLWVGCDHVGIAIYDSQSHSLRGVPGLSGAISEIGEHTVRGLIEPSPGEIWIATYGGGLVTYDTQDGFIRSFVKNSPSPAPLHNNFMRGIFKDSSGVVWMGTDNGLARINDAAGGIFQIHPSLLHPTRFSGTDVRSVGVVNGQVWVGFDQGEFGPVDQDAHVLKIEPAPGLPPSLITRREILAIKATAPDTVYVGGTGLFRVDLKSHTYRPSLDPLIDQEIVGSLCPDGNTLWAGTYNGLYALDLTTGHSQIFRHDPSDPTSISENDVRDLLLTRDGRLWISTRAGLDLRDPATGRFRSFRHLPGNPATLPGDNVRALVEDSHGRLWIATTGNGLAVLNHWSPAGTPIFHTLDTSTGLLSNSVLTVTLGLDGRIWANTSAGLSVIDPNTLTVQTYTAGDGLRSTSEKLFGSVTLPDGTLLFRSADGLLAVQPSHLEQRTYRAPLVMTAFTTADSHQSPFILAWQSMHGAVSLDPRKRGFEADVALLDYTGPESTRYSYRLQGLENDGLPNSSASDTNNQIWTELPPGLHTITFSALPPGTFTLLVRAVSRSGQGPLVESAFTINAPRAWTETLPFRLLLVLLTLGIIYVFIRLRTRVLDHRREHLEQEIELRTLELSEKSRQLELANLKLGQLAIRDSLTNLYNRRHFLDLAEAEYLRSRRSQRTFSLLLMDIDHFKLVNDTWGHFTGDAVIQMVADRISSSLRATDTAARFGGEEYIVLLPETSSPQAIQLAERIREAVAASPLQTTAQDIAITLSIGCAEFDPNATLTQLLERADKALYAAKNAGRNRIEADDATRRNESKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB0</accession>
    <name>E8WVB0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0211</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0211"/>
    <dbReference type="EnsemblBacteria" id="ADW67285">
        <property type="protein sequence ID" value="ADW67285"/>
        <property type="gene ID" value="AciX9_0211"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0211"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302641_0_0_0"/>
    <dbReference type="OMA" id="MIGLMIR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229945" evidence="2">
        <location>
            <begin position="25"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="985" mass="102448" checksum="36FA9524CD8789D4" modified="2011-04-05" version="1">MQLSSYLPALFFGLCVSFSCTLTAQTSGPVPQAKHTSLPIVFEENRGQFDASTRYVVRNAGGVVEFHANGPEFLMGTSKTRTRITLQPVTPATKTDLSSEEVTPGKVNYFLGQTATAQLQGISTYGKVRYSNFMTGVDLSFYGNGDNLEHDFILSPQVEPKSVVFRLNGAGSLKLKDNGELLIQAPGSQLLFRRPVGYQLIDGRRTSVDVAFVLSPGGDLSFQAGQYNHTQPLVIDPVLVFSTYLDGTHQDSPTSVITDNTGNIYVAGYTTSPDFPIANAYQSSCGTCTGGGFGEAGVLSKLDPTGKTLLYSTYFLGSGLTDIFRIKVDNFGNLVGVGYSASGFPKVGNYPGTYSSGTFVFSLNPAGTALNHAEVIGAGQSASSFNDSNGNPYGLAIDSSNNVYIADAVSLNVNGGTFPLPVTTGTYGSGNKVAGETTSIYVAKIGPDGSLFYGTLVPPINPSAAPYGFYLYMGGLAVDASGNLYVSATASAGMPTTANAASTAFPNTMPANTQYSGDAGYVFALDPKAAQLLFATYLPGTDSANTLAIAADGSLYVAGTTSETTLPVSANAFQAALKPGANCTCDGGYALNLSGDGGKILHATYLSGTIDYNNEVTAYGSTVLDSTGNVFIGGNVTSVDSPLQNPVVSYLDDTTNLYARGTYVAGLTPDLSKLIFGSYFSGPGAGDLLADMTVSPAGRLVLTGSTFSNTNFLTTPGALQPTAPAQPNPGVGYQHEFVASIDLTVPAPSVCLSSRSVNFGKVAVGNTNSVTFTLTNCGNAPLNISSLTSTSPVVSATPLSSALPAGQSYPIQVQFAPADSTVITGSITIASNAVVATQSVSFSGQGLAPQLAIQSPAATSPVAFPQMVLGSTPATTVAFLLRNTGNAPLTITSASVSGEFTLLAKLYEPACRKRHLLCLRSAGPQQRRVQARDPHTPLQRPHPSHTGSAPRRHCAPQLSRPGADLTQRAGTSNRRHQGLAYPHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB7</accession>
    <name>E8WVB7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0218"/>
    <dbReference type="EnsemblBacteria" id="ADW67292">
        <property type="protein sequence ID" value="ADW67292"/>
        <property type="gene ID" value="AciX9_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0218"/>
    <dbReference type="HOGENOM" id="CLU_1989489_0_0_0"/>
    <dbReference type="OMA" id="IAGKAHQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233403" evidence="1">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="12669" checksum="A1ED45802C19ED38" modified="2011-04-05" version="1">MTISTLKRQAALLVLPAMLACGLHAGAQYRDHGNFNNGVRDGGRGGYYGGGRGDDRYRNDDYNRNRGGIGPGKGALIGGAGGAALGALLGGGLKGTIIGGAAGAGIGAIAGKAHQNNQRNNYYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE5</accession>
    <name>E8WVE5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1331</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579716.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1331"/>
    <dbReference type="EnsemblBacteria" id="ADW68393">
        <property type="protein sequence ID" value="ADW68393"/>
        <property type="gene ID" value="AciX9_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1331"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_3_0_0"/>
    <dbReference type="OMA" id="SVAKYYK"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="DUF1939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="8">
        <location>
            <begin position="2"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="463" mass="52927" checksum="9692C22D7E6CB095" modified="2011-04-05" version="1">MAVMMQAFYWDAPKLENREHDFWNFIAERVEDLGKAGINALWLPPINKGSSNTSMGYDPYDFFDLGDFDQKGGTKTWYGNRAELEALITKAHANSVGVYADMVINHNSGADEEEVNPLDGEKRWTKFNPASGIFPRDWNSFHPSRFERTMVEGEHFAGFPHLCHRNPSVYKAMFDYARLIIEDLDFDGFRFDFVKGYGSWMISLLSKYQYEKKDMKEFMPYVVCELWSGGDDIDMWLDKANSVTDNQIAAFDFPLRYQLKAVCDQPNYDLRNLTRDGSVVMARPAHAATFVDNHDMGEDIIQNDKLMAYSFIMVHEGYPCIFWFDYYNNGLARPFTPNGINALIEAHHKYAGGDSQILHADPDLYIMQRVGWKDDKTDQPGLVYVLNNLGDKWSGTSVKTKWCNQRMVPIAWDGHGLYGEVAHPDERRTDAEGNCEFPAPPRGYCIYVPIADDANKDEAIAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI8</accession>
    <name>E8WVI8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1377</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579758.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1377"/>
    <dbReference type="EnsemblBacteria" id="ADW68436">
        <property type="protein sequence ID" value="ADW68436"/>
        <property type="gene ID" value="AciX9_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1377"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_0"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="104"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="18895" checksum="9B5FE7F17329340C" modified="2011-04-05" version="1">MPSKPGTYATFKTSQGTIVCELFEKDAPITVKNFIELAEGTREWSSRSKKGDKLYDGSIFHRVIPQFMIQGGDPEGTGMGGPGYKFADETKGSTHHFKEPGKLAMANAGPNTNGSQFFITVTDTSWLTGKHTIFGEVVEGYDIVEKISNASRDGMDRPKTPIVLESVTIERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM3</accession>
    <name>E8WVM3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2522"/>
    <dbReference type="EnsemblBacteria" id="ADW69552">
        <property type="protein sequence ID" value="ADW69552"/>
        <property type="gene ID" value="AciX9_2522"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2522"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_0"/>
    <dbReference type="OMA" id="NGWDREQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="22618" checksum="A50DED60B0D2EC92" modified="2011-04-05" version="1">MLTNGWDHLARKRAAKHFKLNWSEMDERHRLVFETHEEGKLSFEEYLGWVVFFEKRPFTRIQFRDFMFAQSKPYPKMLGLVAQLKAQHGLKIVVVSNESREINAHRIRTFRLDQLVDAFISSCFVGMRKPDIEIFRLALDLAQTAPERAVFIDNTPMFVQIAERLGMRSIHHVDYESTRAKFTSLGLQTNDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP9</accession>
    <name>E8WVP9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2548</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580893.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2548"/>
    <dbReference type="EnsemblBacteria" id="ADW69578">
        <property type="protein sequence ID" value="ADW69578"/>
        <property type="gene ID" value="AciX9_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2548"/>
    <dbReference type="eggNOG" id="ENOG503301F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154470_0_0_0"/>
    <dbReference type="OMA" id="WSTEKEA"/>
    <dbReference type="OrthoDB" id="2061585at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12176" checksum="054164F36AFCACDB" modified="2011-04-05" version="1">MSDVQAIRSVCDKLRRPLATLAGAAGFRSLLERALTLSKQECQILDAWEVEPNGSLRGLNGETAQWGGVLIAQLIGLMTTFIGESLTLQLLQNAWPNLPCSEVNYERCESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW7</accession>
    <name>E8WVW7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3725"/>
    <dbReference type="EnsemblBacteria" id="ADW70726">
        <property type="protein sequence ID" value="ADW70726"/>
        <property type="gene ID" value="AciX9_3725"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3725"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933048_0_0_0"/>
    <dbReference type="OMA" id="RNKAFDM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="34767" checksum="AE89B777D739020B" modified="2011-04-05" version="1">MRQLQSSKQRGPAGLLPGLFTGLCRAALPALMLFGLTGCYSIRTHTVGRTVVVTKVLDATLDQLLTQLAKQDDSIQTMNAKVDITASTGGEHEGEVKELPTFSGYIFLRRPGDLRVLMLVPLARSTGLDMVSDGTHFKLNVPYKQLAVIGEDKFTDSSKNGLENLRPYIVRDALLIPTATPDQYVTLTRGSRITPPGPGQKDSIEEPDYDITILSQTKDHVLEQLRVIHFGRITLQPYQQDYYHEGRIVTTVTYDKYQKFGELTFPQSILITQPTNELKLKIDITKLTLNQKLDDEQFVLQFPEGAKVKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW37</accession>
    <name>E8WW37_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0269</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578671.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67343">
        <property type="protein sequence ID" value="ADW67343"/>
        <property type="gene ID" value="AciX9_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0269"/>
    <dbReference type="HOGENOM" id="CLU_1822621_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15364" checksum="1BDC17D78DFFC2E1" modified="2011-04-05" version="1">MVSIQQVAEALMQKDVTVAALAPRLGIVEEKGMDDYRVKPDTPTILQISLGIPEGKDASAAPSFIEYYFAVDHPTHLAAALPGCKDWRQIPGNPGASPYLYSCRFAGSTERLEVNFVATLTEDIKTPTAALQTMILQRNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB2</accession>
    <name>E8WWB2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1441</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579816.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1441"/>
    <dbReference type="EnsemblBacteria" id="ADW68495">
        <property type="protein sequence ID" value="ADW68495"/>
        <property type="gene ID" value="AciX9_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1441"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_0"/>
    <dbReference type="OMA" id="FWGEFAR"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="35846" checksum="39B175A503B961A4" modified="2011-04-05" version="1">MKTWQLEKLGRANLHLVETPKPEPGPSEILVRSKAISLNFRDKAIIEGSYVIPIDFPLVPGSDLAGEVVSVGANVTRFKAGDQVVSTFQPLWLDGIPTVEARNATLGGPLPGVLAEYVLLPDTGALAYPEYLTPAQASTLPIAAVTAWVALFKHGNLQPSETVLIHGSGGVSLFGLQLARALGARVIATSRSATKIHLLKQLGASDVIDTTKYPAWDEEARSLTQDCGVDHVLEVVGGEYLQRSIAALALGGHVAVIGFMESMTSTISLPPLMLGNLKLQGVGVGSRKDMVELLNFLEHHRVEPVIDASYDFSDLPDALDHLDRGPFGKVVVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB5</accession>
    <name>E8WWB5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1445</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1445"/>
    <dbReference type="EnsemblBacteria" id="ADW68498">
        <property type="protein sequence ID" value="ADW68498"/>
        <property type="gene ID" value="AciX9_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1445"/>
    <dbReference type="HOGENOM" id="CLU_3382106_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="33" mass="3748" checksum="FF861AECC3F33A77" modified="2011-04-05" version="1">MQFVVGVLLFVLVVGLVDRRLPWPPAKQKEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC4</accession>
    <name>E8WWC4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579828.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1454"/>
    <dbReference type="EnsemblBacteria" id="ADW68507">
        <property type="protein sequence ID" value="ADW68507"/>
        <property type="gene ID" value="AciX9_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1454"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OMA" id="NTLMPGP"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26194" checksum="7DDB2A68134953F5" modified="2011-04-05" version="1">MSALDGKVAVITGGNSGIGLATAQRFVEEGAYVFITARRQTELDKAVALIGKNVTAIAADVTSLDDLDRIATTVKTQKGKVDIIVSSAGITEQGEIDSLTPEHFDKVFNLNGRAPVFLVQKLLPLMKGNGSIILVSSAMHLMGIPGHTAYAATKAAMRSYARTWAAEFKDRGIRVNTLSPGVTDTPMLSDQAAGLGDYDAVVNMYKSMVPLGRLARAQEIANAAVFLGSEQSSYLTGSDLMADGGIGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE7</accession>
    <name>E8WWE7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2586</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2586"/>
    <dbReference type="EnsemblBacteria" id="ADW69611">
        <property type="protein sequence ID" value="ADW69611"/>
        <property type="gene ID" value="AciX9_2586"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2586"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_0"/>
    <dbReference type="OMA" id="YPMIGSH"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="42"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="34243" checksum="F7F7493D906A01CF" modified="2011-04-05" version="1">MLRSFFISMSQNKSLRAFSEKSAVGKKLSSRFVAGMTVAAALEAAEQMNREGLAVSLDSLGESVMDEAHAHASAAIYHEVLDAIQQRGLNANVSVKLTQMGMDLDPSLAESIVAGMIIHAEEANTFVRIDMEGSEYTEATIQMTERLNARWPGRVGTVLQAYLYRTADDAQRLVEQGIRIRLCKGAYKEPAEIAFPEKSDVDENYERLMLYLSTSGVFCGMATHDETIIDTMRRFVEAKGLPKANFEFQMLYGIRRDLQRKLAAEGYGVRIYIPFGAEWYPYFMRRLAERPANVLFLAKNFFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG4</accession>
    <name>E8WWG4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2603</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2603"/>
    <dbReference type="EnsemblBacteria" id="ADW69628">
        <property type="protein sequence ID" value="ADW69628"/>
        <property type="gene ID" value="AciX9_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2603"/>
    <dbReference type="eggNOG" id="ENOG502ZADA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559925_0_0_0"/>
    <dbReference type="OMA" id="LNCGVEC"/>
    <dbReference type="OrthoDB" id="859788at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="487" mass="50921" checksum="24D7797536E12883" modified="2011-04-05" version="1">MKNRSFSARAVRGILMTFLLTVVSLSLTSCGQQLYKFPEFTFAGRPIPPSLLAYRVMVSLTPNGTTGALEILDGNRDLRGNVQNTKQSFFISGFSGANPTQILNFPEQLRGYVFSNASGNSVATVNYGTETSGGSAGSFPGSTSVATGSDGVRFYSADEAAGQVIVVDNQLGRTFALNLPNAYRVAVNQGDTVALAMVRNSNTLYRVLKLNNGGLAPPGNVDCEPQILPVYCVVPVPGSYDRPQAAYFSTDGATAYVLNCGVECGGGNNGGASVSFMPQSPLTINVIPTSAPYPAVVTNTVAIPGGATVALSDGSNLYVAGQQLQTDGLFAGRLTKVNLSTLAVSAAVSISDGNHSKLIFGDDNTLWIGSQYCATGERAKQGLNYNCLTRYDMGTGAASIIPANVVPGSTAAGTTVPYPNTDDNQYYYGSLSGICWVQSLHKMYTAYGGQIHAFNTADGSEINNFNITVQGTALDVAFIDAATNAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG9</accession>
    <name>E8WWG9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2608</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580948.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2608"/>
    <dbReference type="EnsemblBacteria" id="ADW69633">
        <property type="protein sequence ID" value="ADW69633"/>
        <property type="gene ID" value="AciX9_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2608"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_0"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="36163" checksum="5859CB7AF3D2550A" modified="2011-04-05" version="1">MSTISIATATEVMDLLRDDLLAIEREFTVQSASPVQVITDIAEYLIAGGGKRIRPLLLLLSAKALGATSQSRIRLGAVVEMLHTATLVHDDIIDEADTRRGRPSSNTAWGNSKCVLAGDWLYMQSFRTALEERNFHVLDLLITLTQQMVEGELLQMEKLGHLINEEEYFDLIFRKTAFLFKVSMQLGAAIEGASDQTEEKLGEYGRNLGLAFQIVDDVLDLTAAEDVLGKPVASDLREGKATLAVIHALERGTGADREAIRTVLADRSFAHVSHVQILEILQRHGSIDYAMDTACAYAEAARLSIADLPATDAKRALLWVPGFVTSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ1</accession>
    <name>E8WWJ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2630</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580970.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2630"/>
    <dbReference type="EnsemblBacteria" id="ADW69655">
        <property type="protein sequence ID" value="ADW69655"/>
        <property type="gene ID" value="AciX9_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2630"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_2_1_0"/>
    <dbReference type="OMA" id="MERGEIW"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12371" checksum="E1E3646665613BE0" modified="2011-04-05" version="1">MKRGEIYMVSLEPTQGHEQRGFRPVLVISPDEFNRLTRAPMVLPITNGGGFARRSGFAVSLDGMGLKTTGVVRCDQLRVLDLEARNARLVELVPRTTVIEVLSRMQAIFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK3</accession>
    <name>E8WWK3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2642</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580982.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2642"/>
    <dbReference type="EnsemblBacteria" id="ADW69667">
        <property type="protein sequence ID" value="ADW69667"/>
        <property type="gene ID" value="AciX9_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2642"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131687_0_0_0"/>
    <dbReference type="OMA" id="RKDLPAC"/>
    <dbReference type="OrthoDB" id="1388310at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="28682" checksum="C1946E73BFF5A10F" modified="2011-04-05" version="1">MDMRHHNSALKMGMLTLLAFLTSGPRLLGQAAVSGSSAAQSQARSPIVPSGDGITVDQVVAVVNGDLILESDVAEERRFGAFQPFSNPEGTYSREETVQRLIDRSLILQQARLQPDDAVTKEQATSELNELRGVIPACKQYRCETDAGWQKFVEAQGFTVAELTKHWQQRMQVLKFIEVRFRMGIRITQQEIKDYYDKTLLPAYAKRKATAPKLDTISDRIQEILLQQQVSNLLGDWLKTLRAQGSVRVMTASGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU9</accession>
    <name>E8WWU9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0355</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0355"/>
    <dbReference type="EnsemblBacteria" id="ADW67427">
        <property type="protein sequence ID" value="ADW67427"/>
        <property type="gene ID" value="AciX9_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0355"/>
    <dbReference type="HOGENOM" id="CLU_3062061_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="5714" checksum="4DEF572E01D8B9BA" modified="2011-04-05" version="1">MCPILAYEAGPLHFGMTCNLADLATGRKLTTVDCYTASKESLPAWANALQQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW1</accession>
    <name>E8WWW1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1469"/>
    <dbReference type="EnsemblBacteria" id="ADW68522">
        <property type="protein sequence ID" value="ADW68522"/>
        <property type="gene ID" value="AciX9_1469"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1469"/>
    <dbReference type="HOGENOM" id="CLU_2879571_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="6927" checksum="F0552AB5508A7C88" modified="2011-04-05" version="1">MASIDTYQLDLQADPTPEGPRSETEIAAAMAVFDSLRGICKDIYAELGGSEAVLQEIRESWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW8</accession>
    <name>E8WWW8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1476</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579849.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1476"/>
    <dbReference type="EnsemblBacteria" id="ADW68529">
        <property type="protein sequence ID" value="ADW68529"/>
        <property type="gene ID" value="AciX9_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1476"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_0"/>
    <dbReference type="OMA" id="TGKIQPE"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="158"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="43040" checksum="6CCD519BC7AD20F2" modified="2011-04-05" version="1">MAPKKKSRKVLYFSISAVVLVGVLGLTAVAHGHSGAIDPAQLVRVERTDIAKSVVATGKVHPITQVEVKSKASGIVTQLSTDINDTVRRGQVLAQLDQQEILDQVAAQKATLAAAESNAHAAESAIVLDRVNAEAPDLPMIKHTYDRARQMNSDGVVSAQALDDAQQRYLAANNTRDKALSQITIDTAKLRQAQAQVAQAEAALKQLQEQLSYTTITSPMDGVVLSRDVEKGDAVSSILVLGSTATLVMTVGDIHQVYVQGKVDEADIGKVYMDQPARIKVESFKDKTFLGKVTRIAPLGVEKDNVTTFEVRVSIDNPGGELKSNMTANAEILLDEHKNVLAVPEQAVKFDKDRKATVEIPDKTQKTGRKFVPVVAGLSNGSKVEIVSGLKQNDQVILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX26</accession>
    <name>E8WX26_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1534</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579906.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68587">
        <property type="protein sequence ID" value="ADW68587"/>
        <property type="gene ID" value="AciX9_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1534"/>
    <dbReference type="eggNOG" id="ENOG5033142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2806440_0_0_0"/>
    <dbReference type="OMA" id="PKAGAIK"/>
    <dbReference type="OrthoDB" id="2034193at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="6951" checksum="3B89783569E91B0E" modified="2011-04-05" version="1">MSDFIPKAGAIKVGGLGRQAQKLQAAREKAANVKSGSKAVPGASVASFKAKDSFANTKKTTFQRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX49</accession>
    <name>E8WX49_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581006.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2667"/>
    <dbReference type="EnsemblBacteria" id="ADW69691">
        <property type="protein sequence ID" value="ADW69691"/>
        <property type="gene ID" value="AciX9_2667"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2667"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065962_0_0_0"/>
    <dbReference type="OMA" id="WQTDKNY"/>
    <dbReference type="OrthoDB" id="1379602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="30165" checksum="8F6B5128EBE5A84A" modified="2011-04-05" version="1">MPMLSVAIITCNEEYNLARTLASVSFADEIVIVDSGSTDRTVEIAQSFGAKVFEQSWPGFAPQKNFAIAQCTGDWVLSLDADEELSPKLRTQIQTLLPSNPPADAYFLKRRNLFLNRWIRHGGYYPDPKLRLFRRSTANFSLTPKFEDRSVHETIVFDGHSDTLDYDLIHHAYPTLEGYLEHMDRYSTLGAELLVTAGRTSREWPAFYWNVLIVPTLTFGWNYIFRLGFLDGREGLLLHLYHSAYVSWKYAKAWRAALLLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI4</accession>
    <name>E8WXI4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ordered locus">AciX9_1547</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1547"/>
    <dbReference type="EnsemblBacteria" id="ADW68600">
        <property type="protein sequence ID" value="ADW68600"/>
        <property type="gene ID" value="AciX9_1547"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1547"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_0"/>
    <dbReference type="OMA" id="HRFLYAE"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="109"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="34467" checksum="98CBA456B4FFAC9B" modified="2011-04-05" version="1">MGTGNGRLLSEYGVYLRVERGLRPNSCEAYGRDLLQFAEFLEKRDGLLVGATQQDVGEFLGQLRGHAVESRSVARKLSGLKGFYKWLLMDKRVRHDPTLNVASPSVWKILPKSMAESEVVGMLERTGVAARAADADGIALRDHAILELLYAGGLRVGEICALRVEDVRLEDQRAQVRGKGDKERIVPLGRQACDALAIYLDRGRPGLARGAGAGMRREMFLSVRGRALTRQWVWEMVRGCSENGDASPHKLRHSCATHMVEHGADLRSVQTFLGHADIATTQVYTHVALGHLKEVHRLHHPRAKRRMGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK2</accession>
    <name>E8WXK2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ordered locus">AciX9_1565</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1565"/>
    <dbReference type="EnsemblBacteria" id="ADW68618">
        <property type="protein sequence ID" value="ADW68618"/>
        <property type="gene ID" value="AciX9_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1565"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_2_0_0"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="129"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="383" mass="41604" checksum="261409279B32E9D3" modified="2011-04-05" version="1">MSCQLEAVDWYVMTGLGNGGALFGLSGAELRALVEDMGERPFRAKQLIDGLYKQRVGAVEEITTLPIAVRERLAAEGWVVGLPELAQTAKSVDGTERYLVRLADGETVETVWMPGGDGAELQEGDEGPGYKRATICVSSQVGCAVNCQFCLTAKLGMRRNLTAGEIAGQVTAVLNRQGIVIGKDRINLVFMGMGEPFLNYDSFMDAVRLLVNEMGIPASRMTVSTSGIEPAIRRFALEPIRPNLALSLNASNDVVRESIMPITRKWDIEALLDAVKSVPLRRQEYVTFEYVLLGGVNDQPEHAREVLALLKGMQAKVNLIVWNPGPGVAYEQPSQEAADAFHKMLVVGGVPAFTRRPRGRDIYAACGQLKRTVEEPGLVTIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM2</accession>
    <name>E8WXM2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1585</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579957.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1585"/>
    <dbReference type="EnsemblBacteria" id="ADW68638">
        <property type="protein sequence ID" value="ADW68638"/>
        <property type="gene ID" value="AciX9_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1585"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047123_2_0_0"/>
    <dbReference type="OMA" id="VREPSWG"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007195">
        <property type="entry name" value="TolB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04052">
        <property type="entry name" value="TolB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234147" evidence="4">
        <location>
            <begin position="25"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="TolB_N" evidence="5">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="48144" checksum="CF4AC41F01D58646" modified="2011-04-05" version="1">MQTKPHLRLFAAALLVLLTATLHAQGDIKLELSGSGADRIRLATANFKSGTLDPKNDALRHTFDTVLYDDLHNAGIFDMVSKSMAPQATPGSPTEINLPQWSGAPVNASMVAFGALGVTGTRLAVNGFLFDVKNTQFPQVLAKQYGEEASEDAARQIAHRFADEIILRLSGGTNGIAETKIYFVHLDGGNKEIWEMDYDGSNQHPVTSLGSVSVSPRVSPDNTRLAFSSLGKDGFQIKMFSLLLNRMVSFPAGGGGTNVSPAWSSDGKQLAFSSSRTGDNEIYIADANGGSSRRITSFAGPDVSPVFNPRSGAQIAWISGRSGLPQLYTMETDGSGVTRLTDGGYATSPSWSPNGQFLAFAWNRKYGPGAPGGQDIYVMEIASKRWIQLTHDMGPCDFPSWSPDGRHIVFANSPNGRASSSKIFTMLADGTDRHALTGAGSDMPNWSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU3</accession>
    <name>E8WXU3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2764</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2764"/>
    <dbReference type="EnsemblBacteria" id="ADW69788">
        <property type="protein sequence ID" value="ADW69788"/>
        <property type="gene ID" value="AciX9_2764"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2764"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_0"/>
    <dbReference type="OMA" id="GWWVLAP"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21878" checksum="FF0A967828CCD384" modified="2011-04-05" version="1">MSNPLPQPFQFVTPRLILRPFEDRDRAPFIAMNLDPEVMQFFAAPFTPERSEESIARYHRQLLRDGFTFLTAEHAQTGAYVGIVGMQVMSTIVPNLPQPAVEIGWRLTRAAHGHGYATEAARAFVGHAFNTLHLPELVAITATSNQPSRHVMEKLGMTHRPELTFNHPMVPADHPHNQHVLYSLQNPNAEEAPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW7</accession>
    <name>E8WXW7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2789</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581127.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2789"/>
    <dbReference type="EnsemblBacteria" id="ADW69812">
        <property type="protein sequence ID" value="ADW69812"/>
        <property type="gene ID" value="AciX9_2789"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2789"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342863_0_0_0"/>
    <dbReference type="OMA" id="KPAFGAR"/>
    <dbReference type="OrthoDB" id="773848at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="759" mass="80676" checksum="A8C0E5073B785698" modified="2011-04-05" version="1">MNPTNTAPTADQLSAARLTHWHQDATPLLTIEGLREWITRSGLVLYASRAAQLPSPAPSLVEATLGIPSTDPTLEAQTSAKSLLARLIAEGSAVPLNLLGATGGVGTDTPDFVCSAAVFSFIFTLRGNKAWKQSPVTSGPVKVSPLALAAYEILAAKVTLNVSELTAQLGKEVTESAVLRSLTELWSQLRVLPVPQQDGSPTLWELASARFTKQIKAGANAGQPTALSALISLYLGQAVCATEEEVETFLSPLAPRSRLRDVTHALLAARQLESLVIDGKTLLHVMGDSPAFVAVAVPEESEEATDSEAAVEGDPDAPRIRKFTPNPASKIGTGLRSRPSFGDRKPAFGARSGKPSFGSKPAFGSGDRERRPFVKRDDDRGARPTFNKPWDEDRSARTPRPDSGSADQGTDAPRTFTPRPSRPFGDRPSAGAGRPGGFQKRSFGGDREGGPRKTFSKPGTFGRKREGGFDSKPSFGGDSRPPRRDFGDSPRPSFSDRPSFSDRGDRGERPAAGGFKRPGSYSPRPSFGGKPSFGGPREDRGERPSGGGFAPRKPFTPREGGGGSFDRPSRPSFGDRPSYDRKPSFPRNEQSGGGSGEAPRKVFRKFDAPRTPKPFGSKPAFGARPSFGSKPAFGGPRPDRGDRGDRGDRGERPSSGGFARKPFTPREGGSSDRPYTPRPAGTFDRPRPSFGDRKPSFGGGGGRPSGGKSFGDRKPSSFAGKGGPFAKFADGKKPFRKPGPGKPSSGGFNPTRRQRPDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY0</accession>
    <name>E8WXY0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0447</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578847.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0447"/>
    <dbReference type="EnsemblBacteria" id="ADW67519">
        <property type="protein sequence ID" value="ADW67519"/>
        <property type="gene ID" value="AciX9_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0447"/>
    <dbReference type="eggNOG" id="ENOG5032N96">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098258_1_1_0"/>
    <dbReference type="OMA" id="GTHYRIK"/>
    <dbReference type="OrthoDB" id="1911879at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230438" evidence="2">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="11991" checksum="F77765DA6FC7B443" modified="2011-04-05" version="1">MTRPLTIAATLLTTATLYAYPPETTSFYPVCPIHALTGLLCPGCGATRALSALLHAHLTQAWHLNPLIIALLPLALAYATLILIKNHPPKIPPPLIYTLLAITTIFTITRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY2</accession>
    <name>E8WXY2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0449</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578849.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0449"/>
    <dbReference type="EnsemblBacteria" id="ADW67521">
        <property type="protein sequence ID" value="ADW67521"/>
        <property type="gene ID" value="AciX9_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0449"/>
    <dbReference type="eggNOG" id="ENOG5033UT5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114583_0_0_0"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GYF_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="27548" checksum="ED039D08ACEE3496" modified="2011-04-05" version="1">MHYQISRNGQMYGPYTLEDLQRYVVSGNVLPTDLAKSEEMSEWLPVSEILAGRTTGFSSGAPAPAYSAPVFTPAFTPNPGAPQFNPAAAASQYPDAPNLHWGLVLLFGFLTCSFFMIIWNLVVAAWLKRVQPNATSMMYYIGFVVLTVLQIFFGGFNGFHDAMMMRHSGVHSSFHPVAGLIGLSAWVVKLIARYSQRASLEEHFNGPEPVGLRLNPVMTFFFGGVYFQYHLNRINQIKTAARYGAPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY37</accession>
    <name>E8WY37_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0504</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578904.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0504"/>
    <dbReference type="EnsemblBacteria" id="ADW67576">
        <property type="protein sequence ID" value="ADW67576"/>
        <property type="gene ID" value="AciX9_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0504"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233478" description="PBP_domain domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="3">
        <location>
            <begin position="112"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="428" mass="46629" checksum="BC9FDB99ACCDF852" modified="2011-04-05" version="1">MNKSQANVAWIASVPAMALGLALTAPMAAQTTPAPAPKPAGTGHADDAPNGNRSIWTLDVTADRKKHATMGGYTKKWDLSDLPHYLPKQHPTGTLRIWGSNYLKDGPLGAYWADAFKKFQPGITIEYNLPTAGIAVPALAGKVADLAVGRPATLMDYLTFEQVFKYEPTEIIAATGSYDVYGWSPGFIILVNSQNPLTQISMKQLDGVFGTARNGGYDRSIWRTDYPYRRGAEDNIRTWDQLGLTGEWAGKPIHPCGQSPRANVQNVFQSLVMHGSDQWVEGYSTYANHATPEGKINAWSTQVTKQVLSDSQSICIASPLTITPDGMRELAIQGFNGGPFVKRTLETTRDRSYPLINEIFFYANKPPGQTADPKVDEFLHFILSQEGQQEIQHEGRYTPLTGAVVKAQILKLEPSAGSKATSEGGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY39</accession>
    <name>E8WY39_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0506</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578906.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0506"/>
    <dbReference type="EnsemblBacteria" id="ADW67578">
        <property type="protein sequence ID" value="ADW67578"/>
        <property type="gene ID" value="AciX9_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0506"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="PLNGRDW"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="452"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1156" mass="122109" checksum="E50E75F18D99A757" modified="2011-04-05" version="1">MKKIGIGISQIEYGSTSATGGGVRLLPLTGMAMLMLAASGFAQTSGGTVSGTVLDPTGAALPGAKVQVVNIATNATVDLTTGDSGLFNAPNVNPGNYQITVIAPGFNTQKINTLVEISKTTVLKVQLEVERVGATITVSSAVAPVVDLESSSLNQAVDGRTVRELPLNGRDWTQLSVLEPNVHTVDNQLSISAGDNSRSNRGVGNQISIGGTRPQQNVYRLDGIITNDYSGGGPGGALGGTLGVDAIQEFAVTTSNSTADYGRTSGGTISAVTREGTNAFHGSAYEFIRNSALDAKNYFSTSQFIAPFKRNQFGGSIGGAILHDKLFFFFNYEGLRQSRTTTVTDTVPSVNGRAGLLVCTQTATASNASCLNAPGGTKAPANSAGVQQIAVSPLVAPYLMFYPLPNGPVTGDTGSWTFNSKAVASENMFTGRLDYTIGPKDAIHFTALNDSSTDAQPDAFNFVVTGLQPDRKMYSIAEAHTFSPKIVNFVRAGYAYTFTVAPASSTAIQPSASDTSFGFVPGATVGNLQVGGLTSFFGGVNVEGVYSYHYNSYQFGDDVYITKGKHNIQTGFSFEAIQSNNRGTSTAGFYAFGSLQTFLQNAPTSFTSSVPGGSTPVYMREKIYGAYIQDAYHIRPNVTITAGMRYEPTSAISEAHNHFGVLTSPTSTLPRLGGILFGNPTLENFAPRIGVAYDPFGKGKTSIRAAYGIYDTLPLTYMFNLSTLNVAPYGQTISVTNTAALAGTFPKQTYANAVGTTIPCTLAAITGGGANPTAGCKIAFIDQDPRRPYVQQYIFSLQQQVAKGTTLEVGFTGAHGVRQPMKSNDGNIVEPINPGSYNLLWPSATTVTTTTAAGAATTKTTYSGTKINPNVGQTDTTYFNESTTYNAMNVALRRSIGSTRIGVSYTWSKSTDESSSSNGGTNFVNSIIAPFPREINRFKGLSDYNVKDNLTVNVLYTVPGPKNGTFMRLIGDGYQVGGIARVATGLPFTPLISGDPLGLQSASVFSFPDRLNTTGCTGNPVNLADKFNYLKRSCFAFPTGNTISNATATAANGSVTTTRVFNPALGNVQRNSIIGPGVTDMDISLVKNTAIPKVRDGFRVEFRAEVFNVLNHPMFQVPSRQSSAVFNATGTPLTSQILSLTSVPERQIQFGLKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY51</accession>
    <name>E8WY51_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68678">
        <property type="protein sequence ID" value="ADW68678"/>
        <property type="gene ID" value="AciX9_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1626"/>
    <dbReference type="eggNOG" id="ENOG5030X8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929884_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233979" evidence="1">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="32143" checksum="15C97A333601F8C2" modified="2011-04-05" version="1">MKTTGLGLAAVLVCAAAPLFGQMQGVSKPEQVPVTTSSEGISQPVVYEGGALPSVVMTPAKAPTEPMLKVRTEPALEARAELKADEHTNVTEKDDAVAIRAMDRRPLTGALPDPDAGIVTRVEGPSNQLPLGTLFKVRMHEGLTTTGTIAGQEFHADLLEPVERDGRVLIPAGSIMFGRVTDVHGGRRISGSASIHLQPLSVTLPDGTKYMIKGQVIDTSLYNETKVDHEGTILRKDHVGKTLTAMSLTTGAGAAAGAVFGGGVGALVGAGIGAGVSTAWWLKQDRQTELPVDTKITFALTTPLTVGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY59</accession>
    <name>E8WY59_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1634</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580005.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1634"/>
    <dbReference type="EnsemblBacteria" id="ADW68686">
        <property type="protein sequence ID" value="ADW68686"/>
        <property type="gene ID" value="AciX9_1634"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1634"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048595_0_0_0"/>
    <dbReference type="OMA" id="EELHYTR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="13112" checksum="9585BEF97A3ACD21" modified="2011-04-05" version="1">MALFKKARGKGIGSLATSLFNQRRRVATFAAAGLAVAVGYHVVFGHNGLTVYEQKRQETISLDRQLNDLNRDNDRLQGHVDRLQSDPNAIEHQAREELHYTRPGEVIITLPPDPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY80</accession>
    <name>E8WY80_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580026.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1656"/>
    <dbReference type="EnsemblBacteria" id="ADW68707">
        <property type="protein sequence ID" value="ADW68707"/>
        <property type="gene ID" value="AciX9_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1656"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="YPFVSMQ"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="45704" checksum="BAB6AAC59F8851AA" modified="2011-04-05" version="1">MKTILEAWSPETQHDRRAIILELDCILASPHFSNSKRYPALLRYIVERALEGRAHLLKERTLGIEVFQRSVDYDTNADTVVRYTAGEVRKRLSLYYHQHDSTHGIHISLPVGSYVPEFLKEHEPETDPGRTGLLLIDEQNSPAVATVATVQSDVVTISPSHGSPRMLWLIVIFVLLASLGVASLWKFGPVSSNAVDQFWGPVRQEPSTALLCVGGNVFDGNHFSGTMTAGKDIQYPFVSMQLASAIARVGGLLERLNTRYQIQASAPTPLGDLRERPVILLGGYNNPWTMRLVETLRFQLPPEPFEGIVDRDHPGRQWTRDKSQPYASTDDYALIARFRDARTGNVVFLLAGLGRNGTEGAAQFATSPLYMEQVSKRIGKKLSSGNLEMVIKVNVIDGKTGAPSIEDLWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA3</accession>
    <name>E8WYA3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1680"/>
    <dbReference type="EnsemblBacteria" id="ADW68730">
        <property type="protein sequence ID" value="ADW68730"/>
        <property type="gene ID" value="AciX9_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1680"/>
    <dbReference type="eggNOG" id="ENOG5033EKU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989491_0_0_0"/>
    <dbReference type="OMA" id="RMSAGSK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234160" evidence="2">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="13809" checksum="9089D4A509F818D0" modified="2011-04-05" version="1">MNITQTIRSTATAFALASGFLLAAHAQFPTQQPQSPNSQMGTHKSGSDSDIDARMSAGSKEKMAIARNDDRQKRLVADTDKLVALVTQLKTDVDKTDKYMLSLDVVRRSEEIEKLARSIKERAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC4</accession>
    <name>E8WYC4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2807</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581145.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2807"/>
    <dbReference type="EnsemblBacteria" id="ADW69830">
        <property type="protein sequence ID" value="ADW69830"/>
        <property type="gene ID" value="AciX9_2807"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2807"/>
    <dbReference type="HOGENOM" id="CLU_2395588_0_0_0"/>
    <dbReference type="OrthoDB" id="208162at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10824" checksum="52F17C3D417E3E93" modified="2011-04-05" version="1">MNSYAWKRDQDALGGTGGSYLKFENHWVDLLECDVRIKVHITDNYRANENRPFSRDVLWWSIEPGHTDWIPMPSNLVFGNFGSRRAREAAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH4</accession>
    <name>E8WYH4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cys/Met metabolism pyridoxal-phosphate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2857</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581195.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2857"/>
    <dbReference type="EnsemblBacteria" id="ADW69880">
        <property type="protein sequence ID" value="ADW69880"/>
        <property type="gene ID" value="AciX9_2857"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2857"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_2_0"/>
    <dbReference type="OMA" id="PTVMEFE"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="39374" checksum="A32C85630855B3E3" modified="2011-04-05" version="1">MHPETKLLHAALTPATAGEPLHAGPVFATAFHTPGDPAQAPYTYARSHNPTWTHLESAISGLEHPEAQTRIFASGLAAVHAAFASTLRPGDTIVFPDNCYFTARQLLQEHFAPIGVYLRPVPTALLTDPATLSGARLLWLETPSNPNLEITDIRAAVAVAHAAGVLVAVDNTTATPYAQQPLALGADLSVSSDSKSLTGHSDLLLGHVSTRDSALAERIDRHRTLTGAIAGPMEAWLALRSLATLPLRLDRTCANAQAIAEFLQTRFEVTEVLYPGLPTHPGHSIAAAQMTHFGTVVCFTLPSEQAANQFLTNSALITQATSFGGQVTTAERRARWGHDRIAPGFIRLSAGAEHLADLVADLSRALDSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR6</accession>
    <name>E8WYR6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1704</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580071.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1704"/>
    <dbReference type="EnsemblBacteria" id="ADW68752">
        <property type="protein sequence ID" value="ADW68752"/>
        <property type="gene ID" value="AciX9_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1704"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445946_0_0_0"/>
    <dbReference type="OMA" id="YNSCESS"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="229"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="372"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="598" mass="65412" checksum="B52BA2476B36DA1C" modified="2011-04-05" version="1">MNSARFDNILRQVLIVPIFAVLLGAAGLYWQIHDANRTVGFIQAADDRITHTLFVERLILDQETGLRGYQTTNDDQFLDPYYTADKQLDLAFFKLSNFYAIGTPQRTLADHFITTHNAWEQGFAVPLIATMRAGGHTNDPDLNVQGKHEMDAVRLDAAALTRADQASRDAAISHWKTQVRHMETALGLSAVFVGLIIGLYTRVLIHDISEAFKRSNHILRKRAEEAFRAEQRLRTTLASIGDGVITCDPTGLIQTINPVAQELTGWAEAEAHNQPLEHVFRIINETTREPVENPVTKVGRLKTVVGLANHTLLIRKDGTEICIDDSGAPIRDKQGELIGIVLVFRDVTISRKSQAALLANEKLAVAGRLAATIAHEIHNPLDSVSNLLFLMDGESTPAESAAFLQLAKQEVSRVTQISRAMLSLYRESRAPVPIDLKELLESILLLMNGRLANLQVTVTPDLPANLIVQGFPAELRQVFTNLISNAAEAASPSGHVHLTAEPEPAYPTPDSLRTQDGVLITVEDDGPGIDAETRARLFQPFFTTKGEQGTGLGLWVSRGILTKHGATINLASSTDSDDHGTTVTVFLATNPTIQVGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS8</accession>
    <name>E8WYS8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1716</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1716"/>
    <dbReference type="EnsemblBacteria" id="ADW68764">
        <property type="protein sequence ID" value="ADW68764"/>
        <property type="gene ID" value="AciX9_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1716"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066625_0_0_0"/>
    <dbReference type="OMA" id="IYTRCPL"/>
    <dbReference type="OrthoDB" id="1994201at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021647">
        <property type="entry name" value="CusF_Ec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042230">
        <property type="entry name" value="CusF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11604">
        <property type="entry name" value="CusF_Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="151"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="35119" checksum="D09F9D4755EC02A9" modified="2011-04-05" version="1">MRLSSEAGAPGVMGRRYHLCMKNVVVRVFVVALVCLGLGVTGCRKGGGGDAGVASGTKVYSMRGKILEVDPGSGEITVDHKAIPGFMDAMAMPYKLADASTISEMHVGDVITARVLVQDTPGGPYKTQLDHVVVVAQARPDNVPKVQYHSPTAGEEVPDFKLLNQSGKTVHLAQFKGKVLLLTFIYTRCPMADFCPRMSENFAEIDRGLAKDKDVYAKTHLLSVSFDPAYDTPKVLRSYGGAHTGRFTEEDFKHWDFAAPTLAELPKMEEWFDVGVTGAGDPQTLMHSLSTVLIGKDGKVIGWYPQKDWQVGEMEEAVKKAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX5</accession>
    <name>E8WYX5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 9">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_2867</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581205.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2867"/>
    <dbReference type="EnsemblBacteria" id="ADW69890">
        <property type="protein sequence ID" value="ADW69890"/>
        <property type="gene ID" value="AciX9_2867"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2867"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_0"/>
    <dbReference type="OMA" id="QNGWSYE"/>
    <dbReference type="OrthoDB" id="1464088at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="344"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="431" mass="45042" checksum="FE16E4CFA7699B44" modified="2011-04-05" version="1">MTTQNITKIALVGFGTVGSSVAKLLHTLNLPNLRLTHIYNRGIAGKRGSAEAAFVPADAIWTEDIEDLLTSDADVIVELMGGLDPAGPWIERALASGKSVVTANKQLIAYQGPALLAKAAATNVHLLHGAAVAGGVPVIPGITQGLGGDQITRISGILNGTCNFILSKMEAGARYSEVLAEAQSLGYAESDPTADVGGFDARAKLCILARIGMHVELDPEQVATQTIALVDAVDFAYAKELGCTIRQVSRVQLSSTSPDSMYARVAPMLVPRESPIAWSHGTQNMVVTTGRFGGDVVFSGHGAGGEATAVAVLSDLLAVSQNSRPVAFPVTPRPVTGDSVAPHYLRFIVDDKPGIVSAIAGALSKVGANIDSIIQRPGYPKNRLAFVVTTEPCLTSTIAEAVESMGKMDCMLEPPLSLQILVIDDKDEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX7</accession>
    <name>E8WYX7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2869</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581207.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2869"/>
    <dbReference type="EnsemblBacteria" id="ADW69892">
        <property type="protein sequence ID" value="ADW69892"/>
        <property type="gene ID" value="AciX9_2869"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2869"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_0"/>
    <dbReference type="OMA" id="WVTAEVT"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="51"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="48547" checksum="09AACF496F069846" modified="2011-04-05" version="1">MVQAHVSEAIVTAGGIKAGALLVEDGRIVGGCGIDEIPGDVMRVEHGKMALLPGLVDSHVHINEPGRGDWEGFETATQAAAAGGYTTLVDMPLNGLPETTNVPALEAKRAAAEGHCVVDWAAWGGCVADNQGELEGLAAAGVCGFKCFLVYPGCEGFTMVDQAQLEAALPAIARTGLPLLVHAELQGPIDEAAEGLKDKDWRSYSTYLASRPDEAEVAAVRMLIGLCRKYGFRLHIVHLATGLALEMLREAKAEGLPVTVETCPHYLYFSAERVPYGSTVHKCAPPIRSERNRELLWQGLRDGVIDLVATDHSPCPAEMKRMDVGRFDLAWGGIASLSVALPVMFTEAVRRGFGLGDVMRWMGTAPAKLAGLEDRVGSLGAGREATFVVFDMEAEWLIGVNDLYFRHKVSPYLGERVKGRVMETWVRGQRVFEYGAGFAEGRTGRELRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC6</accession>
    <name>E8WZC6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1766</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580133.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1766"/>
    <dbReference type="EnsemblBacteria" id="ADW68814">
        <property type="protein sequence ID" value="ADW68814"/>
        <property type="gene ID" value="AciX9_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1766"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045120_0_1_0"/>
    <dbReference type="OMA" id="WWNGEAI"/>
    <dbReference type="OrthoDB" id="1387983at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="15"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="33944" checksum="6AC1EC2A91B51E13" modified="2011-04-05" version="1">MTFSSLRTSLTEYLFKPVSPWPAAVYRILFGLCVCATLLLLHGDWSNWFGVHGWITPDTIDQAETGFRLNLFALAPHSERWVTALYYLILGASITLTLGLGTRVSSVIVYLGLNALNQRNPIILHGGDTFLRSAAFFLIFASSAEVLSLDSLIRRYRKPSESVPRLISPWPLRLIQYQLALLYLASFWWKAHGNTWWNGTALYYVVNLGEVRRFPIPHILHTAWVLRLGGWCAMAFELLFPCLVWFKRFRNPILIAGLLFHLSLEYALNVPMFQWEVLSAYVLFLNFGERPTQTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL7</accession>
    <name>E8WZL7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="9" type="ordered locus">AciX9_2968</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581305.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2968"/>
    <dbReference type="EnsemblBacteria" id="ADW69991">
        <property type="protein sequence ID" value="ADW69991"/>
        <property type="gene ID" value="AciX9_2968"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2968"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_0"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="8">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="7">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="7">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="7">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="7">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="7">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="39225" checksum="FD79AB7FCC5BC11B" modified="2011-04-05" version="1">MAFRSGFVSIIGRPNAGKSTLLNALLGQKLAIVTHKPQTTRTRIHGVLEVPAKKKTKVGAIETAGHPAAQIVLVDTPGIHKPDTQLDKRMMQEVHDALESRNAVLFIVDVTHRLPVAEVPGEKPKITGRMTLSAAEDDFSLQLVKKLDCPVILLLNKIDQISPAEIMPLIAHWSGLYKFAEIIPVSARKKINLDLLLDKVVAHLPEGQRYFPKEQLTDQPERFLVAELIREKILLLTGEEVPYSTAVVIERFEEPKSLKKLADGRLPVTKIAAAIFCERTGQKAILIGKQGAMLKEIGSAARKDIEGLLGTRVFLELFVKVQEEWRSKPGFIEDLDWRRQMEELAKKQAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT6</accession>
    <name>E8WZT6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0677</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579075.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0677"/>
    <dbReference type="EnsemblBacteria" id="ADW67747">
        <property type="protein sequence ID" value="ADW67747"/>
        <property type="gene ID" value="AciX9_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0677"/>
    <dbReference type="eggNOG" id="ENOG5030VSX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081548_0_0_0"/>
    <dbReference type="OMA" id="GDMVAQR"/>
    <dbReference type="OrthoDB" id="1435450at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="31808" checksum="FA2E204ED8B751FA" modified="2011-04-05" version="1">MKGLLLALVLVGTGRGAVAQQGAQEMKSAAPASRPGETQEQKGKRLLDEMLKALGGDAWLNRGTVYDEGQVASFFRGQPTGAVTRFEEWKRLETAGSPEVTRIEFLTIKGMIKPGMKRDVAHLWTADQGVELTYKGKTLLPKPQVEDYMRRRGHTLDAVMKDLIKQPGVIVIAEGIGMRDRLPVDKVTVLTANNDAVTLELDQHSHLPVQRAFEWRNEQFKDHDIDEEVYGDWRYYQGIATPMNMTRYRNGDMVDQTFYVKVKYGEPMGAELFDPEKPLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV3</accession>
    <name>E8WZV3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0694</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579092.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0694"/>
    <dbReference type="EnsemblBacteria" id="ADW67764">
        <property type="protein sequence ID" value="ADW67764"/>
        <property type="gene ID" value="AciX9_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0694"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="LGEIFMW"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114682" checksum="3A0D168A28940229" modified="2011-04-05" version="1">MIRKLVDFALNNRFLILVMAFFLFGWGAISFHNLPVEAYPDVANNYVTVITQWPGRASEEVEQQVTVPLEIAFAGIPHMSHLRSASLAGLSSVTMVFDDDSENDWNREKVLERLSQVTLPTGLQPQIGTDWSPVGQIFWYTLESSDPKYDTMALKSLEDWTLEKNFRSVPGVVDVSSFGGITREYQVILDPEKLVSYGLSISQVKQQIAANNVNAGGSFIEQGAQQINVREIGLFTSTHDIGNTVLKAQNGTALKVSDIATVVQGPKIRLGQIGKTIRRVDGKLADNSDAIEGVLLLQKGANSDETLEAIHAKVKELNERVLPKGVKVVAFLDRSNLLELTTHTVMHNLTEGIVLVVVILFVFLGNLRGALIVALTIPFALLFASICLDLRHIPANLLSLGALDFGMVVDGAVVMIENIVRHLSHSRKKDMTVTEQIREAAHEVQRPVFYAIGIIITAYLPIFTLQSVEGRLFKPMSWTVAFALLGALIFSMLLAPVLASFLFRNGATEWENPILRWLTNRYRHAATFAIEHRAITFSVAGLALLTSILMVTTGVIGSEFLPHLDEGAIWVRGTLAPSTGPTESLAVANRARIILASFPEVKQVVSQIGRPDDGTDTTGFFNTEYYVDLKQKQDWRPVFKENKEELISAINRQLDVIPGVIWNFSQPISDNVEEAVSGVKGELAVKIYGDDLKTLEQKGDAIVNVMSTIRGVQDLGLFRVIGQPNLNFVVDRDAAARFGINVADIQDAIESAVGGNAVTQVLDGEARYDVTVRYNPQFRATPESIENIRLVSPSGERVSLAQVTKLKTEDGAEEITRENGQRYVAIKYSVRNRDLGSTVQEAIDKVSKQVPLPPGYKTDWAGEYESQKRSSRRLLIVLPITLGLIFMILYSMFGSFKWAALILCNLAMAPIGGLLALLVTRTHFSVSSGVGFLALFGVSVQTGIIMLEYINQMRVAGHSVESAAIEGAVLRLRPILMTMLVATLGLLPAALSHGIGSDSQRPFAIVIVGGLVGALLISVFLLPTLYVWIARDTDVLPIRDEEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ0</accession>
    <name>E8WZZ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1839</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580205.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1839"/>
    <dbReference type="EnsemblBacteria" id="ADW68886">
        <property type="protein sequence ID" value="ADW68886"/>
        <property type="gene ID" value="AciX9_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1839"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="36971" checksum="D171C02500F20EC4" modified="2011-04-05" version="1">MNIKAVAKRANVSTATVSRTINGSDKVSPETAARVHQAIGDLNFIPNTNARALGSGRSNLLGLIISDITNPFFPELVKAFEDIAIGEGHEVLIANTNYDPHRTMHCVTRMIQRKVDGVAIMTSEMDEHLIDFFRRSQIPVVFLDLGTPRPGISCIHIDYSAGVEMAMSHLVGLGHKRIAFISGPMSLASAHTRYRAFMESSARDHLNADPDLVQEGNHRPDGGYEAMKRILASKNRPTAVLASNDLTAIGALGAIFEHGLRVPQDISIIGFDDIQLSAYTTPPLTTVHVPHGEIAKVAVHALLSTKQETGKKLLQGEQHHIRATFLQRHSTGPVPKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G5</accession>
    <name>E8X0G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579155.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0760"/>
    <dbReference type="EnsemblBacteria" id="ADW67829">
        <property type="protein sequence ID" value="ADW67829"/>
        <property type="gene ID" value="AciX9_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0760"/>
    <dbReference type="eggNOG" id="ENOG502Z8GS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053531_0_0_0"/>
    <dbReference type="OMA" id="RAMHAIS"/>
    <dbReference type="OrthoDB" id="1108096at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230134" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="332" mass="34958" checksum="DA8B34FBEF7FCC67" modified="2011-04-05" version="1">MSSKQALSILLLSLSAPFGIAQQVSGPQPQSAGIVGTATDTDGGLIPGATVTIDGPTPEDHHTAIADASGVFTFTDLHPAVAYHLMVTAKGFAAWNSPEEILTPGEERDLKNIPLAVGVVETSVSAITIEQLATEQVKIDEKQRVFGVIPNFYVEYDHQFAPLSTKLKYQLAFKASTDAFTFAAAAFLAGIDQAADTPAYVEGAKGYGQRFGAVYAQGASGILIGGAILPSLLHQDPRYFYQGTGTKKSRALHAASAPFIARGDNGRWQFNYSSIGGDLASSALTNIYYPPTNRGAGLVFGNAAVATGGRVANALLQEFVLHKVTHGPKRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I0</accession>
    <name>E8X0I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0775</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579170.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0775"/>
    <dbReference type="EnsemblBacteria" id="ADW67844">
        <property type="protein sequence ID" value="ADW67844"/>
        <property type="gene ID" value="AciX9_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0775"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054524_0_1_0"/>
    <dbReference type="OMA" id="NALKWSD"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="361" mass="38291" checksum="F00A7AA0C728D4FF" modified="2011-04-05" version="1">MPSQQEVRWSQLKIGVIVLVAAVILVTLLFLMTSSSGLGVLSKKLTVSVYFENAAGIKEGAAVNLQGVTIGAVKSVSVTADPARKLTPVRVVMKLDSKYQSELKEDSTAALTTVGVLGDTVVDINSQVAHGAPLKDGDELHTLETPSITDVVKASQGTIEQLNVILAKMNTIVDNLQSGKGSVGQLINNPDLYNKANATVEELHTLEVNLNNGKGSIGKLVTDDTMYNRLNDAAGKLDQIATSLQGGHGTAGKLLYDETLYNNLNATLTKTNALLGDVQNGKGAAGMLINDPAFAQQLRDTLSNTNAIVAGVNQGKGTLGKLANDDQAYTNLNKLLTESTLLVTTIRQDPKKYLTIHLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S5</accession>
    <name>E8X0S5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69026">
        <property type="protein sequence ID" value="ADW69026"/>
        <property type="gene ID" value="AciX9_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1980"/>
    <dbReference type="HOGENOM" id="CLU_3403798_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="30" mass="3197" checksum="18AE52B5EECDFEF0" modified="2011-04-05" version="1">MDYAALLVNVAQLTVAIIALAVSIVALRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y9</accession>
    <name>E8X0Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3162</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581486.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3162"/>
    <dbReference type="EnsemblBacteria" id="ADW70173">
        <property type="protein sequence ID" value="ADW70173"/>
        <property type="gene ID" value="AciX9_3162"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3162"/>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="OMA" id="HIADIVP"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="28696" checksum="6CEA7A66B5F69FC8" modified="2011-04-05" version="1">MTSSKSFLKLEHVSVARGATIVLHDISLRVAPGEHIAILGPNGCGKSTLIKLMTCELYPIVLPGASVEIFGPSRWNVAELRRRLGVVTCETPPKSALDTSAMDVVLTGFFSSSTLWPNLTVTADMRSAAAEALEYVGGTYLADRPLGQLSAGQQKRVVIARALVGSGTSEGDRVLLLDEPSNALDLAAQAELRLTMRNLAKTGTGIILVTHHIADIVPEINRVLMMREGHLIADGPREVMLTEEKLSGLFETPVNLSYRDGYLHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z5</accession>
    <name>E8X0Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581491.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3168"/>
    <dbReference type="EnsemblBacteria" id="ADW70179">
        <property type="protein sequence ID" value="ADW70179"/>
        <property type="gene ID" value="AciX9_3168"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3168"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098597_0_0_0"/>
    <dbReference type="OMA" id="DLRGNKQ"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="215" mass="24056" checksum="CAA8790D3C52CA53" modified="2011-04-05" version="1">MGNRFHELAFTDVVKAHQQEHGSRRQYERMAQGGATGGSLGISEETFLSMRDSFYMASVSETGWPYIQHRGGAAGFVKVLAPELIAFADLRGNKQYISLGNLEHDARVALFFMDYPNQTRLKILGRVEIHESDSESATLIKRLRPADPKDIPERAILIHVEGFDWNCPQHITPRYTVEELQPALRPLQDRLAALEAENAGLRATIKTAAASRNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X178</accession>
    <name>E8X178_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1986</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1986"/>
    <dbReference type="EnsemblBacteria" id="ADW69032">
        <property type="protein sequence ID" value="ADW69032"/>
        <property type="gene ID" value="AciX9_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1986"/>
    <dbReference type="HOGENOM" id="CLU_2752160_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="8055" checksum="F0B725520DFA15DA" modified="2011-04-05" version="1">MFDPFANTPRINRTMVYLGACMIAGIRLARERQVNVRVVPTRVAVDESVELAHEIFNKVFRRVPEKLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C6</accession>
    <name>E8X1C6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">AciX9_2035</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580397.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2035"/>
    <dbReference type="EnsemblBacteria" id="ADW69080">
        <property type="protein sequence ID" value="ADW69080"/>
        <property type="gene ID" value="AciX9_2035"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2035"/>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094161_0_1_0"/>
    <dbReference type="OMA" id="DCLTVWL"/>
    <dbReference type="OrthoDB" id="1903913at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ADW69080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="19610" checksum="6B049DF0715E8FAA" modified="2011-04-05" version="1">MHDTPKPPVTLILGGARSGKSHHAQKLAALSDRVLFIATATAVDPEMSEKITRHRQDRQRDRLDWTVLEEPLALAEAIHTHGPAHDVILIDCLTLYTANLLTIPPAAVTENVALFLETLQAPPRPIILVSNEVGSGVVPSYASGRQYRDLLGELNQRVAAIATGVLLMVAGLPLTIKARQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q0</accession>
    <name>E8X1Q0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0902</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579293.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0902"/>
    <dbReference type="EnsemblBacteria" id="ADW67969">
        <property type="protein sequence ID" value="ADW67969"/>
        <property type="gene ID" value="AciX9_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0902"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_0"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CofH_C" evidence="2">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="34251" checksum="36D843305CB3798C" modified="2011-04-05" version="1">MGITAAQALDCFRSDDLIGIGMEADAVRRTLHPEGVVSYLIDRRIELKPTEDLLPALLNQARQAADTGATGLTLIDASPLGLPLETLEYLLTALRQHHPHLWLHGLDATKLLTLPEASDLPLLLTRLKDAGLDSITGEDAAILDDEAREILKSPLCESAEWLNFHRTAHQLGLRSSASMLFGFGETSEQRVAHLEALRTLQAETGGFSSFSLAAHLPTPQQRQQGLEEPTSVESLKTLAIARMVLDNIENIQTEASAHGLKVLQMALRFGSNDAGSVMSATGLGATEEELRRLIRDAGFRPVQRDTPYHTLFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q2</accession>
    <name>E8X1Q2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0904</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0904"/>
    <dbReference type="REBASE" id="32574">
        <property type="entry name" value="M.AspMP5ORF904P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67971">
        <property type="protein sequence ID" value="ADW67971"/>
        <property type="gene ID" value="AciX9_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0904"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_10_4_0"/>
    <dbReference type="OMA" id="WPTKHDN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="34630" checksum="AB038657DEA8809D" modified="2011-04-05" version="1">MNRIVLGENLAVLKTLPAHSADLIYIDPPFNTGKTQFRRRMKTVTDAEGDRTGFGGRRFRTEILDDGLAGYLDSFDDYIGFLRPRMIEARRILTPTGSLFLHVDPREVHYCKVMLDEVFGRPCFQNEIIWAYDYGARTSKRWPAKHDNLLWYTRDPKRFTFDLNATDRIPYMAPRLVGAAKTARGKTPTDVWWHTIVSPTGKEKTGYATQKPVNMLERIVRVHSRPGDRVLDFFAGSGTTGEAAQRNDRSFLLIDQSPEAIKVMEKRLNLKAEKAERTHTRKRTAAKAVAKPPIRPKAEPKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q5</accession>
    <name>E8X1Q5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0907</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579298.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0907"/>
    <dbReference type="EnsemblBacteria" id="ADW67974">
        <property type="protein sequence ID" value="ADW67974"/>
        <property type="gene ID" value="AciX9_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0907"/>
    <dbReference type="eggNOG" id="ENOG502ZN72">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2508070_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9312" checksum="18A7B7DFE849C5C3" modified="2011-04-05" version="1">MTAEDIEVLKESVDRVLAIELVAGEQFFAEIVMVVDEPPTPDVFVLRVLREPDGVFVATSNTGESFLLADISRVARIPGVDYSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R7</accession>
    <name>E8X1R7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">AciX9_0919</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579310.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0919"/>
    <dbReference type="EnsemblBacteria" id="ADW67986">
        <property type="protein sequence ID" value="ADW67986"/>
        <property type="gene ID" value="AciX9_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0919"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="5851" checksum="A3F5B40F8BCF41AB" modified="2011-04-05" version="1">MREIITLQCPECKNRNYSTTKNKKTTTGRLEFSKFCNTCRKHTDHKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y0</accession>
    <name>E8X1Y0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2097</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580457.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2097"/>
    <dbReference type="EnsemblBacteria" id="ADW69141">
        <property type="protein sequence ID" value="ADW69141"/>
        <property type="gene ID" value="AciX9_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2097"/>
    <dbReference type="eggNOG" id="COG1648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_1_0"/>
    <dbReference type="OMA" id="STQIWKL"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="23881" checksum="872B96919D85B673" modified="2011-04-05" version="1">MDLFPIFLKLAARPCIVIGAGNLAESKIESLRAAHARVTVIAPSARESIQNMDAAGEITWLQRVYRPGDLAGNFLVVAATDNPAVNRAVFAEAEASDILCNAVDDPPFCDFYFPSVVRRGDLQIAISTAGASPALAQRLRKEINAQLPLDLGDWLTDLGDLRREVVAAEPLNEDRKLLLHQLAQRDVCGYDACPSRAMARRHAQTNPAPLITEIPDATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z4</accession>
    <name>E8X1Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2111</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580471.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2111"/>
    <dbReference type="EnsemblBacteria" id="ADW69155">
        <property type="protein sequence ID" value="ADW69155"/>
        <property type="gene ID" value="AciX9_2111"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2111"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_0"/>
    <dbReference type="OMA" id="GSIVIHQ"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="41068" checksum="42F2BEF80AABB869" modified="2011-04-05" version="1">MRKPLLALAVSAFAIGTSEFIIMGLLPDLAHSFQVSIPKAGILISGYALSVTLGSPFLALALARLDRKRALLILMGVFIAGNILCALAPTYSLLLVARILTALCHGAFFGAGSIVAANLVPKSERAQAIALMFSGLTIANVLGVPAGTALGQWLGWRFAFWALVPIGVIAAIGLWKMVPSQPAEIIHLKHEFHAVLRPQVQLVLTLSTLSSVALFCVFAYIAPILEAVTHLPPHIVSWVLVVFGVGITLGNLIGGRLSDWKPMGVILGGMATLIVLFLLMPLTQPHAAAEIAMVFVWGFVHFGAGAPLQARIVDRAKGAPNLASTLNQGAFNLGNALGAAMGGLMLTYGLSYQRLPLGAAAVCCLALAVALVALKLERNEARDALGAEVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X287</accession>
    <name>E8X287_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0952</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0952"/>
    <dbReference type="EnsemblBacteria" id="ADW68019">
        <property type="protein sequence ID" value="ADW68019"/>
        <property type="gene ID" value="AciX9_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0952"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="14228" checksum="A932CDC4AA99A99E" modified="2011-04-05" version="1">MPLKSKSSTTISPTQERSKGRIPPTHPGEMLREEFLIPLKLSANALAMAIRVPATRVSEIVNERRGITADTALRLARYFHMTPEFWMNLQTHYDLECARDASDTIIQQDVRPAPIDKKTGALRSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M8</accession>
    <name>E8X2M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581637.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3314"/>
    <dbReference type="EnsemblBacteria" id="ADW70325">
        <property type="protein sequence ID" value="ADW70325"/>
        <property type="gene ID" value="AciX9_3314"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3314"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_0"/>
    <dbReference type="OMA" id="GWIRAEW"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017799">
        <property type="entry name" value="Tscrpt_reg_PadR_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03433">
        <property type="entry name" value="padR_acidobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="12227" checksum="BD0277AF6AA0AC1B" modified="2011-04-05" version="1">MAKNDLQGTLDLLVLKTLSQMGALHGYGIVVHIQRASEELLRVEEGSLYPALHRMEQSGWIRSEWGLTATNRKAKYYKLTPAGKTQLREAEKSFEHLVKGVRAIMQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N5</accession>
    <name>E8X2N5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3323</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3323"/>
    <dbReference type="EnsemblBacteria" id="ADW70332">
        <property type="protein sequence ID" value="ADW70332"/>
        <property type="gene ID" value="AciX9_3323"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3323"/>
    <dbReference type="HOGENOM" id="CLU_2770115_0_0_0"/>
    <dbReference type="OrthoDB" id="1937825at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="8159" checksum="BA70CC6C9A766FC1" modified="2011-04-05" version="1">MQMITWEECHFELRARLVKELGPEMRRSSPGLRITDEELDGMIDPIITREMVNAIFTAHSRNRFCRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T4</accession>
    <name>E8X2T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3373</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581693.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3373"/>
    <dbReference type="EnsemblBacteria" id="ADW70381">
        <property type="protein sequence ID" value="ADW70381"/>
        <property type="gene ID" value="AciX9_3373"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3373"/>
    <dbReference type="eggNOG" id="ENOG503411G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157872_0_0_0"/>
    <dbReference type="OrthoDB" id="1984600at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11259" checksum="903CFD5AAAEFE448" modified="2011-04-05" version="1">MAVEREKIYDCEVKRRRMKEGGGYEPFWKVKSVADALADADTEFRCKDCGGAVKLLGKNSKTGGAPYVEHKDPLDSAYCFGGIIFKKATDGREAKQSAHPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y6</accession>
    <name>E8X2Y6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1057"/>
    <dbReference type="EnsemblBacteria" id="ADW68120">
        <property type="protein sequence ID" value="ADW68120"/>
        <property type="gene ID" value="AciX9_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1057"/>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119034_1_0_0"/>
    <dbReference type="OMA" id="GWLVMAP"/>
    <dbReference type="OrthoDB" id="1973782at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="20796" checksum="795AA1FC89E169C6" modified="2011-04-05" version="1">MKSPGIATPFDHLSLSLPQSRMAASLTASISLLFQRHIISPVMHLLRVGASPRRLAWSLAVGVAVGINPLLGSTTLLCLAVAFVLRLNLVASQISNHLVYPLQLALFFVFIDIGDRIFHTGKLPLDREALLSAMRHHPLATTRMLWSWEWHALIVWTLFSAALIPLVALILRPALERLLLKLHTETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X302</accession>
    <name>E8X302_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1073</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1073"/>
    <dbReference type="EnsemblBacteria" id="ADW68136">
        <property type="protein sequence ID" value="ADW68136"/>
        <property type="gene ID" value="AciX9_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1073"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_5_2_0"/>
    <dbReference type="OMA" id="MENIRDP"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="201"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="5">
        <location>
            <begin position="408"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="701" mass="75058" checksum="9AB5253668410CC7" modified="2011-04-05" version="1">MGGVDTGDMDELLSAGEELIGEFLAESREGLDRMELCLTELEVRPGDGELVGEIFRAVHNIKGTVGFLGFGRLERLAHAGETLLGSLRDGRVRADEELISGLLRLLDGLREILGLIEATGAEGADGDLVLIAELTALNESGAAAEGVGARRGVEVFGAAEKTLRVDVEVLDRMMNLVGELVLTRNQIVQRPCEGEGFGVLARRLDSVTAELRESVMRARMQPVGHVFGKFSRLVRELGRTCGKKVRIEFAGLETGLDKSLLEAIKDPLTHAVRNAVDHGIEGPAERVAAGKAAEGVIRLEAYQEGGAVVIELSDDGAGMCRRRLIGKALERGLISEEQVAGMGDEDALQLIFLPGFSTAAEVTTVSGRGVGMDVVRANVEKAGGTVEVESREGWGTVLRMRVPLTLAIVPALVVRSGGQSLCLPQSAVMELVYVSSMQAARGIERMGGAQLYRLRDELLPLVWLDEVMRVPQQRQAHGFYVAVLETDGRRYGLAVDELTTPEEIVVKPLSAVLRDVGLFSGATVLGNGMLAMILDVGAVAVRAGVKGMGKVTLAAVAEAMPMAEFLVFEQVVQGRMERGAMPLGLVERIERIRVAEVEYIGGRAVMQYRGDLMGLEDEGGLRDGEMATVLVCRRPDGSGRRYGLVVARVLDVTRGEPVPGGEPGLVLVKGRLASVHEDKAGLVPDGLLEMRGLREFGRNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X306</accession>
    <name>E8X306_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCP methyltransferase, CheR-type</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1077</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579463.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1077"/>
    <dbReference type="EnsemblBacteria" id="ADW68140">
        <property type="protein sequence ID" value="ADW68140"/>
        <property type="gene ID" value="AciX9_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1077"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_2_0"/>
    <dbReference type="OMA" id="EWQEFVN"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="31251" checksum="4F1812A385F516D4" modified="2011-04-05" version="1">MAVSELDYKFLRDVVLTQSANLIEPSRNALFDTKLTPIARMAGAANLEALVGMLRVDRTTQLHQAVAEAMTINETSFFRDARPFEALRTEILPRLIEQKEGERRLRIWSAASSTGQEAYSLAMLLCEHFPELGRWDVRIVGTDISRQVVDYAEAGRYRRLEVNRGLPARMLVKYFERQGDEWQISEKIRAMCEFKCVNLCAPLLKLPVFDLVLLRNVLLYFPSAGRSAVFEGVYRQMTPGGYLLLGNAEQAEDSTELFGVEFASECYFYRPVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X378</accession>
    <name>E8X378_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2264</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580618.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2264"/>
    <dbReference type="EnsemblBacteria" id="ADW69302">
        <property type="protein sequence ID" value="ADW69302"/>
        <property type="gene ID" value="AciX9_2264"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2264"/>
    <dbReference type="eggNOG" id="COG3678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149264_0_0_0"/>
    <dbReference type="OrthoDB" id="2028312at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234314" evidence="2">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="15965" checksum="E9E2F07F1B858AAF" modified="2011-04-05" version="1">MRTLSQLSFILLGAALCGGVAASAQTPDQTAPAPAPIVREHAHHGPDAAHQVKFLTKKLGLTPDQAAQVEPILAERDQKMADLHASDSNMTVKQMHQQMRAIMEDSKQKLDGVLNDQQKQQLAEMKSERRHHGRGGDQGAAAPAPAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D5</accession>
    <name>E8X3D5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3430"/>
    <dbReference type="EnsemblBacteria" id="ADW70436">
        <property type="protein sequence ID" value="ADW70436"/>
        <property type="gene ID" value="AciX9_3430"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3430"/>
    <dbReference type="HOGENOM" id="CLU_3200396_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="45" mass="5386" checksum="F2DB4761C9CEAE60" modified="2011-04-05" version="1">MVVGTFLLWRYFELLFHRFTLVPAIQNETFFVRKAIWTALEPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G1</accession>
    <name>E8X3G1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ordered locus">AciX9_3457</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581773.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3457"/>
    <dbReference type="EnsemblBacteria" id="ADW70462">
        <property type="protein sequence ID" value="ADW70462"/>
        <property type="gene ID" value="AciX9_3457"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3457"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_0"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="62" mass="6891" checksum="34BA531C9C9193E4" modified="2011-04-05" version="1">MPNPKRRHSKQRTAKRRSHDFLTPVNSGACPNCGERKLSHRACPKCGEYKGRAVLAKAETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R1</accession>
    <name>E8X3R1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2302</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580655.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2302"/>
    <dbReference type="EnsemblBacteria" id="ADW69339">
        <property type="protein sequence ID" value="ADW69339"/>
        <property type="gene ID" value="AciX9_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2302"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_4_0"/>
    <dbReference type="OMA" id="IFWAFNI"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="347"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="447" mass="47613" checksum="BA74C84F9309F511" modified="2011-04-05" version="1">MFFRLLWESFVRQRRRKALAAIAILLGTTAVTAMLALATTIGDRIHRELAVYGANIVVYPKADTLSVNVGGVDLKPSTGGAYLKEADLEKLKTIFWANNITGLSPELRMSRIALGSDGKVLKPVTAVGYWFNHRFGNITTGAPQLHPWWKLEGKWPVEALAKGKHREDAVQVVLGSKLAQQLGMHIGDDFVLAIEQPGYAPEADVVGIVTTGDATDNEVLLPLSIPISQVVVAGKATAPPVSNSDLSRVEISATTKPEDAFARKDPDTLSPAQHEIWYCRPYANSIAYQIREAIPGAAAEQVRRVEQSEGTVLSRISGLMWLVSGAALLAAGFAVSAAMATAVLERRREIGLMRSLGASKGSIALLFYSETGLLAVVAGSLGYVAGSVLAYWLGGHIFSGDANGPVLNLVLLPVVVAMALIVAVAGSTPSIRTALRMDPSMVLRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S2</accession>
    <name>E8X3S2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580666.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2313"/>
    <dbReference type="EnsemblBacteria" id="ADW69350">
        <property type="protein sequence ID" value="ADW69350"/>
        <property type="gene ID" value="AciX9_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2313"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298326_0_0_0"/>
    <dbReference type="OMA" id="HCADRRL"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="69"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23278" checksum="1D906EB9ECDEC076" modified="2011-04-05" version="1">MEGEFKADRRNFLASAVTVAGSALAAGLGQSEAFCEEAAGQVHPAAGSSLSFDHLYDSSVLATTLKGEAADRLALRRLVDAWAHCADRRLAEQQANLFVPDGAIVNYEGDPRTHKPHSTIKGRAAIQSALAVLNSFTVTLHMNGQSDALIQGDRAIGENYCIVHQFTEANGQRKCQTLGIRYYDQFLRQESRWLFVERKVVIDWSDSRLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T5</accession>
    <name>E8X3T5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2326</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580679.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2326"/>
    <dbReference type="EnsemblBacteria" id="ADW69363">
        <property type="protein sequence ID" value="ADW69363"/>
        <property type="gene ID" value="AciX9_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2326"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064918_0_0_0"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="109"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="364" mass="40545" checksum="FA3D09F95FE7B42C" modified="2011-04-05" version="1">MAQTQTPAYNPALNGIPQSPSGRPYPNGNPADSLNPAAAKNTDSCMPLHPTGPVIHNYHCEGSAPGTLGFRWIFGSVIAARNKDPRIQVMQYNEDTYLMRENICVNWEGPFTYLLFGNKGALLIDTGATPQAEWYPLRKTVDDIITRWARARGRSNVPLTVVMTSGEDIAQNQGLAQFAGRPNTTLVPKPLHEMKAFYKLNASWRKGIGKIDLGDRVIDVLATPGTHKDGVSFYDPYCDFLFTGDLLYPGKIQISNDKDFVASLERLKQWKDTHPVKWVLGGHVEMQFLPGKAYPRFYTYKPYERLLPMEPPLIDEALAAAKEIVGKETVLVRVDFQLLNRVSPDQKTLDFPAGVPNITGPRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V5</accession>
    <name>E8X3V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2346</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2346"/>
    <dbReference type="EnsemblBacteria" id="ADW69383">
        <property type="protein sequence ID" value="ADW69383"/>
        <property type="gene ID" value="AciX9_2346"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2346"/>
    <dbReference type="eggNOG" id="ENOG5033IX1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592249_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="17233" checksum="6FEBDA55797F2BF2" modified="2011-04-05" version="1">MKSVLVGLLVCSAGSCFGSELPRGCFRSVAEAVSQTVGAPLVASGGYRLADVRRDALRNKSWAMVESCGHPEQPAIAVEVAGSVLKGESAAGVAVGPVVMRAGATVRLVRLEANVRLEMPAVAQMNGALGERVRVRVVRSVGDFGGAGSEEQVLVGVVRGSDVLEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X480</accession>
    <name>E8X480_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0049</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578469.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0049"/>
    <dbReference type="EnsemblBacteria" id="ADW67140">
        <property type="protein sequence ID" value="ADW67140"/>
        <property type="gene ID" value="AciX9_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0049"/>
    <dbReference type="eggNOG" id="ENOG5034CGX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491566_0_0_0"/>
    <dbReference type="OrthoDB" id="2215599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="554" mass="61355" checksum="D2313CC7F9ABDAD4" modified="2011-04-05" version="1">MLALSFAVPLLVLCAYWFFFIRADYYPSRDEFSLLVASTKMFHPAISTWFLEGYSRYFLSYPGLSHPATDFIRPGANLAYYVNSLLFGANWSCYLLLSYFIQAGLVCITVKLALEALKLPRSLAVFAGVAVLLAPSFGWEQIYIPSFTIDLLGAFFVMLALHELWRSRNVTAWLLLAAAIFTKETTLFAPVMTALAVWLPIGKPSSIGRRFTASILWLTPIFVWMLLRHFAFHGGAGIYVFQNMALKGTLMNVLHGFLAWPFGTRSMQQSVRYRSLFFMLNAAFWAAVFFAVVRWRRGKASSEASSEITCMPALLLFSIGAMAMPVLLNLPQRFGASLYPLLFLTLATIAHAASDLTIRRLAVGALAASTLVAIYQKATDPLTLKESRAEWTLSRNYIQSIHAVRSPYLLLVDDSSGGFAAPDLVARFADFHGTLMRSNNIEGLMLDHCAGQPTVTKTSADEGHLALTSTLTPPCGYYAFDSLSPRELERGTDGLVTHPNDRVTLRIVPPALQPLPPSATPEMWGNLTVSLTSPVKDTVVLVPDLNTLTYHQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X490</accession>
    <name>E8X490_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0059</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578479.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0059"/>
    <dbReference type="EnsemblBacteria" id="ADW67150">
        <property type="protein sequence ID" value="ADW67150"/>
        <property type="gene ID" value="AciX9_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0059"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_1_0_0"/>
    <dbReference type="OMA" id="IGLMDPA"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="356" mass="39583" checksum="27ECF949C82EDDB2" modified="2011-04-05" version="1">MTSNLQGGPPAELIFGEWYPAGRSAGLKKGKTTTALLCGVPLLLGRKNDGTVFAMRDLCPHRGIPLSAGWFDGNEVQCKYHGWKFEPCSGQCTEIPSLTGLDILQPTKIYATSYPCEERDGTCWVYLPEAGAGRRTAELPPVPEVPKFSAKFRSAHLTADLPCNVDHGIIGLMDPAHGPFVHQAWWWRSRASIHEKTKHFEPIPGGFRISSHAPSANSAPYKLLGVYGEPITTTIDFVLPNRRYETIRAGEKWFASLTTVTPVTASTCRIDVYAAWNVFYNVPLVKTIATFFGARFVRQDQETMIEQAQGLRFRPALMLIDDADQPAKWYFALKQARLTGIGEHPLKGPVELHWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X498</accession>
    <name>E8X498_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S-cluster-containing hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0067"/>
    <dbReference type="EnsemblBacteria" id="ADW67158">
        <property type="protein sequence ID" value="ADW67158"/>
        <property type="gene ID" value="AciX9_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0067"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306470_0_0_0"/>
    <dbReference type="OMA" id="SRDMHWL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030948">
        <property type="entry name" value="MoCo_extend_TAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04519">
        <property type="entry name" value="MoCo_extend_TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="839"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="894"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116389" checksum="81C8E19ACE4945A4" modified="2011-04-05" version="1">MSNGMEPLEIMANTESMEAHQGSSVATEAVQVVTSITPAPAAKMTLAAVQAKLAGQTGKRFWKNLEELSATQEFNDMLGEEFPRQAGEWTDAVSRRGFLKVMGASFALAGLSGCTKQPDEPIYPYVKQPEDLVLGRPMYFATAHPFPTGAIPVLVKSDAFRPIKIEGNPDHPMSKGKSDAYTQATLLDLYDPDRSHTVRFRGQDGEFGKFQDSLLKAVKASQGQGVYFLSETITSPTLATQWKSVQAAYPGTKLIQWEPINQDSSRAASKAAFGSYTDAQYKLEDADVILSLDADFLGGIAHPGFLPLASAYAERHRFEKDKTMNRLYVVESMPTVTGFKAEHRLALKPSEIAVFAEALASGGSGSFSNPDASVFLTKLLADLKASGGKGVVIPGEGASAAVHAAAYKLNASLGAVGKTVIYTETVNPLPTEQLADLKSLVADMNAGKVQFLVLLGVNPLYTAPKDLNFADALGKVTTTASLSTHVDETASITTWHINKTHYLESWTDARTYDGTITVIQPMIAPLYDGKSSHDIIQGLLENPQNSAYDAVVANAKTYIKGDFPTAWRKTLHDGWVEGTAFAATSKTPSAGTATPSAPATATAGLEIAFKHDPSIYDGRYANVGWLQELPKQVTSLSWDNAALVSLNTQQKLGIAENDAVEIELNGRKVVAPILMVPGHPDDVVTVYLGHGRSEAGRVGSGVGFDAYTLRTSDAPLVAFGAQITRGKGTYDLCVTKVHSIEHRGTYAQHDLEQSLDDKKGTYSLPGHEAEERGIIRYATVTEAKANPDFAHDGNVSGTKVNKVGYGPEGEKPEHDNSFFPDAWKYDHPDQSTLRVQNAWGMSIDLNSCIGCNACIVSCYAENNIPVVGREQVKVGRNMQWLRIDTYFEGDLHAPKAHFQPMACQHCENAGCEQVCPVGATVHTPEGINTMVYNRCVGTRYCSNNCPYKVRRFNFLLYSDYDTESLKFMRNPDVSVRSRGVMEKCSYCIQRIEAVKIEADKDNRAIKDGDIVTACQQACPTDAIIFGNQNDPTSKVAKRKAEERDYQVLADLNFRPRTSYMAGVINPNPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B1</accession>
    <name>E8X4B1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="7" type="ordered locus">AciX9_1175</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1175"/>
    <dbReference type="EnsemblBacteria" id="ADW68238">
        <property type="protein sequence ID" value="ADW68238"/>
        <property type="gene ID" value="AciX9_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1175"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072492_2_0_0"/>
    <dbReference type="OMA" id="VSIFMSP"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023566185" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023566184" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26019" checksum="E8325EC3FD29C628" modified="2011-04-05" version="1">MGFERAHAVGGMTLSVAGATYNWQTMVRDGFFYGLGLAIVAAALWATTHSWFLIVPAVILACFFLWFFRDPNRTIPAGEGLIVSPADGVVTEAEWVETTAGGKLRVSIFLNVFDVHVNRSPISGTVTVVEHRAGGYMNAMAPESVLSNEQTLIQIEGDGYQVSFKQIAGLLARRIVCNLQPGQRIERGQRMGLIKFGSRCDVLMPAEATLKVKTGSRVKGGSTILGAMPAIDSTAAVDLLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G4</accession>
    <name>E8X4G4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579614.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1228"/>
    <dbReference type="EnsemblBacteria" id="ADW68291">
        <property type="protein sequence ID" value="ADW68291"/>
        <property type="gene ID" value="AciX9_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1228"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_0_0"/>
    <dbReference type="OMA" id="NIYAPFW"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="31872" checksum="8ABBB104647E5760" modified="2011-04-05" version="1">MSDLYKLQDPTKQYPQPKFKHQPQSVPGLDKDMTPKADHGETSYKGNGRLPKRKALVTGGDSGIGRAAAIAFAREGADVVINYLPSEEADAKEVIALIEKEGRKAYAMPGDLSDEAFCRKLVKDAHKKLGGLDILACVAGKQHAVEKIKDVTTEQMEATYRVNVFALFWLCQEALPLMPAGGSIITTASIQATHPSPSLLDYAPTKAAILAFTRALARQVAEDGIRVNCVAPGPIWTPLQVSGGQPDKKIPEFGSETPMKRPGQPVELAPLYVLLASQEASYVTGEVYGATGGLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G8</accession>
    <name>E8X4G8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor, CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579618.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1232"/>
    <dbReference type="EnsemblBacteria" id="ADW68295">
        <property type="protein sequence ID" value="ADW68295"/>
        <property type="gene ID" value="AciX9_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1232"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_2_0"/>
    <dbReference type="OMA" id="WEIMRII"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="15329" checksum="FC5C6F21675BF2B8" modified="2011-04-05" version="1">MPPKPSITLTEAELRLMRVLWLRGQSSVSDMVTALEHTTPLAYNSVLTTIRVLETKGYVTHTQEGRAFLYSPSIAQHEASRSEIGHVLQRFFGNSRERLLLSLLGDDEITPEELQRLKQAIANTPDDAAPASEKEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J9</accession>
    <name>E8X4J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2372</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580725.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2372"/>
    <dbReference type="EnsemblBacteria" id="ADW69409">
        <property type="protein sequence ID" value="ADW69409"/>
        <property type="gene ID" value="AciX9_2372"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2372"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_2_0"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="22824" checksum="69E0E46E84983AB1" modified="2011-04-05" version="1">MTAEILRINPDEPEPALVDYIAGRIESGLLVALPTDTFYGLAVDPVNLRAVERIYHLKNRARHKPLSLLIADVAQAYGLARECDTAFDRLAERFWPGPLTIIVKAGSKLPLRVTANTGNVALRVPEAPIARAVVAKLGLPITATSANLEGHAECTSASGVREQLGDKIPLIVDGGPTARTVATTIVDLSGGGNSWTILREGAIPTHEIALCLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S2</accession>
    <name>E8X4S2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ethanolamine ammonia-lyase large subunit</fullName>
            <shortName evidence="1">EAL large subunit</shortName>
            <ecNumber evidence="1">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutB</name>
        <name evidence="2" type="ordered locus">AciX9_3557</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="1">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutB family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581872.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3557"/>
    <dbReference type="EnsemblBacteria" id="ADW70561">
        <property type="protein sequence ID" value="ADW70561"/>
        <property type="gene ID" value="AciX9_3557"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3557"/>
    <dbReference type="eggNOG" id="COG4303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048555_0_0_0"/>
    <dbReference type="OMA" id="EADQNDM"/>
    <dbReference type="OrthoDB" id="230269at2"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00861">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010628">
        <property type="entry name" value="EutB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044939">
        <property type="entry name" value="EutB_dom_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044941">
        <property type="entry name" value="EutB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39329">
        <property type="entry name" value="PTHR39329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06751">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018788">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="47550" checksum="560E114267F3111D" modified="2011-04-05" version="1">MLLRHTVDGVRYTFDGLRELLGKASPARSGDELAGLAAGSAVERVAAQMTLAEVPLRAFLDEAVVPYETDEVTRLIVDGHDAEAFGAVGSLTVGGFRDALLSDEMDGVALAGLSPGLMPEMCAAVSKLMRVQDLIVVARKIRVVTKFRTTVGLPGRMSTRLQPNHPTDDPLGIAAAIVDGLMLGSGDAVIGINPAADDVGSTGRLLRLIDAVRTRYAIPTQSCVLAHVTTQMAALEQGAPVDLMFQSIAGTEAANASFGVNLGLLREANEMALGLGRGGKNVMYFETGQGSALSAGAHHGVDQQTCEARAYAVARVFKPMLVNTVVGFIGPEYLYDGKQIARAGLEDHFCGKLMGLPMGCDVCYTNHAEADQDDMDGLLTLLGVAGVNYVMGVPGADDVMLQYQSTSFHDALYVREALGLKAAPEFEEWLGSDGARRLREPMQAQLVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W9</accession>
    <name>E8X4W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3605</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581919.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3605"/>
    <dbReference type="EnsemblBacteria" id="ADW70608">
        <property type="protein sequence ID" value="ADW70608"/>
        <property type="gene ID" value="AciX9_3605"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3605"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_1_1_0"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="11"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="17631" checksum="65DE7665C70CF60A" modified="2011-04-05" version="1">MDSFSHEMRAVVVTVSDRCAAGTQVDVSGPLVAKMLVEAGMAEPVRVTLPDEVQEIAHALRHHAMQADLIVTTGGTGLAPRDVTPEATRIVCDRLVDGLAERMRAEGLKETARAPLSRGVCGCLDGTLVVNLPGSPRGAETSLRAILDLLPHALALLAGRTGHEGEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y5</accession>
    <name>E8X4Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA methylase N-4/N-6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0087</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578506.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0087"/>
    <dbReference type="REBASE" id="32572">
        <property type="entry name" value="M.AspMP5ORF87P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67177">
        <property type="protein sequence ID" value="ADW67177"/>
        <property type="gene ID" value="AciX9_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0087"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007014_0_0_0"/>
    <dbReference type="OMA" id="MGARYPY"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="935" mass="105280" checksum="671446997EC4822C" modified="2011-04-05" version="1">MAEKKSTGTTAKTVTTLVHDDASRKNIPTAEFQSVMRTEEQRPTRVAYERRNRDLDPQLIWRGKYPGDDMDAEQPLTVPAPPLYIQEKVHPKVLIDDLKRETERQRAAGSGGAQVGQIDLFADFNGLPNMDAKTEFYQHDQHWSNRMILGDSLQVMASLAEREGLRGKVQCIYFDPPYGIKFNSNFQWSTTSRDVKDGNVGHITREPEQVKAFRDTWRDGIHSYLSYLRDRLVAARDMLTDSGSIFVQIGDENSHRVRALLDEVFGPDNAVSEIAFSKTTGLGAKFLSSRFDFLLWYAKDKDQAKFRRPYLSKSHEAGTADTYFWIRNEAGQYRALTRNEKDAMMIPAGYELYKAGDLTSQGNTPIDFTFQAADYTLRSKTPLAGLVRLAKAGRIHKAANSIQYVRKLSDFRAIQVSQLWDDTGTGSFTDDKLYVVQTGTKTIQRCILMTTDPGDLVLDPTCGSGSTAYVAEQWGRRWITVDTSRVALALARARVMGARYAYYLLTDSIEGRRKDAELRNSATVALSTYGDVRQGFVCERVPRITLGSIANNLEIDVFWDEYQTRLEPLRERLNTLLHKKWQEWEIPQEVSDAWSKDAKEAHAAWWNQRTARQRAIDASIAAKAEFENLYDKPYEDKNKVRVAGPFTVESLSPHRVLEMQDNDLRQSALSDYDDPRDVGNFVQVILDTLKASGVQQTDKNARIEFTSLQPWPGLGMICAEGHYTDKDGVGKRAGIMIGPEFGTVARPDLAQAAREAGDAGFDVVIACAFNFDAQSADFTRLGRIPVLKARMNADLHMAEDLKNTGKGNLFIIFGEPEIEILLAPDNEIRVKLNGIDVFNPSTGEVTSSEPDEIACWFVDTDYNEESFFVRHAYFLGANDPYKSLKTTLKAEINQEAWESLHSDTSRPFPKPATGRIAVKVINHLGDEVMKVFTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X525</accession>
    <name>E8X525_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0141</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578545.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0141"/>
    <dbReference type="EnsemblBacteria" id="ADW67217">
        <property type="protein sequence ID" value="ADW67217"/>
        <property type="gene ID" value="AciX9_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0141"/>
    <dbReference type="HOGENOM" id="CLU_2825083_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="6892" checksum="7DE970A1170CC2AB" modified="2011-04-05" version="1">MQGAINIRGGADLPMHLENPVSLGCTTTGEVQPWGARMHAALTVEAGKVNHGDTGFRSSHEVVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X562</accession>
    <name>E8X562_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1264</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579649.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1264"/>
    <dbReference type="EnsemblBacteria" id="ADW68326">
        <property type="protein sequence ID" value="ADW68326"/>
        <property type="gene ID" value="AciX9_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1264"/>
    <dbReference type="HOGENOM" id="CLU_2879570_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="7103" checksum="D420AFD11C73D4D5" modified="2011-04-05" version="1">MTLGSDVYEIIRKIFLVSDELKRLSSEMKDLTSNVKDHDIRLAVIETTLSIAQRSSKLILPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A2</accession>
    <name>E8X5A2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1304</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1304"/>
    <dbReference type="EnsemblBacteria" id="ADW68366">
        <property type="protein sequence ID" value="ADW68366"/>
        <property type="gene ID" value="AciX9_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1304"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_1_1_0"/>
    <dbReference type="OMA" id="IRTQYTI"/>
    <dbReference type="OrthoDB" id="903200at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234396" evidence="2">
        <location>
            <begin position="23"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="141"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="373" mass="39837" checksum="7B1C826F4084D735" modified="2011-04-05" version="1">MQLRSNFAALCVMGLMVGGAMGAEAQTAPAVPAQTPIPAQTPSQVPTTAPLNVDRDPVPSPDPDPAPGVTAAAPTQGPQVEKGQGGRYTLKQDAFEVVLNASVIDGSGQTIQTLQQDAFHVYEDGVPQTINSFKHQDLPVSIGLLIDSSGSMYDKRNAVDKASIDLVKLSNPMDEEFLVDFSTEAFIDTDFTTSVDKLSQGLSYIKSSGGTAAYDALVASADYLTKNAKNTKQVLIIITDGEDNASSATLEQSIRRIQDLDGPVIYCVGLLFGEDTDRRESRHARKVLESLAAETGGQAYFPKSLKEVDGIAAEVAADIRTQYTIAYRSTNPPSKGGYRQVHVEAKSKGFGRLQVRTRNGYYPRTTTGAVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C3</accession>
    <name>E8X5C3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2434</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580786.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2434"/>
    <dbReference type="EnsemblBacteria" id="ADW69470">
        <property type="protein sequence ID" value="ADW69470"/>
        <property type="gene ID" value="AciX9_2434"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2434"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_5_0"/>
    <dbReference type="OMA" id="ICMSIVK"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="266"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="478" mass="52253" checksum="98CAFE0D0A4FE813" modified="2011-04-05" version="1">MHSKLIISVTRWFSAAIGLGGIVFFFHVVLQVNPTTVALTLLLFIHSLASRWGLRYAVVISFAAGACYNYFFLPPVGHFIISDPQNIVALLVFLITSIFASRMSERIREESKEARASKAELEILYRLSRALLQTDEFVQLTKTVPNAVAVATGAQAVLFFLLDGNRIYRFGSDWTPHLSEDALKELSHAPGIISSAGAQEAMIPLRSGVRPRGILIIRGLTLSHQSLDALGGLVSIALDRSNAIDEVSRTEAAKENERLRALMLDSITHELGAPLAFIDRSLDSLLAQGLEPAESRALLGSVQGESNRLSRLVAQAVEMAKFDTQELRMTFVPQSMEEMINDAIQTAEDVLKGHPVQVTLAPRLPSVQADSIWVGRLLTKLLQNAAKYSPDDAPIFITAEQDGRFVTCSIADRGIGIEPIEQSFIFDKFLRSGNREQRSSGTGLGLAICRTIVEAHGGKIEVSSQPGRGSVFSFTLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H9</accession>
    <name>E8X5H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2494"/>
    <dbReference type="EnsemblBacteria" id="ADW69526">
        <property type="protein sequence ID" value="ADW69526"/>
        <property type="gene ID" value="AciX9_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2494"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016846_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="209"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="614" mass="66484" checksum="E360DF457B689ED7" modified="2011-04-05" version="1">MLSKFSVILAKPEPPYLSLLLLLLVLFPLTTTTTNAQSTPIAATSTFNQSGTFAPLPNPAAPATLIVFSDFACPFSARTFFTLQKLSTRYPNSLHILYKQTPLPIHPDAPLAARAALAAARQNRYNAMAELLFANQTHQDLPTFLSFARQLHLDIPRFRRDYDSPAVAAQLATDLEESHAFGVIETPTSFLNGKLLSGLQDEPTLTALIDKASTTPSIAPTLASGNDGTITDPTLLAQILAPTSPTQGPATAPLTIVEFTDFQCPFCRAAVAPMEQLMAARGQEVRWIFRAFPLDFHQFAEQSAEAALAAGEQGKFWPMHDLLFAHQSALTLADLHTYAQQLNLNLPAFDEAMSTHRLAGQVAADRALGLRAGVSGTPTFMVDGHLMVGARSLTELAALADAHRNFAGIQNASARVPTAPAATHQVLGPEPSSGQPDTPITLTWFTDVRSPLAAHQAELLRTLTAHYEGRIRVLFKADPLVTHPDSRLASAALFAALALGGSDKFWPMFDALADRRDLLDRPKLLTIAAAMHLNASAFEKSLDQSENDVTADQQEATRRGISGAPVLFLNTERVDGLQREAFYTAILDRQLKDQLKAQPTTTQATLLTTNPTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K9</accession>
    <name>E8X5K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3633</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581947.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3633"/>
    <dbReference type="EnsemblBacteria" id="ADW70636">
        <property type="protein sequence ID" value="ADW70636"/>
        <property type="gene ID" value="AciX9_3633"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3633"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="OMA" id="MNNNFAF"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="41706" checksum="0580892319836CFA" modified="2011-04-05" version="1">MRRVCITGVGVISSLGNDRAEFWDGLTSGVAAIGPKLGMDMEQFRFKNVAAANGYKPEANFEAKELALLDRFAQFALVAADEAVKQAGVEWTEALREDTAVVTGSCLGGRGAEEVGYWELFHNNKNRVHPLTIPLSMSNAGASHISMKYGTRGAAYTISTACSSSAHAIGQAFWMVRSGAAPMAITGGSEAPLFLGSLKAWEAMRVISKDTCRPFSADRTGLILGEGGAMLVLEPLDDALARGAKPLAEIVGFGMTSDAAHLTNPSGDGATSAMRKAIKDSGLALEQFGYINAHGTATQANDSVESAAIRTVFGKQAVAVSSTKSMHGHTLGAAGALEAVASVMALQCGVLPPTANYTTPDPECELDVIPNEARAVRVEACLSNSFAFGGLNAVLAFKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L8</accession>
    <name>E8X5L8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581956.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3642"/>
    <dbReference type="EnsemblBacteria" id="ADW70645">
        <property type="protein sequence ID" value="ADW70645"/>
        <property type="gene ID" value="AciX9_3642"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3642"/>
    <dbReference type="eggNOG" id="ENOG5030MUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377536_0_0_0"/>
    <dbReference type="OMA" id="GESKECC"/>
    <dbReference type="OrthoDB" id="1968420at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22114" checksum="D2A085B295D87107" modified="2011-04-05" version="1">MLPDPGELAAHYATLNEPDLLDLARTYDSLTEAAQASLRAEFARRGLEPPLIQDELIPTKLVVVERYRDLSEAIVARSYLESAGIQVYLYDENLVRLDWQVSNFIGGIRLKVEASDEAEARELLAQPVPESIEFADGEEFDQPHCPVCSSTDITFQGSSRGPAIAALFIASVPLPPGKKSWICNHCNAHWEDTEDSEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M8</accession>
    <name>E8X5M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581966.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3652"/>
    <dbReference type="EnsemblBacteria" id="ADW70655">
        <property type="protein sequence ID" value="ADW70655"/>
        <property type="gene ID" value="AciX9_3652"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3652"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1658358_0_0_0"/>
    <dbReference type="OMA" id="ANHYVAS"/>
    <dbReference type="OrthoDB" id="2025747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="16860" checksum="26AA6C015EC53233" modified="2011-04-05" version="1">MRRLLKDEVGSELIEFSVSAGVLMMIIFGIMDCSRALYAYHFVAGAARDATRYAAVRGATWSGALCLLSTSFQCAATSSDVTSYVKSITPIGLTTGSLTVLTTWPGTTATGVSCNALGIYNSPGCMVNVKVVYTFSFVLPFLPKNALTLASTSKVMITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C0</accession>
    <name>E8X6C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4227</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71004">
        <property type="protein sequence ID" value="ADW71004"/>
        <property type="gene ID" value="AciX9_4227"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4227"/>
    <dbReference type="HOGENOM" id="CLU_328402_0_0_0"/>
    <dbReference type="OMA" id="CNASISP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="697"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="945" mass="93887" checksum="EB7D5DD84B98A8DE" modified="2011-04-05" version="1">MSKLSLVSSAPSLLPDAVSPGRLVGRLLVAAALCLGSLCPAHAQKATESLVYSFAGTTDSQVPAASLIQAGDGQLYGTTIGNFFTDYGSVYKLGLNGAYTTVYKFGGITDSATPFAPLYQAADGNLYSTTYGNLLFGTDGTVFSITPAGKLTTLYSFTGATDGANPEGGLVQLSDGTFFGATPNAATGYGTLFQIGTAKPLTTLISFNKFNGAGAIAAPVEGTDGNFYGVSGVGGASGFGSIYQLTPSGTLTPIYNFTGLGDGASPFGPLIEGPDGNFYGATGANGTVKGADKNGTIFRITTAGVLTTLHVMNPATDGSSPLALFLGGDGFLYGNTTSGGANSDGTIFRVSLTGTFTKLYDFATGDATAPQMGLVQASDGTFWGSGSSGAANSLGGVFKLTLSPAPPAPVTLTASASTISLGDPVTLTWTVTNAFSNTMRRCNASISPAPASAAGWSGTQPGKFDSTTNLWSGSTTITPAYPGVYTYGLTCGGTESTTATITVGNAAALTITTQSPLSTAYIGVPYAQTIGVSGGVQPYTFAVTVGSLPAGLALNPTTGAITGTPTLTDSSDFTVKVTDSDAAGASSATANLSIAVLQPLKLVTSSLPDGRLGVAYSQQLTASGGTAPYRYTLSPGSALPAGLTLSSGGLISGIPTAAATSNFAVLVSDSGSQSISANLTLTIDPLITTTGKLTLTPAAISVGGTTTASLTITAPAGSPAMTGTVQFTQNGQPIGSPVALTNGTASLTTPAFTTTGTVAVTAFYSGDANFLALGYPSANLTVSVAAQPALVIAPAVATVATGADVSVTATLANFASGAAVTMACSHLPTDVTCSFSNVTTTSATITIHTSTTSAALAPEPRTATSELMLCALPGVILLGLAGRRRRRSLHRLLMLSVVTLIGLSIAGCGSHTTIDHAGTGTSAITVTATAGAQTASAQLSLVVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6H7</accession>
    <name>E8X6H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4293</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71061">
        <property type="protein sequence ID" value="ADW71061"/>
        <property type="gene ID" value="AciX9_4293"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4293"/>
    <dbReference type="HOGENOM" id="CLU_330862_0_0_0"/>
    <dbReference type="OMA" id="GMMEIHG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230282" evidence="1">
        <location>
            <begin position="18"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="817" mass="88252" checksum="D1EAD17C9A4C3DFF" modified="2011-04-05" version="1">MRAFVLMMLALSVGAGAQGLRPVAAFPMREDGLVLRRHVSAGQPFTVAGPEGVIVGEQQGSFEAWVLPVKLLSHFTIEAQVEGYAVPIDLNQAAREIDVRPDRTTITYSHIAVTVRQTMFSADGVGAVVMFAVDSVRPVDLTFRFTGELREMWPKLSSGVPSAEWVERGASGFYVLHSDYPEFAGAVALPGAKSGIMAPFQERPQVHPLEFRLHVDPKADAGKVYPLLMAVGRTKETASTAALEKAMGDVDGRLGAIYSGHAERYKAQAAELTSIRTPDEGLNDDFSWAVTSIGQLRARLGGEMGLVAGYYASGDSARPGFGWFFGRDSLYTLYAVNGYGDFGLARSELEFLMARQRADGKVMHEYSQTAGDLDWKAFPYWYAAADATPLFLTTMLDYVRASGDVAFLAAHKDKVMSAWAFETSHDADHDGIYDNSEGTGWVESWPTSSTHEGMPKQEVYLALMDQQGSAAVGQMARLLKDDTLAQAADARAAKVRAVLEKEYYVSKSGEYGFSQDFGKIDKTSTVFPSVAWWNDGAGYTPGLEHAGVSLRRWASHDFATDWGARDVAESDAMYDPISYHQGSVWPLFTGWAAMAQYRSGHALAGFQSVMANADLTTAQDIGAVTELLSGAFFEPFGRSTSHQLWSSAMVVTPLLRGMFGLEVDGVARTVKVTPRLPADWDSAEVRRLHVGASVVDVLYRREGGFMNVSLSPVSGEAVRLVGPAKVALPAVEVSMGHGLPTPGSRTGQVKVVDETWSGRSLRLEVEGVSGTVGRFTVRQNVSGLKVAVEGGGLDGSALTIPFSGAAGYMSKVVTLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z8</accession>
    <name>E8X6Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582129.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71107">
        <property type="protein sequence ID" value="ADW71107"/>
        <property type="gene ID" value="AciX9_3821"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3821"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="FARISYV"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1135" mass="122018" checksum="00E9CD1B0F462FA2" modified="2011-04-05" version="1">MKPAAFSSRQTSHPSQLSTSLLNSLPQPAKSKGYRLLFALAIIATLFISGRASAQGFGTIVGTITDSTGAVIPNANIKVVNEGTKLTREVKANDQGYYVIPSLDPSVYTVTIEAPGFSSYKQNNVTLLADQSLTISAPLTIGGEAQTVSVESNAVQVNTSTSVLNQVVEQKRIVDLPLNGRNAVSLALLVPGATVGSNSGIDQGITKTFPSAITLSFNGSRSNQSSYNLDGVSNNDTYTNVNMPFPFPDALQEFSVQTANYSTRYGGSAGAVINAITKSGNNGFHGDAFEFVRNAVFNARNYFATTRDQLKRNQFGGTIGGPIMIPHLYDGRDKTFFFFGYQQTEVRNIVNGNQAFVPTAAELNGDFSAYLSATNPANPLGKAYQLVNPITKAPYVNNQIPVASFDKSAVALTKYLPLAGADQSGRVLYGLPSKQSFHEYMGRIDHSIGSKDRISARYYLNKFNNGSFLDQTNYLSEVSPTQSYAHNAIVSDTHIFTPNILNDLRLSYTRVTTNTGPPAGSVNYNDLGVNIYQPAGTKFLGQVTVTGYFGTTGTNLPLKIYRDNYNLADDFTVIHGRHSIVFGVAAVRGTVLLRDAFQAAGNFGFTADSTNNALAGFLLGNVRTFVQAAGETKDNRDHPIAVYAQDDFHATRRLTLNMGLRWEPYLPWVETKGRVEQFRPDNYAAGIRSTVFPNAPAGLIFPGDAGMPYNGVNPSWNVFAPRFGFAYDVFGNGKTAIRGAIGSFHDSQQVGIGNNRFVDVTPFSPTVSLTTPAGPFSNPYLGITNPFPASPVPSANTAFTAPVLVVTYNPANNSKLFVPTTYDFNLTVEQQLKGGFLGRISYVGSLARHVYESVELNPAIYTPGSTLGTDARRGYKGFGSIAEVNDDAVSNYNGVQLSIQRRFEHLTVLANYTFSKSLDDIPYLQSNTNASASNNSALPYGTINRHAFDYGSSDFDRRHIGVLSYVYDLPGASLHNALLKEAIGGWQTTGILRLQSGTPFTVIAGSDRSQTGLNSDRATVVPGVPQYSKTGCTIASACVGYLNQAAFAIPALGSAGNLGKNSLFGPGAINWDVGLLKNIPLGSDRFRLQFHAEFFNVINKTNLNNPVASIATAGFGTVTSSTDPRIGQLALKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A1</accession>
    <name>E8X7A1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4384</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573054.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71335">
        <property type="protein sequence ID" value="ADW71335"/>
        <property type="gene ID" value="AciX9_4384"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4384"/>
    <dbReference type="HOGENOM" id="CLU_053673_0_0_0"/>
    <dbReference type="OMA" id="IYYESKR"/>
    <dbReference type="OrthoDB" id="1022151at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019219">
        <property type="entry name" value="DUF2130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09903">
        <property type="entry name" value="DUF2130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="464" mass="52262" checksum="8826DE243784B6CE" modified="2011-04-05" version="1">MSILSSESALQPTVACPKCGTPVPLTEALAAPLIEATRAEYEAKLRSQNDAVAKQQQELDRKQQATHEVEQQLAKREADIKRRYEEARAEITTQREQLTAEVARQTEAAVTKELAERLIVERKAIAEAEASRAAQRFAGELAERDRDRKEQGEYIERLTAKLMTAQNAEVELRRREREFQDKERELPLRIEQEVSGRLDQVRAAAANEASERLTLQLSEKERQIKDLATKLEEASRKAQQGSQQSQGETLELLLEDQLRRQFPFDELQPVPKGEFGGDTLHVVRDSSGRECGRILWEFKRTKIWQAAWLAKLKGDQRSARADIAVIVSQAMPPDVTHFNEVDGVWVSSLGCTLPVATALRASLLQLAGQKRSAEGQQTKSELVYAYLTGPQFRGRIEAIAERWSEMQKDLADEKKATMKRWSKREAQLHTLLDSTAGIYGDLQGIVGRDLAEIEALGETLLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B3</accession>
    <name>E8X7B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4396</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573066.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71347">
        <property type="protein sequence ID" value="ADW71347"/>
        <property type="gene ID" value="AciX9_4396"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4396"/>
    <dbReference type="HOGENOM" id="CLU_124534_0_0_0"/>
    <dbReference type="OMA" id="WFVFPQI"/>
    <dbReference type="OrthoDB" id="1625285at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014937">
        <property type="entry name" value="DUF1810"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036287">
        <property type="entry name" value="Rv1873-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08837">
        <property type="entry name" value="DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008546">
        <property type="entry name" value="UCP008546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140736">
        <property type="entry name" value="SSF140736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16896" checksum="B460E38A84EC47E3" modified="2011-04-05" version="1">METQSDPYNLQRFINAQESTFDAARAELEAGQKRSHWMWFIFPQIKGLGSSPTAQRFAISSLEEGAAYLEHRVLGRRLEVCTALVNRVRGKSVDDIFGYPDNLKFHSSMTLFAEVADKFGFEATVFREALAIHFAGQRDTATMKQLDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E2</accession>
    <name>E8X7E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4428</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71376">
        <property type="protein sequence ID" value="ADW71376"/>
        <property type="gene ID" value="AciX9_4428"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4428"/>
    <dbReference type="HOGENOM" id="CLU_001265_62_1_0"/>
    <dbReference type="OMA" id="FATISYM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="44255" checksum="CBE270CF8711FACB" modified="2011-04-05" version="1">MKPIYVLTWLLCAIFYFYQYAVRSAPGVMQSELTVAWGGNHIGGIISAYYVAYALMALVAGQLLDRYGAHRTIPYGIALVAVGCIIFAQGSEPAGAIGFVLQAIGAIFAFIGSSYVAARYLPARMLAIFVGFTQCLGMAGAAFGSKPVHMAIDPLGGFHMQWQRVWLIFAGLGFVLALATWLIMPREQGDSPEHHAPLSTQALLAPFKIVFGNPQSWLAGIIGGLLFVPTTIGALVWATSFLHNGEHMSMSSAASDASMVPIGWVIGCPLLGYISDKLGRRKPVLIGGGLLILASGLAAIYVPVGTLPRYSVALVMGIASGAAMIPFSMIKEANPAGVKGTAAGVMNFLVFLTTGLISPFISRLMLPSQDQPLSLEGFQHAFVPLVVGVVVAIILSFVIRETGLAQTKKILLAVPAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R6</accession>
    <name>E8X7R6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4569</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71500">
        <property type="protein sequence ID" value="ADW71500"/>
        <property type="gene ID" value="AciX9_4569"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4569"/>
    <dbReference type="eggNOG" id="ENOG502ZX5P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608528_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="17225" checksum="54FFD7E5A817A154" modified="2011-04-05" version="1">MQTNQIVALIDQEIAHLQQARALLTGSDEREETGKQRGRPKGSLNKPTKVSGGVVPPTGKRSISEEGRARIAAAQKLRWAASKKSTKPVKAAKKANKAGVTKVASPLLKKTAKASKKTSRAKIVKAKPAVAKKTSFKPGTSKNVSSANAAASLAGGETQSTTENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V9</accession>
    <name>E8X7V9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4613</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573262.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71543">
        <property type="protein sequence ID" value="ADW71543"/>
        <property type="gene ID" value="AciX9_4613"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4613"/>
    <dbReference type="HOGENOM" id="CLU_1523078_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="18777" checksum="4212D42AF8F98E9B" modified="2011-04-05" version="1">MLGESRKEAIGRLVRENQGRLQRSDFLDGLSLAVGSAIRPSQLLSLKATDNVRTALSTGYAAAVNGQPDTGHGFFSRDESLSALGIPLLLSRSLPEENAFLWVKQSAWCGAVAITTGKVLGACEGIRAFDGDAVSLLSEDHTQGIIFDRHDDFVQNFEASVWGSRWLAAASSLGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI2</accession>
    <name>E8WVI2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1370</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579752.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1370"/>
    <dbReference type="EnsemblBacteria" id="ADW68430">
        <property type="protein sequence ID" value="ADW68430"/>
        <property type="gene ID" value="AciX9_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1370"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_1_0_0"/>
    <dbReference type="OMA" id="KLMITHH"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233903" description="DUF305 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="62"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25280" checksum="781CB5EC1D927AAD" modified="2011-04-05" version="1">MPHLHPHKSLSQALVLALTTAAFTLAQAQSAPPIIQPGAPGTPSKTLPANTTGTLPQRSQADIDFMQGMIMHHGQAIQMTALIQSHTENKEVRSIGQRISLSQTDELKFMRRWLETRNEPISMSMPGMPDMDMIGKPMPAMPGMLTPPQMEALRNAQGPQFDHLFLTGMMQHHNGALVMVKDLFNQPGAGQDADLFDFATDVDNTQRAEIRIMQQILDQIRSDKHKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI6</accession>
    <name>E8WVI6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1375</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579756.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1375"/>
    <dbReference type="EnsemblBacteria" id="ADW68434">
        <property type="protein sequence ID" value="ADW68434"/>
        <property type="gene ID" value="AciX9_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1375"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_0"/>
    <dbReference type="OMA" id="MGMTASF"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="136"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="476" mass="54104" checksum="1DF13DBEA8757148" modified="2011-04-05" version="1">MSSEYRDFLELSYSELEDLNLAAKEQRRNRVDPAKIQEERLAYLRDERRIKAVMVVFSDLEGRLHMLDYDKKFLVNSYDNLTFDGSSIRGFTAQRESDLRLAIDWAAFYWTPADVFGAGKVLVFGEVIDKNGEHYAGDLRGVLKNYAKEQFDKNGYHLNAANEIEGFLFEGIDAERSFHELGSFEYVNKGGYYHSLPGDPLREFIDTTAEVQRAMGFENEKDHPEVAPSQFEINYTYGDVVMAADQIQLYKLICRQVATQMGMTASFLPKPVTGVNGSGMHTNVSITKDKTNLMWDPNGEEKTSKFGWEFVDRILTVGSDLCVVLNASVNAYRRLDPHFEAPNQIKASATDRGSMVRIPIGNAKSARVEVRSVGPDANPYMVLYTIFKTGLDGEIAKIENLRQAERYLPDNIYTALEDFNKSEWVTTILGGDVKQRYSDLKQASADRCPRLLGTIVKPCEIQFHHDVYNQLLWGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK5</accession>
    <name>E8WVK5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2502</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580850.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2502"/>
    <dbReference type="EnsemblBacteria" id="ADW69534">
        <property type="protein sequence ID" value="ADW69534"/>
        <property type="gene ID" value="AciX9_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2502"/>
    <dbReference type="eggNOG" id="ENOG502Z7KX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087250_0_0_0"/>
    <dbReference type="OMA" id="ACVQVFA"/>
    <dbReference type="OrthoDB" id="1769199at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41260">
        <property type="entry name" value="PTHR41260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="264" mass="27894" checksum="FD070068394DE7B0" modified="2011-04-05" version="1">MTPQDTALLATAKQNLEAESFAMKVAAKVGVPFETLMRMLPAGAQASIGEAVNRALEQCLQVALLDTRTTIAPRSKRLHTAATAVTGAIGGFFGLPGLAIELPVTTTVMLHSIAEIARSHGEDLTQPEPALACLQVFALGPNHTRLNSGAEASESAYYATRAALTQVTREAASYVAEKGLAKEGAPALVSFIARVAARFGLEVSEKAAAQLIPVAGAAGGLALNIMFTNHFQRLAEGHFAIRHLERKYGQPEVHQLYESLPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP3</accession>
    <name>E8WVP3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bridging integrator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2542</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2542"/>
    <dbReference type="EnsemblBacteria" id="ADW69572">
        <property type="protein sequence ID" value="ADW69572"/>
        <property type="gene ID" value="AciX9_2542"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2542"/>
    <dbReference type="HOGENOM" id="CLU_2601151_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8622" checksum="901AB661E8CDA665" modified="2011-04-05" version="1">MMKSQIYPLVNRLSVPAPVAEMSAVHGVLESDEVKQIDLATDHEIQLDASLNESAAMEEEDDELEEQDRVEAAAAANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP6</accession>
    <name>E8WVP6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580890.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2545"/>
    <dbReference type="EnsemblBacteria" id="ADW69575">
        <property type="protein sequence ID" value="ADW69575"/>
        <property type="gene ID" value="AciX9_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2545"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_0"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16072" checksum="0B79184BD5822251" modified="2011-04-05" version="1">MAYKTINGITSSIIPFYLQDGTLFVLLGQRGPKSKAFANSWALVGGFLDPGSESLEQCAARELKEETGIEVSPKSMKLVTVQSDPKRDPRGQIIDTVWSTLLQSELPSAAADDLQAVAWLPLSEALNMELAFDHQDSLRRFAAIEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ8</accession>
    <name>E8WVQ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2560</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580902.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2560"/>
    <dbReference type="EnsemblBacteria" id="ADW69587">
        <property type="protein sequence ID" value="ADW69587"/>
        <property type="gene ID" value="AciX9_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2560"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="217" mass="23908" checksum="AB11E3162807C0B8" modified="2011-04-05" version="1">MADSLETFDVQQFLSKAGVGKTIASFSKGSPIYAQGDTCDAVYYVQDGTIKLTVVSESGKQATIALLNPGDFAGEECMSTLQPFRSASATALTDCVLLRLTKIEMKRVVDAEVAMSGLFIAHLLARTNRIQADLIDQLFNSSEKRLARTLLLLANFGKEGVTETLVPDISQETLAAMIGCTRSRVNFFLNRFRKLGFIDYDERIRVNKSLLQVILHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR7</accession>
    <name>E8WVR7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2569</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2569"/>
    <dbReference type="EnsemblBacteria" id="ADW69596">
        <property type="protein sequence ID" value="ADW69596"/>
        <property type="gene ID" value="AciX9_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2569"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1353044_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="61"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="22711" checksum="E07CD1FF66E749A4" modified="2011-04-05" version="1">MTEPSKMSHRYYFRIVRGTYPPLMTTSVSNRRSFFLSAASLAGAAAVSSTLIAQPTPTNLTAFLQTYDEAWASHNPQAIAMLHAEDVLVVNRFGSMLEGRAELEKAMQFLHGPGGPFHSITFPRQKLLVSRMLNTDMATLHARWKNPTMGPGDQLAHGSQTPWVDLLSTYLLMRRGKTWQIVQHDLHSVDPIKFPFKTKWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU7</accession>
    <name>E8WVU7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ordered locus">AciX9_3705</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582015.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3705"/>
    <dbReference type="EnsemblBacteria" id="ADW70706">
        <property type="protein sequence ID" value="ADW70706"/>
        <property type="gene ID" value="AciX9_3705"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3705"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_0_0"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="11688" checksum="C4349FDDC0B466BF" modified="2011-04-05" version="1">MYAVIRTGGKQYRVAPGDVLKIEKVAHENGAVEFGEVLAVSGDAGSFEQSLEGAKVTGTVVGEGRGEKILVFKFKRKKQYKRMQGHRQSFTEVKINEVLVGGKSFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW40</accession>
    <name>E8WW40_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0274</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578674.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0274"/>
    <dbReference type="EnsemblBacteria" id="ADW67346">
        <property type="protein sequence ID" value="ADW67346"/>
        <property type="gene ID" value="AciX9_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0274"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_0_1_0"/>
    <dbReference type="OMA" id="QLHIFAA"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="26053" checksum="4090326012A5E7AC" modified="2011-04-05" version="1">MANGKFISYLRVSTARQGASGLGLEAQREAVSRYLNGGRWTLVQEVMEVESGKRNDRPAIAEALRLCRLHKATLVIAKLDRLARNVHFISSLMKTGVDFIACDFPEANRLTVHILAAVAEHEATMISARTKAALEVAKERGVTLGGMRGNLGRMASMASHGTQRSAIVRADRASKRSADLLPVINELQRGGLRTLREIAEGLNSAGISTARGGKWSATQVMRELRSEANWQDHSRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW50</accession>
    <name>E8WW50_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0284</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0284"/>
    <dbReference type="EnsemblBacteria" id="ADW67356">
        <property type="protein sequence ID" value="ADW67356"/>
        <property type="gene ID" value="AciX9_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0284"/>
    <dbReference type="HOGENOM" id="CLU_3007916_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="56" mass="6295" checksum="0B25F7BF25809FA0" modified="2011-04-05" version="1">MVTDLMGQTLRYTGNRTNVTRRQTQPYSIGTSVAFFYLVAPMWLSRSGQDGATYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW78</accession>
    <name>E8WW78_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1402</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579783.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1402"/>
    <dbReference type="EnsemblBacteria" id="ADW68461">
        <property type="protein sequence ID" value="ADW68461"/>
        <property type="gene ID" value="AciX9_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1402"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_0"/>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="OrthoDB" id="1012819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="530" mass="58591" checksum="203DB510B34A969A" modified="2011-04-05" version="1">MAYKDLREWIARLDKADELVVIKEPVSPYLEMAEIADRAAKMPATATKGPGGPALLFENVTGHPGARVLMNQFGSERRMQLALEVPSLDDIAGRIRTLLHPPTPTGFMDKLKLLPMLAEVGSFFPKVIDKADAACKQVIHKGADVDLSKLPILTTWPQDGGPFITLPCVITRDSKSGKRNVGMYRMQVYDKQTTGMHWQRQKNAAEQLRDRLRASSEDATAAVDLMALTAGGTVAAPDLSSLNQQTITKIRGDRMEVAVAIGTDPATTFSAIVPAPPEIEEYLISGFLRQKPLELVKAETVDLEVPAHAEYILEGFVNLGELRTEGPFGDHTGFYTMQDEYPVFHLTAITHRKNPVYAATVVGKPPMEDAWMGKAVERIFLPLMQLTMPEIVDVNLPAAGVFHNLMIVSIRKSYAGHARKVMNGVWAMGQAMFTKCIIVVDEDCDVQDLNEVTLRTANNIDPERDIQFTLGPVDSLDHASRLPNFGSKMGIDATRKWAAEGFTRQWPPMLAMPKEVKAKVDALWPKLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW96</accession>
    <name>E8WW96_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1421</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579801.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1421"/>
    <dbReference type="EnsemblBacteria" id="ADW68479">
        <property type="protein sequence ID" value="ADW68479"/>
        <property type="gene ID" value="AciX9_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1421"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052486_2_0_0"/>
    <dbReference type="OMA" id="MGLGWHP"/>
    <dbReference type="OrthoDB" id="710313at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="44852" checksum="4FB3EC5AE0D7786F" modified="2011-04-05" version="1">MYLNIIKKRLEDVWHGVFGREGRRSAAFPLLVILVVLAGTGAIYLAHRHAKFHELETKIQGDTNPAGGGEERPGGRDPIVLTRAQTLGGYVPEFHSATLLPGLGLGVLQITAFLPNKGEQPLLVAPTVPQMTDGSWPVRTGSNDVHGALEAPWSGLFAGVTSPTGLTLSSQWNDKMLTIPVQPQQAASLAEGGLLQGQDTDTAEVTKTDKGAVLSGTFRARDFDGHWPSSSDVSVRADLQATTLELTVDAKNAGDQPEPMGLGWHPRFLIQSGDRSKVELKLPNGEKLLIASSTPAIPTGKTGALGAALQGFAGRGGALGDDSVDEAMVHLKPSASEQGPTAEMRDPAAGYGLRITAVSATIREMRVYAPARGNFVSVGTQTNYDDPFGHEWNADDSPIATLLPGQTIEWKVRLELFPIPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC6</accession>
    <name>E8WWC6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0103</name>
        <name evidence="8" type="ordered locus">AciX9_0709</name>
        <name evidence="9" type="ordered locus">AciX9_0791</name>
        <name evidence="10" type="ordered locus">AciX9_1456</name>
        <name evidence="11" type="ordered locus">AciX9_1507</name>
        <name evidence="12" type="ordered locus">AciX9_2000</name>
        <name evidence="13" type="ordered locus">AciX9_2024</name>
        <name evidence="14" type="ordered locus">AciX9_2086</name>
        <name evidence="15" type="ordered locus">AciX9_3135</name>
        <name evidence="16" type="ordered locus">AciX9_3438</name>
        <name evidence="17" type="ordered locus">AciX9_3658</name>
        <name evidence="18" type="ordered locus">AciX9_4522</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="18 19">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
            <plasmid evidence="19">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
            <plasmid evidence="18">pACIX904</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67188">
        <property type="protein sequence ID" value="ADW67188"/>
        <property type="gene ID" value="AciX9_0103"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67779">
        <property type="protein sequence ID" value="ADW67779"/>
        <property type="gene ID" value="AciX9_0709"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67860">
        <property type="protein sequence ID" value="ADW67860"/>
        <property type="gene ID" value="AciX9_0791"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68509">
        <property type="protein sequence ID" value="ADW68509"/>
        <property type="gene ID" value="AciX9_1456"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68560">
        <property type="protein sequence ID" value="ADW68560"/>
        <property type="gene ID" value="AciX9_1507"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69045">
        <property type="protein sequence ID" value="ADW69045"/>
        <property type="gene ID" value="AciX9_2000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69069">
        <property type="protein sequence ID" value="ADW69069"/>
        <property type="gene ID" value="AciX9_2024"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69130">
        <property type="protein sequence ID" value="ADW69130"/>
        <property type="gene ID" value="AciX9_2086"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70147">
        <property type="protein sequence ID" value="ADW70147"/>
        <property type="gene ID" value="AciX9_3135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70443">
        <property type="protein sequence ID" value="ADW70443"/>
        <property type="gene ID" value="AciX9_3438"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70661">
        <property type="protein sequence ID" value="ADW70661"/>
        <property type="gene ID" value="AciX9_3658"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71463">
        <property type="protein sequence ID" value="ADW71463"/>
        <property type="gene ID" value="AciX9_4522"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0103"/>
    <dbReference type="KEGG" id="acm:AciX9_0709"/>
    <dbReference type="KEGG" id="acm:AciX9_0791"/>
    <dbReference type="KEGG" id="acm:AciX9_1456"/>
    <dbReference type="KEGG" id="acm:AciX9_1507"/>
    <dbReference type="KEGG" id="acm:AciX9_2000"/>
    <dbReference type="KEGG" id="acm:AciX9_2024"/>
    <dbReference type="KEGG" id="acm:AciX9_2086"/>
    <dbReference type="KEGG" id="acm:AciX9_3135"/>
    <dbReference type="KEGG" id="acm:AciX9_3438"/>
    <dbReference type="KEGG" id="acm:AciX9_3658"/>
    <dbReference type="KEGG" id="acm:AciX9_4522"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_0"/>
    <dbReference type="OMA" id="VEHIFGF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0614">Plasmid</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW69130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW70443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW70661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADW71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="36414" checksum="F7BF95E57E2B0B5F" modified="2011-04-05" version="1">MAMKQQTFASQSIFEKYGRKSRRELFLDEMEVVVPWPELQALVEPHYPKAGNGRRPVGLAIMLRTYFMQQWFNLSDPGVEEAFYESFTLRRFAGVDLGVAPAPDETTVLRFRHLLEKHDLGGAMLDAVNLHLAARGIRIETGTIVDATIIHAPSSTKNEKKERDPAMRQTRKGKQWYFGLKAHIGVDAKEGHVHSVATSAANVSDVHMLPDLLHGEERKVWGDGGYQGQTKAIRQAAPKAQDMTCKRTRFKNYVDEAAKKKNTTKSKVRAKVEHVFRILKRVFGFDKVRYRGIAKNHHRLCANFALINLYLHRKHLAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI5</accession>
    <name>E8WWI5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2624</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2624"/>
    <dbReference type="EnsemblBacteria" id="ADW69649">
        <property type="protein sequence ID" value="ADW69649"/>
        <property type="gene ID" value="AciX9_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2624"/>
    <dbReference type="eggNOG" id="ENOG5033U05">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650410_0_0_0"/>
    <dbReference type="OMA" id="KLPRINQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="395" mass="42956" checksum="082BD783F58B82E6" modified="2011-04-05" version="1">MRVFWAGSVGMFLLTWLRGWLEARAGVPRNGWDPLDEPLFGDLLEYVPTLKLVHTSAFWGNPVTSPVAYPPFGAVLFRGLYLGGHPVAVYVVIAALAAGVVVWGVVRALRAEGIGWATAILFPVTVGLVSFPIRGLVERGNVELLLWIFAATGSWLYVRGRNDGAAVLWGLAAGVKLYPVIFLALLLPRRAWRAFGVGVGTFVGATVASMIYLGPTVGEAWRGSLKNVFGYQGIRVAEWSLHELVANHSFFGLVKFVATLMGVAPGRLTGPYYLCGAVLFAVVFFGRVWRLPVANQLLMVSLFMVMLPPISYFYTLVHLYAPFVVLMLVAVRAERLGVKVPGLGGALVLFVPVFGSAALMTARTVYVFGGLVQAVVLAVLFWCSVRYRFEVVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS5</accession>
    <name>E8WWS5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0331"/>
    <dbReference type="EnsemblBacteria" id="ADW67403">
        <property type="protein sequence ID" value="ADW67403"/>
        <property type="gene ID" value="AciX9_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0331"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_7_2_0"/>
    <dbReference type="OMA" id="FAARHHF"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="32839" checksum="0E5CABE74567FDE5" modified="2011-04-05" version="1">MGQMILGSSTHVFLPQRLHPGLLDALANGGAKTIEVFAARYHFDYADRAQVKEIAGWFRSNPVTASLHQPLTTETTFSRHAAMSLDLIDREKMHRIEAMDEVKRALEAAEQIPFESCVLHLGMKGDKWSEATLEFALTAVDHVKAFASPLGVKLLLENLQNEVATPEHLVDILRIGHFDSVGVCLDTGHAHLSEGGIAGAFEVLKGRVVEVHLHDNNGMRDEHLWPASGSERSVAAAKGSIDWAETYRLLDTLPAATRGVLEIGYEGFETAEAVSRMTGEVLSHRTRLLEEAAAFDEGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX22</accession>
    <name>E8WX22_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1530</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579902.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1530"/>
    <dbReference type="EnsemblBacteria" id="ADW68583">
        <property type="protein sequence ID" value="ADW68583"/>
        <property type="gene ID" value="AciX9_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1530"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_15_2_0"/>
    <dbReference type="OMA" id="VQITPQI"/>
    <dbReference type="OrthoDB" id="757027at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="195"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="44705" checksum="50837D24264BCED0" modified="2011-04-05" version="1">MPQTDQTGTLPPATPPVPAERPHALAGRILGIGMAVAALVTLGLVVAQTDLHPRTDDASVRANYIEIAPEVSGRLVDLPIRDNEYIKQGDPLFLIDPRPYEYALKQALSDQDDLEQQIIDARRHIAAQASAAQAARATLVSSQTGIQTAGSTVDVASATVSRAKASVEAADAQLKLATNNLHRIEPLLKKQYVTVEQIDQANTTVRVAQGSYDEAVAALNVAQAQQQQASHRKVEASAQANESEARLGQAIHAIDTVDTLVSQRPSKAAKVDSARLDLERTKVVAPFNAYVTNMNISQGAYARPGQAMFTLIDTRTWYVIANYRESKLKNIHLNDHVDVFVMGHPDRRFNGIVESIGYGVFPEDGAVAGGLPNIDRTLNWVHLSSRFPVRIRVNDPDPELFRIGATAVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX68</accession>
    <name>E8WX68_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2686</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581025.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2686"/>
    <dbReference type="EnsemblBacteria" id="ADW69710">
        <property type="protein sequence ID" value="ADW69710"/>
        <property type="gene ID" value="AciX9_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2686"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_29_4_0"/>
    <dbReference type="OMA" id="DMAVYLD"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7845" checksum="7C37CF40DEE87B4C" modified="2011-04-05" version="1">MGDVLIPLGQRIRDLRIARGWRQIDLAEHSGVHEVHLSLLERGKHEVGVQRLKDIVTALDSSLSEILKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX85</accession>
    <name>E8WX85_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsQ</name>
        <name evidence="11" type="ordered locus">AciX9_2703</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2703"/>
    <dbReference type="EnsemblBacteria" id="ADW69727">
        <property type="protein sequence ID" value="ADW69727"/>
        <property type="gene ID" value="AciX9_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2703"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045540_0_0_0"/>
    <dbReference type="OrthoDB" id="1270665at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045335">
        <property type="entry name" value="FtsQ_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35851">
        <property type="entry name" value="PTHR35851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="10">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="47041" checksum="182028DE6A6A961E" modified="2011-04-05" version="1">MLEVPEKTYASKSAGQTVTPRRVSKPPAAGRDTSDDFARPASKQTRRSAAAGDDDGYTRAHGQRFTGLRFRLKGGVPSSVAGRIAAGVVVLTGLVGFTAVLWAARSSLLHDPRLTIASSASIQIVGNRRLTRPQLLSVFGEDVDRNILTVDLADRKAELEQLPWVEHATVMRLLPNHVRVAIIERVPVAFVRQGGHIGLVDKTGVLLDLSPEAASDNHYSFPVVTGVTADMPISTRAARMKLYQGFLDALDAGKDKISDKLSEVDLSSPEDIKALIPSGTGPDTRDILVHFGDDDFLARYQRFEQRLPEWKQQYPKLASADMRYEREVVLEMAPGNAVPVSEEEKKRVAGAQAVAERGILGGKNKNLPKPTALKPTVKPATKAPTPAAHKPWVKPTVAKPAVAHKPAATKPAATPAPKPYVSPMHIHNPMAVEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA5</accession>
    <name>E8WXA5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2723"/>
    <dbReference type="EnsemblBacteria" id="ADW69747">
        <property type="protein sequence ID" value="ADW69747"/>
        <property type="gene ID" value="AciX9_2723"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2723"/>
    <dbReference type="eggNOG" id="COG3305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113251_0_0_0"/>
    <dbReference type="OMA" id="RRIEFFT"/>
    <dbReference type="OrthoDB" id="1920116at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021125">
        <property type="entry name" value="DUF2127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09900">
        <property type="entry name" value="DUF2127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="20960" checksum="7C573D37EA1AA90B" modified="2011-04-05" version="1">MSNRMSEEVLQNERETEAAATEDRPSLHDNGLLLIGLFKLSKALFFFCAGLGVIHFMNKNLSDEVIRLAMALKRDPEGRIVQLLLEKVDLVDAHTMRRIEFFTFGYSGLALTEGIGLLLKKVWAEYLTLLLTISFLPWELFELVRRASLFRFGLLATNLAVLGYLIWLLQRKKQSRVEAADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC7</accession>
    <name>E8WXC7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578788.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0388"/>
    <dbReference type="EnsemblBacteria" id="ADW67460">
        <property type="protein sequence ID" value="ADW67460"/>
        <property type="gene ID" value="AciX9_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0388"/>
    <dbReference type="eggNOG" id="ENOG5033HJW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134923_0_0_0"/>
    <dbReference type="OrthoDB" id="1612632at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="18105" checksum="42896DA2A69A6320" modified="2011-04-05" version="1">MTAEEAFLGKARGSKILLDTNLLLLLLIGSFDRSLITRFKRTSQFTPSDFDALVELLSASRQLVTTPHLLTEVSSLANALPSYLKLEWHQHLAEQTSRFFEVFIASETLMKQPAFLALGLADSAVFAAAAESLVLTEDYRLAGSLRASGMTAMSFSDLRAFVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL4</accession>
    <name>E8WXL4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1577</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1577"/>
    <dbReference type="EnsemblBacteria" id="ADW68630">
        <property type="protein sequence ID" value="ADW68630"/>
        <property type="gene ID" value="AciX9_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1577"/>
    <dbReference type="HOGENOM" id="CLU_2806441_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7606" checksum="1B8C4D4CEDC696AE" modified="2011-04-05" version="1">MVRTAPQMTTRTPYRHHKVTTNLEAVITENNDFQGDSNVCTLYQSEQFRVVMIVGCLKAPQEFSSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ0</accession>
    <name>E8WXQ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1613</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68666">
        <property type="protein sequence ID" value="ADW68666"/>
        <property type="gene ID" value="AciX9_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1613"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388796_0_0_0"/>
    <dbReference type="OMA" id="SHNNRIR"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="363"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="3">
        <location>
            <begin position="455"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="531"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="781" mass="79156" checksum="0F90AD4C1C2C5764" modified="2011-04-05" version="1">MALVVLLLPSQAQTTQATTVPILLPSGLVYDAQGNLYLAETAAHLILRVSPSGALTIVAGTGTQGYAGDGTLPTQALLDSPTALAITPTGDLYLADTHNHAIRRIDAATQIITTVAGTGTPGRSPDGTLATKAQLDTPTAIALDSSQNLYIADTRNHIIRRVDATTHLITTLAGTGTQGFSGDAGPALAAQIDTPTGLALDASNNLYLADTHNHRIRRIDAVTHIITTIAGNGTPAFTSDNIAATSATLYLPRGITLDPSGNLLIADSANHRIRRIDAVTGLITTLAGDGTQTYAGDSTPATTASLDTPRAIALSPATLPTLTDTANQRIRQIDTAAVIHTIAGLGLTQSSTLLLTAPSTMAYGTGSVLATLAASPATGPITFFETSGSLPQTLSTVPLSANSATMSTAAFNTGTHHIDATYSGDTTHAAAQSTTLALTIAPAQLIATPIPINLLYGQPIPTLTGTYTGVLPQDANKVTITYSTQATPISNPSAYPITATLTGSGAGNYTLATAPAAVTITKAPATLTLTSPTATSFAIHAATTTTGTPTGTVSLLDGQTPIATATLTPTGDATLTPSLTAGGHTLTATYPGNPDFLPATSTPTVITIAPTAVADFTLAATGQTTLTVPSGTAAAFSFATTPVNGTLSSPIQLSASGLPTGATASFNPAYLPPGGSINAFILTIQTPKLAHLTPLFPPRTVVLLAIAMPLLLLRRRRIHTLIPAILATLLLATTTACGDRTNLSAATSVPTRTYTITVTGTATAVTGATLQHTATVTLNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU1</accession>
    <name>E8WXU1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">AciX9_2762</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581101.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2762"/>
    <dbReference type="EnsemblBacteria" id="ADW69786">
        <property type="protein sequence ID" value="ADW69786"/>
        <property type="gene ID" value="AciX9_2762"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2762"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_0"/>
    <dbReference type="OMA" id="PFGRYVM"/>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW69786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="564" mass="59493" checksum="A7789A198993ED59" modified="2011-04-05" version="1">MSNDHNPKKYSIPLTEGPSRAAARSYLRGVGFSKEDLHKPIIGVANTWTEIGPCNFHLRDVAAAVKQGIRDAGGTPMEFNTVTISDGITMGTEGMKASLISREVIADSIELVARGNLFDGIVCIAGCDKNMPGTIMALARLDIPGIMLYGGSIAPGRLAQPDGTHKDITILNVFEAIGSHAAGRITDDQLEAVEAAACPGPGACGGQFTANTMAMAGEFLGISPFNLTGVPAMSLEKAEASRAAGRMIMDLCRNDIRPSHILTRNSLENAIAAVCASGGSTNAVLHLIAIAREMNIPLDMADFDRISEQTPFICDLSPGGKYVAKDYQDAGGSRVLAARLKQRGQLHDIPTVSGKTIFEEAALAIETPGQPVIREWSDPLKQTGGLVIMKGNLSPEGSVIKVAGHERIHHTGTARVFDSEDLCFAAVQAGQINPGDVCVIRYEGPKGGPGMREMLAVTAAIKGIPELSETVALITDGRFSGATRGLMCGHVAPEAFLGGPIAAVHEGDTITFDIPNRQLTLNVSEEEIATRLAKWKAPQPRYKRGVFAKYAASVSSASEGAITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ7</accession>
    <name>E8WXZ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0464</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578864.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0464"/>
    <dbReference type="EnsemblBacteria" id="ADW67536">
        <property type="protein sequence ID" value="ADW67536"/>
        <property type="gene ID" value="AciX9_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0464"/>
    <dbReference type="eggNOG" id="COG4964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017952_2_0_0"/>
    <dbReference type="OMA" id="TELMIMV"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230443" evidence="3">
        <location>
            <begin position="33"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="T2SS-T3SS_pil_N" evidence="4">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="484" mass="51802" checksum="FF21EC0B89822D01" modified="2011-04-05" version="1">MNVKKRIPLTSFVPALLLLAGTLPFNPCSAFAQSVQAPGDSPTAHEARKRMDMHDMGGDETLHLLVGHSMVLHSTSNIKRIFVGNPTVLQSYTGGPSEIVLTAKATGVSSLVVWDTQGQSCLYTIAADMDPETLQRSMHDAYPKSQIDVGGHEGRIFLSGTVPTQEASDNAFKLASSYSKDVVNSIRVVTIHGKQVQLKLRIVEVDRTKMEQFGINLFRPTASNAVGGLTTGQFPSLATYATGTPATATAPAVPATINVNNPLNFFIYSFSHEIGATIQDLEQKQILQVLAEPTLTAMSGQSAKFLSGGEFPFPVVQGGGSAAGVAITISFRPYGVKVDFTPTVNEDGSIHLKVAPEVSTLDFSNAVTISGFTIPALSTRRAETEVEILNGQTFALTGLLDHRTTESLSQIPGISRLPILGKLFATTKSYTHSVIELVVLVTANVVDPLTQPTDTTQPDMAVPNLDKSVFDNDLSKEQKLPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY53</accession>
    <name>E8WY53_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1628</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579999.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1628"/>
    <dbReference type="EnsemblBacteria" id="ADW68680">
        <property type="protein sequence ID" value="ADW68680"/>
        <property type="gene ID" value="AciX9_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1628"/>
    <dbReference type="HOGENOM" id="CLU_1624803_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="17048" checksum="FA2BD65990BCFD0E" modified="2011-04-05" version="1">MEQKTAAGKRKAVAGRVTGEDGQAALELALVLPMLLLLVTGMCTYGLSLRSYMVLTDATNEAARQLAVSRGQTVDPCWTAAYSIINAAPSLNTNYMTLTISLNGNTYTGPNCSSASTYSGAAGNLTINTPAVVTLNYSLCSFAMFGRPTTACTLTATTTELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY82</accession>
    <name>E8WY82_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1659</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580028.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1659"/>
    <dbReference type="EnsemblBacteria" id="ADW68709">
        <property type="protein sequence ID" value="ADW68709"/>
        <property type="gene ID" value="AciX9_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1659"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_0"/>
    <dbReference type="OMA" id="RRMDTGQ"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="494" mass="52111" checksum="E1C6BF592E4CC737" modified="2011-04-05" version="1">MSALLEKTVLMDTAVWDGKMLSGGWITGSGGLAEVTDKATGEVLAKVGVASAEDVHRACDAAAAAAAGWAATPAEKRAAIVKRAGQLLAEHTDEAVYWLVRESGSTKFKAGFEVQLTVAHFENSAAYGRKPTRTIVSEDEHMISYYDRVPLGVVGVIGPFNFPLILGLRSVSAALATGNTVVLKPSLNTAVSGGILIARLFEEAGLPEGVLYVLPGEGPAGSVLTENDHVKMVAFTGSTSVGKKIGAAAGAALKRVSLELGGKNPFIVLADADLELAARAGAFGTFLHQGQICMTIGLHLVHESLVDRYAERVAELGRELKVGDPWKEQVALGPLINEKQAANVERIVKETVAAGAELIEGGTRDGLYFRPTVLKYVPKDSAAFKEEIFGPVATIVSYKSEDEALAIANGTGYGLSSAVFGELDHARAVGARIDAGMVHVNDQTVMEDARAPFGGTHQSGNPTRIGGESDLEEYTTFRWTTETRKPQPYALPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD3</accession>
    <name>E8WYD3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDP-N-acetylmuramate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2816</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2816"/>
    <dbReference type="EnsemblBacteria" id="ADW69839">
        <property type="protein sequence ID" value="ADW69839"/>
        <property type="gene ID" value="AciX9_2816"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2816"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_0_2_0"/>
    <dbReference type="OMA" id="SGIAWDH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005757">
        <property type="entry name" value="Mpl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01081">
        <property type="entry name" value="mpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233488" evidence="6">
        <location>
            <begin position="25"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="9">
        <location>
            <begin position="115"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="8">
        <location>
            <begin position="326"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="478" mass="51554" checksum="B25F6DF17765FAE3" modified="2011-04-05" version="1">MTLMTGKKHIHLIGICGTAMASLAGMLQAQGHTVTGSDAAAYPPMSDQLAAMGIAVMQPYAERNLDVTPDLVVVGNAISRGNVELERVLDERIPFSSMAALLHDEFLVGRESLVVAGTHGKTTTTSMLAWIYETAAKYDAKFAPSFLIGGVAENFGASFMVRATRPFLLEGDEYDTAFFDKGPKFLHYFPDAAILTHVEFDHADIYDDLNAVKTAFKRFVNLIPRRGRLVAYDGNVNVTECVAKAFCAVERYGLAPGSYWRVTGLTADEGGTRWTLERDGEFFAELKLPMPGEHNALNATAAAGLAAGQGVAVEAIKEALATFRSVKRRLEVRAEVNGITVIEDFAHHPTAIRETLRALKASYAGRRLVAILEPRSNTLRRNVFEEALVDSLLIADQVVIAGVFKSESIPEHERLEPEAVAAGLRVRGTPAQVLADAGAIVKVLAPELKSGDVVAILSNGGFGDIYTLLPAELERLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF1</accession>
    <name>E8WYF1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2834</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581172.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2834"/>
    <dbReference type="EnsemblBacteria" id="ADW69857">
        <property type="protein sequence ID" value="ADW69857"/>
        <property type="gene ID" value="AciX9_2834"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2834"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_0"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="380" mass="41049" checksum="9F8A43B780B3210A" modified="2011-04-05" version="1">MSIEGLAGVRFAPVILAGGSGTRFWPRSRRARAKQVLALDGESTMIQQTLERLLPVAAESDVWVITNKWLHDVISAQLPGIKAGHIVSEPIARNTAPACALTAFLLEKQGEADTVIGIFPSDHVVADVPRFSEVIKAGVRLAAAGENIVVLGVPPTRPETGYGYIEQGQGVALGEGSTVSARRVKRFREKPDKHTAERFLTAGNFAWNGGIFLWSAKTLAALVREHVPDMAPILETIAAAFGTADFERVFAEEYPKCENISIDYAVLEPRSSKGEARSNIYCLPADFGWNDLGSWASLHEHLGESDSSNVLDGPTNGLVAIESEGNYVYAPGRMVALLGVDGLVVVETEDALLITTRERSQDVSKVVRQVHEGLGREDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF6</accession>
    <name>E8WYF6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2839</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581177.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69862">
        <property type="protein sequence ID" value="ADW69862"/>
        <property type="gene ID" value="AciX9_2839"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2839"/>
    <dbReference type="HOGENOM" id="CLU_2246177_0_0_0"/>
    <dbReference type="OrthoDB" id="2097231at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="11226" checksum="8A606DF042CA6DA1" modified="2011-04-05" version="1">MSTTRFTTTLNALKEGAKSFTVEKATANIEGWEEYLSKHDHEGVKKVVQDLGKLKKLLHAPELDGEAIKTLIHKLGKDTVAVAGDEETATATHIKELGQALSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP8</accession>
    <name>E8WYP8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0575</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578974.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0575"/>
    <dbReference type="EnsemblBacteria" id="ADW67646">
        <property type="protein sequence ID" value="ADW67646"/>
        <property type="gene ID" value="AciX9_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0575"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_1_0"/>
    <dbReference type="OMA" id="GSKTHWQ"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="195"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="469" mass="53429" checksum="472F92563FEB505D" modified="2011-04-05" version="1">MPDLLLTHGYFLFEDPKEIQIMKPYAPLGILYLCSHLRREGFDVDVFDTTFSSRAALFQHLRTEKPSVLGIYANLMTRGNAVEIMAVAHEAGWRVIVGGPEPGAYAQEYLEAGAEFVVFGEGEATLQELLTALRANADADDPNWKSKIAGAAYLDEAGGFHQNAARAQIADLDAQPWPARHAIDLHRYVETWRTHHQQGSVNFITARGCPYRCRWCSHQVYGQTHRRRDPIKVVDEVEWLMKEYTPDIAWVSDDVFTINHDWIRKYSAEMRRRGLHIPFECISRADRLNEEMLDLLAELGCFRIWIGSESGSQRLLDSMDRGVKVEQVQRAVQMSRERKIQSGMFLMWGYEGEEMEDIEATIRHVSTAQPDIFFTTVSYPIKGTPYYQQIQSKLVQLAPWGKSSDREIKIRGRHSKAYYAHADKLLRDEVQLARISASGAEDDRIIADLSMKISASRQGLLATQCEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS2</accession>
    <name>E8WYS2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1710</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1710"/>
    <dbReference type="EnsemblBacteria" id="ADW68758">
        <property type="protein sequence ID" value="ADW68758"/>
        <property type="gene ID" value="AciX9_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1710"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_0"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="75"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="30987" checksum="22BF9C7B6361734E" modified="2011-04-05" version="1">MNFQSRGMRINNARRTFTNHLVTGLAVLATVMVIAPLVAILIYLFYKGFSSLNVAFFTKIPAPVGNPGGGMANSIVGSGIVLFLSSLMGIPIGIAAGVYLAEFGRGGWLATAVRFTADVLNGVPSIVMGIAVYSLIVMQQKHFSAFAGGVALAIMMVPTITRTTEEMLATVPHAVREAALGLGVPKWRTTFSVALRTASPGIITGCMLAFSRVAGETAPLLFTAFGNQFWSMKLNEPIAALPLQIYVYAISPYDEWHRLAWAGSLVLIVMIMVSVTLVRVFANRGALKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ14</accession>
    <name>E8WZ14_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-phosphate-mannose-protein mannosyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2906</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2906"/>
    <dbReference type="EnsemblBacteria" id="ADW69929">
        <property type="protein sequence ID" value="ADW69929"/>
        <property type="gene ID" value="AciX9_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2906"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_0_1_0"/>
    <dbReference type="OMA" id="STDMQLA"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="135"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="650" mass="73197" checksum="17DB141AEFB21DF5" modified="2011-04-05" version="1">MNEIPQPAESPDPNPAGTGEPQHQARAAWLRHILDHPFVKAPGEIIVLFGVGLFLLLFGLIPHFGGDQIGLVGADEPRYAQVAREMLTAHDQACGAVHATMFPRSLRLQDLENSYHCLTSGTVTPILYGQPWLEKPALYYWRAMSFFREFGVSDWSARLPSFSGAGFLVLLIFLHMRRFRPGGHLDAALITCSCVAIISFSRGASTDMQLAAPFCIGMLGWYAWYETGKKFWLFDLYFFGAAATLAKGPVAPFLALVIIFLFVALRREWTLLRRTIWLPGVILYLVMVLPWYIAVQRRNPTFVRQFILEHNLERFATNRYQHHQPVWYYAVVLLIGLMPWTILGIRALIDAIQISIAEWRVRRKRVRYLGHSRAGDAFPEFLVLWAIFPIVFFSFSGSKLPGYILPSIPPLTILTGDYLYRIRRTGLPPWLRWSHAVLCAILVFILALAPQHMKYETLVPSAPWLIAAGLSAVLIAMLVSWAIRRFGIAQVRNVTLVPVIGSLIFLLGFEGHELDLNYSARPLAQQIAQYAPAGTTLAVLAVKRDMDYGLAFYRNQQPIHYGQDGVPAQEHILVVRSNDQADLDRYLTGRIYKPLFLYESQGLEVYKVYARTTPPPAPIPTLTLPDTTPSDSDSTPPPDTSDDPEPSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ16</accession>
    <name>E8WZ16_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2908</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2908"/>
    <dbReference type="EnsemblBacteria" id="ADW69931">
        <property type="protein sequence ID" value="ADW69931"/>
        <property type="gene ID" value="AciX9_2908"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2908"/>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109402_0_0_0"/>
    <dbReference type="OMA" id="CIAMAIF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="18344" checksum="3D6E95627D340949" modified="2011-04-05" version="1">MRNSSVWGRVSVWLPVVVACLVIVAESTDTFSADHTGGWLRPVLERVFGPLRDETAGEINHYLRKTGHFCGYGTVCLTFLRAWLLTFGALTDLGRRAWRWRAVIAAVACTAFVASMDEWHQSYIPSRTGTVHDALLDTTGAAVSCGLVWLFFWRKQRRGRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD6</accession>
    <name>E8WZD6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1776</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580143.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1776"/>
    <dbReference type="EnsemblBacteria" id="ADW68824">
        <property type="protein sequence ID" value="ADW68824"/>
        <property type="gene ID" value="AciX9_1776"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1776"/>
    <dbReference type="eggNOG" id="ENOG5033SBH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064955_0_0_0"/>
    <dbReference type="OMA" id="WPIDLIN"/>
    <dbReference type="OrthoDB" id="1602656at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230104" evidence="1">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="285" mass="32002" checksum="5189D8A0F63AD182" modified="2011-04-05" version="1">MKMHVAVSLSLLAVPLAIHAEQLVPAGSIIQCTVAEAKISSKTTNVGDPVLCQVSHVEMYGRSTFPYGSYLVGHFEDYKDPGHFVGKGWMELKFDRMVLQPDTVIPISARVVAAPKYNVDKEGRILGNGHPVRDIVEWSIPILWPIDLINLPRRGPSPVLKPESRLTLKLTDDLGIPTPDQIREETLPRRQAALIERQPAPEPVAYEPPRQQYVPQQTYAPQPTYQQQAPQVVYQINPPQPAPIIVQQQPAPQVVYQYPPPPPRYVPYGYYTPVPAAYRYYPPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH8</accession>
    <name>E8WZH8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1819</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1819"/>
    <dbReference type="EnsemblBacteria" id="ADW68866">
        <property type="protein sequence ID" value="ADW68866"/>
        <property type="gene ID" value="AciX9_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1819"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_0"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21212" checksum="314A774D9B615E91" modified="2011-04-05" version="1">MRYPDAMSNTSTPVFPSATTMDILFSREQIAERVAAIGAQISTDYAGQSVVLIGVLKGAAIFLADLARAITVDNTFDFVAVSSYGRARVSSGAVKLIKDIDNPIEGKHVILVEDILDTGLTLSYLRGLMLQHKPASLKIATCLDKPERRLVPIEADYTAFSIPNRFVIGYGMDYAEVYRNLADIRLFPEEVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ5</accession>
    <name>E8WZJ5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="7" type="ordered locus">AciX9_2946</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581284.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2946"/>
    <dbReference type="EnsemblBacteria" id="ADW69969">
        <property type="protein sequence ID" value="ADW69969"/>
        <property type="gene ID" value="AciX9_2946"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2946"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_0"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="13119" checksum="6CAD96927EB4AEB2" modified="2011-04-05" version="1">MADIQNTPATTAPATTEQAATRRNEKVGIVVSTKMQKTIVVEIEMRKAHPKYKRVMKSNKKFYAHDEQNSARVGDVVRIREARPLSKLKRWSLEEIVRRSSLSEPAAAKTDTAVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP0</accession>
    <name>E8WZP0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ordered locus">AciX9_2991</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581328.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2991"/>
    <dbReference type="EnsemblBacteria" id="ADW70014">
        <property type="protein sequence ID" value="ADW70014"/>
        <property type="gene ID" value="AciX9_2991"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2991"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_0"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="32864" checksum="8677CBF94086B7C4" modified="2011-04-05" version="1">MELFGCGTALVTPFRPDGSVDEHALHAHVDWQIQNGVELLIPCGTTGEAATLSDAETQRVIEVTIAAAAGRAPIFAGCTHNSTHTAVQRVSRLSRIPGLTGILTANPYYNRPSQEGQYQHFRAIAESTDLPILLYNIPGRTGANLDPATILRLAEIANVIGVKESSGNLTQITELLTQAPRDFRVFAGDDGLALPVLALGGAGLISVASNVIPAETSDMIRAAIRNDWAGARRINRKIFRLMQALFVEPSPAPVKAVLALLGRSPDHLRLPMVPVTPATRHKLELLIGELGLLTKAPAGYVENLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT3</accession>
    <name>E8WZT3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0674</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579072.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0674"/>
    <dbReference type="EnsemblBacteria" id="ADW67744">
        <property type="protein sequence ID" value="ADW67744"/>
        <property type="gene ID" value="AciX9_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0674"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803546_0_0_0"/>
    <dbReference type="OMA" id="AWINLFN"/>
    <dbReference type="OrthoDB" id="1809344at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="38213" checksum="6A968C530C044797" modified="2011-04-05" version="1">MNVAESVAVSPVPLSAPEPIFNCPECSHWLAPGTLACPDCHAIVYAQHMKAIATAALAEEGEKHWAEAREIWRQGLGWLPAETKQYDAVVERMTLLDGRIRGAEDTKAKWTKRLGPLAPVVFFLAKAKSFLFILFKLKFLLSFVGFFAIYWALFGWRFGLGFTLSILVHEMGHYVAARRRGLKVDLPVFLPGLGAYVRWYSMGINLEELSSIALAGPFFGLIFAVACGAVAKFSVGTTQELFSALAHVTAWLNLLNLIPVFGLDGAQATYALDKMQRWLILASALIFFGLSQEWMLLGVAAGMGWRLWTGDVPEKPGTGTFLRYVLLIFALGIVVYVFPDTTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ1</accession>
    <name>E8WZZ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1840</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1840"/>
    <dbReference type="EnsemblBacteria" id="ADW68887">
        <property type="protein sequence ID" value="ADW68887"/>
        <property type="gene ID" value="AciX9_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1840"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_2_0_0"/>
    <dbReference type="OMA" id="NQESGHY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014870">
        <property type="entry name" value="DUF1793"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032515">
        <property type="entry name" value="DUF4964"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="DUF4965"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="DUF5127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08760">
        <property type="entry name" value="DUF1793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16334">
        <property type="entry name" value="DUF4964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="DUF4965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4964" evidence="2">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5127" evidence="4">
        <location>
            <begin position="138"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4965" evidence="3">
        <location>
            <begin position="370"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1793" evidence="1">
        <location>
            <begin position="553"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="739" mass="82423" checksum="E86D709A6F6D402B" modified="2011-04-05" version="1">MYAVTFAFLEYFLIRNLKLEIHLFIGTASRFTPMVHHSSLRASLLTVALMTTPLLAQELKPIKSSPRPPDTPLIAHDPYFSVWSNSDKLTDSTTRHWTGHPQPLASLIRVDGKTFRIMGRDPGSVPAMEQTAMELTPTHTRYRFAGGGVEVELAFFTPAFLDDLDVLSRPVTYLTWTAKATDGSQHMVSALLDASPEIATSFDHQAVTYSRQKVGSGEVVSVGTRDQAVLNRSGDDLRIDWGYFHLLAPQSEGSQLSISNQPEEVFQATGKIPEVDVMDGVVTTDRFAPHLAAAMNLGTVGTQSVSRHLLVSYTDTYSIQYLGQNLRPYWQRDGKPVATMLDEAARENASLEKRGVAFDQELTGDLTRTAGAHYAWLCTLSYRQSIAAHKLVADGDGQPMLFAKENFSNGDIATVDVMYPSAPLFLFFNPRLLEAQVRPVLQYAAMPNHWHFPFAPHDLGQYPLANGQEYGGGEKTEENQMPVEESANLLILVDGIARTGHTTTLAERYWPQLTQWAQYLKTHGLDPENQLTTDDFAGHVAHNSNLSIKAIDGLGAYADLAKLLHHDSEAKQYSALAKTMAGQWVGMAKEGDHYKLAFNSPGTWSQKYNLVWDKVLDYNLFPPSVRDAEIAYYKTKINQYGLPLDSRATYTKNDWTLWTATLAEKAEDFNALVDPIYLWSTETTSRVPLTDWYDTLSGKQVGFQARSVVGGLFIRALDDKALAEKWRRRSVRESESPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X002</accession>
    <name>E8X002_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1852</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580217.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1852"/>
    <dbReference type="EnsemblBacteria" id="ADW68898">
        <property type="protein sequence ID" value="ADW68898"/>
        <property type="gene ID" value="AciX9_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1852"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_1_0"/>
    <dbReference type="OMA" id="RPFRVGN"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="219"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="643" mass="69850" checksum="5962DC706158CAC5" modified="2011-04-05" version="1">MIVTATRSTIPLGATAKTTYELSSSDLHNYPSPVLDDTLRQHAGFELFRRSSSRTQNPTSQGISLRGLGSTAVSRTLVLEDGAPLNDPFGGWIHWNEAPTSSIDSITIVTGGGSDLYGSSALGGVIDVTPSPIAPTLYELSAIGGSQDTSNIEARADHKFITASGESLHTAGYVITTPASAGLVDVPANVHSESLHTEIGRRAFTTNRFFATGNLFNEARGNGTPLTNNATRLWRYLAGYDTPPEARIPFRARLFGSEEGYRQSFSAIAANRNSENLTRQQRSHTQELGATADATFHTRFLTLVTGADARDIRGLDNEVPYTAGHTNGLFNVNARQRFIGGFAELLAQKGPWSGAASIRVDAAQNLDNHTLTKTLTTSTPATYPNRTEYVPSPRLGLVRTFGPRLNLHASAFRAFRTPTINELYRTGQVGQETTLANPALSSERATGVEAGAQLTSPNHQLQATYFWTEINRPVSTVLLTQTATTITDQRQNLGQIQSRGVEIAATLYRTHPISADIGYQYALATVTSFTPQPKLVGNWIPDVPRQSATAQLHARRPRWGDLTLAARASGMVFDDSANTFILRRFFTLDLSVRHPITHNLEAFALVQNLTNQRPDVSRTPVLTLGSPIFAEAGLRLNFNRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X005</accession>
    <name>E8X005_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580220.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1855"/>
    <dbReference type="EnsemblBacteria" id="ADW68901">
        <property type="protein sequence ID" value="ADW68901"/>
        <property type="gene ID" value="AciX9_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1855"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_1_0"/>
    <dbReference type="OMA" id="FEIYGTC"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="14092" checksum="0F4FF7D5E2C4C893" modified="2011-04-05" version="1">MAIQPRNTKQKEAIRSVFTEAGRPLSHDEALTLSQEIVDGLSIATIYRNINVLVEEKWLSPVEIPGDTTRYEIAGKEHHHHFQCNTCGKLFDLQGCGIEWKAKLPKGFRTTGHEFFVYGLCSTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B6</accession>
    <name>E8X0B6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="11" type="ordered locus">AciX9_3077</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581411.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3077"/>
    <dbReference type="EnsemblBacteria" id="ADW70097">
        <property type="protein sequence ID" value="ADW70097"/>
        <property type="gene ID" value="AciX9_3077"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3077"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_0"/>
    <dbReference type="OMA" id="RKWPLHT"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="417" mass="46832" checksum="CBCD7F0D491E926A" modified="2011-04-05" version="1">MRDTLGVLLAGGAGERLFPLTRDRAKPAVPFAGQYRIIDITLSNCINSDLRHVYILTQYKALSLNRHIREGWGSVVAQELGEFIEILPPMQRVSKSWYQGTADAVYQNIYSIGSEEPKYVIILSGDHIYKMNYAKMLQHHIDTKADVTLATLPILPEEVSSFGVVEVGKNGEVTGFEEKPKETKVRSPFMPDMVDASMGIYIFNTDVLLPELMKDAEDPNSKHDFGHNILPNLLGRCRMQAFNFVDENKQNALYWRDVGTLDAYYEANMDVAGVTPIFNLYDKSWPMRTRAYQYPPAKFVFGEPGRTGMAINSIVASGSIVSGAVVRNSVVSQDVRVNSYADVDSSIVFSHVNIGRHCRIRHAIIDRDVHIPDGTVIGYDQNEDRKNYFVSPSGLTVVTRDYSVYENPVSPEFMQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I5</accession>
    <name>E8X0I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0780"/>
    <dbReference type="EnsemblBacteria" id="ADW67849">
        <property type="protein sequence ID" value="ADW67849"/>
        <property type="gene ID" value="AciX9_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0780"/>
    <dbReference type="HOGENOM" id="CLU_2329810_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="9913" checksum="CD5CB6A0AEACED56" modified="2011-04-05" version="1">MGWTGGFPGWEWFGFGWQVQGKSPGLKPLFLWGFDGGLKAPSNPNGDGNGNGNGNGNGNGNGNGNGNGNGDGDGNCNGDGNCNGNSRCQYGGSELRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N0</accession>
    <name>E8X0N0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1935</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580300.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1935"/>
    <dbReference type="EnsemblBacteria" id="ADW68981">
        <property type="protein sequence ID" value="ADW68981"/>
        <property type="gene ID" value="AciX9_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1935"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395282_0_0_0"/>
    <dbReference type="OMA" id="MEINYFQ"/>
    <dbReference type="OrthoDB" id="163418at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230141" evidence="1">
        <location>
            <begin position="20"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="707" mass="77454" checksum="98D1BD5F239E07A2" modified="2011-04-05" version="1">MRILTLLLTILAMPTLAQAQVVGQNTKPASEGGGVYTLSTSTKLVIEAVNVKDKQGKSITGLTAKDFNVTEDGVTQKVSFAEYQELPTKPDPPEKTKAPENVTVFNRLAVTQIAAETPGSVKYKNRRLISLYFDLTAMPPDDKLRALRAAEKFIRTQMTSADLVSIMRYGGSSVDVLQDFTADHDRLLSIIETLIVGENQQSEDISSDSAAADTGAAFGQDSGEFNLFNTDRQLSALQTAAKMLGRLSEKKVLIYFASGLTLHGVDNQAQLHATIDDAIRSGVSFWPIDARGLVAQAPLGDATQGSPGNTAMYNGTAAFAVTTRLQQSQDTLFALAGDTGGKALLDYNDLALGIVQAQQNVSSYYILGYYTTNPALDGRFRKIKISVNQELAANLDYRQGYYAGKVFAKFTTADKERQLEDALMLGDPVTDLTIAMEINYFQLNRAEYFVPIVVKIPGRELALAKKGGAQHTLIDFILEVKDEVGNNATVQNLRDNVNIKLSDATANELAKRPIEYETGFTLLPGKYTMKFLARDDETGRMGTFQTTFIIPNLNKELKRVPISSVVLSGQRIALTDAIYNAEKAKERAKQDAVNPLVLNGQKLIPSVTRTFSKSRDLFVYLQAYQPGITEPHPLMAFVSFYQQQTKVFETQPMQVTSGMTNSLKTMPLRFDIGLASLAPGEYICQVTVLDPTGQKSSFWETPITLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V2</accession>
    <name>E8X0V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3120</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3120"/>
    <dbReference type="EnsemblBacteria" id="ADW70136">
        <property type="protein sequence ID" value="ADW70136"/>
        <property type="gene ID" value="AciX9_3120"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3120"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048554_1_0_0"/>
    <dbReference type="OMA" id="CERPIPL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="45808" checksum="F512CD9A2141E9C6" modified="2011-04-05" version="1">MKKNSSKNSIPVRLLGCMEEYVWLLEQHSTRMAIVCAEVEGSTTLADWQHALRLLEMKYDVLSTRVKASDGVRPFFCKAEAEGIPLHHRPLTPTSDILTECREVMKTGFGDGGGPPLRVTLLLGANRAAAIFSGHHAFFDGIGLMNLIRDTLSFLTTNNEPSTQEQSPSVDMLVGLDVGSDFLPRNDGSTESRTAPSDVKSASVTSDVPQIGRIELSTELTRAIVVRAREHDTTANGVIMASALSVGRAIGEPWMKNNVTCVVPVNVRPLFHREQAEGIVFGQKRFVFNLLRPPEFWDIARSVSTGVKEVRTRAGLLANLQPLHDFLASQRTVEEAVALASAHTHDLMISNFGTFEEPTQFGQVRLRSLIPVVNSGDENTQTLMVATTADIMTIVLVSPNPLPGYLENLQSHLIKTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W7</accession>
    <name>E8X0W7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3139</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3139"/>
    <dbReference type="EnsemblBacteria" id="ADW70151">
        <property type="protein sequence ID" value="ADW70151"/>
        <property type="gene ID" value="AciX9_3139"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3139"/>
    <dbReference type="HOGENOM" id="CLU_141608_1_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="129" mass="15080" checksum="F082FA9494E1D15C" modified="2011-04-05" version="1">MTEQNEVSEIERLENVRYAAMLSQDVEALDVLLHDRLLHVHSTGNQHTKMAYLSGLKNRDWEYHQIDRSQQNIILQRDTALVFNHLFLRLELKGKAIQLHNQALSVWIREKGAWQLIAMHSGLEPSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X108</accession>
    <name>E8X108_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0806</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0806"/>
    <dbReference type="EnsemblBacteria" id="ADW67874">
        <property type="protein sequence ID" value="ADW67874"/>
        <property type="gene ID" value="AciX9_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0806"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_469912_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="234"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="580" mass="63196" checksum="56A8EC49DE782156" modified="2011-04-05" version="1">MYALVSLDEAPLQQVELDVLGLSAAMSGPHAFASGVAVAAVDPDANALGLLKTSAGITAFAGFLDEPEELAATLGLAAETPAVALALHALRRFGDEAPMRLVGEWSLFHFDLQGRVLTLLSSLAYRDPMHYAIYGQTVAISPDMLTLCRLPGVGRRIDPEGFALSVSRARLRAFMGSRTPWRGVIRVAQGTREIFSAGNRRSIPPAAEPPVTLFRGSFEDAVEASNDVCKRILQQQLRRCGRSAILLSGGLDSTLLNCVGAGVRSADAEMFALTSVAPAGSEIPDERDVSSRTSAFLGIEHRFVSPAPWVSAYIPSATTVNFMQEPMVGLRHYLYEALNAEVVQSGGRALLDGFNGEMSLTRKPARHSQAGWWKRWYRELRDWNALRTQQRVSAGDAFHVRLSAQLLHSLPREWGDLLDARPLAAPAPARGRPFGFNPSLGKMAMLETATAEGIRHVLPYRDMRLLRLAASFPGEFYERPGDTRPLARAMLRGRAPEAVRLNTVARPFSPDYELRIVSQAGDALAHVPGYRMAGVGEWLDLNWLDEALRKIRDHGLVGEHKEAQLACGAAEFLFLLNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X126</accession>
    <name>E8X126_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec-independent translocation protein mttA/Hcf106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0824</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579217.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0824"/>
    <dbReference type="EnsemblBacteria" id="ADW67892">
        <property type="protein sequence ID" value="ADW67892"/>
        <property type="gene ID" value="AciX9_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0824"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480062_0_0_0"/>
    <dbReference type="OMA" id="NIMPPST"/>
    <dbReference type="OrthoDB" id="2060120at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19334" checksum="C023FB4D9A2DF3E7" modified="2011-04-05" version="1">MPSFQDSAFIILLGLLLFGPKGLAGIARQVGKLMGEFRRASADFRMQMEDELRISEQAEQQKKIAAMEAAAPVAPLLHADMPEPEHPHNDVSSMDSLVDVGENRIHLAGDVPEAVAVETPTPLPIASSGDLDLMPPDTGLPVARSGGGSVSGAFDSIPHTADPEVEARHEQQEEHQEAASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X130</accession>
    <name>E8X130_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0828</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0828"/>
    <dbReference type="EnsemblBacteria" id="ADW67896">
        <property type="protein sequence ID" value="ADW67896"/>
        <property type="gene ID" value="AciX9_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0828"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_1_0"/>
    <dbReference type="OMA" id="KANYGPT"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="269" mass="28775" checksum="AA66C9D3656EED3A" modified="2011-04-05" version="1">MADGGMDFDAIKVKQQAAWATGDFAVIGSALLLASELVCEAMDVRSGWRVLDVAAGHGNSSLAAARRGCRVVSTDYVPALLERGKMRAAAEGFRIEFLEADAENLPFGNGEFDAVISTVGVMFAPNQQRAANELMRVCKAGGKIGLVNWTPAGFVGQIFKTIGKYIPPAPGLKPPFVWGTEDGLKELFAGAAKLEIVKRVYTFRALSTEDWLETFKTYYGPMNKTFAALDAGGQAGLRADLLELAGGLNRAEDGTMALPGEYLEVVVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X174</accession>
    <name>E8X174_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1982</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1982"/>
    <dbReference type="EnsemblBacteria" id="ADW69028">
        <property type="protein sequence ID" value="ADW69028"/>
        <property type="gene ID" value="AciX9_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1982"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_230210_0_0_0"/>
    <dbReference type="OMA" id="WARWIEN"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="2170"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2294" mass="240038" checksum="AFDC09737CA3B25D" modified="2011-04-05" version="1">MVNPAATSSSGSYACSISSAYNFYDMQGEAHPLGLAFLSPPEVSVTGGYDPEDHCDSSQLQSNLHSFTSSQSGGDDEVASAAEANCNGLPSENSDCGEGPSFVATDLNGTQYFFPAGQSGVPGYDPHDVTNNYIYPLAIEDRNGNRLAFNVLPNQTNGGLPITDSVGRTIVSVSSSGASAPGAYPYLGTQANQNNSANTMKPLDYNVGGLSYHLDFTSATASYNPPSVRIVNNPGSTYTCNGYFNISEPGFSVLNSITAPNGSAYNFKYDPTFGLVSEVDYPGGGWVRYKWRLSETFSEAANFDGSQGSGSGGQPIPFSGGCLYEYSIPVIDQRTVGYRQGSSAAITQSFSYSTTWNSVGQWLSKTTTVSTTDNISGQKSQTVYSYGPIGRKVQVNEFGLMAVQLPVETSVKDYDLGIAGSSNSTLLRATTKTWSDQYKLTSKTVQLAGAPSSSEVYCFTGDSDLVTEKDEYGFGVSGPQITPVNGGWSVAASANCGSPTPTRKTLLGYGISSMPCLTAIYDGSTRTAETDVYLDGGSSPCLSGSATTQAVGGLVAGTHDEANYGPSVPARRGNPTTVTQWSNNGSSTTTTAVFDETGQIVSSTDGCGNVACADMPGTAGHTTAYSYADNFTDANASGQTNAYVTSVTRPSPNGVPIVLKYGYRYSDGQVSSVTDANNQTTNYTYADSLNRLTETQGPLDASNGNQRPTTAFTYNDAAPSPSITTKMLLNTGGTQLNSVAVQDGIGHTVQTQVTSDPAGTDYVDTAYTGMGSVYSVSSPHRSGFLPTDGTKLFAYDALGREIHQTNTDGSGEWWCYNGISSGSQPNCIGNASSISQGSWVDHSDETGSHWQHVSDSFGRLAAVIEPSPANGTPFLETDYSYDGLNNLKGVNQIGAPGDAPRSRSFSYDSLSRLITSTNPETGTICYGLWSGSTCSGGYDANGNLQYKTDARGKQTSYTYDALNRLHFKTYSDGTPTAAFGYDGKDENGGAIPSSLNSIGRLSHVSNEVNAAKTLSYDAMGRLTSQTECVPSDCSYDIGVSAGYDLAGNMTSLTYPDGRTVQHGFDAAGRMSSVTNLGFSSNVVNQPYLTVATNGYDAAGHLVAAGFGNGVSMGAGYDNRERLLTLGYGPANAPLWSKQYAWTPNSNLQSQTDLITGVQRQFGYDSLNRLTAAQDIFSNLAVASGSNGNTGSTTTSGSGAAETPGGSGAVPQWTNPDDSNLLAELGASQPGWTYTNATVATNAATGPDGLMSAAVVTATSGSQDTYISGTVPNASSYSLETMTGSVWLRSTSGTQTVNLYLVDLSPGNFGIAGWRQVQLTPSWQQYQVTGSMPAALNVISWQIGGGATVSNGQSFMVWNPMLEDEGIAGSSVTNFLPYSQRFSGSTWAANGVSVADNSVTAPDGQKTGATITSTGNGQIDGLVQSPLPYSGLTITGSVWMRVPSGSLSVDLGLYETGSSGFAALNATIVNVTSDWQRFAVTGVTQGSLSLLALQVGGNGHMLAGQVVQVWGAQVEAAATAGPYVATAGIPATINTSFTNLLPYSQTPTGPSWSGQTITTATNSTTAPDGSITAAQISATGADSYLVDSAANPGLYDGATVTGSVYLRSTGGSQTLNLYLFTMNASGRTYFSPQTVNLNSTWQRFQITASLPTGLTALVLQIGGAGSLQSGQVFDVWGAQLEVASHPGPYIATTTLPVLTGTQLTNILPNSQQLNGPNWFLSAGSIAGISGAAPDGTNTASTFVASPNSGDSYLAALAPNPSLYDGETVTASVYLRSNSGTQPINLYLTEIGDQGWQVANSVNLNLSSSWQRVAVTGSLMNGLTNLALQIGGGGSIQNGQGFQVWGPQLVEGSDPAPYTQTTTTTTVIATGQSGTPVPNGLNESYAYDSFGNITKNGSFNASYTANNQMFGYSYDAAGNLLSDGYNVMTWDAESRMLTAGGATYVYDAEGQRVEKQGVGVTDTVYFGGQPIARLSAGQWTDLIYGPNGLLAEVPGTQNGAPVYHVTDQLGTTAGNLLADGTFVNPMDYRPFGGVFSGNTNDPYLFTGKERDAESGLDYFPARYYGSNMGRWMSPDPIPWLGWQHPPEGSSEEEEEESHKKFEEWIGNPQNLNMYAYVNNNPMSHTDPTGMAGCQAGDKKFSTCTITVTYDPKTSKGTLTVTGQNKGDAAPTTLLTASVVVGGDGHVTPTGTFTAKSWEKDHVSTLYGNSANTPWSKTALGGNAFGPYQLHIKELDGRGIFIHGTMGPGWSPTTWGNALFLSPTSHGCIRMCNRDDIDLHSIMPNPAGNKIIIGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C7</accession>
    <name>E8X1C7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiA</name>
        <name evidence="6" type="ordered locus">AciX9_2036</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2036"/>
    <dbReference type="EnsemblBacteria" id="ADW69081">
        <property type="protein sequence ID" value="ADW69081"/>
        <property type="gene ID" value="AciX9_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2036"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_0"/>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="263"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="491" mass="52791" checksum="5F42BAE340338901" modified="2011-04-05" version="1">MSNPLQTAFLVAGNASGVGKTTVTQALIAALQRRGLVVQPFKGGPDYLDTTHHTRLAGRPARNLDTWLLPHEANRDLFTAATQDADAAVVEGMMGLFDGKDPLSETGSSAEIARILGLPIILVLDASKTARSIAATVLGFETFDPTLPIAGVILNRIGGPRHLALLTAAIESRCKTPVLGSLPRTPEITIPERHLGLHAAAQSTETLQAESTLLADLAEQHFNLEAIQSLHQQDFPLPASPSPLVPGPYIPRPSALGPRPCFIGIPRDEAFSFYYEDNLDLLRSAGATLIPFSPLADAELPENLDALYLGGGYPELHAQALSENHSLLTDIRNFAATNRPIYAECGGMIYLSESITQPNTPAIPLTGILPLNIEMTPKLVDFGYVTTTFTRDCLLGPTGTVIRGHSFHYSRLTNEPELNTAYHLDYSLSKRQAPEGYTRGNILASYVHLHFRANPAVVTNLIASIVAARPADSLTLHLEETPQPVAQLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E1</accession>
    <name>E8X1E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulose synthase operon C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2050</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2050"/>
    <dbReference type="EnsemblBacteria" id="ADW69095">
        <property type="protein sequence ID" value="ADW69095"/>
        <property type="gene ID" value="AciX9_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2050"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001631_1_0_0"/>
    <dbReference type="OMA" id="YGQGGYF"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008410">
        <property type="entry name" value="BCSC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003921">
        <property type="entry name" value="Cell_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05420">
        <property type="entry name" value="BCSC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01441">
        <property type="entry name" value="CELLSNTHASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BCSC_C" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1721" mass="185806" checksum="46D086E0D2655F91" modified="2011-04-05" version="1">MAAQIWQQVLLVDPNNTQALAGLARAAKLKGDLQVSANYVSRLRSLSPNDPAIAEVESMQTQQNKNTVLREAGHLAEQGEYAKSLELYRQAYGNNPPPGEGAVGYYETESALEDRRGDAIAGLRRLVAQNPQDTHYQVALGRILTYDPRTRAEGRRLLEAHPYDPGAVDALRQSLLWDAKNPASAAQIRAYLSSHHDEQLFDALRDAPKYGGGGRGRPLTPEQRAEQALDRTRTREDRSAYRALNQKHLPEAERLFKEILAKHPEEANALAGMGYVRMAQANFAGAITYFSQAQQDGSKDPRIEGALRTSRFWNTMAEGALDLNDGNLPGAEKNYRAALVMWPNRPEALEGLGGTLLRAQQPAAALTIFVQYVKVAPAAPHAWRGLFLAEMGLGDATKALQIEHDLPPTVRAELSHDPLFLRQLSSAYAAVGRDGDAARVLKAALDLPFSVDQKGLEADEQIQYAGLLQEANHLQQAAGLYRQVLAKHPNNTEAWEGLVRVEHAQDHDEEALRTLESIPQASYAVAIKDPGFESTMASIYQSQKRYDVAQKILEDAIAQETAAGQKPSVAVQIQLAGIYLLRNNPQQAYPIYHQILTENPDRLAAWNGLLSSLHQSGRDKEALSEVRQIPAKTRATLEQDVSYLQTVGAIYTALGDPKDAEIFLRRVQHHYAEQRALAPADVDIQNAWLLYNGMNDAGLYRQLMVLGDRNDLTEVQRRTVQTIWTNWAVRRANQSSAAGNDHRALAILNATARAFPDNPEVIKALANGYSHAGMTKQAVMIWKAQDLNNASSADYQAAIGAALAAQDLGNAEKWLRFALNLYPTDSHILVLAAKFEEARGDTNRAADYYKASLEAMPAVDPGAELATELSRPVPIAAVGLPNPNSQDLAGLLAPNGTDQNVSQGGGAVDTAPYLPGYGNLSGPAPVPLGGMDDAPSMPSTPPSDYGNGRPAVPSYMTAPRKTAPADGSKPRLKDYVPQASSEAPVPMDGTETPRIQYASNESATKMVLMPAVYQPQQISREAEQRPVLRYASYEVPQQQSAPAQSTQTTQTQTGMQPPPATGDQGYGTYVPYKAPAATQTQAPPPQQSAPPVQQQVGTPTAPADERFGPYVPYKAPAPTAVQLGTPEPAGATTSQPQVTDVLPTSHQTPAARTTRNARRRQAAPANATGQSVPPPAGNYGQPSGDQVAQPGTSGRQLTYPEPTNAGGQFPQQTGGSDGQQYPQPNTAGTEVYRGRLHGRRRPATTAAKAAPPAEQPAYQGLNYPGIGQPLSYQPYPLIGPGYPLGVPPSDGDLLERELPPLRGPYYHGEALKPELTEREQAELALNTLEGSYSGWLGGTGSARYRSGTPGVDRLTDLTATFEATQTIGNNVRLSIVPKAVFLNSGTLDTANFTTTNPVLGTLPGNAVNPPQQQFANGVGGELQLSTRTFAAAVGYTPYEFLVRNVTARVLWAPTRHFTLFGDRSPVTQTQLSYAGLRDPGSATPIFAGNVWGGVISTGGGARLDFGNEKAGFYITADGADLTGVHVLENTTFEGSMGAYFLAHTFPGYGRLNIGASMFGMHYAHNERIETYGQGGYFSPDAYFLASVPITWAGRYGSNFHYTVAGSLGVQTFQEDNAPYFPLDKTLQNALTCTLGQLTTRTGCIIPQNSNTGGNYSINAEGAYKISEHWFGGGFLSANNTNDYNTVTGGFFVRYLFRPQYGADDYPTGLFPVEGFRPLRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F6</accession>
    <name>E8X1F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581503.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3180"/>
    <dbReference type="EnsemblBacteria" id="ADW70191">
        <property type="protein sequence ID" value="ADW70191"/>
        <property type="gene ID" value="AciX9_3180"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3180"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_3_0_0"/>
    <dbReference type="OMA" id="EAWVEKK"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="35324" checksum="A65666A0886B12C0" modified="2011-04-05" version="1">MSFQLILPFFPEELRALLLDPSISDLMINGTTGVFADRAGVVEHIPLASEYTNDRLQAAIERVARILGQDLTSQNPILNTRLPDGSRVAVVGSPSSINGPTLTVRKFNRWYTTDELVQAGSFPSIVRDDVVNLILKRKNGIISGGTGSGKSTLMKALLDHVPMYERLVVIEQPAELKVAHPNAVRWEAVAAIPGQVAISPSQLVAAALRHRPDRIIMGEIRDESGYDLLQAMNTGHGGTMATLHADSAVDALDRLADMALSARTNLDQTFVRSQTGRAVDFVLHCERDHKGRRRVRELITVSGYSHAEQRFLTEDIYRAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H5</accession>
    <name>E8X1H5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3199</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581522.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3199"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="ADW70210">
        <property type="protein sequence ID" value="ADW70210"/>
        <property type="gene ID" value="AciX9_3199"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3199"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_1_3_0"/>
    <dbReference type="OMA" id="VAKPFYI"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="31"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="30363" checksum="F032FED57D970895" modified="2011-04-05" version="1">MQTVETTNDPALEPLAAQNEAEPEIRKENLAEAIASIATVLVVGLFVMTFIAQNFVIPSGSMEKTLLVGDHVLVDRVTFAPETRWAPFVHYRDIRRGDVIVFLKPNPETPDMVLVKRAIGIPGDHIHLQHGTVYLNGVAQDEPTAAKVRSDGDADDAYQPARDDFPANGAPAGSTEVWNEDLASHIQNGDLVVPPGKVFAMGDNRTHSLDGRFWGFVPRENILGRPLFNYWSFEANSDEMEQEAGMGTRIGSLGHTALHFFDKTRWKRTLHLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I5</accession>
    <name>E8X1I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3209</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581532.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3209"/>
    <dbReference type="EnsemblBacteria" id="ADW70220">
        <property type="protein sequence ID" value="ADW70220"/>
        <property type="gene ID" value="AciX9_3209"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3209"/>
    <dbReference type="eggNOG" id="ENOG5032FP2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480064_0_0_0"/>
    <dbReference type="OMA" id="RIGWIPW"/>
    <dbReference type="OrthoDB" id="1976201at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19903" checksum="6F04D1D3D06F7C3E" modified="2011-04-05" version="1">MVGKSPGRIYLGSKRGRMERREFFSKKLKLIGWLCVAVAFAAGGFYEVRVGDGPEQAGGWLCLVVCALGGVVLLKELLSSGPKMVLSGEGLFDRSLGTPVIPWQSILEVDISHVKKSGYITVRLADEAQRVANLPIQKRAMAAWNKKLGGDVFNTSISTLDVPPEGVVSEVVKQWHYYAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q7</accession>
    <name>E8X1Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0909</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579300.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0909"/>
    <dbReference type="EnsemblBacteria" id="ADW67976">
        <property type="protein sequence ID" value="ADW67976"/>
        <property type="gene ID" value="AciX9_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0909"/>
    <dbReference type="eggNOG" id="ENOG5032WCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136111_0_0_0"/>
    <dbReference type="OMA" id="LSGWRYD"/>
    <dbReference type="OrthoDB" id="1879119at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18285" checksum="EFA830D65CBBAC21" modified="2011-04-05" version="1">MNPDRQISNESSRAARAGSCTDPVVGAILAGWRYDISSISPEMRTDYEQHLFECAHCKHRQRAARTIDVLLLMVSTLSILAFLLAAVVIRRIEILTHIDSVHVHLRQTAVAISLEAAAIAGLVVSTALWILVAVATPLPGYLTGVVQQRLPSDLRQRFSRHAQNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W1</accession>
    <name>E8X1W1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2077</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580439.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2077"/>
    <dbReference type="EnsemblBacteria" id="ADW69122">
        <property type="protein sequence ID" value="ADW69122"/>
        <property type="gene ID" value="AciX9_2077"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2077"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393765_0_0_0"/>
    <dbReference type="OMA" id="GMIQTRW"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234088" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="147"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="732" mass="80726" checksum="7CD9B47B33EA86D0" modified="2011-04-05" version="1">MRLSRLATCALFLLPSLAFSQTLHLIPMPREVHASTDVPLAQGIRITTSTQDPEDRFTAEDLTTSLAARAIPTSGPFTINLTRTQSLPEEMKLEGYTITPGQNSITLAAASSAGLFYAAQTLKQLIEHDGSAAVLHLATIKDWPAMRYRGYQDDLSRGPISTLEYEKKMIRTMASYKVNLFSPYFEETQQYASNPTMAIPGASMSAADARELVAYATKFHVMVVPDQEAFGHLHHNLLYEQYQPLAETPHGTALAPGQPGSLALIHQMFGELAALYPSPFLHIGADETVDLGVGQTKSAVDTQGLGPVYLNFLQKIVTDLQPLNRRILFWGDIAQTIVQGKTAYGSVGAPGNDHPDPDLIKNLPASFKKGTIAVAWWYNPNPRGGFSKFLTPFTDAGIETWVATGVNSWSRIFPNNNDALANIQQFTLEGQRQHSTGQLNTIWYDDGEALANGNWYGLLFGAEAAWHQGEASIPAFEQSYAQVFHGDATGKLNEAQLELMECHRILRDQAHVGDGSTGIFWSDPWSKDGQPNAAKIRPYVHDLRMHAEHALTLIAQARAAAPPLTVGAPRLASETWDHAAYDPLNAYPSNPTALRNTDAIDALELGARRFDFIGLKFQLSDEIIQGYNRALIARASSDPKLHATTGREIGDIASGVNGRIRDLRDNFSLIRDLYEQTWLRSNRPYSLRPVLEKYDASIQLWIARGEKFRSAQRQYGESKTLPTAFDLGLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X0</accession>
    <name>E8X1X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2087</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580447.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2087"/>
    <dbReference type="EnsemblBacteria" id="ADW69131">
        <property type="protein sequence ID" value="ADW69131"/>
        <property type="gene ID" value="AciX9_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2087"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_1_0_0"/>
    <dbReference type="OMA" id="RLWRIPL"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233596" evidence="1">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="43"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="410" mass="44263" checksum="43889CC0FF0E2F0F" modified="2011-04-05" version="1">MKHLALAGLFLTMVSTSASAQVNAGDQKSDSVLPFTVTQVTTLSLPWKIAFLPDGRMLITEKTGGMQLVTQQGEKTPVSNVPAALWRGQGGMLGVYLSPHYAKDHFVYLTYSEPGDGGSSLALARAILKLDKGTASLEDLKVIWRDGERGQGGQFGAEVAFSPDGKLLYLSSGDRQRMTPAQDPNQPLGKILRLTLDGKPAPGNPMAGKIGTPTVPVIDPPEDTEAAKTAPVVKTYTFPGPNLTPSETWVTGLRTPYGLAFAPDGRLWELEHGPRGGDELNLIEPGKNYGWPLFSYGKNYNGVPIPKTDPKPNLTEPVIYWDPVIAPGNLAFYKGSMFSQWNGSALVSGLGPKILMRLTFDSKGGAKVAERWNFNHRLRDVEVAPDGAIWVIEDAKPGALWRLTPKTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X9</accession>
    <name>E8X1X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2096</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580456.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2096"/>
    <dbReference type="EnsemblBacteria" id="ADW69140">
        <property type="protein sequence ID" value="ADW69140"/>
        <property type="gene ID" value="AciX9_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2096"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="VANAKEP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="507" mass="55609" checksum="5D4C99A5D4AAE52C" modified="2011-04-05" version="1">MQTGPVEVAEMSGDVAVLKTGVGILVQDAMSRRLIEAASIHLELQPVELDEGSFEGSMLSGFELIIADEAIALRLRAVMTTGDEQAEGVNPALIAVRSKTAVGPEEPEVHFEGVLALPQEPAAIVAQMGLILYAHRAFARRYQSALEELQLNRRIFRSVTSGISVANAKEPDLPLVYVNPAFEVMTGYSLEEVQGKNCRFLQKGETEQPGLTLIREALAAGREVVAILRNYRKDGTVFWNELSLSPIRNRDGELTHFVGIQNDVTSRVEFEAALRESEKLAAVGRLAASIAHEINNPLESVMNLLYLAGHGSDDEAKGEYLAQADKELQRVAQITSQSLRFYKQSTKPQAVRLVDLMESVLDLYQGRIENAGLTVKKRERMTESIVCLESEIRQVLSNLVRNAMDSMAGTAGRLMVRTREATEWRSNTRGVLLTVADTGTGMSPETLKKLYTAFYTTKGIGGTGLGLWVSAEIVQRHKGRLLVRSSQRAGASGTVFELFLPYQGFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y5</accession>
    <name>E8X1Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2102</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2102"/>
    <dbReference type="EnsemblBacteria" id="ADW69146">
        <property type="protein sequence ID" value="ADW69146"/>
        <property type="gene ID" value="AciX9_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2102"/>
    <dbReference type="HOGENOM" id="CLU_2301869_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="10124" checksum="1513380571944936" modified="2011-04-05" version="1">MVGRAGAKARVYGGFDGGLKPTSNPNSNSNSNSNSNGNGNSNSHSHSHSNSNSNSNSNSNSNSNSSSNSNGNSHSHSRSNSNSHSHSNSKGQCGDTRSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X280</accession>
    <name>E8X280_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579336.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0945"/>
    <dbReference type="EnsemblBacteria" id="ADW68012">
        <property type="protein sequence ID" value="ADW68012"/>
        <property type="gene ID" value="AciX9_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0945"/>
    <dbReference type="HOGENOM" id="CLU_2584806_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="9162" checksum="FBE8E0B475142935" modified="2011-04-05" version="1">MKMGKFVFGRAVLWILVALLLGGGYARRIWEFRSAGLPLGWAPYTFLAVWIAVLVFWLVAAVRQWQGRAEVRKNAERKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X286</accession>
    <name>E8X286_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="11" type="ordered locus">AciX9_0951</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579342.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0951"/>
    <dbReference type="EnsemblBacteria" id="ADW68018">
        <property type="protein sequence ID" value="ADW68018"/>
        <property type="gene ID" value="AciX9_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0951"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_0"/>
    <dbReference type="OMA" id="WDAGFEF"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="44354" checksum="A2C90F05CA1E7552" modified="2011-04-05" version="1">MATQNKDYYAALGIKKGATTDEIRKAFRKLARKHHPDVNPGDKKAEEKFKEISEANDILSDEKKRKIYDQLGFYSDNIDPAAAEAASRGGYGGNPFAGGAPPRSGGRGSYGGQEVPFDFGGFDFTDFQQQPGGGSAKQNEGAGFGGSFKDIFSGMFNGGGGGKTAQRGPQAGTDLEYQVSIDFWTAVRGGTTRLEIQRQEACPTCKGKSTTGGAMECPECSGSGQVTQMGGRMKFNIQCPRCGGSGQVQNSCATCDGAGVVTRREPLEFRIKPGTRDGQRIRLAGKGNAGINGGGNGDLFLIIKIGSHPVFTRTADDIYATIPVTLMEAALGAKIDVPTIDGRSQLRIPPGTQNGQKLRLREKGVPSAVNEGLRGDQIVEVKIVVPKIQDERSKEILRELAKLNPDDPRAEMLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D0</accession>
    <name>E8X2D0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha subunit</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0995</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579386.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0995"/>
    <dbReference type="EnsemblBacteria" id="ADW68062">
        <property type="protein sequence ID" value="ADW68062"/>
        <property type="gene ID" value="AciX9_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0995"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_1_0"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="23379" checksum="697A30D8D2C680E0" modified="2011-04-05" version="1">MFTGLIETTGTIENVTHSTSGPVRITVACPTLAARLETGDSIAVNGVCLTALDLSETHFSADLALETVERTTLSRLQPGTTVNLELPTPAGSPLGGHVVQGHVDGVATLLSLDPIDPTNEETSDWRLRLLLPATLARYVVPQGSITVEGISLTVADFTDDVVSIAIIPHTYKATALHTLAPSDPINIEVDVLGKYAEAQKENRPQPGWTVTEEYLLANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F4</accession>
    <name>E8X2F4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">AciX9_2134</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2134"/>
    <dbReference type="EnsemblBacteria" id="ADW69178">
        <property type="protein sequence ID" value="ADW69178"/>
        <property type="gene ID" value="AciX9_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2134"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_0"/>
    <dbReference type="OMA" id="CGPRITL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="10971" checksum="D62767A928EB0EDC" modified="2011-04-05" version="1">MAEVAGHTDRETLIRSMSELVAGMAKALVDSPEGVSVKVETDGDSTVLVLRVAASDLGKVIGKQGRTARSMRTILGAASMKAHHRFALDIQQVDQLEPPTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J7</accession>
    <name>E8X2J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cl-channel voltage-gated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2177</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2177"/>
    <dbReference type="EnsemblBacteria" id="ADW69221">
        <property type="protein sequence ID" value="ADW69221"/>
        <property type="gene ID" value="AciX9_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2177"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_1_1_0"/>
    <dbReference type="OMA" id="NPYYRVL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="46650" checksum="AC66A6E64E1AAFBA" modified="2011-04-05" version="1">MLKIRQTTSEQLSLLIELARWISISALVGIMGGSASALLLISLNYATDLREKHVWLILFLAPAGWLVGEMYKRLGTSVEAGNNLILEEIHSPTATIPVRMTPLILIGTFMTHLFGGSAGREGTAIQTGASLADQLARPFRLSPRDRRILLMAGISAGFASVFGTPLAGAIFGLEVLAIGTLSYEAIAPCFMAAFVGDLVTRAWKVHHTVYTVTDVPTMSIRGVAYAMIAGAIFGLAGMCFARLTHAVSHLAKKYIVNPPLRPVAGGLLVTIAVFGLGTSHTLKYIGLGIPTIVAAFHSRLPAYDFAAKSIFTAITLGAGFKGGEVTPLFFIGSTLGNALSRLIPLPSSLMAGMGFVAVFAGAANTPIASTLMAVELFGGEAGAYAGIACVISYLFSGHAGIYSSQRVGQSKHLSRAEEEGLPLTLVAKMHDAPEENTAPLHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K3</accession>
    <name>E8X2K3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2183</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580543.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2183"/>
    <dbReference type="EnsemblBacteria" id="ADW69227">
        <property type="protein sequence ID" value="ADW69227"/>
        <property type="gene ID" value="AciX9_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2183"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_0"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="32910" checksum="0AA45C3041EDD72D" modified="2011-04-05" version="1">MILIVAEQGNGKLSKSTYEMVTAARECGREGPVTLLVLGSGVVQVAAQAALLGDQVLVADLPALEQFDPEVWAAAVAQIAKEGEAHTILIGGSRSGRGYSSRVAVKLDAPLVEDAISLKYAGDVLEAEHYTYLARVTERVQALAPVIVATVKPGAFAPAQAGAEAVEQFDVELELPSKRVEVTERATAKSERVSLTEADIVVSGGRGLGSAEAFTELVEGLADQLGAAVGATRAIVDAGWRPYAEQVGQTGKTVQPKVYIAIGISGAVQHLSGMGKSKVIVAINRDRDAPIFGMADYGIVGDVKEIVPAILAKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L1</accession>
    <name>E8X2L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2191</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580551.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2191"/>
    <dbReference type="EnsemblBacteria" id="ADW69235">
        <property type="protein sequence ID" value="ADW69235"/>
        <property type="gene ID" value="AciX9_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2191"/>
    <dbReference type="eggNOG" id="ENOG502ZGEH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1967451_0_0_0"/>
    <dbReference type="OrthoDB" id="2100517at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="14508" checksum="CB93E6C8D612D6BE" modified="2011-04-05" version="1">MNVSAVKAEPVGPTLMQDHIPVPLNLKNTMFVERRRTMRRGNMEQGRALEMLGHAVEYLVDSRLFGVDERTVKSNQEAVQILMRLSRAVFSECPEVVPVGRKFNLWMRGMVDKVIGEPVRGGKTERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P6</accession>
    <name>E8X2P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581655.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70343">
        <property type="protein sequence ID" value="ADW70343"/>
        <property type="gene ID" value="AciX9_3335"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3335"/>
    <dbReference type="HOGENOM" id="CLU_2954055_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6689" checksum="767476826CBF91DB" modified="2011-04-05" version="1">MKLVYIGGYYINPNNVMYVSRRFSQADPKKPLAQVHFVNGAVLDLEMNPSECAQELEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X328</accession>
    <name>E8X328_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2208</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580568.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69252">
        <property type="protein sequence ID" value="ADW69252"/>
        <property type="gene ID" value="AciX9_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2208"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_0"/>
    <dbReference type="OMA" id="ASTDHWR"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="273" mass="30124" checksum="5EB442D93FC1623E" modified="2011-04-05" version="1">MQTQDKSVVVGGVRVHYQQCGSGPALIMVHGLVGSARNWDQNIEFLSRDATVYALDLANMGESERVRGLDAGMAATADRVAAFMDALGIVDADVAGHSHGGAVVMMLAARHSERVRKLVLFAPANPFCELCRGLVKFYNTRVGQTFARIIPRLPRLAHDVAHRRMYVDKRRVTPEALASYTDGLNRESVEHMLGILRQWWSDMGVLRSRLAEVAKVPTLLIWGDQDFAVGVRSGERLAEALGARLMVIPNVGHLPFAERPEVCNAAMREWLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q4</accession>
    <name>E8X3Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2294"/>
    <dbReference type="EnsemblBacteria" id="ADW69332">
        <property type="protein sequence ID" value="ADW69332"/>
        <property type="gene ID" value="AciX9_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2294"/>
    <dbReference type="HOGENOM" id="CLU_2436670_0_0_0"/>
    <dbReference type="OMA" id="TIGIEYD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10134" checksum="6A4E762A22EE1A5F" modified="2011-04-05" version="1">MYRYGSVPTEAATLALGAMREVYGIRRMEFKELEQTVRVEYDSTRLTEAVIYQLLRRTGLDISEQLALTVPAPPPPPPAPPAAPPAAPVAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X469</accession>
    <name>E8X469_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_0038</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578458.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0038"/>
    <dbReference type="EnsemblBacteria" id="ADW67129">
        <property type="protein sequence ID" value="ADW67129"/>
        <property type="gene ID" value="AciX9_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0038"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_0"/>
    <dbReference type="OMA" id="TYPRVDT"/>
    <dbReference type="OrthoDB" id="100725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13342">
        <property type="entry name" value="Toprim_Crpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="714" mass="78927" checksum="E7077A969373CA40" modified="2011-04-05" version="1">MRVFLAEKPSVAREIAQALGCTHKEQGFFRGKNDLVTWAIGHLVRFAEPGEMNPAWGKPWRREALPMLPKDGGWLLIPEPRTEDQFNVVARLFGDKRITQIVNATDAGREGEAIFRRIYALSGASKPVLRFWTSSLTEEAIASALSHLRPAADYDNLASAALTRAQLDWLIGMNHSRAATLHNSVTCSVGRVQTPTLAMIVRRHHEIAGFIKTFFYEVHADLGEFVARAVNSQQKHDFEIKAEAETILRDVPSDTLATVTLVEVKKNRKAPPQLHNLGELQKEANRRFGFPADRTLAIAQSLYESKAITYPRSSSRHLSEDMVDGLPAVLKALRLGEERASYVKQALHRAQHGPALSKRFVDGSKLSDHHAIIPTAKPAPASLSGDERKVYTIVAERFLAIFLPDKETEDTRIDLEIAKHPFRARGSRLIAPGWTVLTGNQDFENKAADAEDRQALPAVKKGDELEVVESELVTKERKPPSRYTDATLLAAMETAGREIDDDELREAMKGRGLGTEATRAAIIQRLLDLAYVIRDGKQFEPTGKGIALIAQVLPHLASPELTGDMEAKLNLVEAGQLDAAEILAEVSESLRHEIPAVFRSKPMQAPDAPRITAGKDELLCPKCKAGLVTKRSTPNASAPFYGCARFHDGCNFTINTVVAKKTLTETNIKDLCSPTRHHTTKIIKGFTSKAGKKFDAFLQLSSATDFKTEFVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X493</accession>
    <name>E8X493_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0062"/>
    <dbReference type="EnsemblBacteria" id="ADW67153">
        <property type="protein sequence ID" value="ADW67153"/>
        <property type="gene ID" value="AciX9_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0062"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_5_1_0"/>
    <dbReference type="OMA" id="HPITPEY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="12169" checksum="C915637802938486" modified="2011-04-05" version="1">MDYRVRLMPRAERDLEEIFQYIQARSSSAAHSWFMRLTNAIDGLSTFPQRHPITPEYPSLRHLLFGNKPHIYRVIYLIDVTARSVDILSVWHGAQQPFTREIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M5</accession>
    <name>E8X4M5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ordered locus">AciX9_2398</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580751.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2398"/>
    <dbReference type="EnsemblBacteria" id="ADW69435">
        <property type="protein sequence ID" value="ADW69435"/>
        <property type="gene ID" value="AciX9_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2398"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_0_1_0"/>
    <dbReference type="OMA" id="RFPVKYY"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6 8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15307" checksum="3977725333660E7D" modified="2011-04-05" version="1">MQTYPYLWQYLPLVLQIVVAIALAGGMVGASFFVGKHKNSRTKAGTYECGMDPVGDSRGRFSVRFYMVAMLFILFDVEAVFMLPWAVIFRKLPGLGYSKYFGFNEMLVYLAFVGVGLFYVWKKGILNWANDKGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T0</accession>
    <name>E8X4T0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3565</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581880.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3565"/>
    <dbReference type="EnsemblBacteria" id="ADW70569">
        <property type="protein sequence ID" value="ADW70569"/>
        <property type="gene ID" value="AciX9_3565"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3565"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_1_1_0"/>
    <dbReference type="OMA" id="DEYLFPW"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="28747" checksum="D5260B19E80E660A" modified="2011-04-05" version="1">MRALILSDIHGNLEALEAVLFAAEGKYDEIWNLGDMVGYGASPNQVIDRIRPISAVVVRGNHDRVCCGLTSPNGFNPVARAAALWTRAELTPENLDWLRNVPQGPISPNFEGITCAHGSPLDEDRYILTMRDAWAPLQQSPAPITFFGHTHIQGGFSQRDHNWHDLRPAYERRTDTRSEPVQWTLPLEPETRHLINPGSVGQPRDHDWRAAYAIFDSEAAEIVFHRTPYDVMTTQGRILMAELPERLASRLREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V5</accession>
    <name>E8X4V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3591</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581905.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3591"/>
    <dbReference type="EnsemblBacteria" id="ADW70594">
        <property type="protein sequence ID" value="ADW70594"/>
        <property type="gene ID" value="AciX9_3591"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3591"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148789_0_0_0"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15331" checksum="9617DD3DE20DF7D1" modified="2011-04-05" version="1">MSNTIQSAGPNPTNNSEIEVYPGWVASGQDNTPGRKAYYINLEAKPGKGDQVQQFLKDILAGVEQEPGTGPWFGCRFSDTTFGIFEAFPDVAARNAHNVGPGGQNFLRAAELEEMLAHPAHVYRLDVMFGKFSVLFGKPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W0</accession>
    <name>E8X4W0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70599">
        <property type="protein sequence ID" value="ADW70599"/>
        <property type="gene ID" value="AciX9_3596"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3596"/>
    <dbReference type="HOGENOM" id="CLU_1862357_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234377" evidence="2">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="14694" checksum="5B4829EF6DD235B0" modified="2011-04-05" version="1">MKDFGAKLTLILTFFAAALLLMAACYAQPGPLPDGPGGGPPTVEQELARMTWALALSEAQGRAILPILEDRHYEVGALMRNGAGREANEAQVHAIFEETDGEIKVLLAEEQQAIFDAMRPPRPPDGATARVDRIAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X567</accession>
    <name>E8X567_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1269</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579654.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1269"/>
    <dbReference type="EnsemblBacteria" id="ADW68331">
        <property type="protein sequence ID" value="ADW68331"/>
        <property type="gene ID" value="AciX9_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1269"/>
    <dbReference type="eggNOG" id="ENOG5033B8R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135628_0_1_0"/>
    <dbReference type="OMA" id="GFRTHRR"/>
    <dbReference type="OrthoDB" id="1899465at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015097">
        <property type="term" value="F:mercury ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004891">
        <property type="entry name" value="Mercury-R_MerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03203">
        <property type="entry name" value="MerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16659" checksum="7F911550EFEF35A4" modified="2011-04-05" version="1">MFTQASSQSHIQPQTSAWPDRLGVYASAACILHCLITPVLLSLSAVFAHLLPSEERTHRTLALLVALLGVIALIRGFRTHRRRRILILMAAGLACIFFAAFAGDSLPAHWYEVAITFLGSAFMIAAHRLNHTFCRDCACTRSTLIPCTLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D9</accession>
    <name>E8X5D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2451</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580802.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2451"/>
    <dbReference type="EnsemblBacteria" id="ADW69486">
        <property type="protein sequence ID" value="ADW69486"/>
        <property type="gene ID" value="AciX9_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2451"/>
    <dbReference type="eggNOG" id="ENOG5032RYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168334_0_0_0"/>
    <dbReference type="OMA" id="ATILCAH"/>
    <dbReference type="OrthoDB" id="1825065at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="10938" checksum="10741B7C883D1D00" modified="2011-04-05" version="1">MPGFLMHQGATVLCSHGGQAQPTVPNPRVVVNGMPTVPLSGPWVVAGCAMPPPPAGNGPCITAQFVAGTTRVLSNGLPLLTFDSQAICTPTGTPTITILTQTRVFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E2</accession>
    <name>E8X5E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580805.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2454"/>
    <dbReference type="EnsemblBacteria" id="ADW69489">
        <property type="protein sequence ID" value="ADW69489"/>
        <property type="gene ID" value="AciX9_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2454"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146747_0_0_0"/>
    <dbReference type="OMA" id="QWWRIAD"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11689" checksum="3B686CC76A6F0FAF" modified="2011-04-05" version="1">MFDSASRYNGVSLLPYDTADGRTVNYVARRFLPRPDNYDLLLLHTVTEGDRLDNIANTYLDDPQQFWRICDANECVSPFDLTEQPGTRIRITLPQGIPGPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H1</accession>
    <name>E8X5H1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2485</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580834.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2485"/>
    <dbReference type="EnsemblBacteria" id="ADW69518">
        <property type="protein sequence ID" value="ADW69518"/>
        <property type="gene ID" value="AciX9_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2485"/>
    <dbReference type="eggNOG" id="ENOG50332GQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134478_0_0_0"/>
    <dbReference type="OMA" id="LEINFAI"/>
    <dbReference type="OrthoDB" id="1992778at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18300" checksum="7B3C842C47E092A8" modified="2011-04-05" version="1">MMNKEVLMITGIEGAGNLAAAIGEQLDLHVEVAATRKAALTSLKHGEFGVVIVEENMAAMDPDWANHVWAHAGQAIPLEINFAISGVSRLTREVRSALDRMKREQLLARRSVALEMENDLKVTVTGMLLQSELALREPAVSPTLEPKLRRLVELAGVMRERLRVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N8</accession>
    <name>E8X5N8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3664</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581974.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3664"/>
    <dbReference type="EnsemblBacteria" id="ADW70665">
        <property type="protein sequence ID" value="ADW70665"/>
        <property type="gene ID" value="AciX9_3664"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3664"/>
    <dbReference type="eggNOG" id="COG4654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151358_0_0_0"/>
    <dbReference type="OMA" id="IQMPPHH"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011429">
        <property type="entry name" value="Cyt_c_Planctomycete-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07635">
        <property type="entry name" value="PSCyt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="14442" checksum="602951CD075FFA2F" modified="2011-04-05" version="1">MLRFGTGLGVAAMLFMAWGLGGVKAQDDASKPEFYTTKVKPILETNCAKCHMGINHRGGLNIDTRAGMLKGGHDGTVLVPGDADKSLLVRLIRHEGPKDDPMPMPPNKPKLSDADIAVVAQWVKAGAVMPLDAVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S5</accession>
    <name>E8X5S5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572721.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70809">
        <property type="protein sequence ID" value="ADW70809"/>
        <property type="gene ID" value="AciX9_4013"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4013"/>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_0"/>
    <dbReference type="OMA" id="IHEWPYL"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="200"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="421" mass="45623" checksum="42464ED31F0E08DF" modified="2011-04-05" version="1">MDRRHFLQTSAALTLAPLAQAQRTAPAESGPLPPAIAALKNRKSEAIPITLAEREHRFARAQELMAQNGMDAILLVGGTSLLYFTGIRSGNSERLFAFILPRKGEAFIVCPAFEKDRMMERMDSVPGGKSTRIYTWQEHESPSALVGKGLGGTGTLGIEEKTPYIYASEIAKANPHLKLVDATAVTAGCREIKSPAELALMRLASSVTLQVYEAVFTAAHPGMTTRDFSNLCAAAYQRVGFQGDASCQTGIYSALPHGSLTPQIIKENEIVLIDDGCTAEGYYSDLSRTFVYGKPTDRMLKVFEVVHKAQAAAVATARPGIEAQVVDSAARKVITDAGFGPDYKNFLHRVGHGIGMDMHEWTYLVRGNSTVIKANMTFSDEPGIYLPGEFGVRLEDDMVITEDGAKLLTPQSNSLTDPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y9</accession>
    <name>E8X5Y9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4093</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70873">
        <property type="protein sequence ID" value="ADW70873"/>
        <property type="gene ID" value="AciX9_4093"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4093"/>
    <dbReference type="HOGENOM" id="CLU_016508_1_0_0"/>
    <dbReference type="OMA" id="DWFLHFQ"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230268" evidence="7">
        <location>
            <begin position="31"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="GH43_C2" evidence="8">
        <location>
            <begin position="354"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="553" mass="60728" checksum="946765C93192DF31" modified="2011-04-05" version="1">MDKMTPQPIRQALILLSLVLSSLIPAAAQAASPTGGVSAVWSADQGNGTYKNPVLFADYSDPDVIRVGDTFYLVASSFNQIPGLPILTSKDLVNWHFAAHALPVQPPDELYSKPQHGKGVWAPAIRFHDGKFFIFYPDPDLGIYMTQAKSIQGPWSAPLLIKAAPGWIDPCPLWDDDGNAYLVNALAGSRGGIKNIVVLSRMAPDGTALLDSGSIIVDGHLHDQTLEGPKIYKRHGYYYISAPAGGVVPGYHVVLRSKDIYGPYERRVVLAQGKTSINGPHQGAWVDTPTGEDWFLHFRDQGPYGRVLYLEPMHWANDWPVIGQNISKEGTGEPVATFRKPNVPSQPIATLPDSDEFNEPHLGPQWQWEANPQSDFAFPSKSMGALRLINEPQSSPNLWNLPNLLLQKFPAPDFTVTTKLTFTSRFAGEETGLVVLGQSYAYIAVRNTGDHLEVRQVERQDAEHDGKQTESQAVPVTSTTLYLRARVERDADKPEATVSYSFSTDGSAFQSIGTPFHATPGRWVGARIGLFATSPATTGELGYADFDWFRFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X637</accession>
    <name>E8X637_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar hook capping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4141</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70921">
        <property type="protein sequence ID" value="ADW70921"/>
        <property type="gene ID" value="AciX9_4141"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4141"/>
    <dbReference type="HOGENOM" id="CLU_1633085_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="15774" checksum="9FFF6AA1075325C8" modified="2011-04-05" version="1">MSSSFMAASPLSPANLLGQSAAAAQAKAKAKANAATTSSTTSDGLTGSTAGTTFLNLLVKELQNQDPTAPMDSTAMVGQMISLNQLDQLISINQTLGGSSSTATASVASAGQSSTSSAAVMAARASLLNSSAPSASDAATSAASDPGSTLDFSKLNIPNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X651</accession>
    <name>E8X651_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4155</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572847.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70935">
        <property type="protein sequence ID" value="ADW70935"/>
        <property type="gene ID" value="AciX9_4155"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4155"/>
    <dbReference type="HOGENOM" id="CLU_2395591_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10502" checksum="75E13B1E97086E98" modified="2011-04-05" version="1">MDLILGDAVILGVCLNLSESGLRGTFSHPVLAGAEGLLTIYQGEQNVQIHARVYSLKGDEARIRFRFDSEQEQQNIREFLKLVTPSSPKSWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X693</accession>
    <name>E8X693_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4198</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572889.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70977">
        <property type="protein sequence ID" value="ADW70977"/>
        <property type="gene ID" value="AciX9_4198"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4198"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="YIPGHYN"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230781" evidence="5">
        <location>
            <begin position="30"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="534"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1169" mass="124981" checksum="BAEE2EC252BA4876" modified="2011-04-05" version="1">MKFCQGLFRPRFVAAYLVLLAGSFVGAAAQDITGTISGTVTDASGAAIKGATVTLTNTDRGQDVRTLTTNGAGFYTGTSLPLGVYTVKVVDGGFKTESVTGLVLHVDDSLTVNRQLQVGSTDQSVTVQADALAVNLENSAVSGLINGTQVRELTLSTRNYEQLLSLQPGVAYTGATDQIYLGPTNPLGGANTVAFSVGGQRTSANNWTIDGADNVDRGSNLTLLAFPSVDAIAEFQTLRGVYSAQYGRSAAGQVNVVTRSGTNQFHGSAYEFFRNDVLQANNYFSNLSALKRPPLRYNDFGYTIGGPVFIPKIYDGHDKTFVFFSQEFRRVITYSPVTMYLPTANERTGLFPVAVCANVNSSGSCNNAGTTQLTTISPLAQAYLKDIYSTLPLPNPAAGQDMHQFTYNGRNVYNDTQEFFRIDQAFGQKFNVFYRFLHDSIPTQEPFGYGSGSVGFPGVQNSQTTSPATQHLGHVTYVATPTLLVDGGYAYSFGAIISRPVGTGTLAGSPDIKATLPYPVTLGVVPNLSFTSLTGINDAGNYNDYNRNHNIFANVTKVIGNHTIIVGGTFDRYQKTENATGGNNGTFSFTATTAQLPTATKALNNADQLYYQSFANFLSGTATGGFTQTALARTPNLHANTYEGYVQDNWKVTPRLTLNLGVRYSYFSQPTDSSGLLSNFLPSTYVAANAPTIDSTGSICTVAPCANAYGINGTVPNASYDPLNGLAFVNPAIGHASPYGNKVGQADTKNFGPRLGLAWDVFGTGKTSFRMGYGLAYDATLFGDYEINAFNNPPATAVANYTFTSFDNPAGAGATTAAAVTALPTIYSESEHYHTPYSQQYSLDIQQQMTPSLMLDVGYVGSHDTHLIGYIDINSLPVGAAKAAGLIPTGGIINSTQTKVLNQIRQYKGYGGMYGDDTIFTSNYNSLQVAVKKRFRGKSQINGAYTWQRLLTNSPADRSGAPQDRFNIRNEYGRSVLDRTDYASIDFIYELPFYKDQKGLVGRVVGGWEVSGIVALDSGLPITVAASAGNPINGVTFTDAGGLGIIGSSPAGFRPDQLFDPRNGTGLKTRQKWFNTAAFAAPSAALGQPGNARRGTIIGPGFNREDLGIFRNFRIFRESEFQLRGEAFNVLNHTNLGAPAVTATTATTFGTITSAREARILQIGGKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F6</accession>
    <name>E8X6F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4266</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71040">
        <property type="protein sequence ID" value="ADW71040"/>
        <property type="gene ID" value="AciX9_4266"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4266"/>
    <dbReference type="HOGENOM" id="CLU_2355774_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="10564" checksum="D78D01A515730EDB" modified="2011-04-05" version="1">MIVAADSNIYIFPKHPLFSGIDHHVLQNKYPAALSQVHISDAHPEAFGAINTEQSMSNIHFSRPFHVRSLMADCGGCDPESRCLPYAASLYGAYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P2</accession>
    <name>E8X6P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN-binding negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3916</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582210.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71192">
        <property type="protein sequence ID" value="ADW71192"/>
        <property type="gene ID" value="AciX9_3916"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3916"/>
    <dbReference type="HOGENOM" id="CLU_065853_0_1_0"/>
    <dbReference type="OMA" id="ARANPQW"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23432" checksum="512458690D641044" modified="2011-04-05" version="1">MYTPKTNAEEDLPTLRKFVRDNPLCALVTGGAKGMVASHIPMVLHEEAGGFGVLRGHVARANPQWKEFAAGEEALGIFTGPQHYISASWYPEKLTHGREVPTWNYVAVHAYGPLRAVEDPAWLLEHLRTLTDENEVIAAVPWKVADAPTEFIAKLCGGIVGLEMQVVRVEGKWKVSQNRNERDAAGVMEGLDGLGTAEAKVMRELVEARRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V9</accession>
    <name>E8X6V9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3985</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71259">
        <property type="protein sequence ID" value="ADW71259"/>
        <property type="gene ID" value="AciX9_3985"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3985"/>
    <dbReference type="HOGENOM" id="CLU_492407_0_0_0"/>
    <dbReference type="OMA" id="AIKCYDE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234462" evidence="2">
        <location>
            <begin position="30"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="553" mass="60222" checksum="4CC03524E1FCBF78" modified="2011-04-05" version="1">MTRAKSHLRKAAMLAVLPVLACGFGSAMAQGVSGAQRGTRSAEAEQLHEAIMTAQRGDGAKALALTRALLASHPGYEPALKFQGALLEDMGHAPEAAASFQEALKLAPGDAELMLKVGINRLVAGDTGEAIRLFTQRLKQVPQDGDTLYYLAQAYHLRGDSELALKAIQRSLKADPNNTAVWQKYGELLCSSGDNEAALRWLLKAQHADPTLGRIDFDLGVASFKNQDLENAAQYAAKAVALKPNDLKGLQLLAAVDVKLSKWQEAKPVFEQILSIQPADDAALLGLGHCELALKNYQAAADLLERLLKQDPTQVLAHFYLARVYAGLGRTADAQHEAELHGRLLDQAASVVPTDEREVEKATLVEARQLLTEGHEAAALKLFRDRAKGPTATPGAPYMLTGVVYLYMGRPEDAERCLKQSMVIEPTVRGAHTYLGMLALQQNDLEKAESEFKAELQGEPNYQLAVAELGEVRYRQGRWEEAADQLARSKTVVPALLYMLCDSYFHLGKVKDADLTAELAVGYGKSDPAITKGILDLLERNQQTELVQRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X737</accession>
    <name>E8X737_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4314</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572990.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71271">
        <property type="protein sequence ID" value="ADW71271"/>
        <property type="gene ID" value="AciX9_4314"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4314"/>
    <dbReference type="HOGENOM" id="CLU_013093_1_2_0"/>
    <dbReference type="OMA" id="NWARFMC"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Melibiase_C" evidence="6">
        <location>
            <begin position="408"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="488" mass="53332" checksum="52CAA169128271C6" modified="2011-04-05" version="1">MILTLLVMPVFGQSADGKWIGVQRVLDNGESDRIFLDLHQKGSDLTGTVTTLGHIYQVKGTMANGHFALFSSPQDSKPKLTGEVDGQTLHLTRDSDSFAAQPARPGDEYPPFEHIELPALHNVPPNGMAKTPPMGWNSWNLFESRIDDKTVREIADAMVTSGMRDAGYVYVNIDDTWEGVRDAQGNLGSNKKFPDMKALADYVHSKGLKFGIYSSPGPRTCAEYPGSYGYEDQDARTFAAWGVDYLKYDWCGARMTFSVEDLQAVYQKMGDALLKSGRPIVYSLCEYGNGHVETWGTKVGANLWRTTGDIHEPWTSMIGNITKQIPTAPFAGPGHWNDPDMLEIGNHHMSDDEDRTQMSLWALTAAPLLAGNDIRLMPASTRAILMNAEVIAVDQDALGQQAVPIKSGGLDMWVKPLADGSVAVGMVNMGATEATAEIKANELGLGTQVKSARDLWNHTSVAFHNGAYLAKVPSHGVLMLRVSGERQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D2</accession>
    <name>E8X7D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4416</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573085.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71366">
        <property type="protein sequence ID" value="ADW71366"/>
        <property type="gene ID" value="AciX9_4416"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4416"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_0"/>
    <dbReference type="OMA" id="EIVAWAA"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="18511" checksum="03110735D6899776" modified="2011-04-05" version="1">MSEATVSMFHPKKILVPIDFSPSSIAALATASQMAQQFHAKLCLLHVIPMLPIVSGLEFPTAFYPRQEFLADAEEDSAKRFVDLVDHLAGQGVEATFKVEIGNDVVGNVLMVLEREHADLLVISTQGMSGWRPVVFGSIAEKVVKLAECPVLLLRTAKTTVELKPRVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F6</accession>
    <name>E8X7F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV secretion/conjugal transfer ATPase, VirB4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4444</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbE/VirB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573109.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71390">
        <property type="protein sequence ID" value="ADW71390"/>
        <property type="gene ID" value="AciX9_4444"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4444"/>
    <dbReference type="HOGENOM" id="CLU_355547_0_0_0"/>
    <dbReference type="OMA" id="PTSTIWT"/>
    <dbReference type="OrthoDB" id="182908at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018145">
        <property type="entry name" value="CagE_TrbE_VirB_cntrl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03135">
        <property type="entry name" value="CagE_TrbE_VirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CagE_TrbE_VirB" evidence="2">
        <location>
            <begin position="297"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="789" mass="88587" checksum="5E8CF6F759879BFD" modified="2011-04-05" version="1">MTLAKTNQHKQTPWFAQAGAACSIVPISRFVSERDFALKGEGYGCLFSLTGKDEESLTDQEIEATVRDIEGATRGLPEGFCLHQYVRVRSGLDIPRQDGYESPITEGFVADRVGFLNRTAKFRRIDLHWCLTVEPATSNPLSRKPSDHAEDTSQMLASLQKAAITLESHLSSSLGLKIVRKEEAFRFFSYLFNLEEWAGLDHLRADTGVDRQIVKSPVSWHKDHLRVGKRYVQLFSLQTSPEASRPCLFADLMKLDCDTILCSTWRPRSHTAVRKEIDQQEKFISFFKVGVLSRVMSGRDSASLDSTAGAKAASLSVDDLSGVIRELDKKSQGIYSLSLLCAADSAEQLQAVTPSVHRIFVEARAQVVAETLGNLSAFYAMFPGNRKFQVFETWLGENHHARLSNAFAPHTGHPYSEDLDAEYLNIFETRSGTPYYQDVYVNGVRVMLILGPTGTGKSVHGNQAVSHEQKYNGFTFIFDIGGSYESVVELYGGKVDRVGKDGPRVNPFALEPTESNLKFLYSFMKLLLVNGGAELTPEDDDVIFNAVQDMYLLDPENRRLSSLFLPKHLQRYLSKWVGKGIYSAVFDNVKDELSLSRLQCFDFQGVNNAQYADLVEPLMVWLLRRIDDVLYDPANLGVPKHVLIEELFSSMKNKQLLDAALSSIKTVRKNLGGVTLIGQSANDLGDNADSIVNSCTSFLFLRDATFNRPHYKQLFKMTDHQLDLFESLREREGLYIRRDGQTKVVTLNLDPHSYAKFSTKPKDKVRRSKLVAKYGLHEGIDRFVQGELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H4</accession>
    <name>E8X7H4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4462</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71408">
        <property type="protein sequence ID" value="ADW71408"/>
        <property type="gene ID" value="AciX9_4462"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4462"/>
    <dbReference type="HOGENOM" id="CLU_2094442_0_0_0"/>
    <dbReference type="OMA" id="IMHHRIS"/>
    <dbReference type="OrthoDB" id="1931027at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12591" checksum="A58384EABA9184D1" modified="2011-04-05" version="1">MWCWRCKSEMPMLSEDEFSSVQALYSGGIKATKEFRQKWGIALEGVPIDDLFRPVRTRYEELTSMKDCHQNAIMHHRISLYGPPCEQCGKPLRTPKAKLCGACMHPKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L2</accession>
    <name>E8X7L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4502</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573165.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4502"/>
    <dbReference type="EnsemblBacteria" id="ADW71446">
        <property type="protein sequence ID" value="ADW71446"/>
        <property type="gene ID" value="AciX9_4502"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4502"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050833_0_3_0"/>
    <dbReference type="OMA" id="TVFLHFC"/>
    <dbReference type="OrthoDB" id="842233at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="35778" checksum="16EB80A569590B51" modified="2011-04-05" version="1">MTTDREQQDLIPVLFCTDHHYWKHLGVAIASLLAANPSLRFRIIVCSMIENLAAEPKIREIFPAVEFVRYNINQYGFRTDRNITIASYLRLFMTEFVDLAIDKLLYLDCDMVVCGNIQSLWETDLSVSSLAAVPEPYAGQAALGFKAGDPYFNGGTLLINLKLWRAENLLEQFLRYANLHAEHLLAHDQDILNGVLRGRIIALSYRWNFHAPYADCSPGQLRIGAREFAQIRKLPAIVHFVGSAKPWSFDEEPHYKDLYWRARALTPWQTPAPKTKFRTQLRERMNWYFPRFSAVLRSLAGKRSRLDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M3</accession>
    <name>E8X7M3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573176.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71457">
        <property type="protein sequence ID" value="ADW71457"/>
        <property type="gene ID" value="AciX9_4516"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4516"/>
    <dbReference type="eggNOG" id="ENOG5032X9E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249166_0_0_0"/>
    <dbReference type="OrthoDB" id="1302146at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="25140" checksum="BAC849B48860DBA7" modified="2011-04-05" version="1">MIEDISLPVTPTATTSAISTPTPTVLPSMASATPQESSSLSWRSFNYGGKTHTFPQLEPDTFVFVRPDSKEAPSEKFTVDIRYTDHCFTRSPRPGEEYDLSQVWSMRTLGNGVKKVRLFCPMRNELSKLLPDLIRSFPDKKPHHNKEKRNFFTVDTLTYQGNPVKYDIIFSVRKSGKGRLELLVETAYVDEPDYPAAPLDGRRVRFWIILNNTLKGIKIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T1</accession>
    <name>E8X7T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4585</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71515">
        <property type="protein sequence ID" value="ADW71515"/>
        <property type="gene ID" value="AciX9_4585"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4585"/>
    <dbReference type="HOGENOM" id="CLU_1537947_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19069" checksum="5C1803F4411E79B3" modified="2011-04-05" version="1">MVQSFHHGLAMPALLDHGQWPPSAPLQVKHINSYPLSAVLAWIFPLSQLTMADRCRHGSVSTPISQINCGKSIPTETIRARLCKQRKYLYIRAAGRSFVTGLWSASFRFSAKPAYTDVKNLISMLGDPGGSFSPGKLDYTITGADASQSHALAERDGSFSLFVWLEHSSYNAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U0</accession>
    <name>E8X7U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4594</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573243.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71524">
        <property type="protein sequence ID" value="ADW71524"/>
        <property type="gene ID" value="AciX9_4594"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4594"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_0"/>
    <dbReference type="OMA" id="REDRKGP"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="327" mass="36435" checksum="6C68677BA1186BF1" modified="2011-04-05" version="1">MRTPTSTLQKPSGAQSGVLIPLLSIFTARPEARTRMRDFFSSHIRNPSSRRAHREAVRQVSDFCAEHGIGDLAQVEPVHVAAFVETQLKTQSKPTAKLRLAALRMLFDWMVVGQVIPTNPAHSVRGPKHSQRRGKTPVLQADEARTLIDAIDTTSLPGLRDRALIGLMVYTFSCVGAAISMRVEDFFVQGRRGWVRLHEKGGKEHEMPTHHNLDRYLEEYIDAAGIAEDRKGPMFRTTSGRSGELTGNSLLQSDVWRMIRRRALAAGIKTEIGCHTFRATGITAYLKNGGRLEIAQQMAAHESARTTGLYDRRSDEVSLDEVERIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X803</accession>
    <name>E8X803_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4657</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71587">
        <property type="protein sequence ID" value="ADW71587"/>
        <property type="gene ID" value="AciX9_4657"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4657"/>
    <dbReference type="HOGENOM" id="CLU_914536_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="35414" checksum="B33E3D7CAE73AA5E" modified="2011-04-05" version="1">MTTAQQRLRCRPEQARKRRLRLGSAESRSHFTAPRRRFRVPTKVCTGQLRRPNSSQRRAQNLLPKMVFHDRAVYQVEHAAQLIMARRLDPPPKGRIHLRRPVDVALRFSLAVVRRTIHLRESCKNRVMKKLVLIVVMAISFFLLFPVSWRIGQRFFTRPFNKKFYDPILLVCRDHVEFRLWHELGGSEPASALGEGCTLQVTPERQRWVEEVVPQMKSPGDSSWTVRVKQLGENRQWIDLELLGDGIAGMIYEVRGNEITPLNSRLTGPEGQLYVLVVNLLLWVAIWIVVWGIRPWVVRVSIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X810</accession>
    <name>E8X810_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4664</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71594">
        <property type="protein sequence ID" value="ADW71594"/>
        <property type="gene ID" value="AciX9_4664"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4664"/>
    <dbReference type="HOGENOM" id="CLU_137873_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="18240" checksum="BFDA761427DD8694" modified="2011-04-05" version="1">MMVSLLQIVGCKQAAIHPTFMVSSVDRQITGTSVFPVAVDPNLVGTYPVEPASGGGYFYDDVLEYRVWLNPNNGAEPLNGRNDYFVAFAQYEAAAAFSRKASGASPPFALVRQLEWIEEPNHGEFVPQKTERITEWQLDWLKTQKRTAKSIDQFMKHPFEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X814</accession>
    <name>E8X814_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71598">
        <property type="protein sequence ID" value="ADW71598"/>
        <property type="gene ID" value="AciX9_4668"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4668"/>
    <dbReference type="HOGENOM" id="CLU_1854254_0_0_0"/>
    <dbReference type="OMA" id="IVHHRIP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="14401" checksum="6287859BF9377BC4" modified="2011-04-05" version="1">MGLCSTCYTLKRQDEEYFGGLREAVLERDGYRCRVCDASGRDKWSIIVHHRIPGRSVLKLMLSLCPGCHAKVHRTKAVLSAMPPLLLELWREQHPKGHEQKQLDFSSRKPAAKLIPLFRDEKESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA6</accession>
    <name>E8WVA6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0207</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578609.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0207"/>
    <dbReference type="EnsemblBacteria" id="ADW67281">
        <property type="protein sequence ID" value="ADW67281"/>
        <property type="gene ID" value="AciX9_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0207"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="EMQWRER"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="6">
        <location>
            <begin position="335"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1076" mass="115038" checksum="12E678609B0B74CA" modified="2011-04-05" version="1">MSKFFINRPIVAIVIAILTVILGTVSMFTLATSQFPDIVPTEILVTATYPGADAKTLAQAVSTPIEQQMNGVDNMIYMDSVSANNGVVQLFVDFDVKTDPNIDQVLSQLRVDQAQSQLPAQVTTAGLTVQKALTSPLMLIAVNSPGNKLSQDFLTNYAIINLQDQITRVKGVSRVQIFGGQYALRIWVDPNKLAKLGVTAPEVIQAIQTQNNVNPAGQIGAEPIPKGQQFTYTVRTQGRLVKPEEFGAIILRANADGSILHLSDVARIELGDQAYAISGRYNQNPSGVMAVYQLPGSNAVETAKLVNARMKELSATFPTGISYNVPLDTTKAVSSGINEIVITLLEALGLVVVVVFIFLQGWRATLIPLLAVPVSLIGTFIIFPALGFSINTLSLFGLVLAIGLVVDDAIIVVEAVEHHIDEGMDPKSATIKAMEEVGGPVVAIALILAAVFIPTAFIPGITGRLYQQFAVTIAISVLISAFNALTLSPALASLLLKPKNKEQKPGLLGKGFALFNKFFGRTTESFVHTSDVLIHKSYLAMLGIAIIAVLAVFLGSSLPGGFLPTEDQGYMFLALQLPDGASAQRTDAAQQKITAALLKTPGVEGVIAVTNFSLLTQVQSTNQGFFFVALKPWEVRKSKEEQLTYITASLGKQLAGNPDGIAFAFPPPSIPGIGTSGGVTMVIEDRSGKDDPTILTKNLMTFLGAISKLPEVAFALPSYSPAVPQLYADVDQEKVLQQQVQLSDVYTTMSTFMGGYLVNYFNRFGRQWQTYVEAEGTSRTDIKNIDQFYVRSANGGQVPLGSLVHVKQITGPEYIFRFNEFNAAQVNITAKPGYSSGQVRAALEKTFHDTMPPGAGFDYSGISYQEDMAQKGVPTYAVFGLSLLFVFLILAALYESWTLPFSVLLSTPVAILGGYIALHIRTLENDIFATIGVVMLIGLSAKNAILIVEFAKTNYESGMSISEAALSAARLRFRPIVMTALAFVFGCLPLWTATGAGAASRRILGTTVIGGMFLSTAIGLIFIPVTFSVVEYVSHRFSKGGKGTTMDSKADFDPVAAGKAAGGGPQHSTPTPGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB8</accession>
    <name>E8WVB8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase with PAS/PAC and GAF sensors</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0219</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578621.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0219"/>
    <dbReference type="EnsemblBacteria" id="ADW67293">
        <property type="protein sequence ID" value="ADW67293"/>
        <property type="gene ID" value="AciX9_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0219"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_32_0"/>
    <dbReference type="OMA" id="DPLTQLW"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="352"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="496" mass="56150" checksum="BF66633AE8B70B38" modified="2011-04-05" version="1">MAGEMEQAVDAGALEQRRLAALRECNLLDTERELEYDQLIALAAGVCATPMGFFTLVDEDRQWFKASMGLEVSETSREVSFCSHAIKQTNLFVVEDATEDIRFKENPLVLGGPTIRFYAGMPVAGPGGELIGTVCVADVVPRKLTAEQRSALEILAMQVRTRMEMRIQQKKLQEALSAREELLSELRSSELRFRTFMDNAPFLGYMKDFQGRFLYYNEVMAERFRVSKDQWLGKSVIDLWPGELGESIVRNDREVLEGGRLIERFEETIDEFGQVFSWKSSKFPCLNEKGQMLLGGFSVDVTEDVARQKALEDANLKLEQLATRDGLTGLLNRRALDEKIELEFENVRRHKEPLSIVLLDVDNFKRRNDQFGHASGDQVLRQLGHLVSNTMRVLDTAGRYGGEEIVILLPKTDYEGALLFAKRLHDGIHRERWAIEPVTASLGVATTSATTKDSNRLLAQADDAMYEAKRSGKDRIVAHRDVLERKMAELLYERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC1</accession>
    <name>E8WVC1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0222"/>
    <dbReference type="EnsemblBacteria" id="ADW67296">
        <property type="protein sequence ID" value="ADW67296"/>
        <property type="gene ID" value="AciX9_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0222"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001649_0_0_0"/>
    <dbReference type="OMA" id="DDATHFQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1404" mass="141077" checksum="CF6A123DDCE4F6E5" modified="2011-04-05" version="1">MPVGPAQVLSSAYGLVTGRITSIALDPSDTSGNTLYVGTTGGGVWKSTNASGPAASVTFTPLTDTLPVFRANAGTGATASLSIGALAMANGVLLAGTGDPNDSSDSYFGSGLLRSTDGGLTWTLIQSSQDGVAGIHRFFGLSFAGLAFSTATPTLAVAAVSQATEGTLVNAPYATSSVMGLYFSTDAGQTWQMASVYDGSQVVQSAQKPSNNAATSVVWNPIRQRFYAAIRFHGYYESKDGQTWTRLIHQPAASLTQAACPTNTATSSCPIFRGVLAAQPTTGDLFALAVDSTNNDQGLYQDACNLTGSACASNTVLFANQLTSTPLETGNGITAIQQADYNLALAAVPSGTDTLLYAGTIDLYRCSLASGCQLRNTTNAANGCTNPAGVAPAQHAIAVLDALVFLGNDGGLYRSTDAVNEQAAPCSIDDASHFQNLNAGLGSLSEVVSFAQDPADPNTLLAGLGALGTAGTSYSPNTWPQLAPGEGGAVAIDPATPSLWYLSTAAGVSIARCSKGSACTAADFAGTPTISEAQVSNDPSAIDAPWLLDPSLPSNLVIGTCRIWRGPASSGSLWSSSNLLSRPFAAAAATACPSNLPVVRSLAAGGAVSAGTSAQNAGSEVLYAGLTGDPSSSGTSFGGHLFVTAAANLDSSSTVWTDAAASSVVNDPSGSGIFNPGQFDVSSIAVDPHDTTGHTVYATIMGFAGNNLSVTHLYQSTDAGSHWFNISSNLPNAPANSVVVDPNDANTIYVALDTGVYVTTQVTTCTSANCWSVYGTVLPNAPVIQLQAAVSMPTGDGRIGELRAATYGRGIWQVPLLTAISPAAPGLAVNPTSLVFASQQVGSTSAAQTVTVTNTGNAPLTISSIVPTGDFLETDNCTSTPIAQQATCSIQVTFLPTAAGARTGLLTVYGNAPGGQATVTLSGTATPAAAIVLTPTVLTFPSTTVAASSPVQNITISNTGGTIASLQSPVITGDFVISANTCTKSLGPQTGCTVSVTFTPTAPGTRTGALTVTDDAGTQTASLTGVGTSPATDTLTPLSLIFSPQQLNSSSLAQGLTLLNSGDVPLTLIAAQITSGDFSVVNSCGNSLNPHSSCSLTVVFTPKSLGQRSGTLVLSDQFRSQTVTLSGSGLAPPGVSLAPITPLVFAPTPVAAASASQTVTLTNNGGVPLSLASINVTGDFTIPANSNTCTATVAPSAVCAFQVAFAPTAPGPRTGLLTVTSNAPNSPQTLALSGSGVDFTLIAGSPSAQTIISGQTATYPLLLSSVAGVPGSVLFTCAGVPAHATCTVNPPNPALGSTSTITATVATGLFAAVAPPVFPWTANPVWLAVLIPCGMFLRKRRRVILLSLLLVTIAGCATGRTVPSAVTTNPTTPATPTPSGTYTLVVSASSAGLVRTANLTLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE0</accession>
    <name>E8WVE0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="6" type="ordered locus">AciX9_1326</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579711.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1326"/>
    <dbReference type="EnsemblBacteria" id="ADW68388">
        <property type="protein sequence ID" value="ADW68388"/>
        <property type="gene ID" value="AciX9_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1326"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_1_0_0"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="10818" checksum="0039C6BADD622BE8" modified="2011-04-05" version="1">MATTSFTPLHDRILVRRTEEGETMRGGIIIPDSAKEKPQQGEVVSVGKGKSNDEGKVFPLDVKAGDTILFGKYSGTEIKLDGEELLIMREEEVLGIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI5</accession>
    <name>E8WVI5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1374</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579755.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1374"/>
    <dbReference type="EnsemblBacteria" id="ADW68433">
        <property type="protein sequence ID" value="ADW68433"/>
        <property type="gene ID" value="AciX9_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1374"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_4_0_0"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="34471" checksum="224F1D1EB50F52BD" modified="2011-04-05" version="1">MLAPNKKIGLIQMSCVPDTQANLDKAIHMTREAAHAGANIVCLPELFRAQYFCQREEHALFDTAESIPGPSTEALAEVAKQEGIVLIASLFERRAAGLYHNTVAVLETNGEIADTYRKMHIPDDPLYYEKFYFTPGDLGFKAQQSSQGPIGTLICWDQWYPEGARITALKGAETLFYPTAIGWHPSEKAEFGEAQYSAWQTMQRSHAIANGVFVGAVNRVGHEYGDVIHNGVTMPGPGPHTLDTGLEFWGGSFIADPFGRVIAQASHDKEEILIAEIDRKLLEDTRRNWPFLRDRRIDAYQGITSRYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL9</accession>
    <name>E8WVL9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2516</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580863.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2516"/>
    <dbReference type="EnsemblBacteria" id="ADW69548">
        <property type="protein sequence ID" value="ADW69548"/>
        <property type="gene ID" value="AciX9_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2516"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_0"/>
    <dbReference type="OMA" id="RDGITMR"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="35645" checksum="12BACAB70E2CF059" modified="2011-04-05" version="1">MQRPTLELRHFNAIVTLAEELSYTKAARRLGMSQSGLSRSIQDAERRLNRKIFDRNRSRVELTDAGRACVAEARLSIEHEERAIQFTKAVAHGVDSTLVVGRSQYTDPVLSEVLLSLHLPLHPNLDVQLHSEFAPELEHGVLCSRLDLALITHPDANPRLTTVQLTEAPLHIVLSEDHPIAKKHKVKLKDLGGSRWTVFDRRIHPSLYDTLIGLARFEGIEYRALNHVMSADEAAHLLLKSGGIAFLTRAGAHRIARQGLVAKPLDEEALKLDVHLAARADNASKLVSEFVRTFVKKLKTVLLPPQLTLLIEPGDGHLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ0</accession>
    <name>E8WVQ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2549</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580894.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69579">
        <property type="protein sequence ID" value="ADW69579"/>
        <property type="gene ID" value="AciX9_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2549"/>
    <dbReference type="HOGENOM" id="CLU_1223310_0_0_0"/>
    <dbReference type="OrthoDB" id="2137878at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24330" checksum="5579FCCF346AF934" modified="2011-04-05" version="1">MYSQRMIHDWARRLVASEVDTESPSARTEGATLRVYEKLRQKLRAPVGVDGFQALAARALSLAKSQSPRLSTVQVMATGDLSGLSEVELQAGTDEEDVVGIILIAQLLGLFLTLLGEAATVSLIESEPVRIDTKSEMEIPEATIPAAGTSYLGPFEDILLEADQLRNVSERLETLADKHVGIEEVMSVAGSIRNIAAVLDVFTVIRSKPGGLKANVLTSPQNGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW1</accession>
    <name>E8WVW1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582029.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3719"/>
    <dbReference type="EnsemblBacteria" id="ADW70720">
        <property type="protein sequence ID" value="ADW70720"/>
        <property type="gene ID" value="AciX9_3719"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3719"/>
    <dbReference type="eggNOG" id="ENOG50349E0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406226_0_0_0"/>
    <dbReference type="OMA" id="TEAYAFR"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233415" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="20434" checksum="8961E2C0A4486627" modified="2011-04-05" version="1">MKIFLALALACSASLQAQSIPEEAPIAPAVTAFEAALVGRWSGVLEYRDYQTNGRTKLPTWSSISLSHTGLTWQYTYDDGPNKQVVENLAVTVTPASYKVVNTDKPADATTSSVAGLDALKNGRGTLVLTGTIQENNHPVEARTTLTLRRNLLEIVKETRAAGEEFKFRDGYTLTRLTPLYEAPPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW47</accession>
    <name>E8WW47_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0281</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578681.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0281"/>
    <dbReference type="EnsemblBacteria" id="ADW67353">
        <property type="protein sequence ID" value="ADW67353"/>
        <property type="gene ID" value="AciX9_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0281"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_0_0"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="32335" checksum="D51810B249386F27" modified="2011-04-05" version="1">MILLTGSTGQVGSALVQALAPFGRVVAPTRAELDLVHPASVREFVRKVNPRWIVNPAAYTAVDKAESETAQAYAVNAELPRILGEEAAQSGAAVIHFSTDYIFDGEGTLPYTEKDIPAPHSIYGSTKLEGERALAATGAAHLIFRTSWVYGATGKNFLLTILNAAKARPELRIVADQHGAPTWSRDLARLTNHAIARAETLANGRPLPEALQPLSGVYHACAAGETTWFGFAQAAVEHEQQRDPAQKLATLTPITTAEYPTPARRPANSRMDTSKLGSLLGFHFPQWQDSLNSVLAELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ6</accession>
    <name>E8WWQ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0312</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578712.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67384">
        <property type="protein sequence ID" value="ADW67384"/>
        <property type="gene ID" value="AciX9_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0312"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_0"/>
    <dbReference type="OMA" id="IVIWRQG"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="192"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="554" mass="62578" checksum="5288D4F182F21D00" modified="2011-04-05" version="1">MLASLNDPFQQISPSAHDIPTMHFEPLGKEVKALMVWPRFPPSFWGFEGVLEMVPEKSVMPPLGLITVAALCPSSWVIRLLDLSFEELREEDLLWADLVMVSSMQAQRIDTLDVLSRARRLGRRTFIGGPWASSEPEFLTTQADHVFVGEAEEVFGDIAHQLEQGSAQAIYKVADKPDMSVSPIPRFDLLHMNKYTSMSVQFSRGCPFQCEFCDIITIYGRRPRAKPPEKLIAELDALLALGWRNEVFIVDDNFIGNHKLALQLTHSLAAWQDRSKRVISFYTEASIDLADKPELLASMVEANFMYVFLGIETPSAEALKGSSKFQNLRGDLVTQVSKIRESGLWVLAGFIVGFDSDDETIFERQLQFIDKTAITWAMAGVLQAPPTTALFDRMKREGRLIEDSTATTNFSAPNFKTVLPLPVLLRGLSTLLTGLYTPANYFGRAMRSLESWKPRPAQRPPELPLLYNLRVFVQSIWQQGVCSNYRLAYWRFLLTAIRRWALQPAKMWLAFMVLLSANHFLKYARAVAEDLEAQCQVLEDLELSSQTLAVVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY6</accession>
    <name>E8WWY6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579867.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1494"/>
    <dbReference type="EnsemblBacteria" id="ADW68547">
        <property type="protein sequence ID" value="ADW68547"/>
        <property type="gene ID" value="AciX9_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1494"/>
    <dbReference type="eggNOG" id="ENOG50332HE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2093395_0_0_0"/>
    <dbReference type="OMA" id="SFHYRFK"/>
    <dbReference type="OrthoDB" id="1912892at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233935" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="116" mass="12367" checksum="1A4F247C3483ACD1" modified="2011-04-05" version="1">MRLLRLIGCGLGLGLVGCHSAYVDATLVNGTDKPLSLVELDYPSASFGTQTLAPGGTFHYRFKVLGSGALKLIYTDTKEKEIDVKGPELHEGDEGSLTVTVGAAGTSWDEKLKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY8</accession>
    <name>E8WWY8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1496</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1496"/>
    <dbReference type="EnsemblBacteria" id="ADW68549">
        <property type="protein sequence ID" value="ADW68549"/>
        <property type="gene ID" value="AciX9_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1496"/>
    <dbReference type="eggNOG" id="ENOG5032RGJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142809_0_0_0"/>
    <dbReference type="OMA" id="VRDFNTA"/>
    <dbReference type="OrthoDB" id="1551081at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="19875" checksum="0D6E633023401EAA" modified="2011-04-05" version="1">MASSRKKVLVRMLDQTIHAGYLPLMGIVSGMETGLPVIELLDLSGRLETLALDEVRHVAYVRDFNLDNAVDPENLVRRTFLARPRTEGLWVRIQFAGGDVLEGLAALDIGLADGLLEDRGVYLIPPDIRSNTQRLFVPRAAMTQLQVLGVVTTPSKPARVVKVAAESIQDDLFPALSSDSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX32</accession>
    <name>E8WX32_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1540</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1540"/>
    <dbReference type="EnsemblBacteria" id="ADW68593">
        <property type="protein sequence ID" value="ADW68593"/>
        <property type="gene ID" value="AciX9_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1540"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_1_0_0"/>
    <dbReference type="OMA" id="CRGWMHS"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="65"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="584" mass="63231" checksum="2054CAE820D1B798" modified="2011-04-05" version="1">MAQAQADTSPNTIYVHANILTGAHLRGNDPSGVPARATALAVTNASVVAVGGDEELLRLKGPHTQVVDLDGAFVMPGFNDAHTHMASGGQQRLSVDLDATPSLADMLERIKAYTASAKPGQWIQGAGWDHTLWANKTLPSRQDLDTVTGGHPAVFYRTDGHIVVANSAALLAAGISSATTAPQGSKIDRDKDGVPTGIVRESPAIAMIMAKVPPPDPDVRRKALEVAIADALAHGVTSVQDFSDWDDWLVLESMEHTGKLNLRVSEWMDFNLPLSTLKRRRATHDANDPLLHLGQLKAFMDGSLGSRTAALREGYADDPNNSGLSRYEQDKVNNMAAERAAAGFQLGFHAIGDEANDVALNAFEAAEQVGVPADAKAQMAHPDSDVSEGAPAEYTGKDMRFRVEHAQVVLPEDFERFHTLGVVASMQPSHLLTDMKWAGDRLGPERSKDAYAWRSMLDHHVPLAFGTDYPVESISPFRGLYSAVTRANEGRTMTFHTEQRLTIQEAIYAYTQGSAYAEFRETRKGRLEAGYLADFVVLDHDLTKATPDEILRTKVLRTVVGGRMVFQAGNQVMPSGRKAALDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH7</accession>
    <name>E8WXH7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">AciX9_0438</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578838.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0438"/>
    <dbReference type="EnsemblBacteria" id="ADW67510">
        <property type="protein sequence ID" value="ADW67510"/>
        <property type="gene ID" value="AciX9_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0438"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_2_0_0"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="28383" checksum="4C663F1B4002243F" modified="2011-04-05" version="1">MPRRVEVSVRVSSGAGEVAKATADLFAKAAADAVKTRGVARIAISGGSTPKAVFALLASEPYVGQIPWAQIQLFWVDERCVGPDDPDSNYGMTKKAMLDSVPLPAANVHRMEGEMDPAEAASRYEAEIRNTFKLEGAQTPTFDLILLGMGDDGHTASLFPHTEGLDELARIVIANHVPQKDTWRMTLTWPVITQGREVAFLIEGAAKAEILHTVMQGKYDPETYPSQLIRPASGRLTLMLDTASAAKLELPPVVNGVTTMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW6</accession>
    <name>E8WXW6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="11" type="ordered locus">AciX9_2788</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581126.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2788"/>
    <dbReference type="EnsemblBacteria" id="ADW69811">
        <property type="protein sequence ID" value="ADW69811"/>
        <property type="gene ID" value="AciX9_2788"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2788"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_0"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="10">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26326" checksum="FDCBE229CCCA61C5" modified="2011-04-05" version="1">MTTPPPNPTPRQQPVIAIDGPAGAGKSTLAAHLARRFGFLNLETGAMYRALAYKAIDSDLDLDDEVQLLALTPHTTIALEPTREGNRVLLDGRDVSRRIRDADVTAAASRLSVHPRVRVWMVAQQRALGIQGGVVMEGRDIGTAVFPDAEVKIFLDADPNVRGTRRFRQVAPDQHEVAPVTEAAVLAEMRARDDRDRNRAESPLKPAPDAILLDSTSMSLDEVLARSEEIVRAHLPPTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW9</accession>
    <name>E8WXW9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2791</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2791"/>
    <dbReference type="EnsemblBacteria" id="ADW69814">
        <property type="protein sequence ID" value="ADW69814"/>
        <property type="gene ID" value="AciX9_2791"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2791"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459363_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="18658" checksum="BBA1BD05C73A3DF0" modified="2011-04-05" version="1">MSEYLATSYRPDCEYVDGELRGRNVGEWLHARSLALMASWIGGHENEWNVIGCISLRVKTSSSRVRVPDLVVLRPRVQPDILTEPPLLVIEILSPGDSYWDLQERSRDYQAMGVETVWIVDPKTRSGRVCRGEEWIGAERLEVAGTPIYVELKELFARLDQSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY4</accession>
    <name>E8WXY4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0451</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578851.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0451"/>
    <dbReference type="EnsemblBacteria" id="ADW67523">
        <property type="protein sequence ID" value="ADW67523"/>
        <property type="gene ID" value="AciX9_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0451"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_4_0"/>
    <dbReference type="OMA" id="LEMSHVE"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233971" evidence="2">
        <location>
            <begin position="27"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="3">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="4">
        <location>
            <begin position="229"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="578" mass="61522" checksum="4B75CAADF9285CD5" modified="2011-04-05" version="1">MNSARRDLLKLSPLALAALAPATSFAAPRTPTNSPLFFDIRTFGATGSGKSLDTPAVNAAIEAAAAAGGGTVVFPAGTWLCFSIRLKSNVALFLSQGAILLAAESPKPGETTGQLGGTYDPAEPQGDFEPFQDYGHNHWHNSLIWGENIHNVSISGPGLIYGKGLSYGAGPGRPPGTMPRPGFGPESGLGPDGKPRGQLSAQPVNQAPRPPRGDYPMYQAEQPGVGNKAIALKNCRNVQFRDFSLLKGGHFGLLLTGVDNLVIDNLTIDTDRDGMDIDCCKNVVVSNCSVNAPWDDAICPKSSFALGFNKPTENMTITNCIVTGWYQLGSVLDGTFKKIPADAPRVTRNGRIKCGTESNGGFRNITISNCVFEGCYGLALESDDGALCEDIAITNITMRDCVSGSLFFRLGNRLRGPKDSTKVGTMRRILVSNVTSYNTLPKFCNILSGIPGYPIEDVKIANVYAHSLGGGTSEDAALVPPEAADKYPDPGMFGPMPTQGFFLRHMKNLEMSHIEIASATPDARPSFYLDDVTRADFLAITAPTATPAFALHNVTDLRIHLSRAAKDTILPTANNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY19</accession>
    <name>E8WY19_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0486</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578886.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0486"/>
    <dbReference type="EnsemblBacteria" id="ADW67558">
        <property type="protein sequence ID" value="ADW67558"/>
        <property type="gene ID" value="AciX9_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0486"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_20_2_0"/>
    <dbReference type="OMA" id="DWDSLNH"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="9165" checksum="1CB1D77B7AE4798A" modified="2011-04-05" version="1">MSNEELLAGLQEIFQDVLDLPDLVLTPESNAQNVPDWDSLAHVNLITMIEKKYKVKFALGELQELKNVGDMITLLQAKLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB1</accession>
    <name>E8WYB1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580057.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1689"/>
    <dbReference type="EnsemblBacteria" id="ADW68738">
        <property type="protein sequence ID" value="ADW68738"/>
        <property type="gene ID" value="AciX9_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1689"/>
    <dbReference type="eggNOG" id="COG1482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020529_0_1_0"/>
    <dbReference type="OMA" id="DTFFINT"/>
    <dbReference type="OrthoDB" id="645703at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="31990" checksum="6026FFB3E745F47A" modified="2011-04-05" version="1">MTITSDFEFKPFLMEPTFAERVWGKLDLKPWYEETGFKTAVGEAWLTSPAGKILTGELKGKTLAEVAPDFSLLVKMLFPADKLSVQVHPDDEQAQALGMPRGKTECWYVLEAVPGAEVACGLKSGVGVEDVRKAIADGSLEGLLEMVPVSVGDMVFVDAGTVHAIGAGVTLLEVQQTSDTTYRLYDYGRPRELHLEQGLAVVKTETKAGKIEPEEMDGFTRLIETKYFVVDRFDLPAGTAMEMPMDGVGCVVGIVGSGAVNEVRFGVGQAVVVPDSSVTMTTQHGASFLRCYEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF9</accession>
    <name>E8WYF9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ordered locus">AciX9_2842</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2842"/>
    <dbReference type="EnsemblBacteria" id="ADW69865">
        <property type="protein sequence ID" value="ADW69865"/>
        <property type="gene ID" value="AciX9_2842"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2842"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_0"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="18745" checksum="F480559723568351" modified="2011-04-05" version="1">MLLFVMHTVKAIYPGTFDPLTNGHLDLIARGAKIVDELVVAILRNSEKGTPLFTVPERLEMIAEAVSGMPNVSVTTFDGLLVDFARQQGARAVLRGIRAISDYEYEFQMAMMNRKLDPELETLFMMPAEKYTYVSSRLIKGVFRLGGDVTSLVPPLVVERLKAKGPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI6</accession>
    <name>E8WYI6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0512</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578912.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0512"/>
    <dbReference type="EnsemblBacteria" id="ADW67584">
        <property type="protein sequence ID" value="ADW67584"/>
        <property type="gene ID" value="AciX9_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0512"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OMA" id="NSWKWVD"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233984" description="PBP_domain domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="27"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="34550" checksum="06FBD753E3D3436C" modified="2011-04-05" version="1">MIRRLLLVAVLTCSGTAHAQTFAPSHVGPGVIRSWGDDQMAGVLTAWQQAFRRYHPDITFTQSLYGSGAGMAGIITGTSDLSLMGRPVTANEVIGFEWVFRYKPLQIQVLTGDLQQDEHSPALAVFVSSQNPLRSISKQQLIEILGCPGMPSGATTWASAGVTGPWASRPIHAYIPDEETGTGAFLQQTLLGLGDRWNWSLVREFHDTPNQPWGAQTIAALRQDPNGLAISTLIHAASGAKLLQIDGLSPSRETLVSARYPLTRGVYIDINRKPDMPVSPRVAEFLRFILSPEGQRVAAAQGSFLPLSGADAAKQAQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL1</accession>
    <name>E8WYL1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S9, prolyl oligopeptidase active site region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0537</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0537"/>
    <dbReference type="MEROPS" id="S09.012"/>
    <dbReference type="EnsemblBacteria" id="ADW67609">
        <property type="protein sequence ID" value="ADW67609"/>
        <property type="gene ID" value="AciX9_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0537"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_2_0"/>
    <dbReference type="OMA" id="YKHWDEW"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233496" evidence="3">
        <location>
            <begin position="19"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="573"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="802" mass="88900" checksum="0E0EDC888133E101" modified="2011-04-05" version="1">MSWIRVFFVMMVGLGSVAMGQAAVEPTSQNRDMGHPAKRAMTFQDLMAMKRVSDPQVSPGGKWVLFSVTDVSLAGNTKVNHLWVVPLQPTSENPDMGHPVVERQITFSTGESFGRFSPDGQFVSYTGAPMKDDPYSRITIATWDEKTGTIGMGRTLQAVSGDADGAVWSPDNKRFLFTTQVYPECSDKAKWSEEDACDKAKDEAADKSPVKAQLFTGLLYRHWNAFTGQKRTHVIVADFSLAGPNPRDLTPKSVVGDAETPTFSLGGPLGYAWAPDGKEIAYVTNLDTVPAASTNNDVFTLRLDEAGARPVKVSTSLGSDDGPAYSPDGRWLAFRSQARAGYESDRFRLMVFDRQAKTIRELMPKFDRWVDEFVWAGDSQALYFASGVSGSEQVFSIGLSGNELNLRTFVDSRGEWGEFAELNISHDGTFLVSSRSTVANPTELFLTSFVVDRDLNIDTVDAVGADGQAHKPEAGTYESAEYGIYKTTQLTRINRDALGAFKIYGGGDASSPFRVYDVGKHEGQPMESFTFLGDEGTKVQGFVVKPPNFDPKKKYPVKFLIHGGPQGAWGDAWSYRWNPELMAASGYVVVMVNPRGSTGYGQAFIDGVNGDWGGKAYVDLMKGLDAAEMQFPFIDKDRECALGASYGGFMANWMLTHTNRFKCIVTHDGMYNPAAAYGDTEEMWFNEWEFRRAGEKEPGQPWRYASLPADQDPFRKWSPMLSIQNAKTPTLVIHSQKDYRLDVSEGFQLFTALQRLGVPSEMLYFPDEGHWVTKPQNAELWNKTVSDWCDKWTHTNAYAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL8</accession>
    <name>E8WYL8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578944.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0544"/>
    <dbReference type="EnsemblBacteria" id="ADW67616">
        <property type="protein sequence ID" value="ADW67616"/>
        <property type="gene ID" value="AciX9_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0544"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_0"/>
    <dbReference type="OMA" id="TLNMVYL"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="34307" checksum="62FEC5B6BF5A7B98" modified="2011-04-05" version="1">MTQSRLSPRVLIAFACVYFFWGSTYVAIRFGVEVLPPFVLAGVRFMIAGPLMLLVCAARGLKLKQSPRDFAWLAVIGILMLGVGNTSLVWCEQFLSSGLSSLLLAVIPLYVALFEVFLPRGEGLRAKGWLGITIGFAGLVILVWPGLLESLHGSRTQLIGTIVALMGALSWTSGSILSRRTSLATTAFVAAAWEMVFAGLFNTSVMLATHSYRDIHWNTQAVLSIAWLVTFGSIVGYTAYIYLLDNVPVAKVSTYAYINPIVAVVLGAIFLHERMVPIEYAGMAAILIAVYLVTSSKLRSGKEVAEIECTVTEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN9</accession>
    <name>E8WYN9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0566"/>
    <dbReference type="EnsemblBacteria" id="ADW67637">
        <property type="protein sequence ID" value="ADW67637"/>
        <property type="gene ID" value="AciX9_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0566"/>
    <dbReference type="eggNOG" id="ENOG503133D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530445_0_0_0"/>
    <dbReference type="OMA" id="HIETEMR"/>
    <dbReference type="OrthoDB" id="1796343at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="19001" checksum="C2482EB63019CD5E" modified="2011-04-05" version="1">MPNSPRLRAILIAVLLMPLALLAQPRPKSSWRAATPAELESVLPARAPVEKERIETELRTATGITDAHGHTIAAVVLITAGYAANGKYSHFLLVQSPLALGPDLHLVPGSYVLGWTRTEDGLLVHVFEAATGTERGTFVARIPKTPTKVEPFKIWPPADRSVIQIGRFLAPYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ2</accession>
    <name>E8WYQ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HPr(Ser) kinase/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0579</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0579"/>
    <dbReference type="EnsemblBacteria" id="ADW67650">
        <property type="protein sequence ID" value="ADW67650"/>
        <property type="gene ID" value="AciX9_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0579"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836602_0_0_0"/>
    <dbReference type="OMA" id="PRVIGHA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="357" mass="39154" checksum="0FA08C0BD0A7B94C" modified="2011-04-05" version="1">MTTAALHSMQLPRPIQEEQVEPLLASDGFSFRRVFYPMGFAVEIETNQAEILAAAEESWGEQDAIAVPRQIAGALKLRVGVTPSSSSECPPKTSVRANGHLLSIIADIENFSVCDLQQGVAFGWVTEAALHHRHYLRYHFLEATVMCLLTGSRVTPVHAACVSLNGFGLLLCGESGAGKSTLAYACARAGWALTTDDASYVVWHSDQPHVRGNAHQVRFRPSARDLFPEIRDRELTPRTDGKPSIEVPTSELPGIVKAPQAVVHAILLLKRRAEATVELREVDRRTVLPHLEGSLYPLEGIRQRQAAALTSLDGVALYEFHYRDLDCAIAQLEALTEALAKTSPEARQTDDNTRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU0</accession>
    <name>E8WYU0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1728</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580095.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1728"/>
    <dbReference type="EnsemblBacteria" id="ADW68776">
        <property type="protein sequence ID" value="ADW68776"/>
        <property type="gene ID" value="AciX9_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1728"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="80"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="35340" checksum="E5EE64084778CE51" modified="2011-04-05" version="1">MAHDDEQGGTGVPDNEPEQKVPGSEAEQRGDVDGETPLTAEVSPDVAEAVGEFMERAAAQNEAAAEEIPDTKNHKPGSYISFEKVSKSFGAFDVLKSVSFCVNPGETLCILGRSGVGKSVSLQMLLGFLRADSGTVRIAGEDVTNFSEKQMQAIRRKVTMVFQNGALFDSITVGENVAFPLRERGDMEEDQIYQVVKGLLEMVGVAGMDHLLPSDLSTGMKRSVAIARALAAQPEAVLYDEPTTMVDPLMAHLLGNLIERLKQQLHLTSIVVTHDMRFAKKLADRVVFLHEGEAKFFGTMEEMEKSDDPVLREFLTLDELVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU1</accession>
    <name>E8WYU1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1729</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580096.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1729"/>
    <dbReference type="EnsemblBacteria" id="ADW68777">
        <property type="protein sequence ID" value="ADW68777"/>
        <property type="gene ID" value="AciX9_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1729"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_0"/>
    <dbReference type="OMA" id="RPHALQH"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="309"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="501" mass="55768" checksum="2DA081E86C4D278E" modified="2011-04-05" version="1">MATPDYLQQVIVSGRRSGGGRANSARRRVFQRPSVTSLVWATLDLLTVVVAAVMAQRLQMGNSADHPGSLLPQIFTQTPKLWLGYLAWFGGTLVFFARSYGLYGPIQNRSGLHEQRMTVQATLTSGLLLCGALYVLRGDNVPRVVVLLLVGITAVLLSVRRAIWRSMEYSRYREGLETRNVLIVGAGRVAHALRNHLESLRHLGFRFKGFVALTEREAESGDADVIGDIKNCLSLARALFVDEIFFSVPADKKLVIALVEEARAVGIDVRVVPDLYDGLAWNAPVEYIGQFPTIPLHRRDFPIGSFLMKRALDIMLSSIALLVASPILAGIAIAVRMDSTGPIFYKAARIGRKGRTFNCFKFRTMVPNADHLKASLEHMNEREGVLFKIVNDPRITKVGRVLRKYSLDEIPQFYNVLRGDMSLVGPRPPIASEVEQYDLAHLRRLDVLPGITGLWQVEARQDPSFDSYISLDTAYVENWTFWLDLKILARTVGVVFSGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ72</accession>
    <name>E8WZ72_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579002.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0603"/>
    <dbReference type="EnsemblBacteria" id="ADW67674">
        <property type="protein sequence ID" value="ADW67674"/>
        <property type="gene ID" value="AciX9_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0603"/>
    <dbReference type="HOGENOM" id="CLU_2788054_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7013" checksum="ABBCD67F0E5C039E" modified="2011-04-05" version="1">MSANDTVTQTLPDVPVPPVQPVAVDVEAVAAEAVSADVQADLSMEPPPPPRAEAMPIVKMSNPHESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD7</accession>
    <name>E8WZD7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1777</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1777"/>
    <dbReference type="EnsemblBacteria" id="ADW68825">
        <property type="protein sequence ID" value="ADW68825"/>
        <property type="gene ID" value="AciX9_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1777"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833581_0_0_0"/>
    <dbReference type="OMA" id="VNGWIAT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="333" mass="35883" checksum="DEAC599E46D2EFDC" modified="2011-04-05" version="1">MLSSLSLFGRVGLGLALVGTGFAQGPLTAGTATSVAGRSAALSSLFKEMWDDELKHSPEFASELGDRRYGDQLSDLSPRAVNDGLARGQGYLVRLAEIDTTGLSADEKLAVETMEERLAAAEEGARAKAWEMPVTQAGGVQVVLPGLAASLSFETVKDYDDWITRLKKIPDQIRQATEDMMAGIDERRVQPVAVLEMAEKQTEDLAGQKPEESVFARPLKRFSASIGAAERKRITDETLDAIQDDVLPAYVRFGKFLKVQAVPAGSPDGKASAVAPSGQRLEEAKILELRAKAKGSLGARFDSKAFADLIAKDYVLPMKGLEERVNGWIATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT0</accession>
    <name>E8WZT0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0671</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579069.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0671"/>
    <dbReference type="EnsemblBacteria" id="ADW67741">
        <property type="protein sequence ID" value="ADW67741"/>
        <property type="gene ID" value="AciX9_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0671"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="LTEMAPI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="262"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="482" mass="54015" checksum="58F786170A0CAE07" modified="2011-04-05" version="1">MAQFFDAATDAIFFLDRDYRFTFLNRRAFEVLAPGGGDILGRVLFELYPDTVYEGSPYVKAYEGSMERREVGEFEAYYPEPFNFWLRVQSYPADDGIIVFFRDVTQDRLLHESLRSKSEEEERQRAEIESVYANAPIGLALFDLNDYTYLRLNDRQAAFFGKRPEEVVGRTLTEMAPIEGLRELFDGVAAGVPVINFPLVGALVTDPDTVRYWTVSYFPVTSSDGTVTGITAASLEVTHQKKTEMALIQSEKLAAVGRLASSIAHEINNPLEAVTNLLYLAERTDDLTEVRQYLRDAEVELRRVAAITAQTLRFHKQSTDAQAVTMEELIRSALSIFQGRLANSPIEVVECFHAQQPVRCFEGEIRQVLSNLLGNALDSMSAEGGRLLIRTQTATNWRTGDRGVAILFGDQGTGIDAKFRAKLFEPFFTTKGIMGTGLGLWVSKGIIDRHHGTIAVRSRQMPGASGTIFRIWLPFDAAVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX1</accession>
    <name>E8WZX1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0712</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579108.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0712"/>
    <dbReference type="EnsemblBacteria" id="ADW67782">
        <property type="protein sequence ID" value="ADW67782"/>
        <property type="gene ID" value="AciX9_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0712"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192709_0_0_0"/>
    <dbReference type="OMA" id="NWIHPFT"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="24425" checksum="CF29E9A9A4C3A56D" modified="2011-04-05" version="1">MAEEIRHSKADEAVVVTDPKLAAELEAANGLKQYNLVTDMVQAFLDPERPFRLRPSHIQGLHRAALQGLTGYAGNWRPSKVGIQGSKHAPPEAFEVPERIEELCDYVNDRWKDKSPIHLAAYVMWRLNWIHPFTDGNGRTSRAVSYLVLCVRLGYLLPGHLTIPDQIEAEKTPYYKALEAADVAWAENRVDLTAMKGLLSTMLAKQLLAVHQESGSGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X019</accession>
    <name>E8X019_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Soluble ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1869</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1869"/>
    <dbReference type="EnsemblBacteria" id="ADW68915">
        <property type="protein sequence ID" value="ADW68915"/>
        <property type="gene ID" value="AciX9_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1869"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_0_0_0"/>
    <dbReference type="OMA" id="TKGGQFY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230124" evidence="3">
        <location>
            <begin position="30"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="36890" checksum="FBDCE4A58587D9BE" modified="2011-04-05" version="1">MRRCTTQVSSAALLTLTLGFAIPCAGSLAQQPDAAATVPLKTNPMLSLREFEPEANAEYILGRGDEISIDYGGRPELNSKNVIGPDGKVTLPMAGSIFLADKSRQEAADAVVAALKPFYASLSVTVGVDKYTSNQVLLLGAVEHPGVQTFDRPPTLLEVVTRGGASGNPRSNSGGGTGSTAFSMQASLQPAMLGVPERCAIYRGSDKVLWVNLKSLLDSGNALADIRLKRDDIIYVPSPAERYVSVLGQVQHPGALQLDSTSTLPKLIALAGGLTQEAGGNPNIQVIQIVNGKTRIVPFKQILQPSPLDLTLQSGDIIFIPESGFNKAAYIIDKLSPAITLFTGSALISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X057</accession>
    <name>E8X057_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3017</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3017"/>
    <dbReference type="EnsemblBacteria" id="ADW70038">
        <property type="protein sequence ID" value="ADW70038"/>
        <property type="gene ID" value="AciX9_3017"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3017"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="EFEIFRL"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26167" checksum="4A168AF466DCAE8D" modified="2011-04-05" version="1">MLKTASAEKTPVRRKAAPAAGSIRIVVADDHPVVRFGVKNMLMNEPGFEVVGEAEDGDVAIQQALELEPDILLLDLNMPRLPGLEAMRAIMTKSPRVKIILLTATISTQQIIEALQIGARGIVLKDAVSGDLSEALRAVLSGDYWIGGERVANLLKALHELMQKAAQVPERKTYGLTPRELEVVQCIVEGCSNKDVAKQFTISEETVKRHLSNIFDKTGVSTRLELALFAIAHKLVTPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A6</accession>
    <name>E8X0A6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581401.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3067"/>
    <dbReference type="EnsemblBacteria" id="ADW70087">
        <property type="protein sequence ID" value="ADW70087"/>
        <property type="gene ID" value="AciX9_3067"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3067"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2395589_0_0_0"/>
    <dbReference type="OrthoDB" id="1912947at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="9979" checksum="598520BE2AB31442" modified="2011-04-05" version="1">MPFMYELTLAPGEPEYTFVQQLVPVGTLVSTGQPVATLTDGAMEYHVPAPRQGLIVQWFVEHGGRVAGNDGLARIVCEGEAEEVPPASPMRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B7</accession>
    <name>E8X0B7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3078</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581412.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3078"/>
    <dbReference type="EnsemblBacteria" id="ADW70098">
        <property type="protein sequence ID" value="ADW70098"/>
        <property type="gene ID" value="AciX9_3078"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3078"/>
    <dbReference type="eggNOG" id="ENOG5032UUM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2221493_0_0_0"/>
    <dbReference type="OMA" id="EEHESGA"/>
    <dbReference type="OrthoDB" id="1970592at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11249" checksum="3C67A8582A972823" modified="2011-04-05" version="1">MNQNVKNLIQKLGEAIHESVSESEHIAGVVKNLREQGFDVLLMLEATIGLNEVEEETEDSPLLLGDGTTEEGPFTNNDLSFLKSLRISLAEEGQEQGLEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E8</accession>
    <name>E8X0E8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0742</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579138.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0742"/>
    <dbReference type="EnsemblBacteria" id="ADW67812">
        <property type="protein sequence ID" value="ADW67812"/>
        <property type="gene ID" value="AciX9_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0742"/>
    <dbReference type="HOGENOM" id="CLU_2788055_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7686" checksum="0518668E57B4E3FF" modified="2011-04-05" version="1">MSNALPYLIPTFAVLLGVLFTRQDINALRAELKAELKSEIGQLRSEIITLRDNIHRDMIGLHERVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J0</accession>
    <name>E8X0J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0785</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0785"/>
    <dbReference type="EnsemblBacteria" id="ADW67854">
        <property type="protein sequence ID" value="ADW67854"/>
        <property type="gene ID" value="AciX9_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0785"/>
    <dbReference type="HOGENOM" id="CLU_2825089_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="5941" checksum="5617BF7DB16F68B7" modified="2011-04-05" version="1">MPALKEFIPRLGAQTESICSTCCQVIRPNPSAPTLEQAQAQHHCGEFSLNTTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K8</accession>
    <name>E8X0K8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1913</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1913"/>
    <dbReference type="EnsemblBacteria" id="ADW68959">
        <property type="protein sequence ID" value="ADW68959"/>
        <property type="gene ID" value="AciX9_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1913"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_2_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10493" checksum="CA23FF4ECB481D69" modified="2011-04-05" version="1">MAMTRMHNPPHPGTVLKSYLEGHTIGSVAAHLGVSRVTLTRILGGHSAITAEMSIRLGEALKTSGEFWFTMQNNYDFWVASQVKRKKVTPLREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S1</accession>
    <name>E8X0S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1976</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1976"/>
    <dbReference type="EnsemblBacteria" id="ADW69022">
        <property type="protein sequence ID" value="ADW69022"/>
        <property type="gene ID" value="AciX9_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1976"/>
    <dbReference type="eggNOG" id="ENOG5030PKT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153891_0_0_0"/>
    <dbReference type="OMA" id="FLWGEFD"/>
    <dbReference type="OrthoDB" id="2076213at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="15795" checksum="BD0B85FB56249A97" modified="2011-04-05" version="1">MSLPKKQHWHTRAFHPFLVDRAQTPFAWGTNDCALFSADAILANTGVDIATDFRGKYTDKRSAFLLIRSLTGGSTVADAAAYCAQKHGLVEHQHPLMAKRGDLVVVADGDELICGVVHLSGHVISVSESDTVRLPITKVVRSWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V4</accession>
    <name>E8X0V4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3122</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581452.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70138">
        <property type="protein sequence ID" value="ADW70138"/>
        <property type="gene ID" value="AciX9_3122"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3122"/>
    <dbReference type="HOGENOM" id="CLU_2355772_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="10405" checksum="FDE39B1D003EBF63" modified="2011-04-05" version="1">MCEIVIIVVAAAYLLPGCTRTAGYGLSLSEIGSVFLGKQNAYPRRANNGRRAVRRVVEHQAKQICAAISVMLFGCTDPDHHLCTCRMTVIIGSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X4</accession>
    <name>E8X0X4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3146</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581471.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3146"/>
    <dbReference type="EnsemblBacteria" id="ADW70158">
        <property type="protein sequence ID" value="ADW70158"/>
        <property type="gene ID" value="AciX9_3146"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3146"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_0"/>
    <dbReference type="OMA" id="DDPMMQL"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="23543" checksum="27A14F1534147B4C" modified="2011-04-05" version="1">MDEMPRIRILSVEDHPVFREGLRAVLSLQPDMELATVASNAVEALEQYRRHAPDITLLDLRLPGTDGFATLAEIRQLNPDARVIILTTSEDDADVRRAMRGGASAYVLKSLPMQELVVTIRSVYSGTKHVPHEFAARMAERFGDEKLTDRELDVLKLIRDGRRNKQIASDLKIAEATVNFHIKNISQKLQANDRTHAVMIALRRGLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X101</accession>
    <name>E8X101_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name evidence="3" type="ordered locus">AciX9_0799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0799"/>
    <dbReference type="EnsemblBacteria" id="ADW67867">
        <property type="protein sequence ID" value="ADW67867"/>
        <property type="gene ID" value="AciX9_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0799"/>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_2_1_0"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="170" mass="18530" checksum="CC985E5B210562E9" modified="2011-04-05" version="1">MLIWLTGLSGSGKSTLARQVFETLAAAGCRVELLDADEVRAQLSSGLGFSKSDREENVRRLGYVGGLLRAHGVIVLVAAMSPYRAGRDEIRKTAPSAFVEVFVDAPLAICEERDPIGLYRRFRAGEVHNLSGLDAPYEPPLNPEVHCHTAQQTIEESVADILKTVRPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K5</accession>
    <name>E8X1K5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ordered locus">AciX9_3229</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581552.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3229"/>
    <dbReference type="EnsemblBacteria" id="ADW70240">
        <property type="protein sequence ID" value="ADW70240"/>
        <property type="gene ID" value="AciX9_3229"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3229"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_0"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="389" mass="41726" checksum="FC2AC981321AA6E4" modified="2011-04-05" version="1">MKIHEYQAKEILRKYNVPVPGGEMATTLEEADTAAKALFAAGNTVVVVKAQIHAGGRGKGGGVKVAKSLDDANTASKAILGMQLITHQTGPTGQKVQRLLIEEGSLIDRELYLGLVLDRASAKVVFMASQSGGMEIEEVAHATPDLIYKEYVDPVVGLQPWQARSLAFKLGLTTAQINPAVSFMMGLYKAFIETDSTLMEINPFITTKDGKLMALDCKINFDDNAMFRHKDLKELRDLAEEDPLEVEASKFALNYIKLDGNIACMVNGAGLAMATMDIIEYAGGKAANFLDVGGGANQEQIENAFGILLSDPNVKAIFINIFGGILRVDVLATAVVAAARKLNVQLPIILRLEGTNVEEGRKILAESGLKFEVGTTMKEAADLAVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L5</accession>
    <name>E8X1L5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3239</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3239"/>
    <dbReference type="EnsemblBacteria" id="ADW70250">
        <property type="protein sequence ID" value="ADW70250"/>
        <property type="gene ID" value="AciX9_3239"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3239"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="RVYGICY"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="30532" checksum="599E683FB4A4ECEC" modified="2011-04-05" version="1">MGVLHMTMPFLQTLPTQGKLLGGWMPRSRPGSGGGGEEPPANAGRLPGGTLLPTPQSPESRVPEARLQRTPEQQAEQDALAALVRQCMAGDQRAWHLMLTSQQKRVYGICYRFSGNQTDAEDMTQDVFLKIYRNLGSFDPDKGSFQTWITTMTRNMLVDQFRRTKLERATDSMDVSATGEEDGPTQLERLPDTRPSQEQNYAGLELKAKIQDALSKLSPELREAVILRDLEDMDYKEIALVLKIPEGTVKSRISRGRAELARMLQRIDRQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W3</accession>
    <name>E8X1W3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2079</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580441.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2079"/>
    <dbReference type="EnsemblBacteria" id="ADW69124">
        <property type="protein sequence ID" value="ADW69124"/>
        <property type="gene ID" value="AciX9_2079"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2079"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_0"/>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="43"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="40240" checksum="E02DCFA0261C79D7" modified="2011-04-05" version="1">MPILTARTLITAIGTVEYPAITIGPTGLIEDISTDPTIRSTAILTPTFLDIHFHGAAGEDLMAATPEGISKIQRFLATRGTSHYLPTTVTAPIDDTLRALEHLADAIEHPSAPGEATPLGIHLEGPFLSHIKRGVHPTELLQKPSIALFDRFQQAARGHIKLLTIAPESEGALELITYATHQGIRVTMGHTNATAAETNAAIVAGATSGTHTFNAMRALDHREPGIVGVILDRDDLFSDLICDGIHVAPALVRLWFRLKQEKAILITDAMSATGMPDGEYHLGSFAVTVKDHRCTLTDAPDTLAGSVLTLDQAVANLQSFTNATLAQAVRCASSHPARMLGLEDTIASLRPGQPATFNQYTPEGRLEATYLQGHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X3</accession>
    <name>E8X1X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2090</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2090"/>
    <dbReference type="EnsemblBacteria" id="ADW69134">
        <property type="protein sequence ID" value="ADW69134"/>
        <property type="gene ID" value="AciX9_2090"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2090"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303215_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="982" mass="106283" checksum="A04FAE536BDED712" modified="2011-04-05" version="1">MAQPALATTTDLSLDPSSPAARATLRAQAHAMLDDMLDYSENIRERQVWQVILPEIRANFQSPIPTQPSALAEVHQQFMTSILPFTAANTHPGFMGWAQGGGSQVGMLAGMLTAGLNANVGGRDQIPLEVERQVTAWMRDLFHFPAEASGIFLTGTSIANLLAVVIARDARLGPGIRQTGLTSPTLISYTSSAAHNSIAKALDLAGLGTGTLRLIPTDPAGRMDLAVLDQAIQQDRAAGLTPFFIAATAGTVDIGAIDDLESIADLCAQHNLWFHVDGALGALAMLAPGLAPRLKGIERADTLAFDFHKWAQVPYDAGFLLVRDAQLHQQAFASPACYLARENRGLAANSPWPCDLGPELSRSFRALKVWMTLKVQGTDAIGAVIQNTCNLAQSLATRIRNTPELELLAPVQLNIVCFRYRFTDQSETDVSHLNRELVIRLQESGIVVPSATTLASRVAIRAAIVNHRTTQSEIDDLVEATLSLGRELQPTPHPVSWPPTLQLEAELLQLSHQLPATLDPADEIALRVQRAILLAQLGRPLEARSDHLRVLELDPTHHANLLELGRLLAGTGQTKAAQVVYTEAVKHYPHDAVAHVNLGSTLLTNDDPSKASHHYELALQLSPGLPEAHGGLYYALTRLGDPDAAALHRQKAFGRKNIFQTPFRGTAHPIPVILLVSSTGGNTPVEKLLDDTIFQTWVIVADFYDPQTPLPPHQLIFNGIGDVEVASEALIAARTLLAQISRPILNLPSAVLATSRPENAARLAALPSVRTARTRSYPLTFLAGDHALPTLATDGFTFPLLLRLPGFHMGQHFTQVDEPSALAAHIAALPTFGHADAEVLAIEYLDARGSDGCARKYRVMFIAGELYPLHLAISPNWKIHYFSADMADRPDHRAEEAAFLSDMSTVLGPRAMSALASIQKTLGLDYAGIDFGLNLAGDLLLFEANATMVVEQPSPDPRWDYRRTAVDRIHAAVRHMLLNSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y2</accession>
    <name>E8X1Y2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69143">
        <property type="protein sequence ID" value="ADW69143"/>
        <property type="gene ID" value="AciX9_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2099"/>
    <dbReference type="eggNOG" id="COG1661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114051_2_2_0"/>
    <dbReference type="OMA" id="KPSIHAH"/>
    <dbReference type="OrthoDB" id="1752865at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="71"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="22369" checksum="12864FA1DF8A0994" modified="2011-04-05" version="1">MRKSWLWLGGGVLVMWLGWTVLMSLPQIVLGYLGMPWRVVSAASVDEVTISPSRAIPVGGAPGMQVTLVHENGGEKVYAVIFKKGDEVLSGLTDFAIQNHVGDAHFTGIGAVSGATTGWLDLSAKVYRGTVTKEQVEVLSLTGDIATFQGKPVVHGHVVLGRRDGSTVGGHLWEAKVNPTLEVFVTVDERALPKRLDDESGMKVIDAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B3</accession>
    <name>E8X2B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0978"/>
    <dbReference type="EnsemblBacteria" id="ADW68045">
        <property type="protein sequence ID" value="ADW68045"/>
        <property type="gene ID" value="AciX9_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0978"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153953_0_0_0"/>
    <dbReference type="OMA" id="NLSKTAM"/>
    <dbReference type="OrthoDB" id="2032706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13852" checksum="46095B6E3A688A29" modified="2011-04-05" version="1">MRSKMSKEKQPESIHTGSTFESFLEEEGIRNEVEGAAIKRVLAWQFEQAMEKQKKTKQTMARELKTSRSQLDRLLDPTNTAVSLETLTRAANVLGKRLVFEIRDHAPVKKPRTHSATATIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J4</accession>
    <name>E8X2J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2174</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580534.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2174"/>
    <dbReference type="EnsemblBacteria" id="ADW69218">
        <property type="protein sequence ID" value="ADW69218"/>
        <property type="gene ID" value="AciX9_2174"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2174"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033708_0_0_0"/>
    <dbReference type="OMA" id="GQIRYHH"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="298"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="621" mass="66353" checksum="D5D4DC2908C7F423" modified="2011-04-05" version="1">MLLLFLAYFGGILTILSPCILPVLPFVFARSDQPFRKSGLPLLTGMALTFALVASLATVGGGWAVRANQFGRGAALVLFGIFGLTLLFSSLAERVSRPIVQLGNRLSRTTDDGPSMANSFLLGIGTGLLWAPCAGPILGLILTGAALGGASVHTVFLLLAYAAGAATSLTLALLAGGKVFAAMKSSLGAEEWIRRILGVAVLAGVVAVTFGLDRGILTRLSLSSTANLEQGLLDRFHPQKAETATKDEAIAPSTAMMAGSGAMMAGNQPAMAANNAMMAANQPAMSGNNAMMAAGGAPPAADTVPTGDLSGATAWINSQPLTLAALHGKVVLIDFWTYSCINCLRTLPYIKAWNEKYKDSGLVVIGVHTPEFPFEKDESNVRKAVRDLGVTYPVAMDNDYRIWRSFNNEYWPAHYFIDATGKVRYHHFGEGGYEESENWIRSLLEEANHKPLPGSATQISASGAEAAADSNDVQSPETYVGYHRAEHFASPGGFNQNEPQAYEAPATLKLNEWAFAGQWQDERQIATSLAPASAIVYRFHARDLHLVLGPSKAGKPIRFRVTIDGKAPGADHGMDTDADGYGTVTSDRLYQLIRQQGKVQDRTFRIEFLVPGVQAYSFTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R6</accession>
    <name>E8X2R6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_3355</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581675.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3355"/>
    <dbReference type="EnsemblBacteria" id="ADW70363">
        <property type="protein sequence ID" value="ADW70363"/>
        <property type="gene ID" value="AciX9_3355"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3355"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_1_0"/>
    <dbReference type="OMA" id="LCGQPWF"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="124"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="31678" checksum="3BBA4D09D8315993" modified="2011-04-05" version="1">MDWKSKRIRTILEGALIEDKAAFDVTTALTINPRLRATGTIIAKEPCVVAGLGAIPVFLELFTALAEKAGHRPLGRFEVIHHPEIFDGVRVKKGATIAVIRYNASALLSTERVILNLMQRMSGIATLTQEFVKAVAGTKTKVLDTRKTIPGLRALDKYAVCCGGGVNHRLDLQDGILIKNNHISLGGGLPAALAAALKNRPHNQPVQVEVRSQQELDEAIAGGPDSILLDNMTPAATKKAVKQIRAALPNLPIESSGNMSLATVRDYAMAGVDFVSVGALTHSAVAVDLSMKIAADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X312</accession>
    <name>E8X312_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1083</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579469.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1083"/>
    <dbReference type="EnsemblBacteria" id="ADW68146">
        <property type="protein sequence ID" value="ADW68146"/>
        <property type="gene ID" value="AciX9_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1083"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_0"/>
    <dbReference type="OMA" id="VQVWHVY"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="45540" checksum="B5F56F0456D08CBB" modified="2011-04-05" version="1">MSSFSHAWRALRHRNFQLFFFGQSISVIGTWMTRLATTWLVYHLTHSALLLGVVTFSGQIVSFLLGPFAGVWVERFERRQLLIWTQAAAGIQSFALAALTLAHIITLPEIIALTALQGVINAFDMPGRQSFLVQMVEDRNDLSNAIAINSSMANGARLIGPAIAGVIVAVYGEGTCFLIDGLSYFAVIASLLLMHIKPLNLSRSKATMWEQMREGWDYVSTFRPIRTILLLFALISLLGYSWSVLLPLFAAQVLHGGAATLGWLMGASGVGALTSALSLAFRKTVVGLTRMLQVASAMLGVALILFGLSHTFWLSMVLIALVGFGMLQAASVSNTVIQSLVPEDKRVRAMSYYTMAFFGASPFGSLFAGALADRIGAPHTVMITGALCLAASLWFTFELPKIRAIIRPIYQQMGLIPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X336</accession>
    <name>E8X336_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2217</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580576.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2217"/>
    <dbReference type="EnsemblBacteria" id="ADW69260">
        <property type="protein sequence ID" value="ADW69260"/>
        <property type="gene ID" value="AciX9_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2217"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="FPQWGAY"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="25243" checksum="19D02EC64ED7D796" modified="2011-04-05" version="1">MSKLKDKIALVTGASRGIGAAIAKHLAADGANVAITYAKDATAAEAVVKAIEALGRKAFAVQADAADPVAVKAAVDQTVKTFGRIDILVNNAGTAIPKPFEDATLEEMDRVLDINVRGIFAATQAALKHMPNGGRIISIGSCVGERNFTPGLAVYAATKGAVKMFTQGLAREVGDRAITVNNVQPGPIDTDLNPAAGDWAAPQLANTALHRYGHVDEVAALVAFVASPEASYITGANLTVDGGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X352</accession>
    <name>E8X352_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ordered locus">AciX9_2234</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580592.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2234"/>
    <dbReference type="EnsemblBacteria" id="ADW69276">
        <property type="protein sequence ID" value="ADW69276"/>
        <property type="gene ID" value="AciX9_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2234"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_0"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="188"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="343"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46281" checksum="A4C2F78D7F40158E" modified="2011-04-05" version="1">MSESNIQPDQKTPTLVLLGVNHNTAPIDIRERLAIPAGRLADATRSLAHSPGIREGLILSTCNRVELLTVQDGPTPETSPDLLRFLHEYFSVPSATILPHLYEFREREAVRHLFRVASSLDSMVVGEPQILGQVKDAYTIAKEVGSIGGTENGQLDTLLQKAFTVAKKVRSETQIGSSVVSIASVAVDLARKIFGSLANKTILLVGAGKMSELAVSHLIQHGAASILVANRTEARAQKIAQQFATPGVTCTVIPFDDLYTQAHQADIVITSTGATEQLFARQHGQQFIAKRRGRPMFFIDIAVPRDVDPRINEIEGCFVYDIDDLQQVAQSNQANRSREAEAAERIVTNEVESYQQRLVSLVAVPAIKALQQQAEQTRQSELARAAKALGTLTPAQQEAVEALTRSLTNKLLHPQLVALRKPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J7</accession>
    <name>E8X3J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579511.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1125"/>
    <dbReference type="EnsemblBacteria" id="ADW68188">
        <property type="protein sequence ID" value="ADW68188"/>
        <property type="gene ID" value="AciX9_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1125"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045947_0_0_0"/>
    <dbReference type="OMA" id="VLQHGWP"/>
    <dbReference type="OrthoDB" id="587274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233629" evidence="1">
        <location>
            <begin position="18"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="367" mass="40109" checksum="CC9E92C6A9FF5A91" modified="2011-04-05" version="1">MRLPLILLLATTAAAQAPLKLNQIQVIGTHNSYHAGIAPNESKIWQAKYADAYKGLDYQHKPLPDQFDAGVRQIELDVYADTKGGLYAHPSGPTMTAAAHLPADPEFDPNGIMAKPGFKVMHVQDVDYRSTCQPFTACLEQVRQWSHAHPRHVPIFILVETKQGKPRGELKLTEPETFTSATFDALDAEIRSVFPASELITPDDVRGKHKTLNEAVLAGGWPALASARGKVVFLMDQHPVTPVYLEGHPSLRGRVIFTNSDPGQPDAAFLERNEGPASEIEALVKQGYLIRARTDADTKQARTNDTALRDAMMSSGAQLLSTDYPANEPARWPGNFSVALPNHAVARCNPINAPKDCESSLEADPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X413</accession>
    <name>E8X413_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3516</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581832.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3516"/>
    <dbReference type="EnsemblBacteria" id="ADW70521">
        <property type="protein sequence ID" value="ADW70521"/>
        <property type="gene ID" value="AciX9_3516"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3516"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132147_1_0_0"/>
    <dbReference type="OMA" id="WVITHDH"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234341" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17270" checksum="AD311979E6BB1653" modified="2011-04-05" version="1">MKTLFLLALILCLPLAPAVRAQDKGPDQLRTLSHDELAIIKVLNAQEKAWNRGDIDSYVTGYKNAPDILFVGAQVSHGYAQMVSDYRHNYPNRDAMGTLTFADLEPRLLDEKFAVVLGKYHLDRNKKAGGPADGIFSLIFEKTEGGWKIIVDHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X428</accession>
    <name>E8X428_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3531</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581847.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3531"/>
    <dbReference type="EnsemblBacteria" id="ADW70536">
        <property type="protein sequence ID" value="ADW70536"/>
        <property type="gene ID" value="AciX9_3531"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3531"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_11_2_0"/>
    <dbReference type="OMA" id="MEIKWLR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10560" checksum="9A1FAF835E12972C" modified="2011-04-05" version="1">MQLRWTPEAADNLEEIYDYYRNKSAVAAHPVIASIQAGLTQLQQFPYTGRLGIRPDTRELVLTGVPYLIVYRIRHDTVEILGIRHGARQIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X434</accession>
    <name>E8X434_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_0003</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0003"/>
    <dbReference type="EnsemblBacteria" id="ADW67094">
        <property type="protein sequence ID" value="ADW67094"/>
        <property type="gene ID" value="AciX9_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0003"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_2_0"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="273"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="397" mass="43821" checksum="44C6F9D26970EB40" modified="2011-04-05" version="1">MPTLTEDSETNTNVAAPTGNLEITVSRAELLRELTAAQSVVERKTTIPILSNFLFEASNEGETGRLTITATDLDQSLRTSCAAKVKKAGACTIPARKLYDYIRLLPEGEISIKLMDNHWVQIRAGRSNTKMVGMARANFPQVAEFPASGAYTLSVASLKTMVSKTIFAISNEESRYTLNGALLVLKAESMAMVATDGHRLAHVEKLGETLEGISGEKKTLIPRKALSELSSLLNSTDAETMQFADDDSTLFFKMGGRVLTSRKLTGQFPNYEAVLPRDNNKFVIVRSEDLMSAIQRVAQFADERSGAIKIRLEQNELRLSSSSTDSGESEDTIETPYNYDPLVVGFNSQYLIDFLKAIGNTGEVRLEFKDAQSAGQMRPEDGNEDVKYRYILMPMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X442</accession>
    <name>E8X442_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0011</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0011"/>
    <dbReference type="EnsemblBacteria" id="ADW67102">
        <property type="protein sequence ID" value="ADW67102"/>
        <property type="gene ID" value="AciX9_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0011"/>
    <dbReference type="eggNOG" id="COG4772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012813_0_0_0"/>
    <dbReference type="OMA" id="YHVPTDF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="345"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="865" mass="93480" checksum="149AB65E11460C92" modified="2011-04-05" version="1">MDDKGGLLPKASLTVKNDAGGAAQTAITDAAGRFTLSGLVAGSYTVQATAPGFNTITKNVRVTDGGTNEVSLSLSIGNLTDQVTVEANSQGSVAAALAPMDALLEATSARTEITSAFIQNFTSPVADFGEAVEMAPGTFTTNGNGVGLGQSSTYFRGFPDGDYDIDFDGIPFYDTNTPSHHSWAFFPSQFLGGIDFDRSPGTASTIGPTPFGGSIHLLSKQFSPMQNVRGGFSYGSFNTKLFDGEYDSGNFGPAHKFNVNVDVHHLGSDGYQTFNHQTRNAGDIQFQYRPSDKTTITGFSAVIWLDANTPNFAATRCQMYGAQAGYTCTGANAPFAGSGINFLLTNNSDPLLYLNNQYNYYHVPTDFEYVGVRSELGKGFTFSIKPYTYNYDNSEKYSNAVPITDNAALVGTTYAPLNVKIANTCSTLVKSKYTCGVDKYNSYRKYGETSELTQVSHFGIFRAGLWYEWANTNRHQYPADPLQNWLDAPLPNFAETFVTNSYQPFVEYQYHATPKLTITPGIKFAYYTIGTKQFADNGGKIGGLGSNNPAAFITNGGSYFSSLPSGDVNYRIRDNWSMYGQVATGSIVPASGTFDFTQSATGTPVATLPKQQKNLTYQTGTVLKLKRVTFDFDYFHIHFDSGYSSFTPIDTGEPVYYLQPPSVTQGIEGESNVYITHGLSLYLNASYNRAQYTGNATVFCNTAAACLSSTPQLSIATPGGQRISNAPSDIETEGLTYQHRSWDAGAFNKRVGTMSLDNSGFHNAGTIDPFTLTNVFLNYTIKSGTHFNQTKIRLSFNNIFDNHNITGDSFATKATPLLITANGNTYNNPFVSASPITPLSGADAVSILPGRSVMLSVTFGLSPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B4</accession>
    <name>E8X4B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1178</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579564.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1178"/>
    <dbReference type="EnsemblBacteria" id="ADW68241">
        <property type="protein sequence ID" value="ADW68241"/>
        <property type="gene ID" value="AciX9_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1178"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="ICPGIIE"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="26068" checksum="2115B8694709E9D9" modified="2011-04-05" version="1">MPELTGKVALITGASRGIGKATAIALAAAGAHVLIHYGRSASEAEALVAEIRQSGAKADALQADLSAPDGPASLAEQVRAKLTTPLDILVLNAGISKAAKIEDHTIADFDNLFATNVRGPFFVLQQLLPQLTAGSSVIAITSIVAHAIPGNSGQPGAPALPVYASTKGALETLVKHWASILGPSGIRVNSVAPGVIETDMSNFTKTEGGRNLALGMQALKRIGQPSDVADVVTFIASDGARWITGATIPVDGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C6</accession>
    <name>E8X4C6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1190</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1190"/>
    <dbReference type="EnsemblBacteria" id="ADW68253">
        <property type="protein sequence ID" value="ADW68253"/>
        <property type="gene ID" value="AciX9_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1190"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237255_0_0_0"/>
    <dbReference type="OMA" id="TVAMGMN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234365" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1546"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="598"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="695"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="794"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="891"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="1371"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1631" mass="161253" checksum="07AE52928ED2F291" modified="2011-04-05" version="1">MSFMKKASHYFLLALVLCAGLVVSPAQAQQVLQFPGLTPVGTTAGSQAVTVNFSAAGSISSIKVRTQGVDGYDYTNAGGGTCSTSMSYSAGQTCTVLVGFTPKAPGERRGAVVLVNSNGGVLGTALMDGFASGAVGVFIPGEITTVAGSSVWIYNGEGVATQSPFFLPFGVTLDAAGNLYITDTSNTRIRKVDAVTGMTSTIAGNGTIGGTGDGGPATSATLSSPSSVALDGAGNVFISDTGNNVIRKVNVFDGTISTIAGQMGKNGYVGDGGPASSAKLNGPNGLVFDAQGNLYFCDTNNNVVRRIDAGTGVITTFAGNGVTTGGYGDGGPAAAAMLNAPWGIAVSSKGEIYIADQGNSLIRKVVNGTISTVAGTHDAADTGSNPPAIHTQLNSPAGVVVDVAGNLYISDSGNNLIRKVNTNTGVISTIGGGTAQSTTQNTNDNGPATQGSVYGPYTLALDAQGSLYISDVFENRIRKISSNLAVLKFPTQRVGRVSAPLPQILENDGNADLNISTVLGVQQAKVDAGSTTCVMGTPLAALSQCVIGAEFAPTQVGTVIAGTLDASSDASNSPAEISLQGQVLDVDPSTVTLTSNTNPSLAGQVITFVATATSVGTTPTGEMDLMDGTTQVATGTLQPGGTISFNVSTLAVGTHAMTAVYSGDSSNSNGTSAVVSQIVKPVVAPTATSLGSNINPLNAGATVQFTATVTVVTAGSGTGEITGSVVFSDGVNQLGSSNIVNGMATLNVSTLSVGTHNVIATYSGSTSYSTSKSVAVVEIVQTATSKTALSTASNPSTAGAALTLTATILTTGGTATGPVSFLDGTTVLGSATLNKQGVATLVVPGSAWTVGTHPLTANYGGDSFDTGSISPGVSQIVNVASTSSVVTSSLNPVGLGGSVTFTATVTSNGGGQATGTVQFMDGTALLGSGTLNAAGATTFTTSTLALGSHPITVVYGGDAYDSGSSSVSMTEVVQSATINIAFATSGNPVTFGTALVLNAKVAGSGSQPVGTVIFTDGGLSIGTATLDANGAATITTSTLAIGSHPLVAVYGGDTNHASVTSTGITESVMQVTTTALSASTQSQIAGLPVQWTINVVGANAKALTGSVTISDNGTLVTTLPLDATGAASYSSSSLTPGQHSMVAKYSGDANDQVSASTPAVTTINTATTTTTFTTNANPVFTGTPIVFTAVVTGNGGTPTGSVQFLDGTTVLQTVPVVTANGATTASMTLSTLAAGIHKLSASYTGDTLDHSSVSSTINEQIAQKTSITIASSANPSLLTDDVSFTVTVSNGVTGSVPTGTVTLTDGGTAVGSLALNGSGVATFTLQAPALGAHTLVASYAGDNSNSPATTAPLVQTVVLRPSTNTFSTSTTALSAGQSVTLISVVQGVGPKAPTGSVTFAAGGIVLGTAPINATGVATLSVTPIQATYKIVSTYSGDSLYAPSDSAAITVVVGPTIEFTINMTPSSMTIKSGDHGTLQIAITTASTFTDTLALGCAGLPTAATCTFSQNEIKVSNGLATTVTVIVDTGNPLGAGANVTAKNEHGGFGGNGVLACMLPAGLLAMFFGRKRIRRPLGLLVMMLLLGSVAGLSGCANSFSMTDTPAGSYTFQIVGSGNATGATQAGTVKLTVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E7</accession>
    <name>E8X4E7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1211</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579597.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1211"/>
    <dbReference type="EnsemblBacteria" id="ADW68274">
        <property type="protein sequence ID" value="ADW68274"/>
        <property type="gene ID" value="AciX9_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1211"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_3_0"/>
    <dbReference type="OMA" id="PCPDLHH"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233662" evidence="6">
        <location>
            <begin position="25"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="478" mass="51634" checksum="65A738759B920C60" modified="2011-04-05" version="1">MKIRLVRPGFGLSVLMLASSAAFAGTVKVNDFGAKGDGSTMDTAAIQKAIDAAAKSHGTVVFAPGTYLSGSIFVKSGVTLQLDKGVTILGSQRIEDYPVMPTRVAGIEMSWPAALVNVYEQKDAVITGEGTIDGDGKIYWDSYWTLRKGYEPRGLRWASDYDARRPRLVQVFNSSHIKIGGGLLLRRSGFWTLHICYSTDVTADGLTIRNNEGGRGPSTDGIDIDSSKHIVVAHADIAVNDDALCLKAGRDSDGLRVNRPTEDVVLRDSTIRDGAAGVTFGSETSGGFRNIEAYNLKVFGHVPVGILFKSAHTRGGFAENVRIHDLTLTDIPVVLKVTMNWNPSYSYATIPATETNYPAYWKVLSTPVPDAQGIAHVHDVHIWNIAATGAKSAFEVEAYKQAPLERFQLDHLKIDALTAGHIADAKDWTFSDVSLTTKDGSTVELLDSTDVTGIPTYPGSEKPKTDAPAKSFKEQDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F9</accession>
    <name>E8X4F9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TOBE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1223</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579609.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1223"/>
    <dbReference type="EnsemblBacteria" id="ADW68286">
        <property type="protein sequence ID" value="ADW68286"/>
        <property type="gene ID" value="AciX9_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1223"/>
    <dbReference type="eggNOG" id="COG3585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118993_1_3_0"/>
    <dbReference type="OMA" id="KMSIRNQ"/>
    <dbReference type="OrthoDB" id="2019258at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7273" checksum="696A9E2EF4C9036A" modified="2011-04-05" version="1">MKISARNQLKGTVESVVLGVVTAKVSVRVGDNLIESVITRQSVEDLNIQVGSTVTAVIKSTEIMLMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J4</accession>
    <name>E8X4J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2367</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2367"/>
    <dbReference type="EnsemblBacteria" id="ADW69404">
        <property type="protein sequence ID" value="ADW69404"/>
        <property type="gene ID" value="AciX9_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2367"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_0"/>
    <dbReference type="OMA" id="KGRFFTW"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="19869" checksum="D003706CA3411D35" modified="2011-04-05" version="1">MPPPSLLDDAALLSQVQRGDEAAMASLFDRYSKVVYSVALRVLRDPAAAEDVLQEIFMQIWRTPDGFIATRGSLGGWLAVVSRNRSIDALRRKRPSEQVDDLGLASSYDLADEAERNSLIEKARGVIHLLPPEQRKTIEMAFFDGLTHSEIAEMTGDPLGTVKTRIRSALQTLRKAFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N3</accession>
    <name>E8X4N3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580759.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2406"/>
    <dbReference type="EnsemblBacteria" id="ADW69443">
        <property type="protein sequence ID" value="ADW69443"/>
        <property type="gene ID" value="AciX9_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2406"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_4_1_0"/>
    <dbReference type="OMA" id="MQILIYV"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18327" checksum="89ED5183B3BEF2BA" modified="2011-04-05" version="1">MQLALFIIFAALAIAGALNLLLQRHPINSALSLVVVMMSLAVLYWTLGAEFLAAAQVIVYAGAIMVLFVFVVMLLNAGEEERTTGSRAAYLAGVPGATAVFCLLSFVFLTESKAIGNATLGGMLSGGVNNIAEISQVLFTRLLLPFEVTSVLILVAILGAVVLARKTEPEEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P1</accession>
    <name>E8X4P1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">AciX9_2414</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580767.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2414"/>
    <dbReference type="EnsemblBacteria" id="ADW69451">
        <property type="protein sequence ID" value="ADW69451"/>
        <property type="gene ID" value="AciX9_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2414"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_2_0"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26958" checksum="7A05B2EB8BF8B59B" modified="2011-04-05" version="1">MPTQLLFTRFLNAHFAGPVDALLRAMHVQPLYPRAPISNAFSMELLIFIAMILYFVAVRATLSVEKPGAVQHLAEMTHEFVSEQGESIIGHGFETFTGYLTVLGLFILIGNLMGLVPGLESPTADVVVPLGFALVTFFYYHYYGIKSNGFGYIKQFLGPVWQLSWLLLPIEVISHLARVLSLTVRLYANMFAGDLVTLAFFSLVPVGIPLVFMFLHLGVAVVQAYVFMLLAMIYLSLATAHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S3</accession>
    <name>E8X4S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3558"/>
    <dbReference type="EnsemblBacteria" id="ADW70562">
        <property type="protein sequence ID" value="ADW70562"/>
        <property type="gene ID" value="AciX9_3558"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3558"/>
    <dbReference type="HOGENOM" id="CLU_3344194_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="37" mass="4204" checksum="24B816AFB19C840C" modified="2011-04-05" version="1">MSSAGHTESWLDRFWPLLVILVGVLFLTLILTFQPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X6</accession>
    <name>E8X4X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caa(3)-type oxidase, subunit IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0077</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578497.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0077"/>
    <dbReference type="EnsemblBacteria" id="ADW67168">
        <property type="protein sequence ID" value="ADW67168"/>
        <property type="gene ID" value="AciX9_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0077"/>
    <dbReference type="eggNOG" id="ENOG50339NS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146734_0_0_0"/>
    <dbReference type="OMA" id="IAFFMHM"/>
    <dbReference type="OrthoDB" id="1893782at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011743">
        <property type="entry name" value="Caa3_sub_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02229">
        <property type="entry name" value="caa3_sub_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12363" checksum="A0233A724D8D4544" modified="2011-04-05" version="1">MSQANDASNVNNPEHVEHHIVSPLQYSYVFATLLLFTAITVGAAYVELGVFNPIVALGIASFKAVVVILFFMHVKYQSRLIKMTVGAGFFTFLVMITMTLSDYISRAWGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X532</accession>
    <name>E8X532_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0149</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578552.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0149"/>
    <dbReference type="EnsemblBacteria" id="ADW67224">
        <property type="protein sequence ID" value="ADW67224"/>
        <property type="gene ID" value="AciX9_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0149"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_0_0"/>
    <dbReference type="OMA" id="PHLDAFA"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="510" mass="56095" checksum="52DE186F875BC583" modified="2011-04-05" version="1">MSDNQLKSTRREFVAQAAVTALAGALGAGAEAQPHDSSRPNVLFLMSDDMRVELGCYGSRFRAQSPNLDALAKRGVRFDRNYCQFPLCNPSRSSLLTGQVPLETEVLGNRTNFRDTRPDLTSLPQLFKEQGYVTARSGKIFHDIYDDEKAWTVGGGNAVTQQPGHESAQLGHKLVIPREAVPSPPSGVVPPLPQDNQQAMHSDQIIVLDGDGEGHPENRVAEKAIEYLRTYRNQPFFIGCGFSKPHSPPTAPQRFFDLYDPAKLELTPDFAAWPTVPPGFPKAAIRMRNADLFIGRGASTHEAQEVIRAYLASISWADWNIGRVLAELDALGLRKNTIVVFVADHGYQLGEKGKWSKAGSLFEMGTRVPLIIHDPRAAGNGAASVRLVESLDLYPTLVELCGLKPPAGGLQGTSLTPLLRRPKAAWDKPAYSIWSEDGKTVHGVAVRHDRWRYAEFGEDGVNGRMLFDEQEDPLEMKNLAEHPDHAARCAKFATLARAYVRRQRAAASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X586</accession>
    <name>E8X586_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ordered locus">AciX9_1288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579673.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1288"/>
    <dbReference type="EnsemblBacteria" id="ADW68350">
        <property type="protein sequence ID" value="ADW68350"/>
        <property type="gene ID" value="AciX9_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1288"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_0_0"/>
    <dbReference type="OMA" id="IGKHLFE"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21288" checksum="900D26A8E0F87A21" modified="2011-04-05" version="1">MTATKPAQTTFTPAAVPATLQRIILTGFMGAGKTSVGRLLAEQLGWAFLDLDEHLETRANATIPELFARDGEARFRRIESSALANALSHTHTVIALGGGAPEQLTNRLLLEQTPNTHIIFLDAPFPVLFDRCMLQSFASPDHIRPLLASPEQAEARFLTRQPIYRRLARLTLSTADLTTQQAVDQLLSSLTTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B4</accession>
    <name>E8X5B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2425"/>
    <dbReference type="EnsemblBacteria" id="ADW69461">
        <property type="protein sequence ID" value="ADW69461"/>
        <property type="gene ID" value="AciX9_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2425"/>
    <dbReference type="eggNOG" id="ENOG502ZC6D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053479_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233698" evidence="1">
        <location>
            <begin position="25"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="38688" checksum="FB32471AF80F2448" modified="2011-04-05" version="1">MSRCSVVGPFVTLLSLSACTSLLAGCSSSGGTAIPPHIVATQHILFVGDSFTHGRYAPVRTYNSTPGTGGLGSTAASPLVVDENFNTTVTAREENSPGETGPWGGIPGIFAELAAEAAIPYDVHIEAISATSLNKNYQAAQSVIAQSVWNTVVLQEATFEPIPPSLSGDSISKPATFCSAVGTIEQGVHAAAPSASVYLYETGAPADTAYGNSTASSAFSDSAYLSALGTLTDAYHDAYLTAATQDGHIAGVAATGDAWSRAWSEGIANPDPYGGSAAGVSLTFNYQPGSQPSTTSKPTDAGFHHPSIYGAYLNGLVLFQKITGTDVRTFGGTEKAAQTLGISAAVAVQLQQIAWESVTMQNTQLVHPTVNACALTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C0</accession>
    <name>E8X5C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FkbH like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2431</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2431"/>
    <dbReference type="EnsemblBacteria" id="ADW69467">
        <property type="protein sequence ID" value="ADW69467"/>
        <property type="gene ID" value="AciX9_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2431"/>
    <dbReference type="eggNOG" id="COG3882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018095_1_1_0"/>
    <dbReference type="OrthoDB" id="1310135at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="606" mass="68228" checksum="007D5FDF44546F7C" modified="2011-04-05" version="1">MPDAYKIEGMIDLDFCSADELLLRRRSLRRELSAVDGLQELRIAVLGGSTTDQIVTTLEIFLLAAGFQPVFHQSEYGRYYDDAVYDPQTLIDFRPNLVYIHTSCRNVRNLPPLNCTESQLPGYVETELNRFKEIWDSLDARVGCQVIQNNFEMPPHAILGNMDAVAAGGENRFLMELNVAFAREATRRPRLLLQDVHGISAKVGLRNWFDWTLFFNFKLLLQPAANLELARSLNAMIQAIYGKSRKVLVLDLDNTLWGGTIGDDGVDKILIGRETPQAEAYTAFQEYCLSLRNRGILLAICSKNDEDIAKAGFSHPDSILKLEHISCFKANWEPKHENIALIAKELNLGVDSFVFVDDNPAERAIVQAQIPGVAVPDIGNDVTHYAEVIQAARYFEPASLSREDRERAALYASNLQRADQAATFNNYGEYLDSLDMSAEIDSFKPVYLERIAQLTNKTNQFNLTSRRYTLAEMEVAMRDRNTIALYGKLSDRFGDNGLISIVLGRRDGDTVHIDLWLMSCRVLKRSMETAMLDALAERALGMGVKVVRGNYLPTAKNSMVADHYSRLGFQPCPQPSLPEGATAWQLNLTGYVRKNSHIRVLEYTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F1</accession>
    <name>E8X5F1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2465</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580814.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2465"/>
    <dbReference type="EnsemblBacteria" id="ADW69498">
        <property type="protein sequence ID" value="ADW69498"/>
        <property type="gene ID" value="AciX9_2465"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2465"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_0"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="41404" checksum="EC43D018B488918D" modified="2011-04-05" version="1">MFGLTDEQESLRREVRSFAAKEVLPGREERDETSEFPHGIVKKLGEMGLMGVIFPEELGGSGLGYVEYVLAIEELSRVDGSVGIIVASHNSLCTNHLMLAGNEEQKKRWVTKLATGEWLGAWGLTEPGSGSDAGGMRTTAVRRGDEWVLNGGKTFITNGTYANCALVLAVTDKEKKTHGGISAFLVERGTKGFRAGKKENKLGLRASDTAELIFEDCVVPAENLVGVEGAGFKDAMRVLDGGRISIAALSLGIARGALDAAMKYATERRQFGKAISEFQAIQFKLATMATELDAAWLLTMRAARMKDAGENVTLESSMAKLYASEVACRICDEGVQIHGGYGFIKDYPAEKFYRDVKLCTIGEGTSEIQRMVIARELLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F3</accession>
    <name>E8X5F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_2467</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2467"/>
    <dbReference type="EnsemblBacteria" id="ADW69500">
        <property type="protein sequence ID" value="ADW69500"/>
        <property type="gene ID" value="AciX9_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2467"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133161_0_0_0"/>
    <dbReference type="OMA" id="LAANSWQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="25560" checksum="CDD6FADBD4A4B43F" modified="2011-04-05" version="1">MFPDRTLFDDSLFSSAPTQISKTKKWATTAAIAAQIAILALILIAPLLHPATLAMAMTGPTVILANPPRPIPKPIPVKPAEATHTSTTPSSPSPAQPAALLARSYGHIIPGIPPDEPSLAPIGSTNTMGTPTGIASGIPSISGGGATVVKAASPQKVRLSSGVTSGMLLTPIHPTYPPIARAAHQEGTVVLTATIDKTGKIVGLQVTSGPAMLRSSALEAVSAAHYKPYLLNGDPTEVETTISVIFHLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J8</accession>
    <name>E8X5J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_3622</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581936.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3622"/>
    <dbReference type="TCDB" id="2.C.1.1.7">
        <property type="family name" value="the tonb-exbb-exbd/tola-tolq-tolr outer membrane receptor energizers and stabilizers (tonb/tola) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70625">
        <property type="protein sequence ID" value="ADW70625"/>
        <property type="gene ID" value="AciX9_3622"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3622"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133161_0_0_0"/>
    <dbReference type="OMA" id="ARTQPYN"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="25590" checksum="209EAD5460073330" modified="2011-04-05" version="1">MFEDSLVDSGGRLKTKSKYWMIGTGILNLCIVAVLIVIPLIYPEALPHTAMTAMLSAPPPPPPPPPPPPPEVVVKQVKVVVTQIDDALHAPTKIPKKIDMSKEDAAPPPQVSTVVGMTGMSGGAAGGIPGGVMGGMGTAPPVVVKTPEKPKGPARISGGVIAGNIIEKTQPTYPPIAKAAHVSGAVVLHAIISKNGTIQNLTVISGPEMLRASALDAVKSWRYKPYILNGDPTEVDTTVTVNFSLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K3</accession>
    <name>E8X5K3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">AciX9_3627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70630">
        <property type="protein sequence ID" value="ADW70630"/>
        <property type="gene ID" value="AciX9_3627"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3627"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="9940" checksum="8780352FA46256DF" modified="2011-04-05" version="1">MTVISHPQNATEEMLHFTRLLIVALVEDPQAVEVSAISGTFSTTLRVTVAAADLGKVIGKQGRTARSLRILIAAAGIRLQQRFELDIRKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W4</accession>
    <name>E8X5W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4059</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572760.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70848">
        <property type="protein sequence ID" value="ADW70848"/>
        <property type="gene ID" value="AciX9_4059"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4059"/>
    <dbReference type="HOGENOM" id="CLU_003690_2_1_0"/>
    <dbReference type="OMA" id="WIREIMN"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230267" evidence="1">
        <location>
            <begin position="20"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="259"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="743" mass="82409" checksum="3C04730D253780DD" modified="2011-04-05" version="1">MRKSLLLFVIAASPMFAQRDAVSYVNPLIGTEKSALGYGGTMPFVTPPFGMTNWTPQTRQNKISVTSYNYDDATVSGFIGTHQPAIWMGDYGYVTVVPQVGPLRIAANERAMPMRHENEKAQPDRYSVILSAGDHGNLRAELTATTRCAMFRFTFPSDITARVLVEASRPGVAGGAFLSPRAGEISGYNADRMDSHLGPMKLPNFKGYFVVQFETAPLKTETYGMEQTGDQASRGAYAEFAPGSSLLMRVGTSFLSVDQARENIRREIPGWDFETAAQRLRAAWNEKLSAIQVEGATDAEKSRLYTALYHALLYPRTFSEYGRYYSAFDDQIHTGESYTAFSIWDTFRAENSLLTLLVPERIDGMITALLQDFREGGWMPKWPNPSYTNIMIATHADSLVAEAFRKGFHGFDRELAWNAVYKDAMTPPDGDTARRWLDREEHTPYEARAGLTYYKQLGFIPTDTTDESASNTLEDSYDDWCVAQVARLTGREEDYQFFLHRSLNNRSLYNPAIGLMNGRKSDGTWAPLGSSEDTLENRSRAGWTEGDAWAYTWSALHDQAGLLALMGGAAAYDSKLDQHFSGGHNVHRNEPSHHYGYLYDFGGQPWKTQAMVRSIAAKEYAAGPGGLDGDDDCGQMSAWLLFTALGFYPVNPASGDYMIGSPLYARITLRLANGKQLQVEAENNSATNVYIQSATLNAKPLTVPLITWEQIQAGASLHFVMGPRPSTWASAWRAAPIVAKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y1</accession>
    <name>E8X5Y1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_4082</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
            <plasmid evidence="12">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70865">
        <property type="protein sequence ID" value="ADW70865"/>
        <property type="gene ID" value="AciX9_4082"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4082"/>
    <dbReference type="HOGENOM" id="CLU_590123_0_0_0"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="468" mass="50001" checksum="29C45C57C949D2A7" modified="2011-04-05" version="1">MGLMAASVCVAQQPGEGAGEVAAKSAWLTLTAGQKGEVMQFAEPYKDYLRHAKSAMLSEAELERLARGAGFAEYISAAQVKPGARLIIKNRGRAALFVVVGTDPIESGSRMVGSHEDSPHINLKSRPVIDAPGSMALLKTMPYGGIKRYQWANLPMALVGHIDTVDGRHIEVSIGFGAGEPVFVIADAAPHSDSQLRSRTYTTVFGGEEMNPVIGSIPGEKSTVAAEVMTALRARYKIHDEDLVSSELELVPATQPADVGIDGGLTGSWGQDDKLSAYTSVRALLDVKGTPKKTAMAYVTNFEETGSVNNTGAGSDFLDMAFTTLLDAQGKPATALGVRTAMRNAAVLSADCNDGVNPIFPGNSENSNSAVLGYGVTVKKYGAGFDPNSEFEARVLRVLDENHIAWQTQTPKVDVGGGGTIGGFLSRRNMEVLDIGIPLLSMHSTYEMSSKVDLWSYYRFMKAFYTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y7</accession>
    <name>E8X5Y7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4091</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572783.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70871">
        <property type="protein sequence ID" value="ADW70871"/>
        <property type="gene ID" value="AciX9_4091"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4091"/>
    <dbReference type="HOGENOM" id="CLU_1243868_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="25342" checksum="7606C5209D99C30D" modified="2011-04-05" version="1">MSPDKSSALGAEQAQPKAPPIARRVWSLDRAALASLLLVLDGDPDQAAVAYEALRQRLIRFFHLHQVSDTDGFTDICLDRLARRIHQGLVVESPLSYAVGIARMLLREERTAQRRRETMIEDFSRLGPGHLTEEVMIQGISLPNLEQYLEHCLQHLAPVQRKQILLYYSATAREGIDIRQQMAAESDLSLNTFRNRMLRLRKLLEDCLRKRIAAQDLKRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X612</accession>
    <name>E8X612_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4116</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572808.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70896">
        <property type="protein sequence ID" value="ADW70896"/>
        <property type="gene ID" value="AciX9_4116"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4116"/>
    <dbReference type="HOGENOM" id="CLU_015182_6_1_0"/>
    <dbReference type="OrthoDB" id="883503at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="210"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="45133" checksum="AA6E8F6AFBC8D941" modified="2011-04-05" version="1">MSTTSSTLNSVLSALGGSNGIDVTSTVASILYADRAPERAWQAQQTTLATQTAAIQQIESESSSLSDALSALQSSTGALTSAAATSSNSDVVTATAVAGTPVSSHLIVVNSLAATGSWYSDPPTSSTATLTAGSFDITIGGATKTISVSSSDTLATVAASINSQSLGVTANVVTDSTGSRLALVSTTSGTAGDFSIGNDSTTTFKRANTGTDASLTVDGVPISSSSNTVEGALSGVTLNLVGAAPNSEISLNVAPDTSSITDAVNTFVTAYNTLITDVNSQFKYDSSTATAGTLQSDSAVQGLQSALLAATNYSSGSATLSNLNALGISTNADGTLTLNSTLLGVAVQSNSAAVTNFFQGSALDGFAASLTSTLNTYTDPTQGAFTVDLKSISNEYSDLSDQTSTLELYLASQQIILTAQYNAADIAIQQLPQKLKQIQALLNPNASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X617</accession>
    <name>E8X617_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma-28 factor FlgM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572813.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70901">
        <property type="protein sequence ID" value="ADW70901"/>
        <property type="gene ID" value="AciX9_4121"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4121"/>
    <dbReference type="HOGENOM" id="CLU_2316356_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlgM" evidence="2">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="10359" checksum="05101E12D74978A3" modified="2011-04-05" version="1">MRVDLYNSAAATEATTQASKIAQDKSLNAQAKTGVQKTETEDTTTLTSASDPVQSLTKTALETTPSRAAKVALLKQSVNDATYQLDSAKIAEALANADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X656</accession>
    <name>E8X656_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ordered locus">AciX9_4160</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572852.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70940">
        <property type="protein sequence ID" value="ADW70940"/>
        <property type="gene ID" value="AciX9_4160"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4160"/>
    <dbReference type="HOGENOM" id="CLU_088964_0_0_0"/>
    <dbReference type="OMA" id="REGWDHS"/>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="21997" checksum="DC7B9CECFACAF2C7" modified="2011-04-05" version="1">MAILLNIQSSPRGADSLSRILSQEFVSEWKQNHGDGTVVLRDLAETQLPFISAPWIGGIFLPAEQRSTAQQDAIKVSDELIAELFAADHILIGTPMYNFTVPANLKAWIDMVVRPKVTHSGPPERRGLVTGKRCTIIIASGGVYDEGLPAAASDYESGYLKRILGFIGITEVEVVMAGGTAAAAFGATTMEELAGQFRPAVLAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X663</accession>
    <name>E8X663_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4167</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572859.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70947">
        <property type="protein sequence ID" value="ADW70947"/>
        <property type="gene ID" value="AciX9_4167"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4167"/>
    <dbReference type="HOGENOM" id="CLU_082324_2_0_0"/>
    <dbReference type="OMA" id="AYYRPWV"/>
    <dbReference type="OrthoDB" id="1369887at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011392">
        <property type="entry name" value="Tellurite-R_TerY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020634">
        <property type="entry name" value="TerY_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23122" checksum="3A7585E1F0153A2D" modified="2011-04-05" version="1">MLNLEFATNPDPRCACIFLLDTSGSMKGAPIDALNEGLRSFEHDIQDDALARRRVEIAIITFGGITRQIQPWVSAGAFQAPVLTTGGGTPMGEAMYEGVRMINIRKAEYKAAGLSYYQPWVFLITDGTPTDEWLQAAAVVRRETAARGLTFFAVGVGDADMDTLKAITDRVLKLDGLSFRELFLWVSASQKGISRSKADEQTALPAVTFGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X672</accession>
    <name>E8X672_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M61 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572868.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70956">
        <property type="protein sequence ID" value="ADW70956"/>
        <property type="gene ID" value="AciX9_4177"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4177"/>
    <dbReference type="HOGENOM" id="CLU_435415_0_0_0"/>
    <dbReference type="OrthoDB" id="679125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024191">
        <property type="entry name" value="Peptidase_M61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016493">
        <property type="entry name" value="Glycyl_aminpptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234228" evidence="1">
        <location>
            <begin position="21"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="517"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="647" mass="69475" checksum="7E319288967A5601" modified="2011-04-05" version="1">MPIRPSLFLSAVLCSAAAFAQSAPIKIVADLSEAPRRLYHAEIDIPVKSGPLTLTTPKWIPGNHRPTGPVDDITGVVFTANGETLKWRRDDVDLYEFHLTVPKGVTNVHAHLDFIVEGRVTDHMAVLEWEKLLLYPADKPGREIAIQPSITVPAGWGIGTALQPTGAGTNAVNTGIGAKDHGPTAGATTTNYAATTVEQLEDSPAIAGQYFHEFPLAPEMGVKHYIDVVSDLPEDSNLRPDLLAETANLVREANAAYGSHHYNTYHFLLTLSDVAGGEGLEHGQSSDNGVGEKAFSTAHPGSDLLAHEYTHSWNGKYRRPARLYQEKFSTAEQGDLLWVYEGMTQYMGNVLAVRSGLKTKQQYLDTIATTAAGLDTKAGRQWRSTEDTAIAASILRGGSPAWSNWKRGQDYYQEGALLWLDADTKIRQLTQGKKSLTDFQQIFLAKGGSTGPMIAPYERPELIADLNTIAPYDWATFLRDRVDAITPRADVAGIEQGGYKLVYLDHPPKREAGEGPQRGGGGPDVWYSLGIRIGGGGPAGRGGGGEGTISDVRWGGPGDDAGLYPGQKIVAVNGTAFSAEALIAAVKGAKGTSEPIHFLVEHEGAVKTVDLSYHDGERYPSLERVDGTPDFLGDIAKPLAAPVTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A8</accession>
    <name>E8X6A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ASPIC/UnbV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4214</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70992">
        <property type="protein sequence ID" value="ADW70992"/>
        <property type="gene ID" value="AciX9_4214"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4214"/>
    <dbReference type="HOGENOM" id="CLU_017657_0_0_0"/>
    <dbReference type="OMA" id="FFVANYG"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234437" evidence="3">
        <location>
            <begin position="38"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="UnbV_ASPIC" evidence="4">
        <location>
            <begin position="550"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="636" mass="68105" checksum="F97C19FEED8FC214" modified="2011-04-05" version="1">MADAEPAFVQPVTMAMSSARSLRLSLALLAVCSPLLAQTPLESQKQSAQEGAQAPGHGGSGTAGIFPPVLDSAKRPITAGGTVKTGPIVFADIAQKAGLTSWHHTMGSPEKRYIIDTLGSGVALLDYDNDGWLDIYLVNGSTAPALAGKQPSPHAALFHNNHDGTFTDVTAKAGVANDRWGIGVAVGDYDNDGWPDLYVTNFGGNRLFHNNHDGTFTDVAVKAGVALGNWSTGATWGDYDGDGKLDLFVPGYVHYDLKNQSGDATVPLTFCQYRGVKTMCGPRGLPGESDHLFHNNGDGTFTDVSEKAGVSDKSGYYGLASVFIDVNNDGRADLLVANDSTPNYLYLNQGNGTFEDVSYASGYALNKDGRETASMGIAVADYRNNGLIDIYNTTFSDDYKPLYRNDGDANFTDISYETHISELTIPFLGWGTAFLDYDNDGWRDLLEVNGHVYRNADTNNWGTTWAQRPLLFHNVAGKSFDTVPAVEGTGLAAAMTSRGLAVGDLFNDGRTDAVINNLDAAPALLRNVDNDKHHWVAFRLTGGPKSPRDAIGATLYLTANGMRQRADIFSGGSFASTSDMRPHFGLGSATTVEKLEVHWPSGLREQFAVPTIDQFQSITEGKGTEIAKPTTVPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F1</accession>
    <name>E8X6F1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4259</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572947.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71035">
        <property type="protein sequence ID" value="ADW71035"/>
        <property type="gene ID" value="AciX9_4259"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4259"/>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_0"/>
    <dbReference type="OMA" id="PFRAMNL"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5110" evidence="3">
        <location>
            <begin position="661"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="740" mass="82381" checksum="A102FA7BE0C16648" modified="2011-04-05" version="1">MSNDLSRRAAIARIGTASAALLLTRRFAAAELFSALSEKIPSAPVGMDLTITAVTPHTLRINIAAVDESLDRYYEDGALAPRNFGAPLATLRTDSVGQEIPFGDYRLTIATKPLRITATNAAGKQIQELTFRPDLNQIGFLYNDAPIYGMGTGVHPMDRRGGKDMMRNGSGDNLRIFGARNPIPWLMGKGFGLFFHEPGGQFDLSGDTGFFKPSDVARGQDLFLVLAETPAELLRQYAEITGYPHLPARWTFGFQQSHRTIDTRAQIIDEAKTFREKKLPCDTVIYLGTGFCPSGWNTGHGSFVFNQALFPDPAQVIKEFHDLHMNVVLHVVNPPENLHGHVTDTGTAASFPANAANYWKQHVPFIEEGVDGWWPDEGDVLPQASRLVRNRMYWEGGRMTRPDRRPFALHRNCYAGIQRWGWLWSGDTFSTWKTLETQIMIGIGCGLSGVPYWGTDIGGFVPTKEFTAELFVRWFQFGAFCPSFRCHGRTWQLRRPWGWDTGTYGASEMGTNAEAFLPKGDELHNKAVEPICRAFLNTRYQLMPYLYSAAYETHTTGLPLIRSLGLAFPNDAQSWSTVDAYLYGPSLLVAPVFERGATSRKVYLPAGPWYDYWTGKRTEGGTTITVATPLESMPLFVRAGAILPTGPIKQYTAEPSTEPTHLTIYPGADGRFTLYDDDGLTFEYEKGRSTKVELTWTESTRTLQLTADNIDFQHYGFIVSLVGGEKKTVAAHRGTQTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J4</accession>
    <name>E8X6J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3861</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582165.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71144">
        <property type="protein sequence ID" value="ADW71144"/>
        <property type="gene ID" value="AciX9_3861"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3861"/>
    <dbReference type="HOGENOM" id="CLU_011447_2_1_0"/>
    <dbReference type="OMA" id="ISANTPY"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010425">
        <property type="entry name" value="Caps_synth_GfcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06251">
        <property type="entry name" value="Caps_synth_GfcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230799" evidence="3">
        <location>
            <begin position="27"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="5">
        <location>
            <begin position="232"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="5">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Caps_synth_GfcC" evidence="4">
        <location>
            <begin position="696"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="932" mass="100563" checksum="CEE63F833EC1ED76" modified="2011-04-05" version="1">MFRLTSRRLSLNIFRIVALASLPVAAFSQTSTSADCSTTLLSGTGPCSSQATGVDITNGSLINSTGVPYATSGQQRPPDNAPVYVDSAGYRQIRQGNDGTDRNQTFFPPDPVSDFQKLTRSSTGEILPLFGRDLFQRAPSTFAPADQIPVTADYIVGPGDEVLLHLWGAEQVNGNSQLTVDTSGNIYVPRVGAIHVAGLRMDQLQGQISAEINHIYRNYRIAVSLGHLRSIQIYVVGEARRPGTYTISSLSTVLNALFASGGPTLAGSMRHIQIRRGSQTVGELDLYDLVLKGDKSHDVRLESGDTIFIPVVGPQVAVAGSVRHPAVFELKDDTSAANSLQDLLTLAGGFSATASTRQIRLERVDTDGQRHAMTVQLDVAARAMPLHDGDVLYANHIDSGFESSITVRGNLANPGRFAWKPGMHLSDILPDRAALLTGDFWRERNRMGVPTPLFEPYEYRDRPPVAGGADIDSTLYRSPQRPTGPPSARDALTSVQPPAIDNQDSSQAALASSGVTSSSTLSLDQEATNAASSANNLSSGAVANGSRTAMLFDQQQAQQQPQQQGAQGSQSGQNQSGQSQYGQGISEAMGLSPAAQQRLKPSIVLATKDVNTIRIPAPEIDWSYAVIERLNPNTLKTSLIPFNLGKLVAGHDPAQNLELQPGDVVTILNQRDVLVPQSEQTKYVRLEGEFVGAGVYSVEPNETLEHLIQRAGGFTSDAYLYGSSFLRESARAMQQQRLDEYITQLSTDLDRQTAITGASSTNGLSDPNALTLERNLVAQLRTLRATGRVVLEFKPDSAGLSGVPQIPLQNGDVFRVPSRPNTINVIGAVYAQNVFLYNPKRHLNDYMTLAGRPNRVADKDHAFIIRADGSVFSREHAKSILSNRFDEATIYPGDSIVVPEKLIKPTLTRQLLDYSQILSGFGLAAAAIEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M8</accession>
    <name>E8X6M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3902</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71178">
        <property type="protein sequence ID" value="ADW71178"/>
        <property type="gene ID" value="AciX9_3902"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3902"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_0"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="42676" checksum="5844E206EF7324A8" modified="2011-04-05" version="1">MSDRPAFQPSTLVIHSNRVYESQSNSILFPIHQTATYIHESVGVTKGYGYSRGANPTVNALEQSIAAIEGSESALCFRSGMAAITTLCLAMLKAGDHVLLSEVIYGGTTRLFEQVLGNFAIDYTFVDTANLKAVEQAIRPETRLIFAETPANPTLRLSDVHGLAELAHTRPNIKLAVDNTFLTPLLQNCLSLGADISMLSTTKYIDGHNATIGGSLATHDVALTERLRLVRKTLGTIQAPFDAWLTIQGIKTLPARLAMHCAHAGQVAQWLERHPRVLRVNYPGLESFPQRELAKKQQSGFGGMLSFELKATTSESLHFMKALKLCTCAESLGSVETLITNPATASHCDLTVELRARLGISDQLIRLSVGLEAPQDLIADFEQAFEAIFGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T3</accession>
    <name>E8X6T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71233">
        <property type="protein sequence ID" value="ADW71233"/>
        <property type="gene ID" value="AciX9_3957"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3957"/>
    <dbReference type="HOGENOM" id="CLU_052026_1_0_0"/>
    <dbReference type="OMA" id="HVTFVKY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="241"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="440" mass="48578" checksum="C4EBC1EED122147B" modified="2011-04-05" version="1">MAQRSDLTDNTNSRTTVLLMAYECSPAGGSELSVGWNRVMQAAREFEVHVITSPKSFEALTMARQSGLLPDHVHFYTPQPDWLLPLLQKLPVLFVYNYLAYQHFQRLAFNLAQQLHGQHGFAAVHQVNGTGFREPGYTWKMDIPFIWGPTGGTQNFPAAFLSYLPWREALKESLRTIVNQISLRFKPRVHQAAARASVVFAANSTNQRDFEESFGRPIELLLETGLPRLAAATSMSKYDGETPLRILWVGELATRKALPLLLRALASVKDELAFELQVLGKGPQEQSWKELAASLGIERHCTFSGHLALADAIAQQDWAHVFVFTSLRDTSGNVMLEALGAGVPVVCFDHQGAGDIVTSECGVKIAVVDPETAVHDFAAVLMELAGDRKRLRQLSHGARRRAIGYEWTANGDRMNRLYRELAAGEAEACAVPAEVGGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y2</accession>
    <name>E8X6Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Berberine/berberine domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3805</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582113.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71091">
        <property type="protein sequence ID" value="ADW71091"/>
        <property type="gene ID" value="AciX9_3805"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3805"/>
    <dbReference type="HOGENOM" id="CLU_018354_2_0_0"/>
    <dbReference type="OMA" id="CIVMAKK"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="53419" checksum="5C956EE71E9AB289" modified="2011-04-05" version="1">MPTTVTRQDPRFPIMRHGNNLRFPTHEEDYAGRIAYCDSPEDAAIALQKVLDAGLRPTVRSSGHCYEDFVVNNPNGAILDVSLLNRVSTGPGGAAPYRIQPGAMLGVIYQELYKRSNVTIPGGTCFTVTAGGHVSGGGYGLLARLHGLSTDWVSAVDILTVNAAGKVTPIQADATHNTDLFRALRGGGGGSFGLITGFTFNQLPPAPSQVIETGMSFDAATMTPEKYAKILATFGDYWQQHDQVKETWGLFGMMYFHGKGSNAAISINTQFTNPDGTVTDLTVLKDFLARFDAFQPTTRQPDLRPRLWIEATVNGGGGPLSIGGGGRAKYKSAYMKKSFTEAEALAFYNALQQESSRGIIIAVDCYGGAVNNPARARDTAIPQRTSLMKLQYQTYWNDPADDAARLKGIRDVYTAAYSTDLVDPAHKGTPYPGDHYDGCYMNYPDADMLDHPFWTDLYYGTGDTHPFLRKVKNTYDPHNVFHHAMSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X758</accession>
    <name>E8X758_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4340</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573011.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71292">
        <property type="protein sequence ID" value="ADW71292"/>
        <property type="gene ID" value="AciX9_4340"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4340"/>
    <dbReference type="HOGENOM" id="CLU_056689_1_0_0"/>
    <dbReference type="OMA" id="IEQFAYQ"/>
    <dbReference type="OrthoDB" id="1564715at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="29362" checksum="0672D04D56CD0E0E" modified="2011-04-05" version="1">MSVILTDPTPDTLSTQSAKLVENRSSVLTSRRCVLSTLAVAGAATAFSGSLAGCSSDGSVPLASSTPSVLDVLNFALNLEYLEASFYLYVTTGTGLSTADMGTGAGSVTGGAKVSFVNPIVAAVANQLATHERQHVEFLRSTITAVGGTPVPMPSINLAAGGAVTSDATFLAASRQLEAVGVSAYIGGAQYLTSSTAALTYAAQILDTESQHAGFIRELCIALGVTSPAVDSLDQPPTATQIFNTSNTTGLTPVRTTSQVLQIVYAAAGQTGVSKGGFFPNGLNGTIITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X761</accession>
    <name>E8X761_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4343</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573014.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71295">
        <property type="protein sequence ID" value="ADW71295"/>
        <property type="gene ID" value="AciX9_4343"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4343"/>
    <dbReference type="HOGENOM" id="CLU_057301_0_0_0"/>
    <dbReference type="OMA" id="HCQYCYL"/>
    <dbReference type="OrthoDB" id="1341636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="364" mass="40990" checksum="CFE80449EFA30615" modified="2011-04-05" version="1">MEKELQEAGVVQGKLWHPRRVLITPEALKLAHGQAMLSRAEQLGAEVIKLKANRLTGFTAEDERSAYAHAKTSFAIVISPPGQRRLQPIPPSADWQFHIAQGCPAHCQYCYLAGSLSGPPVTRAYANLPEILEGLYEYLGKGTITSKSRERAEEGTTFEASCYTDPLGIEHLTGALAESIRFFGAWEAPVQLRWTTKFDAVDHLMKLDHHRRTRVRFSLNAASISRDFEGGTAKLSQRLRALRKMALAGYPVGLTIAPIMPVENWRGEYSTLISDIAQSLVGVPNIDLTVELITHRFTPTSKDVLIGWYPKKTLDLREEVRTQKRTKFGGFKYVYPKDSMAEMQQFFRELLTQRLPGSKILYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X782</accession>
    <name>E8X782_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573035.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71316">
        <property type="protein sequence ID" value="ADW71316"/>
        <property type="gene ID" value="AciX9_4364"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4364"/>
    <dbReference type="HOGENOM" id="CLU_077340_0_0_0"/>
    <dbReference type="OMA" id="RRVCECY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="27836" checksum="BA89553B1FF9A210" modified="2011-04-05" version="1">MAQAPFKNGLLHRFSSDIIGRLDLQAVDLPVNCEIEFPGNPIEHLFFLEDGCASMTTTFKDGAQAEVALAGTEAVLGASALMGTKRSLNRVYMQIAGHGYKMRTAVAAMEFKRGGMFQDLTLRYLQAQFIQSAQTAGCNAHHSVEQRLARWLLLCADRNEGRTIPLSQEFMADMIGARRTTVTIVAGHLQAQKLIQYTRGKIQLLDIKGLEAVACECYGVVRDHLANLTEYDAGLGDVAVRPESGSLRLIHLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B2</accession>
    <name>E8X7B2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein RecA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4395</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573065.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71346">
        <property type="protein sequence ID" value="ADW71346"/>
        <property type="gene ID" value="AciX9_4395"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4395"/>
    <dbReference type="HOGENOM" id="CLU_056547_0_0_0"/>
    <dbReference type="OMA" id="LTQHPCA"/>
    <dbReference type="OrthoDB" id="1984634at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="39707" checksum="D0925155DA1C2F5E" modified="2011-04-05" version="1">MGYSSQSAMLKREIEAKLSSRIPAALSPQALQAPRLMSSGVLAIDGLLGGGLPIGGVTEFTGLASSGRTSLAFSLLRGATADSACAYIDVDDTFDPKCAAASGVNHQNLLWVRVASLRPRAEVEPSSPAPTSRIGQAEAGKMVGGHCGSNHPRTETKGLDAALGQMLMQKAETRLQKMEGTPGYPNGKLSLAAAPEEQVAYEHFNARHADESDPIRQADRRAATEARDRAQAPVLVTSAGKKIEKPWSRLDKAIRATDQILQSGGFRVVVLDLASVPPEQALRIPSATWFRFRRAAQESDAIFLLLTQVACARSSALCVLDCSAGAPMLSGNLLNGLSRTAEVARQRLSSPFAKKAPGRAVSWQAAPAWMRAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E1</accession>
    <name>E8X7E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4427</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573094.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71375">
        <property type="protein sequence ID" value="ADW71375"/>
        <property type="gene ID" value="AciX9_4427"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4427"/>
    <dbReference type="HOGENOM" id="CLU_638991_0_0_0"/>
    <dbReference type="OMA" id="WYSINTH"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="429" mass="47370" checksum="9BA499B6C4EE21FB" modified="2011-04-05" version="1">MALSFAFCLGGLCLNRQAHAQDSSQTTEFKAKPGEGQAAATLSGRADSGPDLRPFLGGIYPEDLAPLLSVKLPVIVFAHAHRIRAYGWVDGGITTVSHASGLVIEAPTANRFSNQLMLNGAWLIIDRSTTQKLSLGFRTDFYVGSDAALLRPLDNFGPGSARWGTDFRQAYLLLHTPFLFKRGIDWAGGRINNPTGYETLMSPYRPLYSESYYWIHYEVGSTALQATLHPAARLDLVLGVVMGYNTAFELRGRAPDYIARAIYRPSGRKERQWLATVYSGPEPASAIKGHIGSWQTLSELQAREVWTPRISQVLQVHYMADTSDPANGRHTSSTQGAFAITSFKFSDKAYLNTRVEWFSDPHGVRVATPGTYSEATVGLNLHPRTYITFRPELRGDFAGQQSFGSTDAQARRHNQLSAAFELTFKAHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N9</accession>
    <name>E8X7N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4536</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71473">
        <property type="protein sequence ID" value="ADW71473"/>
        <property type="gene ID" value="AciX9_4536"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4536"/>
    <dbReference type="HOGENOM" id="CLU_2493549_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9632" checksum="387AABE67518FA37" modified="2011-04-05" version="1">MESFVYLLVPTCLYVAWRIIVAQRKIEPEDISGLPGTGPIRLGNGLHAYRSKAKSVVKSAPGRVAVMPPSDWKKVEEHRYPQRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q3</accession>
    <name>E8X7Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4554"/>
    <dbReference type="EnsemblBacteria" id="ADW71487">
        <property type="protein sequence ID" value="ADW71487"/>
        <property type="gene ID" value="AciX9_4554"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4554"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017156_0_0_0"/>
    <dbReference type="OMA" id="WPARIEN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230322" evidence="1">
        <location>
            <begin position="26"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="606" mass="63567" checksum="A3DFF30A62728DAA" modified="2011-04-05" version="1">MISLQRIVALICLVIGAFSSVAAIAQSQGILAQNLGSGPYTIKSLSNSSVCVDLSGANPTNGTAVQSLSCNGTVAQTWSLAPISTASGTAYQVVASVSGSCVDVSGASQADGAPLLEWPCLGANHSNQLWQMFAFGTSYELVSVNSGKCIDLAAVNSSSATQLQQWTCSGGTDTGQLWNLGVIPPTNTGVPTSPPAPTTGATVDLSTGEQAFQADAFVDSIGINTHITYQDTPYWSAWPTIFTSLEALGVHHIRDGFYSWPVGSAFYTEHQALAKAGIKTDYVFSIDNSTTPLVVQTFANIVQDMESIEAPNECDAGQNCGGGGLAGINNVAAFMNTMSAVGSSLNLPILGPSFTTDAGYAKAGQLGTKMTYNNMHIYFGGRNPGSTGWGGGDAEGNNYGSFAWWMDQAHVDAPSAPIMITETGYMAYTQTNTPYTLPESIEASYVPRTFALAFNHGIKRTYIYELLDEVSSPGYGLLRSDLSPKPAYSAMKNLISLLSDPGTTFTPSKLTYVVSGADESLSHTLLQKRDGSFWLALWLEQSSYNPATNTSTPVASQQVTISISGGLGVKQILQMDNTGAANSITGTGSTVSLPLNDQMALIQIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R4</accession>
    <name>E8X7R4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4567"/>
    <dbReference type="EnsemblBacteria" id="ADW71498">
        <property type="protein sequence ID" value="ADW71498"/>
        <property type="gene ID" value="AciX9_4567"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4567"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_1_0"/>
    <dbReference type="OMA" id="RENTHVW"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="332" mass="38129" checksum="4DCA02AB4F579E6D" modified="2011-04-05" version="1">MSLASHPCCITVNKNWEASILISIVVPVYNSVATLKRALDSVQAQTFSDWELIVVDDASSDGTVKLAKQLYSSDNRFRFILKEVNTGPAESRNLGFDQARGEWIALLDADDSWLPNRLAELLSASSDSDLIADNLMTYDVSIRRETGPYYKDFSTPVLTLADYLIGWLGNTELDGGYLKPLLRTSFLRTHNLRYDCALRHGEDYLLYCKALCWGARFKLINSCNYIYTTPIGWYSKEKSVHTRTIPDPIALAKAMQHFRTEICDRLCARDKDLYDRKIAELYATENWWAFEGAWRAKNYFLCLYLLRYSAVRKGFWVVLLSKLNLYTPTRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R8</accession>
    <name>E8X7R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4572</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573221.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4572"/>
    <dbReference type="EnsemblBacteria" id="ADW71502">
        <property type="protein sequence ID" value="ADW71502"/>
        <property type="gene ID" value="AciX9_4572"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4572"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_0"/>
    <dbReference type="OMA" id="NFHGPWA"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="41562" checksum="2D024E30EB42E034" modified="2011-04-05" version="1">MSSSAYLPDLQHPLALHIGIKYGSGGEGRVFSELSKYMPSAGIDLIGVVGGPDDVSQFTQGKVVNFALDGAGMANRLMGARKVIGQILKQSRPDIVGSHFALYTAPALDLMKGLPKVTHFHGPWADESKQEGSSSGAAFAKAQVENYVYRNSDRVIVLSKAFAELVTDRYSVNPEVIRIVPGSVDIQRFSLADTRQDARLHLGLPTDRPILLSVRRLVQRMGLSNLIEAVAAISKVIPDVLLCIGGEGGLRSSLERQVREHNLTKYVRFLGYIDEASLPRLYRAADINVVPTLALEGFGLVAAEALAAGTPSMVTPIGGLPEVVASLSENLIFRSSSVEDLADGLIAGLLGKVKLPSQSNCESYARENYNSTLMAERTVAVYRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V0</accession>
    <name>E8X7V0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_4604</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71534">
        <property type="protein sequence ID" value="ADW71534"/>
        <property type="gene ID" value="AciX9_4604"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4604"/>
    <dbReference type="HOGENOM" id="CLU_025132_0_0_0"/>
    <dbReference type="OMA" id="SLWYYLP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="120"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="676" mass="74977" checksum="2664539C6943D24C" modified="2011-04-05" version="1">MLVCMPKSTRFDSLRARGQTFAWILIVSLLAVFSLQLVHVARLYSANWDEAHHLYDGYLILTQHDYRANAEVPPLVKITAALPLLRMHLALPGSTGTPQTENAFLGGRTFVFANGGDRLLFPARMACMLFSLVTALLVYATGRRFFGMLAGVCSLFLFVFDPNLLAHGTLISTDVGSACFFLATVYAFYLYSVQPSWKVLLVTGLLAGLALVTKFTGILIAPILLLIAVVEGVRERRPATAARLLGASFAVLACAWLVLWAFYGFRYAAAPHGLQLSPTLGEYLASLPNPAQGAKLALFARFHLLPQAYIWGLANTKHIEQEYTSYFFGHVYRHGPWEYFPAAFFIKSTLPLLLLLLLAPLLWLKEGRAYGRQMVFLLVPVCVYFAVVTTSHFDIGARHLMPVYPFLYVLAGAIAAMFLRRGSGWAALAAALLLWQVVTTVRIAPNYMAYGNEAWGGPLQVRHYLSDANVDWGQQLKTVKQYLDQQHDPDCWFAYFPDGAVQPQDYGIHCHRLPTPSGLWWFTLPMEVPPQINGTVLISESDLEGVESGDGALNPYEGFQKLKPTAILQDGVYVYQGSFAVPLASAWVDVRQSAALVQKDELQQALLLAQRAVTLAPQSARTQLQLADVLAAETQWNSAKKHYQLAQENLLNHRPDLEQEELGIRIQNGLDAAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X821</accession>
    <name>E8X821_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4676</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71605">
        <property type="protein sequence ID" value="ADW71605"/>
        <property type="gene ID" value="AciX9_4676"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4676"/>
    <dbReference type="HOGENOM" id="CLU_010686_0_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13712" checksum="60EF90C50C3EA99A" modified="2011-04-05" version="1">MENCKFVSYLRVSTVRQGTSGLGLEAQRAAVAVFLNGGDWILVQEVLEVESGKSNDRPALATALKLCRKHRATLVIAKLDRLARNVAFISNLMESGVEFVAVDMPQANRFVVHILAAVAEQEAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY9</accession>
    <name>E8WVY9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 6">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3748</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582056.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3748"/>
    <dbReference type="EnsemblBacteria" id="ADW70748">
        <property type="protein sequence ID" value="ADW70748"/>
        <property type="gene ID" value="AciX9_3748"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3748"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_5_3_0"/>
    <dbReference type="OMA" id="WHYIIET"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="216" mass="22935" checksum="8CC48B58E1427F51" modified="2011-04-05" version="1">MTEQTILEKLKEGARRFQSEVHAGNAAEYERAATTPQQPHTLVIACADSRVDVESITSSGPGEVFITRNIGNMVPAYGEMLGGVSAVIEYAVSALKVKHIVICGHSDCGAMKALLSPDSTAAMPTVRSWLTNGQAALKVADALDTPDDKPGQRLRNLTEQNVLMQINHLKTHPSVAGALARNEISISGWVYDIGSGGVRVAEDPSRAFIPVSASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW30</accession>
    <name>E8WW30_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding lysin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0262</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578664.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0262"/>
    <dbReference type="EnsemblBacteria" id="ADW67336">
        <property type="protein sequence ID" value="ADW67336"/>
        <property type="gene ID" value="AciX9_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0262"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789327_0_0_0"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="37496" checksum="54DD4BD7692B2AC0" modified="2011-04-05" version="1">MSETTFPRFKRYRVKRGDTLWKIANHAYGHGDLWPGISYANHLKRGKPIAIGLDLIIPPAGSARHRAASKPESQPTASVTPVTKTLTPPLPPPPPSPMPVHDHATEKLNEATRSGPFEHARPVLFPAFKYELAGVIAQTETPVAELKLSLKGEVTLQKEGVITGGLTLTKEGMESEYKKEADGVFKDLFTKSTASVKDGKAEVALAVGSTIRSGDKVLATTEFALVPPNGFKYTYQGQKIKGTYHGFEFEGVVGYELEVKVKGGLPPEPKKFEIHVPVWTKVLGIAMVIGAAICYLAGGVVVVADAVKDFFTAGAGLVETPLSYAAALALFASGAAMWHHGSAKVSGKEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW57</accession>
    <name>E8WW57_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0291</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578691.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0291"/>
    <dbReference type="EnsemblBacteria" id="ADW67363">
        <property type="protein sequence ID" value="ADW67363"/>
        <property type="gene ID" value="AciX9_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0291"/>
    <dbReference type="eggNOG" id="COG3108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080400_1_1_0"/>
    <dbReference type="OMA" id="KSYHMKG"/>
    <dbReference type="OrthoDB" id="2028958at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010275">
        <property type="entry name" value="DUF882"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37425">
        <property type="entry name" value="PTHR37425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05951">
        <property type="entry name" value="Peptidase_M15_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233424" evidence="1">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="22215" checksum="C84241E26F10FA9E" modified="2011-04-05" version="1">MQISALKRCVAVAAAVLVLGLSGSSKAKAATGTGNTANGTHTLASAEQYVLHLHHLHTGESLDVVYRIGDTYVPEAMAKLNYFLRDHRTNDVSSYDPKEFDTLHELMAKLGRGNQTIDIVCGYRTPWSNNFLRTRSSVTGVAQHSQHMLAKAIDIRVPGVQTRTLRDMALSLHAGGVGYYPVSQFVHVDVGPVRQWAFGGRGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF2</accession>
    <name>E8WWF2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2591</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2591"/>
    <dbReference type="EnsemblBacteria" id="ADW69616">
        <property type="protein sequence ID" value="ADW69616"/>
        <property type="gene ID" value="AciX9_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2591"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="PVMFMDE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="28088" checksum="F7EEE584F5514564" modified="2011-04-05" version="1">MIPAVQTTALTRSFGEFTAVRDVNLSVAPGQFFGFLGPNGAGKSTTIKMLTGLLAPSSGSIQILGESLTAETVELKRHIGVVPEGLALFGRLTAPEYLRFVGQMYGLDAGVTAQRSAELLDFMSLTGDSKKLITDFSHGMQKKLALSAAVIHGPKVLFLDEPFEGVDAIAAGTLKSMLQGMIARGATIFLTSHVLEIVERLCTHVAIIQKGSLVAQGSLEELRAGVQAQHPESGRTEKATLEEIFLNVLGTTGVAPPEQELSWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG0</accession>
    <name>E8WWG0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2599"/>
    <dbReference type="EnsemblBacteria" id="ADW69624">
        <property type="protein sequence ID" value="ADW69624"/>
        <property type="gene ID" value="AciX9_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2599"/>
    <dbReference type="eggNOG" id="COG2930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_4_0_0"/>
    <dbReference type="OMA" id="PTATGDH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005345680" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="104"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="24347" checksum="25EB0A2CC986147B" modified="2011-04-05" version="1">MNKQFAGSVAALALIAGAVQVSMAQGDKPKLDERLGSAKAVIQEIMATPDKGIPQSILSSASCVVVVPSFKKGAFVVGGQYGQGVATCRTPHGWSSPVFVRLEGGSFGFQIGGQSTDLVLIAMNKNGLQDMLKAKFKLGADAAASAGPVGRNAQAGTDWKLNAEFLTYSRSKGLFAGLDLDGTVLSQNGDDTRAFYGSDVPFEGVLEGNQPTPPAARPFVGTVAKYFIVSRDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ3</accession>
    <name>E8WWJ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2632"/>
    <dbReference type="EnsemblBacteria" id="ADW69657">
        <property type="protein sequence ID" value="ADW69657"/>
        <property type="gene ID" value="AciX9_2632"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2632"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_0_0_0"/>
    <dbReference type="OMA" id="TNDARRI"/>
    <dbReference type="OrthoDB" id="1384807at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="32962" checksum="ACAD98FE81A5BFD7" modified="2011-04-05" version="1">MVVACGVGGGQAPIERRAPEQAVTTLKAESRLVNVAVNAVDAQGAPVGGLSKADFVISEDGVAQKIAFFEKESATPLSIVMAIDGSESVVTNDRLEKEAGKKFVRALLREQDEFDLMDFSDTVREVVSFTNDKKRIENGLNELRKGDATAVYDAVYLASQRLGETNAGGGRRRVLVLITDGDNTVHGVGYDQAVEQAQRAGVMVYALIVVPIEADAGRNTGGEHALIQMATDTGGNYYYVNDPRDLAKVYAKVSDDLRTQYVLGYYAPEKTVKSRRDGYRKIGVSLVDSQGVSLRYRTGYYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK0</accession>
    <name>E8WWK0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2639</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2639"/>
    <dbReference type="EnsemblBacteria" id="ADW69664">
        <property type="protein sequence ID" value="ADW69664"/>
        <property type="gene ID" value="AciX9_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2639"/>
    <dbReference type="eggNOG" id="COG3237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2232749_0_0_0"/>
    <dbReference type="OMA" id="THERNKP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="105" mass="11280" checksum="4879C09B81B4FA2B" modified="2011-04-05" version="1">MNEDKATGVLDQVKGSVKQAFGEATNNQSLANEGAADQVKGHAKEAWGSVKDTASNLNHSRDAEDAKLHTEQNAHSFRDSVTNAAESAKESIQRGLHNLEHKAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN0</accession>
    <name>E8WWN0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ordered locus">AciX9_3775</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3775"/>
    <dbReference type="EnsemblBacteria" id="ADW70775">
        <property type="protein sequence ID" value="ADW70775"/>
        <property type="gene ID" value="AciX9_3775"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3775"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_4_0"/>
    <dbReference type="OMA" id="WNAKTNL"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22555" checksum="761386BFBF961B5F" modified="2011-04-05" version="1">MTVRTPKPMPTLPKSRIAALLAPYYPATDELITQLSDYLDLLLRWNARTNLTAIRDPEEIVTRHFGESLFAAANLPEGNTLLDLGSGAGFPGLPIQLAHLDLLVTLAESQNKKSTFLREAIRTLGLKTQVHAARAETLTAPFDIVTLRAVDDMQLALAAALPLASNAIVILTTTRQAQPSLENFTLQPPIPLPNALDHQLLIALRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR5</accession>
    <name>E8WWR5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="2" type="ordered locus">AciX9_0321</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578721.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0321"/>
    <dbReference type="EnsemblBacteria" id="ADW67393">
        <property type="protein sequence ID" value="ADW67393"/>
        <property type="gene ID" value="AciX9_0321"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0321"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_0"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="22200" checksum="A8882D25411BB37E" modified="2011-04-05" version="1">MRLIVGLGNPGIEYQFTPHNAGFLAIDRLAEVFGTAVNNRRGKALTGKAVISGQEVLLAKPETFMNLSGLSVAALLQELGLSHQSDLIVLYDELAIPLGQLRIRERGSAGGHNGVKSISGVLGSEEWTRIRIGVGKQPTETGREIKAGGVDYLLSPMRRMMLQELDLVLDETVKAVETILKEGVKAAMNKFNRKVNGEDPEGPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR6</accession>
    <name>E8WWR6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="7" type="ordered locus">AciX9_0322</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578722.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0322"/>
    <dbReference type="EnsemblBacteria" id="ADW67394">
        <property type="protein sequence ID" value="ADW67394"/>
        <property type="gene ID" value="AciX9_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0322"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_4_0_0"/>
    <dbReference type="OMA" id="ETIFLVK"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="18051" checksum="263BBF1C6D0A30DD" modified="2011-04-05" version="1">MNRTYEIMFIVRPDVEEADLDKLVEGFQKNITDGNGEVKSIEKMGRRRLAYTVRKFNDGFYVLMNIAAEGQLITEIERRLRVSEPVIKFITVRMDEEEKRLAKIKAHRDTHVKRSAIPQQIQQPVPAAAAPVEASAEPVAETPAEAPVAAAPVAEAEPVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW2</accession>
    <name>E8WWW2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579843.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1470"/>
    <dbReference type="EnsemblBacteria" id="ADW68523">
        <property type="protein sequence ID" value="ADW68523"/>
        <property type="gene ID" value="AciX9_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1470"/>
    <dbReference type="eggNOG" id="COG4320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032121_0_0_0"/>
    <dbReference type="OMA" id="QFRDMKD"/>
    <dbReference type="OrthoDB" id="571864at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="48798" checksum="377C49EB5FE0F544" modified="2011-04-05" version="1">MKTAKHVPADLTHGQKARKVVARSGHQQWSPEHREQSAQDILKAAMRGRIPKLLKLRDERMAATAFGYFRGAVPVMAYDLGRRPHTGILCQLCGDAHVLNLGAYAGYDGSLIFDINDFDETIQGPFEFDVKRLATSLILAGREAGAKEREARAAAAVFLKRYRKSIHLFAALPILEMARYQIHRQVQLDALTTVFAKAEHSSPLHNLDTLTEPAKTKDGDLTASRRFKSNPPILTRLSPAESAPILASLAEYKRTLQPERRHFLAGYRPVDVAFKVVGTGSVGLRAYCIYLEGNGPADPLFLQIKEEPASAWAPYLPASVRPKLNEGRRVENGQRAMQLQSDPFLGYTTIDGRDFLVRQLNDHKASIDFLGLGPAALCHYADLCGELLARGHARSGSSLMIAGYLGKTDRFDKAILRFATAYADQTEHDWKDLLRTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX0</accession>
    <name>E8WWX0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="16" type="ordered locus">AciX9_1478</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579851.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1478"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="ADW68531">
        <property type="protein sequence ID" value="ADW68531"/>
        <property type="gene ID" value="AciX9_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1478"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_1_1_0"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="81"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="201" mass="22102" checksum="7C80BB50A1762DCB" modified="2011-04-05" version="1">MAITRRQKEVIDFLSGFTTKNGYSPSYEEIASGLGLNSLATVHKHITNLQNKGLLQRAHNRSRSIDVLPARTSKKGFERLPLLGRIAAGQPVEAIETAESISLGDIIGNREVFALEVRGDSMRDEHIVSGDYVLVERTRTAREGEIVVALIDGADATLKRFYREGAMIRLQPSNKEMAPIYAPAANVSIQGKVLGIIRKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX4</accession>
    <name>E8WWX4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1482</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579855.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1482"/>
    <dbReference type="EnsemblBacteria" id="ADW68535">
        <property type="protein sequence ID" value="ADW68535"/>
        <property type="gene ID" value="AciX9_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1482"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145200_0_0_0"/>
    <dbReference type="OMA" id="QSDNGWQ"/>
    <dbReference type="OrthoDB" id="2021245at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233934" evidence="2">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="15225" checksum="3C535FD7699CAB7E" modified="2011-04-05" version="1">MKLVSSSILSSIVLLASVAPAFAAAAPHIRRGPTSQRAFKSRAVSKPVTRSSSVSGISGERATQIQSALIKQGYLTGTPTGTWDKESQAAMEKMQSDNGWQTKLVPDSRAIIKLGLGPNSTASAEPESMEAHPTALTENTFAANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE4</accession>
    <name>E8WXE4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="5">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hslV</name>
        <name evidence="7" type="ordered locus">AciX9_0405</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0405"/>
    <dbReference type="MEROPS" id="T01.006"/>
    <dbReference type="EnsemblBacteria" id="ADW67477">
        <property type="protein sequence ID" value="ADW67477"/>
        <property type="gene ID" value="AciX9_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0405"/>
    <dbReference type="eggNOG" id="COG5405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093872_1_0_0"/>
    <dbReference type="OMA" id="IMKGNAR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="22427" checksum="BEB0DA81B1A377CC" modified="2011-04-05" version="1">MSDSLTKRVGIGASGHPSGHPLDLGEGRRIRSTTVICVRRGDSVVMAADGQVSLGGTVMKSSAKKIRRLYNDKVLAGFAGSTADAFSLFGRFEAKLEQYAGNLGRAAVELAKDWRTDKMLRQLEALLVVADASQTLMLSGTGDVIEPDAMRPGEGIMAIGSGGSYAQAAALALMENTEMSAREITEKAMKIAADICIYTNERITVEELKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ4</accession>
    <name>E8WXJ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MgtE intracellular region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1557</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1557"/>
    <dbReference type="EnsemblBacteria" id="ADW68610">
        <property type="protein sequence ID" value="ADW68610"/>
        <property type="gene ID" value="AciX9_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1557"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030870_1_0_0"/>
    <dbReference type="OMA" id="PARRDWE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="423" mass="46146" checksum="9543CCFB90B55403" modified="2011-04-05" version="1">MNRQANQRTSVSALMGVAIADASGRLMGHVTEFAVAPTVDACRVESLVVRRSGESRKVAPAMVRVSSLCWNDAGKLQVADGAPTAVVLDDTDKYLLLERDLLDQQIIDVHGHKVVRVNDVDMVWEAGDGDCALSLRIAEVEVGIRGAVRRLLKGLPQDAVEALASRAGARVIPWDFVDLIDRDPARRVRLKIEQDRLSKMHPSDLADILEELAPAEGQALFSSLDEEVAAEALEEVELKTQKSLIESLDSETAAGIIEEMDPGAAADLLAELSEERSDAILEEMGEKERHDVEELLEHAPDSAAGLMTTDFVAVGVDGSLDDAVKALEEFDGDLETVTEIFLVDEERLVGQVPMARLMVTKSGGLKEIAEEHVVSTGEAENGRKVAELFDKYNLRSLPVLDEDKKLVGVIRAEHVIGWLRMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK0</accession>
    <name>E8WXK0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1563</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579935.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1563"/>
    <dbReference type="EnsemblBacteria" id="ADW68616">
        <property type="protein sequence ID" value="ADW68616"/>
        <property type="gene ID" value="AciX9_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1563"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124392_0_0_0"/>
    <dbReference type="OMA" id="ATFAIPN"/>
    <dbReference type="OrthoDB" id="1564596at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="18205" checksum="A53CED8DBF9BB7A9" modified="2011-04-05" version="1">MNSKKIRSALQGNHEEGFTLIELLIVMSVMLILMTLAIPQLLKLRKTAAETSAIASVKAIGQAELSYNSAYPQNGFSCSLASMGGVPGSGAPSAQAAQILDPTLAAGQKQGYTFNITNCTKVTVNNQDMFTGYEITAVPTSIGRSGDRGFCMDENNIMKTDAAGGTNCTTTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL5</accession>
    <name>E8WXL5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1578</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1578"/>
    <dbReference type="EnsemblBacteria" id="ADW68631">
        <property type="protein sequence ID" value="ADW68631"/>
        <property type="gene ID" value="AciX9_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1578"/>
    <dbReference type="HOGENOM" id="CLU_2105522_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="15413" checksum="D2DE282F6CC850F9" modified="2011-04-05" version="1">MILGSVPGLYPSRLHLLADTSLLVGVLLIVFASLRGGLNQPKRALILIGYCNLAFWLSYVVWMLRLKMVGPSPDIGIDPFAGVLAEWFVLLVLGSAYEVIVFTRGIFSQQQRRIALVGMGVLLIQILTSIQVSYRLLQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW0</accession>
    <name>E8WXW0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2782</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581120.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2782"/>
    <dbReference type="EnsemblBacteria" id="ADW69805">
        <property type="protein sequence ID" value="ADW69805"/>
        <property type="gene ID" value="AciX9_2782"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2782"/>
    <dbReference type="HOGENOM" id="CLU_1903754_0_0_0"/>
    <dbReference type="OrthoDB" id="2224326at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14758" checksum="64B1492AD9DFBFB5" modified="2011-04-05" version="1">MNESAKVLLIGNDKAHLEARAEVLTYFWSVATAALDQSEAPVLETDLVVLCHTLPEAERQEWVTRIRHEVPHMLIVKMNGYDSGPHAGADATVDVENGPGALVSTIYELLTERGLSSRAWPENQRERFLVGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY1</accession>
    <name>E8WXY1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0448</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67520">
        <property type="protein sequence ID" value="ADW67520"/>
        <property type="gene ID" value="AciX9_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0448"/>
    <dbReference type="HOGENOM" id="CLU_2342808_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10195" checksum="832DC6100AAF15EE" modified="2011-04-05" version="1">MTTVKQKQKQKQRQRQRKSNGKRKCNSSGKCNSSGKCKCNGSGKCNSNGSGKYNGSGKCNGSGKCNGSGKCNGSGKSNGSGKCKCNGRSRFLRFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY34</accession>
    <name>E8WY34_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0501</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578901.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0501"/>
    <dbReference type="EnsemblBacteria" id="ADW67573">
        <property type="protein sequence ID" value="ADW67573"/>
        <property type="gene ID" value="AciX9_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0501"/>
    <dbReference type="eggNOG" id="ENOG502ZQNI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823317_0_0_0"/>
    <dbReference type="OMA" id="WYAAAHE"/>
    <dbReference type="OrthoDB" id="1278010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="37645" checksum="98CB80756F4FF2F8" modified="2011-04-05" version="1">MIWTRVVLGLVLGAGLLHGQQTAHVVSAEPDTDKDGLSDELEQRLLTQFAPSFMVGKDDCSNVPAEFVPEMKVPTVKTEDGTIYGQAFPVKSSSKDAPEVEIHFYHLWRIDCGRHGHPLDTEHVSALVRASGPDVLTAKWTAVYWYAAAHEQTVCDVSQIARASTLHAEEHGANVWISPGKHASYLNETLCQRGCGADKCEQMTALPAARIVNLGEPGRPMNGSVFVASNQWPLLGKMEATNFPAEPLGRLEKLPETDIAWYSAGRHPAQQIISISGRTELKLANSADNTGSAISTAGDATGGALSTAQDSTGNALGKSYRKTTHALGTSARHVGQALHVTPKDDPAKQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY58</accession>
    <name>E8WY58_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="4" type="ordered locus">AciX9_1633</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580004.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1633"/>
    <dbReference type="EnsemblBacteria" id="ADW68685">
        <property type="protein sequence ID" value="ADW68685"/>
        <property type="gene ID" value="AciX9_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1633"/>
    <dbReference type="eggNOG" id="COG2107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070326_0_0_0"/>
    <dbReference type="OMA" id="RGCGPLV"/>
    <dbReference type="OrthoDB" id="1107067at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="284" mass="31455" checksum="C094B3C7D31CF422" modified="2011-04-05" version="1">MSVALPTIQEIHVAHSPDSDDAFMFYGLATQKVRVPGFKFTHNLTDIETLNHKAIKEAIYDVTAISFHAYPYMQENYALMATGSSFGEGYGPMLVSTKKYTIDQVKKLRIAIPGTLTSAFLTLKLFCPEIETAVVDFDKIIPAVVAGEYDAGLLIHEGQLTYAHDGLVKILDLGQWWRDLTGLPLPLGGNAIRRSLGPEVMLSTAHAVRDSIQHALDNREAALSYAMQFARDLDPNLASRYVGMYVNDRTIDMGEDGREAIRRILGMGYERGIIPIESKVDFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY61</accession>
    <name>E8WY61_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase domain protein FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580007.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1636"/>
    <dbReference type="EnsemblBacteria" id="ADW68688">
        <property type="protein sequence ID" value="ADW68688"/>
        <property type="gene ID" value="AciX9_1636"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1636"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_1_0"/>
    <dbReference type="OMA" id="KFECEYH"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23165" checksum="D85A1D80E79D8C73" modified="2011-04-05" version="1">MVFDVATTDKKKIYNLLIGLVAPRPIALVTSRNEDGGINAAPFSAYNYLSIDPPIVALGVADRPAGDPAPKDTARNIRRTGEFVVNVTTEDLLRQMNICATDFPAEVSEIEMAGLETAESSVVSVPRIKSAHAALECVEHTTLQIGRSRIILGRVVAMYVEDQFVDPAGPYIKAEELHAIGRMNGLGSYVRTEGSFLHQPRIPYSEWVKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA2</accession>
    <name>E8WYA2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1679</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580048.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1679"/>
    <dbReference type="EnsemblBacteria" id="ADW68729">
        <property type="protein sequence ID" value="ADW68729"/>
        <property type="gene ID" value="AciX9_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1679"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_0"/>
    <dbReference type="OMA" id="YRNPMVV"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="385"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="725" mass="80081" checksum="01F9C8C3BCDD43A2" modified="2011-04-05" version="1">MARQTEGALATRQETAGKYPLSNEQLIEFYRLMYLSRRVDDREIVLKRQQKIFFQISCAGHEALLVAAGMALKPSYDWFFPYYRDRAICLALGNTAEEQLLQAVGAAADPASGGRQMPSHWSSSKLNIVTPSSSTATQCLHAIGCAEAGRYFSQHPESAAKVDGDYREFKNVKFHGDEVVYVSIGEGSTSQGEFWESLNTASNGKLPVVYVVEDNGYAISTPVEANTPGGNISRLIANFPNFHFAEIDGTDPIACYNAMTEAVAYCRAGHGPALVHGHVVRPYSHSLSDDERLYRSQAELQADALRDPISRMQVWLMREGILDADGINALERKVDLEVQQAADVAVAAALPTVDSILKHQYSEDLSCTDARFATEPAPSDDPTERTMADLINTCLRDEMRRDQRIVVFGEDVADATRAEALLDPKVKGKGGVFKLTAGLQVEFGSDRVWNSPLAEANIVGRAIGMAVRGMKPVVEIQFFDYIWPAMHQMRNELALIRWRSNGDFSCPLVMRVPIGGYLTGGSIYHSQSGESIFTHTPGVRIVMPSNALDAIGLLRTAIRCDDPVLFLEHKRLYRETFGRAMYPGPEFAIPFGKAKIVRPGKDLTVITYGAVIPRALQAAVKLHRETGIDVELIDLRSLAPYDWEAIAKSVRKTSKVIVAHEDMKSWGYGAEIAARIGEELFDDLDAPVRRVAAMDTFVAYQPILEDAILPQPEDLYRAMADMAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT8</accession>
    <name>E8WYT8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580093.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1726"/>
    <dbReference type="EnsemblBacteria" id="ADW68774">
        <property type="protein sequence ID" value="ADW68774"/>
        <property type="gene ID" value="AciX9_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1726"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_0"/>
    <dbReference type="OMA" id="RGNCYLE"/>
    <dbReference type="OrthoDB" id="275025at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="208"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="470" mass="50751" checksum="DFD37523B0990979" modified="2011-04-05" version="1">MAGLTAAVAFAKDNGDRFVEELKELIRIPSVSTDPERVGDTRRAAQFVADELARIGMENVRLIETSTEPSATGPGRQGHPLVYADWLKLPGKPTVLCYGHYDVQPAEPLEEWLSPPFEPTVRDGNLYARGAVDDKGQMWMHVKALEAMMVAGGGTLPVNVRVIVEGEEEVGGEGIAAFVREHGDQLKADVALVSDTEMFAPELPTLCVGLRGMIYTEIEVKGSRTDLHSGMYGGAAPNAFVGLAQLIAKLKDEDGRILIPGIYDKVQRPTDAELKAWKALPFDEEEYREAEVGSVALTGEAGFSVLERTWARPTLDVHGMPGGFIGAGAKTVIPAKATAKVSLRLVPDMTPAETFGLLRDYVATIVPKGCTAEVRMIHSGDPIVVSTDNRFVAAATEAMQTVFRKDTVFVRGGGSIPIVGDFVRELGIPTVMMGFGLPDDNLHAPNEKFNLSNFHRGIESIVRWMGLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV3</accession>
    <name>E8WYV3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1741</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580108.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1741"/>
    <dbReference type="EnsemblBacteria" id="ADW68789">
        <property type="protein sequence ID" value="ADW68789"/>
        <property type="gene ID" value="AciX9_1741"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1741"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_5_0_0"/>
    <dbReference type="OMA" id="CEWGQEN"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233995" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="378"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="454" mass="50672" checksum="65EBD91B4558B313" modified="2011-04-05" version="1">MKLSRCLKALALTLICSPLASAQANKTLAAQPPMGWNSWDAYGLTITESQFRDNVDVLAKTLKPFGWNYAVIDEGWFLKNPLDRGTPDKLAYQIDANGRYIPVPARFPSALINNQNTGFEALGTYVHSQGLKFGIHIVRGIPRQSVADSLPIANSKFHAQDAADTTDPCPWDPTNWGVRDTPAGQAWYDSLLAQYAAWGVDYLKVDCISDHPYKPTEIRMLHRAILKTGRPIILSLSPGPTSPGIATELIPYAQMWRISDDIWDYWTNTRHFPRSLHDQFELAAAWAPYARPGTWPDADMLPLGFLGPIPGDGEARQSRLTHDEQQTMLTLWSMARSPLILGANLTKLDDWTTKLITNPDVLAVDQFGHDQRQVAREGNAVAWTSAGKGDIRYLALFNLNDKDKTIDRTYAFYNLPAGSYRARELWSHTDRGVSTAIHVTLPPHACILLELQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV7</accession>
    <name>E8WYV7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1745</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580112.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1745"/>
    <dbReference type="EnsemblBacteria" id="ADW68793">
        <property type="protein sequence ID" value="ADW68793"/>
        <property type="gene ID" value="AciX9_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1745"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_4_0"/>
    <dbReference type="OMA" id="TADDGIC"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233502" evidence="5">
        <location>
            <begin position="27"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="51725" checksum="1326AEF680837625" modified="2011-04-05" version="1">MGTTHLISRRHFLWTTASLLSTPALAFPTSPIDYDVRTFGAIGDGIAVDTAAIQRAIDTAAQNGGGRILIPGGKRFLTGALVLKSNVNFHLADDAMLLANPDPADYNGHLGLLNSDRARGLKISGTGMIDGQAMQFMTTFSQKDERWEPKKFRPRMFHLQRCMDLEITDITFGHSPEWGMHLLGCERVLVDGVRIRNFLEVPNCDGIDPDHCRDVEIRNCDIVCADDAIVIKTSDQAEDFGPSRNIVVKDCVVTSRDSGLKVGTETFSDISKILFERCKVLSSGRGPTITHRNQGNIDDIEFRDIELTTEHHAARWWGWGEAISVTAWPRKPDTKVGTLRNVRLRNIKGRSENSIRIDGQNNQPIEDVLLENIDMTIDRWTKYPGGKFDNRPTPPTMEGLEVHGTPVFSIRNAKNVTVKDCKARWGDHREDYFTHALEAENVQGLKITNFTGQAAHAGQKAIAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV9</accession>
    <name>E8WYV9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580114.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1747"/>
    <dbReference type="EnsemblBacteria" id="ADW68795">
        <property type="protein sequence ID" value="ADW68795"/>
        <property type="gene ID" value="AciX9_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1747"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_0"/>
    <dbReference type="OMA" id="MANGQCF"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="42390" checksum="6912C94E4D40FD13" modified="2011-04-05" version="1">MTPWLEIAVRLAAWAVALCWAAKLAAALWGLRGIADLLGAGWDRMPLGEPTITVVVPACNEERDVRACLESLVGQDYVGLDVVAFNDRSTDATGAIMDELGGRYPGRLRVIHVEALPDGWLGKTHAMASAASSTSSDYVLFTDADVVFRGDALRRSLAYAVESGADHLITLPTTIIKRWDEAALLGFFQILGLWGAPLWRVASARSRVAIGVGAFNLVRRTAYEQVGGFAALRMEIVEDLGLGKRIKQAGLKQRVAFGRGLVSLHWAAGANGIVNVMTKNVFSVFRFNVALMLVTCGWLVGFSIVPYVGLFYLPVLVPSLLMVGSVFGLYGLMSRHSGIPARNAVYAPFAAVMFVYTMLRSTLITLRQGGVIWRGTFYPLGELKKNAAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW0</accession>
    <name>E8WYW0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="6" type="ordered locus">AciX9_1748</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1748"/>
    <dbReference type="EnsemblBacteria" id="ADW68796">
        <property type="protein sequence ID" value="ADW68796"/>
        <property type="gene ID" value="AciX9_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1748"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_1_0_0"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="48230" checksum="8782ADD4ABCBDC55" modified="2011-04-05" version="1">MPSITRRNAVNVNVGGVIVGSGAPVVVQSMTNTDTADIESTVQQIAALARAGSEMVRITVNNDDAAKAVPYIIEGIQAKGWNTPIIGDFHYNGHQLLRKYPAMARALSKYRINPGNVSIGRKDDDNFRTMVECAVDNQKPVRIGVNWGSLDQALLTRMMDENSKSANPLDARDVMMEAMVVSALDNAAAAERYGLRRDQIVLSAKVSGVRDLVDVYTELAKRCDHALHLGLTEAGMGMKGIVASTAGLSPLLLSGIGDTIRVSLTPTPGGDRSEEVRCGQQILQSLGIRSFMPQVTSCPGCGRTTSTYFQELAERIQNYLVESMPEWKQAYPGVEELKLAVMGCIVNGPGESKHANIGISLPGTFEDPKAPVYIDGEFATTLKGDRIVEEFQVILDNYVQRRYGHSGGNGGGSHGAPSAGGPVNPNTIHADAVEDGTKKPVEPPIFAVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY1</accession>
    <name>E8WYY1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase, hydantoinase/carbamoylase family</fullName>
            <ecNumber evidence="4">3.5.3.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2873</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581211.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2873"/>
    <dbReference type="EnsemblBacteria" id="ADW69896">
        <property type="protein sequence ID" value="ADW69896"/>
        <property type="gene ID" value="AciX9_2873"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2873"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_6_1_0"/>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="OrthoDB" id="829830at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047652">
        <property type="term" value="F:allantoate deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="408" mass="42277" checksum="97F02AC84A3FB4CE" modified="2011-04-05" version="1">MSAAAERVVARCRELALISDVPGETTRTFLSPAMHAANDLVAKWMREAGLAVSMDAVGNLRGVMGSGPRVVMASHLDTVVNAGAFDGPLGVMVAVAAVEELRAVALSFAVEVIAFSEEEGVRFSTPFLGSRAVVETLDEAALGLTDAGGVSVAQAIRGYGLEVERLSEARLAKEAFAYFEVHIEQGPVLEAEGRAVAAVTAIAGQTRLRVRFEGQANHAGTTPMRLRKDALATAAEWIGLVEAEGLKVEGLVATVGAIIAEPGLGNVVPGVVTASLDVRHAVDSVRVTAVAQLLGAADDVAARRGVAMSQVLLLDQAAVGMDTRLTGLVRDAAEACGYGGGALVSGAGHDAMIVAPHVPATMLFVRTPGGVSHHPSESVSVEDVDAALKTTVEFLRRLKPETIERNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ62</accession>
    <name>E8WZ62_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0593</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0593"/>
    <dbReference type="EnsemblBacteria" id="ADW67664">
        <property type="protein sequence ID" value="ADW67664"/>
        <property type="gene ID" value="AciX9_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0593"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084768_0_0_0"/>
    <dbReference type="OMA" id="YIFCNIH"/>
    <dbReference type="OrthoDB" id="1869568at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230092" evidence="1">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26490" checksum="0EAED3EAF1C59A10" modified="2011-04-05" version="1">MRAANLPRWMKRCGLVMAAAAGMAHAQGATVDLRVNVESHRMNGAKTADGATEQVIAWLTPMKTDATHPPVPAHGYVLTQKNKMFTPHLLVVPTGSSVEFPNLDPFFHNVFSLFNGRRFDLGLYEAGSRRSVRFDHDGVSYIFCNIHPEMGAVIVSLSTPYYSVSRKDGSLAIANVPAGDYELNVWAENVSAADLAAARQNIHVSEQGLRLPAMTLQASSSMAGKHLNKFGEEYKKSDQDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA2</accession>
    <name>E8WZA2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0633</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67704">
        <property type="protein sequence ID" value="ADW67704"/>
        <property type="gene ID" value="AciX9_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0633"/>
    <dbReference type="HOGENOM" id="CLU_1084885_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="28576" checksum="E1C8EE5C991EB3AE" modified="2011-04-05" version="1">MLTMYLDESLEQNDGYAVVAGFIGNDESWNLCMRLWGESLARHNRPSLHMKDLRWKRNRHTAMLADLGGIPSQCGLTLVYASVKVSDYLDLIQGTLGEVIASGYHLAMLMVLGYSMAVLPPEDRVEVICEQQDEFSGVRESFLKLAFEMEEWKTPGGLPRVAKWSAIPKSRILEPSDFAAYALLQALRDVKSKKTEMCAPILLNPRTMGHCIGREEARIGVSGFIAQTKDGAIAQISSKARAYVRRRFNAEYGGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA7</accession>
    <name>E8WZA7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0638</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579037.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0638"/>
    <dbReference type="EnsemblBacteria" id="ADW67709">
        <property type="protein sequence ID" value="ADW67709"/>
        <property type="gene ID" value="AciX9_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0638"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_7_0_0"/>
    <dbReference type="OMA" id="KELKGHW"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="28052" checksum="80CCB278ABE057EA" modified="2011-04-05" version="1">MFSSVSTHWHYLWLVTASLVAGVMNAMAGGGSFISFPAMLAMGVPPIEANATNTVALWPGQLTSLATLRGDIRRELLPVVLGTSVIGGVTGAEVLLHTRQLTFLHLIPWLLLTGALIFGISGPISRWLRARSIHAAAEHHGEPKIPSVPLALALLPICFYIGYFGAGGGFLVMTVLALFGMEQMHELNALKVVAACASNLCAIFTFIISGRILWHYCLISMVFAAVGGFVGARYAKTMNPSVLRAVVVITGVVIAGYFFWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD4</accession>
    <name>E8WZD4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1774</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1774"/>
    <dbReference type="EnsemblBacteria" id="ADW68822">
        <property type="protein sequence ID" value="ADW68822"/>
        <property type="gene ID" value="AciX9_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1774"/>
    <dbReference type="eggNOG" id="COG1612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053655_0_0_0"/>
    <dbReference type="OMA" id="HWPLCNG"/>
    <dbReference type="OrthoDB" id="1135592at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="33786" checksum="AA6EC7D151500045" modified="2011-04-05" version="1">MATAAMVSERVGVSRRAARFAWGVVGYNVLVVLWGALVRATGSGAGCGNNWPLCNGVAIPVSPTLHTVIEFTHRQMVTGDVIAIVAMLVWTFRATLKGAAARVFAVISTVLLVNEAFLGALLVKLGYVTGNQSVGRMVLLSVHLSNTLILVAALTMTARMLGTGQGWRGLRAKGMDKVAAVVGLVATLVVGVSGSLAALGDTLFPASSLRAAVAADLDVHSPWLLRLRGLHPLSAVVAAGFVVWLVVRARREGLGRGMNLVLGLLGLQFALGVLDVLLLAPAWMQMVHLLGADLYWVALVGLAAGVVWPMESRLAPLPRQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH4</accession>
    <name>E8WZH4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1814</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1814"/>
    <dbReference type="EnsemblBacteria" id="ADW68862">
        <property type="protein sequence ID" value="ADW68862"/>
        <property type="gene ID" value="AciX9_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1814"/>
    <dbReference type="eggNOG" id="COG4277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033784_0_0_0"/>
    <dbReference type="OMA" id="GYIHLKA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="45858" checksum="65BA3025E2C048B7" modified="2011-04-05" version="1">MLTTQEKLEILADAAKYDASCASSGAKRAGNGKGIGHSDGMGICHSYTPDGRCVSLLKILLTNVCTYDCVFCVNRVSSDIRRARFTPEEVVNLTLDFYKRNYIEGLFLSSGIIQSPDYTMEQLISVAKQLRQVHNFGGYIHLKAIPGASQLLIDEAGLHADRLSANIELPTQQDLVQLAPEKKSAIIESTMSQIAVRKDEADEDRRKSSLAPKFAAAGQSTQMVVGATPATDRQILTTATHLYGQYKLRRIYYTGFSPYPEADARLPLKAAPLIREHRLYQSDWLMRFYGFQASELTTESQPELSLTEDPKTTWARTHPEFFPVDVNTAPRESILRVPGIGYRNVERILNIRKYHALTREDLRKLNVRLKQSLPYLITTDHLPSSIIPTPEPTPEVQLDLFAPTSALTGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI6</accession>
    <name>E8WZI6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1827</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1827"/>
    <dbReference type="EnsemblBacteria" id="ADW68874">
        <property type="protein sequence ID" value="ADW68874"/>
        <property type="gene ID" value="AciX9_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1827"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_0"/>
    <dbReference type="OMA" id="LDLWDWT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="657"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="740" mass="79364" checksum="9B61289CAD216A7D" modified="2011-04-05" version="1">MSLSRLGCGVVAFGMLVGTGYAQAGGDAGAAYKDARRPVAERVADLLGRMTLEEKISLLSGSSWMESAGVPRLGIPAIKMADGPMGIRIWTGPSSQTSVETPVNRFSSTAFPAGINVAASWDPELARQEGQVIGQEVAAVGRDMILGPTVNIHRTPLWGRNFESYGEDPYLSGRMAVGYIKGVQSEGILPSVKHFTVNNEEFERHRIDVAVDERALHEIYFPAFEAAIKDAHVWTVMSSYNKVNGAYAAESPLLKQELYKEFGFKGFVVSDWGSTYSTAGTVNAGMDIEMPGGPPMRKWLAASGPHIAGNDGGYLVPEKVMPLVKSNEIPVANVNENAGRILTVIFESGLYDHQHVAGGAIDTPAQRALTRKAADEGIVLLKNQGGVLPLEAGKVKSIAVIGPGAATARAGGGGSGLVYAKNIVSPLDGIRARATGVDVRYALGAAMAGEEPEHDTAEAKKKRLNEAIAAAKDADAAVVFVGYSWKLETEGKDRPDMKLPEGQDEMIRAVAAVNKRTIVVLNAGDSVDLTQWVDQVPGLVDAWYGGEEGGNAVADILFGDANPSGKLPFTFLRRLEDSPSYGNYPGENLHVKYAEGIYVGYRYFDKHIDVPPLFPFGFGLSYTTFQYSDLKVHKGTGDEMATVSLTVKNTGARKGAEVAQLYVGQPHASVDRPVKELKGFQRVELAPGESRSVQFVLDRRAFSFYSVAKHGWVAEPGSFDLAVGSSSRDIRLESHFVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM1</accession>
    <name>E8WZM1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2972</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581309.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2972"/>
    <dbReference type="EnsemblBacteria" id="ADW69995">
        <property type="protein sequence ID" value="ADW69995"/>
        <property type="gene ID" value="AciX9_2972"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2972"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_0"/>
    <dbReference type="OMA" id="HHLVQRI"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="108"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="37651" checksum="9E2C1F0D2B3F45E2" modified="2011-04-05" version="1">MIKKALDITPGIEPLYGTRDENLRLLEDSLHVSIDLRSDAIHVSGEEAQVGRVAQIFADFDALRRGGVTLQNGELHALLKLVVADPASTLRGLVDSGKQRSAGVKRMVQPRSPNQKKYVEAIETSDMTFGLGPAGTGKTYLAVAMAVSALMAKKVSRIILVRPAVEAGERLGFLPGSLQEKVDPYLRPLYDALYDLLDQEKVDKLLERNVIEVAPLAFMRGRTLSDAFIIMDEAQNTTQEQMKMFVTRLGNNSKAVITGDLTQTDLPNPKKSGLLEALKVLDGVEGIKFCHFEDVDVVRHHLVQRIVRAYDTYGRAQLPLPIGDAGVADVSALGVVTPSTMAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM3</accession>
    <name>E8WZM3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_2974</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581311.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2974"/>
    <dbReference type="EnsemblBacteria" id="ADW69997">
        <property type="protein sequence ID" value="ADW69997"/>
        <property type="gene ID" value="AciX9_2974"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2974"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594166_0_0_0"/>
    <dbReference type="OMA" id="PAIETGP"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="11">
        <location>
            <begin position="34"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="374"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="48701" checksum="050EF65C362942B8" modified="2011-04-05" version="1">MNSFESFLLGYLLNSLWQLPFLFAAAWLAALALRPFGPTVEHRVWAIALLLQSLLPALSLASFQWLTSLAPWFSQAGPTAPGQVSVTVGPGLAAGNVTLSTSLLTGIAVLYTLAIAFFLIRLIRRAGTVLHLRRTAVPTLLTPEAEAVWQQCCRHFNLITPNAPTVALSLTVLGPVTFGLRRPVVLFPSGMIPSLPLPQLEAVMAHECAHLYRKDFALNLLYEAASLLISFHPILWLTRERLIETREMSCDHLAAQLVGPTPYGQSLLRLASLLITGRSARAPHAIGILDANIFERRIMKLTEKTKPLAGTRRTLILAACTAFALATCGSALALRLNVATPTSTSTLNGKDSNQAGTAKIAGGVMAGNILTKSQPKYPEQAKKDHIQGAVLLHAIIGKDGTIENLTVISGPQELQTSALDAVRQWVYKPYLLNGEPTEVDTTITVNYSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP9</accession>
    <name>E8WZP9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581337.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3000"/>
    <dbReference type="EnsemblBacteria" id="ADW70023">
        <property type="protein sequence ID" value="ADW70023"/>
        <property type="gene ID" value="AciX9_3000"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3000"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155949_0_0_0"/>
    <dbReference type="OMA" id="AYWTRQW"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14655" checksum="9C9ABCA161106220" modified="2011-04-05" version="1">MANTQRVIARAYSAFNERDIDSALALMSETVSWPKASEGGRVVGKEEIREYWTRQWQEFDPHVEPVEVIDREDGKTEVRVHQLVKSLGGEVLADGEVWHVHMIVDGLIERMDLKENEAGAGAAPSAAFAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT5</accession>
    <name>E8WZT5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0676</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579074.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0676"/>
    <dbReference type="EnsemblBacteria" id="ADW67746">
        <property type="protein sequence ID" value="ADW67746"/>
        <property type="gene ID" value="AciX9_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0676"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="GNHAYSA"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="271" mass="27590" checksum="D806C7D2DB23CDE5" modified="2011-04-05" version="1">MSEMNGVVMSLAGKVALITGGSRGIGAATVRMFRAAGARVVFSYQAAQEQAEALVVECGGEEVCRAVRQALATPADGAALVAAAVEAFGRVDCLIVNHGIWPAHDQPIATMTDEQWRGTISINLDSVFGLVRAGVAAMQTQVRESGPGAPSSVKGHIVLIASTAAQRGEAFHADYAASKGALISLTKSLSSELAGQGILCNCVAPGWVGTEMSLAALSDPETSKKATALIPLGRIGSVEEIAGPVLFLCTPLAGFVSGEIFNVNGGAVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW0</accession>
    <name>E8WZW0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ordered locus">AciX9_0701</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579099.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0701"/>
    <dbReference type="EnsemblBacteria" id="ADW67771">
        <property type="protein sequence ID" value="ADW67771"/>
        <property type="gene ID" value="AciX9_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0701"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_9_1_0"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="9200" checksum="A4251EE938E900FB" modified="2011-04-05" version="1">MEDTATRIIHIIAKSKSLPPESIQPESNFDDLQIDSLDKINLTFEIEEAFNITIPDDSLSSLRTVQDVITGVQRLQAEKSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X016</accession>
    <name>E8X016_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1866</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580231.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1866"/>
    <dbReference type="EnsemblBacteria" id="ADW68912">
        <property type="protein sequence ID" value="ADW68912"/>
        <property type="gene ID" value="AciX9_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1866"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070021_0_0_0"/>
    <dbReference type="OMA" id="AEMTLHD"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="38113" checksum="5B418FF4F773FE4A" modified="2011-04-05" version="1">MNRRALDVVTMLSVVVIGRNEGERLRRCLDSIAAMERGAWSLEVIYVDSGSTDGSLALAASMGAKSVALTPERPTAALGRNAGWRAASGDIVLFLDGDTVLHPAFVQDSLPSFADSKIAVVWGHRREIHPEQSLYNRVLDLDWIYAPGFTPFCGGDALFRRDVLAEMNGFDETLIAGEEPELCRRILGAGSLILHVDHPMTGHDLAITRFSQYWRRATRAGHAFAEVADRFSRTAQPFWSEDVRRNRNRAFTLIGAALLTLLTAAVLRSVLPILIGVCLFVLLVLRTAYKARWKSTDRTALMLYGIHSHLQQLPIYWGQLQFRRNRRRGLRSDLVEYKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X022</accession>
    <name>E8X022_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1872</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580237.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1872"/>
    <dbReference type="EnsemblBacteria" id="ADW68918">
        <property type="protein sequence ID" value="ADW68918"/>
        <property type="gene ID" value="AciX9_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1872"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594214_0_0_0"/>
    <dbReference type="OMA" id="LINVENW"/>
    <dbReference type="OrthoDB" id="1223813at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="50932" checksum="64FD3B5757C8D900" modified="2011-04-05" version="1">MSIIILIPTAICLYAILRGSVQKAFLNVFIPIFMLFPIYFYWKVAFLPPIDVAEAVLLPIGIAMLATQMKSWRFTSMDVWLGFFIFSSAYSDYLHGKTTAGIFEFFSNICIALVPYMAGKLLIEQYGARVATVRRFVICLFAACLIAGYEYRMGANPFSLMWARFFPDELFAWKTQFRWGWGRVSGPYGQSELAGIVFFFGLVLTLWLGYNHLWERKFSRANWLPFNKGNIIAWFIAFTLLMTQARGPWLGALVAVPIALIGRAKNLRRAAILVAVIGLGFGSIVYTGLKSYANQPTTSDEQQTAQYRQQLLDNYVPTAKAGGAWGWGQDFPRAMGQDSVDNEYLFVALTQGWVGLLSLCLLSAETIVRLVIAIIRCKNKEDCYFALSLLGIFAGMLLTLFTVFLGNQPYEIFFLLCGWSQSLVMRKAEALPEVEIVDDQPRQRFRQIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X026</accession>
    <name>E8X026_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1876</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580241.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1876"/>
    <dbReference type="EnsemblBacteria" id="ADW68922">
        <property type="protein sequence ID" value="ADW68922"/>
        <property type="gene ID" value="AciX9_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1876"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_4_0"/>
    <dbReference type="OMA" id="CYELVAP"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16043" checksum="CD834216DA291EBD" modified="2011-04-05" version="1">MSDPGPLRLHHVGYSTKAIDVTAALYVARYGYTLITEIIHDPLQTAFVQFARLDGDSSYLEFVAPDGPGSKLTAALKRGGGLNHLCYSCGRLEDAIAELEATGMKLVSEPKPAVAFAGRRICWLVGEDPLGIELVERRDDRDLCVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X041</accession>
    <name>E8X041_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1891</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580256.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1891"/>
    <dbReference type="EnsemblBacteria" id="ADW68937">
        <property type="protein sequence ID" value="ADW68937"/>
        <property type="gene ID" value="AciX9_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1891"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_3_2_0"/>
    <dbReference type="OMA" id="LGDYPAG"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="32474" checksum="7BACF4667B02827E" modified="2011-04-05" version="1">MPVVSPASRSQSAPTRHTRRNFLLGSAAAAAGVALYSGEFARHHIDVTQRTFAIRNLPPAFNGFRFVQISDIHLEEFTEEFFLTQVVKRVNALAPDLVLITGDYVTNGIQSTRVSLAAAGRCGALLNALDCPQRFGILGNHDAVLDPFVVRDHLQNNGIPLLVNQFTRIERGGQHLWLGGLDDILSGHPNLDLVMPPSPDAPVIVMAHEPDYVDAIVKHPRGKLVDLVLSGHTHGGQIRLPGLRPFKAALPTMGEIYTEGHYNFGPMQLYVNRGLGTVGLPFRLNCPPEITVATLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X047</accession>
    <name>E8X047_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase (Ferredoxin)</fullName>
            <ecNumber evidence="16">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">AciX9_1897</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="16"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1897"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="ADW68943">
        <property type="protein sequence ID" value="ADW68943"/>
        <property type="gene ID" value="AciX9_1897"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1897"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_0"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="35"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW68943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1516" mass="160978" checksum="359C705EBE30AF1A" modified="2011-04-05" version="1">MGQFQVNAARQVGEMGKIAAGAASLLDSRFDIDSCGVGFVATIDGVASHTILKQALTALARLAHRGATAADGKSSDGVGLMTAVPRAMLLKAAGVELAAERLLGVGVMFIPNDETNAEAVLERCLASHDLHILCWRDVPIATEVLGSIALNAMPKIRQVLVVDALGKDSVPPRAADSMERRLYLSRKQFERAQENDEVTGYVCSLSTQTIVYKAMCSGTLMPEFYPDLKSEEYVTPFTIFHQRYATNTTPTWDRAQPARMLAHNGEINTVWGNRSRMAARDATLPVECKPVLTKGGTDSTSLDEAVELVAKNGRTISEAVRVLLPPAVDPRRFSTFLSYHSDCIEPWDGPAAIAFSDGRVVGAALDRNGLRPCRFAVTDEGLVVAGSEAGLVDLDPEKTVHSGRLGPGQMLVVDLIDHKLYENDELLQIFDSEATTYAQLIDPISFEPELSDVCLTAETLKPLQRGFGYTREDVKMILQPMAADGKDSVWSMGDDTPLAFLARSPRPVYAFFRQRFAQVTNPAIDPLREAVVVSLHTRLGPWSHMLDKNAPLHGVSLPSPFLALEQIDALRDGKHPHNEELPVAELACVFSPELTLLQALDAVCQQAIELVRNGAKILLLSDRSAHAAENGSDVKIPVPMAMATGAVHQALVAAGLRTLAGLAVEAGDVRDIHHAAILIGYGAGAVCPWLALETAKSFGAPEAAAAERKMLKSFDAGLAKIMSKMGISVVDSYRGAHLFDILGLHQSVVEHCFPGTPAPLSGIGFEELDRQLRVGWLPETVAPAAEDLPDYGWVRFRKSDTSEPHAWMPPNVKALQTVVGSTRAGVKPADAHAAFKIYTDDLLAREPAVLRDLLAIKPIGPEISVDEVEPSTSLYKRFVASAMSLGSLSPEAHQCITIAMNTLGGRSNTGEGGEDPEVYRVEAAVPVPTSGAAQGQGGTAVAERVSVAAATETPLLKNNRIKQVASGRFGVTAAYLAHADEIEIKVAQGAKPGEGGQLPGHKVSGLIARLRHAQPGVSLISPPPHHDIYSIEDLAQLIYDLKRVNPKAAVGVKLVSSRGVGTVAAGVAKAYADFIVIAGNTGGTGAAALSSIKYAGNPWELGLAEAQQVLIQNDMRGRVKLRTDGGLATARDVLVAALLGADEYAFGTAVLVAIGCDMARQCHLNTCPTGIATQKPELRAKFRGKPEHIVSFFEELADDLRKLLAHYGLRSIEEAIGRTDLLEQVRFDGSLDLEEMLAFAPQATRSWTGVRNNQPVDGPPLDESWVAPALAAIAEGKAYSVEAQIANCDRAVGARLAGEIALLRAQAETPVDVSLKLHGTAGQSFGAFLVEGMVLELDGQANDFVGKGLSGGEVVIKARGNAARNSGQHVILGNVALYGATGGKLFAAGRGGERFAVRNSGVTAVIEGVGDHGCEYMTGGEVVVLGRAGINFAAGMTGGLAWVYDEDGSFVSDGRFHPEFVTADGYGAVELESQAALRTLVETHAATAASGLAQAMLADWEATAGKFVRLSPKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X078</accession>
    <name>E8X078_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3039</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3039"/>
    <dbReference type="EnsemblBacteria" id="ADW70059">
        <property type="protein sequence ID" value="ADW70059"/>
        <property type="gene ID" value="AciX9_3039"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3039"/>
    <dbReference type="eggNOG" id="ENOG5034A99">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2617044_0_0_0"/>
    <dbReference type="OMA" id="WALRQER"/>
    <dbReference type="OrthoDB" id="1962657at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8937" checksum="639AE778FC2DB45F" modified="2011-04-05" version="1">MMFMTPTRWKHFAAMTLIGDGVMALIHPQKDALAWKKGPKPWQRLMGELHERPGLTRVIGAAQIAGGIWWALRQERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X089</accession>
    <name>E8X089_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ordered locus">AciX9_3050</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581384.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3050"/>
    <dbReference type="EnsemblBacteria" id="ADW70070">
        <property type="protein sequence ID" value="ADW70070"/>
        <property type="gene ID" value="AciX9_3050"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3050"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_0"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="46314" checksum="505710D388951F3A" modified="2011-04-05" version="1">MKKFFGTDGIRGVAGQAPLDATTVHAVGLALAKSLKAVTDAPRVLLGMDTRESCGEIAATLTAGLVTGGATVENAGVITTPAVAHLTHAHGFAAGVVISASHNPWQDNGIKLFGPDGYKLPDGTEMAIEAEIERQLESHTAAPVAADAPAVNDADRAEYMRFLLAAVPGLSLDNKRVVVDCANGAASSVAPQLFSDLGGTCLITHASPDGRNINLGCGALHPEVVAAEVVRHQASIGITFDGDADRALFADETGKVVNGDAVLLLAARDLHARGELKNATVVATTMSNMGLEAALGRSGIAMLRAPVGDKYVLEQMLATGATLGGEQSGHIIFAGRSTTGDGLLTALLVLDVIHRSGKTLAELTSDLKTFPQVIVNVKVREKRPLEEIATVANAIAEAEAALKGTGRVVIRYSGTEKLARVMIEAEDEGQMRKHADAIAGAIQAELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G0</accession>
    <name>E8X0G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0754</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0754"/>
    <dbReference type="EnsemblBacteria" id="ADW67824">
        <property type="protein sequence ID" value="ADW67824"/>
        <property type="gene ID" value="AciX9_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0754"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_2_5_0"/>
    <dbReference type="OMA" id="AWSISCE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="42805" checksum="7628EA768A173819" modified="2011-04-05" version="1">MSEAELKATPKELTAHRRALPALTGIRFFAAAYVVLFHSRLAAVMAARGWTAAGNFFLSGYLAVPLFFILSGFILAYTYNGQIRHKGDHQRYFEARFARIWPLYALSLLLASLVNLRVPSPGVMVATALMLQSWNPFNLEMAGSWNAVCWTLSCELLFYLCFPWLQTWLERGHRRLPLVLLAGSVLLCVGTNSGSRTLWYTAHGVYRFIPLAVVHVPEFLVGVGLGNYFLERQRLPESASSRFGQGWLTYISTLVILALLCRPASFWTSLVIPAFAVLVYGLAEERTLLSRVLSSRLMTLCGGMSYAMYLMQNVVKPWVAEGMNRLHIDSVSLRLAVNMAVLLALSYVLFTAVENPVRKLLRGMFARMEGRRDLRQPDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M0</accession>
    <name>E8X0M0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ordered locus">AciX9_1925</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1925"/>
    <dbReference type="EnsemblBacteria" id="ADW68971">
        <property type="protein sequence ID" value="ADW68971"/>
        <property type="gene ID" value="AciX9_1925"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1925"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_0"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22076" checksum="11351081320CA75D" modified="2011-04-05" version="1">MTQRFAEPMARLIDELRKLPGIGTKTAQRLAFHVLRSPGEDADALADAIREIKKHLRLCSVCNNITDVDPCHYCSNPVRSHRLICVVEEPTNIATVERTRSYNGVYHVLHGTLSPIGGVGPEQLRIRNLLTRLEDVDEVILATSPTIEGEATAGYIAGELRRVKSGVKVTRIATGVPAGSDIEYADEVTMTRAMEGRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M8</accession>
    <name>E8X0M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1933</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1933"/>
    <dbReference type="EnsemblBacteria" id="ADW68979">
        <property type="protein sequence ID" value="ADW68979"/>
        <property type="gene ID" value="AciX9_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1933"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688732_0_0_0"/>
    <dbReference type="OMA" id="DSQFNGH"/>
    <dbReference type="OrthoDB" id="1284513at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234048" evidence="1">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="41998" checksum="B06F2B4CBC75D1C7" modified="2011-04-05" version="1">MTGCVRMSVLMLALGSSLIGLHAAAQTAATAPHTRGDISGDWQGTLQVDHPLRLVARFAKADKGFTGKMYSIDQGGQGFSASAITVDASTVKFTIEVIGGTYEGTLSADGNSIAGNWLQGPNPVPLTLVRATKETAWEIPPVAPPPKLMAADADPSFEVATIKPNDTGATGMQGLTVNGRNFQTRASSLGDLISFAYEVQSKQIVGAPDWVYHDRYDIAAVPDVDGAPNPAQIRLMIKKLLKDRFKLTFHQDKKELSAYVLTVAKSGSKVKETELQGSLPGINIRPSPKGLTLIIRNGQIADFTGFLQILVLDRPVVDHTALPAKYDFSVTFTPDDSQFNGHPPPLPAKTDAAESAPNLFEAMQQQLGWKLEAEKTPVDVMAIDHVEKPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X2</accession>
    <name>E8X0X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3144</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3144"/>
    <dbReference type="EnsemblBacteria" id="ADW70156">
        <property type="protein sequence ID" value="ADW70156"/>
        <property type="gene ID" value="AciX9_3144"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3144"/>
    <dbReference type="HOGENOM" id="CLU_3200394_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="45" mass="5014" checksum="2C9962B5EAFD2527" modified="2011-04-05" version="1">MLNPESSENEVMFRSFKDALPSRREMIVGAVAAVVGLRYAKGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y0</accession>
    <name>E8X0Y0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3152</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581477.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3152"/>
    <dbReference type="EnsemblBacteria" id="ADW70164">
        <property type="protein sequence ID" value="ADW70164"/>
        <property type="gene ID" value="AciX9_3152"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3152"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_6_0_0"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="22273" checksum="0EFB5B5B19DBB372" modified="2011-04-05" version="1">MTAENGRSTEYPIDPMFLDRWSPRSFTGEAIAEAELLTMLDAARWAASCYNIQPWRFIYALRDTPAWAKHLDLLVTFNQLWAKDASALVFFVSNSIMRMPGAETDSPSVTHSFDAGTASGYMALQARKLGWFAHGMGGIDRERAMTELNVPQGFKVEAAYAIGRLSDPEKLPEGLRKLEHPNDRLPLEQIAFEGEFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X177</accession>
    <name>E8X177_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1985</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580350.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1985"/>
    <dbReference type="EnsemblBacteria" id="ADW69031">
        <property type="protein sequence ID" value="ADW69031"/>
        <property type="gene ID" value="AciX9_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1985"/>
    <dbReference type="HOGENOM" id="CLU_1155143_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26824" checksum="16BF50B019578D73" modified="2011-04-05" version="1">MVIHYITEAVWPSIEVSIDHFAGSRPGNGPTKLTAGINFQIILGAACYLEGILESILRALLEHRRKIFFDSEQLDFAKRKSNNQFFNRLHTDLAARVGRSTGIAGYRETFELVTGYSFDDLSGLKPLLEALSVLFHFRNVLGHGREVAAKRVSRGNSALEDDFGGSYRKVEDYLFKKKLLKHRFVDRHSEYLFLGSDIADHFWGLAKKTPIALVGSLPTVEADVCSKALEIIRLAASPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X180</accession>
    <name>E8X180_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1988</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69034">
        <property type="protein sequence ID" value="ADW69034"/>
        <property type="gene ID" value="AciX9_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1988"/>
    <dbReference type="HOGENOM" id="CLU_1684088_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="16811" checksum="8E82A28F8EA534AC" modified="2011-04-05" version="1">MSLTPVTPSLPIPNPCPSCLRAFLTARDTCSSCKLVMCADCGCSCDHVSPAIAVAVATQKLWRTPLLPSQTLVVESEHDSCYGVSGETKWLSRLPLHEHEIAKCLPDGMGPIHQGHQRAALGSGEAQYSANGYGVDLLLFRIEGRRFTTSVFTPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K6</accession>
    <name>E8X1K6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">AciX9_3230</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581553.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3230"/>
    <dbReference type="EnsemblBacteria" id="ADW70241">
        <property type="protein sequence ID" value="ADW70241"/>
        <property type="gene ID" value="AciX9_3230"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3230"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_0"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="85"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="120"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="345" mass="36172" checksum="7A12BFA33AD66129" modified="2011-04-05" version="1">MAETQNVLFSSLKRVLETREALTRDEAARVLDYILDVDDFGSELRVAALLGALAARGETEEELAGFVDALRARATTIPLNDDERERLVDTCGTGGDLSGSFNISTAAGLVAAAAGVWIAKHGNRAVTSRCGSADVLEAMGIPVDQSPESAAQALRTHGFAFLPAPSLQPAMKAVMPIRRAIGVRTAFNILGPMTNPAGARAQVLGVYAERLVPVVARTLARLETRHAFVVHGAGMDEFTVCGPTAVGEVRDGEVWYSTVLPDDFGLKLAPIAMLAGGDAETNAGILQAVFAGEKSARRDVVVMNAAAVLVTAGMAQGMKDGVKLAQATIDDGKVTRLVYALAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P3</accession>
    <name>E8X1P3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rodA</name>
        <name evidence="7" type="ordered locus">AciX9_0894</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579286.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0894"/>
    <dbReference type="EnsemblBacteria" id="ADW67962">
        <property type="protein sequence ID" value="ADW67962"/>
        <property type="gene ID" value="AciX9_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0894"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_0"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="40014" checksum="AA01DF7267941691" modified="2011-04-05" version="1">MQRFSSFRDFDWTLLSLIGVLSVMSVLEIKSATLMTKFRGFDHKQILFLLGGMALMFVISLVDYHRLLDIAPWAYGVGFVALVAVKVVGTKVLGARRWIKLPGGIHFQPSEWVKLILILTVARFFWARAGRDLTWTDIFKVFALVGVPLLLVLSQPDLGTSLTYVPVLVIGLFLGGISWKQAGILILAFLLVGGAVVKSGKVLKPYQVARLTSFMDPDNDPKGSGYQIRQSKIAVGSGGIWGKGTNRGTQTQGDFLPIPYTDFIFAALSEEHGFIGAVVVLLLYFLILMRLIQNAQTASDLPGTFIVMGVVAVLVFQIAVNVGMVVGLMPVTGIPLPLLSYGGSSVLFTFLALGIVMNIRMRRFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P9</accession>
    <name>E8X1P9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0901</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0901"/>
    <dbReference type="EnsemblBacteria" id="ADW67968">
        <property type="protein sequence ID" value="ADW67968"/>
        <property type="gene ID" value="AciX9_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0901"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012856_4_0_0"/>
    <dbReference type="OMA" id="WYSLRNC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="500" mass="57838" checksum="8B1ABD2E06A9D193" modified="2011-04-05" version="1">MIILAFYGIHRYQLVWLYFKNKKNAAKWREPVARFDEANLPFVTIQLPSYNEQFVIERLIQACCKLDYPRDRFEIQLLDDSTDETVEVAREIVERYAAGFEGMPPQPIFYVHRTNRYGFKAGALDEGLRTARGEFVAIFDADFVPPPMWVMQVIHHFAEPEIGMVQTRWTHLNRNYSFLTQVEAILLDGHFVLEHGGRSRAGVFFNFNGTAGMWRTKVIAEAGGWQHDTLTEDTDLSYRAQMIGWKFKYLQDVECPAELPIEMTAFKTQQARWAKGLIQTGKKILPRVMKSDAPFHTKLEAWYHLTANLSYPLMIVLSTLLMPAMIIRSYQGWVQMMLIDFPLFMASTMSVSSFYLVSQKELFPRRWTRTFLYLPCLMGLGVGLTITNTKAVLEALFGVQSAFARTPKAGIRKKGEKSQAHKYRKRLGIVPWIELLIGCYFAFTIWYAITSENYFTVPFLVLFVFGYWYTGLLSLLQGRFDWLGPRSQGETHEKPYPVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X4</accession>
    <name>E8X1X4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2091</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2091"/>
    <dbReference type="EnsemblBacteria" id="ADW69135">
        <property type="protein sequence ID" value="ADW69135"/>
        <property type="gene ID" value="AciX9_2091"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2091"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_3_0_0"/>
    <dbReference type="OMA" id="KFALLEC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23086" checksum="9F5CE298AC97878C" modified="2011-04-05" version="1">MLFYVEFRYAGGMAGTITQVGTLDPRVRRTRLMLHDGLWSLLEKKEFDKISVQDIAEAAELNRATFYDHYSDKFALLECMVGSRFGELLERRGVRFSGCDGALRAIVLGVCDYITSVPGAACGGGRQLEGHMETAVIAVVRKMLLDGMKRHVRVEGEPAMAMSDAMVASAVSWAIYGACKEWLHTAGRCEAEEIVGKIEGLVVGMLRGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X217</accession>
    <name>E8X217_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3249</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581572.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3249"/>
    <dbReference type="EnsemblBacteria" id="ADW70260">
        <property type="protein sequence ID" value="ADW70260"/>
        <property type="gene ID" value="AciX9_3249"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3249"/>
    <dbReference type="HOGENOM" id="CLU_1641377_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17576" checksum="09B90CD1898C6CC4" modified="2011-04-05" version="1">MRLTSKILLLAVALVAVVLAVRHGGIAMQASLPKDMPENAHFLQSGYDVNTNEAKGNWIACRVDSEQGVNWCRVTDAHGMVVYEGNYLPVDSSSPVPESELKIVADSPSKLWVNGPVESSPVPVIKLANGRLLVPSADRGPLAERWKIDPSEYDQIMDRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X250</accession>
    <name>E8X250_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl-peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3282</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581605.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3282"/>
    <dbReference type="EnsemblBacteria" id="ADW70293">
        <property type="protein sequence ID" value="ADW70293"/>
        <property type="gene ID" value="AciX9_3282"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3282"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677749_0_0_0"/>
    <dbReference type="OMA" id="YDPIGEG"/>
    <dbReference type="OrthoDB" id="897879at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230584" evidence="1">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="162"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="434" mass="47013" checksum="1E4D93B86D7101FF" modified="2011-04-05" version="1">MKKLMVGMLVAALCVGFMGASESPEANFKVWRLEIRKALYVPDKLPALEAKTWSTFPVMPGVVADRVTYQTADGMLVPAVVYRPERWDVKVKGKLPGIVVVNGHGGDKFTWYAMYSGMMFAKAGAVVATYDPIGEGERNVERKSHAGAHDKIQAAPAGVDADKFHQDWGQRLAGLMQVDEMQGVAYLASRPEVDAKRIATVGYSMGAFVSGITGAIDPAIHAVVLSGGGTFDDEADGGKSFDTSALPCQGPPWHALRVLGDGPDERGAKLYALNAARGPMFVVNGSLDTVMDIPHRGPDWFVQIRAKAVALGGPEKTMFTTHVDAGMSHRTAWVERPAVEWLNEQIRFGSWTAAEIAAMPTTHVSEWITAGNVDISKGYIREDREGGLQALGTGFPGLQRPQLTVLPDADWERLKGRLTYEAWAEKTMKVAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X282</accession>
    <name>E8X282_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579338.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0947"/>
    <dbReference type="EnsemblBacteria" id="ADW68014">
        <property type="protein sequence ID" value="ADW68014"/>
        <property type="gene ID" value="AciX9_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0947"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239641_0_0_0"/>
    <dbReference type="OMA" id="WTAVLMD"/>
    <dbReference type="OrthoDB" id="1863431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="264" mass="28428" checksum="2C35AF46AC05703C" modified="2011-04-05" version="1">MRISINLASKPFVELRPLFAKIRLAMAVLAVLAIGFTLWLNVLTARAKAATAQMDRVKASTADFQNERARNEARMKQPQNKAVLDRSLFLNQLFANKSFSWTATMMDLERVLPEGVQVTSIEPVISKEGDVNIRLRVSGDRDRAIQLVRNLETSQRFLGPRLAGESALTADKAKALGGLQNVSAAAGGTPIGSGVEFEIFSGYNPLQAPKPASPKSSKSLAQSVAQDQSLPPAPTVVHNRHPKKPSADEPTVPGAAATPKGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X291</accession>
    <name>E8X291_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0956"/>
    <dbReference type="EnsemblBacteria" id="ADW68023">
        <property type="protein sequence ID" value="ADW68023"/>
        <property type="gene ID" value="AciX9_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0956"/>
    <dbReference type="eggNOG" id="ENOG5033IUP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3007917_0_0_0"/>
    <dbReference type="OMA" id="CEQYIAG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="56" mass="6728" checksum="1B2C57FBEB596AF0" modified="2011-04-05" version="1">MTDTMWKCDQLRAGQLYNRMMFDNEAEAEQFAFKMRQMEPDQTISIEAIEASQFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B4</accession>
    <name>E8X2B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0979</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0979"/>
    <dbReference type="EnsemblBacteria" id="ADW68046">
        <property type="protein sequence ID" value="ADW68046"/>
        <property type="gene ID" value="AciX9_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0979"/>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122734_2_0_0"/>
    <dbReference type="OMA" id="KEPVREW"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="13585" checksum="71D5E92BB1A079C4" modified="2011-04-05" version="1">MKRMDVVFFRTAAGGEPVREWLRNLEPVEDRKRIGMDIQTVEFGWPVGMPTCRALKDGLYEVRTNLTHGRIARVLFYIDSRERMVLLHGFIKKTQKTPDEDMDLARKNKRLHQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E5</accession>
    <name>E8X2E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579400.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1013"/>
    <dbReference type="EnsemblBacteria" id="ADW68077">
        <property type="protein sequence ID" value="ADW68077"/>
        <property type="gene ID" value="AciX9_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1013"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093424_0_0_0"/>
    <dbReference type="OMA" id="ESDCLVM"/>
    <dbReference type="OrthoDB" id="1238527at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011111">
        <property type="entry name" value="Plasmid_RepB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07506">
        <property type="entry name" value="RepB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="31536" checksum="434111D3D411F408" modified="2011-04-05" version="1">MKISEVPTVPIAEIRIINPRVRSRMTFDQIVASIATLGLKNPITVSNRHLDADGTRYDLVCGQGRIEAFLALGRVSIPALIVDVSREEQFLMSLAENIARRAPSDLGLLKETRSLLERGYGLEEIALKLGLSRQYVATIMVLLKNGEAKLISLVESGKIPITVATQIATGTSADVQQALTEAYATGDLRGPELRAARLLIKKRQAGQRPGGPNRKPKVPLTSQAAAKEYREQTQIQRNLIKRASIVRERLALAAAACTQLFADENFQTLLRAEGLTFLSDKLLDKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R2</accession>
    <name>E8X2R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3351</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581671.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70359">
        <property type="protein sequence ID" value="ADW70359"/>
        <property type="gene ID" value="AciX9_3351"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3351"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_2_1_0"/>
    <dbReference type="OMA" id="PLYMAED"/>
    <dbReference type="OrthoDB" id="1427241at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="37393" checksum="6CC763FD31E6B358" modified="2011-04-05" version="1">MKNIGFLSFGHWNPSPQSATRSAADVLLQSIDLAVEAERLGMDGAYFRVHHFARQLASPFPLLAAVGARTKKIEIGTGVIDMRYENPHYMAEDAGSADLIAGSRLQLGISRGSPEQVIEGWRHFGHDLAPGEDDAAMGRRHTEMFLELLGGKGFAQPNPRPMFANPPGLLRLEPHSETLRDRIWWGSATNATAVWAAKLGMNLQSSTLKFDETGEPLHIQQAAQIRAFRASWKEAGHTRTPRVSVSRSIFALMNDQDRAYFGRSGQETDQIGFIDGATRAVFGRDYAAEPEVLIQQLKNDQAIAEADTLLLTVPNQLGVAYNVHVMEAILKTVAPALGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S7</accession>
    <name>E8X2S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane assembly lipoprotein YfiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3366</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3366"/>
    <dbReference type="EnsemblBacteria" id="ADW70374">
        <property type="protein sequence ID" value="ADW70374"/>
        <property type="gene ID" value="AciX9_3366"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3366"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446731_0_0_0"/>
    <dbReference type="OMA" id="VHAQEEY"/>
    <dbReference type="OrthoDB" id="1281042at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234305" evidence="2">
        <location>
            <begin position="34"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="130"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="601" mass="63802" checksum="AC247082E6C0B04D" modified="2011-04-05" version="1">MILKPVRTFFPSRLAFVLAAAAFGTLGATAAHAQVTSPGPDQNPGGAVPQAATQQGVPAGTPVGAQAPAAGDNIPTATISNQPPSAFHRGKKKADPAVKDTKTVQSKDTKKNVKKNTKADALIGVDSKLPDKQLYDKAYAAIQKGHYDVARLDLQTMLNTYPDSQYQMRAKLAIADSWYKEGGTAALTQAESEYADFRVFFPNAPEAAEAQMRIGDIYFRQMDRPDRDHAKSIHAEEEYRRMLTDYPDSTLVPQAKQRLRDVQEVLATRDADIAAFYATRENWAAVIARYQTVVDTYPLYSHMDDALIGLGDAYEAQARYIRTLKLAEGPKQKLEKTYDDQAIAAYSKVVLEHSAAPHVEDARDRLAAMNVPIPEPTKDQLAASAAMENSRNSYRLADRARLLIMHAPDTVTSARMGEPTMADPHATTAPEVTKSVVANFNAALNPNAAKPADATATAAAQPDAAAPATAAVPAKPLAFQDVTTGDAPANSGAVEMTPASSGTTSTGTSMGVEILNSSSPTGTAADPNNGLHAVRPADSTPLPPVESAAPTPGQVNEATNPQPAAQAAPADGKKPKAAYDKGDESSSKHKKKKGIAKINPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X3</accession>
    <name>E8X3X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease T2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3476</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581792.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3476"/>
    <dbReference type="EnsemblBacteria" id="ADW70481">
        <property type="protein sequence ID" value="ADW70481"/>
        <property type="gene ID" value="AciX9_3476"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3476"/>
    <dbReference type="eggNOG" id="COG3719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066598_1_0_0"/>
    <dbReference type="OMA" id="WHQWKKH"/>
    <dbReference type="OrthoDB" id="1693572at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="PTHR11240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="SSF55895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233636" evidence="3">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="23558" checksum="34499B2F79E0AAA1" modified="2011-04-05" version="1">MKTLTSLACLFASLLVIAAPANAQKKGKVGVFDFYLLNLSWSPEFCAIEATSPECKAKPGFIVHGLWPQNNNGSYPVSCSNAPGPKNYSQYLDISPDLTLLEHEWPKHGTCTGLGPDAFFQLERTDFHAFKVPAAFKNTKAVTMTPAAIQQQLQQANPTFPAGSILVSCSNKELTAVEACLAKDGVTPTVCKGLSECAEPSITILPQGSTSAVNKKPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y3</accession>
    <name>E8X3Y3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ordered locus">AciX9_3486</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581802.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3486"/>
    <dbReference type="EnsemblBacteria" id="ADW70491">
        <property type="protein sequence ID" value="ADW70491"/>
        <property type="gene ID" value="AciX9_3486"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3486"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_2_0"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="8766" checksum="4693F6D03C6775BB" modified="2011-04-05" version="1">MPKEAIHPSYNNINVKCACGNTFETRSTNKGDIVVEICAACHPFFTGKQKMIDTAGRVDRFRRKFAQSDAAKAAAATDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X420</accession>
    <name>E8X420_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3523</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581839.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3523"/>
    <dbReference type="EnsemblBacteria" id="ADW70528">
        <property type="protein sequence ID" value="ADW70528"/>
        <property type="gene ID" value="AciX9_3523"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3523"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473218_0_0_0"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234342" description="AhpC-TSA domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AhpC-TSA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="19299" checksum="732DB63FD352AEF9" modified="2011-04-05" version="1">MLRVALSFVLCLIVTAAFGQGALDRVAVPGARAVVLFFVASDCPVSNRTFPEMKRVRESFASQGVVVRYVYPNVGETAAGIRVHQREFDAGGVTLGDADGALVRLTHAKVTPEAVVLVRSGAGGWKTVYAGRVDDRFVHLGQERPAATEHFVEAAVRSVLAGRPVVADPGGLVGCSIVSRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X470</accession>
    <name>E8X470_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67130">
        <property type="protein sequence ID" value="ADW67130"/>
        <property type="gene ID" value="AciX9_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0039"/>
    <dbReference type="eggNOG" id="ENOG5033XNS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044954_0_0_0"/>
    <dbReference type="OMA" id="NERWYSE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29014" checksum="366B51C07C2997A7" modified="2011-04-05" version="1">MMGRFGIALLLVLGASVGILRGQGTAAPGAIGDAPLLPEYREAPLPPAYGGVQVRIPGIYVTPVVNAPFTAKVQIVSQEQLPDGTVRVRKTVNHIARQSSGRIYNERRQLVAPTFQGEPRLISAHIYDPSTRLNTYLNPVTHIAQEIRMKQAAVAPNYGTTRMGVGKNPLLKEEELGEQALGPVMLRGIRRSRTVPAAVSGTGKDVVVVDEYWYSAELEIYMIIKHNDPRTGEQIVAVSDVERGEPDGKQFVVPGNYKRVDETPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X476</accession>
    <name>E8X476_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0045</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578465.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0045"/>
    <dbReference type="EnsemblBacteria" id="ADW67136">
        <property type="protein sequence ID" value="ADW67136"/>
        <property type="gene ID" value="AciX9_0045"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0045"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_1_0"/>
    <dbReference type="OMA" id="ADFFDCK"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="217" mass="23966" checksum="694AC2399AB5CDF5" modified="2011-04-05" version="1">MAPKPKSRQAPQIDHDILTEDFAAQLDSGAVHDALAADTTLPPFVSPRGQSARLDRCLWRNVTLTAPNARGLRLYDTQIEGSDLANLDLTGGHLERVEITGTRLTGATFTEAQLKSVLFRECKLDLAFFRMARLQHCVFERCNLTDADLYNADLTGTIFKDCDLSRAELSHAKLIQADVRDCRLDGLRGTPADMAGLMISPDQAPQLITLFGVKVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E5</accession>
    <name>E8X4E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1209</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579595.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1209"/>
    <dbReference type="EnsemblBacteria" id="ADW68272">
        <property type="protein sequence ID" value="ADW68272"/>
        <property type="gene ID" value="AciX9_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1209"/>
    <dbReference type="eggNOG" id="COG4640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="WTSNGAS"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1271" mass="133663" checksum="5A92B4BF708E6275" modified="2011-04-05" version="1">MFSLFKAPSLVRRIGQPGPLHLSSKAALLTLLLTPAISLVAQTGGEAGIQGTVLDQTGAVIPGAVVTATNTASGVTTTRTASSDGLYTISPILPGVYTVTVAAKGFQQAKQNNLNVDALKLTGLNVTLQIGDQNTEVTVESAPPALETTNATLGAVMENQTYSNLPLQQSGQQRDPTAFAVLTPGVVGGARAPIIGGTGNYLAAVYIDGIPVTTINQNGDNRVVSNALPVESIDQFQVITSSPDAEYQGAGLINFSLKSGTDKYHGSLATYVRARAFDAWSYASKDATCPTTSGAIVQCGKPDEHQSEYVASGGGHIPLTKKRGFFYLTYDKYHGRAGINPNFLTIPTARMRTGDFGELTTPIYNPLTDATCVGTTCRTQFTGNVIPTQYLSPTALKMQAALPTNYANTSTVNNYFGGVPSGFDNWEIAGRADFDLTSKQRLSYVIAYGVRKNVPFTVGTNATAAGVVLPLPYTAGGIATITPVITDIEHAWQISDHITNQLKFAFNRFGQPITSLTDGVVGDRAAADFGITGLPAGQAQTEFPGVAFTANTGNPTALASWTSNGASGATQTTVPNTYTLLDNFLVTKGKHSFTIGFTTQWLQDNVAAQLGPSSIYQLAFSANSTAPIVNGTISTTSAGFSYASFLLGAASQNTTLTEQAVSETGGRYHDISPYAEDVWKVTPKLTVNIGLRWDYFPPFHEVQDRWSFLNPNLQNAITGNMGELQFAGNHGGAGVSCGCRTPVNTWWKNYGPRVGLAYSVTPTTVVRAGYALVYSIGGGVGGRGGAGTGTGQTGFNIAAPSPTEITQTSAGAPGPSYYLNNGAFFTGAGIANTQYGGPGYALPTLPAQNATSQTLLTSYFGSTGSTGAGPGYADPYLSGRAPEFNMFNGGIQQALTKDLTLTVNYAGTQSHFLLGGGSNPRGYFADQLNPKYYVALAGVADSTGKNSLLGALATPANVQLAKNALPGYGLPYNAISSPTTKATIAQTLVAFPQYNGVSDTWGQNVANISYNSLQVSLAQRASHGLSYTFNYTWSRNIGDDGTYRSGFDLPSGSVSGTNAAYHQNRIDRGLTTTDMTHNISAYGVWEIPGAKSGNRLVRGVTSGFQISTIYQFTSGTPFIPTYSGCQSPNAGTCELDINPNYTGTGKLAKGYRSFGTQYIDPNAFSAPTTYSTGFATNYNKVGNAPRTAPFGLRNPYFWKDDISLRRSFNLGTSRLKFVAEVDALNVANHATLSNPTTTWGAPGTAAGSAFGKITGAQANPRDFQFAGHLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F4</accession>
    <name>E8X4F4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579604.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1218"/>
    <dbReference type="EnsemblBacteria" id="ADW68281">
        <property type="protein sequence ID" value="ADW68281"/>
        <property type="gene ID" value="AciX9_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1218"/>
    <dbReference type="eggNOG" id="ENOG50349PH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1852364_0_0_0"/>
    <dbReference type="OrthoDB" id="2198813at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="15446" checksum="9A67EB153CE4BE0F" modified="2011-04-05" version="1">MRGPRQRTSTIIGQPKHQMSHAWVKGSRLLLLVTALLVLVMPLTEYFWHFDKFLHGGQDFELSLLAVATSLCLALVLLQQRKKGIAIILAVRQWLSFLFQHGDLTKARTPARATSLIPVPTPPLALSALSLYNQPLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I0</accession>
    <name>E8X4I0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ordered locus">AciX9_2353</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2353"/>
    <dbReference type="EnsemblBacteria" id="ADW69390">
        <property type="protein sequence ID" value="ADW69390"/>
        <property type="gene ID" value="AciX9_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2353"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_0"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="141"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="373"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="440" mass="49496" checksum="A11D9EE873014AAD" modified="2011-04-05" version="1">MSKTFYIETFGCQMNAHDSEKVVGTLEQQGYAQVQDEAEAGLILYNTCSIRDKAEQKVFHRLNEYKKMQGEGKRFAVIGCVAQQEGEKIFDRAPYVSIVAGSASYRNLPGMLERLERGDQRITGLDDKKTTETFETPFVARTNQHRGYITIIEGCDKFCAYCVVPYTRGNERSRSAASVMEEARRMADSGYTEIQLLGQNVNSYRDPSGAKSFAELLHAVGTIPGIRRVRFTTSHPRDFTRDIVEVIDATPTLCDHVHLPVQSGSTRILAAMAREYTREWYLERIAWMKAAKRDISMTSDIIVGFPGETDEDLEDTATLLDAVGYDAIFAFKYSPRPNTPSVSMADSLSDEVKAARLQILLDRQREIQRINYQRHIGQVVEVMVEGHNRQRNQVVGRTSQNKTLNFTTAQPIMPALGSYQMVRITQAFPNSLLGEAQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K9</accession>
    <name>E8X4K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2382</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580735.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2382"/>
    <dbReference type="EnsemblBacteria" id="ADW69419">
        <property type="protein sequence ID" value="ADW69419"/>
        <property type="gene ID" value="AciX9_2382"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2382"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_6_6_0"/>
    <dbReference type="OMA" id="AVIQGEM"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="12268" checksum="DB318E25D12471CB" modified="2011-04-05" version="1">MKPAEGSTLIGKSVTIKGDLSGSEDLFMDGILEGTVTLTESRLTVGPNARVKADLQVRDLIVFGIVDGNINASGRMELRQSAVVNGDVIAARLSIEENATIKGRVELTGQSAKTPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P2</accession>
    <name>E8X4P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2415</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580768.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2415"/>
    <dbReference type="TCDB" id="1.A.77.3.42">
        <property type="family name" value="the mg(2+)/ca(2+) uniporter (mcu) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69452">
        <property type="protein sequence ID" value="ADW69452"/>
        <property type="gene ID" value="AciX9_2415"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2415"/>
    <dbReference type="eggNOG" id="ENOG503385I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884797_0_0_0"/>
    <dbReference type="OMA" id="GSGLWEW"/>
    <dbReference type="OrthoDB" id="1847192at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="14868" checksum="AB46A4A996CF2100" modified="2011-04-05" version="1">MDLASLGGFTDDDFKRTILSALRLLGVLSVIAMALFWWKSGWQSAALLVIGAAISGSGLWEWLRLMSAVMERMDAGGKARPMGLILFGFFLRLGLTVVILYVSLKYLNGSVLALAAGLGLGVFALTVEGLRLMKAWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T8</accession>
    <name>E8X4T8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ordered locus">AciX9_3573</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581888.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3573"/>
    <dbReference type="EnsemblBacteria" id="ADW70577">
        <property type="protein sequence ID" value="ADW70577"/>
        <property type="gene ID" value="AciX9_3573"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3573"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_0"/>
    <dbReference type="OMA" id="AQTWRFP"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="427" mass="44865" checksum="AE93F061B1DC8CD1" modified="2011-04-05" version="1">MRVMEKSRQLQVRAAGLLPGGVDSPVRAFRAVGGDPPFVKRAEGAYLWDVDGNKYLDFFGSWGPMILGHAFEPVVEAIKEAVGRGASFGASHADEANLAELVTRCFPSVQRLRFVSSGTEACMSAIRLARGFTGRKFVIKFEGCYHGHADALLVKAGSGIATLGIPGSAGVPEETAMHTLALPYNDLSAVETAFALHPGQIACVIVEPVVGNAGTIIPAEGYLAGLRRITQEHGALLILDEVMTGFRLSLGGAQELYDVKPDLTTLGKIIGGGLPCGAFGGRADVMEFLAPLGPVYQAGTLSGNPLAMAAGIATVGHLIANEAAVYSQLEHVTKAVAEGVVEIAAAAGVRLTMNRVGSMFTWFFTDQPVRNFADAATSDSAAFGNFHRGMMEAGVWLPPSQYEAAFIGTAHGEVEVEMALAAARKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U0</accession>
    <name>E8X4U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3575</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581890.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3575"/>
    <dbReference type="EnsemblBacteria" id="ADW70579">
        <property type="protein sequence ID" value="ADW70579"/>
        <property type="gene ID" value="AciX9_3575"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3575"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_1_0"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="11067" checksum="E0EE28CF75462730" modified="2011-04-05" version="1">MTKEDILGILRAHEAELKAAGLMHLRLFGSVARDENTAESDVDLLFDSDDSDLHNTLRAYGFEDDLSRILGVRAHLSSLTYMRPEIKHQVLPETIDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X531</accession>
    <name>E8X531_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEGA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0148</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578551.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0148"/>
    <dbReference type="EnsemblBacteria" id="ADW67223">
        <property type="protein sequence ID" value="ADW67223"/>
        <property type="gene ID" value="AciX9_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0148"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="AYDLTHA"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233688" evidence="1">
        <location>
            <begin position="32"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="588"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1285" mass="134980" checksum="B67A5547FAD85F53" modified="2011-04-05" version="1">MNASRTPRYRHALFFLLLCFALLFQGHFASAQNGGEGAITGTVSDPGGARIPTATITATNVGTGVVITRPASSSGLYQLSPLIVGTYTVTVSAPGFQGFTQENITINAAQVFGLNLTLKPGSQDESVTVTAAPPALDTTNATLGGTITSDEYMELPLLVAGNQQRDITQFSNLLPGAQPGARSSLFSGTASRVEEVFLDGIPISTISQIGDNRPIFNIIPSEAIDQIGATTSGQSVDAQGAGSVNYTMKSGANQYHGTVADFIRNTIFDTWGFTAPAVPSQRSVNGVIQSGPPVKPADHQNEFTAAAGGPVRIPFLFNGHDKLFFFGAYDLTHANSAPTYATATIPTLLMRTGDFTEVPYTIYDPTTLTCPTSTTCTRQPFTGVKNGLPTANVIPTNKLSPISQTMQSFLPAPTTSGIQNNYLGGYPQGNHNWLYSGRIDYDASTKQRISFVIAGGNTHPIPYTGNSSVLPVPYLASVYTQTGGHWADLEDIYTIKPNLVNQFKFGFANLGGKPSRNLTQDVAQYEAVNMGINFSGLPADSQAVTEFPTSTFSGSNAQTQWADGVPGTSKTTVDESYTTVDNLLWVKGRHAMTFGIQIQQLELNQSAQDGPTSGITLAWGVNETARINGTSYASSTGYAYASYLLGAVANTSVSVLPFSVLGGRYHPLAPYFQDNYKVTEKLTLNLGLRWDYLPTYNEVLDRFSFLNPNLTNPVTGNLGALQLAGNHGGAGVSCGCRSPASNYMKNWGPRVGLAYSVNDKTVIRAAYALVYSHGGGTGGAGGAYQGTGSLGLTSTPSFTDGGAGTGAGPAFYLNNSAGFQAQGLSNNNFGGPGYTVPAVTAPGPISQTLNVGNYVTSAGAYVSPGGISYLDPYVSGRSPEFSFWNFGFQRELMRDLTLMVNYAGSESHFLAGASNIRGLQSGQIDPRYYMLGTALLSAPATTANIAKASAIVPGIAAPYSGYSQAASTTSGAGKATIGQMLTWMPQFSSVTDTWGSQTANASYHSLQLSVAKRLSHGLTLNLNYTYGKQIDDTGTIRSGYAIPANLTLNGKAWAQDRIDRGLSATSVPQNLSIYGVYKLPAGGKGEFLGDHLLTRAILGGWNLSGIFTYVSGTPLAITSSACTSSSEPGAGQCMPDINPNFAGKTIRQNGSWGKGITAANLGAISYLSGAVTSTTPGQGVGGAACTSSSGPFCNSGSLMIGDAPRTAAFGLRNPSVYNLNMGVRRSFDLNERFKFIFAVDCQNVTNKVTFSGITTNINSSAFGTLSGATSNSGSRDFQFSGRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X534</accession>
    <name>E8X534_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578554.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67226">
        <property type="protein sequence ID" value="ADW67226"/>
        <property type="gene ID" value="AciX9_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0151"/>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109402_0_0_0"/>
    <dbReference type="OMA" id="ICVESTN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="50"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="21400" checksum="D144A3275C0D0B73" modified="2011-04-05" version="1">MTPSTTLRPARTHNYKYAWIPVLFGLAVICGESTKVMGGANTGQWLLHLVNLFHHQADTARFEETNVFLRKVGHFFGYGLLGVMFARAWTSFLRKRVLMTWSALRVRGVGCGVMSACLVACADEFHQSFLPGRTATIHDVVIDTTGALLLNTIVFAVAASRRRKLIEVVGNMRQTRLQRLRSRYGRGFGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X548</accession>
    <name>E8X548_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579635.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1250"/>
    <dbReference type="EnsemblBacteria" id="ADW68312">
        <property type="protein sequence ID" value="ADW68312"/>
        <property type="gene ID" value="AciX9_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1250"/>
    <dbReference type="HOGENOM" id="CLU_1259954_0_0_0"/>
    <dbReference type="OrthoDB" id="1767392at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="1">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="24830" checksum="9A0B1FBA9B302A36" modified="2011-04-05" version="1">MSSRKVEDLLREEYLDLLPELVRLADDLKARIEFHILPVARQLKTYENLIVKARIKDCSSAIDALKRRSQARLFDQEHPDLYSLKALRDLVGIRVLAFPSEQAAQVDTLLRDEFPEWTSDPVIDSQTGQQLASKYYGVDPHSPSALLCEYQIASTLTGLFWEVEHAAIYKSAPNLKAFINSPAMRERTSDVYSALKAFEGEFERQLKQADRSGKSVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C2</accession>
    <name>E8X5C2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chloramphenicol acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2433</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580785.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2433"/>
    <dbReference type="EnsemblBacteria" id="ADW69469">
        <property type="protein sequence ID" value="ADW69469"/>
        <property type="gene ID" value="AciX9_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2433"/>
    <dbReference type="eggNOG" id="COG4845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093121_0_0_0"/>
    <dbReference type="OMA" id="WNRKEHF"/>
    <dbReference type="OrthoDB" id="1533752at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008811">
        <property type="term" value="F:chloramphenicol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001707">
        <property type="entry name" value="Cmp_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38474">
        <property type="entry name" value="PTHR38474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00302">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01059">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="25009" checksum="78416C07755D30FE" modified="2011-04-05" version="1">MQHFENGSGQKIDLETWNRRATFQLFKDYSEPYHGVCLRVDCTATYRFARQNHISVFLSLVHRSLLAANQVENFRTRIVDGTAWHYDQINAGSAVGRANGTIGFGHYPFHPRMEDFVREGSVELERVRQREDLERYPDANLIRYSVLPWFDFTAISHAHDVSRKDSAPHITFGKITESNGRAAMPVSIHVHHALADGLHVAQFVEKFEQALADPAAEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D7</accession>
    <name>E8X5D7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Baseplate_J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580800.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2449"/>
    <dbReference type="EnsemblBacteria" id="ADW69484">
        <property type="protein sequence ID" value="ADW69484"/>
        <property type="gene ID" value="AciX9_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2449"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008328_0_0_0"/>
    <dbReference type="OMA" id="GCNARTW"/>
    <dbReference type="OrthoDB" id="195888at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="588"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="846" mass="89964" checksum="65966E9168517DC5" modified="2011-04-05" version="1">MIYTCCDARRRAVLAGQTAINAIDFLDVVNDPSMPAAQRQRTLNVHFLHPLTPDQIKPANIVISGGERITGIKVVSATVASELSPGGNPRILVVVVNTAGDFSPYQLQLVQPNDPTEPPAGFDPVLSAIEFSFKAACPNTLDCQPESACSPSAVAPPAISYLAKDYTSFRTLLLDRMATVIPAWTERHPADVGVMLVELLAYLGDNLSYQQDATYTESYLQTARRRTSVRRHVRLVDYPMSDGCNARTWIHFETGDGIAGVTVPAGTELLTAGSSPTTVLDVASQEYKQALAENPVIFETMEPVTVRTAHNRLPLYTWGDRECCLPAGSTGADLEGAYPDLQIGDVLLLVEEKGPLTGATADADPSHRYPVRLTAITQRIDPIGGQFDDPQTNAPTIVTHVDWGRDDALPAPLCVTNTVGGTFLSGISAAWGNIALADHGFTVRGEALPPVPAANPALTVQAPPADWCGTDSTAIVRPVRYNPTLAQSPLTFADPYSPASTSAGVPSAAQALQRQESLITAQITSLTQTDGGRPWSVQPTLLRSVGSANNFVAEVEDDGSASLRFGDGTFGSAPTTGTSFQATYRVGNGTAGNVGAGTLVRLATDTGSVLLGAGVILSVTNPLAGMGGEDPETLDEVRLRAPQAFRAQERAVTPEDYGTMAVRVDPLLQRGTGTLRWTGSWQTVFVSVDPQDSETLNDSRRAAIANGLELYRMAGQDVDVQPPVYVSLELKLSVCVQQGYQSAHVEAALRNVLSNCSLPDGSRGLFHPDNFTFGQTVYLSPIYAAVQDTPGVASVTVKRFARQGKATTDAVSAGKLTLGRLEIARLANDPDYPEHGQFTLHMKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G5</accession>
    <name>E8X5G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2479</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580828.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2479"/>
    <dbReference type="EnsemblBacteria" id="ADW69512">
        <property type="protein sequence ID" value="ADW69512"/>
        <property type="gene ID" value="AciX9_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2479"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767320_0_0_0"/>
    <dbReference type="OMA" id="HLGQINY"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="154" mass="16695" checksum="0515E1FABD5426F0" modified="2011-04-05" version="1">MGFSDELAGLYARDLARLRAQVELFPNDEAVWVVLPGVVNPAGTLVLHLEGNLREYVGRVLGGIAYVRDRPVEFSARGVSQRELAGRIAEVEGMIPGVVAGLSSEVMEGAYPGEGNGEVTSTQRFLTHMYGHLGWHLGQIDYLRRMLAGGESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I2</accession>
    <name>E8X5I2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2497</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2497"/>
    <dbReference type="EnsemblBacteria" id="ADW69529">
        <property type="protein sequence ID" value="ADW69529"/>
        <property type="gene ID" value="AciX9_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2497"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_1_0"/>
    <dbReference type="OMA" id="ATMTHKL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="28250" checksum="DCB96D10AC4FFF51" modified="2011-04-05" version="1">MEESITERNDRWAELEEALRQSRTLAAAGQFAAAVMHEINNPLEAITNLAYLAREEADDPEKVREYVSLLQEQLASVVQIAHQTLSFHRGAAALAAVDMGEITDAAVRVYQWKLAAKQIRLLKEIVPDAKVRAHAGELLQVMSNLVVNAIDALPEKGTLRLRVRRCEAQVHLTIADDGHGIPEPMLAKVFDPFFTTKADRGTGLGLAISKAIVERHQGTIRSRSSTRKGRSGTAFRISLPREIEAAERESAGSRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K6</accession>
    <name>E8X5K6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3630</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581944.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70633">
        <property type="protein sequence ID" value="ADW70633"/>
        <property type="gene ID" value="AciX9_3630"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3630"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136792_0_0_0"/>
    <dbReference type="OMA" id="YKHEVEV"/>
    <dbReference type="OrthoDB" id="1551397at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="27681" checksum="FD323CF9DDF9636E" modified="2011-04-05" version="1">MEAIGIKLRAARVQWQLTLREVEERSSRLATQWGNPAYRISASWLDRVERENRGLSATKLIVLASVYGLTAEQMLGLCPDSTVLPMQTEKVSSPNATLLLEEGALEQRAKLWLPDKLVTDAPPASTTLLPTEDGTIPTHYRRGIIGQLDRTLEPMIRAGSIVLIDTQKRAIAGRKEWNHEFDRPIYFLLTRTGYVSGFCELDKESEWLTLIPHALSFETNKRWRYRKEIEVVGTVAGVFSRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S9</accession>
    <name>E8X5S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
            <ecNumber evidence="3">6.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="6.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572725.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70813">
        <property type="protein sequence ID" value="ADW70813"/>
        <property type="gene ID" value="AciX9_4017"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4017"/>
    <dbReference type="HOGENOM" id="CLU_016684_6_2_0"/>
    <dbReference type="OMA" id="YYHLPKA"/>
    <dbReference type="OrthoDB" id="1068772at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="386"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="60055" checksum="1091B3895152763A" modified="2011-04-05" version="1">MRPAPYPFAAIVGQQQMKLALLLAAVDWRLGVLLRGDKGSGKTTTARALAALLLSPAPFINLPIGATEDRLLGGLHLERALQGDPILKPGLLSQAHGGVLYVDEINLLPAHLGDALLDAAASGIHTIEREGLSASHPAEFVLLGSMNPEEGTLRPQLLDRFALSVDISAPTDPLTRQQVVEQRLTYERNPQAFAQNWSAEQSHLQSQITTARRTLPTILCPPEILALITQTIAAQNIRSLRADLATVRAAIALAALTASPEVTPEHVETVLPLVLAHRTRTPNRTPPPQQPPTPPPPPQSEKDSPTQEAIDRIFTPHQVEAPTLRLTQPAQPPQTTGPVTSTRATPTPTELDLRTTLTHALRETGTPTPRLSDLHEKIRTPRPGTRFLLVIDSSGSHAAQERMRLVKGAVTALLTRSFQRNDEAAIILFRGTAAQILLEPTQTLADAIAALEYLPTGGRTPLAHALTLAQTLITPTTLLILLTDGRANVPINNGDPWQEALAAAHHITCPTLIIDTEPPQNATGQTRTLAESINARYITLEDLPTLETLTLSHSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X1</accession>
    <name>E8X5X1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70855">
        <property type="protein sequence ID" value="ADW70855"/>
        <property type="gene ID" value="AciX9_4071"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4071"/>
    <dbReference type="HOGENOM" id="CLU_3310497_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="39" mass="4566" checksum="50A46B2BC3FE1E11" modified="2011-04-05" version="1">MRKPCLKQAYRKSTRSAESQSSATNFFRIFRERSLEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y8</accession>
    <name>E8X5Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4092</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572784.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70872">
        <property type="protein sequence ID" value="ADW70872"/>
        <property type="gene ID" value="AciX9_4092"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4092"/>
    <dbReference type="HOGENOM" id="CLU_1052769_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="264" mass="28991" checksum="118122B4483319E9" modified="2011-04-05" version="1">MIVPTNPEERIDLVLDYLLDELPQSQIEAMDNALFESEDLASVFAEYKVDLIDAYADGRLSPTQHQRFERMLLIDLNLRALTPFAHALSSMRAHAAEAPHQRPKSQARSKLAYGAAALIAIAATLIAVIFTHRPHPVPASNPQPPTVIAANNPPRQGSIYPVILSPAILRGHADSDVHIPASADQVRLQILLPAESDKLQYTASLRGKSHSFQSTFYNLRPIQAGVERYIEVTIPSGDLQPGAYELSVSDQSGLPVHKYPLKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X614</accession>
    <name>E8X614_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572810.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70898">
        <property type="protein sequence ID" value="ADW70898"/>
        <property type="gene ID" value="AciX9_4118"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4118"/>
    <dbReference type="HOGENOM" id="CLU_024437_2_2_0"/>
    <dbReference type="OMA" id="NDANTRQ"/>
    <dbReference type="OrthoDB" id="1788350at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="30169" checksum="1FB42C619D4DDE00" modified="2011-04-05" version="1">MRFVPNIASNVITDIQASDQNVQTALQQVSSGLRVSLPSDDPAASAALVQLQAQSANIDQYTTNASSALSQAQSADSVVSSVVSLLNRAITLGTEGANSTSSTANRASIATEVQGLLSNVVSLANTSFQGISLFGGTVSGQAAFTADSTSATGYKYNGNSGVNSVSVGDSLSVQANIPGNTLFDNSSASVLGALSGLATALTSGSSTDIGTATTAVTTALNYVTQQHVVYGNTINQLNAQETYLASDKVTLSSRETSLVGIDTATAAENLTQAETSNTAILSASARVLQNNLLTYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C4</accession>
    <name>E8X6C4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4232</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71008">
        <property type="protein sequence ID" value="ADW71008"/>
        <property type="gene ID" value="AciX9_4232"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4232"/>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="425" mass="46859" checksum="99D639FB43775DEA" modified="2011-04-05" version="1">MVESGRAVTKLAVEPEPMNAKDREDIDRQVERILEHPLFHQSKRLPIFLRYIVDTSLAQGGQGSTKERTVGIEVFGRKPDYDNNSDPIVRVTATELRKKLAQYYYEDGHSDEIRIELPPGSYLPRFRRSVREDAAAADQAEQPQADLAEAVTPAGETPVEAVQELPEGTGRQRLSGLRWPLVAGTLGVLLVGVTGALIQRMWKQSHTPQDQFWSGLMANSERALIVMPVIGSDNIKDAETQRRSVSVSPNLSLEDTDIGARIASQIDRQGRRFQFVSSSEVALDQLQTEPAILIGALDNAWTIRLMRDLPFVFEEAPDHRTGRILDSSSGGAKSWTVDIDMPHKRIAHDYGIVARFTSRLTGEPVVVVAGISSQGTQAAGKLLTSPEFESIRAIAQGNANFEVIIETEAVDGHGARPQIVVSKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J8</accession>
    <name>E8X6J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3865</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582169.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71148">
        <property type="protein sequence ID" value="ADW71148"/>
        <property type="gene ID" value="AciX9_3865"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3865"/>
    <dbReference type="HOGENOM" id="CLU_009583_35_0_0"/>
    <dbReference type="OMA" id="PAVRHGC"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="45441" checksum="D1721A5CC5913F3A" modified="2011-04-05" version="1">MRIVILNDFAHVEGGASQVALSSARALAGRGHQVMLFAGVGPVSPDLEGIEYLEVVCLGQQDILADLNRGRALIRGLWNDSSGSAFREAMRRFDPADTVVHLHTYTKSLSSSVVRAALDCGFRMVLTMHDYFSVCPNGSFFIYPTQTLCPHTPMSAACLGTQCDTRRYAHKLWRVARQWTQEHRGRLPSGLHEFISISDVSERILRTYLPAGARVHRVPNPIAVPHEPPAHPDEHATFSFVGRLSAEKGPQLLAACAAKHNLPVRFIGEGAERAKLLEMLPEAEFTGWLNGVETRKALRASRALVFPSLWYETQGLVVVEAAAQGLPTVVPSESAAREWVEDGLTGLIFRHGDAEDLAEKLLFLRDHPDSAAAMGTAAYQRYWQKPATMEAHCERLEAVYVRMLEQGNGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V1</accession>
    <name>E8X6V1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3977</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71251">
        <property type="protein sequence ID" value="ADW71251"/>
        <property type="gene ID" value="AciX9_3977"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3977"/>
    <dbReference type="HOGENOM" id="CLU_023620_4_1_0"/>
    <dbReference type="OMA" id="MHVHVWD"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="158"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="555" mass="60068" checksum="C79E8136ABF3AE50" modified="2011-04-05" version="1">METPFHHLSMLLQASRGGFEVVAFDYQPKQSPRFSAVMVRGRDTSSPGFIQNSTEQCRCSRRIRLSLLTSVPEDLMNLRSLTLALTSPALAWTVAFGQPTPPPPLAIEHVTVLPMTAGGTVLHDQTVTLRDGRITAIEASTATKPASGVRRIDGTGKYLMPSLADAHVHLENDRFLRLFLDNPKIPAGTIRTEDIFLPYVANGVLQVIDLSATSETVGQRDEVENGRVLGPHIALAAMIDGKDPILPVGMTRVAATPSDGRQAVRDASVEGYELIKVYSTLDLPTFTAIVDEAHKLHMPVVGHIPQRGKGTTDKFFQPGFGMVAHAEEFAQQTDVPVEADIPGYVEMAKRNGTWLTGTLSLDERIVEEASHPESLQARPELQFLSPPIYTYVTAHNPYVANANAKFIDYVRSIVAFNRKLIQAFAAAGIPVLAGTDTPVPGMVAGFALHDELEAMARYGLSNQQVLEGATRLPAEWLGVAGDRGVVAPGKRADLLLLDADPMADVANTRRITAVIAGGRFLSRTDLDQQMAALAKRYAKMRAADTVPTGKPHALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X723</accession>
    <name>E8X723_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3846</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582154.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71132">
        <property type="protein sequence ID" value="ADW71132"/>
        <property type="gene ID" value="AciX9_3846"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3846"/>
    <dbReference type="HOGENOM" id="CLU_032719_1_0_0"/>
    <dbReference type="OMA" id="VFMLAEW"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233763" evidence="2">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="59"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="54959" checksum="A855F9DF2DAE8655" modified="2011-04-05" version="1">MTASALRRSLLLTALCLCASLPASLAQMPAVPTTPSTTPLGATQGHIPPPWLESAVVYEIFPRSFSPEGNLAGVTKGLDRLQKLGVNVLWLMPLNPVGQVKKKGSSGSPYAVQDYYAINPEYGSKDDLHHLIQEAHRRQMKVIVDIVANHTSFDSVMMSHPNFYKHDSTGKILSPYDWTDVAALDYTQPELRRYMTDMLLYWIKDFDLDGFRCDAAGEIPTDFWENARKELDRVHPGLIMLAEASKPELLRSAFDFDYSWPMMASLNEIIEHGAPASTLRTTLEHEQKLFPQNAAHMRMFDDHDEQRALARYGINGSLAAAAFIFTYDGVPMLYNGMEVSDPTESGAPALFEPLKIWWQAGEMRPEFPRFYDFMIHYRERQPALLHGKTSWLHNSNEAHVVSYKRSTPNEEFLIAINLSSTPFRGTIESSAPWTEVSIPLRKPPSNTGEPDEHHPDYPEAALPALSLEPFGFRIFHRSLTPVAKTASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X754</accession>
    <name>E8X754_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4335</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71288">
        <property type="protein sequence ID" value="ADW71288"/>
        <property type="gene ID" value="AciX9_4335"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4335"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_3_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="486" mass="51941" checksum="EE43ACA1F1F7CC67" modified="2011-04-05" version="1">MTDTMNKARLSEDREIETDLPQRMDRLPWSSWHVRIITALGTSWLLDGLEVTLVGSLSGILESKQGLSLSDPQVTAAATTYLAGAVIGALLFGHLTDRLGRKKLFLVTLATYSVATVCTAFSHGFLFFAVCRFFTGLGIGGEYAAINSAVDELIPGKVRGTVDLFVNGTFWVGASVGSVTALVLLGGSLFPQATSWRYAFGIGGGLGLLVLLLRLAVPESPRWLMLRGREEEAETIVRDVEQRVTTSSGKALTRPEGEKLKITFRDHTPWKEIFVNMLGENRQRSFLGLALMIAQSFFFNAVFFTYALVGKRFFHVPDQKLPLQLLPFAIASFLGPFVLGPLFDRIGRKPMITATYAVAGILLGAICLPFATGSLGLRGLGICFSIIFFVASSAASAAYLTVSEIFPLEIRAFAIALFYAIGTCIGGVGAPLLFGVLIHTGSKPAVAAGYALGAALMVGAAVLEAIIGVEAAGKSLESVSKPLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B1</accession>
    <name>E8X7B1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4394</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573064.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71345">
        <property type="protein sequence ID" value="ADW71345"/>
        <property type="gene ID" value="AciX9_4394"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4394"/>
    <dbReference type="HOGENOM" id="CLU_041029_0_0_0"/>
    <dbReference type="OMA" id="HRPECAW"/>
    <dbReference type="OrthoDB" id="658705at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="502" mass="55139" checksum="5FD6DD32B4D7640B" modified="2011-04-05" version="1">MGYAAIYIPEFPTLAWLRLEKRARVQAVAVVEGKAPLERVVSFNRSAKDLGLTHGMSKVQADTSGQVLFHERSIAEEKAALEILFEAVERFSPRVQIIASPVNGYANGKQSAAVLLVDQSGTETLFGDARSYAEAIRSALQQLDFASNVAVAPNAEASLLLARSYSGVTQVDAKDVRSKLAPLPLSMLTVEAATLATLGRWGIRNLGELAALPEAALVSRIGQQGKRLQRLAVGCEDHLLVPQDPSFVLTEHVELDGPLESLEPLLFILSPMIETLLRQTINHAYALRSVTITLELEKASPHRLEVRPAVPVQSKDLLLKLLHLKLQADPPQAGILGLTLDAEPAIPQVAQRGLFQSQFPEPDKLDLLVARLKAVVGEENVGSPMLSNSFCDDEFVMAPFQPSAGGRLPTQPIVPRAALRRFRPAQQAKVVYRDSIPSILFWRGERLELGTVSGPWQSSGYWWDGRRWEADEWDAVVSQPLQALRLRHEPEAGTWYVAGQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K0</accession>
    <name>E8X7K0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase IS204/IS1001/IS1096/IS1165 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4489</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71434">
        <property type="protein sequence ID" value="ADW71434"/>
        <property type="gene ID" value="AciX9_4489"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4489"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="5">
        <location>
            <begin position="268"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="503" mass="56520" checksum="4F32A2D103F75F17" modified="2011-04-05" version="1">MRLSFEPLALSLAALSAVRLRGGFTAGIYAGWAICRGKVFWSRSCFRPASSSVLSRLAAGGCFTEPLSGTVLRYSRRTLRSCEALDWITVMIGGQAGARLARRLGLLVSGSTLLRQLRCRARCAPVVAPRVLDIDDWAWRKGHRYGTILCDLESRRVIDLLPDREAGTVAAWLREHPGSEIVSRDRGGIYAQATRLAAPGAVQVADRWHLLRNLSEALKNALSPHHRLLTQAARSSMGEVPGVVTSPQPSVPPWELRASLRNRERRFSRYEEVHRLGQTGASHAAIGRQLGLDHRTVRKFLRTETFPEAQRSPRPGIVDPYAEYLDRRLEQGCRNVSRLWRELRERGFTGQLNIVRRWLRCRRGYQPTSAAAAPHRAAPRISVRQTVWHILKETPSAQTYLEQVYQASPEVSVAAKLAKEFFRLITQRDLPALTPWFEAAKTTALAGFASHLTRDRDAVEAALKLPWSQGQVEGHVHRLKLIKRQMYGRAGFDLLRLRVLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q7</accession>
    <name>E8X7Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573210.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71491">
        <property type="protein sequence ID" value="ADW71491"/>
        <property type="gene ID" value="AciX9_4560"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4560"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_3_0_0"/>
    <dbReference type="OMA" id="LAYEWRF"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="42"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="42719" checksum="6B6B08D4134C647D" modified="2011-04-05" version="1">MTSFYSIWPSVVCVVGLLAFASTPLFSVADTAPTLEIKRVRTLDGLRGFLAFAVVFHHIAIYRNFLLDGNWQDSPSRYYTELGPIGVSLFFMITGYLFWFKLCKEKGRPNWHSLYIGRIFRIGPLYIFAVLLAFALDQVHGAPLPIYTQLKPLVSLGAFQYQDPHMFLAGVTWSIKYEWCFYFSLPILALLARYPKVRTPLLTFAASAFAIAATLMPRGDGWKPTNVSIMLLFSLGMLAVPLKDQLTALPDRYASVMSILLCAAAFLPRTTYAPITSILLGVVFLLVSSGASIFGLLTMRAAIRLGDVSYGIYLLQGLALLSLRFTPVRRFALSSSPHFWLIQFVEVTMLAVTAMITHVLIERPGIKLGRKIAGNAPQETPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X808</accession>
    <name>E8X808_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4662</name>
        <name evidence="3" type="ordered locus">AciX9_4670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71592">
        <property type="protein sequence ID" value="ADW71592"/>
        <property type="gene ID" value="AciX9_4662"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71600">
        <property type="protein sequence ID" value="ADW71600"/>
        <property type="gene ID" value="AciX9_4670"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4662"/>
    <dbReference type="KEGG" id="acm:AciX9_4670"/>
    <dbReference type="HOGENOM" id="CLU_1649742_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="18193" checksum="52B1B73A024963DC" modified="2011-04-05" version="1">MDLRQDTNAHIYRPSQRLRRFFLVAGSFYVLVGTCLFLLTVEHALLPVRPSMTAWLNAYLGPLAGLGLAIIGASQARSYWRRVLILSDTKIGTEFTFGFRELDRNEVIGKRIRWGKQGPQTVLIPKARRFPKIVIHSNFVVDQFYESWIASVPDLGDITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM2</accession>
    <name>E8WVM2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2521</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580866.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2521"/>
    <dbReference type="EnsemblBacteria" id="ADW69551">
        <property type="protein sequence ID" value="ADW69551"/>
        <property type="gene ID" value="AciX9_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2521"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_0"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="806" mass="85087" checksum="C8B5406BF4E43B4C" modified="2011-04-05" version="1">MVDEHTVEEVRDPVCGMMIKPQDAVSHQEYDGHTYYFCSRSCATKFAAAPQRYLQPATKAAPHGNTEAPYICPMHPGVHQLGPGSCPKCGMALEPAVQVAPSTRTQYTCPMHPQIIRDEPGDCPICGMALEPMTITANEANPELDSMTRRFWIGAALTLPLLAIMVSDLLPSHPIQGLLKGPSLGWFELAIASPVVLWGGWPFFQRGWASIVSRNLNMFTLISIGAGSAYLYSVVAVFMPQLFPASFRDTSGQLGLYFEAAAVITVLVLLGQVLELKARSQTSSAIKALLGLAPKTARRISADGQEQDVDLNKIQVGDSLRVRPGEKVPTDGVLTEGSSSVDESMVSGEPIPVEKAKDAKVIAGTINGTGSFVMKTQRVGADTLLAQIVKMVSEAQRTRAPIQRLADTVASYFVPAVLASAVITFIVWAIYGPQPHYAHAPVNAVAVLIIACPCALGLATPMAIMVGTGRGAGEGILIRNAEALEILEKVNTLVVDKTGTLTVGKPILTALAPAEGFDEANLLQLTASLEKASEHPLAAAILAAAQEKKVELLPVDTFQSVTGKGVTGTIRGKKIAIGNVALMSDLGASTETLRGKAEALQAEGQTVMFVATDGRFAGFVAVSDPIKVSTAEAIEQLKKEGIKVVMVTGDNHKTAEAVAKKLGIDFEADVLPEKKAEVVKKLQAAGAIVAMAGDGVNDAPALAQAHVGIAMGTGTDVAMETGGITLIKGDLRGIVKARRLSQHTMSNIRQNLFLAFFYNALGVPLAAGVLYPFFGILLSPMIAAAAMSFSSVSVIGNSLRLRNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN4</accession>
    <name>E8WVN4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">AciX9_2533</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580878.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2533"/>
    <dbReference type="EnsemblBacteria" id="ADW69563">
        <property type="protein sequence ID" value="ADW69563"/>
        <property type="gene ID" value="AciX9_2533"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2533"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_5_0"/>
    <dbReference type="OMA" id="ITPFIFP"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017692">
        <property type="entry name" value="Alt_ATP_synth_F0_Asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03306">
        <property type="entry name" value="altF1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="25906" checksum="917180737451B08F" modified="2011-04-05" version="1">MNLTSDQVIFWQHGFFKLNETILTTWAMMLLMAFGAMLITRHLATEGKISRWQGALEIIITTLESQIKEVGLPDARKYLAFLGTLFVFVATCALCVILPGYKPPTGSLSTTAALALCVFLAVPLYGIREQGLGGYLKTYTQPTIIMLPFNIISELSRTLALAVRLFGNMMSGVMIVGILLTITPFIFPIVMTALGLLTGMVQAYIFTILAGVYIAAATLVPRRQNVAVAAPKALPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT0</accession>
    <name>E8WVT0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ordered locus">AciX9_3688</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581998.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3688"/>
    <dbReference type="EnsemblBacteria" id="ADW70689">
        <property type="protein sequence ID" value="ADW70689"/>
        <property type="gene ID" value="AciX9_3688"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3688"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_0"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="6803" checksum="56CAAA68F0830362" modified="2011-04-05" version="1">MAAKCDLCGKGPQFGNNVSHANNKTRRRWNVNLQPVKAKVDGGSKRMSVCTSCIKTGKIVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT3</accession>
    <name>E8WVT3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding lysin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582001.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3691"/>
    <dbReference type="EnsemblBacteria" id="ADW70692">
        <property type="protein sequence ID" value="ADW70692"/>
        <property type="gene ID" value="AciX9_3691"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3691"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125377_1_0_0"/>
    <dbReference type="OMA" id="ANHYEGI"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14428" checksum="526244878A160559" modified="2011-04-05" version="1">MADFQALQEKYKPVVDVIKQFEGHGAKFDGSELVGEQYHLVAHVPSQVVLDRVWDAIKQVDPQYADLKHEITNTGGQEQEYTIAPGDNLSKVSKLFYGNANHYEGIAKASHIANPDKIQVGQKVTVPVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW99</accession>
    <name>E8WW99_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1424</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579804.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1424"/>
    <dbReference type="EnsemblBacteria" id="ADW68482">
        <property type="protein sequence ID" value="ADW68482"/>
        <property type="gene ID" value="AciX9_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1424"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_5_2_0"/>
    <dbReference type="OMA" id="QERAQEY"/>
    <dbReference type="OrthoDB" id="2077713at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10496" checksum="07B578ECC047F39E" modified="2011-04-05" version="1">MNTKNLIFAFGIGLTVGASVALLYAPQSGASTRKKLKRSAEDASDYLEDTAEYLKEQAERFSSEAEKLVKRARSTVDDTIDQAGGIVAGALKTAQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA3</accession>
    <name>E8WWA3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase like protein, AhpD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1428</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579808.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1428"/>
    <dbReference type="EnsemblBacteria" id="ADW68486">
        <property type="protein sequence ID" value="ADW68486"/>
        <property type="gene ID" value="AciX9_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1428"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_0"/>
    <dbReference type="OMA" id="NRFGVTC"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="18060" checksum="4066B85BA70A9795" modified="2011-04-05" version="1">MEQRLRYTELAPNGIAAMRAVEHYVNTESGLEPVLLELIRLRASLLNGCEYCIGLHSHELTKHNEPQGRIAGVEDWQSSNAFTKRERVAFAWTEAVTNIQDGHASDKAYAAAREYFSEVELVNLTIAITSINAWNRMAIAFRAVHTTKTDVTGDDGGKVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD5</accession>
    <name>E8WWD5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1465</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579838.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1465"/>
    <dbReference type="EnsemblBacteria" id="ADW68518">
        <property type="protein sequence ID" value="ADW68518"/>
        <property type="gene ID" value="AciX9_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1465"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424951_0_0_0"/>
    <dbReference type="OMA" id="FCVNRIV"/>
    <dbReference type="OrthoDB" id="10583at57723"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229995" evidence="1">
        <location>
            <begin position="20"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="639" mass="67810" checksum="7A0A21AE5D389E94" modified="2011-04-05" version="1">MRKVSLAVSAGLLSAVAVAACLTLWHVESSLHTIRRQVAASGSLPFDTITLEPASSHPLFEPVAPPDTFTTGASLAGKLYLAGPGGIASGSTWLRTGQDLPSAPIVALTTARLRGDPLPTLLAATQGQGLLILRPGKPIQQILPRDLAERDITALLPLASGALLLGTRTAGLLVYDGITLTQFRADYATLPITALAGDESDIWAGTRTRGVLHWHAGETQSFDQTNGLPDNQVEDIITRDGTSYVATPLGVAEFTNGRPTRTLGKGLFAHSLALGESNLMVATLDQGLNQIPLTAHSSRISLSNQPLSITHFFKADGTLFAISQDGLLRQDGAAGWQKITTSPSQTLSDRNVAALNFAPDGRLWVGYFDHGLDVLDLTTSHAEHVEDDHIFCVNRIVPDPQRHTMDVATANGLVLFDPTANTPKERQILLRKDGLISDQITDVAFTSTGMTLATPAGLTFFTPAGPQSLYTFQGLVNNHVYTLASETTSAHIVAGTLGGISVLDDSAVRQNLTLSNSGLKRNWITAIVRVPHPSASDTWFVGTYGGGITEVDSTGHVTPLNGANTTAVINPNAMLRTSQHIFAGSLESGLLVYTISSQHWSQITAGLPSRNVTAFAEKDGELYIGTDNGIVRVEEARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG3</accession>
    <name>E8WWG3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2602</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580942.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2602"/>
    <dbReference type="EnsemblBacteria" id="ADW69627">
        <property type="protein sequence ID" value="ADW69627"/>
        <property type="gene ID" value="AciX9_2602"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2602"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_1_0"/>
    <dbReference type="OMA" id="EIVLCNA"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023842">
        <property type="entry name" value="Bacillithiol_biosynth_BshB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04001">
        <property type="entry name" value="thiol_BshB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="27146" checksum="B933CB016EEEBDD4" modified="2011-04-05" version="1">MISGSSPATVDILAIAAHRDDVEQTCGGTLLVQQALGFRTGILDLTQGESGTRGTAAEREAEANDAARILKVSHREALDLPDGNVQNTLENRLKLAAVLRRLRPRVVILPYWQGRHPDHYTSATLGYEACFTAGLSKLVTPGDPTAKPHRPFKILYASLYADVRPTFVVDITPHIETRLQSLLAYRSQYSNQQQGGGLFVPEEEIRERTFATARHYGLLAGARYAEPFVQKEVAMVSDLMHLPVASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL0</accession>
    <name>E8WWL0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2649</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580989.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2649"/>
    <dbReference type="EnsemblBacteria" id="ADW69674">
        <property type="protein sequence ID" value="ADW69674"/>
        <property type="gene ID" value="AciX9_2649"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2649"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_0_0"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23110" checksum="6D615A6D501A4B21" modified="2011-04-05" version="1">MATKTKLPIKPVKSTKSVPLPSSSTPSATKAHILSSKVSYKGKVFSVVTEKVTEPGGVTSTRDIVRHNGSVVILAIGSRTNPDTGAPEPTVLIERQYRHAAGKFLLELPAGRIEPGEAPLAAAKRELIEETGFRAKRWSRLVRYYASPGFLAEHMQVFLAEEIREGLAQPEEDEKIDLLHIPLAELLSMIRDGKIEDAKTMLAVLLYTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN4</accession>
    <name>E8WWN4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3779</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3779"/>
    <dbReference type="EnsemblBacteria" id="ADW70779">
        <property type="protein sequence ID" value="ADW70779"/>
        <property type="gene ID" value="AciX9_3779"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3779"/>
    <dbReference type="HOGENOM" id="CLU_3382107_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="33" mass="3890" checksum="841A08584F662527" modified="2011-04-05" version="1">MTDVLMFFVYWAMVLTPCVIAMYIPLDSVRYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP0</accession>
    <name>E8WWP0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone H1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3785</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3785"/>
    <dbReference type="EnsemblBacteria" id="ADW70785">
        <property type="protein sequence ID" value="ADW70785"/>
        <property type="gene ID" value="AciX9_3785"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3785"/>
    <dbReference type="eggNOG" id="ENOG502ZP0G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2522893_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="8574" checksum="916D68FD6799B65C" modified="2011-04-05" version="1">MTTAKKAPAKKTASKKAPAKKSAKKAAAHCWPGFEPVAGKTPGTKGSCEPKEHQTKGEKKADSKAAAGSKLRKAGGSKAKANKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ2</accession>
    <name>E8WWQ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578708.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0308"/>
    <dbReference type="EnsemblBacteria" id="ADW67380">
        <property type="protein sequence ID" value="ADW67380"/>
        <property type="gene ID" value="AciX9_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0308"/>
    <dbReference type="eggNOG" id="ENOG5032S4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144125_1_0_0"/>
    <dbReference type="OMA" id="SKRWMAS"/>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="15388" checksum="2CC927A38B94DF1B" modified="2011-04-05" version="1">MAEHGVVTTDAEIEAALNRAKVHDNDPLAVTVEHVQDLRLLIVGLSNGRRLVLPMEDLQGLGSVTHEQIQNYELLGRGSGISFPDLDVDLYVPALIEGVYGNRRWMAMLGRKGGSVRSEAKRMASKTNGAKGGRPKKVSAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ9</accession>
    <name>E8WWQ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578715.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0315"/>
    <dbReference type="EnsemblBacteria" id="ADW67387">
        <property type="protein sequence ID" value="ADW67387"/>
        <property type="gene ID" value="AciX9_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0315"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="GQDFSIM"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="913"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1062" mass="114532" checksum="EDAC1940352F31B8" modified="2011-04-05" version="1">MSPSRPFILRPVATSLLMVAILLAGAVAYMQLPVSALPEVDYPIIQVQTFYPGASPDVMASSVTAPLERQFGEIPGLKQMTSSSSGGGSVITLEFSLNESIDVAQQDVQEAINAGFTYLPKDLPNPPTYSKVNPADAPIMTLALTSKTLPLSKVEDLADTVLAQKISQLSGVGLVSIAGGQKPAVRVQANPTALAGYGLSLEDVRTALGTANVDQAKGSISGARQMFTIGANDQLLSSADYNKVIIAYRNGSPVRLSDIANSVDSAENLYQAAWMGTAAKPATKTTDAQDAVLDPAVIINIQRQPGANIIGVVDAVQKILPQLRTSMPSSVNLDVLTDRTNTIRASVKDVQFELVLTIGLVVMVIFLFLRSFSATVIPSVAVPLSIIGTFGIMYLLGYSLNNLSLMALTISTGFVVDDAIVMIENIARYLEEGDTALDAALKGSEQIGFTILSLTISLIAVLIPLLFMGDIVGRLFREFAVTLAVTILVSAVVSLTLTPMMAAKLLKHTPDSEQGKLYRKSEEFFKYVIAKYGTGVRFVLRHQVLTLLVTLATFVLTVYLYIIVPKGFFPVQDTGVLLGITEGPQAISFPEMADRQQKLANIILKDPDVESLSSFIGIDATNTTLNSGRIQINLRDREQRSATATDIIARLQPKVAQIEGLQCFLQPLQDLTVEDRVSRTQYQYTLEDASPTELATWTDKMVAELRKHSSVLMDVASDQQLGGLEAHLVIDRDTASRLGITPQNIDDTLDDAFGQRQVSTMFTQQNQYHVVLEVAPNFQKNPSSLDNIYVKSSNGTQVPLSTFTHFVQQTASLAINHQGQFPAVTISFNIAPGKSIGDAVTVVNQVQADLQLPPSVNAEFQGSAAAFEASLSNEPLLILAALIVVYIVLGVLYESYIHPITILSTLPSAGVGAILALLLFHVDLSVIALIGIILLIGIVKKNAIMMIDFALEAERDHGMEPEEAIYQACLLRFRPIMMTTMAALLGGVPLALGNGTGSELRRPLGITIVGGLIVSQVLTLFTTPVVYLFFDRIGRRYLHTKEADEEFRQHAHEGEHAHVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR7</accession>
    <name>E8WWR7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsR</name>
        <name evidence="6" type="ordered locus">AciX9_0323</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578723.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0323"/>
    <dbReference type="EnsemblBacteria" id="ADW67395">
        <property type="protein sequence ID" value="ADW67395"/>
        <property type="gene ID" value="AciX9_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0323"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_0_0_0"/>
    <dbReference type="OMA" id="VDKIALY"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="129" mass="13720" checksum="0EFC624996A88D67" modified="2011-04-05" version="1">MADETNATPEQQAPAASAPAERAPYVPRTPRPAGGPGGPGGPGGRPAGGPGGGPGGRKFFRRKKVCKFCTEKIDAISYRDVRLLQGFVAERGKIVPRRLTGVCTRHQRRLSLAIKQSRNIALLAFAARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW9</accession>
    <name>E8WWW9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1477</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579850.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1477"/>
    <dbReference type="EnsemblBacteria" id="ADW68530">
        <property type="protein sequence ID" value="ADW68530"/>
        <property type="gene ID" value="AciX9_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1477"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_0_0"/>
    <dbReference type="OMA" id="RYVGEPQ"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230388" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18508" checksum="9947E13E99C57C89" modified="2011-04-05" version="1">MHKPILLAAFALMTVFPATAKPADELIPAALRVSAPDFTLTDVQGKQLTLSSYKGQVILLDFWATTCGGCKVELPWYVDFDKKYRPKGLAVIGLDMYGETPELIKPFMAKWNMNYPVAVGTDALGERFHLREMPLTLLIDRNGKIAVSHAGIVDRAAFEEAIKQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX31</accession>
    <name>E8WX31_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1539</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579911.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1539"/>
    <dbReference type="EnsemblBacteria" id="ADW68592">
        <property type="protein sequence ID" value="ADW68592"/>
        <property type="gene ID" value="AciX9_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1539"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_0"/>
    <dbReference type="OMA" id="AYTLQIV"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="31700" checksum="6614568E9C68589D" modified="2011-04-05" version="1">MRVLKPATLARVLLLGTVLVWGGSFVVVKAALGDASPLLFNLIRMSLAAVVLAGVNWRELHGVTRAQVRAGALAGLFLALGYQFQTFGLVRTTAAKSAFITGLVVVFVPLLTLVPRFRPAGMRAPGWTAGVGACLAFGGLLLVTTPAGTAAKDIFGTIGLGDLLTLVCALAFAGHLLILARVSKGMGAGLLGTLQIADAAGVMLVTLPLEPVHFFHLTGRLVVALGVTSVLATAAAFTIQSYAQQHLPATQTAVILTLEPVFAWLTSMVVLGERLSGRSMAGAGLILISIALIELLPGTIHSTEIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA9</accession>
    <name>E8WXA9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0370</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578770.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0370"/>
    <dbReference type="EnsemblBacteria" id="ADW67442">
        <property type="protein sequence ID" value="ADW67442"/>
        <property type="gene ID" value="AciX9_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0370"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_0_0"/>
    <dbReference type="OMA" id="FLNIDGM"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230410" evidence="2">
        <location>
            <begin position="29"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="141"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="316"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="571" mass="61731" checksum="D4040AFA21E23E78" modified="2011-04-05" version="1">MTFPTSVRSPALSLAAVAVLLSAPPLRAQVPAAEAKGFATIQQAELRTDLTYIASDALEGRLSLQPGDEAATKWVAEQFAKAGLKPAGHDAAGKPSFLQPFTLIEYRPDRAASVITLKRAGKTTEYHAPQAFGAYKSAVDVTAPVVFAGFGITAPELHYDDYANLDAKGKIVLIFDHEPQEDDAHSVFNGTGNTRYATARVKVLNAQAHGAVAVLIVAEPNRKHLTNAERSARIGSSAVRPIQLPIQAIQDDEIHIPSGLVLDAVAAELFATSGTTPAAAQTIIDRDLKAQSMPLPDTTLSLHLRNVSERTGVTNNVVALLPGSDPKLAPETILISAHHDHDGEAACADPAHPPVTNPPDPHPCPQIWHGADDNGSGTVGVVALARAFAENPVKPKRSVLFVVFASEERGLLGAYWMAAHPLRPLALTRAQINFDMIGRDEAASPQTDGLIEIPKDTTNRLNLIGALYSPDYNRTVVEANKTVGLTLDDRFDHESALNVFFRSDQFPFVLHNIPAFWWFTGFHPDYHHTTDTVDKIDFVKMQKILQLAYLSTWQFATETAPPRFIANPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB4</accession>
    <name>E8WXB4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0375"/>
    <dbReference type="EnsemblBacteria" id="ADW67447">
        <property type="protein sequence ID" value="ADW67447"/>
        <property type="gene ID" value="AciX9_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0375"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_0"/>
    <dbReference type="OMA" id="WGMSEAG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="332" mass="36718" checksum="DBC984E2396F5899" modified="2011-04-05" version="1">MSMKTVKLGSQGAVVSREGLGCMGMSEFYGERNDEESTATLHRAIDLGVTFWDTADTYGIGDNEELLGKTLKTRRDEVFLATKFANHRKKEDPKFWEINGKPAYVHAACDASLKRLGIDYIDLYYQHRVDPNVPIEETVGAMAELVKAGKVKYLGLSEASPATIRRAHKVHPITALQTEYSLWERHVEAEILPTVRELGIGFVPYSPLGRGFLTATITKKEDLGPADFRAERYPRFSGEAFDKNQVLVERVKAIAEKKGVKAGQLALAWVLAKGEDLVPIPGTKRRKYLEENAAAAEIQLSAAEIAELEAAVPLDEIAGERYAPANLKSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI2</accession>
    <name>E8WXI2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579917.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68598">
        <property type="protein sequence ID" value="ADW68598"/>
        <property type="gene ID" value="AciX9_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1545"/>
    <dbReference type="eggNOG" id="ENOG502ZDRE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1600385_0_0_0"/>
    <dbReference type="OrthoDB" id="2215576at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18454" checksum="1DFEC413C4BEAA37" modified="2011-04-05" version="1">MTHLNDYLESNSVRTLLAIIAILVSIGLFWLNKKKKTLSYEILRNDRLFKLNLNLENRIQITVDGSPAEDIRLVIVDIQNTGNEPIKRDEFDMPLRFNFGNGAEIVAARVLSTKPADLGALIETGKTDVTLQPLLLNKGDGLSVEILVTGQSRPSPTLPVLSAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS8</accession>
    <name>E8WXS8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2749</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581088.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2749"/>
    <dbReference type="EnsemblBacteria" id="ADW69773">
        <property type="protein sequence ID" value="ADW69773"/>
        <property type="gene ID" value="AciX9_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2749"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442642_0_0_0"/>
    <dbReference type="OMA" id="ETYIQNM"/>
    <dbReference type="OrthoDB" id="212380at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233968" evidence="2">
        <location>
            <begin position="26"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="625" mass="68415" checksum="3807A1B82C9A7A21" modified="2011-04-05" version="1">MISRNQKIAGLSLALIVASATQAKAFPVFGSKKPKDANAGKKLTPGQSALIDKAVLREKEVIKVVKERTPLVETYIQNMKQDPVMRQVPDSDQHFLGRVDFGKVIGDDAFKQGPKAGSGEKGSKLGFFKNSAGFLGGLGGSLHLQFHEAGFVSMLLMDSYEFDKQHYNFGFVRNDFLGNVPTAVFDVTPAKNNDRGRFFGRIWVETRNGNVVRFNGDFAGSDKEYQDYYHFDSWRTNVQPDLWLPTSFYVEESDPKSRTSTLKFKAINHVWGYQLKVPPVQAENTSLEVVGAQDVSNDAQDVSPLGAQRAFSKQAEDNVVEKLFEAGLIDAPSDFDKTLEALANNILAYNNIPVAGTIHVRTLLTEPLESLSVGNTIILSKSLIDTTAVQSTDGAQQEGNLYAIVAFQLAHILAGHKLDTKYAFNDRLLFPSDSSFKRIPMHHTDADNIEAAKKTMELLSVKELEGGQKYFGLYLQQLQQRVKGLKALNTPAIGDGLVKSETDPTFWLAAMMPKGDKLNVKDLKQQAAEPLSSFLRFDPWTDQVITMHTALEPILSASDKMPFEVAPVYLKLGYYKAPAEPVPSPAGPAPADNTAPAPAPAPTDNTVPAQPTAPTPTPTPTATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY90</accession>
    <name>E8WY90_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1667</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580036.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1667"/>
    <dbReference type="EnsemblBacteria" id="ADW68717">
        <property type="protein sequence ID" value="ADW68717"/>
        <property type="gene ID" value="AciX9_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1667"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022604_0_0_0"/>
    <dbReference type="OMA" id="MNINPAY"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230451" evidence="2">
        <location>
            <begin position="25"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="640" mass="67835" checksum="0904415045780D54" modified="2011-04-05" version="1">MNFERTSSSLLLSALLLTQTSALVAQQAAQVLPAAPTVSLDIPHSHNPIETYRAAHVPAPDLANSARIDTLVHDGVLELSLRDAIALALENNLDLAIARYNIPIAKADVLRTKAGGTFLGVNTGVVQNTPGGGFGGFGSGSNGAGAGGTSGGAGGAGAGASGLVQSTLGTGSLVSSYDPNVSGTISYQNSTTPLSSEVIYGVPTLHQGDFSGTVNYTQAFATGTSIAVGFNSDRLTSNSPFTSLTPELDGSFQALVRQHLLSGFGLGPNLRYLRIARNNQKISDQAFELQVVSTVTQIANIYWDLVAAYEDEQVKSHSLDFARQTLDKGHKQLDLQAIPALDVLKDEAEVANREQDLTIARSQLQFQSLLIKNALTKNLDDPILEAMPVRPTDLATVDLKAAPAPAAATDDLVEQALNRRIEINESNIDLQNRKISRDALRNSLLPQVDLVGYYGGTGLGGVDNPLTNTPSTAPGGYGGTFKNTFNNSAPNYYVGVNVNVPIRNRVAKSDQVRSELESRQAEVRLQQQRKQIRIEVRNAQYSLDQSLARVTSAMKARDLSERLFTISGKEQELGAGSALQTLAARRDLATAESALVAALTAYQKAKVELDRATGQTLTANTISIESARSGTQPASTTTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB3</accession>
    <name>E8WYB3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2796</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581134.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2796"/>
    <dbReference type="EnsemblBacteria" id="ADW69819">
        <property type="protein sequence ID" value="ADW69819"/>
        <property type="gene ID" value="AciX9_2796"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2796"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_0"/>
    <dbReference type="OMA" id="CANDDEY"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="83"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="33611" checksum="A8606052E8959778" modified="2011-04-05" version="1">MKIQVRTLVLAGLTMVCGWRFSAGQAEMKAVATEPPKGFAEAIVLWPGGAPLARGTDEGDVPELFSYPAPGAGPHAAVIVMPGGGYNHLVMEKEGAVEARWLNERGVSAYVLEYRLFPKYLYPAPLLDGARAVRYVRANASKLGVKADAIGVWGFSAGGHMAGYLAAIHDAGKAAAGEAVERVSSRPDFAILSYARLTMSADVPRNGSMEDLIGPKPTQEIIDAIDPGKHVTKDASPSFIYSTGGDMSVDPLNASVFYEALKRAGVPVELHIFQLGPHGTGMAQTLKPELKELAVWPLLLENWMRQNGWISDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB5</accession>
    <name>E8WYB5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2798</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69821">
        <property type="protein sequence ID" value="ADW69821"/>
        <property type="gene ID" value="AciX9_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2798"/>
    <dbReference type="eggNOG" id="ENOG5032ZXM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130801_1_0_0"/>
    <dbReference type="OMA" id="NQNGQMD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17141" checksum="93E27F123523C981" modified="2011-04-05" version="1">MFSITHFSEIDAKSFCPDTLIFGDSMANRYGEAALMAVRMETYGKNPSPLERWDDAVKKLYPTTPAGQKKGGPRTAFLGLCEAGLVKGIHGDAFASQHNRNKTYAVEAVKLLQAGTHKSVTQLWAAVTEGDEVAHAAQMDVVLALWKNGLILPVPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC6</accession>
    <name>E8WYC6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2809</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2809"/>
    <dbReference type="EnsemblBacteria" id="ADW69832">
        <property type="protein sequence ID" value="ADW69832"/>
        <property type="gene ID" value="AciX9_2809"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2809"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479539_0_0_0"/>
    <dbReference type="OMA" id="VLTAWPA"/>
    <dbReference type="OrthoDB" id="516754at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="548" mass="61414" checksum="1F4BB88AB4830BA8" modified="2011-04-05" version="1">MKSQPQAAGKPAPKFSEFVAPVSHPLPLWILYPLFFMWIYLPHGTLLRLPYFWDEAGYYIPAALDFLHTGSLIPHSTLTNAHPPLPSILLAAWWWISGFTPWTTRTFICMVSAAALLGLFRLARSVAGNAVAAAVTILTALYPIWFTQSTLAHADIFAAAFTLWALSFYLEPYGSSERRNYIAVAVLFSLAALSKETAIITPGALALWEFVRLLTEGKASKEFPGAPSWRWITALLTPILPLALWYAYHYHQTGFIFGNPEFLRYNASANFTPLRVLLSLWHRAVHLTLHMNMYVPVLCTVAVLLMPRRPDETLPPIRKPLLPTLLVIVLGNAFAFSILGGALLTRYLLPVYPLILLVCVCIWKERLQRWVWLAVLTGVAFFAAQHINPPYAFAPEDNLTYRDMIVLHQQAIHILETRFPGATVLTAWPATTELEHPELGYVHHPLKIAPVDNFSPAEMEKAATDPGTYDTALIFSTKWTPPPGHFNLSRSSQGSDTRFFDFHNDVTPAQAAIILHGEIVWQASRNGEWAAVLHFPRVVEASLTPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG5</accession>
    <name>E8WYG5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2848</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2848"/>
    <dbReference type="EnsemblBacteria" id="ADW69871">
        <property type="protein sequence ID" value="ADW69871"/>
        <property type="gene ID" value="AciX9_2848"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2848"/>
    <dbReference type="eggNOG" id="COG3361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081757_0_0_0"/>
    <dbReference type="OMA" id="HFLTARW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="28468" checksum="86D932E9F48109F7" modified="2011-04-05" version="1">MAHRPYPLPTRPWRMKQRWNDLLFAHYPIPPSQMAPLIPTGLELDTFDGQAWLGVVPFWMDQVENRTIGDSTLSIPTTRIFSELNLRTYVRSPRTGLCGIYFFSLDCSSPLAVIGARTLFHLPYYFADINRTPSITIPDQTHYVSRRQLTSSNPRFEATFRPTGPVTLSTPGSLAAFLTERYCLFTTFRNCVLRGDIHHLPWPLQSAEADIRTDELPQAHNLTLPHDTPPILHFSSSLDVYIWSLQPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU3</accession>
    <name>E8WYU3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1731"/>
    <dbReference type="EnsemblBacteria" id="ADW68779">
        <property type="protein sequence ID" value="ADW68779"/>
        <property type="gene ID" value="AciX9_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1731"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067526_0_0_0"/>
    <dbReference type="OMA" id="KAIWGYD"/>
    <dbReference type="OrthoDB" id="1678187at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="114"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="36618" checksum="64AD95C6B68F787A" modified="2011-04-05" version="1">MLAAGLAFGTMVGAAQQTAPAAGIGAKAPNAVTPPAAGQAPAQAKTPLQLQSLDPSTRADPFPPVNPKYFTATTPTVATVDSYLHALLGWDANRIWRVEAIQKTAAPGVSKVIVYVSDRAANSKVQTAVFFITPDGKHALADTAVNPFGEKPYADISAMLKQRADGPFHGNGAKDLELVEFADLQCPHCKDAQAVMKRLVDDFPKAHIVYQNFPLTEIHPFAFKAAAFGVCAAKKSNDVFFTYAQAVYDTQGALTADTGDQTLKDAAAKAGLDPAATAACAATDATKGEVESSIKLAEDVGVTETPMIAINGRLLPLSIPYETLKSIIIFQAGLDGAGDAAVTAAGHGLIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV5</accession>
    <name>E8WYV5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1743</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580110.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1743"/>
    <dbReference type="EnsemblBacteria" id="ADW68791">
        <property type="protein sequence ID" value="ADW68791"/>
        <property type="gene ID" value="AciX9_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1743"/>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_0"/>
    <dbReference type="OMA" id="PIFPCWN"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230082" evidence="1">
        <location>
            <begin position="20"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="267"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="739" mass="81574" checksum="8E3EDDDBD93A4F4D" modified="2011-04-05" version="1">MRILLLVPLLALLSSDLQGTAQTQPAQWVNERIGTANEGQTFPATGPPFAMTQWTPQTRDGNVKCVAPYYDKDTRIQGFRGSHFLSGSCTQDYGSMTIMPLTGPLKLDAVERASGFDRASEVLTPYRYAVTLRDYNIDAEVTGTTRAGILNFKFNNPGKSWILVQANTSPGDGKIQIDPTRGEILATIPARRLYAGNGQPAGFSGYSVVQFDHPFHTGGTWAGKDAHAGAIEQDGKPGTPGAYVSFDLKPGESVKVKVGTSFTSLDEARKNLQAEIPDWNFAEVAAHAQKDWNTALGRIAVKDETARKRIFYTALYHSMLLPRTFSDVDGSYPSFAGGSRVETAKDFVYYTDYSLWDTFRAVHPMLTILDPAREVDMVKSLIAMGQQGGFLPIFPAWNSYTSEMVGDHAVTVIGDAYLKGLRGFDIEAAYQLMKKNALETPKDHAEYLDGKGRRALESYLKYGYIPLEDKVPDAFHKQEQVSRTLEYAYDDFVVAEVAQSLDHQQDADLFHHRAQNYRNVIDPQTGFARGRHADGTWDTPFDPAVKYPYITEGLPYQYTFFVPQDLPGLITLVGGNEAFIRKLDALFAGNYYDHGNEPSHHIAYLYDNAGAAWKTQQHVRSIMESQYSDAPAGLAGNDDSGQMSAWYVMSALGFYPVTPGVPVYQIGSPLFDDATIHLPSGKLFQIHAAGASSGRQYIQSATLNGTPLNRSWIKHSEVVAGGNLVFEMSSHPNPDWPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ43</accession>
    <name>E8WZ43_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ordered locus">AciX9_2935</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581273.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2935"/>
    <dbReference type="EnsemblBacteria" id="ADW69958">
        <property type="protein sequence ID" value="ADW69958"/>
        <property type="gene ID" value="AciX9_2935"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2935"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_0"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="470" mass="51919" checksum="05CFAD728261A815" modified="2011-04-05" version="1">MFEKIANIFRIEDLRKRVLFTLGLLAIYRLGAHIPTPGIDAKQLAQFFNNNSGSALGLVDLFSGGNLRRLTIFALGIMPYITASIIFQLLTVIYEPLAKLQKEGEMGRRKITQWTRYVTVMLGIVQSTAIALTLTNTQTGQSMVTISKWAFIPMCVLTLTAGTAFIMWLGEQITERGIGNGMSLLIFTGIVVGLPRGIEELYTKATTNAWGAFTPIALLILVALMVAVVAFIIYVERSERRIPVQYAKRIVGRRMTQGGATHLPLKVNSGGVMPVIFASSILSAPLLFAGMSFFGSAKLQDTTFFGPILRAIAPGEPLYELLYIVAIIFFAYFYISIVFRPDDIADNMRKYGGFIPGIRPGRRTSDFINDVLTRITLVGAVYLIIISIIPTLLISGIHFNHIPLIGAAFEHLPVWVTHGLGVNFYFGGTSLLIVVGVAMDTVQQIESQLIMRHYDGFSPKSGRIRGRRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ58</accession>
    <name>E8WZ58_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0589</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578988.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0589"/>
    <dbReference type="EnsemblBacteria" id="ADW67660">
        <property type="protein sequence ID" value="ADW67660"/>
        <property type="gene ID" value="AciX9_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0589"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_2_1_0"/>
    <dbReference type="OMA" id="VQRYTDG"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="16551" checksum="E5B16A443B0B07C3" modified="2011-04-05" version="1">MKTSLTVAALGAMVALGGCKADPPGAMETRVVVAAKHSLFVHNKSEKNPLPDTPETVAAGKEAFGHYCAACHGIDGQNTGVPFADRMSPPVPSLASADVQRYTDGQLKWVIDYGLWPSGMPGSKGMLSDEEIWSIVRYTRHLPPAGSAGEPEMYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ90</accession>
    <name>E8WZ90_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0621</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579020.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0621"/>
    <dbReference type="EnsemblBacteria" id="ADW67692">
        <property type="protein sequence ID" value="ADW67692"/>
        <property type="gene ID" value="AciX9_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0621"/>
    <dbReference type="eggNOG" id="COG1556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090664_0_0_0"/>
    <dbReference type="OMA" id="VPDHHIC"/>
    <dbReference type="OrthoDB" id="1580190at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="125"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="24362" checksum="5109DE5D03433280" modified="2011-04-05" version="1">MSSNLKNPAREAILSRINMALLPTPESQPEDHIATSWSAIPRTFRHDTQASPQDVLHLLIDRLHDYDAQVLTCTPSGITESIAKMLTARGVRKLLLPAGFPEDILPQGFEYIPDGREGESLTAAQLDATDGVITLSTLAIAETGTLVLQNVPGQGRRAASLVPDYHLCLVNAADVKATVPEAVAALQPTAALPTTFISGPSATADIEMTRIKGVHGPRFLDVILISSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB1</accession>
    <name>E8WZB1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0642</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0642"/>
    <dbReference type="EnsemblBacteria" id="ADW67713">
        <property type="protein sequence ID" value="ADW67713"/>
        <property type="gene ID" value="AciX9_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0642"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_0"/>
    <dbReference type="OMA" id="IAVYRHQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23207" checksum="717959417783AFE6" modified="2011-04-05" version="1">MPKMSSPLALPRKPRADAERNRERILEVAKDVFTRDGAAASLDEIARQSSIGNATLYRHFPTREDLIEAVYRTEVEKLAAAEQRFAAIMPPLEALRAWMLLFIDHVAEKKLIIPAMDTVPGGSLRLIEGARSTIHNAFLNAVQRAIASGDLRSDTNPDDLIRALIGVFHTTASPGWESSARRLVDILIAGSRSTSERSIAWISSPSALPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE1</accession>
    <name>E8WZE1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_1781</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580148.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1781"/>
    <dbReference type="EnsemblBacteria" id="ADW68829">
        <property type="protein sequence ID" value="ADW68829"/>
        <property type="gene ID" value="AciX9_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1781"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="OMA" id="QAGWMPT"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="6"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="413" mass="43400" checksum="7B672F7770DD33F8" modified="2011-04-05" version="1">MHNHRVVVTGVGLISPVGTGTEETWAALLKGQSGIAPITLFDALRFSCRFAGEVKNFVPENYIDRKDIKKMGRFIQFAMAATQFAMAQSGLVITEENADRVGVYVGSGIGAFEVIEREHSKLLTGGPDRVSPFFINATIANLASGQISIKYGAAGPSLTVATACTTGAHGIGEAWHVIQRGDADVMICGGSEAAVTPLSVAGFASMRALSTRNDSPTTASRPWDTQRDGFVVGEGAGILILETLEYAQARGATILAEVSGYAANSDAFHTNAPPEDGRGVRKVMQLALKSAGIEPHQVGYLNAHATSTPLGDRAEAQAIAATFGPHAKDLLVSSTKSMTGHLLGGAGSLEAGITVLALRDQIAPPTTNLETPDENIKLNLVRDTPVPVAMDYAMTNSFGFGGTNASLIFRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG0</accession>
    <name>E8WZG0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1800</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580167.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1800"/>
    <dbReference type="EnsemblBacteria" id="ADW68848">
        <property type="protein sequence ID" value="ADW68848"/>
        <property type="gene ID" value="AciX9_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1800"/>
    <dbReference type="eggNOG" id="COG3222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075662_1_0_0"/>
    <dbReference type="OMA" id="IGTDCPG"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="25956" checksum="F359DCA983F6C65D" modified="2011-04-05" version="1">MSYPILDPDFPIPALGHLCALTVMAKAPKAGRVKTRLSPPLTLEQTAALNICFLKDTTANLATVVGGAGLISYTPVGDEALFDGLLPETFGLVAQRGDGFGERLLCAAKDVLAIGYGAVCLIDSDSPTVPGAVFAKAVEELARPGDRVVIGPSDDGGYYLIGLKVAHAAPFERITWSTGTVFEETVERCREAGLEVVVLPVWYDVDDAATLAVLKRELLEGVRPGFAEMDGYSAPKTVGFLMELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI5</accession>
    <name>E8WZI5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">AciX9_1826</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580192.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1826"/>
    <dbReference type="EnsemblBacteria" id="ADW68873">
        <property type="protein sequence ID" value="ADW68873"/>
        <property type="gene ID" value="AciX9_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1826"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_0"/>
    <dbReference type="OMA" id="GSMYILD"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrA_inter" evidence="14">
        <location>
            <begin position="214"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="UvrA_DNA-bind" evidence="13">
        <location>
            <begin position="344"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW68873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109490" checksum="B94E08967436BD2F" modified="2011-04-05" version="1">MTDQTHTNASPNNQITIRGARTHNLKGIDVDIPHNALTVVSGVSGSGKSSLAFDTVYAEGQRRYVESLSAYARQFLERIEKPDVDHVDGLAPAIAIKQKNQTRNPRSTVATATEIYDYLRLLYARCGTVTCLHCGGIVKRDSVDEIVATILALPEGTRTHALFPITRAEIRIEALQPSSVEETEAPKPAKKAVKKSAKKAATVNIAAATLTDPIKDRLLELRRRGYNRLFQNGAIVEFSTPESLLELDFSKPIFVLIDRLALSPDIRTRLVDAIETGYRESGEIQFHTLPRDEAAPQQFRFSSAFECTTCHRAYREPEPRLFSFNNPFGACPRCQGFGNTIDFDPNLIIPDRSKSLTGDAVAPWASGKYRPHHAEMLRAAKAANIPTSVPWYDLTPAQQSFIEDGSGSFPGIRGFFRDLDRKKYKLHVRVFLSKYRGYALCPDCRGTRLRAEARAVLLSGKNICEVSALTITGATEFFDALNLSPSQMEIAGKVLEEVRQRTHFLHQVGLDYLTLDRLSSTLSGGESQRIQLATSLGSRLVGALYVLDEPSIGLHTRDTAKLIRIMEDLRDLGNTILVVEHDPDVIRAADYLLDLGPGAGELGGQLLAAGTVAEVTRNPASITGKYLSGRLTIPIPKVRREPGRERLKLTGARIHNLRGVDIEIPLNLLCCVTGVSGSGKSTIVHQVLYRALQQALGQTEGADPTGLYRDLSGTQHLNEVILVDQSPIGRTPRSNPVTYIKAFDDIRALFAAQPDAKRKSYAAGAFSFNVPGGRCDVCEGDGTVTVEMQFLADIELPCEECNGTRYKAAILDVKYKGKNIHDVLNMTVKEALVYFAGHQKIVDKLYVLDEVGLSYVRLGQSATTLSGGEAQRVKLASHLATARSVSNRSSLNEAAAKARSRTLYILDEPTTGLHFDDVAKLLAAFRKLIEGGGSLLVIEHNLDVIKSADWVIDMGPEGGNAGGQVVAIGTPEDIAANKASHTGHWLGPVLEATAHHEPIPVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN0</accession>
    <name>E8WZN0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2981</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581318.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2981"/>
    <dbReference type="EnsemblBacteria" id="ADW70004">
        <property type="protein sequence ID" value="ADW70004"/>
        <property type="gene ID" value="AciX9_2981"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2981"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_0"/>
    <dbReference type="OMA" id="MPDHRLG"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="33813" checksum="3F8C88DA0871982F" modified="2011-04-05" version="1">MPHAAPIRLIAIDIDGTLLSHEGRVGAPNQAALALARSLGVEVVIATGRRHCYAMRVLRDIGLPESAVLISSNGTVVRNLSSQLIERTHMSPEATALLCNHLAGFRNALVITFDKVGPDGEDARGALVVEELAEIHASIERWVTANELYIVHVNPIENALKNDAPIQAMLVGTMDRMAQAEALLVSHPGVAAVGETLSGGLISLNRTAYPERDLSILDILPAGCSKGAALLRLAASRGIQPSEIMAIGDNWNDLSMLEVVGHPVLMGNAPEDLKTLARQHGWRIGLPHTESGVAEAIESALTSALTPKSHETTQPTLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW1</accession>
    <name>E8WZW1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0702</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579100.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0702"/>
    <dbReference type="EnsemblBacteria" id="ADW67772">
        <property type="protein sequence ID" value="ADW67772"/>
        <property type="gene ID" value="AciX9_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0702"/>
    <dbReference type="HOGENOM" id="CLU_2649371_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="76" mass="8801" checksum="F477087B00E5E403" modified="2011-04-05" version="1">MKLDNEFLFLTAFAFVIFSAIAFFFGRFTDHLRRHSRRPLPPRAFLLAFRLWFSALALGALALLLFSRHGLFAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X040</accession>
    <name>E8X040_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1890</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580255.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1890"/>
    <dbReference type="EnsemblBacteria" id="ADW68936">
        <property type="protein sequence ID" value="ADW68936"/>
        <property type="gene ID" value="AciX9_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1890"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_0_0"/>
    <dbReference type="OMA" id="PGMCFSV"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="143"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="361" mass="38233" checksum="5CF03A01D351BD2B" modified="2011-04-05" version="1">MIPTARKRKLAAAIAKSGAEALLVTNLADVRYLSGFTGSNAVIVMRGGRGTLFTDGRYTAQAAAEVDGLKVVIADQPVVPTACAWAVAEGILSCGFDETQTTVAALDGLKAALPAKLRKSFFVAVGPLIAKLREIKDEDEIDRMREAAALGCRLFDECLEHVVAGATEMEVAMALEYMARLNGAERMSFETIIAGGERSALPHGRATTAKIPKRGFVTMDFGVVLNGYCSDMTRTVHMGRAKAGEREAYEAVLAAQEAGVAAVKAGVTAQAVDQAARGVLEGAGLAEWFTHSTGHGVGIEIHEGPRLGKKQEQKLKAGMVVTIEPGVYMPGKFGVRIEDTVLVTVEGCEILTPTTKAWIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X069</accession>
    <name>E8X069_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3030</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3030"/>
    <dbReference type="EnsemblBacteria" id="ADW70050">
        <property type="protein sequence ID" value="ADW70050"/>
        <property type="gene ID" value="AciX9_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3030"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="CHEFRNP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="42981" checksum="B60DB8C3262945A3" modified="2011-04-05" version="1">MMPEDLNTTHLTAPAQPHVTKGDAPEQPWQALLDSAGEGIWGVDLEGRCTFVNRAALRMLGFDAQELIGQNMHAMIHHHHADGSVYPAEDCSVYNVFRRNRPVSNEVDHVFRKDGSYFWIELSAQPILHLDKVQGAVVTFRDVTQHRMAEQALRRSEKLAAVGQLASSIAHEINNPLEAVLNLVYLVRGADTLEDARHYANLAEIELVRVADITMQTLRFHRQQTAAAPVNLEDTITAILRLYASRFPARRIKVEQYLRASHEPYLLEGDIRQVLNNLIRNAYDAMPHGGTLTIRLHSATCLKTSIPGVRITIADTGTGFLPAMRGHLFEPFHTTKEVTGTGLGLWITKGIVDKHEGRIYMRSREGQGTVFTIWLPVQSAAAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X070</accession>
    <name>E8X070_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_3031</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581365.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3031"/>
    <dbReference type="EnsemblBacteria" id="ADW70051">
        <property type="protein sequence ID" value="ADW70051"/>
        <property type="gene ID" value="AciX9_3031"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3031"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_2_0_0"/>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="294"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="516" mass="55647" checksum="81F886C1E1254A14" modified="2011-04-05" version="1">MNVIKQEDLIESVADALQYISYYHPVDYITNLARAYEMEESKAAKDAMAQILINSRMCAEGHRPICQDTGIVTTFLKVGMEVQFVGPDGGPANMSLQEMVDEGVRRAWLNPDNKLRGSILRDPAFSRKNTIDNTPSVVEVSLVKGTTVDVTVAAKGGGSEAKSKFVMLNPSDSVVDWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAMLLAKQSLMDPIDMQELKARGAQTNIEKLRVELYDKVNSLGIGAQGLGGLTTVLDVKILDYPTHAANLPVAMIPNCAATRHAHFVLDGSGPAELVPPSLKDWPKLEYDVHTARRVNLETVTRADVETWKPGEIVLLTGKLLTGRDAAHKRMTDMLNRGETLPVDFNGKFIYYVGPVDAVRDEAVGPAGPTTATRMDKFTRQMLEQTGLLGMIGKAERGEAAIEAIRDNHAVYLMAVGGAAYLVSKAIKHSRVLAFEDLGMEAIHEFVVEDMPVTVAVSADGTSVHQTGPAEWQKRIAASQSVGGVAILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G4</accession>
    <name>E8X0G4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579154.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0759"/>
    <dbReference type="EnsemblBacteria" id="ADW67828">
        <property type="protein sequence ID" value="ADW67828"/>
        <property type="gene ID" value="AciX9_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0759"/>
    <dbReference type="HOGENOM" id="CLU_2861456_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7148" checksum="5E5546095035C077" modified="2011-04-05" version="1">MNVDPKTDRIGGTASLMFSVICAWFAWMDWQGGQSIWKVWVVMCVVLALNGVAMFVHASRTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J8</accession>
    <name>E8X0J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0794</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579187.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0794"/>
    <dbReference type="EnsemblBacteria" id="ADW67862">
        <property type="protein sequence ID" value="ADW67862"/>
        <property type="gene ID" value="AciX9_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0794"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637375_0_0_0"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="430" mass="47505" checksum="80FD6BEFA35D2393" modified="2011-04-05" version="1">MTNYIAKLISWRREPSRPLLPSERLERAAALRRYFNQAVLVIFPILGGLAAWGIAAQDPSVYLGTAIVRLEMNPLKGGMRLKNQAYGDEIAIMLSEPGLQTAVDTLSQEDRQKLSRKEGGHKARRQSSTDPDAHLRATLRAGLRAERIPHTAMLRISFTSPDPQLAGEIPNTVVRAMMLVNLDKAKRRTGRAEAFFRTPVKALQDEVQAFRLKEHSLAEGLLTPTLPPPAAPPPLDPFLAARAARKGARTATSSETTPPPAPRNSEYESQAAILSAFTTELHRSQREKQLTSLQAGMLAKANEQNRNVFDDGANDLSRAITAAMSRYDSLAATLSQHHPEMAAEAAEIEQLQAEIRALRTRQLELAKVKVLIASGKVTRLLQGTQKEQTLLAEIIDRQRRNNLLYQNIAVEESVLQTLEPGCNPPGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S0</accession>
    <name>E8X0S0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1975</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580340.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1975"/>
    <dbReference type="EnsemblBacteria" id="ADW69021">
        <property type="protein sequence ID" value="ADW69021"/>
        <property type="gene ID" value="AciX9_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1975"/>
    <dbReference type="eggNOG" id="ENOG502ZBRH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112314_0_0_0"/>
    <dbReference type="OMA" id="SNRFERW"/>
    <dbReference type="OrthoDB" id="1625522at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20006" checksum="D54B1E42BFCF9CE9" modified="2011-04-05" version="1">MPRNLDPTFSASLSAPLFGPVFLVMLTFKSQTTYVWSGAGTLIWNGNTYLGVGSLGKVDSIKEGIEVHADGTSLTLSGIDKVYLGEALTDIQIGAPATIHFGNYLNGALIGAPFLIFRGCVDKPTIHTGTDTVSISLALENRMVDLQRASNRRYTATDQRAHYSDDTAFNWVEKMNDISLRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V8</accession>
    <name>E8X0V8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581456.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70142">
        <property type="protein sequence ID" value="ADW70142"/>
        <property type="gene ID" value="AciX9_3128"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3128"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_0"/>
    <dbReference type="OMA" id="MYDWGKD"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="12907" checksum="7CEE270E19EF07D6" modified="2011-04-05" version="1">MKAKDAALSRACSAQELEDALHVLDGRWKTLIIYHLFTAPVLRFSDLQRAINGISQKMLIQQLRNLEDDGVIFRKVYPVVPPKVEYGLTKDGLALRPALQALQDWAKSRTSFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y6</accession>
    <name>E8X0Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3159</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581483.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3159"/>
    <dbReference type="EnsemblBacteria" id="ADW70170">
        <property type="protein sequence ID" value="ADW70170"/>
        <property type="gene ID" value="AciX9_3159"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3159"/>
    <dbReference type="eggNOG" id="ENOG5033KMD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153796_0_0_0"/>
    <dbReference type="OMA" id="VYNSELH"/>
    <dbReference type="OrthoDB" id="20164at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15618" checksum="4C429D8F0DE98FA5" modified="2011-04-05" version="1">MDTILRILKTAGGWNHGLHLHIENPPFMALVIEAGDESGPCGLPAISVCHYGEQNGDAMLYPEMCFELGLAGGAHLNPYYWRNDYVAVEQWSRFIQCGMYVYNSELHDQHQKFAKLWDKNLREQRFLEAFERQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X116</accession>
    <name>E8X116_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0814</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0814"/>
    <dbReference type="EnsemblBacteria" id="ADW67882">
        <property type="protein sequence ID" value="ADW67882"/>
        <property type="gene ID" value="AciX9_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0814"/>
    <dbReference type="eggNOG" id="ENOG5030NBT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203068_1_0_0"/>
    <dbReference type="OMA" id="YMENGFF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5953" checksum="24C86F02E4B1B4C8" modified="2011-04-05" version="1">MTQPIPEDQADPTELSPEDFYFDGPYMVFTAAYHLKRGYCCNSDCRHCPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B4</accession>
    <name>E8X1B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2023</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69068">
        <property type="protein sequence ID" value="ADW69068"/>
        <property type="gene ID" value="AciX9_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2023"/>
    <dbReference type="HOGENOM" id="CLU_2105523_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="12632" checksum="67CFEEEC50FF8FFD" modified="2011-04-05" version="1">MAVNLKLESIRLTISQMTSASNGNAEAECFIETLQAYEHMLMRQRLSIAMSVDDLAALDQRAKYCSSMLAGFAEDAPEEMAGWYHGALPINGSFALANLLSRLVMDFSEYLGISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E8</accession>
    <name>E8X1E8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3172</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581495.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3172"/>
    <dbReference type="EnsemblBacteria" id="ADW70183">
        <property type="protein sequence ID" value="ADW70183"/>
        <property type="gene ID" value="AciX9_3172"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3172"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_0"/>
    <dbReference type="OMA" id="HVVMVSQ"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="26506" checksum="6E0B321607E48818" modified="2011-04-05" version="1">MDTQKQKEQNSSKPTVVLVHGAVEDSSLWTHGVIQGLQRGGFPVKVFSNPLRGLFVDVAYLQSLLDTIEGPVILVSHAYGGAVITQAGDDPKVKALIYAGSPMPGVGESTNDCLERFPGGDFASSVDLIAYTLPDGITGTNVLVKADKYGYLLAADVPQDLLALMIATQRPIAAAALSDVLTSAAWTSKPSWQIRPLLDPVIPQEEFKFEADRAHSTVIELNSSHAIPITYPDVVVDVIEQAARAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L2</accession>
    <name>E8X1L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3236</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581559.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3236"/>
    <dbReference type="EnsemblBacteria" id="ADW70247">
        <property type="protein sequence ID" value="ADW70247"/>
        <property type="gene ID" value="AciX9_3236"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3236"/>
    <dbReference type="eggNOG" id="COG4683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107454_1_1_0"/>
    <dbReference type="OMA" id="EFGPQLG"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="13021" checksum="057451C095F0684B" modified="2011-04-05" version="1">MATEVIVTTEFADWFEHLDEAEQRSVGRVIGLLEERGAILEFPFSSGINGSKFSQMRELRIQHAGEPYRVLYAFDPIRQAVLLVGGVKTGKGNRWYDEAIRLADRLFDEYLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S5</accession>
    <name>E8X1S5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="7" type="ordered locus">AciX9_0927</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579318.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0927"/>
    <dbReference type="EnsemblBacteria" id="ADW67994">
        <property type="protein sequence ID" value="ADW67994"/>
        <property type="gene ID" value="AciX9_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0927"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_2_0"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1384751at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="25257" checksum="53A9FC8092B3B4BC" modified="2011-04-05" version="1">MAISRATKTEKVKFLTKELETSTSAIVGTFKGLTASKDFELRKAIRAAGGSYHVIKNKLAAKASQGSKIEAALQNLKGVSAVAYTSGDPVVLAKALSTWVKDNSEFTFKVGIVDGQVLNVQEITELASMPGKEELFSKLLFLIQSPAQRLATVINATGRDLAVVINQGVEKEKFAAGADAPVAAAPAAAAEPEVAAAHAEEAPTPEEAIAANPASEVDAVAETAQPENGTASQAGEAANADPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T5</accession>
    <name>E8X1T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0937</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579328.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68004">
        <property type="protein sequence ID" value="ADW68004"/>
        <property type="gene ID" value="AciX9_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0937"/>
    <dbReference type="eggNOG" id="ENOG50338CM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187562_0_0_0"/>
    <dbReference type="OMA" id="HEEQTEI"/>
    <dbReference type="OrthoDB" id="1968270at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="10348" checksum="3E3B9FD1587E0953" modified="2011-04-05" version="1">MSVNPVLLIVWAVLAACFMAMLIYRGQLTRYEDEQLFLNDERDINAHEEQTEIVRKVTRLDPIVRILGSAAGLATASVIGIYTWHAYQLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W2</accession>
    <name>E8X1W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2078</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580440.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2078"/>
    <dbReference type="EnsemblBacteria" id="ADW69123">
        <property type="protein sequence ID" value="ADW69123"/>
        <property type="gene ID" value="AciX9_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2078"/>
    <dbReference type="eggNOG" id="COG3753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084747_3_0_0"/>
    <dbReference type="OMA" id="HVEQWAS"/>
    <dbReference type="OrthoDB" id="1984170at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045372">
        <property type="entry name" value="YidB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027405">
        <property type="entry name" value="YidB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20159">
        <property type="entry name" value="YidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140804">
        <property type="entry name" value="SSF140804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="14485" checksum="2D85482607460816" modified="2011-04-05" version="1">MGIFDSLESMATSALASGAGGQNAQAASGLVQELQQQPGGFGALVTNFQQNGMGGLVQQWAAGQTQPASPDEVEQGLGGSGIIDNVAQRTGLSPTMIKSGLAIAIPFIVHHMASNGHITPEGDPTENPNPEPGGLLQSILGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y1</accession>
    <name>E8X1Y1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2098</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580458.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2098"/>
    <dbReference type="EnsemblBacteria" id="ADW69142">
        <property type="protein sequence ID" value="ADW69142"/>
        <property type="gene ID" value="AciX9_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2098"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_0"/>
    <dbReference type="OMA" id="TRPEQEE"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="27679" checksum="A8C9E289AB8D1806" modified="2011-04-05" version="1">MTITTNPPSDQREPQTKPNTSPEVTAARAGQKPGTVYLCGAGPGDPDLLTLRAARLLATCEVILPDDLVSDEILALANPLAEIIPVGKRCGQPRITQAGIHELMLHHARRPKSVLRLKSGDPLVFGRAGEEIDALAAAGIPFDIVPGITAAFAVAASLKTPLTDRAAASKLILATAHHSATKTEPVAWHGAFPPEATLVLYMPGRDFTRLAAELIAAGIPPATPVAAVSRATTPHQHVVSTTLAALPTSQPGPAPLLILIGQAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E2</accession>
    <name>E8X2E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1009</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1009"/>
    <dbReference type="EnsemblBacteria" id="ADW68074">
        <property type="protein sequence ID" value="ADW68074"/>
        <property type="gene ID" value="AciX9_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1009"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067066_0_0_0"/>
    <dbReference type="OMA" id="FGPHCFY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13395">
        <property type="entry name" value="HNH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="358" mass="40050" checksum="6A8C4A9CA7FAB107" modified="2011-04-05" version="1">MPPPTPAQQIKFLTNLQRLLAEGSFTATYKYALLAALADLSVEHGDDSGEPLVFSLFAIAEKLVEYYWRHATPYAGGQETRVLQQSTGSQARIIRLVSEARQSHGVSLASMMRLPGAWNALVRSVVPTLREQPLWRLQVVGLETLDFLYGRSGTKDIELRHGIAYCFRQFFTLVQDLVRAAWLRDVRRLNGEFIGEPTDLRDFLFGAERSALTAAKPVLMELQDGRCFYCAGALIEVRAEVDHFIPWSRYPADLVHNLVLADRRCNSKKRDRIAHADHLDRWTDRNRRDGDGLASAMAGRVVCDLKSANSVAYWSYAQTEDAKGLTWMHGDILGPLSPAWRNAFPDSANEGIVGNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H1</accession>
    <name>E8X2H1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580511.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69195">
        <property type="protein sequence ID" value="ADW69195"/>
        <property type="gene ID" value="AciX9_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2151"/>
    <dbReference type="eggNOG" id="ENOG5030ZTQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115354_0_0_0"/>
    <dbReference type="OMA" id="MGHNSLH"/>
    <dbReference type="OrthoDB" id="1737840at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025673">
        <property type="entry name" value="PCYCGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13798">
        <property type="entry name" value="PCYCGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233607" evidence="1">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16070" checksum="80E6F2F18B22B689" modified="2011-04-05" version="1">MRSMKKVLGCLVLGLVALAASAQWSNPAEDIPAYNAQAPSRALPPVLSGAQLTGPYFSHPYQVTAYKMAAKIPGVLHQQPCYCRCDREMGHNSLHSCFEGTHGAACSTCMKEGVFAYQQTKLGKTPLQIRAAIEKGEWMNVDLEKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J0</accession>
    <name>E8X2J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580530.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2170"/>
    <dbReference type="EnsemblBacteria" id="ADW69214">
        <property type="protein sequence ID" value="ADW69214"/>
        <property type="gene ID" value="AciX9_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2170"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016729_0_0_0"/>
    <dbReference type="OMA" id="WALSPFM"/>
    <dbReference type="OrthoDB" id="1419511at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234299" evidence="1">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="447" mass="44010" checksum="B990B52B55A3F7AF" modified="2011-04-05" version="1">MIRNITFSLALTTALLLTGCGVGPVSTTLVPAPVSIAAGQAKGIVMGGQQPVAGVALQLYAVGVTGYGSAATPLFTPGAVKTTPSGNFTFPSFTCPDANSMIYLVGTGGQPIAAVGSIAAITNTNLALMAGLGTCSNLGGNAFIDMNELTTVASVWALSPFMTGISNIGSPANTGNPLLPSAGLVNAFASINKLVAVSTGTVVASTTTVTLPTAKINTLADILENCVNSAGSSYSGCSGLFSLAGGSATTDTVTAALFIAHNPSLNVASLNQMRSASPVFQPPLAVSSPPNDWSIVLTYKGGGLNAPQAIAADQSGDVWIANSGNSSVSEFSPTGVALSPTAGFTAGGIDSPFALAVDQSGFVWVANSGNNTITKLTSGTAGTAFGSSATLNTPKGIAIDGTGNVWVSNSGGASVSAYTPSGTVIAGSPYQGTGFVQAPVAIAVNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P4</accession>
    <name>E8X2P4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3332</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3332"/>
    <dbReference type="EnsemblBacteria" id="ADW70341">
        <property type="protein sequence ID" value="ADW70341"/>
        <property type="gene ID" value="AciX9_3332"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3332"/>
    <dbReference type="eggNOG" id="ENOG5030NB9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076730_0_0_0"/>
    <dbReference type="OMA" id="WISGHEK"/>
    <dbReference type="OrthoDB" id="1577144at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="30912" checksum="F22C23D67E9E3642" modified="2011-04-05" version="1">MARPEQGPELGKCALCLRPDVALQRSHLMPKGVYKRLRGSTGSTHPTRILEGRAVQTSAQTWAHLLCGDCEQRFNRLGEKWVLTHGLQQNQVTFPLLAKLLTMEPTEFDEGLDAWLLRPGKQEWFEPDALAYFAVSMIWRASVSDWGQPTVYPLKLGPYREDLRRFLLGDTAFPTRAYLSVCVRTPGPVSSLTYLPETMRQDGVTSHQFLIPGFFFILWLGGNLPEHLADGCLVAGKGHPMFVGSYLEDTFGRRVHKLRHQQPPDRSRRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q4</accession>
    <name>E8X2Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3343</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581663.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3343"/>
    <dbReference type="EnsemblBacteria" id="ADW70351">
        <property type="protein sequence ID" value="ADW70351"/>
        <property type="gene ID" value="AciX9_3343"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3343"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_1_2_0"/>
    <dbReference type="OMA" id="NIFWFLP"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="39235" checksum="A61CAA6B1B147012" modified="2011-04-05" version="1">MRYGFWLPVFGGWLRNLDDEQMETSWEYTSRLVKRAEQIGYDLTLIAELNLNDIKGVDAPSLDAWSTAAALAAVTESIEIMVAVRPTFHNPALLAKQAANIDQISKGRLSLNVVSSWWRDESTKYGITFDEHEMRYARTSEWLDVVDGCWSQQGFTHQGPLYDIRENVLSPKPVAGRRFTGMPAAGATKGGRPTLYAGGESETAKNLIAAKCDAYLMHGDPPEVVGKKIADMRERREKLGLAPMTFGVAGYSIVRDSEAEADAEVARITNVNASARGYANYQQWVTGSKLEQKISLEDYSVSNRGLKAGFVGTPQRVKERMEEFAAVGVDLVLLQSSPQAEEMERFAAQVMVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R1</accession>
    <name>E8X2R1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="12" type="ordered locus">AciX9_3350</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581670.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3350"/>
    <dbReference type="EnsemblBacteria" id="ADW70358">
        <property type="protein sequence ID" value="ADW70358"/>
        <property type="gene ID" value="AciX9_3350"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3350"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_1_0"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="43179" checksum="DA1A8E0E3AE8F231" modified="2011-04-05" version="1">MPKTDHPQNSSRFVRACLRQPVDRTPVWFLRQAGRYMPEYMAVRKHHTLLEICRTPEIAAEVTITAAERLGVDAAIIFADLLLPFTPMGLDFEFVAGEGPVVNTPIRTYEQVQALRTDRSEDLIYVSQSIEKVAKHFASPRPPEAGQTDGDQLGIIGFCGAPFTLASYMIEGGSSRNYIEAKKMMYASGATTESRHSERSSEPPYLHSSTEPQSPMETTGSAAWPLLMEKLVTVLTAFAAQQVEAGADVIQVFDSWAGALSVEDYRQFCLAPTKQLVENIRNMGVPAIYFGVDTASLLPTMTETGADVLGLDWRIPLDEGWKSVGTAHAIQGNLDPIALFAPQEVLHARVKTILQQAANRPGHIFNLGHGIVPGTPVENVIQVARWVHELSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X5</accession>
    <name>E8X2X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen triple helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1046</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1046"/>
    <dbReference type="EnsemblBacteria" id="ADW68109">
        <property type="protein sequence ID" value="ADW68109"/>
        <property type="gene ID" value="AciX9_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1046"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462922_0_0_0"/>
    <dbReference type="OMA" id="DEYIKGY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="589" mass="55134" checksum="278200C2A52E7A2A" modified="2011-04-05" version="1">MFQGASYASLTGANHGNTPGASPAFWGVLTAPGPQGAAGVAGPQGPVGAQGLLGPVGPPGERGDQGLQGIAGQAGAQGLTGATGAQGLSGPAGPQGVPGPVGVTYRGSYSFVTNYALADGVSYGGASYVSLVSSNHGNTPDQSPQAWGLFAAGGSVGAAGSAGPAGPVGPQGQQGQQGFTGAAGVAGVAGPVGPAGLNYLGVYSSTANYAVADAVNYGGATYVSLVAGNHGNTPGLSPDDWQAIAAQGTAGAAGKDGSPGLVYQGGYASAHTYGLNDAVSYLGGSYISLAAGNTGNTPSLAPAFWGVLSAQGAAGAVGATGASGKDGSVGVAGPAGAIGPAGPAGIAGAAGINFRGGWNGGTHYSVNDGVTFGGATYLAQSSSMNVEPDADASVWAVLAAAGGAGATGASGPAGAGATVQVGTVTTGAAGTAASVMNSGTSSAAVLNFVIPQGASGSGGGGGGSAAASTSGIPFASMYHSVSYAALYYSVNNGSQAATETAAVLSWSPGGCSATTLTVFSEQSGTIAVTLRAGATPATMANTSLSCTVGQGQSCTANGLATVPVGGFVDLMVTQADGTPSPVWSAVSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X367</accession>
    <name>E8X367_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2253</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580607.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2253"/>
    <dbReference type="EnsemblBacteria" id="ADW69291">
        <property type="protein sequence ID" value="ADW69291"/>
        <property type="gene ID" value="AciX9_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2253"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_0"/>
    <dbReference type="OMA" id="NMGQATP"/>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="15"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="21715" checksum="A37E9299E9F328EF" modified="2011-04-05" version="1">MTFLHQHASEIARLTFEHLWLTFFAMALAAAVGIPTGILLTRHERLAKPIITIANIIQVIPSLALFGLLLPVPWLGENAARLAILALTGYALLPILRSTYAGIRSVDPALIDVAAAMGMTPTQRLLKVELPLGASVILAGLRTATVTCVGVATIAAAIGAGGLGELIFRGVASVDNGLVLAGAIPAALLALIADSALGLLEKKLTIRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A8</accession>
    <name>E8X3A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3403</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3403"/>
    <dbReference type="EnsemblBacteria" id="ADW70409">
        <property type="protein sequence ID" value="ADW70409"/>
        <property type="gene ID" value="AciX9_3403"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3403"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137365_3_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13132" checksum="34F136C12F656B62" modified="2011-04-05" version="1">MANKTTPYREALLASLADPIEAKHYLNATLEDNPEGFLKALRNVAQARRMAQVAQDAGLTRESLYRTLSEEGNPTFETLNSVLDVLGLKITIGVRAKSLSRRAVGTSPAKASTVLATAHAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H6</accession>
    <name>E8X3H6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
            <ecNumber evidence="2">3.5.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579490.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1104"/>
    <dbReference type="EnsemblBacteria" id="ADW68167">
        <property type="protein sequence ID" value="ADW68167"/>
        <property type="gene ID" value="AciX9_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1104"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_0"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="22908" checksum="5D40986E2E309402" modified="2011-04-05" version="1">MTINQQTDALLLIDLQPDFMPGGPLAVAGGDEILPTINALARRFDHVLLTQDWHPPQHISFSSSHPQRKPYEVIQAPYGPQTLWPDHCLQHTPGAALHPALEIPHAELILRKGFRREIDSYSAFLENDHITPTGLAGYLRERNLKRLFIAGLAYDFCVRFSAIDGKALGFETIVLEDASRPVNLPNSVAETNTAFAAAAIPRISSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J1</accession>
    <name>E8X3J1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxyl-terminal protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1119</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1119"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="ADW68182">
        <property type="protein sequence ID" value="ADW68182"/>
        <property type="gene ID" value="AciX9_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1119"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_2_1_0"/>
    <dbReference type="OMA" id="VDNVNTD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="61685" checksum="9ECE9CB95B85378C" modified="2011-04-05" version="1">MFAWILFFTLYFKETDLMAPTTRRTLFSVTVFLATCGIAGSFISQKVSAQTAGDESTLRDSLKSFTSVYSVVEQNYAEKMDTDRTDKAIYDGAIPGMLHTLDPHSNFYDPKAYAQMREDQHGRYYGVGMTIQPQLIDGSMKILVLYPFEGTPSFKAGIKPGDMILSVDGKTTDGMDSTAVANMLKGPRGTHVLVTMMREGKDKPMQFDLVRDEIPRPSVDLAFLIRPNVGYMHVTNFQETTGREVGDALDKFQASAPLKGLVIDLRANPGGLLNQAVDMADKFLKKGQIVVSQHGRVAQDQVYTVSRGEQGAEYPVVVLVNRNTASAAEIVSGALQDHDRALIVGETTFGKGLVQTVFNVSQNTGLALTTFHYYTPSGRLIQRPYDNMSLYDYYYVRDASNPKSNANREVKLTDAGRTVYGGGGITPDDHIDQIKGNHFENTLLQHYAFFNFSKKYLSTHSVAKDFEVDDATLTDFKAFLKAKNVDYTEADFTANLSWIKDSIKSDLFTSQFGQMEGLKVRAEWDPQIQKALGFLPQAQALLDNPKGKAAATTTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W6</accession>
    <name>E8X3W6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3469</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581785.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3469"/>
    <dbReference type="EnsemblBacteria" id="ADW70474">
        <property type="protein sequence ID" value="ADW70474"/>
        <property type="gene ID" value="AciX9_3469"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3469"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_0_0_0"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="39199" checksum="E2E7D8E02DE4A21A" modified="2011-04-05" version="1">MARRPKQNPQDLIDIPTWLRGLPKAELHLHLEGTVTPETLVELSRRHDLEPLTLETARAIYVYSDFQAFLMAFKAVSERLQTPEDYEFITYEMIKALAAQGVVHAEVYISWGILLRFKPQLAIPSIMDAVERARLRAEAEFGTTLYWLIDAVRHFGLEEAATVFRLAAELRLIYPSIIGIGIGGDEARGPAEPFRDLYAEAKAAGLRLTVHAGESTGPVHGPASIWSAINIGAERIGHGLAAQHDADLLSILAERQIPIEINVTSNLRTGCCESLEAHPVREYFEGGLFLTLNSDDPPMFGSDLLGEYILVQEQFAFSLDEMREFAANSIEASFLPPERKLKLMADVERYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X452</accession>
    <name>E8X452_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578441.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0021"/>
    <dbReference type="EnsemblBacteria" id="ADW67112">
        <property type="protein sequence ID" value="ADW67112"/>
        <property type="gene ID" value="AciX9_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0021"/>
    <dbReference type="HOGENOM" id="CLU_2034783_0_0_0"/>
    <dbReference type="OrthoDB" id="2207502at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="12785" checksum="D38E14FFF32E4884" modified="2011-04-05" version="1">MTIQPPIPPAQTVAIPLTPEVRAAYQALYDANEALIENTTDPGFLAALNDVSTNVGNILTKDNLYRIEANNALFQALQQQINSTNASLLALKKQIQAVASHVSEAGTVLSAIDKVVSLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D1</accession>
    <name>E8X4D1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="11" type="ordered locus">AciX9_1195</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1195"/>
    <dbReference type="EnsemblBacteria" id="ADW68258">
        <property type="protein sequence ID" value="ADW68258"/>
        <property type="gene ID" value="AciX9_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1195"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_0"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="32741" checksum="1E8D4D25C10FD9A9" modified="2011-04-05" version="1">MGEDAAKVGKVAKGPDMRVTVCGVELASPVIAASGTFGYGVEFEEILSFERIGAFVTKGLSREAMAGNPTPRIIETASGMMNAIGLQNMGVKAFVEGKMPRLREIAGAVVIANVFGFTVEDCLEVIRVLNDAPGISLYELNASCPNTAHGGMVFGTDPTLLGNLVGKCAKLAARPVVVKLSPNVTSIALMARTAAGAGAQGLSLVNTFLSMAIDPETRRPRIANVTAGLSGPGIKPIAVRMVYEAAQAVRIPILGMGGILNASDAVEFMLAGATAVQVGTASYADPRAVENIANGLRRWCEKHSVGKVSSLTGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G2</accession>
    <name>E8X4G2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1226</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579612.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1226"/>
    <dbReference type="EnsemblBacteria" id="ADW68289">
        <property type="protein sequence ID" value="ADW68289"/>
        <property type="gene ID" value="AciX9_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1226"/>
    <dbReference type="eggNOG" id="COG3585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107520_1_0_0"/>
    <dbReference type="OMA" id="ELQCGPF"/>
    <dbReference type="OrthoDB" id="1698303at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="4">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15052" checksum="89611D582D8DA660" modified="2011-04-05" version="1">MPALDPMLTPREAARLLGISYPTIKQWILSGKLATSPTPGGHHRIAESTLKPFLASDAAKPAPESRERYRRVSGRNQLAGKVVSIRVEGLLAEVILAVAGSHITAIITASAVHELRLKKGDSAAALIKSTDVMIERLTDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J1</accession>
    <name>E8X4J1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580717.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2364"/>
    <dbReference type="EnsemblBacteria" id="ADW69401">
        <property type="protein sequence ID" value="ADW69401"/>
        <property type="gene ID" value="AciX9_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2364"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056160_3_0_0"/>
    <dbReference type="OMA" id="AFETIHY"/>
    <dbReference type="OrthoDB" id="847145at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="284" mass="31000" checksum="DE5D21808D9E89DC" modified="2011-04-05" version="1">MQTGQPSRTAFAAAAHRAAHQLLEKGSLFPDPLAIRILGQSPEVIAQEAEATPSRARMRLFIAARTRFAEDALAAAVAEGVTQLVVLGAGLDTFAYRNPYPTLRVFEVDHPATQTWKRQRLAEAAIPIPAALTYAPVDFEAQTLAQGLETAGFDPTQPTFFTWLGVVPYLTPEAMDATLSFIASLPAPAHVVFDYSDPPETFTPELREFHNLRAARVAALGESWINFPSAEALHPRLRALGFTKIEDLGPPEISARYFPNRTSTPHAKGAHMLYASKNKSNNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K6</accession>
    <name>E8X4K6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ordered locus">AciX9_2379</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2379"/>
    <dbReference type="EnsemblBacteria" id="ADW69416">
        <property type="protein sequence ID" value="ADW69416"/>
        <property type="gene ID" value="AciX9_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2379"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_2_0"/>
    <dbReference type="OMA" id="IPQSMKW"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="241"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="58539" checksum="23D93A260D7A0F49" modified="2011-04-05" version="1">MRSIRPQAWILVVFSAILQTFCFPVAGQISFSRAGICWFALVPFFIALLIPDKSGKSLRPLQGAALGYLCGVLWYVGNCSWIYQTMYLYGGMEKPVAFLILILFALYLGLYHALFALLLTFFRGRFRSMRNVLLLAPVLWVAVELARARVTGFPWDLLGNALIDHAWMTKLAPLGGVMLMSFVVAMANACFTGIALKPGSTWYGKCGSIVTIAYFLQLTGTPGRTMPSAGNQTAVMVQENLSVGATSKSEKPLTREYELQQFSELSLHPQLSSVLSGQRQQATVVVWPEAPAHLQTNDPAFRAAMSDLARRANAPVIAGSLGVDFDNKPARGYYLYDSAALFDKSGSYQGRYDKIHLVPWGEYIPYKQFFSFAQKLTEGAGDMDPGTTRSVFTTNGHTYGVFVCYESIFGDEVRQFVKSGAEVLVNISDDGWYGDTGAPWQHLNMARMRAIENRRWVLRSTNTGMTTAIDPYGRYTETPRHVRVAYALPFAFESGLTFYTRHGDWFAYLCAVVALAAVGFSLKPRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N4</accession>
    <name>E8X4N4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="6" type="ordered locus">AciX9_2407</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2407"/>
    <dbReference type="EnsemblBacteria" id="ADW69444">
        <property type="protein sequence ID" value="ADW69444"/>
        <property type="gene ID" value="AciX9_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2407"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_0_0_0"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5 6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="101" mass="11108" checksum="70A0D12414A4B70D" modified="2011-04-05" version="1">MIVPISAYLILAAILFSIGIAAFLIKRNVISVFMSIELMLNAVNLTFVAFAHRWHAVSGQIFVFFVMVVAAAEAAVGLAIIIAIFRTRQTLNVDQINLMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q3</accession>
    <name>E8X4Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3537</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581853.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3537"/>
    <dbReference type="EnsemblBacteria" id="ADW70542">
        <property type="protein sequence ID" value="ADW70542"/>
        <property type="gene ID" value="AciX9_3537"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3537"/>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020365_1_1_0"/>
    <dbReference type="OMA" id="KFPREDW"/>
    <dbReference type="OrthoDB" id="1309809at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="487" mass="53316" checksum="F6F538A58BA97726" modified="2011-04-05" version="1">MLLVIVVLQIVLLGGLVVLLMRRTSAPVLDARQAALPDQITGLQARHEALESALRSGLSEIRREAGTEALTTREANARASAELRGEVTGTIATLGQTVKTELAGFRSDNTQAAGKLQADVHAQHEAIGQKLTAAASEARLQQEGAREALHRRLTELGESNAAQQEKLRGTVGESLDRLSSANEKKLEEMRVTVDEKLHATLHTRLTESFGQVTDQLNKVHTGLGEMSKLSEGVDGLSRIFTNVKSRGGFAEVQLGMLLKQMLAPGQYIENATVKPGSAERVEFAVRFPGHSGERLMPIDAKFPREAWERLENAYESNLPDAIAKAGTAFETAIRTEADRICGKYINQPVTTPYAVMFLPTEGLYAEVIRRDALQAEIQSKCHVTIAGPTTLSAILTSFQMGFHMLALQEKGDEVWKVLERTKTEFKTFETLMGSMENQVQTVQNTIQKLGVRTRAINRSLKDVSEVDSAQPFLVEEIVPRLAAGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T1</accession>
    <name>E8X4T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581881.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3566"/>
    <dbReference type="EnsemblBacteria" id="ADW70570">
        <property type="protein sequence ID" value="ADW70570"/>
        <property type="gene ID" value="AciX9_3566"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3566"/>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144805_4_3_0"/>
    <dbReference type="OrthoDB" id="1897062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10674" checksum="9AE4168FD6CA9225" modified="2011-04-05" version="1">MPEPSVLHITLSEETLEFVRSKVASGKYQSESDVVTDCLDVFRQDEEEHKRFEQEVVGPAYDELKANPSHSISIEEVERSLEARRQARQLANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V9</accession>
    <name>E8X4V9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3595</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581909.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3595"/>
    <dbReference type="EnsemblBacteria" id="ADW70598">
        <property type="protein sequence ID" value="ADW70598"/>
        <property type="gene ID" value="AciX9_3595"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3595"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801147_0_0_0"/>
    <dbReference type="OMA" id="TENGHCM"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="189"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37509" checksum="5DBB638D60C72085" modified="2011-04-05" version="1">MFAGPTSAQNAAPAAAAKPAYESDPKYQAAFADGRKLTHDRQYGFAKDAYNKANKIAGGACGPCLNSVYSLDFGMHDFKDAISTANKLQAIAATPRDKSLAEGMLGDAILKQAGDKPKPAQLDAAHTALQSALTDFPKNNPARWSDACVLARMGKNDDASKQFSECADRASATDPMKIRAQHFAENPALSLSKMAPAFEVTALDGQRFNLDNMGGRVVLIDFWATWCGPCNEELPHMKKIAKEFANDPLVIISISWDSDDAKWKSFIAKNEMTWTQYRDADHKLSDEFGINAIPHYFTIDSDGVLTAEMLGSGSDVEGKLKKLIKRAREANPTTQVTAQLSGQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y8</accession>
    <name>E8X4Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578509.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67180">
        <property type="protein sequence ID" value="ADW67180"/>
        <property type="gene ID" value="AciX9_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0090"/>
    <dbReference type="eggNOG" id="COG1751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150585_0_0_0"/>
    <dbReference type="OMA" id="HNKEMAM"/>
    <dbReference type="OrthoDB" id="1423591at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26370" checksum="BDBC36480304888A" modified="2011-04-05" version="1">MMSRGDKIQTFDGEGRENLPNVVKNIKNYMRGLISNGIPYPVKVIFFTLQGEGPMLAYNQLSGLDLKIIAVTFPATYTIKLKTGGTYPPDMPEKVRKFFDGVEIPIIRARLPFDDISGAELHNKEMAMLKSALSVFGGSMPLAIQAVLQATDSGHIPSGEEVIVATSDTALLVTASTTKDFLDKTNGLVVNEIICKPRNFNISRPQPKPSPILQMPSPFSEHPTILEGEVSQTGRTHLVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X533</accession>
    <name>E8X533_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0150"/>
    <dbReference type="EnsemblBacteria" id="ADW67225">
        <property type="protein sequence ID" value="ADW67225"/>
        <property type="gene ID" value="AciX9_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0150"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2553494_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="9503" checksum="D65412EC6226DA65" modified="2011-04-05" version="1">MHEEDPSRSVVLNDGFSPPPGSAAQAWFEPCNDTMHRSDEEAWGGWWNNHQGAGDQWYDDFYKDSEHFTYRQPLKANRSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C7</accession>
    <name>E8X5C7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ordered locus">AciX9_2439</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580790.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2439"/>
    <dbReference type="EnsemblBacteria" id="ADW69474">
        <property type="protein sequence ID" value="ADW69474"/>
        <property type="gene ID" value="AciX9_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2439"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_0"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="595" mass="64328" checksum="9A91A63AC9FDEFD9" modified="2011-04-05" version="1">MTANGWFQILFFFALVLVSAKPVGVYMARVFERERTLVDILFRPVERALYKLSGIDESYEMRWTEYAISMLLFSLVTLLLTYMIERLQQWLPLNPQHLANVSPDLALNTAVSFTTNTNWQSYVPEATMSYLTQMLTLAYHNFFSAAAGMALAIALIRGIARKETKTLGNFWVDTTRASLWILLPGCFIYALLLVSQGVVQNFRPYDQAKLIQPMTVTTTGADGKSVTQTITEQSIAQGPVASQEAIKMLGTNGGGFFNTNSAHPFENPTPLSNLLQMFSIFLIPAGLTVTLGHMTKKPAHGWAVFAAMATLFFVGVFVTYYAEAQPNPLLHTASMHIDQQVSATQSGGNMEGKEVRFGIANSALFATITTDASCGAVNAMHDSFMPLGGLVPLVNIMLGEVIFGGVGAGLYGMLIFVILAVFIAGLMVGRTPEYLGKKIESFDVKMAMLYILIFPLSILGFSAVSLMMPNLGISALGNGGPHGLSEILYAFTSATGNNGSAFAGISANTHWYNLSLGAAMLIGRFLMIVPMLAIAGNLAQKKLAPPSQGTFPVDTPLFTVLLIGTIIIVGALTFFPALSLGPILEHLLLNAGKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I8</accession>
    <name>E8X5I8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3612</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3612"/>
    <dbReference type="EnsemblBacteria" id="ADW70615">
        <property type="protein sequence ID" value="ADW70615"/>
        <property type="gene ID" value="AciX9_3612"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3612"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124812_0_0_0"/>
    <dbReference type="OMA" id="RYTRVYQ"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234416" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="171" mass="19062" checksum="070841D4415B4935" modified="2011-04-05" version="1">MSRRSFILALLLAAFITQMTPRAEASHKAHTLKKKDYKHEIEGLEEQWRVAQIAGDVTAMDNLLSDDYVGITINGMVNTKAQQLDRIRTRALTVTRMDLSDTKIKLVGSIAVVTCRAEIEGMNDGTPVNGTVRYTRVYQRLSSGTWKITNFEVTRVPHSHRADVASAAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N9</accession>
    <name>E8X5N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3665"/>
    <dbReference type="EnsemblBacteria" id="ADW70666">
        <property type="protein sequence ID" value="ADW70666"/>
        <property type="gene ID" value="AciX9_3665"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3665"/>
    <dbReference type="eggNOG" id="ENOG502ZB0K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873648_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043769">
        <property type="entry name" value="DUF5715"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18979">
        <property type="entry name" value="DUF5715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230753" evidence="2">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="35325" checksum="A23CFEC0866562B8" modified="2011-04-05" version="1">MRVFAHKLALFAVFATAGAPAYAHPHHPAAAKSHGQRQTTHAAKKTETQLHHRHKPPMPQQDRVNPVSGRHHKPAPSARTIARSTPIESTPEPIYTHHNRKLHHTPTPEVATVKSPVFMVVPPMKGSHEILIHQNLMADSDGLTRVQDDSDLDRMRADRSLVIIPEALGLQADDRLPANRRYCRPWTAQFLAAMARAHYERFHSPLQVNSAVRTVEFQQKLLRINGNAAPAEGDTASPHLTGQAVDIAKHGLSATEIAWMRGYLLPLVQQGKIDVEEEFQQACFHISVYRRYVPAPVAPRDIAQTHRGAATVLAAAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q4</accession>
    <name>E8X5Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581990.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3680"/>
    <dbReference type="EnsemblBacteria" id="ADW70681">
        <property type="protein sequence ID" value="ADW70681"/>
        <property type="gene ID" value="AciX9_3680"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3680"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_0"/>
    <dbReference type="OMA" id="HEPNWQL"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="50462" checksum="90387297F1E516F2" modified="2011-04-05" version="1">MLRQFFSGGSLRRNAAEFMLQNAREYGDLNHYRIFGRNIYQLNHPDLIADYFLKDAPKHHRNMVMQSAREVLGHGLLTSEEPLHMRQRRLAQPAFLRERIAAYAEVIGNKTLELTARWKPGTITDLHPEMLELALRIVGKCLFDLDAFDDVTAIASAVDSFMSFMPLSFLPFARQIQRSPIPAMRRLERGKAHLDQLIYRMIAERRADPTDRGDLLSMLLNATEPEGDGSEASGMTDQQLHDECVTVILAGHETTANALSFALHLIAHDPAVQERLHEESTRVLGNRNPVAADYPWLPFATQVFAETMRLYPPVWVTGRTCAVPYTIAGYQIPVGATLLAPQYAVHRDPRFFADPERFDPSRFKPEKKAGLPRYAYFPFAGGSRQCIAEGLAWMEGTLVLAVIARDWRLTPPTGSAPRPAIKPAISLRPSHGTPLLIERRIPSYRGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R0</accession>
    <name>E8X5R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion protein, VC_A0111 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3998</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572706.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70794">
        <property type="protein sequence ID" value="ADW70794"/>
        <property type="gene ID" value="AciX9_3998"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3998"/>
    <dbReference type="HOGENOM" id="CLU_048238_4_0_0"/>
    <dbReference type="OMA" id="RAFFDVF"/>
    <dbReference type="OrthoDB" id="1688251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="40105" checksum="C171F80358218E93" modified="2011-04-05" version="1">MATESGHEGSALETDRAQFEAVRKMLDDEPFRVRFFQAVRMLQRMEKGRGTVGGFSQPQDETLRFSSLPTFGFPPSEIYDLERMSSGQLKMTVQFMGLTSALSALPSMYTEQALTRIREKDRAMVEFFDIFNHRILSLFYRAWEKHRYYIGYEAGLDDKLSLRLLDILGLGTEGLRNRARLSDKTYIYYAGLLGRHIRTADSLRQILEDFFDVPVQINQFAGTWRSLPKENMTFLSGSGRMSEQLGLGVVTGEEVWDHHGRIQISLGPMRFDRYQQFLPGETGYNELVGWMQFYSDGAYETQVQLILDKQDVPECELDGQGQSTPRLGLVSWLKTRPRMTDAGEATYLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V4</accession>
    <name>E8X5V4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4043</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572750.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70838">
        <property type="protein sequence ID" value="ADW70838"/>
        <property type="gene ID" value="AciX9_4043"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4043"/>
    <dbReference type="HOGENOM" id="CLU_1052768_0_0_0"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234427" evidence="1">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="264" mass="29437" checksum="51D9C76F6528E11D" modified="2011-04-05" version="1">MRLASFVAAAMLCVATSAHAVDARAAIAIARQRVEATDSRASGHLVRVNANGKRVSNAFTLEAHWFPGVLRALIEIVPPRTPAENANQDARVSILLEMRPNGQNTIQIFRPHESAPALLPFDKWSESVFGSDFNYEDFLQPEFYWQNQTILRSDKFGVHDCDVLKSVPEGSNRSHYVEVQTWLDHNINYPVYVEKTPKDAAGVKEFTYSGLTQSGGVWAARQVGVKVRGRPGLTLLLIEHGSTRANLNIRDFSPEKISHFEDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X625</accession>
    <name>E8X625_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar motor switch protein FliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572821.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70909">
        <property type="protein sequence ID" value="ADW70909"/>
        <property type="gene ID" value="AciX9_4129"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4129"/>
    <dbReference type="HOGENOM" id="CLU_1118280_0_0_0"/>
    <dbReference type="OrthoDB" id="1875967at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="2">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="28400" checksum="194A8B4F0D1160C1" modified="2011-04-05" version="1">MQAPEISSTKTLESLFCGALAKPFSDACTSTWHLALSTEPVPTAPALEDAVIFRCTFSGEVSGQGFALLRHAEVVTLGLQDMLDDTDAFGDEHAMALSSIFEASCNELCQHLSQKSPVTVQVERMSAPELPTDRLAELFLEAEGTKIRVSILLFFDQQLVTTYQNASAQTFSFPEVTGTSTSNLNLVLDVELNVTLRFGQRQLSLREVLDLTSGSVVELDRQVDEPVELVLDGKVVARGEAVIIDGNYGMRITQVLQQVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X643</accession>
    <name>E8X643_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_4147</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="14 15">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
            <plasmid evidence="15">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572839.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70927">
        <property type="protein sequence ID" value="ADW70927"/>
        <property type="gene ID" value="AciX9_4147"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4147"/>
    <dbReference type="HOGENOM" id="CLU_028108_1_1_0"/>
    <dbReference type="OMA" id="NYEVNRI"/>
    <dbReference type="OrthoDB" id="167675at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0614">Plasmid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="46"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="243"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="525" mass="56126" checksum="D97BAA1D4F892D25" modified="2011-04-05" version="1">MAGFDQIFVQAKQFWATRTQSQRLFLGVGAAATVGLLALFANLMVTPDYKPLISGLESADAQAISADLTAKKIPFQLSPDGKSISVPADQVDAARLDVASNQSTHSGRLGFEIFDKVSWGQTEFDEKVNYQRALEGELERTIVTLGGVKSARVHLVMATDSVFLDREKSAKASVTLKLNRGGLSHDETASIQRLVSGAVEGLKPTDVSIIDADSNQSMGAAGDGAMGEEGAERQLTQRLMATLTPVVGGDHLRASVNVEYDPGTTEENQEKYDPAVSVPLTIQRSDESTGAGAGVGGVPGTTSNVPQNKANVPPPVGEDSAQVSKTENATYGVNKITRHSLEPAGRIKRITAALVVDDSVKRKLGANGKWTEIRTKRSPQELKQIETLAQNAIGLDTTRGDVISVENLAFDRPDEPDVAPVTALDRARKGVSDFSSVVRYAMLLILFVLAYVLMIRPVQKKVLAVSVQLPQQPLLPEMAAALPLLAPSTSMARALALKEQVVQQVKSEPEGSARVVQAWLRGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X652</accession>
    <name>E8X652_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4156</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572848.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70936">
        <property type="protein sequence ID" value="ADW70936"/>
        <property type="gene ID" value="AciX9_4156"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4156"/>
    <dbReference type="HOGENOM" id="CLU_016890_3_0_0"/>
    <dbReference type="OMA" id="DEKNRPM"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="123"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="34005" checksum="26BF439C092E1EE8" modified="2011-04-05" version="1">MADELQPIIVIKKKGAHGGHHGGAWKVAYADFVTAMMSLFIVLWLMSSTSKQTQEEIAGYFNDPKGTSTKHGTEGKESKKEEKESKKDDLAALKKDLMRAIEKIDSLNRLKKQIEMTVTEEGLRIELVEDAKGTFFETGSSKPTPALEEILKVLSEQLKSLPNSISIEGHTDAQPYATATVYGNWELSTDRANVARREMQENGIRTDQVSQVRGFADQRLHVPEKPLDASNRRISLVVQNFALRKPDSKGLTKTDLTKTNVAEAKPEAAPEAKPDQPKAEEAKPTAMALPPVAAKSPVGLLGRMKGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X686</accession>
    <name>E8X686_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S11 D-alanyl-D-alanine carboxypeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4191</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572882.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70970">
        <property type="protein sequence ID" value="ADW70970"/>
        <property type="gene ID" value="AciX9_4191"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4191"/>
    <dbReference type="HOGENOM" id="CLU_031960_9_2_0"/>
    <dbReference type="OMA" id="FVTRFMV"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="33373" checksum="38772F73ED687C91" modified="2011-04-05" version="1">MPGPGWYFVWFLMLGSAVAQSTPLEGRLREIAAAHHGKVAVFAENLKTGETVGLDADKVVQTASVIKLTILFDAMEQVRAGKVKLDDAIVLKKSGQVGGSGILQLFDTPLTLTLRDVLMLMITQSDNTGTNLAIDKLGLANINGETRALGLKNTWLYKKVFTPATEPMPADQKIYGLGKTTGREMAKVLERIYKCQFITAPKPGDEALCTEMLGMLNKQGSRDGVPRYLNNDSAVGNKTGALEAVRADAGIVSTKAGPVVMCLFTYENADRRWTADNEGEVTIAKMSKAIVEAWSPEGMDAAGYKVSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K7</accession>
    <name>E8X6K7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3876</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582177.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71157">
        <property type="protein sequence ID" value="ADW71157"/>
        <property type="gene ID" value="AciX9_3876"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3876"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_3_0"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="486" mass="52043" checksum="639083FE55524DAD" modified="2011-04-05" version="1">MTDTMNKARLSEDREIETDLPQRMDRLPWSSWHVRIITALGTSWLLDGLEVTLVGSLSGILESKQGLSLSDPQVTAAATTYLAGAVIGALLFGHLTDRLGRKKLFLVTLATYSVATVCTAFSQGFLFFAVCRFFTGLGIGGEYAAINSAVDELIPGKVRGTVDLFVNGTFWVGASVGSVTALVLLGGSLFPQATSWRYAFGIGGGLGLLVLLLRLAVPESPRWLMLRGREEEAETIVRDVEQRVTTSSGKALPRPEGEKLKITVRDHTPWKEIFVNMLGENRQRSFLGLALMIAQSYFFNAVFFTYALVGKRFFHVPDQKLPLQLLPFAIASFLGPFVLGPLFDRIGRKPMITATYAIAGILLGAICLPFATGSLRLKGLGICFSIIFFVASSAASAAYLTVSEIFPLEIRAFAIALFYAIGTCIGGVGAPLLFGVLIHTGSKPAVAAGYALGAVLMVGAAVLEAFIGVEAAGKSLESVSKPLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q2</accession>
    <name>E8X6Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicupin, oxalate decarboxylase family</fullName>
            <ecNumber evidence="5">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3926</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582220.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8X6Q2"/>
    <dbReference type="EnsemblBacteria" id="ADW71202">
        <property type="protein sequence ID" value="ADW71202"/>
        <property type="gene ID" value="AciX9_3926"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3926"/>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_0"/>
    <dbReference type="OMA" id="HPNNDEW"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="84"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="261"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="45994" checksum="BD2DDA4FA2071B12" modified="2011-04-05" version="1">MSDNQNNPLSRRKFLGNTSAALAAFGALQVASGQEAVPIRSKDHHLINETETQPKNKMLDDQNPSSNWPPTTDAGGQQPFKYSFSLSHKRIEGGGWTRQVTVRDLPISKKMAGVQMRLIKGGIRELHWHVGAEWAFMIGGSARITAVDQQGRAFVDDVNEGDLWVFPGGIPHSIQGLGPDGCVFLLVFDDGNFNEFETFLLTDWLHHTPPEVLAKNFDVPASTFANVPPKELFIFERDLPRPLAEEKHQVEAVTGPVPNTFAFFTSKMAPTKVTKGGSVKIIDAKNFPASNIAAAIVTLKPGGLRELHWHPNEDEWQYYVKGSGRMSVFAAGGRARTMDFQAGDVGYIDKSTPHFVENTGDEDLVFLEVFPTPHYEDISLAEWLAHTPSRLVNEHLGVGEDFLNKISKKEAVVDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R6</accession>
    <name>E8X6R6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M14 carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582234.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71216">
        <property type="protein sequence ID" value="ADW71216"/>
        <property type="gene ID" value="AciX9_3940"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3940"/>
    <dbReference type="HOGENOM" id="CLU_011471_0_0_0"/>
    <dbReference type="OMA" id="HDNNRDW"/>
    <dbReference type="OrthoDB" id="96337at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230291" evidence="2">
        <location>
            <begin position="32"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="60"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="865" mass="95113" checksum="E3B041EF1369942E" modified="2011-04-05" version="1">MADQKKIPGRTAFRWGLLGLLSLASSTSAIRAQQVTTPEQAFGFAPGTDRKLADWKELTTYYQTLAKQSKRIKYEELGKTTEGRPFVALTISSAENMAHLEDYRKIQLALADPRVTTEAQAKALIAQGKTVLVVTCNIHSTEIASSQSAAVFAYRLATEDTPEIKAILDNVIIVMVPSQNPDGEQLVVDWYKKYLGTPYEGTSPVVLWHHYTGHDDNRDWYAFTQVETQLTTDKVINAWRPQILYDIHQMGAYGPRIYLPPWVDPIDPNIDPLLVSSMNSLGTETALEISETGKQGVLIDGVYDMWSPARHYMAYHGALRVLTESASVNIASPIDIPFEKLDRGIGYDAKVAAWNFPDPWKGGTWRLGDIVNYQIDAFFSIAKNAANNRARYLTDFYHINQHATEQKYGGPYAYVIPAEQVDHAATARMIDILRRGLVEVTQVSAPFTAGGKTYSAGSYVVVLAQPYGPFAKTLLEVQHYPNIELYPGGPLRRPYDVTAQTLPMLFGVNADAVADKFAFQGKRVSWATATGHFEASRSAPGYLLEDTDNAGYYALFALLKDGVKAYRLTSGNESAGTIYLPRQDGLDVKLKAVTAKFAIEIKPLTTKPTGTALLVTMPRIAMYQSWVPSMDEGWTRWIFDQNSIPYTRVVDADIRKGDLKSRFDVLLLPDEAPRAILHGSGGREEGGGGPKPPPEFTGGMGDDGWANVKEFTEGGGTVVALNKASQLYTTQNSAGVKNALDGIANKDFYIPGSILEIAVDPQNPIGFGSKPKVPIFFELSPVFSLDDAKNSIATYTSDKPLLSGWLLGGKYLAGKTALVDLKQGKGHVVLFGFRPQYRAQSEVTYKMLFNAMLLSNSTATDLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X731</accession>
    <name>E8X731_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71140">
        <property type="protein sequence ID" value="ADW71140"/>
        <property type="gene ID" value="AciX9_3857"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3857"/>
    <dbReference type="HOGENOM" id="CLU_665264_0_0_0"/>
    <dbReference type="OMA" id="CIMIASA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="413" mass="46027" checksum="45D2ED301C3C3166" modified="2011-04-05" version="1">MSSARLDAWLFSFYTILLIVLPTGNFFGLNVKMVAFVPLFFVMLFRAIGKRTNPYWMLSCLVGVPLYFCYWVFPGQTGQYDLSLAFAQYRNLLITLAGCWFALVYISEDRTRSLSFIRLVLWVVAAMSVLKVLVTVYCLMRGIPVSTIMNGIGNFFGIKLMSFELDEADPDAVGSRIMFTSDLLLAPCCFAAIAMRRRLGFGRLTMFTLLLLYVVSVIFGFSRFHWAFCGLAIVLGFAVAKGEKWILLLLVAAVVLSALFIPAISGILALRFASNLVSDSDAPRHVQIAALSRFFWNAPLLGHGWGTYARDCIRSTDFPYSYEVELLALLGQIGIVGVLSLFLLAGRYFKSLFQWRKNNVIFRMAMLALLTTFIVGGTTNPMLLTSISSVSYALFLMLGDLSTEPALQLSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X757</accession>
    <name>E8X757_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4339</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573010.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71291">
        <property type="protein sequence ID" value="ADW71291"/>
        <property type="gene ID" value="AciX9_4339"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4339"/>
    <dbReference type="HOGENOM" id="CLU_1209319_0_0_0"/>
    <dbReference type="OMA" id="HIPFQPF"/>
    <dbReference type="OrthoDB" id="2128105at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234478" evidence="1">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="25047" checksum="E4429DD58B70C41D" modified="2011-04-05" version="1">MKQLLRTTAITLVALGASAANAQFYKDVFKPYGASISVGGTGLFSTPLDSNPTSGTFNVPRVGGGTLSETVSNQHQDTTWSAGFITSLQFHPKPWAGLELNYGFSRFSEVYSYNYSSTPTVQSSKVTTDMHEYTAAYQFHPKHIPFQPFVNVGGGYVEFVPGTASGQFRETGLLEAGFDIPTHTKHIGFRIEGRSLYYRAPNFENSAISTRSWRVTTEPSISTYYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C2</accession>
    <name>E8X7C2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573075.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71356">
        <property type="protein sequence ID" value="ADW71356"/>
        <property type="gene ID" value="AciX9_4406"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4406"/>
    <dbReference type="HOGENOM" id="CLU_073333_0_0_0"/>
    <dbReference type="OMA" id="MFRHQGK"/>
    <dbReference type="OrthoDB" id="1751020at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="25953" checksum="FD1E0CFFC7D5DC69" modified="2011-04-05" version="1">MPFSYLRVLTGHERTQKSNRHLARYLAFIAGAVNAGGFLAVRQYTSHMSGIVSAMADNLALGSLSLLFAGFIAVFSFLAGATCTSLMVRWARQRSLHSEYALPLILESLLLFAFGFTGHVFEDKEVLGTVALLCFTMGLQNAIVSKISGAVIRTTHLTGMVTDVGVKLGRMLYGQLSGTPPLANVDVRKLSLLGSLIGLFFVGGVVGALGFHHIGFKFTIPVAVTLLILAALPALDDLRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C4</accession>
    <name>E8X7C4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4408</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573077.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71358">
        <property type="protein sequence ID" value="ADW71358"/>
        <property type="gene ID" value="AciX9_4408"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4408"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="IVCMESE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="290"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="57598" checksum="C70FDC4698699659" modified="2011-04-05" version="1">MKFADKYESEPAAIIRKSGAAIFLADSLEQQDVLMALGDLKIATTILGPQDREFHHLRNFEFIVADHLIAKELVLFFEEHEADADGISPAVIAVTSNELEDPSILTQEVCNFDGVLKFPMTGTEISARLSVIMHAHCAFAKRYSAAWRELRLNRRIFRSVTAGISVASATLPDLPIVYVNPAFEEMTGYSRAEVQGRNCRFLEGNERSQPALAIVRDALKNRRKGLAVLKNFRKDGTPFWNELSLSPIMDDEGQLTHYVGIQTDVTQRVELESALRESEKLAAVGRLASSIAHEINNPLTSVMNLIYLAQGTDPSQETKDYLVTADRELRRVKLITEQSLRFFRQSTKAQPTTAAELLEPILDLYQSHATNARVTINLRERPSRPIVCMESEIRQVLSNLVGNAIHAMQERGGQLSLRSRETRNHGRGRDGLLFTVADSGTGMSAEILSSIYKAFYTTKGIGGTGLGLWISSEIVARHRGNIRVKSTQSPGSSGTVFEVFLPFDGIAPYREGVDISQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G8</accession>
    <name>E8X7G8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TrwB_AAD_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4456</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573121.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71402">
        <property type="protein sequence ID" value="ADW71402"/>
        <property type="gene ID" value="AciX9_4456"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4456"/>
    <dbReference type="HOGENOM" id="CLU_405395_0_0_0"/>
    <dbReference type="OMA" id="YDPACEF"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TrwB_AAD_bind" evidence="3">
        <location>
            <begin position="225"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="696" mass="78073" checksum="C2AE0FA64A14556F" modified="2011-04-05" version="1">MATQWGRRETAVWPPHMPIYTYLGVASALLCTLIFVWQNYSFWQTPLQQSYATEYLRAQISSQFELHGSYRLIYLSGNHRTRLAIPDDFENGVTTLPGGSSVPVVLSRTARAEGFEFFYRAPTLSYKDASLYSWFRSNVFKGKGILRMYAANLCEGVFVLFAILFYTVRLDMKRLKEMKYGRRLKGPVMHSTHSFNAAVKGDGIGIVTTDAAKSFRFPFRAATPATLRIPLTSEAQHIEIIGDTGSGKTTIILQMLQQIQLRGEAAIIYDPACEFVKRFYDARKDVILNPLDARCPYWGPSEELRSKAEAKAIAASLYQPTSDKKGEFFTETPQKIFAHLLTFGPTPQELIKWMSDPAEIDARVQGTELAAIIAPGAQQQRAGVLASLGLIADSLRMLPTKEQAKNRTWSATEWAEKREGWIFITSKAAEREALRPLHSLWIDLLVLRLLSAPTATQRPVWFVLDELASLQRLPQLHTAITENRKSKNPLILGLQGKAQLETIYGHLAEVMLSQPATKIFLKTTEPKASEWVSKAIGNVEIERMRETHVHGSREGKSFTIDRQTEPLVMDSEISGLADKHAFLKLGNNVARFAFTYCDMPEIAADFVPRAVLEDELAFDPLTLKKKYTPIPTPTYLPEEAVLTEDPEEEKEDPEIDEEIEPTDEAEPADVSAELRPESAPGLFPDAESSYLTGAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I8</accession>
    <name>E8X7I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4476</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573141.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71422">
        <property type="protein sequence ID" value="ADW71422"/>
        <property type="gene ID" value="AciX9_4476"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4476"/>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_0"/>
    <dbReference type="OMA" id="HTANQKF"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="29709" checksum="F94270AE94828F19" modified="2011-04-05" version="1">MTALSRDGIRVLIVEDEAPARQRLSDLLSQDPEVSSVQEVGDGETAVRVILSERPDLVLLDVQMPELNGLEVVEAVGSENMPLTVFVTAYDQHAIQAFEANALDYLLKPFSDERFEAMLDRVKRRRDDLHLRQFGQSVAQVLRSQATEARHLYRFAIKTDGITKFVRVKDVDWIEAAGVYVTLHTSGKEMLYRTSLADLEHRLDPMRFLRIHRSAIVNIESIVQLEALSHGEFEVLLKDGSHPRVSRSYRNSMEKRLGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J8</accession>
    <name>E8X7J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4486</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573151.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71432">
        <property type="protein sequence ID" value="ADW71432"/>
        <property type="gene ID" value="AciX9_4486"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4486"/>
    <dbReference type="HOGENOM" id="CLU_120900_1_0_0"/>
    <dbReference type="OMA" id="MWADEER"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233774" evidence="1">
        <location>
            <begin position="26"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20625" checksum="3F402E30E30E51F9" modified="2011-04-05" version="1">MFATRHFVIATVLLTAACMSLTVNAQAAAKPDPLSQSFDKVLSQFALQFLAVSKAMPSEKYDFTPATLRLAGADYKGVRTFAAEVKHVAEMNFVIYSVMSGLKPDMDMDSIRDLKSKDEIISALSRSFAYGHRALLTLNAGNSGEMPPDSHGMTKAGIAAYVMVHDADHYGQLSEYLRMNGIVPPQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y2</accession>
    <name>E8X7Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71566">
        <property type="protein sequence ID" value="ADW71566"/>
        <property type="gene ID" value="AciX9_4636"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4636"/>
    <dbReference type="HOGENOM" id="CLU_139085_0_0_0"/>
    <dbReference type="OMA" id="RNTAHSH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="15043" checksum="C6F2273D39AB2832" modified="2011-04-05" version="1">MARAKNINNDAASNQEIPLKTQLDSRSPNRWARQLTQQKMRNFVRTIAPSLIALSFATAAHAQGTMDFSQAKTLMQSFQTFAVYAGAVICFGSLIFAGIRLMGGRFQDAIPGLFGALFGAGVLGWGAGWISSLTGQSVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y6</accession>
    <name>E8X7Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573289.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71570">
        <property type="protein sequence ID" value="ADW71570"/>
        <property type="gene ID" value="AciX9_4640"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4640"/>
    <dbReference type="HOGENOM" id="CLU_849322_0_0_0"/>
    <dbReference type="OrthoDB" id="1074108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006881">
        <property type="entry name" value="RepA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04796">
        <property type="entry name" value="RepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="385" mass="42672" checksum="A4D6DF7E2F245999" modified="2011-04-05" version="1">MTRKAKSLVVREYHFVDPETGGKSLITPDEKGHLVYTDTAGKAHRLPEALIPDELKPVRSLQASAASAEIVPAPRAKRDNKAERASATGNRALRAAEVRIALEADNTDVMQLAQALILCGLPYRMTSERQISRKARLGDGSTVTVTFTALSADADMPFGSDRTLLHYLLDKAVKSGNRYVSWDTAKEFMEQMGMKGTGGKAYADLRERFDRLRGLGIFVSRKGAGRNETSNMSAISRSRLPSSLDLNAENVGQSALPLSESVRYGVEIGTELYNDLIKHHVPVPTELLIQTRGNAQLQDICIFLFWRCFAANSPSVIPWASVREQLGSADSNPRRIKVRFAEAIKFFRTFWPEMQAESRPEGVWVAPPRDGKYLLPQGKGTRRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X822</accession>
    <name>E8X822_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4677</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573324.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71606">
        <property type="protein sequence ID" value="ADW71606"/>
        <property type="gene ID" value="AciX9_4677"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4677"/>
    <dbReference type="HOGENOM" id="CLU_104070_2_0_0"/>
    <dbReference type="OrthoDB" id="1613304at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="17069" checksum="DF01865F843A19A8" modified="2011-04-05" version="1">MLIQKLEPLFFKENTHLVEVLDKSNGIWTAEKSRGYGILVISYNNLRFGIPLRSHIKHQARFLTDGTKGLDYSKAVLLTKDEYISTTPFMIPPDEYVKIKDRTHHINGQFAKYVEKYVTAVQKNDENVLRNYKFSTLQNYGLELGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X846</accession>
    <name>E8X846_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71630">
        <property type="protein sequence ID" value="ADW71630"/>
        <property type="gene ID" value="AciX9_4703"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4703"/>
    <dbReference type="HOGENOM" id="CLU_2879574_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="6719" checksum="CD3A89E3A7C83CE2" modified="2011-04-05" version="1">MTDAPSSLVSAVDIMLGDFIAFCASFLIFGDVIAAGALGISQFYVLEPSEFQKRCANEIRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV72</accession>
    <name>E8WV72_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0173</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578575.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0173"/>
    <dbReference type="EnsemblBacteria" id="ADW67247">
        <property type="protein sequence ID" value="ADW67247"/>
        <property type="gene ID" value="AciX9_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0173"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_1_0"/>
    <dbReference type="OMA" id="VNLDMPI"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="277"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="521" mass="55779" checksum="777C7BA734C56BE7" modified="2011-04-05" version="1">MMTKWLVLGVLAGVAFGQGMKAHPRDGEIHDADTKAWWHTTEDLSSDAMEGRDTGSAAYARAAQYVADRFKGAGLVPAGESGTYFQDVPLHELEVTREGTTFTLVRAGSAEKSLRFLEEIDVTPGAGLPAMVEGGLVFRGYCGKDEVGDLTGKIAVCFGARRPGVTSGRDRVAAVRGAGAVGMVSVDDPAFTIEPPRWPDAYSRSVTIAGGTRAGAGSFVAMRLSAPAFATMLEGSGQDAKGILALGGASKALPSFDLNEKLRVTTHTAQKEYSSPNVLAVLPGTDPVLKSEYIVIAAHLDGYGHGTPVAGDSLYNGTLDDAAYVALILQFAEDQKALGKAGGLKRSVLFCAFTGEEKGLLGSTWFTQHPTVPKEALVGDINLDQLRPLFPLKILTALAVDESTIGATAKSVAGPMGIEIRADREPERNLLLRADHWPFMQIGVPSIGFIFGYDPGTDAERRYRQWYTTQYHRPQDDLTQPMDFDAAAKFDTFFYTLTRRLANDAARPAWTAGSKYAATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV97</accession>
    <name>E8WV97_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0198</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578600.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67272">
        <property type="protein sequence ID" value="ADW67272"/>
        <property type="gene ID" value="AciX9_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0198"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141551_1_0_0"/>
    <dbReference type="OMA" id="HESMQPA"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229941" evidence="1">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="61"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="14544" checksum="C069F3A7F1F2C1E3" modified="2011-04-05" version="1">MKLAAILLALIPLAAQAQATLPTSTVYPYDHLTPKKSPNGTESRPVLSGTLLSGEAVGLHESMQPAHAEPVPLHVIQHSEIIMVQEGTLGFEHDGKTEIVTAGGTIYVALGTLHRLKNMGEGPARYFVVQIGGDTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF2</accession>
    <name>E8WVF2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1340</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579723.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1340"/>
    <dbReference type="EnsemblBacteria" id="ADW68400">
        <property type="protein sequence ID" value="ADW68400"/>
        <property type="gene ID" value="AciX9_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1340"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_7_2_0"/>
    <dbReference type="OMA" id="IWAPWNL"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="196" mass="21654" checksum="171CDC5F089F7770" modified="2011-04-05" version="1">MAKQSYYNAAEHISPETAADPYLRPAFSLGNRLRRLVWNICWLLFYRISPRPFHAWRTMLLRLFGATMGPHCHFYPASKVHSPWNLICADGVAAGDGVEIYNPAPMRFGSHAILSQGAYLCGATHDFDDKAFPLLAYEMEIGAYAWICARACVAPGVKVGEGAVLGLASVATRSLDPWTVYGGSPAVRIKDRQRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF6</accession>
    <name>E8WVF6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Capsular exopolysaccharide family</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1344</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1344"/>
    <dbReference type="EnsemblBacteria" id="ADW68404">
        <property type="protein sequence ID" value="ADW68404"/>
        <property type="gene ID" value="AciX9_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1344"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_2_0_0"/>
    <dbReference type="OMA" id="ETQYALM"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="7">
        <location>
            <begin position="392"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="CbiA" evidence="6">
        <location>
            <begin position="544"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="753" mass="81894" checksum="866F3B51F15EA499" modified="2011-04-05" version="1">MSSDNPYSNPGPGMSQAQQPTFVAPSNDTTLSEALITLRKRRMVLIIAVVLGTLFGFYKSVTQIKPYEAYGRLEVNTGASNQFKLSPFSGLGDDPQQKMMSEIAIITSDTLLTTVAKEMNLANNPTFLSVKGPIPHSSMEDPRVRQTIVGILQKNLKVTLVPKTDIIRIAYSSLDPKLSADVVNKVIADYQQRSYETRFDSTKRVSQWLSGQLDDLKRQVETSQEQVLDLGKKLGTLGFDSTHNQIASSLEDLAKASGTAKLARIIAESRYRMLNGMDPNAIEGSIDAGTTATTGGATNGLANLRSNLATARATYAELTATLGPNHPQVKAARAQIDEFQHAVEAEQNRLLTQAKETYLIAKANETQTTAALEAEKQDAYSLRDAQVEYTLRLREFESNRTLYEGLLQKLRTAGVEAGLESSEIDIIDQAVPPSDPQSTPQSTIILTYFAVSLVLGTLLAFLLESLDTGLRSVAEIEAITELPSLSIIPRARRATPEQLAAMSTVERNINVLTQPKSQFTEAFRSLRTALLLASTGKEPRLLLFTSATPSEGKTTAASNLAVILAQGGTRTLLIDADLRRPNVHHRFGLNGKLGLSTILSGQTTLENSVQTLKEVPTLDILASGPVPPFPTEMLSSASMAELIRHASEIYTHIVIDSPPILSVTDGIILSRQVDVCVLVVRHGKSSKHVVRRARDLLVRSGAPIAGIVLNAVDLNSPEYYGYYGYSGYSYSSLDTAGWDAKSESGKTRKRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG9</accession>
    <name>E8WVG9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1357</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579740.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1357"/>
    <dbReference type="EnsemblBacteria" id="ADW68417">
        <property type="protein sequence ID" value="ADW68417"/>
        <property type="gene ID" value="AciX9_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1357"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1401643_0_0_0"/>
    <dbReference type="OMA" id="DEDETPC"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="21788" checksum="28D62106943504DE" modified="2011-04-05" version="1">MPGQTLDARLVQIVDAALADATLRGGSHLACRAGCSQCCVGVFPIAQQDAERLRQGLHALSGSDPARAERIRLRVLDALTRLDPWFPGDLATGVLNEDHESAILFEEFANDEPCPVLDLTTGTCDLYEARPILCRTFGPPMRTPEDNLGTCELCFIHASTDEIAACELDPAVPEIQEASDDAYNEQAGCSGETLLAYALRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK3</accession>
    <name>E8WVK3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2500</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2500"/>
    <dbReference type="EnsemblBacteria" id="ADW69532">
        <property type="protein sequence ID" value="ADW69532"/>
        <property type="gene ID" value="AciX9_2500"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2500"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="CFLKAYN"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="201" mass="22601" checksum="E57375F94E2E6F8B" modified="2011-04-05" version="1">MFAKASLMSDSSILSSGICVGERGSVISELDDIDGLVRVYRPRLLRYVAFSINDQDLAESITQDCLLKAFNARGSFRGDCSVSTWLFGIANNLIRDNLRTKKFQFWRKARATALDVTEMASFLPSHASSAEARVLAEERLRQVRDVVEELSVNQRRVFMLRFTEELDLDEISEITGMPINTVKTHLHRAISAIRTKLGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW2</accession>
    <name>E8WVW2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582030.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3720"/>
    <dbReference type="EnsemblBacteria" id="ADW70721">
        <property type="protein sequence ID" value="ADW70721"/>
        <property type="gene ID" value="AciX9_3720"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3720"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131565_1_0_0"/>
    <dbReference type="OMA" id="PLIAWFK"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="13931" checksum="46B308D41BCF69FE" modified="2011-04-05" version="1">MLAQASVVGFIPVHDFDLAEGFYAGKLGLTVASRDPFALVLTAAGDVMIRCVLTPEFKPQPYTVFGWEVLDITVSAKALNAAGVETLRYPWFEQDADGVWTAPGGAARVAWFNDPFGNVLSLSQHKAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX8</accession>
    <name>E8WVX8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3736</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582046.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3736"/>
    <dbReference type="EnsemblBacteria" id="ADW70737">
        <property type="protein sequence ID" value="ADW70737"/>
        <property type="gene ID" value="AciX9_3736"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3736"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058197_0_0_0"/>
    <dbReference type="OMA" id="WHFPVAI"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="218"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="36112" checksum="8A6D3221D0720AA1" modified="2011-04-05" version="1">MGLIGVIAQHGYAIVAIVMFLAAAGLPLPTSIVLLGAGAAAHNGLKLDIIFPLAWASAVLGDTLLYFGGRYTGWWLLAGMCRFSINPEACIFSSSAYFYRRGSKTLLFAKWVPGLASMAAPLAGSLNMKFSRFFRLDAAGNLFYVSVWVTAGYLFSRFLNEIMGWIQRVGHAFLLIGALLVAGYAVSIVVFSIRARKYNKIDKISAANLQERLQNLHPDKLVIIADVRSHGYYDPGMQRIKNSIRVEPTRLKEELIALREFMAPECEIYLYCSCIRDTTSKRVAHMLEQENCKTQVIDGGLKAWVKAGGELELVPLADIQHLPRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW05</accession>
    <name>E8WW05_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0237</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578639.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0237"/>
    <dbReference type="EnsemblBacteria" id="ADW67311">
        <property type="protein sequence ID" value="ADW67311"/>
        <property type="gene ID" value="AciX9_0237"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0237"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_12_0_0"/>
    <dbReference type="OMA" id="WLFRAAR"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="22127" checksum="03BBA719A25E1AC3" modified="2011-04-05" version="1">MSSSELSLAEQDDFIAETLRRDESRLRSFIGKRVFDDGDAEDVLQDVFYELVQTYRLMKPVEQVTAWLYRVARNRITDLFRRQRPDSLNEAEYKGEESEVLLDSLPSESDGPDAVYARNLLFESLDDALEELPEEQREVFIAHELMGRSFKELAEETGVSVNTLLSRKRYAVLHLRERLREIREEFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW34</accession>
    <name>E8WW34_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase, hydantoinase/carbamoylase family</fullName>
            <ecNumber evidence="3">3.5.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0266</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.87" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578668.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0266"/>
    <dbReference type="EnsemblBacteria" id="ADW67340">
        <property type="protein sequence ID" value="ADW67340"/>
        <property type="gene ID" value="AciX9_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0266"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_6_1_0"/>
    <dbReference type="OMA" id="VGEFRIE"/>
    <dbReference type="OrthoDB" id="829830at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050538">
        <property type="term" value="F:N-carbamoyl-L-amino-acid hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="45230" checksum="3AA9A13031560535" modified="2011-04-05" version="1">MSGTKANAGVEPARVLADLRELKALTGDEHGAQRVAWTPVWLKARSWFEGKLDEIAKTAPRLERRYDAAGNLWATLPGESAQALLMGGHLDSVPNGGWLDGCLGVLTALEVLRGMAEVYEGRPPMTIRVVDWADEEGARFGRSLFGSSAFAGAHSIAADRGRTDREGMTLEAALKACGYDVERIGEAAVEQKDAAAYLELHIEQGPVLEGLGLPLAVVLGTKGVERHAITFHGQEAHSGSTPMTVRRDALAAAAKLALEIRPIARKRSHDSVATMGSVKTFPGIVTAVVGRCETTLDMRDLYPEILAGMFADARAASERFAAEEGCTVEWQRIWSIEPIPFDPKLIELATEAVKEVAGAAPLLPSGPLHDAAEVSRAGIPTVMVFVQSLNGLSHNSAEDTKEEHLAMAVKAFGGLAARTLAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW61</accession>
    <name>E8WW61_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cellulase</fullName>
            <ecNumber evidence="10">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0295</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578695.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0295"/>
    <dbReference type="EnsemblBacteria" id="ADW67367">
        <property type="protein sequence ID" value="ADW67367"/>
        <property type="gene ID" value="AciX9_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0295"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_2_0"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229981" evidence="9">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="40767" checksum="ACBFFAEF97981066" modified="2011-04-05" version="1">MKTFAALALLLAASLASAQQPDRTLTLLQRLADAPGPPGAEEAVRAIMVPEMKPFITEPLRYDGTGSVIAQQGTKGPRIMIDAHMDELGGMVRRVTPNGFLTMQMLGGWLDQALVDQRWIIIGSKGPVHAVTGIRDIHIVPAEERTRVFSRDSLYLDVGAKNAQEVFAMGVEAGDPVVPDSPFTVMNGTQNYLGKGWDDRIGCAVLLEAMRRTSAMPHPNQLFYVATTQEEVGLRGAKAASQLVKPDIGIAIEGGITGDTAGAHPEESQVKLGAGPGMFLYDSSTIPNRKLVAFTRAAARSASLPLQADLVQGYGDDSAEMQASSGGTPTINLVVPVRYTHSHNGIVNRQDFDRTVDLVVAMLMKLDAAAVADLRDFTPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWD1</accession>
    <name>E8WWD1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1461</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579834.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1461"/>
    <dbReference type="EnsemblBacteria" id="ADW68514">
        <property type="protein sequence ID" value="ADW68514"/>
        <property type="gene ID" value="AciX9_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1461"/>
    <dbReference type="HOGENOM" id="CLU_171854_8_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6234" checksum="AF375CE469588C83" modified="2011-04-05" version="1">MDMCKILFGDLIGDDTGQNVLEYAFIAALIALGAIASMSSLSSKLADFFAAVGTRLTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE2</accession>
    <name>E8WWE2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2580</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2580"/>
    <dbReference type="EnsemblBacteria" id="ADW69606">
        <property type="protein sequence ID" value="ADW69606"/>
        <property type="gene ID" value="AciX9_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2580"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067316_1_1_0"/>
    <dbReference type="OMA" id="YDFPKVH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045738">
        <property type="entry name" value="DUF6088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19570">
        <property type="entry name" value="DUF6088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21082" checksum="745A1AE9D24C946F" modified="2011-04-05" version="1">MESILQRVTALPEGAPVSAKMLLHLGTRPAIDQSLSRLARRGRLLRAGRGVYVSPVVTRFGSSAPLAERLIEELSAQRGETIVPSPATSANALGLTTQVPVRTIYLTSGKTRKLTLGKQVIELQHAPSWQLTFAKEPAGEIVRALAWAGPERVDEVLKEIESKVPKGDLKKVNQHISLFPGWLATALSRSAFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK5</accession>
    <name>E8WWK5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2644</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2644"/>
    <dbReference type="EnsemblBacteria" id="ADW69669">
        <property type="protein sequence ID" value="ADW69669"/>
        <property type="gene ID" value="AciX9_2644"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2644"/>
    <dbReference type="HOGENOM" id="CLU_2770114_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7755" checksum="6029FBB5AAA388BD" modified="2011-04-05" version="1">MHPIRTDPTIHFIVIPMQNLSEAFVCNASIPPGRKKPTISLYYEQTPPKTARNSHAINPSHYAPSFINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX17</accession>
    <name>E8WX17_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1525</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579897.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1525"/>
    <dbReference type="EnsemblBacteria" id="ADW68578">
        <property type="protein sequence ID" value="ADW68578"/>
        <property type="gene ID" value="AciX9_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1525"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_4_0"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="22446" checksum="7B8D01E9D5D9BF6E" modified="2011-04-05" version="1">MIHEILAVGPLRCNCSILGDEISREAIVVDPGDDISRIMALVAKHNLTVKQILITHAHIDHIAGAQELKRLTGAPILYNQRDLPLVAMMDVQAGWVGMKTPEVAAPDQDLADGYVFSIAGLNGIAHHTPGHTEGSVCLHLPEQTLLLAGDTLFQGSIGRTDLPGGDLKTLLRSVHNKLLTLPDETLVIPGHGDSTTIGEERESNPFLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX60</accession>
    <name>E8WX60_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2678</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581017.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69702">
        <property type="protein sequence ID" value="ADW69702"/>
        <property type="gene ID" value="AciX9_2678"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2678"/>
    <dbReference type="HOGENOM" id="CLU_908413_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="306" mass="33290" checksum="3A0F1BE33E46BA75" modified="2011-04-05" version="1">MMEIARTEQRRNRWILLATYLYLGLLFAYALHGAYTESGLPGLVVDSQMRLLGFASLKMTLVLTMLVGCIPLLALVTVFKKIAFAETKAFLVYANPRNASFPNPMTWGFVFAIPAGMALLGAVIAAVLYVGHKQEEAKPVDQVDLATAPAGPDQHQGYISLNGNVPKKFIVTSKAGELWDAFAPVVESNWTQAAPVRYLVHCRTASSEHGSPILPAPLTDGVPYNFTGTLSHGISGTVARKLLDEKINVPDGLAVVEWGDIPSQRADPFYVDVFITIAVTVAVSGMTFLMLCFARWQNARVLPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX93</accession>
    <name>E8WX93_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2711</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581050.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2711"/>
    <dbReference type="EnsemblBacteria" id="ADW69735">
        <property type="protein sequence ID" value="ADW69735"/>
        <property type="gene ID" value="AciX9_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2711"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_0_1_0"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="363" mass="39883" checksum="C1028D85EDC5E6D8" modified="2011-04-05" version="1">MAKRVGVDKWLFGVVLLLTLFGLVMVFSASAVVAKSQYGSPYYFVVKEFGFAVAGLVALAVLMQVDYRRYNSPRVVFPAMAVTTLLLVSVFAMHALNNTHRWVKFGVFTFQPSELAKPMSVLFLAYFLQTRIHKMDDWKGTVMRAALPPLVFVGLILKEPDLGTALVCAGVTVAMLYLAGLQMKWIGLAAAAASPVMFYMLWMVKWRRDRLIAFTNPEADPLGKGFHIMQSLIAVGTGGVRGLGLMEGRQKLYYLPEAWTDFIFANISEELGLLGALALVALFVTFGYRGLRAAYLSTDPFARFLAFGLTTAILIQAFFNMSVALALVPTKGITLPFVSFGGTSLFFTLAGMGVLLNITREID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB7</accession>
    <name>E8WXB7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0378</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578778.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0378"/>
    <dbReference type="EnsemblBacteria" id="ADW67450">
        <property type="protein sequence ID" value="ADW67450"/>
        <property type="gene ID" value="AciX9_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0378"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077340_0_0_0"/>
    <dbReference type="OMA" id="RRIEVGC"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26306" checksum="86ECC2B392AFAEF8" modified="2011-04-05" version="1">MTHAGPFRNAILQNLSQGSLARLQLRPVTLEVRHPIETPGSPIRHIFFLETGIVSVTTQFKDGSEVEAGMFGCDSLSGISAFMGTRESLNAAYIQIAGHGYLSSVAHAAAEFHLGGRFQAFALRAVQAQLLQSMQSAGCNATHDVEQRLSRWLLLCADRTETDTLALSHEFMSDMLGSRRSTVTVAAGHLKDLGYIEYTRGSIRILNRTGLESVACECYRVLRNHLHDITQYDSGLATPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM4</accession>
    <name>E8WXM4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1587</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579959.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1587"/>
    <dbReference type="EnsemblBacteria" id="ADW68640">
        <property type="protein sequence ID" value="ADW68640"/>
        <property type="gene ID" value="AciX9_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1587"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084442_0_0_0"/>
    <dbReference type="OMA" id="QRIDTFG"/>
    <dbReference type="OrthoDB" id="1903369at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="287" mass="30834" checksum="1EEDE91E2778733B" modified="2011-04-05" version="1">MPTDHLPTRPDTTPEEKKPREGGFALALGVHAGIIALVIGYAYLRPSTKRWGDESPIAGSIQASMVTALPLPPRPKPIEESVLATEKPSIAPTPPPPTPIPPKAKAEPVKPKAEPPPKPKEVLIPTKATPPKPTPKVAERETPEPPRRAPATPPPPTPKATTGETSATAIPQSTTQLKNGTSAITVEERSFGNRYAYYIRLISQKVNEQWLQQQQQVDARSSNGKRATITFTINRDGTPTEARVNTRSGSSSLDAAALRAIQSVDGFGPLPQGDHISVDFSFDFHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP4</accession>
    <name>E8WXP4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chlorite dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1607</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579979.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1607"/>
    <dbReference type="EnsemblBacteria" id="ADW68660">
        <property type="protein sequence ID" value="ADW68660"/>
        <property type="gene ID" value="AciX9_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1607"/>
    <dbReference type="eggNOG" id="COG3253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076582_0_0_0"/>
    <dbReference type="OMA" id="RYTMWSV"/>
    <dbReference type="OrthoDB" id="1616312at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="285" mass="32791" checksum="E404D4A59405A88F" modified="2011-04-05" version="1">MADFIPPKNEVPERRVTEKAIASASGERPAYRPEGAGVEPVARPASPYGAHKEGPPAKRQIVCFSFYKVQPKWRRLPAHEKQAHKDAFVEVLNRWNKPGEFLSLTYSTVGTRGDVDMCVWSIGYAIDELNQMRSELMSTPLGGYLDSPHNFLAMTKRSQYQIDRPDESEGEGRGAIRPGGQKYIFIYPFWKTRPWYLLSATERKRLMDEHIRIGLMYPRVKLNTTYSFGIDDQEFVVAFETNFPEDFLDLVQQLRETEISLYTLEDTPIFSCVRLQPMEMLNRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR0</accession>
    <name>E8WXR0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="2">3.5.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.52" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581070.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2731"/>
    <dbReference type="EnsemblBacteria" id="ADW69755">
        <property type="protein sequence ID" value="ADW69755"/>
        <property type="gene ID" value="AciX9_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2731"/>
    <dbReference type="eggNOG" id="ENOG502Z8PR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011027_2_1_0"/>
    <dbReference type="OMA" id="WTGGWSN"/>
    <dbReference type="OrthoDB" id="300719at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PTHR31104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230432" evidence="1">
        <location>
            <begin position="29"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="572" mass="61085" checksum="A2F82A01059CA970" modified="2011-04-05" version="1">MSTSVRFRAAIFQTVIAGAFCAQGIAGAQVVTVPTTPVVGSSNPATAEPPVTRPTTKPCTVSLYSNEAFNDYSAHPVSYTPPAGCKGPWAKVVLSLDFTVTAGRQFDRTASLYLGNANIFYGTTAEPRTALSPSWHVERDVTDLSALFKTAQTGNAIVYNIFNSTYNGGIYGNATLQFYPADLRNLPPEVPDMVVPVSGTNSPYELDSTSSELKTTVTLPRNLTKAYLDVMAQSQSNDEFWYLGVPNDVSSELETGGGTAFRETEVTIDGKAAGVAPVSPWIFTGGIDPYLWEPITGVETLNFKPYRVDLTPFAGMLSDGKPHVVGISVYNANSYFLATANLLLYRDKLRAETGGDVIENTLFSAPVPSVVENLTTANGAVTGTVDVASKRTFVVKGYVNTGLGRVETTVESTVNFDSNQKFNVATSGVPEIQNINQTSTVDSKTTTRLGFLAEQTATHWAFPLKLDYSFVQNTDGTYTQVVSSDQQHEVSESKGINGFSLASSSTVEEVKTSDALVYNSSLSAVDSVGPTASSASYVSKDSTGNCFSRELTSAARVLTAVQDGKGCPAKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV0</accession>
    <name>E8WXV0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2771</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581110.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2771"/>
    <dbReference type="EnsemblBacteria" id="ADW69795">
        <property type="protein sequence ID" value="ADW69795"/>
        <property type="gene ID" value="AciX9_2771"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2771"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_1_1_0"/>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="404" mass="43257" checksum="4EA953910251BF4C" modified="2011-04-05" version="1">MALSGNTADFGASEGRLGWLAMALTPGLGPTRIGRAVALMDGDAGRIFDMPLTELEGFRLPAKSAQFIADGRARAEAEKEWKRVQEAGATLLTPDDEAYPERLREIYDPPAVLWVRGDVGLLGRAGIAVVGTRSPSPYGAGMAEMLSRDLANRGVVILSGMARGVDTAAHKGALAAKGKTVAVWGTGLDVVYPKENKRLAEEIVTGGGAIVSEYPLGTFPAPQNFPIRNRILSGMSVGVLVIEAAEYSGTRITARCAMEQNRDVYAVPGNVTNKNAWGPNTLIKQGAKLTATWEDVWEDLPSQTRLELEDAMGAGRANESNVGQSASLFTGPNESGIGQTGQAMAEHERLVFARIRHDEAIQLDELMEQMEAELASAEIFTALFELELAGRVKALPGKNYVRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW2</accession>
    <name>E8WXW2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">nnrE</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="13" type="ordered locus">AciX9_2784</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581122.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2784"/>
    <dbReference type="EnsemblBacteria" id="ADW69807">
        <property type="protein sequence ID" value="ADW69807"/>
        <property type="gene ID" value="AciX9_2784"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2784"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_0"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="427"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="540" mass="56151" checksum="2A3713A78B069DE9" modified="2011-04-05" version="1">MKILTAAEMKQADDSSVAAGIPIADLMEAAGEAVAAFCLRQYPQAAHVMVLCGKGNNGGDGFVAARLLAGEGVGVRVLLAGRQDDVKGDAAEALALLKEATSDEIVEEFVDETDEHLEAIIELLSEADLILDAVVGTGFKPPLRGPAAILRDALAKSAIPVVAVDLPSGWDADSQQQTAEGAFRADAVVTFTAPKHAHIFGHLTAATFGPVVVADIGSPEDTIQSSQNLNWAGTAKSVTERPRDINSNKGKFGHILIIGGSFGTAGAPSMASLAALRAGAGLVTAAVPREIVNLVGSVTPELMVRPLLHDAEGTATAANLTNLETLTKGIKVIAIGPGLSTQGEASEFARGVVAQTKLPIVIDADALNAFDADHVHLLDGANRTMVLTPHPGEMARLLGKTVKEVEADRINLARKFATEHHLTLVLKGWRTLIAHPDGSIAVNTTGNPGLAKGGSGDILTGIVAALLGQYPDNVAEAVEAAVYLHGLAADLVARHLDEKSILATDVISHLTQAFRYRNVDADGLTWFCGIQPKPKEPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX5</accession>
    <name>E8WXX5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0442</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578842.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0442"/>
    <dbReference type="EnsemblBacteria" id="ADW67514">
        <property type="protein sequence ID" value="ADW67514"/>
        <property type="gene ID" value="AciX9_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0442"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085077_3_0_0"/>
    <dbReference type="OMA" id="EHQICLE"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00213">
        <property type="entry name" value="GmhB_yaeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="20914" checksum="C6176D400325AEA3" modified="2011-04-05" version="1">MPNKTKSKALFLDRDGVINEEIGYLHRPEDVVFLPGIFALTQTAQRLGYKLVIVTNQSGIARGLYTTTQFETLMTWMRTEFLRHEVTLDAVYHCPYHPTHGIGDFKREHEDRKPSPGMIHRAARDLNLDLSQSILIGDRCSDIAAATAAGLHQAFLIAGTEQTPCPHPHKKIASLSELETWLKLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY87</accession>
    <name>E8WY87_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9B dipeptidylpeptidase IV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1664</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580033.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1664"/>
    <dbReference type="ESTHER" id="acism-e8wy87">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68714">
        <property type="protein sequence ID" value="ADW68714"/>
        <property type="gene ID" value="AciX9_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1664"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_2_0_0"/>
    <dbReference type="OMA" id="DKMFYLV"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="2">
        <location>
            <begin position="124"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="572"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="783" mass="87368" checksum="2EBDD879BECB9D30" modified="2011-04-05" version="1">MMNSSRAHRGLRLQLLTCTSTAILSLVPIWAQSLPGNLPSPAFVQGFDKLYKTRGFRARTPAESRWLDGGERYTVLETPAPDAKSLELVAYETATGKRSVLVTEKQLTPEGATAPIQVEDYAWSADKQSLLFFTNSKKVWRQNTRGDYWVLNLQGSKLTKLGGTAAPSTLMFTQFSPDARSVGYVRENNIYVQDLATGTIRQLTTDGSADIINGTSDWVNEEELDIREAFRWSPDSRSIAYWQFDQSGVSDYTLINDTAANYPQLFHYKYPLVGTTNASVRAGVVSVDGGATHWMKLPGDYRNHYIPRLDWADNSQQVAVEYLNRQQNDDLIFLADAATGEAKPLFEDKDDAYLDVDMSAKIMSHFVWLPASHANTKEKPDLLWLSERDGWRHAYRVSRQTGKLELLTNFPADVIEPVSVDEQHGFFYFTASPSDPIRAYLYRSRLDGKGVPERVTPAADAGTNHYDISENGTYAIHMRQSSTVAPRFDLVRLPEHMVVRTLEENADLAAKVKDTMSAPKEFSETDIGGGVTLSTYMIKPLNFDPSKKYPVLVQIYGEPAGTTVDDTWDQFSALFLQLIARDGYIVLSFDNQGTPAPRGRAWRKAGYGAIGVLSTQQQADAIRSFAKTHPFVDTSRMAMWGWSGGGTNTLNMMFRNPGLYSTGISVAPVPDQTRYDTIYQERYMGLPTENAKGYHDGSAINFAQGLTGNLLLVHGSGDDNVHFQGSELLVNKLIQLGKNFDFMDYPNRTHAINEGQGTTVHVYRLIARYLEEHVPAGARPQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC3</accession>
    <name>E8WYC3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage major capsid protein, hk97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2806</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581144.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2806"/>
    <dbReference type="EnsemblBacteria" id="ADW69829">
        <property type="protein sequence ID" value="ADW69829"/>
        <property type="gene ID" value="AciX9_2806"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2806"/>
    <dbReference type="HOGENOM" id="CLU_2649374_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="76" mass="8394" checksum="EA601307878C7AF5" modified="2011-04-05" version="1">MSQSTSNLPTLINPLTNQPYPEFEFNSGPYFKSATGELRKPSIALTQRDLAAQRAMSAGTGEHAGHLIGTQFWRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC9</accession>
    <name>E8WYC9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581150.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2812"/>
    <dbReference type="EnsemblBacteria" id="ADW69835">
        <property type="protein sequence ID" value="ADW69835"/>
        <property type="gene ID" value="AciX9_2812"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2812"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188610_0_0_0"/>
    <dbReference type="OMA" id="APDFGQN"/>
    <dbReference type="OrthoDB" id="1674922at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234163" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="233" mass="25436" checksum="44C41F10EE482F6A" modified="2011-04-05" version="1">MTIAIRRPGMIAALLFGAACAASFTSAAHAQDTEPPTFLDKQLARLDLGITGVGEFSKTTNGPNYLNQTVTLKPSNTLGYMGTVGYSKSPWVGGEFNFQNIRYTDNFTLANTATTPANQNSQNIAIQTNVIELSAGYLIRPAHTFYGIQPYASAGLGAMDFRPTPGGGQGLPHEGVRSFYYTVGGEELVTTHFGLRGGIRQTFYLQPDFFQNFLRNSNHSYTIQPYAGFFIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE1</accession>
    <name>E8WYE1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Folate-binding protein YgfZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2824</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581162.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2824"/>
    <dbReference type="EnsemblBacteria" id="ADW69847">
        <property type="protein sequence ID" value="ADW69847"/>
        <property type="gene ID" value="AciX9_2824"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2824"/>
    <dbReference type="eggNOG" id="COG0354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_6_3_0"/>
    <dbReference type="OMA" id="RHHELGP"/>
    <dbReference type="OrthoDB" id="1984573at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="8"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="34971" checksum="8623D36AB0784B54" modified="2011-04-05" version="1">MSLTALLQSASFAPITNLGWIKVTGSDRTRWLNGMVTNNITALTPGQGCYNFVLSNQGRIQADLTAFPTEDAILLETDLTRIPALTALFDRFIIMDDVELEDISPTRAGLTLIGPAALRPLLDLGLTPLALLPLETSQITWNGAEVTFIHAHSPLIPRFELWSDPKTIALLTAALEAANIPQAAEDDLEHLRLLEGTPLYGTDIRDKELPQETAQLRALHFSKGCYLGQEIVERINSRGAVHRTFAGFLLTGDLPPAGTPLTADEKPVGEITSAARIPLPTGDIQLALGYIRREALDRAATITYPGGTAIAVKLPTEAARTQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH1</accession>
    <name>E8WYH1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2854</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581192.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2854"/>
    <dbReference type="EnsemblBacteria" id="ADW69877">
        <property type="protein sequence ID" value="ADW69877"/>
        <property type="gene ID" value="AciX9_2854"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2854"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_1_0"/>
    <dbReference type="OMA" id="IELHITF"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="265"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="42565" checksum="22B3D39222698DB0" modified="2011-04-05" version="1">MLAWSISIGRVFGVHIRLHAFFLLLLFLCLTWSSYIEANILRGFALWLLLILAVVLREIARALAAAWFSLDLRGVLLLPTGGILSFAGAGPSPRIQRRMALVGPITNAVAGLLFAAIILTISPHLQLIEPRWVTPQHLLRTLVWLNILLAAVNLLPAWPLDAGRALRTRTPRPESSQNLDPSSPKPQPTRLARIRPSAFLPQNASTRLFASLGSSIAIFLLLMGAFNRNPWLIMAGVAIFIGAQIERQGVLLQTGLDQVLVKDVMLTDFSVLSASATLEDALEHARHSLQDVFPVVRGVTFVGAISRQTILDALDSGPNSYIQGLMSRTFQIAAPTEPLPAAISRISGQNAQLVPILEGDRIVGILTPQNLSRAMSILPRKPLTSARQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN6</accession>
    <name>E8WYN6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0563</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578962.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0563"/>
    <dbReference type="EnsemblBacteria" id="ADW67634">
        <property type="protein sequence ID" value="ADW67634"/>
        <property type="gene ID" value="AciX9_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0563"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="OMA" id="SMEFAPF"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="34528" checksum="84EEE22F54369DE5" modified="2011-04-05" version="1">MTKTVGKKSAPVKAAAKEAAPAGERLQKILAQAGLASRRKAEEIILDGRVQVNGTVVTELGTRADATKDHIRVDGKLIKGPEQQKYYMVNKPRGYVTTLDDPQHRPTVMQLMTPKSGPHETQVRLYPVGRLDYLSEGLLLMTNDGDLANALSKASTGVEKTYLVKTSGVPPDSALDQIRRGIMIDRGRLDEVRAGRRDRILTAPAKVELVRRGDNPWYEVTLTEGRNRQLRKMFEEVGHHVEKIRRIGYGALRLDVAPGEFRELKPGEVMALDRASKGKKVEPKRNLPEFSKLKAPVKPKRPGAGKSYAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW2</accession>
    <name>E8WYW2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1750</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580117.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1750"/>
    <dbReference type="EnsemblBacteria" id="ADW68798">
        <property type="protein sequence ID" value="ADW68798"/>
        <property type="gene ID" value="AciX9_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1750"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2180132_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="11984" checksum="13108E26BFDB5069" modified="2011-04-05" version="1">MTTSSQQSHAARSTTKTFEQVIDSTSTMLYDVARSLVTRPERVNVKVTSANDITLFVLQVSPEDAELINGVQGRTIASLQTLVSVISARNQRKFRLKMQVQEAVPSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX9</accession>
    <name>E8WYX9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2871</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581209.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2871"/>
    <dbReference type="EnsemblBacteria" id="ADW69894">
        <property type="protein sequence ID" value="ADW69894"/>
        <property type="gene ID" value="AciX9_2871"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2871"/>
    <dbReference type="eggNOG" id="COG2351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_1_0_0"/>
    <dbReference type="OMA" id="ENQNYHI"/>
    <dbReference type="OrthoDB" id="1955791at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="8">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="12143" checksum="7CCE167D0AB2DC18" modified="2011-04-05" version="1">MGISTHILDTAVGRPASGVAVGLSLLEGEEWRTLRTETTDADGRCKAMLAEGEALTVGVYRLRFATATYYEAQGLSGLYPFVEIAFEVRDAGQHFHIPLLLTANGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY8</accession>
    <name>E8WYY8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2880</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581218.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2880"/>
    <dbReference type="EnsemblBacteria" id="ADW69903">
        <property type="protein sequence ID" value="ADW69903"/>
        <property type="gene ID" value="AciX9_2880"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2880"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020726_2_0_0"/>
    <dbReference type="OMA" id="FTPMLFM"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="101"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="379"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="582" mass="64966" checksum="17BB533D675D1AC1" modified="2011-04-05" version="1">MHEFKLWAPTPQKVAVKIADKTYPMAGPSDKGIWKTTVEDAAPGTEYAFLLDDDTTPYPDPRSLSQPHGVHGPSVIYDQKAFNWDDHTWQGPPLTGAILYELHIGTFTGSGCFDSAIERLGYLQDLGITHVEIMPVAEWAGDRGWGYDGVDLYATTEHYGGPEAFKRFVNACHGHGIAVILDVVYNHFGPVGNYTGKFGPYITDRHRTPWGDAMNMEQEGSDQVRRFFIDNAIMWMRDFHVDGLRLDAIHEIIDRSAIHFLEQLSAEVDNLSAAVGRRLVLIAESDLNDPKIVKPIEAGGYGMDAQWSDDFHHSLATLLFTEPGHKGYYDDFGAFECLAKSLKSVFVFDGQYSTYRGRSHGRPVDALSAHHFVGFIQNHDQIGNRALGDRIDQTIGLAKTKVALGIVLTAPFIPLLFMGEEFAASTPFLYFADHDDEEMARLVSAGRKKEFAAFGFDQAEIPNPEDPATFTNSKLNWSEIGSGRHAEMHQWVRSLIHLRRESVCLNDGDRGHLNVTFNEDKRWLRMDRRLVTVLCNLGPDPAQFNVTSDHRLILSSEPTTVLSNCCVVVQPNTLAILSAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ5</accession>
    <name>E8WYZ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2887</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581225.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2887"/>
    <dbReference type="EnsemblBacteria" id="ADW69910">
        <property type="protein sequence ID" value="ADW69910"/>
        <property type="gene ID" value="AciX9_2887"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2887"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_20_2_0"/>
    <dbReference type="OMA" id="DVPEWDS"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9548" checksum="8AE5858176B6E72A" modified="2011-04-05" version="1">MQQQEIYTQLTSIFHDLFDDDSLVLTPELTAAEVPEWDSFNHINLIVAVESRFKIKFQTAELESMNSVGHLVNIISQKVAAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ60</accession>
    <name>E8WZ60_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0591</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67662">
        <property type="protein sequence ID" value="ADW67662"/>
        <property type="gene ID" value="AciX9_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0591"/>
    <dbReference type="HOGENOM" id="CLU_707441_0_0_0"/>
    <dbReference type="OrthoDB" id="1558131at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030807">
        <property type="entry name" value="Methyltran_NanM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04371">
        <property type="entry name" value="methyltran_NanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="390" mass="43475" checksum="6E32AA8F698CF7B4" modified="2011-04-05" version="1">MLKPRHLFHPVRTLRTARSLVSSNLLVRRSARAGKRRFAHDERYILQSVTDGFLPHTSEGTEDEALLQRICTAYKKAVAQEGCASDIYQATGWWQQVRTRSLGPVMKALLASDTKALHALYRNFFRDSCSAGLISIPPGMAKAYFQGGMRDLHRHYYLQDVLQSIDYWRLQTEGRFAIKELAGPAIGNPFGAFIEGTLVESGAEYRHGCAQSIKDRLIDPASAVAEIGGGFGGMAYYLLRNQHGMRYINFDVPESLALAAYYLGTAFPALKLLLFGEVEVTQRNIEQADVILMPLSQLEVLPQNSVALTFSAHAMSDLGNGAMAVYLQQVERISQDAFLYIGHEKGHQRLSATMAARAVPLQLVKSSGSDWNRHRSPETREVETLYKPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ78</accession>
    <name>E8WZ78_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0609</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579008.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0609"/>
    <dbReference type="EnsemblBacteria" id="ADW67680">
        <property type="protein sequence ID" value="ADW67680"/>
        <property type="gene ID" value="AciX9_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0609"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="30429" checksum="AB88A15123DA2FC1" modified="2011-04-05" version="1">MRSSATSLVKDSGCTDGPVQPFPFTMAFQPIVDVEAGKIYAYEALVRGVNNESALSVLSQVTDENRYAFDQGCRTTAIRLAQRLGLAETGAKLSINFMPGAVYNPTACIHLTVATAASVGFPLERLVFEITETEEVRDRQHMLSIFKEYRKHGFEIAMDDFGAGFCGLNLFAELTPDILKIDMELTRRIHLRPVAMATMRCLVQLCAELKIPLVAEGVETMEEYRALKECGIRLMQGYLLARPGFETLPAFVVPKEDRVSTGRIGPGFKGQVHTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC8</accession>
    <name>E8WZC8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module component, TIGR02574 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1768</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1768"/>
    <dbReference type="EnsemblBacteria" id="ADW68816">
        <property type="protein sequence ID" value="ADW68816"/>
        <property type="gene ID" value="AciX9_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1768"/>
    <dbReference type="HOGENOM" id="CLU_185169_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02574">
        <property type="entry name" value="stabl_TIGR02574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7888" checksum="B89388F3EDF21E46" modified="2011-04-05" version="1">MSTLPSQISDLSIAEKVELLGALWEDIEAHAPALSDEQEAELDRRVAEYERNPSDVIPWEQLRAELFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS0</accession>
    <name>E8WZS0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase</fullName>
            <ecNumber evidence="5">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0660</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579059.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0660"/>
    <dbReference type="EnsemblBacteria" id="ADW67731">
        <property type="protein sequence ID" value="ADW67731"/>
        <property type="gene ID" value="AciX9_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0660"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_0"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="8">
        <location>
            <begin position="386"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="668" mass="72201" checksum="A8600CB90CCE4272" modified="2011-04-05" version="1">MALFGAVAGLAEEMAGTASRLKKRAAIAAAILAVHEELAEEVGLFCLYLAGLPFAEADPRKLNAGGALLSKALLAVSGATGEQLTAGYRKYGDMGAAGFDLLQLHPTSQTRDMGHPLLLGDVRDAFAGMATAKTTAIRAGLVEGLLRRATALEAKYLLKLMLGDMRIGVKQSLVEEAIGVAAAAEVADVRHAVMLEADLGGAAMRAFGGTLAEARMRLFHPLGFMLASPVETPEEAIERFTAKPVKVAKAKKSKKTEESDELLVAEIEGAMLEDDKRTTEGTEGKERSTEATVGVQAFLEDKYDGMRAQLHFGDAEQVGRVAIYSRNREDITESFPELCEAFSEASGELGGLILDGEILGWDFQHGVALPFALLGQRIGRKKVGNEIRQQVPVVFMAFDLMFERGKLTLGLPLRERRRRLEEVVGALAEKAVSPLVLTEHAARRHEAQARMFGGDEEAEAGVARLMLSPSKLVESAEEIDRAYADARARANEGVMIKAADSVYLPGRRGLAWVKLKRELATLDVVVTGAEFGQGRKAGTLSDYTFAVQTDAGELLNVGKAYSGVTDAEILELTEFFKAHTLEDHGHSRTVEPLVIFEVAFNNVMRSDRHASGFALRFPRILRIRTDKPLGEIDTVARVEEIYQSQVDKPKDSAKAVKGSGQAVMGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZT4</accession>
    <name>E8WZT4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ordered locus">AciX9_0675</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579073.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0675"/>
    <dbReference type="EnsemblBacteria" id="ADW67745">
        <property type="protein sequence ID" value="ADW67745"/>
        <property type="gene ID" value="AciX9_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0675"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_6_4_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009991396" description="Probable endolytic peptidoglycan transglycosylase RlpA" evidence="3">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="19602" checksum="3CA5F4DFF820B21C" modified="2011-04-05" version="1" precursor="true">MLQYLKMDLIAACMAVTTLFSLPTPVPATAPIATVAPMVNPPALVPVAGNSVAKKLPVAARIHASVAPVLTKALHPLRLAGTGMASWYGSMWNGKKTASGETFNETLLTACHRTLPFGTRVKVTAVNTGKSVIVKINDRGTMTPSRIIDLSSGAAKQLGIINAGVAKVKLEVLDKVENPATTHQMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV9</accession>
    <name>E8WZV9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chalcone and stilbene synthase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0700</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579098.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0700"/>
    <dbReference type="EnsemblBacteria" id="ADW67770">
        <property type="protein sequence ID" value="ADW67770"/>
        <property type="gene ID" value="AciX9_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0700"/>
    <dbReference type="eggNOG" id="COG3424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_0_1_0"/>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="216"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37812" checksum="B02D8FF28C1E47C0" modified="2011-04-05" version="1">MQIASVGTSFPPHRYTQAEIAEALVERWRDKLPEPRLLTRFHLNCGVEHRYTVLPLEAYPSLVGFGATNGAWITAAVDLGEQAITRALAPIGLTAADVSAIFFASVTGIASPTIDARLINRMPFPTHVKRTPIFGLGCVAGAAGIARASDYVRAFPDQIALLLSVELCSLTWQDDDQSVANLISTGLFGDGCAAVVIAGDNVKLPGPTAGPKILATRSTFYRHTEHVMGWDIRDTGFRIVLSPDVPKVVLENLKGDVDTFLTSQSLTQSDITSWIFHSGGPKVLEAAEKALTLPPEALALSWKSLREVGNLSAASVLCVLEDTLTNHPGAPGTYSILAAMGPAFCLELILLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY8</accession>
    <name>E8WZY8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1837</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1837"/>
    <dbReference type="EnsemblBacteria" id="ADW68884">
        <property type="protein sequence ID" value="ADW68884"/>
        <property type="gene ID" value="AciX9_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1837"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016354_0_0_0"/>
    <dbReference type="OMA" id="WERGPYW"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="721" mass="80466" checksum="5313A1F6E177F93A" modified="2011-04-05" version="1">MNSDQQSSLNATFRCCFWAAVALCSFVIRPHLVAQTPSPSTTQGASLRVVRNRAPLTPNQFDPLPLGAIEPRGWLRDQLEIQAKGLTGHLDEFWADVSQKSAWLGGDGEAWERGPYFVDGLLPLAYELKDQKLIEKANAWVEWTLTHQRPDGEIGPTSNSDWWPRMVMLKVLTQYEEATGDPRVEPLMTRYFTYELAELPKRPLTSWGRYRWQDNVLTVLWLYNRTGDPRLMELARLLREQGFDWKESFKSFPFKGKQTAQSLGLDRTHDNTDRAMQAHGVNNAMALKASPLSYVLTGHAGDRAAVYQQIGELERYHLLPNGMYSGDEHLAGDNPSQGVELCTVVESMFSWELNLAVLGDARFADRLERIAFNALPGTISDDMWSHQYDQQPNQVACTRGQRQWSSNGPDSNLFGLEPHFGCCTANMHQGWPKFAESLWMGTADGGLVATAYAPNRVTIELPGKESGAHQPKTFTLDEETNYPFDGMLRFTVHTGRPASLPIVLRIPGWAAAAKLTINDGATETIRPGCPQAAYDGRLHGSGANGTPDGCLFHTIRRTWKEGDRFELLLPLEPKVTRWYRGSVAVERGPLLFSLKMEQDWKKLDQHAELSADWQITSETPWNYALAVDANNPGRTISVKTDLLGPVPFSSQQVPVQLTVYGRLDPAWTLFEGSAGPLPESPVSSSAPLVPLVLVPYAAAKLRITAFPLLDMPENRAEVQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ3</accession>
    <name>E8WZZ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1842</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580208.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68889">
        <property type="protein sequence ID" value="ADW68889"/>
        <property type="gene ID" value="AciX9_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1842"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480428_0_0_0"/>
    <dbReference type="OMA" id="DDRGHYE"/>
    <dbReference type="OrthoDB" id="1395526at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234214" evidence="2">
        <location>
            <begin position="23"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="596" mass="62340" checksum="4AF093676C504370" modified="2011-04-05" version="1">MKLSPWRLTALLLMLALPCCRAAFGSDASGAPVFRISGIVLNSRDGSPVARCRVSADQVGSAARADRPSQQSAPGVARRGPGQQRSFGLGRGQNNVAPQGAQDAVVTDARGNFSLTVSHAGMWRVTAAARGFHSQAYEEHEGYSTAIALTAAVPDMALSFRINPDAVITGIVFDEAGEPVRQAQVSVETLGVKEAGRAPANQAAGFAQTDDRGHYEISSLTACDYHLSVQAHPWYAAGTSGRAVASDPSLDVVYPATWFPAALDAASAETIHLRPGEERQADVHLTPLPSVHLKIPRNDANLPAGSEPRGIRPPMISSISNSGAFIGMPQVTTSATEWDMGGLAPGTYQVRVPGALGETPSLVQLKIGPGSSTVIGLEGASAPSKVSISIDGVPDRTVERVILTDVDSGQTYVSNIHRKGRGPNIQSDSDSVDDDVEEGVRSILVPPHQYEVSLVGSDGVFLTGIQATGAQVNGRTVEVMGAASSLIIHAATGRAEVTGVVSQSGKPASSVVVLLVPSTFGQPNNLTDVGRDQTNTDGSFILQNVIPGQYILVAIDHGWEVNWHDPTTLARYLSAGTPVLVKASAHLHQDIEASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X039</accession>
    <name>E8X039_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1889</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580254.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1889"/>
    <dbReference type="EnsemblBacteria" id="ADW68935">
        <property type="protein sequence ID" value="ADW68935"/>
        <property type="gene ID" value="AciX9_1889"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1889"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_1_0"/>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="96"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18477" checksum="7D3B5D49DAD9208D" modified="2011-04-05" version="1">MQGNELKDFLKELIEFLKSQEVAEFDLEQADLKVRLKFAGEPVPAAPAFDMAQLARMMSANQAPVMAAPAHVAPSHAVGEAPAAAAAAPVIEDAKHHVVKSPIVGTFYDAPSPGSPSFVKVGDVVEVGQVLCIVEAMKLMNEIESDMAGEIVERIAKAGQPVEYGQPLFAIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X076</accession>
    <name>E8X076_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581371.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3037"/>
    <dbReference type="EnsemblBacteria" id="ADW70057">
        <property type="protein sequence ID" value="ADW70057"/>
        <property type="gene ID" value="AciX9_3037"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3037"/>
    <dbReference type="HOGENOM" id="CLU_154570_0_0_0"/>
    <dbReference type="OMA" id="MQITLEI"/>
    <dbReference type="OrthoDB" id="1986825at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10635" checksum="86CDA7AADE9D0742" modified="2011-04-05" version="1">MQITLEIPDDFAAQISENGHDLPRRLLEDAAVGAYCRDTLSRHELQSRLGFATQYELDMFLKERGIEHGSYSGQDLLDDIATLNLARLKQKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X087</accession>
    <name>E8X087_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3048</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581382.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3048"/>
    <dbReference type="EnsemblBacteria" id="ADW70068">
        <property type="protein sequence ID" value="ADW70068"/>
        <property type="gene ID" value="AciX9_3048"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3048"/>
    <dbReference type="eggNOG" id="ENOG5033QEF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794019_0_0_0"/>
    <dbReference type="OMA" id="LWISPGW"/>
    <dbReference type="OrthoDB" id="1280949at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233548" evidence="1">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="39955" checksum="30B2ECD53BB292B3" modified="2011-04-05" version="1">MSRTSPLFAAAFLTATLTVSAFSQQLTPAPAVSSAPAPSRLMTLDVVVAPKSGVPVAGLPQSAFTLLDNGRSEEIKSFREVKGGATNLQVILVIDSVNARFSTVSYERQEIGKYLLADGGRLAHPTALAIMTDTGIQMQQGYSTDGKSLNESLEQSVIGLREIRRNSGFYGAEERLDDSLRSLNLLIQHEKTVPGRKLVLWISPGWPLLSGPAVDLSSKQRTALFRSVVQTSTELRQAGVTLYNLNPVGVGEDVGRAFYYQEFLKGVTAPNHVDLGDLGLQVIATQSGGLVDMLNSDVAAMIRRDVRDADVYYELSFTPAPGEDKIEYHGLQVKVPDTSLTARTRQGYYALPPGVGTDQPIVPPPLPTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E9</accession>
    <name>E8X0E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0743</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579139.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0743"/>
    <dbReference type="EnsemblBacteria" id="ADW67813">
        <property type="protein sequence ID" value="ADW67813"/>
        <property type="gene ID" value="AciX9_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0743"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_0"/>
    <dbReference type="OMA" id="VKHENHT"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="33857" checksum="5E5199CDC5425EE6" modified="2011-04-05" version="1">MSWSLPTLGELESAAELIYRHMPATPQYRWPLLDAVAGTEVWVKHENHTPVGAFKIRGGIVYMDMLLRTRPDIRGVVGATRGNHGQSMGFAARMTGTSATVVVPRGNSPEKNAAMRALGVAVIEAGEDFQEACEYADALAQDRGLHRLPSLATELVCGVGTYALEFLRTAPVLDTVYVPIGMGSGICGMMAARDALNLPTKIVGVVSTGAPAYKLSFEAGRKIEHDVTTLLADGLACRSPNEDCLAAMLAGVDRVIAVDEDEVAAAMRSLFIATHNVAEGAGAASFAALMQEKDAMQGKRIGVVLCGGNVDADIFAKVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F3</accession>
    <name>E8X0F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0747</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579143.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0747"/>
    <dbReference type="EnsemblBacteria" id="ADW67817">
        <property type="protein sequence ID" value="ADW67817"/>
        <property type="gene ID" value="AciX9_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0747"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_0"/>
    <dbReference type="OMA" id="VIVCWFN"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="48749" checksum="CE1371069B205686" modified="2011-04-05" version="1">MSASVQQANPGSDQQVDARALYSKISWRLIPYIFILYILAYLDRVNVGFAAVEMRRDLNLSATVYGLGGGIFFLGQLMFDLPSNLLLGKVGPRLWIARIMITWGIVATCMMFVKGAHSFYLLRFLLGVSEAGFFPGMILYLTYWFPSGERARAIAKFMTATSIAGVVGGPISSFLLSLEGKAGLHGWQWLFLMEGLPTFLMGISVLFVLNDHPDDAGWLSDPEKKWLDTELERDRKEGGASEKHNLLDAFKLPMVWVLAGIFMLDQIGVYTVNLWMPLLLNSFLHVGKLGDAAGASVIARYATVPYIAAAIFTVIAGWSSDKTGERRWHIAGCFLLSVIGFTWAAYAHSLAAALCAMTLAAVGYWSMMGPFWALPTRVLGGQAAAGGVAIITMIGSIGGFVGPTLTGKLKDLTGNFTAGLLVISGLSLVGACLCIALKPADRKGTLTHPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H5</accession>
    <name>E8X0H5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0770"/>
    <dbReference type="EnsemblBacteria" id="ADW67839">
        <property type="protein sequence ID" value="ADW67839"/>
        <property type="gene ID" value="AciX9_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0770"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_2_5_0"/>
    <dbReference type="OMA" id="ALYWNPP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="39341" checksum="50A059DD32911963" modified="2011-04-05" version="1">MFFHFTPPHPAFLTPLLDNAYVFVGFFFLISGFVLAYNYADRPTLSKRSFWVARLSRVYPVYLLVLALSIPFVVIAERPAHTYFDWILGIVLTPFALQSWSPILATYWNTVAWTVPAEIALYFLFPYLLKLLKSVNHRIATPGRLIALIGVIWIVGLIPHTTYLLLNPDHLTAPATRYTYAYWLRALKYSPPAYICTFTAGVLLARLHGILTLKPAHRTLLAAIALGGLALFFATAVDQIPYVLIHGCLLLPLFAMLLLGLAGPGVITSAFSWKPLVKIGETTFSLYLIHFNAFLLIHYYHLPERLHIARFDPWISYIVIIAVAFGILRFYEGPARKFVLKTFTPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H7</accession>
    <name>E8X0H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0772</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0772"/>
    <dbReference type="EnsemblBacteria" id="ADW67841">
        <property type="protein sequence ID" value="ADW67841"/>
        <property type="gene ID" value="AciX9_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0772"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650147_0_0_0"/>
    <dbReference type="OMA" id="PRGKFLY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234042" evidence="1">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="430" mass="43754" checksum="EA9559912EC5B6EC" modified="2011-04-05" version="1">MKWNSTGRVAKALMVSMALGLGMTACSRDFTVAYLYATSATRTTSGVINAYSIDYQSGALQQLADSPIPSGGSNPVTLVASPNGKYIYVLNHDTSTVVAFAVGTDGKLFPQATTNVVQGNGLIGSFPTAAAIDGTGSYLYVTFTYQNGYTSARPGPGGIAVFPITASTGALGAPVTNTTVGTTAANPLPYFPTGMSPVGVTASLLHNFVYVVEQDTTTSNGVTSNVGNILAFSNGPASGTENGTLIPIAGTATVNATTLTGFKVGTTPSAIAEDPSAHFVYVTDQATNQLYAFNVITNGALQSNSSSPFSTGQFPLGLTIDPRGLFLYVANFGDSTVSAYAINQGNGALSGVAGTTQVSTGPTCVTVEPALGIYLYTSNNTDPTVSAEQLNPHTGSLTSVQGTPYTAQTLPTCAVSVANGSHATEVVNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I3</accession>
    <name>E8X0I3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0778</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579173.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0778"/>
    <dbReference type="EnsemblBacteria" id="ADW67847">
        <property type="protein sequence ID" value="ADW67847"/>
        <property type="gene ID" value="AciX9_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0778"/>
    <dbReference type="eggNOG" id="ENOG5032YN3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186880_0_0_0"/>
    <dbReference type="OMA" id="QWAAPFL"/>
    <dbReference type="OrthoDB" id="1885212at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="9587" checksum="AB4189340DD27B40" modified="2011-04-05" version="1">MTDYRVAPGDSQEDQVTAAIEQVTSKVPSSIFLGAAIASILGSVAFKAAKKEHEALFIGQWVAPFLILGLYNKMVKQHGSDAASSQKASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M4</accession>
    <name>E8X0M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1929</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580294.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1929"/>
    <dbReference type="EnsemblBacteria" id="ADW68975">
        <property type="protein sequence ID" value="ADW68975"/>
        <property type="gene ID" value="AciX9_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1929"/>
    <dbReference type="eggNOG" id="COG3447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022985_1_0_0"/>
    <dbReference type="OMA" id="HRDQDWV"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="297"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="469"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="620" mass="69568" checksum="1427A2F50912C4FC" modified="2011-04-05" version="1">MRSTIRRALLQFGATALTTAVLFHYLPANHLFYVWPLTGVQLAILWSVWNHRLSRVTQICAATAGFLAILIFQGYPLRVVAGLTCIQGLELWGMAAVLRLRISRFDDLKQMRHVARFGIVAVVVPMIAATLRAAVFYNTVHRTFLQTWFITGMAHSVGLMVTLPGLLFLISEESRRSQKFRSSYRLGLPAMLLTFAVTFGVFAQSKYPWLFLVFPPIVLALLVWGLEGAAIICPVITLMACYATAHHHGPVWVVVQGSMEIRTVVLQVFLWMVPGTALPVGALLDERQKAESEARAGQMIYQTLLDNAEDMILLSGLDGGQRYVSPGVLSLTGWQPEEFLSLAQLETLHVEDRDLARNLIESLRSGKRQHHFRYRILCKDASYKWVEAFLRGYSSAEDGHVTGYVATVRDMGSLARLEEQWSQERADLTRQNMHLEELAGNDELTRLANRRTFNRMLTQEVARHARAKNSLSMLMVDVDFFKKYNDRYGHPEGDVCLRMVAESIQIASRASDFAARVGGEEFTVLLPDTDQAGAEQAAQRILSHIESLQIRHEGSPFGYVTVSIGAATWPPEFVADEAYLIQQADRALYESKKTGRNRLTSMTADLQEIADGAMSRRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P1</accession>
    <name>E8X0P1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1946</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580311.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1946"/>
    <dbReference type="EnsemblBacteria" id="ADW68992">
        <property type="protein sequence ID" value="ADW68992"/>
        <property type="gene ID" value="AciX9_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1946"/>
    <dbReference type="HOGENOM" id="CLU_2734375_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="8116" checksum="E3D4268AFCDA879F" modified="2011-04-05" version="1">MPEAKHPAPQIEFYRPSEVATMLQLATQTVVGYCRKGIIPSIHVPDADSLTRIPKQEFHAWLEGHRHQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q2</accession>
    <name>E8X0Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage terminase, small subunit, P27 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1957"/>
    <dbReference type="EnsemblBacteria" id="ADW69003">
        <property type="protein sequence ID" value="ADW69003"/>
        <property type="gene ID" value="AciX9_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1957"/>
    <dbReference type="eggNOG" id="COG3747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107958_2_1_0"/>
    <dbReference type="OMA" id="QSEAMNR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006448">
        <property type="entry name" value="Phage_term_ssu_P27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05119">
        <property type="entry name" value="Terminase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01558">
        <property type="entry name" value="sm_term_P27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="17639" checksum="BC2F4A8043AFE5CB" modified="2011-04-05" version="1">MPAGRKRLPSAVHEAHGNPGHRKHAPEMDFSAAGEIGKPPSWLDAGAKAEYKRIVAALSDLELLRSTDVGVVASYAIAYSRWMAAEKQVTREGTVIQVMGSQGQTKMVKHPALLVAASAQQQMLRAGSLLGLNPVDRAKISASPKQAANPFSAIFAMTEEDPAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y3</accession>
    <name>E8X0Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3156</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3156"/>
    <dbReference type="EnsemblBacteria" id="ADW70167">
        <property type="protein sequence ID" value="ADW70167"/>
        <property type="gene ID" value="AciX9_3156"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3156"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_100_0_0"/>
    <dbReference type="OMA" id="MYEPSIC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="294" mass="32353" checksum="3A1BA8FDB5D2D6A1" modified="2011-04-05" version="1">MQLNELRRLAARAENRRTETGIPRIAMVKGAVPEHRLATVYEPMINLIVAGNKTMTVGDRSFRYDPATYFVMSVDLPAVGAVEPSADGEPYLAVSLTLEPVRLAQLLGDLPKTATEGRCSSGFSVAPVTPELLDAWLRMLRLLDQPTEIAALAPAYEREILFRVLQGPLGWMLREIAAPESTVSRIGLAIQWIRENFALPLRVKPLADMAALSASAFHRHFKTVTALSPLQYQKRVRLLHARTMLIAGEGNVTSTAFAVGYESATQFSREYARLFGSSPSRDAIDIANKVRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X115</accession>
    <name>E8X115_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/H associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0813</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579206.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0813"/>
    <dbReference type="EnsemblBacteria" id="ADW67881">
        <property type="protein sequence ID" value="ADW67881"/>
        <property type="gene ID" value="AciX9_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0813"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_3_1_0"/>
    <dbReference type="OMA" id="WRWNATR"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1538" mass="168952" checksum="63F35BEB5C1F5C39" modified="2011-04-05" version="1">MVAEPELQTALQWAHPVVQEWFTAKFGTPTEPQIAGWPSILAGETTLISAPTGSGKTLAAFLVCIDQLLRKAIAGTLAPCTEVLYVSPLKALSNDVQKNLDAPLREIQHLALERGYLSTEIRTGVRTGDTLTKDRAAMLRNPPHILVTTPESLYILLTAGKSRENLRRVRTIIVDEIHAVADDKRGAHLTLSLERLEALVCGENTLTPGAFLTGLATPPQRIGLSATQNPISLIADFLTGIHPTRKPATIVQVGQRRHLDLAIEIPSDELSSVASTAMWTEIFDKLAALTDHHRSTLVFVNTRRLVEKISFELSQRLSPEDVAAHHGSLSRGLRLDAEQRLKNGQIKILIATGSLELGIDIGNVDLVCQINTTRAVAVAMQRVGRAGHWRGAIPKGRFFATTRDDLLEQAALIRKMHAGELDLLEIPPAPIDVLMQQIVAMCGAEPWPEETLYNIVRRAYPYRDLTRPHFEELLNLLHNGIESSRGRYGAYLLRDGVQGHLHPRRGARMIAIANGGAIPDVSNFAVILQPEGLQIATLDEHFAVDSSPGDVVLLGNSSWRIQKVEAVGRVLVEDAHGAPPSIPFWEGEAPQRTSVVSDGVGTLREEIAARTSKVAPADLLNLGAPRLDSETWDLQNPTPHQQIEETISWLQQETCVCRAGALQLITYIVSGRAALGAVPSKTTIIAERFFDDGGGMQLILHAPFGGRVNKAWGLALRKRFCRGFNFELQAAATDNGINISLAEQHSFPLSDVFKFLTEHTAKELLEQAAIASPIFKNRWRWAAGRSLQLLRMSKGKRIAPQIQRTRSDDLMANVFPQAAACFETIVGDIEIPDHPLVREVMQDVLQEAMDLEGLIEILRGIEQGTIRCLAVDSPIPSVFAHELINAMPYAYLDEAGAEERRARATTLRRGLPATAEDAGRLDQAAIDTVRRQLWPDLRDEHELHDLLLTLTILPLATLDTEPVQDWPIFYERLLRTNRVQTIDCAGKPCWVPTERLQSVATLFTSPTTTSTVLPPQAVILSEAQNLSISPEAPQPLPLTPESATLSLVQGWLQILGPTTANALATRLNLSPAQIFQSFLTMELQGLLLRGTFELPPTQIDHEIEWCERRILQRIHRLTLGTLRKQIEPVSPAVYMRWLLGWQHLAPQTQLSGEEGLLEVLSKLEGFEAPAVEWERTLLPARVANYDPRWLDSLCLSGAVGWGRVSPHPAWSTGDGGAPRRVIPTNAAPITFYIRESAEWLPAALAAQCVDESNLLKALSQDALTIRALLAQRGACFSNDLQRITGLTRQQTQHALWELATAGLASADGFDQLRGMMDPRRKAAAATPTTLARKSAARTTAGRWSLLCEEHGPSENPGAPRPDSGTWVPHTTFEARRAEAQAHSIANARRQSAAHDSAARMLLCRYGVLFRDLLERESNAPKWRDLLPILRRLEARGELRGGRFVTGFSGEQFALAEAVDSLRASRNQASDHEITVAGADPMNLIGIVIPGDRVPAVPGRSTKFRNGVSVQDPTKPSSPEPESTFTQPTPEPSTIGLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D4</accession>
    <name>E8X1D4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ordered locus">AciX9_2043</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580405.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2043"/>
    <dbReference type="EnsemblBacteria" id="ADW69088">
        <property type="protein sequence ID" value="ADW69088"/>
        <property type="gene ID" value="AciX9_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2043"/>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_2_2_0"/>
    <dbReference type="OMA" id="EIHHGVA"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="261"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="538" mass="58238" checksum="772916A96F68E184" modified="2011-04-05" version="1">MRARAIMVLGTASHVGKSLLVAALCRIFAQHGVRVAPFKSQNMSLNSAATPEGLEIGRAQALQAEAAGIPPSVHMNPILLKPSGNMTSQVIVHGRIHGQFTAADYHRRRVEELFPIVTESYEHLAAEYDLIILEGAGSPAEINLKAHDIVNMRMADLADAHCILVGDIDRGGVFASLLGTIELLEPHEQARIQGFVVNKFRGDVALLEPGLRMIEARIHKPSLGVIPHYPNLALDEEDSLGLQQIATTPWAQSADPARPLRIAVIALPSLSNFTDFDSLTSEPSVDLRLIRTVETLANTDLVILPGSKQTVADLAWLNETGLAAAIQAHAATSLVVGICGGMQMLGRTISDPGHIESDSDAPIEGLSLLPIETTMQPHKTTVLSRGALLPTTLFNHPCPPTELTGYEIHIGTTTYLPNSHPFVRLNDVVILSEAQNLSILPGSPSPQPEPTPDGAIDPTTRIFGTYLHGLFDEDPFRHLFLTNARAFHHLTPPAALNNWKHHRESALNAFAAHVESSLDMPQIFSWAGLDYQALDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q4</accession>
    <name>E8X1Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC domain protein dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0906</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579297.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0906"/>
    <dbReference type="EnsemblBacteria" id="ADW67973">
        <property type="protein sequence ID" value="ADW67973"/>
        <property type="gene ID" value="AciX9_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0906"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_1_0_0"/>
    <dbReference type="OMA" id="ISSGWMT"/>
    <dbReference type="OrthoDB" id="1563802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17192" checksum="D37E93B118C7D1FF" modified="2011-04-05" version="1">MPNSELYFEDFQVGQKFHSAGSAKVTAEEIKEFGARYDPQPFHLDEAAGENSFFKGLAASGWLTAAIVMRLRVESVKVFGGMIGAGVDEMRWTEPVRPGDTLRTEIEVVSVRQSTSRKNYGIVKTTTLAYNQRNEVVLRSTVNFLAPVRAAFVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R3</accession>
    <name>E8X1R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0915</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579306.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0915"/>
    <dbReference type="EnsemblBacteria" id="ADW67982">
        <property type="protein sequence ID" value="ADW67982"/>
        <property type="gene ID" value="AciX9_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0915"/>
    <dbReference type="eggNOG" id="ENOG502ZAWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882136_0_0_0"/>
    <dbReference type="OMA" id="IGHVGLP"/>
    <dbReference type="OrthoDB" id="1086817at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34169" checksum="1B71F81486707272" modified="2011-04-05" version="1">MRKQSRYTLLAVLAVLVALAVALYLRWKAPPEVARLLPESDAMVYVSLKPLRAATHFDRTSVARSASYQQFVDATGIVAERDLDSAAFALHRMSNPNGANGLVAFSEVFEGRFDHDRLAKYLASAAANKETYADRTIYAIPSEGRTLRVVMLGYDMIAASNMPTPEQIHSIVDRERAGASPFAGSSLLSARYSEVPAFSSIWGIGRIGLPFSEGGRIQVMGMQLPVPADATFVASLQGFKLKIDEITASDGDALQSAAALTQLLGLFQAMQPEARTPEDKAVKQFVDSVKIEQKKSRAEITALLPGDALMSAFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X6</accession>
    <name>E8X1X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2093</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580453.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2093"/>
    <dbReference type="EnsemblBacteria" id="ADW69137">
        <property type="protein sequence ID" value="ADW69137"/>
        <property type="gene ID" value="AciX9_2093"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2093"/>
    <dbReference type="eggNOG" id="ENOG5033DD6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148050_0_0_0"/>
    <dbReference type="OMA" id="LDKFFHY"/>
    <dbReference type="OrthoDB" id="1981837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="13835" checksum="A31E1F89DDCE2C5D" modified="2011-04-05" version="1">MKVASLVARYLLGIIFLVFGANGFLHFIPMQPMPPVATQFVTALAISHYMVLVFLLQLVGGILLLANRFVPLALTLLAPIIVNIVLTHLLMAPAGLPIAILVVILWVLVAARVWSAFTPLLQQRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X260</accession>
    <name>E8X260_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581615.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70303">
        <property type="protein sequence ID" value="ADW70303"/>
        <property type="gene ID" value="AciX9_3292"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3292"/>
    <dbReference type="HOGENOM" id="CLU_2382088_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233600" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10258" checksum="6C68BB3F59E1BE4E" modified="2011-04-05" version="1">MPLPRLAIFVLLLIGVFRSCFAQAAMRPCAPAAEQTDDPGPACFTAKEEIGELPGGSYFWHLYTFPDRATAEAAKGRTLHRRAVVWQGVAFYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H9</accession>
    <name>E8X2H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2159</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2159"/>
    <dbReference type="EnsemblBacteria" id="ADW69203">
        <property type="protein sequence ID" value="ADW69203"/>
        <property type="gene ID" value="AciX9_2159"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2159"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_1_0"/>
    <dbReference type="OMA" id="IFCPCHG"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="89"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26257" checksum="7BFA91677AAB825A" modified="2011-04-05" version="1">MNDSNELASQRTEITAPQDQPVPVTASQSTSAEKAAKHTRRVFLFQLSLGLNAVVGAVLAVPILGYVLGPMFKKNGSYNSWVPLTMLDAMPVGATRLVEYLNPQRTPTDGDTDKVACWARRLSPTSYEVFAINCAHLGCPVRWFEQSQLFLCPCHGGAYYANGDRASGPPERGLFKYDVRVSAGRVYINAGEMPTLATQACREKKNEPLIHIQTDSAEQAASEAYNHIPISIASEPDGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X327</accession>
    <name>E8X327_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2207</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580567.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2207"/>
    <dbReference type="EnsemblBacteria" id="ADW69251">
        <property type="protein sequence ID" value="ADW69251"/>
        <property type="gene ID" value="AciX9_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2207"/>
    <dbReference type="eggNOG" id="COG2945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086287_1_0_0"/>
    <dbReference type="OMA" id="MDWARPQ"/>
    <dbReference type="OrthoDB" id="1090356at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="25118" checksum="A76502BA3BF78803" modified="2011-04-05" version="1">MPFPSQVRTLEDLRGPVGRLEAILNTGSPDAPYAAVIGHPHPPSGGTMHNKVVYHAMKAFTHFALPVLRFNFRGTGLSEGAHDEGRGEVEDVRAAVDYLHRLTSKPILFAGFSFGSNVGLRACCGDPRVQGLVGLGLPIRAAERDYRYDFLPHCIAPKLFISGDHDQFCPPDILAELMKTAPLPCQTVIIPGAEHFFQGIPTDPKPKLDQMQQALRTWLEGTFQLQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X337</accession>
    <name>E8X337_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580577.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2218"/>
    <dbReference type="EnsemblBacteria" id="ADW69261">
        <property type="protein sequence ID" value="ADW69261"/>
        <property type="gene ID" value="AciX9_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2218"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018437_0_0_0"/>
    <dbReference type="OMA" id="LYNSMNG"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="338"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="673" mass="72105" checksum="535CDFA23469D8FC" modified="2011-04-05" version="1">MRCSVLMLVGVLVAGGGLYGQAAPRVVEHGVYGVHLIERSIGSEEYEISSTGLRRKLSVTTNTSERGMKHTTTTTLEYRADLAPSRFEQHTITPATATAAAVDHASVTEINGDQVTAHEAESTRSFAKPAVAFPGFANMPAAAQMMMMRYWLHHGRPQKLVLMRASADALPVEIRAVGHDVFNIKGAMVRLTRYTVENLVFGREVLWMNDRERLAGVMTFAAGLPQEEVLDEYKSAFDPLFGSAVRQEMLDLATLTRAVKPEASGSYAIVGARLIDATGAVPVENSVVIVRDGRIAAAGAASAVTVPAGMQVIHAEGQSVLPGLWEMHSHYSGVEFGPALLSAGITTARDCGGELLFLIAVRHAIAEEHQLGPRLLLAGLVDGDNHDAFGLFTAGTAEEGKSVVDMYADAHFDQIKVYTQIQPEVLRAISEEAHKRGMTVTGHVPAAVNAFEGVADGMDQINHLQFVTKAMVPEWSAAPFVLNDLKSDRAKRLIALLAAKQIVVDPTIGWGEMAGHPKSIPTWGLEPGVKAAPFPLAWRFNNIGVAGMDEAKFKDGMVAKLQVIGALFQAGVPIVAGSDTNLLGYGLDRELELYVQAGMTPMQAIQSATSVPARVMHHEGDSGTIAVGKRADLVLVMGNPAEKISDLRRVVSVVTEGRIYDSKAMGATVGFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X343</accession>
    <name>E8X343_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2225</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580583.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69267">
        <property type="protein sequence ID" value="ADW69267"/>
        <property type="gene ID" value="AciX9_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2225"/>
    <dbReference type="eggNOG" id="ENOG5032VPD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2287549_0_0_0"/>
    <dbReference type="OrthoDB" id="1957276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="101" mass="11413" checksum="63C20D4B045B607E" modified="2011-04-05" version="1">MSAQPFQIDYVSPLEDSDSANDNIDIHLRMDDGRVYSLLVATPNNIYSCMDNSQEDYFFGVPPIFVRVLDRKHIEEAINALLSEDDGRWLSIYGTLQVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B1</accession>
    <name>E8X3B1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3406"/>
    <dbReference type="EnsemblBacteria" id="ADW70412">
        <property type="protein sequence ID" value="ADW70412"/>
        <property type="gene ID" value="AciX9_3406"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3406"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_5_3_0"/>
    <dbReference type="OMA" id="TNNTRHY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14673" checksum="2A9CA1171C285CFF" modified="2011-04-05" version="1">MSRTSQLLFDSYSEHLLAGEPLYISCISHFELFVGLEKSLHQYSRQVQLTRLLLTLEVLPFEDQDALEAARIRAELERTKQPIGPYDTLIAGHAIARNLTLITANVREFARVPNLKWQDWTIPSQPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J0</accession>
    <name>E8X3J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1118</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1118"/>
    <dbReference type="EnsemblBacteria" id="ADW68181">
        <property type="protein sequence ID" value="ADW68181"/>
        <property type="gene ID" value="AciX9_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1118"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430707_0_0_0"/>
    <dbReference type="OMA" id="QNHLDSM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015391">
        <property type="entry name" value="SurA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09312">
        <property type="entry name" value="SurA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007913815" evidence="4">
        <location>
            <begin position="32"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="5">
        <location>
            <begin position="217"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="672" mass="71432" checksum="C71D22173A2DC1AF" modified="2011-04-05" version="1">MNEKRFDFGRRCGTLRIAVFAAAFAVSSLTAASAQIVKAPRYQGSGAVEAPVKQINLPPLPPAISPHGVVVENVVARVNDQIISRSDVDRSEEQLEQESAQQNLSPADLASRQKDMLRDMIDQQLLLSKAKELGLNADAEVIRRLDDIRKQNKLDSMDDLEKAARQQGVSFEDFKAQIRNQILTQQVVRDEVGRRLQTTQAEQAKYYEAHKKDFEQPEQVRLSEILVPLPDTASPAEIEQAETKANGLKSELMKGGDFAEVAKKNSGGPTAAQGGELGLFKRGALAKVIEDQTFALAPGESTQPIRTRQGFVILKVNEHQEPGAAPMKDVEPQIQEALYMNAMQPALRAYLTKLRENAYVDIQPGFIDSGASAKESKPVFTAYAPPVVKKKKVKNKARFDRHGAFSTASAAAPAAAASKPVVSSPDTTGGRTLTGAEAAPVDQKTGLAVIPASSKPGKKQKGAKREKVRFGQAPRTALAGNEQAETTPAATTPATPGSGAGGSVAPGAVMASDSNSLSTSGQPADTDANPLEAKAGPKTKTRFAARAVEHKEKKVAKVSAREKEKVAAQAAPMTDEEKAAAQTQATPLGLSGDTGPKKKVKKVKVKKVKGAPKEPRQPKKRLEEKKPEAPPPPPDIAPTANPALAPTAAAGEGKAKPTQPTPPPTTPPNPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N2</accession>
    <name>E8X3N2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1160</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579546.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1160"/>
    <dbReference type="EnsemblBacteria" id="ADW68223">
        <property type="protein sequence ID" value="ADW68223"/>
        <property type="gene ID" value="AciX9_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1160"/>
    <dbReference type="eggNOG" id="COG4774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_0"/>
    <dbReference type="OMA" id="YYERSYN"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234331" evidence="6">
        <location>
            <begin position="27"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="358"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="794" mass="85729" checksum="DAFA4E8FE7A1083E" modified="2011-04-05" version="1">MRSSTRFKRLVPIAFLALRAPLAAVAQTAEIRGSVLDPSGAALAGAHITLTGHGPEKTVSSDASGSYDFPSLPAGTYTLTIESPNFSRYENSSLHVSATGILDWPVHLTLQSASFSVAVQSDTDALQQIPTVGKTGTMLEDMPQSISVITSRLSESQGDLVLADTVRNAPGVIQGGTDGFGFADRFQIRGLEARIYNDGFSDGDERNGIPHSLNGVERVEILEGPGSSLFGSGPPGGTINLVHYTPSPRFGTGLQFQTGSFGLYSGSAYLTGSTPIHGLDYRIDTLLQHKDGYRALPGGDYELRPTLGYTTSRNVLLLAADGRELQAVPDPAGLIYLNHTPISVVPRDTKYSTPFSFGNQAIGRFTASDVWQAAPFLTVNNRFSYMYRNLSILRNGDGGGVVGTALTGRQLRNQHDVVNDFDYEAEPIFTFHTGRIRHTLLTGVEIQHQSIADNRATASLQNIANIFAPVIPETSRASLVFLRDATHSGFLDDLRATYEGLYATDQIDLTSRWKLRVGGREDFWQTTLAPQIFVPGRSLGNGVLIEPPSTFSRNDTPFSWNVGTVYRVLPGVNAFFGVAHSNLVNFNSEATQNGVQAPETGTQYEAGIKAAALNDRILITAAAFHVKRDNVFSLVSDIPVFNDQLTQGGEGSVELSLTHHWKLNANGTGMHAALTNNPSSPAATGRRPQGVPNRIVNLWTTYDIPFSHQQTLSFSGGFTNRSSMFADLLNTNSIPSYTTADLVANFKTHKLTGAFGVRNLADTRYFTAANGAGGFVGDARSYFGKLNWQFGNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q6</accession>
    <name>E8X3Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580650.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2296"/>
    <dbReference type="EnsemblBacteria" id="ADW69334">
        <property type="protein sequence ID" value="ADW69334"/>
        <property type="gene ID" value="AciX9_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2296"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="DKWQATP"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234334" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1175" mass="124812" checksum="E5B957FF828F1CF3" modified="2011-04-05" version="1">MRLCVRRFGIALLFLILVSCGHLQAQAVSGTILGTVTDPSGANVANATVTIVLTGQSTVHTAVTNESGNFTEPNLPAGTYTVTIVAPGFKKEARENITVLTNETARVDVGLTTGSTSETVTVTTAPPLLQTDRADISTTIEQKQIADLPLSSGNSFQSLLNTVPGMAPVVFNNSQFFNANNDLSVNANGQSSYVNLYQIEGIDDDQRTGIHIILVPPAAAIGNVDITTNNFEAEFGRAVGTVVNITLKSGTNQFHGSVFQNMENNGVNARNYFATGPNGRLVYNYTGGSIGGPVLKDKLFFFGDFLRVSDHESSTVNTNIPYYNVQGGNLNLSSYAGQVYDPNTGATATCTNPSAAGAPCGTGRTAFAGNVIPLNNPGISPIAVKVLSDIDALARNPKTNLASAAYIAGQLSNNFSQNSPFSKDFISYDIKSDYTITTKDHLSGRFSHQKTDTFQAPLFGAFYGGPTGGGFEATGVASAYSTGFNYDHIFSPTLFTEVRVGVAHLRNSATQTDYGSNDARTLGIPGNGPNGTNNTPTTSGQVAFQLSNFTGNGENGTGNPLIGYSQSLPWLRAESNIDFANIWTKILGNHTLKAGADIRRIRDDLLQGNINAAAGTFAFSENQTSAPGAPTVGQANAIASLLFDVPYSVGQDTNSTFPAYRQNWLFFFVSDKWQATPKLTVDLGMRYELYPPAVPRRAGGFVNYNPSNNQLVTAGVGGNPSNLGMQSNYTNFAPRLGVSYRATDTTVIRAGYGISYVPFVDNTYAYNYPIKTSTNYTFSPTFGPALNPAGGVVNFVTGIPSTPTIAFGSNGTLTESAANGTIGLANLYIPLNFKNAYVSSWNAVVQQALPLDMSLQIAYVANHGTRIDVAQNINQPLVYGQSAAYDPLNHAADGVTQTFLKTASVTQYFLGYSTNYQSLQVQLKRRFSKGLTFSSAVTWGKAQGYGTGAQDGGLLFWSGPVRRNYNLADFDRTLNYEQTITYELPAGKGHRYFSSGVSSYALGGWKLSAVVSALSGLPFTITTASATGGTTQTVNQIAPYQVTHGVSSTGNTRWFNPASFTTPATCTPYTPANPVACAVGNTQRNQFRGPGYFSDNLSLFKSFPIFREAALEARFDAFNMTNTPAFGLPNTAYANTITNPNSSFGRITSTLGSGTGNVNGVGGPRVLQAGVKIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z0</accession>
    <name>E8X3Z0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581809.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3493"/>
    <dbReference type="EnsemblBacteria" id="ADW70498">
        <property type="protein sequence ID" value="ADW70498"/>
        <property type="gene ID" value="AciX9_3493"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3493"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_4_0"/>
    <dbReference type="OMA" id="VPTWTYL"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="21164" checksum="5F73E05C4D0DE558" modified="2011-04-05" version="1">MLPELTTERLILRPLQLEDAARTQLLFPHWEIVQHLNAVVPWPYPPDGAFTFYRDSALPAIARNEEWHWTLRLKSDPALHIGSICLTRAAEENRGFWLGQPWQGQGLMTEAAEAVTEYWFEVLGMPTLRTKKAAANLASRKISERLGMRFVGLQEHDFVAGRLPAETWEITREEWKQQRAAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X405</accession>
    <name>E8X405_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ordered locus">AciX9_3508</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3508"/>
    <dbReference type="EnsemblBacteria" id="ADW70513">
        <property type="protein sequence ID" value="ADW70513"/>
        <property type="gene ID" value="AciX9_3508"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3508"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_0"/>
    <dbReference type="OMA" id="PIQPDFC"/>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21563" checksum="44F8B373F656849B" modified="2011-04-05" version="1">MAEEMAETKKDGPKLRLKGRLMSASEIERTLVRLAHEIVEKNDGATNLGLIGIKRRGVPLAQRLGKLIEKIEKTPVDTGVLDISFYRDDLSTAGPRPVVTKGAIGFDVTGRDIILMDDVLYTGRTIRAALDALFDHGRPKSVQLLVLIDRGHRELPIQSTFTGRTIPTSSREIIEVKLREIDEDEQVLLVELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X429</accession>
    <name>E8X429_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3532</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581848.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3532"/>
    <dbReference type="EnsemblBacteria" id="ADW70537">
        <property type="protein sequence ID" value="ADW70537"/>
        <property type="gene ID" value="AciX9_3532"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3532"/>
    <dbReference type="HOGENOM" id="CLU_2617045_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8743" checksum="06DBB307D24BA0A0" modified="2011-04-05" version="1">MAIAVHIELTPEEESLLREAAQHEGKSVDDLVRGATLWLAQQEAADRASLQRSIDQADRGEFVPEEEMDARIARMLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X475</accession>
    <name>E8X475_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0044</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578464.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0044"/>
    <dbReference type="EnsemblBacteria" id="ADW67135">
        <property type="protein sequence ID" value="ADW67135"/>
        <property type="gene ID" value="AciX9_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0044"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_7_0_0"/>
    <dbReference type="OMA" id="FTDQINP"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234354" evidence="1">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="33994" checksum="1A64919BC833B790" modified="2011-04-05" version="1">MLKKIAGVMLMGVVSALAQTNAVRNTPRTILVHAHRGGRALRPENTIPSFQHGIDVGADVLELDLAVTKDGVLVVSHSPYLTYPVDTDVAKERVCDGPALPPGTAIHTLTLAQLKQYDCGLHPLKRFPKQMAVPHTTIPTFDEVLELAPQGTFQFNVETKIYPNHPELTPAPEAFVKMIDDAVKRRHLQARVILQSFDFRTLHAMRAIDPAIRLSALFEAKDDGFTGIADQDKSFAHIAKVSGAEILSPDQTLVTPEAVATAHAMGRQVAPFTVNTSEGWQKMADAKVDAIISDDPVALLAWLRAQNPPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H6</accession>
    <name>E8X4H6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1240</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579626.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1240"/>
    <dbReference type="EnsemblBacteria" id="ADW68303">
        <property type="protein sequence ID" value="ADW68303"/>
        <property type="gene ID" value="AciX9_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1240"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_0"/>
    <dbReference type="OMA" id="IVIWFRA"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="33472" checksum="30DF8D4177575486" modified="2011-04-05" version="1">MNFTRRRGAIATAITLGSLLVGLAVTLNIAWIVNNEARLAYTILGVILFSILVAGVVLNTVFLVREVRRNERQDSFLNAVTHELKTPIASIRLYVETLQRRPLDEAQRQKFYSIMHADSDRLLATVEQVLKAGELGQRQRQQNRQHLDLEPLAADCIRITLERHHLPPEAITLDPVPGAVRLRVNGIAEDLRTAILNLLENAVKYSPNRVDIRVALAITNYTNAALTIQDHGLGIPERELKRIFKRFYRVPGRYEIKIKGTGLGLFLVRTIARQHGGSITAASKGANQGTTMTLTLPLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P9</accession>
    <name>E8X4P9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2422</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580775.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69459">
        <property type="protein sequence ID" value="ADW69459"/>
        <property type="gene ID" value="AciX9_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2422"/>
    <dbReference type="eggNOG" id="ENOG5033EX7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654931_0_0_0"/>
    <dbReference type="OMA" id="YFYSAIG"/>
    <dbReference type="OrthoDB" id="1124452at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230226" evidence="1">
        <location>
            <begin position="31"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="436" mass="45825" checksum="AAB0DB4F86FB5FDD" modified="2011-04-05" version="1">MNKAGVASLLAVSATLLVPGMVSNFGVALAQAAAAPAAGQVQMDPKEYAVYDDAVNKQTTPQTQAPALEAYLTSFPNSAVKADVLQRLMLDYSQFDPAKAITTADKVLQLDPNNLRADLIEVAFRRQAAETQTDATARQAGLDAAVTYAQKGLTATKPTGMSDADFTTLQAAAIPAFQSVIGTAALSKKDTATAITAFKAELAASKPEDTTKPGTALQDTYYLGQAYYQSTPPDLVNCTFYATRAFSYAPPQFQAQMPLAAYCYKKYHGGTDGYDAVTTAAKANLNPPSGFTIVAAPSDADIAAKTVASTPDLASLALSDKEFIMKNGKSEDAEKVFATIKGKTVQIPDALVIAATADDVQVAVSDDAVQGKAADFDFKMKTPLTKVPEVGSKINLAGTYDSYTQSPVMITMSDSDVVTKKAPAAATHHTTTTHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S5</accession>
    <name>E8X4S5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3560"/>
    <dbReference type="EnsemblBacteria" id="ADW70564">
        <property type="protein sequence ID" value="ADW70564"/>
        <property type="gene ID" value="AciX9_3560"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3560"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694010_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="397" mass="42480" checksum="01FBAC3C690C0D2E" modified="2011-04-05" version="1">MNSRREFVRWCAALSVSGVAVGDRGLFAQASGAVQGTATPASLAAVVALMTELMEKQGVSAGQIAVCKDGGLVLSKAFATKPPAGFAAVNSQSLFRIASCSKMFTCAAITRLRSRGDLDMDAKVFPMLGINAPAMPKDKPDPRIDEITVRQLVDHAGGWNDHESVVAKDGTHVPGTEWDPMSGTRQIALEMHLDRPATKLELAQYMYGKKLQFAPGSQNFNSTAKKSYSNVGYMLLGLVIEKVSGGPYLDFIRTELGPESDTSNVYLSRLLEKTKNPREVWYTSSRSGPTQLNPRSGEVLSEAYGGAYLPEQHESAGGLMTNAETLALFASKNAVWGLGGRSARSGRSGSLPGTSSFTCSRPNGVDGAFILNTRDFRDGEAKLDEFIGALQGLLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T3</accession>
    <name>E8X4T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3568</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581883.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3568"/>
    <dbReference type="EnsemblBacteria" id="ADW70572">
        <property type="protein sequence ID" value="ADW70572"/>
        <property type="gene ID" value="AciX9_3568"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3568"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_0"/>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="651" mass="73145" checksum="C9A3DE1BA72D11DE" modified="2011-04-05" version="1">MLQLSGAGKRFGQKLLFEDVNWLITPDERTGLVGGNGTGKSTLLKVLAGRESLDYGVSSRTKGMTLGYLPQDGLALRGKTVFEECLSVFDDLRGLEGEAEELSGKLAEFAPGSAEYEAAAARYGHVTDLMHAHDIYTLDYQVGTVLGGLGFGREDWERRTEEFSGGWQMRIALAKLLLEKPSLLLLDEPTNHLDLETRNWLEDYLRNYENAFVLISHDRYFLDQTVSKTTELWNKKAHFYFGNYEKYLKQKEERRTQIMSAYKNQQDRIQDLEAFINRFRAQATKAKQVQSRIKELEKIERIEVPEEEATIHFSIPQPPASGRTVIEVNNLTKIYPTRDGLGTKTILKDVSFSIDRGDRIALVGANGAGKSTLIRMLSQLEDPTSGEIKLGHNVLADYFAQDQYKVLDGAAKMLDDISGIAPKVPVVELRSLLGCFMFSGDDVFKTLGVLSGGERNRYAMAKMLVSPANMLLLDEPTNHLDLRAKDVLLDAIRKFSGTVLFVSHDRYFIDGLATRVFEVEDKRVHVYPGNYEDYLWRKQGGPEKVQSSFTAPKPEPVAVPVASVVVEAKKPAVKKLNPIKLKLLEDEVSAAEEAIGEWERRIEAAEAKLGVFTTADEQQRGSAELDRLRTEHAELLAVWEKLGMELEEQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X529</accession>
    <name>E8X529_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0146"/>
    <dbReference type="EnsemblBacteria" id="ADW67221">
        <property type="protein sequence ID" value="ADW67221"/>
        <property type="gene ID" value="AciX9_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0146"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_20_2_0"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9689" checksum="60CC2BA707B64A23" modified="2011-04-05" version="1">MHNLTTDSVLDELQPIFQEALDKPNLTVTLSSNAMNTPDWDSLAHIEIIEMVERHYKIKFGLGELQDLKDVNDLVKLTIEKVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X568</accession>
    <name>E8X568_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1270"/>
    <dbReference type="EnsemblBacteria" id="ADW68332">
        <property type="protein sequence ID" value="ADW68332"/>
        <property type="gene ID" value="AciX9_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1270"/>
    <dbReference type="eggNOG" id="ENOG5032V6G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143411_0_0_0"/>
    <dbReference type="OMA" id="PSSQWRM"/>
    <dbReference type="OrthoDB" id="1997771at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="16801" checksum="763CDB15466DD096" modified="2011-04-05" version="1">MSVNEAVRTRDVSGDAGAGAVAQERSWVLAWTSLFFILLQSVCSAFMAISGLRLLIGVGSLAAATSGAKFLDRIHGGPIRIPMMIFAVAGSVINLYSIWRARRLRARPSSQWRMQPLAPAKRRAEAIQIGIALMTLVLIGVEWVGHVRTFGGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A4</accession>
    <name>E8X5A4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1306</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1306"/>
    <dbReference type="EnsemblBacteria" id="ADW68368">
        <property type="protein sequence ID" value="ADW68368"/>
        <property type="gene ID" value="AciX9_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1306"/>
    <dbReference type="eggNOG" id="COG1643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_6_0"/>
    <dbReference type="OMA" id="DLRILVM"/>
    <dbReference type="OrthoDB" id="604268at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="202"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="778" mass="84922" checksum="B1EF589AC8CA733B" modified="2011-04-05" version="1">MTQKAAVPFALPIDEILPAILSSLARTPNLVIEAAPGAGKTTRVPPALLGLVQGEILVLEPRRIAARLAARRVAAELGEEVGGTVGYQVRFEEVSGPRTRLRFVTEGILTRRLIGDPTLKGVDAVVLDEFHERHLDGDLALALLKRLQVSRPELRIVVMSATLEAAAVSEYLGGCPMLRSEGRLFELAVRHMPYSPLTLAAQVRHGVELLTKDESSGHILVFLPGAAEIRKAMRECETVARKAGMIVLQLHGDLTPAEQDRVVSPSAERKLILATNVAESSVTIDGVSAVIDSGLARVASYSPWTGLPTLAVSRVSKASARQRAGRAGRTGPGRVLRLYSEEDYRQRADHDAPEIVRSDLAQLCLALRVMGLAGFDEIDWLDAPPPPAVERAEKLLDGLGAVGAMAEKMSRYPLPPRLARLVVESQARGVGAQGCLAAAMLSSGERSPQHDLLTALEAEHDGRTLQLQKQLGRIAHAKEGRDDDDALLLSVLSGHPDRVARLRAGSQVLLSSGGSAELDGEPPPYEFMVALEVEDRTEKPLPLIRMTARIEPEWLIDLFPERMREVSSLSWHRTAERVEAVETLLYEELIVQESRDSMPAPEAAAALLAEKMLEVGVTRFVEEAALADLNARIEVAGITPPDLSAVLNDLCFGKRSFAELKNSSADLLAMLEQAAGQSKLREAAPTSVKLPSGRQTKVHYETGKPPWIASRLQDFFGMTETPRIGPGRTPVVVHLLAPNHRAVQTTTDLEGFWTRLYPQVRRELMRRYPRHAWPERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G8</accession>
    <name>E8X5G8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2482</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580831.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2482"/>
    <dbReference type="EnsemblBacteria" id="ADW69515">
        <property type="protein sequence ID" value="ADW69515"/>
        <property type="gene ID" value="AciX9_2482"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2482"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_0_0"/>
    <dbReference type="OMA" id="MGDDFFH"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233704" evidence="1">
        <location>
            <begin position="28"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="447"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="734" mass="81162" checksum="03CEE387489A321E" modified="2011-04-05" version="1">MTVRVASVAGWLSLVAVSSFSIAQAPAKPSLQSYVGLYKVSADAGGTLSIYMDGAHLYEETEHDPKHELTLGAGVDSLQVEDAPLKMVFARDGKGNVTSFKAVRTDNSSTLFSGTRMSQEATRLNLPVGYEKIGVMIPMRDGVKLHAVVIKPKDSSTAVPFLMQRTPYGVDHYSVDSVYKSKPELAASGYIFVFEDIRGRYGSEGQFVMNRPIVNHVNKTDVDETTDTRDTIDWLLKNESGNNGAVGVYGVSYPGFLAMMAGIDAHPAVKAISPQAPMTDVWMGDDFFHNGAFRQTYGFDYVQQLEAQKTDARVESKGDTYDYFLKHVNFAGAAKDAGMEKLPTAVKFLNEPSYTKFWKDMGVEYHLTKVEVPTLEVGGYWDQEDMWGTQEEYAKLHAQDKDHKVFMVLGPWNHGGWGGPGNELGGNFGKLEFGEPTGDEYRKTIEAPFFEKYLKGKDGYDLMGVASFRTGINKWERYEAWPPPSGFKPAKVFLQADGGLATDAPQAPKDDAAAAKKKGLMDKIPFKKPSAPPIPKPGAPAKQMVVGTYVADPANPIPYRNRPIQATYGDGSKWRTWLVEDQKFVDARKDVAEFQGAPLAQDFTVTGDVMADLFASTTGTDADWIVKLIDVSPEGVQTMIVDEIFRGRYKESFETAHAIPANKVVEYKWSLHGADHTFLKGHRIMVEVQSSWFPLYDRNPQTFVANIMSAPAEAYQKQTVKIMSGSHLEFLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I1</accession>
    <name>E8X5I1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2496</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2496"/>
    <dbReference type="EnsemblBacteria" id="ADW69528">
        <property type="protein sequence ID" value="ADW69528"/>
        <property type="gene ID" value="AciX9_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2496"/>
    <dbReference type="HOGENOM" id="CLU_1508569_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="19104" checksum="E4DA6F0310E67A73" modified="2011-04-05" version="1">MRMNVRRDLRGALPMSLIAGAAYPVVRPEEIAFAMTLFLQAASLQLASRRCGDGRDSDDCECVRVLRELAGGIPLAAPKVLIAAQESSLEGAFAALWHHYEGEPVQLSLSARVLGFHLLALNNGGRILERWVRENVAGTETVTLDPALVEALAVVPLGDTGRLDAELFFATAELLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K7</accession>
    <name>E8X5K7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="2">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3631</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3631"/>
    <dbReference type="EnsemblBacteria" id="ADW70634">
        <property type="protein sequence ID" value="ADW70634"/>
        <property type="gene ID" value="AciX9_3631"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3631"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_0"/>
    <dbReference type="OMA" id="GTDIGRQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="94"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="441" mass="47491" checksum="22C1CC6860515A83" modified="2011-04-05" version="1">MAIRVALVNMAHTLTSEIDAATQAKAFPSSGGEMFGEYFAPGKSWNFTKSSLLDARARRILENTALACSVDAYPFHMPLEAKAGPSVIADGHPMLMLSSYDYLGLIGDPRIDQAATEAIAHYGTSTSGARLLTGTLASHRKMEQSLADLKGTEDCLTFSSGYLANLGAIYGLFGPGDRVIIDEYCHRSLHDACRMTGVQVQRFRHNDPQSAREELQKPNTANRTLIISDGVFSMDGDICCLPDLVALKKEFGCFLLIDEAHATGVLGATGRGTDEHFGIATSEVDIWTGSLAKSIPSNGGFIAVSQEVAIFLQHASSPYIFSAAVPAASVAAIAKGVEILKSEPERVTRLRRNGDFLRAGLQKLGYDTGLSETAVIPVVLKDEARTALFARRLRDHGIIAAPVMFPAVSQGLARLRLCVTAAHTMDHLEFVLDVFRKMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M2</accession>
    <name>E8X5M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3646</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3646"/>
    <dbReference type="EnsemblBacteria" id="ADW70649">
        <property type="protein sequence ID" value="ADW70649"/>
        <property type="gene ID" value="AciX9_3646"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3646"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_0"/>
    <dbReference type="OMA" id="CMDFELG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="228"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="36322" checksum="406824CC28C1A630" modified="2011-04-05" version="1">MSIRPQLEATLDPITDVFKTMHVTAFGLHRLEATAPWGVRQENQTEEITLAHRKTSPADLAHFAMLSRGNCWLSVDGIPDPIPLTGGDCFLLAKGTSIVMRDSPRTRPKWTFREIGASANGNVALCGGGGAPTTIVCGSLSFDRASLKPITQLLPSFILMKADQARTLALHNTVQALASEMAEQAPGSEVVATRLAEVLVIQLLRAHIASEPGRNRGWLRAVFDPQMGTALTAIHDRVNAPWTVESMAEAAGMSRSAFAARFKELLGETPLEYVTGWRMQKAMQLLQQRDKKLIDVARSVGYESDAAFSKAFKRVVGANPGEYLKRGFESTGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M4</accession>
    <name>E8X5M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3648</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581962.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3648"/>
    <dbReference type="EnsemblBacteria" id="ADW70651">
        <property type="protein sequence ID" value="ADW70651"/>
        <property type="gene ID" value="AciX9_3648"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3648"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056689_1_0_0"/>
    <dbReference type="OMA" id="MDKEWAR"/>
    <dbReference type="OrthoDB" id="1564715at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="32491" checksum="5D329050E30EE8C6" modified="2011-04-05" version="1">MANQETQILDEIIVSNRRKMLALGGAALAGLAFAGVTSASAQSAAPTDADVLNFALNLEYLEANFYNLAVSGQTIDQLGIGIGAGTAATGGGAVTTKPGGPTACKVAFALPQVKAYAIETAAEESKHVTLLRSALSTSAVAQPPIDLYNSFNTLGALIGVPNFDPFASDAFFLVGAYIFEDVGVTAYSGAAGLISTNSTLVTAAGILAVEAYHAGLVRTTIFQVDPTNSAGYLGITQKISALRNKLDLSATPDDYGIMATVTALNGTNVIGGGYSVVDANLTTSLAFSRTTSQVLAIVTGGTAGAYKGVFFPSGLNGNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N7</accession>
    <name>E8X5N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3663</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3663"/>
    <dbReference type="EnsemblBacteria" id="ADW70664">
        <property type="protein sequence ID" value="ADW70664"/>
        <property type="gene ID" value="AciX9_3663"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3663"/>
    <dbReference type="HOGENOM" id="CLU_1445782_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233714" evidence="1">
        <location>
            <begin position="35"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="19579" checksum="1C524D752A6D5EC5" modified="2011-04-05" version="1">MKGFQYGRVPRKAAGLWFGVGLAGTLFAVCGAQAAGHGPVRVKGTKPPLVLRQYGRVTYLEGSGLKLALTHPGVRPQGLNAPFGAAQVFAKPGHVLIFTDSFASNPGNVQGECGASETGERYLHVLALGQPKETLSVLVESCWLNMVPAHAPKWDAAAGTVTVDLLSNDKGPLHSVYRVGADGAVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T9</accession>
    <name>E8X5T9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4027</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572735.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70823">
        <property type="protein sequence ID" value="ADW70823"/>
        <property type="gene ID" value="AciX9_4027"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4027"/>
    <dbReference type="HOGENOM" id="CLU_141551_1_0_0"/>
    <dbReference type="OMA" id="AHNTIFR"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230758" evidence="1">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="16239" checksum="C89670159FFE4BB1" modified="2011-04-05" version="1">MNNPSRRDLCVALAALASVGTASAETQPTSAPETGPRLLHSELFPFDKLIAKPSANGGASRAVVHGTLATGEFVEVHETTLPPGQMPHPPHRHTHSEFLLIREGKLQVDSDGQRGVIEAGGVIFTASGVLHGLKNIGDVPANYFVVAVGLQKALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X8</accession>
    <name>E8X5X8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4079</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572774.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70862">
        <property type="protein sequence ID" value="ADW70862"/>
        <property type="gene ID" value="AciX9_4079"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4079"/>
    <dbReference type="HOGENOM" id="CLU_008973_4_0_0"/>
    <dbReference type="OMA" id="KWYPGES"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018667">
        <property type="entry name" value="DUF2126"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09899">
        <property type="entry name" value="DUF2126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121523" checksum="473FB72914FA64EE" modified="2011-04-05" version="1">MTIDLELHHRTAYHYERAVSLGPQVIQLRPAPHCRTPIRSYALALQPSGGAVHWQFDALGNPLARVLLAEKITDFLVDVTLVADMTPINAFDFVLDSGFEMFPFQYPAEMARNLEPYRAVEQPGSRFQALLNEIPASPCGTVAFVGDMTSYVRDRVGYTTRMEHGVQSCEQTLTTLTGSCRDSAWLLVQVFRSFGLAARFVSGYLIQLAGEQSESGEWSGPKADTADLHAWAEVFLPGAGWIGVDPTSGLFTAEGHIPLVCTPSPGEAAPISGTVEPAAVEFSHTLTVRRLNEAPSLERPFSDDAWQRVRTVAHTVDASLREQDVRLTMGGEPTFVGIDEPESPQWNLEALGDIKRNRAMVLIRRLRERTAPGGLLHFGQGKWYPGEPLPRWAFHCISRTDGVPVWEDADWFAHDDVASSFGDADSLRFLTALARRLQVSEENILAAFEPDSSADAESVGYILPLRRRQPEGRLAWSSQLWFPRPDRLTLFPGDSPIGYRITAELVPFVAPDELKHTMEGEGEDALVKLPGRPAHRPELFAIAATPDPLPPLSSTAENAPELVRPALCVQAVDGQLHVFLPYTPVVADYLDLVAAVEDTCQHLSMPIWLEGYTPPHDPRLRNYGLTPDPGVLEVNLPPTSDWDTLEELNETLHEEAHAHRLIAGKFAYDGSHLNTGGGSHIVLGSSSVLQSPVLRRPDLLRSMVTFWQRHPSLSYLFAGMYVGPTSQYPRVDEARVDALYELEVAFSQLRDRAECPPWILDGLFRNLLVDVTGNTHRAEFCIDKMYPPEGQGLRAGLLELRAFEMQPHYRMGLLQMLLVRALVSVFWKQPCTDSLIRWEATLHDRFMLPHFVREDFREVLASLRQAGFAFEDDWFQTHAEFRFPRIGAVHGEGFDLELRQALEPWNVLAEETSSGRTGRSVDSSLERMQVKLTQPSGESFGSRLIVTCNGRRVPLVPTGVPGEMVAGIRYRARMLSAALHPTIPVHTPLVFDLIRTDALGTSTVSQGRSIARSIARCTYFAGPPDGSVHTTRPRDAEQAQARRNERFVVSEPPSGPMPLPPDERNPIFPMTLDLRFPQPVDEKDRPNPEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X613</accession>
    <name>E8X613_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4117</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70897">
        <property type="protein sequence ID" value="ADW70897"/>
        <property type="gene ID" value="AciX9_4117"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4117"/>
    <dbReference type="HOGENOM" id="CLU_1684090_0_0_0"/>
    <dbReference type="OMA" id="NDIATRC"/>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="17375" checksum="46B60C63D6615A02" modified="2011-04-05" version="1">MTNLASLEYRRAATQQASVVGLVIALHDTLIGNLKRAADAMDRNDIATRCDQLIHGFKVITQLEAMLDRNNGGAAAVSIERFYKHVRAQMLNAQFKLDPAILRDQVRVVMEVRQAWQQVDSAPMEARRTQPNYPSAPVEILQPIETEAHTSFSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X675</accession>
    <name>E8X675_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4180</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70959">
        <property type="protein sequence ID" value="ADW70959"/>
        <property type="gene ID" value="AciX9_4180"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4180"/>
    <dbReference type="HOGENOM" id="CLU_018816_2_0_0"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="104"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="442" mass="46826" checksum="0B46B98C835CBAAB" modified="2011-04-05" version="1">MGASFEAHNSESYGGDVGRSFTEKNGEEERHKREHKSHAWIWITAIIVIVVAILLVERGKSDKTSTKAGAGGAAAGKSGGGRGQQGPAAITVGQSKTGNINVYVDALGTVTPTNTVTIYSQITGKVMAVYYREGQIVRKGQPLIDIDPRPYEATLTQAEGTLQHDQGVLAEARIDLERYQIAFSKNAIARQQLEDQQQVVLQDEGTVKTDEGTVAYDKVQLSYCHIVSPINGRVGLRLVDPGNTVFSGTGSTLVVVTQLQPITVVFNVSEDDLPAIQAQLKGGRTLEVDAYDRANDKQIEAGKLNSLDNQIDTTTGTVKFRAGFNNTGLTLFPNQFVNARLLEKTLKGTVLVPSAAVQHNGTQAFVYVVKPNKTVGVQNVTALTSDEKDTAVQGLGAGTDVATSGFDRLENGVPVLINQKAPGQAAAQGHGSNGSAGGSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J0</accession>
    <name>E8X6J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4306</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71074">
        <property type="protein sequence ID" value="ADW71074"/>
        <property type="gene ID" value="AciX9_4306"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4306"/>
    <dbReference type="HOGENOM" id="CLU_650146_0_0_0"/>
    <dbReference type="OMA" id="PRIFAEW"/>
    <dbReference type="OrthoDB" id="1773025at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234246" evidence="2">
        <location>
            <begin position="24"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="46947" checksum="385EFD31D142CBE3" modified="2011-04-05" version="1">MKFHCTHLFIALTAAMVTVPSLAQDAKALRAQANTEPNQEKQVILLCKAADMEPKNKDFRKDCDVSRAALINSDKQALKTALDANDAGQAAKAKRYAKYVSNLDPDTHHQAEQLLAKLNGPGPDAPTTALTKPADQSGALLSQAMTAFDSGNLSAARTAAQGVTDPSIKPAATRLLGEIDRYGSLVSTGHSHEDSKEYAQAERSYQSALDLNGHVGSDDLSGKIQRMHQMAAVAAAPVTQAQAPVVIAKNVPPPPPPVSKPAADQKALNKPPDVSPDEKKRKLLEEASLAVSHKDSETASRKYRQVLDIDPANADAKREIARINAEVAAELSRDPVKLETTLREAITAFYSSHFEDAESRLNRYLGADGGKKKGAAYFYLGATEETLAYLDPAAKRATRQKEAQEDFKQARSAGYQPVAKYVSTRILEDWKNPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J1</accession>
    <name>E8X6J1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_4307</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71075">
        <property type="protein sequence ID" value="ADW71075"/>
        <property type="gene ID" value="AciX9_4307"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4307"/>
    <dbReference type="HOGENOM" id="CLU_011521_0_0_0"/>
    <dbReference type="OMA" id="TFHYIAP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="377"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112181" checksum="EF2A7FC51DDF1F14" modified="2011-04-05" version="1">MDTPSSVTHIGKYEVLSELGRGGMGVVYRAEDKNIGREVAIKTLTDATPELRQRFQSEARTGVLNHQNIVTVYDFGEQDGNPYIVMEFLHGESLEKVLRNNTLTIVDKLDIVRQVCNGMGYAHSKGVVHRDIKPANVMVQPDGNAKIVDFGIARLESSSGHTQTGAVIGTFHYISPERLKGHPSDGRADIWAAGIMLYQMLTGVLPFGGEDISALHKVVNEPFPPLGTYLQDYPTGLDMVLDRALAKDPDERYATAEEMAGDLEALNETLKRARVGEMLGQVKMLLEQEKLTSARPLLIDLQRLDPQNFEIRKLLREVQDRLARQQKSEQVRQTLNQAEEAVLGQRYVEALELYKQAARVDPNANGLTEKIEHVRGLKEKVDKIASLQQQARDARHRSDFTAASQLIEQALQLDERNTDLRNEKAGIVQEMQRQAKDGTRRKLKESGKDLLSNRDFTGAIKNLREALDIDPTDVEAQKMFQEATARQEEDRRRKVIDQIVAEIQDSLFRGESDRALQLINRALDRLPAEAQLLRLKGETEKKLQEEHARKLVESTSLKVQELFFSNPQEALSCIQKALDEIPGEERLLALQERVVDQLKKANLEGLRAQYLKHAQTSLDAAQYDQAISTLETAALDCGETPEITYLLEHARTEKLNKERSQAAAAVLEEAHRKLAAEDLEGAIAVLKPAAQQGGTPAIEQLLRQTQERLDEIGRRMEAVIARVQSLSETDPAQALQLLNSQPAAVQQHSQLKAIRAKIEGRAEQQRAIQASIAQANELLNKRDLRGGLEILEAVRNAYGDSPEITAVVTDYKRRQVPIANAMVGESISQARQAILAKKGPLALEELRKSAEVLAVSDANLQADWNRLAQEAAKVSKARLDTTGSVPIIVQSKGLSSMLIGILAAVVLIVAGAVFYVIHTRSNTGGGAAMSFIQLNASPFGEVVSITGSSGNVVLLPAGSHMTPLRVDAVPEGTYTVVFKSSDGSTQQQTCDLAADHMCSATFTTLGDSQIDEILAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L4</accession>
    <name>E8X6L4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3883</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71164">
        <property type="protein sequence ID" value="ADW71164"/>
        <property type="gene ID" value="AciX9_3883"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3883"/>
    <dbReference type="HOGENOM" id="CLU_2508075_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9297" checksum="A95FD5254478EE8B" modified="2011-04-05" version="1">MNIIAFCCISRGEVEEDGCPAYGGGRVLRIEGINMSGANAAANYSFSEEAFSVLDQILSSSDQDQLSEVLILDQQRFKRLAARIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P4</accession>
    <name>E8X6P4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3918</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582212.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71194">
        <property type="protein sequence ID" value="ADW71194"/>
        <property type="gene ID" value="AciX9_3918"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3918"/>
    <dbReference type="HOGENOM" id="CLU_142057_0_1_0"/>
    <dbReference type="OMA" id="IRHLGYP"/>
    <dbReference type="OrthoDB" id="1753156at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14806" checksum="0DAE212262493F6E" modified="2011-04-05" version="1">MKTSKRLTVAFWIVTVLFCLEMSFTAYYELLVLPQAAHAFTRLGFPTDSFRVELSWAKIVGVLALLIPAAPPRLKEWAYAGFAINLISALIAHISIHDRTAAFIPSSITAVLWTFSYISWRRLETERGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X783</accession>
    <name>E8X783_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4365</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573036.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71317">
        <property type="protein sequence ID" value="ADW71317"/>
        <property type="gene ID" value="AciX9_4365"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4365"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="VAKPIGM"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="14652" checksum="2EAAA3443FE6FF81" modified="2011-04-05" version="1">MENMKLKHIFVVDDERIIAETLTAILQKSGFSARAFYNPLDALAAAASAAPDLLISDVVMPQLSGVELAIQLTKLCPDCKVLLFSGQAQTADLLLDARQLGHDFSLLSKPIHPSDLLKQIRSQEALSPKNLAVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C1</accession>
    <name>E8X7C1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4405</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71355">
        <property type="protein sequence ID" value="ADW71355"/>
        <property type="gene ID" value="AciX9_4405"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4405"/>
    <dbReference type="HOGENOM" id="CLU_025126_1_0_0"/>
    <dbReference type="OMA" id="YPSSHGC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016915">
        <property type="entry name" value="UCP029342"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029342">
        <property type="entry name" value="UCP029342_ErfK/YbiS/YcfS/YnhG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234479" evidence="3">
        <location>
            <begin position="31"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="66"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="34974" checksum="3A5490F44253A218" modified="2011-04-05" version="1">MNTERLRRRFLRNFVGALICLGAVTGPSWAQSSNALSSDLAGGIEALKPGQYLWAPMVAPSGPVLAVISLKSQRVYVYRNGVLIGVATVSTGKPGHQTPTGVFTVLQKKVHHKSNLYDSAPMPYMERLTWSGVAMHAGNLPGYPASHGCIRMPMAFAKLLYGTTARGMTVVITELDEVPRFAPVPDLLQSEASSKAEDAGGAIWAPQKSSSGPVSLILSAADHRLVVLRNGVLIGSTPVTVTGAVTETTAYSLSKVDTLGYHWVQLPLPGQSWVGTRELPISERSRVTMPDAFRSALDAVLSPGVTLVVTSDSLLASGTGKSLTVIESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I2</accession>
    <name>E8X7I2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4470</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71416">
        <property type="protein sequence ID" value="ADW71416"/>
        <property type="gene ID" value="AciX9_4470"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4470"/>
    <dbReference type="HOGENOM" id="CLU_1473219_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="20767" checksum="48DDDE4662DE6EAA" modified="2011-04-05" version="1">MPRLDLRPALRATMTTKHNSSDVYDRDFMESVAIGVPAANSSDQVFDEWISGAARELCDAGNWFYTSVKQTAEPSDHKASSDENFKVLWPRQRLRLQIVVSSSTRIPLVYVESDTGVLLGHLNAKRSQQVSQDSQMGYNFLAVVCRWFSPIPKDSPGLVIVVLRLHRDWETSDWAVTHRLYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P9</accession>
    <name>E8X7P9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4547</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573202.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71483">
        <property type="protein sequence ID" value="ADW71483"/>
        <property type="gene ID" value="AciX9_4547"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4547"/>
    <dbReference type="HOGENOM" id="CLU_849322_0_0_0"/>
    <dbReference type="OrthoDB" id="1074108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006881">
        <property type="entry name" value="RepA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04796">
        <property type="entry name" value="RepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="37314" checksum="F5016A5930F3A794" modified="2011-04-05" version="1">MKRTIEPPIIEVVADRPKTKRNPTLERKVAKERLATRLGDIAVARHEGSLGDEYIKLAQAMILCTLPYSETKETRITRQARLGDGSILSVTFSASAPDVPLPFGADRKLLAWLFDRAIRSDSSFIPWTSATEYQRETGLSIGGSGNRDLNKRFMRVAGLVINIQRKADRTKHDITYPIIERSFLPASITGQRASDEGQSSLPEMGDRFGFQLNAGLFEDIRRHHIVLPRKIWLELSGATQVQDLVYWLIFRCYSAASESVIPWAALSEQFPQDKNPRRTRANARQAIRILTTLWPSVQIREVPQGIWVNHTPEAMLEDDVTKGRVRKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y5</accession>
    <name>E8X7Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4639</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573288.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71569">
        <property type="protein sequence ID" value="ADW71569"/>
        <property type="gene ID" value="AciX9_4639"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4639"/>
    <dbReference type="HOGENOM" id="CLU_041527_3_1_0"/>
    <dbReference type="OMA" id="NYSNVAQ"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="182"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="43202" checksum="4347CD66F92C1856" modified="2011-04-05" version="1">MDIQRIDRNLVEAALKHQAAVAIIGPRQVGKTTLARDIADHHQGSLYLDLEAREDRDKLTEPVLFLREYENALVVLDEIHRVPEIFSSLRGLIDQGRRTGRGTGRFLILGSASIDLLRQSGESLAGRITYVDMGPFNTQELPVDEPTLLKLWLRGGFPGSYLAPDDGTSLRWRTDFIRTYLERDVSEFGPRIPAGVLERLWTMLAHGQGTLLNTARLASGLQVSAPTVGRYIDLLSNLLLVRRLAPFHRNDGKRLVKSPKVYVRDSGLVHALLGLKTYNDLAGHPVTGSSWEGCVIENLLAAAPERTVASFYRTAAGAEIDLVLEIPGHGMWAIEVKRSLSARPEKGFYIACEDLKPDRRFVVNAGITEYPIGQATTAIGLAGLTQVLAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X848</accession>
    <name>E8X848_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4705</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71632">
        <property type="protein sequence ID" value="ADW71632"/>
        <property type="gene ID" value="AciX9_4705"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4705"/>
    <dbReference type="HOGENOM" id="CLU_1737991_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16958" checksum="35D91AC5E8F9895C" modified="2011-04-05" version="1">MLGLALAGVHEPYATTVTNRWKAVGFPPLRSFAPYFSYVCSVDLTFFLATAAGLVRDADRPSNKVDIAYLYYLPFCTVFTSKDRLHKNLAPLFLHSMQNFISGDEMKADLARLNARYSALPKETKLKGMMNFASEPPDDESFLTTRMWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD2</accession>
    <name>E8WVD2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579703.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68380">
        <property type="protein sequence ID" value="ADW68380"/>
        <property type="gene ID" value="AciX9_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1318"/>
    <dbReference type="HOGENOM" id="CLU_982675_0_0_0"/>
    <dbReference type="OrthoDB" id="2157967at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="31064" checksum="B1CA60695130DA67" modified="2011-04-05" version="1">MSVTVLIKDANVYYLCKNGGDASTNHDLLALPGMAAVDFTGMAALTTFTISTKRSVVGSAAEWLNVSDDAFLRFKNGGKRLPSETEKLVVHDGGVALKRQRLDRESKPVMEGDVGPYARGAGNLKKGNLTTATNSKPTAWAVGTAGTPAYFETDPSHPNDLNRDHQNNAASLKKRKRDDRDGMTIAIPQWIHMNGYTFGNKAKAGKIKKGTTLSRTEWISQNPSPAFFKEVYQTIRFYADSGNLTYETVGSYRYLYKRNTQLGTCSATSDLDQLFMHYLGLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ2</accession>
    <name>E8WVQ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2551</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580896.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69581">
        <property type="protein sequence ID" value="ADW69581"/>
        <property type="gene ID" value="AciX9_2551"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2551"/>
    <dbReference type="eggNOG" id="ENOG5033PC8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153796_0_0_0"/>
    <dbReference type="OMA" id="YLGVEQW"/>
    <dbReference type="OrthoDB" id="1574510at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="15801" checksum="8EBEA3384AEBFC5D" modified="2011-04-05" version="1">MKTILQILKQAGGWHHGLYLKIENPPYMALVIEATDESGPCGLPAISVCHYGEQNGDLMRDPEMCFEFGLAGGAHLNPFYYRNDYVGVEQWSRNIVGDHYVYLTSLHQQHERLAKVWDNNLRLQGFAEAFEQQHTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU0</accession>
    <name>E8WVU0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ordered locus">AciX9_3698</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582008.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3698"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ADW70699">
        <property type="protein sequence ID" value="ADW70699"/>
        <property type="gene ID" value="AciX9_3698"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3698"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_0"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="499" mass="54121" checksum="F3B8948723EF1A0E" modified="2011-04-05" version="1">MNTTLSLAQDMQDHEADDHLDKLREECGVMAVYNHPDAARLTYWGLYSLQHRGQESGGIASADGEHVNDIKGMGLVSEIFTDDVLQKLPGHLAIGHTRYSTTGDSALLNAQPISVESTKGLIAIAHNGNLINLGTAKERLERDGAIFQTTSDSEIIIQLVAHSKCTTLVDCMAEALAQVEGAFSIVMMTRNRIFAARDPHGFRPLCMGRVTGEDGAPDTFVFASETCALDLLHAKYERDVEPGELVMVSEDGVTSRHFAKGSVPPASCVFEHVYFARPDSKVFGRWVQKSREEMGRQLARESAVPADLVVPVPDSGVTAAIGYAAESGIPFNFGLIRNHYVGRTFIEPTQRVRDFGVRMKLNPSRALLEGKRVILIDDSIIRGTTSRKIVRMVRAAGATEVHLRISCPPTISPCFYGVDTPSREHLIAANKSLAEICAYIEADSLAYLSLVGLTHSCTTGEPLGGLSPASFCTACYTGEYPTQMIDVSEILPAPAMPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU5</accession>
    <name>E8WVU5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3703"/>
    <dbReference type="EnsemblBacteria" id="ADW70704">
        <property type="protein sequence ID" value="ADW70704"/>
        <property type="gene ID" value="AciX9_3703"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3703"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615273_0_0_0"/>
    <dbReference type="OMA" id="TTHGGYT"/>
    <dbReference type="OrthoDB" id="1974001at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="50974" checksum="147AF6970EA2CAE1" modified="2011-04-05" version="1">MQAVLRWMRAEDDPLRLPSRLFWVGLALRVAYITLAHTYKIRLILDHFQFGWEMGRIARSLATGYGFANPFNGHSGPTAWTPPLYPLLLAGVFKVFGVYTLKSAWVILTINSIFSAATGCAVYEIAWRCFGRDAKGLKVALWSGWLWALYPAAMQYAVHWVWDMALTALLFSWVLVLALRVRAVGDPTETNPQSARRWLLFGVLWGVIALSNSSLLTFLPACGLWMVWPELTGLPRHVLRALRNAVLAAVCCLAMLAPWVARNWYTFHAFIPMRANLGAELYQSVLQTNDGFPWGGTLSLAEADPEFQRYEHMGEVAFSKAQGERAKEIIRRDPRTFARHAALRVFFFWVSVPHPVEKSVFIEATREANYAFLSLAGLLGLALALHRRVPGAWLFFWAFALFPLIYYFITVQARFRHPLEPIITVLAVYLFQSAELPSEKRRRLAEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU9</accession>
    <name>E8WVU9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3707</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582017.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3707"/>
    <dbReference type="EnsemblBacteria" id="ADW70708">
        <property type="protein sequence ID" value="ADW70708"/>
        <property type="gene ID" value="AciX9_3707"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3707"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_0_0"/>
    <dbReference type="OMA" id="QVMRTRQ"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11802" checksum="93EAFD09E9711003" modified="2011-04-05" version="1">MQTIITENQEQIAELCRQHHVRSLAVFGSAARDDFDPARSDVDLLVEFGPLSDLEYAPNYFSLLRSFDRLFGRRVDMLTDPSIRNPYLRKSIECDKVYLYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW28</accession>
    <name>E8WW28_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydropyrimidinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0260</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0260"/>
    <dbReference type="EnsemblBacteria" id="ADW67334">
        <property type="protein sequence ID" value="ADW67334"/>
        <property type="gene ID" value="AciX9_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0260"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_2_0_0"/>
    <dbReference type="OMA" id="RNFVCSP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="49"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="468" mass="49885" checksum="F67CE3DA6B596844" modified="2011-04-05" version="1">MSVLIQHGTVVNAGGSVKADVLIEGERIVAVAAGLDPAGHTVVDATGLLVMPGGIDVHTHLDMPFGGTTSADDYFTGTRAAAVGGTTTVFDFALQSHGHTLGDALTVWRGKAAGKACIDYGLHMAITDLNPHGGSEHETLREMDAMVAEGITTFKLFMAYPNVLMIDDGLMFRVMQHAAELKALCLIHAENGAAIDVIVAQALAEGKTAPHFHALTRSTQAEAEATHRAIALAEMAGASVYIVHLSNTDSLRELKAAQARGLKALAETCTQYLVLSLEEQMPGKSFDEAKYVFTPPLRSKTNHAPLWEALADGSLSVVSTDHCPFRFEDQKALGKDDFTKIPNGGPGIENRLQLLWHYGVNAGLLTPERFVELTSSAPAKIFGLPQKGQIAAGFDADVLLWNPNAEYTISAATQAMNTDYSMFEGWTVKGNASKVYSRGKLIVDEGRFVGEAGYGRFLRTEANAGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW56</accession>
    <name>E8WW56_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0290"/>
    <dbReference type="EnsemblBacteria" id="ADW67362">
        <property type="protein sequence ID" value="ADW67362"/>
        <property type="gene ID" value="AciX9_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0290"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027791_0_0_0"/>
    <dbReference type="OMA" id="RAQLWMA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="648" mass="70157" checksum="431A15D14686F1DE" modified="2011-04-05" version="1">MSRDNVVSIKPEPEDINVPASIAEIAASPDLTPQEAGDQSQPPVDGIRAFDEQGREILVPREEWSTNVLPNMILQAWDQPDQLYMVILNSLNDGFATEVIAAAEHLAETDTIPARGACMWGIVLLQQGRLDEAESLLAGFTEKNGEDASVLTNLAKVYAAQDKQELTESTLWRALELEPNLDNGLGWYASMAQERGGDQAAADALERIRQLPGSWRAQLWLARGLLNGNNLDGAKVYYNEALERAPKPIPGDFLMQMSGDLGGHGYLRELLEFTIPHFVPELHGLAVGNNLIKACIDTGNLDPADEIRRALDAFNRPDWRQPLAFWDQEIGRQRAARAAGTQPGTAQDVQLGMLRVDGPIWLPLQSPARKLFGQKTTAGPSVTFLGGTAEAPEEAQTAPTSPEAAQSMAETLDALGRLTRALPLFLAEQVEMLAAASGRAMLPWAVGAPGRAGGFVVSGQRWPDEVAVQSANADANKSDYVVSVHIDAEVEPWTADLAFVRTSDGTRIGELSQEFNVANPEEGLRALAAETIELLGAASWSGDSAQYHVPDATDFTAYLQRLEQLLALRCAGMEGVPPQFLNGEREIMNGALDLARAEPHNMVARVLLIETLVAMRPIRPELAQEFAQQVEALATTHPLPTVTAAFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK1</accession>
    <name>E8WWK1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2640</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580980.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2640"/>
    <dbReference type="EnsemblBacteria" id="ADW69665">
        <property type="protein sequence ID" value="ADW69665"/>
        <property type="gene ID" value="AciX9_2640"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2640"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_5_1_0"/>
    <dbReference type="OMA" id="MVVYPYG"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="30948" checksum="48B86BDE6246B214" modified="2011-04-05" version="1">MASLVRNTAVTLEMIKWEHSIFALPFALTGAVLAAGGWPPAVKLLWIVVCMVAARSAAMAFNRLVDATLDEANPRTKMRAIPAGQLSWGFVAGFVVVSSAVFLVAAAMLNRLTLELAPVALVVVLAYSYMKRLTRWSHLVLGLALGIAPSAAWIAVTGSLDPRIIVLTGLVMLWVGGFDVLYACQDFEHDRAVGLNSVPAAFGLEGAFWIARVMHLGVVGLAIWLDRLFGLGVVGYVGTAIVAGLLVYEHCIISPRDLRRMNAAFFLLNGIISVVFFLFVAGAVVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM1</accession>
    <name>E8WWM1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3766</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582074.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3766"/>
    <dbReference type="EnsemblBacteria" id="ADW70766">
        <property type="protein sequence ID" value="ADW70766"/>
        <property type="gene ID" value="AciX9_3766"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3766"/>
    <dbReference type="eggNOG" id="COG1023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_0"/>
    <dbReference type="OMA" id="PEYYQYD"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="36558" checksum="27F6BE1A7163F917" modified="2011-04-05" version="1">MQLAMVGLGRMGANMVRRLAANGHECVVFDMSPKAVEDLAKTDGVTGSTSMEDMLSKLSKPRAIWLMVPAGVVDKTIEQLEPHLEAGDILIDGGNSYYIDDIRHAKRVAEKKIEFVDVGTSGGVWGLERGYCMMIGGSDKTVEYLDPIFKTLAPGIGTIDRTPGRPENKGTAELGYLHCGPNGAGHFVKMVHNGIEYGMMAAYAEGLGVLKAANVGKHAGEIDAETTPLRDPEHYMFDMDIPEITEVWRRGSVVASWLLDLTAGTLAQDPELSKFGGRVSDSGEGRWTIKAAIDEGVPTPVLTASLYSRFSSRGEAEYSNKLLSAMRYAFGGHLEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP9</accession>
    <name>E8WWP9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0305"/>
    <dbReference type="EnsemblBacteria" id="ADW67377">
        <property type="protein sequence ID" value="ADW67377"/>
        <property type="gene ID" value="AciX9_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0305"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_1_0"/>
    <dbReference type="OMA" id="YRYEPHR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="436" mass="48385" checksum="DC722F858B77F4A9" modified="2011-04-05" version="1">MPQPDRFGFLHIDLNSFFASVEQQLHPEMRGKPVGVCGTMADTGALIAASYEAKALGIHTLTKVGEAKRICPEIILVNGSHTEYSRFSHEIAAAVERCCPVAHTPSIDEMVCQLMGRECEPPNARRIALEIKQAIKDDVGDTLRCSIGMAPNRYLAKIASDMQKPDGLIGLLPSQLPRAIAHLELRDLPGVGAKTEERLNGKGITTMEQLLALDRTGMHRLWDSVWGDRLYHWLRGGETGDDGAPVASEVQKSLGHSHVMGPEFRSDGGAWSVAHKLLHKASMRLRMEKFYAGAMTVTIKYALTTEQAGRMGAKKHSSGIKSKGWAMEARFKDCQDTLSLLDVLRNVWKQRPRGEEFERPFFVGVTLRELIPEDEHQASLFGDPDNRADLSKTMDKLNLKYGHTTLHFAGMLPARDTAPTRIAFTQIPVQYGVEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS6</accession>
    <name>E8WWS6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnS</name>
        <name evidence="7" type="ordered locus">AciX9_0332</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578732.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0332"/>
    <dbReference type="EnsemblBacteria" id="ADW67404">
        <property type="protein sequence ID" value="ADW67404"/>
        <property type="gene ID" value="AciX9_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0332"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_0"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="138"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="49866" checksum="42D19DDE99FB47E8" modified="2011-04-05" version="1">MSEAVITARISELAAHEGQSVTLKGWLYNLRASGKLLFPIFRDGTGTIQGIVPKAAVPEELFETLKTLTLESSLEVTGKVRADARAPSGFELDVEGLKVIQRVPDETPFPIQLKEAGVDFLMEHRHLWIRTPRQSAILRVRATIMRAAAQYFDDNGFVRTDPPILTPNACEGTSELFEMDYFDDDKAYLTQSGQLYIEATALALGKVYSFGPTFRAEKSKTRRHLTEFWMVEPELAFATLDDLLVLAENYLSFIVAAVLEKHQADLKVIGKDVSKLETIKAPFPRLSYDDAHKMLVEAHAKGLVETLHKDGDDFGSPDETYISNQFDRPVMVHRYPSAMKAFYMQPDPEDPTKALCVDVLAPEGYGEIIGGSQRVDDYDLLKSRIEHHGLPLDAFQWYLDLRKYGSVPHGGFGMGIERVVAWICGLDHVRETIPFARTLNRIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV5</accession>
    <name>E8WWV5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ/DHR/GLGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0361"/>
    <dbReference type="EnsemblBacteria" id="ADW67433">
        <property type="protein sequence ID" value="ADW67433"/>
        <property type="gene ID" value="AciX9_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0361"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073806_0_0_0"/>
    <dbReference type="OMA" id="HEVETNS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="200"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="33723" checksum="1D80C407F8132951" modified="2011-04-05" version="1">MDRRLVVGVIVVAAGLGLASAAFGLGRPRGVVAGLHGAGSHTVPGYLGINVRTVSEERVAALKLKDGRGAEIVQVDHDGPAGKMGLREHDVVLQMNGVAIEGEEQMRRMLRDMPPGRNVSLVIVRDGSGQMTVTAQMADRTKVEQQAWANHLRPGDAVGGGPQALAAGLPAGSVDDEVIDGGTVGPPVNGGKYSKGFLGTLLMSPSYTGVVLEKMGPQLASFFGSQNGRGLLVRSVEVNSPAAQAGMQAGDVVVKANAQMVASMGDWAKQIKEAKGHPVTVTVLRDKSERTLTLVPDGKKRSGLERKGTGYDMAGDGVVVAGLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV8</accession>
    <name>E8WWV8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578764.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67436">
        <property type="protein sequence ID" value="ADW67436"/>
        <property type="gene ID" value="AciX9_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0364"/>
    <dbReference type="eggNOG" id="ENOG5030N7Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168133_1_0_0"/>
    <dbReference type="OMA" id="TPGIDQR"/>
    <dbReference type="OrthoDB" id="2094073at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234116" evidence="2">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="12937" checksum="C260D7FE53AE9349" modified="2011-04-05" version="1">MKLTSLFLAVSLAVAPVSAAFAQHTTYAQRHSIRARQTNQQARINHGVRDGQITPKGAAHAEANQARISSEEHSMRAADNGHLTAQDRHTVARQQDRTSKGIYDRNHNGYTDPGVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX1</accession>
    <name>E8WWX1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1479</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1479"/>
    <dbReference type="EnsemblBacteria" id="ADW68532">
        <property type="protein sequence ID" value="ADW68532"/>
        <property type="gene ID" value="AciX9_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1479"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="IMITARV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="28625" checksum="379759CDD45B42FF" modified="2011-04-05" version="1">MRVLIVEDDAALGIFLQKGLKLEGHDVQLVGDGQAGLDHAMEHAPDLMVLDLSLPKKDGIQVLEEMHGHFGGTSVLVLTGRNQVSDRVKCLNLGADDCLLKPFSFSELNARCRALLRRRQHSADQTLRYAGVELNRIDRRVTRDGLSIELTGKEFALLEFLMQARGRTCSRSELLREVWQMSPDAGTNVVDVYVNYLRKKLGSTRSGIGADRVIETVRGEGYMMSMGTERRPPGAAVPDGLQGSLRGPGAGVFGLGLGARASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ2</accession>
    <name>E8WWZ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1500"/>
    <dbReference type="EnsemblBacteria" id="ADW68553">
        <property type="protein sequence ID" value="ADW68553"/>
        <property type="gene ID" value="AciX9_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1500"/>
    <dbReference type="HOGENOM" id="CLU_206036_0_0_0"/>
    <dbReference type="OMA" id="ITFMMLA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="7204" checksum="8BF3130F7EB38AF0" modified="2011-04-05" version="1">MIRFFVVLMLMCPPVLYGQGCSQCREAVGQTPARTQVAYRRGITFMMLAGAGVFAGAVLAMRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX86</accession>
    <name>E8WX86_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ordered locus">AciX9_2704</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581043.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2704"/>
    <dbReference type="EnsemblBacteria" id="ADW69728">
        <property type="protein sequence ID" value="ADW69728"/>
        <property type="gene ID" value="AciX9_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2704"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_0"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="117"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="317"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW69728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="463" mass="48990" checksum="6A8BD487F3D77CC5" modified="2011-04-05" version="1">MFVPGHILFAATQRVHFIGIGGIGMSGIAEILVTMGYSVSGSDLRGSAVTERLEKMGATIYIGHAAANAAASDVVVTSSAVSKDNPEVLEARARKIPVIQRAEMLAELMRLKYGIAVAGMHGKTTTTSMIAAVLAGGGLDPTVVVGGRVDALGSNARLGTSQYLVAEADESDRSFLKLSPILAVVTNLDREHTDCYPTMDDVDAAFLQFMDALPFYGATTACIDNERLRGILPRVRRKVYTYGESHDADFRLEMLPGVDGVRSTFEVNYRGLLLGPFELHVPGRHNVLNATAAIAVGVQLGIDPASIAKGLATFRGVDRRFQLKGTVGGIAVVDDYGHHPTEITATLKAARDCGYGRVLVVFQPHRYTRTRDLMPEFAAAFGDADAIQILDIYAASEQPIPGITGEALAQQIAQQTDGRATYAPSVAAAIAALTAQARPGDVIMTLGAGNVSAIAPQLLEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB9</accession>
    <name>E8WXB9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0380"/>
    <dbReference type="EnsemblBacteria" id="ADW67452">
        <property type="protein sequence ID" value="ADW67452"/>
        <property type="gene ID" value="AciX9_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0380"/>
    <dbReference type="HOGENOM" id="CLU_1169353_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233953" evidence="1">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="24653" checksum="2ABC6D94866EA39E" modified="2011-04-05" version="1">MSLLRSFSKYFGMALCAGLLCAGSPALLGQSLKLDDPAPLRAGLNSATIDSFGGNQYWVLTVGPGKFTATFHFGGTQEGFNTGGRPNFFAGFKPKVDGTTLTHADFPGGSTWSGTATKASRLELAVTPAPGSLVRQTTSYTIEVTGAVAFGGAAGASAGPSPVGIYQIGIGGHVGIAKFTADGQITATTNETGTWKVFDEDSKSYVIVFAGTRYSLTYQPGRGFIDNNGYLTFKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI0</accession>
    <name>E8WXI0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1543</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579915.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1543"/>
    <dbReference type="EnsemblBacteria" id="ADW68596">
        <property type="protein sequence ID" value="ADW68596"/>
        <property type="gene ID" value="AciX9_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1543"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2180131_0_0_0"/>
    <dbReference type="OrthoDB" id="2095461at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="12327" checksum="5067DD2217B198C8" modified="2011-04-05" version="1">MGLDTVEIILRTEETFAIDLPDSDCAQVRTVGDLYRLVLEKLSLPYQPATETEAIPTAHNRSRLRTVTPFDFTTPDVWLTLKALIIDQLQVKDSEVHEQATFIHDLGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK6</accession>
    <name>E8WXK6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1569</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1569"/>
    <dbReference type="EnsemblBacteria" id="ADW68622">
        <property type="protein sequence ID" value="ADW68622"/>
        <property type="gene ID" value="AciX9_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1569"/>
    <dbReference type="eggNOG" id="COG4102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032896_3_1_0"/>
    <dbReference type="OMA" id="GWGSHHF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="46890" checksum="AA5B9620F52936FD" modified="2011-04-05" version="1">MANIRQTLMDRSDWGCDMQGRDVARRGLAGGATRRGFMKGGALALIGTSVIPGFLLRSVMAEATTAAASNKRLVVLFQRGAADGLNIVVPYQEKNYYAMRPTIAIQQKDVLDLNGFFGLHPAMAAFKPLYDQGHLAVIHAAGSTDTTRSHFDAQDFMESGTPGVKSTQDGWLNRALLAGPVPAGAPSAFRAVALGTQVPRTLQGKMPAIAVSNLADFSVGGKGPTTSAISNAFQAMYDESSDAVLHGTGQETFEAVKMLKAADPAHYQPAAGVTYPNTPFGNSLKQIAQLMKANLGVEAAFSDIGGWDTHQNQGAATGQLANRLTEFANGIAAFWKDMGDGAENITLVTMSEFGRTAKQNGTGGTDHGHANAMFVLGGTVKGGKVYGKWPGLDNAQLNEGRDLAVTTDFRRVLGEAAYKTLGARKLETVFPGAQLDPSGFLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL6</accession>
    <name>E8WXL6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1579</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579951.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1579"/>
    <dbReference type="EnsemblBacteria" id="ADW68632">
        <property type="protein sequence ID" value="ADW68632"/>
        <property type="gene ID" value="AciX9_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1579"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849657_0_0_0"/>
    <dbReference type="OMA" id="WTDRNKA"/>
    <dbReference type="OrthoDB" id="1936926at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230047" evidence="1">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="35636" checksum="42C441579B277E75" modified="2011-04-05" version="1">MLLKSFLFCAFAMMGAGSGLAQQDMEHMVLKVGGVYYFGYGGVDLSKLRALLPLHAGDNFSYATFDEDEAAAAVTHVTGKPPTDISEVCCDEAKKVTFYVGLAGTTSRTLPSNVPPTGADHVAPEALALYDAEMTALGLAMAAGRNGEDDSQGYTLLNDPASHAINLKMRAYAVGREAEITRVLEHASNVKQRQVAAALLGYVQRSSTQVSALERAILDADGGTRNNAVRALAVLAAAQDATPFEIDPNPLIALLYSGKWTDRNKASALLSRITEKENPALLRALRQQALPVLIEGASWDEGHGIAFVLILGRVLGVTPGSVKEMIAAGTCCGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV1</accession>
    <name>E8WXV1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnA</name>
        <name evidence="4" type="ordered locus">AciX9_2772</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581111.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2772"/>
    <dbReference type="EnsemblBacteria" id="ADW69796">
        <property type="protein sequence ID" value="ADW69796"/>
        <property type="gene ID" value="AciX9_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2772"/>
    <dbReference type="eggNOG" id="COG1427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059898_0_0_0"/>
    <dbReference type="OMA" id="WGLARTG"/>
    <dbReference type="OrthoDB" id="1062841at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="279" mass="30771" checksum="E2F6DFF858A39AE3" modified="2011-04-05" version="1">MALRVAAIDFLNPAPLMWDFDHGPRLSQRYDVHLTEPSQCARELLAGRADLGLIPVAALTPELAIVPGCTIASLRQVRSIQLVVKGTAGLASVRTIAADTASRSSVAYTQVLFRHFLKTDPTYLPAKADPIPMLQSADAALLIGDPALHALEHRTQIEAAVGPCQWFDVATEWNTRTNLPWVAAVWAVRPEALPTAAARTELIEDLNQSRLHGQLHTEDLVTEWQPRIHLPAQTIRHYLTQNIHYTLDPACIEAIELFRHLAAEINALPPLGPLNFLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY01</accession>
    <name>E8WY01_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0468</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578868.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0468"/>
    <dbReference type="EnsemblBacteria" id="ADW67540">
        <property type="protein sequence ID" value="ADW67540"/>
        <property type="gene ID" value="AciX9_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0468"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056917_0_1_0"/>
    <dbReference type="OMA" id="GYLLPKR"/>
    <dbReference type="OrthoDB" id="1559784at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="158"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="33608" checksum="BF422CA84EBAD3FE" modified="2011-04-05" version="1">MTLIFFVSILVLMFSAMGLAGSFLLLRNSRGITERVLQVTQGGTGAIQPKHAVREELKKKVFEAVHVVRARLGMNENAKLSERFQGAGFRTASARDIYFAARLIGPAAAIVFGIIMPQNKVFWMMMVGGILYLAPDIILSRMVKGRREKIRLSIPDMIDLLVICVDAGLGMDQAMLRVGQELGTTHPQIYEEIMQINREQRAGKLRLESWQAMAQRTQLPEIDGFVNMLMQNERFGTPIARALSTFGDNIRQKRRQRAEELAAKTTVKIIFPLVLFIFPSMFIVLLGPAGISIARGLASGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY91</accession>
    <name>E8WY91_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1668</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580037.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1668"/>
    <dbReference type="EnsemblBacteria" id="ADW68718">
        <property type="protein sequence ID" value="ADW68718"/>
        <property type="gene ID" value="AciX9_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1668"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="WKEYGDQ"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="26587" checksum="67797AB6BB461E04" modified="2011-04-05" version="1">MIQLSHLDRTYKAGHSELFVLRNINLTIELGEFVTIMGPSGAGKSTLLNVLAMLDDQWRGEFLFEDAAVHTMNRKQRAELARRRIGMVFQSYHLLEDLTVAENIDLPLSYKDMHRAERQALVADTLDRFSIVGKKDLYPSQLSGGQQQLVGIARAVIHKPALLVADEPTGNLHSAQAAEIMDLFKQLNREGTTVIQVTHSDLNATYGSRTLELRDGWLTRDTAHPDLQRSQNGTQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB8</accession>
    <name>E8WYB8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2801</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2801"/>
    <dbReference type="EnsemblBacteria" id="ADW69824">
        <property type="protein sequence ID" value="ADW69824"/>
        <property type="gene ID" value="AciX9_2801"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2801"/>
    <dbReference type="HOGENOM" id="CLU_3168638_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5614" checksum="EBD15D3BD5E42B9E" modified="2011-04-05" version="1">MERTFAIVSKIRPFRPKPSRPRRRANRILRIASLLNRTPPRCPMSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI2</accession>
    <name>E8WYI2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2865</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581203.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2865"/>
    <dbReference type="EnsemblBacteria" id="ADW69888">
        <property type="protein sequence ID" value="ADW69888"/>
        <property type="gene ID" value="AciX9_2865"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2865"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_0_0"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="314"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="405" mass="43384" checksum="4A897556923CFA13" modified="2011-04-05" version="1">MVLVEEQVQALPKLTNEEVARYSRHLILPEVGYEGQQKLKAAKVLCVGTGGLGAPLALYLAAAGVGTLGLVDFDTVDASNLQRQVIHSTKTVGMLKVDSAEIMLKGLNPNLNVVKYNTMLTSENALEIFKDYDVIADGTDNFQTRYLVNDACVLTGKPNAYGSIFRFEGQASVFATETGPCYRCLYPEPPPPGLVPSCAEGGVLGILPGLVGIIQATEVIKLILGIGETLAGRLLLVDALGMNFRTLKLRKNPDCPACGTHEIKELIDYDQFCGIEKPTSVGPLEVAQNKDVSGAVVDGIPQISVLDLKAKRDAGEDFFLLDVREPHEYPIANLGAPLIPVGSLEARISEIPVAKDAEIVVHCRSGARSQKAAIVLKNAGFINVQNLAGGILDWADKVDTTMAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ7</accession>
    <name>E8WYJ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0523</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578923.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0523"/>
    <dbReference type="EnsemblBacteria" id="ADW67595">
        <property type="protein sequence ID" value="ADW67595"/>
        <property type="gene ID" value="AciX9_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0523"/>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508568_0_0_0"/>
    <dbReference type="OrthoDB" id="196825at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230465" evidence="1">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="19297" checksum="D3A5A1648C0F4FE8" modified="2011-04-05" version="1">MKKPHAILTLAAVAVLNLSVYAATACAQETREQAAAHLRKPETKEMDPTFTTAAPFAQKLVDEALAKHPEVLLLALHAGAPKYDIVASNFGRIGKLGDEDDLRCIHTGKDNLEVNKEGIHFEDQTPLRDQSGKIIGAIGIVFSYKPGDDKMKLQAIAKQIQAEMKADIPSSKRLFGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ9</accession>
    <name>E8WYJ9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0525</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578925.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0525"/>
    <dbReference type="EnsemblBacteria" id="ADW67597">
        <property type="protein sequence ID" value="ADW67597"/>
        <property type="gene ID" value="AciX9_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0525"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="ASHKMEE"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="248"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="466" mass="50567" checksum="456D1B94968F213F" modified="2011-04-05" version="1">MLSPHSLVRQTILVVLGAELLCVLAFSVTALEHERHTRRHAFDAMLKGRSDSVLATIQDAEDPADPLRMDDSEVHPQAGDAYAVYNLDGGLVSSSPNAPSALIQRKADGFSDEIVHGHPYRILQRSAARVLDRSDTNSPVVRRVTILYAANTEHIGHEIREAAAFYFAVSLVGFLLTTLILVVLLRRILHPIQELADKAAAVSVSAPQFEAPASALRLLELRPLAQTLTTAITGLRLALAYERNFVGDAAHELKTAVAVVRSSIQLLMLRSRSREEYARGLEVLLKDNRRVEDLVEQMLLLARMEERGREVELTDLAIPAATVVSTLTNYAEMRGVHLLLDAAGDAFTGMSPEKAEVLLSNLLTNAIQHSPHGSQVEVRCRVEDKTVLLQVEDHGAGISAAALPHVYERFYREDVSRSRETGGTGLGLAVCKSIVDGAGGSISIASTVAVGTTVTLKLRLRQPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM8</accession>
    <name>E8WYM8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">AciX9_0554</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578954.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0554"/>
    <dbReference type="EnsemblBacteria" id="ADW67626">
        <property type="protein sequence ID" value="ADW67626"/>
        <property type="gene ID" value="AciX9_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0554"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086979_1_1_0"/>
    <dbReference type="OMA" id="HEIMHGL"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW67626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="230" mass="25332" checksum="50ABC074A6771F17" modified="2011-04-05" version="1">MSLEVALAVFEYVVMVLALSFHDMVQAWTASRLGDQTARMLGRITMNPVKHYDLLGTIIFPVIFIYQSPLVLGWGKPVPMTTRNFGKRGEMLVYASGPAAHLFAAGVCLIALLVLKHTVPAIALALPVAAALSLRDTSVATVGLPQAFPVVLFLYYGILVNLLLFAFNLVPLPSLDGGKVLRYFLPYNAKEQFDRMGFWLMIAFFFVGFRIILAIMSPLMGLFNGLLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN8</accession>
    <name>E8WYN8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0565</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0565"/>
    <dbReference type="EnsemblBacteria" id="ADW67636">
        <property type="protein sequence ID" value="ADW67636"/>
        <property type="gene ID" value="AciX9_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0565"/>
    <dbReference type="HOGENOM" id="CLU_2806438_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7460" checksum="CDCE342BA7C36645" modified="2011-04-05" version="1">MKLIYMVDGNVFNAEALISIEARGEDDTVITLQGGKELVYRMQPHTMGIEITKAMNSLNHFVVGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT1</accession>
    <name>E8WYT1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="13">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">secA</name>
        <name evidence="18" type="ordered locus">AciX9_1719</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="13">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580086.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1719"/>
    <dbReference type="EnsemblBacteria" id="ADW68767">
        <property type="protein sequence ID" value="ADW68767"/>
        <property type="gene ID" value="AciX9_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1719"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_0"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="11 13 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="17">
        <location>
            <begin position="3"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="107"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="896"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="938"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADW68767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="997" mass="111813" checksum="26FF897846C0AA9D" modified="2011-04-05" version="1">MINAVIAKVFGTANDRALKRILPIVQQVNSHEAALQSLTDEQLRDKTAEFRQRVAAAIEGIDPREDADALYAAEKAALDALLPEAFAVVREAGKRVVGMRHFDVQLIGGTILHQGKIAEMKTGEGKTLVATLPTYLNALASRGVHVVTVNDYLAKRDAEWMGKIYGFLGLTVGVIVHDLSDEQRRAAYASDITYGTNNEFGFDYLRDNMKFELSDMVQRGQYYCVVDEVDSILIDEARTPLIISGPTDQTTDKYVRVNVIIPELVLGELTETVDSKVYTGDFVIDEKARATTVTDEGWEKIEKLLEIGNIADPENWDLKHHVEVAIKAHHLYKRDVEYVVKDGEVIIVDEFTGRLMPGRRWSDGLHQSVEAKEGVNIRKEDQTLATITFQNYFRMYKKLSGMTGTAETEAAEFDKIYKLDIVVTPTNRQMLRIENPDVVFRTTKEKYFAVADEISRLHDLRQPVLVGTTSIEKSELLSDILKKKGVRHVVLNAKFHEKEAEIVAQAGRLGMVTIATNMAGRGTDILLGGNSDFMARQDLVRKQQARAVSAAEGAIQPVAGPGMFRFYYNNQEFECSQEAWDGAVASHEAAAKAEHQEVLAAGGLHILGTERHESRRVDNQLRGRAGRQGDPGASRFYLSLEDDLMRIFAREWVSSLLERLGMEEGVPIESGMISRRIEAAQKAVETQNFESRKHVLEYDDVMNKQREAVYGLRKQLMEGVDQKQLITEDYTSTIMSNILDETAPEKAHPDEWKSEALFDQIYDIFGARFTNGTDTPTALDLTTLSRHELGESIFDRLRARYDIKEQILGATAMRYHERIVMLSVLDGLWKDHLLAMDHLKEGIGLRGYAQQDPLVAYKKESFDMFEAMMMRFQEDTARHLFRMQIIGPDGQPIESAEQLAAAQAAQQQPPTIEGQLPELEAPRPTIPTKAPATTIDALEREFQKRKERELEQSRQASASATADESNTQRIAGERVGRNDKCPCGSGKKFKNCHGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU8</accession>
    <name>E8WYU8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1736</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580103.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1736"/>
    <dbReference type="EnsemblBacteria" id="ADW68784">
        <property type="protein sequence ID" value="ADW68784"/>
        <property type="gene ID" value="AciX9_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1736"/>
    <dbReference type="HOGENOM" id="CLU_1494217_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="18437" checksum="E359E25A251FFC7E" modified="2011-04-05" version="1">MRIAQASKVMQHEEFRKDVAQALSAGEEIHVESPAALIAANPFSQSPLLISQIALGASLLSGIQVTDANREFLQRALLGTGPVPTAPITTDKRKLFNFTATGALSGTIIGAAVGVLLEQVRAVHPTSAVAFDATLAVLGCTVGATMGAGATQGSPSVSITPAFSHTGEVSCKIAVEYKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV1</accession>
    <name>E8WYV1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1739</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580106.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1739"/>
    <dbReference type="EnsemblBacteria" id="ADW68787">
        <property type="protein sequence ID" value="ADW68787"/>
        <property type="gene ID" value="AciX9_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1739"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_0"/>
    <dbReference type="OMA" id="CVATTHW"/>
    <dbReference type="OrthoDB" id="871215at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="211"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="34022" checksum="94222A3D3758C57F" modified="2011-04-05" version="1">MRRVVITGPPPVQILDVTGPLEVFSNAPGYDIQLVAPDGGNILRTNRGVDLGSAIPLAQCTGPIDTLIIAGGPGAESGVYDPILTQWIAAAATRSRRVASICTGAFMLAEAGLLDGKNAVTHWLFCDSLAQQYPAVKVQRDPIYLRDGSIYTSAGITAGIDLSLALVEEDHGHHEALRIARFLVMFLVRPGGQAQYSHMLSHQAAASQPLRELQVWMLEHLRDHLSVESLAERLGVSPRHFTRVCLRETGLNPGQLIDRMRVEAAQQIIDSSAKGLKEVADACGFHSAEAMRRAFTRILGVTAADYASRFRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY7</accession>
    <name>E8WYY7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2879</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581217.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2879"/>
    <dbReference type="EnsemblBacteria" id="ADW69902">
        <property type="protein sequence ID" value="ADW69902"/>
        <property type="gene ID" value="AciX9_2879"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2879"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005503_0_0_0"/>
    <dbReference type="OMA" id="YVHIPGM"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230084" description="Tricorn protease homolog" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="792"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="771"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119149" checksum="74F9BB75800BF914" modified="2011-04-05" version="1">MPFRPTRALILALLCTPLYAQRPSLSDPTISPDGHEIAFVSGGDIWSVPAAGGEAHLLVTHPATESRPLYSPDGKKLAFISTRTGNGNIYILTLASGQLQRLTYSDVPDRLDAWSKDGQWIYFTSAIDDVAGQGDIFRVRTTGGTPLEVTHERYMNEFESSPSPDGSQIAFMAKGISASQWWRNGHAHIDETELWLKPVGDSAPYKKLLPADSKHAWPMWSADGKSLFYMSDASGAENIWETPAGSASPKALTHFKEGRVLWPSIGDSGHTIVFERNFAIWRMDTASGKAEPVRIELRGSAGTPGITRVTETSFRTLALSPDGKKVVVLAHGQLFAASAKDGGDGQRVKSEAVSMSDPQWSPDSTSVAYIAERMDGSHQLELFSFDTLKARPLTIIPGESQAPSWSPNGKLLAYVHDNKDLHVITMPDPKAKAPSTVPLPDKIITSGALAQPSLAWSPDNQWVAFTSVDARSFRNLNVIQAAGGEPHPITFLGNGETAYSRIAWSPDGKYILFETAQRSENIQIARVDLLPHVPRFREDEFRDLFRTTRPPGTPATPATPTTPAETPASEPKADATDTPDKPKPAAPEKKQPEPVKIVFEGIRRRLTILPLGLSAERPVISPDGKVLLFSAETARQESLYTYSLDELAREPAVARQLTSTPGSKGAYAFSPDSKEVFFLENGTVKTIALESRTPKTVAISGRLQIDFDQEKKVVFEEAWGTLNRRFYDGKFNGQDWRKLHDEWQPYIDGAQTGDELRRDINLLIGELNSSHSGINRPMPGPGGAEPRTTQVGNLGLRFDREKYEAGQGLIVREVIQLGPAFIEGSIKPGDKLISINGDAIEGYDLDQLLEDTVNHRTVLSVETAGKSREVIVRPIPSAAAVGLVYRQWVEERRAYVDRISGGKIGYVHLAAMGDGDLQQLYLDIDAQNESKQGVIVDVRNNNGGYINGYALDVFTRKNYLEMTPRNMGTVPSRQDLGQRALGLPTILVTNESTLSDGEDFTEGYRSLQLGKVVGEPTAGWIIFTGAQQLIDGSSVRLPFTRVQDLRGQTMEMHPRPVDIEVDREEGETSAGTDGQLDRAVKELLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ24</accession>
    <name>E8WZ24_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ordered locus">AciX9_2916</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581254.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2916"/>
    <dbReference type="EnsemblBacteria" id="ADW69939">
        <property type="protein sequence ID" value="ADW69939"/>
        <property type="gene ID" value="AciX9_2916"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2916"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_1_1_0"/>
    <dbReference type="OMA" id="GVTHEDC"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22263" checksum="B32D7BAB16BBE49F" modified="2011-04-05" version="1">MPLQIDTIRATAERVAASHHLEVVDVEFSGGAKFRSLRVFIEKDAESRAKLAAQLTAAQEASDSVEVGFELPVLPSGVPVESLSGVTHEDCADFARDFGTVLDVEDTIPGAEYTLEVSSPGLERKLAKPADFARFSGFLIKLQTFTAVDGNRHFQGRLTGFNPEAQTIALDPSAVKQKGKSKKSAAAPQPVEIAFQNVEKANLIPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ54</accession>
    <name>E8WZ54_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0585</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0585"/>
    <dbReference type="EnsemblBacteria" id="ADW67656">
        <property type="protein sequence ID" value="ADW67656"/>
        <property type="gene ID" value="AciX9_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0585"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051162_0_0_0"/>
    <dbReference type="OMA" id="MASLPWI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="437" mass="46000" checksum="B41BD2648D787732" modified="2011-04-05" version="1">MRAHLSNSMYGMLDYIAQPAAMLLAAPMLLHHLGVARYGVWLIASAAVGAGTVVSSGFGDAVIQRVATLRATDDLAGIRRVVANMLALNLALGGALALTLWAVVPFAAVRITHVEPRLYHDCVWALRIGAALIVVKAVESVFISSQRAFERYAPAVKIGIAMRLIAVGLAASLGAEGYGVAVLMIGTLVLTCLGVAAQACALRRHLGPGLTWPAFDRTVSRQLTSFGGFSWLQAVSGVIFSQADRLLLGTTLGASAVAYYGICVQVAQPIHGLTSAGLHFLFPHLASRSALETHTELGRPIAKAFLLNLAGAGVLLALVLAVGPWAIKSWIGPVFVTDSATLLPEIALSFGLLALNITAHYTLMAFGRVRIVTAANMVGGGLMLVAMTLLIPHRGVQGAALARLWYGPVTCLMYLPLLYLLRRPAARTLVVMGGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA1</accession>
    <name>E8WZA1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0632</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67703">
        <property type="protein sequence ID" value="ADW67703"/>
        <property type="gene ID" value="AciX9_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0632"/>
    <dbReference type="HOGENOM" id="CLU_3234227_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="43" mass="4963" checksum="2DC6DABB055FE26E" modified="2011-04-05" version="1">MTERENFDSAMKKILSVSKEELQKRIEAEKKTNASKPRPRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB7</accession>
    <name>E8WZB7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpB</name>
        <name evidence="13" type="ordered locus">AciX9_0648</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579047.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0648"/>
    <dbReference type="EnsemblBacteria" id="ADW67719">
        <property type="protein sequence ID" value="ADW67719"/>
        <property type="gene ID" value="AciX9_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0648"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_0"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="888" mass="97635" checksum="14206C9BC485636A" modified="2011-04-05" version="1">MAIRWDRLTVKSQEAVQAASGFAAENGNPEVLPVHLMAALLEDREGVVIPVLEKIGVPVEQMLSGVNAAIAKLPKVQGGTQPGLSNGMQKVIEQAFKEAENFKDEYCSTEHLLLALSASGAGSDTVRSALAAFGATHEAILKALSGVRGNTRVTDQTPEGKFQALEKYAKDLTELARRGKLDPVIGRDEEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVSGDVPESLKDKRVVALDLASMVAGAKFRGEFEERLKAVLKEIEDADGEIILFIDELHTLVGAGAAEGAMDASNMLKPALARGGLRAIGATTLNEYRKYIEKDAALERRFQVVYVGEPNVEDTVAILRGLKERYESHHKIRIKDSAIVAAATLSHRYISDRFLPDKAIDLVDEAAAALAIQIGSVPVEIDQLERRGTSLEIEKQALKRETDAASRERMEIVERELAEVQETASGLRARWQTERGAIGKVAELKGRLESLRFQAEEETRRGNLQRAAELQYGEIPQLERELKGLTEAQDELARVDSSHVSDARHGAPRASRMLKEEVDEEDIAAIVSRWTGIPVSKMLEGEVQKLVEMEARLRERVVGQDEALSAVANAIRRSRAGLSDPKRPIGSFIFLGPTGVGKTETARALAEFLFDDEAAMVRIDMSEYMEKHAVSRLIGAPPGYVGYDEGGQLTEAVRRRPYGVVLFDEIEKAHPDVFNVLLQVLDDGRLTDSKGRTVDFKNTVLIMTSNIGAGQLSTAWAENEEGFEDAKVRVIDSLKQHFRPEFLNRVDDIVVFHPLGEEQLAHIIDLRLAELTQMLADRKIVIELTDEARAAIFKAGYDRAYGARPLKRAIQRMVQDKLAIKILDGSVLHGDRVVVDAGRDGLTFSVSERVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ1</accession>
    <name>E8WZJ1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ordered locus">AciX9_2942</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581280.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2942"/>
    <dbReference type="EnsemblBacteria" id="ADW69965">
        <property type="protein sequence ID" value="ADW69965"/>
        <property type="gene ID" value="AciX9_2942"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2942"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_0"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6969" checksum="6F9EBDD9DF6E26A1" modified="2011-04-05" version="1">MATTAKRVKDAKTPKFKSRQHNRCQLCGRPRAFLRKFGCCRLCFRSLALKGEIPGVVKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM9</accession>
    <name>E8WZM9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2980</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581317.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2980"/>
    <dbReference type="EnsemblBacteria" id="ADW70003">
        <property type="protein sequence ID" value="ADW70003"/>
        <property type="gene ID" value="AciX9_2980"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2980"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="OMA" id="PTVKMMR"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="76"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="45339" checksum="BAEEECC750A1A7B3" modified="2011-04-05" version="1">MPKIAYLESVRSHNRISADTPQTLDPATAESLYVRYDMEEMKKTAKRENPAKYAAESAKSLGMWRYKDVLPDVTPVTLGEGWTPMVQSKRHAGLFIKEEGNNPTGSFKARGLAMAVTMAKHYGLQHLAVPSAGNAAGALAAYAAAAGIAAHLYMPQDVPFANYLEGVIYGADVHMIDGLISDCARLVGEEIKRQKEAGTPANEVWFDISTLKEPFRIEGKKTMGYELVEQLGWKYPDAVFYPTGGGVGLIGMWKAFDEMEELGWVERGSKRPKMYALQASGCSPIVKAYDGGKDVSEFFQHAATFAAGLRVPKPYGDAIILDIVRVSGGSAIASTDEEILASILDYAKHEGLFLSPEGAAATAAYERLLASGELTPEETVVLFNTGAGLKYTDMTAEAMKLRRPGTLPTAMPVGGIITPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C6</accession>
    <name>E8X0C6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3087</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581421.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3087"/>
    <dbReference type="EnsemblBacteria" id="ADW70107">
        <property type="protein sequence ID" value="ADW70107"/>
        <property type="gene ID" value="AciX9_3087"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3087"/>
    <dbReference type="eggNOG" id="ENOG5033DWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2117563_0_0_0"/>
    <dbReference type="OMA" id="EYRNALC"/>
    <dbReference type="OrthoDB" id="1739807at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="12451" checksum="108465F19F4F76AA" modified="2011-04-05" version="1">MDISAIVGTELKSVAFVEDFLELRFGTPCLTLYDWPHVLLPDFSVAYGEPEYRNALCAQINEEVVEASLEEGDSLTIELANGVVFGLSLREEDVDGPESGSFSETGQAVDAQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E1</accession>
    <name>E8X0E1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ordered locus">AciX9_0735</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579131.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0735"/>
    <dbReference type="EnsemblBacteria" id="ADW67805">
        <property type="protein sequence ID" value="ADW67805"/>
        <property type="gene ID" value="AciX9_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0735"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_0"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="243"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="484" mass="52602" checksum="9B3DC2AA498C0E8B" modified="2011-04-05" version="1">MATATVDVQAVKSAANDYKVADISLAGFGRKEIDIAEQEMPGLMSIRRKYAAGKPLQGVRVTGSLHMTIQTAVLIETMVDLGADVRWASCNIFSTQDHAAAAIAAAGVPVFAWKGESLEEFWWCTNEALSFPDGKGGLLGPQLVIDDGGDVTLLIHKGYEMEAGDKWVDSPSGSQEEGVIKDLMKKVHAQFPTRWTDCAKEWRGVSEETTTGVHRLYKMKEKGTLLVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMVAGKVAVVCGFGDVGKGSAASLRGLGARVIVTEIDPINALQAAIEGYEVTTLEETLGRGDIYVTCTGNVDIITLEHMKLMKDQAIVCNIGHFDNEIQMEPLNASGATKLNIKPQVDKYTFASGNSIFILAEGRLVNLGCATGHPSFVMSASFSNQTLAQLDLWENKDKYAKDIYILPKKLDEEVARLHLEKIGVKLTTLSPKQADYLGVPVDGPYKAEIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S3</accession>
    <name>E8X0S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580343.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1978"/>
    <dbReference type="EnsemblBacteria" id="ADW69024">
        <property type="protein sequence ID" value="ADW69024"/>
        <property type="gene ID" value="AciX9_1978"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1978"/>
    <dbReference type="HOGENOM" id="CLU_1501468_0_0_0"/>
    <dbReference type="OMA" id="KWFITIC"/>
    <dbReference type="OrthoDB" id="2186040at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="20159" checksum="86881F483DC3D432" modified="2011-04-05" version="1">MSPINKPTTIKELDGLPAGEIDFRIAQSEQRTKQFLEARLNTQDEKLDTMQQDLSALVGTPLVAGMIKDIKTSIDAVRDRQEEQAGKHSDWHEADLTFRTEVITRVGTIETEQKKMTGQMRMIRWFVATSKGVSKCLELAIKALTEADFWKVFGAAGLMWALSHYAPAVFKVVAEYVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V9</accession>
    <name>E8X0V9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malic protein NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3129</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581457.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3129"/>
    <dbReference type="EnsemblBacteria" id="ADW70143">
        <property type="protein sequence ID" value="ADW70143"/>
        <property type="gene ID" value="AciX9_3129"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3129"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_0_0"/>
    <dbReference type="OMA" id="QMWDPVY"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="260"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="539" mass="59054" checksum="4DB5CBAD85AD394D" modified="2011-04-05" version="1">MNSLTGIALLEDPKENRGTAFNQAEREEKGLVGLLPPVVETLENQVKRCLYQLSKKNNDLEQYIYLAQLADDNQTLFFAVLATDPARFLKIVYDPTVGTACLEFGHIYRKPNGMYLSMDQRGKLKEVLKNWPVGDVRVICVSTGGRILGLGDLGTNGMGIPIGKLQLYTACAAVQPDVLLPVLLDCGTDNEKLLNDPLYLGLKQKRPTTDELDAFVQEFVDAVQERFPKCCIHFEDWKGTDALRLLARYVTEISCYNDDIQGTGSVTVAGLYNAMKISKGDLKDQRVLFFGAGSAGIGIANMIASAMKLEGLSEREARERISLFDVNGLLEPSRKDLSPDQLPYAHPAQPTKDLVAAINELKPTILIGVSTVGGTFTQQVIEAMSKLNERPVIFALSNPTEHAECTAEDAYKFSKGKAIYAAGVQFDPVTIDGKTYEPSQANNFYIFPAVGMAIVATEAEHVPDEIFIAAAKATADQVTDEQLAKGILFPEQADVQKVSHVTAVKSAEKIFELGLARIDKPESVDTLVTSLEYKPIYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W8</accession>
    <name>E8X0W8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581465.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3140"/>
    <dbReference type="EnsemblBacteria" id="ADW70152">
        <property type="protein sequence ID" value="ADW70152"/>
        <property type="gene ID" value="AciX9_3140"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3140"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_2_0"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="20663" checksum="A6C91F37BC015A33" modified="2011-04-05" version="1">MTALEDTLRAFERAATLDSTVAYMGSLMTFLAKASETDGRFALMEYYTKPGNEPPPHIHDREHEMYFVLEGSMRFYCEDKTMDINAGDVVFLPQGKAHAFNCLSPQVRTLILVAASGEGSVGLDSYFLTMGEEPQSMSLPDHALTYVEETPERAIKACNDNGIYVMSEDETRKALPQYPGFGAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X107</accession>
    <name>E8X107_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0805</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0805"/>
    <dbReference type="EnsemblBacteria" id="ADW67873">
        <property type="protein sequence ID" value="ADW67873"/>
        <property type="gene ID" value="AciX9_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0805"/>
    <dbReference type="HOGENOM" id="CLU_3136213_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="5656" checksum="D7D6BDEE8DCB2A5B" modified="2011-04-05" version="1">MNKPDMSVEQKKRMPWVEPEIRQLDVRETASNEGFGGDGQKRFADCTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X170</accession>
    <name>E8X170_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0868</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0868"/>
    <dbReference type="EnsemblBacteria" id="ADW67936">
        <property type="protein sequence ID" value="ADW67936"/>
        <property type="gene ID" value="AciX9_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0868"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="390"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="530"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="790" mass="86287" checksum="5E1D693D00CB87C1" modified="2011-04-05" version="1">MRAGEEGFVGGSPGMGGAAARMLLTLRAGGAVKRQRRLLSRRELTWVSVLVGLAVLAQVVHTFDLLFVPRPLWISNGMQVLLPVLALTICLVRRGESGEEVRRSLWTKLAAAFVFWTVAELLYLAELYVIPKTANLNWPDDVLWLLFALPILMVTSGAGSFRKGDARNWVSGLDHGQAFLFFFILLSSVFFAPHTLPFTTAYNVQNLTLVLSCVLRLSSAETMTELGFYGGLGVYLLVYAVCAGVGNALQARGMGPGSMVDIFWSLPITIFCVLAGMRLSGAERSVRRLRPWARSVARLMQGVSALGLAIVSVGAAAAVMGRHPVLGYMSLVGGFGLFALRTVVRELQSFKANDQLRDAVLRDHLTGLGNRALFREHVGSFVTKLVRPEMKVALMFVDLDRFKAVNDELGHGVGDRLLIETAGRLERASRKEDLVCRLGGDEFVVAMVIAGEAMARNRAEDLLDAIREPFAVDGRVLKMTASIGVVLGDATDDVESLLRKADGAMYSAKKLGKDQAQVFDVAFIERMNQNWMLEQELQRYLEEDAIQVAFQPIYSVTAKRIVGVEALARWSHAVRGNISPGVFIPIAEEAGLIGALGAQVMRRGCREVAAWNEAWGVSLFLSVNVSAKQFADAGLLAAIHSMAGECGLGAELIHLEITESVLLMDDVAVERTLMEARGYGMGISLDDFGTGYSSLSYLLNLPVDEIKIDRSFINDLHLDPRRVELVRAVLTLGQTLGKRVVAEGVEREDQLEILHGLGCEFVQGYLISRPLESEAMNDLLGMVGKARRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B2</accession>
    <name>E8X1B2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2021"/>
    <dbReference type="EnsemblBacteria" id="ADW69066">
        <property type="protein sequence ID" value="ADW69066"/>
        <property type="gene ID" value="AciX9_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2021"/>
    <dbReference type="HOGENOM" id="CLU_1545461_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="18862" checksum="4AC7891C346599B4" modified="2011-04-05" version="1">MSYLFINTTAVLDSTNTAFFTSLSGRTCTPPLKMGIEEKSSLLRGFLAATIQGLSHLRDTFGNGNGYSIDVCIPNEAIAREIREHSSRKSLLHGDDDALWADFHRLSTGFELKFISSPGESGNLRTFYGWNSTPFILGELEGEVGYTPAKLTPAAAPEPPPIRYAPNYKVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I0</accession>
    <name>E8X1I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3204</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3204"/>
    <dbReference type="EnsemblBacteria" id="ADW70215">
        <property type="protein sequence ID" value="ADW70215"/>
        <property type="gene ID" value="AciX9_3204"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3204"/>
    <dbReference type="eggNOG" id="ENOG5034BKX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1784139_0_0_0"/>
    <dbReference type="OMA" id="RTHRIVR"/>
    <dbReference type="OrthoDB" id="1957082at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="15929" checksum="82654ACD6E7D03FC" modified="2011-04-05" version="1">MSVRQNFPQGLANSRTEELKRRVGLPVEEGFAQSASASGAHAAASAAMVNRTHRIVRERARTIQARRSRVRSLWLPLAVCSGLLVVICAAIWSVLDEYELVPTGMPDASQQMFVLLMWCLPLSAVLIALVWFRRAGTRIEGGGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X1</accession>
    <name>E8X1X1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2088</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580448.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2088"/>
    <dbReference type="EnsemblBacteria" id="ADW69132">
        <property type="protein sequence ID" value="ADW69132"/>
        <property type="gene ID" value="AciX9_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2088"/>
    <dbReference type="HOGENOM" id="CLU_1737989_0_0_0"/>
    <dbReference type="OMA" id="VHNCTAC"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230573" evidence="2">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16115" checksum="34A208B6F8ED30CD" modified="2011-04-05" version="1">MSRKLTLILGAAACTLLCGLCISSQALAQKLQLPDDTGKPEFVHNCTACHLASLVVAVKKTPDDWRKNVDDMAARGTDGTKEDLDKVVVYLDKYYSLQTPAPSEAPHPAPQSTLHAPTTLSPTDRERLKQILAEPGTAQVTASNSKPHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X232</accession>
    <name>E8X232_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain-containing protein DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3264</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3264"/>
    <dbReference type="EnsemblBacteria" id="ADW70275">
        <property type="protein sequence ID" value="ADW70275"/>
        <property type="gene ID" value="AciX9_3264"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3264"/>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155311_6_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7807" checksum="766788A4D7F1D739" modified="2011-04-05" version="1">MPAIQISDELDANLDQLVRQTGGSKEAYVSEAVRNLLEDAEDLALAKERISRPGRRFTLDEVERHLGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X238</accession>
    <name>E8X238_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581593.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3270"/>
    <dbReference type="EnsemblBacteria" id="ADW70281">
        <property type="protein sequence ID" value="ADW70281"/>
        <property type="gene ID" value="AciX9_3270"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3270"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_1_0"/>
    <dbReference type="OMA" id="DQYSFVR"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234098" evidence="1">
        <location>
            <begin position="23"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="310"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="554" mass="59801" checksum="D6B4C55C997B66BA" modified="2011-04-05" version="1">MNVSRLLKAAAAAAFFASTLFAQSTDAERGQQWWHHVQVLADDSMKGRLTGSDDYLRAAAYVVEQFKSYGLQPAGLSVNGKAGFYQPVHFDVQRVIAAKSSLALVEKGTTTPLTLGQDAILGTRSPQPKTITAPLVFIGYGLHLPESHYDDFDSSELPMSGLKGKIVVYLNGGPGDLPTALKSFARTSPFAKALRDAGAVGTISIPTPKSMDFGWERVASSASQPGMRLAEDPQAAKVAALHPALADEHGQMFSATFNPAQAEKLFAGTGYTFADLLALADAQKPLPRFALNKSITATVATEVTQVVSPNIVAKLAGSDPKLAADYVLVSAHLDHLGVGEPIHGKTIYTGAMDDASGVASVLEVARSFAANPTRPKRSMLFVIFTAEEKGLLGSRYFAGHPTVPEQDITADFNLDMFMPIFALKKLHVQGLEQSTLQEQAKTVGAAHNIQIAVDPEPDRNSFIRTDQYSFVQAGVPALAFKFGWTAGSPEYKAWRAWLAQRYHSTDDDLKQPVDYAAAAQFNAYLADLARTVANDPTTPHYLDTSFFKRFENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X256</accession>
    <name>E8X256_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3288</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581611.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70299">
        <property type="protein sequence ID" value="ADW70299"/>
        <property type="gene ID" value="AciX9_3288"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3288"/>
    <dbReference type="HOGENOM" id="CLU_1439232_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230175" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="20319" checksum="897BCD92B75088ED" modified="2011-04-05" version="1">MAQSFKTLALLALALCFGQAAEAQAKSPVLSADDTVAFINTTLHKYPTLEFVKSGCPGDEQTVSISDDRRSIIIRQTSVMPVDGGSCDTVQTLTAPIFSLHLIGIGSWTKQGQHTSFFMDCTERVGCFSRRSGPPTPPAIESQWRLAITAPDEVSSRLQKAIRHLVEALLVEADDHIDANDPTAKPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V7</accession>
    <name>E8X2V7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1028</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579414.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1028"/>
    <dbReference type="EnsemblBacteria" id="ADW68091">
        <property type="protein sequence ID" value="ADW68091"/>
        <property type="gene ID" value="AciX9_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1028"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="YHQEERS"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="21075" checksum="A7C0253CF155FD5F" modified="2011-04-05" version="1">MPSEPSFEQIVQDHQAMVFRTLVRLTGRTNDIEDLAQDVFLRLFRALPSFRGDALVTTYLYRITVNVAQDEWKRRRREDRRHVSISDDTEGWDDRLADPNPNAMEQLEETQFADLVNEQLNQLSLIEHTILVLYHQEERSYDQIATVLGMPIGTVRTHLHRGRKKIRSGLQTSTAKMKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W4</accession>
    <name>E8X2W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1035</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1035"/>
    <dbReference type="EnsemblBacteria" id="ADW68098">
        <property type="protein sequence ID" value="ADW68098"/>
        <property type="gene ID" value="AciX9_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1035"/>
    <dbReference type="eggNOG" id="ENOG5033G8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1388522_0_0_0"/>
    <dbReference type="OMA" id="PMEPRTW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="196" mass="20595" checksum="48045C9B853864A6" modified="2011-04-05" version="1">MIALVTASLLPMEPRTWESLVHQTNMVKLYGIRIAFFCGLALLPIAAVHAQDAASPAACTLAKETYHCDRGAFRQALSAAKVIGVESVPVSRMVSGQLTELVAKIGKTVAGEGAAADLTFSLLKRDLGGVIIGPSGAELATLRVYGPAHGGERGDLIWAEIYTGQPDMQWPAVAHSLIEQFRGSAGLAGKASGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y9</accession>
    <name>E8X2Y9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1060</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579446.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1060"/>
    <dbReference type="EnsemblBacteria" id="ADW68123">
        <property type="protein sequence ID" value="ADW68123"/>
        <property type="gene ID" value="AciX9_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1060"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_0_0"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="282" mass="29723" checksum="85145076424A4630" modified="2011-04-05" version="1">MTSLPDLYTRAQSAAAYIRTLTPLVPAVGIILGSGLGSFASAVENPVTIPYATIPHFPQSTVEGHSGNLILGTIAGVPVAVMQGRVHAYEGYTMPEVTFPTRVLGLLGCKTLIVTNAAGGIKPTYKPGSLVAISDHINLTGTNAALGPNEPRFATNETSGYRFFDMTTAYPAALRAIAVEEAAKQGYILEEGVYLAVLGPSYETAAEIRAFRTLGADLVGMSTVHEVIIARHMGIPVLGLSLVTNPAAGVSNEVIHHEEVMDIGRQVESRFSALLTAIIPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X314</accession>
    <name>E8X314_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1085</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579471.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1085"/>
    <dbReference type="EnsemblBacteria" id="ADW68148">
        <property type="protein sequence ID" value="ADW68148"/>
        <property type="gene ID" value="AciX9_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1085"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_46_0_0"/>
    <dbReference type="OMA" id="APREWMQ"/>
    <dbReference type="OrthoDB" id="1309950at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="22796" checksum="7AADEFAFB4271F50" modified="2011-04-05" version="1">MPRTPDTIFEPRKSPVQARSAASVDAILQATIQVLLSLGKDRLTTTRVAQRAGVSVGTLYQYFPNKSSLLQAALRNHLEDVTSSVEQASLQQRGQPLAQQISALITAFLAAKMRHPKTSVALYAVSSDLDAAKIVRQIGDRSNKAIVAMLESSSDRLTSDPQLVALMLQGAMNGVSRRLLETPSPEKRIDALRAELIFFATSYLKACSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X357</accession>
    <name>E8X357_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="11" type="ordered locus">AciX9_2240</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2240"/>
    <dbReference type="EnsemblBacteria" id="ADW69281">
        <property type="protein sequence ID" value="ADW69281"/>
        <property type="gene ID" value="AciX9_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2240"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_0"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="659"/>
            <end position="666"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="902" mass="97804" checksum="30D4970A26711335" modified="2011-04-05" version="1">MAIDTTNDAQLTPVMRQYFAAKEAHPDCLMFCRIGDFYELFYEDAILVSRELQLTLTARDKEKKQPMCGVPYHAAEVYLQRLLRKGYRIALCEQMEDPKTVKGIVKREVTRVLTPGTAVDPALGAGESCWLASVVMVKGVAGVAMVDLSTGEFRATEFVGAGAWALAVDELGRVKPAELVYASGGLLGASGSNRSLKLGADPTQVPEAGPGAPSSVDDSDGAGLDGIKTKSAVEDWVMTAEHALPLLRSHFRVLSLDGLGLGGHEAAGVAAGGLLHYLRQQKQGALEHVEAVRFYERSGCLELDAVSVRNLELVEPLFSGESAQTTLLYTLDACCTPMGKRLLRATLLRPAMGLGEIEVRLDAVGEAAADLRRREGVRRAMNGLLDLERLLGRVAMDSAGPREVLALASTLGCVPRVVAAVGMFTAAKWMELGAGLDPLEDLHEVITATIVDEPPVTFADGGVIRAGIHAELDELRELSRSGRQALVAIEERERARTGIGSLKVRFNSVFGYYLEVTKANAKAVPADYERKQTLVNAERFTTPELKEYEAKILTAQERSLEIERRLFSELRAQLLAAAGRMRETARKVAEIDLMSCFAHLAALRGWVRPVVEEGCALEFVQGRHPVVERRMEESGAGRFVPNSLYLDADAGPSLLLMTGPNMGGKSTYLRMAALLVVMAQCGCFVPAERMRVGLVDRIYTRIGASDNVARGRSTFMVEMTETAAILNTATNKSLVLLDEMGRGTATYDGLSLAWATVEHLHNKIGARALFATHYHELTLLADRLTKLKNVRVTVKENAGGIVFLHSVEAGAASKSYGIEVARLAGLPNGVIARAREVLKVHERAESQQVREAVAEPAGKVQMTLFTPLSQRIVDRLGAVEVDSLTPLEALNLLAELKREMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X381</accession>
    <name>E8X381_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnE</name>
        <name evidence="8" type="ordered locus">AciX9_2267</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580621.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2267"/>
    <dbReference type="EnsemblBacteria" id="ADW69305">
        <property type="protein sequence ID" value="ADW69305"/>
        <property type="gene ID" value="AciX9_2267"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2267"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_0_0_0"/>
    <dbReference type="OMA" id="HIKAYWA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="71"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="43402" checksum="1A75A24E344157AC" modified="2011-04-05" version="1">MSAAPIFTSTALKPRHSFQTDDRNLLPIAEKVQAGERLSFEDGVTLFRSGDILAVGWLANLVRERLHGDLTYFNVNRHINPTNVCVASCRLCAFGRKKGEADTYTMALEEAFETAASGYTEAVTEFHIVGGLHPDLPFEYFMDLVRGLKQRFPKVHIKAFTMVEIAFLAKRGKMTIPEALQQMKDAGVDSMPGGGAEIFADRIRHIICDHKIDGGEWLDTARLAHQMGFRSNATMLYGHVEADEDRVDHMMRLRAVQDETGGFQTFIPLSFHPDHTALSHIPKSTGMLDLRQIAVGRLMLDNFPHIKSYWQMVTPQMAQISLRFGADDVDGTVIEEKIYHDAGATTPQGMRRADLVRLITEAGRIPFERDTLYRAITRTEDTFTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A6</accession>
    <name>E8X3A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581719.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3401"/>
    <dbReference type="EnsemblBacteria" id="ADW70407">
        <property type="protein sequence ID" value="ADW70407"/>
        <property type="gene ID" value="AciX9_3401"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3401"/>
    <dbReference type="eggNOG" id="COG3739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070515_1_0_0"/>
    <dbReference type="OMA" id="WQYPNQR"/>
    <dbReference type="OrthoDB" id="1328358at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008535">
        <property type="entry name" value="DUF817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05675">
        <property type="entry name" value="DUF817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009141">
        <property type="entry name" value="UCP009141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="33740" checksum="BE9ACF862881C298" modified="2011-04-05" version="1">MPGPSNSQLTRFHAFRLRLERHKPSSRFTAFLWEFGLFVFKQAWSCLFGGLLLALVLGTRLFWPHHAWLARYDFLFLAALLIQVLLLAFRMETLREAKVILMFHVIGTLMELFKTHVGSWTYPEANLFRLGHVPLFSGFMYASVGSYLARVWRALDFRFSHYPDRRLTYGLALLIYANFFTHHYLPDLRWLLFAAVACLYGRTWVYYKPYRAYRRMPLLLGFALVALFIWIAENAGTFGNIWVYPDQHSAWHIVHFTKFGAWFLLMIISFILVSLAHIPQAEGGVSTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G5</accession>
    <name>E8X3G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3461"/>
    <dbReference type="EnsemblBacteria" id="ADW70466">
        <property type="protein sequence ID" value="ADW70466"/>
        <property type="gene ID" value="AciX9_3461"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3461"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457685_0_0_0"/>
    <dbReference type="OMA" id="NRQQFFA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230197" evidence="2">
        <location>
            <begin position="27"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="596" mass="67456" checksum="F1029313D97C9799" modified="2011-04-05" version="1">MKDQTRNHMKTKLAFAAHGILLLSLAAGMSGCKQNPATVANGGDPAAGNLAPIDPNAPQQFAGTSSVSNTAPQGQPARVLGQRVEGPTGTASGEAYNQTYGQSAQQNEAYNYNQAPPAGTVDDQNYAYNAQYDDQVNAGQDALDSQAVYADQAPPPLPVYDQPVLTDPGDQWTPGYWAYANTGYYWVPGAWVAPPYSGALWTPPYWGYYNRRYGFHHGFWGRYIGFYGGIPYGFGYTGVGYYGGYWRGRDFYYNREVNRVNVNIVRNVYIHDVPRYNTNVRVSFNGPGGWNARPQANEIAAYREQRFPAMQSQIANRRAAEGNRQQFFAENHGRPAEAVAQQRLVADHAPAQALRTGFGQQGAQQRGLQQGQQQQRGFEAGQQQQRGFVQGQQAQPGQQQRGFEQGQQRGVVPNQQAEQLRNQQLQNQQHGIQNEQVRNQQLQQHNEEIQNQQHNQLRNQQQVTEQRNQQNQQVEQQRNVQNQQMEQQRNQQVEQQRNVQNQAREQQQNQQRVQQQQVQNQRAIQQQQQVQGRQQIEQQHVQQQHVEQPRVQQPQQHVEQPRPQPPQQHVEQPHPQAAPHPQGGGGEPHGEGEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P0</accession>
    <name>E8X3P0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA binding S1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2280"/>
    <dbReference type="EnsemblBacteria" id="ADW69318">
        <property type="protein sequence ID" value="ADW69318"/>
        <property type="gene ID" value="AciX9_2280"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2280"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_1_0"/>
    <dbReference type="OMA" id="LTVDIGM"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="215"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="303"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="390"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="588" mass="62964" checksum="90E92B048BDCE153" modified="2011-04-05" version="1">MDTNTPLPPTTSDVTEDENYDFAALLRENDQERASAVDRSGGSKQIDATVVAVSADTVFLDIGYKTEGILPLSSFPASDKAVEPGDKVRVTVKGRDTDGYYELTRQRTATPKDYSSLEEAFEAKGTVLGTVTGVVKGGLTVDIGMRAFLPSSRSGTRDADEMAKLVGQEIRVRITTLDLEGGESGRPDAVVDRRSVVEEEARASADQRFSELAEGDVVNGTVRSLTEYGAFVDLAGADALLHISDMAWHRVANPADVLSVGDSVEAKILKIDATDPARRRISIGMKQLLPHPWDTVSEQFKIGDKVTGTVTRDADFGAFVEIAPGIEGLIHISEMAWGKKVRKPSDVVKVGDSVEAVILGIDTEQKRMSLGLKQALGDPWAELVKTVHAGSVVEGPVSSITKFGAFVTIAEGVEGMIHISEITAEKRLNHPSDVLRVGEVVQAQVLEIDREKRQLKLSIKQLVPTGIDEFIAEHAVGDVVTGRLIDLDRVSNTARVELGEGIIAMCSIPAEAAPVEDLATKTGPVDLSNLGSLLGSKWKTSAEPSKPAAKGKAVVAPSDDKTLKAGQIRSFRLTVLEPETKKLALELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R2</accession>
    <name>E8X3R2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2303</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2303"/>
    <dbReference type="EnsemblBacteria" id="ADW69340">
        <property type="protein sequence ID" value="ADW69340"/>
        <property type="gene ID" value="AciX9_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2303"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_4_0"/>
    <dbReference type="OMA" id="TLCVNTT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="266"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="37585" checksum="6C41C0CA036192B5" modified="2011-04-05" version="1">MKGIGLWRMLARSLVHRRARSLSALTAMTVSAAVATALLTLYADLDAKLHHEFRSFGANIVVTEPVGEAGLATKGQAAAGANANVAAFGYAVALTDRGTPVVVSGVDFEAVKRLDSWWSVAAWPSGADDALLGDRAANFVADEKAVKLSFAGKEQTFRGAGRVKTGGDEDSRIYVPAAAFTAWTGVAPNVLEVQVPGGGAAVEAALGRLKAALPEARVEPVRQLVDGESRIVDRTHALMFGAVILIALTVAVSVLATLSASVLERRRDFALMKALGGSEIQMMSLFLLETLLLALGGVILGYVAGSGAAWVISEVNFHTATLPHAGVIPAVLLLNGLIAALAALLPIRALRGLEPAALLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S0</accession>
    <name>E8X3S0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2311</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2311"/>
    <dbReference type="EnsemblBacteria" id="ADW69348">
        <property type="protein sequence ID" value="ADW69348"/>
        <property type="gene ID" value="AciX9_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2311"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090616_0_0_0"/>
    <dbReference type="OMA" id="PEKNAYD"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234140" description="Glutathione peroxidase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27174" checksum="8C78A79B67C77696" modified="2011-04-05" version="1">MRLNQSVNLRFGIVVACAVGMGSAAAVRAQEPANQDKTGRGATGHKKAAPDAVGLAPGEGRVGRGGKETQPEKVVYDYELPGADGKGVPLKEYKGKTLLIVNLARNSSYNSQVAALEKLNEKYKEKGLVVIGVPSNDFGAGEPGTDAEIQKVYKVDDKVTFPVVARSKVTGDDELPLYSYLTKEKAVPENGPVHWNYTKFLIDKNGKVVARFNPDVAPDSPEMLSTLDQVLDGRFKPKKAGGPGGPGGGGGDDGDPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V0</accession>
    <name>E8X3V0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2341</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580694.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2341"/>
    <dbReference type="EnsemblBacteria" id="ADW69378">
        <property type="protein sequence ID" value="ADW69378"/>
        <property type="gene ID" value="AciX9_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2341"/>
    <dbReference type="HOGENOM" id="CLU_2584809_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="8885" checksum="0BFBC1470FFD055F" modified="2011-04-05" version="1">MKLVNGTETIPTFLDQATIALMQLSIDHLELLEQLAMELQARTSTSIRLPETTKSLAVQVAIQAATEYPTDGSTERTWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V2</accession>
    <name>E8X3V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein FlgJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2343</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580696.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2343"/>
    <dbReference type="EnsemblBacteria" id="ADW69380">
        <property type="protein sequence ID" value="ADW69380"/>
        <property type="gene ID" value="AciX9_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2343"/>
    <dbReference type="eggNOG" id="COG3951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2206321_0_0_0"/>
    <dbReference type="OMA" id="QAGAKNT"/>
    <dbReference type="OrthoDB" id="2077671at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="107" mass="11253" checksum="66DD31397491E05B" modified="2011-04-05" version="1">MRIDDVVAVQAGAKNTLPNPKLVDGAKDFEAMMLKEMLKPLHFGATDDGANGDSEKGGEADTIQGFALDALGKGLTRGGGFGLAKQIIRQVTAEQSARQSKRVTGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V4</accession>
    <name>E8X3V4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar L-ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2345</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2345"/>
    <dbReference type="EnsemblBacteria" id="ADW69382">
        <property type="protein sequence ID" value="ADW69382"/>
        <property type="gene ID" value="AciX9_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2345"/>
    <dbReference type="eggNOG" id="COG2063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069313_1_0_0"/>
    <dbReference type="OrthoDB" id="1900876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="285" mass="29975" checksum="D84129065B41B851" modified="2011-04-05" version="1">MTTMSVAAEEREMKSGELRQLAGGSHPPVLRFAMLTCGVLLLLLAVSLQAQTVATAAAAPASTQAGKKGLIDRLKPVEKPNVAQSSIATYLARVKADGSTGSASEGSIWSENGRLAHLSTDVRAMRPHDLISVVVSESLAASTDGEVKNSRASNANSQISAFFGLLHAGNAMQNLLNQSSTSGLAAQGASATNSSLSTTFGGQVIDVLPNGMLVIEAARQVEFSQQTQTIVLRGLVRPEDISQQNQVLSTAISSLELEVRGKGIVNDFTHRQNALVRLLEKVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z2</accession>
    <name>E8X3Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3495</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581811.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3495"/>
    <dbReference type="EnsemblBacteria" id="ADW70500">
        <property type="protein sequence ID" value="ADW70500"/>
        <property type="gene ID" value="AciX9_3495"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3495"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_0_0"/>
    <dbReference type="OMA" id="GGATQRM"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="349"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="469" mass="51288" checksum="B4B52C42B6DAD1CF" modified="2011-04-05" version="1">MSSVYDLIVIGSGPAGQRAAIYASKLGKKVAVVEMREVVGGACINTGTIPSKTMREAVLHLSGYNYKSIYGMNYRVKERITMADLAFRVQHVIKTEVDVTEAQLQRNNIEMFVGTASFEGTNDGITQVKVTNSRGATIYDAKNVLIATGTKPASSPKVPINGHSIVNSDLILELKNLPKTLIIVGGGVIGVEYTCMFSALGVRVTLIERRPRLLEFADQEIIEALSYHLRDSRVTMRMNEEVESVDEMPDGTVVANLESKKKVQGDALLYAVGRQGNVDELNLAAVGVESDSRGRIPVDKDFRTKVPTIFAVGDVIGFPSLASVSMEQGRIASARAFGDDTVLSNPSFYPYGIWTIPEISFLGKTEEQLTEEDVPYEVGVAYYREIARGQIRGDTTGRLKIIFHRMTHAILGIHIIGEGASELVHIGQAVMSLGGKLDYFVETVFNYPTLAECYKVAAFNGLNRVSKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X408</accession>
    <name>E8X408_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein MerR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581827.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3511"/>
    <dbReference type="EnsemblBacteria" id="ADW70516">
        <property type="protein sequence ID" value="ADW70516"/>
        <property type="gene ID" value="AciX9_3511"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3511"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_4_2_0"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="22835" checksum="FCB4867E7692616A" modified="2011-04-05" version="1">MAPQESIRKRSGSGGTGASSAREIPDKLYFRIGEVAKLCDVPAYVLRFWEGEFPQLRPNKGGTGQRLYRRRDVEMALRIKTLLYDEGYTIPGARQAFKAELRTTRDTQLGLGDMGEPESAAPGAVDTSHLEAIRKELGELHAMLSRPAVAKSVVQPIRPPRPQPIPRAKTPPAQFPKSKLMLEREKGPTLLDSLFDDLDFDPPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X473</accession>
    <name>E8X473_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0042</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0042"/>
    <dbReference type="EnsemblBacteria" id="ADW67133">
        <property type="protein sequence ID" value="ADW67133"/>
        <property type="gene ID" value="AciX9_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0042"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_0"/>
    <dbReference type="OMA" id="CRQMRQW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="250"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="392"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="668" mass="74301" checksum="7C6075D380491179" modified="2011-04-05" version="1">MNPSILSSERVTSVNVAKEAERLFRSEHRLVCTRTDRLFAILMSLQWPAAVAAALLISSRTWVGGTSSVHPHLIAAVYLGGLITVPPVLLAFFRPGERYTRHIIAACQMLMSGLLIHVSGGRIETHFHVFGSLAFLAFYLDWEVLATATLVTLVDHLAMGYYLPASIFGTATASHWRLLEHVLWVVFFDIFLITSCVQGLKWLHAVARREADQELLLYQAYHDALTGLGNRLQIQKLMGELLMPGSKEPRPFALMAIDLDRFKEVNDTLGHQVGDELLRQVSQRLMAQIRKNDTLVRMGGDEFALVLDGCTSARVAESIAGRMVESLNKPFSLGDHTARIGASIGICLHLDEGQDATDLFHHADLALYKVKNSGRNSFMVFDENMRAETLHQMSMEHRLRSAVLENQMHLHYQPIVSTEGRLLGFEALLRWNDAVHGDVSPVDFIPLAEKTGLIIPLGAWVLQQACSQAAQWHRTGNKLMKMSVNVSSIQLAHKDFVTTVLTALKETGLPAELLDLELTESALIQQHDSSYESLHLLRRFGVKLSIDDFGTGYSSLSYLRDLPVHTLKIDRAFVKDIEISPESRTLVEGMIDMAHTLHLRVVAEGVENRKQMEILVEAGCDEIQGFHISKAVPADDARRFINVSHGEPEIKAMAGAAKVRGLAEVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A1</accession>
    <name>E8X4A1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0070</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0070"/>
    <dbReference type="EnsemblBacteria" id="ADW67161">
        <property type="protein sequence ID" value="ADW67161"/>
        <property type="gene ID" value="AciX9_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0070"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088548_1_0_0"/>
    <dbReference type="OMA" id="CHSRVGN"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="30032" checksum="F496C6FAF910DF55" modified="2011-04-05" version="1">MINPVHRASAALATFGLLFALGCRQDMHNQPKFVPQRGTEFFADGRSARPQVDNTVARGQLHEDTYFYTGMQNGQEGNAMPFPVTMDVMARGQERYNIYCTPCHSRVGNGAGMIVERGYSQAGNFHTARLQAAPLGHFFNVISNGYGAMPDYAAQLTPEDRWAVVAYIKALQLSQNADQGSVAAGQHVERLSDIAEREGLPATFVSEWTTPATAVTGTPNGQPYVLSLDQMGSAGGGSAQHPAQAVASKAPTSPGANPVASGVPHGQTSTGYPMTPTSPGHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D9</accession>
    <name>E8X4D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579589.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1203"/>
    <dbReference type="EnsemblBacteria" id="ADW68266">
        <property type="protein sequence ID" value="ADW68266"/>
        <property type="gene ID" value="AciX9_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1203"/>
    <dbReference type="eggNOG" id="ENOG5033N58">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2954053_0_0_0"/>
    <dbReference type="OMA" id="MNYVDDI"/>
    <dbReference type="OrthoDB" id="2063400at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6710" checksum="06F6E401944399EE" modified="2011-04-05" version="1">MPLSGEAIRMMNYVDDIAVTLRRIQAVLPSLTEEERARVSDYIRNSEPNYESVLIAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J8</accession>
    <name>E8X4J8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580724.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2371"/>
    <dbReference type="EnsemblBacteria" id="ADW69408">
        <property type="protein sequence ID" value="ADW69408"/>
        <property type="gene ID" value="AciX9_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2371"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051474_3_0_0"/>
    <dbReference type="OMA" id="WQVARID"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="61"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="24584" checksum="577310714128870C" modified="2011-04-05" version="1">MSERSNLRRNSGQFEPKRTHPFRRFLLWCFCFLVLAAMGWSSWVVRQINLVAAQDQAQPADAIAVFGAAEYSGRPSPVYHARLDHAVTLYRKQIAPIVITFGGGSDKDSGKTEGGVGRDYLLANGIPFDKIIAETHSVDTEQQVELLAQIAEENNLSHIVLVSDNTHLFRIQELCRRAGLDVYTSPRPALGHIDSYDLFMRYFHEVLSYTAMRLDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M8</accession>
    <name>E8X4M8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA 3'-terminal-phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2401</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580754.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2401"/>
    <dbReference type="EnsemblBacteria" id="ADW69438">
        <property type="protein sequence ID" value="ADW69438"/>
        <property type="gene ID" value="AciX9_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2401"/>
    <dbReference type="eggNOG" id="ENOG50333BR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158701_0_0_0"/>
    <dbReference type="OMA" id="RITREMM"/>
    <dbReference type="OrthoDB" id="2058272at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10953" checksum="D981817FB3A9B235" modified="2011-04-05" version="1">MNASLHRELWTSWASLLRSYAAMAGLNSVHHAVVEVGANEIILRVDTRWLRFTETEQQSSEGMQQGFALNEDGTVTLGGKIEEMDLTAERITREMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T4</accession>
    <name>E8X4T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3569"/>
    <dbReference type="EnsemblBacteria" id="ADW70573">
        <property type="protein sequence ID" value="ADW70573"/>
        <property type="gene ID" value="AciX9_3569"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3569"/>
    <dbReference type="eggNOG" id="ENOG50337X9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172461_0_0_0"/>
    <dbReference type="OMA" id="VWIGISE"/>
    <dbReference type="OrthoDB" id="1796197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12545" checksum="48183D9BCC92A054" modified="2011-04-05" version="1">MPVQPNLFPEPGAPPKPHPAVAAQPRSGTAPLWLQRISLFILVLFCVYLGIIVAILPWWTSVWDHNLFFQSRPWLWSVLRLGAVRGIISGLGLLDIWIGISEAIHYRDDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U6</accession>
    <name>E8X4U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3581</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581896.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3581"/>
    <dbReference type="EnsemblBacteria" id="ADW70585">
        <property type="protein sequence ID" value="ADW70585"/>
        <property type="gene ID" value="AciX9_3581"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3581"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106685_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="26775" checksum="F47ECE1E891E5FB6" modified="2011-04-05" version="1">MYPILFHLGRVALPTFGVLAAIGLMCGLGLSLRTARLLGLDPDAVWNAGLFAVIAAFVLSRVLLIFEHMRIFMQFPGLVLAFPSLTATGVLLTGLATLAWIRVKKLPVLRVLDAWAPCAALVWGFLALGHFADGSDPGMALGAARTHPVGVYAALAGFGMAAGLYWLLAGAGEGVTRIRGIKTDVRGFVCGLGLVGCGVCQFLISFVRVPGKQLYGMDVLQVVALGMVVVGGLLVGGLGPRVTSVEATSRRVREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X1</accession>
    <name>E8X4X1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ordered locus">AciX9_3607</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581921.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3607"/>
    <dbReference type="EnsemblBacteria" id="ADW70610">
        <property type="protein sequence ID" value="ADW70610"/>
        <property type="gene ID" value="AciX9_3607"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3607"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_0"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="35188" checksum="C051DEF5C9BAA378" modified="2011-04-05" version="1">MALKPLIVTLGATASGKTALSLALAQRFSGEILSCDSVAVYRHMELGTAKPSQAERALVPHHCLDLYDPNEACNAGDYARHARAALDEIASRNLLPILSGGTGLYLRALLDGLFPSPQQDPALRELLRHRAATRGSAHLHRTLTRLDQVAAHAIHPNDIPKIVRAIEVSLLARRPITEQWQSGRDALTGYAILRLGLDPPRPELYQRINLRAQAMFTNGLIDETRDLIARFGPDCRPFSSLGYAEASEVLRGELTEAAAILQAQQGHRHYAKRQMTWFRREAELHEVHWLKAPGDSPEAERQAIQLVEKHLQAATLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X8</accession>
    <name>E8X4X8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0079</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0079"/>
    <dbReference type="EnsemblBacteria" id="ADW67170">
        <property type="protein sequence ID" value="ADW67170"/>
        <property type="gene ID" value="AciX9_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0079"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655411_0_0_0"/>
    <dbReference type="OMA" id="EIRYVEY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="211"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="46890" checksum="858CFB7691C130AD" modified="2011-04-05" version="1">MKAPKVRLYIRIRRPDGSTSYLDPAWNANRTLRRGYATVDGKSVGYPNGSYYLRYLSAGKRLWESVGPDPDGALVALRNKEHDLQALALGRPPSGKASSTEVQAQLEVATSASISLDQAVADYLEEIRRFRAPKTLAGCKHTLKLLQRGLPNKMLKDITRKELLNHMSSLKDQGLSNRTAHNHVKRILTFLRSQGVVGLLRATDIPRYEERDAQAYKPEQLALLLAAADPEERIVFEFFLGTGLREQEVMYTTWKNINFKDKVVDVRSKPELGFHIKDKEERSVPVPEWLIAKLIERKKQSSSMLVFPSSIGKANGHFLRVLQKLAYRAGLNCGECVTKSEKSCANHPVCTEWGLHKFRKTFATLHSEAGVSVRTIQKWCGHSSLSCTLKYLAAADLRSERTRNQVNASFAMLNLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X579</accession>
    <name>E8X579_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ordered locus">AciX9_1281</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579666.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1281"/>
    <dbReference type="EnsemblBacteria" id="ADW68343">
        <property type="protein sequence ID" value="ADW68343"/>
        <property type="gene ID" value="AciX9_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1281"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_0_0_0"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="7">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="117"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="39313" checksum="481D724A95D43F91" modified="2011-04-05" version="1">MADERMERVTARQRSILMAIVERYIETGEPVGSGTVAALSGAAAVSPATVRNEMAALGEAGLLEQPHTSAGRVPTAKAFRLFVERLGPLALVSGGARLSDTSRLDIDRRFADVAGTQAVLERTSHVLAALSSGVGVAIAAVPDGDQLEHVHFSHLTAMRVLAVVVTRGGVVRDRVLALKTDLTALELETAARFLNENFRGWEIERVRAEIALRVERERSEYQRMLNSVEQLWVMAVPVTGGVSQTVYVEGVSNLVGSRPMGGADDRERLREMLGALETKQRLVDLLNAYIDTRQESVRVVFDLEEQAPEMAGLVLIAAPARIAGESRGTVAVIGPTRMQYERTMNAVGYIAQVLERQGMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A7</accession>
    <name>E8X5A7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1309</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579694.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1309"/>
    <dbReference type="EnsemblBacteria" id="ADW68371">
        <property type="protein sequence ID" value="ADW68371"/>
        <property type="gene ID" value="AciX9_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1309"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_0"/>
    <dbReference type="OMA" id="NKNYGQT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="36601" checksum="318A56C50B9BD40A" modified="2011-04-05" version="1">MPKYSIVVPFHNEEENVTTLYDRLKAVMEQLNESFELVFVDDGSLDRTYRLLEEIAAVDSRVLVVKLRRNFGQTSALAAGFDHAQGDFILAMDGDLQHEPTEIPQFLAKLEEGYDVVSGWRSERGDNMFLRRIPSGIANRLMAALSGVDIHDFGTTFKAYRREVIQNIPLYGEMHRFIPALASWYGASICEVPISNPARVAGKSHYGLSRTFRVFFDLLTIRFLLKYMTRPLHFFGTIGAAGILSGGVISVWLMALKLLTHTAVHDDHAPYFTIASVLILGGIQMLGIGLLGELQVRHFHTAEHRAPYAVDRILRLRSNEESLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G3</accession>
    <name>E8X5G3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580826.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2477"/>
    <dbReference type="EnsemblBacteria" id="ADW69510">
        <property type="protein sequence ID" value="ADW69510"/>
        <property type="gene ID" value="AciX9_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2477"/>
    <dbReference type="HOGENOM" id="CLU_101338_0_0_0"/>
    <dbReference type="OrthoDB" id="1735815at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234189" evidence="1">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="21156" checksum="65BBB5D7472784D9" modified="2011-04-05" version="1">MRISPNFTFLSLLLLAPAAHAQLSAYVTFSPAHLSNIETGAVSTATGTTEQTASYWSSGIGGGITFPILHLPIVALNVDLRGSTRPGTNGVDSALVGLQLAVHPHVISLKPYIEVAGGYLNTRTTNVSTNPSTNQPVGGTFGNQYAAYEILGGVDHPILPFIDWRIVEIGVGQGFNVPGITTNGKTYNATVVTANTGLVIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J0</accession>
    <name>E8X5J0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3614</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581928.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3614"/>
    <dbReference type="EnsemblBacteria" id="ADW70617">
        <property type="protein sequence ID" value="ADW70617"/>
        <property type="gene ID" value="AciX9_3614"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3614"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="SHSIDNV"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234209" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1252" mass="133842" checksum="820ADABD31362AD5" modified="2011-04-05" version="1">MRKSTLRLALSAATLFAAHGALHAQDSSSMTGLVTDSTGAALPGAVITLRNPSTGAQFTQKTNSRGEYRFANVPPAPSYVATFSHDGFTSIAVNDLALQVGVTRTQDEALAAGTSQEVSVSAGRDVVTINTTDASIGNNIDPTTLVDLPIQARESVAVLFLLQPGVANSSFTGARTDQSSVTLDGMDVNDIAAGSVYGGGGGRITSDAPVDSVQEFRGTVAGLPSGLGTGSGGQFQLVTKGGTNHFHGDLNEYHRDTATEANNWFNKNLTTPVPRTPLIRNQFGGAIGGPIKKDKLFFFFDFNNSRIIQSTNVERVVPLDSFRNGLVSYIRNTDSSTGAACAATSRQNTTPTCIGQLTPAQVQALDPQKIGESTALFNFINSAYPHANDPAYSSADGINTGGYRFNFAEPDFLYNYVGRLDYNLTSKQQVFVRGSITRENSTQSANAFDTTPGTTNPFVDRSYSYVVSHVWQIGQNKVNQFYYGDTIQKFNFPSLLAPTGTTEYGLGGSTNTTSNLFGPYNSYSSQKRRVPIPEFRDDFNWQLGTHNIGFGGTFKFIKTNSQLINDFNSVTLGLGGENLTLDPTVRPTVANGYGVNAIRTAGTTSSAVYDEAFALALGRVASVGSSYNYNAVGIQTPQGTGAVRAYRYFQTELYVGDTYKVRKDLTVTYGLRYQLYSVPYEAHGEQSIQNFTFNNYFAARETQGAAGISGATALAPITYNLGGKANGAAPLYTPSYKDFAPRFAFAYNPSFAPKSVINGSFALVYDRTVINAVNFIQDQSSYLFQNSASTPYGGAGAAAGLGAANPRIGTNLAYTNPNTAPVITKPLSPFIQGGVPVGLADNQFNTIVDPTLKDPYSLTYNLGFQQEMPDHFILKVNYAGRLGRHLLAQADASQLVDFRDPASGQLMSTAFANLTKEVRAGQAYTAQPWFENQAGKGNTVFLANALSSLVSNGDFADYIQALQADGYLGYNVGMASQFAENTFLTNKGTSTYNGLLVTVSKNLSQGLQFDLNYTWSHSMDNVSSNANSISASSGNNFVCDATNPKTCFANSDFDVTTVVNSNFIYQLPFGRGRTFFSNAHTLINEAIGGWSVSGLPAWRSGLSLGTSSNAFVAGYANDAPAFFNGNRADVQAHVKKDPTTGAVYLFGSANASTKAQAEFSGPVGLSFGSRNNLRGPSAFTMDAGLGKVFPLLPNERLNLKFRADFYNILNHPIFNLPNTDITSGSFGQVSSTPTGNSPGAPRVGQFSLRLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J1</accession>
    <name>E8X5J1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3615</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581929.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3615"/>
    <dbReference type="EnsemblBacteria" id="ADW70618">
        <property type="protein sequence ID" value="ADW70618"/>
        <property type="gene ID" value="AciX9_3615"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3615"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_1_0"/>
    <dbReference type="OMA" id="CIHRIKY"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="363"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="450"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="537"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="671" mass="72935" checksum="20C46942C022B7F2" modified="2011-04-05" version="1">MVDDHNPELIESKPLNTEIETLAPEATAENTSMSSDSTPTETTQIPTTPSENPASGQIAPSLSASTSDTEEEAGEVDYDDSDFAAALASFDREQAVDAAAAQNLTAEEVIVTGTLVKITDKHAIIDIGLKAEGLLALDQVNNPDGTPKFAVGDQIEVVVEREETHGGGYIVSHEKALRHKVWDVLEAAANSKTPVKGMVVSRVKGGLTVDIGIKAFLPGSQIEVRPVRNLDGYVGTEIEVRVIKLNKKRGNVVISRKELLEEDQNAKKAVTLATLEEGSVLTGTVKNLTDYGAFVDLGGLDGLLHITDMSWGRLTHPRDLVNVGDEIQVKVLKFDKDKQRVSLGFKQLTPDPWLDATERYPIGAQVRGRVLSVTDYGAFVELEQGIEGLVHVSEMTWSKRMKHPSKLVKPGDEVDTIILSVNPNDRRISLGMKQLQDNPWEALEDKYPTGAIIEGRVRNLTDFGAFIEIEDGIDGLVHVSNLSWTKRIKHPSEVLKKGEKVRAIVLGVEPENRRLSLGVKQLQPDVWDTFFAQHRIGDVIKGKVLRTAQFGAFVEIAEGVEGLCHVSEAVDATGKPVELKVDDEHEFKIVKMNQEEKKVGLSIRAVGEEASRAEVESYKEQAHQSNSGGGGKKGGQGNQGSSSSSGSSSSTTLGDLLNWKRAEREGEESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L1</accession>
    <name>E8X5L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3635</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3635"/>
    <dbReference type="EnsemblBacteria" id="ADW70638">
        <property type="protein sequence ID" value="ADW70638"/>
        <property type="gene ID" value="AciX9_3635"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3635"/>
    <dbReference type="eggNOG" id="ENOG5033B3J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705489_0_0_0"/>
    <dbReference type="OMA" id="CFAAMER"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="42166" checksum="86828AE293577518" modified="2011-04-05" version="1">MMDGGRVRFRVIACMMFLLVCQLGYLAAGVKTGLAGFADFRAFYGAGAIVRMGAGARLYEYELQHQVQNERVGERTAALPFVYPGYAALPFAAVTGLGYRTAYWVFLGVNVVLLGVAVWLMLPWLQGLTAVWRGLPWMVFGCFYPVAVALLQGQVSVALLVIVCGCFAAMERGRMFLAGAVLALGLVKFHVVLPVALLFCWWRRWRFVGGFAAGAAGVGLACLWVTGWAGMVSYARLVVTAAGTGSVGAALDDSMRNSGRMPNLHGLVFAMAGDARWGTVVVGVLSVGVLVWTARQGASLGRAVVAGLLVSYHLHLHDVSLLLLPLGLALNGMSLERVRSLWVRGATVFWMVSPVLVWVAGMGWNFVLAVTMIPFLVRWERDKGDGLEAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U5</accession>
    <name>E8X5U5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dyp-type peroxidase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70829">
        <property type="protein sequence ID" value="ADW70829"/>
        <property type="gene ID" value="AciX9_4033"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4033"/>
    <dbReference type="HOGENOM" id="CLU_015125_2_1_0"/>
    <dbReference type="OMA" id="FHELGNE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="50851" checksum="F7426D888948EBFC" modified="2011-04-05" version="1">MSKLNATDIQGFVLRGYNLPLARYYFLHFEDSVRARALLLKLLPKITTGQTWDGGKPQSTLNIAFTHPGLAAFDLPDATLLSFPVEFQQGMKKRAAILNDTGRNAPERWDECWTEGLVHAWVAVNAMTPAALASGHAELIGLLEEVGGATILATQDAAAAVAGGKPTTKEHFGYTDGFGNPDYLGVERSVQPGQGKLMPDGSWAPLATGELLLGYADEAGELPVAPVPHLLASNGTFMIYRKLHQNVATFRKFLADEAGRYGAGDDYSKEKLAAKLIGRWRDGTPIELSPDGPDFALTQDPNRSTNFTYGGDADGTRCPMGAHIRRVHPRDAFGFEGRLVHRRRITRRGLPYGRFAGENEPVADTDDRGVVFMALNASISRQFEFVQQQWIEYGNDAHLGNDKDPLMGNHDGSGRFMVQGDSSKSNPPHLCRHLPQFVELRGGDYFFLPSITALGMLAMGLVDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X691</accession>
    <name>E8X691_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572887.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70975">
        <property type="protein sequence ID" value="ADW70975"/>
        <property type="gene ID" value="AciX9_4196"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4196"/>
    <dbReference type="HOGENOM" id="CLU_020356_0_0_0"/>
    <dbReference type="OrthoDB" id="407855at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="229"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="774" mass="80838" checksum="05BDA34DFA911CF9" modified="2011-04-05" version="1">MSQYEDEKNDRRNDEAKATNVNPRRRFLKNAMFGAGGVVATASLAGCADGSHAATSDTVTFTVPSHVYGDVPFGVSATAMSSGQITYTVVSGPATIAGSTVTLTGVGTVVLQASAAADSSYAAAMQQASFTVAPGTPAIAFTVPSLAFGDAPFTVAATSNSTGAFTYSVVSGPATINGATVTLTGAGTVVLQASQAAATPYAAGTQKASFTVSAGAPANTQVPSAAAWKFGIMADSQWYQTDDGYNPFSVAVDIRNHVLQQMINNKVKFVAHVGDLTSNAANSGQSLDIYGHALFCQSLYNAGIGYFTMRGNHEDSSDCATALPIAFPQTQTGVHNSAPAVVTGYSNPDTKTLPTPVNTGAPFTLGTNLSSPDPWGTGDLKGLSYSFDYNNARFVTLDQFTPSDAATNKQYSITTSVAAQQPWISAQLAGRTAGSHAFLLTHKGLNLPYHTDVLLGNDPSQNATATDAFMASLSQNGVRYLICGHDHMHDRSIVTANDGKSSPVTQLVSSSNSNYNYFPRNATVSPGDKLNDSYTSVRRRKIVAQELNTFGYYIVTVDGPNVTFEFYSSPSYAAFDLGQHQWDLASVTTVPATPPLNFSLHETFGYSLVGKDFQIPFGSAFTVVSDTSPNGTVAKLLSGSNVVQDTDYSGYQFVRSVSTGWATGSGAQVSDIFYLWGLHSTLVSSQSETYALQMSYNAGVSSALLNAGKVYIGAIGDGGGWVNAASANFGGTPVFVLGAWNSSYPLGTYGVDVANGVAWAVVNYDGVFAVTQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X696</accession>
    <name>E8X696_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-demethylubiquinone-9 3-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4201</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572892.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70980">
        <property type="protein sequence ID" value="ADW70980"/>
        <property type="gene ID" value="AciX9_4201"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4201"/>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_0"/>
    <dbReference type="OMA" id="DQDEVDY"/>
    <dbReference type="OrthoDB" id="1889762at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="162" mass="18000" checksum="909E163D63BED822" modified="2011-04-05" version="1">MTLQPQKVSPFLWFNDQAEEAMDFYTSTFPDSKQLRVARYGETGPGKPGSVMTADFELFGQRFTALNGGPHFAFTPAISFVIHCEGQAEIDEYWDKLAAGGTIMQCGWLTDKFGITWQVVPNNLAQLLSNPDPATAARVMKAMMSMKKLEIAPLEQARDQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B5</accession>
    <name>E8X6B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4222</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572911.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70999">
        <property type="protein sequence ID" value="ADW70999"/>
        <property type="gene ID" value="AciX9_4222"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4222"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_0"/>
    <dbReference type="OMA" id="HATRFAN"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230790" evidence="2">
        <location>
            <begin position="34"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="57"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="613" mass="68283" checksum="47F0E7F7681C8B2C" modified="2011-04-05" version="1">MHHSTTRPARFRALAPLFAALILAASASLPAPAQTVPVNIAAPVTSDVWWKHAVVYEIYPRSYQDSNGDGLGDLNGITQRLPYLQSLGVDAIWIAPMYPSPQVDFGYDISNYESVDPQYGTLADMDKLIAAGKQHNIRVVLDMVLNHTSDKHQWFIDSASSRTNPRHNWYVWNDGIPADGPGVTAYQKKYEHEDLNGKKVVPPNNWTSGFGGSAWEWVPAVHQYYYHFFYIQQPDLNWRNPEVEKAAFGAMRFWLDRGVAGFRLDAIPTLFEDPKLTNAPELGGLNKQGDPNLSDKYQSNLPEVHDVIRRMRAMVASYAGNRVLIGETYLPDTAALVPWYGGEKLNELQLPMNMLVGFHGDHDKLNAASFRTRIEEAENILPGSQPLFVFDNHDNVRSWERYGDGVHNEAIARTIAAVLYTSRATAMTWEGAEIGMVTTTPTRKEDVKDPIGITGWPNEKGRDGERTPMQWDTSKNAGFSTADKTWLPVPPNYKTINVATEEKEPDSLLNWNKKLIALRRSNRAMHDGGLTMLNPNDPSVLSWLRSTAPGQPAVVVAMNMSAEPKTISLDLSTTGFKGKTVKTLLTDQPSLANTSTVTNITLPPFASWIAQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6F2</accession>
    <name>E8X6F2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572948.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71036">
        <property type="protein sequence ID" value="ADW71036"/>
        <property type="gene ID" value="AciX9_4261"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4261"/>
    <dbReference type="HOGENOM" id="CLU_070775_1_0_0"/>
    <dbReference type="OMA" id="KEFWPDI"/>
    <dbReference type="OrthoDB" id="1448647at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234240" evidence="1">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="29569" checksum="67FF65C90BBFA865" modified="2011-04-05" version="1">MTISSDFRVSHSPRLFSLLVIGLTLSSFATYALAQTEITTKSEALEATTDVSSSLPESPDAALIGQGATARSTASVSNTPSKRVLGIIPNYRSVGVGAQLPPQTIRNKFITAASDTIDPSSFALAALLAGYNDARAATPEFHGGAVAYGRYFWHSFADQSIENVSVEFLVPAFTHEDTRYYTLGTGGKKKRLEYSLTRIFVTRSDSGKETINLSELLGAGLASGVSSRYYPVSQRDAGSVLQQYALNLGIDAASYALREFDNDISRKFSRKHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I6</accession>
    <name>E8X6I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572980.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71070">
        <property type="protein sequence ID" value="ADW71070"/>
        <property type="gene ID" value="AciX9_4302"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4302"/>
    <dbReference type="HOGENOM" id="CLU_914535_0_0_0"/>
    <dbReference type="OMA" id="MITFENP"/>
    <dbReference type="OrthoDB" id="1421966at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233745" evidence="1">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="30051" checksum="D36EF896AE4739C0" modified="2011-04-05" version="1">MPVHLSYIRKVNFKIFPVLAFAVSLTSVAVAQDTLVKALKQKYRVTEINSQGVAANPGTVLTIEADGINAEPYPTMITFENPVVDGQVKQRSKGLGFLKSNNLQILQPGQKVYITKINEDTQGKEDALKLTILTSDAVLATYTNGTYGSQYQAAKRYSTTLSFKEPKGTLAQMSVDDASKMIEAVLSVNAGDQVRTRDAGTIARSCEPHCAVSATTGAPVGGAGITQAAPQSAPPTVALGQTPAQVTATMGAPAQIIDLGAKQIYKYPDMKIIFVNGKVSDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P6</accession>
    <name>E8X6P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71196">
        <property type="protein sequence ID" value="ADW71196"/>
        <property type="gene ID" value="AciX9_3920"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3920"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_4_0"/>
    <dbReference type="OMA" id="HEYLMRR"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="294" mass="33669" checksum="98369681631AD99E" modified="2011-04-05" version="1">METHNELGEKQFLIGLNPGPPPDYVAHDYSDYSVYTAEQHRSVWERHTHDCTQITVAMSPAQVRGEWQGANGHIERREMNGDMAWIVPPNIPHVIHFDRPATLIHLYLTESFFHKMVENAPESVELSLVPSILVRDNFLVELAHSLHRESQYGKLSPLFTDSIATLTATHLVRSYSNTTRSVPAFRGGMGPSRERRVLSYIAEHLNESITLEELARVAEISPNYLIALFRQSMGMTPHKYVVQTRVEHARTLLKQRDLPLLEIAHRCGFQDQSQFTTVFRRYSGLTPGQFRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X750</accession>
    <name>E8X750_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4331</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573003.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71284">
        <property type="protein sequence ID" value="ADW71284"/>
        <property type="gene ID" value="AciX9_4331"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4331"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_0"/>
    <dbReference type="OMA" id="YEATHEC"/>
    <dbReference type="OrthoDB" id="351701at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="387"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="582" mass="63218" checksum="0581F92556C8D4F9" modified="2011-04-05" version="1">MNASDVLVERLLAWGVDTFFGLPGDGINGVMESLRKAQDKIRFIHVRHEESAAFMACAYAKFTGRLGVCLATSGPGGIHLLNGLYDAKMDQQPVLAITGMQFTDVTNTFGQQDVELDKLFMDVCVYNTRVMSASHMEPAADLAVRTAIMKRGVAHLTIPIDIQIQDVKIAERSDRNVAHHTSTNSAISGNLPQANELKLAADLINHGKRIAIMAGQGALHATDELLQLAELMGAPIIKPLLGKGVIPDESPYTTGGIGLLGTKPSQDVIENCDTLIMVGTSYPYMEYLPKPGDAKCIQIDANAQRIGLRYPADVGLVGDSKKTLQMLLPMLKKNSYRKFLERAQEDMKDWIKTLEKEGTNPAKPMKPQVVGWELGKRAKENAIIVSDSGTNTTVWARYMLSKQGQQHSCSGNLATMACGMPYAIAAQVAFPDRQVIGVVGDGGFTMLMGEIITAVTYKLPIKLVIIKNNTLGQIKWEQMVFEGNPEYQCDLLPIDFVALARAVGAEGVRIDDQATAGEMLDKALAMPGPVIIEAVVDPFTAMLPPKITPTQALHFSESLMKGEPNRMKIALTAASDTVRQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C0</accession>
    <name>E8X7C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4404</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71354">
        <property type="protein sequence ID" value="ADW71354"/>
        <property type="gene ID" value="AciX9_4404"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4404"/>
    <dbReference type="HOGENOM" id="CLU_038957_1_1_0"/>
    <dbReference type="OMA" id="VRPWWRS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="40864" checksum="3BD9E8FD67516BBD" modified="2011-04-05" version="1">MEDHATYKAFAARESDPRRRNVMRGLAAAERHHAHLWAHEIGTLDERKLGYSGPPEGLAPVNAKENANIDSQLQHLKIHERSEIDRYSKQMHTLKNEACHKILLEVIADENEHYKALSNLIRARPPLPMMDGSQARKALATLLAARKKRHLEAAGWLNDAVYAAHDGLGSIFGIVSGVAGATFGKSHYVMIAGLAGMVGSALSTGTGAYLTARSERELYEAEIVRERQAVDYDESESREVLALSLQVRGLPEDVAERLSHLLAENKEGFVKALARIRANVSEENLSDPWRAALTGVVATAVGAFVPIIPFFFLSGMPAIASAAVVSLCAHFAVGASKSLMTVRPWWRSGLELTAFGAVEGLTTFAIGIALGRMVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F3</accession>
    <name>E8X7F3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4441</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573106.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71387">
        <property type="protein sequence ID" value="ADW71387"/>
        <property type="gene ID" value="AciX9_4441"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4441"/>
    <dbReference type="HOGENOM" id="CLU_2117568_0_0_0"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="12393" checksum="01BEB0B88D868C57" modified="2011-04-05" version="1">MDVDYKGFSKALGERIRKFRKERGWKHSDIIANSGINDSQWRKYERGSGITAESMLKIAACFKMSVSDLLRGLGDGPIATPGSAPEAVFPVQATARNSVNTKPPAVPRSAKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H6</accession>
    <name>E8X7H6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4464</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71410">
        <property type="protein sequence ID" value="ADW71410"/>
        <property type="gene ID" value="AciX9_4464"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4464"/>
    <dbReference type="HOGENOM" id="CLU_1978404_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13646" checksum="C08D1E878DC10D6A" modified="2011-04-05" version="1">MKWLVLTAIALVFLVTAISIPVIRNNKRSDLRVEQLRSNAELAMENSHLAHALLGENLRTVGSASINLHEQGDSGTAQLNLPVSGTRNKGLLNVEANESGGVWKIENLDIRVDGNSAWSSLLRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L6</accession>
    <name>E8X7L6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4506</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573169.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4506"/>
    <dbReference type="EnsemblBacteria" id="ADW71450">
        <property type="protein sequence ID" value="ADW71450"/>
        <property type="gene ID" value="AciX9_4506"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4506"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037308_0_0_0"/>
    <dbReference type="OMA" id="RFVCGTE"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="402" mass="44003" checksum="9702F31D570877BA" modified="2011-04-05" version="1">MSNTIGVAIIGAGPYGLSLAAHLLGRGIKHRIYGKPMGMWQTQMPDGMMLKSEGFASSLSHPDGAFTLEDYCQEQGIPYADIGIPVSRDTFVSYGLEFQRRFAHRLEQTLVTKIVRDGAGFQLTFDDGSTSMASQVVVAVGISHFQYTPPVLASLSPDRLSHSSRHNNLSHLRDKKVVVVGGGSSAVDIAIHLDAVGSHPELVTRRSEISFHNPPEKTKRPLHRRIRYPRSGLGVGWPARLAEDVPLLFHKMPVEFRFRTVHQLLGPSAGWTTKEKVLGRIPVHTGLSLKNAAVENNHVRLTFQEGDGSPKELSADHVVAGTGYKTDLRRLPFIDQNLYQDISSVEESPILSKHFESSVPGLYFVGASAANSFGPLLRFACGAEFTSRHLSKHLSSKAARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q5</accession>
    <name>E8X7Q5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4558"/>
    <dbReference type="EnsemblBacteria" id="ADW71489">
        <property type="protein sequence ID" value="ADW71489"/>
        <property type="gene ID" value="AciX9_4558"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4558"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044324_0_0_0"/>
    <dbReference type="OMA" id="WTGITAF"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="484" mass="53788" checksum="CF375D1E6BA1B547" modified="2011-04-05" version="1">MLSIPDAAAKDLPLRLGLSQAHFLAAFPIGTPDSRGVRLIQLSEATIDESSLPTAARKPGKRMRPTQSVNGLNETFLKSAGPLDLVFYDVNDPEDKRFWAGTAFYIIGGLRKAGNHVHVIGRLAPRLRRLLIAAFYHSYRLTQKLHYHPDRHLALTKLFSAIGTRRLQKYPSADAIITVSAAFSAYLRTSKPIIVLLDATWGQIVETYPYFHSSMQPKHIVASGFKLDQIAFSKPNLHLVMTSQWAAGRAIVDYNIHPARVHILPFGANFREDPARENVERALRNRSGERCSLLFVGREFERKGGPLAVQIAGELRTFGIDVTLHIVGCSPQNLPSFVKVHGLLSKDSVEHLSLLDTLYSESDFFLMPSTAEAQGIVFNEAAAYALPVAASDVGGVSAVVSNGDWGLLLPPGAEAKEYAVWLAALFRDRPRYIRTALRARDDYEKRLSNTAYTRELTKIVQSIVQAHERPALLKDRSIDRSVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S2</accession>
    <name>E8X7S2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573225.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4576"/>
    <dbReference type="EnsemblBacteria" id="ADW71506">
        <property type="protein sequence ID" value="ADW71506"/>
        <property type="gene ID" value="AciX9_4576"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4576"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_4_0"/>
    <dbReference type="OMA" id="MPNVVME"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="355" mass="39271" checksum="324399A53E462A9C" modified="2011-04-05" version="1">MRIFHILNSLTNKGNGIVNVTVDLAAEQARNGHTVVIVAGHGEYAALLPKLGIEYFFLDQRVSAVNLVKASVLLFRKIKAFRPDIIHAHMRTSLLLAWLCTRFPRYPLVAHLHNVHDPESALMRVADRVIAVSQSVSETMARTIPKWKLRVVLNGPLQSARTAPFTSIPPRMLIRPAITTVAGLNHRKGIADLLEAFDLVLLRVPNAQLYLVGDGPERVLFEAQAKLSPHCDQIHFEGWQAEPQGYLMMTDVFVLASRRDSLGLVLLEAREAGCAIVATHVDGIPEALDGGTAGILVPAKNPSYLADTISNLLLDPALKQTWQKNAQKGIENFTCARMTVKVQEIYDELIESLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y1</accession>
    <name>E8X7Y1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway VirB3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573284.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71565">
        <property type="protein sequence ID" value="ADW71565"/>
        <property type="gene ID" value="AciX9_4635"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4635"/>
    <dbReference type="HOGENOM" id="CLU_2478980_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007792">
        <property type="entry name" value="T4SS_VirB3/TrbD/AvhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05101">
        <property type="entry name" value="VirB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="10122" checksum="E1E168E7F5163CBB" modified="2011-04-05" version="1">MTKRGEALPINQAMNRSRTKLGLELSAWMAIVFVSVSVFLVGFRMLAVISFPLLVAAAWFTVRNHPKMFQLWGHSLYQKSYYDPRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X837</accession>
    <name>E8X837_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4694</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71621">
        <property type="protein sequence ID" value="ADW71621"/>
        <property type="gene ID" value="AciX9_4694"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4694"/>
    <dbReference type="HOGENOM" id="CLU_111671_1_0_0"/>
    <dbReference type="OMA" id="GKLCGRQ"/>
    <dbReference type="OrthoDB" id="1942143at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="17193" checksum="E401345F9BED53A3" modified="2011-04-05" version="1">MKQTLKKWFVSSVVLLAGAGFVYGQSTEGKRLMNHATGPFEVKVVPSGHTPSGSEEFGEMSFTKVLSGNMVGTSKGLMLTSSTSSSGAMAYVALETVTASLHGSSGTFVLMHNATTRKGEPEADSLHIVVVPGSGTGALTGITGTLVIQKGAQGNHFYSFEYDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV98</accession>
    <name>E8WV98_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0199</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578601.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0199"/>
    <dbReference type="EnsemblBacteria" id="ADW67273">
        <property type="protein sequence ID" value="ADW67273"/>
        <property type="gene ID" value="AciX9_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0199"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_0"/>
    <dbReference type="OMA" id="VMCSYQM"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233401" evidence="2">
        <location>
            <begin position="39"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="444"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="870" mass="93796" checksum="904C75708901C6CF" modified="2011-04-05" version="1">MFLKHGTTNFPAPFQTRTKRVQALALAATLLALPAAYAQAPHPLDEVDQQKVDALIHQMTLQQKLDYIGGTGFAAMAVPSLNIPALEMSDGPYGTRSNSGFPSTTYAAGINLAASWDRDLAVRVGAGIGRDARARGVHFMLGPGVNIYRSPRNGRNFEYFGEDPFLSGQIATGYITGMQAQGVAATVKHFLGNNSEFLRHDSDTVIDERAVREIYLPAFEAAVKQGHVSAVMDSYNLIDGKHATQNPYFNIDILRKEWGFKGVLMSDWDATYDAIGAANGGLDIEMPTGKFMNQANLMAAVQSGQVPEAVIDDKVRHILSTAETYGWLDSTHNQRDTNISFLDARNKAAALDSAREGAVLLKNAGNILPLNKAALKTILVVGPDAYPAQVVGGGSAGVVPFAAVSGFQGIVEAAGPGVNVLYDRGLPTLSHLSSDTRMTTAVTGGQAGVTLETFSNVDLQGPAVATSITPHIALDGFNIKMLLDNLEAAMSMIFSTPPKQVSHRFTGFYDAPTAGKYILALEDSGEGSGNRVFVDGQLVVDNWKVVRAFQPHVALDLTAGSHKVIVEEFQVSPVGGHLIFAIAPQNNIVNPRAVQLAAKADVVVIEAGFQQESESEGGDRTFELPYGQAEMIREISAANPKTIVTITSGGNVNSSTWIDRVPGLLETWYAGQEGGRALAEILFGDVNPSGHLPATFEKRAEDNPTFNTYYPEGDTKRVTYKEGIFVGYRGYEKNNIQPLFPFGYGLSYTTFKFGGLKVQQKDMNGETRVTATFEVTNTGSRKGAEVAQLYVTEDKAKVARPIHELKGFERVELNPGETKHITIPLDARSFSYYDVAGKKWTIGTPKFTISVGDSVANLPLKSSLTLKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA4</accession>
    <name>E8WVA4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha amylase catalytic region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0205</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578607.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0205"/>
    <dbReference type="EnsemblBacteria" id="ADW67279">
        <property type="protein sequence ID" value="ADW67279"/>
        <property type="gene ID" value="AciX9_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0205"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_2_1_0"/>
    <dbReference type="OMA" id="YNRIVEC"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="179"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="689" mass="76909" checksum="C2008F5F97703C99" modified="2011-04-05" version="1">MPVPESAKSQSATLPSWNAVEGTPLPLGATWLAEDNAYNFAVFGRHARAMRVLLYAADEFTTPCFSFDLDPLQHKSNDIWHCRISAADAGQAIAYCFQAEQADPILSGEGTLYPAGKQLLDPYARQIVLPPDFDRQQAIDPGPNAGQAFLGDLPPRLQQPFDWGTDKSPQHDGDLLIYEMHVRGLTRDPSAQVTEPNAGCYLGVIEKIPYLKDLGVTAVELMPVMQYELGTANYWGYMPLAFFSPHCAYASSAAKAVAEFRQMVIALHAAGIEVLLDVVFNHTAEAGNDGPCYGMKGLDNISYYMTRSFPPPAYADFSGTGNTLNCSNRAVSKMILDSLRYWVKEMHVDGFRFDLASVFSRDADGNILSGDPPIFAAIAADPDLANIRLIAEPWDAGGAYQLGRSFPGLSWLQWNGRFRDDIKRFVRSEPGLVATIMRRIYGSDDLFPEDLADAKHPYQSINYFTSHDGFTLYDTVAYDTRRNLANGANNTDGPSDDLSWNCGWEGDEGAPADVLELRAQQARNFCALLMLSNGTPMLRMGDEFLQTQQGNSNPWNQDNATTWLNWNRIEENRATFDFFRTMIAFRKHHFIARSRFWHDDIQWFGVTGAPDLSWNSHTIAYFLRSPQDESTDIYVMINAYWEPLTFTVQTPGPWSIALDTCLQPRNAQTAPLTSVQVRARSIVILTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF1</accession>
    <name>E8WVF1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1339</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579722.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1339"/>
    <dbReference type="EnsemblBacteria" id="ADW68399">
        <property type="protein sequence ID" value="ADW68399"/>
        <property type="gene ID" value="AciX9_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1339"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="VIMTGMT"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="129" mass="13853" checksum="4EA10E6E3E7C49A7" modified="2011-04-05" version="1">MSDSATAVTSKPKVLVADDEQVIANTLAIILNQAGFEARAVYSGEKAIESLDTFEPDMLISDVIMTGMTGIEAAIATRAKRPNCKILLFSGQAATADLLEKARAQGHEFEILAKPVHPTDLLAKLRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF5</accession>
    <name>E8WVF5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1343</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1343"/>
    <dbReference type="EnsemblBacteria" id="ADW68403">
        <property type="protein sequence ID" value="ADW68403"/>
        <property type="gene ID" value="AciX9_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1343"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_0_1_0"/>
    <dbReference type="OMA" id="RITIMRR"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="35664" checksum="46C76FB2B951E37A" modified="2011-04-05" version="1">MNLMPYGTDMTDRSKAMHTPLAGLFVAATVLLLCPGQLSAQFSGPAVHVPSTANVIPVPTADPAVLNPNQSDLVINSGDLVQVRIFGSPDFSVPTRVSIDGTLQLPLIGVVTVKGLSVNDAETLIAQKLIAAGMYVNPQVTVQVTEASGQTATVSGEMHAIVPLSGSRRLLDVLAVAGTLPVNASHIITVLRVGADKPIIVDLGTDPSQSAAGNIPIVPRDTIIISRVGVVYVVGAFAKQGAIPLDQNSPLTLMQLTALSGGVGFEGKYDDLRIIRTVGLERKLVKVDIKRVLLGKNPDPVLEANDIVFLPSAPLKAALKSNGIGTAASIASLFIFALQRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM8</accession>
    <name>E8WVM8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2527</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580872.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2527"/>
    <dbReference type="EnsemblBacteria" id="ADW69557">
        <property type="protein sequence ID" value="ADW69557"/>
        <property type="gene ID" value="AciX9_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2527"/>
    <dbReference type="eggNOG" id="COG0033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_8_1_0"/>
    <dbReference type="OMA" id="HHGMMST"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="322"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="486"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="561" mass="60742" checksum="4B1E9C616D4F9643" modified="2011-04-05" version="1">MKVDPRAGQPAMASDLVDVQKLVAAYYEERPDSGIPEQRVVFGTSGHRGSSFEKTFNEWHILAITQAICLYRKQQKIGGPLFLGIDTHALSQPAVESALEVLAANGIDVMLAGREEYTPTPVISHAILTYNHGRTTGLADGIVITPSHNPPDTGGFKYNPPHGGPAEEKITAWIEERANECLAHQLKGVQRISIDKALAAPTTHRHDFLTAYVDDLHNVIDMDAIRSSGLSVGVNPLGGAGVHYWEPIAKCYGLNLKVVNETVDPTFRFMTLDWDGKIRMDPSSEYAMRPLIALKDKFDLAIACDTDHDRHGVVTRSVGLLPPNHYLAVCADYLFQHRPRWSKDMAVGKTVVSSSMIDRVAARLGRKLYEVPVGFKYFVDGLLHGGLGFAGEESAGSSFARMDGSVWTTDKDGIIAALLAAEITAVCKKDPGELYAELSGKLGNSRYRRSEAPATNQQKAALEHITAKDIHTADLAGEKPITIRTKAAGDGNPIGGIKVAAANGWFAARPSGTEAIYKIYAESFSGEELLALIEAEAQTVANQAFASAALATMNREPQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ4</accession>
    <name>E8WVQ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580898.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2556"/>
    <dbReference type="EnsemblBacteria" id="ADW69583">
        <property type="protein sequence ID" value="ADW69583"/>
        <property type="gene ID" value="AciX9_2556"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2556"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_15_3_0"/>
    <dbReference type="OMA" id="CSHATLE"/>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="139"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="44580" checksum="3238F14C95942B6D" modified="2011-04-05" version="1">MPWKESRILDQRLQFLSSYQKEEMSVADLCRAYGISRPTAYRWINRYNETGPEGLVDRSRRPHTCSHATLEPMENAILVLRAKHPSWGARKLKARLEMLQPELVWPAASTFGNILSRAGLTSPQKKRKRITPCSEPFSMVTGPNQLWCMDFKGYFVTGDGKRCDPFTITDAYSRYLIRCQIVSRIDLSQVRAICEAAMREYGMPARIRTDNGAPFAGTGLMGLSKLALGWMKLGIVHERIQAGRPQQNGRHERMHRTLKEDTTKPPASSLRAQQSRFDNFRYVFNNERPHEGLKNAVPASLYHPSSVRLPRKLPEFTYPKGLLLRKVNNSGDISWHKTRIFISEVFRFEELALELTTPGFYRVYFRDLEVGELNAEELRFRAARRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT1</accession>
    <name>E8WVT1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">msrB</name>
        <name evidence="5" type="ordered locus">AciX9_3689</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581999.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3689"/>
    <dbReference type="EnsemblBacteria" id="ADW70690">
        <property type="protein sequence ID" value="ADW70690"/>
        <property type="gene ID" value="AciX9_3689"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3689"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_0"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="14985" checksum="066F5DA7DC7B96F9" modified="2011-04-05" version="1">MSDTQTAPKVQKTEAEWRETLTPEQYHVLREKGTERAFTGALVNNHDDGIYRCAACDAPLFASDTKFESGSGWPSFFTPITPGAVATIEDRTHGMRRVEVTCANCGSHLGHVFPDGPQPTGERYCMNSASLSFEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW06</accession>
    <name>E8WW06_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578640.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0238"/>
    <dbReference type="EnsemblBacteria" id="ADW67312">
        <property type="protein sequence ID" value="ADW67312"/>
        <property type="gene ID" value="AciX9_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0238"/>
    <dbReference type="eggNOG" id="ENOG50330EP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139601_2_0_0"/>
    <dbReference type="OMA" id="FRGHGGW"/>
    <dbReference type="OrthoDB" id="2053555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="13330" checksum="5DF264E8B189133E" modified="2011-04-05" version="1">MKGYRLWKAVKILVMVVVCAAVFGLVVMQLWNWLMPAIFGLRTLTFVQALGLLVLSKVLFGGFHRHGHGGGRGWRRGMGERWEKMTPEERERFKAGMRGRRGGWCEPRESAKEEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW66</accession>
    <name>E8WW66_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0300</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578700.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0300"/>
    <dbReference type="EnsemblBacteria" id="ADW67372">
        <property type="protein sequence ID" value="ADW67372"/>
        <property type="gene ID" value="AciX9_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0300"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="NVLRKTQ"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="190" mass="20061" checksum="89ECC8FF4252162A" modified="2011-04-05" version="1">MVLGALAALLELEPDIAVVAKAANGREALKAAEQTGVDVLVTDIEMPGMTGLEVAGALKVSRPGVKAIILTTFARPGYLRRALDAGASGYLLKDRPASELADAVRRVHRGLRVVDPALATEAWSAEADPLTDRERQILQRAGEGRSSGEIAGELRLSEGTVRNYLSEAISKLGAANRVDAARIARAKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW72</accession>
    <name>E8WW72_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar FlbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1396</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579777.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1396"/>
    <dbReference type="EnsemblBacteria" id="ADW68455">
        <property type="protein sequence ID" value="ADW68455"/>
        <property type="gene ID" value="AciX9_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1396"/>
    <dbReference type="eggNOG" id="COG1582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173020_0_0_0"/>
    <dbReference type="OMA" id="ILHEAWP"/>
    <dbReference type="OrthoDB" id="2007051at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10269" checksum="A7BD05C3758AE10F" modified="2011-04-05" version="1">MIDLTRLNGHRLILNCDLIRFAEPAPDTTITLVTGEKLIVRESCDELIARMLAWRGSVLRTAWPDAASALFAKTDDLAHKHAHAHPKHDSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW89</accession>
    <name>E8WW89_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1414</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579794.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1414"/>
    <dbReference type="EnsemblBacteria" id="ADW68472">
        <property type="protein sequence ID" value="ADW68472"/>
        <property type="gene ID" value="AciX9_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1414"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="79"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="428" mass="46548" checksum="CB44E557BD8AF009" modified="2011-04-05" version="1">MEYSCQTYQLKCNECGRTYGNRPLSGCPECLAPLEIHYDFEAIQKQTPITRQSIQNGPHNIWRYAAMLPIPEGFEPDLPVGFTPLIRAKNLGKRIGASNLYVKNDSVCFPTLSFKDRVVSVALANAQKFGFKTVGCSSTGNLANSVAAQAARLGLDACILVPADLEPAKILNTLVYGARLVRIDGNYDHVNRLCTQIADEYAWGFVNVNLRPYYAEGSKTQGYEIAEQLGWRLPDNVVCPMAGGSLIRKIRKAFNELIALGLVEDKPVRFFGAQATGCSPISQSVRQGWDYIEPQRPNTIARSLAIGNPADGPAASKMIRATGGWAEDVSDVEVVSGMQELAESEGIFTETAGGVTTAVTARLYAQGRISPDETTVVCITGNGLKTTDALVGRFDHLDARAVRPRLSDFADYLRELDGVTENELVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM2</accession>
    <name>E8WWM2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ordered locus">AciX9_3767</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582075.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3767"/>
    <dbReference type="EnsemblBacteria" id="ADW70767">
        <property type="protein sequence ID" value="ADW70767"/>
        <property type="gene ID" value="AciX9_3767"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3767"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_0"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="222"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="232"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="456" mass="48307" checksum="985E29AA28A3891E" modified="2011-04-05" version="1">MQNGSFRNDTIVAISTPPGRGGIGVVRLSGADARAIALPMLRLKHALEPGRVRLAKIVDPESGEVLDEAVVTLYEAPHSYTTEDVVEIACHSSPVLLEAVLRGCVQAGARLAEPGEFTQRAFLSGRLDLTQAEAVHDLIEATTLHQARIAAAQLGGALSKIVAPIKRRLVELIAGLEAGVDFAEDDLDLMTEAEIAARIESVRDPLQALAATYDYGRIVREGFTLAIVGRPNAGKSSLFNRLLVRQRAIVTDQPGTTRDAISERMSIEGIPVELIDTAGLRTAPDGPEGEAERQGIERTNVAMAEADLVLHVVDGGALTKDIDEIVVAEARPYLRVLNKSDLLSAGVGAEASEGAIRTSALTGEGIEELKRAIVMALTQTATPPESAVLTNVRQHGAIMQAVDALEIAAVAAQDGLPHELLLLDLYGALDALDRLTGATSADEILNLIFSTFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN9</accession>
    <name>E8WWN9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein UCP037205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3784</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582092.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3784"/>
    <dbReference type="EnsemblBacteria" id="ADW70784">
        <property type="protein sequence ID" value="ADW70784"/>
        <property type="gene ID" value="AciX9_3784"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3784"/>
    <dbReference type="eggNOG" id="COG4338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133948_0_0_0"/>
    <dbReference type="OMA" id="CGRTITW"/>
    <dbReference type="OrthoDB" id="1872036at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017136">
        <property type="entry name" value="UCP037205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37463">
        <property type="entry name" value="PTHR37463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10013">
        <property type="entry name" value="DUF2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="15251" checksum="E83E18E4D46830DB" modified="2011-04-05" version="1">MPDKVRKVERVTPHKDKICKTCGRAFSWRKKWEKDWDVVKYCSDGCRGRQVGEADAQLEAAILELLAERGRDKTICPSEAAKFVGGKDERRDWEGLMEPARAAARRLVAAGRINIMQGGKVVDGSTAKGPIRLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU4</accession>
    <name>E8WWU4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0350</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578750.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0350"/>
    <dbReference type="EnsemblBacteria" id="ADW67422">
        <property type="protein sequence ID" value="ADW67422"/>
        <property type="gene ID" value="AciX9_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0350"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_0"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="31714" checksum="831936D945627090" modified="2011-04-05" version="1">MTPKKIRKAVFPAAGLGTRFLPATKATPKEMLCLVDKPLIQYGVEEAVAAGCTEIIIITSRGKTTMEDHFDSNPELEASLAAKNKTALLEIARSVSKLAKITFTRQSQPLGLGHAVLMAKEIVGDEPFAVLLPDDIVDADTPCMKQMVEAFNETQCSILGSEVVEGDAISAYGCLDCSVEPSNPRLLAVKGMVEKPKPGTQPSQNAIIGRYILTPRIFEMIEHITPGAGGELQLTDAIKALLQHEKVYGFSYEGKRHDAGDKQGFLRATVELALKHPQLGPDFRTWLKNFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV0</accession>
    <name>E8WWV0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">AciX9_0356</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578756.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0356"/>
    <dbReference type="EnsemblBacteria" id="ADW67428">
        <property type="protein sequence ID" value="ADW67428"/>
        <property type="gene ID" value="AciX9_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0356"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_0_3_0"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="674"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="851"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136885" checksum="2C5181CC4440019F" modified="2011-04-05" version="1">MILPFVRDLVADLKLSASYDRVRRHLVSGQGRRRVAGLTFTARALYLPLFAAASESPALILVADNKAAEALHQAILATCELTGALDPASIVRLPAHDVLPFESLSPHPEIQETRAASLWKITSKSAKLVIAPIESACLKLFPADFYSALALRLRVNEEYLPDMLVEHLLSVGYTRVDVVEMPGQLTLRGGILDVYSPEMDRPIRIDFFGDEIESIRKFDPETQRSSSQLDTALLLPLTEIPITEKVLEAINARLTRSGSAAAAILEGGDTPAELQTHVSTRTGADATVFPGWEFFAPVAGATKTLLDLLGPQTRVFVEEPSMLKNQGERWWNKVEQRHERSGIGNLIRPEDLYVSPWELDDRIRGFCGAELDQLGAVDVLDADRSDLSEVEFHSRPTMRFHGSIPALIDQLKTLTSPSADNRILLTAPNQGEVERLAGLLQEYGVPYRLGSRNMAPGSETMYSESSYLAGNVSTPVIVRVPIANGVQILDLIPSTARQLIVFGANDLTDEADITARPATRKSKTSAFISDFRDLAVGDYVVHVEHGIAQYCGLRVLEEDTDNPLELMILEFADQAKLYVPLTRLDLIQKYRSTETGPAPVLNKLGNPAWQKTKARVKKAMADMAGELIKLYAQRKAAQGTAFSPDNNLQREFEDAFPFNETDDQLAAIADIKRDMESTQPMDRLLCGDVGYGKTEVAMRAAFKAVQDSKQVAILTPTTVLSFQHFESFKKRFANFPVKVEMLSRFRTAKEKAEIMEQTEQGKVDILIGTHAVLGQKLKFQDLGLLVVDEEQRFGVRHKERLKQMRAAIDVLAMSATPIPRTLHMSLVGLRDMSVIETPPKDRMAIQTIVAKFDEKLVRTAIEMELERGGQSYFVHNRVETIYEMASMIREQVPSARVIVGHGQMPEAELERVMLAFMNHEYDVLVATSIIENGLDIPLANTIIINRADRHGLSELYQLRGRVGRSNRRAYAYLLIPPDTELTEIARRRLAALKEFSDLGAGFKIAALDLELRGAGNMLGGEQSGHIEAIGFEMYTTMLEEAVNKLKGEQDKPSETTVLNLGISVRIDADYIPEENQRLRMYKRIAGALDQATIDDVRSELHDRYGAPPETVLNLLAAGELRLQAERLGIAQLDRKRTQIELPNPANRKQPIKTFVEMLHIRFAIPEKNVLGDTSLASATVDPGLLMKIIARNAKRGAQFTPQGILRWPLTSPKAEEVLAETRALLDSLTPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX01</accession>
    <name>E8WX01_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579881.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1509"/>
    <dbReference type="EnsemblBacteria" id="ADW68562">
        <property type="protein sequence ID" value="ADW68562"/>
        <property type="gene ID" value="AciX9_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1509"/>
    <dbReference type="eggNOG" id="ENOG502Z8F8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062029_0_0_0"/>
    <dbReference type="OMA" id="NIWKVHG"/>
    <dbReference type="OrthoDB" id="503036at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37676" checksum="0B0E44F022D39D39" modified="2011-04-05" version="1">MDISALKLTIQQHMSDGLVTIVGSGLSCAEGIPGMDALASHLCSSMPSLMTGPLVAEWAKVSPNITAYGLEDGLTKIAPSTNLEEAIRSEVGRVVFEAEAAITAEVFAGTRTLGFTRLLPHLLRPAGGIQVVTTNYDRLLEVASEEAGLGVDVMFTGVFAGRLDERETRLSFCRDVKLHKGTSRFLYADRVVISKPHGSLDWYERNGEPVRHCGPLHNVSRLIIPPGQNKYRNGYSSPFDVHRERGNKEIDRASRFLIVGYGFNDGHLETHLTERIRKGIPTLILARTLSDNAKKVVGANPNVIALESAVVSGVKATRVYSQGSTDIFGGMSLWDLEQLVTEVFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX24</accession>
    <name>E8WX24_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1532"/>
    <dbReference type="EnsemblBacteria" id="ADW68585">
        <property type="protein sequence ID" value="ADW68585"/>
        <property type="gene ID" value="AciX9_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1532"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_2_0"/>
    <dbReference type="OMA" id="HAIVQEE"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028351">
        <property type="entry name" value="CyaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001892">
        <property type="entry name" value="CyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="514" mass="55189" checksum="C82A42E55BB95FF6" modified="2011-04-05" version="1">MLGSMAQHDPHDSSLLRGACAVAARGAAAGLALPFLLLTLSTPALSAQAPCAGTAPSPAAAADCTARNTPVATVAPLDPNHTYSLTELIDLAEHNNPRTRIAWEQAKQRANALGVEKSAYFPLLVFQAIGGDQRTISPFPKSLEPQGFNMVEIPIIQPGLNLQYLLFDFGTRSARVDAALADKIVGGANFVQANQEVAFRVATAYYRLLTAQERLQATRETLKTGQTTQDAAEAQLANGRSTIPDVLNAKAETSQDVFDMESADGDEKIARVELVEQVGAEPTPNINIDAMSKAPLPETLTVSIEELIERAVAGRPDLAAQAAEIRAAEDRIKVAKGAYKPRITLTASGAQTSIWPTADYGALGRASEPTWSAILGVEWRVFDGGARRNLLESAQSQKRQAQDEYTERHDRATREVWTAYIAFRTALKKQQAAVALMEAANESYGASLEAYKYGVKNLIDVVTAERQLAQARLSGVSARSQLFLEAVDLEFVTGNLLRSLPPATKLEPKDGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX30</accession>
    <name>E8WX30_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HtrA2 peptidase</fullName>
            <ecNumber evidence="4">3.4.21.108</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1538</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579910.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1538"/>
    <dbReference type="EnsemblBacteria" id="ADW68591">
        <property type="protein sequence ID" value="ADW68591"/>
        <property type="gene ID" value="AciX9_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1538"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_0"/>
    <dbReference type="OMA" id="GPLFNQR"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="348"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="456"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="562" mass="58374" checksum="1811491ADD53DE84" modified="2011-04-05" version="1">MESPMNQGTPKQDFFTKVRAHRLTTTFTLLTTLTVGVMAGSVMTRDVSGKEQQKVDSSDARPIVIPNPVTLSNGFSQIVKQVGPAVVNINTESLPKQALKKPGRGLQRPMPNPHGDQDGQGGNQGDMQDFFNKFFGGQNPGGGGGDDDDAGGGERRALGSGYIVDPRGYIITNNHVVDKADKIFVKLAGDSDSADPGYAARVIGVDTETDIAVIKIDAKEPLPTVGLGNSDGAQVGDWVLAIGSPFGLSQTVSAGIVSAKNRSIDERDAQGLSKQFQRFIQTDAAINPGNSGGPLVDMGGKVIGMNTAIYTQSAGSEGVGFAMPSNIVAKVYNDLISPEHKVIRGSIGIQFQAAQSSAVNRVYGFTSGGVIVGSVTKGGGAEKAGLKPGDILVSIDGRQIKDGDDLVADISARKVGTNVQIGYLRDSKPEKHTASVTIGDRAKVYAALAGAGTEDESAPEESDAGQTKLGITVTALPAPVAQKLGIQGGVTVSNVTPGSFADEIGLAKGTLIVEINKQPVVDDASYRAVVSRLKTGDDVVFVVRDPRASRSSGNSFLGGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX63</accession>
    <name>E8WX63_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2681"/>
    <dbReference type="EnsemblBacteria" id="ADW69705">
        <property type="protein sequence ID" value="ADW69705"/>
        <property type="gene ID" value="AciX9_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2681"/>
    <dbReference type="eggNOG" id="COG2980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114082_0_1_0"/>
    <dbReference type="OMA" id="TGCGYHT"/>
    <dbReference type="OrthoDB" id="1598625at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234126" evidence="2">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="18307" checksum="C8CCD288B5C1AC2F" modified="2011-04-05" version="1">MLFLLVSMVLPLSGCGYHTAGAATHLPASVRTVAVPVFENRTQSFHTEFAFTQAVIRELNTRTKYQVLNTDGPADATLKGTILSQTASPLTYDSTSGQTSSYLVTITARVVLTGSDGKVLYQNDALAYREQYQSTQDLSGFIQEDGPAVRRMARDFAQTLVSNVLESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX89</accession>
    <name>E8WX89_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-selective porin OprB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2707</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2707"/>
    <dbReference type="EnsemblBacteria" id="ADW69731">
        <property type="protein sequence ID" value="ADW69731"/>
        <property type="gene ID" value="AciX9_2707"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2707"/>
    <dbReference type="eggNOG" id="COG3659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629923_0_0_0"/>
    <dbReference type="OMA" id="YALASPW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="456" mass="49352" checksum="D2EAD695008C2DD1" modified="2011-04-05" version="1">MPPTQHGTIDDVGQGMMPFCLTRVLPALLCLGLAAAASGQVGSGAPDASGPAQRLSKSSTATPENAQTDDLSKMRGQALDQDAAVLSTVPPDPLFHRDPLRWGMVPFDATFNGLQRKEGITFAGSYTLLDQYATKTPDGVRHNAGTGRFDLVGGWKAYDHGGNAGSFSMLVRSGTNIGVSEQFNLSNALGSGLVLNCLQGGAAQDTISLNILYYRQDFYKRKFAFYIGKLHPNEFISLSLYNNDERSQFLNAQNDGNLTIASDGTYAGGAALEYQVTQHFYIHTVTVDTEGGEQRNLRSLADKKYMNAVEFGWKSGAPTRQEHLFRLALWRDDTAHLGSGAGAGFGSDYELKSGWVPFGRLGVATDSGTSIKRVFDAGVAHIRPFGRRGDMFGASINITDPSHGAKHHESLFETFYRVRVTRSFEAGPDLEISIHPTNSPNAYVTALLGMRVKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX99</accession>
    <name>E8WX99_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ordered locus">AciX9_2717</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581056.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2717"/>
    <dbReference type="EnsemblBacteria" id="ADW69741">
        <property type="protein sequence ID" value="ADW69741"/>
        <property type="gene ID" value="AciX9_2717"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2717"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_4_0_0"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="117"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="326"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="456" mass="47877" checksum="4E2B158209BB9DFD" modified="2011-04-05" version="1">MKLTLGQVADWIHAEGDFTTSSEAVGYSIDSRTIGAGELFFAVTGDRVDGHDYVEAALANGAVAAVVSNRWLASDEPREVDPCKLLWVPEGEECVLRAMQLLALRVRQSWGGRVIGVTGSAGKTTTKEMVATVLSSQFSVLKSAGNLNNHFGVPLQLLRLEAEHEVAVIEMGMNHSGEIKRLAEIAEPQWGVVSNVAAVHLEFFPAGIAGIAAAKRELIEALPSDGLAILNGDDEWVRGFGVGVDSVLYGLGDEAQVRATNVVEAGLDGVSFTVHAGGDTAEVHLALLGKHNVSNALAAIAVGWKSGMTLTACAAALAEMRATDKRGAVIEWRGAKLLNDSYNSNPKALDAMVDALISTPATRRIVVAGEMLELGPEGPALHKACGRRMAEQGVDLIVGVRGLAADLVSGAGEKAVFVETPEAAGNWLTANVKAGDVVLLKASRGVRLERALEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD9</accession>
    <name>E8WXD9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin, OsmC subfamily</fullName>
            <ecNumber evidence="1">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0400</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578800.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0400"/>
    <dbReference type="EnsemblBacteria" id="ADW67472">
        <property type="protein sequence ID" value="ADW67472"/>
        <property type="gene ID" value="AciX9_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0400"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_1_0_0"/>
    <dbReference type="OMA" id="ANCPVSQ"/>
    <dbReference type="OrthoDB" id="1655733at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="14952" checksum="2D9817004186120B" modified="2011-04-05" version="1">MDRSASAVWQGGLKDGKGTISTQSGTLHEAQYSFSTRFENGVGTNPEELIAAAHAGCFTMALSGQLTSAELTPDSIETTAVVTMEKTDDGPTVTKIHLVTKARVPNADKDKFDELAKKAKEGCPISRLLKAAEITLDAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF7</accession>
    <name>E8WXF7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578818.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A77"/>
    <dbReference type="EnsemblBacteria" id="ADW67490">
        <property type="protein sequence ID" value="ADW67490"/>
        <property type="gene ID" value="AciX9_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0418"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_1_0"/>
    <dbReference type="OMA" id="TIPPYWE"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="397"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="618" mass="68579" checksum="0408C3DEE2137929" modified="2011-04-05" version="1">MSNPLIPPMIPRSVIFDHPQMDHAQLSPNGKMIAYLAPAAGKLSVWVRTIGQADDRVVAQDPRRPIPWAQWQGDGEHVLYLQDSEGDENYHLFRVNLLGGEPQDLTPGSNLRALPLALDYQFPNEGLVTLNARNARLMDVHRLDFAAKSNTLDTENPGDVLLWLADNELRVRAAVAQVADGSFVIRVRDADGSDWRLLDEIPFADGRPRLVAFSPDNQCLYVITAKDADTHRLVQYEVSSGAVTTLFEDPEYDVERVYIEPGTRKIGAVAILREKLVWTALSVSCEAALRSFKELDPGEFSFVAGTGRGDALILQCQGDIIPDKYYLYDLEQHSASLLFHTRPKLLDYTLAAMKPITCTARDGLQLSGYLTLPVGIEPHGLPTVLYVHGGPWHRDRWGFDPVVQWLANRGYAVLQVNFRGSTGYGKAFLNAGNREWAGTMRTDLLDAHDWAIAEGYADPERFAIFGMSYGGYATLTALAWTPDAFCCGIDVVGPSDLTTFMASIPSYWEPMRKLLEERVGDNDDFLKSQSPLYRASAIRAPLLIAQGANDPRVKKRESDQIVDALRESGTEVEYLVYENEGHGLAHQENLHHFAGVAEMFLARHLGGRAEAPPDLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN2</accession>
    <name>E8WXN2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hopanoid-associated sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1595</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579967.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1595"/>
    <dbReference type="EnsemblBacteria" id="ADW68648">
        <property type="protein sequence ID" value="ADW68648"/>
        <property type="gene ID" value="AciX9_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1595"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_0"/>
    <dbReference type="OMA" id="GAYKRSK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017829">
        <property type="entry name" value="Hopanoid-assoc_sugar_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03466">
        <property type="entry name" value="HpnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="36173" checksum="325A099083AE9E97" modified="2011-04-05" version="1">MKVFITGATGFVGAHVARAYAAQGASLRLLTRSSSNLAGIEGLEAETVVGDLRQVEGLRVALTGCDALVHVAADYRLWVRDPEEMMAANVGGTRELLRVAREVGVPKVVYTSSVATMGFLTDGTIVDEATPVSVEAMIGVYKRSKYLAELEAIAAAKAGQHVMILNPTTPIGPGDRKPTPTGGILVDFLNRKFPAYVDTGLNLVDVGEVARMHVVALERGTPGERYILGGENLTLKQILDRLSTITGLPSPTIKVPHAVAMAFAFFDENFTGRLLGKEPRATVEAVRMGKKMMFASSAKAERELGFKVVPVYGAMRAAVEWFLANGYAPALKADVGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV7</accession>
    <name>E8WXV7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2779</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581117.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2779"/>
    <dbReference type="EnsemblBacteria" id="ADW69802">
        <property type="protein sequence ID" value="ADW69802"/>
        <property type="gene ID" value="AciX9_2779"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2779"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_0"/>
    <dbReference type="OMA" id="HGIGYYP"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="33"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="510" mass="56080" checksum="8954C7CC325CF0A8" modified="2011-04-05" version="1">MATAAPVHQITPETYGRKLQLKARYDNFINGQWIAPVAGEYFENVTPVTGEPLCQIARSKAEDVNKAIDAAHAAKGAWGRTSTTVRARILEQIAQRIEDNLEYLATAETWDNGKPIRETMAADLPLCVDHFRYFAGCIRAQEGGISEIDHETIAYHFHEPLGVIGMIIPWNFPLLMATWKLAPALAAGNAVILKPAEQTPMSILLLMELIGDLLPPGVLNVVNGFGLEAGKPLASSPRINKVAFTGETTTGRLIMQYASQNIIPVTLELGGKSPNIFFADVMNEDDAFFDKCLEGFTMFALNQGEVCTCPSRALVQESIYERFMERATARVKAIKGGNPLDSATMIGAQASSEQLEKILSYFDIGKQEGAKILTGGKRSEAGPAGGFYVEPTIFEGHNKMRVFQEEIFGPVVSVTTFRDEDDAMAIANDTLYGLGSGVWTRDINRAYKFGRGIQAGRVWTNCYHLYPAHAAFGGYKQSGIGRENHKMMLDHYQQTKNQLISYSPNAMGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY64</accession>
    <name>E8WY64_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1639</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1639"/>
    <dbReference type="EnsemblBacteria" id="ADW68691">
        <property type="protein sequence ID" value="ADW68691"/>
        <property type="gene ID" value="AciX9_1639"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1639"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="OMA" id="PIGCLHV"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37651" checksum="D2C0662007B85B0A" modified="2011-04-05" version="1">MKAAVLYGKEDLRLEEVAVPVAGPGEIVVRVGAALTCGTDLKVYKRGYHAAMGTPPMLFGHEVAGVVTEIGDGVQWFEVGERVVPMNSAPCDECFFCLKGQQNLCEDLLFNNGAYAEYIRIPARIVEKNTLRVPEGVRLDYAALTEPLACVVRGLEESGARAGDSMVVIGAGPIGLMFMHAAELAGVDVIAVVKREDQVEAAKLFGARQVVRIDEAVDVVEAVRALTPAGRGADIVIEAVAVPETWEWAVEMVRKGGVVNFFGGPPTGTVVALDTNRLHYGDITLKASFHHTPATCRTAFELVSSGRFKCAEYITGAVGLGEVPAVFERMMVRGGVGMDIKTAVYPVSRGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE4</accession>
    <name>E8WYE4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2827"/>
    <dbReference type="EnsemblBacteria" id="ADW69850">
        <property type="protein sequence ID" value="ADW69850"/>
        <property type="gene ID" value="AciX9_2827"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2827"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_2_1_0"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29540" checksum="BDADFAA7C99BFECC" modified="2011-04-05" version="1">MTFLGSGTSMGVPTLGCPCAVCADARIPGSRNRRTRPSLRLEWEGHTVLIDTGPDFHAQAIRENISRVDAVFYTHHHADHILGMDDLRPLSFRNTTPLPLYADDPTADALERVFGYTFRTENRYPTSARVQIHRLDPTPGSTTRIFGANFQRIPVIHGRERITGYRFGSAAYLTDMSDIPPESLALLQGLDILILDALRPAPHPSHSHVAKSIAFVEQLKPKRAYFTHMGHELDHNATEATLPQGIHLAYDGLQLTFDIAPEETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ3</accession>
    <name>E8WYJ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578919.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0519"/>
    <dbReference type="EnsemblBacteria" id="ADW67591">
        <property type="protein sequence ID" value="ADW67591"/>
        <property type="gene ID" value="AciX9_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0519"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="ERPGTEI"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="977"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1060" mass="113192" checksum="87E0E78A9B9F29AE" modified="2011-04-05" version="1">MSDVIHASISERPSGFWLARLSKPIYFFLAVLTIAGIYAAFQVPISVFPDTNFPRVVIGVDNGVMPVEQMQVTITKPIEDAVNSVPGLTTVRSTTSRGSAEISLLFDWNVDMFRTLQLTDSALAKIQSSLPATAKITTNRLTFATFPILGYALTADDRGADTVSQTALWGIATYNLKPQLNRVSGVATVVVQGGKVPEFHIVPDPAKLQTAGVTLLDLVNAVQTSNIIDSPGLYEADHQLILGLVGAQAHDVDQLGNLVVKNTAANVPVRINDVAMLGPATMPVFTSVDANGKPAVLLNITRQPTSNTVAVATAVDAKVQALKSMLPPGVHMTPFYDQSELVRESIASVRDAILIGLVLACLILFLFLRDWTSSLIAGLVIPVTVAITILFLWIIGQSFNLMTLGGLAAAIGLVIDDAIVVVENIVVHRDAGQTRSDAVRLALREIIVPLVGSTVTPVVVFLPLIATTGVTGSFFRALAVTMTASLLTSLMLALTFTPALSLSLLREAGSNKKHGHEENGPVMRRLLATHNRLLSWTIGRTWAIGAIALVLIGSSYFAFNALGTNLLPEMDEGAFILDYIMPAGSSLQATQEVLDHVEHILHETPEVEITTRRTGLQLGLAAVTEANTGDISVRLKAKRSRPIDEIMNEVRDKIKEQYPQLDVEFVQVLEDMINDLSNSPEPIQIKLFSNDTTLLHELGPKVQAAIAAIPGIVDTQNGVDNTLSGPATTFQVDPSVAARLGFTPQEVAEDATSLMDGLPTTDPVIVGGRPYTVRVRMSDEHRASLSAIENTVFNSATGHTATLGALAQVTELPPQNEIRRENLEQVVLVSGRLEGSNLGGAMTQVKAAVAKLSLPASVRVEYGGTYQEQQKSFHDLAQVLVLALALVFGVLLAEFRNFSAPIAILTSSVLSMAGVVFALLTTNTNFNVASFMGLIMVIGIVAKNGILLLDADERARAEGANALDAMLHAAQRRLRPIVMTAVAAMCGMLPLAFAFGAGSQMLQPLAIAVIGGLIISVLLSLVVTPAIYYQLTMRTDCKATAEPQETLALQLIASRCKCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK0</accession>
    <name>E8WYK0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0526</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578926.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0526"/>
    <dbReference type="EnsemblBacteria" id="ADW67598">
        <property type="protein sequence ID" value="ADW67598"/>
        <property type="gene ID" value="AciX9_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0526"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230073" evidence="1">
        <location>
            <begin position="39"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="40385" checksum="79CBC24655C8BD15" modified="2011-04-05" version="1">MPRALSVFVTPASFSKTTLRLAGCAASVLLMLSAAAQAQTDITQLPYTSKHVTVPADRPYTVAPNTAFVAGNDVLIPLFDKLDKRWAEVEPDVHFKKIMMGSTLSVEGLVSEKSAFGPIGRGNRRPEEDYFTQRFGYAPTYLKIGYDSNPNNKLSTGIWVNASNPIKSITLAQAAAIFTTGSGTGDITHWSQLGVEGEFGEVPIHPYVTRDTSAILAMIDEMRDKFGGRPFTSQVEWLPTEEAAINSVAQDAFGMVLMDYWNNVAVMKGVTTWKHLPDFGPRIKFVPMAYEAGGTLSDGTLTGPLHPMASAIGININRVPGKPLDPWLKAYCEFLLSKDVQDIIGSPEMRKVGFRPLQPGEAAEELKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR4</accession>
    <name>E8WYR4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1701</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580069.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1701"/>
    <dbReference type="EnsemblBacteria" id="ADW68750">
        <property type="protein sequence ID" value="ADW68750"/>
        <property type="gene ID" value="AciX9_1701"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1701"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="50"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="423"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="456"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="669" mass="74846" checksum="04C74BA8C1DDB394" modified="2011-04-05" version="1">MPTDKKAAEKAKQKTPEKKPADDDAVGKIYDSRLAARLFRYLSPYKLQVAISAFSILIKAGSDVAGPFLIKVAVDTYMTQTPHEKLGWLGRHLSPNPMTGITEAAGLYFLALLLSFGLEFIQTYLMQWTGQKIMFDLRSQIFRHIQTQDTGFFDKNPVGRLVTRVTSDVDALNEMFTSGVLAIFEDVFVLLFIVIIMLSMNWALALLTLTVIPAILYVTSVFRKHVRESYRRQRGATAQINSFTQEYVSGMSIVQLFNRERRALTDFNDANDRNKQAWTDAIFAYALYYPIVEFLSYLAISLVLWRGGIGVMQAVGIDPHLIQSRLGGTVTIGILVAFIQYAQRFFRPIQDLSDKYNILQAAMAAAERVFKLLDENPSIVSPAQITVPDPSDGTYGRIEFKNVWFTYEQLGDEDKLFLARTTPGSDDIAKHVGHVEWILKGVSFTINPNETAAIVGHTGAGKTTITGLMMRFYDIQHGQILIDGVDVRQHDLKALRQRFGVVLQDPFLFSGTIAQNIRLGTPWITEAQVERAADEVNVGDFIRTLPLAFAEPVRERGAGLSTGQKQLVSFARALAHAPGILILDEATSSVDTETEHLIRTALARMITGRTSVLIAHRLSTIQSADTILVMHKGQLREQGTHQQLLAHHGLYYKLYQLQYQDQEQLPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS4</accession>
    <name>E8WYS4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1712</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580079.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1712"/>
    <dbReference type="EnsemblBacteria" id="ADW68760">
        <property type="protein sequence ID" value="ADW68760"/>
        <property type="gene ID" value="AciX9_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1712"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="OMA" id="DAMYNSL"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24613" checksum="7E3397123209D8CE" modified="2011-04-05" version="1">MRIKFQQNLDDLKEKLLTMAGLAEQAIQRSIEAYRTRDLTICELVFKAEPAINRLEREIDQMALDLLAMEQPMAVDLRFILSVIRINADLERVGDQAVNIAIRVKEMGAFANIDLPVDIPKLASLASAMVRKALQAFIEGDAELAQSVLQLDDQVDEMNDAAFYSLSSLIKERPELTPQSLNALIISRNLERVGDHATNIAEDVIFWVRGADVRHNSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV2</accession>
    <name>E8WYV2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1740</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580107.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1740"/>
    <dbReference type="EnsemblBacteria" id="ADW68788">
        <property type="protein sequence ID" value="ADW68788"/>
        <property type="gene ID" value="AciX9_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1740"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_3_3_0"/>
    <dbReference type="OMA" id="KYPNECI"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234176" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="323"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="402" mass="44718" checksum="EF3BFD3F4DB9C951" modified="2011-04-05" version="1">MRPFLRTITSLLLFAPLLPMHAQQTAKLAATPPMGWNSWNWFAGKVTDKDVRQAADLLVSSGMRDAGYVYVNIDDTWEGKRDSTGVLHTNEKFPDMKALADYVHSKGLKLGIYSSPGSQTCARFEGSFGHEQQDADLYASWGIDYLKYDLCSFHNGNMRVTAPGDSAEAMTIQYKMMHDAYARMHQALLKTGRPIVYSLCQYGFDSVWQWGPEVGANLWRTTDDVNATFNSIALIGRDQAGLSRYAGPGHWNDPDMLEVGNGKLTLDENRTHMGLWSMLAAPLLAGNNLSELTPEITAILTNREILAIDQDKLGHQADRIYAEGPIEIWARPLADGSRALAIFNFGEQRSYLRGISLHLREAGAADGWHARDIWAAKDLGPITDKMPLTIPRHGSIVLRLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY3</accession>
    <name>E8WYY3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase, hydantoinase/carbamoylase family</fullName>
            <ecNumber evidence="3">3.5.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2875</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.87" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581213.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2875"/>
    <dbReference type="EnsemblBacteria" id="ADW69898">
        <property type="protein sequence ID" value="ADW69898"/>
        <property type="gene ID" value="AciX9_2875"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2875"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_6_0_0"/>
    <dbReference type="OMA" id="CLGQKWF"/>
    <dbReference type="OrthoDB" id="829830at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050538">
        <property type="term" value="F:N-carbamoyl-L-amino-acid hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="423" mass="44374" checksum="41F7D4601712585F" modified="2011-04-05" version="1">MSAHVDGARVQRELEELARFTHVEPSSEGTAVTRVVFTDDDLAARTWLIGLAEAEGFAVRVDAVGNTFIRLEGADPSLAAVATGSHIDAIPHAGMYDGTVGVIGGLEALRAIKTSGVQPKRAVELILFTSEEPTRFGIGCLGSRLMAGTLSDVKAGGLIDLTAAKGEAAKTLDEVRTAAGFTGALTSTRLLPGHYAEFVELHIEQGPLLERDGQDVGIVTSIAAPASYRFVIEGFGGHAGALLMPDRRDALCAASEVILAVERSALTLGTIDTVATVGTCGVYPGAVNSVPSKVALELDLRDTDPRRRGRVMDAIRSEIAAIETKRGVRITETLVNEDVPAACGERIVGAISGAAVAAGMSSRMMVSRAYHDTLFMAQICPVGMIFIPCRGGVSHRPDEFATVEGISHGTQLLTEVLTVLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ36</accession>
    <name>E8WZ36_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ordered locus">AciX9_2928</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581266.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2928"/>
    <dbReference type="EnsemblBacteria" id="ADW69951">
        <property type="protein sequence ID" value="ADW69951"/>
        <property type="gene ID" value="AciX9_2928"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2928"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_0"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="23970" checksum="D6C107863EAE8D62" modified="2011-04-05" version="1">MARYTGPVCRMCRRDGVKLFLKGSKCFTEKCPVEKRNFPPGQHGQSRKVKKVVGYGLQLREKQKAKRIYFTLETQFRAYYQKAANKTGVTGDLLLQQLETRLDNVCYRLGLATSRRQARQVVRHGHIQVNGRKVNIPSFQCKVGDEIAVREGSKTLSFFETAKDFAGGLQSVTWLDINRDTLSGKVVMLPKREDVQLPVNEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ75</accession>
    <name>E8WZ75_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0606</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0606"/>
    <dbReference type="EnsemblBacteria" id="ADW67677">
        <property type="protein sequence ID" value="ADW67677"/>
        <property type="gene ID" value="AciX9_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0606"/>
    <dbReference type="eggNOG" id="ENOG5033UHJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801146_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="37577" checksum="3893F569C49977C9" modified="2011-04-05" version="1">MLGAVAIIVALGRGVGGTIFIDKRSWLIFYPPMRKQQNRRFGSFHASRLVAFSICGAAGLTGCSVTPLAAHTAAFAKATTVVVNSSEDAYRKANSLYFEEQTSAAVLKYDSSPTWDPHSIKPLLTDQQLKVRYTLLDGLKEYAKNLDTVENAPKNMKGLGTASEGLGTNLMTLSTDANSVLAGGGISGLSLTQAQANNVSTAAYALGEFLAYRKVKGRLPQEIVSMDPAIDTLCKVLVTDIAKLEQQADNDYSMLLTQEDVFIRTSHGMTPMERRTEIARLPRILQRQKTTHELMDELTKAIQSLALTHHALASAAQGHNPEALKARIADLEAIGSSLATYYSSLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ2</accession>
    <name>E8WZJ2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ordered locus">AciX9_2943</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2943"/>
    <dbReference type="EnsemblBacteria" id="ADW69966">
        <property type="protein sequence ID" value="ADW69966"/>
        <property type="gene ID" value="AciX9_2943"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2943"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_0"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21768" checksum="8D7DD0825A02037D" modified="2011-04-05" version="1">MAPRNRGEREVNIMASRFRTKYETEIKDSLKKELAIENPMAIPKLEKIVINMGLGEATQNVKIMDPLVADLAAIAGQKPVTTRAKKSIAQFKLREGMPIGAMVTLRGDKMYEFLDRLITIALPRVRDFRGVSSKSFDGRGNYTLGLRDQLIFPEIDYAKVDKMKGMNVTIVTTSLDDNGARTLLKAFGMPFRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP7</accession>
    <name>E8WZP7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2998</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581335.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2998"/>
    <dbReference type="EnsemblBacteria" id="ADW70021">
        <property type="protein sequence ID" value="ADW70021"/>
        <property type="gene ID" value="AciX9_2998"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2998"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873715_0_0_0"/>
    <dbReference type="OMA" id="QGLPKCP"/>
    <dbReference type="OrthoDB" id="1309918at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230111" evidence="2">
        <location>
            <begin position="18"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="37267" checksum="B468BF40C77D7C57" modified="2011-04-05" version="1">MRSLALALLLIPAALLAQKKPRDNKDNLSGYDRSARATVLHDAVVYVAADDSTQKVAEVTPGHELVIIDHSGPWVKVYANTDTPDEADPDRTPEFAEDDTVTPASGWIKDKGVVNAATPNGDAILFGAATNLEEAASQPHAPKNAAPGAHLLYRRVFEYFPNSPLAAEAAFRSADIRWQLEKLDISTLPSAKEQEAYLRPQLYEGEMKHIMKTYPGTKFAAEAAYDLLDNKLCGDWQGLPKCPEMETKLYLKYADQYPESPRAPEAEYNAVYRQGVAVTMYKVDEDRKHAEAAAKQTQTLADEMRTRFPNSDYTRRAQSIAFRIAQGLSIYGSDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV5</accession>
    <name>E8WZV5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0696</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579094.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0696"/>
    <dbReference type="EnsemblBacteria" id="ADW67766">
        <property type="protein sequence ID" value="ADW67766"/>
        <property type="gene ID" value="AciX9_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0696"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_0"/>
    <dbReference type="OMA" id="SSTRKMD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="481" mass="53838" checksum="D8957BA6E7B1776D" modified="2011-04-05" version="1">MKRQANRKVTVILLSVAILIVALNARFAFVSVKELLQSEYWVQHTWQVINQVERIMGSAKDAESGARGFVITGKEQNLEFYNSAQVELPQELKTFSSLTGDNPSQQARITEMQAVLEQRMATLAEVIELRRANDVESTHAFIQNGTGRIQMDHLRAIADQMEQEEQRLLVIRTATATSSSHRALFSIALASGLDMLLIVLMFRYFAHERSLRIATEEAADRLAIAHAETEARAEEIRQLNATLEERVRQRTAELESTNRELEAFSYSVSHDLRSPLRTIDGFSLALEEDYANEVDATGRDYIRRVRSGVQRMGQLIDALLQLSRITRAEISREDVNVSAIARSIVADIQEADLAQKVSGHGVLFTVQDGLTADADPKLLQVALENLLGNAVKFSSKVEHPSVQFGWDEGQKAYFVRDNGAGFDMYYADKLFNAFNRLHGDKDFKGSGIGLATVARVVRRHHGRIWADSAVDHGATFFFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX4</accession>
    <name>E8WZX4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0715</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579111.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67785">
        <property type="protein sequence ID" value="ADW67785"/>
        <property type="gene ID" value="AciX9_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0715"/>
    <dbReference type="eggNOG" id="ENOG5033BRU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179944_0_0_0"/>
    <dbReference type="OMA" id="WWLQRHR"/>
    <dbReference type="OrthoDB" id="2085931at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9814" checksum="6274602F413188BB" modified="2011-04-05" version="1">MVRILKWVLMGLVVAAAVVYIGDWVVWKARGGPLGSVTVSRFVVASLKGNKEEYYPDGRADVDCSKSLFPQAGAGSCWWVEGHRVVFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY4</accession>
    <name>E8WZY4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1833"/>
    <dbReference type="EnsemblBacteria" id="ADW68880">
        <property type="protein sequence ID" value="ADW68880"/>
        <property type="gene ID" value="AciX9_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1833"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="WANSINP"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1277" mass="138017" checksum="B151AF0FBCC0225C" modified="2011-04-05" version="1">MPHEISPTRISQDDINPAEAVIKKQSNFWRSEVRNYLGVFKYVAAVVLLYCGVVSAFSQTNQGVIAGNVLDSTGAAMPNVTITAKSEETGSSYETKSTSAGSYRFPSIQLGRYTITTSSPGFRPSANTGVEVRVGTVTSLDINISAGGANETITVAADSPQVETQSSDVGGTVTTQQIIELPLALGGVGNLRSPEAFVFLIPGTAGPGTGNSPNGIFISKIGGGQNFGNEVLLDGASQTRSENGSSFDEEAPSVEAISEFKVTTSTPSAEFGRTSGGIENFVTKQGTNKIHGSAFDIFRNEDLNANGWFNNGFKAFYQSQGNPIEGTYNRGNDKQNDYGGSIGGPAVIPHLYNGKDKTFFFFSWEQYRHTLGGAITSTVLTTPERGGDFSDQLGSQKLDAAGNPILNPCDGTPLYNGEIFDPLTTRTVGGVPCRTAFASGGKLNVIPAGRISPLTSKLLAYYPTPTSPGISNNYTLNTSSPISNTTYTIRVDHSLGPHDKLFGSYSTRQNTHNSPTNFQLPSPVTPNVQTQNFITHFGRGGWDHIFTPSLLNHLNLGYNRSNSINGSIESGTGINYAQQLGIPNIVGGFPVINVTGYVSLSRNQNDDNIDNGIRFNDSVSWQKGRNSFKFGVDYRYQQYSSIAHDQENGYFNFNGNQTKAAKLSPYQDGTGLGGASFFLGAFDSAGATINTHQPRWISNYWAGFIQDDFKVSKELVLNIGIRYDIDQPRRESVNDTSNFSPTAIDPHSGLPGALVFGTTCNCNTRWADTWYKDIAPRVGFAYSPSSWNNKLSVRAGFATLYAPLQYSDFGGSETAGFSLPIQQNSDGFTNAYSIDNGLNPYAIKPNLDPGLFSNGNSAAPANFSNYIKPSYGRPAQVNQWNLQVQQEVAKDLIATIGYIGSAGSHLKSGIENVNNIPTSAFGLGDILNRPFSTYAPVSGVKSPYATFNTNANYYQALRPFPQYDFIATDCCLQNVGHSSYEAMIATLERRFSQGLNLQASYTWAKSITNADSALPGTNAGVNQEQDPANPKSIKALSIQDIPHTFVVSYIYELPFGKGKAFGNFSSPFLRSAVSGFKIGAVQRYQSGQPTSFGCADGIPGFQNCIAFSRVPGSSLKSPAFNHIDPFRQLRANYPNVGSDPNVDSEFNGLTNTGNAAYSQFQKAPAIYSQNNSINRSARAVQSGNCATCDNGAFQFGNIPRVTAELRNYKYLNEDFSFLKETPFGEGSSFILKIELLNAFNRHVFGTPDTQPYDYTFGVPTYTINGPRQMQITGRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X013</accession>
    <name>E8X013_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1863</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1863"/>
    <dbReference type="EnsemblBacteria" id="ADW68909">
        <property type="protein sequence ID" value="ADW68909"/>
        <property type="gene ID" value="AciX9_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1863"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_2_0"/>
    <dbReference type="OMA" id="KDIWTSP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="116"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="258"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="437" mass="47755" checksum="453A402539D623B4" modified="2011-04-05" version="1">MQTLDPIPAPTAAYYQKDEDPLPATKVRIAYLLSQYPAVSHTFFLQEVLGLRRRGLHIETASINKPDRPVESLAPEEAIEAKGTRYIKSGQALQIARALLETTFFQPLVVVRGLGAVFSIKGLPLRKRAFWLLYLAEAILLGRWMNRRRLTHLHVHFGGPVASVGMLASIAWKIPYSLTIHGPEELLSVDAYHLREKIAQAAFVMCISDFCRSQLCQLTEPKDWAKFTVNRLGVDPVMLAPSSRPVETPARRQESALELVCTGRLVAAKGHHILIEALALLQERGVTLHTTLIGAGPQRESLEALVAVRGLGENVVFTSALSHAATLEYVRRADIFTLASFAEGIPVALMEAMSLGVPCVSTTIAGIPELIRSGQDGLLVAPANVGALADALEALALDPALRKQLGSSGRQRIVADYNLPLNQQMLAECFEKKLLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X056</accession>
    <name>E8X056_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver and Hpt phospho transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3016</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581351.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3016"/>
    <dbReference type="EnsemblBacteria" id="ADW70037">
        <property type="protein sequence ID" value="ADW70037"/>
        <property type="gene ID" value="AciX9_3016"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3016"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160650_0_0_0"/>
    <dbReference type="OMA" id="CAMDATE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="4">
        <location>
            <begin position="147"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="239" mass="25519" checksum="335480A3CBFC9A92" modified="2011-04-05" version="1">MHEVLIVDDDEVSRELLVLFATEAGFHALALESGDAALDLLQGGEVNPDAILADMRMEGTHGNALAVKLRGMCGDATKVIAMSGSRVSVDETAAFDGFLLKPFGVEELKTMLTMESPQVLHTEHEAGMEKNYALSEATYGTLAASMPREQLLQLYAMCLDDADRRAEAMKELAVAGDGEAYSKAAHAIKGGCGFVGALELASMASAMEEDGPPSDGNVRTLEQFLMASARLRRILNAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X073</accession>
    <name>E8X073_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3034</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581368.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3034"/>
    <dbReference type="EnsemblBacteria" id="ADW70054">
        <property type="protein sequence ID" value="ADW70054"/>
        <property type="gene ID" value="AciX9_3034"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3034"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266178_0_0_0"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="3">
        <location>
            <begin position="860"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1344" mass="134901" checksum="1E1EA8996A054014" modified="2011-04-05" version="1">MGERNGVANDKLPESVRKALILMFYFSARSFVSTVFRAVLLMGLSLCAAGSAAGQTQQFVQPTVIGTGSWPVSLVSGDIEDTGRDNLAYCDAVVPGVTPACHLLRGNSDGTYTKHADYPVPYMTGSRALVGSSIAGGKTTHSLVLVSTVSSPSTTLGQLQVSLYPEGSSLGTTPLIITQVMQMPILGGATMRGPSGVNTGGQEDVAFTDSANGYLYTCHLSGLFSYQRFPLPNGAGNVQAADLNGDGVNDLMVAGADGISLYVLMSDATGQLKAPALLQPPHGARSFLLKDLNGDGRIDLVVEGTNGEIDIYPGAGDGTFGTTSIIGSGASDGTTGHGGHLIAAANVDGDGVLDLLTVTPAGLSVLKGQPGLSYTLDGIYNIGPGHASFAVQDFGSGYVNLLVDSPEGIAVVYGNSSGTFGTSSSFATGQPAMSGATGVFMASGNVDAVVAVNSTQAQLLRGAGDGTFTLAASPTTTLKPGAGSWGSVVVGDFNNDGVLDLTVTADGPSTSPVGLGIGVAVQFGQGDGTFKTASAVASHANGGTAPYFGTSFAAPRLGSGGVPGFVNLDAGNLWTLSTPSLANSVPFATLIAPVSDAHAHSLVTAGVLRAGMAADVVAQDEGSLKVYLNSGTGIASTPLGDLAVDGSLTTTGQMVAPDISGTFPGMSKALGFRAFPGSAVIADLDGDGNGDLIVVYDNLDADHRNPTAANPNYVYVWFGSGGGRFLTSAEHPVNPVRLTPTRNYYQVAVADLNGDGHADLILSDGYLISVQYGKGDGTFGAEQHFLAGQGLNTISVADLRHLGRADLVVANGGSVYGNVVANKETLTPNADVNTGGITVLLNQIQPQVQAISGSVTAAPEPANFEAAYSVTATLVVPAGGPAPTGTVTFTSDNDSVNGAAPVTLALGSAAVTNGAATVSIPAYVATTSTIGPMLPGTRALTAVYSGDANYASATLTGTHVVKLGQTTVSLDLTTPLQVYYGQPIDGIVEITPQDPSYNASGSYSVLSNGVLVPGCVDLKGVSCPYGNPDLLDAGNYTLTIAYNGGPANGDPVNGSGLSGPYPFVVLKDLTTGTLTSSLNPATVGTAVTFSAAIVGNVAVPTGNVTFYDGAVAIGTGALNAGVATLTTSSLAVGLHTVTAAYPGTNDFNPVTIGAVAELIVAAVVPPPPPAGPQSFTLTVTPVPVTVGTGRTAVLLVTVTAVNGFAQPVQLSCAGMPFEAACLFIQGTIPVGGGSTTLDVTTMAPHNCGDPGRLGSLGRTGGPLVASLFGGLGLLLLPKRRKRWMRALILVAMLSGVAALGGCGGNCTDLGTRPGNYSFTVSGVAQGGPITQTASQTVKMAVFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X092</accession>
    <name>E8X092_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3053</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581387.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3053"/>
    <dbReference type="EnsemblBacteria" id="ADW70073">
        <property type="protein sequence ID" value="ADW70073"/>
        <property type="gene ID" value="AciX9_3053"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3053"/>
    <dbReference type="eggNOG" id="ENOG502ZBBH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063401_0_0_0"/>
    <dbReference type="OMA" id="GWRVNYE"/>
    <dbReference type="OrthoDB" id="994564at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="45297" checksum="5F086FC957CCC39D" modified="2011-04-05" version="1">MHVLACILGIFFCNGVVLDAFQTIILPRRPSGRFRITRLFYIVTWGPLTAIAARVRDRRVREQIYSIYGPVSLILLLGLWAVILITGFALIYFAAGTPFHDAVLLTHATDLARLRDDLYVSGTTLFTLGMGDVIPLTHLARVVVVLESGTGLGFVALVIGYLPVIYQAFSRREVSVAMLDGRAGSPPTATELLRRHGFEGGQEELITLLEEWERWAAEILESHISYPILCYYRSQHDNQSWLSALVAILDACALLITTIDGPTTRQAQLTFAMARHALIDLGHVFHVEGKLAPESEITDERLPAEVFDRLCDALGEMQMRLCGDPATMRRLTAIRAMYEPHALALSNYLCMPLPLWIAEPKAGDAWKKVADLRMKQSTPTPIDPLNAQRHVSSNSTALNLHDEEHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C5</accession>
    <name>E8X0C5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvPA</name>
        <name evidence="5" type="ordered locus">AciX9_3086</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581420.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3086"/>
    <dbReference type="EnsemblBacteria" id="ADW70106">
        <property type="protein sequence ID" value="ADW70106"/>
        <property type="gene ID" value="AciX9_3086"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3086"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_0"/>
    <dbReference type="OMA" id="MYDGASA"/>
    <dbReference type="OrthoDB" id="870147at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="49152" checksum="B57BCFA205968034" modified="2011-04-05" version="1">MRYLPKSPTDREEMLADIGVPNIDALFSSIPAEYQLTRDLDVPRQHAESEIIDRFRAYADNNANGYASFLGAGVYKHYKPVIIDSLVQRGEFLTSYTPYQPEIAQGTLQAMFEFQTMICELTGMEIANASMYDGSTGAAEAIMMAVRVTGRNAAVIARTVHPEYREVIQTYATHQEIPLTEVSYASNGRVDMAALEAAITPDTACVLIQSPNFFGTIEDVAAIAELAHSKGALLIVSIAEAVSLGIVRPPAEADIVSLEAQSFGVALGYGGPYCGVIACKEKFLRQMPGRLIGETKDANGKRGYVLTLSTREQHIRREKATSNICTNQALVALMTTIYLTIYGKEGMKELGEHNLAKADYLRSVLSDKGKVLFDGAPRFHEFVLDLKQGAEAANVALLEKKIIGGLPLEKWYPELGPGASLWCATEVTKRTDMDAAAEALITIDEPALAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F7</accession>
    <name>E8X0F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0751</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579147.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0751"/>
    <dbReference type="EnsemblBacteria" id="ADW67821">
        <property type="protein sequence ID" value="ADW67821"/>
        <property type="gene ID" value="AciX9_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0751"/>
    <dbReference type="HOGENOM" id="CLU_2806439_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7524" checksum="3B165F9B5600D61D" modified="2011-04-05" version="1">MTTPDSLDTDVIQDRILRLQASLESGDLKLEQVYKDLIAISQEMLFVAEDLESRRINSIVPGANVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X121</accession>
    <name>E8X121_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0819</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579212.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0819"/>
    <dbReference type="EnsemblBacteria" id="ADW67887">
        <property type="protein sequence ID" value="ADW67887"/>
        <property type="gene ID" value="AciX9_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0819"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_0_2_0"/>
    <dbReference type="OMA" id="MNFHHTL"/>
    <dbReference type="OrthoDB" id="1717935at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="24764" checksum="9602B8D3685FDB0F" modified="2011-04-05" version="1">MPPVPSHHHHEHHFQSTETVRDIVIGLSDGLTVPFALAAGLSGALSNAHLVVLAGLAEIAAGSIAMGLGGYLAARGDAEHYASELRREQDEVVTRPEDEAEEIYEIFARYGVSRPAATPVLEALQQNPTAYVDFMMRFELGLEEPAANRAHLSAATIAASYIAGGIIPLLPYMLLSDNAAALRLSVVITLLALAIFGAIKGRLLGTGTLRSALQTTLIGGAAAAAAYALARLLNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X158</accession>
    <name>E8X158_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0856</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579249.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0856"/>
    <dbReference type="EnsemblBacteria" id="ADW67924">
        <property type="protein sequence ID" value="ADW67924"/>
        <property type="gene ID" value="AciX9_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0856"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_0"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="396" mass="43157" checksum="8C9E075A9F03A745" modified="2011-04-05" version="1">MFWVAFSALVCAAIPAGLFCWNLRLYRAPSGGDEGRQPVSVLIPARNEAGGIEAGVRAVLASTGCEFEVVVMDDGSTDGTAEIVGRLAEEDARVRLERAPLLPAGWNGKQHACWVLAQVAKNPMLCFVDADVRVEPGCVGRMAGFLEAGGNGLVSGFPRQVTETTLEWLLLPMIHFVLLGFLPLGKMRAGTDPAFAAGCGQFMMARREDYFACGGHAGIRLTMHDGLRLPRLFREAGFRTDLADLTELAECRMYRTAGEVWRGLAKNATEGLGDPRRIGPVSLALVLGQVLPFVLMALLPGVVLGHAMEYYQQPRPLAWTAQLPAMFWAEFVVVALAIVAAWLPRWIAVGRFRQDWRGALLHPVGIVLLLCVQWYALARKVRGGAVSWRDRAYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B8</accession>
    <name>E8X1B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2027</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2027"/>
    <dbReference type="EnsemblBacteria" id="ADW69072">
        <property type="protein sequence ID" value="ADW69072"/>
        <property type="gene ID" value="AciX9_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2027"/>
    <dbReference type="HOGENOM" id="CLU_2508073_0_0_0"/>
    <dbReference type="OMA" id="MITHGEL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9488" checksum="552D85F81299EB3F" modified="2011-04-05" version="1">MPEVLSLPVFPAYVVGSLSPAPQKLLYDRKSAAYVLSISTRSLDWLVSQKQLATRRLGKKVMITHGELVRFARADHFHLTQAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G7</accession>
    <name>E8X1G7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3191</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3191"/>
    <dbReference type="EnsemblBacteria" id="ADW70202">
        <property type="protein sequence ID" value="ADW70202"/>
        <property type="gene ID" value="AciX9_3191"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3191"/>
    <dbReference type="eggNOG" id="ENOG5033VZV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139085_0_0_0"/>
    <dbReference type="OMA" id="QFAHHRP"/>
    <dbReference type="OrthoDB" id="1942599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233584" evidence="2">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="12874" checksum="68E488A6DC1D475A" modified="2011-04-05" version="1">MPISIQRQFAHHRPTLTRFNNLVLRALRSAAPFFLTLFVVSAAHAQGTMDFSGAQTLMGTFKTFAMYAGAVICLGGLIFAGIRMMSGRFQDAIPGLFGALFGAGVLGWGAGWIGSLTGQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1X5</accession>
    <name>E8X1X5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ordered locus">AciX9_2092</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580452.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2092"/>
    <dbReference type="EnsemblBacteria" id="ADW69136">
        <property type="protein sequence ID" value="ADW69136"/>
        <property type="gene ID" value="AciX9_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2092"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088964_0_0_0"/>
    <dbReference type="OMA" id="AGITFKY"/>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22352" checksum="2355CD21D0BBF864" modified="2011-04-05" version="1">MPTLLHLDSSPAGDASISRHLTAQFVAKWQAANPTGTVITRDITTMQIPPVSQAWIAARMTPADARTTEQKELLTLSDSLIADLKSADEYVFGVPMYNFGIPAILKLWIDQIARPGETFSYVNGTPAGLLTDKKATFVIASGGDYSPETAMASYNYTAPYLKAVFGFLGVTDTLLINAGGAMAVAFGKIDLPTFMQPHIESIHQRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X208</accession>
    <name>E8X208_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580485.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2125"/>
    <dbReference type="EnsemblBacteria" id="ADW69169">
        <property type="protein sequence ID" value="ADW69169"/>
        <property type="gene ID" value="AciX9_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2125"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347750_0_0_0"/>
    <dbReference type="OMA" id="DRIGEWS"/>
    <dbReference type="OrthoDB" id="98528at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234094" evidence="1">
        <location>
            <begin position="22"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="951" mass="102086" checksum="FB09FAA618952B26" modified="2011-04-05" version="1">MTLGRRTRSLALLLVPSLAFAQQNPQAKDPANLMGERTSAPAHADTLEINHGAPALEQLLKKLRTRASLMMIVAHPDDEDGGMLTYESRGQGARVAMLTLTRGEGGQNLMSADFNDALGLIRTQELLAADRYLGVDQMFGTEVDFGFSKTKEETLAQWTHERVLYDAVRAVRLYRPLVLASVFVGGPTDGHGHHQTSGEICQEVFTAAADPKVFPEMGLPPWAPLKVYARVPFSRVTKDGMFDYATGRTIPPLFHNYVTNTDSTGEPVATVEIPEGEKSTLLGMHGDSYVQFARKGLALQKTQIGEGVRTAPAGALSSGYSLKASRTGSSSAQEKSFFDGVDTTLTGIANLAPAAPASLRTTLASIDKQVADAESIFTPENIELTAPPLRDALRSLDTLLAEMKAASLPEEQKYDLLHELRTKRVQLNQALVLAHHLSVSATLADPKAGPEVLSTLTSLAVKIKLDNKSANSYRIAGIHLTANTAGQGIGQADLGAIQPRTTRELPIRLPYLAGLVPTRPYFSRPNLEQPFYNVKDANLRNAPATPYPISAGVQFDDQGVRLDLETVVQATDDAKGPQPVVIVPPVTVSLSSASGIVPLDMPSFPLETRLRVNATDPAACHPVAKDLPKQVAKLSIRLSNDWLVAPGIQDFDPHCAVDKSYAFTISPPHRPEDGTIVKAQAVARSAAYNYTESFRAVGYAGLTPTNFYTPAIDKVTAVDVKTAPNLKVAYLPGTGDSVAEFLPDLGITPTMLTVADLTAQKLASFDAVILGVRAYSAHPELAGAGSKPLLDFAANGGIVLVQYNSGGSSGHAAPYPFDLPGDSAHNVVVEAQPVTFLAPESPALNWPNKLTSADFEHWVEEWGHGFASTWDSHYEALLEVHDPDQDPQKGGLLLARTGKGAYIYCALALYRSLPEGVPGAYRLLANLLSLRQNPGFVTDIKPSEAKQNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X211</accession>
    <name>E8X211_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">AciX9_2128</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580488.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2128"/>
    <dbReference type="EnsemblBacteria" id="ADW69172">
        <property type="protein sequence ID" value="ADW69172"/>
        <property type="gene ID" value="AciX9_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2128"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_0_0_0"/>
    <dbReference type="OMA" id="YMANLGC"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04862">
        <property type="entry name" value="PaeLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014143">
        <property type="entry name" value="NHEJ_ligase_prk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033651">
        <property type="entry name" value="PaeLigD_Pol-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02776">
        <property type="entry name" value="NHEJ_ligase_prk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="370"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="574"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW69172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="914" mass="101209" checksum="335973082CF21497" modified="2011-04-05" version="1">MPAAKKTATKKIAAKKSVAKKSAKKAVKSKASPSDAVDEQLARYRSMRDFDVTAEPSGKAQEITRESLPFCIQKHAASHLHYDFRLGWNGVLKSWACAKGPSYNVKDKRLAVQVEDHPIEYGGFEGIIPAGQYGGGTVMLWDQGTWEPQPGHTDVDAGLRDGNLKFIMHGTKMKGKWALIRMGGHAATEKKPNWLLIKEHDDFERGPDDEAITDSEPKSVITGRTLEEIAKNEDHVWNSKETAKPGQAWYRNDVEADKPVKTAALDLGSLPEEHQPTFLKPQLAQETQTPPSADGWLHELKLDGYRMQARKDGKKVQMLTRSGLDWTDRVKAVAAEVARLPYDAVTLDGEVVVVAENGTTNFADLQASFQEGAKNPLTYFCFDLLHLNGHNPRGLSLLERKKLLAEVLTTADRSTLQFSEHLETSGEEMFHKACELHAEGIVSKKATAPYTEGRNGNWLKSKCLHEQEFVVGGYTLPSKGGSGIGALLLGYYDDKARFIYAGRTGTGFTQKGSVIIRKRLEPIEAASSPFNNPSADARRGAIWTRPSMVVQVRFATWTADDQLRQAAFLGIREDKPASEVRRETAAPTPKSAKSATQPTAASHTTKPRVAAKLIAAPTMEKAPVRLTHPDKVVDNETHLTKQQLADFYWAVSERMLPHIANRPLSLVRCPEGSEKPCFFQKHTNHMLPPGIGSIDVPDKKTGTPEPYITLDTREALAGLAQMGCLEVHPWGSCNDDLERADQLTIDLDPDELLPWEVLTGAALDVRKRLKDLGLESWVKTTGGKGLHVVIPIEPELEWPQIKQWCHGFVNLMERADPKLYLTKMTKSARAGKIYLDYLRNERGATAVAPYSPRARKGAGVAVPLAWSELDEPERPVFRVATFPEWGGRLKKDVWADLPKTKQRISKEAQKAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X241</accession>
    <name>E8X241_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3273</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3273"/>
    <dbReference type="EnsemblBacteria" id="ADW70284">
        <property type="protein sequence ID" value="ADW70284"/>
        <property type="gene ID" value="AciX9_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3273"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_1_2_0"/>
    <dbReference type="OMA" id="RMAPMHW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="33731" checksum="CA465A8F1DDE5483" modified="2011-04-05" version="1">MRKIAQLWKLVQESHAEPLKGEAGKPIALQQGQAGAMFLGHSSFLLGIGGKNVLVDPVFATRLVLLRRQRRAGVEIEDLPAIDVVLVTHAHMDHLNRPTLRKVARATKRLTGKGPIAIVPDGVADLLKGLGFSEVRTLKWWESNQVAGLKVTLTPCQHWGARMFKDTHRLFGGFVVEGGGQTIYHSGDTAYFAGFAEIGRRLGPIDVALLPIGAYFPDSYRAVHTSPEEGLQGFVDVGARWMVPMHFGTFKLGREPFDEPPIRLMAEARRRGIEDRVRVLGEGETLVVGGDEDEVKAGDVLYAGASNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X254</accession>
    <name>E8X254_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3286</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581609.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70297">
        <property type="protein sequence ID" value="ADW70297"/>
        <property type="gene ID" value="AciX9_3286"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3286"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="LHMESAR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="28518" checksum="CB8788787EFF1A34" modified="2011-04-05" version="1">MAAAVVVVAPIAIHAQVPLGQAAASYDVVSVKPNKSGPNGMSWGSTADGYRATNVSLGMLIQSAWNLKTEDLIYGLPKWDHDARFDVEGKMDADAVATLKQLPPKEARVQRDLMMQNMLIERFHLQIHHDIKQLPVYNLNVAKGGLKVKEADPANAYPEVKMGSSRVAGAGSMMFGPGQFTGNAVTLAALADNLSGTLSRLVIDKTGLTGKYDFALKYAPDDAPTTNDPGPSLFTALEEQLGLHLESTKGPVDTIVIDHLEQPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D2</accession>
    <name>E8X2D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579388.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68064">
        <property type="protein sequence ID" value="ADW68064"/>
        <property type="gene ID" value="AciX9_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0997"/>
    <dbReference type="eggNOG" id="ENOG50332T5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2649372_0_0_0"/>
    <dbReference type="OMA" id="MRSDLIF"/>
    <dbReference type="OrthoDB" id="1981337at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="76" mass="8831" checksum="A0D5AF4787FA9065" modified="2011-04-05" version="1">MRSDLIFGALTHVTNRYQLCQLASKATRKLHKPNTRLQDTTNEVLDRFKDTIPMDDAPEPKVEKIHAEDRQERRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D8</accession>
    <name>E8X2D8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579393.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1004"/>
    <dbReference type="EnsemblBacteria" id="ADW68070">
        <property type="protein sequence ID" value="ADW68070"/>
        <property type="gene ID" value="AciX9_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1004"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_0"/>
    <dbReference type="OMA" id="MALKMYD"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="21229" checksum="6270A5A02759927D" modified="2011-04-05" version="1">MIVGYARTSTNSENTDAQRSALRQAGCKKIYEEVLSGRTMDRPELERCLNRLEKADTLIVWRLDRLARSLRDLLEIISRLEKSGIVFVSLKEKLDTSAASGWLIFHIFASLTQFERELISERTTMGLAEARARGRVGGRKRLMSAQQIRAIKTLWANHDHTKQSIATQFGVSISTVDRIVRPKSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E1</accession>
    <name>E8X2E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1008</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579396.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1008"/>
    <dbReference type="EnsemblBacteria" id="ADW68073">
        <property type="protein sequence ID" value="ADW68073"/>
        <property type="gene ID" value="AciX9_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1008"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077422_0_0_0"/>
    <dbReference type="OMA" id="AHIRPYG"/>
    <dbReference type="OrthoDB" id="1629654at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="35799" checksum="B777DCE1793BE4F6" modified="2011-04-05" version="1">MRLFVAVTDSEWFGLHASKSQVDEVNFWRPSPDATFKALQPGELLLFKLHAPDNFIAGGGFFTKFLQIPVNLAWDSFREANGVRSLHDMRERIGFYRRTLMLPSENPTIGCVMLAEPFFWPREAWIPSPPDFRLNTVQGKGYDSELGTGRALWEEVAQRIELFQPASLQPGTAALAAIESNGFGKPQITLPRLGQGLFRVLLTDAYERRCAISGERTLPVLEAAHIKPYAVVQRHELSNGLLMRSDLHRLFDEGYMTLDPKDRRVLVSSRIREEFDNGKDYYKLEGQLVREPTQVWARPTLENLEFHAYNIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W7</accession>
    <name>E8X2W7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1038</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579424.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1038"/>
    <dbReference type="EnsemblBacteria" id="ADW68101">
        <property type="protein sequence ID" value="ADW68101"/>
        <property type="gene ID" value="AciX9_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1038"/>
    <dbReference type="eggNOG" id="COG3024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178280_1_0_0"/>
    <dbReference type="OMA" id="KWASGDY"/>
    <dbReference type="OrthoDB" id="2071775at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00649">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005584">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03884">
        <property type="entry name" value="YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8289" checksum="D83033EBE0DADA95" modified="2011-04-05" version="1">MPNPKALFCPTCRKVVLATDPDFPFCSDRCRILDLGKWASGGYVISSPVHDPDLLDELEGLQHRGQSSTNEDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X342</accession>
    <name>E8X342_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580582.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69266">
        <property type="protein sequence ID" value="ADW69266"/>
        <property type="gene ID" value="AciX9_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2224"/>
    <dbReference type="HOGENOM" id="CLU_1649740_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="17721" checksum="43F83B2011C607EA" modified="2011-04-05" version="1">MAGLLVVGIPFLVVCVVVASFIMLSTLSNRRNVQFAAARGVTYEKHGKTPIAVPKVVYGQRDLNETSSFLYGPWHGVDCFACDFRIGWGRGSVEWLSMVAIHAELQAVSGLDLKRWVLTPLNGWTFLVPREPKGGTLKIKKVIELWDLLAAAIPNIDQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X361</accession>
    <name>E8X361_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580601.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2244"/>
    <dbReference type="EnsemblBacteria" id="ADW69285">
        <property type="protein sequence ID" value="ADW69285"/>
        <property type="gene ID" value="AciX9_2244"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2244"/>
    <dbReference type="eggNOG" id="COG2140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1515863_0_0_0"/>
    <dbReference type="OMA" id="KEFEWHE"/>
    <dbReference type="OrthoDB" id="1881621at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234313" evidence="1">
        <location>
            <begin position="36"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="18929" checksum="47A08AA17259EEA4" modified="2011-04-05" version="1">MAILDSRRSFLRIAPLAAAASLTLAENLLSVPAHAQASTGAAVIPFQLFTAQSLESSEKALQAAPGNKTLIDVKQLPVTVVMTSETAKAGKEFEWHEGRDHIVQILDGATLYEVGGTPKNGRNTKPEEWLAPESEGHTTYNLKKGDMLFLPRNTPHKRSTSGTVSLVLISTVGSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X388</accession>
    <name>E8X388_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2274</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580628.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2274"/>
    <dbReference type="EnsemblBacteria" id="ADW69312">
        <property type="protein sequence ID" value="ADW69312"/>
        <property type="gene ID" value="AciX9_2274"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2274"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_0"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230621" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="30"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="74"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="483" mass="49928" checksum="8D830A2B40E3988B" modified="2011-04-05" version="1">MRFSALKVHLAFLAILTLGLTSAPSKAFAQAAAPAMTASAPAADPTSRIAALEKQVADNTAATAAAQTAGDNGWMLVSSALVLMMSIPGLALFYGGLVRKKNILGTMMQTFAMCAVITVLWALVTYSLAFSSGSAFIGGFSNVLLHGVGLQLAKDYAPTIPLQTFMVYQLMFAIITPALITGAFAERVKFSAMLVFMVLWAFIVYSPMAHMVWGIGGLLNVVGGKFPCLDFAGGTVVHVTSGVSALVTALYLGKRLGYPKVPMPPHSVVLSFIGAGLLWVGWFGFNAGSALGAGTLATSAFVATHFGAAAAALGWSAAEWIKNGKPSALGAISGAVAGLVGITPAAGFVTPMSALWIGLIVGIFCFFMVVTVKALFGYDDSLDAFGVHGAGGTMGALLTGIFANSVINPVFGAGKATGALEGNPHQLLNQLTGVAIAWTLSIVGTLIILVVVDKTIGLRVSEEDEREGLDLSQHGEEGYDWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D1</accession>
    <name>E8X3D1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3426"/>
    <dbReference type="EnsemblBacteria" id="ADW70432">
        <property type="protein sequence ID" value="ADW70432"/>
        <property type="gene ID" value="AciX9_3426"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3426"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NTNINRW"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1253" mass="134135" checksum="F0AEB90EDEC9373A" modified="2011-04-05" version="1">MTLDSFNPQNPRAPRRTRRIHGLFLAVAAVALMITAVASAQLAGKGALRGSVTDSTGAAVPGATIVVTNIATNTKQTLVSTSAGDYEVSLDPGKYTVTVTLAGFKSFVQQNIQVDALQTFGVNAQLQTGDVSETITVTDAPPTLETSNATLGVTLEQEQYSNLPIIQDGGGQRRATDLASLLPGVSANVSNGNLTTNAGIVNGGGSRGATSSIYINGVPITSVAGEGDPRFVWTSLAVDSIDQLQVQTIGYSAIYEGQGVQNYVVKSGSNKLHGVVYDYFRNTALDTWGFLAKYSPNLPATKPVEHQNEYGAFFGFPIIKDKLFVFGGYEGYRYSRLVPQQQETIPTLLQRTGDFTESAANPIYDPNSTQFFAACPTNTKVSCYQRTPFMGVKNGIPTANVIPTGRLSPVALNLEKYLPIPTTGDLANNYVVNYHTGLNNWSTANRIDYHVSERQSISGVIAFGRQSTTAPSAVVVSSGTTTNGLPPPYISTQQFAPKTKVLLFEHDYTFTPKVINQFKYGYGRYDGPGYNQDEGNGFGAAANGITGLPAGQASDSFPTVTFSGNTNINRWAGYSSNRPVASGYVAVDNVQWNLGKHSLTIGGEVAWLQYNYLVNATGVNPLQLTFSNSLTAGYTPSSTTQVTTSGIGYASFMLGAANSASFTQSSVPETGARFRPISPYIQDNWKVNSKLTLDIGLRYDYYPTYKEVKDRFSFLDPNAINPLTGTKGAIAFGGTGVGTCNCHQPVNDYLKNFGPRIGMAFSPDPKTVFRGSYAIIYTHGNDNGGSASSRQGSGLEGFSVTPTTTVVDPTAAQTGTTYYKLDNPYPSYTLPPTLNAGLGTYYTTNSTQSPQTPTYADPYYGGRAPQFINWSFGLQREITSNMALTISYVGSQGHFLQPDSLIARGTASNALDPQYLALNTKLNDKTSTAAGLADLASVGKSLPYATFGGIGNPAVSQALKPFPQYSSVSDSFGFVGNSRYEALQVYLTQRLAHGLTFMTNYTWSRSIDNNGTFRSGYDISAQFASDGKFHAARSLDKSLSLGDQRHKFVITGAYDLPFGKGDLGGGHFITRALFGGYKLSTIFQAFSGAPLSIIQNSCPTNPAIANTNACTPFLNPAYSGNGRKAGTLPFTAANLSKNIYLDSNAFLSAAASPTYMFNTTARTAPYSGLFQPPNYKLDMSIRRSFPIPTGGLHDGTRLTFEADMFNVTNHTHFVYSALNAPLTSFGTSSYGTLTVDTNSPTNRAVQLAARIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S1</accession>
    <name>E8X3S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580665.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2312"/>
    <dbReference type="EnsemblBacteria" id="ADW69349">
        <property type="protein sequence ID" value="ADW69349"/>
        <property type="gene ID" value="AciX9_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2312"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_1_0"/>
    <dbReference type="OMA" id="MPLNHQL"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014085">
        <property type="entry name" value="Allophanate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="600" mass="63231" checksum="87A45CAA542329E3" modified="2011-04-05" version="1">MNIEALHREYAAGTTTPAQIVEAIFARIASEGVHPVWISLIPKEQVLQRAAALQNQDPTKLPLYGIPFAVKDNIDVANHPTTAGCPAYAFTPTESATVVAKLEAAGAILIGKTNMDQFATGLVGTRSPYGAPSSVFSKDHISGGSSSGSAVAVASGLVAFSLGTDTAGSGRVPAMFNNLIGLKPSRGVLSTHGVVPACRTLDCVSIFTQTAADAAAVLDVASGPDPKDPYSRTPTPGAGASPWAAASTFKFGVPAPSALQFFGDTHNPALYQAAITALKSLGGEPVEFDLAPLLAAAQLLYKGPWVAERYAVISDFIQAHAAEMDPTVAKIINGAASYTAVDYFDSAYKLQHHLRQTEQAWKAFDLILLPTAPRTFTHAEIAESPIERNSQLGFYTNFVNLLDLSAVAVPAGMRPDGLPFGVTLIGKTLAEAALLPLADSLQRKLNQTLGGSKDLLAGTTPLKPATTPTGTLLMAVVGAHLTGQPLNWQLTDRGGKLVRTCRTHPDYKFYALKNTTPPKPGLVRVPGFEGKGIEVEIWALPSDTVGSFVDGVPQPLSIGKLRLEDGTLVMGFLVEPEATQDAFEITNLGGWRNYLATLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X415</accession>
    <name>E8X415_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6298 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3518</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581834.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3518"/>
    <dbReference type="EnsemblBacteria" id="ADW70523">
        <property type="protein sequence ID" value="ADW70523"/>
        <property type="gene ID" value="AciX9_3518"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3518"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292520_0_0_0"/>
    <dbReference type="OMA" id="PNAFVQC"/>
    <dbReference type="OrthoDB" id="134320at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046265">
        <property type="entry name" value="DUF6298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19815">
        <property type="entry name" value="DUF6298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234148" description="DUF6298 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6298" evidence="3">
        <location>
            <begin position="487"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110000" checksum="54E9B56B8431BB7D" modified="2011-04-05" version="1">MRVSPTPLLLLAFTAPASISFAQTAAVPHNPTGIDFSFAGYEAGPALPSIPAVLTVRPTGSDDTALLQSAIDRIATLPIQPNGFRSALLLQPGRYRIAGQLTLRASGIVLRGSGPTNTTLIAEGLSRRSLIEAGALTDPTLATPIEVTEDAPAGSLTLTLTSTDSLTTGDHIVVRRPSTAPWISAISMSGLPGTFANQRLDWQPGSHDLVWDRTILSIDPTTHTITLDAPITTALEKQYGAGTVAKLTGQPPITHIGIEDLTLESTFDPANPKDEDHAWIAILFDHLEDAFVRNVTTRHFAASAVHVNLRARRITITDTHAESPIAEFAGYRRQSFLIDGQQVLVRHSTSEAGMNDFASGLLAGGPNVFLDDTATASLGASGAFEGWSSGILYERVHIPNARLQLLLDFSRAQGAGWTAANSILWNSTAQSVDAIGPPAAANYVINSPQSLYETQLQARIGTTLLPETSVSSSFPPSPLWFASPKAETPANPPQTHPVQIINGRFVLEGKTLWGPSQGEAWWRGDTSPYTAGKSTGSSVSRFMPGVTAPGLTEDLPEMASRLKARGIVSIQINPGLWYDHRRDAHTVERRDDGNVWAPFFEAPWARSGQGTAWDGLSKFDLSRYNPWYFERQKQFAQQAAQQGFLIFYDLYNTHDVLEIGPHWIDYAWRPANNINNTGLPEPPPLKPHNRNDVGNQFFSTTNPELKALHRAYMLHTFDQLGDQPNVIFGIAYQYAGPLEFEQFFQDTAREWESTHPGRHIRFALTTSKQTTDAILQDPIRSKQIAVVDMRYWEYRPDGTLFAPKAGENHAFRELISLAFPGYTDTPPVTTPEQVYRATREYRDRYPNIALMPMEDGAGPIPILMGGGASQSALVGGRTPAPKPSAEQQASAMYPLRPATAPPEHANADHNLEAFIQTNLATSLMNLSPRDGWTAAPDHTWTLAGSPKDPILLYSLSGPDITLTHPLPHTHYAAQWFDPETGQTQPAEAKQSTYAKPNASPWLLLLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X424</accession>
    <name>E8X424_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3527</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3527"/>
    <dbReference type="EnsemblBacteria" id="ADW70532">
        <property type="protein sequence ID" value="ADW70532"/>
        <property type="gene ID" value="AciX9_3527"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3527"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161295_0_0_0"/>
    <dbReference type="OMA" id="HGRNLMP"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="12749" checksum="18C8A57E264A3185" modified="2011-04-05" version="1">MIEKMKFTVPVLLATALLTGCHSTPPPTPLAQLNPQQMRGHDAFQTKCAVCHYDRRTGDLHGPSLLGVFKKPALPSGAAATDERVSATIIHGRNLMPAQGNHLETGDLEDLLAYLHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X435</accession>
    <name>E8X435_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M56, BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0004</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578424.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0004"/>
    <dbReference type="EnsemblBacteria" id="ADW67095">
        <property type="protein sequence ID" value="ADW67095"/>
        <property type="gene ID" value="AciX9_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0004"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="PMRQISG"/>
    <dbReference type="OrthoDB" id="1335347at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="28624" checksum="7ECB57D9B8AC7F17" modified="2011-04-05" version="1">MVKLEAWRWVAVTCFGLTAYGFSQEKATPLTFEVATVRLTKPGELDGWIKALPGGAEYTAHNIPVKLMISLMYKVPMRQISGGPDWMETDKYDVEAKADKSYSLDDLHTMYRGLLAERFHLKVRKEIHEGPVYALTVDKGGVKMKPDLSEQSYAIPITYSGEGAVGNRVPMSYLSWWLGQQLQSESRPVVDETGLKENFDFTLSFTPPRLEGTDGGAAEKPSLFTAVKEQLGLKLEAQKGPVEYYVIEHIERPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X472</accession>
    <name>E8X472_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0041</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0041"/>
    <dbReference type="EnsemblBacteria" id="ADW67132">
        <property type="protein sequence ID" value="ADW67132"/>
        <property type="gene ID" value="AciX9_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0041"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118579_0_0_0"/>
    <dbReference type="OMA" id="CPCTRAS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="21993" checksum="20E6E95CE18006D6" modified="2011-04-05" version="1">MPALGLVWLLAMVPGVRYLLAYEHTAGSQGTAPRGWPKGMPQVGDAALPTLVVALHPRCSCSQATLAELEEAAQGFGHPYNAVLLIYRPKGSDYEWQKVDLYRDAQKALHARVMLDDDGQYSAAFGAETSGEVLYYSAAKGAAGRRLLFSGGVTGSRGMVGGNDGIEALKSAFKLDREPEHAKTPVFGCGLFAALEPQAAEKRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X488</accession>
    <name>E8X488_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Platelet-activating factor acetylhydrolase plasma/intracellular isoform II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0057</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578477.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0057"/>
    <dbReference type="EnsemblBacteria" id="ADW67148">
        <property type="protein sequence ID" value="ADW67148"/>
        <property type="gene ID" value="AciX9_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0057"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026278_2_1_0"/>
    <dbReference type="OMA" id="LMISIWY"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="48996" checksum="F6C223A3EA94D88C" modified="2011-04-05" version="1">MRIIDWVLPALGLLGAVLLVLGAPRAVLWALMAIFAAALAAHFILIGTYWQRVPVYLAFLILCYASFTPEQTKARGISVFAIALLSCLSAGLTFELPLFTLPPPTGQNPPSTSTFYLTDFTRDRSLVVQVWYPANFSGGFDSRRAKYARSKELRPFYRYQSRIQTNSYDNAEMAKNEGPFPVILFNGMWGGRRTQDTFLMEDLASHGYVVVAVDHPGNAARVEMADGQVVYSTMKTAIDTIPGRTPQQIRATWEKELAVWVDDNRFVLDELERMNAGGWATGRLDVRNVGALGHSFGGAASFALLGADARVRCAINMDGWSFGGLDHRTTQPILLMYEDSYKGNQPGAGAEWELDTADKALVDQSLQSFGGTRVYITGTRHADFTDATLFSPIKRVTATGSIAGDRIRTIIRKTVLCFFDQELKGHGTLPAFPESELQNWKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B6</accession>
    <name>E8X4B6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579566.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1180"/>
    <dbReference type="EnsemblBacteria" id="ADW68243">
        <property type="protein sequence ID" value="ADW68243"/>
        <property type="gene ID" value="AciX9_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1180"/>
    <dbReference type="eggNOG" id="COG2514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059557_0_0_0"/>
    <dbReference type="OMA" id="GGYHHHM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="32506" checksum="DBA810F4AC21CA20" modified="2011-04-05" version="1">MTPTPSPRTDAGIHPTHRLPPSTHVGKVRLAVSNLERSVAFYRDVIGLTLLPSLESASKIARLGVPGSPAALLELEHIPGVQPIGRRTRLGLYHTAFLLPTRAALGSFVQHLIASNTPYGAGDHLYSEAIYLADPDGLSVEVYADRAHSAWIYEGSELVSATNSVDFRSLLAATDAPWKGAPSGTTIGHVHLYIADLDQASSFYHAALGMDIMTWRYPGALFVSAGGYHHHVGLNVWAAGSPVASAYDARLLFWELILPSEQELELAAKRLTEAGFPSETSEEETPSHIDSCGIRLRLKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H8</accession>
    <name>E8X4H8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">AciX9_2351</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580704.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2351"/>
    <dbReference type="EnsemblBacteria" id="ADW69388">
        <property type="protein sequence ID" value="ADW69388"/>
        <property type="gene ID" value="AciX9_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2351"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_0"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="45451" checksum="4BC3916131EBBBFA" modified="2011-04-05" version="1">MSTEIIHPARSLQGSLVLPGDKSISHRYAMLAGLAEGTTKLSNFSTGADPHSSLGCMAALGAEVKDLGTHIEVTGVGGSFRQPTGDLDCGNSGSTMRMLSGLIASHPHTFTLIGDHSLTVRPMERIRKPLEQMGARIALVDGHAPITINGGPLKAIDFDTPIPSAQVKTAVLFAGLQAEGTTSLSEAITTRDHTEHALRAFGAKLTRETGERPRLVIAGGQKLKAIEATVPGDLSSAAFFLCAALLFPDSNLILDSLGMNPTRSALLDVVAALGAKIKVLNVEEQHGELIGTIQVNAAPALSRGPMEISGALTAQLIDELPVLAAIAPYTRHGMIIRDAKELRVKESDRIDLVARNLRAMGATLTEHEDGMEIPGGQTLHGAQIDSGSDHRIAMAFSIAGLRATSATEINGAEAAAISFPEFFTHLRNLCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I4</accession>
    <name>E8X4I4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Substrate-binding region of ABC-type glycine betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2357</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2357"/>
    <dbReference type="EnsemblBacteria" id="ADW69394">
        <property type="protein sequence ID" value="ADW69394"/>
        <property type="gene ID" value="AciX9_2357"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2357"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_1_0_0"/>
    <dbReference type="OMA" id="APMNNTY"/>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="32373" checksum="13ECFC268AC0581B" modified="2011-04-05" version="1">MPLKLFLPALLLLTACAPPRSSRITIGAKNFTEQVVLGELLAQQIEAETHQKVDRRFYLAGSYLCHQALVSGRIDAYPEYTGTALTAILKQPLDRDPARVDETITRLYEDRFHIKVEPSLGFNDTFAMVVRGADAEKHHWKTISDVLPVASTLRLGVGYEFQARPDGLDGLQSTYGLHFGARPRVMDLGLLYRSLASNQVDIVAGNSTDGPIKALGFRILEDDRHYFPPYEAVPLVREDSLAAHPEIQTAMNKLAGKITAEQMQQMNDQVDGKHQDVAEVVRHFRQTHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L6</accession>
    <name>E8X4L6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2389</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2389"/>
    <dbReference type="EnsemblBacteria" id="ADW69426">
        <property type="protein sequence ID" value="ADW69426"/>
        <property type="gene ID" value="AciX9_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2389"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037625_0_0_0"/>
    <dbReference type="OMA" id="DELYFIA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="66"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="58186" checksum="CF63E1AE1D4AA091" modified="2011-04-05" version="1">MSDTTVVRPTDPELRSAVRLAAVFALITFLFHLLVNLSQPHLGWGYFRDEFYYLLCGRHLDWGYVDHGPLVAVQARLAETIFGHSLAGIRMFTALGGAARVFLTGLLAWSLGGRRAAQTLAMFAVSLAPIYLVLDGFLSMNSWEAAFWMTCALAVILMHQGRTPKLWLLFGLAAGLGLLNKPSMTFFLIALLLALLITPQRRLLFTPYLLGGIALIVIITAPNLLWQLHHHWATLEFLRESTHHQDHPSFLNLLKSQVLGLGPISAFVWLPGLYWLLRRPAQRWLGLTYIFFFAAMAALHAKDYYPTPIYPILFAAGGLFWQSRIPAQRQSRLVAFPILQTAIFALGILILPLGNPFMTPAQWISYIRTTHLRAAAGISGDAFFPQYLADRFGWDEQLALVHQALAQLSPADLSQVRILCANYGEAAGLEYLDGPNLPPVISGHNNYWFWGPQAATGEVMIVINGATPQQMLESYKDVQVIGKITHSYAMPFERRATVYLARHRRQNLTADWPDLKHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N0</accession>
    <name>E8X4N0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_2403</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580756.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2403"/>
    <dbReference type="EnsemblBacteria" id="ADW69440">
        <property type="protein sequence ID" value="ADW69440"/>
        <property type="gene ID" value="AciX9_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2403"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_0"/>
    <dbReference type="OMA" id="CREGTDW"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW69440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="442" mass="47356" checksum="B901FF17620B24C4" modified="2011-04-05" version="1">MPRNVSHPDEAIVLKRRFGQGAANIDKYLELDGYKAVQMAIAQGPEMPTWIINVMKASGLRGRGGAGFPTGLKWSFVPKVSEKPKYVLVNGDESEPGTCKDHVIFLEDPHAVIEGTMIAGLAIGSKLGFIYLRGEYRYLLKIVEKAVAEAYAKGFLGKNIFGSGIDFDIITQTGAGAYEVGEESALMESLEGKRGVPRIKPPFPAVVGLYGGPTVINNAETIASAPHILLMGGEAYAKLGSERNGGTRLFGISGHVERPGVYELPMGYNLKKAIYEVAGGVKGGKKLKAVVPGGSSCPVLTADELDVGLDFDQMGKAGTMLGSGGIVVLDETVSIVEFALRVISFYQHESCGWCIPCREGTDWIKKTLARVYAGGGSKKDVDNVQYLAENMMGRTFCPLGDAAAMPTLGFVKKFRKEFEDYIDGNRAGTPVMSEQELVGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P0</accession>
    <name>E8X4P0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit c</fullName>
            <shortName evidence="11">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpE</name>
        <name evidence="14" type="ordered locus">AciX9_2413</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2413"/>
    <dbReference type="EnsemblBacteria" id="ADW69450">
        <property type="protein sequence ID" value="ADW69450"/>
        <property type="gene ID" value="AciX9_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2413"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_0_2_0"/>
    <dbReference type="OMA" id="ARPGIFI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230225" description="ATP synthase subunit c" evidence="12">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="13">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW69450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="10953" checksum="A9E707751B1044CC" modified="2011-04-05" version="1">MNRMLQAGKYFFMTLAAMMLAVPAFAQGAADESHWWVSIGAGIGMALAAGLCGLGQGRATASATEALARNPGARPGIFIFLILGLAFIESLALFTFVIIFLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V3</accession>
    <name>E8X4V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3589</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581903.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3589"/>
    <dbReference type="EnsemblBacteria" id="ADW70592">
        <property type="protein sequence ID" value="ADW70592"/>
        <property type="gene ID" value="AciX9_3589"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3589"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_4_0"/>
    <dbReference type="OMA" id="DQACLVG"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="20322" checksum="CE397F20854ECE67" modified="2011-04-05" version="1">MSSDSREKILTAARLSAQAHGYNGLNFRDLAEDVGIRAASIYHHFPSKAELATAVAKRYWQDFAAVLDGLLAEAGDASVALHRYPETFRWALENENRMCLSGFMAAEYDDLPKEVKTEVQSFADVNVAWLSKVLAAAKVVGPKKSEARARAIFAAVGGAQLMARSRSDVALYDALIESYRAAGLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X506</accession>
    <name>E8X506_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0120</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578526.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0120"/>
    <dbReference type="EnsemblBacteria" id="ADW67198">
        <property type="protein sequence ID" value="ADW67198"/>
        <property type="gene ID" value="AciX9_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0120"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_0"/>
    <dbReference type="OMA" id="AFMIRAC"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="203"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="33741" checksum="2AF3A895491CCB33" modified="2011-04-05" version="1">MDPFLDLIRLLRPRAMLTAGIRATGRWGVSFRQRNDVLFCWLEKGECQLVRAHAEPLQLRPGDFVLIRTTTPFTLTSDPSVEPEDSETIVATTNDPELRLDKGSGLTSILRGGRFVFDTTNEELLTGLLPSLVHVSGNDISSWRLQSLLKLNETESAQRGLGSDFIVTRLIEVILVEILRREAKKVDQRQTGLLAGLNDPVTSRALALMHADVAHDWTVAILASRCNVSRSTFAAHFRKVVGIGPIDYLLRWRMTLAKDELRRGTRSIGEIALAVGFQSSSAFSTAFTKAMGCSPRKFLRQPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X508</accession>
    <name>E8X508_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67200">
        <property type="protein sequence ID" value="ADW67200"/>
        <property type="gene ID" value="AciX9_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0123"/>
    <dbReference type="HOGENOM" id="CLU_3234226_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="43" mass="4847" checksum="3E3289E3B1B11D24" modified="2011-04-05" version="1">MHALTEISRKSLSTNNFGRMFARFLAKFVETVDARDVGVMTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X549</accession>
    <name>E8X549_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1251</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579636.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1251"/>
    <dbReference type="EnsemblBacteria" id="ADW68313">
        <property type="protein sequence ID" value="ADW68313"/>
        <property type="gene ID" value="AciX9_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1251"/>
    <dbReference type="HOGENOM" id="CLU_2569057_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="9689" checksum="C4BB5E7984FF726C" modified="2011-04-05" version="1">MAKQTEKINILEDAGYRYNFDRMMYINRNVRKAFSVEFIDDKAASEITEKIQHQKANEDWEFYTTSHLSDGIVRELKRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X550</accession>
    <name>E8X550_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579637.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1252"/>
    <dbReference type="EnsemblBacteria" id="ADW68314">
        <property type="protein sequence ID" value="ADW68314"/>
        <property type="gene ID" value="AciX9_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1252"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_7_0"/>
    <dbReference type="OMA" id="NGYLVEY"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19376" checksum="02274AF644B042D5" modified="2011-04-05" version="1">MPLTVPVGPKDHTQGPTDAPITLVEYGDFQCPSCGSAYTVVKKLQRHFGKRLRFVFRHFPLTDMHPMAEPAAEAAEYAATESEEKFWAMHDLLFENQQTLSTDLFADLAEELELDATKLEKAVHTHKFKSRIAADLESGDASGLTGTPTFYINGHQHKTAYDYTTLSEAIETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H5</accession>
    <name>E8X5H5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2489</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580838.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69522">
        <property type="protein sequence ID" value="ADW69522"/>
        <property type="gene ID" value="AciX9_2489"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2489"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369105_0_0_0"/>
    <dbReference type="OMA" id="NETLTYA"/>
    <dbReference type="OrthoDB" id="256423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="367"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="454"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="628"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="754" mass="74856" checksum="D20EF9A765014702" modified="2011-04-05" version="1">MPVVVDRTRPRTPAAQPAWSSPSPLSVLRRRLSLDRSRSERPFLIAVLFSLALLGSLFALSTLTGCGSAPVPTHLAALTVGSTVVQSGQSLNLILPAGVQTPNASDVTVTMSPVSGSGTTYTLAVNSIGPGSNGTSVLRVTLPTLSITVPTPYSFTARSSNYYSGFDTAPVQITIQPGPAILSVAPVTAQAGQTVDLTVTGISTAWTSGTTTLLAGPGISVNGSTPGIPGQPQVQSSTQLVAHLTLALTATVGPHDIVVATGSQTLTLTGALAVTAPPLAPIAAVGGPYIGTTGQPVAFSAAASTDPAGLALTYAWTFGDGSTGTGATPTHTYATAGSYMVIVVVTNSAGVSSSATTTAIITDPAKPPVANAGGPYTGTAGTAVAFNGSASTDPKNETLTYAWTFGDTTSATGPTPTHAYTAAGTYTATLTVTNTDKLSTSATATVTIAAAPQAPVANAGGPYTGTAGTAVSFNGTASTDPKNETLTYAWTFGDTTSATGPNPTHTYAAAGTYTATLTVTNTDKLSASATATVTIAAAPQAPVANSGGPYTGTAGTAVSFNGTASTDPKNETLTYAWTFGDNTSATGPTPTHSYVASGTYTATLTVTNTDKLSASATATVTIAAAPQAPVANSGGPYTGTAGTALAFNGSASTDPKNETLTYTWTFGDTTSATGPTPTHTYAAAGTYTATLTVTNTDKLSASATATVTIAAAPQAPVANAGGPYTGTAGTAVAFNGSTSTRPQKRNPHLRMDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H6</accession>
    <name>E8X5H6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2491</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580839.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2491"/>
    <dbReference type="EnsemblBacteria" id="ADW69523">
        <property type="protein sequence ID" value="ADW69523"/>
        <property type="gene ID" value="AciX9_2491"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2491"/>
    <dbReference type="HOGENOM" id="CLU_952374_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234405" evidence="2">
        <location>
            <begin position="29"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="32079" checksum="F24718E92A8BD63A" modified="2011-04-05" version="1">MKKLPVIRPLQSLILLSLIAASGILAHAQTPAQTPTQTPVQPPATKPPAPAAAKPLVPDGPLASDNKHYTSKDLSVRPYSPAIPAPLYPSSQRKQSQFTVQYVFNYATSNYTPPVPLALVSRAAARHDSPEAALTAYYSAMRSGDYEAWLQCWDEPSRKALEATTKQQKNGAEYWRALWRTAFANKRYFLIDRLETVNYIILDTRIEDPAKPAATQTDSEVLVINSGKWTLTNAFSNDGLIMNYDGTANKVVKEYEIAPTKELTGPAALTGEAQKEFFARHTTVASVTKTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I5</accession>
    <name>E8X5I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3609"/>
    <dbReference type="EnsemblBacteria" id="ADW70612">
        <property type="protein sequence ID" value="ADW70612"/>
        <property type="gene ID" value="AciX9_3609"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3609"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813612_0_0_0"/>
    <dbReference type="OMA" id="RRGHFKG"/>
    <dbReference type="OrthoDB" id="1840926at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230731" evidence="2">
        <location>
            <begin position="30"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="34235" checksum="3FB0CAABE65218CE" modified="2011-04-05" version="1">MIDARNGMRQGLTVGALALTLAFAGCKSAADKANDAAIAQAKQQATATGSPQQVVWTDKDGNTTTVVVQPPAQGQATQQVTTTVTKRQVSGGNTTQSTSTSTSMQPVVGPVVQQPVSGPVGPPGQYGTQQPVNGGPGYDNGASAPGAAYNGPAQSGPAPVGSGPVVSPLNMNVPRGTTLAIRVNQTINVKTSRAGDRFTGEIARPVVEEGREVIPTGTPVEGVIDASHRRGHFKGRSILELRLVAMRLNGTRYELDTRDNVRTKKGKGKRSAAFIGGGAGLGMLVGGVATGGVGLLVGGLAGGGAGTLVGGLTGNRDIVIPAESIVDFKLADDLAVSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L5</accession>
    <name>E8X5L5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3639</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581953.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3639"/>
    <dbReference type="EnsemblBacteria" id="ADW70642">
        <property type="protein sequence ID" value="ADW70642"/>
        <property type="gene ID" value="AciX9_3639"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3639"/>
    <dbReference type="eggNOG" id="ENOG502Z9U5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890719_0_0_0"/>
    <dbReference type="OMA" id="DTYIVHG"/>
    <dbReference type="OrthoDB" id="1006633at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="34061" checksum="46969ADDCE3B5890" modified="2011-04-05" version="1">MTATENTALTSQITAAASAAGLQVLSSEPSTGSAGLPTTRFTLALASDPTKTQTLELSQSFDPQTFAELLGKDLAAYFVESARRLHNPQPDLYLTLTGFPLRFSLFAWPFHESVAGADTSLVHGQANLVDGHDSPLHARLSAAMTVTFRDVVRAPEQPFAESFIYNAIRKTFDQGQLELVKSGNRQPVPVTTRYYSPRSQKFTFTDTKEDQRTAYLAAKTYWLSGALGNGAPVWLLDPRDAQYLNASTAELRVSVDTLVKEGLITLSSDKEFATPTPALMAKQAEYEVDLAEALAFIKPTFNEDMRGGHTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V1</accession>
    <name>E8X5V1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4040</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70835">
        <property type="protein sequence ID" value="ADW70835"/>
        <property type="gene ID" value="AciX9_4040"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4040"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="GAMSENF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="279"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="40129" checksum="EB0F5A2D2A864E76" modified="2011-04-05" version="1">MAKSLSFTGFVFKNLLRRRMRTLLTLAGIGTAVGAFVGLVGFSSAFEQQWLRIYSSSGTDIAVIQGTFLNTSMDESTTAKLLKLPDVAQASPTIFNLMDLTPDVNALVYGWKADAFQFSSLQILSGRRFRDGQAEVMLGDMLAQNLKKAPGDNLDIQGKPFAVTAIYHGASTLEASAVVMPLDQLQELSSLQGKVSTIDVRLRPVPRGEASEQYLKHAETEIEAALPGMRAVPAAQRASDNQFVKLAHASAWGTSSLALLIGVLGIANTMAMSVFERTREIGILRALGWNRWQVLAHIEIEAVALGLGGGLVGIAVGWCGLRVLAALPQTASLVSASLHLPLLAEALGIAVFAGLIAGALPAWRAGQLSPVDALRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y2</accession>
    <name>E8X5Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4083</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70866">
        <property type="protein sequence ID" value="ADW70866"/>
        <property type="gene ID" value="AciX9_4083"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4083"/>
    <dbReference type="HOGENOM" id="CLU_2232750_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="105" mass="11119" checksum="4347F8759DDBBC12" modified="2011-04-05" version="1">MQAPDPHQLLRQLSATWQKVRIPAGKTVELMHFVSQEVLRSAGIAAAQRLIQLPPEALAGLTTTDATAIQNFSVPQNLTSALAALLSSPARSPAAQSPETASPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X664</accession>
    <name>E8X664_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4168</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572860.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70948">
        <property type="protein sequence ID" value="ADW70948"/>
        <property type="gene ID" value="AciX9_4168"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4168"/>
    <dbReference type="HOGENOM" id="CLU_2316357_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="11270" checksum="445092C404BC67DA" modified="2011-04-05" version="1">MEGTIVTNIQLLLSIGIPSALIVLSMIVGSRRDVVLNQRAKTVDEHTDVMPESIEARFDSVDRRFDEVFEALHNRKLAILRNMTDLHERVAIVESKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X683</accession>
    <name>E8X683_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4188</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70967">
        <property type="protein sequence ID" value="ADW70967"/>
        <property type="gene ID" value="AciX9_4188"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4188"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="WDFLNDA"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234231" evidence="2">
        <location>
            <begin position="48"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1191" mass="125841" checksum="0E7760BE84E47B49" modified="2011-04-05" version="1">MQGTKTQPRSQSRTKPSALLSRMLLSTAFTTGLAASALSLTVPSAYAQFRTSVQGSVTDNTGAAVPNATLTLQNLATNATVTHTSDASGVFNFNALPADHFKLTVTVPGFKTKVLSDLQFIPEQPNNLNVPLELGGVSETVTVDASENPILDTSTANIGATISANDIQHLPSFNRDVFTLTQLAPGAVSDGSQSAGGGVNSLPGNQGPGGSGSGGAAPTENRPQANANGSRNDANGISIDGISTVSAVWGGASVITPTEDSIDNVRIVTNDYDAENSRFSGAQTLVTSKAGTNHLHGSAFIAIHRPGLNAFQPSTGVGTPLRDTARFNQYGGSIGGPIWRDKLFAFFAYESSPNNSTATSTGWYETTAFRAAAPSGSIASTFLNFPGSAVAGTIVTTGETCALVGRVEGVNCRTIAGQGLDIGSPVKTGLGKQDLTADGTANNPGVGGGLDGVADVAFYSTATPSSSYYRQFNGRMDGNVTQKDHLSFTIYWVPQGTTNYNGGARAYNLFNHAQVNDAFSVIYNHTFSSNLLNEVRANASGWRWNEITSNPQQPVGLPQDNITYFGTSSATINQFGSSLGSILNQWTYGYKDILTKVAGAHTIKMGGDYTNLHYLNNPIGRPSYNFYNVWDFLNDAPYAESGQFNAATGLPGSSRSDDRENLFGGFVQDDWKALPNLTVHAGIRYSYFGPLYAKQGNLNGVQLGAGTASFTGLRVRNFDGLWTPQKGNFGPQLGFNYSPDAFHGNLVVRGGYGLNYNQEEIAITANSGFNPGLANQANFSFASPSNPGTNGGDIIYGISSSPTSLNGFAANPFTKAAYNTNGLPAAGNANIIIIGDGHGSLPTTYTQHFSLDTQYQLGRIAVLSAGYQGSVSRHLISHQTPNSLAVVSGAALNPLVPNGGGDFWDNEGSANNNALLLEAKHNSRQLSLDGQFMWSKSMDTNGSGPYYEDPYYPANPAFSYGRSDFNVGKSVKIFGLWQPVFFKGHSALEKIGGGWSLSGIFQYHTGFPFSPSYGIGQSLYCQQCGYQNVRPQYLGGAGNDHSNHAFINGSNFANPNNTAIPLTAVVNGQTTVVAFNNKYFNVPNYANLIQSSNGVESANLALPGQPGTARNSFDGPNYRNVDASLTKSFGIPNTRILGEGARFEIRADVFNLFNILNLNPGSVNTNIAANFGQDTTALGGRTISFQGRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M1</accession>
    <name>E8X6M1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3893</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71171">
        <property type="protein sequence ID" value="ADW71171"/>
        <property type="gene ID" value="AciX9_3893"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3893"/>
    <dbReference type="HOGENOM" id="CLU_1303439_0_0_0"/>
    <dbReference type="OMA" id="MEIIMIT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="28384" checksum="985EE714E6A6315D" modified="2011-04-05" version="1">MQLRTTAIRNRTPSPPPARNWAKFALWAMIGVTTLSVTLYSEVPLLHQAKERAYLGAMPFLIVPHIACGIFALLSGPLQFSTRLRQRHLQFHRLLGRVYVSSVLVAAPLAMVLSNQHHDRRAIHFVVANCCQASTWLIATAAAFLTARNGHIQQHKEWMVRSYAVTLTFVGTRVLQPLPAWNRHSEAGFAMEIIMITFLAILVPDIAFHWRQLTTRRLRSGAAIPSMKDQMRERRGVEKSVSAASGDSANLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q6</accession>
    <name>E8X6Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71206">
        <property type="protein sequence ID" value="ADW71206"/>
        <property type="gene ID" value="AciX9_3930"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3930"/>
    <dbReference type="HOGENOM" id="CLU_136060_0_0_0"/>
    <dbReference type="OMA" id="DDAICDY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16974" checksum="9917602753C6D9EF" modified="2011-04-05" version="1">MDLSDPDCPTIIKCKLHLEVSMQEEQIREALNAHWHASAIGDADLEHDIYDDNAICDYPQSGERILGRKNLQALRSHHPGKPSGFNVRRMLGEGDLWLTEYTITYQGRPAYTVSIMEFRNGKVIHETQYFADPFEAPAWRSQWVQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U4</accession>
    <name>E8X6U4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3970</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582262.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71244">
        <property type="protein sequence ID" value="ADW71244"/>
        <property type="gene ID" value="AciX9_3970"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3970"/>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_0"/>
    <dbReference type="OMA" id="EGLETWA"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20465" checksum="7DB06F2C0C7370AF" modified="2011-04-05" version="1">MAYPSKTDRATILAAAVEQLEEQGLRGLSLRSLAGSLELAPNALYRYFADRAALESALAGEVSRLLHAAMQRAVRKGRPEQAIHSIARAYLAFARSRPNLYELLLLPCDNAKEEADSHEKLWKFVVEHVSAITGPGHVNDASVALWAFLHGIAGLEAAKLFGDEKPVTSFDFGLAAWLAAASTSHAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X3</accession>
    <name>E8X6X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3796</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71082">
        <property type="protein sequence ID" value="ADW71082"/>
        <property type="gene ID" value="AciX9_3796"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3796"/>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="ASHTWIR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230297" evidence="7">
        <location>
            <begin position="30"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="252"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1494" mass="150974" checksum="EFFB0607E8537C18" modified="2011-04-05" version="1">MRRLTSLKLMSSHAAVLLTAALLPAAAVSQVKPLITKKIDANSRASLTHSIPAPVSKATDLGRVSSNLPMKDMLLTLQPSDTQKASLEAFLGDVQNPSSLNFHKFLSPFDFGIAYGPAQADIDTVSAWLTSQGFQVEGIAASHTWIRFSGTAATVETAFGTQMHNYQADGVKRISNSTELTIPSALAPVVSSVLSLNNFEKRSFHTPVNSVTRNSAGKLMRAATTQAQPAVSNADGTVVPAFTSQSQPEQNLLAPGDFAKIYNTSSIVANGNNGTGVSIAIVGRSDISLSDVETFRTLFKLPYNDPTFINANADPGVVVGDDEEAILDVEWSGAVAPMAQIKYVIGGSTATTDGVDISAAYIVDNKIAPIMSLSFGECEQALAPAELLFYNNLWQQASAEGISVLVSAGDNGSSACLAQNTHFATSLGFGVSGLASTPYNTAVGGTEFNDPTPDTFWTPTINADQSSAKGYVPEYVWNETCNTAAPTTTSNCYFQQAASAPAFAGSGGASTCSTHGTSPSILTGLYACTSGYAKPSWQTGLGVPADSQRDVPDVSLAAAGGHDGFLLCYNGSCQYTTNSDGSFSLTQASVIGGTSASAPSMAGILALVEQKNGQYQGLANYKLYALANAQTSTCNSSTQTDPTQSSACVFHDITEGSNTMTCTGTTAGCTVAVPGTTTYKQLSGWAATPGYDLATGLGTINAANLVSAWGNISQTATTTSLTLSSTTITHGSPVIVASTVTPASGTGTPSGSLLLVATGTTSTPGPVLASALTAGALNASVSSLPGGTYALTAQYGGDAAFTASTSSAVNVTIAPESSAMTVATLVKSRFFVLGRQPIVSGTSVGLDANWFISIGMAGKSGAGIPTGSVNITQGTSVIGSFPLDKTGAIYITCGPYTSCDYPIGTYTFTATYSGDSSFSAITQTFPFAITKGTANYSVSADRQIVTTGTPVTATVYIGYDPAVLPTGTVSLYRDDTKAVLGTGTINASGNAVITFNAPVGSYGADASWTGDTNYTAGIASSYPDMTVTAPAGIVTTSALKVSAATSSLGKQTSFAVSITPASKDSSGAVPTGTVTLYSKEEGQISAAVPVTGSAVTLFVQWPIAGTETVYAVYSGDTKYSTSTSALSAVAVSQATPSLSLTTLAPYVAVGGRDSITAVLTSAVSSTSAQTPTGTIQFFDALNGAASTTLGTPQAINGGNGGVILSTLAPVLASGSHVITAVYSGDTNWTTATSTTSVTIVSTTANFIFTGPKGLTITAGQSGTLALSTSSILGFSTPAAITCGGTLPEGFSCGTSTITPGTAGTLAVTSTAPGTVIAAFINGHDVLPWKVPGAVTLAGLALFLMPRRRRFTSLVALLLAASFAVLNLSGCGGAGTPATSQLSITSTNTKVASGSPAVFNALVSGGSNPTGTITFSDAGTVIGTSPVTNGVALFSTSTLSVGTHAITASYAGDNNNAASKSSDTLNQTVTGTFSLTVNATAGAVIHTTTVPVTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C3</accession>
    <name>E8X7C3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4407</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71357">
        <property type="protein sequence ID" value="ADW71357"/>
        <property type="gene ID" value="AciX9_4407"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4407"/>
    <dbReference type="HOGENOM" id="CLU_1276166_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="216" mass="23992" checksum="70E94D69CED5D291" modified="2011-04-05" version="1">MRLFRQPILAWVKERSIYETRRGGERMKLQRSISKLFKLLPSGILIVEPNPGLLAARVLLLSAADSYVAASNEVPPATDLQKTDVKVAVLSLSLGKPTLSKLAQEVRLYYPGARILIFGNSELDLDDQLYDETIDRHCRPEQLLDVLFRLARESSHQSIAYRLRIGAEALSLKGFGWVSSHRRPLESDPSKEAVSASADSPTGVDFPADETSPHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D0</accession>
    <name>E8X7D0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4414</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573083.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71364">
        <property type="protein sequence ID" value="ADW71364"/>
        <property type="gene ID" value="AciX9_4414"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4414"/>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_0"/>
    <dbReference type="OMA" id="WVTEMGV"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="186"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="720" mass="79528" checksum="EF5274A741296EBD" modified="2011-04-05" version="1">MANNKIILSSHTADFNSKSVSALGGTPSQGEASLRGVPVPLGVSLSLDGANFSIFSSSATGMTLLLFDHVDDSASRRSIRLDATINRTGHYWHIFVPSVHAGQVYGFRADGPSDPRNGQRFDSSKVLIDPYGRALAVGKNYSRADACRPGDNTATSMKSVVADMAAFDWEGDIPLGHSFRTTIIYEMHIAGFTGHPNSGVSETNRGTYAGVVEKIPHLQTLGVTAVEILPVFQFDPQSAPPELTDYWGYNPVSFFAPHLGYSSSGDPLRCLDEFRDMVKQLHRAGIEVILDVVYNHTAEAGDGGPTFCFRGLGNSTYYILNQEQTGYFNVTGSGNTLKTNQAVVKRMILDSLTFWVSEMHVDGFRFDLASVLTRDEWGQPMSDPPILWDIDSEPALAGTKLIAEAWDEGGLYQVGSFGHDRWNEWNGQFRDDIRSFLKGDRDTAWKLRERISGSYDLYRSGDRPAGQSINFITCHDGFTLNDLVSYDYKHNEANKELNKDGTNGNLSWNCGVEGASNSIEVNRLRKQQIRNGLVLTLLSAGTPMLLMGDEIQRTQGGNNNAYCQDNIISWLDWNWDQEQSELLRFTRLLVRLRLDCDNGTLHDGGKVGGFVNAHKMEWHGIRLDKPDWSGQSHSLAFAWRNAALGEFRYVAINSFWNTLEFDLPPVAAGKSSGWLRVMDTSLGSPFDIADPGQYVSVSGSTYIVNPRSAILLRSDYTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E9</accession>
    <name>E8X7E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4436</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573102.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71383">
        <property type="protein sequence ID" value="ADW71383"/>
        <property type="gene ID" value="AciX9_4436"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4436"/>
    <dbReference type="HOGENOM" id="CLU_046640_1_1_0"/>
    <dbReference type="OMA" id="NERAEYG"/>
    <dbReference type="OrthoDB" id="466535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="52"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="227"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="45225" checksum="A36BDFF6A07EE708" modified="2011-04-05" version="1">MWEGCAVSHGYDFRSANEDELWERQVSDKQDENAEATDLIGPEGYGSIRNEIVGLLEAARAASIRSVNALMTASYWEIGRRIVEYEQRGDKRAEYGEELIKQLAGDLTRQFGRGFGAVNLSQMRRFYMEWPTQQIFQTLSEKSVPLSELASRFPLPWSAYVRLLSVKNPLARTFYETEALRSGWSVRQLDRQIGSQFYERLALSQTKAAMLEKQQIPSSEDLVTPEEAIKDPFVLEFLGLKDEYSESDLEEALILNLTDFLLELGDDFAFLGRQRRLRIDDTWFRIDLIFFHRRLRCLVIIDLKAGRFGYADAGQMHLYLNYAREHWMKPGENPPVGLILCAEKGASEAHYALDNLPNKVLAAEYKTVLPDERLFAEELERSRLKLDRRQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F4</accession>
    <name>E8X7F4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71388">
        <property type="protein sequence ID" value="ADW71388"/>
        <property type="gene ID" value="AciX9_4442"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4442"/>
    <dbReference type="HOGENOM" id="CLU_139085_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17526" checksum="A76B7C81D8B34DED" modified="2011-04-05" version="1">MLRGDIDCGVFYTGLANTILMLYNNHQKDPKHLINKYFHPNWRQNPMRRLSSIFRNNPATQSAFCSFRNLLPALAFLSVTAVAHAQGSVDLSGATTLMNTFKTFALYAGAVICLGSMIFAGIRLMGGRFQEAIPGLFGALFGAAVIGWGTGWISSLTGQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S7</accession>
    <name>E8X7S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4581</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4581"/>
    <dbReference type="EnsemblBacteria" id="ADW71511">
        <property type="protein sequence ID" value="ADW71511"/>
        <property type="gene ID" value="AciX9_4581"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4581"/>
    <dbReference type="eggNOG" id="ENOG5032UGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502322_0_0_0"/>
    <dbReference type="OrthoDB" id="1806884at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="553" mass="61824" checksum="FEC2BBD8954D256D" modified="2011-04-05" version="1">MVLPAISQRGLFALLYPNFFILCFIFSLVCVGVRFLLPRTWDTALGALTQSRWQLSIVSVLGLLYLYIGCLILRFPGYVDPVEPMVVAASFFSVHSKPVYDMVISYGPLCFLPYGLAMKLFGATVAVLKGVVGLANAVFILVLFVIFKKLFRWPSSLLATILVLSTCLMKQNYLFQARGDLFIYVAVALSLLAAISEGGALGCVLMIAAVTLGCGVKVTAFMYFVYPLSLFWQRHGSRLLLLVAAGSILLSFLPFALHTLNLHDYLHWLTVMSHQPKSIREFLGNVVITGLLLFPCLLAYWQLHRRHHSLARQFLRENWIPFSFMTGSILAMDVLASKIGAGRHHLVPYFVFTGYIVAQLIHKSRSGMPSSSSPGLLHVYLCGCLALLLLLTEVSELQDVRTLTRQEAAQSVALENDVNRVLASYSGHRVELGNGIGEFDLEREYSPMFSAPQLIFAGGSYTFDPSAQADIEMVNEPMRESDLRHVASCESDVWLIPRGQVPFHSVSIYSGMYPDRYSGRLLFPATFERMFLDTYSLTSSSHYFDIYTCKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X4</accession>
    <name>E8X7X4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VirB8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4628</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71558">
        <property type="protein sequence ID" value="ADW71558"/>
        <property type="gene ID" value="AciX9_4628"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4628"/>
    <dbReference type="HOGENOM" id="CLU_1037320_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007430">
        <property type="entry name" value="VirB8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04335">
        <property type="entry name" value="VirB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="VirB8" evidence="7">
        <location>
            <begin position="23"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="31752" checksum="91951D9AB477BF18" modified="2011-04-05" version="1">MATQTAPLTDAAWTPQQAMLTDQIANEVYASHYAERKTSRFVIGALSIALLGSLVTIASLSKKPLVNRYVRIDEMGRAQAIQYSDLQYSPREGEVRTYLTDWANYRFTLNKETVAKKYPLNYYFLSQPLAAQGMADDNTNHKISEVMSGQTEQSEVEVKNVTITAMSEETVQNVTLARGTALVNLDKLYSSRTSQAPRTEHWMLSVTYYINPAQVNQQSQRFPQFETINPLGLTITEFHESRIGFDSNNEKPAGSAFVPASPGRPIIPGTGSGVQAAPSMAAQSGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X838</accession>
    <name>E8X838_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71622">
        <property type="protein sequence ID" value="ADW71622"/>
        <property type="gene ID" value="AciX9_4695"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4695"/>
    <dbReference type="HOGENOM" id="CLU_130417_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234495" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19460" checksum="68E9D81211905E8C" modified="2011-04-05" version="1">MAFQHAKCRVRPKKQTIVAISLLSLAFATAVGENTGKPADIKQIQQLQKRYVASIDGADLALVDQVWSHSPDVIFVEPLGTERGLLQVEGFVRNTFGKMFSKRNLQLENPSIHVYGDTAWSEMTWTFDATLRDGEKPLVTKGRETRVLRKENGAWHIIAIHYSGLPVNGKLQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X840</accession>
    <name>E8X840_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71624">
        <property type="protein sequence ID" value="ADW71624"/>
        <property type="gene ID" value="AciX9_4697"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4697"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="IPGAQVQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234289" evidence="1">
        <location>
            <begin position="21"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="910" mass="97541" checksum="0C1A7B634F998DE5" modified="2011-04-05" version="1">MRCFLSYLSLVCLSVPALRAQSCPDTGTLSGVVFDATNAVVRGASVEAVGLDGSVRITSSGPDGRWTLLCVAPSVYRVEVGSQGFQSRETVALRVQINRVTTLSTQLQIASVTESLNVDGEDNAAKSGGSNVLTASQLDGLAEDPDDLQRQLQALAAASGGLPGSALITVDGFQSPSTLPPKSAIQEVRISPDMFSAEYEYPPYAGGRIEVFTKPGQDRIHGAIFGVLGSHVWNASDPFSTTGTPADKQREGFEFSGPLLSRKRADFALDLDHRSIDENAVVNATVLSTTGTPTLFNQTVATPQRLWLANARTGWQIGSKDTLAISFGANNNSTENKGVGGLTLQENGAFGRVSEYDLRAVNTTFIAKDLLHSTRVGFSWKTTEQTPNSTGPQLSIAGAFTGGGSSIGSLHNQERDLEFDDEIYLSLKRHTVKWGVQLLGAFINDANPDTFNGAYLFGGGSAPALDGSGATLNITGLEQYRRALAGLPGGRPTTYSQTSGIAEVPLEQWTIAAYIQDDWKLITRLSLSAGLRYFSQTAPNVSDGIAPRVGAAYAFGKKKTWILHARTGLFYAPVGSPISLETVRLDGQRQRSLTVYSPQYNDPFGTPASTPPIERQRRFEDGIGITPSSQSQLSVEQTFFKSWAVNANVYYTASWGVLRSFNANAPLIFSASNDPAAAPRPLAANLNLFEYGRTGRFAGPFAFLGVSHFAQRFSLISGCLYNGFRTNADNPNLFPQSTYEKSRDWARPTGSPTHSLFAVIIYSLPFKIGSTTNLSVSSGAPYDVTTGFDNNGDGVFNDRPSSVTATGTGVYATPFGLLSTNGVNGDLQRNIGTMPATIHLDLSLNRSFTFKEKHGSVLHQQTLRFDARAANLLNHANYTAADGIVGTPQFGRAVAADYGRRLEFGVRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV66</accession>
    <name>E8WV66_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0167</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0167"/>
    <dbReference type="EnsemblBacteria" id="ADW67241">
        <property type="protein sequence ID" value="ADW67241"/>
        <property type="gene ID" value="AciX9_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0167"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072546_0_0_0"/>
    <dbReference type="OMA" id="ITNWHNV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="29085" checksum="7B123856EDD8C1D8" modified="2011-04-05" version="1">MGSTLFTMQRIDPISTHSLLLRTYCRGRHLGIATGFVVLKNNVHYLVTNQHVVSGLNIWNDQPSHSDGLVPDSISILHHVRGHLGRWTAIKERLRSEDDRPLWIEHPVGKQIDIAFLRLTSFYDESLLCIATYPLDLAIRNTQIPLFPTSPVSIVGFPFGNGQLDGLPIWKSGSIASDPDIDYEGHPQILVDCIGRQGMSGSPVYARRIGGFTDVNGSFSISVGGAMTTDRFVGIYAGSIDKASEIGRVWKASAVLETYSTLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV86</accession>
    <name>E8WV86_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578589.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0187"/>
    <dbReference type="EnsemblBacteria" id="ADW67261">
        <property type="protein sequence ID" value="ADW67261"/>
        <property type="gene ID" value="AciX9_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0187"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="GFITMPG"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30965" checksum="8F7CE8B14BB8287D" modified="2011-04-05" version="1">MPQQPSPVWFITGCSTGFGRELAKLILARGGRVVVTARNPDQIQDLVAGHEANALALPLDVNDPAQIKAAVQYATEKFGQIDILVNNAGYGYLAAIEEGEDAEVRKMFETNFFGLVALTNAVLPGMRERRSGHIVNFSSIGGLVSFGATGYYHATKYAVEGMSESLAIEVAPLGIKVIIVEPGPFRTDWAGRSLPESKIVIPDYDSTAGERRRQTRARSGKQQGDPVRAAAAILKAIESDTPPLRLVLGKPALDLAYKKLESVKKDLDTWKEATLSVDFPEDEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ4</accession>
    <name>E8WVJ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1383</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579764.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1383"/>
    <dbReference type="EnsemblBacteria" id="ADW68442">
        <property type="protein sequence ID" value="ADW68442"/>
        <property type="gene ID" value="AciX9_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1383"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076058_0_0_0"/>
    <dbReference type="OMA" id="IFFTDTH"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233408" evidence="1">
        <location>
            <begin position="27"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="39"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="331" mass="36132" checksum="9130AA2C7C08B5E4" modified="2011-04-05" version="1">MSSLTRRNFLSLSAATSAALALPTSAYSLTLPAAPGNLRLIFFTDTHNQPELNANEGTTLAFAKIRSLKPDLCIQGGDHAFDLAAAPRDRSLMLLDLYQKTERSLDGIPIHHVIGNHDVFGRDPASNITLTDPLYGKKAFEQTFKTKTYRSFDQAGYHFILLDSIQITADRGFDAMIDDAQLAWLKSDLAATPIGTPIIIATHVPIVSAAPQYSPPDDKAATAIAYQQITHLHGFLLGNAPTVLPLFHGHNIIAVLQGHTHINEVVQWQGIPFITSGAVCGNWWRGSRWGTPEGFTVLELANGKAHWHYETYGWKATNPLPDPYASSPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ9</accession>
    <name>E8WVJ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="11">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1388</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579769.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1388"/>
    <dbReference type="EnsemblBacteria" id="ADW68447">
        <property type="protein sequence ID" value="ADW68447"/>
        <property type="gene ID" value="AciX9_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1388"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_1_0"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="7"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="462"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="589" mass="64980" checksum="1B96C091EDF91A97" modified="2011-04-05" version="1">MAATPRIIVVGGGLAGLAAVIKIAESGGIVDLFSIVPVKRSHSVCAQGGINAAKDLKGEGDSVLKHFDDTVYGGDFLANQTPVKNMTAQGPAIIDLLDRMGVPFNRTPEGLLDFRRFGGTLYQRTAFAGATTGQQLLYGLDEQVRRHESEGKVTKYEGWEFLSAVLDDNGVCRGICAMDLRSMETRTFPCDAVIICTGGNGAIFGKSTNSVVCTGSAQSALYQQGAFYANGEFIQVHPTAIPGEDKLRLMSESARGEGGRVWVPRDRNEKRVAKSIPEADRYYFLEERYPKYGNLVPRDIATREIFKIVYEDQMGIDGQPMVYLDLTHLPKERLHKLEGILEIYEKFVGDDPREVPMKIFPGVHYTMGGLWVDFDQKTNIPGIFAAGEADYSIHGANRLGANSLLSCIYAGLLSGPNAVAYAKSLPAQVGDGGHAAELARQKTLNNKLINNPGTENPFKLWRELGETMTKHATIVRYNAGLDEADAKIVELLARYKNINLSDKSQWANTSFAFTRQLYNMLELARVIVQGARQRDESRGAHYKPDFPNRNDEQFLKTTKAAFVDGAPKITYEEVDTQWIKPRPRVYSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL0</accession>
    <name>E8WVL0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2507</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580854.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2507"/>
    <dbReference type="EnsemblBacteria" id="ADW69539">
        <property type="protein sequence ID" value="ADW69539"/>
        <property type="gene ID" value="AciX9_2507"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2507"/>
    <dbReference type="HOGENOM" id="CLU_1123307_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26538" checksum="918E2F36AC4EB9CD" modified="2011-04-05" version="1">MATYLVVPDDYAGWNPTGRNFASIGAAIGAIGLLSWMSLHRHLGTFTPAATSDRLFLSGLVWLGAGGFGLMAVAAMGSILLSLKSRGTVTITDQGVLRTVGTRSSSLPWTEIQGLVPMPYGGVTLVATTGKSNITIPRFLDDYRACIAELKDHGLQAIPSSSLRTKRKRNWQNTLTVGAFVFFISLATSAHESHSVRITSLSAAVALAVWALKTAWTKTELEASPWLDCVVLLGILLYASIRMILTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP2</accession>
    <name>E8WVP2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580886.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2541"/>
    <dbReference type="EnsemblBacteria" id="ADW69571">
        <property type="protein sequence ID" value="ADW69571"/>
        <property type="gene ID" value="AciX9_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2541"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_7_0"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="35365" checksum="E3FECBCD6270FAC9" modified="2011-04-05" version="1">MQAAIFRHSAKDTKPYLSIEDVPRPTMLPGHSLLRMIACGVCRTDLHIVTGELPALRTQLIPGHQIVGEVVDGATPNFPIGMRVGVSWMGGVDGTCWYCMHSAENLCDEPVFTGYTVDGGYAEFVLVRTDFLLPLPVGLDDAAAAPLLCAGIIGFRSLRVAGVEPGEKVGLHGFGSSASLAIQVLHSWNCEVYVSSRGQGNRDRAAALNATWVGKDGDKPPVALDRAITFAPSGEVVIAALSALRKGGVVAVNAIHMAQIPAFDYDSLLWGERQIRSVANMTRADARDFLEIAHTLGIRPKTTVLKLEQANEALAMLSRDRDDSSIVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR0</accession>
    <name>E8WVR0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2562</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580904.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2562"/>
    <dbReference type="EnsemblBacteria" id="ADW69589">
        <property type="protein sequence ID" value="ADW69589"/>
        <property type="gene ID" value="AciX9_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2562"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025944_0_0_0"/>
    <dbReference type="OMA" id="HMPGAGD"/>
    <dbReference type="OrthoDB" id="908898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="32208" checksum="4F21FD158A5FFCBF" modified="2011-04-05" version="1">MTSINHAVATKDDEGHTAEIPRLLLVDDNEMVRLTLAKILEGGGFNVATAQSVNEALKLIGSQPFDALLSDLHMPGAGDGLTVVSAMRHFNPKAVTIIFSGFPEMKEAAAAILLQADEILVKPMSPDVLIQTIKDRLKAGANAVGRVTQTVAFLLEEDTQITIDDWLLRVNLEPDVITVRLSTEKRCAHLPHLFRDLITRLRKPLPLGTRALPSAAAVAHGLARREQGYTAAMIVEESRMLQVSIFQTLQNNLHRVDFSLLLLAVMAIADEVDSQLAQTMASYIAEAKVDLLPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW02</accession>
    <name>E8WW02_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0234</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578636.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0234"/>
    <dbReference type="EnsemblBacteria" id="ADW67308">
        <property type="protein sequence ID" value="ADW67308"/>
        <property type="gene ID" value="AciX9_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0234"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_0"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="18041" checksum="FBAE96274AB46F89" modified="2011-04-05" version="1">MPAPTQPNDIVENFTLPDQDNTPITLSDYATHPVVLFFYPRADTPGCTIEACSFRDAISDIQATGAVVLGISRDTVKAQKKFAEKFHLKYPLLADADEKVCDYFEVIKPKNMYGKLVKGVARNTYLIAPADKEGHQRLLKVWEKVKPEGHAEEVLTYLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF4</accession>
    <name>E8WWF4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2593</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580933.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2593"/>
    <dbReference type="EnsemblBacteria" id="ADW69618">
        <property type="protein sequence ID" value="ADW69618"/>
        <property type="gene ID" value="AciX9_2593"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2593"/>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065784_0_0_0"/>
    <dbReference type="OMA" id="CFADCVP"/>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="264" mass="28159" checksum="AC1408FCE14D8B3C" modified="2011-04-05" version="1">MVIPVLRATGWDQIPGLRHGFSTRIGGVSQIYTGGQQGELNLGLTADDERDRVLANRRLLLQTLGGDRWDGAEIKTVRQIHSARIERVDAAYTPGSVEADGLITNQPGVMLGILAADCVPVLVADVQRGIAGAFHAGWRGTAARIVEIGVAQMVDELGAKVGDLVAAVGPSIGSCCYEVGPDLQKTFSQEFEYGSELFSRGTHLDLWEANRRQLLAAGLAPEQITVIGECTACSRINGARKYFSHRAEAGFTGRGMGIIGFDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT8</accession>
    <name>E8WWT8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'(3')-deoxyribonucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0344</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0344"/>
    <dbReference type="EnsemblBacteria" id="ADW67416">
        <property type="protein sequence ID" value="ADW67416"/>
        <property type="gene ID" value="AciX9_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0344"/>
    <dbReference type="eggNOG" id="COG4502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111510_0_0_0"/>
    <dbReference type="OMA" id="FNAKFRW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="21362" checksum="996CC6946CA116C0" modified="2011-04-05" version="1">MSDAPKKRICIDMDEVIADAVAEHVMRYNRDFNENVTLADLEGKWLWDVVQLDRHPALEAHLRSEDFFAVLNVMPDSQRVIKALQERYEVFIATAAMEVPTSFMAKYNWLARHFPFISPSHIVFCGDKSILQADYLIDDNPRQLRRFHGEGILFHSPHNMHTPGFRRVHNWQEVEDLFLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ3</accession>
    <name>E8WWZ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase subunit III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1501</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579874.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1501"/>
    <dbReference type="EnsemblBacteria" id="ADW68554">
        <property type="protein sequence ID" value="ADW68554"/>
        <property type="gene ID" value="AciX9_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1501"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_4_1_0"/>
    <dbReference type="OMA" id="CARYWHF"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="61"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="28876" checksum="788ACD40B185C9C6" modified="2011-04-05" version="1">MPAVITPNEIERKRRDLEDGDHGGGRRPPTDKRTGGGGDPDNWNDRRRGRRSPRERLDRYRLGLFFALSAVFMFFVAIVSVFFVSQGSGHFDANARFINEWLPTAIPPLLWLNTLVLVLSSITVEVARRHMFREMDVMDEWLGLGKPTSRRAMPWLVATVVLGCVFLVGQVVAWRQLGAEHVFYNSNPSSHSFFLITGIHGFHLVVGVLALFAALLGLGLSKVVENRQIMVDCAAWYWHSMGILWLGLFALLALFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX12</accession>
    <name>E8WX12_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1520</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579892.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1520"/>
    <dbReference type="EnsemblBacteria" id="ADW68573">
        <property type="protein sequence ID" value="ADW68573"/>
        <property type="gene ID" value="AciX9_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1520"/>
    <dbReference type="eggNOG" id="ENOG5032RZ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2666340_0_0_0"/>
    <dbReference type="OMA" id="EAWGFEI"/>
    <dbReference type="OrthoDB" id="1879010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8775" checksum="8860BB582B5AF8B0" modified="2011-04-05" version="1">MAKRRGNPNWGKPEPIGPVVPTVTSFEQVVKEYKLTPDQYIRSTRLREWARRNKNSKYIPEALLEAWGFEIESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX55</accession>
    <name>E8WX55_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2673</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581012.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2673"/>
    <dbReference type="EnsemblBacteria" id="ADW69697">
        <property type="protein sequence ID" value="ADW69697"/>
        <property type="gene ID" value="AciX9_2673"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2673"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_0"/>
    <dbReference type="OMA" id="FKIHTFS"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="541" mass="58761" checksum="A22E7E18FC92C7AE" modified="2011-04-05" version="1">MATAVAPISQISPVEALRRAGINPWVVALTVTLATFMELLDTSIANVSLPYIAGGLGRSFDEVTWILTTYLVANAVILPMSAWFSRVFGRKNYYMACVALFTVTSFLCGIAPSLEIMLLARVLQGIGGGGLAPVEQAILVDTFEPAKRASAFALYTVAIVTAPAIGPVLGGWITDNYNWRWVFLINIPIGLLSLYLTNRFVFDPPSYAAERASVRQGGKLSIDGVGMALIGVGSAALEILLDRGQIDDWFGSVFIRWCFVVGVACLTGAVFWELNHKDPVIDFRLLKVRNFALACVFYFTFGVGLFASTTMIPQLLQSLYGYRAIDAGLVLGPGALVITFLAPVGAQLVQRGIVKPKILLFGAVMVVGLSFIHYSHFNLATDYKHYALARALQGFGYAFFFVPLSVIGYSQLTPAQNNRASSLTNFFRNWGGSFGIAFVTTMSERRQDFHQSIVGANQNASSATFQSAVNATAAYLRVHGFSQADALSAAYARYYNELFAQTRLLAFMDCFYVLGIMTLVVGPLALLTKSFKPSAKSEPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX65</accession>
    <name>E8WX65_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="8" type="ordered locus">AciX9_2683</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2683"/>
    <dbReference type="EnsemblBacteria" id="ADW69707">
        <property type="protein sequence ID" value="ADW69707"/>
        <property type="gene ID" value="AciX9_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2683"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_0_0"/>
    <dbReference type="OMA" id="QDSICLL"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="36781" checksum="7638CC2149F691BF" modified="2011-04-05" version="1">MLALPSVGLKVGERVCCAVSGGADSVAMLLLVCAANGGSKGLGLGVSAVHVNHGLRGAESDGDEGFVAALCEGLGVPLTIERADVAGRVAARGETVEEAAREVRYECFRRLIAEGRANVVLTAHTLDDQAETVLMKLLRGAWTEGLGGISPVVEVPGGRVVRPVLGVRRGELVEFLKAKGQGWREDSSNADEAFTRNRLRHTVMPVLRAENPSVDRTLANLAEVAREEEARWGVELKRLLPQVLLPGKPVRGGGRANSTAVDGGAVAIEIERLRAMDGALRRRVLRAAARGIGARLSFDETGRLLALAGIGPADPTVPTKAGSVLKLANGLVGERSVRELRLSRAGSGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX80</accession>
    <name>E8WX80_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2698</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581037.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2698"/>
    <dbReference type="EnsemblBacteria" id="ADW69722">
        <property type="protein sequence ID" value="ADW69722"/>
        <property type="gene ID" value="AciX9_2698"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2698"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="KHSYGIG"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="185" mass="20981" checksum="9F6A7BB47CCA47BD" modified="2011-04-05" version="1">MASVEGYSLELPVVERARSEQADLAALVGTYSGLLFRIAHSVLRSRHEAEEVVQDTFVRVLEHRRELPGVRDVRVWLIRIAWNLALDRRRKIRPEQLDGVFAESLAARNVPADRALHDAQRMKVVLAEMERLPKAEKHVLLLSAVEEMGTSEMAEVLGKSESAVRALLFRARTRLRERLEKGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA1</accession>
    <name>E8WXA1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2719</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581058.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2719"/>
    <dbReference type="EnsemblBacteria" id="ADW69743">
        <property type="protein sequence ID" value="ADW69743"/>
        <property type="gene ID" value="AciX9_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2719"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_0_0"/>
    <dbReference type="OMA" id="IVMESKT"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="722"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="781" mass="83920" checksum="E36CA6CF858BC26C" modified="2011-04-05" version="1">MQPNNAPRQPRQTLTAPIQRKRFAYVALAFIVWMLAIALRLVWLQVYQNHKWVSLAARQQQGSFEVAPRRGVLYDRNLKELALTVQVDSIYAVPSELGENREEASQMLARLVHTDPTDNFTSQHQMNARFNASHGFAWVARRVSAETAQRVRELNLKGVYFQKEFKRFYPNNELAAHVLGYVGTDDAGLGGLELQFDDDMHGVSGHMLTALDAKRHALGSTENEPQPGENLVLSIDANIQYMAEKALDEQMAKVKAAHGTVVVQDPHTGQILALAVSPRFNPNDAKHMDASVLQNLAVSDIYEPGSTFKLVTYSAAMDGAGVEPTDIVDCMGGAMTMMGRTLHDDKSDGRMGRVTVQYALERSSDVGAAKMAMKLGNQKFYDYMKSYGFGDRTGIELPSETRGLLRAPKKWDATSFMSLAIGQEIGVTPIQLATMVSTIANGGMYMPPHVLLQSTDEMKGDPRLKPAAFHPANQLPTVLPDGAHRVIKEITSAKMREMMRGIVVEGTGKAAALNGYSSGGKTGTANKIDPATHTYSHTKLVASFAGMAPISNPAITVAVIIDTPTVGSLYGAAVSAPVFASVAQQVLEYLGVPHDQPLKTQKEMQVAAAQAKDDFDGDAADNGADLNAMFADVNSLPADDPLRGGTEKPVLAVAAPVETEEEKRSSGLKSLLPKSVLEAFHANGSTTSVIADESANADRPLAAPKVVPVVQALTNGGVRVDAGQRVAVPEFSGIPLRAVVERAGAAGLRVQPVGSGLATEQVPLPGTMVPVGTEIVVRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB6</accession>
    <name>E8WXB6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0377</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578777.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0377"/>
    <dbReference type="EnsemblBacteria" id="ADW67449">
        <property type="protein sequence ID" value="ADW67449"/>
        <property type="gene ID" value="AciX9_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0377"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="ADRANDW"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="26184" checksum="C0678AB8AE6D57CC" modified="2011-04-05" version="1">MNNDLGHQTLEPLHAPIVNAPIIEVRNLIKTYRAGEVDVNALNGVSLDVARGEFLSIVGTSGSGKSTLFNILGGLTPPTSGSVSINGRDLSHMTDTQRNDLRKRTVGFVFQKYNLLPTLTAEQNIQIVRDVAGRPTAFDDQFREILAMLGIDKRMSHKPRALSGGEQQRVAIARAIVNGPAILLADEPTGNLDSKNSDVVLTLLRDLNKRLGQTILMITHNPEAAAYADRTIQMRDGKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC0</accession>
    <name>E8WXC0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0381</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578781.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0381"/>
    <dbReference type="EnsemblBacteria" id="ADW67453">
        <property type="protein sequence ID" value="ADW67453"/>
        <property type="gene ID" value="AciX9_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0381"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_2_1_0"/>
    <dbReference type="OMA" id="YITHYPL"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="42143" checksum="FBE62190929D4C03" modified="2011-04-05" version="1">MNQAGGKLKEKSHYEILDGLRGVASLMVVCFHCFEAFADENRFKQIINHGYLAVDFFFLLSGFVVAYAYDDRWGRMTQWEFYKRRLIRLQPMVIAGSVIGAALFYFQAGPLWPMIATVPVWKMLLVMLVGFTMIPLLPSMDIRGWHEMHPLNGPAWSLFFEYVANILYAVGIRKLSNKALGVLVTLSGAFLVQYLVWGPKGDVIGGWAVDHTQLHIGFARLLYPFFAGMLLMRLGKRIHLRGAFLWCSLLLVALLAMPRIGGPEHLWMNGLYEAACIVVLFPVIVAMGAGDQVRGRFAIKLCKFFGEISYPLYITHYPLIYIYTAWAIKNKVPAAQGAVVGVGLVVTAVAIAYACLKLYDEPVRKWLQRTFSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ1</accession>
    <name>E8WXZ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0458</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578858.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0458"/>
    <dbReference type="EnsemblBacteria" id="ADW67530">
        <property type="protein sequence ID" value="ADW67530"/>
        <property type="gene ID" value="AciX9_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0458"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_0"/>
    <dbReference type="OMA" id="PFQWTGG"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="16"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="543" mass="61828" checksum="8D6630BD4AB2ACDB" modified="2011-04-05" version="1">MSEHCKLWWRDGVIYQIYPRSFQDSNGDGVGDLAGISSRLDYVATLGVDAIWISPFYPSPMADFGYDVADYTGVDPLFGTIDDFDALLAGAHARNLKVILDFVPNHTSDQHPWFLESRSSRDNPKRDWYLWRDGNEGRVPNNWMSNFGGTAWTYDEITRQFYYHSFLTQQPDLNWRNPEVRAAIFAAMRFWLDKGVDGFRMDVLWLLIKDDQFRSNPPNPDFNGGSSFWSILPTYTADQPETHEIVRQMRALVDEYSERVLIGEIYLPIDELVRYYEPGDTASSGYLETPHLHGAQLPFNFHLIQTAWQADLIAELIRSYEAALPPGAWPNWVLGNHDQHRLATRIGAAQARVAAMLILTLRGTPTLYYGDELGMTDATITPDQVQDPAEKNQPGQGFGRDPERSPMLWDETPNAGFTSAPTPWLPLVDEHVRISVTAEEAAPRSFLHLYRALLTLRSATPALHCGTVTEVISPSEVLTYTRAGEAERYQIHLNFTNETKWIDSPKGTLILSTYLDQQDRPWIEWMQLRPNEGVVIKLNESPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY28</accession>
    <name>E8WY28_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bilirubin oxidase</fullName>
            <ecNumber evidence="3">1.3.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0495</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0495"/>
    <dbReference type="EnsemblBacteria" id="ADW67567">
        <property type="protein sequence ID" value="ADW67567"/>
        <property type="gene ID" value="AciX9_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0495"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_4_0_0"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047705">
        <property type="term" value="F:bilirubin oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="441"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="568" mass="63958" checksum="07ED4635BE972D8B" modified="2011-04-05" version="1">MLSRRHLLRHGLHTAAAATFARGASLLGQTVMASPPQVRSGVKLQRYADALPIPSVLHAPSDETQALEIEIRQTKQKVHRDLPPTTVWGYNGSWPGPTIEAHRDHPLKVNWVSKLPTTHLLPIDHSICGAEASMPAVRNVTHLHGACTLPEDDGYPEAWSTAHGEHGPTYRPGPATYPNCQPSTTLWYHDHSLGITRLNVYAGLSGFYLIRDEAEKALNLPQGEFEIPLMLQDRLFHRDGSLYYPKVVNGPKEHPVWVQELYGDMNCVNGMVMPFLEVEPRKYRFRIVNAANSRFYHLRLFNSDSTGKVLNQSYEVPSFQQIGTDGGLLPAPVELHYLLIGPAERFDIVVDFSGCEGKSFSLLNDAPAPYTMGGQYLAEDVMLFKVAKPLSGKDTSTVPDVLVPFEYLKPSFDTRERMLLVSEKERPSDGYVITGLLGNAQWHDPITEDPKAGSTEIWSFVNTTSDVHPLHIHLVQFQVLNRQSFDVKTYQQTGKIIFTGKPMAPESNERPARKDTIKSYPGYITRVIQRFDLPHGMYTPGQELIYVWHCHILEHEDNEMMRPYKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY77</accession>
    <name>E8WY77_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1652</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580023.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1652"/>
    <dbReference type="EnsemblBacteria" id="ADW68704">
        <property type="protein sequence ID" value="ADW68704"/>
        <property type="gene ID" value="AciX9_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1652"/>
    <dbReference type="eggNOG" id="COG2952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163266_0_0_0"/>
    <dbReference type="OMA" id="RVILEAY"/>
    <dbReference type="OrthoDB" id="1875579at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10736" checksum="B1B3ADDE5FC72D23" modified="2011-04-05" version="1">MIFSKDYVGYLARQTVKHLVSEKMIHSDKVGVLNERVTNSMIEELALEDRINDEVRVILEAFQEDMRKTGASYPEMFKKVKNELARKYKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY95</accession>
    <name>E8WY95_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1672</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580041.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1672"/>
    <dbReference type="EnsemblBacteria" id="ADW68722">
        <property type="protein sequence ID" value="ADW68722"/>
        <property type="gene ID" value="AciX9_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1672"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_16_2_0"/>
    <dbReference type="OMA" id="INNQIGA"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="45121" checksum="80D1C92409B9D6AB" modified="2011-04-05" version="1">MDISRPDLKRQKRRRNFLYAASFIAVIAVVGFLILRLKPAIPTVDGPVWTDVVKRGALLRQVRGPGTLVPREDRIRLIPAETEATVIRIRVLPGAKVEPDTILMDLVDPEVQQEMLDAGLQLKAAEADLLNVKARLRSDLMTQQAGAATVSADQKQAALQSQTDKSLYDLGVISGLTYSASKGKADELSQRNDIEHQRYDLNEKAIATQVAVQQTKVAQAQAMLGLRQKQQAALSVRAGIAGVLVDLPHQVGEHVAIGTTLAKVVQPDQLKASLKIPETQARDIQIGQPSEIDTHNGVILGKVMRIDPAVQNGTVTVDVELAGALPQGARPDLSVDGTIDLDRLSDVLYIGRPAVGNENSTISLFRVDADGKTATRVSVKVGRASVNSMEVLSGLNAGDSVILSDMSKWDSTDRVRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC0</accession>
    <name>E8WYC0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2803</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581141.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2803"/>
    <dbReference type="EnsemblBacteria" id="ADW69826">
        <property type="protein sequence ID" value="ADW69826"/>
        <property type="gene ID" value="AciX9_2803"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2803"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903755_0_0_0"/>
    <dbReference type="OMA" id="PSQFCGC"/>
    <dbReference type="OrthoDB" id="2153375at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="15160" checksum="5C072768E5979917" modified="2011-04-05" version="1">MKRILEQEQGSSLLEAAILMPVLLFALAGSVDFGHLFYLRMALSSAAAAGAAYGTQHPSDTAGMISAVQLDGSDVPNLTAAASYGCECADGTLASAACTTVPTCPVNVINYVDIQASYNYSPLIAFVGIPSTFPLQERARMRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK9</accession>
    <name>E8WYK9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578935.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0535"/>
    <dbReference type="EnsemblBacteria" id="ADW67607">
        <property type="protein sequence ID" value="ADW67607"/>
        <property type="gene ID" value="AciX9_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0535"/>
    <dbReference type="eggNOG" id="ENOG5033DXD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206044_0_0_0"/>
    <dbReference type="OMA" id="VVCWPLA"/>
    <dbReference type="OrthoDB" id="2076697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="7048" checksum="928AD006E83651F9" modified="2011-04-05" version="1">MLKLLVFLILVVCCWPLAVVAVILYPFIWLVLLPFRLVGIVVEGVFDLIAAIFLLPARAIRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS1</accession>
    <name>E8WYS1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1709</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580076.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1709"/>
    <dbReference type="EnsemblBacteria" id="ADW68757">
        <property type="protein sequence ID" value="ADW68757"/>
        <property type="gene ID" value="AciX9_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1709"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_0"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="112"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37357" checksum="9BDB5608E94112AC" modified="2011-04-05" version="1">MTDDPLNTMTSISKAPAVTNFVAAAEPIPPDQNGPPSVVREYLRTRGSGRVADSAFSAAMLICACSIFAIVIFIASILILRSKLSLAQFGFKFFSSQDWDPVSGSFGALPFIFGTLATSFLALLIAVPLALGVAVFITELCPKALRAPISFLTELLAAIPSVVYGLWAVFVLVPLVRDNIGPVLLKYLGWTGFFEGPNFGVGLLTAGIILSIMILPIISSLTRDIMLSVPNHQREAMLALGATRWEMIRTGVLRNARIGIVGAVILGLGRALGETMAVTMVIGNHPVISKSLFAPGYTLASVIANEFAEASGDLYLSALIEIGLALFLVTIVVNALARLLVWAVTRGAPGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX3</accession>
    <name>E8WYX3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1761</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1761"/>
    <dbReference type="EnsemblBacteria" id="ADW68809">
        <property type="protein sequence ID" value="ADW68809"/>
        <property type="gene ID" value="AciX9_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1761"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_0"/>
    <dbReference type="OMA" id="CIGIEPL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="2">
        <location>
            <begin position="41"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="388" mass="41907" checksum="F1930CA891571C64" modified="2011-04-05" version="1">MKARTGLPIGEPEGGETSVVSPRHGVSGGLKLKAAQDTKWDLVSLGEVMLRFDPGEQRITRTRNFRVWEGGGEYNVARGLRRCFGKRTAIVTALVDNPVGRLLEDLMLEGGVDLSHVLWSAYDGVGRESRNGVYFLERGHGVRAGMGMMDRGHTPISQLRAGQVDWDVIFAREGARWFHTGGIMCALSAESPAFVKEAMEAAKRNGAVVSFDCNYRASLWKEQGGRQGSIDVNRSLMPYVDVLFGHEGDIAAVMGESSHGPPWHDEASFAEMSARVVSEFKNVKVIATTTRRPKTATRNDWAAFGYAEGSVYKSKDYLDLDILDRVGGGDSFAAGLIYGLLNGKGMEWALDCGVAHGALAMTTPGDSSQATLAEVEKLMSGGGAGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ08</accession>
    <name>E8WZ08_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581238.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2900"/>
    <dbReference type="EnsemblBacteria" id="ADW69923">
        <property type="protein sequence ID" value="ADW69923"/>
        <property type="gene ID" value="AciX9_2900"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2900"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_0"/>
    <dbReference type="OMA" id="IMMGPGS"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="105"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="43829" checksum="5BC443CB820FDE52" modified="2011-04-05" version="1">MSSPLSLPGVSRRSFMRMASIAAAVPVFTEAHFARAAMLQQAANQTVTTVHHPRAAMPADAVLINANENPLGPCKAACDIIAAIAPKGGRYDIDGETGKLTKTFAEQNNIPEDHIMVYAGSSEPLHFSVLAFTSPSKSFVTADPSYEAGMRAAMVTKAKVVKVPLTKTYAHSRDMATADPNAGVIYICNPNNPTGTITSREDIDYILANKPAGSILLIDEAYIHLSDGQSAMEHVAAGKDVIILRTFSKIYGMAGIRCGLALGRPDLLAKMQPYGQNAMPITGSAAANVSLLDTDLVPTRKKIIASTRNDTFAWLTANKYDFIPSQSNCFMINTGRNGKSVITAMQQEKVWIGRTWPVWPNTVRVSVGTPAEMAKFKVAFKKVMDAPATAANVMHDHANDLNTRYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ51</accession>
    <name>E8WZ51_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0582</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578981.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0582"/>
    <dbReference type="EnsemblBacteria" id="ADW67653">
        <property type="protein sequence ID" value="ADW67653"/>
        <property type="gene ID" value="AciX9_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0582"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_5_0"/>
    <dbReference type="OMA" id="HDLYPYD"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="42134" checksum="8563861212D88633" modified="2011-04-05" version="1">MRVLIPMVSGGAGPDGVGRHAINVVRCLLRLDEIKAVDLVVGRWQLSYVESLLGATDPRLKLLVAETGRSSPARNLWYYNRLPGLAKERRSSLIHVTYPVPLHQRGLPCPVVVTLHDLYPYDVAANFGYPKVLINRLILEQCLSAADAIACVSDSTLERLMIRRPALRGKSLRVYNCVEPHTACSLDVQESKPCRPFILAVSQHRHNKNLPLTLAVFHRLLRADPSLMLVLVGRQGPETSALKASLESSGLASSVIMLESISEDNLQWYYRNARCLLATSINEGFGLPVAEAMLAGCPVACSDIAAFREIGDGYCSFVSLGAAQEDGFVAAFHQMMKQPRPVPATMPQLSSGSIAGRYAQLYRGLLDATAQGVETALQFSRENGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ64</accession>
    <name>E8WZ64_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0595</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578994.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0595"/>
    <dbReference type="EnsemblBacteria" id="ADW67666">
        <property type="protein sequence ID" value="ADW67666"/>
        <property type="gene ID" value="AciX9_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0595"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465241_0_0_0"/>
    <dbReference type="OMA" id="SMKIGAS"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="368"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="604" mass="65622" checksum="EDD05D157FA21804" modified="2011-04-05" version="1">MRSLLLVSLLALSFGLTAVSLVAVRFTLHRQIQRDLSSDLQHSVDTFLNLENQRREMLARETALLADLPSLKALMTTQDARTIQDGGKDFWEISGSDLFQLYDRSGHLVASYRRGLTDTGKPGSGETDAALHEAIELPDQPGTLPIGGKLYEVVAQPLSFGSRVDGTFLGYVVLGSAIDQRVAQEVSQAAAAEVAFTIGAKVAVTTLKAPLAKDFDGNLTLRGLQPGQMANVTLGNERYLAKAMTLCANGCTMPNKVHLVVLRSYESERRLGLVINRWLVGLGMLALVLGTLIADSISRRVTRPLEALVDGARALGRGDFTYKLPGGGTAEIRELTRAFDHMRGGLETSQRALVDSERLATIGRMASSISHDLRHYISAIYANAEFLSLEATPQVEREELIFEVQTAVHGMTDLLDSLLGFSKTGRSLLPSYESIPYLVERAAGLLRAHPEARAIELRLDELPSVEAWVDATKFVRAVFNLLLNACQAARRGGLVPAVTVELSEDEKRIVLKIIDNGLGVPASFATTIFEPFVSTGRENGTGLGLTLAQHIAQEHGGMVRLEESAPGRTVFTLSLYKEALNRLRETPVAVALKAGSQETAWRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE6</accession>
    <name>E8WZE6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1786</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580153.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1786"/>
    <dbReference type="EnsemblBacteria" id="ADW68834">
        <property type="protein sequence ID" value="ADW68834"/>
        <property type="gene ID" value="AciX9_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1786"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_1_0"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="464" mass="50562" checksum="ADF9A2DFD3FCF76D" modified="2011-04-05" version="1">MIESHKLRCTGCATEISGPNAPSDFRCPLCKNLYEVIYPWSIKGTQKEGVAAASLPNASALRWLWQERRTSTMPVDQSGVWRFRDLLPIVTDMNKVTTLREGNTPLYELPKSAKALGLHWVLAKHQGMNPTGSFKDTGMTAALSVAVERGFEWVACASTGNTSAAMAAYAARAGLRSIVFIPEGKIAWGKLSQSMDYGALTVQLKTDFDGCVRLVNELVRAYPIYLLNSVNPYRLEGQKTPAFELLEQLEWQVPEHVIAPGGNLANASALAKGFAEAHQLGLIPRIPKISIIQAQDANPLYTFMHQPGGTDGRELIPVTAETRASAIRIGNPASWRKAVNALQTTGGWCEEVTEQEIALAKAQIGAEGIGCEPASAVTLAGLKKLVADGRVKEKDRAVLILTGHTLKDSDYTIQYHRNELFTNQETAALTPEEAAQHTHLRKPPIVLEANRETVLSALEAQMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS4</accession>
    <name>E8WZS4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579063.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0665"/>
    <dbReference type="EnsemblBacteria" id="ADW67735">
        <property type="protein sequence ID" value="ADW67735"/>
        <property type="gene ID" value="AciX9_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0665"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_0"/>
    <dbReference type="OMA" id="YRNIPEW"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="36963" checksum="60E51A7781365256" modified="2011-04-05" version="1">MIVAMQDQATEENVQQVIERMVELGFNVHRTTGTTQTILAGVGSPDHFDVAEFQVLSGVHEAYRISSQYKLAGRSFRPEGTTVTFKNGVVVGGNQVTIMAGPCSVESREQILLSAKQVAAAGCQFLRGGAFKPRSSPYSFQGMGLEGLKLLREVADETGLLVITEVMEISQIELMLPYIDCFQVGARNMQNFNLLRELGHVRMPVLMKRGIAATIEEVLLSAEYILSGGNYDLMVCERGIRTFETYTRNTYDVSAIPVLKKLTHLPVFGDPSHGVGKREFVPAMALASVAAGADGLLMEMHPNPDKAMSDGAQSLFPEQLEKLVAQLRQLAPIVGRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU6</accession>
    <name>E8WZU6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579085.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67757">
        <property type="protein sequence ID" value="ADW67757"/>
        <property type="gene ID" value="AciX9_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0687"/>
    <dbReference type="eggNOG" id="ENOG50305QZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711259_0_0_0"/>
    <dbReference type="OMA" id="FVGPMDH"/>
    <dbReference type="OrthoDB" id="1181841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="417" mass="43982" checksum="48DD37B502094C2A" modified="2011-04-05" version="1">MSAEQNVVDAPTEQRAGHDSGDNSGDNGGQQYEMDENGQRVPHGMGQSKSSRRRRRKRKGKGPEAGGAEGSEQGSGDSGSNGEAGVIASVQAGAAAPAAPQNGGQNNGRSFQQNRGFQNNGGQNNGGPAGQGAAPGGTKRWKKKFRDRGPRQENPGNQQSAGGGGGFSQNNGGGFSQNNGGGGGFRDRDTHQPGNNVGGGGFKRKGGFGGSGGGGKQQQRGPRSFVGPMDHSYRAVNGNFTETPPSTIEPHGSFGGHAPRRGYQGDSQPIDYSQGRTIPIPDDAPTHIYFFIEDLFFIAKIQETARKLGVKVAFVKNDKESLATVTAAHEDERQSLIVFDLNNANAKPLTLIPKLKTKLKKTVSIIGFLSHLQGDLKAKAVEAGCNTVMPRAAFSQNLPNLLRRYGIEEVEEANYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZY7</accession>
    <name>E8WZY7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1836</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1836"/>
    <dbReference type="EnsemblBacteria" id="ADW68883">
        <property type="protein sequence ID" value="ADW68883"/>
        <property type="gene ID" value="AciX9_1836"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1836"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764481_0_0_0"/>
    <dbReference type="OMA" id="PHVHNSG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="434" mass="48406" checksum="D666922B4F2A97FF" modified="2011-04-05" version="1">MLADFLRDIGIRQPVYPCVGSRVNGCIIVYRVVVAPKPSTASFFSKGQPMKFCVLLQFALSATVLFSPLSHAQQSPRWPEQQANDWYAKQPWLVGANFIPSNAINELEMFQAATFDPAKNDHELGLAESLGMNTVRVFLQDQLWQQDPAGFKKRLDTFLTIAAKHHIRPLLVLFDSCWETDPHLGPQHPPIPGIHNSGWVQSPGKARLLDVGVEPELKAYVVGVVGAFASDSRILGWDVWNEPDNGGGDKAEDVPAKVRRVNQLLPKAFAWARSAKPTQPLTSGVWTGDWSDPGKESETTKIQLAESDVISFHNYDWPEGFEARIKELQPLHRPIICTEYMARGAGSTFDGTLPIAKKYNVAVINWGLVAGKTQTYLPWDSWQRPYVLIQPTIWFHEVFRNDGTPYRQHEVDLIRQMTGRGTAPSVPSTAGASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X009</accession>
    <name>E8X009_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid adenylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580224.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1859"/>
    <dbReference type="EnsemblBacteria" id="ADW68905">
        <property type="protein sequence ID" value="ADW68905"/>
        <property type="gene ID" value="AciX9_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1859"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_13_0"/>
    <dbReference type="OMA" id="IISPQAF"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1366" mass="150101" checksum="710A3B9D0EE98F0F" modified="2011-04-05" version="1">MLSDLAEDLGMVLKESSVHDPANSVTPAADAAGEVYAMPATQGEVRFWSLDQLNPGNPALNMPLMWQFTGQLDVPVLVEAFAECVQRHETLRTTFEVIDGKLSQVIQPEMEIPIPVVDLSGLTGEAQRAAADELTRDHAAFRMDLKTGPLLLLKLLKFNDQRHLLLVTMHHIICDGISNGILMRDMVTYYEALLKGTAAKLPELPIQFADYAIWHEEWRAGDEPEASMKFWRKALGNDFKKLELAHDVDACEALPPERRDITGDIETLLIPRDLTARAHAFCKRENVTLNILLFSIFCGLMSRLTGQKDLTIGSPCANRNEDTENLIGLFMNIQVLRVRLEQSSSFRDLLRQVQAWTLGAYENQALPFEDLVHDAFFSQTGSAFEIPIFFLYQKSFMLVTKIESAAGSLEIIPLRSESPGAVFEVMFAIVDRDEEGPRLQLEYNPQEFKASTIQRYLRLFVNLLESALDGPETLVDELDLLSGVERQRLLGGPNATTVDFGAFEPVHACFLRRATAEPERIAAECDGRSWSYGELAEFSTALAKRLIDEGLQPGGLVGVCVSRSLEMLGSVLAVLMAGGAYVPLDPRFPRERLQMVLADSGASLLLTGRDLKLDTTAKEIEITAETLTRQSDAVLPGMSGPDALAYVIYTSGSTGTPKGVAIEHGALMNLLRSMERTPGLDADDVLVAVTTISFDIATLELLLPLITGVKLVIARTEQVTNPAELLELMETSGATVLQATPGLWLNLIEHGWTGERPLKVLCGGEAMSRSLAEKLLDRSDDVWNMYGPTETTIWSSANRVTRGTGPMRVGPPIASTQFFVLDGNRQPVPSGVSGELYIGGSGLARGYWNRAELTAEKFIASPFGAGRIYATGDCARWHEDGTVQLEGRADFQVKVRGFRIELGEIEAVLNTHPLVRESVVVQHVTKTETADLARLVAYVAVKVDEQEDAAPALIEELEGLLMRTLPEYMVPNAVHVLEEMPRTPNGKVDRKALPDVFSQAGDSGIAQSANEAQSFVEAEDAVEKQIADIWQTTLGIPRISVKANFFSLGVGSLAALRLIRKMNKVYGTDLGLASLISASSIEAIAELIRNRFSPNTASSLVPIQPVGTRPPLFIVHGVGGNVVNFYGLSMRMGSDQPVYGIQSQALVANAPALLHLTDMATHYVKEIRAVQPHGPYHLLGYSFGGTVVLEMAQQLRAAGEEVAMVGMLDSKSKEYEEQFARSITVHSKVNNRVERFFRNIKDLSLDAKIKYVSDKISTRAIRFSAMAATRANVSHVPSFMKSAYDINYVAVQNYEPQPYDGKLILFRASEQDNRAGARDLGWGSIFRQGVEIHDLPGDHERIFMDPNIDELASSLRASLEACMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X024</accession>
    <name>E8X024_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oleoyl-(Acyl-carrier-protein) hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1874"/>
    <dbReference type="EnsemblBacteria" id="ADW68920">
        <property type="protein sequence ID" value="ADW68920"/>
        <property type="gene ID" value="AciX9_1874"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1874"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_1_0"/>
    <dbReference type="OMA" id="ALCRLIC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016295">
        <property type="term" value="F:myristoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004320">
        <property type="term" value="F:oleoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016296">
        <property type="term" value="F:palmitoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="230" mass="25341" checksum="819CF6DF3903352E" modified="2011-04-05" version="1">MRLFCLPHAGSGAAAFYRWKRLLPAGVSVCPVMLPGREIRIAEGALLRVSEIVDALHEAVKGSLDRPFAIFGHSMGALLAFEWAQRIAGDGLRGPACLFVSGRNAPHLPFRHRGLHKLADAEFVAELNVRYGGVPEGFLEDADMREFFLPILRADLEVVETYEYQVMEKLGVPVQAFAGVDDRSVSEDGLARWSEITNGPFSVRRFPGDHFYHLGVGQAELLRVIAETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X098</accession>
    <name>E8X098_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3059</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3059"/>
    <dbReference type="EnsemblBacteria" id="ADW70079">
        <property type="protein sequence ID" value="ADW70079"/>
        <property type="gene ID" value="AciX9_3059"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3059"/>
    <dbReference type="HOGENOM" id="CLU_2553496_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="9662" checksum="B7DD0DF113D51ECC" modified="2011-04-05" version="1">MDEIIFHPIYSLARNRSSEPGFDLSLLPLSITENVTLEDISPFLSKDSFNTWKRFLGEPEFERLGRIRLRWCDGLIRYQSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H8</accession>
    <name>E8X0H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0773</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579168.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0773"/>
    <dbReference type="EnsemblBacteria" id="ADW67842">
        <property type="protein sequence ID" value="ADW67842"/>
        <property type="gene ID" value="AciX9_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0773"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645467_0_0_0"/>
    <dbReference type="OMA" id="GPVCMVE"/>
    <dbReference type="OrthoDB" id="521300at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="42299" checksum="08D6DE2CC8FB8578" modified="2011-04-05" version="1">MKFSKIGRIVSALVASASLGLGMTACGGGTIGYLWALGTYYNQISGFLIDDFTGNLTAIPQSPFSSGGTNPVTILVKPGGRFVYVINQGSNDTVAPTATANASQSVAGNISEYSVGGDGTLTFQQTFTSQGVHPMWATLDSTGNFLYVLDKYAPDATGNGSITAFTVAADTGRLALLPNAAIKNANGTPTAYFSVSASPIMTKVGSGGCLYTMNANSVYAYVQSSTTGQLTLATTGSQSIGNGSAVQLSSINTSGSAGFIYLTDSGQNQIYSFQAGGTACSLAQINGSQTANVATTLQPVNSIVSSNGHFLYVINQGSTGGTQSPTASSISAFTINSLGQIATLSDSSNPYSTGSGPVCLAQDPSNQYLYTSNNTDGTITGKIIDQNRGVLAPLQRGSTFPSTMKSTCLAISGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K3</accession>
    <name>E8X0K3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid A 3-O-deacylase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1908</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580273.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1908"/>
    <dbReference type="EnsemblBacteria" id="ADW68954">
        <property type="protein sequence ID" value="ADW68954"/>
        <property type="gene ID" value="AciX9_1908"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1908"/>
    <dbReference type="eggNOG" id="ENOG502Z9EP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141313_0_0_0"/>
    <dbReference type="OMA" id="TNHKYPA"/>
    <dbReference type="OrthoDB" id="1236181at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233568" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="25931" checksum="566881768435947E" modified="2011-04-05" version="1">MSLAKLLVTTLAALACVTASAQTTGQTNPLESASVHQPTDYGVLVQGGNGITDNRDGFHFLAAGVHAGKVLTNNFGPGLLHGNFEYAMELFPYWQSFTPKFSKVNCSQLPGTAVVSCSQPYTVGGTYTGVSVTPIIMRWNFVRHGRLQPWVQAAGGVLWTNHKYPAYGSTNPDLQVNGPNGDASVWNFTPQGGIGFHYFTRPNRSIDFSANGEHISSASLGDRNPGVNASVQFTVGYSWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M2</accession>
    <name>E8X0M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1927</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580292.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1927"/>
    <dbReference type="EnsemblBacteria" id="ADW68973">
        <property type="protein sequence ID" value="ADW68973"/>
        <property type="gene ID" value="AciX9_1927"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1927"/>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_2_0"/>
    <dbReference type="OMA" id="IECIALC"/>
    <dbReference type="OrthoDB" id="1772839at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="17487" checksum="488946503B7A0F88" modified="2011-04-05" version="1">MIVVADTSPINYLVQIRQEEILERLFEQVYLPSVVYGELQDPLAPERVRLWSGHLPAWIAVVSPTIVPPDAALSLDPGETEAITLALELRSNFLPIDELKGRAVALLLGLKLNGTLGVLRDAHNHGWLNGRAVSAELRQTKFRCSEHMEQIYLASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S7</accession>
    <name>E8X0S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3091</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581425.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3091"/>
    <dbReference type="EnsemblBacteria" id="ADW70111">
        <property type="protein sequence ID" value="ADW70111"/>
        <property type="gene ID" value="AciX9_3091"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3091"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107963_0_0_0"/>
    <dbReference type="OMA" id="TLWTIPN"/>
    <dbReference type="OrthoDB" id="1533499at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234243" evidence="2">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="190" mass="20846" checksum="ED6BC5A01266CFB2" modified="2011-04-05" version="1">MSLRTILSSAALLTTLALAPAGFAQDGQMAGMQMAPESGKTMPSPPQTATVTLAGQTLTIKYNSPHMRNRQIFGGLVPYDQVWRTGANPATTLITPVALHIGSLLVPAGTYTIYTLPSRKKWMLIVNKQNGQWGTEYKQEMDLGRVELKEKSIAEPQEVMSISFDDIKRDSAELHIRWATTDESVKITTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U6</accession>
    <name>E8X0U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FRG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3114</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3114"/>
    <dbReference type="EnsemblBacteria" id="ADW70130">
        <property type="protein sequence ID" value="ADW70130"/>
        <property type="gene ID" value="AciX9_3114"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3114"/>
    <dbReference type="HOGENOM" id="CLU_569576_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014966">
        <property type="entry name" value="FRG-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08867">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00901">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FRG" evidence="1">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="54452" checksum="E41D88A3D0F32B17" modified="2011-04-05" version="1">MAKSDLSNPSMEAGENAAETLAPMRNLLGHVSTLAELETLVEGFRKEHPEEMLLFRGQTTCYPTVRSGLSRPKARYQPDVEQGLGAIIGGILGHDSVSIRNVPFRRAVLQHYSVQTHYIDLTSDMGVAAWFATSTLRPRRVIYAGAPLRTLDQSSYERRTEGLGYVLLFAIPNADELIANQRLFDISNLEPFLRPARQKAWLMSDRAPLLPDPNDFWAATITVDCGHFQSALSMQQLFPPPAEDKGYARLTDIPFVEIPDEWMRKEEEPRSEKKLKIDFGMRALPVPEYTARTDKDEFDHKWSDRTLSEAKPMQMWPAWNFELIDEISSISGNVANATKLTLSPRAQRILHDPGHNIPLRWPNLGTDELLFTFAQFGHDKVCDIEYPYHGVWLHRDKELVIEHPMTADEDVMNVHAGHVFEFIGQDLQRHDIGTSCKCGEPEGHEARVRAMLRLSALVEIEVLSMIPHPLNFSNWYFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z1</accession>
    <name>E8X0Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3164</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3164"/>
    <dbReference type="EnsemblBacteria" id="ADW70175">
        <property type="protein sequence ID" value="ADW70175"/>
        <property type="gene ID" value="AciX9_3164"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3164"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_29_4_0"/>
    <dbReference type="OMA" id="RTYIGMI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8253" checksum="AC7884FC3A3C8F0D" modified="2011-04-05" version="1">MPAHSPKFLFGKSIRTLREERGYSQEELAERAGLHRNYVGGIERGERNVGLENIVKLAKALSVKSRDLFESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z2</accession>
    <name>E8X0Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70176">
        <property type="protein sequence ID" value="ADW70176"/>
        <property type="gene ID" value="AciX9_3165"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3165"/>
    <dbReference type="HOGENOM" id="CLU_2935051_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6777" checksum="10DAFADF91E8C382" modified="2011-04-05" version="1">MKDYRVQPQPNSEETSLSTSVRLRVSETTQLVDLINTAFEGIPKWDAFAQHYGGCELCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X125</accession>
    <name>E8X125_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">AciX9_0823</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579216.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0823"/>
    <dbReference type="EnsemblBacteria" id="ADW67891">
        <property type="protein sequence ID" value="ADW67891"/>
        <property type="gene ID" value="AciX9_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0823"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_3_0"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="OrthoDB" id="1848013at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="29070" checksum="61AC483CD9ACD7B5" modified="2011-04-05" version="1">MADLIDNVRANVADRADLPGMTLMEHLDELRKRLIRAVIALLCGFGVAYIFHVRLFGYIQKPLNDLGMKLAFTHPTDPLNLYIKTALVGGAIIASPFILYQLWLFISPGMYANEKRYVWPFMGSTVGLFLAGAWFGYRYILPGALSTLINGFGKGFQPIITIEDYTGFFLAIILGLGITFELPILIFFLSLFGIVDAKFLLKHIRYAVLIIFLITAIICPLPDPISMCIFASPMLVLYGLGVVIAVFVNPNRRKAKELKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X129</accession>
    <name>E8X129_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579220.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0827"/>
    <dbReference type="EnsemblBacteria" id="ADW67895">
        <property type="protein sequence ID" value="ADW67895"/>
        <property type="gene ID" value="AciX9_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0827"/>
    <dbReference type="eggNOG" id="ENOG5032S87">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098310_0_0_0"/>
    <dbReference type="OMA" id="STWCAFA"/>
    <dbReference type="OrthoDB" id="1662398at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24530" checksum="19FD5586AEEFB926" modified="2011-04-05" version="1">MCFSATANFVGSGVLGTLGVATLPKVKHRRELLFAALPTLFAVHQFIEGFVWLGLDGYLSTAVVHNMGAAFVLYAQGLLPFLMPLSIQLFEPTIPRRRAMLPFTILGGLTTLYMLWALMAYPLQVYVERNSIVYVNQGTNYTTLAVLYIIATSGSLFFSKLKPMIWFGVANLIALLFTMAVKRYAFTSVWCAYAAVASIIILAYFWKTSKQRPYHYAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X188</accession>
    <name>E8X188_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1997"/>
    <dbReference type="EnsemblBacteria" id="ADW69042">
        <property type="protein sequence ID" value="ADW69042"/>
        <property type="gene ID" value="AciX9_1997"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1997"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_0"/>
    <dbReference type="OMA" id="PELCIRS"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="31882" checksum="AD339FA94EDF3B8B" modified="2011-04-05" version="1">MSLRRQFPKSLGFILSWMSGPELIEPKCSACKDGVSQPFPMTMAFQPIVDVLESRVYAYEALVRGLNNEPAGVVMAQLTEDNRYAFDQSCRVAAITLAARLGLKDTGAKLSINFMPGAVYNPAACIRLTLETARKLDFPLDLLIFEITEMEEIKDRNHVLKIAQEYRRHGFQMAIDDFGSGYSGLNLLADLTPDILKLDMDLTRNLHARPTALAIVRSTAELCRELGVTCIAEGVETVEELRALRSCGIRLMQGYLLARPAFEALPAVAYPQDLGALPGRREAAQSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D7</accession>
    <name>E8X1D7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2046</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580408.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2046"/>
    <dbReference type="EnsemblBacteria" id="ADW69091">
        <property type="protein sequence ID" value="ADW69091"/>
        <property type="gene ID" value="AciX9_2046"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2046"/>
    <dbReference type="eggNOG" id="COG3376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036094_2_0_0"/>
    <dbReference type="OMA" id="NGWVLYK"/>
    <dbReference type="OrthoDB" id="1515392at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37806" checksum="472E581B65634B61" modified="2011-04-05" version="1">MPTLLATAAPIRSKVITLYIALAAMNLGAWLWALIAFRHYPVLLGTAFLAYSFGLRHAVDADHIAAIDNVTRKLMQQGRRPILVGFLFSLGHSTIVVIGSILIAATTVSMQGHIAAFREIGGTIGTLVSTFFLFAIALANLAVLLSIYKAFRAVRRGEPYLDEDFDLLLNSRGLLARFFRPVFALITRDWHMYPLGILFGLGFDTATEIGLLGISATEASKGLSFWSILVFPTLFAAGMSLVDTTDNILMLGAYGWAYVKPIRKLYYNLTITSVSVVVAFAVGGIEALGLAAAHLHPSGLFWTLITRLNENFGTLGYAIIALFAASWLVSIAIYKYRRFDDLELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G4</accession>
    <name>E8X1G4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugal transfer protein TrbG/VirB9/CagX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581511.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3188"/>
    <dbReference type="EnsemblBacteria" id="ADW70199">
        <property type="protein sequence ID" value="ADW70199"/>
        <property type="gene ID" value="AciX9_3188"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3188"/>
    <dbReference type="eggNOG" id="COG3504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087514_0_0_0"/>
    <dbReference type="OMA" id="QYRSQYP"/>
    <dbReference type="OrthoDB" id="1175608at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010258">
        <property type="entry name" value="Conjugal_tfr_TrbG/VirB9/CagX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038161">
        <property type="entry name" value="VirB9/CagX/TrbG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03524">
        <property type="entry name" value="CagX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234076" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="277" mass="30515" checksum="64737440CBC66CBA" modified="2011-04-05" version="1">MKPPIPLLVSTGLLLATVPLRAATTPHPLLPNAPKTVTVSESQTPPVIRAGLLQSTLIVLPAEEKVANVFAGDTVDWVFDGGHVASRFVSVKPKVANGTTDVHVVSDHGNEYTLQLREVSNDDDPHFDSKVLIEPTDKPAKDKLVELPVFVPAAELDKAKQDAAAAKAAQLAELKAEETKSEQYRSQYPSSLHFDFAWDEKKGKELGLQQIWHDDKFTYLRGQFQETPALYEVKEGKPSLINFDFANGLYTVPKQLENGYLEIGKQKVEFHRNGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K7</accession>
    <name>E8X1K7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581554.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3231"/>
    <dbReference type="EnsemblBacteria" id="ADW70242">
        <property type="protein sequence ID" value="ADW70242"/>
        <property type="gene ID" value="AciX9_3231"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3231"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127639_0_0_0"/>
    <dbReference type="OMA" id="YGKFGWI"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14540" checksum="0E20DB3850FD468D" modified="2011-04-05" version="1">MARVTGIGGVFLKAKDPKTLAVWYAKHLNVALSDYGGITFRWSDEVPATSGATAWALFPETTKNFGSGPQTAMINYRVDDLDGLLAQMEKDGVVVDPKRENYGEFGKFGWITDPEGNRVELWQPVAKSEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M5</accession>
    <name>E8X1M5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system effector, Hcp1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0876</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579269.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0876"/>
    <dbReference type="EnsemblBacteria" id="ADW67944">
        <property type="protein sequence ID" value="ADW67944"/>
        <property type="gene ID" value="AciX9_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0876"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116190_1_0_0"/>
    <dbReference type="OMA" id="WEHTTAG"/>
    <dbReference type="OrthoDB" id="1153621at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03344">
        <property type="entry name" value="VI_effect_Hcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18644" checksum="A72CC48C3F1EB71E" modified="2011-04-05" version="1">MALNAYLTLKGQKQGQIIGSVTQKGRENSILVHAYSNQIVSPRDPASGLPTGERMHQPLSIVKEIDKSSPLLWNAFNTNENLTQWTLQFWSPALATTPLLPERQIYTITLTNASIASIHESMLDNEDPTRANYTLREEITFTYQKIQWLWTDGGITASDDWEAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N9</accession>
    <name>E8X1N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0890</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579282.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0890"/>
    <dbReference type="EnsemblBacteria" id="ADW67958">
        <property type="protein sequence ID" value="ADW67958"/>
        <property type="gene ID" value="AciX9_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0890"/>
    <dbReference type="eggNOG" id="ENOG5032SDF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551945_0_0_0"/>
    <dbReference type="OMA" id="RFINRRE"/>
    <dbReference type="OrthoDB" id="1722339at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="19393" checksum="4FC4755362A3BE94" modified="2011-04-05" version="1">MATRSYTSRRELEEYHFSPFVTVLAPLVLIFLQAYLPKVFPRLLILDLPLIAVIFFSVSRRSPIAGSLTGAAIGLFQDLLTHQPIGVNGMAKTVIGYAASSIGVQVDVENLTTRILMNFAFSLLQSVLLFLINRNLLGVHGYKTQWVHELIRAGINTGVAIPLFLVLDRFKQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V0</accession>
    <name>E8X1V0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2066</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580428.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2066"/>
    <dbReference type="EnsemblBacteria" id="ADW69111">
        <property type="protein sequence ID" value="ADW69111"/>
        <property type="gene ID" value="AciX9_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2066"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_0"/>
    <dbReference type="OMA" id="TCLGLDW"/>
    <dbReference type="OrthoDB" id="1547060at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="47022" checksum="F5F3BCD36B5AC670" modified="2011-04-05" version="1">MRIAYLDCFAGISGDMFLGALIGTGVPLEVLQDAATAMNLNVTLKQETVDRSGISSIKIHVLEGDKPAEGQAPDTFTHQAAPHVHTHAPKTQHQHKTGHPHTHEEPHTHDHPHVHGRSLSVIRTMIQAAPLAPAVKTLAIQTFELLGQSEAKIHNVPVDDIHFHEVGAVDAIIDIVAASAGIVHLNIGTWHASPVNVGGGMVVCAHGTFPVPAPATADLLRNIPTYSAHIQKELVTPTGAAILRALSPTFGPQPPMSIASIGYGAGTRNPESFPNVLRLSIGESGAPGPDSRTWVSTETTQEIRVIETNIDDATPQLLAHVADLALKQGALDVTLTPVIMKKGRPGTIVTVLCTPADQSTLTQLLLTELPTLGVRTRTETRTILDRTHRTAETPYGPIRIKSGSLSGTLLNETPEYEDCRAAAAAHKVPLKTVQQAALAAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z8</accession>
    <name>E8X1Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2115"/>
    <dbReference type="EnsemblBacteria" id="ADW69159">
        <property type="protein sequence ID" value="ADW69159"/>
        <property type="gene ID" value="AciX9_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2115"/>
    <dbReference type="eggNOG" id="ENOG5032GNW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201011_0_0_0"/>
    <dbReference type="OMA" id="MFKIAIV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="56" mass="6038" checksum="BBDD91177548E0EE" modified="2011-04-05" version="1">MSFGLYAFGYLIVIAGVAYMAHLMHLPQHWIGAIVVVLLGIGIVTGVQNTRAKDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X218</accession>
    <name>E8X218_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3250</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3250"/>
    <dbReference type="EnsemblBacteria" id="ADW70261">
        <property type="protein sequence ID" value="ADW70261"/>
        <property type="gene ID" value="AciX9_3250"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3250"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_0_0_0"/>
    <dbReference type="OMA" id="IRMIFPQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="26065" checksum="E01F4140FF315281" modified="2011-04-05" version="1">MKEWGVTPILHMMMTAAENLPTQVTLAGLQESAYVRFSVLALSSIFFLVDPFAALPTFLAVTAGADPQRRRRMAWKASVTAWLVLSLFALVGHLLFKLFGITLPAFEIAGGIILLLIGLDMLEAKRSPTQETGGDTEAAAAKEDAGIVPLGIPMLAGPGSITSVMVLVGQTQGHWGMIAVILAAIFTTAVICYLVLGNSDRVARTLGDTGIRILVRVMGLLLVALAVQYFVNGLVDLGVIAKYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X223</accession>
    <name>E8X223_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3255</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3255"/>
    <dbReference type="EnsemblBacteria" id="ADW70266">
        <property type="protein sequence ID" value="ADW70266"/>
        <property type="gene ID" value="AciX9_3255"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3255"/>
    <dbReference type="eggNOG" id="ENOG502Z80Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231052_0_0_0"/>
    <dbReference type="OMA" id="MIAIMID"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="570"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2215" mass="216001" checksum="7AA46A303456B31E" modified="2011-04-05" version="1">MKRTCPCLKRTCTWLLVILSLLVWTQAGLGSGPRYVTGRPYFLNEGRPIPWAQSNVLYYTDPGGLSAAVNHQAADALVASAAGVWSNVAVANIALSNGGSLAEHVSSGNAYLGPGGMVFPADVQSTNYGSVPIAVIYDTDGSVTDMLLGAGASSPSSCRQNGVTESVDRFDPVGYIQHAIIVLNGRCTGAAPQLQLQMQYQLERVFGRVLGVAWSQTNDNVLMGAPTPTYNQALNWPIMHPIDIICGAYTYQCLPNPFTLRPDDIASLVLLYPVTGTPGTGKQASYQTAQGVAGTISFPTGQGMAGVNMLVRRKSPQGVQEGWYEGSGVSGGMFKTNNLSPFVAADPSVQGSQGTSDQGALGNYSVAYIPVQTGAIWQDLVISTEAVNPLYFGPYSLQPFAAGSVSPSGSVAIQTAAFAYEGGTALESFTIGDAAAQCGTGMDGTAFAPVPVAATGWWNGLLCGQGHAAYGSLAVQPGRTLTVEVTALDEQGYATTVKAMPVIGVFAPGDGAGALPSVASAPSAFQARGLGTTTLLASTGALTQVRVGIADQRGAGRPDFGYQARVFYADSLSPATVPDAGGTVTISGTGFRQGNQVTVNGVAVPVVSAGANAIAVSVPAMAAVNATGGTGVDVVVADLSTGAVSTMTGALVYQAIAPNQMKLVTAQAGSVYDGDATSVPFAVQVVAGDGVTPVAGQTVVFGTSAGTVRYGACGGSSCSVATDANGLASTAVTPQSAGAVTMTATAAQTTGAALVQSAGFTAVAQDAALNVVSTPGASVTVGSASQMPFAVQAVNGGGGWSGNRPITFSVTGGAATLSGCNAAQCVVTADNTGTARINVTATATGTITLQAKDGDLTQSVSLQAVNVSDVMKLGSGPTGTNPLNQWGVRLSAQLLQGDGVTPDPFEQVIYSAPAGLLFQVCGGSVCALTTDLGGYVGTSMMATQAGTYGITIAYGAVKQTYTVTFAVPAPTMRLVRVPLGAQRVGSATNVPFSVQMLQADGVTPMTGTYVAFAGPSEAGTIAECDRDRPACSLVTDSNGITGASFIPNRPGPITISATFGTLTQSATFSVVGTTDVMSVIASPGAGTLTGDAEAFVVQVLGSNGVTPAAGRTVTFSVTNGSFVFSGCGSAVCSVVTDGSGKAGVSGVATAAGSVSVMAADGVVTQTMTFSTTMRPDVMRVVSGPAGSMMSSYAASPVFAVQVLGPDGVTPAVGRTVTFAVTGGSVSFGLCNGAPCTAVTDAMGMASTTVTALSAGATSVLAADGAVYVSDAFTAVLPDVVKVVSAPASGGYVGDVAATPFVVQVLGGDGVTPAAGKSVTFSVTNGSAGFGRCGNAVSCTLVTDGNGMVSSAVTPLGVGNVTLSAADGPVNATASFGAVAKPDVLRIVTAPANGAFVGDVAGVPLGVQVMLEDGVTAAVGKQITLAVVSGAAQLSACGVVPCVLVTDGNGMVSTGVTPLGAGTITLSAAEGAIVQSASFTAVTKPDVMVLVGGPADGSIVGSVAAASFSVRQMLADGVTPHAGQAVTFVGVGATLTACGGSTCTVMTDASGVAQTGVTPGVVGMVRLTATDGSLQQAYGFVAAPRPDVVKVLSVPGAGSPVGDPAAVVFGVQVLAGDGSGGMAGKTVVLSVTQGVAMLTACGAATCSLVTDGSGMVSTGVIPSAVGLVGLLAADGAVTQGASFVAGAQQPHVLKVLSVPADGAVAGNAAGTFGVQLLLSDGVRVVAGASVTLTTANGKLSVCGAASCVLDTDAAGMVSSGVTPASAGAVVLSAVSGGVTQTASFMAVRAPDSVTVVSAPSGQGYVGDAMAAAFGVKLTLGDGVTADKGQIVTFTVTSGSAVLGACGAATCAVTSDAGGVASTTVTPNAVGMMTVTATASAVAEGMVQASFKAVPKPDLMVVMGAPAANVYVGATTVSPLAVRVLLADGKTPVVGVGVTFSASGAGQAQFAACGAAVCSLVTDAGGMASSALVGVAPGAVTLTAAADASTGAQPVSAGLVVVANVYKLAATTPSLFVAQGTSFAANVGALATINGDAAGGIGVTWTGNGATLPGGMSGVTDGAGMVQAQVVFGPLGVGVTGTAKVCAWGTQCVSFGAVGVASSGLVLNVMSGGAQAVSGGAGFVPVVMQVTDLAGNAVAGAAVTISQTVSAMTVACPVHGRCPAAPVLASSAKTLVSSASGMVSVMPMTVAGTATETKLVMTVGTQAEATADAKSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X266</accession>
    <name>E8X266_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3298</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581621.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3298"/>
    <dbReference type="EnsemblBacteria" id="ADW70309">
        <property type="protein sequence ID" value="ADW70309"/>
        <property type="gene ID" value="AciX9_3298"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3298"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_0_0"/>
    <dbReference type="OMA" id="HARGEQP"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230177" evidence="1">
        <location>
            <begin position="24"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="402"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="668" mass="74275" checksum="5B64A59080CA73DD" modified="2011-04-05" version="1">MTHLSRAALAALSLSLCTTFAFAQDKPVGNDIPPSFTPPTRAPYKPFVEEADYTRRIAMIPMRDGTKLYTVIMIPKGAKNAPIVLTRTCYNAAARASANRETAGNALATAMPAARPGREAAAKAPSPHLIDELGLPDEVFVKAGYIRIYQDVRGKYGSEGVYLMTPPPVGPYNPTGADDTTDAYDTIDWLVKNTPESNGRVGMIGSSYEGYTVVMALLNPHPALKAAIPESPMVDGWKGDDWFHYGAFRERMLDYFVGQTAARGAGPRVPHKHHDDYANFLEAGSAGDFARSLGEDQLPYWKTVEAHPAYDGFWQSQALDKLVSAKPLTVPTMWLQGLWDQEDMWGANHAYKLWEAKDTHNDMNFLVMGPWFHSQINREGHTMGPFIWDGDTTEYVREDIFMPFFNQYLVDGAPKANTPPVLIYNTGENHWDKLQKWPLSCDKNCGATSKPLYLRAEGKLSYDAPTAGEAKFSEYVSEPANPVPFLPRTGDTGTWQTWLVQDQRFVDNRPDVLTYTSEVLTAPTRVSGVPEVNLYASTSGTDSDWIVKLIDVYPDDATGPAAMAGYELPISLDIFRGRYRKSFEHPEAAKPNAPELIKYDLPNVNHIFQPGHRIMVQVQSTLFPLYDRNPQTFVPNIFDAKAGDYKKATQHIYQTPGTASFINLPIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X270</accession>
    <name>E8X270_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3302</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581625.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3302"/>
    <dbReference type="EnsemblBacteria" id="ADW70313">
        <property type="protein sequence ID" value="ADW70313"/>
        <property type="gene ID" value="AciX9_3302"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3302"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509731_0_0_0"/>
    <dbReference type="OMA" id="TIICTMI"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="370"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="531" mass="57216" checksum="808E158C286FCE8C" modified="2011-04-05" version="1">MTKGLREDIEIVAAASGENPGAGPDSGVASRFTKNSLISVGRLFVSTAVALILPSYLTHKLPIKTYSAWILVMQMSAYVGYLDFGVQTGISKYVAEYEARNDAAGASMRASAGLAIMLVASALGVLLTLVLAWRVPDIFHEMPSSLYKDVRISLVLVGVSLSLGLLCSICSAIFMGLQRFSVPMAISLVNRFLFTGAVFAAVFFHSSLALMGGAVAGVNLLTGGLQVIAWRRMANNIRLTLRGLDRDVLKNMIAYCSSLAIWTAGMLCVSGLDVTIVGRYDFSHTAFYSIATLPTNFMLSIMGAAVGPLMPTASALSVHRTAQEMGAMLSKVTRYSSTLLVLAGLPLLVAGYWVLRLWVGSEYALHTIGYLRILVLANVIRNLCLPYSSMLVATEKQKVAIIGASAEAIVNLGCSLYLVKHIGALGVAYGTLLGSLVSVGMHFALSMRYTYERFSVTRMRLFLSGMIRPLAIGLPSLVLFKQWWVDAPPVLSLPMWALWGTSTLLLAWFASLNGDERSRLSKLVVKRAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X271</accession>
    <name>E8X271_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3303"/>
    <dbReference type="EnsemblBacteria" id="ADW70314">
        <property type="protein sequence ID" value="ADW70314"/>
        <property type="gene ID" value="AciX9_3303"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3303"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_2_0_0"/>
    <dbReference type="OMA" id="SEYVCFC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="37240" checksum="5FA8E0D044774342" modified="2011-04-05" version="1">MNSSSSPQVQILLATYNGARFLREQIDSILTQTYPCLTILSRDDGSTDGTLAILNDYAALHPTRFHILPQSPPTGSAKLNFAALIAASTASHVSCADQDDVWVSTKIADSMEVMQRLEQRHRHGTPLLVFTDVAVVDEQLRPLQPSLWRYQHIQPNKIFNFRRLLTQNVVTGSTALFNRPLADLAARMTAKAYMHDWWLALLASAFGSADFLTQQTVLYRQHASNVLGAAGHGSHSGLPKWRQHAKRREQWENSEHQASAMLEAYRDELPQKIRRMLEAYVRCETSPNRFVRVLTLISHGFLLQDLRPNLAILLYLWDMDFAKNHTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H3</accession>
    <name>E8X2H3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnogalacturonan acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2153</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580513.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2153"/>
    <dbReference type="EnsemblBacteria" id="ADW69197">
        <property type="protein sequence ID" value="ADW69197"/>
        <property type="gene ID" value="AciX9_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2153"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287319_0_0_0"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234298" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="22475" checksum="6998CAC87348492A" modified="2011-04-05" version="1">MMLGVMVPWIRRAAPVMIALASLSVANGQASAPNPNRPSLFLVGDLSSSSVGDTFDPNRIKLVESGAVGQTSRAYIKSGAWDQLAGQIKPGDFVLIEFNPEGQGGQDHDDAQRTLKGMGDGTFDYLDPGTKKLELVHSYGWYLRKIVVDAINHGANPILCSPLAGAKDGAGDWTKAIATEQRIPFVDLSGTGVKGGLVALKADPLAAYLVGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L2</accession>
    <name>E8X2L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2192</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580552.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2192"/>
    <dbReference type="EnsemblBacteria" id="ADW69236">
        <property type="protein sequence ID" value="ADW69236"/>
        <property type="gene ID" value="AciX9_2192"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2192"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_3_0"/>
    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="267" mass="27572" checksum="6E2B4EE6FA47C5C1" modified="2011-04-05" version="1">MKTGLTIAGFDPSSGAGVTADLAVMGALGVFGTSCITALTVQSTLGVRATHPVPPEVVASTLDCLAVDLPAAGIKIGMLATAATVEVVLEFLRGIGEGVPVVLDPVMRSSSGRALLDAPGVEAMRERLLPLVDWVTPNLGELEVLVGRELDTKEEMEVAALELGERWPGLNVVATGGDLDVPDDLVVTADGAAVWVPGVWIESTATHGTGCAFSTALMCGLVSGLEAVEAVRNAKQFVAGAIRRAEVRGGGKGPMELLWPLRTQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N7</accession>
    <name>E8X2N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3325</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581646.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70334">
        <property type="protein sequence ID" value="ADW70334"/>
        <property type="gene ID" value="AciX9_3325"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3325"/>
    <dbReference type="HOGENOM" id="CLU_2436671_0_0_0"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="10279" checksum="9BD81716C269A1A8" modified="2011-04-05" version="1">MALIKLRVERENGVQVGILAFDGELERKLTDIDQLIFEIRRAGIAPAEFVEEIADLEAGMPAAMIVKAWQHTAFFMPQERMFDFRAARDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P7</accession>
    <name>E8X2P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3336</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581656.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70344">
        <property type="protein sequence ID" value="ADW70344"/>
        <property type="gene ID" value="AciX9_3336"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3336"/>
    <dbReference type="HOGENOM" id="CLU_2522892_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9534" checksum="9C071079E7143A1B" modified="2011-04-05" version="1">MARVFDIEVTLEKAVTQQRLDMLIQSLSAKRVTFVPESRTTPRGSHDLRFAVYADFGQFMAGVVVRECVKTILGIDYALINERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T1</accession>
    <name>E8X2T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3370</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3370"/>
    <dbReference type="EnsemblBacteria" id="ADW70378">
        <property type="protein sequence ID" value="ADW70378"/>
        <property type="gene ID" value="AciX9_3370"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3370"/>
    <dbReference type="eggNOG" id="ENOG5031FT7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324811_0_0_0"/>
    <dbReference type="OMA" id="FVLGYHG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21537" checksum="4EEF563CF78E98B0" modified="2011-04-05" version="1">MHNLSASFILAYHGCDEAVAESLLHNRPFRASQNDYDWLGEGIYFWEANPLRGLEFALEASRRKPTSIGKPTVIGAVIDLGFCLDLTTSLGLRIAQTAFSRLEQVSREAGLPLPVNQPDGLRHNLDCAVLNYVHRLQAEEGKSPFDTLKGVFIEKPTLYPGSAFGIKNHIQIAVRNPECIKGVFRVPDAHLNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X317</accession>
    <name>E8X317_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ordered locus">AciX9_1088</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579474.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1088"/>
    <dbReference type="EnsemblBacteria" id="ADW68151">
        <property type="protein sequence ID" value="ADW68151"/>
        <property type="gene ID" value="AciX9_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1088"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_0"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26027" checksum="40F28DA07607AB34" modified="2011-04-05" version="1">MQVFVILPAAGIGTRMSSGGDKPAAAKQFVTIAGVPVLVHSLRAFLAVDSVAQILVAVRAPEVERVTELIHRFSLDAKVKVVEGGEHRQGSVANALATLDCAPDDIVLVHDAVRPLIEPATIERTIEAIAKYGAAIVGMPAVDTIKQVERTADGAIVSSTIPRERVVHAQTPQGARFHLLKKAFDEAEGDEFSGTDESSLLERSNVQVHVVPGSARNFKITQPGDLELAEFYLAHTDIKTGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X322</accession>
    <name>E8X322_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1093</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579479.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1093"/>
    <dbReference type="EnsemblBacteria" id="ADW68156">
        <property type="protein sequence ID" value="ADW68156"/>
        <property type="gene ID" value="AciX9_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1093"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_0"/>
    <dbReference type="OMA" id="YGRITYQ"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19857" checksum="4300E68E4F37F865" modified="2011-04-05" version="1">MAKLIYALNQSLDGYVDHLKLGPPGPIVFRHFVEHVSSLTGMIYGRRMYDIMRYWDEDLPDWNTTERDYAAAWRSKPKWVISRSLTSVGPNATLIADDIETAIRKLKTEQTGELEIGGPDLAQSLTQAGLIDEYQIYLRPVVLGSGKPFFTAPPPPLRLIASDPLGENIIRLTYVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X324</accession>
    <name>E8X324_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2204</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580564.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2204"/>
    <dbReference type="EnsemblBacteria" id="ADW69248">
        <property type="protein sequence ID" value="ADW69248"/>
        <property type="gene ID" value="AciX9_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2204"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2665959_0_0_0"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8599" checksum="81BA2A3CC26B3F8F" modified="2011-04-05" version="1">MEQHGWTSAEVVSSASHLPRTGLILERYKFGWRTHAAPNPVELSVGRNYFYYAREMAATAVLRWFGFAPTPFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X359</accession>
    <name>E8X359_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2242</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2242"/>
    <dbReference type="EnsemblBacteria" id="ADW69283">
        <property type="protein sequence ID" value="ADW69283"/>
        <property type="gene ID" value="AciX9_2242"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2242"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_0"/>
    <dbReference type="OMA" id="KESPWVP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="61"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="501" mass="54844" checksum="8C05E6B3C3E2CCAA" modified="2011-04-05" version="1">MMLGCLSVLGCHTRSDDAGTVVVLIESSPNSLDPRVGTDAQAEKIDGLIFDALVRKDERYEFKPWLATSWERPDATTWVFHLRDGVRFQDGRPLGAEDVAWTINSMVDGTLITAKGGNFASVQTARAKDRLTVEVKMKRADESLLFNLSDGLFGVVPKGSGREFGRVPVGSGAFRFVSAEQDKEVVLERVPSYWAGSRGNIERLRLSVVPDAVTSALELRKHSADVAVNVVTLDMVRALERVPGLKDETGPGSPVMYMNFNVTAAPLNDKRVRQAVAFAMDRKAIVDALWLGRARVADTLLPPGHWAAAAPGELTQYPHDPARAAALLEAAGYHADKDGVRLRLEMKTSTDETTRLLAEILQQQLRAAGIALTLRSSEFGTFYADVTRGAFQMYALRWIWSNEDPDIFHYAFATSQMPPVGGNRGRYSNARVDSLLAAAATTPDVSARRADYVEVQKILADELPAIPLWYPNNNIVHTDRVSGIVGDGSGSFDFLRDAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X366</accession>
    <name>E8X366_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69290">
        <property type="protein sequence ID" value="ADW69290"/>
        <property type="gene ID" value="AciX9_2252"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2252"/>
    <dbReference type="eggNOG" id="ENOG5032IGQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115879_1_0_0"/>
    <dbReference type="OMA" id="HVGNAGH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230193" evidence="2">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="15737" checksum="9E308C722CC36AD0" modified="2011-04-05" version="1">MSILKSLTVSALALGMLGASHVAPAQISIGIGEPSCPYGYYDYAPYNCSPYGYYGPDWFNGGVFIGAGRWYHGGRGFYGHVDNRYDPRHGYNGPYPDRGVQPFNHFQGNEARDGFGHVGNAGHDAGGEHGGGFVGHGGVPGGGGHGGGGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X368</accession>
    <name>E8X368_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2254</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580608.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2254"/>
    <dbReference type="EnsemblBacteria" id="ADW69292">
        <property type="protein sequence ID" value="ADW69292"/>
        <property type="gene ID" value="AciX9_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2254"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="DKICIMN"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="251" mass="27236" checksum="3A71E237B6039AAD" modified="2011-04-05" version="1">MPTPAIEFAEVSYAVQSRTLIDKVSLALEQGTTTALLGRSGSGKTTLLRMVNALVTPTAGEIRIAGVPNHLRNLTDLRRTIGYCIQETGLFPHMTVERNAALALEIAGPEPGQTKQTFRNRAAEVLALTGLDPALATRYPWQLSGGQRQRVGLARALAHDPEILLMDEPFGALDPITRAEIQTTLRALLQKLNKTVLLVTHDLDEALYLAHRVIFLEAGEVVADLNSAEVLTSPNAHVQTYVRAVHRGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E1</accession>
    <name>E8X3E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3437</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70442">
        <property type="protein sequence ID" value="ADW70442"/>
        <property type="gene ID" value="AciX9_3437"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3437"/>
    <dbReference type="HOGENOM" id="CLU_3118377_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="50" mass="5484" checksum="B4B4DC9D49DCCBC4" modified="2011-04-05" version="1">MGHRFVMVLGEDNEWVPAGSFGFVGRRETSPRTVQVALEPSWTAGYSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P9</accession>
    <name>E8X3P9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ordered locus">AciX9_2289</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580643.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2289"/>
    <dbReference type="EnsemblBacteria" id="ADW69327">
        <property type="protein sequence ID" value="ADW69327"/>
        <property type="gene ID" value="AciX9_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2289"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_1_0"/>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="OrthoDB" id="1632367at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="196" mass="22435" checksum="A1E69DF2FA9E372B" modified="2011-04-05" version="1">MSEQNQTLASASTQDLYREMIRRMGEDPDRDGLLRTPERMEKSTAFLTQGYKQTVTEVLHNALFDVDYDEMVIVKDIEFYSQCEHHLLPFFGKAHVAYVPNGKVIGLSKIARLVDVFARRLQVQERLTRQIAESIEEAIAPQGVGIILEAQHLCMMMRGVEKQHSHTVTSAMLGVFKTQLQTRNEFLSLVRHKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R8</accession>
    <name>E8X3R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2309</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580662.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2309"/>
    <dbReference type="EnsemblBacteria" id="ADW69346">
        <property type="protein sequence ID" value="ADW69346"/>
        <property type="gene ID" value="AciX9_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2309"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_0"/>
    <dbReference type="OMA" id="FLRTYMY"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="34057" checksum="9A0784BB4FFF1395" modified="2011-04-05" version="1">MDFDQLKTFLEVSKQKSFSKAAVKLLVTQPSISAQISSLEKVIGVRLFERGGGKVTLTAAGRVFEPFAEDCITRLNHISMTIADLERSPRGSLLISANDSTALYVLPTFFAAFKKRYPRVSLNIMRAERSKTIESVLNREADFGVVSLPVTDQRLHVELIHEDRWVLVVPPEHPLVGCTNVTLKQVAQHSLLVPKQGQRREHLDQLFTQKKLSPKIGMELDSYELLKRLIIAGMGIGFLPRINVLSESRAGLVHIVPSEEIVIPRNLAIISRHDRSLTRAGQAFYTVTTRLVHPSAITERTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W9</accession>
    <name>E8X3W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3472</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3472"/>
    <dbReference type="EnsemblBacteria" id="ADW70477">
        <property type="protein sequence ID" value="ADW70477"/>
        <property type="gene ID" value="AciX9_3472"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3472"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_7_0"/>
    <dbReference type="OMA" id="PHWVWVL"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="537" mass="57951" checksum="9E5C9D1532366CFF" modified="2011-04-05" version="1">MPHRSCFPHVFRTGASQLGRQIFATKSIDKLISESERPENALKKTLGPVSLTALGIGAVIGSGIFTVIGTAIGGNPAALKDWKGSPILDLVVGWLHHTSGAVAGRPGAGPALALSLVLVAVVCGLTGLCYAELASMIPIAGSAYTYTYATMGELIAWIIGWDLILEYAFSNMSVSVGFAAHLVDLLDWLGIHLDPKWLSPAYLPLGLQDLAGKDIFTTGWHFGFDFPAFFVVLLLTVVLVRGIRESAQTNNIMVLVKIAAILLFVSFGASFIHPSNYHPFSPNGFTGVLAGGSIIFFTYIGFDSVSTASEECKNPRRDVPIGIIATLIVCTILYIGVAAVLTGMVPWQTVAGDGAPVVNALKRVSLLPGGHRLHFVRLFVLIGAIVGMVSSILVFQLGQARVWFAMSRDRLLPDIFSTLHPKFRTPAFATWVAGILVAIPSGLFDVGTFAEMSNIGTLFAFVLVSIGVIVLRYKDPGRRRGFRVPFGPLIPVLSTLFCLLLMAGLPAITWVRFFVWLAIGLVVYFFYSRKRSEFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Y1</accession>
    <name>E8X3Y1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581800.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70489">
        <property type="protein sequence ID" value="ADW70489"/>
        <property type="gene ID" value="AciX9_3484"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3484"/>
    <dbReference type="eggNOG" id="ENOG5032UJU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537946_0_0_0"/>
    <dbReference type="OMA" id="IDGHIAN"/>
    <dbReference type="OrthoDB" id="1844444at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013417">
        <property type="entry name" value="CHP02588"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09624">
        <property type="entry name" value="DUF2393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18719" checksum="255772EFB32FEBB4" modified="2011-04-05" version="1">MSDQTPTPALFTPPTPERTSSPILPIAIAGLVVVLILAGILLATHRKPALNPNAIHPLDPYAASLPITGIVMSESTSLSGGKSTFIDGHIRNTGNRTISSATVQVLFANDAQLPPQLETLPLAVIRTHEPYVDTQPLSDAPLKPGDDREFRLIFENINSNWNQQLPEIHVIAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X451</accession>
    <name>E8X451_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">AciX9_0020</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578440.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0020"/>
    <dbReference type="EnsemblBacteria" id="ADW67111">
        <property type="protein sequence ID" value="ADW67111"/>
        <property type="gene ID" value="AciX9_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0020"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_0"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="6"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="370"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW67111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="52632" checksum="24984B634151A2E8" modified="2011-04-05" version="1">MSDTIFDLVVVGGGPAGYTCGIRAAQLGLKVALIEKTDKLGGTCLHWGCIPTKSLLFSAEIWDHLKHAANYGIDNVDAPKLNWDNLIKRKSDITNKHTKGLDFLMKKNKITVFRGHGRLTGPAKDGIHTITVTDEDKASGRGKDAQAEGYTSQKVDEIKAKKVVLSTGSDARMLPGYKADDTILTNMEILTLPAMPKSMVVIGSGAVGVEFASIFKSFGAEVTIIEALPRLVNAEDEEISKELLRLYKKRGFEVFLSAKVEKIDKKDGGAVVTFTDSTGKQQTKTAEKVLVAVGRAPRTYDCGLDKVNIPLDRGFIMTNEWMETTEPGIYAIGDIVGGLPQLAHVGAMCGVVVASKLAGKYARPVNRQRIPGCTYCDPQIGSVGLTEAQAKEKGYQVKVGKFPFVGNSKATILDSHDGFVKVVSDAKYGEVLGVHIIGPQATEIIAECVTALELEATVEEMMFTIHAHPTLSESLLDGFSSVEGMAINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X467</accession>
    <name>E8X467_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0036</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578456.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0036"/>
    <dbReference type="EnsemblBacteria" id="ADW67127">
        <property type="protein sequence ID" value="ADW67127"/>
        <property type="gene ID" value="AciX9_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0036"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335957_0_0_0"/>
    <dbReference type="OMA" id="WECFALE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="175" mass="18514" checksum="788785D5A7FB4A6F" modified="2011-04-05" version="1">MSSLKMASVVLHVVVVAALLYKVQGVAKAHRAKSVARVLVPYAPGHTAAAQPPKPKIIRPKVEPKIALKEPEPPPPASGGDPTGEADVSVAMANFYPAPKPDLSELPHGTHGDIVVDVTIDEDGKVVYTHVDEGLGHGVDEAVLAVLQTWTFYPATKAGKPVASVQQLLFHFDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X478</accession>
    <name>E8X478_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0047</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0047"/>
    <dbReference type="EnsemblBacteria" id="ADW67138">
        <property type="protein sequence ID" value="ADW67138"/>
        <property type="gene ID" value="AciX9_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0047"/>
    <dbReference type="HOGENOM" id="CLU_1903752_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="15034" checksum="BFE007092377B011" modified="2011-04-05" version="1">MTAGSLTLFILLANKPYGIQEASVVEYTLFEIFLTFAATRSLRRYLFTCPAVRPQIPRLLWRHLGYVITLVIFQAVMLAARPNLSSWWNTPDKKGSTPFEIALFFLCFGIGYAQVLGSRSILERAHQDFSTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A3</accession>
    <name>E8X4A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0072</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578492.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0072"/>
    <dbReference type="EnsemblBacteria" id="ADW67163">
        <property type="protein sequence ID" value="ADW67163"/>
        <property type="gene ID" value="AciX9_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0072"/>
    <dbReference type="eggNOG" id="ENOG5033DPP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165355_0_0_0"/>
    <dbReference type="OMA" id="PHPSEKF"/>
    <dbReference type="OrthoDB" id="2082505at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="25547" checksum="437A925DA7EFD10F" modified="2011-04-05" version="1">MPINDGKINAGEHAPPKGDIVNHPDSGPESVKLGYETTDVNAGGVAVFLAGLFGFVLIFFAFCFLMGKTINTALEKQDGPVDKWHNQNTIFEGALANGGKREDLKSNAAIQQQQLQQMTAAFPGPRLQTDDGNQDTADLHAREDLLLDHYSTTAGEQGIRIPIDRAMLLVVQKGLPVTAAAQSGQELAGDHKPVVLVPLTSGFARTGYELDTIEARAQKMSFAKEEESSHAELKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B0</accession>
    <name>E8X4B0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M56, BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579560.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1174"/>
    <dbReference type="EnsemblBacteria" id="ADW68237">
        <property type="protein sequence ID" value="ADW68237"/>
        <property type="gene ID" value="AciX9_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1174"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="WPSIFTA"/>
    <dbReference type="OrthoDB" id="1303552at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234363" evidence="1">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30865" checksum="C92D1178E7849F06" modified="2011-04-05" version="1">MFLITRFRVCLLAALFVSLAGSCVYAQTPIVEEPGYTPTLTFDVATVRLAPPPDANFHVSVTSPPHSSRFEATNLPMKALIQIAYGFGAPVTGAPEWVANTFYVIQARSDEAADARLAKLTDNEVRLEKRHAIRELLAERLDFKTHLETRPSSIYNLVTAKSGVKMEAVPAPAARAEGEAAPPMAPANVQAHGSQHGLEFVGSNAPMAAICGALSSMVEAPVVDKTGLAGTFNYVLQFGRDWSVKDPESWPSIFTAVQEQMGLKLEAVHESVPNLVVDHISKPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D3</accession>
    <name>E8X4D3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tex-like protein protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1197</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579583.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1197"/>
    <dbReference type="EnsemblBacteria" id="ADW68260">
        <property type="protein sequence ID" value="ADW68260"/>
        <property type="gene ID" value="AciX9_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1197"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_0"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="3">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="645"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="765" mass="83795" checksum="B7B10C86FBDF354E" modified="2011-04-05" version="1">MSETKTLPHEILFHIAQNLSSPLSSVVAVISLLDEGGTVPFIARYRKEATGALDEVKIREIEEKLAYFRDLLSRRETVLSSIAEQGKLTDELKAKIEGTLDKGELEDLYLPYRPKRRTKATIAKEKGLEPLADYVWGQAAGALSLMDLAGSFIDEAKGVASIVEALEGARHIVAERIAETAELRKALRTLLHDEGVIVSRKAMDAVDAQEKFKMYYEYREPVKTIPSHRMLAIRRGEAENVLYFLIEMDAARATGIMRKQVLGPDGDWTAQLELAIEDSWSRLLSSSIQGELRLELKKRSDVDAIQVFRENLGNLLMGAPAGPIAVLGLDPGLRTGCKVAVVDETGKFLAHDVIYPHTGQTAKSNQVMAGLVKAHNVRAIAIGNGTASRETDAFVRDFLAEQGLTEIFKVMVSESGASVYSASDVARQEFPELDLTVRGAISIARRLQDPLSELVKVDPKAIGVGQYQHDVDQRQLQQSLEATIESCVNKVGVDLNTSSWTLLRYVAGITERTALNIVQFRDENGRFNSRAQLKKVPGVGAKTFEQAAGFLRIRGGVQPLDSTSVHPESYALVEQIAKEVGAPVDRIIATPGLLDGVDKSKLAGGSFTLNDILEELRKPGRDPRDKFVAPSFHEGVRELADVQPDMVLEGVVTNVTKFGAFVDIGVHQDGLVHISELSNRFLKDPNEAVKVGQIVKVKVISADMASKRIALSMKALMSGVVPAARAPQVRGQERGRPQMQPKVAAPKPQTMDDKLAALSTRWKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H2</accession>
    <name>E8X4H2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1236</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579622.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1236"/>
    <dbReference type="EnsemblBacteria" id="ADW68299">
        <property type="protein sequence ID" value="ADW68299"/>
        <property type="gene ID" value="AciX9_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1236"/>
    <dbReference type="eggNOG" id="ENOG502Z9HI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086377_0_0_0"/>
    <dbReference type="OMA" id="WASGINL"/>
    <dbReference type="OrthoDB" id="1828070at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="201" mass="20930" checksum="F545D43C421AF776" modified="2011-04-05" version="1">MGISAGDLAGLVIGVSFAAGLNVYATLLTLGGLSRMGWVQLPGGMEVVGSWWVIGISAGLFLVEFVADKIPAFDLVWNAAQTFVRVPVAGLLAYGATSHLRPEMQVLVTVLGAVVAALAHGSKLAVRGLVTPSPEPVSNIALSSMEDVGAIGLTWVAVHHPYVAAGVVGGLVLVAGVMVRSLVVWGRRMWERRRGDVVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I1</accession>
    <name>E8X4I1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal transduction histidine kinase, LytS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2354</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580707.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2354"/>
    <dbReference type="EnsemblBacteria" id="ADW69391">
        <property type="protein sequence ID" value="ADW69391"/>
        <property type="gene ID" value="AciX9_2354"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2354"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_0"/>
    <dbReference type="OMA" id="DLSIYRW"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="455" mass="50464" checksum="552A5181D5E1E682" modified="2011-04-05" version="1">MKPVSTSLILITLLVELGVAAAVSSSLARSKTFRNLLLTTHRTIRQTAQLVTIFSVPLILGVWIRVRVPNFLAADISFEATILLGVLVGPLAATVGGAALAVPALLHGEFWALPVNVAIAAVAGSYKRFAESEDVWSFSPLIDLSIYRWITRNLKRPHLDRQILLLMLITAMEFCTSELSRFYPQRFFELHSSSWLVELAICFCAPVVVGIPLKIWNQIRIERKLEEQSRLLLEARLDALQRQINPHFLFNTLNSITSLVRSQPELAREMIVKLANILRILLKDREAFVPFAEELAFTDDYLDIEVVRFGEKLRVVKEIAPDTLGVVVPSMLLQPLLENSIKHGLEPRIEGGTVTLRSRITDDGRLLVEVEDDGVGMAPERRVAGELRTSGTGIGMRNVKERMEVLYGTSAHVEIESRPGRGTKVSLLMPVLEGGAGGWEMVREAVGNALKGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I6</accession>
    <name>E8X4I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2359</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69396">
        <property type="protein sequence ID" value="ADW69396"/>
        <property type="gene ID" value="AciX9_2359"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2359"/>
    <dbReference type="eggNOG" id="ENOG5032FIQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1747069_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16933" checksum="78AC8F0D928091FE" modified="2011-04-05" version="1">MPYSVKTMTSPQDLANGLSAILPNVKCGALRFWGAWFGRPYDNGHRLVECHGSEDCLRLEFNEGEVLAVWNPSDVQITETSFRIGCATALRWTWFYYGRPKTPENLYYLDYAQQDGGIVFRTNWDTIPGNGWLEKDASSYPAVEMPDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M3</accession>
    <name>E8X4M3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2396</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2396"/>
    <dbReference type="EnsemblBacteria" id="ADW69433">
        <property type="protein sequence ID" value="ADW69433"/>
        <property type="gene ID" value="AciX9_2396"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2396"/>
    <dbReference type="HOGENOM" id="CLU_1701778_0_0_0"/>
    <dbReference type="OrthoDB" id="1513850at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="154" mass="16676" checksum="C52AFFCF8D0CB73E" modified="2011-04-05" version="1">MRVLDSSDAGSWRDRTIVDRGGLVLVLLGCGFGWQKYEFVHAAVKTDALVVGNTKFAAPDGSVAYRPIFQFTTPDGRKRTGEADAGSHTQGYVPGDRIRVVYLADDPYGAQMDSFQQLWLVPVSLGGIGALLLGLGWGIRALGVMRQYRWVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4M9</accession>
    <name>E8X4M9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase, E subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2402</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580755.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2402"/>
    <dbReference type="EnsemblBacteria" id="ADW69439">
        <property type="protein sequence ID" value="ADW69439"/>
        <property type="gene ID" value="AciX9_2402"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2402"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_0_0"/>
    <dbReference type="OMA" id="VGKFHVQ"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="18844" checksum="92457673D33DD710" modified="2011-04-05" version="1">MSAIANTIFSPEMAAKFDHLITIYPLKRSALVPMLLYAQDELGFVSEPAIKEIAQRLDLFDLDVRNVLSYYSMLRTKPAGKYNVQVCTNISCMLRGGYEILDHCKAKLGIGHKQTTPDGQFSLEEVECIGACCWAPAMQVNYDFHDDLTTVKVDDILAEYAAGRGKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X517</accession>
    <name>E8X517_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="6">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpD</name>
        <name evidence="10" type="ordered locus">AciX9_0132</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AhpD family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0132"/>
    <dbReference type="EnsemblBacteria" id="ADW67209">
        <property type="protein sequence ID" value="ADW67209"/>
        <property type="gene ID" value="AciX9_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0132"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905408_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="8">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SIP" evidence="9">
        <location>
            <begin position="228"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="33212" checksum="E869512DD5C63E9D" modified="2011-04-05" version="1">MSSMPCRPMNYAPATGKKAKRPSQPKRRLHHDVRRSYGSLSAFAKDLKLNDSTLIRNNTELTLQQLWGTVVASAIGTRNSVLTAAVLAEASKHLSDAAIEAAKAAAAIMGMNNIYYRFQHLSSNEEYARLPARLRMNVLRSHGVEPLDFELWSLAVSAINGCGKCVDSHEKVVRDKGAAEELIAAVDVTLHGNGVFSRWVASASPGASVESYLPCGVCKAPASGRCCIFAGDETAAPSILTILQSLPDGVKERSFIEVESEMDIPLCTRELETDICWLSRDAGRHPVGHLLTNAITSIPNLRSNDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A0</accession>
    <name>E8X5A0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579687.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1302"/>
    <dbReference type="EnsemblBacteria" id="ADW68364">
        <property type="protein sequence ID" value="ADW68364"/>
        <property type="gene ID" value="AciX9_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1302"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028735_0_0_0"/>
    <dbReference type="OMA" id="CFAFTHR"/>
    <dbReference type="OrthoDB" id="1452803at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="503" mass="55685" checksum="DCB9320BCCCF358A" modified="2011-04-05" version="1">MKSLRTLQILTVTALGMAALLALIPAAGHDQLWFLLMAQRWLHGATLYGPEIFDSNTPAVVWLSAIPVAMAERLHLGIPFAAKLLAVLLEAGIATLSWRILSLRVTLSPSQKAFLAFAFVTLFAIVPARDLGQRDQLAVLLCLPYVLAAASESSPPLALLAAIGACLKPQQALVLVAVEITVLIRRRRPRVDSAVILLAGAAFLLAVHHLTPLFFTLTLPTLLSTYWAIAHLTLFQLFLESLQLHVLALIALALFFRPRLQSAPATTLRPTITLFLVAGTAATLAYYLQATGWYYQQLPGIAFFGCALALELVVLTDAHPIPTPAWFPYATAALGVLALTLTIHFSGYPFSLRPFTEDRTYAIDTPDPTFFASLPPGTPIATLTTSVDDAIMPVYRYRLMWSQRTNNLWTLPAILRGTKLTPLRRAELIAQQHRWMVEDLTHWQPKLVLVARCQDPAVRCQELEDRHDNLLAFFQQDPAFNAIWSHYRFLRSSGPYDAYALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F8</accession>
    <name>E8X5F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2472</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580821.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69505">
        <property type="protein sequence ID" value="ADW69505"/>
        <property type="gene ID" value="AciX9_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2472"/>
    <dbReference type="eggNOG" id="ENOG5032SV3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309592_0_0_0"/>
    <dbReference type="OMA" id="MICKATF"/>
    <dbReference type="OrthoDB" id="2061515at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234404" evidence="2">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="24423" checksum="89FA950647A314A4" modified="2011-04-05" version="1">MPSLVPSRLLLALALPLAAAAQTPAPHPSTLPATPPTTPQPAPTPAYQPPAPPAASRATITWTAGQLSVVADNSSLNQILRDISRQTGLKITGGVQDERVYGTYGPAEPATVLATLLTGTGSNMLLRQPTGNAPQELVLTPRQGGPTPPSPASSHPDDADENAIVPPPRPQRPPMPFAPPPPTNIQSATQQQQNSGQQPPPDTSTSSDTGVRTPQQIYDQLMKLQQQKSTAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I9</accession>
    <name>E8X5I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581927.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3613"/>
    <dbReference type="EnsemblBacteria" id="ADW70616">
        <property type="protein sequence ID" value="ADW70616"/>
        <property type="gene ID" value="AciX9_3613"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3613"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_6_0"/>
    <dbReference type="OMA" id="GHLIHHP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="48919" checksum="68D9F59267D85489" modified="2011-04-05" version="1">MVMPRKFFRSKLRRLWARLFAPMAQHELYEELLYYTRRNLSLDQLLETVPNRISFALNLSGFHVFLREGSEYVLQHPATPRITFPASSSTVSRMKRERKPAIYVPQGSDRAPIDGWQHLATPNEINTLDLLNAQLLLSLEGSTGLMGFVILSRSPYKPFDSKELRFLLALGPQIGRGFETAQFVLSISRQEVQRAHLARELELAREVQERLLPDEIPIVAGIDAAAAYQSAERIGGDYYDLFLAPKGALCIVIADVSGKGLSAALLMASLRASLHSTMLQPDMDAVTAVQRLNTLLYQSSSASRYATLFFAIYDPHESTLTYVNAGHNPPILQRADRSLVRLECGGSVVGLLSGLTYEHEIIDWRRGDRLIAWTDGVTEACNIRGEEWGEAGLESCLLKQRDLTAQASVRDVLTALKSFTAGAAQNDDITLLVLNRLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q7</accession>
    <name>E8X5Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3995</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70791">
        <property type="protein sequence ID" value="ADW70791"/>
        <property type="gene ID" value="AciX9_3995"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3995"/>
    <dbReference type="HOGENOM" id="CLU_1649738_0_0_0"/>
    <dbReference type="OMA" id="MLHAQTY"/>
    <dbReference type="OrthoDB" id="474248at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="19589" checksum="840D369827FD9EDB" modified="2011-04-05" version="1">MSIPSIRSKYQVETLTQPQDQSSAETNFPTVGRWLVTALPRGWLYVANFGIRQMAVDAQSIVANVSLGQDELGEADDLAGYIAAQSKLIAHHLDDPTMAGPKPMEFPGAEEACLFFVRHVPENAGSMLHAQTYVRSGRWVGIITLTTRETELKAVRPDYDAFVKGLHITPEPAVNAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X699</accession>
    <name>E8X699_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4205</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70983">
        <property type="protein sequence ID" value="ADW70983"/>
        <property type="gene ID" value="AciX9_4205"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4205"/>
    <dbReference type="HOGENOM" id="CLU_009397_4_2_0"/>
    <dbReference type="OMA" id="FIYHTGA"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233732" evidence="4">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="358" mass="39548" checksum="5735F4AFC800CED5" modified="2011-04-05" version="1">MKKSFQAALILFVLMQFAGLAWGQAPTGLGEQGWYADPEAHVFAGEYWIYPTYSDPAPLPVGASQFTELQQARRDEKGLRKAYLQQTFMDAFSSPDLVHWIKHPHVLDVKNVPWAAYAVWAPSVIELKGKYYLFFGANDIQKDETTAGGIGVAVSDSPGGPFVDAIGKPLIGAFYNGAQPIDPFVYQDDDGRIYLYYGGQGHCNVVGLTADLKAVTPLPDGELYKEITPAEYVEGPFLIKRNGVYYFMWSEGDWGDSSYGVAYARSSSPIGPFTRVGKILQTDARVANGPGHHSVIHLPGTDEWYIVYHRHPLGNTEPNQRLMAIDRMYFDKDGKIVPVKMTAKGVAARRLGGDSQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B9</accession>
    <name>E8X6B9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4226</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572915.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71003">
        <property type="protein sequence ID" value="ADW71003"/>
        <property type="gene ID" value="AciX9_4226"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4226"/>
    <dbReference type="HOGENOM" id="CLU_361219_0_0_0"/>
    <dbReference type="OMA" id="ATRGREW"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="809" mass="87312" checksum="DA739BCC72F21208" modified="2011-04-05" version="1">MAAIVPGSGNSPSGTASEGAAEGPARGGRRILFGDFEAQPAAGLLLRNGHRVRIQDLPFRMLMVLLETPGEIVTREELRNRLWGEKTFVEFDNNLRVAAAKLREALQDSAAGPRYLETVARRGYRFLGAVETIAAAVPVPEAEVPEPPRVDVLPDIDATTQVPLDEGRGRRPFALLGLAAVLLVGLAVWMAWGWRHHRPILAEGDTVALGSIENETGDASLDDALSLAFRIKMEESPFLHAISGEHFERASAVLQSGKGAKLSRAAAELSVCGSSGGRALLNGRLLRSGSGYTVRLAAERCTDGREIASTEASTNSAETLLAALGDAANAIRLRLGEPTATLGRFDVPLTQATTSSLAALRAFREGEQKHFAGRDLEAREDFKLAIDLDPNFALAYLQMGRSYSNNGERSLSRAYYQKAFDLRDRTTDREKLYIATSYYGYATGELGRAISAYELWSSLYPHDVVPANNLATEYLSLGEGQKAVASVRRAIALEPALPVPYTTLAQALLISGDLPALSTLCNDRQREESTSMGFHMACHELAIVQGDQGRQQSEERFVHGTPLESLLLNDAAEAEVYGGHLRRAAEMFQGAIDAARAHAMPELASVIELNGAGIFAELGESATAVRWAEDEQAHSQPGADLDASAAMVWATLGNESRAREFAAAAKALSPTDTLLNESELPVAYAIVALHAGRPRDAVAVLAPARPYDLNNSMELMPIYYRARALLASGDRAGAAAEFERLLANAHQRPRSVYLPLSRLALVKLYAAGGQAERARAMKESLEEIWRTADPNFAPLHSLRGSVSDHDDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I9</accession>
    <name>E8X6I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4305</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71073">
        <property type="protein sequence ID" value="ADW71073"/>
        <property type="gene ID" value="AciX9_4305"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4305"/>
    <dbReference type="HOGENOM" id="CLU_257293_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234448" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1356" mass="144750" checksum="FD0163DB69E264EC" modified="2011-04-05" version="1">MKRLLKSAVFLLLFSASMAAFGQSLVDGRVVFGNNFKPVPQLTVHLVNKTRKPPVDETQLTAPDGRYSFDDVQPGKDYAVAVYDNTGKLVGTDASFEVLPDSRHTALPNIDISKGVLADREVKSGGLIQNDQGVVPGANISNQQLRVLPLYNRTFLALGAIQPGVHDVPQGSPLQGAAFSIAGSQQTSSNFLLDGVDNVASSNNQAIPFQINEAVQEFRVIYAAPDMRYGQGSGGVIDVVTSRGNAASGSKAWHGSLFDYFNNDSLNAGSPLSVYSTSTFAKAAATASDGAGDAVSVANHTIISDPSYLGYAPQRYDQLFNLVSPGSPIGGATSGCGTFLCQAGSFNPASILATQDSNTYPITSQQFGASAGGPLLSNNKLFLFLSYEGTRIDNPTPIFERVPTFLDNPIANVDGAIAKGVLGLLPGPNVGQTGTSLMTATGAGTFGFYRGFAPNYTHVHNLHVRPELSLGSLGTVSLRYTGQLIDQLHDDTLPAGEAYPGNGANRRAQNQSAAITYNLPFGQSLNTMNIGFTQFRVDDVAQDRNFSAASLGLAAGSLSTFAISGIDTRITGAAPAQPGLMGGWYDSFWNACPNGTASCTTASRNSPSAITPSLDGQFPLPRIGAPLGAPSKHRDSEAFFSDILDLHFGGHNNLTVGGDYRYQQNFSYDGGMARGLVVSNNIGEFTSDSETCISCGLGIAFQHPSFDYELRQPIGYTGDLRSSSFGVFAEHKFQPMPTLTFSLGARYEFFGEPMDTGNRLWNYVAADQGLVKQGSNGTYDAFQYQCGAENTTSLDSLYGNRRVTFGSGWNCTPNGSFSLPNNKNNVMGHFGASYSPDSKFHDVFRASGGLYYDHLPASYTQQLLQNRPSPYNVTNPSAIYGQNFDSAACGTSQTQCGFGLHTLNFQTLNASDSANFQSYQAASGANILYERDVTRLKTPYSIQFTASWQHTFGPSWAGEIAYVGSVNRDLPLIYDSNFSNEFYCTQGGGTSTSPGGLCNNNTFFPVFTESNVGSSSYHSLVLRMRSEQYHGLSMHAAFTYSRSLDDVAGSNFPRSTDALWSQIFGRQLFGAGNPTAFALGANSLSNPHVNGARFNSLAPTAAGQSSLAQALVQAANIPSFDAVSSALTTTGSRPVDISQYSLPQNPLGFSSRANGGDYGNSDFDVRNRAVADFVYAPNFHKKWTNGFVLSGIFTAQSGQPFSIFSGPAYGQVTQRINLPTNTQIHSTGKPTGYFTGVGASSLVSVGAAASCPSLYAQPTLYSNKSNPVACVGNSARNGFSGPIYISQDLALQKSIAFREHHSIILRVEGFNIFNRANYYNPISELSNDGVHINPEFGLIRSAHDPLSIQFAGRYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S9</accession>
    <name>E8X6S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3953</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582247.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71229">
        <property type="protein sequence ID" value="ADW71229"/>
        <property type="gene ID" value="AciX9_3953"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3953"/>
    <dbReference type="HOGENOM" id="CLU_037308_0_0_0"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="43955" checksum="521DFE1344FFB791" modified="2011-04-05" version="1">MRSDHNDVDELPVVVVGAGPYGLSIAAHLAEACIPFRIFGGAMQMWREHMPAAMTMKSDGFASNLSAGSDRSFTFRQFCKERGLPYVDRHFPMPLKDFVAYGLEFQKRFVPQLDPRHVTRVERHEKGFKVVVEDGEFVVACGVICATGVMHYPYLPEPLKVLHSKLVTHSSEHTEFSEFAGLSVAVIGAGSSAMHTAALLSEAGAEVTVVTRRSKIIFHDSPTGGRRSLVERVLHPTSKLGPGLRSFFAEHAPLSFHRLPVDLRLKIVQKHLGPSSAGHLRSRVEGKAKLLLQRQITSAKAVEQCVQLELEGPDGRETIDVRRVVAATGYHVDLKRLRFLEPLLKEIECNHKSPLLDHELQSSVPGLYFVGLPAAASFGPLLRFAAGSAFAARTITQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X706</accession>
    <name>E8X706_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3829</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71115">
        <property type="protein sequence ID" value="ADW71115"/>
        <property type="gene ID" value="AciX9_3829"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3829"/>
    <dbReference type="HOGENOM" id="CLU_397747_0_0_0"/>
    <dbReference type="OMA" id="DHEHAIN"/>
    <dbReference type="OrthoDB" id="1442278at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="660" mass="72497" checksum="4CB8C36FBC853BF5" modified="2011-04-05" version="1">MEGMSQVARFSIYSLDLVTLELRRKGQRCALQEQSARVLAVLLSPPGDLVTRERLREELWPDTAYFDYEHAINKAISQIRKALGDDSRSCRFIETVPRQGYRFCGDAHMDAAASVERTVEPISMKVLSGTEHSVPARLVVAEAVPVEGTEVSVGATSAWKRYAFLSVAICVLVLIGLFAARHIWRSRAAVSPESPLILGMLPFETESDAAKAIAENLRFDLSDSLGQVPGLQVRAAHSFTTAPRDNASMRSLASTAGLDVILLGRLEVNGTNCLLHFEVVRAKDNSHIADLSFVGNVNQLHSLRDRVQYAVYTTLGGKPGTLQHIQQRTANPEAYEAYLDGRHYLQARTDDSLNHAMDRFQHAAALDPKFASAYAGMANVYLIFADRGEIPNGFDMAQRLANKALSIDQSSAQAHAILGCTAQSRGWDSVTAERELRLAVDLDSGEAVYHIWLATLLSIQGKADESLQQIALAESDDPFWPPVYQAAAFVAANAGKNQLMLADAGKMVELTPRWPIAADQLAWAFWYSHRYSDAIAEWQRMAQLSNDADRLALEAAGEQAFSKGGATAYAKVRLAALNTKSGHNYHDKTIEQAEWNVYAEQPGRALEILSAMVQEHDPAAITMAVDPAFVSLHTDGRFLDLLQRVGLPNVVPIESKRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X728</accession>
    <name>E8X728_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582158.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71137">
        <property type="protein sequence ID" value="ADW71137"/>
        <property type="gene ID" value="AciX9_3852"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3852"/>
    <dbReference type="HOGENOM" id="CLU_041517_0_2_0"/>
    <dbReference type="OMA" id="HELNIQT"/>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="123"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="46054" checksum="FE30BEA4D2397D56" modified="2011-04-05" version="1">MSERDLKRIEVLTEILAGRRTVESGAAVMGLAWRQTFRLLARYKELGVASVMHQARGRASNRQMNPDVREYAVELVRTRYADFGPTLAAEVLLEKHGIKVGRETLQRWMVEDGLWLSRKQRRTFHQPRLRRESYGELVQIGGSEHRWFEQRGEPCTLLVFIDDATSRLMQLRFVPSESTSSYFEALRGYLETHGCPVAFYSDKHSVFRVNRSEAKGGTGMTQFGRALTELNIEIICANSSQAKGRVERANRTLQDRLVKELRIENVSSIEAGNAFLPDFVGRFNERFAIRPAKTNDLHQQLRLKPDRLDDVLCHREQRHVGEQLTLACDRKQLILDRSTVSDELSGQYVHPYDFPDGRLEVRWKGRVLPYRTFHKDQRVNAAAIIENKRLGHALSPIKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H2</accession>
    <name>E8X7H2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71406">
        <property type="protein sequence ID" value="ADW71406"/>
        <property type="gene ID" value="AciX9_4460"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4460"/>
    <dbReference type="HOGENOM" id="CLU_2601154_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="9325" checksum="1BD282BD873038CF" modified="2011-04-05" version="1">MAKRKLFWVRISLLVLVTLFGLDALYWLLFFLWRSAADPAQNALWHSRIYLWSATGVTALFAWVALVFWILRDRKRTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q4</accession>
    <name>E8X7Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4556</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71488">
        <property type="protein sequence ID" value="ADW71488"/>
        <property type="gene ID" value="AciX9_4556"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4556"/>
    <dbReference type="HOGENOM" id="CLU_2954057_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6873" checksum="8BE38021BACCF811" modified="2011-04-05" version="1">MIQVKHFPNQFTILRTTEQNLIFVLPLIGIHLFAVFTGLLKWPQLIQWPADRKSLALDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X801</accession>
    <name>E8X801_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71585">
        <property type="protein sequence ID" value="ADW71585"/>
        <property type="gene ID" value="AciX9_4655"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4655"/>
    <dbReference type="HOGENOM" id="CLU_1854254_0_0_0"/>
    <dbReference type="OMA" id="GMCATCY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="14416" checksum="50BA8713732AD164" modified="2011-04-05" version="1">MGLCSTCYTLKRQDEEYFGGLREAVLERDGYRCRVCDASGRDKWSIIVHHRRPGKSVLKLMLSLCPGCHAKVHRTKAVLSAMPPLLLELWREQHPKGHEQKQLDFSSRKPAAKLIPLFRDEKESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA9</accession>
    <name>E8WVA9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578612.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0210"/>
    <dbReference type="EnsemblBacteria" id="ADW67284">
        <property type="protein sequence ID" value="ADW67284"/>
        <property type="gene ID" value="AciX9_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0210"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="508" mass="54161" checksum="D2F6B8A78DF437EA" modified="2011-04-05" version="1">MLLDRRRFNSLSLAAAITGFGAGPLASEAAASVAQPPAPETSAEELCYMTIAQAGAALKAGKVTSVQLTRACLDRIDTYNGKLAAYITVLHQGALAQAQRMDDEMKAGKYRGPLHGIPIGLKDNIDTANIRTTAASAACESRIPTEDAPVATRLREAGAVLLGKTNMGEFAATLTSFYGIVRNPWDLTREPGGSSSGSGVSIASGLCFGALGTDTGGSVRHPAHFCGVVGFKPTYGLVPIRNIIPLTFSLDHCGPLTRTVEDNAIMLNAIAGYDPADISSRDHAKEDYVAALKQPVHGFKLGRPSAGFDVLDPEVEALVNTAIALLVTLTKGIQDVNMPDPVLATWTSLGAETYAWHKPQFEATKNLYQPANRAMLQALADKDGGSASSYVDLSWKLQALRRTIDSHFKEVDLVVLPTMVNPAHKLDFVRPPDYNWHDYTNSPEYNAYGIPAISVPCGFTRGGLPVGLTIAGPTFADGKVLALAHAYEQATQWHLKRPPISPTMEIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK1</accession>
    <name>E8WVK1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-triphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579771.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1390"/>
    <dbReference type="EnsemblBacteria" id="ADW68449">
        <property type="protein sequence ID" value="ADW68449"/>
        <property type="gene ID" value="AciX9_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1390"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_3_0"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="22485" checksum="C5BBED3FE30E2187" modified="2011-04-05" version="1">MPLTLYIATSNPGKLRDFAHAAANQEDQTGTVTILPVSNLSSIPEPIEDAPTFEGNACIKALAYSVLAPDQIVLADDSGIELDALAGAPGVRSARFAEDENFPATPGQTKDDRNNQALQARAAHLTGVQRRARYRCVIAAARNGEIIANGTGSLEGILLESPQGKEGFGYDPYFLVPETNQTMAELDPATRLTLSHRGRALRDLLPKLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV6</accession>
    <name>E8WVV6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpxC</name>
        <name evidence="13" type="ordered locus">AciX9_3714</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582024.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3714"/>
    <dbReference type="EnsemblBacteria" id="ADW70715">
        <property type="protein sequence ID" value="ADW70715"/>
        <property type="gene ID" value="AciX9_3714"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3714"/>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046528_1_0_0"/>
    <dbReference type="OMA" id="IVFYRSD"/>
    <dbReference type="OrthoDB" id="428602at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="308" mass="33580" checksum="8953BC3DB7CF9D0A" modified="2011-04-05" version="1">MQGPAHSEQTIQSEICFNGVGLHSGAEVSMRLIPAPAGSGIVFRRSDLDNFEIPATGRNVAKVSYATSLMRQSVLIQTTEHLLSALIGFGVDNVIVEVDNLEVPILDGSALPYVQAFQSVGLKTQRRRREYLKILKDVEVRDGSKFIGVYPGEGYQIDYSIDFPAPIGCETFRGDLAIGDYANLIAPARTFGFMEDEAMLRNMGLIRGASDACAIILNKHGVQNGPLRFSDEFVRHKVLDLIGDLALAGRRIQGKVVAERAGHAMHTALVQKLMRDRSAWVLAHGFDEITEPEPESSLGLLVLSPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW17</accession>
    <name>E8WW17_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">AciX9_0249</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578651.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0249"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="ADW67323">
        <property type="protein sequence ID" value="ADW67323"/>
        <property type="gene ID" value="AciX9_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0249"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_0"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="381"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="554" mass="61539" checksum="2AA70976AA38A20A" modified="2011-04-05" version="1">MSAKYIFVTGGVVSSLGKGLAAASIGCLLEARGIKVNLMKFDPYLNVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTHAKLTRDNNLTTGRIYEQIITKERRGDYLGKTVQVIPHVTNEIKNAMRKVAADCEVAIVEIGGTVGDIESLPFLEAIRQMRQELGRENTCFAHMTLIPWIAAAQELKTKPTQHSVKEMLSIGIQPDILLCRSDRAVPREMRSKIAAFCNVEEKAVIIARDVPSIYEVPLNLAEQNVDTLALNYLRIDSKAPDLTKWQDIVQRAYNPQDVVSIAIVGKYVEYEDSYKSLKESLVHGALSHNLKLQVTWIEAEGLEAHNYPEQLAGFDGILVPGGFGKRGIEGMLNAIRYARENTIPYFGICLGMQTACIEYARNVCGLTGANSGEFDPATPHRIIYKLRELTGVEEMGGTMRLGAWACVLEPDSLAHKAYGTSEISERHRHRYEFNREYEAVLTGAGLRLTGTTPDSTYVEIVEIPGHPFFLGCQFHPEFKSKPLEPHPLFRDFVGASYKHRQENATSLIHEGHTPHEAVPAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW21</accession>
    <name>E8WW21_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578655.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0253"/>
    <dbReference type="EnsemblBacteria" id="ADW67327">
        <property type="protein sequence ID" value="ADW67327"/>
        <property type="gene ID" value="AciX9_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0253"/>
    <dbReference type="eggNOG" id="ENOG5031XTG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592248_0_0_0"/>
    <dbReference type="OMA" id="WFFSNLP"/>
    <dbReference type="OrthoDB" id="1838338at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="18750" checksum="133DD146A7E79FB3" modified="2011-04-05" version="1">MTLLNAPAYNERKERTIKATIIGSGLLVALIIIIGVGGFLVGHGWFFSNLPAEHRVSTFFDALEANNYDKAFGIYTNDADWKQHPDQHKDYGIDRFTEDWTKDSPADGPIISHHVDISKTDGTGNFGSGIIVAVRVNSAKTQNKKLFMYYVRKDGTLTWPAFHQLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW39</accession>
    <name>E8WW39_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0272</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578673.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67345">
        <property type="protein sequence ID" value="ADW67345"/>
        <property type="gene ID" value="AciX9_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0272"/>
    <dbReference type="HOGENOM" id="CLU_2734373_0_0_0"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7702" checksum="F5955F3964A1AADA" modified="2011-04-05" version="1">MDALLSIDEAARRLGGLSKYTIHAWLSSGKLKRTKLGSRTMIRESELERIANEGEGGKSAGRVREQASDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH5</accession>
    <name>E8WWH5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ordered locus">AciX9_2614</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580954.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2614"/>
    <dbReference type="EnsemblBacteria" id="ADW69639">
        <property type="protein sequence ID" value="ADW69639"/>
        <property type="gene ID" value="AciX9_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2614"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_1_0"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24120" checksum="F19955244E4F7F47" modified="2011-04-05" version="1">MAGILFIISAPSGSGKSTLVSQLRTLVEGLDFSISYTTRAPRGSEEDGREYHFTTRERFEEMIAAGEFLEWAQVFGNYYGTALSALDHAKREGKDLLLDIDVQGAVQVMKKLPAAVSIFILPPSPQVLERRLRNRSEAEHVTAEDVIARRLAEAQKELDRVGEYKYALVNDVLDDAVTEMKAVVLKERGEPLADGELAASCETSARSARLVAALGSFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS0</accession>
    <name>E8WWS0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0326</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0326"/>
    <dbReference type="EnsemblBacteria" id="ADW67398">
        <property type="protein sequence ID" value="ADW67398"/>
        <property type="gene ID" value="AciX9_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0326"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_0"/>
    <dbReference type="OMA" id="HFLICAN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="201" mass="22465" checksum="9FC5563953AD10F4" modified="2011-04-05" version="1">MTLGADSCSLILVMARLKSSEKRDAILQAAVGEIAEAGLGAATAKIARRADVAAGTLFTYFVNKDELLNELYLELKGEVYSRVNESFPHKGSLERRVKHIWVSYLGWAVEYPLKRKVSVQLNVSDVITAATRSRAAEARGLIDRTLRELGERESLRELPSGFAVAMMSSLQDAVMEFIAKKPKQQEMLTERAFEVFWRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWZ0</accession>
    <name>E8WWZ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotide adenylyltransferase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1498</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579871.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1498"/>
    <dbReference type="EnsemblBacteria" id="ADW68551">
        <property type="protein sequence ID" value="ADW68551"/>
        <property type="gene ID" value="AciX9_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1498"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423311_0_0_0"/>
    <dbReference type="OMA" id="MADYIYL"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="654" mass="71072" checksum="818BE5CB32732D92" modified="2011-04-05" version="1">MADYIYLLENRLSAAQRAALLAVRELAKAKSLTLFLVGGAVRDLTSGSPVRDLDVVVQGNALKLNKDIEKAGGTIVGQSDLGQALFVRFPGSVRMEIGSTLSVTFPKPGKPVHKPATILEDLRRRDFTANAMALSLNDGSYGLLMDPLNGVADIENRQLRLVSNYGFIEDPIRMVRAARYMARLGWTMDEKTQSRYETGQQEGYISALTDFPRGYETEEIVHEEDPLRVLNRLEAEGWMKHLAPYWTAAKVNVAELERLRETQTQLQMQGIHPDPAAANFPLLTAKLTPKELETLKASFPRKGFVTEIEALEAESKEFATQLGSKLAVLPSTSWKMISAAPAESVLWTAFSTKSGQLQAKFKSFYTEWPQVRQKIPYTLMQEMRIVKELPIYEELLEKLFFELMDGHLQTPEEMKAFLEPYSPPAPPPPVSTRRLKAAKAPKGRAKKVKVVDDAEDEDLDLPAIARVTDSDDDDDPTPDADPDSDDDSGSDSDSDDDEDMDADEPAPVKAPAKAAKAAPPTPAKKQAPPPPVNVAAVKSKPAPPPPAKKAALKTALKTALKTAAKTPVKAPVKLATKTAPPARAVKAVKAVAKPAPKKAVPAKQSVVKKATPKKAAPPAKKSVPAKKSAPVKKVPAKAVKAPAKKTPIKAGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX09</accession>
    <name>E8WX09_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1517</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579889.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1517"/>
    <dbReference type="EnsemblBacteria" id="ADW68570">
        <property type="protein sequence ID" value="ADW68570"/>
        <property type="gene ID" value="AciX9_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1517"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_1_0_0"/>
    <dbReference type="OMA" id="GGTHIYR"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="337" mass="35931" checksum="DA4F30C032DFA6B6" modified="2011-04-05" version="1">MNPFNYERATTPQQAIHAGAMHGAKFLGGGTNLVDLMKYEVEHPTTLIDINHLDLTQVTPSADGGVVIGALVRNSDLANHKLIVEQYPLLSQALLSGASPQLRNMATTGGNLLQRTRCYYFNDTAFAACNKRAPGSGCAAVKGYNRIHAILGQTDKGATSPETCIATNPSDMNVAMAALEATVQVEGPKGKRTIPFHDFHRLVGTTPQQDTNLRPDELIVSVTLPKARFAKNSHYLKARDRNSYAFALISVACGLELEGSTIKSAGLALGGVAHKPWRSPEAEKVLTGKSATAETFKQAAELALAGAKGYEHNAFKIELAKQGIVRSLTLAAQGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX72</accession>
    <name>E8WX72_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581029.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2690"/>
    <dbReference type="EnsemblBacteria" id="ADW69714">
        <property type="protein sequence ID" value="ADW69714"/>
        <property type="gene ID" value="AciX9_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2690"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_1_0"/>
    <dbReference type="OMA" id="TFVMESW"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="572" mass="62515" checksum="6F4F8F92D8D2BB2C" modified="2011-04-05" version="1">MPLEQPNASPAESSVNPASSGFAPLHIPLFRDRWIASTVSSLGTWMQDTAGTWLMTLLTSSPLLIALMQTAASLPVLLLGLLAGATADIFDRRKLLIFWQAWMLGAVGLLAVLTFLGHISPWGLLAFTFLLNIGSAMNNPAWQAIVPELVPRELIPDTVSLNAASNNLARAVGPALGGLMVAAFQRATMGAGSVFALNAVSFAGVIWVLVNWKRMPLFKSALPSERIAASIRSGLRYVRYSPPLQASLLRAFTYTFFVSAIWSLLAVVAKRDLHQGALGYGILNGSLGLGAVIAATQLPKVRRRFSADRIIAASTLYSVFTMVMLAYVRSPWIIIPVLIVSGSAWTSTMSTINTSVQLGAPAWVTARALGTYLMIFQGGMALGSVTWGFLAEHTTTPTALASSACGLLVTLPLVYRFHILQGPLPDHTPYQWKRPAPELVSPFGVDGATTGLGLDAEYHEGPVRISVEYRIEPERYVEFTHAIHQLRGVRLRDGALRWGIFREAADPSHLNETFVMESWLDYLRSRERMTAADQTIRDRVHALHASDERPRVTHQIYVREITPELKSPTQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX88</accession>
    <name>E8WX88_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein interacts with FtsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2706</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581045.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2706"/>
    <dbReference type="EnsemblBacteria" id="ADW69730">
        <property type="protein sequence ID" value="ADW69730"/>
        <property type="gene ID" value="AciX9_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2706"/>
    <dbReference type="eggNOG" id="COG0670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255435_0_0_0"/>
    <dbReference type="OMA" id="ASMFFHF"/>
    <dbReference type="OrthoDB" id="1947455at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="24446" checksum="5A3F6997B21ACA0C" modified="2011-04-05" version="1">MSYDVNRSLDPRTGTWSTLIDVPREETASLLSKVLAITSLGFLITAFGVRTAPVWSTLPGLIAVFALIFAISAARKANASLALGLFLLLTYFMGWEIGPLIHRYMQTVGPAIVFKAAATTGLGMAAMGIVAYLFNINYRRVTGIASAALLLLVLMGIASMFFHFLQPDTYSWLTLGVFTLLTVGDFARIRAGGDGQSAVSLSLSIYLDAINIFLAVLQLMGGGRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX91</accession>
    <name>E8WX91_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2709</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2709"/>
    <dbReference type="EnsemblBacteria" id="ADW69733">
        <property type="protein sequence ID" value="ADW69733"/>
        <property type="gene ID" value="AciX9_2709"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2709"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625240_0_0_0"/>
    <dbReference type="OMA" id="LCYGSGY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="44780" checksum="2A4EB457FAE486C5" modified="2011-04-05" version="1">MTQAELLALPEHQGQTKDSPAVGDLMDARNALKLSLTTLAFAGALAFSPQAASAQYNQGVQPYNNQDPQNYAAPAQQQYGQQQPYVNQPYGNNAYGVQTYGNQANPQYQGQAQQYQGQQPYGDPQQQQYGQQGPPTDPQDFVQQAPPPLPDYDQPEAPADGDIWTPGYWQWGGNGYVWVPGAWVEPPYTGALYTPGYWGDGDNGYFWNAGYWGPTVGYYGGIDYGFGYFGVGFYGGYWNGGRFFYNREYGHFGRAFGGHFYSQHYAGVGGIHPGGSSFASINRGRGFGINNRAGTFNQQGNSFRSQGFNGNNNAGNRGGIGYQGYAGNRGGFGGGTPAAGNNVRGATGTPFQGGGARGFSGNPGSNAGGGVHTAPSGGGNFGGGGGVRTAPSGGGNPGGGGGGFHGGGGAPAGGGGGGFHGGGGGGGGSHGGGGGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXB5</accession>
    <name>E8WXB5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0376</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578776.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0376"/>
    <dbReference type="EnsemblBacteria" id="ADW67448">
        <property type="protein sequence ID" value="ADW67448"/>
        <property type="gene ID" value="AciX9_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0376"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_6_0"/>
    <dbReference type="OMA" id="ENGTIMM"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="275"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="371" mass="39960" checksum="026FAAD8BB338280" modified="2011-04-05" version="1">MVNKLILANLGHRPLRTFLSVLAIGVEVTMILTLVGVSYGTLDASARRARGIGADVFVRPPGTSAMTLSSAPMSEKIIPILGAKPGVALATGTMVQSAGGVFESIQGVDFPTMNKMAGGFKFLEGGPFQQPDDILVDEYYAKQKKVHPGDYVKLINHQWRVAGIFESGKLARILAPMSTLQALTGNEGKISAVYLKLDDPAHADAFVQRLKQDLNPGDPDHGYQIMTVEEFTSQLTVNSVTMLKDFIYVVIGIASIVGFIVVFMAMYTAVLERTREIGILKAVGAGPGYILNILFRETILLALIGTAFGILMTYGTQWLMLHAVPASLVQETVYSWWPRAAAIAIVGAIVGTLVPAMKAVRQDATEALSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH1</accession>
    <name>E8WXH1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0432</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0432"/>
    <dbReference type="EnsemblBacteria" id="ADW67504">
        <property type="protein sequence ID" value="ADW67504"/>
        <property type="gene ID" value="AciX9_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0432"/>
    <dbReference type="HOGENOM" id="CLU_3184266_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="46" mass="5411" checksum="FB8AE5CA43A80637" modified="2011-04-05" version="1">MSMVESEREMVRKTAEKPAEESFTSLQPTYEDSVPPDPENDWEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH5</accession>
    <name>E8WXH5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0436</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0436"/>
    <dbReference type="EnsemblBacteria" id="ADW67508">
        <property type="protein sequence ID" value="ADW67508"/>
        <property type="gene ID" value="AciX9_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0436"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_0"/>
    <dbReference type="OMA" id="SGYVHEM"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="24388" checksum="2E1D0611EECA30C0" modified="2011-04-05" version="1">MNGSIRTLFWDIGGVILTNGWDRNQRKRVLSRLGVDMEAYEEAHERANYYWERGLITAKEFFAQTVLTPNPELDLTFEIVWPQVCAESKVLHPECLDMLAELKGQGRYRIATLNNESRELNGYRLDAFKMRSLFDYFICSGSVHEMKPMPGIYRSAVDISGFEARTALFIDDKEENCEAARAVGMNAIRFESPQQLCLALADYDVHVSSLEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI8</accession>
    <name>E8WXI8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1551</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579923.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1551"/>
    <dbReference type="EnsemblBacteria" id="ADW68604">
        <property type="protein sequence ID" value="ADW68604"/>
        <property type="gene ID" value="AciX9_1551"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1551"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="YRAVVMS"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="467" mass="50755" checksum="F728B060C99CF711" modified="2011-04-05" version="1">MQEKVLIVEDEIHARTGLAELVASWGYRTECAADGAEGLDMVTRWSPAIVVTDLKMPRMDGMELLNRISERPERIRVVMLTAQGSIESAVEAMRMGAYDYLPKPVEPARLKAILQSASRQVEADEDVETPIRVAKSENTLGDMVGTSPEMKAVFKLIERVAPSNVSVLVTGESGTGKELVARALHDLSGRRNKAFVAVNCAAIPETLIESEIFGHEKGAFTGALERRAGCFELAEEGTLLLDEIGEMPAATQAKLLRVLEDRKLRRLGSKTETPVDVRVVAATNKDPERAVSAGELRGDLYYRLNVFNIQMPPLRAHVSDVPIIAEKMIADMNERHGCSVTGASEELMSRLLNYKWPGNVRELRNTIERAVILAGKGLIGVEHLPPHFGEAGFAPKASGAPAAQGPALSDTAVHVEVGTTVDEAERQLILKTLTSTHNNKTRAAEILGVSTKTLQNKLKEYAAAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ8</accession>
    <name>E8WXJ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579933.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1561"/>
    <dbReference type="EnsemblBacteria" id="ADW68614">
        <property type="protein sequence ID" value="ADW68614"/>
        <property type="gene ID" value="AciX9_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1561"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_1_1_0"/>
    <dbReference type="OMA" id="AKAWWDS"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="171" mass="18517" checksum="86A5D3A2DB281B13" modified="2011-04-05" version="1">MSATSETHDLSGQDAVKKIGELIKDVRICMMVTAGSDGSFDSRPMATQATEFDGTVYFLTRGDSGKVGEIQQDQHVGLIYSDPSNHNYVTAKGKASVSHDKAKIHELWNPMFKAWFPEGEDDPEVTVIKVTVSEAQYWEASSSKLVFGIKYLAAAVTGGKVDVGETGKLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL0</accession>
    <name>E8WXL0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1573</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1573"/>
    <dbReference type="EnsemblBacteria" id="ADW68626">
        <property type="protein sequence ID" value="ADW68626"/>
        <property type="gene ID" value="AciX9_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1573"/>
    <dbReference type="HOGENOM" id="CLU_3365237_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="35" mass="3777" checksum="D2850D027A66F08F" modified="2011-04-05" version="1">MVIVMMTAVVVVLSAGRDNGTGKHNQTKYSEQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL8</accession>
    <name>E8WXL8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1581</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579953.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1581"/>
    <dbReference type="EnsemblBacteria" id="ADW68634">
        <property type="protein sequence ID" value="ADW68634"/>
        <property type="gene ID" value="AciX9_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1581"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_1_0"/>
    <dbReference type="OMA" id="ADYSIVI"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="341" mass="35534" checksum="0380C76723F26A67" modified="2011-04-05" version="1">MLLEGIFLPLTTPFRPEGRLYLPKLEYNVDRYSRTPAAGMHILGANGEADGLTDHEACEVLGTAIAAAAKEKVMIAGVGRESVFATLALVEAAAAAGYDAVSLGGPAFAQDGGMRLEVVTYFQAVADRSPLPVVLVSRDGRELGTELIGELAGHPQVIGVIDDSDRVGEIGAVTTGVSREVEVTTVFAAATGRMSRKGASGDFVSAASLGGGTALTVAAGPAIKTRRKKVGFQVLAGKTAGMLGAWENGAVGAVPRLGAAAPQACCEVFQAWKDQDPELARVKQERVLEVAGRMEGFGGVAWSKYGADWNGYFGGRVRLPLLGLTGEKRGELEEMLGGMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY36</accession>
    <name>E8WY36_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FUSC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0503</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578903.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0503"/>
    <dbReference type="EnsemblBacteria" id="ADW67575">
        <property type="protein sequence ID" value="ADW67575"/>
        <property type="gene ID" value="AciX9_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0503"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013315_2_0_0"/>
    <dbReference type="OMA" id="MRLWVTH"/>
    <dbReference type="OrthoDB" id="1338660at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="80"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="715" mass="77754" checksum="7500417B71AEA671" modified="2011-04-05" version="1">MGWRSLAARMRLLRPSSAPVSLRSLQWSRGLRGGLAVGVSIVGSHLLGRAEGWVALGSFYVVLADNGGPYRSRLKTIATLLVGGLCSLVLGALASGNVASMVAMTLAVCFAYTFARALSQYVASTSVLILVIYFAMLSPNHQSAHALGNAALLFCCGWLWGASLSLFFWPLDPFRPARQAVAQCYRTLSGLAGMVAEDARAEAAVGLRTPMVLQHRRLRLEIEAARRALEQTKARSAVRTIRARNLSVLLELADIFFASTIRAGELLELASGAECERIREWTRGMGAAYAGVAEALVKRPQGDELGRMVPESEADVARAAGSPIFEHLAAERRDGRETLLLAVDAVDAIWSGVERIGSETAVSELQQMTEAGRGWADAVRSNWSFRSVMMKHALRVALVGAADAVIMRVVHVNHGFWLAMTSLIVLQPNVAHTMQRSLQRVRGTLAGGLLAALLALSLQWPPLLIAVIVLFAVLTCAFYAVDYGWYCFFLTPTFVLMSLPRVHDWHFAAVRVGLTLLGVAISLGAMRVLWPETERMDLGRFFANCCAAEAAYARAILALWPLRGTAGERGARQFVASRRRACGLASNDAEECVERILLEPVALSRRGVSEEMEERREERWQHELTFVTYTRRLTQSLLSFARLAHGEADTAVRLEALAVRLEGLGQRLASGDGGGLAARASGPVMESEDLPHVQIRRLERQVGVLEGAVSAAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD8</accession>
    <name>E8WYD8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2821</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581159.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2821"/>
    <dbReference type="EnsemblBacteria" id="ADW69844">
        <property type="protein sequence ID" value="ADW69844"/>
        <property type="gene ID" value="AciX9_2821"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2821"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_0"/>
    <dbReference type="OMA" id="DMNTRDT"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="34166" checksum="7AFD054AF91B11D2" modified="2011-04-05" version="1">MSILVVGSVAFDTLETPSGKANKILGGAATYFSLAASYFTDVRVIGVVGEDFTAEHEAVLTKRGIDTRGIEHADGLSFHWTGSYSGSLNEAKTLGTDLNVFATFSPKIPDAYKDSEYLFLANIDPVLQAEVRKQMPEVKMVCGDTMNYWIADHNENLKKVLKELDVLLINDGEARMLAGEQNMVKAAEAVMAMGPKALVIKHGEYGASAFFCDRSFAGTDGIAKPFRAPALPLSEVVDPTGAGDSFAGGFYGYIASQPKLTPGVFRRALFYGSVMGSFAVEKFGTERMQELSREEIEKRFGLFMEISHLEHARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL9</accession>
    <name>E8WYL9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0545</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578945.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67617">
        <property type="protein sequence ID" value="ADW67617"/>
        <property type="gene ID" value="AciX9_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0545"/>
    <dbReference type="eggNOG" id="ENOG502Z8KB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879789_0_0_0"/>
    <dbReference type="OMA" id="WDFGVHP"/>
    <dbReference type="OrthoDB" id="816456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="37413" checksum="EC8788C5BB13482F" modified="2011-04-05" version="1">MRWLGWVLAVGMVGTGVGQRQVLPVDPAGAPHRLRLILKDGSYQMVMSYKVVGKRVVYVSAERGGETEEIPVELVDLPATEKWVKSHEAAKEGAPVVAQEPVLDPELAKEEADRAALTPEVASVPPDGSLRLAIEDSVLALDTFHGGPELVPLVQQQSDLNKKTGHGFLKGVVNPRSAAHQVVQLKGEKADVQMHVDKPEIYLRIGGDVDLPTGAGAITVDTHGADNRPAKGPDPAESEYVIVRVDVRQDARIVTSFNAGQLGIKKQQDVIETVKTPLAGGHWMKLVPKESLLIGEYALVEVVEEDQINLGVWDFGVHPTAAENRDVVRPEKKRAVRLERRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP0</accession>
    <name>E8WYP0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0567</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578966.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0567"/>
    <dbReference type="EnsemblBacteria" id="ADW67638">
        <property type="protein sequence ID" value="ADW67638"/>
        <property type="gene ID" value="AciX9_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0567"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_0"/>
    <dbReference type="OMA" id="LDKYATH"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="22515" checksum="6D7EBD27F7D353D7" modified="2011-04-05" version="1">MPNPIRIMLVEDHQMVRQGLVSLLSSTDELEVVGAVGDGAQAVELFATLRPDVTLMDLQLPKLGGVEAILKIRQSFPEARIIVLTTYDGDEDIYRSLQAGAKGYLLKGMPFDELLKAILAVHAGKSRIPSPIAEKLADRLSGQQLTARELSVLERIVAGRANKDIAADLFISEATVKTHVNNLLSKLGVADRTQAATIALQRGFVHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ3</accession>
    <name>E8WYQ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0580</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578979.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0580"/>
    <dbReference type="EnsemblBacteria" id="ADW67651">
        <property type="protein sequence ID" value="ADW67651"/>
        <property type="gene ID" value="AciX9_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0580"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417853_0_0_0"/>
    <dbReference type="OMA" id="WNPHPWH"/>
    <dbReference type="OrthoDB" id="321272at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="695" mass="77055" checksum="30E9321B310C828A" modified="2011-04-05" version="1">MTDSRQGILAAAEWLLLVVFTCVLAVHTLPQAWRTLNTDFPNYYLTARLNHEGYDLSQAYDWRWFQREKDHHGIDQRLVGFAPITPFSTLFVWPLTSLAPLPAKHVWLLLQLALLVPISLLLRSLTAQPMRRILLLAAGSYPLHRNLLYGQFYILLLGILVLACWTYRRRMSAWAGALIAIAAMTKVFPVIFLLYFIRKRDWRALGAALTTLCVCGLLSVSIFGWSIHRTYLQTVLPWTLRGETLPPYILTGSSLSALLHRLFVYEPQWNPHPWHNAPMAASILGTVLQMLLVAAALLAIRSGGEQDVASRSHAPLEWSALLCVTLATSTSPASYNFILLLLPVLALCAMTQKRRPQIALAAVALYFAIGYPNWNTSDTSGLHAVLHVPRLWLLILFSLICCRAAAGISLRARLWHRSNIPWASALVLLALAGVVSGIRHQRGLYDDYAFRLPMRPDVFLAADPLDDAGRVKSVSMLPAGYRVLEDGVRDSVGTPGTDQLSFAINRGADWLEEAGLRSRLISQHGPLPGTIDQARSPFVPADGQGLAYVRDDHGRGRVYLHLSTYEKPLTPLWMSVLEGASAKDGIMAVAATQGEEASQIFLLQPGGVPSPSGLGEARYPAFSPDGHWLAYSRLVNGAWNLWLLDRHTQRAHPLTEAPCDQVEASWEPDSKTLLYASDCGRALGFTAICRRRIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT3</accession>
    <name>E8WYT3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1721</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580088.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1721"/>
    <dbReference type="EnsemblBacteria" id="ADW68769">
        <property type="protein sequence ID" value="ADW68769"/>
        <property type="gene ID" value="AciX9_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1721"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025132_0_0_0"/>
    <dbReference type="OrthoDB" id="539516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="675" mass="72389" checksum="431DDFA964C780A8" modified="2011-04-05" version="1">MDRRSWPKVAYVFAVAALFAVLAGELWLSVRSMSQTADEAAHLYSGYEYWTARDYGLNPEHPPMLKLVAAMPLLGMGLKVPQGAEAETSKMQEYVGGGEFLYGNDAGRVLFRARVAASVFSLLLAAMVFAAAYEMFGAGTGLIALVLCVFEPTLLAHGALVTTDMAASCMIFAAMYALYRYEKRPGIGRLLVVGVAVGLALAAKFSSLLLLPMFGVCLLLEWLKERRRLRAGGEVAQGFGGWKRVLGWVGAVLVAWVVLWGFYRFTYAARPGGLQLAPTLAAYAAMLGPTGKAGLIMAAARMHLLPEGYLYGLVDLQIFGGALPSFLLGTVHPGPTKMYFPVAFVIKSTLAVLALLVGLPFVARGKGGRYWRELVFLLVPVVVYLAVSLNAPENIGVRHILPVFPFVMVLAGWSAGLIMGWGRVGAAIAGVLLVVHVGSSLRAFPDYLPYANEAFGGPARTYRVLTDSNVDWGQTFLKTSDYLRKNKVEDCWYAVGLGVSFVDHYRLNCRPLPSGFGRVTGMQLPVIPPTVHGTILVSAVEASGLFWGNGVLNPYGELLKRRPDDMIGDAVLVFRGDVALPLASAEAHSSASSFLLRRGRLEEALGEANLAVAGSGVAPDIRVNLGAVLLTMGRKAEAEAAFGEARRLAGQYDPEGVQHTDQVIAGLESAVQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV8</accession>
    <name>E8WYV8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1746</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580113.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1746"/>
    <dbReference type="EnsemblBacteria" id="ADW68794">
        <property type="protein sequence ID" value="ADW68794"/>
        <property type="gene ID" value="AciX9_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1746"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_0"/>
    <dbReference type="OMA" id="DQMVMSP"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="44258" checksum="8A0D8785AB0593FD" modified="2011-04-05" version="1">MTTSAEVKTRPTPNVVGATTALVLLTALNFVNYIDRYILPGVQEQVKGEFHISDGQIGSLTLWFMIAYMAASPITGWLGDRFPRKPMIVVAALFWSGINLLTATVHSYGSLNIRHAALGIGEASFGIFAPAMLADFYPEDQRNRVLTIFNIAVPVGAALGYLIGGTVGEHFGWRMSFTVSAVPGIIIALLIAFFMKEPERAGSKDDKAKVEKGTVLSLVKNPAYLCSILGYAAVTFTLGGISWWMPSFLQRVDGRSMSSAGFIMGAITVVTGLLGTICGGVVAQRWSKKNPAALYLVPMWGALLAFPPAMCCFFGPKALILPSLALAIFLIFLGSGPVNAATVNAVQPNVRATALAGQLLMIHLLGDAPSPRIIGVVSDHSNLAMGLGSTLVTLLIAAVIFFIGSRYAKPLQHEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ00</accession>
    <name>E8WZ00_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase and metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2892</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581230.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2892"/>
    <dbReference type="EnsemblBacteria" id="ADW69915">
        <property type="protein sequence ID" value="ADW69915"/>
        <property type="gene ID" value="AciX9_2892"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2892"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344781_0_0_0"/>
    <dbReference type="OMA" id="ERDETSH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="229"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="679"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="820" mass="90111" checksum="727D3BE33D854382" modified="2011-04-05" version="1">MPLRVRLLITLTILSAVAATVLAARQPSHSWPQFGLLLVAVLLSSGLKVQLPKGDGSMSLNFPFILLAIMQLSPLQAIILAALSVVVLGRIKVKKFFTLVQTTFNVANSMCATAAASATYAFQIRHHGPPAPALAIAALVYFFCSTATVAMVIAWCKAERAIPFWRAEFPWYLPFYIVGAALAAIAQHVTANFGWATSLLLIPMVYTVYRSYQGQMNRIKEREQHYEQTEALHLRTIEGLAMAIEAKDQNTHDHLFRVRSYVNEIGVALQLSKLEMKALQTAAFLHDIGKLAVPEHILNKPGKLTPEEFEKVKIHPVVGAEILERVRFPYPVVPIVRSHHEWWNGTGYPDGLKGEDIPIGARILTVVDCFDALASDRPYRKSLPPDEAMAIVKKMAGIQFDPGVVAVLEQRYTLLKQQADTEHERNFIPLNTDIEVWRGEAPGAGFERSDDDLQTLSLSDNSDTAELDQTAAFASLNLIAAASQEAQTLYEMSQGLGGSLSLKETISVMASRMRRLIPFDCCALYLPAGETLVAQHIDGECAKSFAAEPIPMGEGISGWVAQSGKAILNGNATVEPTYRGKAGEPGELRSALSIPLYNLQRQLLGVLTLYAIEAESFSRDHLRILQAMESKLSLSLQNAIQFKRAEKDAETDFLTNLPNARRLFLQLESELERCRTVGQDLAVIVCDLNAFKEVNDRRGHLAGNMLLSSIADGFRRGCTNVDTVARMGGDEFVFLLPTMSAEGSEARLREIAETVTQVAHTLGFDTRVSASLGAAFYPADGESAEELLALADRRMYLDKQAHYKTLEGTTSEHRGKAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ31</accession>
    <name>E8WZ31_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2923</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2923"/>
    <dbReference type="EnsemblBacteria" id="ADW69946">
        <property type="protein sequence ID" value="ADW69946"/>
        <property type="gene ID" value="AciX9_2923"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2923"/>
    <dbReference type="eggNOG" id="ENOG5031ZPU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140940_0_0_0"/>
    <dbReference type="OMA" id="KFIVCAG"/>
    <dbReference type="OrthoDB" id="1670851at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="14882" checksum="1A96DF089827EE79" modified="2011-04-05" version="1">MTTTNIQTPVRLARPETTSSAMTVVVLIAGWLIPGLGHVLLKKPIRGLLLFVSIVSMFALGIALQGKIYSPNTGDLLDILGFVGQLGNGILYALARMLDWGHPSVQIALADYGTKFIVCAGLLNVISAVDAHSLANGRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ69</accession>
    <name>E8WZ69_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578999.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67671">
        <property type="protein sequence ID" value="ADW67671"/>
        <property type="gene ID" value="AciX9_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0600"/>
    <dbReference type="eggNOG" id="ENOG50331ZE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723128_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="382" mass="42813" checksum="F2511ED70BDAA577" modified="2011-04-05" version="1">MYPTAHRFILILSICAAWVLISWASVFKYLSHGKAALTMVLGVVAIALGMHWLDRFNQRDRQIGVGWFVLLFLILTAAFAVLYPISLKHTLNAGSDREDALRLELSAILHHQYPYDAHTFLGNPPTPLPGALLLAAPFFAFGHIAWQNLLWFALFFIFTVHFFRHRATALFFLVLFLLFVPADLFDFTSGGDYLTNFFYLAIAVALLIRSLDLKSEASFLAALFLGLTLSSRIIYAIVLLPLLALTLQRTSRSRALALFIVVLLAASAVTFPIFTPHVFTHLSQQLGQSSPKLRYIPSALHPGWTLPLLAIVVGGTAFFIRMNLPRLFLIFSIASFVLLAPFVITFALHSEKLRYNFAYLSVSVLAFSLWAFSHYESHSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD0</accession>
    <name>E8WZD0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1770"/>
    <dbReference type="EnsemblBacteria" id="ADW68818">
        <property type="protein sequence ID" value="ADW68818"/>
        <property type="gene ID" value="AciX9_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1770"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105919_0_0_0"/>
    <dbReference type="OMA" id="QMATSDF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="22374" checksum="1059AC3569C337B6" modified="2011-04-05" version="1">MPLLIAAAAGLLLGAAFLDLLPEALDLGAKQRLGGADVLGLTLGFFLLFAAIESGLDALTEREAGAQKTLRRVAGGLLVFHSFRDGMAIGAAFAASHTAGYAVALGIGAHDLADGMNTIILTTRGEKARWPDYLFLGLDAMAPFVGGLLTVWWLISSRDAVILLTLAAGFFLQMATSDFLPQVRRHEGNRRWLLGAVVGGAGVIYLTNRLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZI3</accession>
    <name>E8WZI3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1824</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580190.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1824"/>
    <dbReference type="EnsemblBacteria" id="ADW68871">
        <property type="protein sequence ID" value="ADW68871"/>
        <property type="gene ID" value="AciX9_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1824"/>
    <dbReference type="eggNOG" id="ENOG50335E2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1684087_0_0_0"/>
    <dbReference type="OMA" id="MHATGRR"/>
    <dbReference type="OrthoDB" id="1962771at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233527" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="17402" checksum="4DA087C5E8B42910" modified="2011-04-05" version="1">MRFTLGTLALLILSATFIPCAAHAATADVIPDSAALMQLEQRAEHADPREQCFLYTELTHFYTEIAGQQIAAGDMDLAALTLKRIQHYAEIIHTGLTTDPKHSKKLKDAEMTMQRTSHRLGEYIHLVSTEDQATVKSTLKQIDRVNEELLATVFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK3</accession>
    <name>E8WZK3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="6" type="ordered locus">AciX9_2954</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581292.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2954"/>
    <dbReference type="EnsemblBacteria" id="ADW69977">
        <property type="protein sequence ID" value="ADW69977"/>
        <property type="gene ID" value="AciX9_2954"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2954"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_0"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="25167" checksum="13039249D5D6A9F0" modified="2011-04-05" version="1">MANINVVNLGGEKVGEFDLLDEVFNAEINDALLWEAVKHYRAAMRQGTAATKVRKNVSGSGKKLWKQKGTGRARVGSIRTPIWRGGGTVHGPQPRSYDYQFPKKKLMGALRSAISAKIQDGKFTIVDSFEVPEAKTKLYRQALTKLETGKTTLLVESSRKLEEKLYLGSRNLQGVELVLSSEVHPYDLLRYEHAVFSKDAIEAIQETLKKAISKRQHAANAEKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK8</accession>
    <name>E8WZK8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ordered locus">AciX9_2959</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581296.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2959"/>
    <dbReference type="EnsemblBacteria" id="ADW69982">
        <property type="protein sequence ID" value="ADW69982"/>
        <property type="gene ID" value="AciX9_2959"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2959"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_0"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="17491" checksum="55411A7609911165" modified="2011-04-05" version="1">MPRKGYIAKREVAPDPIYGSTLVTKFVNSMMWGGKKSTAQGIFYTAMTNLEQKGGDEALKLFKKAIENCKPLLEVKSRRVGGANYQVPIEVLPERRTSLAIRWLVTYGRARGEKGMVDKLTAELLDAANGRGAAMKKKEDVHRMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP3</accession>
    <name>E8WZP3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2994</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2994"/>
    <dbReference type="EnsemblBacteria" id="ADW70017">
        <property type="protein sequence ID" value="ADW70017"/>
        <property type="gene ID" value="AciX9_2994"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2994"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670708_0_0_0"/>
    <dbReference type="OMA" id="RYEITPR"/>
    <dbReference type="OrthoDB" id="821623at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="427" mass="47310" checksum="123F0981AB52DB23" modified="2011-04-05" version="1">MPRLPKPRRLRSRRPALARLTENLRRSRTFVGETRTRVTERIRRQRLLFTAILTAGLIVFALAIWPFTKDHLEAISVLQQVSQKPVPALIADLVSHPVTTQDLTLDTESGKVRARLYMPANNPNAPALIVLHGVHHLGIDEPRLEGFASAMASTGLRVLTPELPDIKDYHVDSTSIKTIGESTQWFAHKTGAPVGVMGLSFSGGLALLAAADPLYKKDFKFVFAVGSQDSMNRVAQYYRTNQDERPNGSTELLPAHEYGPLVLEYEYVEDFVPRQDIARIRAVLRAHLYEDKPAEATASLKLDERQKAEALDLMDAASPHTRSLIAAAAARHANELNGLSPGGHLRTLMTPVYLLHGQADNIIPSAETLWMASELPTITLQAMLVSPVISHLDMGTNPTLADQWHLIHFFALIMHAAETPTGRTPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP6</accession>
    <name>E8WZP6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2997</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581334.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2997"/>
    <dbReference type="EnsemblBacteria" id="ADW70020">
        <property type="protein sequence ID" value="ADW70020"/>
        <property type="gene ID" value="AciX9_2997"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2997"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_0"/>
    <dbReference type="OMA" id="FKFRGGW"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="33991" checksum="B764D872A1E7323D" modified="2011-04-05" version="1">MSQPTYVTLSEIQSAAARISGAAIRTPLTQLPGTSIWIKAESAQPIGSFKLRGAYNTIAQLTPEQLRLGVITYSSGNHAQGVAFAARALNSKAVIVMPDNAPQVKIDATRALGAEVVFVGPASSARKLKAEELSAAHGYTIIPPYDHPHIIAGQATCALEILQELPDVDLILSPVSGGGLLSGTATCVKQAAAAGLAKPTVQVWGCEPELAADAKESFDTKTLVEWPAALTTRTIGDGLRTQSLGQLNFHHILKFVDGIVTVTEDEIYAAMRRLLKDTDLVPEPSGAVTLAAALFHAHQLPAAAKTAVILSGGNIDPKLLESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A1</accession>
    <name>E8X0A1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ordered locus">AciX9_3062</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3062"/>
    <dbReference type="EnsemblBacteria" id="ADW70082">
        <property type="protein sequence ID" value="ADW70082"/>
        <property type="gene ID" value="AciX9_3062"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3062"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_0"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="52"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="31847" checksum="36C09856FDA7CFE1" modified="2011-04-05" version="1">MTPGKLKLGIPKGSLQDATIALFERAGWRIFASGRSYFPQIDDVEIECMLVRAQEMARYVEHGALDAGLTGNDWVLENESDVERITSLTYSKVSRGTVKWVLAVPEDSPFQKPEDLAGKIIATELVEFTKRYFAGKNIPVKVEFSWGATEVKPPTLADAIVEVTETGSSLKANRLRIIETLMESETQLIANKTAYADAWKREKINNISLMLNAAIAAQGRVGLMLNVAKEDLEAVSAQLPALNSPTVSQLSGGNGFALNTILDERVVREVIPKLKAAGATGIVEYPLSKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H4</accession>
    <name>E8X0H4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67838">
        <property type="protein sequence ID" value="ADW67838"/>
        <property type="gene ID" value="AciX9_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0769"/>
    <dbReference type="HOGENOM" id="CLU_215851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="4966" checksum="88367ABDB4BF7643" modified="2011-04-05" version="1">MTTLKTNNSNCKSKGNGKSNGKSNGKSNGKSNGKSNSQYRGSELRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P6</accession>
    <name>E8X0P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction-modification system methyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1951</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580316.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1951"/>
    <dbReference type="EnsemblBacteria" id="ADW68997">
        <property type="protein sequence ID" value="ADW68997"/>
        <property type="gene ID" value="AciX9_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1951"/>
    <dbReference type="eggNOG" id="ENOG5032YPG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162353_1_0_0"/>
    <dbReference type="OMA" id="LHGDWGD"/>
    <dbReference type="OrthoDB" id="2053795at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10472" checksum="157EE5AED6BF6B58" modified="2011-04-05" version="1">MPNFQCGRLVATPAALSAIEGSGDNLLLFLRRHLSGDWGDLGADDKRMNDAALKDGSRLLSRYDLKDGKPIYIITEAEGDNGNRESTCVLLREEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W6</accession>
    <name>E8X0W6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581463.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3138"/>
    <dbReference type="EnsemblBacteria" id="ADW70150">
        <property type="protein sequence ID" value="ADW70150"/>
        <property type="gene ID" value="AciX9_3138"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3138"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_0"/>
    <dbReference type="OMA" id="MIGFGRP"/>
    <dbReference type="OrthoDB" id="1064766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="37975" checksum="79A6B118911F5D3F" modified="2011-04-05" version="1">MPTLLDPIRIGDLELPNRVLMAPMTRLRASVQNIPTRLMTEYYTQRASAGLIIAEATPVAPMALGYAQVAGIWSEEQIKAWQDVTSSVHQHGGRIFLQLWHVGRISDPMFLHGALPVAPSSIAAAGHVSLVRPEKAFVTPRALETEEVYGVVEEFRLAAMNAQRAGFDGVEIHAATGYLVDQFLESGTNHRSDDFGGTLENRARLLLLIVDACTSVWGSGRVGVRVSPRGDRHDVSDANPAETFKYVARECGRLKLAYLHAREFRAADSLGPDLKRDFGGVFIANENFTFGSANEALARGEADAVSFARLFISNPDLPKRFANGAVLSSADPATFYAHGSEGYVDHPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X155</accession>
    <name>E8X155_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0853</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579246.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0853"/>
    <dbReference type="EnsemblBacteria" id="ADW67921">
        <property type="protein sequence ID" value="ADW67921"/>
        <property type="gene ID" value="AciX9_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0853"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_3_0"/>
    <dbReference type="OMA" id="MHISAAH"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="14499" checksum="5E884F8A5DFC28DA" modified="2011-04-05" version="1">MFEVTVEAGFSSGHYLRNYRGKCENPHGHNYKVFVTLVGAELDEAGLLLDFKLLKQVMRPVVDYLDHQMINDLKPFDEINPSAENLARYFFDNTATQLDEMTQGRVKVKDCTLYETDTSFARYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C2</accession>
    <name>E8X1C2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2031</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580393.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2031"/>
    <dbReference type="EnsemblBacteria" id="ADW69076">
        <property type="protein sequence ID" value="ADW69076"/>
        <property type="gene ID" value="AciX9_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2031"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="RYLLEMD"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="24520" checksum="00DD91CF1F45E5FF" modified="2011-04-05" version="1">MPAIQSPENEIPTEEIHPDVALVARAREGDASAFEQLVKQYDRQIFRVAQHITQNREDAEDITQDAFFKAYQKLDQFQGNSKFSTWLVRIAVNESLMRLRKRKTSKTVSMDEDVQTEEGSIPRDFAEWRPNPEQNFNQAELADILRKTIQGLPPGFRTVFTLRDVENLSTEETAEALGLSVPAVKSRLLRARLQLRERLSRYFKQGKKEGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J3</accession>
    <name>E8X1J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581540.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3217"/>
    <dbReference type="EnsemblBacteria" id="ADW70228">
        <property type="protein sequence ID" value="ADW70228"/>
        <property type="gene ID" value="AciX9_3217"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3217"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492406_0_0_0"/>
    <dbReference type="OMA" id="ICESEDR"/>
    <dbReference type="OrthoDB" id="924065at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="553" mass="60597" checksum="BB2702D1372D6F7A" modified="2011-04-05" version="1">MTKANGVSGVLVRHFFRRFFDSDTVSAEGDTVTTVVRAVSMAAAPGLMAAFFLQNQYPRRSLWGSIEDHYFFVLLTFVVLGAVAVFEWEMLFPDRLDFLILSPLSINPVKMLGTKLAALAGFLGLFLFASSVFGAIVLPAVSKGDFPRQMMAHATAVLMAGVFASLLFLAVGGGLICVLSASWFRVALPVVQTFSITALLLAMLHYFKCGDAMQAMLGHEPGMLRWLPPMWFLGVYESVLRGDGAPAFAAEMTKYAVRGTLVVSVAVAVTYPLAWVRMQRMAMEGSGGRYGEPSRWMTRVQHWVVRRAETRGVFHFIGQTMRRSSRYQVYLAMYCGTGFALAVACAVTYRLDGSGVPRAALATDGLRALTPLLLFWMVAGLRGAFAIPINLLARWVFRMAGVTMQVCADAGRQWALFCSVGVLGVVLAVLFAAGWDARQLVVQGVLGACLCVLLTDGFFFSGQSIPFNEARMPGRTSLPLVLTLYVGVLPAFILWMMQLDEAMEKRPVRLLMVVLGTALIHRLIVALRPGPEVEEEELEGYDGEFQLLGLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J4</accession>
    <name>E8X1J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3218</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581541.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3218"/>
    <dbReference type="EnsemblBacteria" id="ADW70229">
        <property type="protein sequence ID" value="ADW70229"/>
        <property type="gene ID" value="AciX9_3218"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3218"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_2_0"/>
    <dbReference type="OMA" id="GNTKIWG"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="488"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="569" mass="62272" checksum="6D6F517BFA7E93E5" modified="2011-04-05" version="1">MSTPYDAIVIGTGAGGGTLALHLAQAGKNILILERGPFMPQEKLNWDTSAVFLDNRYHTKEVWQDKDGKDLHPQQAYFVGGQTKVYGAAMFRMRAEDFGVIQHKGGISPAWPISYADLEPYYTRAEELFHVHGDLGSAPTVPGGFGSSFDPTEPFHSTKYPYPAFTNEPRMQSIQDDVRKLGINTFPIPLGLKRNEADPLAAPCIRCDTCDGYPCLVHAKSDSDINCIRQIMHLPNVTLMTNSRVVRLVTNAAGTAVTAVEVQHSGKSQASDNIATYTAGFFAVCAGAINSAVILLASANEKHPKGLANSSDQVGRNFMYHQADALLALSTDRNEDSYTKTWGTNDFYLKDSDPAYPYPLGQVQPVGSFHYEMMKGDAPPLTPGFVLETMKHHAVPWWLTTEDLPAAENRVTLHNATPLSVANVQPGLPGAHPSGDTGRTNQSEPVNDHAPHRVQLSYTPNNVESFDRLKDRWVDVLKRAGHATTHIPLHAYFKKRIPLEGVGHQNGTCRMGSDPTQSVLDAHCKAHDLDNLYVVDASCFVSASAVNPSLTIIANAIRISDHLLQERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P0</accession>
    <name>E8X1P0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
            <ecNumber evidence="5">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0891</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0891"/>
    <dbReference type="EnsemblBacteria" id="ADW67959">
        <property type="protein sequence ID" value="ADW67959"/>
        <property type="gene ID" value="AciX9_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0891"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_0"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="65"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="265"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="634" mass="69225" checksum="8CB301C8ABBC5CA3" modified="2011-04-05" version="1">METNSSSLRDREEKLSPVKLHAAQYAIVVILVVLVSGLWNLQVLGAENYKAAAEANRIRKVPVLAPRGRIFDREGRLIVDNYPSTSCYLLREQVKAGDIPVIAAGLHLTVDQIQATLKHFQTAPKYQPIPLKQDITPDEQAFIEAHKNELPELDTIDEQRRLYPRDGFAAHLVGYVGEVSEQMLANDPRYAAYDPGQVVGRSGVEQTYDALLRGEDGYREVIVNSHGKEVGKLGQKLAVPGQDLRLSIDLDIQRAAEQALEGKNGAIVAMDPHTGEIIAMASRPTFDPNQFSVRLTQSYWSSILNNPNHPLLNKAIQAQLAPGSTFKIIMSVAGLQENVAQDLKVNCQGGASFYGHFYGCDRHHGGVNINTAIPYSCDTFYYTLAYKLGIDKIAQYGREMGIGQKTGIDLPEEAAGIMPSEQWKMKNYHQKWFAGETISVGIGQGAVTATPLQLLRALSGIASGGVLRWPHVLLPGQVPAEMQNAVRDTFPGSGEKTIPLSTENWQLITDAMANVTSSPIGTAYPAHLEGIDFAGKTGTADVVSGRQKGSKNKDTLPNAWFVGMTPRRNPDFAVAVLWEHGYWGNNSARLAAQVIDAYVEKQRAKDHNLRTVEAVKTPEAAPEKAAVPVVPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S0</accession>
    <name>E8X1S0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplK</name>
        <name evidence="9" type="ordered locus">AciX9_0922</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4 6">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579313.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0922"/>
    <dbReference type="EnsemblBacteria" id="ADW67989">
        <property type="protein sequence ID" value="ADW67989"/>
        <property type="gene ID" value="AciX9_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0922"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_0_0"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="15315" checksum="1F2BB80F9481A75F" modified="2011-04-05" version="1">MAPKKITGYVKLQVMAGKATPAPPIGPALGQAQVNIMEFCKQFNDRTKEPSMAGLTIPVVITVYGDRTFTFITKTPPAAVLLKKAAGIEKGSGTPNKEKKGKVTEKQIIEIATQKMPDLNSTTVEAAARSIRGTARSMGIEITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X243</accession>
    <name>E8X243_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581598.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3275"/>
    <dbReference type="EnsemblBacteria" id="ADW70286">
        <property type="protein sequence ID" value="ADW70286"/>
        <property type="gene ID" value="AciX9_3275"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3275"/>
    <dbReference type="eggNOG" id="ENOG502ZNPU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2774532_0_0_0"/>
    <dbReference type="OMA" id="ASDIHYW"/>
    <dbReference type="OrthoDB" id="2081466at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022037">
        <property type="entry name" value="DUF3606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12244">
        <property type="entry name" value="DUF3606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8872" checksum="8C733EA538820798" modified="2011-04-05" version="1">MAQLPPHQEPLLSEPEHDGKHHHAPSHADEINPKLASDIHYWAQEFKVTGQILHEAIRVHGTSVAKVRSALEHHQVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X267</accession>
    <name>E8X267_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_3299</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3299"/>
    <dbReference type="EnsemblBacteria" id="ADW70310">
        <property type="protein sequence ID" value="ADW70310"/>
        <property type="gene ID" value="AciX9_3299"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3299"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_0"/>
    <dbReference type="OMA" id="EHKDGQR"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="93"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="298"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="532" mass="57708" checksum="65CA7C53B9281640" modified="2011-04-05" version="1">MNSATLEPQNETISNTSNQNFSNNNEAAAAPTRTSHEAIPVDVTAMNSEIDPTTGLPMLKGVHFADFNISASLKSRLAAGGFATPTPVQAKAIPPALEGRDILATASTGTGKTLSFLIPMIERMEANSEPSTRGKKGPIRSLILLPTRELAMQVLEAYAKINPQSKSDSVLVCGGLSENTQLDQLSRGPRLVVATPGRLEDFLRRRSVNLNFVEMLVLDEVDRMLDMGFLPAIRRIVGALPKTRQTMCYSATLDANITEIVRDYVQKPVRIEIGTTSKPSDQVELKVFTVMQDQKLGLLNQMLNEHEGTFLVFSRTKHGADRISKKLEKLGHVADVIHGDRSQSQRTSALKGFSTGRHRILVATDVAARGIDVRDIAHVVNYDLPGTTEDFVHRIGRTGRAGKKGVATTFVMPQERSDARKMERELKIKFEWKEADKNLEKEERNKPVDLSGPSDLMNMETRAWKTGDVSAERKATAPGASPYRGAGNGFRGRSGAGGGSGRPGGGFSGGRSAGRPNSRPGSSRTGPARRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X293</accession>
    <name>E8X293_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0958</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68025">
        <property type="protein sequence ID" value="ADW68025"/>
        <property type="gene ID" value="AciX9_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0958"/>
    <dbReference type="HOGENOM" id="CLU_1022185_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230588" evidence="1">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="26896" checksum="1AC144B0B89CB1DD" modified="2011-04-05" version="1">MRVRNIVGLFGMAVLAGFLSGCNALTAVTGIPTSLKAAIAGNWEVKTNATQAVTLPEIAGAFATTNGAVTATFHTLAANACMAPNTFVSATGTTDANGNLKLTSAAFNGSTLSLTGTLAADGKTLTNATYSVTGGSCGFPVVAGTAAVAATATQYAAITGAYAGNFTDSDGDVIPVSGNFTQSTAPDANGVYHLTGNATFPGNPCLTSPAIVDSTVTGSMLSTTYSQTANGMTNTVVANGTFNADASILTVTDWTISGACGSAHGTGLFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E9</accession>
    <name>E8X2E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1018</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579404.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1018"/>
    <dbReference type="EnsemblBacteria" id="ADW68081">
        <property type="protein sequence ID" value="ADW68081"/>
        <property type="gene ID" value="AciX9_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1018"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893605_0_0_0"/>
    <dbReference type="OMA" id="HNANRTL"/>
    <dbReference type="OrthoDB" id="1719713at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230592" evidence="1">
        <location>
            <begin position="27"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="32811" checksum="2221084D43FCC7DD" modified="2011-04-05" version="1">MMTSLRFVAPTFLATLLLVPSQPCLGQQVEPSSTGQSASLPPDNSVAANKDWAWSMLTTALNDTKHPDTRVQALAALGILGSTPRSLKLILDTLNDPDVDLRTAAILAAGQTKSPDVAADLRRMLDDKEPQVAFAAATTLWKMNDRSGEDILVAVVDGERSANPGLVNGTMHTMNRDLHHPSTLAKLGAMQGAGMLLGPFGMGITALEYMRKNGGNLSRVTAVEQIAENHTAPIRTKLIAALSDKDATVRVAAAKALATFHEPEVAIALADQFPDGRAPVRLTAAAAYLINTGSAIVSPKSSARSHSHKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F6</accession>
    <name>E8X2F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2136</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2136"/>
    <dbReference type="EnsemblBacteria" id="ADW69180">
        <property type="protein sequence ID" value="ADW69180"/>
        <property type="gene ID" value="AciX9_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2136"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_1_2_0"/>
    <dbReference type="OMA" id="AYIDCTL"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="36766" checksum="6057C3FFA0B46A3C" modified="2011-04-05" version="1">MSLYDPASLNIVLYGAWFLKISPNNRMLDRTLGPLFRMRIGEPQTGVQTAVQAEPASLVRMETEPEDRIERLELFELHSAVLPEPETRCVCVYLPECYESEPERHFPVFYLHDGQNLIDGRTSYIPGRTWRVGETADRMIAEGLVEPVILVGVANTGLRRMAEYTPTKDFRMGGGDGKLYGRLLVEELKPHIDHEFRTLRGAVHTGLGGSSLGGLISLYLGLGHPETFGQLAVMSPSIWWDHRSLLQFVKQARPRPETKIWLDIGTGEGMRHVRDTELLERLLIQQGWRPGEDLQTLIVPDAVHDEDAWAARFDQVLRFLFPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W1</accession>
    <name>E8X2W1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="15" type="ordered locus">AciX9_1032</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579418.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1032"/>
    <dbReference type="EnsemblBacteria" id="ADW68095">
        <property type="protein sequence ID" value="ADW68095"/>
        <property type="gene ID" value="AciX9_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1032"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_0"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="178"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW68095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="34258" checksum="6A0EDE358E601606" modified="2011-04-05" version="1">MSRIAVLGAGAWGTALAISLARRGGHDLTLWAHSAALSEQLIESGENVPYLPGFTLPADIQITSDLPAAIFEADILLSVTPSQHLRETIAHIAPLLTPNQIILSASKGIEDKSFLRMTQVIASITNNPCGVVSGPSFAQETAAGLPTAVVIASSVPQVAQTVQREFSSPSLRLYTNDDVTGVELGGALKNVIALSSGVIHGLGLGANTSAALITRGIAEITRLAVACGGRRQTLAGLSGVGDLVLTCTGSLSRNRQVGVELGKGRKLPEILAGMNGKVAEGVRSTAAALGLAARYGVEMPIAEQMDAVLHREKSPRDAIKDLMARPGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X9</accession>
    <name>E8X2X9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1050</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579436.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1050"/>
    <dbReference type="EnsemblBacteria" id="ADW68113">
        <property type="protein sequence ID" value="ADW68113"/>
        <property type="gene ID" value="AciX9_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1050"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472319_0_0_0"/>
    <dbReference type="OMA" id="SKMNAGM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="319"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="445"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="577" mass="62866" checksum="7117A5898F4D1945" modified="2011-04-05" version="1">MSLATLYTLGSIGSCVLICVFLGVTLLRAKREINRLRSELQEASEQQRSKDSLLTQRSELDTIKDEFISTVSHELRTPLTSIRGALGLLSAGMMGEVDAKAQNLLRIAVTNTDRLIRLINDILDLERMESGRAPLHVRRCSLRDLVQQSVETMTPMAQTAQVELTLALLSPPEGMYFDGDPDRILQILTNLLSNAIKFSPAQSIVTIQVEADLDSVLVRVADQGRGIPLEKLDTIFDRFQQVEASDARQKGGTGLGLAICRTIVLQHNGSIWAESNESHQRGPGATLLVSLPRTSRAQDGAATPRQITTSSLPPSGDGMIILCDDDAHIRAIVGEHLSQQGYSVLEADCGEKAIELAAANDVSAILLDLNMPGMSGWETLQRLKHSPATANVPVVILSVLSSGSSPAGGHKVSAAAQGWVQKPFNEHILLAELSRVLHTGEGPAHVLLVEDDLDLAAVVIAGFEEANVRVDHASTRQQAMEHCQLSRPDLLILDLHLPDGSGFSLVDWLRQQPELRSLPLVVYSGQEVSEGEMSQLRLGPTQFLTKAKIQPKEVEQLVLSIVQRLRVPDETLREVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X300</accession>
    <name>E8X300_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1071</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579457.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1071"/>
    <dbReference type="EnsemblBacteria" id="ADW68134">
        <property type="protein sequence ID" value="ADW68134"/>
        <property type="gene ID" value="AciX9_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1071"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_0"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="48570" checksum="08278E8C76ED1ABD" modified="2011-04-05" version="1">MIHPLDVIIHKRDGLTLTPEEIQAVITAVVTGKGITEAQIAAFLMAVFQRGLNTDELAALTKAMRYSGETFDASPLQTFTIDKHSTGGVGDKTSLLIAPILAAAGLAHPTPHDTPGICVPMISGRSLGHTGGTLDKLETIPGFNTQLSLTRFLEVLRTCGASLIGQTPTIVPADRILYALRDHTGTVESPYLITASIMSKKLAEDLKALVLDVKTGSGAFMKKYEDAKFLAKLMVETGEASGTRTVALLTTMDEPLGRYSGNWIEVLECVDIMQGRRHPMSADLIELSNILSGWMIYLAGGAETPEAGARISDHILATGKAYEAWLRIVEAHGGDTAIFTHPETFHKPLATRILTAETTGYLSTIDCTEAGWAVQRLGAGRTKPGDPVSAHAGLEVHAKLGQKVEAGQPLLTLFAEEESLLAEPHEMLRATYRITPEKPTLNPLIREIIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X376</accession>
    <name>E8X376_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2262</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2262"/>
    <dbReference type="EnsemblBacteria" id="ADW69300">
        <property type="protein sequence ID" value="ADW69300"/>
        <property type="gene ID" value="AciX9_2262"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2262"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_1_0"/>
    <dbReference type="OMA" id="LLKYPRW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="21085" checksum="F05AD0E4B4F3B567" modified="2011-04-05" version="1">MNDFVPQPAAPSEPTPAKGSLRAWLRDLLLSVGVSAFIIIFLYQPVRVEGTSMNPGLEDQDRLFVNKLAFHVGEIHHSDVVVFLYPHDHTKSYIKRVIAVPGDHIRIDHGRVYLNDQRLPESYVPTRFTDDRSQPELIIPPASYFVMGDHRSISSDSRDFGLVPRDLIYGKAAFVYWPMDQAGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X389</accession>
    <name>E8X389_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580629.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2275"/>
    <dbReference type="EnsemblBacteria" id="ADW69313">
        <property type="protein sequence ID" value="ADW69313"/>
        <property type="gene ID" value="AciX9_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2275"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134269_0_0_0"/>
    <dbReference type="OMA" id="HEFWALE"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025499">
        <property type="entry name" value="KdgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029883">
        <property type="entry name" value="KdgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="129" mass="14001" checksum="DA225A1D7A7A6302" modified="2011-04-05" version="1">MADETKSAGATLYHWDDIEAEQMSPTLTRQYVSGEKSMLARIVLKKGSVVPEHSHANEQIAYILSGALEFNVAGTVHTVRAGGVLVIPGNVPHSALALEDTVDLDLFAPPRQDWLDKDDSYLRGGAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X399</accession>
    <name>E8X399_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3394"/>
    <dbReference type="EnsemblBacteria" id="ADW70400">
        <property type="protein sequence ID" value="ADW70400"/>
        <property type="gene ID" value="AciX9_3394"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3394"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071591_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="275" mass="29688" checksum="E14620C6916547D5" modified="2011-04-05" version="1">MQRNAVFVDAGYLYSQSAVSLTGANAARPSLRLDEAELINQLKSLALNLSAGAQLLRIYWYDGAKNGMTAEQLVLADMADVKVRLGSINSAGQQKGVDSLLVTDLIDLARNQAISDAVIVTGDGDMRVAVQIAQSFGVRVHLVGLEPSSASQSQLLRQEADTVHEIPKIDVAKFMKHYGALAAIPAVPVAAKQPVEVSLTFENAVARSIHDILSQVSLDEMERLRGLVASNPSIPAQYDRPILGTCRHLISRDLTDSERRTMRKAAVQFIQGTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K4</accession>
    <name>E8X3K4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579518.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1132"/>
    <dbReference type="EnsemblBacteria" id="ADW68195">
        <property type="protein sequence ID" value="ADW68195"/>
        <property type="gene ID" value="AciX9_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1132"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077340_0_0_0"/>
    <dbReference type="OMA" id="YQIEVRL"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="25928" checksum="946B56D736BC68E4" modified="2011-04-05" version="1">MMNNPGRPRNLILARMPEEQFAAIARSLVPCDMPSGMKLAEPNQPVKHIYFPVSGLISIDALTAKGESVEVGVVGREGFSGMSGLLGEPQMAHSVIIQGAGAGLRIRTQILRDEFLKGGVFADLVHQFLYLQFVQTSQSALCNRLHPVDARMARWMLTASDRIESSTLNLTQEFLAQMLGSRRSTVTVAAGELQRQGLIDYTRGRIKILDRAGMESVACECYQIVRSAYVRVLGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N3</accession>
    <name>E8X3N3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1161</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579547.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1161"/>
    <dbReference type="EnsemblBacteria" id="ADW68224">
        <property type="protein sequence ID" value="ADW68224"/>
        <property type="gene ID" value="AciX9_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1161"/>
    <dbReference type="eggNOG" id="ENOG502Z8Z6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376572_0_0_0"/>
    <dbReference type="OMA" id="WTESGEP"/>
    <dbReference type="OrthoDB" id="1297289at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="231" mass="26268" checksum="82ECA859D789A485" modified="2011-04-05" version="1">MADQLYLSLFFPNFRFDSLPATMVSVLRQFARISGIPRVSASAAYPVSFNEAPIYQRQFVLDQRAAESEDTSASIIENAVAEATELLHEDTAYEFEMKWNLWLPQPQGEIEGAELDILWKPIPTTVKFLGFGPDFDDSTFEQNGHIRVDFGLDTPWIIEDPEDEENDLPILSFEDEEAKAEAAKHIKQNIEMLLAFTLSVEKHCNISSRLLWTESGEPLAEKLIARLQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N4</accession>
    <name>E8X3N4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OstA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1162</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579548.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1162"/>
    <dbReference type="EnsemblBacteria" id="ADW68225">
        <property type="protein sequence ID" value="ADW68225"/>
        <property type="gene ID" value="AciX9_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1162"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346449_0_0_0"/>
    <dbReference type="OMA" id="FEYDQPN"/>
    <dbReference type="OrthoDB" id="769031at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OstA-like_N" evidence="2">
        <location>
            <begin position="638"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="786" mass="81354" checksum="7E4D2CB4A6CDCAFA" modified="2011-04-05" version="1">MRFTLGKLRVVVVAGAVLLVAVVAGFVWYGQHSARQWFKRLPKQLGVDIKQETNGFTYSQSVKGKTVFTVHASKEVEHSNGKITLHDAGIILYGRQDGKADRIHGAQFEFDRPSGVMTAVGDVYIDLAAPAGKAGVGSGKDDESKLIHVKTSGLVFNQKTRVAATDEGIEFAAEGLKGTAVGADYDSGSGVVVLRSQVHVTGVRDGRPVDLVASHAVMDRTGNVANLTDAKYVSNGESVSGDRAVVRMGADSQPERLEAQGHVVLAGAGRGTMTGDKLDVGLNAAGQPKDAHLWGGVQYKDVTAVKNATGAAQDVRVSFDGAGRPTHALVTGGVRMDEAAGTGTRSLKAERVEMALTEVVKGRVEVKETTATGGAVLRMADAGAKGRSATDLSGDTLTARFAADGKKERITGLNGVGHTVVHQVGVKGAEETSSGDTLEISFKPGVKAGAEEIQRAVQRGSVKTVRSAPGKTAGSAVRVEHASADTAVFDGDANKLTMTGGVQVSDATSVVLADTVGMDRGTGDSTADGNVRVSYMAEDGKGEPVHVTSARAVEKHSAGTAEFFGGAGKDARMWQGGSQVEAPVLLLEDVKEAGVEKRRLTAHGDVAGEVPVVRAVLVSEKPATGAKAKSDGGAVRISGHEMVYTEGARTVVFRGRVKVEDRDGTMNAQEATAFLAEKAAGAAAAKTPGVGGFPAGRVERMVAAGAVQVEQPGRKATGEQLVYTAADQTFVMTGGKGVPPKMVDEEKGTITGATLRFRSGDKSVMISGGDASTGAQRVHGESKVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3N8</accession>
    <name>E8X3N8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1166</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579552.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68229">
        <property type="protein sequence ID" value="ADW68229"/>
        <property type="gene ID" value="AciX9_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1166"/>
    <dbReference type="eggNOG" id="ENOG50348NZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773313_0_0_0"/>
    <dbReference type="OMA" id="TTHAFRY"/>
    <dbReference type="OrthoDB" id="1976196at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="40415" checksum="0DFDDCD437AC4EDC" modified="2011-04-05" version="1">MPTPSRRQRYESLTLRIVLLLATLHLLWFYINKVISVLSLPRYEQGVERMPFQARLLMQLPLRWAHSSPTLIHAAATLTQLNTWLPRGVIPEDLVELPIYLLFTLIAGLVARSLYRTYSRTALLLPYVYPLFLIMVATSYCILTTHAFRYVYDLPSLGLFAIGLWLIQRRAHPILFAALFLIATLNRETSLFLLYFFVVSNCVAEEKFHWPRAFSLRVLATTLPLAAAWIAWHLFVTRHFAGLDSESAPRIQTNLITLAWPMVWPQLFAVLGYTLPILLIVRSRTRPLELRLWLWITPVWAVFMFFFGVFAEVRLFGELIPIFTAAAVLLAEERIILSLTQKGAGDHLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T6</accession>
    <name>E8X3T6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2327</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580680.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2327"/>
    <dbReference type="EnsemblBacteria" id="ADW69364">
        <property type="protein sequence ID" value="ADW69364"/>
        <property type="gene ID" value="AciX9_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2327"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064918_0_0_0"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233633" description="Lactamase_B domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="96"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="39333" checksum="3947E43935732C0D" modified="2011-04-05" version="1">MQLDRRNFLALPVLSFVVPAANALMNSENGLVSPAAPAFVGPVDFRQNVPAPGTFPAKWICGSESAMDNTDPPVQVHWYNEHTAVLRQNKCYSYEAPFMMLYFGNERVLMIDQGFNSLRSDWPLRDVVDDCIDTWAKKHGHKAEDLELLLAFSHLHADHYAAQNEFVDRPNTRIMGLTHEEMVGFWGMTHYPEQRVVLDLGGREIWIWGSPGHVMSEFAYYDTYTQILYTGDMFYRGRCYISFWQPWFDSMTRLIKFLDDGHPVTHIVGCHVEMGSKGEDYPYGVTWQPEEAPWQLTVAELRHAYEIAKTITKPGIYFTGGVYLCNQTRGTTTIDKNPYAYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z6</accession>
    <name>E8X3Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Formamidopyrimidine-DNA glycosylase</fullName>
            <ecNumber evidence="19">3.2.2.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">AciX9_3499</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="19"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581815.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3499"/>
    <dbReference type="EnsemblBacteria" id="ADW70504">
        <property type="protein sequence ID" value="ADW70504"/>
        <property type="gene ID" value="AciX9_3499"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3499"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_1_0"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ADW70504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="269" mass="29470" checksum="3A8B68547B838EBD" modified="2011-04-05" version="1">MPELPEVETVANGVHDRVHGQRIDSVWTSGKPQTFKSPETEIAEVLTGARIDRVRRIGKTVVADLTRSSGETAQFLVHLGMTGRLLVSHPEVPLPPHTHAVLGLSGGNELRFVDARRFGRLSVVHEAYGGPGAEPLTINEEDFIALFKGRKLAIKAALLNQSLLHGVGNIYADESLFRAKIRPRRQAGKLTRDELKRLRTALIEVLRHAIKLGGSSVSDYVDADGVRGFFQLEHKVYGRAGETCKDCGTALKKIIVGGRTTVYCPTCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X455</accession>
    <name>E8X455_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0024</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578444.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0024"/>
    <dbReference type="EnsemblBacteria" id="ADW67115">
        <property type="protein sequence ID" value="ADW67115"/>
        <property type="gene ID" value="AciX9_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0024"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_0"/>
    <dbReference type="OMA" id="TPIFMEA"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="545" mass="56955" checksum="06BD9940490B6BB3" modified="2011-04-05" version="1">MPTEVVMPQMGESITEGTLTKWLKKPGDPVERNEPLFEISTDKVDAEIPSPAAGIMGEIKTPEGSTVQINTVVCTINEAGSAAAAAPAPADLKADSATPAAEATAAQEAAIPAPEPETEVSGGTEVAMPQMGESITEGTITKWLKNIGDTVARDEPIFEISTDKVDAEIPSPVAGTLTEIRVKEGATVTVNTIVAVIGGAAGSKPKAAAPAAVAPAAPAAVAAAPTQASQGETPRSSPLVRKIAGDNNIDLQQVSGSGSAGRITKADIMGHLDKPASTAAATPTTVQPSVSAVQSAPATTAPAKAAAPTQQLGELVPMTKMRSIIAKRMVESKQTSPHVHTVFKVDMTRIVKLREREKNKYEQRNGTKLTYMPFITRAAVQALKKHPVVNAAIQGDAIFYNKNIAIGIAVALEWGLIVPVIKGCEEKNFLGVARSIVDLAERARTKKLAPDEVSGGTFTITNAGIFGEQFGTPIINQPQAAILGVGGLNKEALVLTDKDGQDTIAIRNVQRFTLGFDHRIVDGADAGKFMSDFKAYLENWAEDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X491</accession>
    <name>E8X491_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0060</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0060"/>
    <dbReference type="EnsemblBacteria" id="ADW67151">
        <property type="protein sequence ID" value="ADW67151"/>
        <property type="gene ID" value="AciX9_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0060"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_0_0_0"/>
    <dbReference type="OMA" id="TRQEYYV"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="66"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="654" mass="72992" checksum="59248D17431F1F52" modified="2011-04-05" version="1">MEAPAQLRRNRLILVALWFVFYGSFTLFTPPLLDDADSVHAEVAREMLLRHDWVTLYANGIRYLEKAPVFYWSEAVAMSLFGPTTAASRLPLAIAMLALVLISESFARRAFRTPRAGLYAGLITLSSFGMFIFSRINIPDIMVCLWLVIALYAFYLTEQPEHAGPEPSGPRSLSLGPCLLFAAACALNILTKGLIGIVFPVGIVLLYLLITRGLRGTLTRLRQLHPASSLAVFLLIAVPWHILIALANPTQGHPGGVAFLNGHWSVPLPTDGNVHGWTWFYFVNEQVLRYLNLRVPRDYDTVPLALFWGLCLIWLMPWSAFLFHAVARALPIRTAAFRQRLRTKTLTNQERTDLLLILWAAIPLLFFSLSTRQEYYVLPSLPPLILLIAAWLAQRFADSGRAKQHRASSLRSAGALALVGLCAAAVCLYLILHTKAPSQDTDLASLLQQNPGDYALSFGHFLDLNARAMGLFRLPLALTAISLGGGLTLAWYLRRPRYQTGFESTYVHAANLVIAASAFLFLFASWLGLRTFSPTLTSHQLAQAIAPQLHQQDLIVLHGEYEAGSTLGFYLHRNDLHILEGRSSNLWYGSFFPEAPKIFETRDSLAAKWPGPQRIFLWEDPHDPDRPILKLPQPIYVIANSGGKYILSNQPNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I9</accession>
    <name>E8X4I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2362</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580715.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2362"/>
    <dbReference type="EnsemblBacteria" id="ADW69399">
        <property type="protein sequence ID" value="ADW69399"/>
        <property type="gene ID" value="AciX9_2362"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2362"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_10_1_0"/>
    <dbReference type="OMA" id="CCISAYQ"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="11187" checksum="0C24CEF3CF184064" modified="2011-04-05" version="1">MSRYVLGGQVEFDMDEIWEYIAKDSLDAADRVLVTFYEAMDALTLDPGAGHTRRDLTALPILFWPVGSYLILYKKGLALIQIVAVVHAARDIPSFLKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K5</accession>
    <name>E8X4K5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ordered locus">AciX9_2378</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2378"/>
    <dbReference type="EnsemblBacteria" id="ADW69415">
        <property type="protein sequence ID" value="ADW69415"/>
        <property type="gene ID" value="AciX9_2378"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2378"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3422676_0_0_0"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="375" mass="42758" checksum="16469EA17EEADB06" modified="2011-04-05" version="1">MLSDLEYQYSPVRDKVRELREYLDSSRLRRELAIVEEKIADPTVWADAARSQPLMRDRKRLETLLADDAELARRSDDIEAYFELAKEGEDTEPDLVREIPALVEYADQLESKTMLSGETDLLNAIVTVHPGAGGTESQDWAEMLMRMYIRWGERQRFKVEINEIQDGDEAGIKSATFTISGEFAFGLLSGETGVHRLVRISPFDSAKRRHTSFASVFVSPEIDDTIVIDIKVEDLRIDTYRSGGKGGQHVNTTDSAVRITHLPTGLVTGCQNERSQHKNKERAMKMMRSKLYEYELDKKKAATRKIEDSKLEIGFGSQIRSYVLQPYRMAKDLRTRVEVGDVDKVLDGDLEPFIRGFLRMRREGNLPATLDDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V1</accession>
    <name>E8X4V1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3587</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3587"/>
    <dbReference type="EnsemblBacteria" id="ADW70590">
        <property type="protein sequence ID" value="ADW70590"/>
        <property type="gene ID" value="AciX9_3587"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3587"/>
    <dbReference type="eggNOG" id="ENOG502Z9RG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030096_0_0_0"/>
    <dbReference type="OMA" id="YPVNWWL"/>
    <dbReference type="OrthoDB" id="1709295at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="79"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24860" checksum="0B3B42FA04ABB7DF" modified="2011-04-05" version="1">MGMFELIAWISLGLAFVSAAVIVIDEVRHPQKMGVMNIVWPATALYFSVFAVWAYFVKGRGMARDAVQGMEHEEGQSPTWAQTALAGSHCGAGCVLADVVTEFVVFGVGLTLFGKELYASYLWDFVAAWLIGVAFQYFAIKPMRDLTVAGGIWAAVKADTLSILTFQIGMYGWMAVVFFKLFPGPHLHPNDAGYWLMMQIAMVCGFVTALPVNWLLVKIGWKEAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W6</accession>
    <name>E8X4W6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="13" type="ordered locus">AciX9_3602</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581916.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3602"/>
    <dbReference type="EnsemblBacteria" id="ADW70605">
        <property type="protein sequence ID" value="ADW70605"/>
        <property type="gene ID" value="AciX9_3602"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3602"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_0"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="623"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="704" mass="76210" checksum="BBC639A8DCBAB2EE" modified="2011-04-05" version="1">MSKGSVEEQVKELREQLEHHEHLYYVMDTPELTDGQYDSLMNRLKALEAEHPEMVTSDSPTQRVGGKPADGFQKVKHSRPMLSLDNAYNEEDLRAWDVRVRGGLPGTEAVAYTCELKLDGLSLALHYRGASHDGSQLERGLTRGDGTTGEDVTSNVRTIRSIPLTISAAKLKAAGLPMEFEVRGECVMPHAAFLKMNEEFEAAGLAAKANPRNAAAGTIRTLEPNIVAQRRLDFYAYFLLQAEGGEMLLGSQSEALTALGKAGMRVNPQVATVDSIDGVWEFIQRCEPLRDSLGYEIDGIVIKVDKAAQQRRLGFTGKAPRWAIAYKFAARAGVTKLEGVAFQVGRTGKVTPVAQLSPVFIGGTTVKRATLHNPDEIVRLGVRIGDFVSVERGGDVIPKITGVVLEKPRGTQEIVFPECCPACGSALVKEEGEVDWRCVNASCPARLREELIHFGARGVMNIEGLGDAMVGQLLGQVEDAVDETDIEKEEAAAPVTVREPLVRSIADLYRLTKEQLVGLERVGDKSAQALLDEIAKSKKAPLSRVLLGLGIRHVGQRTAELLASHFGAIEPLMGATQDELVQVNEIGPIVAATVHDFFAQEQNQALVKELLEIGLEMKAEKRVTTTVLEGLTFVLTGTLPTLTREIAKEKIEAAGGRVSGSVSKKTDYVVAGEDAGSKLEKAESLGVKVVDEAGLLELLEGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X3</accession>
    <name>E8X4X3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="17">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ordered locus">AciX9_0074</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 17">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="17">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="17"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578494.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0074"/>
    <dbReference type="EnsemblBacteria" id="ADW67165">
        <property type="protein sequence ID" value="ADW67165"/>
        <property type="gene ID" value="AciX9_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0074"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036876_1_0_0"/>
    <dbReference type="OMA" id="LEWWLIG"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0186">Copper</keyword>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="21">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="20">
        <location>
            <begin position="109"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="22">
        <location>
            <begin position="226"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ADW67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="347" mass="38332" checksum="9FE5FAE0152E24A3" modified="2011-04-05" version="1">MHISPVLWQFLTKWLAASALFPREASTIAPYADALYFFLIGMTIFGLILVGVLVFGFSIRYRASRSPVATQVEGSTLLEATWTIIPLAIFLVTFVWGALLYFRIYNPPANAMNIYIVGKQWMWKAEHPGGQHEINNLHVPTGRPVQLTMISQDVFHSFSIPDFRVKREVIPGRYSTVWFQATDPGTYHIFCTQYCGTKHSGMIGEVTVLTPADYQKWTEQSTSGMSLAQNGERLFASMGCNACHSGTAAARGPNLAGVYGSKLTLTNGSQVLVNDAYLRDAILNPSQHVTAGYAPIMPTYQGQISEDGLIDLVEYIKNQNSNYRNQQTLGTSQSDLAAPTTPGMVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X566</accession>
    <name>E8X566_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1268</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579653.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1268"/>
    <dbReference type="EnsemblBacteria" id="ADW68330">
        <property type="protein sequence ID" value="ADW68330"/>
        <property type="gene ID" value="AciX9_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1268"/>
    <dbReference type="eggNOG" id="COG4641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067339_0_0_0"/>
    <dbReference type="OMA" id="DTHTCRT"/>
    <dbReference type="OrthoDB" id="1121024at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="39515" checksum="DCD69875556F7D3C" modified="2011-04-05" version="1">MKILYAGSMKPVASTHTRMLALQRLGHTVIPFDTDAYEEKNPNLHRIAFRLVIGPGVNRLNRDLPRIATEEKVDLLFADKVLSLRPGTIRKLQAQSIFTLCYVIDNAFGPRKDPGWRLYKKSITLFDLHVTQRDVSVHDLTQRGARDVIKTQTAYDQAIHFPPPEPYTDAQRNRGVSFLGTPYDDRAGFLSSLHAAGLPVVISGSPNAWQRALSTDLYQQLYREGELAQKEYREAIWRSKINVSFLTKSNQDEVTQKSFEIAACGGFLLAERSEGHSARFVEGEEAVFFSGLKECIAVIQRYLPDEAARNRIAAAGMERARRSGYNYDHQVALLIERVEALKAARAKVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X581</accession>
    <name>E8X581_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ordered locus">AciX9_1283</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579668.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1283"/>
    <dbReference type="EnsemblBacteria" id="ADW68345">
        <property type="protein sequence ID" value="ADW68345"/>
        <property type="gene ID" value="AciX9_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1283"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_0"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="383" mass="41600" checksum="BFC21C71DFFE623D" modified="2011-04-05" version="1">MATANVTKVDYYELLSVSKDADGQEIKTAYRKLAMQYHPDRNPDNPEAEAKFKECSEAYSVLSDAEKRAAYDRYGHAAFSGGGGGGGNPFQGAGGGFAGQDMGDIFGDIFGEMFNMGGSGRKGSRVQRGRDLRYDMSLEFTEAAFGVEKEITIRREEVCNDCEGSGAARGKPAATCPQCKGAGQMRFQQGFFSVARTCPRCGGTGTVITDPCKTCQGRTTVEHEHRLTVKVPAGVEEGTRIRYQGEGESGKYGGPSGDLYVVLSVKKHKFFERDGDDLHCVMPISFPQAVLGTELQIETLEGAESIKVPEGTQSGKEFRLRGKGVPHLNERGKGDLIVEVRVATPTKLNKQQRELVKQLGETMVVENAPHSRGLIDKVKDIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E8</accession>
    <name>E8X5E8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2460"/>
    <dbReference type="EnsemblBacteria" id="ADW69495">
        <property type="protein sequence ID" value="ADW69495"/>
        <property type="gene ID" value="AciX9_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2460"/>
    <dbReference type="HOGENOM" id="CLU_1018482_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="273" mass="29309" checksum="44118AD54A794ED5" modified="2011-04-05" version="1">MSDLLRTLSRQLSRSQQGAGAIRPRGRSRFEPYGDGPSSFPSGLAFDEAEHAAPFAQPGPIQANVSPQPRAEQGPRMETLHVAQPEREQSPATATPIREMIREVIRSVDPLLFPVLLAREPQAAQGPAVPVAWREREAAQPIPPASISGRAPAVESQGGPQPPVVRTPVPADEPRSARTSSQPAERLSIAPLAQRSLPRFSEGDFVRSRVPAAQAFPQAAQPAGRQEITIEIGSIIVHGDASERRTPHSIAAAPPQAPALSLERYLQHRGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q9</accession>
    <name>E8X5Q9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type VI secretion ATPase, ClpV1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3997</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572705.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70793">
        <property type="protein sequence ID" value="ADW70793"/>
        <property type="gene ID" value="AciX9_3997"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3997"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="OMA" id="YGGERKM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017729">
        <property type="entry name" value="ATPase_T6SS_ClpV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03345">
        <property type="entry name" value="VI_ClpV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="439"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="886" mass="96763" checksum="DEF0F832C118FBD0" modified="2011-04-05" version="1">MSLNLKSLIAKLNDTTRSVLEASAGLCMSRTHYDIEIEHYLVKAMESSDNDIASILKHYGVDKSRLSKELDRALDNIKTGNARSPAFSPQLVKMLAEAWTVASIEYDAGSVRTGFTLLALLTHEDLARAVKEISRELQKIEPEGLRKDFYTIVANSREVQASLKPTGGTGDATTSDGPAAGKGKTPNLDQYCVNLTGNAKAGKIDPVLGRDAEVRQMIDILMRRRQNNPILTGEAGVGKTAVVEGLANRIVQGDVPPALQGVHLYSLDLALLQAGASVKGEFEQRLKGLINEVKSSTEKIILFIDEAHTMIGAGGTAGQNDAANLLKPALARGELRTIAATTWSEYKKYFEKDPALARRFQVVKVEEPSEEVCCTMLRGIVASLEKHHGLRILDEAIVATVKLSHRYIAGRQLPDKAVSVLDTACARLALGQNSMPPQLEDVLRTIDSLEVQKRVLERENVIGASHGERVTEIDEKIAKNKATLEELKERWEKEKALVSGIRTIQIELEAEPKKDEAAAAEARKKLGELEAELLALQGETGLMSVSVDAQICGAVISAWTGIPLGKMMKDEISTVLTLAEHLKKRVIGQDHALAAIAQRILTSKANMDDPVKPIGVFMLVGPSGVGKTETAIALADLLYGGEKNMITINMSEFQEAHTVSTLKGSPPGYVGYGEGGVLTEAVRRRPYSVVLLDECEKAHPDVLELFFQVFDKGRMEDGEGREIDFRNTIILLTSNAATDTLMKLCADPETMPFSDGLLAAIKPELNKIFKPAFLGRMITVPYFPVRDEALKQIIRLKLGKIQKRLRETHKVTMTYDDALLNEVASRCTEVESGARNVDNILSNTMLPEISRQMLGKLAEGETIESVAISVADGKMTYDWQEVAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T4</accession>
    <name>E8X5T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4022</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572730.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70818">
        <property type="protein sequence ID" value="ADW70818"/>
        <property type="gene ID" value="AciX9_4022"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4022"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NGFMVNG"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230756" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="141"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128389" checksum="151D3D17DC4C7209" modified="2011-04-05" version="1">MNDRLSSAKRQILLASILIGSGSSLHAATGGSVSGTVTDASGAVIPGAALTLVSVGQQTVYKTVANGQGLYSFPNLPVGHYELTISADGFTPQRKSNLTVDTDSVVRVDTELAVGNRSDSVTVTSETGIQVETSATHLGEVVTGDQMAALPLNGRSYTDLLSIQPGVAPVSTLLPNAVIMAGVTGGISPSGDENPGNVSINGQRESSNGFMVNGVDVQEHMNGGTSVVPDLDSIEQFRVLTNNFDPEYGNYNGGVVTVVTKSGGGRLHGGAFEFFRNTALDARGYFDPTRPEFKQNQFGGTLGGPVGHTKLFFFADYQGTRETQGISTGNISVPTVAERTGNFSADAAEFTTKAVVSGTSIDVPTVVSGPYLATQVLAPKLGYSVASGEPYTYRAGESMPVDANNLNAMPARYGSDCVSTTQCVFPNLSIPQSAWGAPGKSLLGFIPTPNAGDGLFSTSASTQTNRDDKGSFRLDADTRAGRISAYYFLDDYTLDNPYPGSQGGASIPGFDALTIGRAQLLSVSDTKVIGANSVNEFNLGYLRYANVVGKPQGGLGVSLASQGFTTGAGTPGIYVQAPEFEGVENVTFPSFTMGVPITNLTQVNNTYYVSDGFSRVFGAHTVKVGAQFHEEQVNEHPNATFNGTFNINGTETGSAYADLLLGTPSNYTQSSGQPFYLRNHYLGVYAQDSWRVRNDLTLNLGIRWDVVEPWSEKNHQLQTYIAGRQSVLYPGAPAGFVVAGDPGVPETIAPTSFKNFAPRIGVAYAPRFESGLGRLLFGESGKSSIRASYGIFYTAFPGLSAGIMYAVPPFGFNYLSPGPPLLATPFITAATGVNNGQRFPFPFPPHNVSTSNPDNNVDWSNFTPIAADPFFNSRNRVPYINNYMLSLQRQITRDLVFTASYVGNQGHHLLTLVSVNPGDPALCLSLPGCGAFGEDTAYTNGAGQTVRGTRVGQGSNYGENTSDSSIANSNYNALQTTLKYQHRGSSFLLSYTYGKSIDQGSNLGEQLDPVDARHSRAISAYDLRHDFVATYDLQLGVDQLVGRSNRWTKDWSLSGTTRFASGLPVTLSDNSDNSYLGTLGNGANNFLIDTPQYAPGNLQINKDGRSGRDAFRVASFQEELPGQLGNAKRRFFYGPGIDNYDASLQKGVRLRDAMTLNLRLEGFNVFNHAQFFGPAAVNGQFEDPLFGKIVSATAPRLVQVAAKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V7</accession>
    <name>E8X5V7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4047</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70841">
        <property type="protein sequence ID" value="ADW70841"/>
        <property type="gene ID" value="AciX9_4047"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4047"/>
    <dbReference type="HOGENOM" id="CLU_422602_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230264" evidence="2">
        <location>
            <begin position="27"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="30"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="516"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="648" mass="68497" checksum="8DEA7E87F787BCF3" modified="2011-04-05" version="1">MSDVHRLRYFRSVLSLSLGCCLLVRAGAQQTSGWKLVWSDEFNGAAGAPPDAANWKFQTGPGAAIAGNEEAEMYCARDSSAPCRADQPNAYLDGKGHLILVAIRTDATVTVGAKKASSPVYTSARMVSVPSFLYGRLEASIRIPAAGKGIWPAFWALGQEVGGVHWPAVGEIDVMEQWNPLPGTPEKIDGVTIHGAVHGPLAPGSKTGFLDQSADYIFPANPAAGLHQFAVDWTPGAVDFYVDGYLYHRTSVGSLTGKEQWEQDRGPFSLLLNLAMGGGFFGYPDASTGATPTMVVDYVRVYQRQEKALATGWSNADIGGPAEAGSAVLRDGVYTVAGGGAGISGRFDQFQFAYKPMAADGEVTAHVIDQSSKVAQAKAGVMLREGRGAASPYAMAFVSPDGSVHFRFRTARGEVPGEVLYKGPATWLKVGRLGDVFTGYASTDGKKWDAIGNAKLALKHDLIAGLIATSRDNKADNSVRFDYVDVTRTDAAFDGEAAPLPGVVQAERFDAGGAGYTYSAEFGDGGPRIEEMADAAGTENSARGYSLKELKAGRYINYSVEVAKDGDYVINVRTASAGAGGTLHFNLDQKPLSKPFSLPATGGNDTWQEVKSPIVHLSAGRHTLALVTDSAGASGVMANIDLFSVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W5</accession>
    <name>E8X5W5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4060</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572761.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70849">
        <property type="protein sequence ID" value="ADW70849"/>
        <property type="gene ID" value="AciX9_4060"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4060"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="ADPFYGP"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="38133" checksum="696CDECBAE46257C" modified="2011-04-05" version="1">MAVRLKDIAHDLGVSTVTVSKVARGSLDVSDATRKRVLKRMAELNYRPNLVARGLASGRTYTMGLVVPDLVHPYFAEFAKALSGILRTNSRALVITSSEEDPEVEHEEIRNLLSRGVDVLMIASCQTNLRNFFELGVNRTPYLLFDRNFPNLIANFVGSDDVAIGEMATRHLLELGRRRIAHIGARNSSPSFDRLRGYQNVLVEAGLSTSDRLVIQRERVEETGDAMGAQMMKLLLKLKPRPDAVFCYNDLTAIGAIEAILEAGLSVPEDIAIIGCGNLRYANYLRVPLSSIDQGASELGRLAGGLALELSAMPDQEAQSIRVPPRLVARASTLGKVSPKKKELSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X601</accession>
    <name>E8X601_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572797.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70885">
        <property type="protein sequence ID" value="ADW70885"/>
        <property type="gene ID" value="AciX9_4105"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4105"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="FLANYTW"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230269" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1152" mass="122479" checksum="A6DE2F856588C9E2" modified="2011-04-05" version="1">MTARIWNSLWTAKGRFVVLFLLALSLTAVASNAQTAGTGNIQGNVVDATGAIVQGAAVTATNTATQTKHTAVTEGNGSYSFPNLDVGTYTVEVGAKGFQGYKQSNIALEVGSSIAVNVSLTIGTESQTIEVQATGIALQTEDSSFKQTIDQKTVTELPLNGRLMTQLITLSGGSVNANENNDQQGSKTFATSAVVSVAGGQGNQTDYRLDGGDHNDYMTNINLPFPFPDAVSQFSVETTALGAQSGLHPGGLVNVVTRSGSNQWHGTAFEFLRNNYLNATNFFSTCKIVAPATTCSAKDTLHQNQFGGTIGGKIMRDKLFFFGGYQRTNQSSTQASTTAFVPTAANLAGDFSVTDGPNCQKTGLQLLNPQTGAVLANNQISPTAFNPQALALLKYLPATSDPCGKVTYAIPLQVQENQFISRVDATINARNSLYGRYLLDGYTSPAYFSPTNVLLTTQPGNIERAQGLTIGETFVINSNLVNAFHATATRRRDNRGPAATGISPTTLGVNVYVPVDPGLLLTVTNKFSTYCGTCAVAHFNDNTFSFSDDVNWLIGKHQIAFGGEFVRSQLNISNIYESDGKFTFSGTYSQKGPAGKSAGGTGADANLDFLTGSMSGYEQSKAQQNALRGSIPSLYVQDVYHPTKRLVLSAGVRWDPEFFPADYFGRGSEFSMAGLLAGTISSVYPNAPAGSSFYGDPGVPKAFTKNSPYQFSPRVGVTFDPTGGGKTVFRAGAALVYDEPNFFTGQRTNQNPPFAQTIANTPVNVPLSLTNPWSNGTQTTNPFPQPFKPTAATVFPNGGQYIVLTPQFHSPYSIQYTASMQQEFGKGWEFQIDYIGNRTDFLPYGYPLDAAVYIPGTCNGTPCSSLGNTASRYALTLANATQGPKYSGGGGGSILIKPGANASYNGMVTTIQHRLSSTFVFLANYTWSHCIDISDNTADVAGTSVQNPSNIKGDRANCGFDYRDVFNTTIVASSHFALTGWKAQLINNWEISPLVHITDGAPFTVTAGQDNSLTAVNNDRANLINPNTVFTHTKVVAPGTSGAAFTQFVNPSAFSANATGTFGNSGRFAFRGPDFLQVDSSLSRIFPIHDRLALDLRFEAFNVLNHPNFAGPGSTGFAGSSSSILSSTFGQITSTVNNYGARIFQAAAKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X631</accession>
    <name>E8X631_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Export protein FliQ family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4135</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572827.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70915">
        <property type="protein sequence ID" value="ADW70915"/>
        <property type="gene ID" value="AciX9_4135"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4135"/>
    <dbReference type="HOGENOM" id="CLU_164516_2_1_0"/>
    <dbReference type="OMA" id="TMPWMLN"/>
    <dbReference type="OrthoDB" id="1939288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9867" checksum="16063DBA036D72FE" modified="2011-04-05" version="1">MGADAVVAMGRMMLEEVIILTAPILLVAIAVSLVVNIIQVLTSLQDQTLSTVPRLLATGATLFILMPWMWRHISTYTLLLFSDFHKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A6</accession>
    <name>E8X6A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4212</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572902.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70990">
        <property type="protein sequence ID" value="ADW70990"/>
        <property type="gene ID" value="AciX9_4212"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4212"/>
    <dbReference type="HOGENOM" id="CLU_006501_3_0_0"/>
    <dbReference type="OMA" id="PMWAMEY"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233734" evidence="4">
        <location>
            <begin position="25"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="216"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="7">
        <location>
            <begin position="731"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110663" checksum="07BF46293F21562F" modified="2011-04-05" version="1">MGRTVLLKFVLAVLLVFGSGLSPAQAPHRSRFNFNPGWLVQTGDPANAQAPGFDDSAWKPVTLPYAWNEDSAFKVSIDKLPTGIAWYRKHFRVPAGAPGQRVHLEFEGIRMAGVVYLNGKLLGRHEDGVSAFGFDITDALKPAAEDNILAVRTDNDFKYKEIATGTAFHWNDTNFYANYGGISKNVWLHVTGPVHQTLPLFSSLGTTGTYIWAGDFDLATNSAKITAETQVRNDSMTPQTIGYTARIEDANHLLVGTMKGSDVTLAPGEMQVVSASQPVAHLHLWSWGYGYLYKVTTTISIDGKPIDAVTTTTGFRQTAFDHGELTLNGRVMQIHGYAQRTTNEWPAIGIDLPPWLSDFSNRLMVEGNANLVRWMHVTPSRQDTDSADRVGLIQSMPAGDSEGDSKGRQWEQRVELMRDSIIYNRNNPSILFYESGNKSISDEHMAEMKAVRDRYDPHGGRAIGSREMLASHVAEYGGEMLYVDKSASKPLWAHEYSRDEAARAFWDNESAPFHKDSPLYNRNQDSHAIEDVLRWDDYYRARPGTGDRVSAGGVKIIFADSNTHHRGDNNYRRSGAVDAMRLPKDGFYAGQVMWNGWVDPERPAMHILGHWSYPAGTTKTVYVVAAKVARVQLTLNGKTVGSVTASDTDPNPARALPLGTAALPDMPHEAGVPAGQSSDFLFAFPNIAFATGKLEAIGYDAAGKRITDTHLQTAGEPASIRLFAHAGPGGLHADGSDLALVDVEVMDSLGRRCPTANNMISFAIDGPAEWRGGIAQPAAGTDIPSFSNYILSRTLPVEDGINRVLIRTQPTAGKITVTATSPGLRSAMITLLAVPVKVDNGLATYDPAAALPSNLLRGPTPTGSSVHITRTSIPIVSATAGSNPDTAARAYDDNETTSWSNDGQLSTAWIDLTLKQASTPTQIDLKLNAFRTRRYPIRITLDGTPIYEGITPMNLGYTTIPLKPAQGTHLRIALTGAPIDDKPASATIEVNGKYDGAGVAPVTHDSKAILNVIEADVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C9</accession>
    <name>E8X6C9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S9B dipeptidylpeptidase IV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4237</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="acism-e8x6c9">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71013">
        <property type="protein sequence ID" value="ADW71013"/>
        <property type="gene ID" value="AciX9_4237"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4237"/>
    <dbReference type="HOGENOM" id="CLU_006105_3_1_0"/>
    <dbReference type="OMA" id="FHPEFYK"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="269"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="657"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="868" mass="94823" checksum="FEA9B31678257AFD" modified="2011-04-05" version="1">MCTSFKGSKPIFLAMFAMWASIPTPGLSGQGTLADYQRGHELQAKAKGLVVNTPGPTNWIGETDHFWYTRAVKGGTEFVLVDADAGTKKAAFDQERLAGAISKATNHPYTALMLPFAPMTGRGGAARPMPGAAMSAPLTFVDGEKAIQFGVSGSLYKCGLADYLCAKTGPVPEEDGRGGRGASPEDEALISPEGPGGDPVDGLEYQPPASQANDAGHYDRVQHACAEVPQGGAGRGRGQVRGGAGGARLGVGSQFLGQLPAEAPETCASFDGKWVAYIENFNVFLKPVGGKEDGVPLSFDGSEGNYYSLRTLAWSPDSKKLVAYHTRPGYDREITYIESSPKDQIQPKHTTIHYAKPGDTLDIAYPALFDVATKKETEIDHGLFPNPYSISAPVWWKDGRGFTFEYNQRGHQAYTVIEVNAQTAQTRPLIAEETKTFFYYSNLGPGLSAGRKYRYDVNDGKEIIWASERDGWEHLYLYDGVTGKVKNQITKGDWLVREVEHVDEAKGQIWFYAGGIVPGQDPYFTQLYRINFDGKGLTKMTDADGTHTVSFSHDRKFYTDTWQRIDLASVAQLRKADDQKVVMDLDKGDTSALTAAGFKFPEVFVAKARDGKTDIWGTITRPMNFDPAKKYPVIENIYAGPQGSFVPKTFSAVAPDQAMAELGFIVVHVDGMGTSNRSKAFHDVAFKNLGDAGFPDRILWHQAAAAKYPYYDISRVGIFGTSAGGQSSLGGVLFHPEFYKVVVTNSGCHDNRMDKMWWNEQWMGWPLGPQYAASSNVDNAYRLQGRALIVIGEMDSNVDPASSLQVVNALVKAHKHFDMIYIPGQNHGVASLGTEHYRDDYFVHYLLGVEPPDWNKVSLPADDAAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G4</accession>
    <name>E8X6G4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4277</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71048">
        <property type="protein sequence ID" value="ADW71048"/>
        <property type="gene ID" value="AciX9_4277"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4277"/>
    <dbReference type="HOGENOM" id="CLU_2058057_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="13506" checksum="2D4DCD2DD25E0F07" modified="2011-04-05" version="1">MTSSHAARTPRVTGYDSDPLTQHVRLVGSEIIGWPYNWAVCHSGWWINHENHYVRVAGEKRHHRCPVRWVKNGGKTGYVPLHPKDIAGKPPINLKHGLYETKGWKNGSVTRVGYNSQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G5</accession>
    <name>E8X6G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4278</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71049">
        <property type="protein sequence ID" value="ADW71049"/>
        <property type="gene ID" value="AciX9_4278"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4278"/>
    <dbReference type="HOGENOM" id="CLU_1413393_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="20811" checksum="2FEE18D8328B03F7" modified="2011-04-05" version="1">MRLDSYVDGIVVTPVDAITLGSSTGGSKHLAAGQVFVLHSGRMADFQPPIDAAASQAWDTWVAQRYAERTALIDKEMHEAGLTQPVPGLAEMEGGGTFFPCASYGTCWEPAMGWNPQTKPVAPTQPVVSAQSSRSEGSHFQTTSFEACSSHELSAFAQIESQAAFSGYDDPLPFEDEDDFFPCSPYTTRYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q3</accession>
    <name>E8X6Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
            <ecNumber evidence="6">5.99.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3927</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.99.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582221.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71203">
        <property type="protein sequence ID" value="ADW71203"/>
        <property type="gene ID" value="AciX9_3927"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3927"/>
    <dbReference type="HOGENOM" id="CLU_046978_1_1_0"/>
    <dbReference type="OMA" id="QYRYHPR"/>
    <dbReference type="OrthoDB" id="812517at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisom_I" evidence="5">
        <location>
            <begin position="108"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="42400" checksum="7128548EE65EA8C2" modified="2011-04-05" version="1">MSTVSRRSKRVAADVGVSDPMASAEAAGLRYVTDAEPGIHRRKTAGGFRYVDAAGKAVRDAKMLGRIKSLVIPPAWSDVWISARADGHLQATGRDVRGRKQSRYHPHWRTVRDETKYERMIQFAGALPGIRKRVEHDLALPGLPREKVLATIISLMEATLIRVGNAEYARENKSYGLTTMRNKHVEVDGSKITFSFQGKSRVHHTIDLQDRRLASIVRRCEELPGYRLFQYVDREGNHHAIDSADVNEYLHAITGEHFTAKDFRTWAGSVLAAEMLRGFEPFSSESEAKKNVVQAIAAVAGRLGNTPSVCRKCYVHPAVLESYLGSAISAEGAKRKLERQITEHVRALRTEERTLLELLRERAVVESVASSPSAVGHTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R0</accession>
    <name>E8X6R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicupin, oxalate decarboxylase family</fullName>
            <ecNumber evidence="5">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3934</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582228.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71210">
        <property type="protein sequence ID" value="ADW71210"/>
        <property type="gene ID" value="AciX9_3934"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3934"/>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_0"/>
    <dbReference type="OMA" id="HARTFNY"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="87"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="266"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="46333" checksum="CEEEE43A9907D3D9" modified="2011-04-05" version="1">MNITKDQETGIDTSRRNFLGRGSVALATVALAAVAQGQERAQVHKAEGDHSASNPGQENKTLLEQNPNSNTPPDTDHGDVGPIWYSFDLAHKRVQEGGWTHQVTARELPSSKDIAGVNMRLTAGSFRELHWHTADEWAYMLTGKARVTVLNPDGTIFIDDVEEGDLWFFPAGFPHSIQGLGPDGCEFLLVFDEGMFSEDGTFLLSEWIAHTPDEVLAKNLGLDPSELAKLPKDELYIFPSELPGSLAADRAEVGGARVQAPQQYTFKLKAMAPTKKTAGGEVRVVDSHNFAVSKSIAAGLVTVKPGGLREMHWHPNASEWQFYIAGKARMTVFMPTSRARTMDFNANDVGYVPPVAGHYIENTGDTDLVFLEIFKADEFQDVSLNNWIRRLPTQMVREHLNLDAASIRKIPAEKQEVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X702</accession>
    <name>E8X702_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3825</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582133.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71111">
        <property type="protein sequence ID" value="ADW71111"/>
        <property type="gene ID" value="AciX9_3825"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3825"/>
    <dbReference type="HOGENOM" id="CLU_302642_0_0_0"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230303" evidence="2">
        <location>
            <begin position="29"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="959"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="672"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="730"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="985" mass="101449" checksum="7623F08DC458CD11" modified="2011-04-05" version="1">MQKPAHVKLLQVLVAALSSLAVFQPALAQTASADTIQALKLVAPRSGWLLADNRLFWTDSLGAEWSEITLTQPNAPLVSGAFFSQQGEGWTVESAADGTALTIAHTPDKGAHWSYSSIASPFTEASVFNGISHPFFADSRNGWISLSIQSSSAFRRGLLLHTTDGGLHWTPTPNPPVGADLLFTDTTHGWTGPGPNGDELFATADAGQTWHASNLPKPSAALAHTNSTITLPIFTDAAHGSLLRTYLGDTGTTVIRYDTTDAGATWQPTVLPASTTFATLAPLSQSLPTIALSKQTGLTSTPATLTPLHSSFSTEANGWVLFSAGTCIPQTGVCTQSRSLMATQDGGHTFLSLGRIPGLELESTQQTNVPKKISSSAAAPTPASSFPVTGVLGFDACTLPTVAQLQTWWTGSPYKTVGTYIGGNEFACASGLSNLTPAYVSSVLTQGWEIVPIWVGPQAPGGTFTYSISTTPATATAQGVAEADSAVAQMISLGMNQGSTIAYDMEAYSYTVAANVATTQAFIQGWDSELHAKGYLAAVYSGHNEFDTWTATTVTPAIDTIWFTYFFSSGVTCGTTCNTVYPTTIDLPANYWLNHHRSRQTSSSFNSTYGGLTLNIDEDYTDAAFEVATNVVLTAKKTGAGCGTIATATINNSLDTSIDTAISCGTGCTSATASFAPTDTVTLTATPATNSVFASWSGCTSVSGTTCTVATTAAITVTATFNAAPTFALTVAKAGTGTGTVKSSDNFISCGTTCSASYIAGTSVTLTVTPGTGSLFGNWAGCTSTSGTTCSVTTGTAASTVTATFNPAPTFAAALSTTTLAIVGGQSATDTLTISPQVGYTGTFSPLACSGLPTSATCTFSPTTLTAAGDGAKLTSTLTITTIPVFTASIAEPTKLVMAGLLFPALFLPFCFIRQSAQKLRRFILLSICVLALGASQFLTGCTPGNPAPYSTVPPGVPFSGTINVTITSATGVTSLPIALTITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X739</accession>
    <name>E8X739_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71273">
        <property type="protein sequence ID" value="ADW71273"/>
        <property type="gene ID" value="AciX9_4317"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4317"/>
    <dbReference type="HOGENOM" id="CLU_027402_31_0_0"/>
    <dbReference type="OMA" id="PLRDECL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="103"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="34665" checksum="99F424616D6CB6C0" modified="2011-04-05" version="1">MGHARQSHGLSERHACLVVKQPRGTQRYRPTQRDDEDRLTHAIVTLAARYGRYGYRRITALLQRTGWSVGKDRVERIWRREGLKVPKKQKPRGRLWLNDGSCVRLRPQHANHVWSYDFVSAKTHDGRTVRMLNLIDEHTRESLLVRPERRWSSAKVIEALADVMVIKGVPEHIRSDNGPEFVAHDLRKWLAGTGAKTLYIEPGSPWENGYCESFNSKLRDEFLNGEIFYSLKEVQVLAERWRIHYNTIRPHSSLGYRSPAPETWPHEIKTGYGEVESRVRLPLPHTLDGGEISTKLAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X765</accession>
    <name>E8X765_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4347</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573018.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71299">
        <property type="protein sequence ID" value="ADW71299"/>
        <property type="gene ID" value="AciX9_4347"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4347"/>
    <dbReference type="HOGENOM" id="CLU_117621_7_0_0"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7670" checksum="166CC09F3D7F699E" modified="2011-04-05" version="1">MYKGTVKWFNNAKGYGFLGREGDPDVFVHYSPIQIDGYKSLEEGDAVTFDIIQGETGRPQADRVSRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X790</accession>
    <name>E8X790_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4372</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573043.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71324">
        <property type="protein sequence ID" value="ADW71324"/>
        <property type="gene ID" value="AciX9_4372"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4372"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_0"/>
    <dbReference type="OMA" id="GQAAWMY"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="43243" checksum="19F0032887688185" modified="2011-04-05" version="1">MTPIEPFSPTFSSDHWEDLRSRIKQTRWPDEIPGSDWGSGFELQSLKDLCRYWSEDFDWQKQIDRLSQFPHFRFKSDQGKIHFLHVKGRGPAAIPLILTHGWPGSFLEMLEIVPLLTNPVAHGLAADISFDVVIPSLPGFGFSDRPQSEGVNSFRVAEIWVELMRALGYDRFAAQGGDIGAGVSTALGLRHSEHLIGVHLNYIPGSYKPYLAPGTEITPAERQFQAEAAQWYDENGAYAHMQGTRPQTPAYALNDSPAGLAAWMLEKFREWSDCGGDLYSSFSRDALLANVTLYWMTQTISSSFHMYREGRRSPLHFSSTDYVPTPCAIACFPKEIMMPPRSWVERGYNVTRWTPMPKGGHFAAAEEPELLASDLQAFFGTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X793</accession>
    <name>E8X793_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573046.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71327">
        <property type="protein sequence ID" value="ADW71327"/>
        <property type="gene ID" value="AciX9_4375"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4375"/>
    <dbReference type="HOGENOM" id="CLU_079574_0_0_0"/>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="31124" checksum="F5E4AB8A211996DF" modified="2011-04-05" version="1">MRTTKAPRRAEAFIVTKEHRRFMEFANVVRKERYIGLCYGAAGVGKTQSARRYAHWQSVEPLLTRWGPRDEADKKIYATLARSRVLFFTPDVRANFGALRHQIDDLLGRINVCIDQHTGKTARTLPWDYVELVVLDEAERLNTAALEYLRDLFDRNDIGLILIGMPGIEKRMSRYPQLYSRVGFAHHYRPLLGDELSFVLARHWQKLGLQLDGADFTDAQAIASIARITGGNFRLLRRLFLQIERVLRVNDLTVITDDVVNAARSTLVIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F9</accession>
    <name>E8X7F9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4447</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71393">
        <property type="protein sequence ID" value="ADW71393"/>
        <property type="gene ID" value="AciX9_4447"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4447"/>
    <dbReference type="HOGENOM" id="CLU_1061446_0_0_0"/>
    <dbReference type="OrthoDB" id="1557327at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="28062" checksum="A0DB80C4A7078D60" modified="2011-04-05" version="1">MQTQRAYRTKLALGVIVFACVATPSFALFGIGDIVFDPTSYASLVSQLSTLQMQYNTVKNNLVHFSAKNQWHTALTALEHVNVANQFGETALFSVALNTNDPGSAKVAWGNATVPVNSSASVYLSSQPTNSAGKSQLAMIEASDASSPDCLNAVGAYRAARDTNLSSEQALQDDQLDEGDDTNAEVQQLNLLNAAQAQHLVELKAQGVLHACLAQQMAIQNMQQRNAAANDLNTWGFVQQQRQANNVNLTGGSQIWTTYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I9</accession>
    <name>E8X7I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase, LytS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4477</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573142.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71423">
        <property type="protein sequence ID" value="ADW71423"/>
        <property type="gene ID" value="AciX9_4477"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4477"/>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_0"/>
    <dbReference type="OMA" id="WFTDELL"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="363" mass="40961" checksum="B32A372D350BB38A" modified="2011-04-05" version="1">MMKTSLKWSVVSVVFWTLVAAIFALPQLERSRDLHRIFLSAVAQWWSWGILVPGIVAVDRALPFAVQRIAPRFITLFALSPFVSILYGYVHAVLKAALGAGKWSGLTGTAVVSEAYMEMFWSMLVYCLIVGVWEAYRYHERFVSAELQMERLQRNFSEARLNSLRMQLDPHFLFNALNTVSSQVEREPKLARKMIEHLGDLLRLSLDSQGVQEISLAEELAFLDHYLAIQKIRFGDALKVEMQIAPEVKDALVPSLFIQPLVENAIRHGISKRARGGVILLSARRFEEALMIQVLDDGVGLPAGWSFDTHKGVGLSVTRERFAGLYPDDASHFDVRRRSEGGTEVSMSFPLHKREETDDSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L4</accession>
    <name>E8X7L4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573167.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71448">
        <property type="protein sequence ID" value="ADW71448"/>
        <property type="gene ID" value="AciX9_4504"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4504"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_29_4_0"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9463" checksum="B2BE0766BD88BA64" modified="2011-04-05" version="1">MYYSADICHFLGMAKDVCVTLGERIYALITERGWSQKKLAELAGIHADYVHDVEYGKKEICLRMLARISAALGCKMSDMLEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N5</accession>
    <name>E8X7N5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prevent-host-death family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4531</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573188.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4531"/>
    <dbReference type="EnsemblBacteria" id="ADW71469">
        <property type="protein sequence ID" value="ADW71469"/>
        <property type="gene ID" value="AciX9_4531"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4531"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166832_1_0_0"/>
    <dbReference type="OMA" id="REFNRDV"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9524" checksum="763209704E9AF2ED" modified="2011-04-05" version="1">MSITTVSSRDFARDLAQAKRATTAGPVFVTDRGKPTFALLKIEDYYKLAGEKPRSLLDIMDSLPGGQFEFDPPKLDNMGFKPAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P6</accession>
    <name>E8X7P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4544</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71480">
        <property type="protein sequence ID" value="ADW71480"/>
        <property type="gene ID" value="AciX9_4544"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4544"/>
    <dbReference type="HOGENOM" id="CLU_3062062_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="5667" checksum="E0C2E5F115517CB4" modified="2011-04-05" version="1">MMRKIILWTTVLSGAAAAYLLFKRGVPVGTIASDVLTHPIGTLIHELGNSGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S8</accession>
    <name>E8X7S8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4582</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573231.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4582"/>
    <dbReference type="EnsemblBacteria" id="ADW71512">
        <property type="protein sequence ID" value="ADW71512"/>
        <property type="gene ID" value="AciX9_4582"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4582"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_3_2_0"/>
    <dbReference type="OMA" id="DVKFFYN"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234282" evidence="2">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="215" mass="23778" checksum="708750DA5B4C5AA2" modified="2011-04-05" version="1">MRIATFFAVAGLLLSSVMHADDKLHEHSQYHLHPGDTLSLDYRLSPELNQTATIGPDGFVDLSLAGTLKLSGLTLQQAHDLIVERDSARLNAPELNLQLKDFQHPYVMVAGQVLIPGKIEMREDMTALQAVMLAGGFKDSARETKVVVFRRISGNSGMAEVLQLNLHRIHKTKQLEQDLSLEPGDIIYIPENMATQFSKFMRIPNFSASAGVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U3</accession>
    <name>E8X7U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9, prolyl oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4597</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573246.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71527">
        <property type="protein sequence ID" value="ADW71527"/>
        <property type="gene ID" value="AciX9_4597"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4597"/>
    <dbReference type="HOGENOM" id="CLU_008615_3_1_0"/>
    <dbReference type="OMA" id="HARDYWG"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="397"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="611" mass="67553" checksum="4ED707D536EC2B03" modified="2011-04-05" version="1">MTSDALSPLIPRSAIFADPEMAYAQLSPNGNMLAYLAPVEGKVGVWVRTIGQENDRVVARDALRPIPWAQWQGDGQHVLYLQDSRGDENYHLFRVGLLGHEPMDLTPVPGARALPLAIDFRYPDEGLITMNARTPSLMDVHRVNFATGSNLLDIENPGDVQLWLADNMLQVRAAVAQIAGGNFAIRVRDVAGSEWRVLDEIAFADGRPRLVAFSPDNRFLYAITAKNANADRLVQYELSSGAVATRFEDPAYDVVKVYIEPDTREIGAAAVLRDRLVWTPLSDSWALSLKSFEALDAGEFSIASGTKNGDPLILQCQSDTSPEKYFLYSRETCHATLLFHCRPNLLIYTLAAMKPITFSAGDGLRLSGYLTLPVGLEPQGLPTVLYVHGGPWHRDRWGFDPVVQWLANRGYAVLQVNFRGSTGYGKAFLNAGNREWAGAMRTDLLDARDWAIKAGYADPARCAIFGMSYGGYATLTALAWTPDAFRCGIDVVGPSDLTTFLASIPPYWEPMRKLLEERVGDEDAFLKSQSPLYRVSSISAPLLIAQGANDPRVKKRESDQIVQALRENGREVEYLIYENEGHGLAHQENLQHFAEVAESFLARHLGGRAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X807</accession>
    <name>E8X807_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71591">
        <property type="protein sequence ID" value="ADW71591"/>
        <property type="gene ID" value="AciX9_4661"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4661"/>
    <dbReference type="HOGENOM" id="CLU_2081500_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="13550" checksum="D5E84797A97CEE1B" modified="2011-04-05" version="1">MIRTFQWRLTITNAWVEVDNGFRSHFIPFTEISGRRSAAGRGTSGIYLYRRGDSRVYVNESMFRLDDYYQQWQASIYDLDKADRLERKACGKETPTDWFATDNEKQNPAIGGPEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE2</accession>
    <name>E8WVE2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1328</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579713.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1328"/>
    <dbReference type="EnsemblBacteria" id="ADW68390">
        <property type="protein sequence ID" value="ADW68390"/>
        <property type="gene ID" value="AciX9_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1328"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="NAAHAHR"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="26134" checksum="EE29F602CA217046" modified="2011-04-05" version="1">MSQFAASSQQTSKLLAGKSVLVTGAAKRIGRAIALTLAQAGADVAITYRASAAEADETVAELAGLGVKATTWQCDLNNPEDIKDAVTSVIAAHGRLDLLVNNAGTFASAALESITPGEWDAMFAANTRGPFLMAQAAFPHLRESQGRIINIGSLGGLEPWSTHAHYCTSKAALHMLSQTMAKAWAPEISVNCIAPGMIVQGEVGAAYQHFADRTPMKRNGTSADVAAAALFFATGPHFITGQLLAVDGGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE6</accession>
    <name>E8WVE6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1333</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579717.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1333"/>
    <dbReference type="EnsemblBacteria" id="ADW68394">
        <property type="protein sequence ID" value="ADW68394"/>
        <property type="gene ID" value="AciX9_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1333"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_3_0"/>
    <dbReference type="OMA" id="HYSTIKM"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7250" checksum="7CA384E4233057F2" modified="2011-04-05" version="1">MEQGTVKWFNDAKGFGFISRQNGEDVFAHYSAITSSGFKSLQEGQAVQFNVVKGPKGWQAADIQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG4</accession>
    <name>E8WVG4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1352</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579735.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1352"/>
    <dbReference type="EnsemblBacteria" id="ADW68412">
        <property type="protein sequence ID" value="ADW68412"/>
        <property type="gene ID" value="AciX9_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1352"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_1_0"/>
    <dbReference type="OMA" id="QANDQYI"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233901" evidence="3">
        <location>
            <begin position="37"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="53832" checksum="2A5A9EEDAD91EB5F" modified="2011-04-05" version="1">MTKTKAVSRPRLAQLALAACLVGGPVVLAPTGSAFAQAPGGSQPGASSTGTSSGANASAIQSGQTQLYNATGQNGATPTQDSYKGSIVTGKSTGTMMDLTLDDAIQRGLRQNLGIILQSSSVQGANGQRLEQLQQLLPTVTGSASIEVEQVNLAAYGLKFPGVNPIIGPFQVVDFRAYLTQNVLNIAALQSYIASKHNFAGAKLTAEDARDMVVLTVGNAYLLCIADAARIEAVNAELKTSKVTLDQAVAGHDAGTNPRLDVLRAQVDYQNEQQSLISTANTLAKDKLALARAIGLPLDQPFQLTDTAPFKPLDNLNAETAFTEALKSRKDLQASQEAVKSGEAQRKAAIADQFPVVSVSGDFGDIGETAGHSHGTFTATGQVSAPILQLAKTRGEREVADASLTQAKARLSDEVQQVNADIRDSILDIQSAAKLVDATKSNVDLATEALSEAQQRFHAGISDNLPVSQAQSQFEQANDQYISALYQHNVAKLTLARALGAAQTNYKDYLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL3</accession>
    <name>E8WVL3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69542">
        <property type="protein sequence ID" value="ADW69542"/>
        <property type="gene ID" value="AciX9_2510"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2510"/>
    <dbReference type="HOGENOM" id="CLU_2395587_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="9417" checksum="E68E3997BB6428AE" modified="2011-04-05" version="1">MSRQIGVGSATTPGLKPICLLSVDGGLKPPSNPNGNGNGNGNGNGNGNGNGNGNRNRNRNSNGNGNGNGDGNFYCYRKWLGGGSVLWGRAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW97</accession>
    <name>E8WW97_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1422</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1422"/>
    <dbReference type="EnsemblBacteria" id="ADW68480">
        <property type="protein sequence ID" value="ADW68480"/>
        <property type="gene ID" value="AciX9_1422"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1422"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_0"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="110"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="31940" checksum="002DD907DCE6CB4E" modified="2011-04-05" version="1">MDLLPRRLPYGCDQKTHQPDFQMHPELTPADLSLEVVSPTERDSHSDTLFPVSSNPVASSPTSLPPVLQSIRRNIVECTRCERLRLYGEAIGAARRRAYIDQVYWAKPVPGFGDPRARILILGLAPGAHGANRTGRPFTGDGSGFFMYPVLHSLGLASQPTALSADDGLKLRHAWIASVVRCAPPGDKPTPQEVRNCSSHLAAEIAALPRIRTVVCLGKIAWDGYLAHLVNTGILQRRSPYVFGHEAEYILPNGLHLLGSYHPSLRNTNTGRLNATMFARVFVRARELSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA6</accession>
    <name>E8WWA6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1431"/>
    <dbReference type="EnsemblBacteria" id="ADW68489">
        <property type="protein sequence ID" value="ADW68489"/>
        <property type="gene ID" value="AciX9_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1431"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701633_0_0_0"/>
    <dbReference type="OMA" id="LQADNQM"/>
    <dbReference type="OrthoDB" id="1130871at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229988" evidence="2">
        <location>
            <begin position="32"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="101"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="43440" checksum="5F0DA5ECCCD613C5" modified="2011-04-05" version="1">MNMPRPAFRDLSLALATVFCALLLPFPPAHAQTPGQTPAQKPAQAPPDETGPQTDNGPLIIKKKSTEEPAPPPPASDVPKLKNPDGATYSLRVDVPIVNLNVNVILDKTHQFVPGLKADNFLVLEDGVEQKVQTVRMTQTPITAVMLLEFAANSYAYIRDMQYSSAAFYHSLRPDDYIAVITYDLRTHILTDFTNNKDTVAQSLNSLQIPGFSDTNMFDALYETLDRTSRIEGRKYIILIGSGRDTFSKLTLDKMLAKIKATPNVTIFSIGTGALAQELGDARGQIGGIGRMNILQAQNQLKTFATMTGGLYFDPMFQGALPDIFSQINDSIRNQYILTYRPSNPKNDGTYRKIEVLLVDAEGKPLKMQDEKKKPVKYSVIARDGYKAKLPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK6</accession>
    <name>E8WWK6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2645"/>
    <dbReference type="EnsemblBacteria" id="ADW69670">
        <property type="protein sequence ID" value="ADW69670"/>
        <property type="gene ID" value="AciX9_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2645"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_1_0"/>
    <dbReference type="OMA" id="SAKWKLE"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="37994" checksum="1BF92BA7F5A33E1C" modified="2011-04-05" version="1">MPQVSSIHDRYSRQILFPGIGSRGQELLAQARVAVVGVGATGAASASLLARAGIGHLTLIDRDFVEFSNLQRQILFDEADAQAALPKAEAARRKIALFNSSIVVETAIADLVPANVSEYLQSADLILDCTDNFETRYLLNDYAVREAKPWIYAAAIGAYAATMNILPAPSAKWEPTACLACIFPAPPSGPVETCDTAGILSTAVNLAASIQTTEALKFLTGQTSLMRRTLLSHELWTNQRSEIATGRPLSDCPVCSDRVFTHLAGTARPHITLCGRNSVQIHEHHRPLDLAALQATLAKNPDLQDIRANAMLLRFRRDSNTITVFPDGRALIQGTTDISTARTLYARYIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK8</accession>
    <name>E8WWK8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2647</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2647"/>
    <dbReference type="EnsemblBacteria" id="ADW69672">
        <property type="protein sequence ID" value="ADW69672"/>
        <property type="gene ID" value="AciX9_2647"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2647"/>
    <dbReference type="HOGENOM" id="CLU_2219410_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="11610" checksum="61BDB33DE2F3D3C5" modified="2011-04-05" version="1">MNDKEIPGSQKPIDDTTIAETTEGSASYSGQPDDLHDLFAVHASANPDEEDPLAALRSDPNYSALIRDLEYIAKQARLLFEPAQEAPSDEVWNKIQSQLGTKLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWL4</accession>
    <name>E8WWL4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3759</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582067.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3759"/>
    <dbReference type="EnsemblBacteria" id="ADW70759">
        <property type="protein sequence ID" value="ADW70759"/>
        <property type="gene ID" value="AciX9_3759"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3759"/>
    <dbReference type="eggNOG" id="COG2268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038134_0_1_0"/>
    <dbReference type="OMA" id="ERQYDSE"/>
    <dbReference type="OrthoDB" id="534274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="53784" checksum="BD3842BA1D0D9F68" modified="2011-04-05" version="1">MHSLIVPIVGLSVAVIIILLVSIGRMFRKAAPNQAIIVYGFRKPRVIKSGAAVIFPVVETYRELSLELMSFDVAPQQDLYTKQGVAVTVEAVAQIKVRSDEESILTAAEQFLSKTATEREGLIRLVMEGHLRGIIGQLTVEQIVKEPEMVAERMRATCMDDMSKMGLEVISFTIREVRDKNEYITNMGRPDVARIKRDAEIASAEAERDTAIRRANALREAAIAKAASDQDRVIAETASLGKQAEAQRDLDIQKAQYTEQSRRQEAQADKAYELQTNVMQQQVVAEQVKVQQIEKEQQIKVQQAEILRHEAELTSTVLKGSEIEARRIQNIAAAEKARITIEAEGRAAATRAAGEAQAAVTRLQGEAEADIIFQKGNAEAKAMNVKAEAYQEWSQAAVVDKLITNMADVVRAMAEPLANVDKITIVSTGSDDQTGASKITGDMTRIAAQVPALFEALSGMKMSDLMSNVKAMKPRDSSKDIDADTEKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT1</accession>
    <name>E8WWT1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0337</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578737.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0337"/>
    <dbReference type="EnsemblBacteria" id="ADW67409">
        <property type="protein sequence ID" value="ADW67409"/>
        <property type="gene ID" value="AciX9_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0337"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_0"/>
    <dbReference type="OMA" id="GAFYGQS"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="280" mass="30615" checksum="9EDD25C72116DB41" modified="2011-04-05" version="1">MQSFLLANDLPLSRIGYGTMRLIADGAWGPPLDPTAAKAILHRALDLGVNLIDTADAYGPQELERFIGETLAPYPAGVVIATKAGLARMAPAKSEPLGRPSYLRQQVEMSLRYLKLEQLPLWQLHRIDPQVPLEDSLGMIRDLQQAGKIRHVGLSEVNVAQIEQARRILPIVSVQNKYNLTERKHEAVLDYCTQNNIAFLPWYPVAAGKLNAPGSKLAAIATRLGATPTQLQLSWLLHRSPVIVPIPGTSSLAHLEENCAALNLTLTPQDLQEIESAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX16</accession>
    <name>E8WX16_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579896.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1524"/>
    <dbReference type="EnsemblBacteria" id="ADW68577">
        <property type="protein sequence ID" value="ADW68577"/>
        <property type="gene ID" value="AciX9_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1524"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_0"/>
    <dbReference type="OMA" id="NPTGHFL"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="41931" checksum="9A1466224FE09DCE" modified="2011-04-05" version="1">MPVRFSKRTAWDTGESTLAEAVRQVRSSGRSLIDLTLSNPTLCGFEYDSAAILGALTNPAAMTYDPDPRGLTSARRAVSQYYADNNALVDPAQILLTTSTSEAYSFLFRLLCDPGDEVLVAQPSYPLFDFLADLDDVNLKPYPLFYDYGWWIDFAELERRIGPRTRAVLLVHPNNPTGHATGRAERERLEAICAEHGLALIVDEVFLDYSLGEPVESFATGPHPALTFVLSGLSKISALPQMKVGWLACQGPGELVAEAFGRLEVIADTFLSMNAPAQHALPTWLASRESIVPQIVARTQTNLAALAAAGLEALPVQAGWSAVLRLPVVAEGRIDALVQEAGVIVHPGSFYALPGKNQIVVILIGPVTEFAEGVLRLARWCESNSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX75</accession>
    <name>E8WX75_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP family containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2693</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2693"/>
    <dbReference type="EnsemblBacteria" id="ADW69717">
        <property type="protein sequence ID" value="ADW69717"/>
        <property type="gene ID" value="AciX9_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2693"/>
    <dbReference type="eggNOG" id="COG5507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097061_1_0_0"/>
    <dbReference type="OMA" id="WNAFQAD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="16009" checksum="F31F305D00B9F34D" modified="2011-04-05" version="1">MDRRDLLKVMGAMATITMLKGTAMSEVTSETVYELRIYHLNEGKLPLILNRFRTKEVAIFKRLGMEEVGYWTPTDEPLANRTLIYMLKHKSRAAATESWAKFKVDPEWVALKAETEKDGTFVIKNESTFMKLTDFSPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX81</accession>
    <name>E8WX81_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2699</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581038.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2699"/>
    <dbReference type="EnsemblBacteria" id="ADW69723">
        <property type="protein sequence ID" value="ADW69723"/>
        <property type="gene ID" value="AciX9_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2699"/>
    <dbReference type="eggNOG" id="ENOG5033F5Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359843_0_0_0"/>
    <dbReference type="OMA" id="MRPSHER"/>
    <dbReference type="OrthoDB" id="2101591at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="22190" checksum="CB9BC42440E72F7F" modified="2011-04-05" version="1">MIEPNDNYEREIDRVLAGLRQVEPGTGMEARVLRRLEERAEAKAASLWMFRLAWGGGLAVAVVAIAFAVQHSGQRAAAPDVVAHAVAPIAVTRLHSVPVAPALIVEGMRQPRTGRVRAVQADVATTQPDAMAESFPAPPLPLTQQEKLLIRVAHHGDEVPVTPPPSIARGTEIAELRADSDKFFQDPTTGENQWKRIVAEQAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD2</accession>
    <name>E8WXD2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0393</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0393"/>
    <dbReference type="EnsemblBacteria" id="ADW67465">
        <property type="protein sequence ID" value="ADW67465"/>
        <property type="gene ID" value="AciX9_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0393"/>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="5643" checksum="10FBDE40CB0408BA" modified="2011-04-05" version="1">MALLQGQVDLLVCPVCFGRLVLAETTVRCEGCGRVYPVVDGLPVLLADRAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM1</accession>
    <name>E8WXM1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pal</name>
        <name evidence="8" type="ordered locus">AciX9_1584</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579956.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1584"/>
    <dbReference type="EnsemblBacteria" id="ADW68637">
        <property type="protein sequence ID" value="ADW68637"/>
        <property type="gene ID" value="AciX9_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1584"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_9_0_0"/>
    <dbReference type="OMA" id="FCTEQNE"/>
    <dbReference type="OrthoDB" id="1544679at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OmpA-like" evidence="7">
        <location>
            <begin position="166"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="29545" checksum="1EE3A92699366DDE" modified="2011-04-05" version="1">MTSLLTLNKHNTEPKTLNFSKHSALRTLTLLAIAGTSLSLVTGCHKKNSGIDPSSLGPTNTTDNTPIPAPTATITADPLAIDLGQTVVLNWRTMNASSVSIDGIGQVNVNGTQTVSPSNSTNFHLVAKGDGGTTEANVRVTVRTSSVPVGGTTSGLDAAANGGNVTDAAFHAAVQDVFFDYDSIELRPDGQTAAVQAATYMSQHPNLHILVGGYCDERGSAEYNLALGENRANAAKTALVNAGVAANRIRTISYGKEKQFCTEANEACWQQNRRAQFSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS4</accession>
    <name>E8WXS4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2745</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581084.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2745"/>
    <dbReference type="EnsemblBacteria" id="ADW69769">
        <property type="protein sequence ID" value="ADW69769"/>
        <property type="gene ID" value="AciX9_2745"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2745"/>
    <dbReference type="eggNOG" id="ENOG502ZJ3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203343_0_0_0"/>
    <dbReference type="OrthoDB" id="2095452at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6489" checksum="C02F2814AAEB9FBE" modified="2011-04-05" version="1">MTFPLSVCIGFFLGFVFGVGCALAVMYSIYMGGYRAAVRDSILPTQPERLTKALAKLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT0</accession>
    <name>E8WXT0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2751</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69775">
        <property type="protein sequence ID" value="ADW69775"/>
        <property type="gene ID" value="AciX9_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2751"/>
    <dbReference type="eggNOG" id="ENOG5032T4J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113748_0_0_0"/>
    <dbReference type="OMA" id="VRANYEY"/>
    <dbReference type="OrthoDB" id="1726286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233473" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21608" checksum="93C500B7215CBDFA" modified="2011-04-05" version="1">MGDLPLLTRFLAALTLFACSVPMLHAQAKYTAARTGDFQVGVDFAGIHSDYDPKLYKGYGLYTTFDLTNHLGAEFDFNQGSASSPNKDYERTYELGARYFRTYGRYSPYAKIMYGRGVFNFAPLGPVNANLAYNEAVIGAGVDVRVLRYINVRANYEYQDWFGFPANGLNPQVFNVGVAYHFPGGLGRGQHYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY15</accession>
    <name>E8WY15_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0482</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578882.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0482"/>
    <dbReference type="EnsemblBacteria" id="ADW67554">
        <property type="protein sequence ID" value="ADW67554"/>
        <property type="gene ID" value="AciX9_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0482"/>
    <dbReference type="HOGENOM" id="CLU_1608525_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="18398" checksum="9553734EDA6EE211" modified="2011-04-05" version="1">MVTSDNKHGAKEEAFPASSSRRRSLVLYLLPLILVPYLLLLIALFLVPSRWLAVRSGNTYLANLGYGATLHHADCQIVVYGDSTAMVGIDPAVLRERTGLSACNIAEFEGMTILNGTMIVDQYLAQNQRPKYLVFLYTPEDFQPESQRAMVGMFEGLTWRFGQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY52</accession>
    <name>E8WY52_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="12" type="ordered locus">AciX9_1627</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1627"/>
    <dbReference type="EnsemblBacteria" id="ADW68679">
        <property type="protein sequence ID" value="ADW68679"/>
        <property type="gene ID" value="AciX9_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1627"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_0"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="122"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="257"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="485"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="548" mass="59418" checksum="B513B85103C596CE" modified="2011-04-05" version="1">MISTARKTHEPLLASLEPKLPHSHPNPLQGIPQANTTHSSVLIRLPLSYPRYAFPFIRSQSHFARIAQVKPPPIELVNTIAGATPGSAPIPVDRRPKLNDRLRHRIVAASTYSDSKENMTDIVSITAREILDSRGNPTVEADVLLSGGAMGRAAVPSGASTGEHEAVELRDGDESHYLGKGVLSAVDNVESILSPELIGMDATNQRLLDATMIAIDGTENKSRLGANAILAVSMAACRASSAALKLPLYRYLGGVNACLLPTPMMNILNGGSHADSNVDFQEFMIMPVGAETFSDALRQGTEVFHTLKSVLKKKGYSTAVGDEGGFAPNLKSNAEAIELILEAIEKLGLTPGEDIAIALDPASSEFYNKETGKYVFKKSDKSERDSHQMADFWIDWARQYPIVSIEDGLAEDDWTGWQYLTEQIGGNIQLVGDDLFVTNTQRLRQGIEQKCGNSILIKVNQIGTISETLDAIELGRRFGFTSIISHRSGETEDTFIADLAVGTGAGQIKTGSASRTDRIAKYNQLLRIEEQLGQSAEFLGIESLNYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY93</accession>
    <name>E8WY93_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1670</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580039.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1670"/>
    <dbReference type="EnsemblBacteria" id="ADW68720">
        <property type="protein sequence ID" value="ADW68720"/>
        <property type="gene ID" value="AciX9_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1670"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_0"/>
    <dbReference type="OMA" id="TTISWWI"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="301"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="807" mass="86254" checksum="3AE5814E7B83C544" modified="2011-04-05" version="1">MLPFASDLRFAIRQLRRSPGFSLLAIVTMALAIGVSTAVFSVLDAMVVRPLPYKNPDSIVVLRTWSPQGYGQPASWLQYLDWRRENKTLSALAGYGMDSINMESGQSATPVRAVSGTDNFFDVFGVQPMLGRTFRTGEDKAGHNDVVVLSYELWKQTFGADRNIVGSKIRLDGTPTEVIGVMPAGFRYPLSVSNALYRPFHLPATRIATRGQHFLPTIGRLKDGVTMSQAEADMGQVFQNLGRLYPDEAGRRVHLLSESEASLGKTGGPLRVLVLSVFGVLIIGCVNIAGLLLVRGVRRQREFALRSAIGAGRGRIVRQLLTESAVLSLAGAAGGVLLAAGMLQVMRQLLISSLSRGADVELNLPVLAAAVVIALVTGLTAGTLPALQFSRLAPAMALRSGGAAGSSLGQNRLRFTLIAVQIAIAMGLLVCSGLLLRNLHDMRSTSLGFSPDKLLTEEVTLTAANYVGRDMVTSFYNPLLERVRALPGVAGAGMINLLPIQESGSNGDMHIVGKPPLAPNQEMLAEIRSISPGALEAIGAHLIKGRTISGSVDHAGAPINVTVNEAFVHKFFSPGEEAVGRQIDWGNDKITIVGVMSNLRQDLGQPSMAEMDLPAAQIPAEYASSELLHMTLVVQVANGDPASVSNALREAMHQIDPSVPFRAPLTMNQVVAETLTFERLESWLFGIFAVLALTLSLVGIYGMVHHEVELQTRDIGIRMALGSSRTRVVRQILTRVTLLLTAGLGCGWLLTLAMQRTISSVVELHATQNASLLGGLTLVLAFFGVAAGLLPARRAASISPTEALRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY94</accession>
    <name>E8WY94_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1671</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580040.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1671"/>
    <dbReference type="EnsemblBacteria" id="ADW68721">
        <property type="protein sequence ID" value="ADW68721"/>
        <property type="gene ID" value="AciX9_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1671"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="NWNQMRQ"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26782" checksum="0D2757DFAC77BF7C" modified="2011-04-05" version="1">MSESLININGLTKVFYTDEIETHALSGIHLGIARGEYVAMSGPSGCGKSTLLSILGLLDTPTGGEYTLNGKQVANLSFAERSRIRNQEIGFIFQSFNLIGDLTVFENVELPLTYRAGMAGSERKDRVSKALERVGMAHRMRHYPAQLSGGQQQRVAVARALAGSPSILLADEPTGNLDSKNGEAVMTLLAELHAEGSTICMVTHDNRFAAHAQRQIHLFDGKVVAEGELAHLLADPIQNPSTISRVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC7</accession>
    <name>E8WYC7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2810</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2810"/>
    <dbReference type="EnsemblBacteria" id="ADW69833">
        <property type="protein sequence ID" value="ADW69833"/>
        <property type="gene ID" value="AciX9_2810"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2810"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495887_0_0_0"/>
    <dbReference type="OMA" id="QQATEYT"/>
    <dbReference type="OrthoDB" id="362773at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233485" evidence="2">
        <location>
            <begin position="31"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="549" mass="59524" checksum="55BACAF2EF8D19C9" modified="2011-04-05" version="1">MLKPSFSRLLASSALLITALAAPLRSQAQASPSAADEKQPGGHVVLVLPFDNRSGNPNLNWIGDSFPDTLNQRLGSAGFLTISRDDRQFALDHLGLPVDFRPTRATTIRIAQTLDADYVIVGSFNTQGTGTNIRILVQAQVLEVNKLHLSQPLQDSSELPRLFDIENAIAWKVARQIEPGFTVAEQTFLSASAGIRLSAFENYIRGTSATASDERTKRLEVATLDAPTYAAAQLALGKQYYADRSYDKAAATLAHVPSSDRLSLEAGFYLGLSRFNAAKYAEAETAFAFVASRLPLPEVVNDQGVAQSRQNKDASALFQRAVTADPGDPDYHFNLAVATYKRGDFATASREIQAALKLRPNDNEFKQLQTLISAGRATKPVGDGFDPTTRLRRTYSEASFRQAAFQLDQMRSMRLATLPPKQQGAEYTQLGQDYMAQGLVPEAEEQFLSAIQADPSNATAHTGLAQVRQLSDSPDDARKEAMASIRLAPSVNAYIVLAKVDLQKNELAAASTDVQNALKLEPRNAAVLQLQQAIQAKSQAPAATPQAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD6</accession>
    <name>E8WYD6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2819</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2819"/>
    <dbReference type="EnsemblBacteria" id="ADW69842">
        <property type="protein sequence ID" value="ADW69842"/>
        <property type="gene ID" value="AciX9_2819"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2819"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_0"/>
    <dbReference type="OMA" id="CGAGLYI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="233" mass="25237" checksum="A8DD9615A151D723" modified="2011-04-05" version="1">MIPSSFHFSQLDQLRLSSGTATRLLTSILLGGAIGLEREWRHKASGLRTNMLLCLGCAFFTLLSANLAGEGNPNKGQVASNIVQGVGFLGAGLILHTRSRVLGLTSAATVFVVASIGMACGAGLYIEAVMATVMVLVALQLIGVMEYRMPWKQSVLLYEVRGLHESVMYPAILDVMDKAGLRMNVVDRDSFGSLERVTFMVTATRHRHAVLLKDLRDSDATDHVTAYPDAEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK1</accession>
    <name>E8WYK1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0527</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578927.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0527"/>
    <dbReference type="EnsemblBacteria" id="ADW67599">
        <property type="protein sequence ID" value="ADW67599"/>
        <property type="gene ID" value="AciX9_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0527"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OMA" id="WIYINAK"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="404" mass="43832" checksum="0100D80AD68EEBC6" modified="2011-04-05" version="1">MNQISHVDQCNSPTTVRRLGRAAFCCSLAFLSAAAFGQKTGHAALVDPSLPKYTSEPVTPPKPGDRGYVMPDGSIRIVGFDDMAGMVDRWDKLFTSTHANVKFTPILKGNGTGIPAITYDMSLLAPEGGGATLLDLLPYEKIYGSKKDPVAALIIRVAHGSLNPTAKMSPLGIIVNKSNPIKSLTLAQVASMFSTGSGSGDVTGWSQIGMGGSFAEKPIHPVGLYYDAYQRPEDDHMGEYMMYRKMGKFPGSVFSPRYEQFLHYDDVVKSVAGDPLAIGIVALNKVNSSVRVVPMVGNDGHTLTTGTVKELMANEYPYERDLYLYIRREPGTPLDPLVKEYVRLALSKAGQEAVAQDAKGYLPLNAADAKKELEKLDRASTWAPRSKQGPKLNFPFPSPEPEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL5</accession>
    <name>E8WYL5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578941.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0541"/>
    <dbReference type="EnsemblBacteria" id="ADW67613">
        <property type="protein sequence ID" value="ADW67613"/>
        <property type="gene ID" value="AciX9_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0541"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_1_0"/>
    <dbReference type="OMA" id="GYNQSEC"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="239" mass="26180" checksum="9B195BDB399DE05A" modified="2011-04-05" version="1">MECGRCGDALDLDLDMEDARFSGMLKEGLLCRECRLAPPDFTRAVAYGVYSEELRELIHLFKYEEVTGAARLLGGGLSEAVLSLEGKMADHALVVAVPLFVRSQRRRGYNQSRLLADAVLKELRGKKLKAAHGVLVRRKSTESQFALSRKARRRNLRGAFEVRGDVANKEVLLIDDILTTGATARECARVLVKAGASKVWVATVARAQSERITAQQRNPGAYVAGWDLKPGPTHSFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ7</accession>
    <name>E8WYQ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1694</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1694"/>
    <dbReference type="EnsemblBacteria" id="ADW68743">
        <property type="protein sequence ID" value="ADW68743"/>
        <property type="gene ID" value="AciX9_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1694"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017432_0_0_0"/>
    <dbReference type="OMA" id="VHEMPEP"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002102">
        <property type="entry name" value="Cohesin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00963">
        <property type="entry name" value="Cohesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230469" evidence="4">
        <location>
            <begin position="38"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Cohesin" evidence="5">
        <location>
            <begin position="690"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="819" mass="87118" checksum="3D630A7A0CF1A0BB" modified="2011-04-05" version="1">MSRGLQTFRHHNVLTARTVLSFCIFMFGLCAILPAHAQSASKWNKRGVDAEAHEDYDAAYEDYRQALKKSPKDIRFKTHLERMRFQAAVSHIDRGRVLRQSGDYSGALTNFMRAAEIDPGNQTAQQEIGITQREQPAPVPVGPGADAAAAQLTQQTSVLQNIASISAPVVLKPTSSDRQTLHMVEDVKNIYQAIGKLAGINVIFDPEYTSKRIPIDLTNVTLDDALRIVGTISGTFYKPVTSNTIFVAQNTRTKRTDLDELAVQTFYLSNSAQANDGNEILTGLRLLLDPTVKLYLVPSQNAIVMRGTTDELLLAQKLINDFDRARPEVVVDVAVLEVSRDKVRTLGITLPQSIGLTPQLSNANSTSTTSSTTTTSTTTTSSTTTSSTSSLTLNNLAHLNATNFAVSITGGTLNALLTDGDTRILQNPRIRATDGQRATLKIGSKIPIATGSYNAGVSTGVASIGVQTQFTYIDVGVNIDITPTVHYDREVSMKMKIEVSSQSNTVVISGVSEPIISQRISEQVIQVQDGEPSILAGILTHQDSKTVSGTPFLGELPFFKYFFSTQSKETQQDELVFLIIPHVVRESVLTRLNTAMIDTGTGSSIELRHMDTSAAETALSNAAAAQASVPLPQHAGAPSTAANAAANMLQQIHQDAQPPTPGQMPGAIPPTPAATAAPAGTNGPISLTVVPASSNQTVGSTFQAAVNLQNGRDVFSVPLQVQYDPKVLELVNVDAGDFLSKGSQPVSLVHRVEGNGLVTISSTRPPQAAGVDGQGSVCTLTFKAIGAGDSNIALVKVGAKNSAQVNLPAVGSQAVVHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX2</accession>
    <name>E8WYX2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kduI</name>
        <name evidence="6" type="ordered locus">AciX9_1760</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1760"/>
    <dbReference type="EnsemblBacteria" id="ADW68808">
        <property type="protein sequence ID" value="ADW68808"/>
        <property type="gene ID" value="AciX9_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1760"/>
    <dbReference type="eggNOG" id="COG3717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062609_0_0_0"/>
    <dbReference type="OMA" id="TFIWAMA"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="285" mass="31633" checksum="5917FA37BD05487E" modified="2011-04-05" version="1">MVGIDEGIYMKTVEMADKVRYSRMTTGELRETFLLEELFKAGSVELAYVDLDRTVVGGAVPTIAALKLETQPELRAEYFCERRELGVLNVGGAGSVSVDGKSFELDKLDCLYVGRGSKDVEFTSKSAEEPACFYLLSYLAHKEYPTAMVKFADLDGLKLGAVETCNKRTIYKAIYKDGLQSCQLVMGFTLLDPGSNWNTMPPHTHMRRSEVYLYFDMDPAHKVIHLMGPPDETKHLMVSDKQVVVSPGWSIHSGVGTKNYTFCWGMGGENQAYDDMDAATIAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY6</accession>
    <name>E8WYY6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5666 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2878</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2878"/>
    <dbReference type="EnsemblBacteria" id="ADW69901">
        <property type="protein sequence ID" value="ADW69901"/>
        <property type="gene ID" value="AciX9_2878"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2878"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674020_0_0_0"/>
    <dbReference type="OMA" id="MRSADIA"/>
    <dbReference type="OrthoDB" id="1609676at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233997" description="DUF5666 domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="3">
        <location>
            <begin position="141"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="37403" checksum="FC8937AFDEEE1DC6" modified="2011-04-05" version="1">MFTRSIATRLMFLCTVAAAPVLFAPAALYAQAPANTSQRGTVKAISGTSITVTTEANSEITVTPADNAKILQLAPGSTDLKSAAPITLTDIAPGDRILISGHAGDAPTSIVAVRVILMKSTDIASLHASQSADWQRRGTGGLVRAIDASTITVAAGAKTLNVNVTPNTTYRRYAGDSVKFEDAKPGTLSDIHTGDQLRVRGAKSEDGSSITAEEIVSGSFENLAGAISAVDQKMGTVTLKDLATKKTVVVTVTPNSVVKHLPEQAAAAYARSHAPGAAVPAGTTPSPEGGGRRAGMDLSQMVGRLPAQSLTEIKAGDAVLIVASRTGSSATAITMLSGVEQLLSAPGAAAPTLSPWSLGGGGAEAGGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ1</accession>
    <name>E8WYZ1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="5" type="ordered locus">AciX9_2883</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581221.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2883"/>
    <dbReference type="EnsemblBacteria" id="ADW69906">
        <property type="protein sequence ID" value="ADW69906"/>
        <property type="gene ID" value="AciX9_2883"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2883"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015798_0_0_0"/>
    <dbReference type="OMA" id="RPNFWPN"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="215"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="546"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="680" mass="77183" checksum="C51F2312361A0B91" modified="2011-04-05" version="1">MKPVEGRARVVIEEVKPQVDGGRYPVCRIVGDTVDVSAAIFGDGHDHLSARLLYRQKGEKRWRSAAMRELGNDLWSASFEVDKLGSWSFTIQAWVDHFDTWTSDLKKRLAAQPDPQQPTQIGVPQDIPLALRTGALLVEAMIGRAKGADARALTEMVTSLRWMAEQDAALYEYPLTPEFEALAARYPDLTLATKLEKEAEIWVNRDRARFSSWYELFPRSMAKTPGAHGTLQDVIGQLPEVSAMGFNVLYMPPIHPIGTAFRKGKNNSTTAEPGDYGSPWAIGAAPTKDNDGGHKAIHPLLGNFKDFDELVHAAKAHDMELALDIAFQCSPDHPWVKQHPTWFTIRPDGTIQYAENPPKKYQDIYPLNFESPDWRDLWDELCSVFEFWIKRGVKIFRVDNPHTKSLHFWEWCIGTVREKHPDVIFLAEAFTRPHVMYSLAKGGFTQSYTYFTWRTAKAEIETYLEEITQPPVSDFFQPNFWPNTPDILHRSLQVGGRAAHMQRVILAATLTANYGIYGPAYELSENAPMKPGPGKTETEEYLDSEKYEIRQRDRNAPGTLVPLITRLNHIRRANPALQSNNSLCFHKVDNPNLMCYSKSAPDGTGGENTILVAINLDVTQEQAGWIDLDLKRLNIPHNENFDIEDLLTGVHYQWHDRSNYVALRPEVQPAHIFRITRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ8</accession>
    <name>E8WYZ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase</fullName>
            <ecNumber evidence="3">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581228.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2890"/>
    <dbReference type="EnsemblBacteria" id="ADW69913">
        <property type="protein sequence ID" value="ADW69913"/>
        <property type="gene ID" value="AciX9_2890"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2890"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041115_1_1_0"/>
    <dbReference type="OMA" id="EDDLSWG"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="185"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="38793" checksum="441F561674FB728D" modified="2011-04-05" version="1">MIERRQIVALWQAGRADVLITLVRVEGSSYRKAGARLLTDGSGGYAGTVSGGCLETDLVRKAAWMVRNGPIVERYAMTFDDTAEIPFGLGCGGTVDLLLEPLDTPEAQALGHAMAASLIGVESTVVSFLPGNGRGLRRLILAADGSIIFASPGLSPEKIACASRLSPGEPYDGRFVERLAAPQRLFVLGAGDDAKSVVRLASLLGWSVIVADGRSQLARQERFPEAERVLTASSAGSLGIRPEDAVVLMTHSYEQDRALLTSTLPFRPRYLGLLGARHRSSLLISEAALELGRSVESCCADVFAPVGMDLGGDGPEAIALSIVSEIQALCHGRRGPSRRLTSLEVAEHIQRGGASRYLQVECSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ01</accession>
    <name>E8WZ01_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2893</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2893"/>
    <dbReference type="EnsemblBacteria" id="ADW69916">
        <property type="protein sequence ID" value="ADW69916"/>
        <property type="gene ID" value="AciX9_2893"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2893"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="31418" checksum="262E6F5DEF2675C5" modified="2011-04-05" version="1">MNPLVRRLVSRVGRLVSLMVLAALGTIALMRYAPGYFTDAREMDAQYAGSARTELQLEQAQHGTFAQLTRELLGGWMHRDLGRSRHFDVPVTELMTPRLRVTGKLLFCGVAGGWLLALTLALPLSARRTASGEGAIAAPTALLLAMPVGALATGCLLADFGGPVLVLSTLIAVRDFKLIYRLLRQTWRSPHFLYARALGVSTPRIMRVHLLPRLTNELVALATMSFVLALSAIVPVEVIFDVPGLGQLAWSAAMNRDMPVLLAVTLLMAACIGVATMLAEPIQRAEAIPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE4</accession>
    <name>E8WZE4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1784</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580151.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1784"/>
    <dbReference type="EnsemblBacteria" id="ADW68832">
        <property type="protein sequence ID" value="ADW68832"/>
        <property type="gene ID" value="AciX9_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1784"/>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_3_0"/>
    <dbReference type="OMA" id="MYSFIET"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="22950" checksum="F7F4C37F8CE2CE58" modified="2011-04-05" version="1">MDVGALILTLRLAGMTTLLLLIVAVPLAWWIARGRGFGRAGVQAIVSLPLVLPPTVLGFYLLVMLGPQTAIGRGIIDVIGHPLAFSFSGLLVGSCIYSLPFAVQPLVAGFRGLDGRYLEAAAGLGMSPWVSFRRVVLPMVSGSMLAAGVLAFSHTVGEFGVVLMLGGNLPGATRTLSIVLFDQVQDFNYAGANQTAAVLLCLSLAALIAVYAGRGRGGDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK4</accession>
    <name>E8WZK4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="9" type="ordered locus">AciX9_2955</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581293.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2955"/>
    <dbReference type="EnsemblBacteria" id="ADW69978">
        <property type="protein sequence ID" value="ADW69978"/>
        <property type="gene ID" value="AciX9_2955"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2955"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_0"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="25846" checksum="BDC520427EFB9412" modified="2011-04-05" version="1">MSVVGILGKKIGMTQIFDERGDVHPVTVLKAGPCVITQLKTMAKDGYDAAQIGYVDFVKASKVTKAMNGHFAKANVPPVRMIKEVAIQKASAEDAEVKAGDRILVDIFENERFVDVIGTSKGRGFAGVIRRHGFGGGPKSHGHMFQVQGSIGASSFPSRVFPGQRMPGHMGDAQITVRNLRIRAIDVEDNLILVEGAVPGARDGYVLISKAKAPPRERRGFAGAATKDALKASKKAAPSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ8</accession>
    <name>E8WZQ8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2383 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581346.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3011"/>
    <dbReference type="EnsemblBacteria" id="ADW70032">
        <property type="protein sequence ID" value="ADW70032"/>
        <property type="gene ID" value="AciX9_3011"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3011"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114531_0_0_0"/>
    <dbReference type="OMA" id="SHDYVKA"/>
    <dbReference type="OrthoDB" id="1769096at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011971">
        <property type="entry name" value="CHP02284"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019052">
        <property type="entry name" value="DUF2383"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016920">
        <property type="entry name" value="UCP029477"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09537">
        <property type="entry name" value="DUF2383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029477">
        <property type="entry name" value="UCP029477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02284">
        <property type="entry name" value="TIGR02284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2383" evidence="1">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17437" checksum="A922E1472A399AB3" modified="2011-04-05" version="1">MSTDADKNSEFEKILKEVINVLQDGQKGFADLGEHLKDDTVKRYFLAESLKRANFRAELENELHRHGVKDVHEEGTALGAIHRTWGDLKAKISTPTDHSLLATAEQGEDKAKATYKDALDQELPLPIRQLLTEQQAHILTSHDYVKAHRDALASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ2</accession>
    <name>E8WZZ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASPIC/UnbV domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1841</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580207.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1841"/>
    <dbReference type="EnsemblBacteria" id="ADW68888">
        <property type="protein sequence ID" value="ADW68888"/>
        <property type="gene ID" value="AciX9_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1841"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017657_0_0_0"/>
    <dbReference type="OMA" id="AHGESNT"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230506" evidence="2">
        <location>
            <begin position="30"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="UnbV_ASPIC" evidence="3">
        <location>
            <begin position="533"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="613" mass="65875" checksum="D9AB3DB757AAA387" modified="2011-04-05" version="1">MTVDLQIGNARGIVLLLLWLCALQHSAQAQGDSQKSGTMSVNTGAARAAVLDEKRRPITAGGFVSSGPHVFDDVAARAGLSSWRHRMGTPEKKYILETLGSGVALLDYDNDGWLDIYLVNGSTYEAMAGKAAPPQAALFHNNHDGTFTDVTAKAGVGNGRWGIGVVAADYDNDGWPDLFVSNYGENRLFHNNHDGTFTDVAKAAGVELGNLSTGATWGDYDGDGRLDLFVPGYVHYDLQHPPPAAGSAAAEGRCNFRGVNVMCGPRGLKGEPDHLFHNNGNGTFTDVSVKAGVSDQKAAYYGLASLFVDVNNDGRLDLLVADDSTPNYLYINKGDGTFEDASFASGYALNESGRETASMGIAAGDMLHNGLIDLFNTTFSDDYKPLYRNDGDGNFTDVSYQYGIAEPTIPFLGWGTGFFDYDNDGWLDLMSVNGHVYPAVDETNWGTSWKQRLLLFHNNAGKLSVVPPVEGSGLAKVASARGMAYGDLFNDGHIDVVVNNMDEGPSLFRNVSDTVNHWIEFKMIGGSKSPRDAMGTTVYLTANGFTQRQDVISGGSYASSSDPRLHFGLGKSTTIAKIEIHWPSGLIEVVKQPGMDGIFKVTEGKGTVIKHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X027</accession>
    <name>E8X027_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1877</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1877"/>
    <dbReference type="EnsemblBacteria" id="ADW68923">
        <property type="protein sequence ID" value="ADW68923"/>
        <property type="gene ID" value="AciX9_1877"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1877"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466856_0_0_0"/>
    <dbReference type="OMA" id="WKWTLRS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="607" mass="63434" checksum="3B0F20D6D73B71A9" modified="2011-04-05" version="1">MENHLEKAIGAQRIPLQRTQGSQNESGVAVLGLVAALCFLAQPSRAAYASSAEEGGAALTGVVRDAQGVAQMGALVQVVAANATTIATAFTDQQGRYSIAGLLPGKYQVRASAALLVPATRGNLQLQMGSRSVVDLTLAALFDTASWLPASRRRADEPQDSWKWTLRSTANRPILRFDDDGSLIVVGAPESRAAARVEARGAVTGEAGEFGQDSVRSELELHEAFANGAVGMVRTSVGSSPNSMAGAGGAPSMEIDAEYERAAGYGGRSRTAVSYGSYANLVGPDGTAGLQVLKLQSGQQMALGEDVELEVGGSVEGVRGGGSYALATHPFVRLTAHPGGSWRLQYRMATDRATQEFADISARRQEAPAALAQNGQMLLEQGRHQEISASRKAGRAVVEVAYYHDAMVNTEVAGGFEQGISSSAAGPSDAEANPLLVDQASGGFRTLGSGYTSNGARFTVSVPLAPDFWVAAEYATGDALASEAGDATSVAEAVSGLKARSSQAAAVSVKGKLARSGTSIRASYRWQPDGTVTAVDPYGAMSDQAYLSCVVRQHLRWKDHLPQGLDATIDVTNLLAQGYRPFISADGHTLYFAQAPRTIQAGLSFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X065</accession>
    <name>E8X065_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3025</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581360.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3025"/>
    <dbReference type="EnsemblBacteria" id="ADW70046">
        <property type="protein sequence ID" value="ADW70046"/>
        <property type="gene ID" value="AciX9_3025"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3025"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_0"/>
    <dbReference type="OMA" id="ERKFDGH"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="28082" checksum="C917017DCE1F1458" modified="2011-04-05" version="1">MQSLRGKTVLITGASSGIGQATALEFARQGARLLLCARRLDRLTELTPQFTEAGAEDVLNIRLDVQDREAVAKTLADLPENWRTIDILVNNAGLSRGLAKLYEDDPQNWEEMIDTNVKGLLYVTRAIVPGMVERGSGQVINLGSTAGHQTYANGAVYCATKAAERVITEGLRIDTIGKGIRVTTVDPGMTETAFSEVRFHGDKDKAEKVYQNITPLQPEDIADAIVWAATRPAHVQIQTMVLTTIDQANSTTFNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X095</accession>
    <name>E8X095_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ordered locus">AciX9_3056</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581390.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3056"/>
    <dbReference type="EnsemblBacteria" id="ADW70076">
        <property type="protein sequence ID" value="ADW70076"/>
        <property type="gene ID" value="AciX9_3056"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3056"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_0"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14572" checksum="BFFC455FDBAE8028" modified="2011-04-05" version="1">MADLIQYYGTGRRKSSIARVFLRPGSGKFTVNKKDVDVYFVTPQQRVAARRSLGIAGIEETFDVLTTVRGGGVMGQADAVKLGIARALMEFNPELRKALKAEGLTTRDSRGKERKKYGQKGARARFQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X097</accession>
    <name>E8X097_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsf</name>
        <name evidence="7" type="ordered locus">AciX9_3058</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581392.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3058"/>
    <dbReference type="EnsemblBacteria" id="ADW70078">
        <property type="protein sequence ID" value="ADW70078"/>
        <property type="gene ID" value="AciX9_3058"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3058"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_0"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="6">
        <location>
            <begin position="61"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24063" checksum="90DC0179A527165E" modified="2011-04-05" version="1">MSTETAVKIDAKLVKELREKSGAPMGDCLKALQEAKGDMENAFVVLRKRGMASAAKKASRSTNEGAVGTYIHAGGKIGVLIELNCESDFVARTEDFQELLRDIAMHIAATDPRFVGREEVAQADLDREKEVFLAQPAMKGKPEAVISKILEGKMSKFYEEVCLLDQPFIKEASQTISQLIASKVAKLGENISVRRFARFKVGASDWTVAQTKIAAEEPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B0</accession>
    <name>E8X0B0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3071"/>
    <dbReference type="EnsemblBacteria" id="ADW70091">
        <property type="protein sequence ID" value="ADW70091"/>
        <property type="gene ID" value="AciX9_3071"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3071"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049429_0_0_0"/>
    <dbReference type="OMA" id="YVILIAD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="75"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="34423" checksum="948C8D3A8CB20A03" modified="2011-04-05" version="1">MPSGPPPKSNAPAQVEEDNPLQTLKIGTNLVNVYFSARDKNGFITNLKKDDCSVLENKDEQKIKNFTQEKKLPLTIGILLDTSGSQQNVLPLEQQSGAEFLKTVLTPKDEAFLISFDINVDLLSDYTNSPREIKRSIDKATINTGAGTGSVTGNSTPKGTLLYDAVYLAAHDKLRQEAGRKILVMLTDGGDQGSQETLKTATEAAQKANAIVYVILIADRGFYSGGGFSFGGDRDMESLAHDTGGRVINVGNNGRKLEDAFDQIQDELRTQYLLSYTPKDLEFNGKFRTINLDCGKGIKIQARKGYYAIPDGGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T2</accession>
    <name>E8X0T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3096</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581430.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3096"/>
    <dbReference type="EnsemblBacteria" id="ADW70116">
        <property type="protein sequence ID" value="ADW70116"/>
        <property type="gene ID" value="AciX9_3096"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3096"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_15_1_0"/>
    <dbReference type="OMA" id="KEVQITH"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="41879" checksum="0897A24D052F1217" modified="2011-04-05" version="1">MSDINSNHSRISVSLTVVALLILLCGGAFLWSRDHGSVSTDDAQVDGHVHPINARVGGTVVWVNPDIDDTKFVKAGTVLAHLDTNDYQPAIDRLEGDVQAQQAQLQTAELAVPITQTTSSSKLASAHDSEAEAEAELASAKAGVRAASAQVQQAEASSRRAENDRARYEQLVNSHEISRSEYDTRMTDANVTAAQLSAAQANLQAADQKVQAAEQHIAERKQDVLSAATAPELVATARSSVERVSGELKKSKAALHDAQLNLGYTDIIAPVSGIVGRRSIETGQRIAPGQLLLNIVPTDDIWVTANYKETQLRHVQPGAPVTIHIDTYGSDIQGSVESIGGATGSKYALIAPDNATGNYVKVVQRIPVRIRLKTVLADGRPLLPGMSVETSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T6</accession>
    <name>E8X0T6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl oligopeptidase</fullName>
            <ecNumber evidence="4">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3100</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.26" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70120">
        <property type="protein sequence ID" value="ADW70120"/>
        <property type="gene ID" value="AciX9_3100"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3100"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_4_0_0"/>
    <dbReference type="OMA" id="HKAYEDF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234245" evidence="1">
        <location>
            <begin position="24"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="505"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="709" mass="77657" checksum="BCAF677F3C6F4B37" modified="2011-04-05" version="1">MTLRNLARCSVLLVYIMSAGAHAQSPAPQSPQLPEDKYLWLEDVSSARSMDWVNAENTRSSSHFEADPRFAADYADALRVLDDPDKLAMPGLKGDVVYNNWRDKDHPRGLFRRTSLADYLTPTPHWQPVLDVDALNKAESAKWVPRGVTCLYPGDQVCLAGLSNGGEDAVTEREFDLKAAKFVDGGFVLPHSKQSVSWQDKDTLLVAREWGPGTLTNSGYPFVVKRWKRGTPLESAAEIFRGQPTDEVGSSARVMHDASGHRLVVFHRGVTFFTNQTFVETPGGLKQLAIPPKAGLGGMIDGQVLIDTHEDWTTDTGAVIKAGSLAAVKLEDLLRDPAHLKPEIVFTPSAKEFMEGAAPTPHHLLLTTLDNVQGRAYLYSHGPAGWTHTRLAVPENSSVGVVSTDETSSRFVLSVTSFLTPTTLYLGDAATGSLKSIKTAPARFDASRDTVEQLFATSKDGTRVPYFVVHPKDMKLDGSNPTVLTAYGGFEVSETPSYSAITGKLWLEKGGVFVLANIRGGGEFGPAWHEAGLKTKRQVIYDDFAAVGEDLIRRKITSTPHLGIQGGSNGGLLMGVEMTERPDLWGAVIIEVPLLDMMRIEKIAAGASWSGEYGSVSHPDELAFWLAHSPYNQLKPGVKYPEPFIWTTTKDDRVGPQHARKFAAKMAEFHEPFYFYEVIEGGHGSGADSKQTAHTDAMNFVYLKEKLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W5</accession>
    <name>E8X0W5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3137</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581462.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3137"/>
    <dbReference type="EnsemblBacteria" id="ADW70149">
        <property type="protein sequence ID" value="ADW70149"/>
        <property type="gene ID" value="AciX9_3137"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3137"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_2_0"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="20438" checksum="B5F086FF37706E0C" modified="2011-04-05" version="1">MSNTEKQQGPTAYSREVGVDSTIKYMGQVITTLAKATETNGRFSLMEVKVRPGLEPPVHIHEREHELFFVIEGSVRFYTPEKTFDVHAGGVGFLPQGKAHTFACLTDELRALILVGATGVETVGMDGYLLQMGEAARDMDVPDPSTIAPIEDPTEVIKAGAAWGIRFLSPEETKAALPEYPGFGVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X8</accession>
    <name>E8X0X8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3150</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581475.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3150"/>
    <dbReference type="EnsemblBacteria" id="ADW70162">
        <property type="protein sequence ID" value="ADW70162"/>
        <property type="gene ID" value="AciX9_3150"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3150"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142859_0_0_0"/>
    <dbReference type="OMA" id="MNGTHVI"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="14276" checksum="12A06654F8181307" modified="2011-04-05" version="1">MRILQQAIRIYTERNQWETAIQFYQVLLGVQCERRVHIAETNVEAAKVGGVLILAADQKMLDELRLVNAVYYVDSLDESFSWLKTNGAKILHEPQTVTGGRNFTARHPDGLVVEYFEPAKKKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X104</accession>
    <name>E8X104_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0802</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0802"/>
    <dbReference type="EnsemblBacteria" id="ADW67870">
        <property type="protein sequence ID" value="ADW67870"/>
        <property type="gene ID" value="AciX9_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0802"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080791_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="27273" checksum="AB9FA25027DEE832" modified="2011-04-05" version="1">MPGDEAGGHADLWIVREDAEGVGVHAEVGRYLVSDDGIVIDVPGIVLFSYRHGTASLGVQVHPGAEPELVETMLVSTALPAVLWMRGRVVLHAAVAVLPGMREAIAFAGPSGCGKSSLLQQLVRQGARIVAEDACVLSPGELMACGLPGLILMRAASSDELDRRIEVPVALEQQLGSARLGALVVLTDRGEPVRRLRGAAALEALLKNLHRPSVPRLLGQMPGLLPQFALLLRQLPVYSVHRSIGVEELKGLSRIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X127</accession>
    <name>E8X127_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ordered locus">AciX9_0825</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0825"/>
    <dbReference type="EnsemblBacteria" id="ADW67893">
        <property type="protein sequence ID" value="ADW67893"/>
        <property type="gene ID" value="AciX9_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0825"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_2_0_0"/>
    <dbReference type="OMA" id="FFLPDKC"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="42774" checksum="EF18E833757B1517" modified="2011-04-05" version="1">MSVVLIEESPAEAIRQACPLDHYLSQPDHTMDARIAAARAKLGKQALILGHHYQRDEVIRFADFTGDSYKLSKVAAETDAKYILFCGVHFMAESADVLAQPWQTVILPDLNAGCSMADMAEIGQVENCWDSLERLGVGEGLIPLTYMNSAADIKAFCGERNGLVCTSSNAPGAFDWAFARGQRILFLPDQHLGRNTAFAMGIPMDQMVVWDPYMINGGVDPARLKAAKVILWKGHCSVHQRFLPQHVDRIRAEEPGMKVIVHPECRWEVCQKADALGSTEKIIEYIEKSPEGSSFAVGTEIHLVNRLAARFAPLGKRVITLDDSGCLCTTMYRISPAHLAWTLENLVEGNVVNRIKVSDDTKHWAKVALDRMLEVRTETAASAPMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D8</accession>
    <name>E8X1D8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2047</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580409.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2047"/>
    <dbReference type="EnsemblBacteria" id="ADW69092">
        <property type="protein sequence ID" value="ADW69092"/>
        <property type="gene ID" value="AciX9_2047"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2047"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_0"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="9">
        <location>
            <begin position="547"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="674" mass="74544" checksum="922E0DE8EB634901" modified="2011-04-05" version="1">MYRTIQQTLLGRIQALLSSKYEITLTQLAVEQPPSIALGELALPVAFELAKRLRKAPRAIAMELAEALNGDLASLPGVASVEVAGAGYLNVRLDRAAAVQSIAADRHADLGGAGFRLIEHTSINPNKAAHIGHLRNAILGDTFQRLLRKDEYKTGYDVGVQNYIDNTGVQVADVVVGFTELLGKDLKSVRELLTELIETNQRIDFYCWDLYARVSQWYTEAGVAAEELQRRKQVRLDTLHALEHGGNDIAVIADIVATDVLRRHLDTMQRLGIEYDFLPRESEILSLHFWDAARKLMIEKGVLYQETEGKNKGCWVMRRAGTDGATEDSGPDEEAKVIVRSNGTVTYVGKDIAYHLWKFGLLEKDFGYVKFHEYATHTCWISTGDMGASDPAHPVFAKADAIYNVIDSSQSDPQNNVIAALRGMGYTDAADRYTHFSYEKVALTPRCAVELGYTISDEDKARPFIEVSGRKGLGVKADDLLDKLTAAAKAELDTRRPELTEDERLVIAGQIAVGALRYFMLRFNRNTIIAFDFKDALSFEGETGPYVQYAIVRAANIFRKSGVTEREALAGLAGADKLTELLGGEEGGGIWETWLAVSRLTAVLDLAINSAEPAHLAKYVFQLAQQFNNFYHRFHILNEMDAERKALLLGTAAVAKREMIRALGFLGIEAPAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q3</accession>
    <name>E8X1Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0905</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0905"/>
    <dbReference type="EnsemblBacteria" id="ADW67972">
        <property type="protein sequence ID" value="ADW67972"/>
        <property type="gene ID" value="AciX9_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0905"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_4_1_0"/>
    <dbReference type="OMA" id="EDHTWVA"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="278" mass="30138" checksum="9BB36CA0BF977227" modified="2011-04-05" version="1">MYRWVYRFRQRFFSANMNSKLFSYAMLSHQGRVRKGNEDTCAAAPEGGVFVVCDGMGGAAAGEVASKLAAETFLAQLAPEGDPKKTPRTSTPDIRLDTAIHAANQAVYQHSRTFPELHGMGTTLVALLLEVAPGNPTGRPSLTLAHVGDSRCYLFRGGELRQLTQDHSLVEEQVRAGQITPYEAEIHPMRNIITRAVGSNAQVEPEIQHLEYESGDLYLLASDGLTRELKDRDIAAAMTRAVSKGNPVNLESLCQVLIAEANDAGGGDNITVLLLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z1</accession>
    <name>E8X1Z1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2108</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580468.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2108"/>
    <dbReference type="EnsemblBacteria" id="ADW69152">
        <property type="protein sequence ID" value="ADW69152"/>
        <property type="gene ID" value="AciX9_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2108"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_1_0_0"/>
    <dbReference type="OMA" id="LIFGLHV"/>
    <dbReference type="OrthoDB" id="991285at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="368" mass="42536" checksum="F2B17127C70FF778" modified="2011-04-05" version="1">MRPTFTLGIEEEYQTVDPESRDLRSHIATEMLEQGKLRLEERVKAELHQSVIEVGTRICNNIEEAREDLYDLRRNMIGLADENGLMLVAGATHPFADWRSQEIYPDPRYDQVVADLQLVARANLIFGLHVHVGIEDREAAIRVMNSLRYFLPHILALSTNSPFWLGMDTGYKSYRAKVFENFPRTNLPDSFASYSEFENYVDLLIKTNCIDNAKKLWWDVRPHPFFDTIEVRICDIPMRAEETIAIAGLIQATACKLWNLHSKNLDYRQYSRALLMENKFRAVRYGLDGKLIDFGKQQELPAKDLIREYLVWVDEVLDELGSRKAVEYIHQMLDQGSGADRQLAVFRETGSLPAVVDYMARETKVGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X246</accession>
    <name>E8X246_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3278</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3278"/>
    <dbReference type="EnsemblBacteria" id="ADW70289">
        <property type="protein sequence ID" value="ADW70289"/>
        <property type="gene ID" value="AciX9_3278"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3278"/>
    <dbReference type="eggNOG" id="ENOG502Z7RK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796291_0_0_0"/>
    <dbReference type="OMA" id="FKSFRHF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234288" evidence="1">
        <location>
            <begin position="29"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="39011" checksum="E86A1672A3581E19" modified="2011-04-05" version="1">MKTSFSSRCVVAVGCVLFSGSFVSTVYAQGCLAAHTSSTIQSCITSGGVNEGAGDGMSFLHKHPLTMEVDWRSFSSFRHFSGEKENFARAAAGLDIENHQNIYSISLDMQVTPRWSVNAFVPVLQGTRDQKYAPVGKFDIAGIGDMIVGVQGWVLKPPAENGGNIAFSLGLKLPTGLNNGMGTAKLANGMVQKVVADQSLQPGDGTWGFTVGAQAYKQTYFHTVGYFQGSWLFNPEDTNGVPTFRASKLEAVMSATDQYLFRAGLSRHVPRVHGLAASFGGRMEGIPVRDAFGKSDGFRRPGYIISIEPAVQYQHHHDMISLTAPWAIQRNRRASVTDLASGTHGDAAFADYAIILSASHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X269</accession>
    <name>E8X269_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3301</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581624.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3301"/>
    <dbReference type="EnsemblBacteria" id="ADW70312">
        <property type="protein sequence ID" value="ADW70312"/>
        <property type="gene ID" value="AciX9_3301"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3301"/>
    <dbReference type="eggNOG" id="ENOG5030YF2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376569_0_0_0"/>
    <dbReference type="OrthoDB" id="1194038at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="23584" checksum="BABF83D1BB095074" modified="2011-04-05" version="1">MAKQEFELAHRLSLLQSKFRAAVPVVDYMPTIIEMPPRHLDRKSAWEGLESILLDIIRRFELKTDRCLEFGVEFGYSTVALSSFFKSVRGVDTFQGDRHTTIIRDTYQEALENVSPYDNIELIRSDYQSYVKTDSSTYDLIHVDIIHTFADTYACGLWSAEHSKCTIFHDTESFPQVKQAVSEIARKTGKTFYNFPECYGLGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X284</accession>
    <name>E8X284_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579340.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0949"/>
    <dbReference type="EnsemblBacteria" id="ADW68016">
        <property type="protein sequence ID" value="ADW68016"/>
        <property type="gene ID" value="AciX9_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0949"/>
    <dbReference type="eggNOG" id="ENOG50333TN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336975_0_0_0"/>
    <dbReference type="OMA" id="PTLHMEA"/>
    <dbReference type="OrthoDB" id="1783399at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="223" mass="22849" checksum="3637FC5BAFE9EDCE" modified="2011-04-05" version="1">MKLGTEDKKKLYLVSGVGAVALLCLYPLYNELFGGPSGPPPVTAPVIKDVTPAGSSSSSTVAPGKAVSAPPGFAVGGKIAQKVGTGGGQLDPTLHMEAMHITEALVYTGTGRNIFAAGPSQMEIAAIAKAKAPARPIPVAIAAARPAEPTGPPPPPPIDLKFFGTSTAANGTRRALLLHGDDVFLASAGDVVQRRYRVVEIAAKSIIVEDIPNTNKQTLPLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J5</accession>
    <name>E8X2J5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">msrB</name>
        <name evidence="6" type="ordered locus">AciX9_2175</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580535.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2175"/>
    <dbReference type="EnsemblBacteria" id="ADW69219">
        <property type="protein sequence ID" value="ADW69219"/>
        <property type="gene ID" value="AciX9_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2175"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_2_0"/>
    <dbReference type="OMA" id="RTEEHCA"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230599" description="Peptide methionine sulfoxide reductase MsrB" evidence="4">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="5">
        <location>
            <begin position="71"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21279" checksum="4A5932035FC5BACE" modified="2011-04-05" version="1">MIKNLSSQSNSSQRPSRRTFLFAAASVAGVAAWRPSFAFAAGNPPTVTVVQFSDAGKPVGKTAVPRVVRTDAEWKQKLAPISFEVARRAGTERPYSGSTWNNHDKGFYRCICCDNAVFSSETKFESGTGWPSFWQPIAKENIVEINDGSMGMERTAISCRECDAHLGHVFDDGPRPTGLRYCMNSAAMRFVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J9</accession>
    <name>E8X2J9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glucose/galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2179</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intake of glucose and galactose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580539.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2179"/>
    <dbReference type="EnsemblBacteria" id="ADW69223">
        <property type="protein sequence ID" value="ADW69223"/>
        <property type="gene ID" value="AciX9_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2179"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_0"/>
    <dbReference type="OMA" id="TWGFAYG"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005354">
        <property type="term" value="F:galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005964">
        <property type="entry name" value="Glc/Gal_transptr_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01272">
        <property type="entry name" value="gluP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="429" mass="45300" checksum="A528945B36A7F2F8" modified="2011-04-05" version="1">MAAATSLQTGSQTTNTQGSFAVPLTLMVSLYFGIGFITALNDILVPHFKDLFHLSNFLALLVQFAFFGAYFLMSVPSGWIVGRVGYKNGIVLSLATMGCGLLLFLPASILVFYPLFLFALFVVGSGLALLQVAINPYIGALGRPETAAARLNIAGFFNSLAGTSAPKVGAAFIFIAAGASAAQLAASVRTPYMILAALAFFMAILTRFVPLPRLLEPTAEAAAEPLDGSAWQFRHLRLGAVAIFLYVGAEVAIGSLLINYLGQPSMGSMTHAAAARYVSFYWGGAMIGRFIGSFALQKIDAAKALTFVAILAFITVATAVLAHGMVGSMAIVVCGLFNSVMWPCIFPLSVKGLGRFTSQGSGILIMMVVGGAVIPEIQGLLADSFGYQKSFLIVLCCYAYLIYFGLSGHRPQQSVETASQTTIAPPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M2</accession>
    <name>E8X2M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580562.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2202"/>
    <dbReference type="EnsemblBacteria" id="ADW69246">
        <property type="protein sequence ID" value="ADW69246"/>
        <property type="gene ID" value="AciX9_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2202"/>
    <dbReference type="eggNOG" id="ENOG50332NY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148050_0_0_0"/>
    <dbReference type="OMA" id="GLNKFFW"/>
    <dbReference type="OrthoDB" id="1981837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="13818" checksum="9A6CF24142ECFEFD" modified="2011-04-05" version="1">MKIAILIARILLGLVFFASGIVSLLKLGKMGGMPVDATAFMTLMVAHNYTTFVALIMLIGGLLLLVGRFVPIGLVLLGPILVNILLFHILFQVPGIITGLVCTVLEVFLIWAYRFSFRGLFAAAPEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R8</accession>
    <name>E8X2R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3357</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581677.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3357"/>
    <dbReference type="EnsemblBacteria" id="ADW70365">
        <property type="protein sequence ID" value="ADW70365"/>
        <property type="gene ID" value="AciX9_3357"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3357"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229388_0_0_0"/>
    <dbReference type="OMA" id="YKVNSPD"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21990" checksum="CE164704D59F2FB7" modified="2011-04-05" version="1">MPLFPSDLPETIFAHCDGGSRGNPGPSGYGAVITDTGGQKIAELSEFLGIRTNNYAEYSGLLAVLAYAVENKRLSLKVVSDSELMVKQIQGKYKVNSPDLKPLWQEARDRIAKLKSFEISHALRHKNKDADALANQAMDRGMKKGEYKATPTAPQITTREPQKTVASPVALPAMLRGFTKDGSIHLLGGATLPNGIFVKIVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U2</accession>
    <name>E8X2U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3381</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581701.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3381"/>
    <dbReference type="EnsemblBacteria" id="ADW70389">
        <property type="protein sequence ID" value="ADW70389"/>
        <property type="gene ID" value="AciX9_3381"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3381"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_0"/>
    <dbReference type="OMA" id="RVTWERW"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="154"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="586" mass="62226" checksum="8FAC6EAAAB25419F" modified="2011-04-05" version="1">MPSDQNPDETHRLSDGRSDIGDEFSHPERPEERRLGESFADPNAIDDTKLGKAFEKTNSSAKKHHRPVKEVVEAPFKHKSSKKVLYIILACVVIIFIIVLIAGAIPRLAQDKETRKRADDTKNAVPVVEAVRVQTAKSGAGLVIPGTTTPLTEASVYARATGYLTRRYVDIGDHVHKGQLLAVIDAPDLDQQVLQAREQLNQAQAQLAQQKTQLALTEVTVNRYRALVSRGVFSRQDGDQQETNFQAQRANVASADRNVDAFRANLNHAIALQSFERVTSPFDGVVTQRNVDTGAYISTTGSAGNGAPPPAQTPGLTNGSSQQGGSTNTSGTSGSGASLAGPSTGGSQGGPLFSIAQVQRLRILVSVPEGYASMIATGQHTELHFQEFPNNTFYGDVTRTAAAIDQNSRTLLTEVQVDNHDGHLLSGMYAVVTFAQHNGGGPANMQSGPIMVTGDAIAIRNDRPTIAVIDSNNKIHLQPVIIGRDFGAETEIVSGLKSGDLIASIFTDQIAEGATVKPQENKKTEQKAAPTSAPPQNTPPGGSTQYGDPGVTDQDMQGQAAKPGQKQGAKSGKETKAGGPNKGSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U6</accession>
    <name>E8X2U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3386</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581705.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3386"/>
    <dbReference type="EnsemblBacteria" id="ADW70393">
        <property type="protein sequence ID" value="ADW70393"/>
        <property type="gene ID" value="AciX9_3386"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3386"/>
    <dbReference type="eggNOG" id="ENOG502ZV4F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2395590_0_0_0"/>
    <dbReference type="OrthoDB" id="2180747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10144" checksum="816464B6579C1D7A" modified="2011-04-05" version="1">MRVNLLTQNVAPTYPLTSSIPLSLTIRPACGLPGEYAYPTDSTSLMRMLRRKTDLPSTVLKRFEGALQTGTPAKLLGVELSEGVLTEIGYFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X1</accession>
    <name>E8X2X1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1042</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579428.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1042"/>
    <dbReference type="EnsemblBacteria" id="ADW68105">
        <property type="protein sequence ID" value="ADW68105"/>
        <property type="gene ID" value="AciX9_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1042"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_0"/>
    <dbReference type="OMA" id="TREYPPD"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="294"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="47304" checksum="C02DFDF1D7112417" modified="2011-04-05" version="1">MRVGLMTREYPPNVYGGAGVHVEYLSLELAKKIEVEVHCWGTQNEDSGNLHVRGDEPPPQITGDTKAKFKAAIDAFALNLSQMKSLAEIDIVHTHTWYVSMAGFLAKKLYGIPFVLTTHSLEPLRAWKAEQLGSGYALSSWMERTAILDADAIIAVSNGTKADIITAYPNVDPARIHVIYNGIDLNQYQKTPNTEALTKYGVDITKPYVLFVGRITRQKGVTHLVDAIRYLPPGTQVVLCAGAPDTPEIAAEMRAKVEALRRETPGSHPTGKENHTPPGVEPEGHSIATGDPTGTGHNVVWIEQMVTKEEAIQLYSHCAVFACPSVYEPFGIINLEAMACKAPVVATATGGILEVVVEGETGHLVPFKPDPKTTFPIDEDQFARDLAAPIAALLADPARAKKLGEAGRKRVEDHFAWSAIADQTIALYETLIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X338</accession>
    <name>E8X338_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2219</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580578.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2219"/>
    <dbReference type="EnsemblBacteria" id="ADW69262">
        <property type="protein sequence ID" value="ADW69262"/>
        <property type="gene ID" value="AciX9_2219"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2219"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_0"/>
    <dbReference type="OMA" id="GEGNAWR"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="536"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="759" mass="83406" checksum="6F1A6C31B82A1477" modified="2011-04-05" version="1">MRRVVYPLLALISLQANAQKRPITEKDLFSFVWIGDVQLSPTSPTVAFVQTTVSPDHSGYETALYTLDTATPNATPHRVTLGTRDQSPRWSPDGKQLAFIRSVEKDGHPTPPQLYLVSATSPQSPIKLTDLPKGASAPQWAPSGTAIAVESSTPQDQAKARLEATKKSRATGDEAHVSDIRIVNREVYRLNGEGNLDPTFVPQLYLVSLPKADGTQEAPWQLTGGRFGVEEYTWRPGSNWIFYTSTHEDEPYYDATEHNTLYGIEASQSTHPQAQPPAALTAELPLEAHGLALSPDGAHLAFHAEAFPIPPAKPVSHQQSDLFVLDLAWKKNAPTVAGAPRNLTVSKGYEMGSGVGGDNTAPRGGGRPAITWTPDSTHLLDVAGNLGSALLMSIDATTGDMTRLTARKQAVLNFTANSKDLIALVSNPIVIGDLYRIGQPSPEDTTREPIGLQTPLTHVNETLFSQLDLTLPQDIKVTPTVRPMDIPFVTIDTFVQLPPSFPMTKDATGAVIPAKPAHPYPTILNIHGGPHSAYGWVFDHEMLTMAARGYVVVYPNPRGSTTYGQNFANIIESNYPGDDFHDLMDTMDAVVAAGWSDPDKLGVTGGSGGGLLTDWTVTQTNRFKAAVAQRDIVDQAAWWYTADIGEFHQYWMPPAPFDNLEIYKAHSPITFINNIKTPMMFILGDADYRTPPTSGGEEFFRYLKYRKIPTVMVRFPRESHELSRSGEPWHRIERLENITAWFDKFLLNTPEPQYDIPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X387</accession>
    <name>E8X387_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2273</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580627.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2273"/>
    <dbReference type="EnsemblBacteria" id="ADW69311">
        <property type="protein sequence ID" value="ADW69311"/>
        <property type="gene ID" value="AciX9_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2273"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_0"/>
    <dbReference type="OMA" id="HQIEVNF"/>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="12410" checksum="7156442F5CB765A9" modified="2011-04-05" version="1">MQKIEAIIQPSKLDEVKDALIELGVEGMTVLEARGHGRQKGHTEFYRGREYAVDLLPKVKLELVVPDTMVEGAIQAIITAARTGKIGDGKIFVSRIDEAIRIRNDERGEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B4</accession>
    <name>E8X3B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3409</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581727.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3409"/>
    <dbReference type="EnsemblBacteria" id="ADW70415">
        <property type="protein sequence ID" value="ADW70415"/>
        <property type="gene ID" value="AciX9_3409"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3409"/>
    <dbReference type="eggNOG" id="ENOG5033MMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199582_0_0_0"/>
    <dbReference type="OMA" id="CDNPLDI"/>
    <dbReference type="OrthoDB" id="2076643at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7331" checksum="D4F174DCC539B73F" modified="2011-04-05" version="1">MAIVCPECDNPLDIDVDMTDEGEVITCDECGTELEVVTLDPLHVAPVDAEGYDDEDLTRDSGEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3G0</accession>
    <name>E8X3G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3456</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3456"/>
    <dbReference type="EnsemblBacteria" id="ADW70461">
        <property type="protein sequence ID" value="ADW70461"/>
        <property type="gene ID" value="AciX9_3456"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3456"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_1_0_0"/>
    <dbReference type="OMA" id="TEIGYYE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21153" checksum="8E10451DEE1CD5D2" modified="2011-04-05" version="1">MTSGPGSPTLEDVLITPFDLQKEPLVFTQTIAPGTIEYAADTSQIGPLPVEGKADLIVEHRGPSEEVEDIRVRASYDGRFEVLCARCLDPVDVPLKGSFDLLFRPEEADAESGERAITEDETEIGYYGKNGLLLEDVVREQVLLTLPGRTLCTQDCKGLCANCGQNLNTNPCKCAETAVDPRWNALQGLAGSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I1</accession>
    <name>E8X3I1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1109</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1109"/>
    <dbReference type="EnsemblBacteria" id="ADW68172">
        <property type="protein sequence ID" value="ADW68172"/>
        <property type="gene ID" value="AciX9_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1109"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_0"/>
    <dbReference type="OMA" id="LNWMRAM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="29902" checksum="C1886CFFF2358FC9" modified="2011-04-05" version="1">MATVLIEDAGGVRTLTLNRPERRNALTPEMQLELIAAMEAVAKDNSVRVVVLTGAGEGFCGGLDLSVLQGMAGLSAAEYEADARRIARMFRVLYELSVPTIAAVNGHAVAGGTGLATLCDFTLAVPGAKFGYTEVRIGFVPALVSAYLTLQVGEKRARELLLTGRLFGAEEGYRLGLVTEVVAASDMAARVVELCGALVGNSPGSMARTKELLVGSNRAWLDEAIEAAVLMNGRVRETADFKEGIASFLEKRKPVWSVSDIAQVQEQATATASTNTEVLASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q7</accession>
    <name>E8X3Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TonB-dependent receptor, plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2297</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580651.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2297"/>
    <dbReference type="EnsemblBacteria" id="ADW69335">
        <property type="protein sequence ID" value="ADW69335"/>
        <property type="gene ID" value="AciX9_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2297"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370513_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="199" mass="20794" checksum="372F3FEF2FCC917C" modified="2011-04-05" version="1">MLAATSAFAQYDNGSFVGTVHDSTGAVVTGATITVINTETGITVTRTSGSAGEWEVPSLKTGVYRVTISHAGFSDTSASNITLSVGARQRVDLSLPAAGTQETVEVTGVSLQVETESSERGQTITGYQSEALPLVSRNYSDLLGLVTGSRQAPSAATTSSINSLVRAGSYNINGEPSMFNNFLLDGLDRLSITHKLRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T1</accession>
    <name>E8X3T1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2322</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580675.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2322"/>
    <dbReference type="EnsemblBacteria" id="ADW69359">
        <property type="protein sequence ID" value="ADW69359"/>
        <property type="gene ID" value="AciX9_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2322"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035908_0_0_0"/>
    <dbReference type="OMA" id="KMYGPEC"/>
    <dbReference type="OrthoDB" id="663130at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="478" mass="52813" checksum="B3F9385E09131389" modified="2011-04-05" version="1">MLKPKPIDRRDALKRIGGGFAFMSFASMLGEQIAQAETAAPVNPGPDQYMLKDPKFKPKAKHVIFLFMNGGLSHIDSFDPKPMLTKFDGQPMPGGDLGHERKTGKLMKSPFEFKKYGKSGIEVSELFPNVGECIDDICVVRSVFTEIPNHEPALIMMNTGANVAGRPSMGSWLTYGLGTINKDLPGFVVLCPQVPTTVGPPLWSSAFLPPIHQATYVSSDTKQKDFDPYKLIPDIHNERFDMKAQRQELDLIKKLDDMNMAENQSTPQLEATIGSMETAYRMQTEAPEVFDVRKESAATIKMYGEGSTARGCLTAARLIEKGVRVVQVYYSQGDPWDHHADILMHRKNAKDSDQPFAALVKDLKARGLFDETIIVCGSEFGRTPVVELGGAGTHNGRDHNPHGFTMWLAGGGIKGGMTYGATDDFGWKVVDKPVHVHDIHATILYLMGIEHTKLTYRSSGRDYRLTDVSGKVIHDIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X404</accession>
    <name>E8X404_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3507</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581823.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3507"/>
    <dbReference type="EnsemblBacteria" id="ADW70512">
        <property type="protein sequence ID" value="ADW70512"/>
        <property type="gene ID" value="AciX9_3507"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3507"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_3_3_0"/>
    <dbReference type="OMA" id="CVSYICH"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10692" checksum="B3EFD388AC1E01DE" modified="2011-04-05" version="1">MLSFTVRMRFDEADHEAIEGALKALTTGSRAEPGCVSYICHFLESDPNTVFIYEQYKDSAALDEHKATSHFSEFAVGVLYQRMKERVVENLTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X417</accession>
    <name>E8X417_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581836.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3520"/>
    <dbReference type="EnsemblBacteria" id="ADW70525">
        <property type="protein sequence ID" value="ADW70525"/>
        <property type="gene ID" value="AciX9_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3520"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648798_0_0_0"/>
    <dbReference type="OMA" id="IPYLNLY"/>
    <dbReference type="OrthoDB" id="1479128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="420" mass="43779" checksum="C15EC87F5AF31D57" modified="2011-04-05" version="1">MAALSLNLAGWWRHRAPGPDLRRILLAAILYNVGLSAYLFLFSLFLMDHGFTERTLGLVATAMVLGTMAGTLPIGLLAARFGLSRVVLTCLLLVGPIFIARTAFLTLPIQLALAFLSGMVVCGWVVGLSPLVAGVSTEAKRPFAFSLLFSVAILSCGAGGFLGGHLPGWLARVVHSPSQSAVLIAGSLLAMTAAWPIARLTPALRHALAPSPTRSILPPTHLLRFFAAGSFYAAAIGCFTPFVGVFFVHRLGFGLGPLGTLFSVLQALEALAVLAMPFLLRRLSLPSGILATQLAGACSLTLLAGSHGGLQSAIGLCGYLAAFHMSEPFFQTLLMNRAAPQERSSASAAWFLANSLAQAAAATLGGAIIARYGYPVLFAGAIAAMIAAAACLRLALQPTQQGRPEAPSPMPEIEVNPIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X419</accession>
    <name>E8X419_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3522</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3522"/>
    <dbReference type="EnsemblBacteria" id="ADW70527">
        <property type="protein sequence ID" value="ADW70527"/>
        <property type="gene ID" value="AciX9_3522"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3522"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420210_0_0_0"/>
    <dbReference type="OMA" id="YPHAHYL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="SSF49742"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230657" evidence="3">
        <location>
            <begin position="18"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="652" mass="70653" checksum="61E7D1F596E1AE26" modified="2011-04-05" version="1">MRFVGSLMLWLAGVAGAQSAPTWRHDVAPVLYQSCTGCHHTGGSGPFALMTYAEAKRFASVIDTAVTTRYMPPWLPEEGHGRFQGDRHLPAETVALLHRWIAAGAIEGAGPVAKAPVYTSAWQLGEPDLIVETQTAVSVPASGSDFFTNVILPNPLAGTHWVRAMEIKPGNPQVVHHANVLIDRTASLRRTHPEWRRGVPGMDIEVDSGDDFDPDSHFLFWKPDSTALVEAPGMPWRLDAGNDLVLNLHLKPSGKAETTRARIGLYFTKTPAELHPMLLQLEHDAALNIPAGDASFPVEDALTLPVAVSVLGVYPHAHYLARRMEGWAVTPDGARRDLILIPEWDIDRQSVYRLAEPMKLPGGSVLHMRYVYDNSTGNIHNPHSPPVVVRAGNRSEDEMAHLWVQVLPEVDTLASRQALEGAWMSSVLRKNPGDAIALYNLAALKLSTGAAARAVELYTQLDGLTPGSARVLTALGSALQARGDDTGAKVRYEAALKVDGGYTDAAFDLATLDVRLGDAAGAKPLLVGMLARHPEDAEAHHLLALVYAGGEEFEEALVQLRAWEALAAKDPEPHRALAQVLSQMGRGAEALREQQQVVALALRDANDWNDLGVMEARAGDKVAARRDFLRALEINPGLTEARGNLGHLKPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X425</accession>
    <name>E8X425_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3528</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581844.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3528"/>
    <dbReference type="EnsemblBacteria" id="ADW70533">
        <property type="protein sequence ID" value="ADW70533"/>
        <property type="gene ID" value="AciX9_3528"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3528"/>
    <dbReference type="eggNOG" id="ENOG503404R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147297_0_0_0"/>
    <dbReference type="OMA" id="RLRRWGW"/>
    <dbReference type="OrthoDB" id="2023782at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="119" mass="13347" checksum="4201EEEE4EA4E945" modified="2011-04-05" version="1">MTQPTQPKGQLLPGIAGICIFMLVLTLLNVFGALSNAFGTGRGKYGILALCSLLVIGIFGLLRMRRWGWALVLAGCLLLSFGDFHFFKLAHSLFFLIRGFFMLLFFLYLVRSEVRDRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X437</accession>
    <name>E8X437_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0006</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578426.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0006"/>
    <dbReference type="EnsemblBacteria" id="ADW67097">
        <property type="protein sequence ID" value="ADW67097"/>
        <property type="gene ID" value="AciX9_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0006"/>
    <dbReference type="eggNOG" id="ENOG50335Z3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554221_0_0_0"/>
    <dbReference type="OMA" id="NWHVSKI"/>
    <dbReference type="OrthoDB" id="1366181at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="16383" checksum="86FBFB809C02E1EB" modified="2011-04-05" version="1">MRLGLGAGLLMAGGLLQGAAAQAVPQSITGRWRVERILPTHNVGCWDAERAKTLVGSTLRYEQGRMTWQGGTVEVAEALSRTLSRRKYQDEYSVDLAELGIKAAEVVEIDLQHEDADVTGATTEVPGDTVVMAGPGRIVVSACGVYFLAVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X494</accession>
    <name>E8X494_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0063</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578483.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0063"/>
    <dbReference type="EnsemblBacteria" id="ADW67154">
        <property type="protein sequence ID" value="ADW67154"/>
        <property type="gene ID" value="AciX9_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0063"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972492_0_0_0"/>
    <dbReference type="OMA" id="GKAWDPY"/>
    <dbReference type="OrthoDB" id="1597938at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="31297" checksum="CEDC29B49C5C0FEC" modified="2011-04-05" version="1">MPSTCHELRHVPLFALLDDDELGVLATQVEIRQFAPRQRIYKLGEPGDRAYILLEGGVQVTTIDQDEQEVLVATPEHGEFFGFASMLEQTPHHTSAVATIETTCVELDRNDISVLLTQKPMAGLDMMTVLARQFHASQEIIRLRANRNPNLVIEEEETRGEKIADKVASFGGSWTFIITFAVILITYTTINIILRGKAWDPYPFILLNLFLSMLAAIQAPVIMMSQNRQDKKDRVRSELDFDVNVRAETEIQALSRRVKELHDKLDDVDGLLRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A4</accession>
    <name>E8X4A4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1168</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1168"/>
    <dbReference type="EnsemblBacteria" id="ADW68231">
        <property type="protein sequence ID" value="ADW68231"/>
        <property type="gene ID" value="AciX9_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1168"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_1_0"/>
    <dbReference type="OMA" id="EWPVGSR"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="285" mass="31155" checksum="230AB6D9B996A050" modified="2011-04-05" version="1">MLARKSLQSLHKQRNRETVSTALKGAPIHIVKSPTQDGATNHSQLTMQVVDHVRDLISSGELKPGDRLPPERELARKLKISRSSLRAGIGFLSAMGVLKSRHGAGTFVSSGPPALDSSSLTVLGALHGFLPWQMFEARLVLEANVAALAAERATGEHIAELAEEVAEMYAFMDDPQEYLIHDVRFHRTISRAAGNPILAALMETITASLYDTRRITVDHAVDLKESAEMHREIYRAIRSRNPAAAKRAMEQHLNMARTAQATEPLKDVETPAAPTPTPDTTLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E9</accession>
    <name>E8X4E9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579599.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1213"/>
    <dbReference type="EnsemblBacteria" id="ADW68276">
        <property type="protein sequence ID" value="ADW68276"/>
        <property type="gene ID" value="AciX9_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1213"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_4_1_0"/>
    <dbReference type="OMA" id="AIAKSTM"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13679" checksum="8C13DF08B558DDF2" modified="2011-04-05" version="1">MRPLFHPSVDDVTVEAILHALSDPVRVAIFADIVGQSCSQNCSTFLQVSEKTIPKSTLSQHFKVLREAGIIRGERRGVEMHNTSRCAEIEVRFPGLIAAIVNAHTIQLASVAKAAGTAKKKTSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4I7</accession>
    <name>E8X4I7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2360</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2360"/>
    <dbReference type="EnsemblBacteria" id="ADW69397">
        <property type="protein sequence ID" value="ADW69397"/>
        <property type="gene ID" value="AciX9_2360"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2360"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_0"/>
    <dbReference type="OMA" id="FPMMSKI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234164" description="Glutathione peroxidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="19771" checksum="2F8CF19370949CA0" modified="2011-04-05" version="1">MRKFYVMLMLLLLNGLAVADAGAPVYNFKLNTIEGEPTTLGAYKGKVLLVVNVASACGFTPQYTALETVYEKYKNKGLVIVGVPANNFANQESGTNAEIREFCSGKFHVKFPMMAKVSVKGDDKTPLYQYLTTAPNIGGEIKWNFTKFLIARNGQPIARFEPAVTPDSPQVISAIESALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R2</accession>
    <name>E8X4R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3547</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70551">
        <property type="protein sequence ID" value="ADW70551"/>
        <property type="gene ID" value="AciX9_3547"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3547"/>
    <dbReference type="eggNOG" id="ENOG50335XJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186768_0_0_0"/>
    <dbReference type="OMA" id="IVQTSYL"/>
    <dbReference type="OrthoDB" id="2004624at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10028" checksum="5696C3F77C016DF2" modified="2011-04-05" version="1">MSNPLHGTNAEAAMGPVGPSEMIPEELALEIRRMAHDLSNALEIIVQTSYLLSTAELKEPASDWLSMLDGGVNKALDINQALRTYIKTHTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z0</accession>
    <name>E8X4Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0093</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578511.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0093"/>
    <dbReference type="EnsemblBacteria" id="ADW67182">
        <property type="protein sequence ID" value="ADW67182"/>
        <property type="gene ID" value="AciX9_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0093"/>
    <dbReference type="HOGENOM" id="CLU_2167396_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="11677" checksum="599A129F285C6D85" modified="2011-04-05" version="1">MTLVQLVELIGNVLTQLDRILSDPALPSSNPDWQQLYAMRVQLDGKQKQLVGLSITLDDNSFTSLTSKIADADATLKQQIGDLAKVASTISTAAKIAALADQIISLAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X551</accession>
    <name>E8X551_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="11" type="ordered locus">AciX9_1253</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1253"/>
    <dbReference type="EnsemblBacteria" id="ADW68315">
        <property type="protein sequence ID" value="ADW68315"/>
        <property type="gene ID" value="AciX9_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1253"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_0"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="523" mass="58153" checksum="A27E49739C600ABA" modified="2011-04-05" version="1">MLLGSTGVYSFDNVYFIRRWLRQGDLLVSMESNGNGHSNGNGHHVGNDYVVPVGRAEWIVKRKAEAERTGDTNMSQMHFARKGLITEEMLYVATKEKISAELVRSEIAKGTMIIPANINHPELEPMAIGVESLCKINANIGNSALTSNVDEELRKLHTAVHYGADTVMDLSTGGDIPMIREAILRHSPVPIGTVPLYEALNRVKRLEDLNIDVYLEVIEEQAQQGVDYFTIHAGVLVQYIPLVAKRITGIVSRGGAIMAQWMTHHHKQNFLYENFDRITKVMAKYDVSYSLGDGLRPGCLADASDEAQFAELKTLGDLTRQAWKSDVQVMIEGPGHIPMDQIKLQVDKEVELCDGAPFYVLGPLVTDIAPGYDHITSAIGAAMIGWHGAAMLCYVTPKEHLGLPNEKDVKDGIIAYKIAAHAADVARHRPGARDRDDAISHARYTFDWDKQFALSLDPETARSMHDETLPDDYYKEAAFCSMCGPKFCSMNWSSKVDKFNESEFGLKKPDLTQIMTEQMALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X580</accession>
    <name>E8X580_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ordered locus">AciX9_1282</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579667.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1282"/>
    <dbReference type="EnsemblBacteria" id="ADW68344">
        <property type="protein sequence ID" value="ADW68344"/>
        <property type="gene ID" value="AciX9_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1282"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_0"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="20441" checksum="09DF3B9D042B626C" modified="2011-04-05" version="1">MSEEMIEQDLAANEASGPVMVEDAMEQSAAELTQVKGERDQLLDRLARLQAEFDNARKREIKERQDAREYTIGSTVEPFLSVMDNFQLALKAQGSADQLRMGVELILKQMEEALKSLQVTPVESVGTQFDPRVHEALGSVETVEFPDHQVLEEIRRGYKIREKLLRPAMVKIAENKAVVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H0</accession>
    <name>E8X5H0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580833.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2484"/>
    <dbReference type="EnsemblBacteria" id="ADW69517">
        <property type="protein sequence ID" value="ADW69517"/>
        <property type="gene ID" value="AciX9_2484"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2484"/>
    <dbReference type="eggNOG" id="COG5207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163943_1_0_0"/>
    <dbReference type="OMA" id="WGWCYVD"/>
    <dbReference type="OrthoDB" id="1674309at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9362" checksum="0AED3ABC8352E712" modified="2011-04-05" version="1">MTCTHMEGLGPVTRSGKGCVECLEQGMRWVHLRECLVCGHVGCCDSSVGKHATKHFKGTGHPVMKSIEPGERWGWCYVDQAMVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I0</accession>
    <name>E8X5I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2495</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580843.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2495"/>
    <dbReference type="EnsemblBacteria" id="ADW69527">
        <property type="protein sequence ID" value="ADW69527"/>
        <property type="gene ID" value="AciX9_2495"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2495"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077340_0_0_0"/>
    <dbReference type="OMA" id="LMTHDRA"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="25691" checksum="F0A94A33172E1BBE" modified="2011-04-05" version="1">MAAGTNRLLEKLPAEYRTTLLARMEAITLPVPVNLYEPGVVPKYAHFMTSGVTSVVTFMEDGNGVEVGLIGREGLVEGMHLLGAGLLPTTGFIQVDGTALRMSFAELRREFQSSEMLRTLILAEVQAQNLVLGQIAACNRLHELEERLARWLLMVSDRLESDHFTLTQEFLAEMIGARRTTVTLAAGSLQRSGLIEYKRGHIKILDREGLESAACECYPIVRDLIETLYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J2</accession>
    <name>E8X5J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3616</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3616"/>
    <dbReference type="EnsemblBacteria" id="ADW70619">
        <property type="protein sequence ID" value="ADW70619"/>
        <property type="gene ID" value="AciX9_3616"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3616"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_0"/>
    <dbReference type="OMA" id="HIMEYAS"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="302"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="564" mass="60973" checksum="CBFDC7C06B8AFC72" modified="2011-04-05" version="1">MAAAVCLGGVAVAMGQPQPASENVDLAMYSRIRDEGFNRSHVMEYGSALFDDIGPRLTGSPAMKKANEWTRQQLTAMGCANAHLESWGEFGMGWTQKGASLEMMKPGPAVFLAQATPWSPSLGKAVTAEVVRVPSLKTQKDLDEWKGKLAGKVILYGDAPKINPDPKPLLEHYDVAKLAGLGQYPLDGDMSEQGVLQSTDMSFWRGLFGDLAFKEKVAKFFAAEKAVAVLTPGGSGGVIEDDTLGTFGWYVYRADHKQAIPEMVIANEAFGRMSRLLAAKVPVTVKAEIETEFSGDHEQGYNTIAEIPGSDPALKDQVVMVGGHLDSWIAGTGATDNGAGTIVAMEAMRILTSLGVKPRRTIRIGLWSGEEQGIFGSSGYVSKHFAEFKFSKDPKDADVPEFLQTMAAAPVMKPEAAQLSGYFNMDNGTGKLLGIYAEGNAGIGSIFQQWMAPLKDLGMTTVSLRNTGSTDHVPFQMAGLPGFQFIQDPRDYETRTHHTNQDVYERLSPSDLKQASVIEAIFLYNTAMRDAMLPRPELPMAGEAKPLEGLFLDATKDGKKGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z1</accession>
    <name>E8X5Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4095</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572787.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70875">
        <property type="protein sequence ID" value="ADW70875"/>
        <property type="gene ID" value="AciX9_4095"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4095"/>
    <dbReference type="HOGENOM" id="CLU_645231_0_0_0"/>
    <dbReference type="OMA" id="NGTHERI"/>
    <dbReference type="OrthoDB" id="1456477at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="46988" checksum="45B4EDF5661A3945" modified="2011-04-05" version="1">MDKVLFLSGTTRGGTLEGIGRAFAPVLKELDMELVEVSLHHLDPLLQLLKSGALERFKFVLSCVGMGMDLTTNQGGAATNLWQEIGVPFITLHGDSPAYFFDRHVVPSNNFISLYAFAEHRELRARLPFRKGPTGILAPIVLDELPLQKLDFEAKRNGPLLFLKNGKNPNDIRDSWTESLDLPLLQSLLELADELENDLDAPQSNQIDDLVTRYFEDRGFDLLQMVKLRLFFIAQLDDYLRAVKATRMVSALMDLPVQIRGNNWHHLDFTGKKATYIDDCNYVDSIGLIRQSLGLIDMSPNTASMPHDRVLRAYGAHTLCLCNASQSFLDPLPFSDKLTYSFEKDRLCDTVSSILRKPARIIEMGITVAETFRRLHPPEDSFKAMIQYASFARLDQSRERVPGLQDFFVWPPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X661</accession>
    <name>E8X661_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4165</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572857.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70945">
        <property type="protein sequence ID" value="ADW70945"/>
        <property type="gene ID" value="AciX9_4165"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4165"/>
    <dbReference type="HOGENOM" id="CLU_497621_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="547" mass="60356" checksum="32167216872F41BA" modified="2011-04-05" version="1">MILRTQAGDLITLAEPIGKGGEATIHALKGHPRTAAKIYSHPTPERLEKLRAMLAHPPHDPMRSAGHVSICWPQDVLFNAAGQGIGFTMPRLDLSRNRELFKLYNPASRTLEAPNFTWSYLLRTAENIASVVDSLHAAHYVIGDINESNFFVSDQALVTLVDCDSMQAGPFRCTVAKPEYLAPELHGLDLTRVDRAPAHDDFALAVLIFLLVMEGVHPYSGIWQARGEAPSLHLRIANNDYPYAPTIDQRILPMPSAPPFDMLPPTLQGLFFRAFIQGHTHPASRPAPKEWQQALRDLGQSLSTCTVNPRHEFSPHLKACPWCARTILLRGLDPYPTLKPVSKSPTQTPLRPNTFTPTVPKRTRPPIPITRPTLPPPQPRSTRRIGLSIVFASIVSAAVTLWLAFNLLANLLLDFAAAACLLAALFGLLLNLRRFRLIRAFIDLCLALYTLAAIIRPPAIPAFILIPLSALATYFAARSLLLQLRPRMELQTQKSRVLAAESLLIVALVIPPTATLALAQLTATHAQFLKAQSKAAHTWLTQSLEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A2</accession>
    <name>E8X6A2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4208</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70986">
        <property type="protein sequence ID" value="ADW70986"/>
        <property type="gene ID" value="AciX9_4208"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4208"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="FFPGNYT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234436" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1153" mass="123423" checksum="5D14D10CEE29E13A" modified="2011-04-05" version="1">MALAFSTAPILAAALLTPSAMAQLTTADILGTVTDATGAVIPNATVVLTNVETHDQRTATSNGSGDYQFTLLPVGRYTVTTKSSGFKTATTNNLAVEAGDRARADVHLETGGEEQTVNVEAQTPLLQADNATVSSTVTAKAVQDLPLNGRNFVQLVQIVPGANEGPGNGLVSGGRPDDRRASASFSVNGQDDTLNNFIIDGTDDNERVIGTIGVRPNVEGIQEITVETNSYSAEAGRTAGGVVSIITRSGTNQFHGSAYEFFRNDIFDARNVLQGTGRKPELRQNQFGGSIGGPIFKDRTFFFADYEGLRLVSGVTYTSSVPQIAQYNQINSIGGGTPQQLIAQGNGTQTYALDPIALAYLKLFPAPTNAGVTNNYVVSPSKTQTSNTFDARVDHKFNGNNNLFARYTYNKVDTNTPQALGTQNGLAISGGRYIFAGPATDKAMQYGLGYTHIFSQNLLVDLRAAYTRINNLSLPLNNGTAPDTKLGFGSNMNFNNLSSFLTPIQFGGFSDIGDGAYVPLQDIDNTFQYSGSVSYTKGNHNLKFGAGLIRRQARNVQSAFAAGQYTFGLSTDNVASTTQTQINQLASSLVGAFTGESRNYDLNPPDYRSWEPSFFALDSWKVNPKLTVLYGVRYDVFTPFTEAHNRISNFDFTQASGSTAATVGSALKVAGVNGVDGHAGIKTDYSNFAPRVGFSLSVNPKTVVRGGYGLSFFPGNYTSNADLKNAPFVSVYSPNCSQALTALRIQTNTTAAGTPGTTANPTAAASFNNHCFTPGTTTISPTYDGTSNFAAGLPLPAAQTLNSNSLSFVAENPNFRSALIQQFNLQVEEQFGSNVFTVGYVGNLGQHLAQTINNINSPAPFNPLTAPASAQNLRLQTQLPNLGGVGWLSSGGYSNYNSLQTSFQRRFTKGLAFDANYTYAKALSTNTGFSQEGNQGWSNGDPTRINAIDYGVAENDIEHRFALSVNYELQYGKNFTGLKRLALGGWQANTILVWQSGKPFSILNGGQNDFTLLPSGAAGSVYGNRATPINGGGSDRPNKIGNAKGPKTLTQYFNTANYAPQPLGTIGTAQRNSEFGPHFRHIDLSIFKDFHITERVNLEFRAEAFDLTNTPDYYIGNNNVANAQLGSSTFGQVTNYDPNYNPRQLQFALKAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D7</accession>
    <name>E8X6D7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4245</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572933.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71021">
        <property type="protein sequence ID" value="ADW71021"/>
        <property type="gene ID" value="AciX9_4245"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4245"/>
    <dbReference type="HOGENOM" id="CLU_027555_0_0_0"/>
    <dbReference type="OMA" id="FKAHNAH"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="530" mass="55131" checksum="05409155A8D34B3B" modified="2011-04-05" version="1">MDLSGVSLIGDQAGSTGQDVFRGINPQTGASLEPAFYPATATELEQATALAQEASPVFAALDGVTRAKLLRRIADGLTEEGAAIVERAHLESGLPLPRLQGELGRTTGQLKLFADVLEEGSWVDARIDEALPERKPLPRSDIRSMLRPLGPVAVFGASNFPLAFSVAGGDTASALAAGNPVIVKAHPAHPGTSEIVGQVIQKAIQESGLPAGIFSLLFDSGIEVGVALVKHPQIKAVAFTGSALGGQALMRLAAARPEPIPCYAEMGSTNPLFILPGALRERGASLAQGLQGSFTLGSGQFCTKPGVVFVPDSGSESFVESLSGGVASLGGHQMLTNGIAAKYGNAIEQRVSEGKAQLLACAQSLPDNGGAVGAPAIFSVSLEQFMQHPELSEEVFGPTTLLVHYGAEKDLLAAATSLHGHLTATIHGTDEDLAQAQELVAVLETKVGRILFNGYPTGVEVCHAMVHGGPFPATSDGRSTSVGTQAMLRFTRPVCYQDFPNEALPGELRRENVSGIMRLVNGNLTRVAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y8</accession>
    <name>E8X6Y8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3811</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71097">
        <property type="protein sequence ID" value="ADW71097"/>
        <property type="gene ID" value="AciX9_3811"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3811"/>
    <dbReference type="HOGENOM" id="CLU_072626_3_0_0"/>
    <dbReference type="OMA" id="KFHSIVE"/>
    <dbReference type="OrthoDB" id="1614890at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="278" mass="29874" checksum="20D3F25CC88D8AC8" modified="2011-04-05" version="1">MQHARTVKEHPLIDSSKSSKSHMQSGSRRNRAMIASIVIAGSLLATTRIMHARTLLTAADYNASPAEMIEAYRHVEAASVSDAIEQSLHQKSYMSHRMQPIFPTKFAGTALTVKLVKQENHDPDALSGMLKAIDSGGPGSVYVMSVEDGADIAGMGGLMGTAMFSRGFVGAIVDGGVRDLPQLKRIGFPVYSTGSVPSTSVGHYKFSGVNVPVDCDGVKVQPNDIIVADQDGVVVVPREHAADILIAAQKLDNSEHSMYPFIEKFHSIVEAVKQFGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X770</accession>
    <name>E8X770_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4352</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71304">
        <property type="protein sequence ID" value="ADW71304"/>
        <property type="gene ID" value="AciX9_4352"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4352"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="YLAKTHA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="308"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="529" mass="58537" checksum="CB2AA70075368BD9" modified="2011-04-05" version="1">MDGHTEHGAMSSGQTGGKALVVGKGEMAAAIRGFDWDKTELGSLDSWSPTLLSLVNLLVCSPLPATLSWGPDLIFLYNDAAIPTLGPKHPGALGGRYRDVFKEAWSIVRGDLEGCLRDGDTPVRENVMIPLMRGGKLLEKYWTYSLIPVYDGGRIVAVYNPYQETTEGVVALREREAATAQLKQVLEDTSESVMTVDREWRVTYMNPRALQVSAPINPVGLNIWDCYPAFLYENSPWVEHYHRAMDEQVSGSFEAYYSDPINVWVLVQVQPTPNGITIFFRDITKEKQSAAALIQTEKLAAVGRLASSIAHEINNPLEAVTNLLYIARTAIDLPEAIRETLDQADQELGRVALITNQTLRFHRQNTLPQDVTCLDLFSTVLAMYEPKIRNLGIQVEKRKRANKPVRIFEGDIRQVLNNLIGNAIDAMKAGGRLIVRSREGTRWTTGEKGLVLTVADTGGGMSPEVAIRVFEAFYTTKGILGSGLGLWISNEIANRHHGSLRMRSSQGESHGTVFTLFLPFVSRNLIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X772</accession>
    <name>E8X772_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4354</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573025.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71306">
        <property type="protein sequence ID" value="ADW71306"/>
        <property type="gene ID" value="AciX9_4354"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4354"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="OMA" id="EGCLNGH"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="29620" checksum="27C444D88D5ACC75" modified="2011-04-05" version="1">MPEFKPHSFDPVAFLAAAGIGRKIVQIKNKGTLFAQGSAADSVFYLQKGRAKLTVVSQKGKEATITLLGPGDFVGEESISAIAGLRLATATAVSACTVLKIDRIEMIRVVHEEHAFSDLFLAFLLTRSMRTQADLVDQLFNSSEKRLARILLLMAEFGKPGEPEMMLPKISQETLANMIGTTRSRVSFFMNRFRKHGFLEYNGRIHVHKSLLNVVLHDQIFEPNAAKPSLLPIQQHAASKIAKRSNAIVRGIEAPKRLVRGKRDSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X784</accession>
    <name>E8X784_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4366</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573037.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71318">
        <property type="protein sequence ID" value="ADW71318"/>
        <property type="gene ID" value="AciX9_4366"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4366"/>
    <dbReference type="HOGENOM" id="CLU_2879573_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="63" mass="6883" checksum="7D5F9E59053B0A60" modified="2011-04-05" version="1">MAVDHKDIEILSAEPAGKGIIIHFSDGTITLFQTHFLYEVRGDDGNIALADMSEDDLMKGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B0</accession>
    <name>E8X7B0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_4393</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="12 13">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
            <plasmid evidence="13">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573063.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71344">
        <property type="protein sequence ID" value="ADW71344"/>
        <property type="gene ID" value="AciX9_4393"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4393"/>
    <dbReference type="HOGENOM" id="CLU_001600_4_0_0"/>
    <dbReference type="OMA" id="NSWPMGF"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01902">
        <property type="entry name" value="DNApol_error_prone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0614">Plasmid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="11">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119114" checksum="C417A89174616587" modified="2011-04-05" version="1">MTEGYVELHGRSAFSFLEGASMPEAMAEQAASLGMPALGILDRDGLYGAPRLYMTAKKLGLRSHIGAEISTAEFGNQVLPEDWQPHTIPERPVRLSLLCESQTGYRNLSQLITGYKLQQKSKGEGIAPYRMIEERAEGLVCLTGGDEGPLAAALARGGLDEGRKALQSLVRTFGQENVYVELQRHRIREQEARNQAAITLARELHLPLLATNGPNMATAFEREVLDLMTAIRHGCTLDEAGLLLQRNTNRQMIGATEMLTLFRDLPYAVAETVELSSRLQFVMKDMGYQFPLYPIPEDETMDTFLHKRTMEGVANRYGCKTSVKLRKKAERQVERELALIAKLGLAGYFLIVWDIVEFCRKNGMLVQGRGSAANSAVCYSLGITAVDPVGMDLLFERFLSEVRGEWPDIDLDLPSGDDRERAIQYVYQRYGQLGAAMCANVITYRGKSAAGETGKALGFDVETTKRLTQLVGSWEWKGPTDTMEEQFQNAGFDLHHPRIAKYLELSIRMLDLPRHLGQHSGGMIIAQGQLASVVPIEPASMVGRNVIQWDKEDVSDMGLIKVDLLGLGMMAVLKDCVELIPRYYGKKVDIAQIPHDDPKVYESLRRADTVGLFQVESRAQMASLPRNNPDKFYDLVVQVAIIRPGPIVGKMMNPYMERRQGRQEIRYPHPLLEPVLHRTLGVPLFQEQLLRIAMTIANFTGGEAEELRRALGSRRSADKMKALELKLRAGMDANGVGPAAQEEIVQSISSFALYGFPESHAASFALIAYASAWLKFHYLGAFTAAILNNQPMGFYSAAVLVKDAQRHGLRIKPVDVLRSSWSCTLEKEDNGKLSLRLGFRYVRGMREGSAVELEAAREMRPFASIEELARRVPSLTRTDLTTLAEVGALNSIGEGLHRREALWQVERAGRKAGPLLEELDRDEDADSPLRAMEPHERMVADYASTGVTVGRHPMAHCRPQLRAMEIIPARDLSLLRHGVKARIAGCVIARQRPGTAHGFIFLSIEDETGISNAIIDPDLYERNRSLVTYAKFLLIEGALQNVDKVIHIRARHIEQLDVTAAPMQSHDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D6</accession>
    <name>E8X7D6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4422</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573089.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71370">
        <property type="protein sequence ID" value="ADW71370"/>
        <property type="gene ID" value="AciX9_4422"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4422"/>
    <dbReference type="HOGENOM" id="CLU_000288_47_7_0"/>
    <dbReference type="OMA" id="FFDPACE"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="19615" checksum="205789B25F2E37EF" modified="2011-04-05" version="1">MSKLTIPVSTQDHLQGDPHAACSLVEYGDYECPSCGEVQPIIQSLQRHFGNQMSFVFRNFPLREIHPWAEAAAEVAELAGSQGKFWEMHNLLFQHQEDLSEGGLQQLVSRMGLSEKKMQQASMNGMLRKKIEADLAGGIRSGVNGTPTFFLNGDRCDGPTDFNSLASLMDQVLVSNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E6</accession>
    <name>E8X7E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4433</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573099.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71380">
        <property type="protein sequence ID" value="ADW71380"/>
        <property type="gene ID" value="AciX9_4433"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4433"/>
    <dbReference type="HOGENOM" id="CLU_2436672_0_0_0"/>
    <dbReference type="OrthoDB" id="2214173at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="90" mass="10201" checksum="D017793868E7EC7E" modified="2011-04-05" version="1">MFQFSYKLKVSERVKAKCDRHPRYNPEREGRSGIKGGCSTCFSLYDLHQARLSLDSAHHEFLRKAIPWTQVSKPRKKAEGSASSQSSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G4</accession>
    <name>E8X7G4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4452</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573117.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71398">
        <property type="protein sequence ID" value="ADW71398"/>
        <property type="gene ID" value="AciX9_4452"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4452"/>
    <dbReference type="HOGENOM" id="CLU_005379_3_0_0"/>
    <dbReference type="OMA" id="GLPGMCT"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="35180" checksum="646680D8C3281335" modified="2011-04-05" version="1">MSYDLILPFFPEELRTLLLDPSISDLMINGTTGVFADRGGMVERIELKTEYTNERLTAAIVRVARILGQDLTEQNPILNTRMPDGSRVAVVGPPASVNGPTLTIRKFNQWYSSDDLIRAGSLPAEVRDAVVSMIGAKKNGMIAGGTGSGKTTLLKSFLDHIPLTERLCIIEQPAELKIAHPNAVRWEAIEAIPGQVAVTPSELLAAALRHRPDRIIMGEIRNECGYDLLQAMNTGHGGTMSTIHAKSALDALSRLSNLALSAHPNLDHGFIRSETAEAIDFVLYCERDSRGRRRVRELITVDGYTYQTHSFNTTELYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I5</accession>
    <name>E8X7I5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase, LytS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4473</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71419">
        <property type="protein sequence ID" value="ADW71419"/>
        <property type="gene ID" value="AciX9_4473"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4473"/>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_0"/>
    <dbReference type="OMA" id="IRVEDNC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="206"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="34605" checksum="EC8547076F1DEE9B" modified="2011-04-05" version="1">MTSLAGPLISLLLSVLAERLLKRGTPREWCFLGGIVLLAGSALWTVDLIVQAQTLPLLSFRMPNKGDLLMARFNWVYCNLLFSLQTVALALLASSKTLLTREKQLAIERAALQQARLTALRYQLNPHFLFNTLNTISSLAADSGAHEAEEMIAGLADFMRASLSSSMDASITLAAELETTQAYLAIESVRFGERLVVEYLCEPDLSDALVPSLILQPLVENAVKYGVARSKEAVHVRIAARANQKELILTVEDDGCCAPGKLAKAGTGVGLKNVAERLDALHGKEAIMRTEQRTRGFLAELRMPLNISLSYNVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q6</accession>
    <name>E8X7Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4559</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4559"/>
    <dbReference type="EnsemblBacteria" id="ADW71490">
        <property type="protein sequence ID" value="ADW71490"/>
        <property type="gene ID" value="AciX9_4559"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4559"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905688_0_0_0"/>
    <dbReference type="OMA" id="KGVNMSF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="328" mass="36300" checksum="06BCE98A192215BB" modified="2011-04-05" version="1">MSNLLSIGVLIASYKRPADLLRCLDSLKSQNCTPDDVVVVLRHDDLESHHALDFYQSANLPIRRVAVHTPGLVAARNTGIEASTTDVVAMIDDDTVPQPEWLCRVVAAFAENPSLGGLGGRDRCFVDGAFDDRQRETVGKLQWFGRTIGNHHLGFGSMREVDLLKGANMSYRRKALEDSRCDTRLRGLGAQSSEDISLCVSVKKNGWKLAYDPLALVHHYAGERSEERHYSGVGRITNVTPFRDFNYNEVVGLWGALTPLGRLAFFVWSLLVGTRVAPGLLQAIRFTPTLRGNAWLRFVVAQQGKMGAFRDLTFALFLSKSKGNTHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q8</accession>
    <name>E8X7Q8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4561</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573211.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4561"/>
    <dbReference type="EnsemblBacteria" id="ADW71492">
        <property type="protein sequence ID" value="ADW71492"/>
        <property type="gene ID" value="AciX9_4561"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4561"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_0_0"/>
    <dbReference type="OMA" id="FGEHGNN"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="32980" checksum="B3898243A452C71F" modified="2011-04-05" version="1">MPGILITGSTGQVGGELVRLFRSQNPSLEVHAPDRSQLDLRDPASIRDVVRTLLPQWIINPAAYTAVDRAESDQEDAFAVNAEAPRILGEEAAVIGAPVLHFSTDYVFAGDAERPYEETDLAKPLGVYGLSKLAGERNLAASGAAHLIFRTSWVYGATGKNFLRTILRVARQQPQMRIVADQHGAPTAARDLAQMTATIVAQLEETAGAGDLAEAIRSIQGIYNATNSGDTTWFGFAEEALRLRRAAEPCISFAELIPIPTAEYPTPARRPASSRLSCVKLSRTFVIQMRPWQTALGEVLKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U6</accession>
    <name>E8X7U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyl-accepting chemotaxis protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4600</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573249.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71530">
        <property type="protein sequence ID" value="ADW71530"/>
        <property type="gene ID" value="AciX9_4600"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4600"/>
    <dbReference type="HOGENOM" id="CLU_2649375_0_0_0"/>
    <dbReference type="OrthoDB" id="2159189at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="76" mass="8236" checksum="FF7AC0825FDA1705" modified="2011-04-05" version="1">MRDDELLAIYGATRQLAEGMTARDAELKQTTAALEATIAQVRQLPAMLGQQTSKYIAAGIREVVQGGLQAAYREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U8</accession>
    <name>E8X7U8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71532">
        <property type="protein sequence ID" value="ADW71532"/>
        <property type="gene ID" value="AciX9_4602"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4602"/>
    <dbReference type="HOGENOM" id="CLU_1568543_0_0_0"/>
    <dbReference type="OMA" id="FSWYAMR"/>
    <dbReference type="OrthoDB" id="2101048at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="170" mass="18324" checksum="507A1CA683F6C655" modified="2011-04-05" version="1">MLRNPIRTLVPPWSWKAATFAAAVRGLAFFATNLQAGQREATKALVVEAVFAFVTGGLIGAISQHLRKAEPRWATAGVVCICLPGFMLFAQSGVHRLAHTPHLSGGLVLSFCLSVVSAAFSWYAMRHGAMLGGTDETTVFHDLEALPKILLNFVLVGPDLVASIFRAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X830</accession>
    <name>E8X830_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4685</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71614">
        <property type="protein sequence ID" value="ADW71614"/>
        <property type="gene ID" value="AciX9_4685"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4685"/>
    <dbReference type="HOGENOM" id="CLU_2368928_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10479" checksum="2A2F45FF84932848" modified="2011-04-05" version="1">MCARTIPIGRQHEAGPIKPAEFQGDCFAWGVVCASVPSPHGPRIRPKPNIRDVLPRLKCRVCRLAPHGIYLVAGFHRNFGAGGPDPDWCIPIRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA0</accession>
    <name>E8WVA0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0201"/>
    <dbReference type="EnsemblBacteria" id="ADW67275">
        <property type="protein sequence ID" value="ADW67275"/>
        <property type="gene ID" value="AciX9_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0201"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266463_0_0_0"/>
    <dbReference type="OMA" id="FNIERFY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1139" mass="116298" checksum="40774FD2B15D2C4E" modified="2011-04-05" version="1">MRPPVKNSFRFARLLAAFCLGVFSLVPAFGQSGLLISQIYGGGGNSGASFNADFIELYNPTSAAISTSGLSVQYASAAGNFTQSLTLASASIPSHTYFLVQTTASGTTGAALPTPDTTGIAPNLSATAGKVALVNGTTALSTDTTCALIQADTQILDFVGYGTTASCFKGSGPAPTTANNATSIVRKVAGTNTNDNAADFTTSSPITPHNSGGGVVVPPTVPVVTIHDIQGVKSTTAMTVSPYAGQRVTTSGVVTTLLSNAFFMQSSDATADSNPLTPEGIEVFTSTKPTVLIGNAVTVTGTVQTYPAVTASKTPATEITSPTIVVTAPAVALPTPIILTTSMLTAGGGLYQLTPYEGMRVSVPSMTTISGTNGSITDANEPAEIATSVGYFYAVITGTARPFREPGVDIRDPAVPGLPAGVAKFDDNPERILVDSTIAGGTSLEIPTGAIMANVTGVLDFTFSSDSFYDPSRLILDATYPRTSVTGGMTVQAVTLPASNEFTVASFNIERFYNTSSADDLYYVPAGVNGYNGSSGTAIVSTGQTFISEAADNTPAAYARRLTKLSLAIRTVLNSPDVVTIEEVENQSVANDIAAQINSDAGVTNLYTAFSTDNKTYYTQDGTGISVGFLIKNTVDNLGVTQYGAGETFTPTSGSLTTLNDRPWLVLSAGIKRAAGVKDYPITVVVNHMKALTGQSSATTNSTRLKKELQAEDIAKFIQTQQAAGKHVISGGDFNAFEFSDGYNDTLGTYTNTNVLPATQVLQPGVAGLVTPPLTDLALTIPAAQRWSYVEDGSAQILDHMVVTPELVAAGAHFAYGHLNADFPLTAYNDATTAARNSDHDPAIGYFILPAPVLSATVTPNPATAFAGTTIGATSAGQVFTFTNTGEGPITVTGVTTTGDFAVTSACTAPVAISSTCTANVVFRPTAAGTRTGSVTFATNVSGSTYIVALTGVGINPPDFSVGDASGNATTSVTVVAGNTGTVPLTFTPLFGFSGTVSITCVSTATVAPTGVSCTAPAAFTLTGASTQNITFTTASRLFSRNGGLGFAPDASPLTKVLVLAAAGLLMLLAATSRKLGRAARLGGLLSILTAICFATSGCGGSSGPTVNPNGTPAGTYTYTVTVTSGTVVHKETINLIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD5</accession>
    <name>E8WVD5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1321</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68383">
        <property type="protein sequence ID" value="ADW68383"/>
        <property type="gene ID" value="AciX9_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1321"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_0"/>
    <dbReference type="OMA" id="FVSQGFY"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="21407" checksum="32A422AD140AFA97" modified="2011-04-05" version="1">MLLLMTRVRSDDKRSAILAAATQLIVAQGLSAPTMRIAKEAGIPNGSLFTYFPTKADLFNQLYLELKSEMAVAAIEGVQESEFSREKFFKVWRNWTQWAVSFPDKRKALSQLNVSDAITPETRAAAHKAMRPLGALMEDCRAAGPMSKVPMGFVALLLNSAADATMDFMSQEPKHARKHCMDGFDAVWRMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVE1</accession>
    <name>E8WVE1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1327</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579712.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1327"/>
    <dbReference type="EnsemblBacteria" id="ADW68389">
        <property type="protein sequence ID" value="ADW68389"/>
        <property type="gene ID" value="AciX9_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1327"/>
    <dbReference type="eggNOG" id="ENOG5032XB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335958_0_0_0"/>
    <dbReference type="OrthoDB" id="1712703at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234077" evidence="2">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="21647" checksum="6C58C1F1E653A9B1" modified="2011-04-05" version="1">MLFHRYATCTFALTLALSALAPVAHGQDNARRGRKYKAPPATSHIEVQVTKGSNQKPVANAAVIFHSIKDGKDEGNLEVKTNEEGTAIIDIIPTGSNVDVQVIADGLATFAQQYVVNEPTRQIAVTMLPPRAQISTYVDNSGKASERGWGVQEPAKPSTPSVIQTPKPTNHTSDPNPISPVSPNATPGNTQNGTPGNPSGVPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH9</accession>
    <name>E8WVH9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1367"/>
    <dbReference type="EnsemblBacteria" id="ADW68427">
        <property type="protein sequence ID" value="ADW68427"/>
        <property type="gene ID" value="AciX9_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1367"/>
    <dbReference type="HOGENOM" id="CLU_2569058_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="8662" checksum="324C92ACB492D5D6" modified="2011-04-05" version="1">MAEPASTCSDSECFTPPEQGGQEQPPQLNHPSPNVRKSHKKDMDKLSEMAASVKSAAASAKTPEDAKRLTALSEIMEHPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ6</accession>
    <name>E8WVJ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-oxoisovalerate dehydrogenase, E1 component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1385</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1385"/>
    <dbReference type="EnsemblBacteria" id="ADW68444">
        <property type="protein sequence ID" value="ADW68444"/>
        <property type="gene ID" value="AciX9_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1385"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184590_1_0_0"/>
    <dbReference type="OMA" id="CLTENIF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="9124" checksum="9A4709273110DBDA" modified="2011-04-05" version="1">MKAIRTKRSLYNMEELVFVITPDEEDGGFCAAAVGVPIFTQGDDWLDLCAMVLDATKCYYYDSEPPATVRLMLREQVLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK4</accession>
    <name>E8WVK4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="8">1.4.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2501</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2501"/>
    <dbReference type="EnsemblBacteria" id="ADW69533">
        <property type="protein sequence ID" value="ADW69533"/>
        <property type="gene ID" value="AciX9_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2501"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_3_0"/>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="6">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="7">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="23592" checksum="027AA28898539BF9" modified="2011-04-05" version="1">MPEPNTRCGMTMEQAVDPIDFFNCWMEDAKHSELNDPNAMSLATATPDGLPSVRIVLLKTVDAKGFSFYTNGESRKGRELRANTHAALALHWKSRQRQVRVEGTITELPPEDVDAYFKRRHRMSQIGAWASQQSRPLDSRAALLQSTEEIEKRFPGEVPRPPYWTGFVVKPTSIEFWQEGDYRLHDRIVFTPTPNNSWTKQRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK7</accession>
    <name>E8WVK7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exoribonuclease II</fullName>
            <ecNumber evidence="2">3.1.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2504"/>
    <dbReference type="EnsemblBacteria" id="ADW69536">
        <property type="protein sequence ID" value="ADW69536"/>
        <property type="gene ID" value="AciX9_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2504"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_4_1_0"/>
    <dbReference type="OMA" id="WNAQISL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040596">
        <property type="entry name" value="RNase_II_C_S1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18614">
        <property type="entry name" value="RNase_II_C_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="486" mass="52812" checksum="C771EF896A2A8788" modified="2011-04-05" version="1">MVREGFNLLPLDGEEVEAGEREVEEIRGSFEPMSQKRDMGHPEARDLRGLSWSSIDNDTSRDLDQVEWAERTQAGIRVLVGIADVAAAVGKDTVLDRAAALQTQTVYTAVHNFPMLPNELSTDLTSLNEGQDRRAIVCEFTVTGDGGLVGTALYEAWVRNGAQLAYSTVGPWLEGKARGDGRTDPKILNDAAIQAQLRLQDEAAQLLHRQRVAQGALEFNRVEADPVVIDGKVQSIKAVMRNRASDLIADLMIASNETMARMLRESGRSSIRRVVRSPERWSRIVALVAAKGTALPESPDARALNKFLVAQQASDPVHYPDLSLAIIKLMGPGEYVLAAGGSEEQPGHFGLAALDYTHSTAPNRRFADLVTQRIVKALLRGEGAPYSDEELAGIAAHCNERDAAARKVERAMQKRVAAVALGHLIGHQFTGVITGAKDKGTYIRIFDPPVEGKIVRGFEGLDVGDTATVTLSEADPVHAFIDFTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW8</accession>
    <name>E8WVW8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582036.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3726"/>
    <dbReference type="EnsemblBacteria" id="ADW70727">
        <property type="protein sequence ID" value="ADW70727"/>
        <property type="gene ID" value="AciX9_3726"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3726"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_0"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37284" checksum="A031659518742D9A" modified="2011-04-05" version="1">MATNVAVVGAGAFGRNHLRVYRELELAGASVRLAAVVDQDQTVRDQTAATYNIPAFPSVEEMLASGISLQAASVCVPTIHHAAAAAPLLAAGTDLLIEKPIAATLEEADQINVLAAKHHRIVQVGHLERFNPAVAAARAHLNRPMFFEAHRLSVFTPRSLDVDVVLDLMIHDLDIVLSLVPSAVREVRAVGLPVLSRTVDIANVRIEFENGCIANFTASRVSTERVRKLRFFQPHQYLSLDFARQDLLLIDVTAAAGLTDAQLAAMIEKHSKPELPGEPKHPTAGMNMSKIPVAPGEPLRLELSAFLEAVRTRELPQVDGVAGRKALALALEINAAIAEHTLRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY7</accession>
    <name>E8WVY7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-arabinofuranosidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3746</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3746"/>
    <dbReference type="EnsemblBacteria" id="ADW70746">
        <property type="protein sequence ID" value="ADW70746"/>
        <property type="gene ID" value="AciX9_3746"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3746"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_2_0_0"/>
    <dbReference type="OMA" id="FRWEDSV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230355" evidence="3">
        <location>
            <begin position="26"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="346"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="567" mass="61451" checksum="A75D8A379942A86E" modified="2011-04-05" version="1">MNPDRRQFLRAAALTSSALALRASAGIGQLATSVDAHITILPAEPIGTIAPEIYGHFIEQLGGVIYDGVWVGEKSKIPNHHGVRQAFIDAMRAVKAPVLRWPGGCFADSYDWRDGIGPAEKRPQRTAFWTQEDSNRYGLHEFMTTCRAIGCEPYLAADVRSLPARDFYQWVEYCNAPSTPNLSGSLPGGINALAAERARNGSPEPFNVRYWGVGNEVWGCGGSQTAEEYGGEYRRYTEWIPRYGATDEQRRDSLRLIACGANGDDARWTAGVMKSISEHHKPFGFSTHYYTSGDAKKFAAGDALEFDPPTYYDTLARGAFMERIITDSWSALGETNHGHSVKIIMDEWGAWYSKSTELGPKYNLSQQSTMRDAILSGITLDIFHKHADKVAMANVAQTINCIHSLMLASEDKFTVTPTFHVFKMYMPHQGAQSLRVEFAAASIPNPIARVTPVGGNSADGSIDPASKLAGLSGSASIATTGNGKVMTLTVVNPHLDQPITTEIVIPGVTIASVTGEVLTAPDIHAHNDFTHPNAVHPEPAKLGTPSGGRLIHTFPPASVTALSLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW11</accession>
    <name>E8WW11_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0243</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578645.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0243"/>
    <dbReference type="EnsemblBacteria" id="ADW67317">
        <property type="protein sequence ID" value="ADW67317"/>
        <property type="gene ID" value="AciX9_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0243"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_1_4_0"/>
    <dbReference type="OMA" id="NPGHSWL"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="347" mass="39888" checksum="5A36EE2EAF11F58F" modified="2011-04-05" version="1">MKRIDQLDGVRALAIGAVFLHHAFQVKMLWAGVDLFFILSGFLITGILIGAKEKPLGSYFSHFYERRARRILPPYVVLLIVVSIFFGVEWIRHWYLFFFLMNALVSFHAANLEPLAVLWSLSVEEQFYMVWPFVVYFLDETAIAWAAGGLVVLAPLLRWVFTPHFAEHWQIYMLTPFRMDLMAVGALLAVVWRRRRDLVERFGAWGLAMTVAALGVFGALSRYPWFTTTANTRAANVWVYELTLLASLGVILWALSGRGVGLLRWSPLRYLGRISYMFYLIHVPALKLSERWIGNRYESAGVALAGTLLFSAASWRWYEQPILFWKAKSRVRREAEQDEKAITAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM3</accession>
    <name>E8WWM3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3768</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582076.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3768"/>
    <dbReference type="EnsemblBacteria" id="ADW70768">
        <property type="protein sequence ID" value="ADW70768"/>
        <property type="gene ID" value="AciX9_3768"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3768"/>
    <dbReference type="eggNOG" id="COG5587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_2_0_0"/>
    <dbReference type="OMA" id="YKTHQGA"/>
    <dbReference type="OrthoDB" id="1258218at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="230" mass="26251" checksum="814B5AA05F747CF1" modified="2011-04-05" version="1">MSAHFSPAAFKFLRGLARNNDREWFNERKPVYEQELKAPMLDLINQINEAFVDFAPDFIRPAHKSLMRIYRDIRFAKDKRPYKTNVAAWWARQGLEKTSGGGFYFEINATHITIAAGVYMPEREQLLAIRRHLLDHHEELRGLFSAKKTLALLTPFDGLKLTRAPKGFPADHPALDLILQRQWGVSAQLPADLALTPKLTGEIVKRFKAAAPIVDLLNAPLVRRPSKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR9</accession>
    <name>E8WWR9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578725.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0325"/>
    <dbReference type="EnsemblBacteria" id="ADW67397">
        <property type="protein sequence ID" value="ADW67397"/>
        <property type="gene ID" value="AciX9_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0325"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="MAVTSMG"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="287" mass="30640" checksum="7AF4194F12216D2B" modified="2011-04-05" version="1">MAKVWLITGSGNGLGRDIAEAALAAGDKVVAAARRTEELDPLVAQYGERVKPVTLDVRDETAAKAAVQAAVDTFGRLDVLVNNAGYGQFGPFEQMSGEDFQAVVDTCFYGVVYTTRAALPVMRAQKSGHIFQVSSVGGRMAYAGNSPYHAAKWAVGGFSDAVAMEVAPFGVKVCTLEPGGIRTNWAQRAGENVPELLPEYEASVGPILKLLASVRGRSEGDPKRIADLIVRLAASDKVPVRLVLGVDAEKRVQKVEEARASEAKRFRELTLSTVYPDAEAIPGLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWT6</accession>
    <name>E8WWT6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0342</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0342"/>
    <dbReference type="EnsemblBacteria" id="ADW67414">
        <property type="protein sequence ID" value="ADW67414"/>
        <property type="gene ID" value="AciX9_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0342"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_1_0_0"/>
    <dbReference type="OMA" id="MTWMGMG"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234113" description="DUF305 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="60"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="24748" checksum="A8E7A794FE63915F" modified="2011-04-05" version="1">MALKDFIVMRVWLAGALALCAASCFGQQVPIVQPGAPGQANKMLTPATANGVKRAPSKADVDFMQGMIMHHNQAVEMTELLKVQGKDPEVKGLGLRIDVSQTDEMRYMKQWLTDRDLPLENDPMAGMDMSKNPNMDMSSMAMPAMPGMLTAAQMATLRKAHGADFDHLFLTGMIQHHTGALTMVKELFSNPGAGQDPQLFDFASDVDNTQQAEIDIMRHMLKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX9</accession>
    <name>E8WWX9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1487</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579860.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1487"/>
    <dbReference type="EnsemblBacteria" id="ADW68540">
        <property type="protein sequence ID" value="ADW68540"/>
        <property type="gene ID" value="AciX9_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1487"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_0"/>
    <dbReference type="OMA" id="KHYKMIV"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="275"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="549" mass="58166" checksum="2CC1075AF39842E4" modified="2011-04-05" version="1">MRLETKIAISSGALIFTMLLSAFAASLRLREADQVTVRFGARGGVILQVMSLRSHVGRTVFALESEMLNAEGAASRRAEVEQYQKLRRTHWESVDRSLGRLRGEGGTVDLGGVGEGLGAAVARLPELRRLEEQAETLNDRQTPEARAEAMELLEKQILPLEEDSFRVMTGVAETELESAGREIALLHKVHQVAVWTLWGATILGALLGATLAFVLGKNLTRSIGDLVERANSIAGGDLTGLELEMLTNDQVGTMAEAMNRMQRSLSGIIGTVADTAGSLTGSAASMGSASDQIHRRIDQQSQQTQQAATAMQEMSASIAEVSRHTQSAAETARAAAQTARDGGAIVRQMLESMGSIAGAVSETGVTIGLLGEDSKKISQIVTVIDEIARNTNLLALNAAIEAARAGEQGRGFAVVAGEVRRLAESTAKATGEIAGMIHEVQERTRTAVASMEAGTGTVREGVVTTTQAGEALERIIGMAEQVDRMITQIAIAASQQAAAADQSSASLDFIHTLSHDNLMEMATTAAGIENLRGTAVMLEKQVDRFLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX00</accession>
    <name>E8WX00_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1508</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579880.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1508"/>
    <dbReference type="EnsemblBacteria" id="ADW68561">
        <property type="protein sequence ID" value="ADW68561"/>
        <property type="gene ID" value="AciX9_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1508"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_1_0_0"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="150"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="584" mass="64790" checksum="1FB0AAFD4673F0FB" modified="2011-04-05" version="1">MSETALVFAASDQIGRVVSVDTSRVLINVSDSVLLTSIGVGQLLAIKGTTQQEFLIAITEKVTRTLGLELSPEAETGDDESLSTVPRDLMRAALVGTFRSVEGEKKNTFKRGADSFPQIDRDCYVISGSNLQRFMGILGQEIPEDERLLLGRFVADRSAVAIANGDKFFQRHAAILGSTGSGKSWAVALILERASKLKFPNIIVMDMHGEYAPLADKDKGGFAKRYRIAGPGDLDKPKDDVLFLPYWLLNRDEMLSMILDRSDQNAPNQASRFTSHVRQLKQDFLDSVKKLEVKKTFTVDSPIPYQMKDLLSRLGADNTAKGVSSSTGKPITGDLENKLTRFISRLEAKLEDRRYGFMFTPSIDALNYDWLSQQLVKLLGTSDGAGIKIIDFSEVPSDVLPVVTGTFARLLYDVQFWMKADSRTPVTILCDEAHLYLPVREDADAVQRQALGAFERIAKEGRKYGFSLLVVSQRPSDVSKTILSQCNNFLSLRLTNETDQNVIRRLMPDSLAGLTDILPLLDTGEAVLLGDAVLLPTRIRLDKPVIRPDSSTRDFWIEWSTKKADTDAIVAAVECMRSQTRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX04</accession>
    <name>E8WX04_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1512</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579884.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1512"/>
    <dbReference type="EnsemblBacteria" id="ADW68565">
        <property type="protein sequence ID" value="ADW68565"/>
        <property type="gene ID" value="AciX9_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1512"/>
    <dbReference type="eggNOG" id="ENOG5032TZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075807_0_0_0"/>
    <dbReference type="OMA" id="FAISIMD"/>
    <dbReference type="OrthoDB" id="1448652at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26640" checksum="1B55124083666B08" modified="2011-04-05" version="1">MATMAPVVRPVVTRRYDDPFFVGMSLAILGTVVLGFGPTYFYRGAVFAPLPSALVHVHGAIFSSWVILYVVQTALVAMKKIRWHRTLGTFGAVLAGLMVVLGWAVTITNVRRGHTPPIFTPAEFLVINCWGIVLFAAMVAWAVVKRRDGAAHKRLMLLATIGIMPPAITRFQLMMHWPGFAVPLWMLALCVTVMAFDVWTRRRPHYATVVGTLVTFSVPMTANVLGKTAWLQGIAARLTGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX20</accession>
    <name>E8WX20_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1528</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579900.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68581">
        <property type="protein sequence ID" value="ADW68581"/>
        <property type="gene ID" value="AciX9_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1528"/>
    <dbReference type="HOGENOM" id="CLU_2897881_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="62" mass="7046" checksum="CCC063D78DA837B3" modified="2011-04-05" version="1">MNNAHPSAKQDNLGTPRTKAELLFLMGSMQDLVCHLLMRNQQLRMALQKREFEICTIDDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX62</accession>
    <name>E8WX62_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581019.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2680"/>
    <dbReference type="EnsemblBacteria" id="ADW69704">
        <property type="protein sequence ID" value="ADW69704"/>
        <property type="gene ID" value="AciX9_2680"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2680"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699735_0_0_0"/>
    <dbReference type="OMA" id="EEPYYID"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="28"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="43995" checksum="03F38092BB14F3A8" modified="2011-04-05" version="1">MPKAVIKSFASSDRFLSELRSGSLRPGYVLAGDEAFLYQRCRDGVLDALAPPDQRDFCLHDLDLGETAIFDVLDRAQTPSLMVPFQVIFVRGLKALYGRGSKKEEFAAIDAYFRRPNPQALILFVADHLSIPTDLRRMDMTDKERYDRIRETLGDWCGLVELARVEEGDAARWLMETAAERGARIETDAARELVDALGADMMLIASEFEKLCLYAQGKQLLTLAGKPAVETPAITLGDVETMVLAAKQRSLYELTDAISAKDRPRALGLLHGLLNASDGGEDSAIGHLYMLARTFRQMLIISEKNVRDSRAIWGVLWQGFRMPPFAAEELIKQARRYKSRGDLTRALRLIAKADLEIRSSPPDKRLVLERLVLGLATEAKVNVYEASGQFAMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA3</accession>
    <name>E8WXA3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ordered locus">AciX9_2721</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581060.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2721"/>
    <dbReference type="EnsemblBacteria" id="ADW69745">
        <property type="protein sequence ID" value="ADW69745"/>
        <property type="gene ID" value="AciX9_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2721"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_0"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="32547" checksum="4580D6D07044285F" modified="2011-04-05" version="1">MTPQQHVPVLLEEALEYLNVRPGGVYVDATLGLGGHSSAIAKKLGGQGKLIAFDRDPDAMSKAQARLEALKEELGAEMPTVQFEPRAFSEAGDAIAKGSLDGLLADFGVSSMQLDEAHRGFSFRSDGPLDMRMDTRSGETAGQVVNEEDENELADLIYEFGEERRSRRIARAIVRARPISTTAELARIISAAAPPMKGDKIHPATRTFQAIRMRVNDELGEIQSLLKSAGSLLKPGGRLVMISFHSLEDRLVKDAFRELGRDKKFTVLTKKPVIAAEQESLRNPRSRSAKLRALEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI1</accession>
    <name>E8WXI1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1544</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1544"/>
    <dbReference type="EnsemblBacteria" id="ADW68597">
        <property type="protein sequence ID" value="ADW68597"/>
        <property type="gene ID" value="AciX9_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1544"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068226_5_0_0"/>
    <dbReference type="OMA" id="HLHFVAQ"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="21384" checksum="E4EE84A5BA1721E6" modified="2011-04-05" version="1">MTRGLVRYQENRDFHFVTFSCYERKPLLRENDAYALFERSLETMRLRYEFVVAGYVVMPEHVHLLMNEPKEVKLATALQALKLSVSVQMGRVRFWHKRYYDFNVYTSDKRVEKLRYIHRNPVVRGLVTEPGDWEWSSWRHYLTGERGTVEIQSEWTSGRKERKVVETHVSEARRGAPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM3</accession>
    <name>E8WXM3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1586</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579958.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1586"/>
    <dbReference type="EnsemblBacteria" id="ADW68639">
        <property type="protein sequence ID" value="ADW68639"/>
        <property type="gene ID" value="AciX9_1586"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1586"/>
    <dbReference type="HOGENOM" id="CLU_1072678_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233963" evidence="3">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="259" mass="29249" checksum="B0F86CF61AF1F93E" modified="2011-04-05" version="1">MKKYLWFAVAILLLSGIVTVHHENDSQYAKSINIEETKQPRAKPGAPDAKENVEETEHDSSLWAFGYLVFGWPSGIGVIGLFVTMVAIAEQSYFTRVSAEAALLNVQSVINAERAILLFKAEMDESGEMLTLKIVNYGRVPARKIEISKPIYATMRLADLTAMPPDYGNDLEGIQEWLAPNEAWIVAKIAPKWTRMERFYDATKKNLQMTDVDHITYGQVTYFDGISPKRRHSRYCIAMDDDPYEPISVVGNEAYLECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN6</accession>
    <name>E8WXN6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579971.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1599"/>
    <dbReference type="EnsemblBacteria" id="ADW68652">
        <property type="protein sequence ID" value="ADW68652"/>
        <property type="gene ID" value="AciX9_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1599"/>
    <dbReference type="eggNOG" id="ENOG503311H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688432_0_0_0"/>
    <dbReference type="OMA" id="HTWDPML"/>
    <dbReference type="OrthoDB" id="1165709at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="44752" checksum="1E194D317D9ADB26" modified="2011-04-05" version="1">MRIYSAASQENLRTRDLLKEWVAEGLLTHDQRELFNQDLVPDLSTTNLFLRIVLFFFTLIGIAAIAGLFDVAFLSHASGQLAGVIFLFFASACYAAAETAVSQARFYRHGIEEALAVSSIYLLFLGLDLALNPRSVKSHPFEFLIPATCAILALWIWHRFNLWYTFPAAMILVSLLPAYWTSSSIARPVITAVFYIGALIAVAVIRRRHRLSYLNSTYSLAEAFLWLGIYIALNLQLSATNLLMPWSRMPTRLTQEPASSFYWITWVLIWCLPPIILARGIRQKDRFVMEAGALTLLLTFITNKPYLGWTRHTWDPMLLGIVLTAASYYLRRWLAQGPDGIRHGFTASNLSARDKRHINTGSALLGFVTPQSLTPAPQHHNPDLKSGDGASGGAGASREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ4</accession>
    <name>E8WXQ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2725"/>
    <dbReference type="EnsemblBacteria" id="ADW69749">
        <property type="protein sequence ID" value="ADW69749"/>
        <property type="gene ID" value="AciX9_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2725"/>
    <dbReference type="eggNOG" id="COG1718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075702_0_0_0"/>
    <dbReference type="OMA" id="HGATMIW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="267" mass="29315" checksum="AE4EEC49F0D40658" modified="2011-04-05" version="1">MPETHTLTLMLRTVQATRYVLPLREGGSLPAIVEADDQGLYVVKFRGAGQGALALVAELVAGEIARALGLTVPELVFIEVDPILGRNDPDAEIRYLLKASAGLNLALDYLPGSMMFDPAAGNTASAEIASMAVWFDAFVQNVDRTARNANLLLWHRKLHFIDHGAALFFHHNWPTAPAKAESLFAESQHHVLLPWATEIGAAGTKARGIITSELLQNILSFVPDAWLESEEATASERRTAYVEYLTRRLQAASIFEEEAIHAHQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW3</accession>
    <name>E8WXW3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2785</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581123.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2785"/>
    <dbReference type="EnsemblBacteria" id="ADW69808">
        <property type="protein sequence ID" value="ADW69808"/>
        <property type="gene ID" value="AciX9_2785"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2785"/>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_0"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="29166at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="6">
        <location>
            <begin position="501"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="840" mass="93379" checksum="E31786EDC65D3B40" modified="2011-04-05" version="1">MATKLKKAPEPTQPNTTANPERREYTFDIFRRWGYLQTSLDPLGQYLPGEPFPVPVPEDPDSVQAAAEARKFYCGTIAAEFMHIPSPEKRQWIQDQLEREAPPVDQKGMLTDLIKADLFEQVIQSRYLGTKRFSLEGLTVLIPFLNHTFEISANHGVTRSVFGMSHRGRLNVMTNIVGRNATDIFARFEDVDPRSTMGGGDVKYHQGATGEFISPNGKKVALHLVSNPSHLEAVDPVALGRARARQARLLAEGAANAKEQILPLIIHGDAAFAGQGILAESLNMAVLHGYNVGGTIHVIVNNLLGFTAVPEESNSSRFATDIAKRLPIPIFHVNAEDPDAVLRVAAIAAEYRHKFKSDVVVDLIGYRRHGHSEVDDPTVTSPKRYALIKDLPELYKTYAKRIGVDPTEEAAKIQQHFLEEQKLATKAESKTDLAVLPHYWDNYKGGSLSEADAALKTGIDAAQVTSLTKALCAYPETFHIHPKVKKLYEQRLEMAEDKRQFDYGMAELLAFASLVSAGTPVRLTGQDSQRGTFNQRHSALTDTETETKYIPLEHITPNQARFEVYNTLLSEAAVLGYEYGYSRDYPEALVLWEAQFGDFANGAQIIVDQFISAGEAKWHLLSGLVMLLPHGYEGQGPEHSSARIERYLQLCAQDNMVIAQPSTAAQHFHLLRRQALRSWRKPLIVFTPKSMLRHPDASSTVADFGGTFQNVLPDNGVQNPRRILLCSGKIGHNLRVEREKRQKAGHDANVAIVFLEQLYPWPEAEVQAALDQHRNAEVVYVQEEPANMGARSYVMPHLRRMSRDRAIVNVTRSAGASPATGSAKAHDLEERALIDMAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW4</accession>
    <name>E8WXW4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2786</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581124.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69809">
        <property type="protein sequence ID" value="ADW69809"/>
        <property type="gene ID" value="AciX9_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2786"/>
    <dbReference type="eggNOG" id="ENOG5032UQY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076362_0_0_0"/>
    <dbReference type="OMA" id="THPRREM"/>
    <dbReference type="OrthoDB" id="1547112at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="32907" checksum="3A1B0AA1C4C4872B" modified="2011-04-05" version="1">MVSIGRLGWVGEVGLAAGLAVGVGLGQDVGAAKATPDLPEITGLMHAVEVQQRAAELREKDYLYRQSVRMDDLDGHGGVKKTQAEVADIFWLEGVRVRRVVSKDGKELTGDQAKKESERIDKEVAKAKERRAKGDASGKETDSHGNEEVTVSRMLELGSFGNERRESVNGRDTIMVDFVGNPKAKTRNVGENAIHEMVGTIWVDEADRAIVRIDGHFVNNFKVGGGLLFNVKKDTKFSVTNVKVNDEVWLPKRITGDGEARAMLLFSLKGRLAVEDDGYRKFKATSTILPGVAEVPAVPSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXX4</accession>
    <name>E8WXX4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_0441</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578841.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0441"/>
    <dbReference type="EnsemblBacteria" id="ADW67513">
        <property type="protein sequence ID" value="ADW67513"/>
        <property type="gene ID" value="AciX9_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0441"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_0"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="11">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="9">
        <location>
            <begin position="237"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="10">
        <location>
            <begin position="517"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="846" mass="91404" checksum="D2E8D50D2BD367CA" modified="2011-04-05" version="1">MKWWVAVAGVVGGAVVVAGAWGQRLPGNVRAEHYSLRLAPDIAGATFTGSETIDVVLAQPGATITLNAAELKIGAVTAGGQSGVVSYDVGKEQATFTFAKALPAGWVALEIAYAGVLNDKLRGFYLSKSKTRSYAVTQFESTDARRAFPSFDEPALKAAFDVALTVDGGDTAISNTNIVSDVPAAGGKHTLTFATTPKMSTYLVAFLVGDFACSKGKAEGVPIRVCSTPDKVKLTPFALAAAEHFLTYYDRYFGIKYPMPKLDLIGIPDFEAGAMENFGAITYRETELLVDEKESTITSRKRVAQVVAHEMAHQWFGDMVTMDWWDNLWLNEGFATWMESKAAGEWHPEWHYDEDAADELNSTLNYDSDRTTRAIRAKADTPAEIAEAFDGIAYGKAGAVIGMVEEYVGPEVFRRGVHEYLTAHLYGNATAEDFWGTQTSVSGKPVDRVMRGYIDKPGVPLLTFGERGPGGYPVRQGRFLFGGAVDGDWTVPVCLKSGCELASGSQAVVAAPAGSLFYANAGGKGYYRTAYTEAQVRAITGAVGSLTVAERVGFLGDRWALTRAGQGSVGDYLDLVLAVKKDPSAQVLETALDTLGVIRARIATEDDRTKFDNVVLNQLGSVWQEYAKPGKQEDFERQSIRAELFQALGAAGDPKVLAQAHQLTAELLSGHRPGDDDLVDASVVLSASTGDEAFYDKLQIVAEKADDPGLQSEARETLAQFRNPLLVIRTLEYAVSAKVRNQDAWVLIAVELSQAQTQGIAWQWVQKNWDRVQGQLTTASGGQLISATGAFCTVGQRDEVESFFAAHPVEASERSVAKALDSIDDCVHLRESQEGNLKVWLGKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY04</accession>
    <name>E8WY04_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0471</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0471"/>
    <dbReference type="EnsemblBacteria" id="ADW67543">
        <property type="protein sequence ID" value="ADW67543"/>
        <property type="gene ID" value="AciX9_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0471"/>
    <dbReference type="HOGENOM" id="CLU_3396768_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="31" mass="3506" checksum="AD38935971727BBB" modified="2011-04-05" version="1">MVSGHIIPIFAGFLFVCLLYVIVKRRKKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY10</accession>
    <name>E8WY10_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2235 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578877.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67549">
        <property type="protein sequence ID" value="ADW67549"/>
        <property type="gene ID" value="AciX9_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0477"/>
    <dbReference type="eggNOG" id="COG3673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_6_1_0"/>
    <dbReference type="OMA" id="MIAQCMK"/>
    <dbReference type="OrthoDB" id="348728at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="DUF2235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="DUF2235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2235" evidence="1">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="38715" checksum="6A987EF8C10C88A0" modified="2011-04-05" version="1">MKSIVLCADGTWNTPHGDTSTVTDTNVRKLYCALTNDPTQLKYYDSGVGTDGTPLDHLAGGAMGQGLFQKVQDCYAFLGNVYDPGDRIYLFGFSRGAYTARSLAGMIAAFGVPSINLDNSTVPRIFAAYREPDATKKAALKAALVTAYGLEEVKIQMVGVWDTVGSLGIPGIFFNMFNQKQFGFLDTKLHPSTTQAYHAVSIDERRAQFQPTLWTNADGSYRPNDANLEQVFFPGVHCDVGGSYEDSRLSDIPLSWMMQKAKENGLIFSAEAEKTYLTPGAANATGDPHDEWKILPWGLPEHRTIPPNATISNSVQMRLDGIKDYRPENVTLKDGKLSGYSVAAVLPYTKPGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY17</accession>
    <name>E8WY17_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0484</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578884.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0484"/>
    <dbReference type="EnsemblBacteria" id="ADW67556">
        <property type="protein sequence ID" value="ADW67556"/>
        <property type="gene ID" value="AciX9_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0484"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_1_0"/>
    <dbReference type="OMA" id="FMKFVLA"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="518" mass="58485" checksum="BF230328781EF5DC" modified="2011-04-05" version="1">MLFSSGTFIFLFLPASLIGYQILSRFGRTAMLSWLAMTSLFFYGYWNPAYLLLLLGSIVMNFLFARMLGEGRPDASQSRWLVAAIAANLALLMYYKYLFPLLNFFHAHGIVSHGFQEVMLPLGISFFTFTQIAYLIDLRQMIAKRQGLLSYSVFVTFFPHLIAGPVIHPREMMPQLEGRLRGLKAADLSLGLSWFILGLAKKVLIADRISPLADILFAHPASAGFSLGWLGSVAYAMQLYFDFSGYSDMALGIARMFSIEFPVNFNSPYKAQGIIEFWQRWHMTLSRYLNEYLYTPISRSINGRRMDAGKKVTRKATATLEGFSSMVALPVMTTMFLAGIWHGAGLQFLIFGVLHGTYLTINHAWRIFTPEGHRFHRRVPAPLMILLSFVCFVISLVFFRSANVHDALYILGTMAGAHGRHLSFNSFPYLAEIPSISKFLRSLPSALLALGVCFFIVWGMPNTQEILGQLGPDQKRKPSLLPRLSWKPTTSWSLGLAMIFCIAILLLDASTRFLYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY21</accession>
    <name>E8WY21_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0488</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578888.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0488"/>
    <dbReference type="EnsemblBacteria" id="ADW67560">
        <property type="protein sequence ID" value="ADW67560"/>
        <property type="gene ID" value="AciX9_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0488"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="26219" checksum="727BF5B23F8098B7" modified="2011-04-05" version="1">MANKITLVTGASSDIGQAFIRSLLLQDADAIVLAHSFSGGSKIEGLQTEFGDRVVSLTADFSQASSVLAMADTILAVHGPPSAIVHLPALRLVYERFTKLKWDRLQADLAVQVQSAVLLLQRFLPLMAKMPQARVVFVLSSVVHGMPPKFLSLYTIVKYAQLGLMRALAAEYAATPVRINAISPSMVETQFLQDIAPVAVEMAAAANPLSRNARPDDLLGALHLLLSPGANYMTGVDIPIAGGTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY29</accession>
    <name>E8WY29_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67568">
        <property type="protein sequence ID" value="ADW67568"/>
        <property type="gene ID" value="AciX9_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0496"/>
    <dbReference type="eggNOG" id="ENOG5033GH2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1658355_0_0_0"/>
    <dbReference type="OMA" id="CTMTETA"/>
    <dbReference type="OrthoDB" id="1513850at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17270" checksum="84364082F88A529B" modified="2011-04-05" version="1">MLGCTMTETANKPVARQPVFYVALTFGLVLLGFAARGFYRDIRFVSMAATTQGTVTAVMRRDAGGHNGVSYLPRFAFTDQNGRLFTIVSKSGHNPASFSTGDKVQVLYDAQHPETAKIDSFGEIWTNDCALAFFGLVYAGLTLFALIRSRRSGLKLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY41</accession>
    <name>E8WY41_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate-binding protein of an ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0508</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578908.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0508"/>
    <dbReference type="EnsemblBacteria" id="ADW67580">
        <property type="protein sequence ID" value="ADW67580"/>
        <property type="gene ID" value="AciX9_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0508"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234156" evidence="1">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="50"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="34461" checksum="51F149AE1B84D1EB" modified="2011-04-05" version="1">MPRRLLPIRLAVFITLASSALAQSPSTPPTAGAEGTIRIWGHGHRGQDYILTLLRAWQSAFIQSHPGTRFVDELTGNASGLAGMYTNVADLALLDREASFIEVDAYQQGAGYDPFRIPVAMGAVSTPHHAPAIKIFVNKSNPLTGLTMAQLDGIFDADHRRADHSIRTWGDLGLTGPIASHQIHVYTYPIQSAEIQFFERAALKGSQKFGWGLHLIPTAAQIAAATARDPDGLALTVAPEPALKPLPIDGALPTAAAIQDGSYPLARTIYLYANRKPKSAVPPNVAAFLDFIVSPEGQAIVARTGGYLPLPPDAAAKAREALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY46</accession>
    <name>E8WY46_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS sodium solute transporter superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1620</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579992.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1620"/>
    <dbReference type="EnsemblBacteria" id="ADW68673">
        <property type="protein sequence ID" value="ADW68673"/>
        <property type="gene ID" value="AciX9_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1620"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_9_3_0"/>
    <dbReference type="OMA" id="CWTDLIQ"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="605" mass="65820" checksum="24C7DF1657E00F49" modified="2011-04-05" version="1">MIPQAAHLSPVDWLIMLVYFSFVLGIGFALKRYMRTSNDFFLAGRAIPAWVCGLAFISANLGAQEVIGMGASGAKYGIITSHFYWIGAIPAMVFVGIFMMPFYYGSKARSVPEYLRMRFDEKTRALNAISFAFMTVISSGISMYAMALLIQTLGLFHGIIPDQYIFHVSVILSGLIVLGYIFLGGLTSAIYNEVLQFFLIVAGFAPLVWIGLRNVGGWQGIKQTLPATMTHSWRGMAHASTNSLGVEWVGLAMGLGFVLSFGYWCTDFLVIQRAMAADSEVSARRVPLIAAIPKMFFPFLVILPGLIAVTVTSHMASTPAPSYQSPTTHHSSLPLDEAHPHGIIPEKLNPVTGQPMLSADGTPVYNYDLAIPVMLLRFFPTGILGLGLTALLASFMSGMAGNVTAFNTVWTYDIYQAYINKRGTDEHYLWMGRMATIGGVLLSIGAAYLATSFNNIMDALQLIFSLVNAPLFATFLLGMFWKRTTGHAAFTGLLAGTGAALLHHGLTLPADATPGIHGAWLHLVHTYPSDMAQNFWTAIFAFSVNLIVTAAVSLITEPRREAELVGLVYSLTPKPIETHLTWYQKPATLGAAVLAMLVVLNLIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH2</accession>
    <name>E8WYH2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581193.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2855"/>
    <dbReference type="EnsemblBacteria" id="ADW69878">
        <property type="protein sequence ID" value="ADW69878"/>
        <property type="gene ID" value="AciX9_2855"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2855"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_1_0_0"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="21652" checksum="FAB670AA220AB078" modified="2011-04-05" version="1">MRVIAGKYRSRALTAPEGLEIRPTSDRLRETMFNILAARMELRGCRFADLYAGTGAVGIEAISRGATHCWFGEKAAPALKSLRGNLAKLGVSGTEFTVEEKGAGGLLGRFQKLGLAMDLVFIDPPYEAEGEYSQTLGALGRGNLLAAGGLVIVEFATKGKFKLAERYGALVQTRVYKQGETSLAFYGFPAVDDVADGGNAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK4</accession>
    <name>E8WYK4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall hydrolase/autolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0530</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578930.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0530"/>
    <dbReference type="EnsemblBacteria" id="ADW67602">
        <property type="protein sequence ID" value="ADW67602"/>
        <property type="gene ID" value="AciX9_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0530"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_11_0_0"/>
    <dbReference type="OMA" id="PYRLIID"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234168" evidence="3">
        <location>
            <begin position="26"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="4">
        <location>
            <begin position="649"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="818" mass="85125" checksum="EF81E232C6590DF7" modified="2011-04-05" version="1">MNGFLRFRGLGLVAAVCCSVTVAGARPAPLTKWDRAVADRQAFEGLGAGTRSKLGYNRVMDEFRAIYHSNPADGHAPDAIYAVAELLAEQGRELHDEGSLRAAVAQFEFLRKQYPGSGLRTNALLAEGRIDETDLGDAAGAKERFALVVKEAPRSESAGVARAELVTLRAGAGAGPTHRDTAAMNGARSGSSAAKPEPAVTGLRLTEENARLVEGGDAGSSAGLRNDKPIGVRNDAPKVDSVPVLETHVPEAGHGAPIVPVRKGALAQVTGIRHWSTPTYTRVAIDLGDEVTFEAARVPHPDRIYFDLYGARLAQELVGKSFDVTDDGFLKKIRAAQATGDVTRVVLDVNDVTEYSAFLLPNPYRLIIDIHGGSGGGAGAPAKAKAPVDEVAEVPVAPAAAKTASAAANRSGLPAMAPTDGGDAVRLPGGSGRASLEAHPNGDETAVRMGHTTFSQTPNSSSAPTSAAPAPSSVPAPRTGTVARSTVARPVPNTVAVKAPANATEVAAVSEAPGRVDATSAPTSRPIVANVPVPRDVSLGTNTVGTSTKRSRKAAAGSDLDAAPARAAEKTADGETSLVRALGLKIGRIVIDAGHGGHDSGTLGVDGIQEKDVVLDVALRLGKLLHERLGAEIIYTRSDDTFIPLETRTAIANKAQADLFLSIHANSSQDETARGVETYYLNFTSDPTALDVAARENAVSGQSIHQLSDLVKKITLKDKIAESREFAGDVEGSLYGGLAKGNEGLKNRGVKKAPFVVLIGANMPSVLAEISFVTNGKDAAQLRRPEYRERVAESLYNGVAKYESGLGTKVPVVRASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ5</accession>
    <name>E8WYQ5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ordered locus">AciX9_1692</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580060.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1692"/>
    <dbReference type="EnsemblBacteria" id="ADW68741">
        <property type="protein sequence ID" value="ADW68741"/>
        <property type="gene ID" value="AciX9_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1692"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_0"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="513" mass="54501" checksum="71A1276C345BC36F" modified="2011-04-05" version="1">MDTKLIFAEPAAHQTAMLVIFAVDIAVGKDAEPLPVLLTTSDPITNAAARAIASGEFKGNLGENLLLHAPAGLKAERLLIIGLGKAKTLSVNEIRKAAGAAVRAAKPRGIREISIAFPEDHALSDEHLEELPCTLTARVLVEGAEIAELDWDTYRSDRKDLSVYTLTVVVKAGERSTRQEIQSGFDEGLIVAAAQNFARHLVNEPGNVLTPTVLGARTKAMCDEVGLACEVYSTSKLEELKMGAFAAVAQGSAEPPALIVMTYTPAGPVEPDAPVIGLVGKGITFDTGGISIKPADNMEKMKYDMAGSAAMIGAMRAIAQLKPNLKVISVICSAENMPDGKAFKPGDVVTAMSGKTIEIINTDAEGRLVLADGLHYAKTLGCTHLIDAATLTGACVVALGYLNVGLFSNDDATWEQFMAGVPRSGEKFWRLPCTDDYRDQIKSQIGDIMNTGGRAAGAVTAAMFLKEFAGDTPWIHLDIAGCAWNEEQKPWLPKGPTGIAVRSIVEWVRSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS3</accession>
    <name>E8WYS3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1711</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580078.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1711"/>
    <dbReference type="EnsemblBacteria" id="ADW68759">
        <property type="protein sequence ID" value="ADW68759"/>
        <property type="gene ID" value="AciX9_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1711"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="AFMYMGD"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27881" checksum="200ABD63E02C81D5" modified="2011-04-05" version="1">MGVGIQVENLNAWYGTTHTLQDINLHIPANHATALIGPSGCGKSTFVRCLNRMHETNPIARATGTVKMGDVDIYSQASPVEIRRRVGMVFQRPNPFPTMSIYDNVASGLKLNGFRNKKVLDEVVERSLKQSALWDEVKDDLKKKSGASLSGGQQQRMCIARALAVDPEVLLMDEPASALDPVSTSKIEDLIFQLKSQYTIVIVTHNMQQAARVAENTGFFLNGKMVEFAPTHKIFTNPSDKRTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS7</accession>
    <name>E8WYS7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1715</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1715"/>
    <dbReference type="EnsemblBacteria" id="ADW68763">
        <property type="protein sequence ID" value="ADW68763"/>
        <property type="gene ID" value="AciX9_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1715"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059352_0_0_0"/>
    <dbReference type="OMA" id="GAMDKAN"/>
    <dbReference type="OrthoDB" id="1866960at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="41194" checksum="BDB5977D4F742642" modified="2011-04-05" version="1">MPTPQPHEVPSTPVMHLAFVLTGLGTMLLGPILPLLSQRWHLDDAHTGLLLMAQFAGSFLGGITTSHRLRTGTLLGLAAGAIGFTLFALAPSLPLACIGLVIGGFGVGRVITTINITAGNRFTQNRGSALSRLNFTWSFGALLSPVLAAWLTPHFALSNLLLIFALCFLLLAILLLIELRNNFDLSFRTLSEAEGEESASPGPAQSLPTAIFLYFITLLFLYGGLETCLSAWLTTFALRFGVNSLALSEYTMVLLLSGLTAGRAIATWLLLRMRERTLQRIALILSALLAAALATSRHASVIATLAVLLGIALAPIFPATFALLMAHRPPARKAGVVMAVSGLGAAALPWLMGVISTHAGGLQVALIVPIAVAIVMLALSFLPASAESTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ0</accession>
    <name>E8WYZ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase 15-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2882</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2882"/>
    <dbReference type="EnsemblBacteria" id="ADW69905">
        <property type="protein sequence ID" value="ADW69905"/>
        <property type="gene ID" value="AciX9_2882"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2882"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_0"/>
    <dbReference type="OMA" id="VEWMCVP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="235"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="616" mass="68440" checksum="8EF5E6ADF50E5D26" modified="2011-04-05" version="1">MSDIQKKSKLPLHAAKIEDYALIGDCETAALVSKSGSIDWLCWPSFSSAACFSALLGTADHGFWRIAPTREPKSITRRYLPGTLIVETTFTTPDGVVALIDFMPPRGNNSDVVRILRGVSGKVKMHMDLAVRFDFGRTIPWVTHTDFGLRAIAGMDLVVLRTKVSLKGEEMKTVSDFTIKAGDEIPFTLTYGSAMGKDGNSPTEDPRSFSAFTAFDQTVEFWKEWTARNTFQGEYAEAVERSLITLKALTYKPSGGIVAAPTASLPEKIGGQRNWDYRFCWLRDTSFTLLVLLQAGYAEEAAAWRRWLIRAIAGAPAQIQTIYGICGERQLTEYKADWLPGYENSSPVNIGNAASTQFQLDVFGEVAAALTRTPAAEDDIKVSASAVQAQLIDHLCKIWEEPDDGIWETRGGRKHFTHSKVMAWVALDRSIKHYEQFNGKGDIKRWKKNRDLIHKQVCEKGFNKKLNAFTQSYGSKELDASCLRIGLVGFLPMDDPRIIGTVDAIQKRLMKNGLVERYDTKTSPDGLPPGEGTFLACSFWLVTNLWLIGRHDEARALYDRLLALRNDVGLLSEEYDTIGNRMVGNFPQALSHIALTHAAFAISGAWHPDLPLGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ15</accession>
    <name>E8WZ15_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2907</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2907"/>
    <dbReference type="EnsemblBacteria" id="ADW69930">
        <property type="protein sequence ID" value="ADW69930"/>
        <property type="gene ID" value="AciX9_2907"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2907"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825445_0_0_0"/>
    <dbReference type="OMA" id="HNIVRFP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="191"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="365" mass="40948" checksum="998056570B07316B" modified="2011-04-05" version="1">MTSPTPSPQLETKIEILDLRHFNARQLRPLLEEQAQVWKKRLRWNYEASTELLLKYLDQQILPGFVALLRGRILGYCFCVYEGNKAVIGDIYVLAEAPSRLAVTHTLIRHLLEVLEASPEIDRIESQLLLFEEGQISPAFTSSGFTIYPRLFLECDLPATPIPTPSHDILATANLDLIPWSPNLYQASAELIHASYIGHLDSDINDQYRSLHGSLRFLHNIVRFPGCGIFDPEASWLLRDRATNALAAVILCSRVAPDVAHVTQLCIAGPYRGYGLGKFLLQHTMSRLPSGHYRALTLTVSEANEPALRLYTSAGFHQRLRFEALVLDKTVHPERFKIPTQAEPATEGSGLFAAFSRKKATPARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZM8</accession>
    <name>E8WZM8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2979</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70002">
        <property type="protein sequence ID" value="ADW70002"/>
        <property type="gene ID" value="AciX9_2979"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2979"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_1_2_0"/>
    <dbReference type="OMA" id="TIYTHPL"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="390" mass="44135" checksum="B9330C84662C76C0" modified="2011-04-05" version="1">MLNPKEDMPRFDGQTVPSPITPAKKRSAYLPTLDGWRAIAILAVIFDHDVIHTLGPLSTRPLYEYGNHGVDVFFAISGILICFRLLDEESIFGRIHLKDFYIRRAFRILPPALMYLAVISLFAAFALITVGWHEVVASIFFLRNYPRLTGFNGGPDNWYTSHFWSLALEEQFYLFLPALLILIARRYRAAILAALALLVAIHRVFALHGRAWVLIDLHTDVRIDCLLVPAMFAILAYGPQNRELFKKWLRFWPLLAIALLCILPFGEGTALRATAISWLMPLIVLGSVLNPQTFLGKALEWKPLRYIGRISYSLYLWQQLFFLGHFGPPDSRLSLLQSWPLRLILTFACALASYELLERPLARLGHKLAPSATPGRSDLQSTTEAAPKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP4</accession>
    <name>E8WZP4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC sugar transporter, periplasmic ligand binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2995</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581332.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2995"/>
    <dbReference type="EnsemblBacteria" id="ADW70018">
        <property type="protein sequence ID" value="ADW70018"/>
        <property type="gene ID" value="AciX9_2995"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2995"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_0"/>
    <dbReference type="OMA" id="YEMGRQA"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="328" mass="35337" checksum="72143387A1BC9977" modified="2011-04-05" version="1">MRNRLLALIPAATLLAVIGCQQNSRSDTYYLIAGNLKVPYWKTVNAGFAHAADVYGVTAQLRGPDGNDAKAEADEFHTAVSRHPAGILVSVQDAALMKPEIDAALQQGIPVITVDSDAPLSDRLFFIGTNNLQAGRLGGERLVQKLGGKGNIVFFSIPGQPNLDERLKGYLDVLNEHPQMKVVDTFDIKGDTGVAMDRASQLLGQTGAQKIDAFVCLDSASGKDVAEVLKRGNATDRTLIAMDVDPDTLNLIKSGDIEATVSQKPYTMGYAGLQALVDVHDRLPKPFQTNYQVNAFSPYPIFVDTGTSIVDRSNVDIYLANAAKVQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV1</accession>
    <name>E8WZV1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0692</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579090.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0692"/>
    <dbReference type="EnsemblBacteria" id="ADW67762">
        <property type="protein sequence ID" value="ADW67762"/>
        <property type="gene ID" value="AciX9_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0692"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034186_0_0_0"/>
    <dbReference type="OMA" id="YALWTAT"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230500" evidence="1">
        <location>
            <begin position="21"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="314"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="560" mass="60434" checksum="69F063BF81BBEA83" modified="2011-04-05" version="1">MRALRIATSSLLGFALTAFAQGAEPKPAAPIDFTAAEHTAAADPLLTAMLAELQREQQLLILPGMQRPYFMEYRLDDFASYEAVANYGAVSREQRGHQRIVRVSVRIGDYASDSSTSRGDGTVELAPRDNDPQALHYALWTATDEAYKGALRAYAAKQAALKRFEKAPTAEDFSRIPAVQRIEPLVSLSLDEAAWNKRIAEASGLFLTDPALAAAAPHVQYSSADVRGLAVNRYLVNTEGTVFRHGYASYGANYNVGGQADDGMSLSRANGTAAAKADELESAAAFHKRVVDDVLSYEALRNAPVADAEDFHGPVLFSGDASADVLSRLFLPNVEADRPEMGTTARTVGAYQSSFRARVLPDVLDVTDNPLEATFAGKSLIGAYAIDDEGVPAKPVELVEKGKLENYLIGRTPVRDFPISNGHGRAAPGQPAHSRAGVMIFKSTSPISSAELHQKLIGMAKEQGRDVYEVETMGGELAPRLLYRVHPDGTRQLVRGAIFDELDNRSLRSDIVAAGGDPYVDNMTGPIPETIIAPSLLFGDIGVKRASEEQQKLPYYAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ6</accession>
    <name>E8WZZ6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1846</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580211.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1846"/>
    <dbReference type="EnsemblBacteria" id="ADW68892">
        <property type="protein sequence ID" value="ADW68892"/>
        <property type="gene ID" value="AciX9_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1846"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_2_1_0"/>
    <dbReference type="OMA" id="SQVMDIN"/>
    <dbReference type="OrthoDB" id="2021063at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="36752" checksum="BF2B9E307F486B24" modified="2011-04-05" version="1">MGWMKLSGVLLALGMVGALPGQEGLQRFHEVHRAMGTEFSIDLYARDEEAAGAAAEAAFDEVDRLEELLSNYRPSSELSRIGREAGAGTVTTDPETFRFLERAVFWSKRSDGAFDITVGPLLRAWGFYEHGGRIPSDAELKGLRGTLGWERIRLGAADRSVRFVPGRALDLDPGSIGKGFAVDGVVTVLREAGVRTALISAGGSTVYGMGAPPGTEGWPVTVMDPRVVGRVASTVMLKDMSLSSGACTQKFFIKDGHRYCHIFDPLTMRPVEGVLQTTVVSESATDSDALSTVVFVLPPERARAVLKPFGSVRALIFLNATTPESCISINWPGGVCAPSTTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X008</accession>
    <name>E8X008_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1858</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580223.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1858"/>
    <dbReference type="EnsemblBacteria" id="ADW68904">
        <property type="protein sequence ID" value="ADW68904"/>
        <property type="gene ID" value="AciX9_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1858"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_70_2_0"/>
    <dbReference type="OMA" id="WATGMIE"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="911"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2523"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2599"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2626" mass="282438" checksum="D0ECBD1D6AC9F14E" modified="2011-04-05" version="1">MSDEVMDGIAIIGMAGKFPGAKDVATFWENLLAGKDTVSHFTATELEARDGQSGGEDYVAARGILEDVGMFDAEFFGIAPKEADRMDPQHRIFLEACQQALEDAGYVSQEYAGEIGLFAGCSLNTYLLANLSHDREFLDRLTANYQVGEFQVALGNDKDFLTTRAAYKLDLRGPVVSVQSACATSLVAICQASQALMNYTCDMALAGGASATFPQRRGHIYQDGGMASRDGVCRPFDASATGTVFGHGVGVVVLKRLEDAVRDGDHISAVIRGFAVNNDGSAKAGYMAPGVDGQSRVIAAAQAMAGIEPESVTYIEAHGTGTPLGDPIEIAGLTKAFRLGTDRNNFCSIGTAKGNIGHLDSAAGVAGVIKTAMSLTHRTIPGLAHYEAPNPNIDFAETPFFVSKDARAWTADGPLRAGVSAFGVGGVNAHVVLEEAPGIEKSGESERDQVVCVSARSAAALEAVVAGLAGFFEAGSAVKLADVAYTLSVGRRAYEHRFAFSAANVEGAVSALRSQRKRTAVGKGQRRVAFLFSGQGSQFVGMGRELYAAEPVYRRVVDECCEAVGGALEVDLRELMFAPVSETASATLQQTRYAQPSLFVTELALARLWESWGVTAEAVVGHSLGEYVAATVAGVFTAADAMRLVCLRGRMMQELAAGAMTSVALGEEALGKYVTAGVSIAALNSPRASVLSGSFEAIVGLEAELERDGVGFRRLHTSHAFHSEMMEPMLAGFEAEVAALELKAPAMRFVSSVSGTWITSDQAMSPRYWAEQCRKAVRFGDAVATLLGDGFDVLLEVGPGEALTSLSMHQRGVSEFSAVASLPMPRADRESKPVQAAVAELWSVGVGIDWAAYYANEVRHRVSLPTYPFERKLHWVEPPARTTPEGISKIEATPMNNTAPLAAAMPTAVEARPVRLQKMIAGVFAEMSGIETSAEEMDHPFLELGFDSLFLTQATQSLQRTFGVKLTFRQLMEQYSTIASLAGYLDEILPADAFPAAAPVAVVAPISTAGTVTVTNANTGNTPIERLLSDQLAAMSELFANQLATLRGAAGMAAPAVSAAMVVSKPAVATTSPVPVSNADVKHGSFRPLQAKTSHELDDKQKKYIADLIAKYEAMTPTSKSMTQASRARLADPRAVAGFRPQWKEMVYPLITDRARGSKIWDVDGNEYIDIVNGYGCIMFGHSPEFVVEAAKAQLDKGVAIGPQSALAGEVAALICELTGNERATFCNTGSEAVMAAIRVARTVTGRDKVVYFAGDYHGTFDEVLIRNTPRGSAPVAPGIPLANTTNIIVLEYGTDESLAWIRANAGELAAVLIEPVQTRNPGLQPFDFIREIRTITEKSETVMIIDEVVTGFRLAPGGVQEKYGIRADMCTYGKVIGGGHPIGVLSGKAMYLDALDGGAWQFGDDSGPEVGVTFFAGTFVRHPLALAAARSVLNHLKANGPELQLELNRKTARIAESLDRFFADEGVPCRVHHFASWFYFVFPHDARLGSLFYYAMRAKGIHIQEGYPCFLTTAHTEADLDAVEKAFKDTILEMQTNGAMPRELAEAPVAAGMHPDALSETPARIQLTEPQREVFLAAALSDEANCAFNESLTLRLHGPVRMDDLSFALDAVVARHDALRSTVSVDGESLCFSPAFTGQNEIVDLRLTSAEEQKKLIDERVVSEGKAPFDLHNGPLLRSVCFIASDRDAVLVLTAHHIVLDGWSANQLLEEVGKVYSKGASALTGLAPLLPFSSYAVRESKRQESGEFADNERYWVSKFEGRSPRLDLPTDRTRPVNKTFNGATIEGSLGAQLYADLKKLSAKNGCTLYVTLLSAFQILMHRLSRQDEVVVGISTAGQALFEGASLVGHCVHFLPMLSELKGDETVQQHMKATRTALLDAYDHQEFTYGSLLQKLKFERDPSRLPLIEVQFNLEKVGANVQFDGLTTEIKANAKQFVNTDLFLNVVEMGSDLEFMCDFNSDLFDAATLHRWMGLWAQMLTSETLDATVQVLDLEMLPAAEKALVVSEWNKTDVYFGAFEAMPAAFLNVAAKHPERVAIQCGPQSWSYGELMEYSTILAKRLVREGLKPGGLAGICVERSPEMVGAMLAVMMAGGAYLPLDPRHPRERLSMILGDAGISMLLAGRDSSVETTAPILKITGPQPQGNEALPGTIGSDSLAYVIYTSGSTGVPKGVAIEHGALMNLLRSMEREPGLGSEDVLVAVTTLAFDIAALELLLPLLTGAKLVIATDEQVQDGTMLLRLLESTKATVLQATPGAWRILLDAGWTSALPLKVLCGGEALPRDLAEKLLERSNDVWNVYGPTETTIWSSATKVTHGDGPLHVAPPIANTQFYVLDERQRPVPVGVTGELYIGGDGLARGYWKRPELTAEKFVASPFGEGKIYRTGDVGRWHMDGSIELMGRADFQVKIRGYRIELGDIESALGKHAKVREAIVVQQKIGESGASRLVGFVDAGESAAEPAGLVEELQLLLERSLPEYMIPNAIIALREMPRTPNGKVDRKSLIRHADAEGLGVKSVTREFTAPVTEAEIRLAGIWAEVLALKAVSTTDSIFELGADSLLIFRIAARSQREGLAVTATQIFQHRTIRALCRELEEKAGTATAGRPAARISAASRESYKRPKVQVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X079</accession>
    <name>E8X079_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase of anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581374.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3040"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="ADW70060">
        <property type="protein sequence ID" value="ADW70060"/>
        <property type="gene ID" value="AciX9_3040"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3040"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_0"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="22532" checksum="759AE927444F655E" modified="2011-04-05" version="1">MVFVLDNYDSFTYNLVQYMGELGAEMVIRRNDELTPEEIEALNPERILISPGPCTPEEAGVSIPLLKHFAALQEAGGRRVPILGVCLGHQAIGAAFGGNVVRAKKLMHGKTSEVEHDGRTIFAGIPSTMTCTRYHSLIVAEEGFPDVLEVSARTYGKASPEAVEEDGGQTIMALRHKTLPIEGVQFHPESVLTSHGKQMIENFLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H1</accession>
    <name>E8X0H1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0766</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0766"/>
    <dbReference type="EnsemblBacteria" id="ADW67835">
        <property type="protein sequence ID" value="ADW67835"/>
        <property type="gene ID" value="AciX9_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0766"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_0"/>
    <dbReference type="OMA" id="CRWQFLL"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="228"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="587" mass="65383" checksum="D614D9EC026CC1B1" modified="2011-04-05" version="1">MKNSPIPWPRILQEARSRFNIKHFRPGQKEVLASVFAGHNTLALMPTGAGKSLTYQLPALFLPKPVLVVSPLISLMQDQQDKAEQAHVHVEKLNSANTAKQAAAATKEIDDHVAQLIYVTPERLQDPAFIAELKDAGGISLLVVDEAHTIPQWGHDFRPAFLSIGNARKALGDPPVLALTATATEQVALEILQSLHAEDATRIHTGIERENLFFSVHPTVSNEAKLARITDMLTREQGTGIIYTASVRAADELYQHLTDQGISTAHYHGKMKTRDRELIQQEFMHGTHKVMIATKAFGLGIDKPDIRFVYHYEFPDSLETYYQEAGRAGRDGQPAHAVLLYRLEDRKIQNFFLAGRYPKPHDLEAVYQAIAQGSHEAEETPEQIAAEAEVGKRRTQVILHLLLEAGLIQKEGTTYTLTTAEPPTPEALEELLNTYIERAASDKARLEEMMHYAETPNCRVQIIRAYFGEPEGNPCLRCDNCAHTHEIPHHHALEILGYHKQSREAAEPEKEPSQDVTHVQTPYGEIQTTAPETLLQPTQASPFQKGDEVHHATFGTGKILKIEGETITVDFIKAGTKRLKSDFLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I7</accession>
    <name>E8X0I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0782</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67851">
        <property type="protein sequence ID" value="ADW67851"/>
        <property type="gene ID" value="AciX9_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0782"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1609965_0_0_0"/>
    <dbReference type="OMA" id="HEWKLRS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="19274" checksum="C1A3765280A2F3DD" modified="2011-04-05" version="1">MVGPLTLTTLNYPETVMLPPRTLQGGRIKPKALPIGPLGKPLCRWCELEILAKRRRTFCSDYCVHQHRLRTDPGYLRDQVFARDHGLCALCQADTPAIYAALKRARGASRLAGLSLYGMKTITSRRSLWDADHILPVAEGGGQCDLDNLRTLCLPCHREVTAQLRLRLRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K5</accession>
    <name>E8X0K5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">AciX9_1910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1910"/>
    <dbReference type="EnsemblBacteria" id="ADW68956">
        <property type="protein sequence ID" value="ADW68956"/>
        <property type="gene ID" value="AciX9_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1910"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_0_0"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="46"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="52"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="433" mass="46544" checksum="78A5F60B442F2F67" modified="2011-04-05" version="1">MLLLRKNFSRSSPIATARPFAYRNRALSCDQTSLATLAATHGTPLYVYSQQHILGRLALFQQAFASRPHTICYAVKANSALAILKLLAQNGAGFDIVSGGELARVVKAAKPAVKKTVFAGVGKQIPEIDAALKAGILLFNVESESELALLADRAELLKIPARFSLRVNPDVFAETHPYISTGLSAHKFGIDINAARAIYRKAAKSKYLIPTGVSVHIGSQIRAVDPFGAALDRVTSLIQQLKKDGITLTHIDAGGGLGIEYTDAPFDPAAAVAAYAKQVLEATDHLDLHLLLEPGRFLVAQAGALLTTVVNVKKNGNKTFVITDAGMNDLIRPALYQAHHQILPVRQTSAKSSPVDIVGPVCESGDFFARDRDLPATKPGDLLAILDAGAYGMSLTSNYNTRTRPPEVLVDGAESRLIRRRETIKDLFAPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L7</accession>
    <name>E8X0L7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1922</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1922"/>
    <dbReference type="EnsemblBacteria" id="ADW68968">
        <property type="protein sequence ID" value="ADW68968"/>
        <property type="gene ID" value="AciX9_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1922"/>
    <dbReference type="eggNOG" id="COG4634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156527_1_0_0"/>
    <dbReference type="OMA" id="CIDRKLA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="13016" checksum="A287B156B917F4A6" modified="2011-04-05" version="1">MKVLLDNNMTKELKRGLLDHEVATAYEMGWADLKNGDLLRTAQAASFEVMISADTNIFYQQNNAKRIISLLILDTNRWRFIRPRMAVIHDAFSRATRGSYESMNLLPVSARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N7</accession>
    <name>E8X0N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1942</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580307.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1942"/>
    <dbReference type="EnsemblBacteria" id="ADW68988">
        <property type="protein sequence ID" value="ADW68988"/>
        <property type="gene ID" value="AciX9_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1942"/>
    <dbReference type="HOGENOM" id="CLU_2843703_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="65" mass="7504" checksum="E54546CA68EAF5A4" modified="2011-04-05" version="1">MAAPTPFPTVSEEAEDRFELATDRFLRKWGHLLVKDYPKHDPEFTADFHDFEVESIATHDLANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q9</accession>
    <name>E8X0Q9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage head-tail adaptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1964</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580329.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1964"/>
    <dbReference type="EnsemblBacteria" id="ADW69010">
        <property type="protein sequence ID" value="ADW69010"/>
        <property type="gene ID" value="AciX9_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1964"/>
    <dbReference type="eggNOG" id="COG5614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147810_1_3_0"/>
    <dbReference type="OMA" id="WADIHTI"/>
    <dbReference type="OrthoDB" id="2081290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008767">
        <property type="entry name" value="Phage_SPP1_head-tail_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038666">
        <property type="entry name" value="SSP1_head-tail_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05521">
        <property type="entry name" value="Phage_H_T_join"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01563">
        <property type="entry name" value="gp16_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="116" mass="13344" checksum="C4A2C834D1A2C741" modified="2011-04-05" version="1">MNAGTLNRRIQIQSQSETRDQAGQKSTLWDTTYQCWASIDVQQSQLIYSTAEFIGNTTYRITCRYTSSVVFQPNQRIVYTEPTTGVVHLYEIQAILNDKQANKLFIFMCYELNGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R8</accession>
    <name>E8X0R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1973</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580338.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1973"/>
    <dbReference type="EnsemblBacteria" id="ADW69019">
        <property type="protein sequence ID" value="ADW69019"/>
        <property type="gene ID" value="AciX9_1973"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1973"/>
    <dbReference type="HOGENOM" id="CLU_2093396_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="116" mass="11637" checksum="41DEE37BB42B003C" modified="2011-04-05" version="1">MNVLAILKGVGTEAEKLGTGAVHVVEVIGNGAVCFERLLTDASKLTPEVKAGLTTLIADGEAVATGFISAGSNPANFVADAAEAANLAKFVKDFVAFLPVIKAAAGTVKADLTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V7</accession>
    <name>E8X0V7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3127</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581455.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3127"/>
    <dbReference type="EnsemblBacteria" id="ADW70141">
        <property type="protein sequence ID" value="ADW70141"/>
        <property type="gene ID" value="AciX9_3127"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3127"/>
    <dbReference type="eggNOG" id="COG5517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106738_10_2_0"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18747" checksum="442D21653C9CCBEA" modified="2011-04-05" version="1">MENTKNTELLLQQLLDRQEIQDTISRYSQGQDAHQGEDSNILEQWDNTFAKDGTVDYSAAGGTKGSYRDLAKWMRGDGATPGSMSGFSNWQHMLSLPIVTLTGDTAKARTDFFATHRGKKENNFNVHYNASGAFHDELVRTPEGWRIQFRRLEVYFGDPLQIAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z8</accession>
    <name>E8X0Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581494.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3171"/>
    <dbReference type="EnsemblBacteria" id="ADW70182">
        <property type="protein sequence ID" value="ADW70182"/>
        <property type="gene ID" value="AciX9_3171"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3171"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148789_1_0_0"/>
    <dbReference type="OMA" id="ALMANQH"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="10889" checksum="C321B03BE0392607" modified="2011-04-05" version="1">MAKFALLVELKAKPGKESEVEAFLEKEASLVRKEPGTLSWHAAKVEGEAGVYRVFDTFDDEAAREAHLNGEAGQELVEKAEELFSVAPKVYRLGVVAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z9</accession>
    <name>E8X0Z9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0797</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0797"/>
    <dbReference type="EnsemblBacteria" id="ADW67865">
        <property type="protein sequence ID" value="ADW67865"/>
        <property type="gene ID" value="AciX9_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0797"/>
    <dbReference type="HOGENOM" id="CLU_129168_2_1_0"/>
    <dbReference type="OMA" id="PWESKCL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Transglut_core3" evidence="2">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="16754" checksum="D5057209353E43E4" modified="2011-04-05" version="1">MRRETMPQRRRIGRMWHPARAEAVATVRLIEAWLALILARMGIVFLPYIADWAFRADPGQDAVKGSHPIPPYVFRRVRVAVDRAGRGLPWESKCLAKAFAAKMMLSRQGLHSTIHLGAGQRGGQLHAHAWLIADGTIVVGESGMDTVTPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X142</accession>
    <name>E8X142_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lpxK</name>
        <name evidence="14" type="ordered locus">AciX9_0840</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579233.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0840"/>
    <dbReference type="EnsemblBacteria" id="ADW67908">
        <property type="protein sequence ID" value="ADW67908"/>
        <property type="gene ID" value="AciX9_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0840"/>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038816_6_0_0"/>
    <dbReference type="OMA" id="MDDGFQN"/>
    <dbReference type="OrthoDB" id="1382484at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW67908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="327" mass="34571" checksum="AEC2BAA14EF2CB08" modified="2011-04-05" version="1">MKRPWLAPLVPVYWAGLWVKDALRAEAKRLARPVISVGSLSAGGAGKTPVVMALVELLGRHGVTADVLSRGYGRGSGVVELVDAAGDAGRYGDEPMLMARAGIEVWVGAERVEAGRAAEKYGQAQVHVLDDGFQHRGLGRDLDVVLLTAEDAGDWLLPAGNLREPLGALARAGAVVVREEEMAGLAGLCAGKEVWVVRRELVLPAERPGRVVAFCGLARPEGFFGMVRGAGVEVVGTHAFGDHHAYTGADVEWLLAAAERVGAEGFVTTGKDAVKLTAGMVERLGRVVVGELKASFLDEAGVWERIREAVTKQTTAKTNTEVLASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X195</accession>
    <name>E8X195_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580367.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2004"/>
    <dbReference type="EnsemblBacteria" id="ADW69049">
        <property type="protein sequence ID" value="ADW69049"/>
        <property type="gene ID" value="AciX9_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2004"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045680_8_2_0"/>
    <dbReference type="OMA" id="HYPKSAL"/>
    <dbReference type="OrthoDB" id="1022681at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05828">
        <property type="entry name" value="Sortase_D_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041999">
        <property type="entry name" value="Sortase_D_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="21659" checksum="B143A2C104EE772B" modified="2011-04-05" version="1">MRETVSAIRKLVRNCLYGVATSCLVIFLIVYITSIQADAASKTIIACEQERDTNKVNVNPNTGGSTEGSILGRIEIPQLKLSVALMDNYEAADLLKGVGHIPGTAMPGGLGTVGIAGHRDTYFRSLRGIKVGMGIELSDATGTYHYSVDSTEIVKPSQIEVLDVRQRPELTLITCYPFNFIGEAPLRFIIHAHLLSVIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D1</accession>
    <name>E8X1D1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2040</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580402.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2040"/>
    <dbReference type="EnsemblBacteria" id="ADW69085">
        <property type="protein sequence ID" value="ADW69085"/>
        <property type="gene ID" value="AciX9_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2040"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_4_0"/>
    <dbReference type="OMA" id="FWADPYA"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21943" checksum="B24020E9814CA0A0" modified="2011-04-05" version="1">MTNLLFIRHAQTDLAGTFCGQSDPNLSEIGLSQLPNLLERLAPHAIDAVYTSDLRRARETAESITYARHIPLNLTPELREIAFGDWETLTWETIEQRDPTYAARWVAEFPNLPTPNGEPITQFRQRILNALYDLRQKAATTNIAVVTHAGVLRVLLEEFGHFSPHHAWERTRDYTCIVHCTQTSPESTLVIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E6</accession>
    <name>E8X1E6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional protein HldE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">D-beta-D-heptose 7-phosphate kinase</fullName>
                <ecNumber evidence="9">2.7.1.167</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">D-beta-D-heptose 7-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">D-glycero-beta-D-manno-heptose-7-phosphate kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">D-beta-D-heptose 1-phosphate adenylyltransferase</fullName>
                <ecNumber evidence="9">2.7.7.70</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">hldE</name>
        <name evidence="12" type="ordered locus">AciX9_2055</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 9">Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.</text>
    </comment>
    <comment type="function">
        <text evidence="2 9">Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="ChEBI" id="CHEBI:60208"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.167"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.167" evidence="9"/>
    <dbReference type="EC" id="2.7.7.70" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580417.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2055"/>
    <dbReference type="EnsemblBacteria" id="ADW69100">
        <property type="protein sequence ID" value="ADW69100"/>
        <property type="gene ID" value="AciX9_2055"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2055"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021150_2_1_0"/>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033785">
        <property type="term" value="F:heptose 7-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01603">
        <property type="entry name" value="HldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023030">
        <property type="entry name" value="Bifunc_HldE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02198">
        <property type="entry name" value="rfaE_dom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="10">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="11">
        <location>
            <begin position="359"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribokinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cytidylyltransferase" evidence="9">
        <location>
            <begin position="358"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="53064" checksum="4FEC709695D2797C" modified="2011-04-05" version="1">MLPELHSVLELLEHGFGELKILVVGDIMLDRYILGEVERISPEAPVPVLRHAQRYERPGGAANVAMNLAGLGCQTLLAGFWGADAEQGELVKLLEAAKIDTVGVVSSSLPTISKTRIMAKTQQILRLDIESRDKAPMAESERLEARAVELVTKVHAVILSDYAKGVLTDKVCEAIIRAARMAGVPVLVDPKTKDFSKYSGATTVCPNLNELSLATGVPAHQTAELLAAARVQMTEHDFKFLTVTMSEKGITVLGPEGDFHSPARAREVYDVSGAGDTVIAVLAAALAGGLQTRTAVELANLAAGIVVGKVGTVPIAQHELISALTPSSGITSGEKILDWERVQRRVTEWRAAGETVVFTNGCFDLLHVGHITLLEECRRFGSKLVLGLNADASICRLKGPSRPIVGERERARVMAALASVDAVVLFEEDTPLELIQVLKPDVLVKGGDYSIETVVGHEDVIGRGGRVEIVPIVEGFSTTNIVRKLTTPAEEHQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P7</accession>
    <name>E8X1P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease, Rne/Rng family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0898</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579290.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0898"/>
    <dbReference type="EnsemblBacteria" id="ADW67966">
        <property type="protein sequence ID" value="ADW67966"/>
        <property type="gene ID" value="AciX9_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0898"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_7_0"/>
    <dbReference type="OMA" id="HIALPGR"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1344" mass="146855" checksum="88B2A6D5264176BA" modified="2011-04-05" version="1">MSKEIYISSTPHETRLAIVENDELAEIYYERENEYTLAGSIYNGKVTRVLPGMQSSFVDIGLERDAFLYITDFMEEAGDSADFEANANGADKAPRGDRNGGGNDRGRDRGPRQDRGDRSDQARLPERSAEPTDADLFTEAVSGLDPARPVAPRNGNGAGSELERSDRGDRGSRRGGRNRRDRGAFNSDGTPRRDRGESGNRADAGNRTDRPAQSFVAPVETPVEATPAAGNDELGEGAPGADGSRRWRGRRGRRGNRGPGREGQATQGAEAPAGEEFIVAAPGFEDSVEPAFDGGYDMGASAAEAEAPVAEVSERAPREGRNDRGGRGGRDRGGNRGRGDRGGQQAPPRVPRGFAPSLSLYKVDGSADEAPEYQEQVPAPYGFEAEVEAPIEPIILPGESLRKYRTDLPEEKPIEAAAPAAAEDFALKGAWDGGLVLPGETIRPRGPGADSGSSSSGRSEGRGRDDRGSRDSRGGDRGRGGDRGRGGRDDRGGRDRGPREDRPREDRGPRAEYAAPVAAPVPFVAPAVEAEPLTASHGVEVEQAPFESGQGHVVPVEVAQAESVEQIHSTFVPPPPMPEQVEVAAEPEFVEHVQEFEPTEGSASFRVDPVPPSEYRQSAPVETPEFSDAAEEHITPTHEAAHEAHEQVIEHEVMEHEEIAPEVVEHDVTSISATGEMHSEAPTEAAHELPAMEIAEPTAPIAHEGAVVEQKQVAAHFQPGDGHLEEEEMFDEEEEVLPSLHAQSGESFQHSDHSDHSEQETLEGVADLGTMLREMSIDQITRTEPTEGIDEDDLEEDFLEEDQDYDSASGEGEFEEEEGGEEGLSDEGLEGIEDAEYGKGFEGAHVQEGGEAAAPVRTDANVSREPRRDRDDRGRRDGRRGDRGRRDRGSDRGSDRGGDRNSERGSFTSPGAGSDRPERSSSDRGGSRDSRGGRGSRQSMQSTNLPAISELLKPGQEILCQIAKEPIAKKGARITSHIALPGRFLVFMPTVNHTGVSRKIESDGERRRLKEILLSEKGEASGGFIVRTAASGASEEELRSDLRFLLNLWADIKARSESSKSPALIYHDLNLVERVLRDQVTDTFSAIWVDTETEYERVLRFLQRFQPSLIRRVKLYTKETPLFEQFGITEEINKALRSKVWLKSGGSIVINQTEALVAIDINTGKFVGKTARLEDTIVKTNLDAIPEIVRQIRLRDLGGIIIIDFIDMDERKNRNKVMAALEEELKSDRAPSKVLQFNDFGLVAITRKRVKQSLERTLSTTCGVCAGTGMVKSPVTVCNDIYVEMRKMHKHLDRGDVMLRVHPEVVKQLKSGTSRWLQEMEEMCGKTILVKSDPSLHPEQFDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R2</accession>
    <name>E8X1R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0914</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0914"/>
    <dbReference type="EnsemblBacteria" id="ADW67981">
        <property type="protein sequence ID" value="ADW67981"/>
        <property type="gene ID" value="AciX9_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0914"/>
    <dbReference type="eggNOG" id="ENOG502ZST6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958984_0_0_0"/>
    <dbReference type="OMA" id="FYFFFDE"/>
    <dbReference type="OrthoDB" id="1117977at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="31149" checksum="7F9A47441A5BDDD3" modified="2011-04-05" version="1">MLLSLILSITTLCTAQTPQHTAEAPGILEGPQAIGTAPALAKSPEPALMNNDAVLRMVKAGLGDGLVLQTINAQPGDYNVTPDALIALKQAGVSEEVISSMVNAVANKSRRQITNVPVAPVVLSDVNEPGVYYKDRQGRWTLMETELVHSKSGGFIKSTVTYGIISKDMNGVVFGRESKLLLSRPVEFLIYTPDGVTSEEYDLLQFRLNSKDREFRTLTGGVFHSTGGAKRDEVPFKAVKTAPHTYTFSLPEDLPGGEFGVLPPGTGNVTNGGKIYTFAISEDDRKVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1S6</accession>
    <name>E8X1S6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ordered locus">AciX9_0928</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579319.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0928"/>
    <dbReference type="EnsemblBacteria" id="ADW67995">
        <property type="protein sequence ID" value="ADW67995"/>
        <property type="gene ID" value="AciX9_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0928"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_0"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="123" mass="12497" checksum="B1028DCA185106D4" modified="2011-04-05" version="1">MADIQQLEDSIVSLSLLEASALVKKLEERLGVSAAAAAAAPAAGGGAAAAVVEEKTEFNVILKDAGANKISTIKTVREVTGLGLKEAKDLVDGAPKPLKEGVSKDDAAAIAKKFEGIATVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Z5</accession>
    <name>E8X1Z5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tagatose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2112</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:22948"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase LacD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.40" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580472.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2112"/>
    <dbReference type="EnsemblBacteria" id="ADW69156">
        <property type="protein sequence ID" value="ADW69156"/>
        <property type="gene ID" value="AciX9_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2112"/>
    <dbReference type="eggNOG" id="COG3684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058971_0_1_0"/>
    <dbReference type="OMA" id="KDITRPS"/>
    <dbReference type="OrthoDB" id="1560751at2"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019512">
        <property type="term" value="P:lactose catabolic process via tagatose-6-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00734">
        <property type="entry name" value="LacD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005927">
        <property type="entry name" value="Tag_1.6-dipho_adolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="36398" checksum="421394C4E45D87D1" modified="2011-04-05" version="1">MKLTPGKLAGLKAVSDARGVIAAAAMDQRGSLQKSLAKERGGIIDSAALGEFKTLVTEVLTRHASAILLDPEFGLEASKNRNSAGLLLAYEKTGYDSATPGRLPDLLDVWSVRRLKEAGADCVKILLYYSPFEKTAINDLKHAWIERIGDECIAHDIPFFLEFVGYDAEGGDEKSLAYAIKKPLIVSGSMAEFGKERYNVDVLKVEVPVEMSYVEGTKAFKGEKAYTRAEALQHFRDAETMTHKPFIYLSAGVSNPVFIETLALAAESGTKFNGVLCGRATWKDGIVIYAKQGAAAFKEWLETTGVENISNVNEALKAATPWYTKFGANSLAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>E8X200</accession>
    <name>E8X200_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="16" type="ordered locus">AciX9_2117</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580477.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2117"/>
    <dbReference type="EnsemblBacteria" id="ADW69161">
        <property type="protein sequence ID" value="ADW69161"/>
        <property type="gene ID" value="AciX9_2117"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2117"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_0"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="14">
        <location>
            <begin position="67"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="15">
        <location>
            <begin position="248"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="450"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="690"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="617"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="855" mass="95388" checksum="ED37DF864FD40EA3" modified="2011-04-05" version="1">MSDISLPENAGNSPQSDAASAEPNQPQRYTPAEIEPKWQARWDADPSLYAADAHDSGKPKYYCLEMLPYPSGALHIGHVRNYAIGDALARFMWMRGHNVLHPMGWDAFGLPAENAALKNNVPPREWTLSNIASMKKQFQRLGMGFDWSKEVTTCLPDYYRWNQWLFLKMFERGLAYRKKSKVNWCPQCATVLANEQVIQGRCWRHDETVVEQRDLTQWFLRITKYADELLTGLDKLEGWPEKVRTMQRNWIGRSEGTNVDFMVANAPASASNGSKITVFTTRVDTIFGATSIQLAPEHAVAKAFAAEDPRLAEEIEALLLQQQKARETDELGAIEKHGVPTGRFAVNPFNGERVPIWVANYILADYGTGAIMSVPAHDERDFEFATKYNLPIKRVIAPNLDTDDLPLPYLAEEEAVLIDSGEWSGEACLEAQDKMAAFVETGSFGSKTVTYRLKDWGVSRQRYWGTPIPMVYCEACGADEPIPVPESQLPILLPEQIAITQEGGSPLGRVPEFVNTTCPKCGGPARRETDTMDTFVDSSWYFYRYTDPHNDTAPFDSAKVNYWFPIDQYIGGVEHAILHLIYSRFWTKVMRDLGLIVNDEPAERLFTQGMVIKDGAKMSKSKGNVVSPDLMIDRYGADATRMYALFAAPPDRDLDWQEEGVAGISRFLGKIFRLTTKFAQLEGGEAGPADAALLRKLHQTIAKVTHDFSGRWHFNTSISSIMILVNEITANEAAIDAGQVTAATVKSTLRSLIQMIAPFAPFLAAELWETLGEQGIVFRHPWPESDAALAREDEISIPVQVNGKLANVIKLPSESTDEEVKAAALLDEKVAARIAGKTIVKVVYVPGKLVNLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X283</accession>
    <name>E8X283_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579339.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0948"/>
    <dbReference type="EnsemblBacteria" id="ADW68015">
        <property type="protein sequence ID" value="ADW68015"/>
        <property type="gene ID" value="AciX9_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0948"/>
    <dbReference type="eggNOG" id="ENOG5031NYW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286444_0_0_0"/>
    <dbReference type="OMA" id="RLPYAYS"/>
    <dbReference type="OrthoDB" id="1706132at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="231" mass="24972" checksum="9B10132CD8AD73BB" modified="2011-04-05" version="1">MTSPARVMAVNLKRQTKDWLSPLNLHWAGLGLLGLVNLYLIIHMAFAWRTASSQNAEALAQQQVELKTAEIAARPLQGLDAKLKDASQNADRFALERLPISYSEVASELGKLAKTDNVRLTRVQYAQSAVDGDAAGQLTQVQMDASLSGDYRSLVTFINGLERDRVFFLISAVALTGQQTGQVNLRIRINTYLRGVGSAEEMARVQLDTEAAKTPAPAVVPISAPVAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X299</accession>
    <name>E8X299_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, group 2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0964</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579355.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0964"/>
    <dbReference type="EnsemblBacteria" id="ADW68031">
        <property type="protein sequence ID" value="ADW68031"/>
        <property type="gene ID" value="AciX9_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0964"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_2_0_0"/>
    <dbReference type="OMA" id="TCLYHGV"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="PTHR12726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="395" mass="43696" checksum="2E272D8A1FD54512" modified="2011-04-05" version="1">MGWLLRVLFYVALAGSVTSSIYCLMVVAAAVRFGLRKRRDERASEDFLPPLSVLKPLHGTEPGMERNLETFFEQDYPSFELLFCARHATDQGLILAERVGQRYPQVNAKYVTCGEPMPKFHNAKVFSLEKLDSVAAHELYITSDADVRVAPNYLRRMVQNLKDPKLGIASCVYLGTAYGGEGSSFAAKLDAVGKSVEMTSGVLVADMLEGTKFALGATMAVPKKSFQAVGGFAELGQFYADDFELGNRLAKQGQGVKMATHIIKLMVQDTPFWLSFRNQLRWMQSTRRSRPWGHLGSGLTFAMPFGLLGLVWGLASGHALAGVLWLLGLVVNRWLQAGTILGVMGDPDWLRNVAIYPLRDMLGSMLWLGSYGGEKFYYRGKIYTLKPGGRVEAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A7</accession>
    <name>E8X2A7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0972</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579363.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0972"/>
    <dbReference type="EnsemblBacteria" id="ADW68039">
        <property type="protein sequence ID" value="ADW68039"/>
        <property type="gene ID" value="AciX9_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0972"/>
    <dbReference type="eggNOG" id="ENOG50331S2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079341_0_0_0"/>
    <dbReference type="OMA" id="ACWERRE"/>
    <dbReference type="OrthoDB" id="2087928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="32615" checksum="A70186E16A22D528" modified="2011-04-05" version="1">MTTIVDAPSRTIARTAFEAPLIYWHLLSLDAPTVAALWTWFVARSAHISLPLSSVAAMFLAVWILYAADRLLDAQQLESAVPSDLEARHLFHHKHRKLFRIVILVCSLALAPLLLTIPAEAIRLYLIAGSLLFAWFVLIHAAPVLHGGKPGRLPKEIAVGVFFAAATFIPTVSRAPALRLSLLLPAILFAALCSLNCLFIYAWEHPTPSVTATAHPTTRVALHSLTLLAPILTFVAFLLAVLQHNEFSPLLMAIALSASLLRLLHQTRPASRIALRAAADFVLLTPLLFIPFQHWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C1</accession>
    <name>E8X2C1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Luciferase family oxidoreductase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0986</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579377.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0986"/>
    <dbReference type="EnsemblBacteria" id="ADW68053">
        <property type="protein sequence ID" value="ADW68053"/>
        <property type="gene ID" value="AciX9_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0986"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_0_0"/>
    <dbReference type="OMA" id="APGSDQM"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="37511" checksum="4B32104F03945684" modified="2011-04-05" version="1">MSLLRLSVLDQSPVPSGSTPAQALRNSISLAQHVESLGFNRFWMSEHHSMETLACTAPEIMLARIGAETTKIRLGSGGIMLPHYTALKVAETFRTLHALYPNRIDLGIGRAPGGGPLEAAALRRNRNVPQVDDFLDQLSELIAFLHQEFPPQHPFSKIMVTPEMPGGPDVWLLGSSMWSSETAAHFGLPYAFAHFFSPDPTRRAIENYQADFQPNLSLGVQARTSPEAMAAVGVICAETQAEADRLALSVRLLQLRIRMNDRRPVASPEEAAAELPQHGPAAPETGEFPRYVVGTPDVVKEQLTAMADALKIKELVVNTIVHDHAARLRSYTLLAEAFAATKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L7</accession>
    <name>E8X2L7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2197</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580557.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2197"/>
    <dbReference type="EnsemblBacteria" id="ADW69241">
        <property type="protein sequence ID" value="ADW69241"/>
        <property type="gene ID" value="AciX9_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2197"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051806_4_1_0"/>
    <dbReference type="OMA" id="SWIATRT"/>
    <dbReference type="OrthoDB" id="1365029at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="37323" checksum="1DCACAE87233E202" modified="2011-04-05" version="1">MRDEIEKIPRGFEIALFGTAMLWALASSAIASRSAHGIVVRFKLDTIESLLSAVFLVFLVVVGFSLLDWIATRGRSDADALPLPRRAGWGMEWGVGAAVGWGLCLVAVLPVLLIGNLHGRLMLSGATLWSAALSALTLLAMTLAAELIARGYGFQRLIVAVGPSWASVITSFGFAAALVWGNPPRHLLVALIDGTVFGLVLAVAYLRTHALWVGWGIHFAYRVMMAVVVGLPIAGRNDFGSIMDTYTTGPGLLTGSGFGLDGALLTALVMAGGMVVVYRVTKEYAWKYTLPEIVAAGYEVTVAPPAAHTAMEKAAAPAPLVQILATTPQTRSVVSPVEPPRPEAEHDFRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y5</accession>
    <name>E8X2Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1056</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579442.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1056"/>
    <dbReference type="EnsemblBacteria" id="ADW68119">
        <property type="protein sequence ID" value="ADW68119"/>
        <property type="gene ID" value="AciX9_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1056"/>
    <dbReference type="eggNOG" id="ENOG502Z9BM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053114_1_0_0"/>
    <dbReference type="OMA" id="SIHHDGW"/>
    <dbReference type="OrthoDB" id="1079090at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="312" mass="35045" checksum="44F00D5123084AB6" modified="2011-04-05" version="1">MMKLHPVAKVAVALSFVPFVFVQRSAAWGADGHRMINRLAAQYLPADVPAFMRNGEAQDTLEYLGPEPDRWKNRAESELSATQSPDHFIDMEWADLVGTLPKRRYDYIREVDKIAPAHPELKLTAEKIGFQPWEVEENYQRLKVAFREYRKLVAANADTGPDKKAILFYAGWLGHYVADGSQPLHDSIQYNGWTGPNPNGYTTEHKIHAKFESTYVSANVPRVEIAALVAASTPKLMTDEWSDYLTYLRTSEGQVEKLYQLDKAGAFDGAGTPAGKAFTEERIAAGVIELRDMIYTAWVRSGDPVEEYKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C6</accession>
    <name>E8X3C6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3421</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3421"/>
    <dbReference type="EnsemblBacteria" id="ADW70427">
        <property type="protein sequence ID" value="ADW70427"/>
        <property type="gene ID" value="AciX9_3421"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3421"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_76_0"/>
    <dbReference type="OMA" id="ETNRGVM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="232"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="473"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="613" mass="67393" checksum="644D1239EA1A08C6" modified="2011-04-05" version="1">MASTANPRPLLSVSVARDMDFLLARQRAKQIAALLRFDRQDQTRIATAVSEIVRNAFEYAGGGRVEYFLDINTSDGPTFRIVVADNGKGIPQLDQIWNGAYRSQTGMGLGLIGSRRLLDDLQVETSPKGTTVSLLKRLPRNVSAPDIAELSTQLAIHTVGQPSALQSAALIDQNQELIRLLDEIRARESELHILNEELSETNRGVLVLYAELEDRARAVQHASELKTRFLSGVTHELRTPLNSIVSLSRLMLSHSDGSLSTEQEKQVNFILRSAQNMTELVNDLLDLARVEAGKAISNLTYFTVADLYAGLRGMFRPLATNPSVKLLFDIPSEPLRLHTDEGKLAQILRNFISNALKFTEHGTVTVSARPREGSPDWVTFTVVDTGIGIAPEHHEIVMQEWGQVEHVQQAAHGKQKGSGLGLPLSRSFAELLGGRIHFTSEPGQGSTFEVSLPALVSEPAPEPSAVNDLDQGHIIMADDDEVARYLLRRRLSAHTTAEITEACSGQEALDAIRRHRPHILFLDLVMPGLSGFEVVRQLRQDPTTADLPIVLHTSKTLSPEETRSLEAYDLTLIPKGSKTQGGTDDPDAPDEQSIQLQRALLQVGLHNMHEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F2</accession>
    <name>E8X3F2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3448</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581764.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3448"/>
    <dbReference type="EnsemblBacteria" id="ADW70453">
        <property type="protein sequence ID" value="ADW70453"/>
        <property type="gene ID" value="AciX9_3448"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3448"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_3_0_0"/>
    <dbReference type="OMA" id="GIVWNSQ"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="46534" checksum="CBBF0309634C9C6A" modified="2011-04-05" version="1">MKRIAIIGGGIAGLTCAWQLHQLGQPFTLYEATPRLGGTVRTLHRDGFTIEQGPDGWVTEKPWAAELARDLGLGDELTPSNDAGRVTWIVRDNKLMAMPDGMRMMVPTDLLALEGSPLFSDEARAAYAAEPARAEELRAAAPDQDESIAAFVLRHYGHEVLNAVAAPLLAGVFGGDVWKLSVRAVMPRFVEMERQHGSLITALQSLVRRDSPSIFTTLASGLGTLIDRMAAALPAGSVRMSAPINSIPDSDHIILATPAHVIRTLLRGLAPERAVELLPAEASSAVLVALAFDEEFALPAGFGFLVPHSEPSQLLAATFVDQKFPGRVPPGKRLLRAFFGGANGLALTSLDDGALAALAHAELVRILGPLPVPAFSTVQRWPLSLPQYEVGHLDRMTELAGLLPSNVHLLGNAYRGVGLPDLIRDARALARQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X411</accession>
    <name>E8X411_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin dinucleotide-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3514</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581830.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3514"/>
    <dbReference type="EnsemblBacteria" id="ADW70519">
        <property type="protein sequence ID" value="ADW70519"/>
        <property type="gene ID" value="AciX9_3514"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3514"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_0"/>
    <dbReference type="OMA" id="CPLDCPD"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="738" mass="79442" checksum="BD71A26602FAE172" modified="2011-04-05" version="1">MELVGESGRRVVHAVCSHDCPDSCGVLVTVATDAAGQERAVKVEGDPNHPVTRGFLCGKVAKYLDRVYAPDRLLYPMKRKAGVAKGPLVQGREMEAFERITWDEALEVIATRLQGISDEFGPESILPYSYAGTIGQLGYGSMDRRFFYRLGASQLDRTICATAGGAALTSVYGVKLGTVPQDFAHAGLVIAWGANIHGNNIHLWPFIEEARRKGARLVVIDPYRTRTAALADEHLAINPGTDGLLALGMMHVIFSEGLEDAAYLAECTVGAAELRAHALKAEHAPEVVSLATGISVEKIVGLAREYAGCLKRTGKPAVIRVNYGVQRSENGGTAARAVAMLPLVTGAWKHKGGGLLLSTSGSFPFDNNTLQRPDLMYASPLGRAARVVNMSQLGQALTELGSEAKDGPPVKALFVYNSNAAAVAPNQNVVLAGMRRDDLFTVVHEQFFTDTADYADVLLPAPTFLEVKDVQGAYGHLFAQVSNRAIAPLGEARSNVRVFGELGQRMGFEEDCFKDGDDELIDQTLASGNAWFEGITRERLEREGHVALRLPGNEAGETLPFSTAEWFRTPSGKGELVPVPVYVAPEESRARATGEYPLEFLGRKADNYMNSTFANQAVHQRMEAKTDGVLEMHADDAQARSVQTGDEVEIFNARGRIVLKVGINGKINRGVVAARLDWAKLGQDLSGRGANVNALTSERVTDLGGGATFYSTLVEVRKVERPAAALAHPSSEETNDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X439</accession>
    <name>E8X439_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0008</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0008"/>
    <dbReference type="EnsemblBacteria" id="ADW67099">
        <property type="protein sequence ID" value="ADW67099"/>
        <property type="gene ID" value="AciX9_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0008"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051844_0_0_0"/>
    <dbReference type="OMA" id="THEKSMV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234150" evidence="1">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="36454" checksum="EB31E9CBC55C358B" modified="2011-04-05" version="1">MRSGLRVLGWMLIGVLAASAAGQAGTHSRHAGRVDTVTSGTRVLYTFPQSNNSATPLYALVNGSLKTIDMTMYELVDTVFSADLVAACKRGVKVRVILDQNLEKSSNTAAYNQLNKTTNCSAAWANPAFQATHQKSMIVDGTKLAIITLNLTTRYYTTSRDFALVETDAADIAAVEATFNADFKSTTSFAYQPGKGTDLIWSPTTATADLLGIINGATKTLLVENEEMGAANVVSALEAACKRGVAVHVAMTNLTAYKTEFAALKAAGCGVHLYASTATGLYIHAKVLVADYGLSTQMVYVGSINFSIPSMTDNRELGLYVSDATIVKALQTQVTTDYAGAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q8</accession>
    <name>E8X4Q8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3542</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581858.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70547">
        <property type="protein sequence ID" value="ADW70547"/>
        <property type="gene ID" value="AciX9_3542"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3542"/>
    <dbReference type="eggNOG" id="ENOG5032KAC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101661_0_0_0"/>
    <dbReference type="OMA" id="RSASWWL"/>
    <dbReference type="OrthoDB" id="1691473at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27649" checksum="3EDAEE7DF720656B" modified="2011-04-05" version="1">MSEAAYPSSASVSEPQGLNQIERVVDAFIAPSKTFKDILRSASWWLPFILMVLSATSLAWVVDKQVGYDHVAENVIHQSPKAEDRMSSLSPEQRASSMHMVAMQTRIGAYAAPVFLLIFFAIYALILWASFNFGLGAQTTFWQVFAVSFYAALPYIFINLIAIFTIYFGGSAEAYDMKNPAGTNLGYYLPDVSPWLKALLGQLDVIKLWTLALTVLGMAIVAKKSITQSAVIVVGWWLVLVVIAVGFAAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V4</accession>
    <name>E8X4V4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3590</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581904.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3590"/>
    <dbReference type="EnsemblBacteria" id="ADW70593">
        <property type="protein sequence ID" value="ADW70593"/>
        <property type="gene ID" value="AciX9_3590"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3590"/>
    <dbReference type="eggNOG" id="COG1942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_0_0_0"/>
    <dbReference type="OMA" id="PEDDQFM"/>
    <dbReference type="OrthoDB" id="2013680at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037479">
        <property type="entry name" value="Tauto_MSAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38460">
        <property type="entry name" value="PTHR38460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14552">
        <property type="entry name" value="Tautomerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="14270" checksum="012310438D9DD391" modified="2011-04-05" version="1">MPFARIDLAKGKTPEYRATVADVVYDGIVNVLKAPEGDRFMIIGEHAPDNFVFDPNFLNIKRTPDLIILQVTSTVGNTKEQKLAFFRHMADELNRRLNVRREDVFISLVFVDRDDWSFGNGEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W3</accession>
    <name>E8X4W3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581913.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3599"/>
    <dbReference type="EnsemblBacteria" id="ADW70602">
        <property type="protein sequence ID" value="ADW70602"/>
        <property type="gene ID" value="AciX9_3599"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3599"/>
    <dbReference type="eggNOG" id="ENOG502ZEJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556569_0_0_0"/>
    <dbReference type="OMA" id="DARYFAN"/>
    <dbReference type="OrthoDB" id="400594at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="515" mass="55428" checksum="328B36176186AB06" modified="2011-04-05" version="1">MRRSLVLGVVGVCGLAVGCGLTKKAEVAEKAGPGQMPANTVMLSEVMRELSEKPGFTDALLDQLQKGAGHKGAGAALLTPRLIDRMREMILGKDWQGLDRFPGWTMREINPTVRMVGHVVGKDPKVEASATAGGAPSGTPGVVGNKDALAFIDLGADLLSKGGVEDLDMPSRLPGFDAKALVSELGADVVRGDGPNVDRAGRHAESARLAEVLNRLSLNGMDGAAKFQASVGGKTVATPQDLIVALGETGHEVMVADSRYFANFGHLHYKGQDVMMPFWVNSQIVVPETKRPLLVPVSHAEYEWFVRGPKVNAEVSFYFGIDGKAEFRTMDQLDQAWVMNRHAHEYKGADAVEVTRLSGAMVQTYMHQHADRPKLPFGGYYALGVCQDVVAAIELRMTGKTTLFPNTADGALFDDARDAEINKLIKAIPKDRAGRPSEVERIFGSLPVGSSDGELASVSIPGLGADLVAVHDAWTDGSLRRVTPKWVMWGRRGAALLGLVLGFGVAFWVRRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z9</accession>
    <name>E8X4Z9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0108</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578519.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67191">
        <property type="protein sequence ID" value="ADW67191"/>
        <property type="gene ID" value="AciX9_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0108"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113764_2_1_0"/>
    <dbReference type="OrthoDB" id="1839196at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10356" checksum="5BD7A73626048DC6" modified="2011-04-05" version="1">MSGARVARKYGINANQVFQWRRLQQDGLLGPAAEDSAKLLPVSMIEERRLAKPETLAVPACGGKIHIELPGRVSIRLEGNVDAATARLILKSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X510</accession>
    <name>E8X510_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0125</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578530.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0125"/>
    <dbReference type="EnsemblBacteria" id="ADW67202">
        <property type="protein sequence ID" value="ADW67202"/>
        <property type="gene ID" value="AciX9_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0125"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_4_0"/>
    <dbReference type="OMA" id="NLAWCHP"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="725" mass="79112" checksum="C610613A13FC6C47" modified="2011-04-05" version="1">MSIVHRFKRLVGIDTAQEKYSYAQDPLYGKVSTARVADTWVKTTCGYCSVGCGMLVGVKDGKAVAARGNPDHPVNRGKLCPKGLSEHHILDGPGRAKLPLLRKNGKLEPVSWDEALSTMVERIANIQGRHGLGSLGVVGTGQLLTEEYYTLGKLVQLGFRTPNNDGNTTLCMASAVSGYKLSFGSDGPPGSYADMSTADVVLLIGSNIADNHPILCTRVGEGPDKRPGRTLIVVDPRVTKTAMMADIHLAIKPRGDIALINGIAHILIRDGLTDSNYIAAHTINYDAFAAYVAAFTPQHVSEITGLSVEKITKVAHLYGRARAGFIGWTMGVNHSTQGAVTVAAINNLALITGHIGRAGAAPFSITGQCNAMGTRESGFTSALPGYRKFDNPEHREELAQIWGIDAEEIPKARGMAYPDIIEGAVTGKIKALWFIATNPVVSFPNYELLKQALESVEFVVVQDGFHPTPTSDFAHLVLPAAIWGEKEGTYTNSERRISKVNCIVTPPGEARSDFDIFLALAERLGVRDRLYPGWQTTADAYAEWQRVSAGRLCDYSPYSWKEIEDAGGIQWGGERLYADGAFPTADGRAILHNVPCDPFLEQPNEEYDFILNTGRTVEHWHTRTKTAQVDMLNKMVPNAWLEMNPVDAKRLQLRAHDKVTVTSRRSNVSGLELRITSIIAPGQVFMPFHFAETNSNRVTLGAFDPISREPNFKQCAVRVQKSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X523</accession>
    <name>E8X523_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0139</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578543.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0139"/>
    <dbReference type="EnsemblBacteria" id="ADW67215">
        <property type="protein sequence ID" value="ADW67215"/>
        <property type="gene ID" value="AciX9_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0139"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_0"/>
    <dbReference type="OMA" id="YKCSVQN"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="26848" checksum="C6B0A48E3E413171" modified="2011-04-05" version="1">MNRFDGKVVIVTGAGSGIGAATAKRFLAEGALVVLNGRRKDKLSETAEGFDDGRVLLHSGDIADEGYVKQLIEATVAKFGKIDVLVNNAGVSAFGPILDSTTEQWRKVMSIDVDGVYFAIRAALPHLLKTRGNIVNVSSVSGLGGDWGGSIYNTAKGAVSNLTRALALELGSQGVRVNAVNPSLTSTEMTAEFEKNDKLIAKFTDRLPIGRGARPEEVASVIAFLASEDASFVNGVNLPVDGGVTASNGQPNMTGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F6</accession>
    <name>E8X5F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580819.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2470"/>
    <dbReference type="EnsemblBacteria" id="ADW69503">
        <property type="protein sequence ID" value="ADW69503"/>
        <property type="gene ID" value="AciX9_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2470"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_2_0"/>
    <dbReference type="OMA" id="VNAQPWR"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="215" mass="23784" checksum="D3F112C1A1F15F2D" modified="2011-04-05" version="1">MPKSVKSLSQAIQGRRATPSFDEAPMPEEDLQQILDAGLRAPSGYNMQPWRFIVVQSPEGKKKLRAASYNQAKVEEASAVIVACGDADGWRKDLDLMLQLGREGGMPESYAAQARTSVSGYLSSFTPEQMKLWLTKHVMLAYTSMMLMAEVLGYDTAPMEGFEQEKVHEALRLPLSYTVVALLAIGTLKGVDKFDGGRFEMAHTVFGEEYGRPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P4</accession>
    <name>E8X5P4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70671">
        <property type="protein sequence ID" value="ADW70671"/>
        <property type="gene ID" value="AciX9_3670"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3670"/>
    <dbReference type="eggNOG" id="ENOG5030AN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1045459_0_0_0"/>
    <dbReference type="OMA" id="GPIWRIE"/>
    <dbReference type="OrthoDB" id="1636981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230257" evidence="1">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="259" mass="28206" checksum="8A78B651613CC471" modified="2011-04-05" version="1">MHVRPLHLASLALLASNLFAEPIPVRHIQGTAHGFLSIRSLDGKLLAAGDLIQVAHADRVTSRLTFHFRDGSLDDETTTFTQSGSFHLISDHHIQRGPSFPKPLDLTIEANGQLTFRILGGDGKPQTTQEHMDLPPDVANGMQLTLLMNLSADSPEIKVPFVVTVGKPRLIHFAVKPEGEETFTIGGVHRKATDFTVKPELGGLVGLVAPLVGKQPPDCHVWIMEGLAPAFIREEGQLYYGGPIWRIEQISAAFPAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z0</accession>
    <name>E8X5Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4094</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70874">
        <property type="protein sequence ID" value="ADW70874"/>
        <property type="gene ID" value="AciX9_4094"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4094"/>
    <dbReference type="HOGENOM" id="CLU_010140_1_0_0"/>
    <dbReference type="OMA" id="RWISLQK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="663" mass="74039" checksum="82211896CEE9B514" modified="2011-04-05" version="1">MDLLQTGLAHHRAGRLSDASHCYTALLRLNPAHADALNLSGVLARQRGDLSVSERFIKKAIHQSPSVATYHHHLAKTHTHQGNTLEAIKGYERAISLNPADADSIELLAKLLLASGTKDEALKLYRQLLSLCPDRPDVYFNLGHLLEFDDDKDASLNIYREAARRFPDNPDAHFNLARKLKAEGQTQQAINSFENVLLLKPDDAETFNYLGTLFHLLGETDKAKESYLLAIKHKPDYPLALCNLGALLMDFGQWQVAEMMLRKAIELDPDLLAAYCNLGSVLAQQGNTVAAIEALRQVLQRDPAHAEALCTLGNTMNNLGDEAGAMKCFHLALKANPGHALTRFNMSTLTLAAGNFAEGWPDYELRWQVRESSRNERHLTQPRWTGEDLRGSSIFVYAEQGFGDTIQFSRYVLLLVELGAQVILEVQPQLFQLLENIHPSVLVITKDSPAASETNFHCPLLSLPSIFETDIESIPACIPNLHTEVGHMAWPEHLASKRLRVGVVWAGNPDHMRDRMRSIPFNQFSHILSASEIAFYSLQKGPAATQFATAQHVIDLDAILLDFTDTATAILNMDLVITVDTSVAHLAGALGKPVWILLHHTPDWRWLRGRVDTPWYPSARLFRQTEPGKWDDVLSEVERELDCHSRAWQSNTHTGIPLVEQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z3</accession>
    <name>E8X5Z3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4097</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70877">
        <property type="protein sequence ID" value="ADW70877"/>
        <property type="gene ID" value="AciX9_4097"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4097"/>
    <dbReference type="HOGENOM" id="CLU_001681_2_2_0"/>
    <dbReference type="OMA" id="QDPAPIG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="751" mass="79880" checksum="ECDB89BB5EDB1865" modified="2011-04-05" version="1">MPLASPTLPPQMSINPNGKQPRIDGPVKVTGSAMYASDHNLPGMLYAVPVCATIANGKITALDLTSAKAMPGVKAIYHHGNIGSLFRSGPPQGFSGVIDEKRPPFEDEVVRYYGQYVAAVVALTYEQAIAAANAVKVTYSSSAPDVSTYLTSTEAPKVDSHRGDPDAAFASAPVKVDQTYVTPTETHNPIELHASVADWDGQAFTLYETSQAVVNHQNVMAQMLGVPQENVRVISRFLGSGFGGKLWPWPHALIAASASRDLKRPVKLVVTRDMMFQNVGHRPQTQQRVRLAATPQGKLLAVMHDSLNHTSILDDYSEGCSEATAYSYSVPNLRATSALARRHVGTPTSMRGPGAVPGLFALESAVDELAVALKMDPIALRLLNEPEKDEGLNMPFSSRHFIECLKTGADKFGWANRTPGVGSMKKDGLTLGWGVAGCSWIAERMGASASFELRNDGTARIATATQDIGTGTYTVLANIVRENTGIPHDRTEVVLGDTNLPAGAISGGSWATASCIPAVVDAIQKAQQTLFGIATAEPNASFPGKKAADLAFTDGKVHLKDQPAASGIPFGDILTKANIRAAAGDGKSEGTFGDPKRKFSTHSFGAQFAEVTWQPEIARLRVSRVVTVIDAGHILNPKPARNQIEGAVVMGIGMALFEETNYDPRFGAPINNNLADYIMATNADVPSIDVTFLDYPDLVLNSLGARGVGEIGLAGIAAAITSAVYHATGVRVRELPVRIEDLLPAATWKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B8</accession>
    <name>E8X6B8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4225</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71002">
        <property type="protein sequence ID" value="ADW71002"/>
        <property type="gene ID" value="AciX9_4225"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4225"/>
    <dbReference type="HOGENOM" id="CLU_046706_0_0_0"/>
    <dbReference type="OMA" id="DCVYTVG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="457" mass="46399" checksum="198D26A530B15E2A" modified="2011-04-05" version="1">MRNRIFLVSNESGQVLVAAAVSLLVILGFLGISIDVGHRQLSKLRLQSATDTAATAAALEIRVCGSLVSCPAMQSAVQSSFIENGYPATPLLLNCATSSDDLTLVLNSPPCAMGSADPNYGKRGYVEVQVAQHVPTYFMKMLGISQFNISARSEAARNPGGACIYALDPTAAGAMSIAVGLGISSQCGIVVESSSPYAFSCLLGLGFTAPYIKVHGGAAGLLCLGSGLQTGALNPTPADPLAYLPAPAVGACGSKVGNSYYGSASAVTILLAGNYVFNPGVYCGGISITAGIGTNVTFNPGMYILKTGPGLLGIPSGGLNLTVSLLSNIQGQGVTFYNYGPVGGISITAPATLGLSNFSLTAPTSGEYGGVLFFQDPGNTSTGVFLASLVSGSKLEGAIYLPNAMLTYGVGAISSAYTIVVAKTLQFNVNVLSTFGNDYSSLDIGSPLNGDSAVLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G1</accession>
    <name>E8X6G1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big_3_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4273</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71045">
        <property type="protein sequence ID" value="ADW71045"/>
        <property type="gene ID" value="AciX9_4273"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4273"/>
    <dbReference type="HOGENOM" id="CLU_238863_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1769" mass="181964" checksum="6072B6236A7DC835" modified="2011-04-05" version="1">MSALRPYVALILALILGLALPSLSAQEPAKIALSSSVARYKPAILSLISQQERDTVSFIENKGQTAPDVLWTAQASGYRAAFLKDSFVLQTLDWDKAASGKPVVEAAAGSGAGSTVQGGAQKVQIREERIQLSGANSNAIIEPLDERTGKVNLFKGKDPSRWISNAPTYARLHYRNIYPGIDLIFYSHGGRLEYDFVVAAGANPDLIRMKIASADAVSTTAQGELRIGTTVHKPVLYQNFEHGKSAVEGSFTLVAPNTFGFHFAQYDKSRTFVIDPTISLLYSTYAGGLHNDQAFSITLDAQGNTFIAGWSASEDFPVTGNALQTVRKNIGVYLYDIVVMKFDSAGSLMYSTFLGGAQNDQGTTIVANADGSVYVGGYTQSTDFPVTSNAYQITAGGGLDGFLARISADGSQLLYSTYLGGTGDEAVTSLLPNADGSLWMSGVASQAGLNASATAYQKKPNGVDNSFVGKVQFDANGKLQIPYLTFIGGSQSGQTNGPGEGWPSSLAVDGTGNVYYAGTTQSSDYPVTATAYEQPVTLSHGCANSPNPNTIGVVTKFSPDLSQVLYSTYFGGKTEDQNGFPYCNQGLTSIHLDTAGDIWLYGYTAESDLPLTSNALSKMLNGNGMANGQDAFLGELSADGTKLLYGTYIGGSGLDSASMMTVDASGNIWLSGISASTDFPTTANALQPLNNTGGSDFTLVQLNPAATSILYSTYFGGTTDNGFNSVPMAVDANGNIHLTGSTSSASFPVTPNALQQVFANGDSGPDGNDIFYAELGTGQIVTATPSTGGNVGDATITVNGVGFQIGATCELTLNGATISSASASVSPTGTSISCTFPLAGVVPGTYNIIVLNPNNGTTFMQTAGFVVASGGGPQLWATIVGRPKIRTGVSSVVTVSYGNSGNTDAYMAPMEIDLPANVSATYGVGVSPKLGSGVQATTSATTASGMRIPLMVPHLAAGESRSYQIAITDAVDSDNYTISAQLGSPWYGSLSAANSELSSRSNTLTTSTSCAAALSGSPTVVDCLDRYLTQYQTSGATAAQAKSLAATLQTELAQSLIGNTPAVSAGTLPSPSSAYVGSTLVVTGLPSTDDTELVHDFATSTQYLFPIDTSHCVVWADNVNDALGGVLYKCTYSIPSPIDGAELFTGNSYSRLDLITNPGNLIPEFDTCWTKSFSVLTAGTELDVQAGRPCSMDSDADDPDDPAGGQDPPPPGPPDPPTTDTISGTTGGSIDPNAKVGNNGDGSGGHFIRATAPLPYAIFFENQATATLPAAMVVVTDQLDPAKVDLTTLSLGAISFGANVIKPKGTANAFTAVYSINSSLSVRIEGSLNQNTGLLKWTLQSIDPSTGLPPTDPTIGFLPADTDGMKGQASVVFNVALKPGMPTGTQISNAASIIFDTNTPITTPTWVNTIDIDAPVSRVTALPATETTITFPVTWSGTDQGSGIVTYNVYVSDNGGTFTLWQSAVRGVTANYTGTVNHTYGFYSVATDGVGNIEATKNAAETATQIVPGLIATTAALSASSTSTSVGTNVTFTATVTPSAGSGVPTGSVTFMDGTTVLGQASLMASGQAYYSSSSLAAGAHVITASYGGTSAFAGSTSPALTVTIQALPADFSIGLSPTSGSVTAGKSVTTAVSITPVNGFNQSVGFSCSGLPSGAGCSFSPATVTPAGGTAQTTLTIQTAQRQALLHELSDSPHRINMAVFGGSLLCLGFFTSKRRRWASLASLCLLATLMLGCGGGSPTAVPVTTTITITATAGSVVHSTSYTFTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P1</accession>
    <name>E8X6P1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582209.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71191">
        <property type="protein sequence ID" value="ADW71191"/>
        <property type="gene ID" value="AciX9_3915"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3915"/>
    <dbReference type="HOGENOM" id="CLU_010140_1_1_0"/>
    <dbReference type="OMA" id="EWRLQTV"/>
    <dbReference type="OrthoDB" id="370520at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="521" mass="57126" checksum="82667865971F0496" modified="2011-04-05" version="1">MSAPGELFEEGLNHHRAGRLDEAEKLYRLALETDANHADSLHLLGMISLEAGRLGESAEMIRRAIVLNPGAASYYANLGNVLQRQGLVREAAESYLQALRIRSDLAEVHVNLGNVFLEAEQLEQAVTWYRSGLTLNPAMAGAERCMGDALRRLGRLEEALEAYERSLRLEPGSADAWHWAGKVLRELGDLEGALRCFRAAQAIEPKHPRAGFGEAMVLLLMRQFGVGWAKYEGRWESLDHGTPMREYAWPVWCGERLESGKVLLWPEQGVGDEIMFAGMLRDAVETGNQVVLACDARLQGLMERSFPEVEVVADGVGVPEGIGAQLPIGSLPGLFRASAGAFEGVRGGYLVADPERRRVLRERYGDERRVVGVAWRSINVHTGVGRSIELEVLAGLFEQARVRWVCLQYGEVEELVAEAVAAGVELVMDDGVDQIVDLDGFAAQVAAMDLVVTIDNTTAHLAGALGVPVWLLLPFGPDWRWGAEGSGSVWYPGMRVFRQTRRGDWGSVVAEVAEALRVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R8</accession>
    <name>E8X6R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3942</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582236.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71218">
        <property type="protein sequence ID" value="ADW71218"/>
        <property type="gene ID" value="AciX9_3942"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3942"/>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_0"/>
    <dbReference type="OMA" id="KHRWGGW"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233750" evidence="4">
        <location>
            <begin position="18"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="5">
        <location>
            <begin position="425"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="621" mass="67281" checksum="F9D2679E961E30F1" modified="2011-04-05" version="1">MRRFRLLSLGVALTLFATPHGGFSQERVALTLQDLLSVDAQVDAAISLDGKTLAFGRAGQIVLMPASGGWPETLTSTQGGKNGLAWSPDGRSIAYASNGNIWLVSVSGGAPKRLTNAPAGGGDPRQSADRAPSWSPDGRWILFESGRRGVNSIMVVSPDGAVTSFLTPPRLEATSAKFSPKGDQIVYTTRARDYFSGRLETLRFDTQSGQPAGKPTILYTAPVDRGGGWSIRGADWSPDGKTLVTVLQNSGWEHIYTLPASGGAPRQITDGQFEDTDPIYSPDGKHIAFISSRGLLEARNVFIMLATGGEPTQLAKFEVPGMVSQVQWSPDSRKLYFNHLSPVETSNLLVQDLGSTSAPSYLTHTTPVNFKAAARVPERVTWKGLDGKEIVGMLYTPVAPKPGIPPKYPALLWIHGGPEAQDGYKFDAWAQYLTQQGYVVLEPNYRGSTGYGEVFRNLNVEDSNGGEIDDVAQGAKYLIDRGLVDPKRIAIGGGSHGGTMTGYAVVRYPQLFAAAMELFGVLDRELFVYRTNPSSSVRWMMKMGGTPEEKPEVYKKANVLLSVDKVQAPILILHGENDPQVPPIESAEFAKALKANHKTHFYFTYPGELHGFSQPAHRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y6</accession>
    <name>E8X6Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3809</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582117.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71095">
        <property type="protein sequence ID" value="ADW71095"/>
        <property type="gene ID" value="AciX9_3809"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3809"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_0"/>
    <dbReference type="OMA" id="FLANMSD"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="16879" checksum="7A7563E167063CAF" modified="2011-04-05" version="1">MNTQSRRGLLKNAAAAAAAITTGAALTPAAEAQTTGKLEKKSYPAKSNDNPAAAPPLFSSAISYGNLLFLAGVGAHFKGTVEEHTKHVLDELEKNLISAGSSMEKVLKVNVYLNDIKDWPRMNTVYAGRWGKVPPVRTTIAAAGGIPGDSLVEMDLIAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X722</accession>
    <name>E8X722_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71131">
        <property type="protein sequence ID" value="ADW71131"/>
        <property type="gene ID" value="AciX9_3845"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3845"/>
    <dbReference type="HOGENOM" id="CLU_027402_31_0_0"/>
    <dbReference type="OMA" id="WAANQGI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="94"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="41911" checksum="4EC9F0BFD28CDD48" modified="2011-04-05" version="1">MTERRACRLASQPRGTQRYRAIRREDEDALTQAIVRLASQYGRYGYRRITALLKRAGWRVGKDRVERIWRREGLKVPQKQKPRGRLWLNDGSCVRLRPERRNHVWSYDFVSARTHDGRSVRLLNLIDEHTRESLLVRAERRWSSSRVISALADVMVMKGVPEHLRSDNGPDVVAKDLRRWLAKTGAKTLYIAPGSPWENGYCESSNSKLRDEFLNGEIFYSMKELRVLAERWRVHSNTVRPHSSLSYRPPAPEAWFTPDGGYLNSEEAALTSSNGTNDRALHTKSLLSNALRKFDDSLPGEGTIRSEVGRYSSSLRWRIAHAVDYPLMKSLVDYSAEAVFATGVRERWKMRKPNGSNESAGRAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X749</accession>
    <name>E8X749_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573002.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71283">
        <property type="protein sequence ID" value="ADW71283"/>
        <property type="gene ID" value="AciX9_4330"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4330"/>
    <dbReference type="HOGENOM" id="CLU_030273_3_1_0"/>
    <dbReference type="OMA" id="HFVISQP"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="144"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="40011" checksum="F6B4FA17268E4AE4" modified="2011-04-05" version="1">MNRRLQIHNTRASAFTIPTDGPEADGTFAWDSTTLIVVEISVGGKEGIGYTYSHAVTASLALDLMQKTVEGADPFETSALFVKMRRMQRNYGSQGIAATALSAIDMALWDLKAKLLDLPLVNLLGRIREKTPVYVSGGFTTYTDSQLSKQLAGWVEQGIPRVKMKIGTHPDKDVGRVKTARRAIGAEAELFVDANGAYTRKQALDFAYTFHSEYGVNWFEEPVSSDDLAGLRLLRDQGPGGMEIAAGEYAWREFELRAMLEAGAVDVLQADATRCGGVTGFMAAAALAEAHDVPLSAHCGPTAHLHLACAAKPLRHVEYFHDHARIEAMLFDGFRSPVNGDMEPDLSRPGLGFYFKHQDAEPYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X769</accession>
    <name>E8X769_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4351</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573022.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71303">
        <property type="protein sequence ID" value="ADW71303"/>
        <property type="gene ID" value="AciX9_4351"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4351"/>
    <dbReference type="HOGENOM" id="CLU_2232751_0_0_0"/>
    <dbReference type="OrthoDB" id="1723076at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="105" mass="12269" checksum="A396A6F89F4F8873" modified="2011-04-05" version="1">MPIIGPVTDHTEIRRWADANHAVPTEVLPHDIDSEPALIRFMLAEQAKDHKDVRTIDWEEFFLKFDSLGLSFVYDDDSTGYNEILQIEERSAYRSSERNAARFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B5</accession>
    <name>E8X7B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4398</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573068.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71349">
        <property type="protein sequence ID" value="ADW71349"/>
        <property type="gene ID" value="AciX9_4398"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4398"/>
    <dbReference type="HOGENOM" id="CLU_103350_1_0_0"/>
    <dbReference type="OMA" id="INQNRMA"/>
    <dbReference type="OrthoDB" id="1597938at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="170" mass="19235" checksum="22F686DCFAF3084C" modified="2011-04-05" version="1">MAQSHIQEHIDLIARHEQEFLEKRTRSERLGDQIAAFAGSFSFVSLHLLFFLGWIVANTLNVPGIPHFDPSPYSLLATLVAVEAILLASFILMRQARMGRRADERDHLMLQILLLTEKEITAVLSMDRQIAKQMGLEKVANTTEIRELSQHTSIEDVAQTIRDTISENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L9</accession>
    <name>E8X7L9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4512</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573172.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4512"/>
    <dbReference type="EnsemblBacteria" id="ADW71453">
        <property type="protein sequence ID" value="ADW71453"/>
        <property type="gene ID" value="AciX9_4512"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4512"/>
    <dbReference type="HOGENOM" id="CLU_893607_0_0_0"/>
    <dbReference type="OrthoDB" id="2196845at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="34956" checksum="37C0D2E017D5AFA3" modified="2011-04-05" version="1">MIALSRPFTLRHPWWSVVFLTLSGVLFVLLALLPVWGWVEVRFSPVQRFYLPVYLQSTVGVLQGSGPEYVEWIEKRAPGKVWEIADPGDLVPVKEGTAPFELSKPALSQGWTELGYTAGGTFQQQETRDFLETNFFGGHSFLFLFLQPFELVLVGWMCWKFFDSWRNNLARERGLHWDPHYVPHTLGQDLELFTTQMIQEGKATASQARSWFAPKQPMVAMPAVFASRRVTVSPSETVTAEAPTPKEPEPKAASLSVTKAAEVTPDRRPKPTAPLAKPSQPPASKPPSSPFGRPPAQGEPERKWDVSQWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N7</accession>
    <name>E8X7N7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4534</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71471">
        <property type="protein sequence ID" value="ADW71471"/>
        <property type="gene ID" value="AciX9_4534"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4534"/>
    <dbReference type="HOGENOM" id="CLU_2493548_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9721" checksum="57D145D6AE509EFF" modified="2011-04-05" version="1">MDTSAFEFSALMGYPLDGFNFAIFTDRMFVESPDDFSVIDARKLSAWLLKRKCPGCAHQVDLMRAFNCDHVCFISGDLFDLGLKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P2</accession>
    <name>E8X7P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4539</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573195.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4539"/>
    <dbReference type="EnsemblBacteria" id="ADW71476">
        <property type="protein sequence ID" value="ADW71476"/>
        <property type="gene ID" value="AciX9_4539"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4539"/>
    <dbReference type="HOGENOM" id="CLU_2180134_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="12384" checksum="41E22C4E6D496E3C" modified="2011-04-05" version="1">MNYTQDTYELEITPTILPVRIPYLGYISYSIQGSDPANTGKSFLENTGNFTEVFSRIMPRPEVIGLLDQLKQGRAVHLQAVTFAQLVRLQFNFRALDPDYMAAAQPRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T5</accession>
    <name>E8X7T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4589</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573238.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4589"/>
    <dbReference type="EnsemblBacteria" id="ADW71519">
        <property type="protein sequence ID" value="ADW71519"/>
        <property type="gene ID" value="AciX9_4589"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4589"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041001_0_0_0"/>
    <dbReference type="OMA" id="QLHICYC"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="363" mass="40382" checksum="4FC33C747211239C" modified="2011-04-05" version="1">MKIAMVHDYFTQMGGAEKVAEELYNMLPGADLFATVALKDKMPESIRDVPVTTSWMQNLPRMRDLYRLYFPLYPFAVSSLDLSQYDLVVSSSSGYVKGVQVAPDAIHVCYCHTPMRWVWNFDNYSSRESFAGGVKAVLPTLIRGLRIWDEAAARQPDHFVANSQTVAARIKRAYGRSAEVIVPPIDIHRFKVSLEQDDYYVVLARLVPYKRIDLAVSACTALGRKLVVIGSGPALEGLKKDAGPTIHFAGRASDAQVEEYVSRCRALIFPGEEDFGMAPLEVAAAGRPTIAYRAGGAMETVVEGVTGVFFNEQTTEEVVDAIERFERQEWAPLAIRLHAEGFSTEVFREKFAAFLRRVGAPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X844</accession>
    <name>E8X844_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4701</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573346.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71628">
        <property type="protein sequence ID" value="ADW71628"/>
        <property type="gene ID" value="AciX9_4701"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4701"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="187"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="385" mass="43403" checksum="CDB14989EB78796C" modified="2011-04-05" version="1">MDRNRTHGGVNVIGMLRDETRLLRWGSLLYSVFWFAEPIHRRSFAVWTVFLVFYGIFLTGYLRVLRGSRREQRFWLTVLFLLGYLYYPFNPNAGGEFVFAVVVSSFFLRQGTISSAFRRFAVILAAQAAGLFLETWWLHLPWSVAQSVVFFMVVIGLSNFSFARQVFVSGQLRKANEEIEYLTQQAERERIARDLHDLLGHTLTVIAVKSDVANRLFSLQPDVAHREIAEVEATAREALHEVRSAVTGYRAEGVEAEVSKTRNALGSAGVQLYTKMDFVDLSPLESDLLCFVLREATTNILRHAYATECRVEVSKDSLIRLTIEDDGLGKQGADGNGIDGMRERLRHARGSLVIDGSPLGGMRLLAELPASLESRTRDFETGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV59</accession>
    <name>E8WV59_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix, AraC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578562.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0160"/>
    <dbReference type="EnsemblBacteria" id="ADW67234">
        <property type="protein sequence ID" value="ADW67234"/>
        <property type="gene ID" value="AciX9_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0160"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_0"/>
    <dbReference type="OMA" id="AQFIVHD"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="221"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="34958" checksum="ADA60365CAD1CD2D" modified="2011-04-05" version="1">MQIIVLALEGVFDTGLSVILDAFATATSLSAQLFGGTPRFDVTTAGVRRKVRTAQGLTVPIQAIKPASKPDWVIVPAVIAGSPAELFAKLERPDVREAQSHLLKWSAKGSRIGAACMGTFVLAETGLLDRQEATTTWSLAPFFRQRFPHVQLDDSRMVVPCDIGVTAGSAMGHLDLALWIIRQASPELAHTVSRYLTADLRSSQAPFIIPNHLAQADPMIRSFERWARQNLKDGFSLQNASKALATSARTLQRRCDAILGKSPLAYFQDLRVEHAQSLLHGEGHDVEAIAAEVGYADGATLRTLLRNRLGRGVREIRAGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV93</accession>
    <name>E8WV93_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HpcH_HpaI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0194</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0194"/>
    <dbReference type="EnsemblBacteria" id="ADW67268">
        <property type="protein sequence ID" value="ADW67268"/>
        <property type="gene ID" value="AciX9_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0194"/>
    <dbReference type="eggNOG" id="COG3836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091711_0_0_0"/>
    <dbReference type="OMA" id="IGGCEAM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="63"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="29749" checksum="CB9304C30649B96C" modified="2011-04-05" version="1">MNNRERKMLDLLNRGREEFGYVAVKAEFEAEGTRVDELLRLVEICRKADLKLGLKIGGCEAMRDLIESKQIGVDYIIAPMIESTYALSKFAEAVAKVYSAEDQEQTDFLFNLETISAFNLLDSMADATAKAPELKGIVFGRVDFSLSAGLGRDAINGPEVTDYVLKTAKACKDRGLDLVVGGGVSSDSIPVLRQMLDIHLTRFETRKVIFDANSARESNIADGLLNAVHFEMLWLLNKRDYYGQIQQEDAKRIEMLENRWAVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB5</accession>
    <name>E8WVB5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA photolyase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578618.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0216"/>
    <dbReference type="EnsemblBacteria" id="ADW67290">
        <property type="protein sequence ID" value="ADW67290"/>
        <property type="gene ID" value="AciX9_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0216"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026342_2_1_0"/>
    <dbReference type="OMA" id="RHLGFML"/>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="28"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="470" mass="54006" checksum="6D40F3FD820BFFC5" modified="2011-04-05" version="1">MPNETLQLLTQNPRVTIRRDGSPDPKGRCVVYWMQRAQRGIDNHAVNLAVEVANHLGLPLVVYFAAISNFPHANLRHYAFLNQGLPDIEEDLAARNITFLMRRAPHESHEQLLADVKAAIVIGDENPMREPERWRKTLAEKIRIPFWTVDTDVVIPSSLIEKAQYGAYTIRPRLYRLLPEYLVPYENPHAQHPWHRPKSFKSDSVHEDITMGWKDLDRSVGPVEYWKGGTHAGLAQLKRFTTKLLGDYEVQRNKPEADGTSSMSPYLHYGHLGPQTIALAVDAAAKANPKLQSARDSYFNELIAWRELAVNFVRFSSVYDTAECAENWAQKTIAEHARDEREHIYTTKQLEFAETYDTLWNAAQIQMVRHGWMHNYMRMYWAKKILEWTPDVDTAMKVCVYLNDKYFIDGRDPNGYAGIAWAILGKFDRAWGTRPVFGKRRYMSGASTSKKFDSKAYIRQMNALPEPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC4</accession>
    <name>E8WVC4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ordered locus">AciX9_0225</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578627.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0225"/>
    <dbReference type="EnsemblBacteria" id="ADW67299">
        <property type="protein sequence ID" value="ADW67299"/>
        <property type="gene ID" value="AciX9_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0225"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_0"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="127"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW67299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="40866" checksum="4C6CE5FEDC3D66F1" modified="2011-04-05" version="1">MTNQTDPTSIPTLPAYDEPTLDQSFAVLAEEVRTTAAGADAEAFRLLWLGRKQGRLKLISEAWLKQAPAEARKPLGIRFNQLKQQIEQSLEAPAAKIAAAQGLDISLPGLTRTPGIPHPLLTAMDRVVEVFHHLGYSTQLGPQVESDFYNFEALNFPENHPARDTQDTLQVAHQQSKPSRDRLLMRTHTSPVQIRTMVSQAPPLRIVIPGKVHRNDAADATHSPIFHQVEGLCVDTNVTFSDLKGTLDHAMRALFGSAVKTRFFPSFFPFTEPSADVQISCIFCGGKGCRKCKHSGWIELLGCGMVDPAVFQAVTEERRRLGLDPSPYDPARISGFAFGMGVERIAMILHGVSDIGQFYSGDMRFLEQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG1</accession>
    <name>E8WVG1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1349</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579732.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1349"/>
    <dbReference type="EnsemblBacteria" id="ADW68409">
        <property type="protein sequence ID" value="ADW68409"/>
        <property type="gene ID" value="AciX9_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1349"/>
    <dbReference type="eggNOG" id="COG2609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009154_2_0_0"/>
    <dbReference type="OMA" id="PDEYRTF"/>
    <dbReference type="OrthoDB" id="49937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="137"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="487"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="893" mass="99175" checksum="66C8802CAF5FEFA9" modified="2011-04-05" version="1">MAMKLDDAAMKDFTAEIAEWIEAFDQIVAADSGQGAEVLEALRKRASESGVAAAGTLTTPYCNTILTRNEVPYPGDRSLERRVEALLRWNAMAMVHKQNKQDAGIGGHISTYSSLATLLEVGFNHFFHGSYGEQPGDFIYFQGHASPGVYARAFLEGRFDESRLKNFRHELRGEPGLSSYPHPWLMPDFWNFPTVSMGIGPLNAIYQARFMRYLENRKLIEKTDRKVWAFIGDGETDEVDTLGAISLGAREKLDNLIFVVNCNLQRLDGPVRGNKRIIDELEGVFRGAGWNVIKVIWGSDWDALFAADKSGLLLKRMDECVDGDFQTFKAKDGAYLRKEFFGKYPELLELVKDYTDEQLGLLHRGGHDPAKVYNAYKQAVEHKGGPTVILAKTVKGYGLGSAQARNATHSEKKLADDALAAFVKRFDIPIPEQAAKDGAFYRPEQSSPEIAYMQARRKELGGYLPVRQTPKLSLRAPEFKAPSLEFFKAWTDGSKGRTISTTMGFVNLLNALMKDPAVGKWVVPIVPDEGRTFGLESSIRQVGIYAPEGQKYSPHDADMLLYYREDKDGQILEEGITEAGSMASFTAAGTAYSNYGVPSIPFYMYYSMFGFQRIGDMVWAFADSRGKGFLMGGTAGRTTMLGEGLQHQDGHSIVLASTVPTCRTYDPAFVYELAVVVQDGIKRMYEGGEDAFYYITMYNEDYVQIPMPEGVAEGVVKGMYKIKPALKGEAALQLFGSGPILNEVLKAQEILSEKYKIEADVWSVTSYVEVRREALSVERWNRLHPAEAEKKSYLETLMDGTKGPIIAASDYMRSVPDSLAPWLDSRLVSLGTDGFGRSDNREHLRTHFEVSAAAIVGATLSRLVREGSFKAKDAQKAMKELGLNSEAKDPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR9</accession>
    <name>E8WVR9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580913.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2571"/>
    <dbReference type="EnsemblBacteria" id="ADW69598">
        <property type="protein sequence ID" value="ADW69598"/>
        <property type="gene ID" value="AciX9_2571"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2571"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_4_3_0"/>
    <dbReference type="OMA" id="RWWFDHA"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234084" evidence="1">
        <location>
            <begin position="22"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="75"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="540" mass="57796" checksum="DB2BF471164D266B" modified="2011-04-05" version="1">MNRFLFTSLATALLVASTAGAQTPSAAPDLVLSNGHVFTGDKANPWVEAISIRGERIVLAGSDAAVMATAGTQTRVIDLHGRMAMPGINDSHDHVGGADFGVQLHSPPGNGPHGPGPEPSVAELADAVKAAALTAPEGGWIEGEVGEAIIRHPRETRQALDEAAGYQPVIVSSWWGHGAILNSRGLAKLKLTDAVKDPEGGHFDRDAAGHLTGLLEEEAANEVKRGLADEAGVEPSVKAFHGYAQRRLEQGVTTVQIMATNQRLSYLEKTFAQPDDPLRIRIMRFPMALEDARVGEKLGTGEEVLNPRVRVAGVKYVLDGTPIEELAYQTKDYADKPGWRGRPDYSVAFIARQLKLALNGKDQLMLHIVGDAMTDEVMDEMEKLAPAETWRPLRVRFEHGDGFTTPERMARAHKLGIVIAQPRPGRPWKALETAGIPLAYGSDGGMSPWLMFSVMTDAKNPQAISTDDALAILTSGSAFAEFQETKKGRLAPGMLADVAVLSQDVTTHPQAPVPATHSVLTIIGGSVAFRSAELGMQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW5</accession>
    <name>E8WVW5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3723</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582033.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3723"/>
    <dbReference type="EnsemblBacteria" id="ADW70724">
        <property type="protein sequence ID" value="ADW70724"/>
        <property type="gene ID" value="AciX9_3723"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3723"/>
    <dbReference type="HOGENOM" id="CLU_1007473_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234089" evidence="1">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="30681" checksum="DF631FC0A0BAB908" modified="2011-04-05" version="1">MKHSLLALSFLIASMAHAQYGVRRTVYHPEKLLPDVPVTAPDAAFPLRVHLFNVRWGGLGSRNHGYGTGNLLDAANLQGFDFAFECGVPFTPNADPADTYQARWKKSPYQLEILTTEAGASFTRTCTLNLAMEARPFTTANDAHFSHGVSSSLRTPWLDPGFAYEGPSTDHLIQFHVLDGQRQEDSFGDHGWGIANLVDPQPGSVLQGADYRFDCSRGFVTSSQLDNYYQGRWTRPGQKLELLLQRPGSDKVDRCTVSVALRPDPYPERRSRAQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ1</accession>
    <name>E8WVZ1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3750</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3750"/>
    <dbReference type="EnsemblBacteria" id="ADW70750">
        <property type="protein sequence ID" value="ADW70750"/>
        <property type="gene ID" value="AciX9_3750"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3750"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407630_0_0_0"/>
    <dbReference type="OMA" id="IQSGRWR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233907" description="ASH domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="682"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="4">
        <location>
            <begin position="508"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="776" mass="79502" checksum="C28B1BCA04CC8035" modified="2011-04-05" version="1">MRILCASLLVLFGLSVPAAFGQTTSISGIVYAPNGKQPLPNVLVYVPTTAVDAFTPGVSCPVPGTPPSGTPLVGTTTATDGSFSLGGVPIDPAVPLVIQSGRWRRQVTIATAAGVNTVVDPNLSRFPRNQTEGDIPKFAVATGSQDQVECVLRKVGVDDAEFTNMGGTGRINLFSGSGSPGARIDSATPSQVNLMTDSTVLNQYDVLMLPCQGNQYIQPAGSLANFVSFANAGGRVYSSHYSYVWMYNNAPFNSVVNWKVTQPDPGTTGTATVDTSFSQGQILSNWLQLVGATTTLGQIQLSVLKHDLNGVVAPTQSWLTLNNTALNNPVMQFVFNTPVTTTTNQCGRVLFNEYHVEQPTTSPINVAFPSECPSATTDLTPQEKLLEFSLFELTSDGSAATLTPTSQDFGSEPVGFTTAAKPFVWTNNSTFPAAVTIQAASGDFSVVSPACGTVASGASCTINVVFTPTALGARTGTLSVGSGTTTLTASLTGTGVPALALSPTPTPSSSTTSTSLDFGSVDVGATGARTLFLTNSASGGLPFPQLTLTGPYSVSSNCTSIVPANGSCTLTVTFHPTTTGASPGSITISSAAAVGPTATAALTGNGVDFTFVVTPASGNIIAGYPVTLSSLTSPIAGFANPVTLSCVTNAPATTCTPKSATILPSAPITTEIDLATTSQYTVIGYSGLGGNWLLGALAIGTGSLLWFRRRSASTLARATLVALLLAVASLSVTGCSGKLPAENSSYTKPGSYSFTITATDGFLVHTATYNLTVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW69</accession>
    <name>E8WW69_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1393</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1393"/>
    <dbReference type="EnsemblBacteria" id="ADW68452">
        <property type="protein sequence ID" value="ADW68452"/>
        <property type="gene ID" value="AciX9_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1393"/>
    <dbReference type="HOGENOM" id="CLU_1978400_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13081" checksum="6D5C42EB3F27DBA6" modified="2011-04-05" version="1">MALQKNPASRSSTFRWIVSSLLCLLALVIAVVPCSAAMQPTASMMAMPPAAHCAECCPQSTQSVAALCCVAPLPPAQQISLASYALPAPSSNLTTALPTLTMKTDAPSQASASIQLRPPLHPILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ6</accession>
    <name>E8WWJ6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6321 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2635</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580975.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2635"/>
    <dbReference type="EnsemblBacteria" id="ADW69660">
        <property type="protein sequence ID" value="ADW69660"/>
        <property type="gene ID" value="AciX9_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2635"/>
    <dbReference type="eggNOG" id="ENOG5033YIC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1784138_0_0_0"/>
    <dbReference type="OrthoDB" id="1957438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046284">
        <property type="entry name" value="DUF6321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19846">
        <property type="entry name" value="DUF6321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6321" evidence="2">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="145" mass="15267" checksum="F1EC111465B25994" modified="2011-04-05" version="1">MATKKTSAKKTSAKKTAAKKAPAKKIAAKKGAGKPPSRKSVSLTKEGKDPKGGLTAAGRKTYNDATGGHLQEGVKGKADTPEKKRRKGSFLTRHFTTPPGPVVKDGEPTRQALQAAAWGEPVPKTEAEEKKLAAKGRKLLAEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM5</accession>
    <name>E8WWM5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3770</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582078.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3770"/>
    <dbReference type="EnsemblBacteria" id="ADW70770">
        <property type="protein sequence ID" value="ADW70770"/>
        <property type="gene ID" value="AciX9_3770"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3770"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114582_0_0_0"/>
    <dbReference type="OMA" id="ASAWNTI"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26067" checksum="CD9889FF2CF3B079" modified="2011-04-05" version="1">MKASALEFRLRYLFHGIVYVLAFWSPWNYALHTDPTGPNAHVWGVLSAALAKNGILNIGAAFDLLLVIGILCAFTGAGLRTWGSAYLGSGVVQDGRMHAGVVADGPYRHLRNPLYLGTFIHTFALALLMPQSGAIFAILAIGIMQIRLIFGEEAFLAGSLGDPYLAYKALVPRLLPSIKAKVAASGQPARWGQAFLGEIYMWGVAGSFAFAGWRYNASLLTQCVLVSLGVSLLTRALKPNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP3</accession>
    <name>E8WWP3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ordered locus">AciX9_3788</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582096.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3788"/>
    <dbReference type="EnsemblBacteria" id="ADW70788">
        <property type="protein sequence ID" value="ADW70788"/>
        <property type="gene ID" value="AciX9_3788"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3788"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143559_0_0_0"/>
    <dbReference type="OMA" id="KHADYQR"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14832" checksum="83A0DED1483525CD" modified="2011-04-05" version="1">MPTPTPNALLRLRKHADYQRVYTSSRKQFSKQMSFFFSIRPEGRRSDTPGPRVGLTVGKVLGKAVDRNRIKRRLRECVRHHAQTLTHPVDVILHPRRTVLELESGHLEREIAQIFRTIQTTLNKAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWW7</accession>
    <name>E8WWW7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1475</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579848.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1475"/>
    <dbReference type="EnsemblBacteria" id="ADW68528">
        <property type="protein sequence ID" value="ADW68528"/>
        <property type="gene ID" value="AciX9_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1475"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972422_0_0_0"/>
    <dbReference type="OMA" id="QFDIETH"/>
    <dbReference type="OrthoDB" id="1105246at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230012" description="DUF4097 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="98"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="29466" checksum="C7A12B730BC7BFAB" modified="2011-04-05" version="1">MLIRALALSSALLITVSAHADGNFDRTVTVNGQSDLYVSSNSGHIHIYPGSDSEIHIKAHLKAGGWNHSEGGDVEDRIRRIVDNPPIQQSGNTIRVGNVSPEDRKLFNNISIDYEISAPKSVALNLHSGSGDVDVDNLGRFLKADTGSGSVRAHGIGGPSDLHTGSGDIELQQQAPGEVKTSTGSGSIRINGLNGSLQAHTGSGDIEANGSLTGPATLQSGSGSIRLHIGRDAHFDAEASTGSGSIRISQPGAPQGSDERHHVSASINGGGPSLTARTGSGDIEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX5</accession>
    <name>E8WWX5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1483</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1483"/>
    <dbReference type="EnsemblBacteria" id="ADW68536">
        <property type="protein sequence ID" value="ADW68536"/>
        <property type="gene ID" value="AciX9_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1483"/>
    <dbReference type="HOGENOM" id="CLU_3099375_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5485" checksum="DD0F6A7EC7EE41D6" modified="2011-04-05" version="1">MKDGSRQDVTGVPGALALINFYLLLSVNPSGVLGWIGERIELIKIDQSDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX33</accession>
    <name>E8WX33_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1541</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68594">
        <property type="protein sequence ID" value="ADW68594"/>
        <property type="gene ID" value="AciX9_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1541"/>
    <dbReference type="HOGENOM" id="CLU_2117566_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="12310" checksum="0766B2D6F91A7C36" modified="2011-04-05" version="1">MGVYAPILSSMYEIDKDGNLRDPKGAEYFPRGSFTFYTAPTPPNGTPAHYPTTGFAGLIEIQIVPGLQVFNPVIPGLPNTTVLSPRELNNAGVAMFVVGVFYTPPKKPAQPPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC3</accession>
    <name>E8WXC3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0384</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67456">
        <property type="protein sequence ID" value="ADW67456"/>
        <property type="gene ID" value="AciX9_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0384"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808365_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="38209" checksum="E0F37380A08FE41C" modified="2011-04-05" version="1">MPRPASCYEVLIASPGDVLAERQIIVDCIEDWNAAHSRSTNVILQPRRWELDVYPEMGDRPQEIINKQIVDNADILFGVFWHRAGTPSGVAQSGTIEEIERSVDRKKLVFLYFSQAAVPMTHDAAQLAAVQDYKGRMRQRGVAFDFPDVHEFRRMVSRHLAIKMNVLLEASGASQETTAPEENNLARVRVRVGQKGRNGEVTTINVIGELQNLTTSTRIREYGCQLMVPAALLKFASVNYMAEVKSERAGIRVFRHTEANFSNTPIFPGDSLQIVSVEIAIGHLEMKELTGLIRQEAYDLTMNGVIVAEATVDGKLLRAEKPIREIFSLAGGSGRVSSRSIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC9</accession>
    <name>E8WXC9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0390</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578790.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0390"/>
    <dbReference type="EnsemblBacteria" id="ADW67462">
        <property type="protein sequence ID" value="ADW67462"/>
        <property type="gene ID" value="AciX9_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0390"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_0"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="414" mass="44166" checksum="8A5E482DAE4CD5E1" modified="2011-04-05" version="1">MSESLLQTQAITLTDVLAARERIRSSVYYSPCPRSEMLSNLTGQQVHLKLENLQMTGSFKERGALNRLTLMTPEERSRGVVAASAGNHAQGVAYHSTRLGVRSIIVMPLATPLVKVTATRNFGAEVILHGANYDEAYAEATRICEAEGMVFLHPFDDPAVMAGQGTIALEMLEQVPHLEAVIVPIGGGGLIGGIATAIKESNPNIRVIGVQTSRLPSMSAAITAGHPITIDAATTIADGIAVRRAGTLTYPVIARYVDEIVTVDEDEIASAILVLLEREKTLAEGAGAAALAALLQGKTSLGTRSGVNVGVLVCGGNIDVTLLSRIIERGLVQDGRLILLRIHLLDKPGALADLTKLIASHRANIVNTLYNRAYYGVNLGDTVIDITMETRGKEQVAELLGALTREGYRHSRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE7</accession>
    <name>E8WXE7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0408</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0408"/>
    <dbReference type="EnsemblBacteria" id="ADW67480">
        <property type="protein sequence ID" value="ADW67480"/>
        <property type="gene ID" value="AciX9_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0408"/>
    <dbReference type="HOGENOM" id="CLU_2167397_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12089" checksum="3EFEC9EEDA99A079" modified="2011-04-05" version="1">MKRYPAPPIDPMIIERARELKEAGASQEEVFMAMRQDGLWVGQSIKVAAEIYGWSLTEAKMTVHYSDTWADCLQTNAKLHDAAFAAAKELGFEEVGSGVNGEKVALQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN7</accession>
    <name>E8WXN7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1600</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579972.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1600"/>
    <dbReference type="TCDB" id="9.B.8.1.5">
        <property type="family name" value="the duf2157 (duf2157) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68653">
        <property type="protein sequence ID" value="ADW68653"/>
        <property type="gene ID" value="AciX9_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1600"/>
    <dbReference type="eggNOG" id="ENOG502ZB8Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854528_0_0_0"/>
    <dbReference type="OMA" id="FSVHWEL"/>
    <dbReference type="OrthoDB" id="1140765at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018677">
        <property type="entry name" value="DUF2157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09925">
        <property type="entry name" value="DUF2157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2157" evidence="2">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="35206" checksum="67AA18EEC2244A23" modified="2011-04-05" version="1">MTILSRIRDWKDQGNISPDQEALLTNLALEQPFSLSLELNVLLYAGVLAFVAGLGWTISTWSQQLGTLAILTALTLILAASLWFCFARVPTWSPAETSASSPFVDYVLYLACLVWSLELAYVEQRFHLLSGQWDLYLLLTAALFFALAYRFDNRFVLSLALSGFAGWFGLALSHGPLEDLEGRLRPYALLYCLIVGAGTVLLQHFKLKPHFFGTYLNLVANVLFWTTLSGVFEHENYGLWVIGLLATCGASLAWGLNRRQFVFVAYAAVYGYIGISSLIIRNSNDAIFILGYFVVTAIAMLVMLVKISQHFWRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXW8</accession>
    <name>E8WXW8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="8" type="ordered locus">AciX9_2790</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581128.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2790"/>
    <dbReference type="EnsemblBacteria" id="ADW69813">
        <property type="protein sequence ID" value="ADW69813"/>
        <property type="gene ID" value="AciX9_2790"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2790"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_2_0"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="209"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="473"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="659" mass="72998" checksum="8F06BCA69F1A0D9A" modified="2011-04-05" version="1">MGRIRILSDQVANQIAAGEVVERPASVVKELLENSLDAGATRIRIEVEAGGRKLIRIVDNGHGMGKDDALLAFERHATSKLRTSDDLLSIATLGFRGEALPSIASVARLSLETRAAEDDSGTHIEIAGGNILTVEDAGLPIGTTIAIRDLFFNTPARRKFLKSESTELSHIAALVTHYALAHFNRHFELHSTTQALLVAPAVASAGDRLFQIFGRDTAALMIPTTAEMDFTRAGLPEPPPWKRELDYEAPDPGFLRISGFVSKPELQKLNRNSVYVFVNQRLIRDRLVLHALTEAYRNIIPPSSFPVVLLFLEMPPHEVDVNVHPAKTEVRFRQPAFVHDFIRDTVRTTLMQARPAASFASALNGAPYNDAHSSLLIDVSPLPGAPSDPVFDPRRAPEGFPQSDHDPSHEDSAPFFLAPIPVPESPGRLDFSAAATLAVGYEQEAAHAPEQVDYGKDRVIENPSLYSLSTLKPLGQIRDSFILAVNDEGLWIVDQHVAHERILFEKILRERNTEQIQRQRLLMPLLIDLMPDQMVAFARIAEELERQGFEAEPFGPRTLAVKSAPVGLEGRELEQMIEDLLSVEDRIGQTENADTRARRIAASMACHAAVKINMPLERSKIDWLLAELGKTEYPTSCPHGRPIALRYSHKEIEKAFQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXY3</accession>
    <name>E8WXY3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0450</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67522">
        <property type="protein sequence ID" value="ADW67522"/>
        <property type="gene ID" value="AciX9_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0450"/>
    <dbReference type="HOGENOM" id="CLU_3389677_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="32" mass="3592" checksum="BE32F57053F16FFD" modified="2011-04-05" version="1">MRAGMGWGYVTDENTGGRVEAILFFEWGEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY50</accession>
    <name>E8WY50_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1625</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579996.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1625"/>
    <dbReference type="EnsemblBacteria" id="ADW68677">
        <property type="protein sequence ID" value="ADW68677"/>
        <property type="gene ID" value="AciX9_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1625"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013589_0_0_0"/>
    <dbReference type="OMA" id="GNENYPW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="622"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="839" mass="92346" checksum="A5F12BAA65F431A2" modified="2011-04-05" version="1">MKRRIISHYEFVRKIGAGGSGVVFLATDTLLQRPVVLKLLKRGALTAEQVRTTQLREARLASAIDHPNVCAIYEVGEVPAESGDGAEAYIVMQYIPGQALDKLIAAGPANLQLVLSAGIQIADGLAAAHSLGIFHRDLKPANVMLTEGGLIKILDFGLARRLNLDETEFDPSGNSGTAGRRPVPPPGATYTARGGTIAYMAPEQFVTGQSSVQSDLFALGLILYELVTGRHPFHRPDAPEFQSIRAIQFADPTPPREINRNIPIELQSVILRCLEKQPSARFASAADLREALKTIMMAHQLDTVGPPGESVTLLPSQRPPAVETPEEEKRTTGILSMLAERFRESGPTATTAKQNTLVVLPFINFGTSSKQNESQPSPLYGYALADALAARLARMPSLIVRPSSSLATIPTHQLDPLAIGRKLLVHYVLAGNFLRSDQGFDLNWQLLDVNGQSVRTGGSISVASFDLVAVQTEISNEVFSTLQGIGGLTTSHHAAQPSSLSQDNSEDYLQARAVLSSFMSRTGSREDLDRARELFESVTTQDVDFAPGWSGLGITHLQYASHGLGGQMHVLEARRAFDKALQLDPGSVESNLYRVYMLLSRGEKESARHGIENLLQSAGNDWNVHLVAGQTLRIDGMYEEALEQFNTALRLNPSNAALIYNNRARVFQYQNQLELAADELEKGLTLEPKQPLLRISLGYQQMRTGDLAKAIETLEKVTSEEKSLRIVYPTIALCYVQLGDREKAATFIVDETLSAAEADSEMAYRLATYFALEGDESEALHWLRRAIYLGNENYPWFSINPAWRKLGGHGDFERILEDLKKSFRKNQKNWRRLLAQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE2</accession>
    <name>E8WYE2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581163.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2825"/>
    <dbReference type="EnsemblBacteria" id="ADW69848">
        <property type="protein sequence ID" value="ADW69848"/>
        <property type="gene ID" value="AciX9_2825"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2825"/>
    <dbReference type="eggNOG" id="ENOG502ZZF9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1238762_0_0_0"/>
    <dbReference type="OMA" id="NDRRKFN"/>
    <dbReference type="OrthoDB" id="2048823at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="23849" checksum="EC23BB51C831678C" modified="2011-04-05" version="1">MSDKPLPFVINDRRKFNSEGELRPESERAPDPEPTPKAPTPISEPEQHPAPHLVTETSEETTEVTAEEAEDPNLPPPPTAEQMEQARLAFEATAERLEIAIRSANPGMDHPPAMSFEQIVQSVYMQSIMQLGGGAQEGQQPQVDILGAKQSIDMLAVLSAKTAGNLAESEQHLIDSALFELRLAFLEITQALARSAQARATQGPPPGGAPTPGGRPGPSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP5</accession>
    <name>E8WYP5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0572</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578971.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0572"/>
    <dbReference type="EnsemblBacteria" id="ADW67643">
        <property type="protein sequence ID" value="ADW67643"/>
        <property type="gene ID" value="AciX9_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0572"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_0"/>
    <dbReference type="OMA" id="WWGEGRI"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="182"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="56451" checksum="A2A0E0E6D2FE3FB5" modified="2011-04-05" version="1">MIILYHPRATRPRNRRLPLAVLALAAALEGTEDYEIVDGNLEDDPTGRILELIGQHHVELLGVSCMPGPQMVAAMETSREIRRLHPEVKICWGGYFPSLYPDAALNARYVDYVVRGQGEDTLLELMEAIRGKRELTSIKGLLYKDMFGLRHDNGERAMKGPDEFPWSPFHRLPVEKYLRPSFFGKRTAVHHASIGCPFNCSFCGVHAAYGNKEKFESPERTVAILTHLVDRYGADSVQFYDMNFFLREDKARELCDRMAHLNLRWWCEARVDIMSRYSDETWAAIKRAGCAMIFFGAESGSDWVLEEMQKGITTEQTLEIARRTYEFGIIPEFSFVIGNPNDPDRDTQESLRFIRKIKRINPDSEIIIQHYTPTPQPHKAGGEMYGDIEVPFPDTPAGWATEEWMNFTLRIDTNAPWLKQKTKKLIDNFETVVGSRWPTVQDIRAPQWSRLLLKALSAWRYTFHVYKHPFELHLAQQFIALRKPKRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ1</accession>
    <name>E8WYQ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0578</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578977.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0578"/>
    <dbReference type="EnsemblBacteria" id="ADW67649">
        <property type="protein sequence ID" value="ADW67649"/>
        <property type="gene ID" value="AciX9_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0578"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_0"/>
    <dbReference type="OMA" id="FWTNIFT"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="185"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="509" mass="57506" checksum="FB52C6D6855E5F52" modified="2011-04-05" version="1">MQRSTQPSKKIVFFFPSFASSEATAPLGILAVATPLIRAGYQIVLIDSTITPNYKKRVLEEVRDAVCLGISLVTGPMIRETVEIATAVKEWNPDFPIILGGWHPSLLPDQTLQAACVDYVVRGQGEDALLELVQHLQTRSAPDLIPGIGFKRGGKLILTPERPLRPLVDMPPKAYQIADFDAYERGCGKRWAMYTSSLACPFNCSYCTNAGVYGRKWNALPPEQFVEETVDLTRRYQLEMLWVVDDNFMVDLDRARGIAEGLVRAGSQFKWSVQATSNMVARLTHEDLKLLRRAGLHQICQGVDSGSTKVLQLMGKTFQDFDQIYESAARCLSADIRPSFNIIFAFPGEGRKERRETIDFMMDVCRRFPGAEFWTNIFTPYPGAPIMQRAQELGIEVPKTLEGWADFFPRYTTLPWLKGKDHTRLQVTRDYLRIAFDRIPIGSDTRDPITRIVQKSLSLPARWRLDHDTYKFPVEIWLNNKLNERLGLARSKPAVDAKRLATTPAEAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ11</accession>
    <name>E8WZ11_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2903</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581241.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2903"/>
    <dbReference type="EnsemblBacteria" id="ADW69926">
        <property type="protein sequence ID" value="ADW69926"/>
        <property type="gene ID" value="AciX9_2903"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2903"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277395_0_0_0"/>
    <dbReference type="OMA" id="CADVETC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233506" evidence="1">
        <location>
            <begin position="33"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="332"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="427"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="518"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="611"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="703"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="2">
        <location>
            <begin position="904"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1143" mass="116032" checksum="96C4D02C4CDCA4E2" modified="2011-04-05" version="1">MFRLCPILVLRRTLRTRLLLLPVACGALVCQAQTSHPLFPKTCVPLQATQRSVDGVFTAQPYEETALIQSALDACPAGQSVELTPAPGPNAGGRQNTFLTGPLTLPPGVTLLIDAGVTVYAAPKPDEARPIITIAPSPIPAGLMGFGILDARGASPTLIDAQGALTIFKLTLRNAPGITVRYASISGLHIEGAKIAGTQAIVLAPDAAKVEILHSTISTAANLPTMTGELYATDPTTSPAEALTTKSPITLSAVLIPPDPTFPIAAPGSQVVFYDGPIQLGTASISDTLAQLTIPPPAIGTHHLTAFYPDANLSFGSVTIVVPQMTLEATGTTVYARAPITFTATLDQPTATGSITFTDTATPLAQSPLSQGVATTTTSALTVGPHTINATYPGDTSDTPAQSPDLPIQIDPNPTITALTPLTTGQPYGTPLTLTANILPADAPGLITFRDTTTQTQLGQAPVSQGKATLTNITNLSVGTHTITASYPGDTEDLPSISAPVTTIVTGIATTSSLSATPTTTTYGTPVTLAASITPAASTGTITLTDSLTGTTIQLPLNSGTATYTPTSLPPGTHVFTAAYSGDATHAPSSSPSIAIQVNRIPTSTLLTGLPATIPQGAQPILTATIAPTSATGIVSFLDANSGLLGQSTLTNGSATLPLPPLNPGPHTITAIYSGDTDDTTSTSPSLTTQVPLNPTILALAAPTTITFGDTPTITATVTPTTATGLITFTDSTTGPIPPALLANGTATTRLPILQPGRHILTATYSGDPADSPSTAPPITLTVLPAASTTTLSLAQSNIPAGVPVTFNIQVTSVPAANPSGQIVIRGIAPTGPITFATTTLTNASAAHAYATVSIDSTPLGLGTFTAVTASYAGDPDDSPSTSTPTTFQIIPTPVAATLTLSSNQIPIGTPITLTAALTSPAQPPTGTITFYKDGLAIATIPTTNATASTTLTPQALGTELFTATYTPTGLFAAATATPQFLTVTPPFSLALTPTTLTQTAPSSATSTLIITPLSGYSGPITTTCAVPQPYFTCTIDAPAPLANSTPSIAVIHLAVAANILPPKTASLTLKTPFTITLALLAPIFFRRKKHLCLLALTFLSLSITACAPGTFFDIPLGSNAILLTVRTPTASISTTLTVNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ44</accession>
    <name>E8WZ44_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ordered locus">AciX9_2936</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581274.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2936"/>
    <dbReference type="EnsemblBacteria" id="ADW69959">
        <property type="protein sequence ID" value="ADW69959"/>
        <property type="gene ID" value="AciX9_2936"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2936"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_0"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17382" checksum="3E9909B84051DE54" modified="2011-04-05" version="1">MAIRNLSNLRAPKKANENKKRVGRGMGSGMGKTSTRGHKGQGSRSGSSLMRGFEGGQMPLHRRLPKRGFTNIFRVEYTVVGLDRLAELNAANNETEFTLDKIVELGLRRRKNSLIKVLNNGEISAAITVHAHKFSKTAKEAIEKAGGKAVVIGEGADEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH2</accession>
    <name>E8WZH2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ordered locus">AciX9_1812</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1812"/>
    <dbReference type="EnsemblBacteria" id="ADW68860">
        <property type="protein sequence ID" value="ADW68860"/>
        <property type="gene ID" value="AciX9_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1812"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_0"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="26315" checksum="5575D62E0A121849" modified="2011-04-05" version="1">MNTDTEIFDAAAFTQQTLTSTASLAAVLDHTLLRPDASRAQVLQICHEAAEHRFACAMVNPTWVATAHEALAGTGIHVGVVIGFPLGATLSGSKRDETVRVLKHGAHDVDMVLNIGLLKSGTKEDYEAVKQDIRGVVELAHASGAIVKVILETCLLTFEEKLRASELALAAGADFIKTSTGFSTGGATADDIMLMRGVAGTRAGVKASGGIRNLADARLMLESGATRIGASASVRILAELAGHTPTTPAPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ9</accession>
    <name>E8WZJ9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplV</name>
        <name evidence="11" type="ordered locus">AciX9_2950</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581288.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2950"/>
    <dbReference type="EnsemblBacteria" id="ADW69973">
        <property type="protein sequence ID" value="ADW69973"/>
        <property type="gene ID" value="AciX9_2950"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2950"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_0"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="18508" checksum="53623CEE38C5CA1E" modified="2011-04-05" version="1">MAKSEVKIQEFRAEAKFQRTSPQKAKLVLDMIKGLRVEQAINTIHFSTKRMAPVVEKVLRSAIQNASYVSDEKGLDVDVDNLYVRTAIANEGPRMKRIRPAPMGRAFRYQRRLCHIIVTVAEKGKTIEAKAPVVPETKAAGKPKKAATKTAAKKAPAKKAAAKKTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZZ5</accession>
    <name>E8WZZ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68891">
        <property type="protein sequence ID" value="ADW68891"/>
        <property type="gene ID" value="AciX9_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1845"/>
    <dbReference type="eggNOG" id="ENOG5033ZMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830964_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="37757" checksum="C14AD737CF792E2C" modified="2011-04-05" version="1">MTNETTASARYQCRHIHTDGRRCGSPTLRHEHFCYYHHTTRKPIPRADLEARYADQNRCAPFDLPIPEDRAAIQLAIGEILRRIAANQLDNRRAGLLLYGLQIAATNLPPQRQPATEPKAERELVEDTVQDPTHGTLAPEAEYAAPKGEKTLEQILKERWAEDKEAAAEKARLHPPAPERPDYVWSDEEEGLVLKAVAETIVAATSPKPAPTKSALVAFIPCYPRNLSPGTSTISSTLIQPSLRVQRSPSLRKVILRQQRSQPQARTQQPGLRRRLRNPHRRSHLLHRHIAPMPSHNDVPQQRRQLAHRLAQLPHLLQPQAHRLGTRGRIGQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X074</accession>
    <name>E8X074_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3035</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3035"/>
    <dbReference type="EnsemblBacteria" id="ADW70055">
        <property type="protein sequence ID" value="ADW70055"/>
        <property type="gene ID" value="AciX9_3035"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3035"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_0"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="208"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="441" mass="48260" checksum="7C9057768FF46670" modified="2011-04-05" version="1">MARESLIPATEKRETKMPAIANILTLEQEKNPWEAQAARFDLAARKLNLDNGIWKVLRMPTRELIVHIPVAMDDGSIEVFTGYRVQHSIARGPGKGGIRYAPDVSLDEVRALASWMTWKCAVVNIPFGGAKGGIICDPKHMSQGELERMTRRYTAAIIDFIGPEKDVPAPDMNTNEQTMAWIMDTYSMHMGQTVTAVVTGKPVNIGGSRGRREATGRGISVVCDQALKHLGMDIAGTRVIIQGFGNVGSNAAHLLYKKGYTITGIAEYDGGLYNADGIDIPALIEHRAKAGTINGFAKAEAADKAELLTRECEILIPAATENVITSQNAADLRCKILCEGANGPTTIVADDILEDKRVFVIPDILANAGGVTASYFEWVQDRMGYFWTEAEVNQRLDAIMTESFTDVVSYATSHKVNNRIAAYMLAIDRVAYTTKQRGMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X088</accession>
    <name>E8X088_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3049</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581383.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3049"/>
    <dbReference type="EnsemblBacteria" id="ADW70069">
        <property type="protein sequence ID" value="ADW70069"/>
        <property type="gene ID" value="AciX9_3049"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3049"/>
    <dbReference type="eggNOG" id="COG1982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014292_3_0_0"/>
    <dbReference type="OMA" id="MKGRSGE"/>
    <dbReference type="OrthoDB" id="485164at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008923">
        <property type="term" value="F:lysine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1_N" evidence="6">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1" evidence="5">
        <location>
            <begin position="145"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="7">
        <location>
            <begin position="627"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="805" mass="89873" checksum="B2C3D50A44ED5218" modified="2011-04-05" version="1">MSEGRWVLLIASEVGGTDSVSDRAMERLVSAIGEEGYEVVRTSTPEDGLSLITSDPSYSSILLDWDLEGDNQFQEREALQILRAVRRRNKKIPIFLIADRTLVSELPLEVVRQVHEYIHLFGDTPAFIANRVDFAVERYHETLLPPYFKVLKKYTDEGAYSWDAPGHMGGVAFLKHPIGMEFHKFFGENIMRSDLGISTAPLGSWLDHIGPPGESERNAARIFGADWTFYVLGGSSNSNQIIGHGVIAQDDIVLADANCHKSICHSLTVTGARPVYFKPTRNGYGMIGLVPLKRFSPENVKSLIDKSPFTPGAPSKEPTYAVVTNSTYDGLCYDVNRVVQELSKSVPRVHFDEAWYAYAKFHPIYRGRFAMDVPDDMPDRPAIFSVQSTHKMLAAFSMGSMVHVKLSQRAPLDFDQFNESFMMHGTTSPFYPLIASLDVAAAMMDEPAGPTLMDETIQDAISFRKAMSSIAHRLRLAESNGDGWFFRLYQPEVVIDPRTDESFVFEEAPDSLLGTASSCWTLKPGEDWHGYQDEDIADDYCMLDPTKVTILTPGVNPQGKISEWGIPASILVEFLDSRRVEIARVGDYTVLVLFSVGTSKGKWGSLLENLFEFKRLYDSEAPLEEALPELVSKYPARYRNVSLKELSDEMHSVMGDLDLAGLVNAACDEDFDPVLTPAQTYQKLVKNQTERIRFNEMAGRLAAVMLVPYPPGIPMSMPGERLGSSESPVIKLILAMEEFGKRFPGFEREVHGIEVDSDGNYWMRAVIEGAEGKPKKRKGKKAPPSNAPPVHKQRLKSKPIRRSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F4</accession>
    <name>E8X0F4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0748</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0748"/>
    <dbReference type="EnsemblBacteria" id="ADW67818">
        <property type="protein sequence ID" value="ADW67818"/>
        <property type="gene ID" value="AciX9_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0748"/>
    <dbReference type="HOGENOM" id="CLU_2368926_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10147" checksum="88EBB3BB7A896895" modified="2011-04-05" version="1">MKVQSLANEPIPKAYKPWMILSTAVLIGSLVLFAVDAVGAFLSFGDKTTPLWVIVVGVLAVFGVFLGFGGLFVLLATAGFQAWRAGRRVQVLPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N2</accession>
    <name>E8X0N2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1937</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580302.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1937"/>
    <dbReference type="EnsemblBacteria" id="ADW68983">
        <property type="protein sequence ID" value="ADW68983"/>
        <property type="gene ID" value="AciX9_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1937"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_0"/>
    <dbReference type="OMA" id="APHIRRY"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="33867" checksum="31DD5E645A519ECB" modified="2011-04-05" version="1">MTTQTNSHFMASDVPSQQGRRVLITGANSGIGYEAALELARQGAEVILPARSVDKAEGAIARIRREVPGAKLTAGVLDLASLASVREFARTIGERFPGQSLDLLINNAGVMAVPQRELTVDGYERQFATNYLGPFLLTALLFPQMRQRRGSRIVTVSSGVSNQGKIEFDNLQGERSYKPMFGAYSQSKLADLIFQLELQRRLTAVGSPVLSTGGHPGYAITNLQASGPAGQSPLGFRIISAILKPFASQDAAHGALPTLYAATAQSVEPGGYYGPNGFQELKGYPVAAKIAPAAKDLSLAKRLWAETERLTGVTFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P5</accession>
    <name>E8X0P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1950</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580315.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1950"/>
    <dbReference type="EnsemblBacteria" id="ADW68996">
        <property type="protein sequence ID" value="ADW68996"/>
        <property type="gene ID" value="AciX9_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1950"/>
    <dbReference type="HOGENOM" id="CLU_2522890_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9334" checksum="CB270C26797571C5" modified="2011-04-05" version="1">MTLLTALQERHDEVVERLTVEFVRLGTEAAVREWVFQDDGPVELVADMTGLGLTDADAEAVFVLLDDLCRLAAGRAGFLEWLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T8</accession>
    <name>E8X0T8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581436.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70122">
        <property type="protein sequence ID" value="ADW70122"/>
        <property type="gene ID" value="AciX9_3105"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3105"/>
    <dbReference type="eggNOG" id="COG4634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141039_0_0_0"/>
    <dbReference type="OMA" id="NNARDFR"/>
    <dbReference type="OrthoDB" id="1805280at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="15102" checksum="7ACEA9DF4104F02F" modified="2011-04-05" version="1">MQKLLIDENLSPSLIGQANDKGFVCSHVNYLGLTGRKDWELKAAILDGDWTFITNNGVDFRGPAKKPGSQGVYANISLHAGLICIDAPGGLNMESQKRLFDLVLFNLEEHATLTNQVLQVTLSPDGSVELSRYGMPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X124</accession>
    <name>E8X124_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0822</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579215.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0822"/>
    <dbReference type="EnsemblBacteria" id="ADW67890">
        <property type="protein sequence ID" value="ADW67890"/>
        <property type="gene ID" value="AciX9_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0822"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045003_2_1_0"/>
    <dbReference type="OMA" id="AHWDSRP"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="PTHR12283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234060" evidence="3">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="91"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="33569" checksum="938E90083CF67C5F" modified="2011-04-05" version="1">MKKYAVLLMAMVFGAGSAWGAPAKAKVSGAATYALTKEYLAAAPKRFNGSPGHAAAEKFIEGHFNKENADHRMEVDTFTATTPAGMQTMHNIIVKYPGKKDGVIVLGSHYETNYPLKDINFVGANDGACTSALLMEFGEYFRAHPPEGYSVWLVFFDGEEAVKTWGPSDSLYGSRHLAAKWSQDGTLGHLKAFLNADMIGDKDLNIDHDDASTPALLDLFKVAAKNTGHEKSIYKSNTPIQDDTVPFAKRGVPVLDVIDYEYGPLDEKTGDYAYHHTAQDSIDKISAASLQISADLFLEMVHLIDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X137</accession>
    <name>E8X137_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name evidence="2" type="ordered locus">AciX9_0835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579228.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0835"/>
    <dbReference type="EnsemblBacteria" id="ADW67903">
        <property type="protein sequence ID" value="ADW67903"/>
        <property type="gene ID" value="AciX9_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0835"/>
    <dbReference type="eggNOG" id="COG0603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_0"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="OrthoDB" id="1681374at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="231" mass="25052" checksum="E83F430B9C678085" modified="2011-04-05" version="1">MSKAVLCLSGGMDSCVCAALAARDHELYAVHFSYGQRTEARELRSAEAIAKLVGAKDFLHLKIELFRRIGGSALTDRSIAVPDAVAEEAMHGRTGDEVPVTYVPFRNAHFLSAAVSWAEVLGAKVVTIGAVEQDSSGYPDCRPAYYDAFNELIRQGTKEGEIRVETPLIRMRKNEIVRLGVELGAPLHVSWSCYSGEDEACGVCESCALRLRAFREAGATDPVPYAAGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X140</accession>
    <name>E8X140_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0838</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579231.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0838"/>
    <dbReference type="EnsemblBacteria" id="ADW67906">
        <property type="protein sequence ID" value="ADW67906"/>
        <property type="gene ID" value="AciX9_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0838"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097928_1_0_0"/>
    <dbReference type="OMA" id="HHREYNA"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21661" checksum="4569106EA641A98B" modified="2011-04-05" version="1">MAERTGWQKVAKRIRVPMGFVTAAVFLWLARPSGKTLALSLLVVGPGVWLRAYAAGYVRKNAELTTSGPYAYTRNPLYLGSMLIAFGFAGAAGSWVLLLLLAALFAAIYIPTIQGEEQFLRTRFGNFDEYAAKVPRILPRLTAAPTNEERGEFSKALYLHHREYNALMGAGAIYAALALKLWAAYHFDMTRFLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F5</accession>
    <name>E8X1F5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3179</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581502.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3179"/>
    <dbReference type="EnsemblBacteria" id="ADW70190">
        <property type="protein sequence ID" value="ADW70190"/>
        <property type="gene ID" value="AciX9_3179"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3179"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_2_3_0"/>
    <dbReference type="OMA" id="WHRCVVF"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13971" checksum="0448F2D4A930C066" modified="2011-04-05" version="1">MYSNKVTLIGFLGNDAEVRTNNDRSLTTLSLATKSSYKKDGKYIEHTEWHRCVVFGKLGEFAATLKKGAHILVEGELRSRKYESTKTNSEQTTWEIRVDSILKLDRAAKAAVEDSEETLEEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G6</accession>
    <name>E8X1G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway VirB3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581513.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3190"/>
    <dbReference type="EnsemblBacteria" id="ADW70201">
        <property type="protein sequence ID" value="ADW70201"/>
        <property type="gene ID" value="AciX9_3190"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3190"/>
    <dbReference type="eggNOG" id="ENOG5031YUI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2478980_0_0_0"/>
    <dbReference type="OMA" id="GFRFLAM"/>
    <dbReference type="OrthoDB" id="1838445at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007792">
        <property type="entry name" value="T4SS_VirB3/TrbD/AvhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05101">
        <property type="entry name" value="VirB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9948" checksum="22960D352F2DB110" modified="2011-04-05" version="1">MARRGEPSPINQALNRPRAKLGLDLSAWMAIVFVCVTVFLVGFRLLAMLAFPTLAVCAWLIVRKHPKMFQLWGLSLNQKSYYDPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H1</accession>
    <name>E8X1H1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3195</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581518.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3195"/>
    <dbReference type="EnsemblBacteria" id="ADW70206">
        <property type="protein sequence ID" value="ADW70206"/>
        <property type="gene ID" value="AciX9_3195"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3195"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204309_0_0_0"/>
    <dbReference type="OMA" id="RVAISHE"/>
    <dbReference type="OrthoDB" id="1251632at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="24293" checksum="221DA7C913435C62" modified="2011-04-05" version="1">MTPFDCTQAKEMFSGYLDGAVNGREMQAMASHLETCTSCHAEFEAWRGMQGVLSAVGTAKAPEDLGVRLRVAISHENARRQGNWWDGISLRWSNAFRPALLQVTAGIACTVVLVGGIAGLIGVVAAPQAVQANDEPLGALSSPHYLYSAVLPQPVVTGQDAPIVIEAKINSDGRVYDYAILSGPQDLVTLAQIRDQLMVQVYEPARVFGEPVRGRVLITFAGVSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P6</accession>
    <name>E8X1P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS fold-4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0897</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579289.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0897"/>
    <dbReference type="EnsemblBacteria" id="ADW67965">
        <property type="protein sequence ID" value="ADW67965"/>
        <property type="gene ID" value="AciX9_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0897"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666933_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_4" evidence="1">
        <location>
            <begin position="137"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PAS_4" evidence="1">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="42942" checksum="DED5E495D3D6E12E" modified="2011-04-05" version="1">MLARMAFLHTPDERFIVLSEMASAASEPGRSCFSLTTFDHENTFLKLVATAEMVMDLTTEIIAAVLLSVSQPTFPHRWVEVGLNAAEIERLGLHAESVEVSQFVDPDPVVEIPAVPVKNPFSFQDGAEQFHEFLMQAPTPFVMTEGPEHRMTFINPPYVRLLGRLTKEAFLGKTVREALPEMEGQPFFGLMDEVYRTGVPYIGIEVPGRLQSDISQQEQDLFFDFIYHPLRDRAGRVSGVMIQATDVTDRVLSHQVMSSREDQLYTQWQELEAIYRSGLVGVMLLEANKELRILRINEIQAGLLGEPVDEVEGRPVRECCASVPALEALVERGLAGETVLNEVVRPMGGGGRDWLVSVTPLRSKTGVIEKLYCLSVEVPGPAGMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X216</accession>
    <name>E8X216_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3248</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581571.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3248"/>
    <dbReference type="EnsemblBacteria" id="ADW70259">
        <property type="protein sequence ID" value="ADW70259"/>
        <property type="gene ID" value="AciX9_3248"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3248"/>
    <dbReference type="eggNOG" id="ENOG502Z7XD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098538_1_0_0"/>
    <dbReference type="OMA" id="QHHRWAQ"/>
    <dbReference type="OrthoDB" id="1951499at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025570">
        <property type="entry name" value="DUF4337"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14235">
        <property type="entry name" value="DUF4337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20463" checksum="760EB6C3D5EA8249" modified="2011-04-05" version="1">MEPNEIQEFSEHLKEAGEHGGESLTTISLAISILAVLVAMVTVLGHRTHTEAVLQQARAADQWNEYQAKKIRSDNTQVAIDMLRLQANPNQAAVEKKIEDYTAHLEKWKEDLAEEQKKAKEFEADVVHAEAQASHFDLGEAMLQISVVLCSITLFTRRKLYFFLGVSIGAVGLLFAASAFLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X222</accession>
    <name>E8X222_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3254</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581577.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3254"/>
    <dbReference type="EnsemblBacteria" id="ADW70265">
        <property type="protein sequence ID" value="ADW70265"/>
        <property type="gene ID" value="AciX9_3254"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3254"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_0"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="463" mass="50503" checksum="EDD9ECC1C9FF7748" modified="2011-04-05" version="1">MAVAAAMGGHVRKRVVVVGAGFGGLTAAQGLAHLPVDVTIVDRRNHHTFQPLLYQVALAVLSPADIAQPIRSIVRDMKNIEVLMDEVVGFDTTERRVKLKTGSELEYDYLIVASGSTHSYFGNDKWAATAPGLKTVEDAIEIRRRVLLAFELAERQTLEVGSHPALNFVVIGGGPTGVELAGAISDIAKLYMARDFRHIDPSSAQVMILEGSPHILAAYPDDLQEKALEQLRELGVKVRTGARVTDVQPGYVMVEDERIDSVCTLWAAGVQASPLGKLLGVETDNKGLVMVDQFLNPKGMPEVFVCGDLAHVMQDGKQVPGVAQPAMQMGTYAAKRIGHAIEGAADKKGFRYFDKGDMATIGRSAAVANIKWPFKGHWSGFPAWMTWLSVHIFFLIGFRNRFSVFRQWAWTYVALSDGARLITGSQVLPGWEIQGDVHDTLTTKAFEPPQKPMDMGSPKTNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X251</accession>
    <name>E8X251_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3283</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581606.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3283"/>
    <dbReference type="EnsemblBacteria" id="ADW70294">
        <property type="protein sequence ID" value="ADW70294"/>
        <property type="gene ID" value="AciX9_3283"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3283"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_3_0"/>
    <dbReference type="OMA" id="FGMVLRI"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="476" mass="51119" checksum="CE0F20A698C5F2A1" modified="2011-04-05" version="1">MNLYAIVIGLIVITLLTVSLARFSKVKTKADYLVAGRSLPAFVLVFTLLSSWIGSGSLLAGAENAYKHGFAALWQAAGGWAGLILIYFIAPRARKFAQFTIPDLLEARYSQTARVLGVIAVLFTYTAITSYQLIGGGDIVHLIFPNISARHGQEIIAAFVIVFTAIAGMSSVAYMDVAIGILATVTLLVALPILTKSAGGWHQVAAVLPASHFQLMGDFSLLHCFELLIPTCLLMLGNQSMYQKFFSAKSEKDATRAVVGWFIGILILETVIVALAVVGSALFRTGEVHDNPREVLAYTALHGLPHIIGAIMVGAIFAKVISTANNFLFSPATNLINDVFVRYIRPDASNRTILLVSRLMVVFLGLWSLAQSLGTRSVLEKALYAYTIYSAALTPVILAAFFWRRATAAGAVSSIAAGTVVTVFWASDIVHTHLPPALAERDAIFPALIASLICLFAVSLLTSKPTEAQLAPFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A0</accession>
    <name>E8X2A0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0965</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0965"/>
    <dbReference type="EnsemblBacteria" id="ADW68032">
        <property type="protein sequence ID" value="ADW68032"/>
        <property type="gene ID" value="AciX9_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0965"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_0_0_0"/>
    <dbReference type="OMA" id="PLMYWMA"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="64"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="605" mass="67433" checksum="C149540FD9AB0FCB" modified="2011-04-05" version="1">MNELKIRTRSIATIVLFWLILQVGGLFTPGLLDDVDSVYLEIAREMLHRHDYVTPYIDGIRFFDKPPLMYWMAALSMRVLGETDWAGRIPLALAVLALLLAVYALGRRLYPESDRGAFYSSLALATAIGPYLYTRFYIPDILIALWMTLSVHLFLIALDRVKTSSALIPSLLFAATLALNLLTKGLIGIVFPILFVLLYLFLTRQFRALPKLHLIPSTLVFAAIALPWHVMAALRNPAIPMPSGLGLPQKAGWAWFYLYNEHFARFLGKRIPHDYGQTPVWLFWLYAAIWIMPWTTFLPGAIATIREQLGHRIEVTIRQREAALTVTLWALIVLIFFTLSSRQEYYQLPALPALALMAGGQLARNTRSNLTWHARFLVPLASLVAIICAFYALTAPHPAPQADLFTVLTQNVANYNLSLGHLFDLTGPAMGFFRLPLALTAIGMLILGPASYLLRRKSHSHAANLTLAAGMTVVLLAAHEGLVRFNPILGSKGLSEAILTAQQSPRPDDLILIDGELTAGSTLLFYTRQPVHLVEGRVNGPWFGSFWPDAPPIFETNQTLHTLWSTPRRLYILTYNPAPRTQELSAFGPVHTLASAGGKTILTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C8</accession>
    <name>E8X2C8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0993</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579384.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0993"/>
    <dbReference type="EnsemblBacteria" id="ADW68060">
        <property type="protein sequence ID" value="ADW68060"/>
        <property type="gene ID" value="AciX9_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0993"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159879_0_0_0"/>
    <dbReference type="OMA" id="WASKTED"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230183" evidence="2">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="25440" checksum="A34668160EE3ACB9" modified="2011-04-05" version="1">MKTLSAHSLLSAALLSFALSGCKKTPAPPAPAPVAAAPAPTPAPTPASTPAATPEAAAAPGATVSDPVTANGVTTQSTLGTGKTVEWALKQGEIKDDPSGQWPSAATASSAYNDAKDQQRFAPWQATGVPNVDQAGDNANAWDPKTPDGGIEWLDLLYPKPMPATGVRIRESANGGAVVKVDLIDEDNHLHPLWSGTDPTKALNYFMLTFPKTTYKVSHVKITLATNLIPGENEIDAVQLVSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G2</accession>
    <name>E8X2G2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2142</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580502.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2142"/>
    <dbReference type="EnsemblBacteria" id="ADW69186">
        <property type="protein sequence ID" value="ADW69186"/>
        <property type="gene ID" value="AciX9_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2142"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_0"/>
    <dbReference type="OMA" id="DYYWGMG"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="41039" checksum="9A3025497E7D7E29" modified="2011-04-05" version="1">MNEVVITSAVRTPVGKAPRGTLRTTRPDDLAAIAINGALARIPQLDHAEIEDVILGCAMPEAEQGMNVARVAALRAGLPITTSAMTVNRYCASGLQSIALAADRIRGGGADVIVAGGTESMSYVPFGGNKISLNPWLVENYPGSYISVGLTAERVATHYGITREAMDTFSYESHQKALNAIQQGYFDDEITPVEVVTTTPNAKGKAVTTTSTFARDEGPRADTSYEALARLKPVFHAKGTVTAGNSSQTSDGAAAAVVMSATRAQALGIAPLARFIAFAYAGCDPEEMGIGPIHAIPKALKLAGLSLEDIGVIELNEAFAAQSLAVIKVLGIDPARLNPNGGAIALGHPLGCTGAKLTATILREMQRRKVRYGMVTMCVGGGMGAAGIFENLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U0</accession>
    <name>E8X2U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581699.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3379"/>
    <dbReference type="EnsemblBacteria" id="ADW70387">
        <property type="protein sequence ID" value="ADW70387"/>
        <property type="gene ID" value="AciX9_3379"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3379"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="IMATVPM"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116670" checksum="BE25AB7F8558F749" modified="2011-04-05" version="1">MWIVKLALRRPYTFVVLSLLIFLLGIGSAITAPKDIFPAINIPVVTIVWTYSGLTPTEMEGRIVTVCERALTTTVNDIEHSESESYQGVSVIKVYFQPDVKIELAVAQVTSIVQTILRTLPPGSFPPFIIKYDASTVPILQLSLSGQGLSESDLYDLGLSFIRPRLSNVKGASIPLPYGGKVRQIMVDADPNLMYAKHLSAADVGTAIAQQNLILPAGTARIGDREYVVKLNSSPNEVSALNDLPIRAANGSVVFIKDVAQVEEGFAVQTNIVRENGKRGALLTVLKNGATSTLDIVDGVKKNLPKVLGGLPPNLKVTPLFDQSIFVRESISEVAREATIAAALTGLMILLFLGSWRSTLIVCTSIPLSIATSLVILTALGETINVMTLGGLALAVGILVDDATVEIENTHRNMSEKKPLVRAILDSAQQVAAPAFVSTLSICIVFIPVVLLTGAAKYLFTPLAMAVAFAMMASYFLSRTIVPTMMHFLLASEIRLYQDEGASEQEERESWVWRWHMKFDRQFEKMQHHYKNALEWCLENAGLTLILFFGFILLSLPLTFFIGEDFFPYVDSGQMRLHVNPPVGLRIEDSEQYFASIEKDIRALIPPDEIDLILDNIGLPTGGINLAFGNSATISNSDGEIQIALKPGKRKTTEYQRLLRDKLAEKYPGATFFFTPANITNQILDFGLPAPIDVAISGRGKGNYVLAQKIMKRIAAIPGAVDVHIHQQVSYPTLQVNVDRTKARQIGLTQQEIAQSTLISLTGTGQTAPNEWLNPLNGVNYQIVTQTPQYRLNSLQAMARLPITSTNGNVSQLLGNLATFKRDQSPIIIDHYNIQPVYDIYADVDRRDLGGVAGEINKIIKEESKGLPPGNAIDVRGEVTTMQTSFIRLGVGIVFAIGLVYLLMAVNFQSWLDPLIILMAIPGAFSGILWMLFVTQTTFNVPSLMGTIMTIGVATANSILMVVFANDERIAGKNQFDAALNAGHTRLRPVLMTALAMIIGMLPMALALGEGGEQNAPLGRAVIGGLLFATVGTLFIVPVIYSLLKKNAPVDYDKEIDEFDPDLHPEAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W9</accession>
    <name>E8X2W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579426.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1040"/>
    <dbReference type="EnsemblBacteria" id="ADW68103">
        <property type="protein sequence ID" value="ADW68103"/>
        <property type="gene ID" value="AciX9_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1040"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734927_0_0_0"/>
    <dbReference type="OMA" id="AWVGQQC"/>
    <dbReference type="OrthoDB" id="1860953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="43327" checksum="E8B989AE1D88899C" modified="2011-04-05" version="1">MPSSPTNPDAPTQPGYFADLYTFHWREISLQTSLIAIVAVAVSLVGGVLIGHPAAGLISGGGAMTVGFGLNQRISDSRLWPMIWATLAMAASTFIGMLAGHEGYALIFLSAAWAFGYGILTARAAGVAWVGQQAAVTLLVTSAFPADARHAFQRALLTLLGGTLQILFTSAFLRLLPELQADLLALPSYGFDEATHLRHIFRFGRILRRLRGFPRALPRMWAAGHVPYALRLALTVAAATEAYRWRGVQSGYWIPMTALLVQKPLFAETLNRALMRVLGTLAGAVLCTFFLLRVHPDPITLAWLAVFFCFCAFMANPVNYAFFSVFLTSYIVFLLSLNVLPGPEIAHRRAYATAAGGLIALIIHIDAFLLRRPKPSTSSPTKGVSKTTKGHSERSEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X313</accession>
    <name>E8X313_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1084</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579470.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1084"/>
    <dbReference type="EnsemblBacteria" id="ADW68147">
        <property type="protein sequence ID" value="ADW68147"/>
        <property type="gene ID" value="AciX9_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1084"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_1_0"/>
    <dbReference type="OMA" id="ERQGPMT"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16479" checksum="92E81A36462490C3" modified="2011-04-05" version="1">MSSKAPGKAFDRDIAEFTQSIGLLVRRSRAAAASHELSWTEARVLNRLAKDGPATTADLARVEGMRPQSMRPIIATLEQGGMIARQPHPTDGRQVNLVLTRKGEATQKSVREAKRTWITHAIAQLDKQDQQTLFAAGRIIERLLESNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8X330</accession>
    <name>E8X330_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2210</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580570.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2210"/>
    <dbReference type="EnsemblBacteria" id="ADW69254">
        <property type="protein sequence ID" value="ADW69254"/>
        <property type="gene ID" value="AciX9_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2210"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="DDQRNMR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="158"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="475" mass="53094" checksum="9513193457405AF7" modified="2011-04-05" version="1">MPQALTAPPTNATAADLIRILIIDDEPSIRESLETLLILEGFHVTLAIDGPNGLDTLSHQDFDLLLLDLALPGESGIDLLPRITAMHPHLPVIMITAFGTVNNVVDAIRAGAENFVQKPWDNEKLLADIRSAIARHRAEAEVIQLKRTLKQRYNFENIIGKSEPMLRLFDTVAQVAPSRSTVLLQGESGTGKELIAKAIHQNSPRRDKPFIPVNTGAIPSDLLESSLFGHVKGAFTSAISAKKGLFEVANGGTLFLDEIGTMSMDMQAKILRVLQDRRFMHLGGTTELQVDVRIVAATNVNLQQAVKDGRFREDLFYRLNVITLELPPLRQRREDVPLLAQHFLKFYAEENGTEAPSLSPEALRVLMDYEWPGNVRELENAMERGVVLSTTRTLTPDLLPSQLTGATYTASLLDQRPDASLFDVMEDIERRIIADRLERCHWNQTEAAEFFKIPLSTLNQKIKRLNVEIKKRPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X348</accession>
    <name>E8X348_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="9" type="ordered locus">AciX9_2230</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2230"/>
    <dbReference type="EnsemblBacteria" id="ADW69272">
        <property type="protein sequence ID" value="ADW69272"/>
        <property type="gene ID" value="AciX9_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2230"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_1_0_0"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="248"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="254"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="467" mass="51208" checksum="33EA7AB24E3BC13F" modified="2011-04-05" version="1">MEASAAQDAALLARELRTSQTQEELAVIVVVEFTGELRKRKQLTAAARSARTAAAVMAGEDEGELPEGSALDFEAGRAEFEELARSAGATIAATLVQRRQKPDPSSLVGQGKLDEIVGVVASTNASLVLFDHDLTPSQLRNIEARLPCHVIDRSQLILDIFARHAKTREGQLQVELAQLEYQLPRLAGRGRAMSQLGGGIGTRGPGETQLETDRRKINVRIDHIKTQLDGVRRIRQQQRQRREAVPVPVVALVGYTNAGKSTLFNALTEAGVLESARMFATLDPKLRQLQLPSRRKILLSDTVGFIRNLPHTLVTSFRATLEEVERAEILLHVQDASSPIVEEQKMQVEKVLAEIMAAKKPVIEVLNKIDLVPERGRLPHERGAVAVSSIQKTGLEELLLAIDKALVADPLVESSFRLPQSEGAVLASLEGGAVIEEKRFEGNLVYLKVKGPASLLGRYRRFRDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X349</accession>
    <name>E8X349_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2231</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580589.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2231"/>
    <dbReference type="EnsemblBacteria" id="ADW69273">
        <property type="protein sequence ID" value="ADW69273"/>
        <property type="gene ID" value="AciX9_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2231"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565923_0_0_0"/>
    <dbReference type="OrthoDB" id="225322at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="482" mass="52567" checksum="9BE6FD59B4917C54" modified="2011-04-05" version="1">MPNGGSNKELLLILARGAEAWNEWRAEHPDEPVDLTDASFRKAELRGVDLSHTYLNRINLSETRLRGANFNGASLNWADLREADLRGAKLRGADLRGADTKGANFGECDLSGANLTGVDLTEVNLSGAVLEGCRLERANLSDTNLRDSRLSGANLFRAKLWRARLNGCDLSGVNLRESDLTEADLRYTKLQDADLRSARLKAAALDHANVTGIQLWETQRSGWSIHGIVCEAAFWDERGEERVEYAPEEFEKLYSVGMRVELVYHGGITPFEVNTLPALLHHLATLHPESGIRLKSIEETGGGVRVSIHVDEADAKTLDAIRAEAKESQAAQVALRDNVIARLEIEKRLLLDDVLPKMLAASGQHVQITGSATNVVIAGGQASVKAEQTIGESKEIVSLLREMLLRRDDLSEGQATELEGAAESVGAELQKEKPKAGVVAAGLGVMKEIAVKVVESATEKALLEHWQPMLHTVTHLLGQVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X365</accession>
    <name>E8X365_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2251</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580605.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2251"/>
    <dbReference type="EnsemblBacteria" id="ADW69289">
        <property type="protein sequence ID" value="ADW69289"/>
        <property type="gene ID" value="AciX9_2251"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2251"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_3_0_0"/>
    <dbReference type="OMA" id="IGKIPHP"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="3">
        <location>
            <begin position="89"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="31786" checksum="43884AD0B25F2BA1" modified="2011-04-05" version="1">MLNRGYAYTTIIGSKQHGWTLLSHLAGLYPHSSAEAWQENLDNGEVTLDGITAAGSELLSSGQILVWKRPAWIEPDAPQHFEVLFDDLHLLAVNKPSGLPTLPGGGFLENTLLRLVHRHSPSANPVHRLGRATTGIVMFAKTAQAAAGLTADWNTPRVQKIYRALAQGVARQEAYEILTPIGLVPHPRLGSVWAASAGGKASKSSAKVISRTAATTTFEVRLGSGRPHQIRIHLASIGHPLVGDPLYGSTGLPLDDLPGLPGDGGYLLHAQFLKFHHPVTGEQIELEAALPSGFLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E3</accession>
    <name>E8X3E3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3439</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70444">
        <property type="protein sequence ID" value="ADW70444"/>
        <property type="gene ID" value="AciX9_3439"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3439"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308670_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="23784" checksum="B03E455E9765F5BF" modified="2011-04-05" version="1">MIAAQSLAAVMQNRLQTSSEEVRRLLQNCEEIIVFGSYAAGLSTSASDLDIFCIGNERKHLKSKAIDLLVLRKEDVRLPLWLGSELASHIKEFGVPLTGEHDWLKDVTQSLVAITKKENRINAYSRSLNKHWMALNGSSKKKYSLKVRRELQRLSILVAKHPVPPTKILDQLWSSPNTRVSEELRVFSIAKRLALSDTSFLEPELYDSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K9</accession>
    <name>E8X3K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PASTA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1137</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579523.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1137"/>
    <dbReference type="EnsemblBacteria" id="ADW68200">
        <property type="protein sequence ID" value="ADW68200"/>
        <property type="gene ID" value="AciX9_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1137"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933617_0_0_0"/>
    <dbReference type="OMA" id="FVWQDRY"/>
    <dbReference type="OrthoDB" id="1543023at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="277" mass="28535" checksum="78DD6A0018BD2311" modified="2011-04-05" version="1">MKRILYIILGGMLMFVVTLFAAFSSMRLAIHGREVDVPSLSGLSDQDAAEAARKLGLNLSVENRFYSAAIPPNHVLSQSPAPGSLVRRGWQVRVTESLGGQQVSIPDVTGQTERPAALVLKRLQLDLGGTSHLPAPGPEGTVLAQSPPANSGGVFGPHVSILVAAPETDAPAQAYVMPAIVGLTISAANTRLATAGLHIASSVDPSTIPPPEPLDTTADPAIPPTVIAPPPVSTSAVIVSQYPAPGHRITHSDNIKVTVAHPADTSADATTPAPSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M8</accession>
    <name>E8X3M8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="10" type="ordered locus">AciX9_1156</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579542.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1156"/>
    <dbReference type="EnsemblBacteria" id="ADW68219">
        <property type="protein sequence ID" value="ADW68219"/>
        <property type="gene ID" value="AciX9_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1156"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_2_1_0"/>
    <dbReference type="OMA" id="AWGFVEV"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="15288" checksum="82B6A261D0F906A5" modified="2011-04-05" version="1">MANTGQDGKLAVRLVTPDRVLLDGFADAVELPSASGYLEALYGAAPLLAELGAGEVRLHGGDSDGKVFFVAWGFVEVLPERVTILAETALKPEEIDRAAAEAELKRGETMWSEAGDDGAKYDEANELTRKAEEELASADHRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P5</accession>
    <name>E8X3P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2285</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580639.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2285"/>
    <dbReference type="EnsemblBacteria" id="ADW69323">
        <property type="protein sequence ID" value="ADW69323"/>
        <property type="gene ID" value="AciX9_2285"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2285"/>
    <dbReference type="HOGENOM" id="CLU_2601150_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="79" mass="8701" checksum="E0F8F14F064CA468" modified="2011-04-05" version="1">MTIEIHQPELEALIQQRMASGHFQDVEDVLIQALKLAPSVNDSAATQQTLEEMFAKARGLGDDLDITRDPSPGRIIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q3</accession>
    <name>E8X3Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2293</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2293"/>
    <dbReference type="EnsemblBacteria" id="ADW69331">
        <property type="protein sequence ID" value="ADW69331"/>
        <property type="gene ID" value="AciX9_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2293"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_0"/>
    <dbReference type="OMA" id="FQMLAIS"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16333" checksum="1740CD8FE4950FB3" modified="2011-04-05" version="1">MAGLTACDRGSHPGNIGKPAAQFVMTDGVETVDLAKLRGKIVVLNLWATWCAPCVQELPSLLALKQKMPGIAVVAVSTDQDDEVYRAFLVKHHVDIPTVRDSDAKINALYGTVQIPETYIIDRNGVLRRKFIGAQDWTGPEITDYLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3S3</accession>
    <name>E8X3S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Urea carboxylase</fullName>
            <ecNumber evidence="11">6.3.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2314</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.6" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580667.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2314"/>
    <dbReference type="EnsemblBacteria" id="ADW69351">
        <property type="protein sequence ID" value="ADW69351"/>
        <property type="gene ID" value="AciX9_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2314"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002162_3_1_0"/>
    <dbReference type="OMA" id="TLQMWNR"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004847">
        <property type="term" value="F:urea carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014084">
        <property type="entry name" value="Urea_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02712">
        <property type="entry name" value="urea_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1227" mass="132698" checksum="3AA2245F0265FDC3" modified="2011-04-05" version="1">MFTKVLIANRGAIATRIIRTLRRMGVASVAVYSEADATSLHVLQADEAVLLGPAPAAQSYLSFDAIFAAAAQTGAQAIHPGYGFLSENIAFARECTARGLVFIGPTPANIDAFALKHTARATAKQCGVPLLPGTGLLADKQDALTQAETLRYPVMLKSSGGGGGIGMKVCHSAPELEEAYDSVLRLSKANFGDSGVYLEKYVARARHIEVQIFGDGQGNVIALGERDCSAQRRHQKVLEETPAPGLSAATRKHLYDSAVLLGKAVDYANAGTVEFIYDEDTTDFYFLEVNTRLQVEHGVTEQVTGIDLVEWMVQQAAGELPDLTKVNVTLTGASIEARVYAEDPARNFQPTPGKLTLVTFPGPEISRTETWIESGSTITPFYDPMIAKIIVTGKDRTEALTKLQTALEATKIDGTETNLHYLLEVARSPEFQSGTVTTAFLGTFTFARNAIEILEGGTQSTIQDYPGRTGFWNVGVPPSGPMDHLNFRIANRIVGNSDNAAAIEFATMGARMRFDCETTIALTGADMNAKLNGKPVEPFTPIPIHTGDTLSLGAASNVGVRAYLAIRGGLSTQPYLGSRSTFMLGGFGGAAGRALRGGDVLHLGQPDVTLTAPIALPIAQAPPLAKAWEVGVLFGPHTAPDFFTEEDIEMLFATHWKVHYQSDRTGVRLTGPKPKWARPDGGEAGLHPSNIHDNAYAIGTIDFTGDMPIMLGPDGPSLGGFVCPATIVQAELWKLGQFKAGDTVHFNRLTLAQAEQMERAQDTFLQSFTTPLPSLTGVILPQSEATGENLSSSLEAEQSSPVLSFRSEAEEPAVILSLTTRPTPMVFRADGDKYLLVEYGPLQLDLTLRFRVHVLEQNLRAANLAGIIDITPGIRSLHIHYDSRILVRAKLIDTLAALDEAMPPLTDITVPSRIVHLPLSWDDPQAKLAQQKYMQAVRPDAPWCPSNIEFIRRINGLDSIDDVYRIVHEASYLVLGLGDVYLGAPVATPVDPRHRLVTTKYNPARTWTPENAVGIGGAYMCVYGMEGPGGYQLVGRTIQVWNPWKTTEAFTPGKPWSLRFFDQIRFYPVSPEELMDARARFPHGQYQLRVEETTFKLSDYLAFLDSIAPEAAAFKAHQKAAFNAERERWIAAGQMTIVEPAEAPADTPDVVVPEGCEPVSSSVTASVFQIPVKAGDKVEEGQKLVVLDAMKMEIAITAHTAGTVEAVHCTLGSLVTSGQILISLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A6</accession>
    <name>E8X4A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579556.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1170"/>
    <dbReference type="EnsemblBacteria" id="ADW68233">
        <property type="protein sequence ID" value="ADW68233"/>
        <property type="gene ID" value="AciX9_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1170"/>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_4_0_0"/>
    <dbReference type="OMA" id="NRVAWCR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="332" mass="35718" checksum="D74100C6B5E674FC" modified="2011-04-05" version="1">MKVGVVALMMGFTLGGWGQGLKTITVGPAGSRADFATVQEAVTAAPETGAVIRIRPGIYREVVHVDKANIQMRGETKDASTVVIVDDMGDPKTCGTFCSPTMFVTGDGFVASNLTISNDLSKTGKPRTQGVALSITGDRAVLRNVRLLGAQDTLYAASRKCAAGAECKASRQYYDHCYIEGEVDFIFGNAKAVFHDCEIHSVVHEAGGYLTAQSRNSVAEDSGYVFDHCRVTAEPGVSKVYLGRPWRDYATVTFLNTELRAHIAPAGWSEWHQGETDRLKTASYAEYRSTGPGANVAEREPLSKQLTADEAKGYEVKKYLAGSDGWDAAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B3</accession>
    <name>E8X4B3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Semialdehyde dehydrogenase NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579563.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1177"/>
    <dbReference type="EnsemblBacteria" id="ADW68240">
        <property type="protein sequence ID" value="ADW68240"/>
        <property type="gene ID" value="AciX9_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1177"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_0"/>
    <dbReference type="OMA" id="MDFVFFA"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdhyde_dhC" evidence="2">
        <location>
            <begin position="157"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="347" mass="37057" checksum="278AD2E5631587DD" modified="2011-04-05" version="1">MADGLYRIGIVGATSLVGKELSDELQESLLAASDFVLLDDEEEATGVVASVGDEAAFVQRIDSGSFDRMDFVFFAGNAASTLKHWPAAKKAGVSSIDLTYALEQETGVPVRAPFVADAMKKRAEGQPTLETASVVSAHPAAVMLAAVAARLQAGLAVESFAAVVMEPASQYGREAMDELHQQTVNLLSFKDLPKEQYDAQVAFNLLPSLGEDAKVKLAESENRIRRHYGAIGGLPTLEVQLIQAPVFHGYVASVLVELKAEATAAEVETALMGESIDVVTDESDPPSNLSAAGQEDIMVRVRGAAGVGVRSRRFWLWMAVDNLKLTALNAISCANELRRLRPSGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B8</accession>
    <name>E8X4B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1182</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68245">
        <property type="protein sequence ID" value="ADW68245"/>
        <property type="gene ID" value="AciX9_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1182"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_0_0"/>
    <dbReference type="OMA" id="TLYVYFD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="24318" checksum="90C9085FB6F32D60" modified="2011-04-05" version="1">MSETISGVKRRGSGRPPARELEAHKEAILDAATATFLEHGYSKASTAEIARRAGASKQTIYSLYPSKAELFAALMQRRSARLIDPLASQVLRDDAPVEEVLRRFAFQVVRLLLTEVSQRLHRIIISEAKSFPELVGAFWANGPGWGRETLKVYLDAQVAGGVLEVGNTRYAANQFIGSLADVIVMHSMLMLPTPLEGEKAIGDWVEMGVSAFLRAYRKMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K3</accession>
    <name>E8X4K3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2376</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580729.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2376"/>
    <dbReference type="EnsemblBacteria" id="ADW69413">
        <property type="protein sequence ID" value="ADW69413"/>
        <property type="gene ID" value="AciX9_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2376"/>
    <dbReference type="eggNOG" id="COG1832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_0_0"/>
    <dbReference type="OMA" id="MVMDRCP"/>
    <dbReference type="OrthoDB" id="1910664at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14312" checksum="79AD335B31767D10" modified="2011-04-05" version="1">MNEPEAIQAMLAAKTIAVIGLSEDASKPSHYVSAFMQAQGAKLLPINPAIDSVLGEKAYPSLTALPEKPDVVNVFRLPRFIPEIVDEMIALGLNKLWVQQGIVNLEAAAKAEAAGIQVVMDRCIMVEKRFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N5</accession>
    <name>E8X4N5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">AciX9_2408</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580761.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2408"/>
    <dbReference type="EnsemblBacteria" id="ADW69445">
        <property type="protein sequence ID" value="ADW69445"/>
        <property type="gene ID" value="AciX9_2408"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2408"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_0"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002128">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chlpt_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01010">
        <property type="entry name" value="Proton_antipo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="16">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="15">
        <location>
            <begin position="137"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_C" evidence="17">
        <location>
            <begin position="473"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADW69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="664" mass="72214" checksum="F0D520982B3037E9" modified="2011-04-05" version="1">MNPNTLWLIPLSPLLGFLINGTVGRKLPRPFVTAIALIATIIPAVKVFQLWLFMKFAADGPLTMSVVSRPWIDITNFHVDFALSVDHLTLIMLGVVTGVGFLIHLYAAGYMAHEDGYWRFFAYLNLFMFFMSVLVLADSFLLLFVGWEGVGLASYLLIGFYFTKTSAANAGKKAFILNRVGDFGFLLAMFLLIAHFGTLSFSEVFASITANPGLHGGFLTAIALLLLVGAAGKSAQIPLYVWLPDAMEGPTPVSALIHAATMVTAGVYMVARCHTLFDRSPFALAVVACIGAATAIFAACIALVQHDIKRVLAYSTVSQLGYMFLACGVGAYTAGIFHVLTHAFFKALLFLAAGSVIHALSGEQDMRVMGGLRKRIPVTFWTMTMGVFAIAGIPPLAGFFSKDEILFQAYSWTAYPALGKLLWLVGLITAGMTSFYMFRLWFKTFFGAERFDEHHLGDTSHNAEHDDSEATHSHGVHESSWIMLAPLVILAILSVVGGWVGVPAALGGHNEIEHFLEPVFASGIAEPLAVASHGSEIGLAAVSVITALLGFMLAYLWYYKKPGTAAALAQRFPHPYNLVANKFFVDEIYNAIFVTGLLGFTRIFLKGFDSIVVDGFGKFAGWVAFDFGEVTRRIQSGNIRSYAGWLALGAAAVMVVMIFGRFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N6</accession>
    <name>E8X4N6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-translocating NADH-quinone oxidoreductase, chain M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2409</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580762.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2409"/>
    <dbReference type="EnsemblBacteria" id="ADW69446">
        <property type="protein sequence ID" value="ADW69446"/>
        <property type="gene ID" value="AciX9_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2409"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_0"/>
    <dbReference type="OMA" id="ITRWGNQ"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000260">
        <property type="entry name" value="NADH4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01059">
        <property type="entry name" value="Oxidored_q5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q5_N" evidence="6">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="135"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="544" mass="58745" checksum="041D6708305B59E9" modified="2011-04-05" version="1">MNIDTSILTLIIAVPLAGAAVLALLPDRGNIQKFGALIVTLFTLLCTLHLPAHFNGAAPAGSFQFVIDHDWITAPSIRYHLGVDAMSMWLVVLTAFLAPLGVLASWKIPSINERAKTFYVLFLLQQVAMLGLFLALDLFLYYAFFELSLVPMTILIATFGRTKNRRPAAIKYFVYNFIPSAILLVGILWLYVKTGTFQFPALAGLAAAHNISPNGSALGLASLAFLIAFCVKVPVFPLHGWLKDAIVEAPTAAVMVLAGKTGLYSILRFSFGIFPEQSHHIAPLMLALGAIGIVYGALIATTRNDLKELAAYSTLSHLSFITLGIFGFTIAGLDGGIYQILNHGISGSALFLLLGFLYERYGTYDMRDLGGLAQKLPWMVTLYVITTLSVIGLPGLNSFVGEFLVLSGSMQAAFAHHVFWTVLATTGVILSAAYMLIMIQRVFYGHLGVTSSGQPSIDLNAREHTALWPLVAVMVLMGVSSPYWLHTIDTNGVAMSLQRTAAPAEAPATRIESESYPKPVFVDPALGAAALHQQPEPALKGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q4</accession>
    <name>E8X4Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3538</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581854.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3538"/>
    <dbReference type="EnsemblBacteria" id="ADW70543">
        <property type="protein sequence ID" value="ADW70543"/>
        <property type="gene ID" value="AciX9_3538"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3538"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072679_0_0_0"/>
    <dbReference type="OMA" id="SFEILTH"/>
    <dbReference type="OrthoDB" id="1027546at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230688" evidence="1">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="259" mass="28054" checksum="9C1C75AD9BF336A2" modified="2011-04-05" version="1">MSNVPSTRSFILAAAAVLAAAAVFAVQFAQAQYRTPKQVPGVRPCPKLEGSRRIEEFNRPAVEILVKMNVDVDGAPNAYGPPGKKALDIDAHARAPKESEHPGAIVGYMTEYEGGPPTKQGPHDPYPGYFVSQTDFADLSNKRMEDPRRYVDAARINYLVQGRVAKQTGVALGDFATVYSCRTGRTAFAIVGDSGNESGAEGSLALVQNLGYPIKDGVEDSVDDREIVIHYFPKSNPTKQFFHTQQELDAAALKLGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T7</accession>
    <name>E8X4T7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3572</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581887.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3572"/>
    <dbReference type="EnsemblBacteria" id="ADW70576">
        <property type="protein sequence ID" value="ADW70576"/>
        <property type="gene ID" value="AciX9_3572"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3572"/>
    <dbReference type="eggNOG" id="COG4731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108869_1_1_0"/>
    <dbReference type="OMA" id="ARCHDGK"/>
    <dbReference type="OrthoDB" id="1848240at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2147" evidence="1">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="16610" checksum="3C99CE8A0B9344ED" modified="2011-04-05" version="1">MGKVGLWAAGLCVVGVLGLSLGAATLGAQAPDKTGVLGDWQEPGGGVLEVYKCGSQEICVKLRMLAADTPAKVDGHNPDPALRTQSLCDLRVGYEFKLTDPDHADGGKLYDPKSGKTYSGTMSTEGDKLRLRGYVGIKLFGRTEVWKRAGAFHGCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X0</accession>
    <name>E8X4X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3606</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581920.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3606"/>
    <dbReference type="EnsemblBacteria" id="ADW70609">
        <property type="protein sequence ID" value="ADW70609"/>
        <property type="gene ID" value="AciX9_3606"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3606"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749602_0_0_0"/>
    <dbReference type="OMA" id="LRIEFRI"/>
    <dbReference type="OrthoDB" id="1009237at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="39707" checksum="8FD99CFE88CD013C" modified="2011-04-05" version="1">MPSLETPPNPAPPTPPPAQQPPVRLQTRRFGELEEHELIHLLDSLDDERSRSRFRESIYVSLLFYVALAWFVLYGPRVLWHSPQIVPVETKRDNKELTYLETPKDLLKHIPKPTTVISDKSAVAQTAHPTPEAKRGTPPPQAAAPRPAPRPLPPTPQPQQQAPPQQQAQVQPQPQQPKPLPPQPAHPQPSQAAIPDAPRPSQSTRPNFGTPMTPGQSIAQAAHDAASGGGQGAGGDNGTGARPGHPGTNTGAEILSDTLGVDFGPYIQRLLRMVRAAWIPLIPEETRPPISKEGSTLIRFTILPDGRLKIGGMHLDASTHDRAIDEAAWGGIVGVGQYPPLPANFKGPELTLRIQFNIVQNHRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X504</accession>
    <name>E8X504_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578524.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0118"/>
    <dbReference type="EnsemblBacteria" id="ADW67196">
        <property type="protein sequence ID" value="ADW67196"/>
        <property type="gene ID" value="AciX9_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0118"/>
    <dbReference type="eggNOG" id="ENOG5032T9P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120565_1_0_0"/>
    <dbReference type="OrthoDB" id="1814769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="15315" checksum="8F874B83A36BB4AA" modified="2011-04-05" version="1">MLEVARWLITFVAFVTALGGLMADYFIPSSGAQHIKNPRWPPHAKFHNAQSILMGLSMGVLAIAILFRQSPVSRSGLLLAALLASIYWLCIFAAPIFPGTAFVDPEFASATPKLMGIPGQLSIGFVLVAILLVAVVLAIFPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X540</accession>
    <name>E8X540_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0158"/>
    <dbReference type="EnsemblBacteria" id="ADW67232">
        <property type="protein sequence ID" value="ADW67232"/>
        <property type="gene ID" value="AciX9_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0158"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_5_0_0"/>
    <dbReference type="OMA" id="GRDCWCP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="461" mass="50565" checksum="2452CB237F345C03" modified="2011-04-05" version="1">MPGGEGLWREDGCGAVCFLVMSERADALRRQILELTAEYHAEAFPKREFVAGASAVQVSGKVIGADDMGAVVEAALDGWFTTGRWAKEFERKLARFFGVRSASLVNSGSSANLVALSALTSPKLGDRQLRPGDEVITVAAGFPTTVNPIIQNRLVPVFVDVTLPTFEIDCSLLEEAYSPKVKAVMIAHTLGNVFNLDAITAFCKEHNLWLIEDCCDALGSTYKGRKVGTFGDIATVSFYPAHHITMGEGGAVLTDKPALQVLIDSFRDWGRDCWCEPGVDNTCGKRFEWELGTLPCGYDHKYTYSHIGYNLKATDMQAALGVSQIAKLPGFIERRKENFAYLWKALESLQDVLVLPVAGDGADPSWFGFPIAVKPGAPFTRDQLTRHFEAKKIGTRLMFAGNLLRQPAYQGIECRVVGDMKNTDYVMDRVFWLGVFPGLTREMLDYVAGVAGEFCSGLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X598</accession>
    <name>E8X598_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein UCP033563</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579685.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1300"/>
    <dbReference type="EnsemblBacteria" id="ADW68362">
        <property type="protein sequence ID" value="ADW68362"/>
        <property type="gene ID" value="AciX9_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1300"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031277_2_0_0"/>
    <dbReference type="OMA" id="IYIADGH"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="464" mass="52532" checksum="7A174742CB4827F1" modified="2011-04-05" version="1">MAKIYPFRALRYDTTKVQMEDVVTQPYDKITPAMQQAYYDRSKYNLIRVILGKKEPDDTDPYAAGSIDTPQQSVYTRAAESLKSWRKKGILKEEGEPALYGYSQTYTVPNTDEVRERRGFIGLGHLYDYADQVVYRHEQTFPKHKSDRLALFKSTRAYCEQIYMLYSDPAFTAEKLIFDRGAAADLQITDEYNVVHRVWKLTDPHLINLIVGAMADKKLIIADGHHRYETSVTYMHERAEQLGLNQPKSDEDDRESEESPSARVDEGHSFLPKPTFPEAAMMMTFVNMEAPGITILPTHRVLFNLGDFITADFLAKAAAYFEITPLMEPNLEELSATDKTAFVVVTRDGIHLLTAKPEAIAEALQGISARQAQLDVVQLHTLVLERLIGLSHESIAAVENIRYLRDAKEAVEQVHKGEADVAFLIKPVTLTQLRDISLSNDVMPQKSTDFYPKLLSGLAIYALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C4</accession>
    <name>E8X5C4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2436</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580787.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2436"/>
    <dbReference type="EnsemblBacteria" id="ADW69471">
        <property type="protein sequence ID" value="ADW69471"/>
        <property type="gene ID" value="AciX9_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2436"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="FAGEVNY"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="459"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1157" mass="124572" checksum="CC0F9285BB456F17" modified="2011-04-05" version="1">MNHHRGLFHNLKAAAEGTPTQQEASSPHNTKNMYRNRFPRSVISVGIVCSMICGTPSLLLAQSTFGSIKGTVQDSTGATIPGAHLTLHSVDENTDRPLDVDPSGNFTFENVKAGKYTLTAHRDGFADTVVSGISVEARQDLRLAATLNVAAQSTTVEVSAAADQINTENGTISDSKTNIQMTQLPLNNRATTTSPLGALALSPNVQTDSSGNIALGGASSSMVNFSVDGISTANVRQNGALQDAYPSQEGIAAVKVTAFNNSAEFSQIGDVTFTTKNGTNDYHGSVFEYLQNQALDANPYGFTGKAPKKFNTFGFSLSGPISIPRLYNGHNKTFFFADYEGNRRSTAVLQQFVVPTVAERSGDLSDIGGPVIPASSISPTAKALLAHYPLPNIAGVTGASTINYTNFQATPARTDGADIRVDQTINSKQSVYARFSRKNITSSFANPFLPDDEDSIHNRSFLVSHTYTITPKLLNEFRIGFTNVSTNVDFPIQGSTALTQLGLTGVDISQHPLTHAFPTFNFTAGTNFTPIGRDKAGITQSKTTQISDNVTLTIGKHTLKGGIDIRHVRYFDLESFAPQFASDDFGNFVFQPTFTGNAFGDFLEGAPTTLNFAVSSPDVGGTATQYSLFAQDEFQLNSHLTISYGLRWQVLPGFKEDGGNLANFDQRSNSIVVPDALANYLTSQNITSSNLAFQQSFNACNLNNTSIPCTKYITASQAGLPQSLRNTYKGDFQPRVSIAYRPFNDTKTVVRAGFGIYTMTNLGPLSFNNSGNPTSNLHTYSNSNTAGANTPQIRFPNTAPSSMSGPVFGGGGLDQGVDPNFRDPQSNQWNLTVERELTAATALRASYVGMHSYRLNLTEDLNQIPASTIPYNSGTTAGTFVDSRAPYQNWTTLLSTFNAGEANYHAFELEATHRLEHGLYFDANYTFAKNVADNQGDAPSAFAGEVNYGLPIADRFHIKQDLGNTEGTRRHRVLLTGVYQLPFGKGRAYMNASRFTDTIFGNWDLTTITLLETGPWLTPSISSSADQSNTNVVNRSAVLRPDVVSNHYYTGQSRAQYFNLAAFSPTPAGAGRFGNAGVGILQGPGTATVSLGIAKRFAITERVHARFETTFTNILNHTNFAPPVTAIDNLLFGQLTGPQTAESAGNRTGQAALRIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G9</accession>
    <name>E8X5G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron sulfur-containing domain, CDGSH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2483</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2483"/>
    <dbReference type="EnsemblBacteria" id="ADW69516">
        <property type="protein sequence ID" value="ADW69516"/>
        <property type="gene ID" value="AciX9_2483"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2483"/>
    <dbReference type="eggNOG" id="COG3369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173940_2_0_0"/>
    <dbReference type="OMA" id="GHFEHEA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="9627" checksum="9EE09583C95CA3F6" modified="2011-04-05" version="1">MADELLSGSEGTSGSLPTVKITVRPNGPFRVEGPFQLVDVEGKEWDIAGRAIVSLCRCGLSTKRPFCDGTHGKEGWKCDASPVPVEPVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H7</accession>
    <name>E8X5H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig domain protein group 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2492</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580840.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2492"/>
    <dbReference type="EnsemblBacteria" id="ADW69524">
        <property type="protein sequence ID" value="ADW69524"/>
        <property type="gene ID" value="AciX9_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2492"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_225035_0_0_0"/>
    <dbReference type="OrthoDB" id="1139at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="3375" mass="343077" checksum="033A9BE092C35C4A" modified="2011-04-05" version="1">MTHIRPVTRTPHNPAGATATSSTRYRRHLTRLLTVVTTASLLFHHTATEVYAQQYADQNCTASILNRSVPVAADGTFLIPNVPVNPGTYRARVICPQTDGSLLGSTSDYLTLIPNGSTSLPLLPIGPLSAQPSALKVQALSGALSAVGATVQLETQAIDPSTYSYDYTKVTKGTTYTSSNAAVATVDANGIVTAKGPGAVIITARNDGLSSTILLTSFGLLDSDGDGLPDSYEIANGLNPFDPTDANLDSDGDGLTNLQEYQLGTNPRIADTDGDGLNDGDEVRLGTNPLVADTDGDGLNDGDEVRLGTNPLVYDTDGDGIPDGIEVRLGLNPLVPDVTTTLTGHVSNPDGTPAVGASILVLTYFTAVTDTTGAFTLTSVPTSLGNFVVSARAIVGTTVYNGASKATPPVGSGTTDIGTIQLGQSSGQVSGTITNPDGTIVRAAQVTLTDGMDVRTTVTDGTGLYLVTGLQSGTVMASAFDPNTSLRGQAVSALNAATPLTLNVKLSAFGTVSGTVRTPSGTPVGAGATVIITGALNATTTTDLLGHYAFTFVPLGGYTVDATDTAGNHGRATGTITATSQTINADVQYLGRGTVTGTVADASGTAIAGAAVQLYDSGIFNSYANTTTNSLGQYTFANVFIGPLTLSASSTSSSTGGSASSILSTDAQTVTVNIALGATGTLTGTVFRADGKTVVPGALVSVTGSAATALTNAAGVYTLGNIPLGGITAQASDASTSDRGHATGSVTSGQTSTLNITLIGLGTVNVTVQDAGGTAKAGALVQVQNVSAQFPATQNGVSASDGTVAFTQQLAGSQTVTASDPTTGLAGTANATLAAAGTVAVVVKLQASGTVQGTVYKHDAVTPLPGATVVLDGQRSVTADVNGFYTLTVVPSGTHQVYVADSINNTLAINNGVVITTQGQVVTSNFVITGRGTVTGLVTNQDGSIAAGIPVQLTSNAPGDSNPYGTQTDVTGTYTLLNIPIGTYRVIAQQHTATTNTYGQATGSVTTDASTTTTNIQLSTSLVPSTVSLTDANGASYPIRENGGIFDGSYSVFQGDAAANEGGSLLSVVLNGTETKFTGAALSPSSLAGRQISIEQDNLAGLNITRRVFVPGDGYFARYVELLTNPSAADITVDLKLLSNYRQLRTINLGTTETANFSVPVILQTSSGDNILNISDPTNPDSWVTFGGPVDQDPFVPSLFADNPIPPIADVFDGPKAPLKPTSVLYAQGSAGNYSTLTQTYSALKIPAGGTVGVMHFISQENAFAAAAASAARLVQLPPESLYGLATSDLAAIQNFVIPAGGTSTIASLPPVTNQAGGVVYTSDSTTPFASSQVRFHSNNPIFARTYITTADGAGNYSFQGAFQSLAIPQDDFTVTAYEPSNGTFLDQTCAQIGVAIGNGCGIPSPVTAGTFGTGQTPGAGTATQNIVFSNTGIITGTISRGPVVLNVAGTVSLTAGPMLPLTNIPIAADGTYKIYGVVPGTYIITAYVTNTLLTGISSVTVTAGTATTTNITIGESGNITGTVTRDDGSLAIQDVVNLRSSTGVLSTSVNTAGQYAFTDIPIGTYTLDVYDSQSNSAVTATAAVSSNATTTQNLVLSSKGSVTGTVNVNDGSSVANLAITLTSTTTSGIQTLTGSTNATGVFTINGVKPGAISVHAVTSSGLQGTGNGNLPLAGQTVTINVSLTATGSVTGTVFQGDGKTPAPNVTVTISPAPFTGTATTTTDSNGVYNFPNQPFGNFTVYATLASTGDQGQTNSQIQANGQLRTVNITLNGFGNLTVKVVDSGNNKIAKAALTVYNNTIGKQYTATADATGTAVFTNIFAGSLTITAKDPVSGLNASTSTTLAYNASQTVTLTVQATGVIQGIVYNVDGVTPVAGATIQVGVPYGPTQLTAADGSYKFASAQLASYNFQVHDANGVIRANAPYQTLQTAGQVITQNLTFVAIGSVHGTVLNADGTRGENLTLTINSSNANIGGQQSVVTGGDGTYTVPAVPIGNFTVTVNNLSTSLAGFATSAITKDGDSEQVDIQIISSTVTLPATLTDADSFTYTVGTAGTYGPTGNIGTNLSPFYNANNLTLTVAGAGAAFGNGGSPTTAIQSLSGQQIEINQPSLLGLNVTRKIYVPTDGYFARRLEVFQNPTSSPITVTVQENGYDRYTPNAIRIVNTSNNNTTVDNTILWAVDDDDAGGLPYPRTQPALANIFAGTGAPTTLSGVSDNVASNSYPSNGVYFSYLNWNYAWTPITIPAKSTASILFFTAQESNGSTATSAAQRLVQLPAEALAGLSTSDLASVVNFIIPTTPLSTVHPPSPAQALSGHVYAGDGTTAIPNAIVYAQSTDVLFGAGATATADATGLYNIPSLLANGFALESMDPSDGILSATVTGTFAAPVTPPAPQTKDIVFTNTGILQGLVKETGNGTFLKGTLYLNFSCTNYTQPQELPAFEALARTTAAAQPAAKAAAARSAAQPNASSYCGSLNGSFGPDGKFTYYTLPTGQTNLNLNVTLPQNESIPLPAGGGYFTTDIPAGQTNQFTITIPASGTIAGKVSNADGTAAANITVYAVPSDYNQSSGATTTTAADGSFIFSSLPLISYTIQATDPITNNTVSKVVSTTQDTTTVVNLQFIGKGSVTPTVRFANGNIAQNSLLYISTSTTPNYTYGGYTDVNGQYTFPNVPTGAFNIRAYYPGQNFYSTTPGTLTGNGNTLTPAVTLTPVGTISGHVTNQDGTPGSGEYVNIFDATNNFTAYAATDSAGAYAVTPAPADRTVTVQSYQATNTTNRTIIAQKFNQQVPGDGQTLIVDLRYPGLSSVKVTLLNTDGTHATSGSVYIKSTDAGTQNYSGAIGADGTYTFTQVVEGAFIAYANTDYTAFNAGSKAFTVAPTDDGNTVNVTITTSPTGSIKGQVYASDGTTLIRNSYTVKFTDIDTNTGTTVYPPSDGAGYTFTGVRNGASGYKLTAQLYGATTTASVTGSITTQGQTDTKNITLPVSSISGTVFLNDGVTPVPFAQLYSSQPIDAYGDTSGFSAQADANGTYQLSGPTTGTVTLHAYDSNDIVGTSTVVLTSDTQIVTAANVSLGPVGTVIGIAYDNSGHLLTNAYVQIQSSGNGNGFSTETETDQNGNFTFTDIPVGSLTLTVQDNSDNTIMATGSLQTNGQTVTINLGTPPAAVTEVFGTVYDGNSNPVPGATVTLTAASPSTVVVTATTDANGMYTATGLPVGNFVAAATFADGSSDGSTNAIITDPTTPIEVDIGLPQSGLVTGIVYDAHGNPVPGVEIEVDSTGDPNTGYLEDTANDGSFVFQVDPGQITITVTGPNNTVLGTASGILPYGGNVVINVTYPTPSAKPAPGKASVTKTQLTAPVAPHIMASLKLPATLPLAGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J3</accession>
    <name>E8X5J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3617</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581931.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3617"/>
    <dbReference type="EnsemblBacteria" id="ADW70620">
        <property type="protein sequence ID" value="ADW70620"/>
        <property type="gene ID" value="AciX9_3617"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3617"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_0"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="53"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="21045" checksum="D21A939004A6EB10" modified="2011-04-05" version="1">MDRLWTPWRYAYVTDEKPRGRKGVPEGLEAWPGEDTGCVFCNLIRSVDWAIETGMPVEEAEAHGFIVSRGEFGYICLNAFPYSSGHVLLVPYLHTDSLAKLPVAEAEEVIREAQRVEAALREVYDPAGINLGMNLGKAAGAGVAEHLHMHILPRWLGDTNFMTVVAETRILPETLDVTWKRLRAALDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S2</accession>
    <name>E8X5S2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV / VI secretion system protein, DotU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572718.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70806">
        <property type="protein sequence ID" value="ADW70806"/>
        <property type="gene ID" value="AciX9_4010"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4010"/>
    <dbReference type="HOGENOM" id="CLU_071818_3_0_0"/>
    <dbReference type="OMA" id="MLRHEVP"/>
    <dbReference type="OrthoDB" id="1650600at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DotU" evidence="2">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26566" checksum="BCC2949CEA80E402" modified="2011-04-05" version="1">MSTAATIPQAPPAARTNSLALSFQDVITVVLRMRYGAQRIPDAAAFRVSIRKMIAASVQEVRSLGYSDATSHMALYAIIGFLDESVLNSQDPVFADWSRRPLQEEMFGGHFAGETFFRQVADLLNAPESTEVADTLELHAICLLLGYRGKYAFGEGGEISGILSRIRDKIIRIRGPLALARLSAVPEVKIVAKRDKWLTSLYLAAACLIVLTIVLFAVYTLTLGSGLGSIRSAALFTPFTRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X694</accession>
    <name>E8X694_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4199</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70978">
        <property type="protein sequence ID" value="ADW70978"/>
        <property type="gene ID" value="AciX9_4199"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4199"/>
    <dbReference type="HOGENOM" id="CLU_1259956_0_0_0"/>
    <dbReference type="OMA" id="TIHAQEP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234435" evidence="2">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="22773" checksum="B493CA5525475C20" modified="2011-04-05" version="1">MKPMVMPLLPLALLFAALPQVPAAQPASAPAQNATQPTAALPAAPPPSTTLQPAVESLRATLILVRVEKWKAPAPIRDAAGTNLDSIQRDLDSTLPPLVKAADATPNSVTALLPVFRNINALYDVLLRVSNAAELTAPRPQADGLQKSLAALDQARRTLGDSIQTDATAQDKQITSLRAQLATALATPAPAPPPPPPAPTKPKPKKKKPTPKPAATPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J3</accession>
    <name>E8X6J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3860</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582164.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71143">
        <property type="protein sequence ID" value="ADW71143"/>
        <property type="gene ID" value="AciX9_3860"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3860"/>
    <dbReference type="HOGENOM" id="CLU_1903756_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14387" checksum="C1ECF19717768C8C" modified="2011-04-05" version="1">MVAECGADAVDGVIRVWELGYGMDLAEQLFNPAQCLDATDGLREGGGMDSNRRALQQEREMEVSLNREVICELALLPRGIAKTLVEGFLRNSSVLNDRLLVWACCQPGAATAKMPVIAEVDLLVPAHEGLICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L8</accession>
    <name>E8X6L8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71168">
        <property type="protein sequence ID" value="ADW71168"/>
        <property type="gene ID" value="AciX9_3888"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3888"/>
    <dbReference type="HOGENOM" id="CLU_027402_31_0_0"/>
    <dbReference type="OMA" id="MEYNSER"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="94"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="32743" checksum="E701607B63494593" modified="2011-04-05" version="1">MTERRACRLASQPRGTQRYRAIRREDEDALTQAIVRLASQYGRYGYRRITALLKRAGWRVGKDRVERIWRREGLKVPQKQKPRGRLWLNDGSCVRLRPERRNHVWSYDFVSARTHDGRSVRLLNLIDEHTRESLLVRAERRWSSSRVISALADVMVMKGVPEHLRSDNGPEVVAKDLRRWLAKTGAKTLYIAPGSPWENGYCESSNSKLRDEFLNGEIFYSMKELRVLAERWRVHSNTVRPHSSLSYRPPAPEAWFTPDGGYLNSEEAALNSSNGTNDRALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S0</accession>
    <name>E8X6S0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3944</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582238.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71220">
        <property type="protein sequence ID" value="ADW71220"/>
        <property type="gene ID" value="AciX9_3944"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3944"/>
    <dbReference type="HOGENOM" id="CLU_1319428_0_0_0"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="22793" checksum="4AFE239425815ED9" modified="2011-04-05" version="1">MPGRFVERKGSSDRVVPAFSPAVDPATAELAGISEPRSYPAGSVLVEQGEHPRQVMLVRSGVVRLSFTNPKGDEILLGLRSEGWWAGGVLAVLNLPSLCTMETQTECLLSCFSPVQFCVELNQRPALQQHFMTSQCRELLTMQQHSILNGSSATERLKSLQDERTKSVWQTVDPTLILRQSEAARLLSITPEHLSRLKKRRRSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W6</accession>
    <name>E8X6W6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pectate_lyase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582284.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71266">
        <property type="protein sequence ID" value="ADW71266"/>
        <property type="gene ID" value="AciX9_3992"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3992"/>
    <dbReference type="HOGENOM" id="CLU_016031_8_4_0"/>
    <dbReference type="OMA" id="VARNIHI"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233753" description="Pectate_lyase_3 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="41"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="534" mass="57275" checksum="6B447E49B10BB9B2" modified="2011-04-05" version="1">MPNQNRRDLLKFSGAGLAAALGTSAPSFAAPAPTKPNQHTFDIRAFGAIGDGKTLDTPAINRAIEAAAAAGGGTVLVSPGTYLCFSIHLKSNVDLYLSQGSTIIAADGPINPGDTAGYNGGKYDAPEPKTAWDAYQDFGHNHWHNSLMWGEDLHNLSITGSGLLWGRGLNPGHGNHVLPDGVGNKTIALKNCRNVIFRDFSILKGGHFGLLLTAVDNCTVDNLKIDTDRDGIDIDCCKNVRVSNCTVNSPEDDAICPKSSFALGYARSTDNVTITNCYTTGKYEIGSLLDGTFKIGKLANNKAATGRIKCGTESNGGFRNITISNCVCEGARGIALESSDGALLEDIAISNITMRECTVSPLYVRLNARMRAPAGTKVGTMRRIYINNLISYNSTSVQPGILAGIPSNLIEDVNLSNIYFHQVGGGDRKLAETIPDQGLKDYPDPTRMGGLPSHGLFLRNITRLDVSHIEFALATPDQRPAIWAENIQGMDLFRIKTPHTSGPNYVLRQVSDFTLSGSRGTRDSSFEKISDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W7</accession>
    <name>E8X6W7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582098.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71076">
        <property type="protein sequence ID" value="ADW71076"/>
        <property type="gene ID" value="AciX9_3790"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3790"/>
    <dbReference type="HOGENOM" id="CLU_030273_3_0_0"/>
    <dbReference type="OMA" id="QCIPHIS"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="194"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="428" mass="47428" checksum="96729BD4EB7B1C44" modified="2011-04-05" version="1">MQTDRRNLLKTALTAGAAAMAPGAALGQFLNAPRHGLPGNLQERYAKLDAVLQQPVFKREQFTSPVIIESVELLHYKNSYLCRVRSKDGAEGISISNSQQMAVLYPLFVDRIAPFFIGKDARDIESLIPAVTVYESNYKTQSLAIWVPIATIEFAILDMFGKMANKSIGLLISDKIYNPSISVYQANGERDNTAEEVIEHLKRDVALSHAKAIKFKLGGRMSHTESPKGRSEKLIPLVRKTFGDQMIISADANGSYTANQAIPIGKLMQEYKYAFYEEPVPFDWYEETKKVGDALEIPIAGGEQEPSTHNFRWLIANGGLSIVQQDMFYFGGMMRCMQVARMANAFGKQCIPHISSTGLGYLYMMHFVSAIPNSGPYHEFKEFNNTLPYKCATSTLVPDANGVIKVPTGPGVGVEIDPDYIAKHEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X8</accession>
    <name>E8X6X8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3801</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71087">
        <property type="protein sequence ID" value="ADW71087"/>
        <property type="gene ID" value="AciX9_3801"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3801"/>
    <dbReference type="HOGENOM" id="CLU_734952_0_0_0"/>
    <dbReference type="OMA" id="GIWWHEQ"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234265" evidence="3">
        <location>
            <begin position="25"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="47669" checksum="86D98367DF82BD60" modified="2011-04-05" version="1">MMNGWRSGAALVAAMFLLTAAGQAQDPEHATEKRMQQPGNAPDGKPRLAFLTHRLGSDHAEAISMIDMNGDGFVDLLSGAYWYENPGAGGGEWKQHQFRTVGIHNEFVSDCGEWVVDVDHDGLPDLVTTGWIANGLWWFKNPGPKATVAGEQWKGEKITDSFDTEGGAFADINGDGKPDVALAHYNRAGVMWVDFGKGKPKVHHVGDHVQDGHGVGIADIDGDGKADILTTHGWFQQVDADADKWVWHPDWTLGDAGFPILAYDVNHDGRMDLIYGQGHGYGLYWLEQGGTKEKPTWTRHTIDESFSQSHALALLDLNGGGPPVLVTGKRYRGHSGADPGSYDPNVVYAYRLPGFERTAISVNGTATIGTQIVAGDFDHDGDLDFATAGKLGVHVFENLKVNKVSKEMREEMQPINRKWPFPGEGGEVPQEDGPPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y3</accession>
    <name>E8X6Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3806</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582114.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71092">
        <property type="protein sequence ID" value="ADW71092"/>
        <property type="gene ID" value="AciX9_3806"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3806"/>
    <dbReference type="HOGENOM" id="CLU_038716_3_0_0"/>
    <dbReference type="OMA" id="EGNWPRD"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230825" evidence="2">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="373" mass="39998" checksum="1F1368BEBD730C38" modified="2011-04-05" version="1">MILTRRSILASLPAAAFAVKRGFAFQPDTNRIFIGTSGKISKGIYSAPFNATTGELGSITLAAEVATPSFLAVDRGHLYACTEGDGGKAKVSAFDVTATGLTPLNTQPSLGDGTTYVSARNHAVFAANYTGGSVTSFRTERDGSLSKPVSHFQYTGTGPNKERQEHSHAHSALPSPDGRFLLVNDLGLDRIHIYRIQPGTATLTPNDPPAFNTRSAAGPRHLAWHPNGRWLYSVNELDSTVDLLDWNPATGTLKQGPFVSTLKPDFPPNTAFAGEIMISPDGRYLYVGNRVASDTIAVFDIDHTSGTLTLSQLATNGGKNTRFLTPDPSGRWMLLCNQASNAIVVLPRDRGTGRLSDPRHAYPIDTPQCIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X741</accession>
    <name>E8X741_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4319</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572994.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71275">
        <property type="protein sequence ID" value="ADW71275"/>
        <property type="gene ID" value="AciX9_4319"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4319"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_0"/>
    <dbReference type="OMA" id="ICCDANQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="332"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="544" mass="59454" checksum="D51DB3B37792FA91" modified="2011-04-05" version="1">MLSAPAPDDDAERVATLHSYDILDTSPEEAYEDVTALATFFCETPYATITFVDKERQWFKSEAGFGVNETGRLDGFCACTILQPDPLIIEDTLLDSRFSMNQFVLDGPRIRFYAGAPIVAPNGHVLGTVCVFDDKPRQLASAQVSALKALARQVESLLEQRSTVSRLEAALKASQEAERRLGEVAATQQTMWKRLAEAAAIVDSSDDAILSKDLNGIITSWNLGASRVFGYTAQEMVGTSILRLIPAELHSDEAIIIGKVRAGERAEHFETLRLTKDGRRLQVSLTVSPIKDEQGFVIGASKILRDMSDRKRIEDSLLQAEKLAAAGRMASTLAHEVNNPLEAITNLLYLLRPLVTDIAGINYLTTAESEIARVSHIAKQTLGFYREYTTASPISLSELAQDAIKIYEPRCALKGIQILTSFQSDKILVLRRVEIMQVISNLITNSMYAMPSGGVLSLSVEDAASEGVIVIVQDTGVGIAAQNLPKMFEAFFTTRNAIGTGIGLFVVKNFVEGHGGRIEVESSQGMDDHGTSVRIYLPLRTFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X778</accession>
    <name>E8X778_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573031.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71312">
        <property type="protein sequence ID" value="ADW71312"/>
        <property type="gene ID" value="AciX9_4360"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4360"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_1_0"/>
    <dbReference type="OMA" id="YLAVQME"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26735" checksum="97B08C5857D9950B" modified="2011-04-05" version="1">MDDPVIAELQAKLEVATEALRLSEERSMPGHLALELMHEIRNPLEALGHFNYLTREDADDPAKVRAWADMAEEQMRTLNRIASQTLSFARVSTTSRTIDLVLVAEAAIRIHQRKMDNRKIHLVRNLPPELSATAHAGELLQVISNLLVNALDALSPDGIVTLRLSKRFGKARLLVADNGCGITDVLRDKVFEPYFTTKKDLGTGLGLALTRKIVARHGGTIRMRSRTSAGKSGTVFQISLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D4</accession>
    <name>E8X7D4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4419</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71368">
        <property type="protein sequence ID" value="ADW71368"/>
        <property type="gene ID" value="AciX9_4419"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4419"/>
    <dbReference type="HOGENOM" id="CLU_2464710_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="10421" checksum="1DFC095FAA554DE6" modified="2011-04-05" version="1">MRVRVFEESPLRAHRKYEFITSMWFDFADSTDKIDGVGPTQVSRQFSHEETRVKQVEIVRDMCTHPFSMSLVERQNCIGLLTKRRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G1</accession>
    <name>E8X7G1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573114.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71395">
        <property type="protein sequence ID" value="ADW71395"/>
        <property type="gene ID" value="AciX9_4449"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4449"/>
    <dbReference type="HOGENOM" id="CLU_911428_0_0_0"/>
    <dbReference type="OrthoDB" id="1006761at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="33158" checksum="F39493215A0F8499" modified="2011-04-05" version="1">MVHILTSSAAVLAFQAAPGVDWLTVFTQNLTNLTTQNGGALTSFGLTELSFISLMVLVNMVITWSTDTMTFGFHREPLRIGDLVQFLLRLICCLLAENYWSNPLPGASFGFNHLFSYIAQVLSQSIDQNSLTNLEALLKTLGDGTAAPAITAPLELLAYILIELMLGVVTMVVFLVNVSGFILYGVAALFGPVFIPLYMTKNFRGKFLHFVDVLVSFAMIRAVASAFIYVWAGFLQAFVLQTFQSDYSMKMWLANLIPCIALFGAFVINMLYIPSLTQIIFGGHAGAAEKVDAALAKVAALVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J7</accession>
    <name>E8X7J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4485</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573150.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71431">
        <property type="protein sequence ID" value="ADW71431"/>
        <property type="gene ID" value="AciX9_4485"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4485"/>
    <dbReference type="HOGENOM" id="CLU_069356_25_3_0"/>
    <dbReference type="OMA" id="HRWLLRT"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="22226" checksum="D5B880AB5A21794D" modified="2011-04-05" version="1">MGRPRNDTAVSHSAIMDAVSGLLEEKPARDLTMDAVARRAGVGKPTLYKWWPSKAALIMAMFHERFNAIPEVPGATTAEEALRTRVKHLAIQCNGLFGKVVADLIAEGQGNPSILEELYESHIRPRRASAVAAIERGITSGEFVAETDAELLLDAIVAPLYLRLLLRHPAVTERYGNQLIDTALLGVRNPKWKGGRRRRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K4</accession>
    <name>E8X7K4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573157.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4493"/>
    <dbReference type="EnsemblBacteria" id="ADW71438">
        <property type="protein sequence ID" value="ADW71438"/>
        <property type="gene ID" value="AciX9_4493"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4493"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_3_0_0"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="8925" checksum="240EE6E69A60CE21" modified="2011-04-05" version="1">MVSATIFEAKTSLSALVKKAQKGETVIITSGRQKTPVAQLQAIHIVSKKRLGALSTPGFLLTSAFYEPLEEEELALWNGEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K7</accession>
    <name>E8X7K7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4496"/>
    <dbReference type="EnsemblBacteria" id="ADW71441">
        <property type="protein sequence ID" value="ADW71441"/>
        <property type="gene ID" value="AciX9_4496"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4496"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032465_0_0_0"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="453" mass="50277" checksum="50E6EEAE7AA3CE61" modified="2011-04-05" version="1">METPDGGPSAKQRSGSEFQSWGRYPKYSGNIVPLQWQQNFPGRLGALDKGSLPVGMGRSYGDSCLLNGGNLLLTTGMNRLLSFEHETGLLTAEAGITLAEILDFAVPRGFFLPVTPGTKYVTLGGAIANDIHGKNHHVAGTFGSHVTQFELVRSDGSHRRCSKTENPDWFAATIGGLGLTGLIPWAQIRLRPIVSRMIDYEGIQFHGIDEFLELTRQAEKVEYTVSWVDCASTGKNFARGVFMQGDHSLIPGELKPSQEPKLVFPFDAPGFALNHTTVSLFNTLFFHKQMKPRVQALQDYEPFFYPLDKVLHWNRMYGKSGLLQFQYAIPWESAREGTIAILHEIAKSGLASFLAVLKAFGDVPSPGLMSFPQPGITLALDFPIKAGVTFPLFERLADMTRDFGGRLYPAKDAAMTASQFQIFYPQWEQLARFRDPMLTSSFWERVTGDRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K8</accession>
    <name>E8X7K8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4498</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71442">
        <property type="protein sequence ID" value="ADW71442"/>
        <property type="gene ID" value="AciX9_4498"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4498"/>
    <dbReference type="HOGENOM" id="CLU_2553497_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="9362" checksum="562995BEFC30808C" modified="2011-04-05" version="1">MISPSQFINYEPSSSEIAKQCNYKMCNPARYMLEQSEGSIVYLCAKHAFEFFRDERIREYAVLLKAATEKKAQSASANILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P5</accession>
    <name>E8X7P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4543</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573198.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4543"/>
    <dbReference type="EnsemblBacteria" id="ADW71479">
        <property type="protein sequence ID" value="ADW71479"/>
        <property type="gene ID" value="AciX9_4543"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4543"/>
    <dbReference type="eggNOG" id="ENOG5032TZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075807_0_0_0"/>
    <dbReference type="OMA" id="GRIFFEY"/>
    <dbReference type="OrthoDB" id="1448652at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="235" mass="26273" checksum="7D87FD8FBA6917A7" modified="2011-04-05" version="1">MATLAKPAFRLRSDDFFFPAMALLILAVVVYGFAQSYFLAGMVRAKLPNTLVHIHGALFVSWIFLLILQNALVALRKVRWHITVGILGVILPPLMIVAGFLTMLDSIRRVGTPIPPTILLVGDTQPLILFAVLITWGLLDRRKPASHKRLMLMSTLAIIAPAIDRWPILHHYIPATFAVFLSLPLLLLLYDAFTLKRIHRSTWVPYALMVVFSLTLIPLAQTPLAQRAVAWVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7R7</accession>
    <name>E8X7R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4570</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71501">
        <property type="protein sequence ID" value="ADW71501"/>
        <property type="gene ID" value="AciX9_4570"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4570"/>
    <dbReference type="HOGENOM" id="CLU_2990346_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="57" mass="6296" checksum="287552F68067257A" modified="2011-04-05" version="1">MTGFTANHCATVARAAEFIVTIDLMHYSRSERELTILRTPGSAIIVTKSNAIIRSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S9</accession>
    <name>E8X7S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4583</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4583"/>
    <dbReference type="EnsemblBacteria" id="ADW71513">
        <property type="protein sequence ID" value="ADW71513"/>
        <property type="gene ID" value="AciX9_4583"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4583"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382420_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="197" mass="21823" checksum="0A12330AB6ABB877" modified="2011-04-05" version="1">MYQGLLHRIVERSNMDPTRGLSLAITSVNHGEGVSYVTKTLASALETMLIPKVLHISLSSLETVKHDPSEIYLTLERRSGRPEELPRLSQQDSSLMSGLWHRGMESRSGVVQHLCTHSNVVLIDCPPLREDNNTLSVAPVVDGVILVVQAGGTTTTDILFAERKIVAAGGTFEGYVLNKAQTVMPKWFYKHFAKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V3</accession>
    <name>E8X7V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4607</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573256.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71537">
        <property type="protein sequence ID" value="ADW71537"/>
        <property type="gene ID" value="AciX9_4607"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4607"/>
    <dbReference type="HOGENOM" id="CLU_030155_1_1_0"/>
    <dbReference type="OMA" id="WHEYTRR"/>
    <dbReference type="OrthoDB" id="1033030at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="PTHR34496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="433" mass="48853" checksum="1394D10ADBB916CD" modified="2011-04-05" version="1">MGTGNELIFISIASYRDSQLIPTVEDLVEKADEPELLRIDICWQHGEEQPSLPFAEAPGICILDVPWQQSYGACWARAEAMKLWRGEQWFLQIDSHCRFIKGWDTKLIRMMQQTGSVRPILSTYANTFIPAADGTRAREALQGTPQLIALSGFSEDGLPKLKPLEIPGYSARERPMGARFLAGGFIFAPGSFVEDVPYDPDLYFFGEEIAMTLRAFTSGYDLFHPVESVAWHDYARAYATRHWDDRKPVVSEGASGATAWRDLDRLSRERVASLLRGETAGEPFGLGTVRTIEEYETHAGLSFRLRRMQDYTRRALEPPNPPLPSDWTAEIFTWMVRITVHRTALSACAFEEAGFWVVAIQDEDRHEIDRHDVTKAELSTIGDAPQIVLIREIHSGIIPESWSVQPFGRSAGWGPKISGKLDELDYSIIMEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z3</accession>
    <name>E8X7Z3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71577">
        <property type="protein sequence ID" value="ADW71577"/>
        <property type="gene ID" value="AciX9_4647"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4647"/>
    <dbReference type="HOGENOM" id="CLU_076076_0_1_0"/>
    <dbReference type="OMA" id="WWYQLTA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="24315" checksum="7920AB499D274DC8" modified="2011-04-05" version="1">MRSVKRTYVYVDGFNLYYRTLRKTKFKWLNLEALVRSLLDDENEIVCIRYFTAPVSGKFDPGVPVRQQRYLQALRTLPTVSIHEGNFLTRAKIRPLVHPAPDGPTHVEIWNTEEKGSDVNLATYLIHDAWRDLFDVAVVLSQDTDLNEPVRIVRDEIKKSIGVIILDGKAPGKLSTFGSFVRHITHADLAASQFPDIIPFGQRGKAVERPSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ5</accession>
    <name>E8WVQ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2557</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580899.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2557"/>
    <dbReference type="EnsemblBacteria" id="ADW69584">
        <property type="protein sequence ID" value="ADW69584"/>
        <property type="gene ID" value="AciX9_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2557"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_2_0_0"/>
    <dbReference type="OMA" id="FNDPERH"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="15000" checksum="FB3B0BCD5C1E68E9" modified="2011-04-05" version="1">MSALFRIGDLAKQAGVKVVTIRYYEQAGLMPVCERTSGNYRVYAQEHLQRLNFVRRCRELGFTLVQIKDLLQLSACQSPTCADVCNVATDHLKEVESKITDLKRLAFELRRIGSSCDGKQSSAECRLIASLTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVT2</accession>
    <name>E8WVT2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582000.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3690"/>
    <dbReference type="EnsemblBacteria" id="ADW70691">
        <property type="protein sequence ID" value="ADW70691"/>
        <property type="gene ID" value="AciX9_3690"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3690"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_0"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="133" mass="14047" checksum="E4CEE2D05C1E5342" modified="2011-04-05" version="1">MSDQTKTVISTTNAPAAIGPYSQAILTGDTLYTSGQIPIDPKTGAFVPGGITEQTTQVFENLRAVLDQAGFNLAQVIKTTVFLKDLGDFAAMNEIYGQYLAPHGVIPPARSTVQVAALPKDALVEIEVIAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU2</accession>
    <name>E8WVU2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3700</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582010.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3700"/>
    <dbReference type="EnsemblBacteria" id="ADW70701">
        <property type="protein sequence ID" value="ADW70701"/>
        <property type="gene ID" value="AciX9_3700"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3700"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_3_0"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="15683" checksum="FEFD0D70F2315FE8" modified="2011-04-05" version="1">MNAESSPDLEISVLKLHPYAQLPRYAHTGPYGDLAADLHAVEPLTLAPAETRAVPTGIALGLPDGFGALVEDRSGLASRGITTLAGVIDPGYRGEVKVVMTNLSAIPHTIAAGDRIAQLRIVRRIEAAFTEVSTLDQTPRNQGGFGSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV5</accession>
    <name>E8WVV5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3713</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582023.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3713"/>
    <dbReference type="EnsemblBacteria" id="ADW70714">
        <property type="protein sequence ID" value="ADW70714"/>
        <property type="gene ID" value="AciX9_3713"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3713"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_0"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="197" mass="21360" checksum="D9CDE1E6B66B22E8" modified="2011-04-05" version="1">MLILASASPRRHELLKQAGFDFTVEVANINETPLEGEAAAAYVQRLAVEKAQAVCGLHRDKETESYVVLAADTCVVADGQILGKPTDIMDARRMLALLSGRTHAVMTGVAAVFFGPEVKSRTIADVVITQVTFDLMSEQEIASYVATGEPMDKAGAYAIQGYAARWIPRIEGDYFNVVGLPIARVVHLLDQVQVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW0</accession>
    <name>E8WVW0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3718</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582028.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3718"/>
    <dbReference type="EnsemblBacteria" id="ADW70719">
        <property type="protein sequence ID" value="ADW70719"/>
        <property type="gene ID" value="AciX9_3718"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3718"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_0_1_0"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="23496" checksum="E0BFB503C1D8CFA7" modified="2011-04-05" version="1">MTWTSQFGKGSGWLLQKIVNGLAISKISPNVLTFIGLIINIVAALFFGFARGDHAVRYFFYAGLIIIGAGVFDMVDGRVARQTNQVSVFGAFFDSVIDRYSDVCIFFGLLVFYARGNRLFYVGLVAFVMTASLMVSYTRARAEALIGSCKVGFMERPERIVCVILGALCNRWGVMAPALWVLALFSTITVIHRIRYTYNETERRKRLNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX1</accession>
    <name>E8WVX1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_3729</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582039.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3729"/>
    <dbReference type="EnsemblBacteria" id="ADW70730">
        <property type="protein sequence ID" value="ADW70730"/>
        <property type="gene ID" value="AciX9_3729"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3729"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_0"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="462" mass="50975" checksum="B02AC0E973E299ED" modified="2011-04-05" version="1">MATYPRLLNPEDDSRPASLHAEQTILGAMLVEPLAIVDATMLLKADDFSLDSHRKIYEVMIHLSEVGYAVDIVTVSEELSKRKQLDSVGSRPYLAGLSEGLPRKLSIESYVRIVRDKSLMRQLMSVCDAGMMEASDQSLEAIDVLNQVESRLMEISEHAITGGFSGISDIVKSSFGSIEKLYEQGREVTGLRTHYTEFDKMTSGLQESELIIIAARPSMGKTAWAINIAQNSAVKDGMVVAVFSLEMSKESLLRRMLAGEASVGARKLQTGFLGRDDKGKLQDALERLMESKLYVDDTPGITLAEMRAKARRLKQQEGRLDLIVIDYLQLMSGSTGGKKGPENRTQEVSAVSRGLKALAKELRVPVVALSQLSRGSEQRTGDKKPLLSDLRESGSIEQDADVVCFIHREEYYDRENEDLKGKAEIIIAKQRNGPTGSVQMAYIADYTRFENLDTAHGGDGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX9</accession>
    <name>E8WVX9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cna protein B-type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3737</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3737"/>
    <dbReference type="EnsemblBacteria" id="ADW70738">
        <property type="protein sequence ID" value="ADW70738"/>
        <property type="gene ID" value="AciX9_3737"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3737"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NGGCPSI"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="594"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1149" mass="122019" checksum="0F957300056B27E8" modified="2011-04-05" version="1">MLAAIPPRRTLSWSLMHSFRRSELYAATLAFSRLLQALGVLTALLLASPPDSAQSPVDGAIQGVVLDSRGAAVPHAALVLRNTDTGATRLGSTQSDGSFLLPHLPPGHYTLRITATEFVEAREIDLTVSLGETADLRTTLHLANLTPTAQTTDDTLARLSPALESTLTDSDLAQLPANAHRWQDLALTTSGAAPDQDDDGLFSANGLPSTQNSVLLDGASQNQSFSSVPAGSGSDAAPDPEADSDSAELATGPSHGLSRGRHAGIAYSFSQSAVREFRVTTQTYSALTGSAAGAILTSVSKSGGAIPHGSVFFLLRSQALAAANPLSLATTYNNGVATTQTIKPHDLRESYGGTMGGPIPHTAGMFGFYSFDQQRRGFPAISSPADPNFYTLTPTQLALLANRGVTRAASTAALTYLASITGSTPRRADQTLNFARLDWHATPHEEFGLQYNRVRWNSPAGLTDAPVVAVGRASLGNASGSLDAILARVTSTLSTRWINQFRLQYARDKQFETPQPNLPQEPGIGPGGQAPEVNIGPNGLLFGTPASLSQQAYPDERKLEAGDILSLQLGHHLLELGGSVSAVHDRVATLANAAGTFRYDSTRTTANAGGLVDFITDQTFNVNAYPNGGCPSINAAIHLFCFTSFSQSFGEQLAAFSTSEWAGFAQDTWRIRRNLNLTLGARYEYILLPIPTTPNSALDALFGTRAATSIFPEDRNNIGPRAGIAYEPFGNGHGTIRLGYGAYYGRLPGATIRSALADTALTNSTTRIRITPSAVTACPQVANQGFGYPCAFLTRPPAIVSSTTSAMMFDRHFRLPVVQQASLSLEGSLGRHASLSATYILNIDHQLQSSTDLNIAPSTSAAEFQLQGGTASPGVLSGETFVVPQYTARVTPTFGPVTDILSTANASYNALAVTAQMRGWHGLSARGSYTWSRAIDYGANLSATPRTNNQLDPFTNGYDKGLSALNYPQILRIVAVYAPRIHIQKRTTRTFLDHWELAPILLARSGRPYSYQLYGGPSLSGGHQSINGSGGALYLPTVGRNTLRLPSAINADLRISRAFTPGGHIRSEPLKLRLSAEIFNLPNRTNLSSVETRAFLVGTKTAGITPLVFQDAAAIAAEGLNTQPFGTPTAASTSLARERQIQLSLHLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA0</accession>
    <name>E8WWA0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68483">
        <property type="protein sequence ID" value="ADW68483"/>
        <property type="gene ID" value="AciX9_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1425"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803461_0_0_0"/>
    <dbReference type="OMA" id="IEMHETH"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="15006" checksum="E22AC737EA132C47" modified="2011-04-05" version="1">MMPGLLALGVLGGVEAEGQAATTGKELKELSSGVFKAGPEKKGSQAKHVSRAFGSGLLKAGNIRLEMHESMQDAGAEHEPVGTHLHNEIWFVQKGTASLFINGTEHTMEAGDVGLVCAGDKHWIKNVGDGELSYFVLAVGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF8</accession>
    <name>E8WWF8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="5" type="ordered locus">AciX9_2597</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580937.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2597"/>
    <dbReference type="EnsemblBacteria" id="ADW69622">
        <property type="protein sequence ID" value="ADW69622"/>
        <property type="gene ID" value="AciX9_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2597"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_4_0_0"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="OrthoDB" id="1598407at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="107"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20793" checksum="9A102325C6800393" modified="2011-04-05" version="1">MSIKSDRWIREQAQEHGMIKPFSEKQVKDGVISYGLSSYGYDLRVSDEFKIFTNVNSAIIDPKAFDERSFVTVTADSVIVPPNSFALARSIEYFKIPRDVLTICVGKSTYARCGIIVNVTPFEPEWEGFVTLEISNTTPLPARIYANEGLCQILFFQSDEVCEVSYADRKGKYQNQQGIVLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ4</accession>
    <name>E8WWJ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis MoaE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2633</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580973.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2633"/>
    <dbReference type="EnsemblBacteria" id="ADW69658">
        <property type="protein sequence ID" value="ADW69658"/>
        <property type="gene ID" value="AciX9_2633"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2633"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_1_2_0"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16179" checksum="FCC5ECB633361577" modified="2011-04-05" version="1">MRVEILDEVLPTDAVMAEMKAGADGAVCVFDGIVRDNTRGRKTLYLDYEAYREMALTQMEGLAAEAIVKFGVRDVALLHRLGRLVVGETSVLIVVASAHRGAAFDACRWLIDTLKKQVPIWKKETFVDGVIWADGEPFPTEVALNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU7</accession>
    <name>E8WWU7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0353</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578753.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0353"/>
    <dbReference type="EnsemblBacteria" id="ADW67425">
        <property type="protein sequence ID" value="ADW67425"/>
        <property type="gene ID" value="AciX9_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0353"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952371_0_0_0"/>
    <dbReference type="OMA" id="DWIEYML"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230008" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="150"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="32261" checksum="8E3C5E08BD52C6B8" modified="2011-04-05" version="1">MRFLALTALALLTLPTLAQPPRPKITGIAYVRFYESDLPAAKAFYAQRLGLPEIDTPQGAVFTVGARQSIRIAPLPSPAPPNRLAEAAFLTPDIPGMKRFLTAHHIPFEPISPAEIRLKDPEGNPIGFLSEQHLPAPAHVATTQVASATRIIHAGWGVHSAAAEDAFFRDLLGFRPYWHGGMTPDKTDWISLQVPDGQDWIEYMLEYSPTDSLKKLGVLDHVSLGVVKITDVTDRLVANGWTDPDTRKSQIGRDGKWQLNVFDPDQSRIEFMEYTPTRKPCCSDFTASNPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV2</accession>
    <name>E8WWV2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase active site domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0358</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0358"/>
    <dbReference type="MEROPS" id="S09.021"/>
    <dbReference type="EnsemblBacteria" id="ADW67430">
        <property type="protein sequence ID" value="ADW67430"/>
        <property type="gene ID" value="AciX9_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0358"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017120_0_0_0"/>
    <dbReference type="OMA" id="FPIQSER"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233442" evidence="2">
        <location>
            <begin position="29"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="665"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="823" mass="88740" checksum="89AB3771C35FC59F" modified="2011-04-05" version="1">MAMKLLGAAALVFSVAVVPVAGFQIARAQTATAYQKPPAAIEQLLDAPETPLVSVSPNRKMLLIEQPASFPTIADVAQPRLRLAGIRFNPVASAPAGSGDSYSISLKLQGVEGGAARAVTGLPAKLKATNAMWSPDSKHVVFVQRVDASAPGGPGLQLWVIDAASGAAHRVGLVKLNGVLGSPCAWMPDSAAVLCHVVPVRGAAPRLSDVPAGPNVEENLGKATPAPTYEDMLKTAQDADQFEYYSTSQLAIVPLTGPVKLLPVKGLIDTARPSPDGKYALVDVIHRPFGFTVPYERFPRKTEIVTLKTGTAKDVYDRPLVDNLPISRDAVEPGPRDYQWRSDVPATLVWVEAANNGMPVKEGVADRIMALPAPFEGKGEVIYEASLRISRGGFGGARGIEWGNDHLALVTEARFSDRKTMMVAFDPSAVGKTKTLYAGSSQDRYKNPGRPMTMMNATGQMVLKLTGDGTGIYFSSLGSSPTGDRPFVGVMPVGGGAEKILVRSADPYYDEPVALLSDDKVLIRRESAARSPNYFAEALTGGAAVQVTQFASPYAGINMPTKQLLKYKRKDGVDLTATLWVPYGYDKSQGPLPTLMEAYPAEFKTRSAASQVAGSPNRFPRINWGSPVYFAQVGYAVLQDASIPIIGEGDSQPNDTYVEQLVDGAKAAVDYGVSLGVVDPKRVAVMGHSYGAFMTANLLAHTNIFRAGIARSGAYNRTLTPYGFQNEERTYWQDPKVYFDMSPFSYADKIKTPILLIHGEADDNTGTYPIQSERFYAALKGQGATVRLVFLPLEAHHYVAHESLQHMLWEMDRWLDTYVKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX14</accession>
    <name>E8WX14_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1522</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579894.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1522"/>
    <dbReference type="EnsemblBacteria" id="ADW68575">
        <property type="protein sequence ID" value="ADW68575"/>
        <property type="gene ID" value="AciX9_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1522"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234891_0_0_0"/>
    <dbReference type="OMA" id="YATYLTG"/>
    <dbReference type="OrthoDB" id="61017at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230392" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1884"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="4">
        <location>
            <begin position="1565"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="4">
        <location>
            <begin position="1670"/>
            <end position="1755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1945" mass="194225" checksum="4B896006C03D6EB7" modified="2011-04-05" version="1">MMKRLKAISAIAGLLLLASPMLARPAHAQANQTQQLAFAGLHATGAQGQFNAIKTDSAGNLYLLLDQKDGVRVLKTDNAGNAILAQALLGAQGDIGLAIALDPAGNVYVTGTTTSTTLTGTGGAAIPARTDASTNSFVAKFDPSLNPLFVTFTGGSRIAASAIAATADAVFVTGSLFSATLPVTSSGFQQTPATGSFQNGFVERFSSDGSTLVYATYLTGTSGDTTPIAIAADPLDNAYLAGATTASGFPTAAALVPAMVANPSGFLTRLAPAGDVLIFSTFIPGQGLSSVALDTTGQTLLVSGSIALGQFPVSTPTQPLLPLNYQVLLRLPLDGSAVQSSTIIAPGQQSSLAPAPDGSVWVDGTFTAPLLPSPALATLGGAYAVHVTPQNIIDQTARFGGLPNASATYASLPATITSIAIDPTGSPLIAGSVQPTASSALLATETYDLPLVNNLTTALPSTIRAAEVTAATCNGSLCAGSAAYLAKLNIATSAPSLVFSADDSPWLILRNLGSAPATNLQLTTTADTLATNCPITLSPGGECDMLLAGSAVATITATASNAASQSVTVAAFTGPTSTIVFAPKELDFGLQTSANPPGTRTIAVSNLGTANQTFTSAIDSSAKTASPFTEQASDCPINGDNSIKLLAAGATCHITLALTASTSSANDGLLSADWSIGSRDVVLTGYSQAASLSVSASELDFGTQYPGGMRLPRSVLLSNSSSVAIAHATATLPASSPFTVTDSCPTTIAPGTVCGIQIGYLSATVPSKDTATLTLDQGLSVLLTGQTLAQPPAGGGTSSTLGVSPSSVTFATSVVVTGVSGNNQTVSVINSSSAAVPITLAIIGDFTQVNSCGTSLPGGQTCAIAISFVPSQPGVRQGLLSIGSGTGINPIYVSLSGTATAIVPVSNGVIAFGNQPVGQPAAQFFKVAQAFTSLSATATGPYKLDFIADLGYGPGQPPSSAYTSTVTGACATCYLAVQFQPTAAGAQPGSLTLSSNAAGVPYTFSLTGTGLPLTGLLLSPLAQDFGSIPVHNVSGAISFTLTNQSVSGANVTIPTPTLAGDFALNPNGSCGTSLAPTASCTFALSFSPTATGARTGSLTFTSSDGTVTATLTGYGLPDPGIAINPLGLTFNNAPGPTATQQTVTLTNTDSVALQIGTPTFATSRFQAADGCSSLAIGANCTIAITFLPSTAPVLDSLTLPVTRAGSTSPVLYSVALNGAYTVSTAALQITPSQTDFGPTAIATQGPIRQFTLNNLTAKSLTLNLIIPRQFALSGTPCLTLAPSASCTIQLQFDPLTNADITGTLTAQATPTDGSAPSQAMAYLEGFGTSQGGTLSIIGGLQTGSILNFGQVTSGQTLARTLTLANTSAASAVTIRRITSGPPFLSTTTCTTSLAAGQSCSVTLTYAPSNQVATGTASPASTSDSGLLTIESDASSSPDLIHVIGQAGPLVVSNPSGTTPLATYTLSQSSFAFAQAQMGTATARQGVTLTNTGSIALHVLSATTTADFTTQNGCATILPAATCSLSVAFTPQTTGTHVSALDIATDSTTSLEFISLIGTATASPVSLSPTSLDFGPLVVGVSTTLPIQVTNSGSTAATITASSITGDYTQAGTCPPIGSPIPANSSCTLQIRFKPTQTGTRPGTLSLTTSASTIPLTASLTGTGIQSLLTSTPASLAFGNVTLGSSASMTVTLANIGTAPVTNITATISGDYTVTKPCTAASLAPNTNCQIQVTFTPTAIGLWPGTLTITSSDHSSPLLIPLSGTGIQLPSFTFTASGASSATATVISGTPATYALAVTPIAGFTGPVALTCASVVPGLYATCSIQPSTLTLAGSAQNSTVTINTITTLQARRAPLPSSTLLCILLPGLMLLWRKNRTLRQRATLTLLALSFTAFAITSAGCAGGAPARTSNVQSTPPGTYQYQVTATSTSGTQITQTVTLNLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX66</accession>
    <name>E8WX66_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2684</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581023.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2684"/>
    <dbReference type="EnsemblBacteria" id="ADW69708">
        <property type="protein sequence ID" value="ADW69708"/>
        <property type="gene ID" value="AciX9_2684"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2684"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034536_0_0_0"/>
    <dbReference type="OMA" id="IPRNSWG"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="462" mass="50457" checksum="F211FE3F7985C19C" modified="2011-04-05" version="1">MSRMGGRREFLRRAGVLAAGVGVAGRGMLGQAVGEQQTPAAKPVPAMVAANAKWKSTWSDALTVLAGNIKMTPHYPRPLLFEGAVYGGCWQECGPMEGLVYSSLGQYVPAMAGVPTPVQVAKDNHMAFFALQTAEGQIPSSIKATASPEGGLGQIQMVVPIAATAWELAQATGDDELLVAAYKAGGKWDAWLRQYRDTRKTGLVEGFCTYDTGHDNSPRWKGIPNRCPDADARKFPALPGMPRLCPDLSATVYGGRVALAAMARELGRPDEADRWLADAETIRKLIIAKLWDPKDAAFYDLDSDNKFVRVRGDLISRVLGEHVLKLSDAGDRQIFNAVYTRQIVNPKAFWAPYPLTSIAMDDPAFVRPIPRNSWGGASQALTALRVPRWMPHYGKHADFEHLMRQWCEAISRHGEFRQQMDPETGDFTQADPSGYSPAALVFLDFARRLGRADLGAEGKTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXI3</accession>
    <name>E8WXI3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">AciX9_1546</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579918.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1546"/>
    <dbReference type="EnsemblBacteria" id="ADW68599">
        <property type="protein sequence ID" value="ADW68599"/>
        <property type="gene ID" value="AciX9_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1546"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_0"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="50465" checksum="D42BC074F93234B1" modified="2011-04-05" version="1">MFENLSEKLQRSFKTLRGQGTITEENISDAMREIRLALLESDVNLEVVKDLVEHIRVKAMGTQVTTALSPSEQIVKIVHDELVTLLGKDIAKFRTASQPPSVVLMAGLQGSGKTTTSAKLAQWLKKGGHRPMLVSVDVYRPAARAQLAVVAKSTGVNLYEGKLDESVQNGTPEVLRLAKEAKKEAANFGCDILIVDTAGRLGIDAVLMDEMAELKKLLNPSEILFVADAMTGQDAVNSAKAFNDLLTITGAILTKMDGDARGGAALSIRQVTGAPIKFLGTGEKPDAFEPFHPDRIVSRIMGHGDIATLLERAESTLDKGKAEAFAKKALGGQGFTLEDFREQLRQIKKMGSMKSILKMLPSVGPFAGMAQAAENVDESQFTRVESIINSMTNKERQNADLINGSRRKRIAAGSGVTVAEVNNLLRQYAQMSKMFKTMGGGMGGGMKAQQRLMSQMQQQKQRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXJ0</accession>
    <name>E8WXJ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligopeptidase B</fullName>
            <ecNumber evidence="4">3.4.21.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1553</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.83" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579925.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1553"/>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="EnsemblBacteria" id="ADW68606">
        <property type="protein sequence ID" value="ADW68606"/>
        <property type="gene ID" value="AciX9_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1553"/>
    <dbReference type="eggNOG" id="COG1770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_0"/>
    <dbReference type="OMA" id="NMGAGHG"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="471"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="689" mass="77299" checksum="3719D39EA564C06B" modified="2011-04-05" version="1">MSDHAALQPPVARRQPIPTTLHGQTLHDDYAWMRDKSSPEVIAHLTAENAWTAANMAPTEPLQKTLYAEMLSHIQETDESVPYPSNGWFYFTRTLEGSQYPIHCRRQTFDATTPEHILLDVNKLAEGQAFMAVGGLSISPDNKLIAYSTDNTGFRQYTLHIRDLSTNEDLPDTALRAGSFTWAADSSTLFYTTEDEQTKRHDKLFRHTVGSTERDPLIHEETDERFNLGVGRTSDRKYIMVEAGSHTTSEYRFFPSADPTAPLTLIAPRQDDQEYYPDHRDGLFYIRTNDTTRNFRIVTTPVATPDRTNWTEFYTAAPNIPIEDFDLFQSFCVITERKSGLPTLDVYDLTTTLTNRREITFPEPTYTAGSHVNAEFDTRVFRYSYTSLVAPASVYSYDIATNTSTLLKQQAVPGGFDPANYASERLWVPATDGVQIPVSLVYRRDQFAKDATNPLYVYGYGSYGYSLPVGFSSTRLSLLDRGLVLAYAHIRGGGELGDTWHDAGKMMVKRNTFTDFIAVTEALVQQKYGSPKRVAIEGGSAGGLLMGAVLNARPDLFRAVLSHVPFVDVMNTMLDATLPLTVAEYEEWGNPNEPEAFAYMLTYSPYENLDALAGKPLPSILVKTSLNDSQVMYWEPAKYVAKLRTLKQDAPPLLLHINMEAGHGGASGRYDYLKEVAFDYAFLLRELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL7</accession>
    <name>E8WXL7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1580</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579952.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68633">
        <property type="protein sequence ID" value="ADW68633"/>
        <property type="gene ID" value="AciX9_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1580"/>
    <dbReference type="eggNOG" id="ENOG5031XQ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649739_0_0_0"/>
    <dbReference type="OMA" id="PTGNGLC"/>
    <dbReference type="OrthoDB" id="1813002at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="17016" checksum="01207582B1CCC3C0" modified="2011-04-05" version="1">MIDEFEYSHGKSAGDLGRESMWFAAHALVAVLVLATVVFIISLTGPSIEASGPKILGTALALLMPMVVGFIMMKVEPNPIAKYVWIAGLVFFSIICVWVLDLPTGNGLCEKCGAAEKLYRTFFDISNGSGLMGGDGLLVGTWIPLSMIGYAIGAKLALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL9</accession>
    <name>E8WXL9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1582</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68635">
        <property type="protein sequence ID" value="ADW68635"/>
        <property type="gene ID" value="AciX9_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1582"/>
    <dbReference type="HOGENOM" id="CLU_2633122_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="7616" checksum="E6DBB99263E9DAD4" modified="2011-04-05" version="1">MLGIDGFGRDKCKGPGLKPAFFWALDGGLKPPSNPNGNGNGNGNGNGNGNGNGNSKSNGNGNSKSNGNGNGNDLLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR4</accession>
    <name>E8WXR4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2735"/>
    <dbReference type="EnsemblBacteria" id="ADW69759">
        <property type="protein sequence ID" value="ADW69759"/>
        <property type="gene ID" value="AciX9_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2735"/>
    <dbReference type="eggNOG" id="COG1637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760045_0_0_0"/>
    <dbReference type="OMA" id="SRTWLID"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="38860" checksum="36CBAB0E7E65819F" modified="2011-04-05" version="1">MPIRSAIWKVGAKPEPLTESLLAREQILEDMIVAAPQILSDEWMLIGRQEDTGFGGRIDLLAISPDGSLVLIELKRDRTPREVVAQALDYASWLSNLRADEIAEIYDRFAPNRSLEADFKARFALNLDEDMLNQSHEIVIVAASLDQSSERIVNYLNERNISINILCFQIFSHSGEQLLSRSWLLDPVRSQVSSAATTYSESEPWNGEFYCSFGEGESRSWEDATQYGFLCAGGGVWYSRTLGLVKPGDRIWVKVPNMGFVGVGRVTGQASPAAAFTVKDSNGIVVPILDVAKKGMYHREFADDLEKCEYFIPVDWLQTLPVREAVWEIGLFGNQNTVCKPTTPSGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR8</accession>
    <name>E8WXR8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_2739</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581078.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2739"/>
    <dbReference type="EnsemblBacteria" id="ADW69763">
        <property type="protein sequence ID" value="ADW69763"/>
        <property type="gene ID" value="AciX9_2739"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2739"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005503_0_0_0"/>
    <dbReference type="OMA" id="YLHVPDM"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233472" description="Tricorn protease homolog" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="883"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="786"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1119" mass="120854" checksum="633E7BD24B7A4F13" modified="2011-04-05" version="1">MRKVLSVLAASFAVAPFAIAAPPPANPHLLQRPALTQTQIVFNYAGDLWTVDRKGGKATRLTAGVGIETAPVVSPDGSTIAFSGEYDGNTDVFTIPIAGGIPKRVTYHPSIDVPVAWTPDGKQIIFRSDRQATSRFAQLFEVAPTGGVAKLLPLPLAYQGQISADGKMIAYSPLAPAFGFNYTSYVSWGNYRGGRAGTVNITSLPDLTTTAIPHEKASDFSPVWFGNKVYFLSDRKGSVSLFSYDPATKAVTEALHNTGSDMHSLSAGPGGLVYDQLGEIYLFDPASGKSHMIEIDVTGDLPEVRERIENVSAEIEHAGISPTGIRAVFEAHGEILTVPVKHGPTRDLTNTPGAMERWPAWAPDGQSIAYFSDESGLYALHVASQNDDGPVKKFPLAAEAAYYFQPKWSPDSKKIAFYDNRLNLWMLDIVTGKLSHVGENNFFSGIDRDYAWSPDSRWLAYSRTEDNHLSCLYLYSTETGTSTVFTDKMADSGNPAFDRNGKYLYFTASTNQGGTAFGLDMTSDLLRTTRNLYALVLAADAPSPVAPESDDEKTLAEAKEHNKDMGDEPTTTPAKPAGQKPDEAAEAKASMPAVPTTKPTKIDLAGIETRVVALPLPSRRYTDLDSGKAGGFFFVEHSEGGGPGTLKRFSLESRKAETISDRVESYSLSANGEKVLLEQPHGGDGGTPNYSIVPATPAPAGGKPGGDSGVLNLADMQIRTDPAAEWRQMYHEVWRVERAYFYDPHFHGVDTVADEKKFEPYVRSIASRTDLNYIFQEMLGPFSVGHLRGNGGAIPEAKRVPGGLLGADYTIVNNQYCIAKLYDGGHWNPNMTGPLTQPGLNVHVGDCITAIGGKPLTAAEDIQRPLEGTAGHAVTLRLATGSAPARDITIIPIRSEASLRNVDWIESNQKKVDQLSGGKLAYVYLPDTGEGGFTNFNRYYFAQDNKQGAIIDERFNAGGQVADYIIEAMKRPLLSFWQPRYGAIDRTPTAAILGAKVMITNEFSGSGGDAMPYLFRQQKIGPLVGKRTWGGLVGIGGIPVLMDGGNVTSPSFGQFSPSGVWDVENKGVEPDFPVDQDPKAVSEGHDPQLEKAVALALEGLEKSPVPAPKRPPFPDYHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT6</accession>
    <name>E8WXT6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2757</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581096.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2757"/>
    <dbReference type="EnsemblBacteria" id="ADW69781">
        <property type="protein sequence ID" value="ADW69781"/>
        <property type="gene ID" value="AciX9_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2757"/>
    <dbReference type="HOGENOM" id="CLU_2665960_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8448" checksum="33344A0CD2BF3153" modified="2011-04-05" version="1">MTISHKSQYLLVTAAILTASVIQLVRGYKPYIVIIGAIAFIFIGNLTVYLAGSKQRAIQQQRKRDYYAGLRDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY02</accession>
    <name>E8WY02_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0469"/>
    <dbReference type="EnsemblBacteria" id="ADW67541">
        <property type="protein sequence ID" value="ADW67541"/>
        <property type="gene ID" value="AciX9_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0469"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="MNNSRIV"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="224" mass="24830" checksum="5469AF76421AD489" modified="2011-04-05" version="1">MIHKVILADNQSVFRTGAARILAIEEDFRIIGQCDDQARLFKAMTTSSNATVLFAASLNVDLAALVSTAEEAGARTVVILENDTSPQSYSQAGVRGILHRDVSNTDLLRCMRLVGRGERYVQQRAAVKTAAFETDLVAERVRERLTPKELKVVALILQGYKNRDIAEELHNSEQVIKNYLRSIFDKTGVSDRLELALFAMHHKLLTTAPARTPMHDESAARVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY13</accession>
    <name>E8WY13_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578880.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0480"/>
    <dbReference type="ESTHER" id="acism-e8wy13">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67552">
        <property type="protein sequence ID" value="ADW67552"/>
        <property type="gene ID" value="AciX9_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0480"/>
    <dbReference type="eggNOG" id="COG0429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_0_1_0"/>
    <dbReference type="OMA" id="RNDPFVP"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="37457" checksum="02029E84BD7811C1" modified="2011-04-05" version="1">MPIFEPTDFHPRRFLSNGHLQTIVGNFLPRPSHLPPPEPQLVEVSPATRDYISSQVLCQCHWQPEEVRAERMTVIILHGLEGSANSQYVVGNANKMWLAGFNVVRMNMRNCGGTEALSPTLYHSGLSADVDHVMRFFIAQHGLQRIALVGYSMGGNLVLKLAGDLADQAPVQLHAVVGVSPALDLGPSADALQSPLNRIYERRFLRALTKRFRRKAQLFPHVYDPARADGLTSLRDFDDRITALYSGFRSADDYYLRASAARVLSRIAVPTLILHALDDPFVRITQESNAAIAANPAITFLEPAHGGHCAFLATPDPAHHDDGYWAESTLLRFIHSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY22</accession>
    <name>E8WY22_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0489</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578889.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0489"/>
    <dbReference type="EnsemblBacteria" id="ADW67561">
        <property type="protein sequence ID" value="ADW67561"/>
        <property type="gene ID" value="AciX9_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0489"/>
    <dbReference type="HOGENOM" id="CLU_2301867_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="11015" checksum="9468A2846138409F" modified="2011-04-05" version="1">MFQQAPRPARFDLNLALTFAGDEAVLEGHCVNVSASLRNGEISLLVGEFYISIKVRVARIQGFDAGLAFIIETDNDRHASRLLVEFATSQNQPERQPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY26</accession>
    <name>E8WY26_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578893.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0493"/>
    <dbReference type="EnsemblBacteria" id="ADW67565">
        <property type="protein sequence ID" value="ADW67565"/>
        <property type="gene ID" value="AciX9_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0493"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043515_0_0_0"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230059" evidence="1">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="37199" checksum="A90081F0280D6FD3" modified="2011-04-05" version="1">MPTMMKLASLSLLLSSTIASNAHTPKPVPSVPFHVEAEWNVGGAGGWGFLSLDPANHQLYIPRTNRVMVVDTQTGKQTGEIAGMKNVRGIAIDDTGRYGYISDPTDGTAGFLRVFDRKDLKLIASVSTGLVPDTVVFEPATKLVFVFNSRGHSATIVDSKTNEIVATLPLAGRPSTAVGDGAGNIFVTLPAMGEVVRIGAASREVTASWQLAPCTGPNTLAVDPKGHRLFTTCESHKIIAINTGSGAMTPVGDAPAGSGDMGFDEQQSTLFLADATGMLTSFHRDGTGHYASAQQLKTQPGARTMIVNQEEGKVYLVTSKFGQNTGNVSEELQYRPTPVPGTFSILVVGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY68</accession>
    <name>E8WY68_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1643</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1643"/>
    <dbReference type="EnsemblBacteria" id="ADW68695">
        <property type="protein sequence ID" value="ADW68695"/>
        <property type="gene ID" value="AciX9_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1643"/>
    <dbReference type="eggNOG" id="COG5267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023627_0_0_0"/>
    <dbReference type="OMA" id="NGFDITC"/>
    <dbReference type="OrthoDB" id="637794at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="709" mass="72827" checksum="1F2951BEEA71E91F" modified="2011-04-05" version="1">MGLGSAMLLGGCSGSGNSGSTGGGPVLSPTVAVTGGASTRLGGTTQFAATVANTNNLSVTWQVNGTTGGSSANGMITSTGTYTAPATLPSPNTVTISAVSAASASAVGTLSEAVWNPVPVVTAAAATQTGTASTVMIDVKGTSFVSGAQIQVGGASVTTTAVSSTELQASVAATTAASLAVDVWNPDPGAAASTVSQVAISVVKVPVAAASRLLDQATFGPTLADIQHVQTVGLDGYLTEQFATPATVLADVPNPQPATCTNVPANCAQSEWWQAALTGQDQLRERVAFALAEMFVISSNSVNGYTITPYQNLLTKDAFGNFSTVMKDVTLSTGMGAYLNMLNSYKPGNGQIANENYSRENMQLFTIGINELNEDGTATLDGSGNMIPAYTQAQVQAFARAYTGWTYATATGGSPTKYPNGTANFDMPMAAVESAHDVTAKVLLNGTTLPANQTAEQDLDGALANLFAHKNVGPFVCKQLIQHLVASNPSGAYVKRVATVFADNGSGVRGDLKAVVYAILMDPEARAGDTNTAAEGGHLREPVLYLANVMRGLGYSNTDPNGYYATLSNYSGNLSEKPYAAGSVFNFFPPSYVIPGTTVNAPEFSLENTASAVLRLTLANSLVYNGISGFTVDLSATSALGIMASKTGNAATDSGNLVDALGTIFMHGQMPTNMRTAIVNHVMTLTNIPQRVRVATYLVITSSGYKVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA1</accession>
    <name>E8WYA1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1678</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580047.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68728">
        <property type="protein sequence ID" value="ADW68728"/>
        <property type="gene ID" value="AciX9_1678"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1678"/>
    <dbReference type="HOGENOM" id="CLU_2117566_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="116" mass="12104" checksum="A10EFE0D25E00A12" modified="2011-04-05" version="1">MGIFAPIGESLLHVDKSLNLATFNGGILAHAGTYVLMTAPRSSDGQYHYPATGTAGLVNVPIETGLELSQPILPSSGGIAGIFAPRPKTPDGKDIYIVGVFFTPPISKPPSQPTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD0</accession>
    <name>E8WYD0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2813</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581151.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2813"/>
    <dbReference type="EnsemblBacteria" id="ADW69836">
        <property type="protein sequence ID" value="ADW69836"/>
        <property type="gene ID" value="AciX9_2813"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2813"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_0"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="29500" checksum="2A449A6C2A95A668" modified="2011-04-05" version="1">MSLPLLIVPVIIILYLLNSIKILKEYERAVVFQLGRVGKEAAGPGLIFVFAPIQTIVRVSLRQEAMEVPPQDIITRDNVTLKVNAVITLRVVNPIDAVINVSNYIYQTSQFAQTTLRSVLGEVDLDELLAHRDRLNQRIQTIIDGHTAPFGLKVVSVEVKQVDMPENMLRAMAKQAEAERERRAKIIHAEGEFNAAAKLVEAAALMATQPMTLQLRYLQTLTEIGVEKNTTIVFPLPMELMNLLNRTFTEPAKPVANANSEIANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI3</accession>
    <name>E8WYI3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578909.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0509"/>
    <dbReference type="EnsemblBacteria" id="ADW67581">
        <property type="protein sequence ID" value="ADW67581"/>
        <property type="gene ID" value="AciX9_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0509"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233491" evidence="1">
        <location>
            <begin position="28"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="41320" checksum="14D738C8CB80B12B" modified="2011-04-05" version="1">MTNLTRRAALLTSTLVLSACCAATSFAQMFDPQQLRPYKPDVLIKGGIIIVGGGLKGQVELWEKGFQKFHPDATFGNNFTMSSEGAIPALYLLGADVAPAGDDAKVSDYLAFYETKHYFPTEIAVATGHYETRGALWAIQIVVNKDNPLAKLSLKQLDGIFGAARTGGWDGIFYSAKWARPASENIRTWGQLGLTGEWANKPIQTYGYIAPGFKYWMERRLFHNGDKWNENYKEYVEGRQTVPGDPEGKKVDSERMYEELSKDKYGIAWGPILHSKNYPNVKQIDLSENGGPYVALTPDNVKNRTYPLKRDAYIYIDQHPGKPMDDRAKEFMKYILSREGQEDVKNFGFFYPLPQNVIDEQLKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL3</accession>
    <name>E8WYL3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0539</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67611">
        <property type="protein sequence ID" value="ADW67611"/>
        <property type="gene ID" value="AciX9_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0539"/>
    <dbReference type="eggNOG" id="ENOG502ZAI9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070295_0_0_0"/>
    <dbReference type="OMA" id="YWFPTYT"/>
    <dbReference type="OrthoDB" id="1571810at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="37944" checksum="526F6CBCF9022494" modified="2011-04-05" version="1">MVASSQTRPHPKPLGLFASFTFAAALLVLSPLSVRQALALAPVPNPHGPEVMGSQDAEGFGKLDPKPPTGLTTDEIVKKFGARETAFNQALNEYTFRRTVRVETLAEDTNKVDGVYQDVTDIVLSDNGGRSEHVVFAPQNTLERVMMTQSDFDDITHRLPFILTTKDLPQYDLTYMGRQHVDDLDTYVFEAAPKTLVKGQRYFQGRIWVDQKDLQIVLINGKTVPQDMRRGHEDLSPPYTTYYSEVDGGYWFPVYTHAEGNLHFAAANGALAQDVHIRYTVKYADYKRFHAKSRIIYNGETLPAADPSKPDTPEKTNTEPTAQPAADPNAPNLKHTKPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ6</accession>
    <name>E8WYQ6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="5" type="ordered locus">AciX9_1693</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580061.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1693"/>
    <dbReference type="EnsemblBacteria" id="ADW68742">
        <property type="protein sequence ID" value="ADW68742"/>
        <property type="gene ID" value="AciX9_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1693"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_0"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="20283" checksum="2EA32695C21C4098" modified="2011-04-05" version="1">MPRQASITIPAQQPKPVVQEKDRDPIAAGKRDASFNRSASFNYFLTDKYEAGVALRGTEVKSIREGKANLKDAYGLLKDGECFLLNAHIGPFSHGNAMNHEALRTRKLLLHKLEIRKLEAATRQKGFTLIPVRLYFRHGRVKCELALAKGKQEWDKRATERKREADSEAKSAIARSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYX0</accession>
    <name>E8WYX0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1758</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580125.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1758"/>
    <dbReference type="EnsemblBacteria" id="ADW68806">
        <property type="protein sequence ID" value="ADW68806"/>
        <property type="gene ID" value="AciX9_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1758"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_0"/>
    <dbReference type="OMA" id="HFSNKEV"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21767" checksum="E89DE4D5C66DC590" modified="2011-04-05" version="1">MATISTTREHLLEVGLRQLRTTGYTATGVKEVLDLAHVPKGSFYHYFSSKEAFVSELFDRYAKGEGERAQRVLGDTSIAPLERLRTYFEELISIYGEPGEGAGCLVGAMSLEIADHIPKLQAQLQSMYAGWQHGIADVLRQAIKRGDLAKSTKPDALAEFILNSYEGALVRMKAEQDSSPLRNFQHFIFDIVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ73</accession>
    <name>E8WZ73_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0604</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0604"/>
    <dbReference type="EnsemblBacteria" id="ADW67675">
        <property type="protein sequence ID" value="ADW67675"/>
        <property type="gene ID" value="AciX9_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0604"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015664_0_0_0"/>
    <dbReference type="OMA" id="GMQHAVE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="742" mass="79610" checksum="2F3783F8EB2C0A8A" modified="2011-04-05" version="1">MEDDLTVAFVNVSGDGAAATPAPAPVTLKTWGRFELLARVGEGGFGEVYRAWDPDLQREVALKLLLPSAMNPNLEYEEVLREARAMAAVRHLNVVPIYGIDRQDGRVGFWTDFVHGVTLAALLEQQGPFGYREAALIGLDVAHALSAVHKSGLLHRDIKAENVMREEGGRILLMDFGLSSLAQQAHGLAGTPAYMAPELFTGAVATVGTDLYAVGVLLFYLVAGKHPVPFLGFQQEQLDEAQRQRLFLPDLRPDLPESFLRVVNVASDPDPKRRFGTAGQLSAALSEVLGGTRVVEADQAAAAVAVPVKPMRRWLWFGLAGVLVLLLVAGLVWRERVTNGVTAGAAGVSASNYETYSKAQDLVVHSYLNRNLAAAIDGFNQVLKNDPGFALAEAGLGRAYFLQYHLTRNQESLDKAQAATKRALELDANCAPAYVTLARISTTGGNTSLALQQVAKALELEPLNAEAYAAKADVFAAERRDADAKEALSHAVDLAPDDWRFPVLLGNYEFAAGNLQEAVTLYKRGAELAPDNVIAFYNLGDTQEKLGQLGEAQASFEKALKIEPRFAIYSALGGLLSLEGKHAEAIRMGQKAVELNPGDYNTRQNLAEAYLWSPGGREQAMATYREAIGLAEHARLTSPRDPALLISLAYAYALTGDKGKSLPLIRQSLALSPDDPDVSLRAGVTYEVLGQRAEALRLVAKALAGSYSPVWVEHNPELAGLRSDPGFGAALAKAKSKGAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD5</accession>
    <name>E8WZD5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ordered locus">AciX9_1775</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1775"/>
    <dbReference type="EnsemblBacteria" id="ADW68823">
        <property type="protein sequence ID" value="ADW68823"/>
        <property type="gene ID" value="AciX9_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1775"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_0"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="194"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="301" mass="30909" checksum="83AFB0518DDCE373" modified="2011-04-05" version="1">MRGLRLVGSVQSDKLLGMSEIELEIVRPAAMMPGVKVAVLGAGKMGGILLQAFLKNNLLAPEQIVATVQHADRALALSAQTGVEVTTDNLAAATWADVILLGVKPIQVPGLIETIKGGLTAEKMIVSFAASVKTTAIEAAAGLELAVIRAMPNTPSMLAAGVTALCGGRFASAEQMSVAQRIFATVGRTVVVAEKHMDAVTGLSGSGPAFIYIIIEALAEAGVNVGLPRDVATLLAAQTTLGSAKMVLETGYHPALLKDQVTTPAGCTVDGILELEEGGLRVTLIKAVKRATARAKELAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU2</accession>
    <name>E8WZU2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579081.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0683"/>
    <dbReference type="EnsemblBacteria" id="ADW67753">
        <property type="protein sequence ID" value="ADW67753"/>
        <property type="gene ID" value="AciX9_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0683"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_0"/>
    <dbReference type="OMA" id="MNTHADR"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="19682" checksum="154226F77519E59E" modified="2011-04-05" version="1">MRKLVLSLVVAGGVAAGLCGMKAYGFGGVDSPLQPGATAPNFSLPSQTDSMVSLKDYKGKYVVLYFYPKDQTTGCTIEAHNFERDTAKYAALNAVVLGVSLDTVESHKTFCSKDGLNFKLLADPEHKVIDAYGVPVATMGTNQYAKRDTFLIGPDGKVLKFWEVKAIQGHSDEVLAAIQDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX2</accession>
    <name>E8WZX2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0713</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579109.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0713"/>
    <dbReference type="EnsemblBacteria" id="ADW67783">
        <property type="protein sequence ID" value="ADW67783"/>
        <property type="gene ID" value="AciX9_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0713"/>
    <dbReference type="eggNOG" id="ENOG5033BRP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209713_0_0_0"/>
    <dbReference type="OMA" id="WEMIVEA"/>
    <dbReference type="OrthoDB" id="2082491at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="7250" checksum="A3EDFD894DEA458E" modified="2011-04-05" version="1">MTEELQHLIESARTRPFPEEEREAQRRSFAYGNTKIENNLITREMVAEQDERLKREMQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X003</accession>
    <name>E8X003_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1853</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580218.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1853"/>
    <dbReference type="EnsemblBacteria" id="ADW68899">
        <property type="protein sequence ID" value="ADW68899"/>
        <property type="gene ID" value="AciX9_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1853"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333674_0_0_0"/>
    <dbReference type="OMA" id="QLHVRGD"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230123" evidence="1">
        <location>
            <begin position="26"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="905" mass="97184" checksum="3F7C2B32122BDA6C" modified="2011-04-05" version="1">MRIISRNSSISLIALLSFAATPIFASLLAPSAAAQAATANSGTISGTVTDPSGAAVQGASVVLTNSNSGYTRTVTTGPDGAYQFANIPFNPYRVVIVMPGFSTSDNVLRIHTSVPIVLKTALTVASAGEQVTVEAGGELLDNDPTAHTDIEREVFTKLPIESVSSGLSSLITLAAPGVSADSNGLIHGLGDHAENAFYEDGQPMTDQQSKVFSNQLPISAIQSLEIIAGAPPAEYGEKTSLVATISTRSGQGLTKPRGNITASYGAFGSSTGSADLSFGGARYGNFTAVDLLQSGRFLDPAEFSVFHDKGNQENVFDRVDFQPTKQDSFHLNGNYTRSWFQTPNSYDNLNLTDQFGTPIANTDQRSKIGTLNIAPSLTHIINDQSIVTGILWVRRDHYNYYPSKNPFSDLGPIQQETISQDRDLTNSGARIDYNYVKGVNNIKIGGTYQQTLLNEKFNLGIVSPTLNSPCVDVTGAPVSGATSPFQCIAFGELPNPAFNPLLGCYDLTRPTPGAADGCATGAAAQSFRFQGHTDVKLLSFYGQDAITKGNFNISFGLRGDLYNGLAISKQVEPRAGIAYHVKPTSTILRVSYARSMETPFNENLILSSTGCNSPVISALVPCVPAAFNPGFRNEFHAGFEQAAGKHLVITADYLWKYTHDGYDFSVLGATPITFPIEWHNSKISGFDLRANVPDYHGLTAFVVMSSVAARFFPPQIGGLGATQTGGSPFRIDHDEKFNETTHIQYQYKKQGPFMSFNWRYDSGEVAGGVPFATTTTTPVDLTGLTSDEQQQAGLYCGNVKATLGHPLTTCAPGLYHSSLVSIPAPGTENDDHNPPRIAPRNLFDLSIGQDNLFPKLMHSDDHRFSATLTVINLANKYALYNFLSTFSGTHYVTPRALTAEIGYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X028</accession>
    <name>E8X028_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GWxTD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1878</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580243.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1878"/>
    <dbReference type="EnsemblBacteria" id="ADW68924">
        <property type="protein sequence ID" value="ADW68924"/>
        <property type="gene ID" value="AciX9_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1878"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445353_0_0_0"/>
    <dbReference type="OMA" id="FWMQVYN"/>
    <dbReference type="OrthoDB" id="500996at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030959">
        <property type="entry name" value="GWxTD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20094">
        <property type="entry name" value="GWxTD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04514">
        <property type="entry name" value="GWxTD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234219" description="GWxTD_dom domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="GWxTD_dom" evidence="3">
        <location>
            <begin position="81"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="577" mass="64788" checksum="47C97452DDC0AB74" modified="2011-04-05" version="1">MNFPLVRTVRLVFGVAALSMMLAGGQTLHAQNPGQDGVTKVPVQKDKPDPTERPRTDQETRSAQKGMKQELKGSYKTWVDQDVRWIITDQELSAFKHLSNDEERDQFIENFWLRRNPNPDSPDNEYREEHYARIAYANEHFAAGKAGWRTDRGHIYIAYGKPDNIDSHPSGGNYERPMEEGGGSTSTFPFEIWHYRYIEGIGDNIDVEFVDTCMCGDYHMTLDRSEKDALKHTPGAGQTLYEQMGQAKQADRFSGGGLEQLGTGPMSQQNASKQFDRLDQFAKLGAAPVIKFKDLESYMVSSKILTGPPFLFDVRTDYVKVTNDTVLVPLTLQIHNKDITFNTKDGVSTGTVNILGRVSNLNHRVLQTFEEPVAVQVPSELLGQTQTQSSVYWKAIPLRPGLYKVDIVIKDVNNPDHIGRWQRSVNVPKYIDDELSHSSLILADRMERVPSKEIGAGNFVIGNTRIRPRVPTGVAVPIAFHRNQNLNFWMQVYNLGIGANKQNGATIEYQIRDLATNKDVLDTSEQTDKLNPNADQVTLEKSLPLASLTPGKYEVSIKVNDGVRKQQIAETASFTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X042</accession>
    <name>E8X042_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1892</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580257.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1892"/>
    <dbReference type="EnsemblBacteria" id="ADW68938">
        <property type="protein sequence ID" value="ADW68938"/>
        <property type="gene ID" value="AciX9_1892"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1892"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_10_2_0"/>
    <dbReference type="OMA" id="KLGNRWR"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9510" checksum="E9BA561530C63ECA" modified="2011-04-05" version="1">MASAVHTMLREVMDIRQASDYLGISGDTLYRYASEGLIPAFKLGNRWRFKRSLLDAWMVEKSGVREPGPVSVMPKEKKPVGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X051</accession>
    <name>E8X051_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ordered locus">AciX9_1901</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580266.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1901"/>
    <dbReference type="EnsemblBacteria" id="ADW68947">
        <property type="protein sequence ID" value="ADW68947"/>
        <property type="gene ID" value="AciX9_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1901"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_0"/>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="411" mass="44368" checksum="A1CDF37B5379181C" modified="2011-04-05" version="1">MRLQSIQAAEKKLVLNTYERYPILFTSGHGVFLTDENGVDYLDLLSGIGVSALGYGHPTIERAIAEQSKKLLHTSNLFFTEHTADLALRLTEISGLDRVFFCNSGTEAWEAALKIARAHSDKSGTGKKFLALEHSFHGRTIGSVATTHKLAYRTPFAPVMPDVEFVKFNDVEDLRAKFNNEVCGILIEAIQGEGGIHPVTQEFFAAARELADSTGALLIADEIQCGFGRTGKWFGYQHFGILPDVVTLAKPLAGGLPIGAMLCTERVSQSITPGMHGTTFGGGPLATGVAIAVIDEIKHSNLLAHIEEVGAYFKSALQALAKKHPQIVEVRGKGLMIGAELDSPDLAKSVASEMLARHIIINRTSEVVLRFLPPYILEKSHVDQAIAALDAILTQHAEQSQPIASGEHANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X062</accession>
    <name>E8X062_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3022</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581357.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3022"/>
    <dbReference type="EnsemblBacteria" id="ADW70043">
        <property type="protein sequence ID" value="ADW70043"/>
        <property type="gene ID" value="AciX9_3022"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3022"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069618_0_0_0"/>
    <dbReference type="OMA" id="MAVAIMF"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="285" mass="30907" checksum="9EAD8A5BC88693EA" modified="2011-04-05" version="1">MSTALETRPATQPAGSNLAMYARAFAGLYLRDLYVLRRELFPFAVRVCMNPLLFLFVFTYIMPHMTNGAAMNPTARLAGSSFSTVLLPGLMAVAIMFSGIAAVALPLAQEFGITREIDDRVMCPLPVAFVAIEKIVFSAMQSIIAAAIVYPLARYIPATPAVAHVTSWPFLILVLILASLVSGALGLTIGTSVKPQQIGLIFGVVVVPITFLGCVYYPWAALGPIRWLQIGVLFNPIVYMSEGLRAALTPSLNHMPEPLILGMLCIFLALLTWLGMKGFMRRVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J3</accession>
    <name>E8X0J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0788</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0788"/>
    <dbReference type="EnsemblBacteria" id="ADW67857">
        <property type="protein sequence ID" value="ADW67857"/>
        <property type="gene ID" value="AciX9_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0788"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_2_0"/>
    <dbReference type="OMA" id="GNPANMC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17689" checksum="D06F992CC46B8A4B" modified="2011-04-05" version="1">MSMSLADEIKQAKPFASAKEELWLNLLRTTGIISHEMEQNLRPRGLSPTQYNVLRILRGAGAEGLCQYEIRDRLVAQVPDVPRILERMEKAGWIKRNRGEADRRMVIASATEEGLRLVGDLDQPMVQWMNGLFGELEEMELEQLSELLGRARARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N4</accession>
    <name>E8X0N4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580304.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1939"/>
    <dbReference type="EnsemblBacteria" id="ADW68985">
        <property type="protein sequence ID" value="ADW68985"/>
        <property type="gene ID" value="AciX9_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1939"/>
    <dbReference type="HOGENOM" id="CLU_2464706_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="8645" checksum="B6175A99A669D6B3" modified="2011-04-05" version="1">MSISIPSFAVNPPDYAAGQPTDQAAPTAKPSVSQQMHTLATSGQSAQQIATSLGLPTSEVNAALGITTSPSGTATAVVAAAARLSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N5</accession>
    <name>E8X0N5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580305.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68986">
        <property type="protein sequence ID" value="ADW68986"/>
        <property type="gene ID" value="AciX9_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1940"/>
    <dbReference type="HOGENOM" id="CLU_1862355_0_0_0"/>
    <dbReference type="OMA" id="ETHDIGM"/>
    <dbReference type="OrthoDB" id="676187at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="14719" checksum="239C3C62F51FA598" modified="2011-04-05" version="1">MQANKLRNPYPARRESYIYIGLCIAAVIGLAAFSLLPEQAKQVLHTAGRLHPYGHLAAFAVIGYLTGRISKTPGQRILFFLGSLAFGTGIEFCEHFIYGAVLETHDIGMDALGVLLGTGIALFLSKPVSGSEQTSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R9</accession>
    <name>E8X0R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1974</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580339.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1974"/>
    <dbReference type="EnsemblBacteria" id="ADW69020">
        <property type="protein sequence ID" value="ADW69020"/>
        <property type="gene ID" value="AciX9_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1974"/>
    <dbReference type="eggNOG" id="ENOG50336A7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265453_0_0_0"/>
    <dbReference type="OMA" id="ECRGMTN"/>
    <dbReference type="OrthoDB" id="1942738at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="218" mass="23777" checksum="825208C59665B0AA" modified="2011-04-05" version="1">MLNTITLNGQTVSIVASPTCIALRSIELSGSDSVAIVTSPFSGQTQAQQWPGADWWSGTATLPPLTQDQADEWLSFLMECRGMTNPFLMGDPLKSSPRGSVTSASVPVVDMSVTTLNQVGNQVLYTKGWLPNAFSLLLPGDYLQIGYRLHRCLDRVNSDANGKASFSIFPSLRDLPADGQPIILNNPQGLFRRGSNKMTWSSDYTGLTNLSFPLIEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H7</accession>
    <name>E8X1H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581524.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3201"/>
    <dbReference type="EnsemblBacteria" id="ADW70212">
        <property type="protein sequence ID" value="ADW70212"/>
        <property type="gene ID" value="AciX9_3201"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3201"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023626_0_0_0"/>
    <dbReference type="OMA" id="DDWVYRD"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230165" evidence="2">
        <location>
            <begin position="21"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="644" mass="69330" checksum="7078D79FB0916DE9" modified="2011-04-05" version="1">MSRYSLPVLTALLAGQMLVAQDVPAAPQVPQGKVLFSTDHPPNEQQPAISSSSGIPLPGPPDSLPKVAVTDLERSGVVIDSYDLDLHLIPADAREEMHATLVIRNSSATSISRIPLQVSSTFRWQGVSLVGTGLKPVAFTQSPIATDADHTGYAQEAIVTLPEPLAPGATVTLSVFYLGEVRQSAARLEILGTPTDRADHAEWDEIAQTDDDSATALRGFGNVIWYPVAAPTAVLGDGNKLFEVIGHQRVQDLTAKIRLNLTVEYVGDPPVGVVFDGELQPLAATVDDKDELVGNAHGLATAEFPVRPIGFRIPSLFLTAQQPSVTDGQMLSVITPHTETIQPYAEAAAKVQPMLVDWFGATPIEPLILLDHPGEPYEDHALVVGQLAGDAQADDIAPTLVGGLSHAWFHSSHPWISEGLAQFMSLLWIERTAGRQAAMGALAHEANLIALSEPDFSLAVPGGGEALTEASSEVYYRSKAAAVWWQLRDILGEDVLRQGLAAYRKSVALNASFDSDPKAMQKTLEKVSHRELGWFFDDWVYRDRGLPDLAVVAVNPRLLPARPGKNSGYLVAVEVRNDGDAVAEVPVTVHSGRLTSTERLRIPGHGTASTRILFEDTPETLQVNDGSTPELRTSVHNRDIQITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P4</accession>
    <name>E8X1P4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0895</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0895"/>
    <dbReference type="EnsemblBacteria" id="ADW67963">
        <property type="protein sequence ID" value="ADW67963"/>
        <property type="gene ID" value="AciX9_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0895"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_0"/>
    <dbReference type="OMA" id="ANSWNEP"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="35757" checksum="D8DFA74F81F6D7D4" modified="2011-04-05" version="1">MNVWMKSGFLLGLGILGFTGVGASGQMHRHERDRVEATESQNCFDASDPQEIRLWEGRAPGAAGDDPCRDIPYLKVFRAESGSRQPRPVILVVGGGGYDRLTDTKEQAPVAEYFSRTLGVDAFVLYYRLVQKDGTYRYPVPMWDGQRAIKLVRARAAQLGVDPGRVAMFGFSAGGHLASTLALHSASDFDLPVHDAVDGQKGRPDLLGLGYPVISMDPATVPPSGSYKNLLRGFDGGQLRHLQDYLSGEKNVTPHTPPVFLFESMDDARISPQNSVLFVAALRAAGIAVDAHLFAHGEHGAGLAEGIPEESAWPGLFRDWLVGQRFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P8</accession>
    <name>E8X1P8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0899</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579291.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67967">
        <property type="protein sequence ID" value="ADW67967"/>
        <property type="gene ID" value="AciX9_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0899"/>
    <dbReference type="eggNOG" id="ENOG5032Z9K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871339_0_0_0"/>
    <dbReference type="OMA" id="SNAPGFN"/>
    <dbReference type="OrthoDB" id="1847301at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233587" evidence="2">
        <location>
            <begin position="33"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="36039" checksum="DA545D79DC9B3981" modified="2011-04-05" version="1">MLNDSLILRPSAFVCRTAAIAALACASTLGFAQQSVSDVDTTKAATAPVVLPAVHPMDFSGLDGVSYSSSTEPVGGVDVAETATLDIKGLDALQPPPRRRYGNRRYNDSSHNPDGSNKYAFIAGVGVTIPAGNLHKYDTESWGFQVGGGRNFNKHFSVLAQFDYDHFGLQGTTLTNQNTLYGTAGDGLDGNSHIWSFTVNPTYNIAVRETLGAYVVGGVGFYHKVTNFTLPETGEYFDPYYGPVEYTANEVIDHYTSNAPGFNGGFGLTYKPSRFAGERFYAEARYVYMINSQKQGITVANANSAFGAAYTGSNFYPANSNRTSYIPIKVGVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U5</accession>
    <name>E8X1U5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2061</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580423.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2061"/>
    <dbReference type="EnsemblBacteria" id="ADW69106">
        <property type="protein sequence ID" value="ADW69106"/>
        <property type="gene ID" value="AciX9_2061"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2061"/>
    <dbReference type="HOGENOM" id="CLU_2806442_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7311" checksum="33F43E01218E2503" modified="2011-04-05" version="1">MRMIMLDGRAINPHAIVYIENYRGNSPDEQSMVNLIGGGKIICSMKAEAARKFINAAMDEAEAITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X214</accession>
    <name>E8X214_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3246</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581569.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3246"/>
    <dbReference type="EnsemblBacteria" id="ADW70257">
        <property type="protein sequence ID" value="ADW70257"/>
        <property type="gene ID" value="AciX9_3246"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3246"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_2_0"/>
    <dbReference type="OMA" id="GTDAKQF"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233598" evidence="2">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="217"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="50322" checksum="2C585E2CB1FD56B0" modified="2011-04-05" version="1">MKLQLLLRSLCCASISAAAFAQTPQAGMLSADASAAEMNGFLRDLVRIDTRNPPGDESKVANYIAKVFQQQGIPYELLEPVPGRASLVARLKGDGSKKPVLLLAHEDVVPVDRAHWTVEPFGAETRDGVLYGRGASDDKSPLAAHLETMLQLHRSGKTLTRDVIFLAEASEEQDSAAGMHTIVERYWDKVACEFAINEGGAAEVKDGKVAYLGVATGEKMPRGVRLVAKGKSGHASVPVLDNAVTHLAQAVARLGTWETPVRLNETTTEFFSRLAGISTPADAKLFRSLNDPKTQMTLHKDMPQFYSMLHTSVVPTVLKAGFKSNVIPSEAEAQIDIRALPDENMPAFYAQMAKIIDDPSITIVPPDLTDAMPAAPASSLRTPMFEAFDAAQKDVLPEAITIPVMSTGATDSAFLRAKGVNAYGIRVPRTFAENEGVHGNNERIQLKYVAVYQRFVQAAVEKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X249</accession>
    <name>E8X249_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PepSY-associated TM helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581604.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3281"/>
    <dbReference type="EnsemblBacteria" id="ADW70292">
        <property type="protein sequence ID" value="ADW70292"/>
        <property type="gene ID" value="AciX9_3281"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3281"/>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_4_2_0"/>
    <dbReference type="OMA" id="HRGRFFG"/>
    <dbReference type="OrthoDB" id="1656356at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="374" mass="42112" checksum="C6C8E1F8FA64DEE8" modified="2011-04-05" version="1">MPFVQTFLHHPRKLFLRWALFQVHLWAGVLLSLYVIVIALTGSILVFRSEIVRAQLPSTLTSYNPSQTASIAQVIAAVQRTYPAAHIADLTLPSSISPAFVIAAQNPDHHSFYLLADPTTATLYPRHRTWIDWTYDLHVYLLLGTAHGMQVNGIGAAILMLLCITGLVLWWPGLKLWTRGLRISLRHNWRRINFDAHSAIGFWTLLLVSWWAFSGIYFAWYKQVAAAVAIVSPIRGMAAPIAPPRPTSNQHASLEAILQAIHQAAPQGHLYSLSDPALTTPTVYALVDLRAPGDFSHRDIISLSTRDARILTDWHYGQNHTLGDWVLWAMHPIHFGTVWGTPIKILWSLLGVSLAVLTLTGLLMYWNRYLRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X257</accession>
    <name>E8X257_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3289</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70300">
        <property type="protein sequence ID" value="ADW70300"/>
        <property type="gene ID" value="AciX9_3289"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3289"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_3_1_0"/>
    <dbReference type="OMA" id="AKYHRIA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="33399" checksum="4473AFC3EDB84D28" modified="2011-04-05" version="1">MQIHSVGIDLGKTTFHLVALSAAGKVLLRKKFTQKQLITFTANMQTSLIGMEACSGAHFLGRALRAQGHDVKLIPAQFVKPFVKSNKNDFLDAEAIAEAVDRQNMRFVPIKTDDQLDLQAMHRVRDRLVARRTSVINQLRAFLLERGMVFAKTPIKLRQAMPEILENAESNLTPRMRNLVSLLWSEWKDLQQQIVAMNEEVEQIASSDPACQRLRQIPGIGPLVATAIVAAIGNGAAFHKGREFSAWLGLVPRQHSTGGKARLFGISKRGNRYLRKLLVHGARSAVLIVKRDAFPVWALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X274</accession>
    <name>E8X274_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cna B domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3306</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581629.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3306"/>
    <dbReference type="EnsemblBacteria" id="ADW70317">
        <property type="protein sequence ID" value="ADW70317"/>
        <property type="gene ID" value="AciX9_3306"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3306"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="GLDNNDQ"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234103" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="496"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1299" mass="139733" checksum="F5810F7C5FFCF759" modified="2011-04-05" version="1">MVHKQRTYAVLLSMFLFCFVQGLLSQQTTTSVRGIVTDATGAIIPGAAVDLRDKTAVVHKDIVSDSKGEYSFVQLVPGEYTIEVESPGMGKQAKVVQLLVAQPATVNFALTVSNSTVVEVQATEAMLNTTDATIGNAVDSETVAALPMEGRNVPDLLSLQPGVLYLGHNLTQANEDSRSGVVSGARSDQGNVTLDGLDNNDQVTGLAFNGVLRSTLDSVDEFRVVTTGDNAESGRTSGAQVNVVTKTGSNRFIGSLYEYNRNTDMAANDWFNKQSQFLEGIPNRTGKLIRNTFGAAVGGPVLKNRLFFFGNYESQRTAENQQVTGTVPTAAYRNGVLQYTTANANATNVVGQVGTGTYLAQLTPSQFAQLDPNCTTSCPWGHGEDPNILALAKQFPLPNASGGDGYNTSGFTWSAPNPTILNTGILKLDYVLNDKHRMFVRGNMQADRTLSPALFPTSGAAGFFSTAPQAPSDIHSDSTKGFGLGETWVINNSLINNVRFGYTRQSYSDQGPGKTAYTTPTAIGLPYSTARTQIITVPVYNAIDDLTWTHHSHNFQFGANFRLIKDSLLTDNASYSSATSSSGETFDAISNTGQTLDPSSPEGIAAGFGAVQTSFGSAYSSLAMGTAGVVASESIAYQYHYNGDGTSTLLPNGALVPRHFKANEFEWYFQDQWRITSKFTLTYGLRHTILQTPYEENGQQVSPTVSLHDFFDTRVAQAAKGIVDQPNFTFAPSGQANNAKSFYPMSWKNFSPRLGFAYALDSKTSVRSGFGLYFDHFGEGMVRNYSELGSYGLGGKESTPAGYFSPDTAPRFTSITALPTYSTAILPTSYLPTPSATLKYPYAPPANGQAGGWLMDDHISTPYAMTMNLDVQRQLPSNFTVEAAYVGRFGRHLIVQQDHAMPLDLVDPQSGMDYFTAASLLETQAYSGVATGAVQKIPYWENLFPDAAGAAGSPQASIPCPKTVCQAGNTSTQNIYNQYKAQPLNATDDLNLMDTLCSPGCGGQLFRYYTGAFSSMYADSTIGTSSYSAGQLIVRHPMQHGLQMDFSYTLSKAIDIGSDAERTCTSCTSIGTTADASTGVLINSFKPRLNRSVADFDTTHIITTDAVYKLPFGRGGAFVNHPSGWVNSIIGGWQLNGLGRWTSGLPFTLTISGGWMTAWPKTAYVIPTKPLGNLAPHKSRINGVPNAFPNPTGLVAGITGLASNPSPLRYPLPGEVGARNSFRGDGYFGVDSGLMKTWKLTDSQSLKFDWEVFNVSNSVRFDTNTVTSLKNTVGSGNLGAYTHTLTQPRVQQISLRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X285</accession>
    <name>E8X285_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secretion/fimbrial assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579341.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0950"/>
    <dbReference type="EnsemblBacteria" id="ADW68017">
        <property type="protein sequence ID" value="ADW68017"/>
        <property type="gene ID" value="AciX9_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0950"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876502_0_0_0"/>
    <dbReference type="OMA" id="YAMANLM"/>
    <dbReference type="OrthoDB" id="1965052at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="31827" checksum="22869B2275E515A3" modified="2011-04-05" version="1">MNRPLNKTKAQGEDGFLLVALVVAIFLILLALSVAAPRVARQLQREREVESAHRANQYVRAIRLYYKKFGNYPASMEALKKSNNIRFLRQEYVDPLTGKSDWRLIRVGTNKTKVKGFFGEDLPGLAGGLGSAANLGSAASSGSGFGSGSAFGSSSGSGSGASGLGGTSGTTGITSGSGTTTGTGTGTGTGSSSGSSFGSNSGFGSASSQDASSLGGSSGPFMGVGSAKTGEAILVVNEQTNYEDWEFLYDPRIEQMYAKSSLLGGVSSGSSSGSLGSLGGSSSAGQGTTGSPTSPTSGFGSPTTPTNPTSPTSPTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A8</accession>
    <name>E8X2A8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0973</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579364.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0973"/>
    <dbReference type="EnsemblBacteria" id="ADW68040">
        <property type="protein sequence ID" value="ADW68040"/>
        <property type="gene ID" value="AciX9_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0973"/>
    <dbReference type="eggNOG" id="COG1543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_0"/>
    <dbReference type="OMA" id="CAYYEGL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="15"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="469"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="586" mass="66344" checksum="D2291A571FDDBDD2" modified="2011-04-05" version="1">MNQSEKPRPEGFLTLTLHAHLPYVVNHGTWPHGLEWLHEAAAETYLPLLRVLGRLEKDGIGLHCNLVITPVLMEQLAHPVFLAEFPNYLTRKIVAAREDEAFFTQSGESHYAETARFWHRFFTQALDDFNTLDGSILGAFRRFHEKGLIEIITCCATHGYLPLLGTDESVRAQIRTAVTTHKRHIGEHPKGIWVPECGYRPAGYWNYPVNNQDGSHIAGGFTRIGVEQALSESDIKFFFVDTHLVEESAQIDSPYSGGNRHLATHPRITPQDPRSLYQPYYVTPYNNEATQNTVTVFPRDPRTGVQVWSGESGYPGDSNYLDFHKKRWPGGHRYWRVTGPQVDMGNKEPYYPQDAAARIQSHASHFVHLIHEALAEARKGSAPDAPPPILCAPFDAELFGHWWFEGPQWLEAVARTLHDYPTGLELTTCSTYLDQYPRAGSIAMHEGSWGAEGTNEVWLNPETSWTYTHIYPAELYVRQVCTGSQWRSSELATRIVQQLCRELLLLESSDWQFLITTGAARDYAELRFMTHNDQYLELKGIWEAYSADGQLNEHQSGRLAAIEQRDSIFADLDPAFWAAGASEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A9</accession>
    <name>E8X2A9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0974</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0974"/>
    <dbReference type="EnsemblBacteria" id="ADW68041">
        <property type="protein sequence ID" value="ADW68041"/>
        <property type="gene ID" value="AciX9_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0974"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760604_0_0_0"/>
    <dbReference type="OMA" id="STHAGGN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230589" evidence="2">
        <location>
            <begin position="17"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="3">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="37881" checksum="C465FCF8F9AFE189" modified="2011-04-05" version="1">MSNLTCRTLVLATALAAGLSGCKSKPTASAPDDAALSSAINAQLIADTAINNQPIQGSVQDGVATLTGSVANDAQKTIASRDASSIQGVRSVVNNLQVGAPYAGQPAAPAPTATVVAPPPPPPARLAESRKPTAMVPQLKPQPRQSAPVQRDFPQDVPMPPVASNQPAPVFTAPPPPPPPPRPTFRDVTVPSATTLPVRITQTLDSATTQAGETFSGTLAADVMIEDQVVLPAGTAVSGRVDAVQEAAHFKGNSLLTVSLTSVRPRGASLPVTSEPYSVEGKGRGKNTAEKTGGGAAVGAILGGIFGGGKGAAIGAVTGGGLGAGSNAITKGQQVQIPSETVVRFHTDSPITVHVRVGGPRGNEDVDPSLQHRPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B6</accession>
    <name>E8X2B6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M61 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0981</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579372.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0981"/>
    <dbReference type="EnsemblBacteria" id="ADW68048">
        <property type="protein sequence ID" value="ADW68048"/>
        <property type="gene ID" value="AciX9_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0981"/>
    <dbReference type="eggNOG" id="COG3975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435415_0_0_0"/>
    <dbReference type="OMA" id="FRTHAIA"/>
    <dbReference type="OrthoDB" id="679125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024191">
        <property type="entry name" value="Peptidase_M61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016493">
        <property type="entry name" value="Glycyl_aminpptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233604" evidence="1">
        <location>
            <begin position="21"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="539"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="656" mass="71852" checksum="4441BCE4D235ECAF" modified="2011-04-05" version="1">MQKLVPCLLAATLFTSAACAQKTPIRITADLTEAPRKLYHAEIDLPVKAGAITLITPQWIPGNHAPTGPASQIVGVIFTAAGKDGQIKQLPWRRDDVNLYEFHLEIPAGVTSLHAHLDAIVDSRVSRQMACLEWERLMLYPAHIPVKDIAIEPSVTVPAGWGIGTALTPVGAPTPPPPTTGIMESAHTPLPGSTTTHYAPTDVEQLLDSPVIAGKYFHEFPLAPEVSPKHYIDVVSDKPEDSNLRPELLAEISNLVREATTAYASSHYNAYHFLLTLSDVAGGEGLEHGQSSDNGIGEKGFSDESHQAVEADLLAHEFTHSWDGKYRRPVELYQKDFATPQQGQLLWVYEGMTQYMGNVLAARSGLRNQEQYRDFLAMSASSLDLESGRNWRSTEDTSIASSIDRHPTLWGNWERGQAYYQEGELMWLDADTLIREKTGGKKSLTDLQRIFLGKGGNTGPLIVTYDRKELIADLNQVLPYDWATFLHERIDLPTPHTDLAGIERGGYKLVYTDKPNASERNAARVYPQYFGGADAWASLGLRAGTSGTISDVRYDGPADKAMLSPGMKIIAVNGQAYSGDAVRQALDDTKGNDKPIRLILQQESAISTAEISYHEGQKYPTLQRIDGTPALMDEITKPLSPATVLPAPKAGKKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C2</accession>
    <name>E8X2C2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0987</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0987"/>
    <dbReference type="EnsemblBacteria" id="ADW68054">
        <property type="protein sequence ID" value="ADW68054"/>
        <property type="gene ID" value="AciX9_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0987"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_0"/>
    <dbReference type="OMA" id="APHIINF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="397" mass="41745" checksum="A9DCBC3FE4B62FF0" modified="2011-04-05" version="1">MDANATTPLLPEVFDAMRPYLLEHFGNASSIHQPGQYARAAVDHAREQMAGLLRCRASEIVFTSGGTESDNLALFGTLGFELGAGQHLITSTIEHHAVLHAAEALEKRGVSVTFLPCTSAGLVEPEALRSALRPETRLVSVMLANNETGSGQPVAELAGIAKAYSKDILVHTDGVQAAGKMAIDLSAKGPLKDVDLLSISGHKMYAPQGTGVLFTRRNVRLAPLFHGGTHERQRRAGTENVAGIVALGKAAEIAAGWLSDGAGPAELAGLRDRFEQTLLREIAEMGVNGAGTERTPNTANLYFDHVEAEALVIALDLKGLSVSGGSACQSGATEPSHVLTAMGLGPARARASVRFSMSRLTTAEDVDLALALVPEAVGRLRSLSPTWKARERGLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M7</accession>
    <name>E8X2M7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3313</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581636.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3313"/>
    <dbReference type="EnsemblBacteria" id="ADW70324">
        <property type="protein sequence ID" value="ADW70324"/>
        <property type="gene ID" value="AciX9_3313"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3313"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="VWGWDFG"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="233" mass="25955" checksum="08366377E65D35B7" modified="2011-04-05" version="1">MPGSQSERILVVEDERKISEAVTAGLKSAGYEVLAARTVEDGLFLLHSQHPDMIVLDLGLPGMSGMEMLRQLRAMGIMIPVLILTSNNSLDDRVAALDLGADDFLLKPFSTAELNARMRAISRRGRPTQVAQLSVADLEINLETRTVVRGGMQLELTAREFDLIVYFVGNRGRTVSREMLARDVWHETSRFTPIDNVIDVQITRLRRKLDDPFPQKLLRTVRGVGFILGEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q2</accession>
    <name>E8X2Q2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3341</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581661.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70349">
        <property type="protein sequence ID" value="ADW70349"/>
        <property type="gene ID" value="AciX9_3341"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3341"/>
    <dbReference type="HOGENOM" id="CLU_1545463_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="18962" checksum="9A685244700184DD" modified="2011-04-05" version="1">MPSLQPPPAAYYDTCERTSRFISSAESNYEVDPAWQGVETSRVLKQKIDVSHLQVDIANMAKLTNDWNGYDSPRPTTASLRAAMSVLDRFASLTIIPEKVTASADGGVALIFVGVEKQRAVIEVFGTEQDYVLLYDTDGNSFDIAWPIEVDSQNAVLSKLQSYLRGSQVAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R7</accession>
    <name>E8X2R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3356"/>
    <dbReference type="EnsemblBacteria" id="ADW70364">
        <property type="protein sequence ID" value="ADW70364"/>
        <property type="gene ID" value="AciX9_3356"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3356"/>
    <dbReference type="eggNOG" id="ENOG5032CJG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1842161_0_0_0"/>
    <dbReference type="OMA" id="TCEYCFS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="16878" checksum="BA27873C38067BB6" modified="2011-04-05" version="1">MPMLAMSLSHQFAYLMLLALPIACASWTVTHEEVFREPREYCKDRSQNCKPLVARKFFYLFTCEYCFSHYVTAFFLILTQFQMLYDGWRGYLIAWFALVWVANVYMSIFNRLRLEIKHENVVIATETAVQKRVEAEIPNSPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S0</accession>
    <name>E8X2S0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3359</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581679.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3359"/>
    <dbReference type="EnsemblBacteria" id="ADW70367">
        <property type="protein sequence ID" value="ADW70367"/>
        <property type="gene ID" value="AciX9_3359"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3359"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_0"/>
    <dbReference type="OMA" id="KNWLPIM"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="423" mass="44606" checksum="D5EDBF7815B4485E" modified="2011-04-05" version="1">MIRKTRLFTPGPTPLLPAAQFAMAAADIHHRTAEFRALYTRVLAQLKQFVGTETGDIIVLSSSGTGAMEAAVSNLTSPGDRVLVLTAGKFGERWTALAKAFGCEVDVVSAPYGQTFSLDEVKAALKLETRAVFMQATETSTGVRHCTPGVAKLLKDAGSEALLVVDAITGLGTTHLDMDAWGIDVLIGGSQKAVMIPPGLSYLAVGPKAWDRMEATYNPRYYFDLRKERKNARAGESAYTPAVALIAALGAALDWIAGQAATAENPAGSIAEGRKKLVDNAETIAAMTRAAMLALGMTLFAPDAPSSAATAVVPPAGVDSGIFVKELKSRFGAIITNGQGEMKGQIFRIAHLGFFDYMDTIALIGALEQVIVKSLPQLNAQFGTGLIAAQKLYAEASHPKAEAQKCLCGRTDKACSMQNPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W3</accession>
    <name>E8X2W3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579420.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1034"/>
    <dbReference type="EnsemblBacteria" id="ADW68097">
        <property type="protein sequence ID" value="ADW68097"/>
        <property type="gene ID" value="AciX9_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1034"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_0"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45405" checksum="AB8D82ECC97B3401" modified="2011-04-05" version="1">MIAEIIAAGSEMLTPFRQDTNSLYLTEGLNDLGVTVAFKTIVGDSLDHLTEAARNALQRADIVIFSGGLGPTEDDLTREAAAAALGLTLHPDPAIIAALYKRFAERRIAITPNNAKQADILDGAMLLENKNGTAPGQFLVTTYRGKKRYVALLPGPPKELKPLFDEQVKPRLAALLPTRFLAKRLLRMALIPESQVDARTSPIYKLYEDVETTILAGSGEIQLHFQCVAATLAQAQARVDELAERIEREMGDDIFSSHGESLDEVILLMLGMRHQTLATAESCTGGMLAQRLTAIPNSSRAFIGGAVTYSASMKALFCNVPPELIESQGAVSEPVARAMAEGIQTTTGASYGIGITGLAGPGGGSQGTDEGKPVGLVYIGITDATGPEPVTQIKQLQLMGDRERIRWWATQHALELFRRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X347</accession>
    <name>E8X347_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein family UPF0126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2229</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580587.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2229"/>
    <dbReference type="EnsemblBacteria" id="ADW69271">
        <property type="protein sequence ID" value="ADW69271"/>
        <property type="gene ID" value="AciX9_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2229"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064906_3_1_0"/>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="OrthoDB" id="1665397at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="216" mass="22646" checksum="FADFB77898F3387A" modified="2011-04-05" version="1">MLPERLHLQTLISALDFAGIAIGSIGGALHARQHARYSYDIIGAFGLALTSALGGGVVRDLLLQHGPPLALTDVWYLYTALLAAAAALALGSIIGTRTQRVMLFIDAAAISLFSVAGTTRAQSFGLSWLPAIILGVTTAVGGGSLRDILSGTTPRVFERGNFYAIAALAASVSYLLLDQTSLSDTANVLIAVAVGFTLRMLSVHFNWTTDPIRPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X380</accession>
    <name>E8X380_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2266</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580620.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2266"/>
    <dbReference type="EnsemblBacteria" id="ADW69304">
        <property type="protein sequence ID" value="ADW69304"/>
        <property type="gene ID" value="AciX9_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2266"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_3_0"/>
    <dbReference type="OMA" id="AREGCHT"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20975" checksum="194A6F4571F306D3" modified="2011-04-05" version="1">MPQQPTTIRPGTPADLEPMYQLDRLCFDAPFRFSRAAMRHFASEQGAFTLVAEFQQNSGAPSIAAPHRDGWDATSPPAGTPSTQAPTLAGFIIIHLEHIHPRTQAYVVTLDVAPEHRRQGLARRLLEAAEQQSATRQASPMTLHVWTENTPAINFYERSGYVRTVLHPNMYAPGKDAYGYLKALTNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X394</accession>
    <name>E8X394_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581707.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3388"/>
    <dbReference type="EnsemblBacteria" id="ADW70395">
        <property type="protein sequence ID" value="ADW70395"/>
        <property type="gene ID" value="AciX9_3388"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3388"/>
    <dbReference type="eggNOG" id="COG2308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017048_2_0_0"/>
    <dbReference type="OMA" id="VLTPGMY"/>
    <dbReference type="OrthoDB" id="517836at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016450">
        <property type="entry name" value="UCP005522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005522">
        <property type="entry name" value="UCP005522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="488" mass="55068" checksum="66FBF50CA98D133E" modified="2011-04-05" version="1">MTQNHSKQFDEDALKNYLLDNAYDEMFESPANLHEQYRPLLNHFSSLPEGELERRKQAADLSFLNQGITFTVYGREEGVEQIFPYDLLPRIITSKEWETVERGLTQRIIALNLFLRDIYNEGRILADGVVPREVVYSCKHFRRQMVGLQVPRNVYVAVCGTDLIRMEDGEFVVLEDNLRVPSGVSYMLTNRRVMKRIFPQMFRSYNVRPIEQYTQALLGTLRSLAPEGRPEPNIVLLSPGVFNSAYFEHAYLARQMGIELVEGRDLVTHDNVVYMRTTSGLRRVDVIYRRVDDDFIDPLAFRPDSILGVAGLFNAYRAGNVTLANAFGTGVADDKALYAYVPDIIKYYLNEDPVLQNVKTYLLTDPASRQHVLQNLDKLVVKAVGESGGYGMLIGPQSTKAEQAIFAEKIKADPRNYIAQPTISFSRAPCLIGDALEPRHVDLRPYVLYGDKVTIVPGGLTRVALKKGSLVVNSSQGGGSKDTWVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F6</accession>
    <name>E8X3F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3452</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3452"/>
    <dbReference type="EnsemblBacteria" id="ADW70457">
        <property type="protein sequence ID" value="ADW70457"/>
        <property type="gene ID" value="AciX9_3452"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3452"/>
    <dbReference type="HOGENOM" id="CLU_2699541_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="7830" checksum="B0BA74271A717634" modified="2011-04-05" version="1">MSQRAVSSHGLFLVPKRRLECVTSEVAAKGPVLVTWTAPAPKQKTASAFYILMTALAAPLVWVGHALFTGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K3</accession>
    <name>E8X3K3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ordered locus">AciX9_1131</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579517.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1131"/>
    <dbReference type="EnsemblBacteria" id="ADW68194">
        <property type="protein sequence ID" value="ADW68194"/>
        <property type="gene ID" value="AciX9_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1131"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_0"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="67"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="612" mass="66647" checksum="DA3EE4B9FEC6F163" modified="2011-04-05" version="1">MHRWSKLFIPTLREAPSDAEVASHKLLLRAGYVRQLGAGIYSYLFLGQRSVNKIVAIIRQEMDTIGQEFLLPTIHPREVWEESGRWTGMGDNMFRLKDRKGAELCLGMTHEEVMTTIARSELRSYKQLPQIWYQIQTKFRDEPRPKSGLLRVRQFIMKDSYSFDIDEAGLDLSYNLHDAAYRRIFDRCGLEYVAVEADSGAMGGSQSQEFMVYTDAGEDLIASSTSGYAANLEKATSALTPVIDLEPTGDGLPELVLTPGLGAISDVTAFFGIHASQDIKCVAFMGTRTAQPGTTEPLRPVVAFLRGDHFVNETKLNALAGTTELRPMLPEELQLFIGGPAGFLGPVGIAEVMTHGSLNGLNSGKPLDKLKGVSRENASEGLKTIVVMDKGLEGRANLVGGANKLDYHFRNITPGRDFTPTLTADLRNILEGELDPIGNLPLRLGKAVEIGHIFKLGYKYSKSMGATVLNRDGKEVTPIMGSYGIGVERILTAAIETSAAKNGGEAYALPASIAPFQVIVTVTNIKEPALVEAGEKIAADLAAAGLDVLLDDRDERAGVKFKDADLTGVPYRIAVGKKLSEGQVELLDRLQNQTLDIPVEAAVQTLRNLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L2</accession>
    <name>E8X3L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579526.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1140"/>
    <dbReference type="EnsemblBacteria" id="ADW68203">
        <property type="protein sequence ID" value="ADW68203"/>
        <property type="gene ID" value="AciX9_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1140"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_2_0"/>
    <dbReference type="OMA" id="QELHETW"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12512" checksum="5B001559EDDFDCEA" modified="2011-04-05" version="1">MLMTKRKPVGVGEMLVEEFLEPLGISQTELAARAGLPRKHVNELCRGRRSVTADTALILSRVFGNSADFWLNTQRRTDLWEALNTPKRLLRIERAKPISDRVSEKRVAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L4</accession>
    <name>E8X3L4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1142</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579528.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1142"/>
    <dbReference type="EnsemblBacteria" id="ADW68205">
        <property type="protein sequence ID" value="ADW68205"/>
        <property type="gene ID" value="AciX9_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1142"/>
    <dbReference type="eggNOG" id="ENOG5032VCA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1703376_0_0_0"/>
    <dbReference type="OMA" id="HKKQTTI"/>
    <dbReference type="OrthoDB" id="1903293at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="177" mass="19451" checksum="86E6C41E65FCF7E7" modified="2011-04-05" version="1">MSRNALLKTSRLIHLYFGVFITPALIFFAISGGLQTFGLHETNRDHPNYKPAHWLVVMGQIHKKQTTIVPVRKPQPAAAKPEAPPTPSSDLTAKPEHKHHDADSTQPASDAPKPTPAPEAPKPRPLPLRIFFLIVCVGLFTSTITGLIMSYKYVRNKTLITVTLIAGVVIPILLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P7</accession>
    <name>E8X3P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2287"/>
    <dbReference type="EnsemblBacteria" id="ADW69325">
        <property type="protein sequence ID" value="ADW69325"/>
        <property type="gene ID" value="AciX9_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2287"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051180_1_0_0"/>
    <dbReference type="OMA" id="MRIPPNY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="71"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26191" checksum="258FE636F52DE6EA" modified="2011-04-05" version="1">MNVLWYFERMQKFVGSFILAGLLSGLAGCKTDDGGRTSPEVAENNAPGPVEAPKAAIRKADVVDGRPLVVCFGDSLTAGYGAEDGASYPDFLQKDLDGAGYRYRVVNEGISGNTTKDGVDRLAGVERMKAAVVVLEFGGNDGLRGFDVKTTRANLATMIEGLKASGAKVVLAGITLPPDYGADYVTSFTANYPVLAKKYGVPVLPFLLKDVYGVPGMMQGDRTHATEKGNAVVARNVLPLVEPLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R0</accession>
    <name>E8X3R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron permease FTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2301</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580654.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2301"/>
    <dbReference type="EnsemblBacteria" id="ADW69338">
        <property type="protein sequence ID" value="ADW69338"/>
        <property type="gene ID" value="AciX9_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2301"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045824_0_0_0"/>
    <dbReference type="OMA" id="VPIEGWS"/>
    <dbReference type="OrthoDB" id="1663702at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018758">
        <property type="entry name" value="FtrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10080">
        <property type="entry name" value="FtrD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="FtrD-like" evidence="7">
        <location>
            <begin position="316"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45455" checksum="15340B28CDF037B4" modified="2011-04-05" version="1">MLQAFIITLREGVEASLIVGIVFAYLSKIGRPDLKKVVYWALGSAIAASVLGAVILSRTQFNSDIFEGWVMLAAAGFVVSMIWFMQKAAKSLKGEIESKIAKATLGSSNVGLFFFVFLLVLREGVETVLILSAVSLNSTELLSFTGTMLGIAVAVVFGVMFIRGSVKVNLQRFFRVTSVILYFVTFQLLVSGLHELSENGVLPSSTAEMRYIGPIVRNDLFFFVTMLALAVLMILMEQRRRGPAALPEGASAADKRRAEWSQRREKMWMTAVVSASFLFIFLSTAEFIYAKSATSLSATSPVTLVGDQVTVPTAEITDDKLHRFGVHVDDGNGASPEVRFLLFKKPDGNIVSVADACSICGPVGFYMGSQGITCKMCASPLVPASMGQPGGCNPIPLKSTNAGGQITIAAADLKALAPRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W8</accession>
    <name>E8X3W8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3471</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3471"/>
    <dbReference type="EnsemblBacteria" id="ADW70476">
        <property type="protein sequence ID" value="ADW70476"/>
        <property type="gene ID" value="AciX9_3471"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3471"/>
    <dbReference type="HOGENOM" id="CLU_1080792_0_0_0"/>
    <dbReference type="OMA" id="LWISELV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="27642" checksum="8B3917ACFCB8F66F" modified="2011-04-05" version="1">MIALGGAVAMQAKEMQAQELTGTARQRVLETARSRYYNLTGLGVKSFTCGVNFDLDTLSKGFLPAGDIADRALLQTAVFTLKVTSGGPTLKFQFPDGAQSQSEDVVAGATLWISELVQGFFQTWPLKGFAGPIPHQEKQLLGVAQDGEGYRITVKGPAGPMVLHLDRNSMVTEIQSQNGTASQIDEHPIFTSAPEGMVLTGNDTQDTEPNGTTRARYAIDIGRVDGFMIPQRVRLLVGEHVDVKFALSGCKVATAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L4</accession>
    <name>E8X4L4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2387</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580740.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2387"/>
    <dbReference type="EnsemblBacteria" id="ADW69424">
        <property type="protein sequence ID" value="ADW69424"/>
        <property type="gene ID" value="AciX9_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2387"/>
    <dbReference type="eggNOG" id="COG2321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059329_0_0_0"/>
    <dbReference type="OMA" id="QKRSQGY"/>
    <dbReference type="OrthoDB" id="1175086at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="32991" checksum="1DABB2210DF97AF1" modified="2011-04-05" version="1">MDWTPGGTSSDIEDRRDSSGGDGGGGGFGFGGGGGGGLGIVGFIIVLVISLVTGHNFLGSMMHGGGAPSQSYNGPSSAQYGPAVAGGPQRSPKAHPPGEDRDVQLISFVLDDAQKTWTRIFEGAGKQYRHAKLVIYRGATYSGCGTARSQTGPFYCPADEKVYIDLSFWDELKKFGGDTGDFAQAYVIAHELGHHVQKLLGTEQKEQMLVRQNPGKKNEYSVDLELQADCYAGVWAHSTQQRGIVHEDDIAGALKAAAAVGDDHLQSMSGRAVSPESFTHGTSAQREDWFRKGLTTGKVTACDTFGANAGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P8</accession>
    <name>E8X4P8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2421</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580774.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2421"/>
    <dbReference type="EnsemblBacteria" id="ADW69458">
        <property type="protein sequence ID" value="ADW69458"/>
        <property type="gene ID" value="AciX9_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2421"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_4_0_0"/>
    <dbReference type="OMA" id="AVNTRFA"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="12885" checksum="5FBF9A0BC111C7F8" modified="2011-04-05" version="1">MAQSGRFGLSVRVLGVLAAEPDAMHTSAAIAEAIGSSPVMVRRIFSALHKAGFIEQKKGPAGGARLKHSAKSIGLGDLFVAIEPDWLMSGEKALDAAMKKVRTAAVEAMNETSIAAVGKKLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X513</accession>
    <name>E8X513_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-3B synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0128</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0128"/>
    <dbReference type="EnsemblBacteria" id="ADW67205">
        <property type="protein sequence ID" value="ADW67205"/>
        <property type="gene ID" value="AciX9_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0128"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_2_3_0"/>
    <dbReference type="OMA" id="RMHMSGC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012798">
        <property type="entry name" value="Cbl_synth_CobG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02435">
        <property type="entry name" value="CobG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="200"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="383"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="461"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="602" mass="65364" checksum="7976AAB235A0F715" modified="2011-04-05" version="1">MPANGPLANPQNALTAPMLESAGDETFSVEQKQYLEGFFAGVIQRMPFVGHTAAGQITAEPTAGTQNLAATFHGTLVEDLCREELWKYERNPLDAWDELLSHSKENMAPNPENTYRFKFHGFFYVSPAQDSFMLRLRVPGAVLTSRQMRGLAEMADEWGAGRCDLTTRSNVQIRDFQPKHLVPVLNKIAALGMSSRGSGADNIRNITASPLSGIDPRSLLDVRPHADALAQYILNSRDLFGLPRKFNVAFDDGGTISAVADTNDIGFQAVRVSEGQSLPAGVYFRVLLCGITGHRQFATDAGVILKPHEAVAVAAAMIRVFAENGDRTDRKKARLKYLVDRWGMERFLEEAEKLLAFPLLRLPLADCEARGPIERAGHIGTHAQVQPGLSYIGVSVPVGRLPVDQMRAVAGIAEEFGTGEIRLTVWQNLILPNIPEARLPAAQAALTAAGLKFTAGPVLSGTVACTGNQGCRYAASDTKTHAVALARTLDERFPQLTQPINLHVTGCNNSCAQHYIGDIGLMGTKVEGEEGYVVSLGGGSDADQGIAREFIAAIKFADLPPVMELLLGSFVDLRSDENETFLAFTRRHSIEELRAFAQVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X514</accession>
    <name>E8X514_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0129</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578534.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67206">
        <property type="protein sequence ID" value="ADW67206"/>
        <property type="gene ID" value="AciX9_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0129"/>
    <dbReference type="eggNOG" id="ENOG502ZBS4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568347_0_0_0"/>
    <dbReference type="OMA" id="AVYYRSS"/>
    <dbReference type="OrthoDB" id="472285at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234385" description="Alginate_exp domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="3">
        <location>
            <begin position="178"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="548" mass="60206" checksum="212D2281620F49F3" modified="2011-04-05" version="1">MTRFPARTALLALSALSLSMHLAAQDAPLLLAAATEPAVSSSNGPELQNGPTPQTATSPQPATNKLPSGFLGSPIATGTVKRTYPVSISFLSRNRADALNYYDDGVYTSTYPYVEHLLRIAIAQKVGKFDWQAELAENTVFDVPTTAVDPVAARGQLFLGGTYYASNGPLNTTPSAASFKQGWLRYHGKGPDTTLRLGRFEFFEGQETTPKDPTLLWLQTNRVAQRLVGNFGFSNGQRSFDGIDGHYGKGTWDITAMAGRAIQGVFNMNSNPELNVDIQYLAYTRRQFKDRLIFRVFGLDYHDARTGLTKTDNRTAAARALDHRNIRIGSYGADLLGTLPTGPGAFDGLFWGVVQNGQWGVQNQHSGAYAVEGGYRFTKVASKPWIRGGAFRSTGDNNNTDDQHNTFFAVLPTPRVYARFPFYNSINSKDQFIQIMDSPSKRWDLRSDMHFLQLTSSTDFLYNGGGAYDNKVFGVTGRTANGHNSLASIFDISSDYAVTPSLSLNTYYAHSYGRTVISALYAGKQANYGYLELIYKFGIKQRAAKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X520</accession>
    <name>E8X520_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0136</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578540.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0136"/>
    <dbReference type="EnsemblBacteria" id="ADW67212">
        <property type="protein sequence ID" value="ADW67212"/>
        <property type="gene ID" value="AciX9_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0136"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070025_2_1_0"/>
    <dbReference type="OMA" id="NVGCTRE"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="137" mass="14209" checksum="34C27E0572B4D8F1" modified="2011-04-05" version="1">MANELTPSATDTLYKLGSETFTSSLGTSAAEFEKGFEDIAPGFGRLILEAEFGTAYHRPGLDLKTRELIIVATCATLGATGYGAAKMHIGAALRAGATRAEIVEALVQITFAAGLPTSIGALEAARDAFAALDKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X557</accession>
    <name>E8X557_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ordered locus">AciX9_1259</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579644.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1259"/>
    <dbReference type="EnsemblBacteria" id="ADW68321">
        <property type="protein sequence ID" value="ADW68321"/>
        <property type="gene ID" value="AciX9_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1259"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_0"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="347" mass="37050" checksum="8A1E96C719366E4F" modified="2011-04-05" version="1">MIPTLEWLPEGINFLDQTKLPLEETYVLATDYKQVATVIRDMITRGAMVIGVSGAMGVAIGIDRSTATDIPTLNAEVAEICDHLAATRPTAVNLFWGIGRVRDLYNTLAAANTPIPEIKKAVVALSLEMYDEDIANCRTLGAFGADLLPQEGTILTHCNAGALAACGYGSALGVIRAAVEKGHKISVLADETRPYLQGARLTAWELMKDNIPTTVLCDNMAASLMSKGRIQACIVGADRIAANGDTANKIGTYGVAILAKEFGIPFYVAAPWATLDLATATGDLIPIEQRDAREVTHSNGRQMTPTGVGIENPAFDVTPFKYITAIITERGVLKAPFEESIRAMAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X570</accession>
    <name>E8X570_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1272</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1272"/>
    <dbReference type="EnsemblBacteria" id="ADW68334">
        <property type="protein sequence ID" value="ADW68334"/>
        <property type="gene ID" value="AciX9_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1272"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="TWMYRIV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="30489" checksum="C40332AF4B3C6FF0" modified="2011-04-05" version="1">MGNIFPKKDTLSPTKRSRTSSAKPTPPPPYTPQSFQDHAPNNPDRVTFSLYLTPMKGEGPRSMLEAPNPRNEPQMIAAILAGDNELFHELIRPYERSVFAMAISLLRNEADAEDAAQEAFLKAFRNLHAFRGEAKFSTWLISIALNEARGRLRRQNILPMESLDDEPEKISPALLRDWREIPSDALERQEVRLMLQDAIAALPPHYREVFLLRDVEELSTNEAATVMQISVASLKVRLHRARIMLQKNLAPQLKKMNPKRRWFQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5N3</accession>
    <name>E8X5N3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="12" type="ordered locus">AciX9_3657</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581971.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3657"/>
    <dbReference type="EnsemblBacteria" id="ADW70660">
        <property type="protein sequence ID" value="ADW70660"/>
        <property type="gene ID" value="AciX9_3657"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3657"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_0"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="11">
        <location>
            <begin position="52"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="973" mass="107325" checksum="86111F6A2E105AEF" modified="2011-04-05" version="1">MADDLFPEDPSTPEVPDSQDASSNNPPPAGTPPDDPKYGQVQGRGALIMTSINIEEEMRRSYLDYSMSVIIGRALPDVRDGLKPVHRRILYGMQEMGLQFNKKYTKSAKVVGHVMGNYHPHGDSAIYDTMVRLAQPFSLRYLMVDGQGNFGSVDGDSPAAMRYTESRLTRLAGEMLADIDMDTVDFVPNYDESTLEPSVLPARVPNLIINGSSGIAVGMATNIPPHNLTEVVSACISLLQKSPQDTTPDLELVLQHVLGPDFPTGGTLFGRTNIPQAYRTGRGRFMMRAKCHIENISGGRQAIVVDEIPYQVNKSKLIERIAELVNEGIITDIARDEFRDESDRDGMRIVIGIKRGAEHQIVLNQLHKHTQMQESFSMIFLAVHNGQPKELPLDKAIRAFLDHRIEVVRRRTAFLLAKARDREAILLGLQIALDHLDQVIRIIRQSSSRADARENLFAYFSNRTITLRGTELRGITLDPAKYGIDPRLIPPPPANAGTGATLILAYRQIDAILELQLYRLTQLSIDELLKELALIRDNIAEFESILNSPAKLRQVIADELAQIRDKYGDPRRTIILDETAELGLEDLIADEQVAVTVSNTGYLKRTPISTYRQQRRGGTGRIGMKTRDEDFVAQLIIESTHAYLLCFTNSGRVYWLKIYEIPDTGITGKGKAMASLVDLQPGEKVVTILPVKNLTEEGKNILFATRNGTVKKTPLKDFSNVMSRGIIAIGIDKEDELITARITTGSDVVFLATHDGMAIRFNEQDLRPMGRPATGNRGINLRKGDFVIGAAVTPSPEAREKQRRERAEALGLLAQLEDAITEATDASLVLEGDPSDVAAAPPVSSAKLDKLDEKLGLTPCLILTVSENGFGKRTDVDRYRLQSRGGTGVINMKTGTKTGKVTSISLVDDTTEMMLISQFGKIIRIDTKQVRAAGRSTSGVKLLDLDQDDKVAAAMTIPPEDPKEKLENGTLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S7</accession>
    <name>E8X5S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase with beta propeller sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4015</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572723.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70811">
        <property type="protein sequence ID" value="ADW70811"/>
        <property type="gene ID" value="AciX9_4015"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4015"/>
    <dbReference type="HOGENOM" id="CLU_012402_0_0_0"/>
    <dbReference type="OMA" id="SYITISI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="829"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="975" mass="107019" checksum="A3864C3AEF1F1BD2" modified="2011-04-05" version="1">MALLAVLGALAPMRCSALDDRKQLTQYVQMTLTDRNGLPQNSVDAVAQTTDGYMWFGTQEGLGRFDGLTTTVFDASHNRDFRDAFVKTMASSRDGSLWIGTRSNLTHMQHGAFHTVLSAQSPINTIHEAQDGRIWVGTGRGLYSVDHDVVHFFTAQDGLPSASVQSIVETRDGSLWFGTEKGLFRRKGGKVEAFGAKDGAPGASIQGLAVGQDQSLWIGSTEGLSHWNGKLLQNWPEAMMPPHARISSLLVDHNDHLWIGFEHSGMATLRDGKLERYTVQQGLPNDDVAQLFEDHLGHLWVGLGEGGVLELRDGLFTSFGVQEGLSENMVWSVLQARDGSFWAGTDSKGLDHIFKDGSVQVYGLKEGLPGGTVFALHEGLDGSLWIGTEHGILSHLKDGKIENFRDPAGSEGRLQMIMDAPDGDMWLGYYENDGLVRYHLGTFTHYAIPGLLNTASFAADGSMWLGTDHGGISHVRDGKVLQTLTKQDGLLSDFSQAVYVDKEGVVWAGTSPGGLNRIKNGRITTYSVEQGLANLTVGAIVEDSLGNLWMTCNKGIFRVSKKELNDYAEGRVSSIHSIMYGTADGMRSAECNFGANPSVWRDVENRIWFATTAGLVMIDPAHSETVKSTPLPFVEHVLFNRRPAVFDVGEPIGLGTGDVEIKFTAPDFVAPEQVRFRYRLKGFDQDWVDVGDRREAYYTRIDPGKYQFEVQAGNQNGEWNGYTAVLPLTITPHFWQTTIFQLCCWLSALLLGALMYRIRIRFLVRRNQTLETRVSSRTKELQEALQAAASAHDALHEQATKDGLTRLWNRRAILEILTREVDRARRDSGSVCVLMVDVDHFKRVNDTLGHVAGDCVLEEVAARINGLIRPYDSAGRYGGEEFLVVLPGCTLADGLQRAEEFRYAIANEPTCVDAGSIDVTCSFGVAAESGTSAEHLIISADQALYAAKHAGRNRIQAMLGEATVEVGPLLTEITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z6</accession>
    <name>E8X5Z6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4100</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70880">
        <property type="protein sequence ID" value="ADW70880"/>
        <property type="gene ID" value="AciX9_4100"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4100"/>
    <dbReference type="HOGENOM" id="CLU_2935052_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6598" checksum="D80A82E6DA1372A5" modified="2011-04-05" version="1">MSDILCAIVAVSLLFIVYLWAFACDRRCLQKFVSAQRIAKTSARPPTGETLTESPARPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X678</accession>
    <name>E8X678_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND efflux system, outer membrane lipoprotein, NodT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4183</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572874.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70962">
        <property type="protein sequence ID" value="ADW70962"/>
        <property type="gene ID" value="AciX9_4183"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4183"/>
    <dbReference type="HOGENOM" id="CLU_012817_13_1_0"/>
    <dbReference type="OMA" id="ARGAWWE"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="523" mass="55771" checksum="5D3AABB9CE248F27" modified="2011-04-05" version="1">MGNKLVLSFAAAGVMVLSGCRVGPRYVAPAPPAPPAYKESAPTAYSGATDAVWQPAQPQDAMLKGKWWEIFREPELNGLEDTLNIDNQNIALYFQNFMAARSQVKQAKASYYPTVGVAPAYTREKSPSTLRGVGVSSGTTTGTGTTGTTGTTGTSTTSTGGTYTDLSLPFDVSWEPDLWGKIRNTVREYQYATQVSAADLENERLTEQADLAEYYFELRGQDALQQVYDATIDADRKSLDLTKVLVETGIDSPEAVAQAEVTLKNAEEAGAGVAQNRAIYEHAIATLIGKPASSFSLPVRAATPAAPAIPVGVPSQLLQRRPDIAAAERTMAEANALIGVEKAAYYPTLSLTGTGGLESSHISSLFSVPAFFWTLGASASETIFDAGLRKATVAQYTAQFNADVASYKETVLTAFQQVEDYIATLRVTSQQIAKQQEAIDAAQRYVDIATARYQTGLDPYLNVISAQTTLLSDQQTQVTLKVSEMTAAVQLIQALGGGWDTALLPGASQVNTNGAVRQVSQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A1</accession>
    <name>E8X6A1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_4207</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
            <plasmid evidence="14">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572897.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70985">
        <property type="protein sequence ID" value="ADW70985"/>
        <property type="gene ID" value="AciX9_4207"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4207"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="OMA" id="VEACDRK"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230785" description="Beta-glucosidase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="449"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="489" mass="54620" checksum="D5FAA13824039DF7" modified="2011-04-05" version="1">MSDKLSRRSFAKVIGGSTAALSLANLGTTPASAQAAPAISTDPRRHFPQGFLWGSATASYQVEGAVKEGGRGPSIWDTFSHTPGKVANGDTGDVADDYYHRYKEDIALMKDIGLKTCRFSVSWSRIFPTGTGQPNQQGVDFYNRMCDSLLEAGIQPFCTLYHWDLPQTLQDKGGWENKDVAKAFADYAGYTANKLNDRVKHFMTMNEMRSFVEIGYKDGRHAPGLRLDAKRVAQLNHYVVLAHGLSVQAIRAQTKPGTKVGIADNATATAPVIETPEHIEAARKAYREENAMFLTVLMEGRYTDHYLKRLGADAPHFTPEEMKTISAPMDFVGLNVYQPEYVRADGSDKGYTVVPSPASYPHMLSPWLHVGPEGLYWSPRLCAELWNVKEIYITENGASSADVLAPDGQVYDTDRTMFLRNYLTQLQRAVAEGVPVKGYFLWSLLDNFEWADGYDKRFGITYVDFKTQKRTPKLSAKFYKQVIKENRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E4</accession>
    <name>E8X6E4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase cyclophilin type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71028">
        <property type="protein sequence ID" value="ADW71028"/>
        <property type="gene ID" value="AciX9_4252"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4252"/>
    <dbReference type="HOGENOM" id="CLU_082529_0_0_0"/>
    <dbReference type="OMA" id="WNITIPN"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="25164" checksum="A6FCA9C370F423A0" modified="2011-04-05" version="1">MMDYILWLVLAAPFWLSHYAPKVFRVRVDTTVGSFVIETHRAWSPHGADRFYELVRARYYDDNRFFRVVPAHWVQFGVNGNPQVAQQWRHRTIADDPLLCHNTPGFIGFSNTAPNTRSTQVYINTGDNSARNDVEAGFAPFGRVVEGMDIVEKIYSGYGEHSGGGMRAGHQDQMFAGGNAYFDREFPRLDKLLSVSLISFDQPSLPDNICHAGNEHPKPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G6</accession>
    <name>E8X6G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4279</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572962.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71050">
        <property type="protein sequence ID" value="ADW71050"/>
        <property type="gene ID" value="AciX9_4279"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4279"/>
    <dbReference type="HOGENOM" id="CLU_2395592_0_0_0"/>
    <dbReference type="OrthoDB" id="780694at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="93" mass="10169" checksum="1E1034A57E9A3C50" modified="2011-04-05" version="1">MGKGRNRCAVESGFNLVTGDGRAEIEFEVNSTAYLAPNAVLMFDTLTPTDSAPHSVLKLLSGSLTLHVKTLFPSRDFQVSTPNDLIRLTYPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I3</accession>
    <name>E8X6I3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4299</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71067">
        <property type="protein sequence ID" value="ADW71067"/>
        <property type="gene ID" value="AciX9_4299"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4299"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="LMREVWD"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="25012" checksum="5EFF6C5ECBA81707" modified="2011-04-05" version="1">MIDDDVALTDSLRRLLAMDGLRLDAVHRAEEGLTRALEGRHAIVILDIMLPDGDGRQILRRIRQASEVPVIMLTARGDDKDRIQGLEAGADDYLPKPFNPRELVARIRAVLKRGRPPAMPAAALTIDGLTLRTHTRKVTLNNETIDVTGAEFDILLLLVQSAGQIITREKLAQFALGRDLGAFDRSIDNHVSNLRKKLGPLPDDGERIRSVRGSGYLYAGELIVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S8</accession>
    <name>E8X6S8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-6A synthase (Deacetylating)</fullName>
            <ecNumber evidence="5">2.1.1.152</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3952</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.152" evidence="5"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582246.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71228">
        <property type="protein sequence ID" value="ADW71228"/>
        <property type="gene ID" value="AciX9_3952"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3952"/>
    <dbReference type="HOGENOM" id="CLU_098653_0_0_0"/>
    <dbReference type="OMA" id="ARHGWIM"/>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="28760" checksum="72F7CF28185767C8" modified="2011-04-05" version="1">MRHLFIIGIGAGHPDYITIQAVKALNLVDIFFFMNKGDSKDELVRLRKDICERYIEHHPYRIVESVDPIRDESIPDYKTRVQQWHLERVQIYEDLIANELSEDATGAFLIWGDPSLYDSTLRIIDQIVARANVPFTYDVIPGITSPQALAARHRIPLHDIGESILITTGRHLASGKPIEPENILVMLDGHAAYKDIPDQQTQIYWGAYLGMENEILLSGTLEETAPKIEAARAEARERNGWIMDTYLLSKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V0</accession>
    <name>E8X6V0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71250">
        <property type="protein sequence ID" value="ADW71250"/>
        <property type="gene ID" value="AciX9_3976"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3976"/>
    <dbReference type="HOGENOM" id="CLU_136060_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15676" checksum="F888B551F183A01A" modified="2011-04-05" version="1">MNAHWRASAAGEIDAEHDIYDDDVLCEYPQSGERILGRVNLQALRGHHPGRPSGFEVRRIFGEGNLWITEYTIIYQGKPAYTVSMMEFRDGKVVHETQYFADPFDAPGWRSQWFKARREACRWVRCPRLSSLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V3</accession>
    <name>E8X6V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3979</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71253">
        <property type="protein sequence ID" value="ADW71253"/>
        <property type="gene ID" value="AciX9_3979"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3979"/>
    <dbReference type="HOGENOM" id="CLU_882138_0_0_0"/>
    <dbReference type="OrthoDB" id="1313451at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="34817" checksum="E4B70A47510ED2E4" modified="2011-04-05" version="1">MRTPPVSAYLTTLSMLAMVIVPAAFTLHTVRVSAFGGSLPANPSPYGYTVSLLLFLVPSLVILCWFLPQEHLHISRRSFMVSLSLLFPLGAALDFFFARYFFVFPNASATLGIKAPALGGGVPVEEYVFYLSGFALVLLLYVWLDEYWLAAYTVPATARERISFDRLLRFHPASLVLAVTLLAGVLIYHHLTAPGSFPGYPVVLILGALLPSSALLPAARPVINWRALSLTMFIILVTSLMWEVTLALPYGWWNFQAAAMLGVRVTAWSFLPIEEVFIWIAVSYSSVIVYEIVKRWKASGRALGHALLGARLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y7</accession>
    <name>E8X6Y7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Selenocysteine synthase (Seryl-tRNASer selenium transferase)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3810</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582118.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71096">
        <property type="protein sequence ID" value="ADW71096"/>
        <property type="gene ID" value="AciX9_3810"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3810"/>
    <dbReference type="HOGENOM" id="CLU_040896_1_1_0"/>
    <dbReference type="OMA" id="GKKTWIA"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234266" evidence="3">
        <location>
            <begin position="32"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="421" mass="45707" checksum="A317667B86AE0243" modified="2011-04-05" version="1">MANTLDQLTRRRFLGWSQALLAAFSTRPLLAATTPPATPTSDDDYYAKLGVPIIINAAGTYTYLTAAVMPPQVQRAVAQAALHPVVLKDLHKAAGEHIAKRLHCEAALVTSGASAALTLATAACLSAANNVKPEQIPEVIPSMKNEVIVQKSHRYEYDHAMLLCGIRIVEVVTLEDYKKAFGPKTVMTNFFNSADGDGQIDRKTWLEVAHQHNVPCHMDAAADMPPIENLWKYTGMGYDLVCFSGGKGIRGPQNAGLLLGKKSLIDLAAENDSPNSDAVGRGMKVAKEQIVGMVAAVDWLLEQRDEANQAEYMKRVDTIVAKLKSIPTMKTEVFMPEIANHVPHLILAYDPKVVGITPLEVKARLSAQRPQIELNPATGYTGRLGTHSNENTIVIATWMMQPGEAEIVATHLHAVLTNPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X773</accession>
    <name>E8X773_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4355</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71307">
        <property type="protein sequence ID" value="ADW71307"/>
        <property type="gene ID" value="AciX9_4355"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4355"/>
    <dbReference type="HOGENOM" id="CLU_1553119_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="19114" checksum="417517CC574C6EA3" modified="2011-04-05" version="1">MLDVSRPYPADTPITGISRLQAQRDESREESSLILVEPDLSFLPDRALMLTEASYRVTTVRDIRELASLCSPRLFGIALLSELLGPAALDFAARFVRTEWPGARILFLGASQRVLEDHLYDERIEASCKPHELLKAIGTLHRTRSTARPFIVPALAANTTLEPKVSSSKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C5</accession>
    <name>E8X7C5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573078.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71359">
        <property type="protein sequence ID" value="ADW71359"/>
        <property type="gene ID" value="AciX9_4409"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4409"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="OMA" id="IAPHISQ"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="28133" checksum="0BC2AF6EA8290A2E" modified="2011-04-05" version="1">MPHRKLKEFDPVAFLATSGLGRRILHIKAKGTMFSQGGLADSVFYLQKGRAKLTVVSKAGKEATITLIAAGDFVGEEAATAIAGLHMSTATAITACSVLKIEREEMMRVIHDEHAFSDLFVAFLLERSMRTQADLVDQLFNSSERRLARILLLMADFGKPGEPETKIPKITQETLADMIGTTRSRVSFFMNRFRKMGFIEYNGRIHVHKSLLNVVLHDQRPGANSISAALLDTKRDKTKLAERASASAKRSEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E0</accession>
    <name>E8X7E0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4426</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573093.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71374">
        <property type="protein sequence ID" value="ADW71374"/>
        <property type="gene ID" value="AciX9_4426"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4426"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="OMA" id="VHHQTLG"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="49"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="108"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="34946" checksum="07895002960B2A6E" modified="2011-04-05" version="1">MKIAFIHQKDQFSEKLLEGLRAKFSDREVLSWIEGEEPPTRDLEILVAMGPVTREDLNSQPKLGFIQTATAGYENVDLEAAGELGIWVSSAPSGMTGNAESVAEFAILLLLAASRRLGTFLKSEEDRALHPTQIHPALSGKTVCIVGLGAIGERIVERLRAFGVKIVATDEHPENAPHGVTAYSPNQLKKAIADADYVVLGIPASKANEDLINSDMLHAMKRGAILVNIARGALVDEQALIEAVKEGQIAAAGLDVVKNEPLALSNPLLQFPQLVVTPHIAGFTDIMLHGTIDYVGQVIEDVTANKRPNSVVNLPKAPRRPLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S4</accession>
    <name>E8X7S4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4578</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4578"/>
    <dbReference type="EnsemblBacteria" id="ADW71508">
        <property type="protein sequence ID" value="ADW71508"/>
        <property type="gene ID" value="AciX9_4578"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4578"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017156_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230864" evidence="1">
        <location>
            <begin position="23"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="40"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="196"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="845" mass="88292" checksum="2DD7CE50895A7D44" modified="2011-04-05" version="1">MNCVRARSFEMLGLMIFATLLAAPLLGQSEGSPELNVQAGPYTLSPNSTTSACMDLRSASSVNGTAIQAYSCNGTNAQSWSLVPISGSAGNGYQVVSVSSGACLDVSNASTTNGALVQEWQCIGGNQANQIWQLFPFGSAYELVSLNSGKCLDLSGGNSGNGTQLQQWSCGQGSNTNQLWNFHPFSPEGTAQLNLSVGPYRISPVSNPSACMDLNAASSANGAAVQSYSCNGTNAQSWTLVPVSGNAGGGYEVVSSSSGACLDVIGVSLANGAHLNQWQCGGATKLNQIWQLYPYGNAFELVSLNSQKCLDLPNGNSANGTVLQQWSCGEGSNSNQLWTLAALSNAVGVVATATSLTASPNSTVPGQTVGMTASMSNPSTAGNVTFFDGATSLATVTLNGGTASFATTALANGTHSLTAQYVANAAYSASTSPQVQVTVSPSAVGEQASQSQVFFDSVGVETHISYLNTAFGTQWPAVLQEIKSLGVHHLRDGYYDWPSSSSIVLNHQSLAALGITTTYVVPLNFATTVAQIREASANLQDMEMLEASNECDVDPACGGPGLLGIANVVSFLPTVFAAGKSLGIPVLGPSFTTSQAYAAAGNLASHMTYNNLHVYFGGRNPGSNGWGDGDAQGNRYGSLAWWMDQGNVDAPNVPDIITETGYYAVPTPYPYQISEEVGASYIPRTYLLAFNHGVKRTFVHELIDEAASPFFGLLRYDLSERPAFTAIKNMLSIVTDPGTSFTPGKLNYTFSGGDSTLNHTLLQKQDGTFILIAWLEQSSYDEVNDVNTPVNPQTITLTLNGAAAVNNVTQFDSSGNTHGVGISGSRTTVPLTINDQLTVIQITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X0</accession>
    <name>E8X7X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma 54 interacting domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4624</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573273.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71554">
        <property type="protein sequence ID" value="ADW71554"/>
        <property type="gene ID" value="AciX9_4624"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4624"/>
    <dbReference type="HOGENOM" id="CLU_405395_0_0_0"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TrwB_AAD_bind" evidence="3">
        <location>
            <begin position="217"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="728" mass="80914" checksum="DD33851DA86D50E6" modified="2011-04-05" version="1">MPDNAWGRKETLVFPPHVPIYSYFALGLALLLTLLFGWEHLRFGTTPLEKAYSGAYLRSSAGALFKAHGNYQLVYLGGPKVQPRRALPVDFEDGETVFPDGHRLPVQLSALPLSQGYRGFYTGKPETFTDVAMSRWLRGAIFEGDTFIGSYAVSLGWAALSLVALLALSIPAEMKRFRQMKYGRLLRGPVLMKPEEFVRKQKGDGIGFNSVDMEEKIRIPARKEAQHFLMMGDTGVGKTQLITQLLMQVAERGDSAVVYDPATEYVQKFFDAERGDIILNPLDARCPYWGPAQEIESNAEADAVASSLYQPTGEGKDEFFHQTPAQIFAHLLKYGPTPHQLADWLASDDELLAKVEGTEMAFYIDRNAGPQRAGVLSSLGIVAKSFRLLPTKKEANGEWNARSWSKTRKGWVFITSRPTERNTLRPLHSLWIDLLVMRLMNEPAPNQRKVWFVIDELASLQRLPQLHTALTEARKSKNPMVLGFQGRAQLQAIYGDKLAEVMVSQPATKLFMKTAEPNAAQWISKAIGYVEIERVKETKHDGAKQGRNYSLDRQIEPLVMESQIAGLDDLHAYLKHGNNVAQFNFNYISLPKVSPGFVSRTGAEGELSFDPDTLKPRPPKPGAASKHAAAAEAPATPTAGFEEPPEEAETVVTEAAETVAPAPGGEVGTEATEHRKSRKSRKKTEQKEAQPEPELEAEILQEECLSRELDPPKAGPEKPSNQHHFIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X809</accession>
    <name>E8X809_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573312.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71593">
        <property type="protein sequence ID" value="ADW71593"/>
        <property type="gene ID" value="AciX9_4663"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4663"/>
    <dbReference type="HOGENOM" id="CLU_027402_27_5_0"/>
    <dbReference type="OMA" id="VISWSIG"/>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="344"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="512" mass="58873" checksum="F6A1F7C890E37399" modified="2011-04-05" version="1">MYSYEDRIRAVRLYVELGKRGAATVRQLGYPTIRALNRWHKQYQRGHDLPAGYVRLRPKYSAEEKQAAVDHYLNHGQCLAWTSKSLAYPGRGTLARWVDEQRPEARKRIVGKVGALPQPRETKEAAVIELCMRQESARVIAQRVGVSRPTLYNWKNELLGREVPTTMKRHNDPPLASERTALEGQVESLQRDIQQLQLEYDLLKKANELLKKDLGIDLHLLTNREKTLLVDALRQTYPLSQLFGALGLARSSYFYHRARLQVAEKYAGLRDVITEIFKGNHSCYGYRRMRAALVRRNISLSEKVLRRLMKQEGLAVSTARRRRYGSYLGEISPAPENLINRDFRAAAPNEKWLTDITEFQISAGKVYLSPIIDCFDGLVISWSIGMRPDAEFVNTMLDAAIETMAKRDSRPVIHSDRGAHYRWPGWLTRISDAGLVRSMSRKGCTPDNAACEGFFGRLKTEFFYSRNWKTTSIEQFIKEVDAYIRWYNEKRIKISLGSLSPLEYREKLGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X824</accession>
    <name>E8X824_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rap1a domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71608">
        <property type="protein sequence ID" value="ADW71608"/>
        <property type="gene ID" value="AciX9_4679"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4679"/>
    <dbReference type="HOGENOM" id="CLU_2301872_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041238">
        <property type="entry name" value="Rap1a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18602">
        <property type="entry name" value="Rap1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap1a" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="11040" checksum="4926FEA667270354" modified="2011-04-05" version="1">MAQTSGLGLYQSCQLTTKPENSLSENDHLRYVTCVVFVTAITMGYEMGTKTRCVAAGTTNTQLGIIVYKYLDDHPEMLNLDPGTLTIRAVRQAFPCPVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X845</accession>
    <name>E8X845_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4702</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71629">
        <property type="protein sequence ID" value="ADW71629"/>
        <property type="gene ID" value="AciX9_4702"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4702"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="DVWVPPD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22332" checksum="9220C0506261EB85" modified="2011-04-05" version="1">MSPSEKPITVVLAEDQGILRSSLTIMLGIEPDIKVVASVSNGAEALRAVGLHLPAVLVTDIEMPQVTGLDLAIRVKELYPSTRVLILTTFARPGYLRRALDAGAVGYLLKDCPSTEMAEAVRRVAHGERVIDPGLAAESWSADAGPLTEREREVLRRAGEGESTAELARTLRLTEGTIRNYLSEAISKLGAHNRTEAARLARAKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV94</accession>
    <name>E8WV94_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0195</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0195"/>
    <dbReference type="EnsemblBacteria" id="ADW67269">
        <property type="protein sequence ID" value="ADW67269"/>
        <property type="gene ID" value="AciX9_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0195"/>
    <dbReference type="eggNOG" id="COG4798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_16_0_0"/>
    <dbReference type="OMA" id="LKVYHEI"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="236" mass="26245" checksum="A2D841FE75A7FCA7" modified="2011-04-05" version="1">MSRFWDVGFQNSQGPHTLRHPGIQSQMKLLAILTAATLTLPLTAQQPRPTSTPYAGDLSIFEYPDRDQKLEIDRVMTLLKITKGKTVEDIGAGSGWFTVRAAKRVGPTGTVYAEDINPEAIKFIDQRAHKENLTNIKEVLGTPDDPKLPAASTDAVMLLKVYHEIARPIPFMQSLRASLKPGARVAIIDRNGTGTDHGLNQNIVEQEMTEAGFHEIAHYDFTKKDGQDYFLIFQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVA8</accession>
    <name>E8WVA8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0209</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0209"/>
    <dbReference type="EnsemblBacteria" id="ADW67283">
        <property type="protein sequence ID" value="ADW67283"/>
        <property type="gene ID" value="AciX9_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0209"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_11_0"/>
    <dbReference type="OMA" id="KLYAIRH"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="29511" checksum="82210A4BF3E8D53B" modified="2011-04-05" version="1">MRVWLLCDAVNAMVDSINIAGQPTASLRKQQRGLVTRQELLRSARAIFARDGFEHARIEDIAANAGRTRGAFYDNFKDKEDVFYAIFEENIDRDLAELAPRLASLPVMEEREAALADYLSGLTMDRERTLLNLEFKLYAIRHPLKRKRLADLHNMMCLRCSIPEINQLFTEPIKRGATARLADSLALGGVVDGLALNHLFNPEKLDEQELIRYVKLCLSETLLGLQDKTVPQKDDLIRSMQQPLPHPASRRDTLESSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI3</accession>
    <name>E8WVI3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1372</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579753.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68431">
        <property type="protein sequence ID" value="ADW68431"/>
        <property type="gene ID" value="AciX9_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1372"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_23_0_0"/>
    <dbReference type="OMA" id="PMMTSQV"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="17011" checksum="C969CBC4A69B1E8F" modified="2011-04-05" version="1">MFDEVSLGAPENAVGFVMWRIVAHYQREVDRALTLDNLTNLQFITLSLVAWFGREGTPVTQIELARSAGIHPMQVSQTLKLLETKKMISRRISKSDTRAKRVEVTKTGLDALHQALPKVIAVQRSLFGKAGRPGGSLLKELLRIDKALIDPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL7</accession>
    <name>E8WVL7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2514</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580861.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2514"/>
    <dbReference type="EnsemblBacteria" id="ADW69546">
        <property type="protein sequence ID" value="ADW69546"/>
        <property type="gene ID" value="AciX9_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2514"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_0"/>
    <dbReference type="OMA" id="YTHITQS"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="182"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="381" mass="43982" checksum="84531A569EAAA3BA" modified="2011-04-05" version="1">MKSRAYYQFGSLTLKKREKSADVWEFRYYEDAATGGRTRKALFVGTTDKYKTEAQARKAVEAILLKLNAEKPMHHLGTVTFGGLCDRYIAEELPERYSTRKSYLSNINLHIKPRWGEYLIEAVRPMAVEGWFKEMDKSPKTKAHIRSVMHVIFECAARWELFNERRNPIEMVRVKDSTKRRKRPMILTNDTFDAVLAGLPEPFRTMVVVAQCLGLRVSEITGLQWGDLDTERRQLLVQRSIVNGRVDDVKTEYSHDHVPIHESLLEVLLAWSEQCPETEEGWMFPNPLSSKPYYSTEIQKRYLKPAGIKLGLGPIGWHTFRHTYRSWLDETGAPMKVQQELMRHASIQTTMNVYGQAMPESKREANGKVVTMVLKPLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM7</accession>
    <name>E8WVM7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucan phosphorylase</fullName>
            <ecNumber evidence="6">2.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2526</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2526"/>
    <dbReference type="EnsemblBacteria" id="ADW69556">
        <property type="protein sequence ID" value="ADW69556"/>
        <property type="gene ID" value="AciX9_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2526"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_0_0_0"/>
    <dbReference type="OMA" id="LYRHGYF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="5">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="846" mass="95062" checksum="870542894BD0E0A6" modified="2011-04-05" version="1">MSDLKSSKPDKKAAGVNAAPALGIDALKELALNLHWSWNHMADPLWEALDSYLWHSTQNPWVILQTVSDDRVKVLLGTPEFQERLSDLLQHKRKFFSADAWFQKTHPKISLTTIAYFSMEFMLTEALPIYSGGLGNVAGDQMKAASDLGVPVVGVGLLWGQGYFRQDFDADGNQRALYPVNDPGQMPVQPLRRANGEWLRIQIQLPGAMIWLRCWQVLAGRTKLFLLDANDFANSAAHRGITSELYGGDAEMRLKQEIVLGIGGWRLLRELGLSPEVCHLNEGHAAFAVLERARYYMADHRVSLDVALTITRAGNLFTTHTAVPAGFDRFAPELCWKYLGHYAKDELAISMEELLSLGRQNPADASEPFNMAYLALRGSGQVSGVSKLHGEVSRQIFQPLFPRWPQAEVPVGSVTNGIHVPTWDSAEADALWTRACGPDRWRGDRPLADSVRGLTGGELWRMRTSARKTMLAEVRHRYARQLSAKGGPHIDIAELFKEDVLTIGFARRFATYKRPDLLLHDPDRLIRLLTDSRRPVQLILAGKAHPEDIPGQELIKRWNDFIERPEVRSHVVFLSDYDMQMAQELVKGMDLWINTPRRPWEACGTSGMKVLANGGLNISELDGWWAEAYTPEIGWAIGDGKEHGEDPAWDASEVESLYTLLEQQVVPEFYDRDEQGMPARWLDRVRESMATLTPEFSASRAIREYTNDHYLPAAAGYKSRSANDGKLGVNILQWQRRLADHWQTLAFGTVTAETRDGQHWFYIPVVSGGLRPDEFRVELYAAPTEESGDKPEIMAVCKSSADSSGILIYSVCCLAKRPVEDYTARLIPSHPEAFVPLETGQIIWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVM9</accession>
    <name>E8WVM9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2528</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580873.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2528"/>
    <dbReference type="EnsemblBacteria" id="ADW69558">
        <property type="protein sequence ID" value="ADW69558"/>
        <property type="gene ID" value="AciX9_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2528"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_0"/>
    <dbReference type="OMA" id="WAPWYVA"/>
    <dbReference type="OrthoDB" id="953793at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="34199" checksum="5E66FDDEB28E8A9D" modified="2011-04-05" version="1">MKIQSEKFRVEPDKKFRLDDRPTIIKPYCKSKKQYRKTLEDHVEELSSLQQLHYASHRYALLIIFQGIDAAGKDGAIRHVMSGVNPEGCEVFSFKQPSAEELEHDFLWRTTCRLPERGRIGIFNRSYYEEVLVVRVHPEILKNEGLSEELRDEKAVWKERYRSIENFESHLHVNGTRVVKIFLHLSQEEQRKRFLERIDEPDKNWKFSITDIHERKYWKQYAAAFEECLNATSTEASPWFVVPADDKENARLIISRIVMDALKDLKMSYPKTTAKRKAELQAIRKLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP8</accession>
    <name>E8WVP8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative circadian clock protein, KaiC</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580892.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2547"/>
    <dbReference type="EnsemblBacteria" id="ADW69577">
        <property type="protein sequence ID" value="ADW69577"/>
        <property type="gene ID" value="AciX9_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2547"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_4_2_0"/>
    <dbReference type="OMA" id="MGSHSIT"/>
    <dbReference type="OrthoDB" id="271085at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="248"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="501" mass="55402" checksum="A23E0E20AC4757A6" modified="2011-04-05" version="1">MNEHKRVKINQLRTGVPGLDEVLGGGLPEFSFNIIAGAPGCGKTTLAHQFIFANATPERPALYFTVLGEPALKMLRYQQQFTFFDATKLNNAVRFVNLSQDLVERGLEGVLAEISKQVEAANPSIVVVDSFRTVLRSEMLEGKNMAVQTFVQQLALLLTSWEATTFLIGEYSELELRDNPVFTVADGLFWLFQQVDRNSVVRKMQIMKLRGQASVPGLHTFRITEAGLQAFSRTLGLVGARKTFSTVKRLSMGIPALDEMMGGGVPEGDSLLIAGSSGTGKSLMATQFLAAGIRAGEPGIAAVFEERPNEYTARASEFGLDLQTALSEGSLEVIYLRPLDLSVDEMMQEILDAVKRTGAKRLVIDSLAGFEMALAPSFRTDFRESLYRMIFALTAIGITILSTLEMPETFTELSFSSYSISFLTDDIIRMRYVEIDGELCQIMMVVKMRRTAHSREIRKYEITTEGVVIGERLKNYVDLITGIPQPLSALSSEDLLLNRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ9</accession>
    <name>E8WVZ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M14 carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0231"/>
    <dbReference type="EnsemblBacteria" id="ADW67305">
        <property type="protein sequence ID" value="ADW67305"/>
        <property type="gene ID" value="AciX9_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0231"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032905_0_0_0"/>
    <dbReference type="OMA" id="SNGADYQ"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="57"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="621" mass="67949" checksum="EA0EB2169077D420" modified="2011-04-05" version="1">MSWMGLGLGVISGVAGGQTVAHESLLGRPAGPTGCHWTAGQQEWLTPSEKGCYATTPDYDETMGYLRRVQGAAPGQVKIEGFGKTGEGRELDVVVVSKDGLFDPAAIHAAKRPIVLVQNSIHAGEMDGKDSCLALLRDMVILKTKAKLLERAVFVFIPMYNADGHERRGAFNRINQDGPAQMGWRGNGTNLNLNRDYLKADTPEAKAFMGMYQRWNPDFFVDDHVTDGADFQYDVTFSIDDGPNVPKATAAWADKVGPEIVRYIDGHGHVGLDTYVELLDEKDLRKGIAIYDDPPRFSTGYVTLTGRPAMLIELHMLKDYKVRVEGNYEALVGLLEIVNRDADKLLALNAAADEENTRWAGKVYPLAIGASGKTEPIAFKGYAYKTAKSEVSGGDWVQYSHVEETMTIPQQVGYKVEASAVAPVAYIVPRQWVDVIDRLAAHGVAMERTTAAWTAAVDTYKCSGMQWQEPPFEGRHPTFNGEASRNPGKYGECVTVKETRTFPAGSAVVKIDQRLAPVAMSWLEPAGPDSALQWGLFDSIFEQKEYGEAYVVERLAREMMAADPKLKAEFEAKVAADPVFAKSAAARLDFFYQRSEFGKANGVGAYPVGRLDSLAGVPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW16</accession>
    <name>E8WW16_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">AciX9_0248</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0248"/>
    <dbReference type="EnsemblBacteria" id="ADW67322">
        <property type="protein sequence ID" value="ADW67322"/>
        <property type="gene ID" value="AciX9_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0248"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146668_0_0_0"/>
    <dbReference type="OMA" id="WRLVSFD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="146" mass="16410" checksum="5CDA66FC64E20C60" modified="2011-04-05" version="1">MSTSTSHFPDVNVWVALAHERHTHHRVASEWIDSVGPRSALYFCRISQLGLLRTLTTGGAMGGDVLTQAQAWMTYDSFLEDSRNRFMDEPAGIEQEFRERTFRDEASNKLWADAYFATFAQLAGLKLVTFDKALAKSVPGALLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW52</accession>
    <name>E8WW52_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0286</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578686.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0286"/>
    <dbReference type="EnsemblBacteria" id="ADW67358">
        <property type="protein sequence ID" value="ADW67358"/>
        <property type="gene ID" value="AciX9_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0286"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041001_0_0_0"/>
    <dbReference type="OMA" id="HICFCHN"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="382" mass="42264" checksum="38AAA18CDA0F70E2" modified="2011-04-05" version="1">MRVAIVHHWFVTRGGGERVAERFLLLFPQAELFTLVASPEGLPRGAVGHKLHTSFLQRLPFARTHHRHMLPLYPAATESLDLRGFDLVLTSDAGPIKGVRLSPGAVQICYCHSPMRYLYDSYEQYLASMTGLTRLFFRLAAGRVRAWDLKSAAKVTHFVANSRYVAERIRRTYHRESTVIHPPIDLYLARKATPGDHYLCAGRLVPYKCTELAIEACAALNRPLRIAGTGPEEPRLRKLAAALNAPVVFLGELTTDALWNEYAHCRALLFSADEDFGMVPLEAQACGRPVICFGAGGSLETVRGTGPKPTGVYFPEQTSAAMQQAIQHFEANEATFSPQTAKAWAETFATPIFLARIRAFVLRHVPAAAEAMLPFPAIQEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW55</accession>
    <name>E8WW55_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">AciX9_0289</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578689.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0289"/>
    <dbReference type="EnsemblBacteria" id="ADW67361">
        <property type="protein sequence ID" value="ADW67361"/>
        <property type="gene ID" value="AciX9_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0289"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="477" mass="50058" checksum="E07BBF18F74CBD4D" modified="2011-04-05" version="1">MVSIEEARAIRQGSSATALAERHYDRIAANDGIAGKAINSFLSLSRDRAMAQAAHIDALAAKGEPLPPLAGMPIGIKDVLAMQGAPATAGSKILEGYRPPYDATVVQKLEAAGAVLLGKLNCDEFAMGSSNENSAYGPVKNPRALDHVPGGSSGGSAAAVAAGFCVASLGTDTGGSIRQPAAFCGVVGILPTYGRVSRFGLIAFASSLDRVGPLAANVTDAATVLGIIAGHDPLDATSSVRPVDDYAAALTQPIAGLRVGVPDEYFGEGLDTEIRAAVERTLEGLKRQGCEIVKITLPHTKYAVPTYYVIATAEASSNLSRFDGVRFGLRSAESKTLSNMYRKTREEGFGPEVKRRILLGTYALSAGYYDAYYKKAQQVRTLLARDFLTAFESCDVIVGPMTPTPPFKLGEKTDDPVSMYLADIYTVAASLAGICGMSVPCGETSGGLPIGVQIMGRHFDESTMLRIGLAVENQQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW98</accession>
    <name>E8WW98_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68481">
        <property type="protein sequence ID" value="ADW68481"/>
        <property type="gene ID" value="AciX9_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1423"/>
    <dbReference type="HOGENOM" id="CLU_3310496_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="39" mass="3786" checksum="72DBF463C8D7C216" modified="2011-04-05" version="1">MPGAKARVFAGALDVGLKPHSNPNSNSNSSGNGNDSGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWA9</accession>
    <name>E8WWA9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway VirB3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1435</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579814.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68492">
        <property type="protein sequence ID" value="ADW68492"/>
        <property type="gene ID" value="AciX9_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1435"/>
    <dbReference type="eggNOG" id="ENOG50342K3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2478980_0_0_0"/>
    <dbReference type="OMA" id="LAMISFP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007792">
        <property type="entry name" value="T4SS_VirB3/TrbD/AvhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05101">
        <property type="entry name" value="VirB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9941" checksum="79E3056E0942B951" modified="2011-04-05" version="1">MTKRGEPLPINQALNRPRAKLGLDLSAWMAIVFVTVTVFLVGFRMLAILSFPMMAGGAWLIVRKHPKMFQLWGLSLGQKSYYDPRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF9</accession>
    <name>E8WWF9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2598</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580938.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2598"/>
    <dbReference type="EnsemblBacteria" id="ADW69623">
        <property type="protein sequence ID" value="ADW69623"/>
        <property type="gene ID" value="AciX9_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2598"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_0"/>
    <dbReference type="OMA" id="YLPMNAT"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="23473" checksum="47705C98178A761E" modified="2011-04-05" version="1">MITEAVQKSVARIGLVATGPLRLLGLQAIMAARTDLEVIPLSVPRALDTEGLEMVVIDSAVTEHLFELLAAFRRDRPQLRLIVMGAEKDFDYIERVIGAGAKGYLSQSASEDELRMALDVVRDGSVWAPRKVLARLLERAREDSVLRATLPPVFTKREKEVLGLLAKGHPNREIASALGVDEGSIKAHVGRLMRKVGVENRTALAMKTVEIPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI7</accession>
    <name>E8WWI7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2626</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580966.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2626"/>
    <dbReference type="EnsemblBacteria" id="ADW69651">
        <property type="protein sequence ID" value="ADW69651"/>
        <property type="gene ID" value="AciX9_2626"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2626"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_0_1_0"/>
    <dbReference type="OMA" id="DCIHPKK"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9269" checksum="5B942BE3C085DF89" modified="2011-04-05" version="1">MAYVIAEPCIGTKDSACVDACPVDCIHPKKDENGYSDATQLFIDPVECIDCGACVPVCPVSAIYAGDDLPEKWAEYQDKNAAHFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK2</accession>
    <name>E8WWK2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2641</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580981.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2641"/>
    <dbReference type="EnsemblBacteria" id="ADW69666">
        <property type="protein sequence ID" value="ADW69666"/>
        <property type="gene ID" value="AciX9_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2641"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255095_0_0_0"/>
    <dbReference type="OMA" id="DFQNSYA"/>
    <dbReference type="OrthoDB" id="15133at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1496" mass="156120" checksum="2B658A6FAE9C4AA6" modified="2011-04-05" version="1">MSEFDQPAGEPEELQSPSKRKSLAGRFGRGLAWLVGGSLLFLILLLAGAAYYTTTADFQRRVGKEVVSVLEDSTGGRVDLGRITFNLWQLAIEADGLVIHGLEGPGEAPYLSADKILVRVKIFDFLKRTTGTGKRTYVGLNLLRIEQPHVHLIIDKDGKTNQPVPKHTTPSNEPVIDTLLDLKAQKVELVNGLAALNDKAIPFNLAAKDLQAEVHYIASSDRYGATIDLNDLVTEMQKEPEAQSKLHLVAEIGRDAADLKEFSFHTGATSDLTATASLKNFSSPEWSTKLDGSLELKQIQVLSGVDGLDAGSVELHIAGHNCYVAPTVAQKQPTSLFHRLRSKHEAVAAAPKTLPPDPDCQKGYLLVGSAKLHNAGYRDQYVKLHDINGGADLHITPTQLLFTALTGYLPGGGSAKGELKINNWLGEVPANTPTSSPTVAGATTTANKTSAAIVGQPVVSASPTVAPVAAAQAYLTVVVDKISLNTITAVTASKQYEKLGFDTSISGPVTVEWGGPATDIADTVVVDADLKLGPVGAHRGRDIPVTGQVLGHYDGKSETVLLKRLVANTPQSTLTATGILGVNVGDPLTALNVDLSVRDLGEYDTLLKTLGLSGNGKTGSAAIPVTLHGTAAFHGTARGAIAKLDVKGHLEANDLEVRLGDFQAAVTPPPVKPNLITAALSSGSAPAPPPASSQSTDVHIDSLVADAEYTPAGLAVASSTIKQGTAVLNVAGSFKPRTVYKRRVATYVWDDGTTVDVKVQLGNAQVGDVLAIAGQQQKIPVTGTIQVNAHAVGTLKTLAGGGSVSLVNGVAYGEPYESVNVDATVQGKQIEASRVQLKLHGMTIGGNGGYNMASQQLHAHIAGDNLVLSKFKLVQDAKVNADGTLSIVADANGTVEQPGLKASVKLANLVVSGAAIGQAAIDAHSEGKVVYYTANSTLVGATITANGQTELTGNFETKAHLTMAGLDVAKPLELFQPGGLKATSNIAGTIDVSGPAKLPMQLTGRAVFSPLSVTSQGLTFQAAEPLAIGLKNGLATLDAVHITGPDTDLKASGTAQVFGAVNPKTKQPDSSSGKLDVQTEGSVSMALVHTLDPDLITSGKTTFAIGAGGTIGDPQLTGKVQFVAVNAAVNGVPNGLTNMNGTLIFNEDRLNVQSLTATTGGGQLSIGGFLTYRNGLYADLTATGKTVRVRYNGLSSTADLNLKLQGGPQSARLSGSVLITRFGVGADVDFAAFAGSGGVSAPPDPSAASNKIQLDVHITSSPQLDFQNSYAKLAGTVDLTVRGTVADPTVLGKVQITDGSATFAGTNYQLQRGTIYFSNPVRIDPTIDLDVTARVETYDVTVGLHGTASNLKPTYRSEPPLTEADIFSLLALGRTQEEASLYSQQQQQAGTDPTTSSILGGALNATVSSRVSKLFGVGSVKIDPSYVGALGNSSARITVQQQLSRQLSLTYATNVNSSAEQLIQLQYDLTPTQSVVVTRDESDVFSIVFKIHKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM6</accession>
    <name>E8WWM6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3771</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3771"/>
    <dbReference type="EnsemblBacteria" id="ADW70771">
        <property type="protein sequence ID" value="ADW70771"/>
        <property type="gene ID" value="AciX9_3771"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3771"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_2_0"/>
    <dbReference type="OMA" id="HCIDNGV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230002" evidence="1">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="80"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="454" mass="48221" checksum="928DC28E6AF24BDC" modified="2011-04-05" version="1">MRPKLARIASVAAFSLTIAASAQTAPRTLVRTGHLLNVHTGAEPEGLTIVVTGDKITAISPTAQTPAQAGDRELDLTKYTVLPGMFDVHVHLTGTTNFDPYFELSMTPGKEAIIGVENAKTTLEAGFTSVRNVGANDYTDVALRDEINLGHIPGPHMQVSGPALGITGGHMDENLLPFEYHVTGQGVADGIPAVQQKVRQNIKYGADLIKIGASGGVLSKGDDPQASQYTLEEMQAICADAHRLGRKVAAHAHGAQAIALATQAGVDSIEHGSYIDDASIKLMKQHGTYLVPTSYLYDWYKENGKLPAFYAQKMHDVTSVARANHKRAIAAGVKVAMGTDAAVYPHGLNAHEFEVYVRDYGMSPLASLQTGTLNAADLMGWTDKAGSIDVGKWADVIAVEGDPLKDIRLLQHVNFVMKSGVVYKDESAPAAVEKLNPMAGNTLPGAMVVSVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN8</accession>
    <name>E8WWN8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3783</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582091.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3783"/>
    <dbReference type="EnsemblBacteria" id="ADW70783">
        <property type="protein sequence ID" value="ADW70783"/>
        <property type="gene ID" value="AciX9_3783"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3783"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2081499_0_0_0"/>
    <dbReference type="OMA" id="YTEANTQ"/>
    <dbReference type="OrthoDB" id="2064614at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="13235" checksum="DF42E8417B0C7A36" modified="2011-04-05" version="1">MPSLTEAQREKVLPILAAVRTALQEAAEGDLDVLHQMRRYVGKRLEFDERGTPTQRRKLHELKWKSQQGICALCPEPLPERGAELDRLVATAGYTEENTRLVHHACHLKITRAQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP6</accession>
    <name>E8WWP6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0302</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578702.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0302"/>
    <dbReference type="EnsemblBacteria" id="ADW67374">
        <property type="protein sequence ID" value="ADW67374"/>
        <property type="gene ID" value="AciX9_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0302"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_5_2_0"/>
    <dbReference type="OMA" id="NMVEYYL"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="28629" checksum="90D94E4FDA4F6548" modified="2011-04-05" version="1">MATLAVTHSVVATERTFGGTVQIFVKEAKYEFLKLARTKTFSLSTIGFPVMFYVLFGLSNKGHEMDGMDAAKYMLASYAAFGVIGAALFGVGVGMASERALGWLELKRSSPMPAMAYLVSKCISAQAFGLIIVSLLMGLAVAFGGVHLTGREVVMVLGMTVAGSIPFAALGLLIALLVPPNAASGVINLIYLPMSFMSGLWIPIQYLPKFLRPIAPYLPACHLSQLMETIFGYQQIGSTAGHWEGLAGFTLLVLGACWAVFQRAEQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR4</accession>
    <name>E8WWR4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ordered locus">AciX9_0320</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578720.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0320"/>
    <dbReference type="EnsemblBacteria" id="ADW67392">
        <property type="protein sequence ID" value="ADW67392"/>
        <property type="gene ID" value="AciX9_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0320"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_0_0"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="24413" checksum="EE2BFF641B610936" modified="2011-04-05" version="1">MASQKFEAVVATPRTGKFNKNHARRVRVAGKIPATVYGAGIDAVAVTVDPKVVTKILHSESGHNTIFDLNVEGAPLAKAMIVDWQHEPIKGKLLHADFKRIAMDKAMRVSVPVLLSGIPVGVKTGGGVLDQIMREVEIECLPSDIPDHIDVDVANLELYGAIHISDLPHSGSIKFLGDETALVAHVTLIKEEVEPDAAVAPAAEPEVAKKGKGDAAAAAAPAADAKAAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY3</accession>
    <name>E8WWY3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter PnuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1491</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579864.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1491"/>
    <dbReference type="EnsemblBacteria" id="ADW68544">
        <property type="protein sequence ID" value="ADW68544"/>
        <property type="gene ID" value="AciX9_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1491"/>
    <dbReference type="eggNOG" id="COG3201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076589_2_0_0"/>
    <dbReference type="OMA" id="WPDAYIF"/>
    <dbReference type="OrthoDB" id="1301128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23622" checksum="2E83EB2031ECEDCB" modified="2011-04-05" version="1">MSADVLGGHFLNALRAEIFTSPLESVATLLGIANITLLIRRSIWNYPVGICMVSIYAYVFFGAKLYSDVLLQVFFFVVQIVGWVAWLRHQEPDGEVIVETSRARDLVLALLATGLGAALLGYAMGRWAHAAFPYWDATVASASVIAQLLLTWRRVENWVWWIGSNVISIVIYARKGLFLTSGLYAFFLAMAVIGLVSWLKSLRRQRLYTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX41</accession>
    <name>E8WX41_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2658</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580998.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2658"/>
    <dbReference type="EnsemblBacteria" id="ADW69683">
        <property type="protein sequence ID" value="ADW69683"/>
        <property type="gene ID" value="AciX9_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2658"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_0_2_0"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="158"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="17297" checksum="0DE41E161821FD0B" modified="2011-04-05" version="1">MAKGVNKVFLLGNVGKDPEIRSTAGGMTVASFSLATADRQKDAQGNWADKTEWHNIVCFQRTAEVVRDYVKKGSQILIEGKIQTRSWDDKTSGEKKYKTEILCNELTLLGGKAGGESGGGSSSYSGSSSRSSAASSSGGYDQRQPAGTPDYGDSGITDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX73</accession>
    <name>E8WX73_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ordered locus">AciX9_2691</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581030.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2691"/>
    <dbReference type="EnsemblBacteria" id="ADW69715">
        <property type="protein sequence ID" value="ADW69715"/>
        <property type="gene ID" value="AciX9_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2691"/>
    <dbReference type="eggNOG" id="COG1274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_0"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="OrthoDB" id="267285at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="253"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="280"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="527"/>
            <end position="530"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="617" mass="69023" checksum="F8F3C292FCC50546" modified="2011-04-05" version="1">MTPQTSATRSTVLDPTATPPTTNKHLIRWVEKMADLCQPARVHWLDGSQAEYDWLCNQLVEGGTFTRLSEEKWPGCFYARSSPNDVARVEDRTFICSLSKENAGPTNNWEDPFVMRKKLKGLFKGSMRGRTMYVMPFSMGPIGSPMSQIGVQLTDSAYAVVNMRIMARIGAPVYKEIDKDEKRVVPCLHSVGAPLLPGQKDVSWPQNDTKYIVHFPETREIWSYGSGYGGNALLGKKCFALRIASNIARDEGWMAEHMLIVGVESPTKEKTYVAAAFPSACGKTNFAMMIPPAGFDGWKVWTVGDDIAWIKPDATGELRAINPESGFFGVAPGTSARTNPNAMATLRANSIFTNVALTTTNGVPDGGIWWEGMTDEPPAEAIDWRGNPWTPASPTPAAHPNGRFTAPASQCPTIDPSWEDPNGVPISAFLFGGRRPTTMPLVFQAFNWSSGVYIGATMGSETTAAAGGAIGKVRRDPMAMLPFCGYHMGDYFRHWLRMQRNLNSTPRVFHVNWFRKGADGKFLWPGYSENMRVLKWVVDRVRGRVRGKETPIGWTPKFNDMHWEGMDFTYDQFKELQTVDRESWKVEVMGHEELFLALHDHLPPEMIYERELLICRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG0</accession>
    <name>E8WXG0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0421</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578821.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67493">
        <property type="protein sequence ID" value="ADW67493"/>
        <property type="gene ID" value="AciX9_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0421"/>
    <dbReference type="HOGENOM" id="CLU_2935050_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6378" checksum="5CDCCB89442ABACC" modified="2011-04-05" version="1">MTNPEHQPQFNLEEDAKLNALREAILKGDASGIATGDVFAGVLASLHLQDHLDSHGSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM8</accession>
    <name>E8WXM8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ordered locus">AciX9_1591</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1591"/>
    <dbReference type="EnsemblBacteria" id="ADW68644">
        <property type="protein sequence ID" value="ADW68644"/>
        <property type="gene ID" value="AciX9_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1591"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_1_0_0"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="OrthoDB" id="1311145at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="36457" checksum="31633AB51E4E77DD" modified="2011-04-05" version="1">MTASTLDHVSNDQGADQAPVTKRVLLLKPRGFCAGVVRAIDIVQIALEAFGAPIYVRKEIVHNSYVVNDLATKGAIFVNELDEVPEGARVIYSAHGVSPAVREAAKARGLKVVDATCPLVTKVHVEAIKFAKQGYSLVLVGHRDHEEVEGTQGEAPDVTQVVSTLEEVEALVVPDPDKVAYLTQTTLSLDEARYMIEALKVKFPNIVGPHAQDICYATENRQVAVKNVAHGADLVLVVGSRNSSNSNRLVEVSKNLDTNSYLIDSADAIQPEWLNGVKTVAVTAGASAPEVLVKDVVEYLQAQGFGDVDEVEVMPENVRFGLPPEIVQAIASAPKPAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP5</accession>
    <name>E8WXP5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNARE associated Golgi protein-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579980.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1608"/>
    <dbReference type="EnsemblBacteria" id="ADW68661">
        <property type="protein sequence ID" value="ADW68661"/>
        <property type="gene ID" value="AciX9_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1608"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_1_2_0"/>
    <dbReference type="OMA" id="SNARFQF"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="22694" checksum="50D2B45441F67DD0" modified="2011-04-05" version="1">MSEKIIALLIAAIAAGGYASVVLLMALQSACVPIPSEVIMPFAGYALAHSQMDLIILATLASFASNLGSIPAYWAGAKGGRPMVEKYGSYVLLSHHDLDLVDGFFVRFGSMAVLIGRMLPIVRTFIAFPAGVAKMNQFRFHLYTFIGSWPWCYALAYIGMKLGRQFETNPAFKSAFHRFHLGVEAFLLVGIIWFVASHWKNRIRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP8</accession>
    <name>E8WXP8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1611</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1611"/>
    <dbReference type="EnsemblBacteria" id="ADW68664">
        <property type="protein sequence ID" value="ADW68664"/>
        <property type="gene ID" value="AciX9_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1611"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085731_0_0_0"/>
    <dbReference type="OMA" id="IWIAPIM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="287" mass="28262" checksum="D53A969179AF7425" modified="2011-04-05" version="1">MTKSVWMHGSVGLKFAAVCLLSGTMMMEVGCTKKAPAPVGIRNLDGSITNPDGSITYPAGVTPPASSGVAPAPNQAVTVPPGTVPTPAPAPASQQPAPAAMTPGPAMTAGPAMAMTPEAPPPPVRLTVPAGTPVTVRLNGGLAASRNEVGDRWNGVLERPLVYHGQTVFASGTPVSGEVVAAKGKGRFKGAGDLGIELTAIGRDHVSSSEYEKVSPGRGKRTAGFIGGGGGLGAIIGGLAGGGKGALIGGLAGAGAGTAAGAYTGNRDVVIASESVITFRLRSSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY20</accession>
    <name>E8WY20_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC domain protein dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0487</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578887.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0487"/>
    <dbReference type="EnsemblBacteria" id="ADW67559">
        <property type="protein sequence ID" value="ADW67559"/>
        <property type="gene ID" value="AciX9_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0487"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_3_3_0"/>
    <dbReference type="OrthoDB" id="1563802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="15263" checksum="1FE2DF5D4A21E584" modified="2011-04-05" version="1">MNLYRWPDIHLGLAHSFEAVFTEQMTKNFAELSGDINPLHVDAEYAAAAGFASPVIFGLMSSALYSQLAGVYLPGKYALLQGIDLDFNAPCFVGEVLTVKGEVTFMTEAYHRFEAKASIRKKDGKLVSKATLRIGFHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY23</accession>
    <name>E8WY23_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0490</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67562">
        <property type="protein sequence ID" value="ADW67562"/>
        <property type="gene ID" value="AciX9_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0490"/>
    <dbReference type="HOGENOM" id="CLU_2478982_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9866" checksum="F03B301909395CC4" modified="2011-04-05" version="1">MAEDQYSVRFGYRKAPVGFYVVASVDRWGETPVFIRGKRFLRLDQLIKDVPSVYALTRPGRMETSPVRVSDLVLLSLGFDPLAFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY35</accession>
    <name>E8WY35_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0502</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578902.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0502"/>
    <dbReference type="EnsemblBacteria" id="ADW67574">
        <property type="protein sequence ID" value="ADW67574"/>
        <property type="gene ID" value="AciX9_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0502"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050368_0_0_0"/>
    <dbReference type="OMA" id="GGARWHP"/>
    <dbReference type="OrthoDB" id="1249246at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="35075" checksum="ACD408B515F85919" modified="2011-04-05" version="1">MTRYTRQDVLRILHLKTRQLTAWERAGLIASHPENERAYSFEHLSQLRALREMRTGGARRVSAKSMLASMEAMQKVVGMRNVLTETSAVRHGSRLAFRHGGALVDPMTQQLAFDFEGMQGQLKVVNAAPVAGSAAYRAKASAEVQEMFLRGVQLEENAATVNEAMRVYESLLELKPDHAPACINLGTIFYNRKDFDGAERMYRRATEADSQYALAFFDLGNVLDEMLRLDEAIEAYGRAIELVPSYADAHYNLALAYERSGEKRRALRHWMAYVRLDPVGPWGTHAKGQARKILSMERLSIVSRGGRKVAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU5</accession>
    <name>E8WYU5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1733</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580100.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1733"/>
    <dbReference type="EnsemblBacteria" id="ADW68781">
        <property type="protein sequence ID" value="ADW68781"/>
        <property type="gene ID" value="AciX9_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1733"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_3_0"/>
    <dbReference type="OMA" id="WLFQIAN"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21910" checksum="FB32CDA3DC409B65" modified="2011-04-05" version="1">MHVLHKEVTPPQPSVEPVSTLAALLDQRRHFLRFLQRRVSSPALAEDILQNAYLRALEHSAELRSNESSTAWFYRILRNAVIDHYRHRTVEDRAFNQWAAELETEIAPNDLTHDLVCQCIARALPSLTPSYAQILNEVDLAEYSLATFARAHNITQQNATVRIHRARKALKQRLIETCGACSAHGCLDCNCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ21</accession>
    <name>E8WZ21_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2913</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581251.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2913"/>
    <dbReference type="EnsemblBacteria" id="ADW69936">
        <property type="protein sequence ID" value="ADW69936"/>
        <property type="gene ID" value="AciX9_2913"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2913"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_0"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="29366" checksum="DC61138FC79DE78E" modified="2011-04-05" version="1">MIVVTGATGKLGRHVIESLLKTTPAAEIVAAVRSPEKASDLAALGITLRQADYSQPATLLTAFAGADNLLLISGNELGQRIPQHKAVIDAARSAGIKLLAYTSLLRAGTSTLTLASEHLATEQYLQASGIPYVFLRNGWYLENHTEQLAPALAHGAILGAAGEGKFSAASRADYAAAAAAVLTTPGHENKTYELAGDTPYTLPELAAEVAKQSGKPVVYNNLPGPDLEKLYLSFGLPAPVAAMLVDSDLGAAKGELATTSTDLRTLIGRPTTTLAQAVAEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE0</accession>
    <name>E8WZE0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580147.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1780"/>
    <dbReference type="EnsemblBacteria" id="ADW68828">
        <property type="protein sequence ID" value="ADW68828"/>
        <property type="gene ID" value="AciX9_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1780"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_35_2_0"/>
    <dbReference type="OMA" id="GVSRHYD"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="16828" checksum="CC5287E7AAFC464D" modified="2011-04-05" version="1">MKSQTNPGDLGCTCYRLRQSARLTTRLYDRHLAPSGLNIGQFGILATLAAMHGQTISNLAAVLQLDRTTLTRNLLPLQKLGLVEVEPGPDKRARSLSLTQPGREALAQAKPLWQAAQQALEQQLGKPESRHLNQTLDRTLSRLALQEGPQHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF3</accession>
    <name>E8WZF3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1793</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580160.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1793"/>
    <dbReference type="EnsemblBacteria" id="ADW68841">
        <property type="protein sequence ID" value="ADW68841"/>
        <property type="gene ID" value="AciX9_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1793"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="OMA" id="RKEWYAN"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="34125" checksum="7068638818BB6A79" modified="2011-04-05" version="1">MTAFGQAIRRLLVAIPVLWLVVSVVFLLIHLVPGDPIVQMLGEGASAADITAMRHAYGLDATISTQYIRYITGVFRADLGQSLRMHESVIRLVLSRYPYTLTLSFSALLFGCGIAVPCGIASARHAGQWQDRTLGLASFLGLSFPNFALGPILILVFSIQLGLLPVSGAGSGANFMAHLILPTVTLGSGLAAILTRIVRTSMLEELNQDYIRTARAKGVTERSILYRHALRNALNPVLTVIGLQFGSLLAGAIVTETVFSLPGIGRLTLSAISNRDYSLVQGCILAIGLTYIAVNLLTDVAYGIANPQLRRSDSPSHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL1</accession>
    <name>E8WZL1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-like beta Propeller containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2962</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2962"/>
    <dbReference type="MEROPS" id="S09.071"/>
    <dbReference type="EnsemblBacteria" id="ADW69985">
        <property type="protein sequence ID" value="ADW69985"/>
        <property type="gene ID" value="AciX9_2962"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2962"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_2_0"/>
    <dbReference type="OMA" id="NDYAGKE"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233528" evidence="3">
        <location>
            <begin position="21"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="478"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="680" mass="72960" checksum="C12CD1A18351922B" modified="2011-04-05" version="1">MTFYRFLAGALPALALSAFAQSGTPALMTPLAHPDPRLATIHSQMGRAKAPGQVAISPDASTLAYTLRSEGSPIHLTSAVNPDPAKEKLVSPGSSTTCGNYSPVWSPDSQWLAYTSSCTTSQDKPGQDQIFLYSRATGESKQLTHLNGLFQEVAWAPDGKSLAFLFVQDASRSAGALAAMKPWAGVIGEDGVEVQRIYAVDVATGKGSFQSPLTLHVYEFGYSPSSKEITYIAADAPGENNWWVAQLYAAPIKMGQNDVPAQPRGVFDPNTSKSALHGLQIAVPRWSPDGKHIAFIGGLMSDQGSTGGDVWVVDAKGGEATDITPNIDGTPTFLSWTGNDSIGFVEDRSGHTLLTDYTVSTRKQDATQDLGETSIGGGSIKNAISVSTNGTLAFTKAGHDLAPEIWAGPFNAEKQITHLNDGAKPGAHTESVEWENEGFRVQGWLTYPASYDASKKYPLIVTVHGGPSASSGASFGGSVWAQLGYFVFSPNPRGSFGQGEKFTAANIKDFGYGDLRDITSGMDAIEKKVSIDKSREGLMGWSYGGFMTMFGVTQTHRFKAAVAGAGISDWKSYYGENSIDQWMVPFFGHTVYDDPAVYAKSSAIEYIKQVTTPTLVVVGDRDGECPAPQSFEFWHALRAEGVKTQLVVFPNEGHGFRDPAHIRDLEAREVAWFAENMPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR8</accession>
    <name>E8WZR8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0658</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579057.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0658"/>
    <dbReference type="EnsemblBacteria" id="ADW67729">
        <property type="protein sequence ID" value="ADW67729"/>
        <property type="gene ID" value="AciX9_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0658"/>
    <dbReference type="HOGENOM" id="CLU_952372_0_0_0"/>
    <dbReference type="OMA" id="HVERTIP"/>
    <dbReference type="OrthoDB" id="1602696at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233537" evidence="2">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="32381" checksum="707B16DD54F287A1" modified="2011-04-05" version="1">MKLPLFALVLLTMQAAAPQQQQPAPPRPTQPRMTSSSPLNDSFDELLIRIETTAAQYRSLIPSLTVDETADTWVTPPAAPFKHHVELKSTFRVVRQPNSPNLKESREITQIDGKPYLPEDRARIPMLFDGAFSGGQSLYFRPESRHCLTYIAAPGLTKDKLIQITFYAQKSVDNDPTCSAITPGLKGGARIEPLFLQVVHVERTIPTPIAIQRKTASFSSVDYAPADFGDLSVWLPTLIIASTPDDSRHFAARYSNYHHLTVNSTILPGTITEPEKSEPPKPTPPPLPRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU4</accession>
    <name>E8WZU4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ordered locus">AciX9_0685</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579083.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0685"/>
    <dbReference type="EnsemblBacteria" id="ADW67755">
        <property type="protein sequence ID" value="ADW67755"/>
        <property type="gene ID" value="AciX9_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0685"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_0"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="600" mass="66380" checksum="56D161BC6C1E5F79" modified="2011-04-05" version="1">MDLAHIRNFAIIAHIDHGKSTLSDRLLEITGSLTSREMQAQVLDAMDLERERGITIKAHTVRMNYTAENGETYQLNLIDTPGHVDFSYEVSRSLASCEGALLVVDASQGVEAQTLANAYLAVSNGLEIIPIINKIDLPSADIERTKEMIEKSVGLPADDAVAVSAKTGLNVAAILEAVVHRLPPPLGDPDAPLQALIFDSWFDAYRGVIVLARIINGKLRKGMKIKIMSNGRQFDVESMGVMTPKPVALDELSAGEVGFFVATIKNVADTKVGDTITEVDRPCAEALPGFEDIKSMVFAGLYTVDSHEHAMLRDALEKLRLNDASFSFEPESSVALGFGFRCGFLGLLHLEIIQERLEREYDLDLITTAPGVRYKITLTDGKVLEVDNPSRWPDPTEIEQIEEPVIIAKILTNEEYVGGILKLVEDKRGRQQNMEYVSDTRVLITYELPLNEIVLDFYDRLKTVSRGYASLDYQLAGSWVSPMVKMDILIGGDAVDALSIIIHKDFAQTRGRALVSKMRELIPRQMFEVAIQAAIGSKVIARETVTAIRKNVIAKCYGGDISRKRKLLDKQKEGKKRMKRIGKVDIPQEAFLAVLKVGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X023</accession>
    <name>E8X023_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase, family 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1873</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1873"/>
    <dbReference type="EnsemblBacteria" id="ADW68919">
        <property type="protein sequence ID" value="ADW68919"/>
        <property type="gene ID" value="AciX9_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1873"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348038_0_0_0"/>
    <dbReference type="OMA" id="FRNPGFE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="817" mass="87663" checksum="98B26A3F375F0342" modified="2011-04-05" version="1">MKSFQRGTSLRPLKLLLLCPVLLPMLLIGCKAGASKRTEASGQTSEPQPSGPQPSITTITLGPETIRTSVKRMGINLSGQSFYDSGQMLRNLTFRNPGFEGEIWQSILRCKSVTANSCTDENQYTQWPAGFLNGAHFEFISGPAKGESGTLLSSSAATPPLGVTLSFNALPKALAANDFILVRMDKPGHAEAGWWPNLSGGATLSTETKDLAPGTLGRQALSLNASAPLQSAAVSSYFDSFQGHSFVQLHGVYRLQFHAKPTSASHTLDVKLERLDTSRGIESLFSKSIPLVPGWHDYSFDFPTNETGFSVGTVGLTFTAHETSLLLDDVSLTPATHPANNPTAFRDEVVQTLRDLHPGVLRYMDNGTDFGSSLDNMLTPAFGRQRAGASTQSTLAEDIPIGLHEFLVLCQAIGAEPWYAMAPGTSPAESAALVEYLAGPSTTPYGAKRAALGQLKPWTEVFPTIHLELGNEEWNSRSFAGSSIADPTVYGQRAGQVFGAARTSPYFRPGNFDLILGAWSAVPWWTGQELASTSNVDSAAVAPYLFAEFNDGSSPEAIFGPMLAQPEQLDSRPDGAMALQLKAAQSAPHPVHLAVYEVNMGSMTGTASQSEIDESVPSMGGGLAVADHMLLMLRDLGVTTQAFFSLPEFQNDFTAPSGPKRTMPLWGAVVDMGGNTNLRRPQFLALQMLNQAILPNLIAAHLSGPNPTWNQPESNNDKIKLPNAHELQTFAFADGPRRSLILFNLSRTASHPVVFNGANAPSGAVEQTLLTSSRITDSNEILAKVKPVTTQNSHFNPAAPFQLPPFSMTVLTWTAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X033</accession>
    <name>E8X033_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1883</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1883"/>
    <dbReference type="EnsemblBacteria" id="ADW68929">
        <property type="protein sequence ID" value="ADW68929"/>
        <property type="gene ID" value="AciX9_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1883"/>
    <dbReference type="HOGENOM" id="CLU_1956513_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="13851" checksum="FB5F5B2B35886845" modified="2011-04-05" version="1">MLGWPTFPRTSRSLSFIPISTSMISLRLIRLEGACLATALILLLAYLMVARRINLKGLLGSGSGFAGLKLERVLLLVVTVVVSLKYAIDLVTDGSGTMPGIGLWWLILFGASCAVYLIGTWLRVARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B3</accession>
    <name>E8X0B3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3074</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3074"/>
    <dbReference type="EnsemblBacteria" id="ADW70094">
        <property type="protein sequence ID" value="ADW70094"/>
        <property type="gene ID" value="AciX9_3074"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3074"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_2_0"/>
    <dbReference type="OMA" id="NPRICRV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="30611" checksum="68DE7E6DFBC05896" modified="2011-04-05" version="1">MHIKIKSPWLIKPDTKVKLSKLETKADGGFNSPEAAAAVLVKHQRKLQKLQEVLYASQQRSVLIVLQGMDTAGKDGTISHIFEGINPQGCDVASFKVPTPLEARHDFLWRCHAKAPAKGMIVVFNRSHYEQVLSPQVHGHLSGKEVKESLAQINQFEQMLADQGTLILKFFLNISREEQTARLKARIDDPKKHWKLSAGDFAERKFWPQYADAYEDILSETSKKHAPWFAIPANHKWYRNLAISEVLEQAFEGMKLEYPKPTVDASTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D0</accession>
    <name>E8X0D0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recG</name>
        <name evidence="10" type="ordered locus">AciX9_0724</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0724"/>
    <dbReference type="EnsemblBacteria" id="ADW67794">
        <property type="protein sequence ID" value="ADW67794"/>
        <property type="gene ID" value="AciX9_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0724"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_0"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="318"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="553"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="779" mass="86527" checksum="22C806DCC4A901E3" modified="2011-04-05" version="1">MSLKLSTPIQFVKRVGDRVAENLARRGVETVEDLLYHLPFRYEDRLNPKPLDQMKPGEMASLLGDVRGSTLLTTRGPAIFELTLGLVPLGAEGLGFGGRISQPTIKCLWFNGTYLRERFRLGQQVAVYGKLEASRSGGSGRFKLIQPQFEILPGPGASGPDAEFAALEMGRIVPVYESLGGTTPWGAKLTSKWTRRVMWSVFEELIESGAEIEETLPAPLRERLALPNRLEALKSIHFPEAGTPVADLMTARTPGHKRLIFEEFFYLELGLELKRRKLRERIGTRFETTDQVRAAIRQVLPFHPTTAQKRVLAEIVGDMKKDQPMRRLLQGDVGSGKTIVAMQAALVAIENGFQAALMAPTEILATQHYLSARKLLADKLSPLTGKPYRVTLLTGSLDLDRKRESRGRIMRGEAHLAIGTHALIEEKVDFANLGLVIVDEQHRFGVQQRFKLMKKPNAEGVMADPDVLVMTATPIPRTLALTIYGDMDVSVIDELPPGRTPIVTRRTSEASSAKVWEFVRKQVALGHQAYIVYPIIEGANDDQPELDFAPEPSAQDEPTPTKGKRGKKTESLFPKAKLRSATQSFDELRAGPLQGLRVGLLHGRMSADDKEVAMRRFQRGETDVLIATTVIEVGVDVPNASVMVIDHAERFGLAQMHQLRGRVGRGAAKSYCILMTGDKVSESAELRLDAMVHTQNGFELAELDLAQRGPGEFFGTRQAGMPEFRVADLGRDREVLEIAKSEAARFAQSPDPTLTPEQITEVWDRLKQQWQRRYALVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D7</accession>
    <name>E8X0D7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase I</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">polA</name>
        <name evidence="10" type="ordered locus">AciX9_0731</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579127.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0731"/>
    <dbReference type="EnsemblBacteria" id="ADW67801">
        <property type="protein sequence ID" value="ADW67801"/>
        <property type="gene ID" value="AciX9_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0731"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_0"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="8">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="9">
        <location>
            <begin position="733"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="975" mass="106912" checksum="0EBD42715EE33C64" modified="2011-04-05" version="1">MASAQTPGSKPPIYLLDSMAFIFRAYHAMQRQRPMSTRTGIPTAATYVFVNMINKLRKDFAPVYLAAVYDVGAPVHRNELATQLKDVKKFNIKTQQFETTEYGGYKANRVETPPDLIQQQPYIRRALEAFRIPILYYEGFEADDVIGTLSCKLSALGHHVYVVSSDKDMMQLVNDNVSILNPTKDNLILDPAGVEGILGVPPERVIDVMALRGDAIDNIPGAPGIGDKGSVELIQQFGTVEGALDRAEEVKKKTYRESLLNNRENIMLSKELVTIHTGVPIEYSIEAMRTQPVDNAACRELFSELEFTTLLKELAPAVDNTPLAFNLKATEADLTALLAAARETDPETGKVRGFSLAMFEDARALAEETAAEPAENVEEAEPAPAENMSLFGAPADETPAVVEEPKDAACRLGLAVAENAAIEVSIDFAGLRDALEDAALPKDLHDLKAVLRALEPHGITLAGVRDDVMLLSYLVNPTHGSHTLPDVVARFTNRALTPVVKGVVSPTLLPESANAIHRVAPILRKQVEEAGLVVHEIPKDDPALGGAVTHEMLFPPAAAPVVGKADGPLVKVYETIDLPLVPVLLRMEEAGVRIDPAVLNEMSSRLAVEIDNLAEKIYADSGHRFNINSPKQLGDVLFNKMDLPKPMKYGKGKVVSTAQDVLEELAENHPIAALVIEHRQLQKLKSTYLDQLPSLSDREGRIHTTFNQVGTATGRLSSTNPNLQNIPTRTAIGREIRAAFIAAPGNLLMSADYSQIELRLMAHFSQDPLLLNAYRTGQDIHTLTAAEVFGVDAETMDKETRARAKAVNFGIVYGISPFGLAAQLGIDQKVARTYIETYYDRYKGIKRFIDETLETVRLAGAVSTHFGRVRPIPDIQSRNPNMRGFAERTAINTPLQGTAADLIKLAMISLDREIRARGLKSRMTLQVHDELLFDVVPSEAEEMQTLVQHEMENVAEFSIPIVADIGLGDNWRDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E0</accession>
    <name>E8X0E0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0734</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0734"/>
    <dbReference type="EnsemblBacteria" id="ADW67804">
        <property type="protein sequence ID" value="ADW67804"/>
        <property type="gene ID" value="AciX9_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0734"/>
    <dbReference type="eggNOG" id="ENOG50307T3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049428_0_0_0"/>
    <dbReference type="OMA" id="MYVVANG"/>
    <dbReference type="OrthoDB" id="1752332at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4397" evidence="1">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="27048" checksum="11250DFD2AAE4C4B" modified="2011-04-05" version="1">MNSMPHLPRETMTALRSKTLSFRAIPNKRQVLSAVSLAGLVGLPGCSAVTGNPVVSLIRIVDASSNSNGIDVYQGSGALAYNLGLGTITTYVPVTPGTYNINVDAAGGKTQLATVLGSFGPNAQYTVVVGDNSTVLGETVLKDQSVPAPSGQVALRFIHQSSAGGAVDIYLIPNGSTISQVKPILTGVTFGTNTGYLNEPAGTYTLAAVPTGTVPSATTATSYSGNAVVYGSGTAKTIVLINQPLLTTPGIQVVMADDFDPATATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H9</accession>
    <name>E8X0H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="11">3.4.24.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0774</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579169.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0774"/>
    <dbReference type="EnsemblBacteria" id="ADW67843">
        <property type="protein sequence ID" value="ADW67843"/>
        <property type="gene ID" value="AciX9_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0774"/>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_0"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="305005at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230137" evidence="8">
        <location>
            <begin position="19"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13_N" evidence="10">
        <location>
            <begin position="56"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="9">
        <location>
            <begin position="486"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="699" mass="77526" checksum="6929AA125CFC2E85" modified="2011-04-05" version="1">MRIQSVASYLLLSGTLLAGGSALGQNVVSTDDNGPTSAPKKPMSFDLSSIDKTADPCTDFYQYACGNWIKNNPIPPTETRWGSFNTLGEQNQYLLWKELSAAAANPKTPLQTKYGNYYAACMDVKRVNELGVKPIQPELAQIAELTDKKKLAALDVALENTYGSGFLFGVAVGQDQKDSSKQILQTGQGGLTLPDREYYLSDDARNAKIREQYVDHVTKMFVLMGDTPEKAATEAADVMRIETALAKGSMSRTEMRDPAARYHITTIAQLQELSPDFDWHVFLTGVGVAQATTINVSSPGFVKTVNTLVDTESLEALKTYMRWHVLHGAAAYLSEPFVDENFNFFAKTLTGQKEQQPRYKRCTRLTDGALGEAVGQDWVKENFPPDAKANMEKLVAALRKALDQDIQQLPWMSPETKVEAEKKLVAFRQKIGYPETWRDYSKLTVKRDDFVGNLARNSVFERNRNLGRLGKPVDETEWGMTPPTVNAYYNPPQNDINFPAGILQPPFFDNTKDPAVNFGGIGVVIGHEMTHGFDDQGSKYGPTGNVKYNTDGTLGSWFTPEDQKKFDERTKCVADEYSGFNVAEGQNLNGRLTLGENSADNGGIRIAYQALQQVMAKQGISPTSQIDGYTPAQRFFISFGQVWCSNQTEQSARVLAKTDPHSPGKWRTDGTVQNFDEFGKAFSCKVGQPMMPEKSCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K9</accession>
    <name>E8X0K9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1914</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580279.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1914"/>
    <dbReference type="EnsemblBacteria" id="ADW68960">
        <property type="protein sequence ID" value="ADW68960"/>
        <property type="gene ID" value="AciX9_1914"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1914"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155030_0_0_0"/>
    <dbReference type="OMA" id="CAACTSW"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="109" mass="11746" checksum="55A7A0746E89676E" modified="2011-04-05" version="1">MYCPTCGKEIQTQANFCSNCGAALAAQSFAPTGPRILRPRSPRMIAGVCSGFALHFGWDLSLVRILLCVFTFLTSGIGFLFYIAAWVLLPEAPYALPATTDYPNPQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L9</accession>
    <name>E8X0L9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein AciX9_1924</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580289.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1924"/>
    <dbReference type="EnsemblBacteria" id="ADW68970">
        <property type="protein sequence ID" value="ADW68970"/>
        <property type="gene ID" value="AciX9_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1924"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_2_1_0"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="11313" checksum="5EA4D100930EDCEB" modified="2011-04-05" version="1">MDFSDLGKMKDMLAQAGAMQEQMEQKLSETVVEAESGGGVVKVRMNGRKELLRLRIDPAAMGSTAADLELLEDLITAAINEAGRRADEAMKSSVGGMMGGLGLPGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N9</accession>
    <name>E8X0N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1944</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1944"/>
    <dbReference type="EnsemblBacteria" id="ADW68990">
        <property type="protein sequence ID" value="ADW68990"/>
        <property type="gene ID" value="AciX9_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1944"/>
    <dbReference type="HOGENOM" id="CLU_2355771_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="10205" checksum="263A56112ECE21C5" modified="2011-04-05" version="1">MLFSLPLLLLVIAIAECAEQGARGHSGLAHETYYLFLIAYTYYLSGASVGFYAPRLGLPWGTPFIGHFAVSAGCQPYLALPVPVACPTRGVSVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q7</accession>
    <name>E8X0Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1962</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580327.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1962"/>
    <dbReference type="EnsemblBacteria" id="ADW69008">
        <property type="protein sequence ID" value="ADW69008"/>
        <property type="gene ID" value="AciX9_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1962"/>
    <dbReference type="HOGENOM" id="CLU_2788056_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7597" checksum="C6AE9F4D2D0B5E7A" modified="2011-04-05" version="1">MTKVKMTHSAVGAGIHHAAEHVYELPDHVAEQYVNAKLATREEGEPEVAAHTPQEKRDKAVRKPNETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z3</accession>
    <name>E8X0Z3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581490.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3166"/>
    <dbReference type="EnsemblBacteria" id="ADW70177">
        <property type="protein sequence ID" value="ADW70177"/>
        <property type="gene ID" value="AciX9_3166"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3166"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_0"/>
    <dbReference type="OMA" id="AYTGISF"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="304"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="43676" checksum="963684C1EE29BE4D" modified="2011-04-05" version="1">MQDNTQHISTSAVDGKNIAIVGGGPGGLTLARLLQQSGAKVVVYERDQSRSARVQGSALDLHEGSGLAALEAAGLMEAFWANHRPDLDRLRLTDARGTVLHDHVRRMSGDGKRPEIERGPLRDLLLDSLQPETVQWDCKLEYAEMRGDQVLLRFAGGKTALGDIAIGSDGANSRLRNLVTPIQPEYVGVSLVEAMVPAAKQTIPELWSLLGGAALMALGGERTIGMGTKSDGSVLVYAGLKTKDDVLRESLEEATSPDKRVAWFHGNFEGWSKLWEPLFREAVSMVWRPLLTCPSDQRWEPKPNVTLIGDAAHVMPPYAGEGVNMAMLDALVLSKLLLSERSSSEAIAKYEVQMFDRMRHMTADTMANTEMFYAPDAADRVVALFRSFARTEVVQPAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X102</accession>
    <name>E8X102_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0800</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579193.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0800"/>
    <dbReference type="EnsemblBacteria" id="ADW67868">
        <property type="protein sequence ID" value="ADW67868"/>
        <property type="gene ID" value="AciX9_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0800"/>
    <dbReference type="eggNOG" id="ENOG5031DEM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959569_0_0_0"/>
    <dbReference type="OrthoDB" id="1854644at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="37066" checksum="BEB547F75C2FF03E" modified="2011-04-05" version="1">MESQSPFDSRRIKLGLAHDAYKTDTVRIVERDLSGLTHLVSSRQGLWAVNHQECRLIAHGLFFGITITNQTIYLFESCDLPRSPLAMGRLAALTLAHDRIVDVKILAKGLDNGCHQIDFIDGKLQVLDTYNQRILSFATEGEQWTPEEIHPLDRKPTRGWKDDDPSYVHANSLLAVGDRTLLLLHNGGKHLGRNSEIAVFDKQWRELERWPLRGSGCHGLALLEDGTVLTCGSLEGTLLSPDDRIHVHVSPHMTRGLSVGKDSIVVGASRLVEREGRMTNSGTITFMDREFKVAAVLDVPAAPTEVRRLDGQDAGLSPYLATQPWGSKTNAPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X110</accession>
    <name>E8X110_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III Xth</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0808"/>
    <dbReference type="EnsemblBacteria" id="ADW67876">
        <property type="protein sequence ID" value="ADW67876"/>
        <property type="gene ID" value="AciX9_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0808"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_0_1_0"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="28080" checksum="34BFE550BF682285" modified="2011-04-05" version="1">MNSIRARAEHVKRWLAARQPDVLLLQELKGTEFPAEWFMEQGYHSAAVTQKAYNGVAIVSRTPLEVVSTTLAGDPEDSHARFLEAMIDGMRVVNIYLPNGNPVGTPKFEYKLAWMDRLMEQMKVWLGDGVPTVIGGDFNVIPEEIDCHKPASWVHDALFQPESRARYRGMLELGYTDAFRTLHPGLGGQFTFWDYFRQAFESNRGIRIDHFLLTAEMAGRLESCEIDRGPRGEAKPSDHTPIVVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X123</accession>
    <name>E8X123_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579214.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0821"/>
    <dbReference type="EnsemblBacteria" id="ADW67889">
        <property type="protein sequence ID" value="ADW67889"/>
        <property type="gene ID" value="AciX9_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0821"/>
    <dbReference type="eggNOG" id="COG3115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142719_0_0_0"/>
    <dbReference type="OMA" id="WANDSTK"/>
    <dbReference type="OrthoDB" id="1916766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022236">
        <property type="entry name" value="DUF3761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12587">
        <property type="entry name" value="DUF3761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234251" evidence="2">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="171" mass="16408" checksum="E241E438BA1030FF" modified="2011-04-05" version="1">MFKALCAALVMAGLTGVAAAQAPAGAPAGATGICKDGTYSTAPAKSGACAGHKGVQTWYVASAMPAPKPGATSPSLPAPTPVKTAPAAMPAPTPAAAAQSAPKPGPAAAAAAKPQAAGGGHGLVWLNTGSNVYHCYGTEYYGKTKAGAYMSEAEAKGKGAHGVKGATCEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X194</accession>
    <name>E8X194_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2003"/>
    <dbReference type="EnsemblBacteria" id="ADW69048">
        <property type="protein sequence ID" value="ADW69048"/>
        <property type="gene ID" value="AciX9_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2003"/>
    <dbReference type="eggNOG" id="ENOG50347MW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060749_0_0_0"/>
    <dbReference type="OMA" id="YPNSTEH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230550" evidence="1">
        <location>
            <begin position="30"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="28093" checksum="30FA1ECC59F05414" modified="2011-04-05" version="1">MITTLFSPVNLSIAVLCAISSLMSGQSSAINLTENTDIPSRVLKPGLYKISIVDSLDDRYIVRVEYPNSTEHQLFLGVVGSPHPAGVVDWEKGIDGNHAIREVSFENGPVVEFVYPKADAAKLAQKNKSHIVAVDYASANIVHTDRLTADQIRVVDLWTLSFTKTGPEDQTPAILAQRYEPPSTQVTTPNLGVAQVAQLHLPAQPAASPTPPALRPVKHLATIRTLPHTGSQLPLVWLLGALSIVGALSLQFSSNKRGSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X196</accession>
    <name>E8X196_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2005</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69050">
        <property type="protein sequence ID" value="ADW69050"/>
        <property type="gene ID" value="AciX9_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2005"/>
    <dbReference type="HOGENOM" id="CLU_3062062_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="5524" checksum="D22D6FBAF8E779E7" modified="2011-04-05" version="1">MKKLLFWTTVLSGTAAAYLLYKRGVPVGTIASDVLTHPIGTLVHELGAGGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X197</accession>
    <name>E8X197_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2006</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580369.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69051">
        <property type="protein sequence ID" value="ADW69051"/>
        <property type="gene ID" value="AciX9_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2006"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167400_0_0_0"/>
    <dbReference type="OrthoDB" id="895136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12661" checksum="DAD377105EC8CF3D" modified="2011-04-05" version="1">MDEQLKSYTKTLGERIKAARKQRGISNKKLIIDYGIHDSQWRRYERGGGISFASLLRIASVLDMTPSDLLQGIPLPDWKEPTVLRETKEVPRSPRPSELAKRQLQVDRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X253</accession>
    <name>E8X253_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3285"/>
    <dbReference type="EnsemblBacteria" id="ADW70296">
        <property type="protein sequence ID" value="ADW70296"/>
        <property type="gene ID" value="AciX9_3285"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3285"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116201_0_0_0"/>
    <dbReference type="OMA" id="WFFNGVF"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="23391" checksum="BCDB562846D80716" modified="2011-04-05" version="1">MSGRTKTVVMNPAVDAYIDRAKPFAIPILLHLRGLIHKASTEVVEEIKWSRPFFSYKGAILCNISGFTKHCSIGFWGTEIGAVLREAGAVKDEGMGSLGKITSLKDLPRDKVLVGWLKQAMGFVDSGEYTSPIAARRQVVKAAKAEIEVPSDFSEALGKGTKTAGVWAGFSPSCKREYLEWITGAKRAETRAARIVSAVGWIGEGKQRNWKYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X279</accession>
    <name>E8X279_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0944</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579335.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0944"/>
    <dbReference type="EnsemblBacteria" id="ADW68011">
        <property type="protein sequence ID" value="ADW68011"/>
        <property type="gene ID" value="AciX9_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0944"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_5_0"/>
    <dbReference type="OMA" id="LIRKPHG"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="545" mass="61433" checksum="3480FC775F5E6F6A" modified="2011-04-05" version="1">MATPIAIPIPVNDMGLDETERARALAKRYHSEFVDLKNFKIQHELFKSVPVDMMFRYNFVPLEQAGGRLAIAVSDPSKLMVLDEISGLLGTRLVTRVATLSQITDLLKKTEQSQRVLDEASEGLAFDVLSNEENADENISIEKLTADDDISPIIRLVDTTIFTALERRASDIHLETFDDSLLVKYRIDGVLQQAMAPIAREHHQTILSRIKVMSELDIAERRVPQDGRFRVRYKGRLIDFRVSIMPTVHGENAVLRVLDKESMSEKFTKLSLDVVGFAEKDLTRFRRYIKEPYGMVLVTGPTGSGKTTTLYAALNEIKSEEDKIITIEDPVEYQIRGITQIPVNEKKGLTFARGLRSILRHDPDKILVGEIRDAETAQIAINSALTGHLVFTTVHANNVVDVLGRFLNMGVEPYNFVSALNCILAQRLVRQICEFCVREIHYTDAELVENGLVPDEWRGVVFKEGAGCMECSGTGYRGRSAIHELLELDDEIREMLLNKKPGSEIRKKAKDKGMMFLRDSALDRVREGVTTLKEINKVTFIEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F5</accession>
    <name>E8X2F5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ordered locus">AciX9_2135</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580495.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2135"/>
    <dbReference type="EnsemblBacteria" id="ADW69179">
        <property type="protein sequence ID" value="ADW69179"/>
        <property type="gene ID" value="AciX9_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2135"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_1_0"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="9166" checksum="8B41A2BB643E4C7F" modified="2011-04-05" version="1">MIRLARVGATKQPHYRVVVIEKDRARNGRSVEVVGTYNPRTNPATVLLKRDRIDYWTKNGAQLSDRVGKLLAAAPVAVEPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G1</accession>
    <name>E8X2G1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2141</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580501.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2141"/>
    <dbReference type="EnsemblBacteria" id="ADW69185">
        <property type="protein sequence ID" value="ADW69185"/>
        <property type="gene ID" value="AciX9_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2141"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_3_0"/>
    <dbReference type="OMA" id="TRQVFFN"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="156"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="269"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="608" mass="65566" checksum="7F5020DE94239426" modified="2011-04-05" version="1">MATTPTLPTEVTAIPALPAGGSFLITSPTPASCFFPEDFTSEHQQIAEVTADFALNEILPHSEAIEHKDFSITRDLIKKAAELGLTSTDIPEEYGGLEMDKATSAIIADHIAKQGSFSVAISAHTGIGTLPLVWYGTHEQKTKYLTKIADGTIVAAYALSESTSGSDAVNARTRAVLSEDGQHYILNGEKMWITNGGFADLYTVFAKCLIPSGKGAGEEKLTAFLIERGTPGFTNGPEEHKLGIRGSSTTPLILNDCKIPAANLLGEVGKGHHIAFNILNVGRYKLGNAAVGAARHTLGNAIRYARDRKAFGKSISEFGLIQEKLADMAVGIYVGEALCYRTVGLIDQALAQTEKSDTPAIQRAIESYAVECSIVKVWASEMLDFVVDETVQIFAGYGYVEEFPAERAYRDARINRIFEGTNEINRLIITGRLMKAALAGQLPLLPAIKALMDEVLAGPIEKEDREGPLAAECDLLAAAKKLTLFIAGTASQRYMQKLVDEQEVMAAIADMIIQVFAMESAILRTEKLLANSGKGTDTAVTITRIYAAKAMDILESQARKVIAAAAEGDMARTQFTILRRLVKHDPADTISLRRSLAQHIIAAGKYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H0</accession>
    <name>E8X2H0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2150</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580510.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2150"/>
    <dbReference type="EnsemblBacteria" id="ADW69194">
        <property type="protein sequence ID" value="ADW69194"/>
        <property type="gene ID" value="AciX9_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2150"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_4_0_0"/>
    <dbReference type="OMA" id="NFAQMVG"/>
    <dbReference type="OrthoDB" id="1862336at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10703" checksum="960519A52B0424F6" modified="2011-04-05" version="1">MAVLSKAELDELLEKQQGWELQDGKLVREWRFRDFVEAMKFVDFVAEVAEEAGHHPDIDIRYNKVKLGLVTHDEGGISSKDADMAARLGARFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K5</accession>
    <name>E8X2K5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2185</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580545.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2185"/>
    <dbReference type="EnsemblBacteria" id="ADW69229">
        <property type="protein sequence ID" value="ADW69229"/>
        <property type="gene ID" value="AciX9_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2185"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_0"/>
    <dbReference type="OMA" id="QGIRVCT"/>
    <dbReference type="OrthoDB" id="1260864at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="26146" checksum="39F25003AAEE82CA" modified="2011-04-05" version="1">MEIAGKVFLVTGGASGLGEATARMAVGRGAKVVLADVNPKGEALAAELGEGALFVRTDVTSESDGERAVQAARERFGALHVLVNCAGVAPSERVLGRSGLHGLESFARAISINLIGTFNMLRLAAAAMAENEPMGDGERGVIINTASVAAFDGQIGQAAYAASKAGVAGMTLPIARELARVGVRVMAIAPGLFMTPMMAGFSAEVQESLAKSVPFPARLGRPEEYASLVMSICENAMLNGETIRLDGALRMAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N8</accession>
    <name>E8X2N8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3326"/>
    <dbReference type="EnsemblBacteria" id="ADW70335">
        <property type="protein sequence ID" value="ADW70335"/>
        <property type="gene ID" value="AciX9_3326"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3326"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688434_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="400" mass="43155" checksum="02A77661D66330AB" modified="2011-04-05" version="1">MALRGTLTHRKTRRLAQALGIDPPCALGVMEALWHVTGEQCPDGAVGVMSNDDLAMEMFSSVEPDKLVDALILAGLLDRDGTHRLVVHDWHEHSDDTTDLRLGRATRRYATGALPRLTKLSHVERERIWAKYEGTKAEISPQKASSSVYVPQKATESHGVALPVPVPEPVPEPVPGEKLLPLGAQPPPGKLVASANAKRPPSGPQAVLPMIPESANPGRCAEIMLERLAVAAPEKTRRLAADAIRLHAAKLGVSPQKATLLIEGLAVKSQARGEPVNAFWFEDSKWKGAAVANPAAIGMHRPDAVVEPQPEPAAAPEGADTETGRRVWEGMAKAIKAAIGPKSFETWVSPFRQLGILDGVIYLEMPSDNFEHVPDRYELANYLPPTVGEIRFVMGKGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q8</accession>
    <name>E8X2Q8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">AciX9_3347</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3347"/>
    <dbReference type="EnsemblBacteria" id="ADW70355">
        <property type="protein sequence ID" value="ADW70355"/>
        <property type="gene ID" value="AciX9_3347"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3347"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_2_0"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="21646" checksum="EFB4EF62366DF0C6" modified="2011-04-05" version="1">MPDFMPNYMELPVGPKSPEVINVVIEIPQEGVNKYEYDKDLHVFRLDRNLYSPVHYPGDYGFIPSTLGDDGDPLDVLVLVDSPSFSGCVMEVRPIGLLEMMDQGLGDEKVLCVGMGNPRYKDVWNYSEIYPHMLKEITHFFAIYKDLEGKRVEVKGWRDAAFARNKVTEAQARWIEHQKNPEAKPVPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z4</accession>
    <name>E8X2Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1065</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579451.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1065"/>
    <dbReference type="EnsemblBacteria" id="ADW68128">
        <property type="protein sequence ID" value="ADW68128"/>
        <property type="gene ID" value="AciX9_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1065"/>
    <dbReference type="eggNOG" id="COG3967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_0"/>
    <dbReference type="OMA" id="WSMNLRT"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="27096" checksum="2987804BABA71961" modified="2011-04-05" version="1">MKLTGNTIFITGGGSGIGRGLAEALHGLGNEVIISGRRKGHLDEVTKANPGMKSVELDIASPESIKSVAAKLIAEYPKLNVVINNAGIFSVDTAEGVLDDEVLVSTVTTNVFGPLRMTSALIEHLKGQDAAAVIYVTSGLAFTPLAMAAVYNSTKAAIHSYALSQRYKLKGTSVKVLEIAPPYVQTELGGDQQLNDPRAMPLKEFIDETIKVLGTDADEVLTERVKPLRNNVGPNEYEFVVKMNDMMTAAGHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X355</accession>
    <name>E8X355_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2238</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69279">
        <property type="protein sequence ID" value="ADW69279"/>
        <property type="gene ID" value="AciX9_2238"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2238"/>
    <dbReference type="HOGENOM" id="CLU_1710696_0_0_0"/>
    <dbReference type="OrthoDB" id="2007599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="153" mass="17341" checksum="ACFACB72D3614420" modified="2011-04-05" version="1">MKRRYSAEVTYATSVSDLVQRFPKYQEEIRGYMDDDEPLPFIALGCVIIPHLEEALREADLKVILSFCAYFEDIAVSSASDSDLENLLGIEVGEWLGFMENEDRLSPWLGPETKRLCRYVPGLATQRREHKANAAASSFLRRIGVRLGLVQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X398</accession>
    <name>E8X398_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581711.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3393"/>
    <dbReference type="EnsemblBacteria" id="ADW70399">
        <property type="protein sequence ID" value="ADW70399"/>
        <property type="gene ID" value="AciX9_3393"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3393"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_1_0"/>
    <dbReference type="OMA" id="ETLRWWD"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230195" evidence="1">
        <location>
            <begin position="18"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="388"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="658" mass="73211" checksum="29B921ABE387284C" modified="2011-04-05" version="1">MRLPLTALLLLTPIAFAQGRRAPMSPEETQALIAKRQSIEKQLEDIAVIDRKVMVPMRDGIHVATDIYRPKDTTKTYPIIFSRTPYNFNFWDVRLGTYRDMSQELDAVKRGYVLIEMNERGHFFSEGNYDILGAPLTDADDQFNWMGTQPWSNGKVGLIGCSSTAEWQMAAASLGNKHLTTIIPQSFGAGVGKVGPYNEQGNWYRGGAVQMLFIDWLAGEQNQIRPNFPPGTSQADLIQGSKLFDLSISPPPVDWAKAFEHLPEKDIISAAGGPKGIFSDKMPNTTGGAMIERTPNDPAWRKGGLWQSDTMPINVPGFWFMTWYDVSIGPNLAAYNFVRSTAKGEAANQQYAVIAPTLHCGYTRATEHTVVGERDMGDARLDWGAMTYAWFDHFLKGEDNKFLEKTPKVQYYTMGLNKWQHSETWPPEGAKPVTLTLASAGHANTLHGDGKLIFPISVPVRRSVPTPDVPDHFTYDPMHPTPSYGGNVCCAANTIPGMGGALDQRKMEERDDILVYTSDPLTEPMELSGPITATLYVSSDVKDTDVTVKLIDVDAEGKAYNLDETIQRLRYREGDDKMVWMEKDKVYKVTLTPMNTSNLFPAGHRIRLEVAGSNFPRFDRNLNTGGNNYDETTAVTAHTAIHHSTQYPSTITVTVAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C9</accession>
    <name>E8X3C9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3424</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581742.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3424"/>
    <dbReference type="EnsemblBacteria" id="ADW70430">
        <property type="protein sequence ID" value="ADW70430"/>
        <property type="gene ID" value="AciX9_3424"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3424"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138490_0_0_0"/>
    <dbReference type="OMA" id="MSNLMGA"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="14981" checksum="11EC59A41B35B245" modified="2011-04-05" version="1">MEHIPILRMGDLLLITIQVDMHDRLAITLQDDLTEQVVRYASRGVLIDISALEVVDSFIGRMLGNIAAMSRVLDAQTVVVGMQPAVAITLVELGLSLPGIRTALNVERGMQILRAESALSQPAPELEEVLDDDGQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F1</accession>
    <name>E8X3F1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferrochelatase</fullName>
            <ecNumber evidence="6">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemH</name>
        <name evidence="8" type="ordered locus">AciX9_3447</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581763.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3447"/>
    <dbReference type="EnsemblBacteria" id="ADW70452">
        <property type="protein sequence ID" value="ADW70452"/>
        <property type="gene ID" value="AciX9_3447"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3447"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_2_1_0"/>
    <dbReference type="OMA" id="LGDPYHC"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="37983" checksum="92133E0C927A0A37" modified="2011-04-05" version="1">MSQPDAILLLAHGTPDVLSEMAEYLSKVTNGRPLPAAVVEELQHRYAEIGLQETPLPDGPPLTRLTLQQSRMLADELEIPVYVGMRNWHPYIADVVTQMRADGVRHFKAICLAPQNSRTSVGLYRSVTAKAAAEEPAMQMDFVAGWAEHPLLAAAFAERLWPAWAEACATTGRRVPVLFTAHSVPCRTIMMGTVQSATSPSAEPGRPVPAEGIQNYGARTEPDPYPVEAKRTAALVAQALAPVGMTDRDWYFAFQSQGVAGGPWIGPTVEDTFKALVAEGHTAVVMQPIGFLCDHVEILYDIDIAFAETGRELGLKVSRAESLNASEPLIRALKTIAEGTYKADVEELAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H4</accession>
    <name>E8X3H4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1102</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1102"/>
    <dbReference type="EnsemblBacteria" id="ADW68165">
        <property type="protein sequence ID" value="ADW68165"/>
        <property type="gene ID" value="AciX9_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1102"/>
    <dbReference type="eggNOG" id="COG2316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090635_1_1_0"/>
    <dbReference type="OMA" id="EMLGWEL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="22237" checksum="FF57C62AC2EEA6B2" modified="2011-04-05" version="1">MEGFSVRREEALELMEQWTQGESLRKHGLSVSFCCEAYGRLEASRLGLSREAAEELVDSYACAGLLHDFDYERHPTPEEHPFVGVAYLRAAGWPAEILHAILAHADYSGVRPESYLDKVLFACDELAGFLTACSLVKPTKSIHDVEVKGVVKKMKDKGFARAVKREDMTQGAELLGVSLEEHVGVCLGAMQGKAGELGLGGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R4</accession>
    <name>E8X3R4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2305</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69342">
        <property type="protein sequence ID" value="ADW69342"/>
        <property type="gene ID" value="AciX9_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2305"/>
    <dbReference type="HOGENOM" id="CLU_3290361_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="40" mass="4416" checksum="BF8C1DA87145DAF1" modified="2011-04-05" version="1">MESELESHVRPAALAASIGWHSLGTILDNKNGMTPRSDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W1</accession>
    <name>E8X3W1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3464</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581780.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3464"/>
    <dbReference type="EnsemblBacteria" id="ADW70469">
        <property type="protein sequence ID" value="ADW70469"/>
        <property type="gene ID" value="AciX9_3464"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3464"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_0_0"/>
    <dbReference type="OMA" id="WSIRDDW"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233635" evidence="1">
        <location>
            <begin position="26"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="368"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="647" mass="72139" checksum="575AE69D85F9277B" modified="2011-04-05" version="1">MRPQRVLLPLALACTSALVPFAAPAQAPSQAPPAQPAAPYDVKANYTKTEYHVKMRDGVTLFTSVYAPKDTSKTYPFLVSRTCYSVAPYGPDKYRPSLGPSRAFAESGYIFVYQDVRGRYGSEGEWLEMTPHIDHPTGTQHDESTDMYDTVEWLLKTIPHNNGKVGIYGISYPGFYTSASIIDGHPAIKAASPQAPVTDLHDNDDAYHNGAFMLEANDFYRSFRPQKNPIPEPPRPDNTPFDYADAYTAYLKQWEPLSKARAFVANPYFDDQSNHPNYDSYWDVRDISRHLHNIHAAVLTVGGWFDAEDLSGPHKTFQSIAKQSPDASNKLVIGPWVHGGWSVLDGERIGDVHFGSKTGDYFRDKLQFPFFEHYLKDAPDPNLAVATVFETGSNTWKTYTAWPPAGSKPRMMYFGPHGTLSLTPSPAASGSGAYDEYVSDPTHPVPELSYTAEPGPSRDYMVADQRFAATRPDVLVYQTEPLTEDITFAGPLRARLHVSTSGTDSDFVVKLIDVYPQQEPTPPQRRGRGGERPVDVLLPPVLTPGYEQLVRGEPMRGKFRKSLAKPEPFTPNKPESVDFSLVQVNHTFLKGHRIMVQVQSSWFPLVDLNPQTFVDISNAKPEDFKPATERVFHSADLPSGIEFQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X461</accession>
    <name>E8X461_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0030"/>
    <dbReference type="EnsemblBacteria" id="ADW67121">
        <property type="protein sequence ID" value="ADW67121"/>
        <property type="gene ID" value="AciX9_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0030"/>
    <dbReference type="eggNOG" id="ENOG502ZHYH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2154807_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="12206" checksum="53B9588E10B74827" modified="2011-04-05" version="1">MAGRFVKGTTDEPEESTSLGRKGVRNPRFFKTFARKQFAEALPVIVSVLLDKAKSGSVSHLKLLVELSGLEKDPDPKKMKPRGKSLEAILTEQWAKDKAEAALKPATGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K4</accession>
    <name>E8X4K4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2377</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580730.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2377"/>
    <dbReference type="EnsemblBacteria" id="ADW69414">
        <property type="protein sequence ID" value="ADW69414"/>
        <property type="gene ID" value="AciX9_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2377"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107587_2_0_0"/>
    <dbReference type="OMA" id="ADHNAYH"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="18522" checksum="61D73E06D8BBBB89" modified="2011-04-05" version="1">MPAKHEDPLIAQLIALLDGGQAHADFDTATKDFPVDARGKVPENLPYSAWQILEHLRITQRDILNFTAPPTGGYHGMEWPKDYWPESAEPPTVHAWDQTIAAIREDRTKFDALLTKPNADLYRPFTWGNGQNLLREALLIADHNAYHLGELVVIRRLLGVWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T9</accession>
    <name>E8X4T9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ordered locus">AciX9_3574</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581889.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3574"/>
    <dbReference type="EnsemblBacteria" id="ADW70578">
        <property type="protein sequence ID" value="ADW70578"/>
        <property type="gene ID" value="AciX9_3574"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3574"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_0"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="189"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="360" mass="38735" checksum="09BF45EC42B1826D" modified="2011-04-05" version="1">MPDDNAQATPAEPKKAKSISYADAGVDITSGDRAKQRIKMLARKTFNKQVLSEIGGFGGLFALDLAKYPEPVLVSSADGVGTKLKVAFELGIHHTVGADLVNHCVNDIAVQGATPLFFLDYLATGRLENDVVETVVRGISEACRANGCALIGGETAQMPGFYADGEYDLAGTIIGAVNRPNIITGEGIEAGDVLLGLPSNGLHTNGYSLARKLLFEVAKYGPEHYVNELKDKAGAALMRTHRSYLSVIKKLTAQPEMVRGMAHITGGGITENLPRILPKGLDAVIDLSAWTPPPLFEHLQHLGNVDRDEMFRTFNMGIGLIAVIPAEQVKKAKAILNRANERHCIIGRIVTRGTRKVVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y6</accession>
    <name>E8X4Y6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0088</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578507.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0088"/>
    <dbReference type="EnsemblBacteria" id="ADW67178">
        <property type="protein sequence ID" value="ADW67178"/>
        <property type="gene ID" value="AciX9_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0088"/>
    <dbReference type="eggNOG" id="ENOG502ZWFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1658390_0_0_0"/>
    <dbReference type="OMA" id="RETTRCK"/>
    <dbReference type="OrthoDB" id="2084117at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="17592" checksum="E6E3808DA3C83A1B" modified="2011-04-05" version="1">MVLEVRGIEQSTQKFIQLWGKHVSGFNPQKQCIHCLKGRNEPQINRGMTSGDYEILTGAPYFYLFAMGRAPRSDSNVHLAVQPYPGAAASIVSLYGVTFTIRDARALRIDRIPGGWLGMDDLFTTFRSFQFGVQMFGYHLPENTPKTGDYSLLPEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X555</accession>
    <name>E8X555_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579642.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1257"/>
    <dbReference type="EnsemblBacteria" id="ADW68319">
        <property type="protein sequence ID" value="ADW68319"/>
        <property type="gene ID" value="AciX9_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1257"/>
    <dbReference type="eggNOG" id="ENOG50336Z6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181618_0_0_0"/>
    <dbReference type="OMA" id="IYMDLMA"/>
    <dbReference type="OrthoDB" id="2044262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="11893" checksum="957C7C02A01A720E" modified="2011-04-05" version="1">MASALPVIFNPRRKSLIRANALVLISFLIAVRLSRFPENHATLWLVLPVLIACVGTADTIRNMQPRWSFYHGGVVLCIYMDLMALAMMLFFLFYPYALWLSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C6</accession>
    <name>E8X5C6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">AciX9_2438</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580789.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2438"/>
    <dbReference type="EnsemblBacteria" id="ADW69473">
        <property type="protein sequence ID" value="ADW69473"/>
        <property type="gene ID" value="AciX9_2438"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2438"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_0"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="679" mass="71892" checksum="8D305F895BFBD0B2" modified="2011-04-05" version="1">MANTSKRSLWDSKIISRALGDAFVKLDPRMMMKNPVMFVVEVGSVITSIYVVRNLMGGHHSLRFDLQISLWLWFTVLFANFAEAMAEGRGKAQADALRKAKSETTAVRFKLDGTTENVASSDLRSGDVCLIIAGSMIPGDGEVIEGVASVDESAITGESAPVIREAGGDRSAVTGGTRVLSDQIKVRITSNPGETFLDRMIALVEGAERQKTPNEIALNILLAGLTIIFLLAVVTLQPIAIYSNAPQSVFVLISLLVCLIPTTIGGLLSAIGIAGMDRLVQYNVLAMSGRAVEAAGDVSTLLLDKTGTITLGNRQASEFLPAPGVSKDQLADAAQISSLPDETPEGRSIVVLAKEKYGLRGRELADLKAEFVPFSALTRMSGVDMEGRSIRKGATDSIAAFIKGYGGTMPDEVRSAVETVARAGGTPLVVAENGRALGVIHLKDIVKGGMKERFAQLRAMGIKTIMITGDNPLTAAAIAREAGVDDFLAEAKPKDKMDLIRREQADGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAGNMVDLDSNPTKLIEIVEIGKQLLMTRGALTTFSIANDVAKYFAILPAMFAATFPVLNALNIMHLKTPQSAILSAVIFNALIIVGLIPLALRGVGYKPMSAEALLRRNLLIYGVGGLIAPFLGIKLIDLLITAIHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C9</accession>
    <name>E8X5C9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2441</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580792.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2441"/>
    <dbReference type="EnsemblBacteria" id="ADW69476">
        <property type="protein sequence ID" value="ADW69476"/>
        <property type="gene ID" value="AciX9_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2441"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="DNVWGYQ"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="238" mass="26830" checksum="3B12FCD06CEA941B" modified="2011-04-05" version="1">MDKQDKHEGAVLLVEDDRSIRRGLFATLSAMGFALGEAESGEEALLKLHVLPYDAVLMDLNMPGMGGIEACRRVRKEYPHISILVVTVRDREEDKIEALDAGADDFVTKPFKMGELAARIRSAVRRQRTPVAIEKVINVGVFSLIPDRRLLKKSGEEIKLTPTEFDLLSYLMAHAGHPIMHSKLLSTVWGPAYGDEREYLRTFILQLRRKIEDDPSNPVYLKTVNYLGYLFSDPDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H8</accession>
    <name>E8X5H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580841.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2493"/>
    <dbReference type="EnsemblBacteria" id="ADW69525">
        <property type="protein sequence ID" value="ADW69525"/>
        <property type="gene ID" value="AciX9_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2493"/>
    <dbReference type="HOGENOM" id="CLU_1150586_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234192" evidence="1">
        <location>
            <begin position="23"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="241" mass="25581" checksum="64AC53855D0FAB9D" modified="2011-04-05" version="1">MNPIPRLILTLACAAVPLAAQTTTPDAPHPAHLRAVMRPPATTLPPRAALLSTAESAATRGIKPPLQTLPDFPVTDRDGHTTSAQTVGTHLIAARTPATPIAAQATTLALQPTAPAPPTHWLLLYRTQTCLPCDRLMNTLAASTSSDFQRGTPYIVLVATHTRTGLETVRAANPTFNSATWLADTTHQALTTLKPRGTPMLYAMDGNRIAFSIPGNLDNPTLVTTIADSWIKNTAKPLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J9</accession>
    <name>E8X5J9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ordered locus">AciX9_3623</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581937.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3623"/>
    <dbReference type="EnsemblBacteria" id="ADW70626">
        <property type="protein sequence ID" value="ADW70626"/>
        <property type="gene ID" value="AciX9_3623"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3623"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_0"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="34999" checksum="4E7171929E7E5673" modified="2011-04-05" version="1">MELFRQPNVDWLGKKWYFLAFSLVFSVAGVFSLLFWHHLPLGVDFKGGTQVVTRFDSTPNEDHVRAAMDKAGIHDARIQRISGAANEVSNQVVIALPESTATDSNHDQGRSAVENALKANYSDSGFQVLQVDIVGPTAGKQLQKQAVYATIYSLIGMLVYLWFRFELIYGVAAVVAVFHDTLITVGAFSLTNQEITLTVIAAILTLIGYSMNDTVVVFDRIRENLALSRREPLADVVNRSINQTLSRTVLSSGLTFLTVLSIYLFGGEVLHGFSFALVVGILIGTYSSIAVAAPMLVAWQDWRAKQGKASATLPAGRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q1</accession>
    <name>E8X5Q1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S protein assembly chaperone HscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3677</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581987.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3677"/>
    <dbReference type="EnsemblBacteria" id="ADW70678">
        <property type="protein sequence ID" value="ADW70678"/>
        <property type="gene ID" value="AciX9_3677"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3677"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_0"/>
    <dbReference type="OMA" id="PDPHQRR"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010236">
        <property type="entry name" value="ISC_FeS_clus_asmbl_HscA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01991">
        <property type="entry name" value="HscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="667" mass="70961" checksum="7524A1C2B773642C" modified="2011-04-05" version="1">MAEERVVGIDLGTTNSLVAFMQGDTPVVIPGEDGERLVPSVVAWTDNGVAVGNAARATLMQDSASAVYSAKRLMGRDITDIQDELKLFPFRLADDAKAGEVLRLNVGGLTLTPPEISAYVLQQLKRNAERFLGGAVTKAVITVPAYFNDAQRQATKDAGRIAGLDVLRLVNEPTAAALAYGLDKQKDGVIAVYDLGGGTFDISILKLHEGIFEVISTGGDTHLGGDDIDNLLIAIALDDISGDLGVDVGGNPEAIQAIRKAVIDAKIALSLNKSAHLNVTLPGQKHYRREITREQFDQLVAPVITRTAGPVRQALADAQLTPAQIDEVVMVGGSTRIPAVRTLVTQLFDLEARGKKLHTELNPDEVVALGAAVQARILAGGSAATEDLLLLDVTPLSLGIEALGGVVAKIIQRNSTIPASATEHFTTGVDGQTNVAIHVVQGERELAKDCRSLARFDLKGIPPMVAGLPRIEVKFLIDANGILHVSAREQRSRKEAEIEVKPTYGLTDEQVETMILDSFDNAEQDITERQVIEAKNEAETIMTAVEKGKSTPAWQQLSFDEIAKIEAATTELKASLKGGDHKIIRKAIEALDQATRRFAEIMMDSAVSGAMKGQTMAAAGESMGQNLGASPSAPHAFAPAEINPGKESDGLTQIELNPETPGESTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W7</accession>
    <name>E8X5W7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4062</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572763.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70851">
        <property type="protein sequence ID" value="ADW70851"/>
        <property type="gene ID" value="AciX9_4062"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4062"/>
    <dbReference type="HOGENOM" id="CLU_045947_0_0_0"/>
    <dbReference type="OMA" id="FDPNHEM"/>
    <dbReference type="OrthoDB" id="587274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230761" evidence="2">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="396" mass="42977" checksum="62E605686F86463F" modified="2011-04-05" version="1">MHSRIALAVLLVFPCAAGMLAQTSPTQDAAVHLNQIQVIGSHNSYNLGFAPSEEKFARMHNAKSYESLEYHHATLTTQLNGGVRQLEIDIVQDEQGGRFAHPRVVELTKEAGLPPDPDFDPNHEMEKPGFKVIHIADLNERSSCHLFTGCLQEIRTWSKEHPSHIPLFLLIETKHGNTPSIPNSVTAEAFTPATFDAVDRAIRSVFTDKEMVLPDQVRGSYSTMDAAVRAGHWPTLAASRGKVIFLLDQRNDGVAYTAGHPALEGRVLFTNAVPGRPDAAFTEENGGTPDEIDALVRQGYLIRARADEGTVAARTNDTTRRDELLHSGAQIISTDYPLSEPSSWAAYSVGFVNGLPARCNIINAPLACMDNLLEPGTRSGGTPSPQNDTAAQSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z5</accession>
    <name>E8X5Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572791.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70879">
        <property type="protein sequence ID" value="ADW70879"/>
        <property type="gene ID" value="AciX9_4099"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4099"/>
    <dbReference type="HOGENOM" id="CLU_052511_1_0_0"/>
    <dbReference type="OMA" id="ILMSCAD"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="214" mass="22204" checksum="5ABDBA387E66A102" modified="2011-04-05" version="1">MSDSPKKPDQDQEPGRVTRRSFLSHIGAAGVAATTAPLAAAAQSSAPSPARATDAAEPIEGAIPVALSINGKSYALNLDPRTTLLDALRETVSLTGTKKGCDHGQCGACTVHVDGRRINSCLTLAVMHDGQQITTIEGLGQPDALHAMQAAFVEHDGYQCGYCTSGQIMSAVALLKEPCGPADADVKEAMAGNICRCGAYPNIVAAIQHVRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Z7</accession>
    <name>E8X5Z7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4101</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572793.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70881">
        <property type="protein sequence ID" value="ADW70881"/>
        <property type="gene ID" value="AciX9_4101"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4101"/>
    <dbReference type="HOGENOM" id="CLU_342222_0_0_0"/>
    <dbReference type="OMA" id="FTEIDTW"/>
    <dbReference type="OrthoDB" id="141905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230767" evidence="2">
        <location>
            <begin position="22"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="867" mass="91342" checksum="848FFF3CDB98577E" modified="2011-04-05" version="1">MRALNVAACLLATSFVTALHAEDAARFDLAGPKIKVRVTRGDTTLPIAQVPNLQPGDKLWIKADLPATQSNHLILIVAFLRGTTNEPPDNWFTEIDTWEKKTIEGTTVTVPAEAQQAVMFLAPETGGDFKTLRSAVKGKPGLFIRADADLNQASFEQQRIERYLAAMKTVSPTDSKAIQDHSTKLAATLALKPNADCFKQPVDQQVTCLTQSSAPVLLDDGHGQTVAEALSTGPSSDFINAASYTSAAGAGVYSAYVGAVVDLVHLVGTLRTAQYQYIPGLSFPDGESLSLRLNTPPSFHKPESVIVIGLPAIQKAALPPLRLHNADQVACLLQPKVALQLEGAPLVFSSSFAHDLVLHLNRTGDTTDLPLHPDAFEGGLIVSENDKRQPLKPASDKPKPEKTDAKPGSPTDLTITGKVSGYWGFDAFDGPTVTLQQVRGKDWKIVGNTQLLAGQDNHLTLKGDGDACVQHIALASEKAKDVDVTYKAADGKDAKDTLNLDVPLKTVQPGGYSLAILQYGDKDQDKVPLTAYNAGIKLENLKIHGGDNTAILTGEGLKDVVSVDVDKQTFTPTGDSNDDKTVHLQAKSGVSPDDGADATVKLKDGRTMPVNIAAEAARPGLNLLSFKATAAQKDDSMPVTLGAKDDIPLDGTLTFVVQTKDAMPRTQTIEVATLDGSVTTALSLAANNLVLQDDHTAVATLDPLKSFGQSAFGKLQMRPVASDGTPGAWTPLGTLVRSPSIKAIHCTTQDAPTCTLDGSNLFLVQSFGAGKDFAKPADVPTGYADSTYLVPTPSDGSTIYLKLRDDPNALASVTLPAAIPKPAPAAPTAQNVPAAQTTPSQSITVAPASPAAKPTVADPTQTPADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X618</accession>
    <name>E8X618_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4122</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572814.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70902">
        <property type="protein sequence ID" value="ADW70902"/>
        <property type="gene ID" value="AciX9_4122"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4122"/>
    <dbReference type="HOGENOM" id="CLU_1842292_0_0_0"/>
    <dbReference type="OrthoDB" id="2192420at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="14289" checksum="E33B24EB8159F7F2" modified="2011-04-05" version="1">MTFDVQSSQFNDLATQSDRLLQRTQAAANASATPSLEDAKITKAGKDFESILLGSWLQQAENSFGSVPGGDEDDDAGSGKDQFQGIAMQAMAGSLTASGGIGIAKMITSHLHSAADSEKAGAHAKPGANSTTISGRKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X641</accession>
    <name>E8X641_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar assembly protein FliH/Type III secretion system HrpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70925">
        <property type="protein sequence ID" value="ADW70925"/>
        <property type="gene ID" value="AciX9_4145"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4145"/>
    <dbReference type="HOGENOM" id="CLU_1259955_0_0_0"/>
    <dbReference type="OMA" id="HREVEMD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="24349" checksum="5B2E177EC0F81D3A" modified="2011-04-05" version="1">MSSSKSPSKNLFQFPVAEFKYRQMQPQIVTAPAMAAHAALAIAEDHSEEDLTRRLAAEHARGAAETESCLRGEYEGRSQHETARISKTIAEFEKTRKDYFAKVESEVVHLALAIAAKILHRESQVDPMLVAALVQIALGQLKEGSAATIRVRPDNAQRWHQHFASLSMKLSIEIVEDTELQPGDCILETELGSVNFSLDVQLKEVQQGFFDVLSHKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X648</accession>
    <name>E8X648_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4152</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572844.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70932">
        <property type="protein sequence ID" value="ADW70932"/>
        <property type="gene ID" value="AciX9_4152"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4152"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="IWLCASG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="211"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="45265" checksum="83521EC4736134B6" modified="2011-04-05" version="1">MEYLSHHEPINVPGLIAPPDVFVLADAFSEFISASSRLEASYGKLQLEVTHLSHELADRNFALKASLAENERVHRALQQIVDSMPCGVLVVDGDGDISMINPECRRLLDLDEAPAQCLETISAQTGIDLAGFLHRHTSSEEEQEFCRNSTSGKRWLSVHDRCLFRGDETDPYGRGVRQTILILRDVTVHKQAEQERERARKATALSEVATTLAHEIRNPLTSLELFAGLIAAGGEGTDEWISHLRAGIRSLAGTVNNVLSFHGVGFPSLTAIDLVTSIRSSVEFVRPIADEAGVSLLFASAGSKLMVRGNSSALQQVVLNIICNAIRHTEKGGTIQVSVLVAERQDSTFAVIEFADTGSGITQEHLEEIFRPGFSGSGNSSGLGLAVCSQIVKQHEGNIRVTSTVGTGTTFFVEIPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X660</accession>
    <name>E8X660_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4164</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572856.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70944">
        <property type="protein sequence ID" value="ADW70944"/>
        <property type="gene ID" value="AciX9_4164"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4164"/>
    <dbReference type="HOGENOM" id="CLU_637376_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="430" mass="47335" checksum="7308F70859D579BF" modified="2011-04-05" version="1">MLYEPFPGGAAVVLTQLGLLEEGQAEGLGVRTFDAESGRLSLAMDDGRVIELVRATHARIENRYAVLVRAGGLAEDRGFIQIDRNFGVTDLLKHQVVYPETAHDEPVSHVSEDEMVDAPSDEVVDDETTRIHEVKRPVETQVTASDEIEASGDDKADAIVAEAAEAEVEPLAEVEEARIEDWDWAEPVRPFEPVDEAKAVWIEPVFEVVPDVEAGRVSQVEAEVESVPVVVTEAEDLPNVETEALAVAEAELEDESVAAAPEVHAEDEADAARMRYYRPLVEAFEPDVVVMFGWIAETGTIQTYEHRATGRYMHIDGASGLFYDQTRTPISQAAALRHAMPTDSVRERAKAAFFEEPPIEETPEAPAMLATRQSVRVSDEAPHGDELGLDTFVRKDANGGEPNERESWRKRIAGLGRTFRLGKNMGRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N2</accession>
    <name>E8X6N2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3906</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71182">
        <property type="protein sequence ID" value="ADW71182"/>
        <property type="gene ID" value="AciX9_3906"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3906"/>
    <dbReference type="HOGENOM" id="CLU_012817_10_6_0"/>
    <dbReference type="OMA" id="EAQHWPT"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="48629" checksum="0B85D6A637A2862D" modified="2011-04-05" version="1">MFGTRARTLVIQVSLMFFNVFLLWGQAPVRLQASPLAQATLTPSDVVLTLAQVEDQAIKNQPRIQAAQLRAKAYQERIRESRAGLLPVLAFNATGVLVADTGTSTAAGNITTSAISNRFAYGGNLTQLVTDFGRTSALVSSAKRTAEAQGEFATLTRAQIRLNVRDAYYQVLGAEAVLKAAHEAQGNRALISRQVGALAQSQLRSTLDVNFAGVLESEAELAVVQAESIVHQRRDQLTTAMGDQHSVIAALAEEPLPAALPPDPEGLLGQAQQDRADLNTLRLEQKAADQFAKAERKLSYPSLNVLGSAGELPFHDHTLHDSYAAAGFNLNIPILNGGLFSARRSEAQLEASARSRDVEETKLEVTQQVRDAWYQANESFRSLAVTSRLVSQSREALHLAQARYDSGLGSIVELNEAQLNEFSAEISAAGAKYTYLSRRATLDFATGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N3</accession>
    <name>E8X6N3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3907</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582201.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71183">
        <property type="protein sequence ID" value="ADW71183"/>
        <property type="gene ID" value="AciX9_3907"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3907"/>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_0"/>
    <dbReference type="OMA" id="TTGERWQ"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234253" evidence="2">
        <location>
            <begin position="26"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="63"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="43168" checksum="5DDB85C870F60AA3" modified="2011-04-05" version="1">MRLSSYMLAACSLVGSGLLCSCHSAPPPPTATDNPVVPVAAVKTENLSNEMVLTAEFIPYQDVDVMAKVSGYVRSIRVDIGDHVKQGDLLATLEVPELQDEQGKAAAGVSAAQANILTAQAAERRAKAQADIAHLSYQRILDVSKKEVGLVPRQEIDVAQSRDLEAAAQLASAQSAIQAAQENQTVATSERSRAGAMLQYATIRAPFSGVITKRYANTGSMIQAGISSQTQAMPVVRLAQNSVLRLMLPVPVSAVSLIHNGQAVDVNVTTLGRKFPGTVTRYADSLQTSTRTMETEVDVKNTDNTLVPGMYAEVHLHLADRPNALSVPLDAVDGLGTGAQQVWIVRDGQLHQVKVTTGIQTATRVEIVSGLQLGQQVVVGRHSGLTEGEKVEPHVAAYDQESISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q5</accession>
    <name>E8X6Q5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ordered locus">AciX9_3929</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582223.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71205">
        <property type="protein sequence ID" value="ADW71205"/>
        <property type="gene ID" value="AciX9_3929"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3929"/>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="258"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="53075" checksum="5318862F0DE69D51" modified="2011-04-05" version="1">MYLGIDCGTQGTKALLVDENGSPLGRGYAKHLLIEGESGAREQEPKWWVEALKSSVRIALGQAGSAEVSALGVSGQQHGLVVLDEAYEVIRPAKLWNDTQTAGQNAELIELLGGRDECLRRFGILPLTGYTASKLLWMKQVEPANFKRIRHILLPHEYLNFWLTGEMKAEYGDASGTAFFDVRTRMWAREVLDAIDGRTGQLFRALPPLMGSEETVGVVLEEVARELGIPPGCIVSSGGGDNMMGAIGTGNVREGVVTMSLGTSSTVYSYQDHPSDDRTGEVAPFCSSSGGWLPLVCTMNATNVVMGTLNLLGKTVEEIELALAEIKPGADGLTFLPFLNGERTPDLPLARGSLVGISAMNYTASHLVRAAVEGVSFGILSGLNLILKGRRPEVILVIGGGARSEGWRQLLADATGASVRVPAEEESGCLGAAMQAMVAYSRAYGGAITLVEVADRCAKISADATLTPRPELREAYDRARQLYTERLHSAYPHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U2</accession>
    <name>E8X6U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3966</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582260.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71242">
        <property type="protein sequence ID" value="ADW71242"/>
        <property type="gene ID" value="AciX9_3966"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3966"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="EAQVMAM"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="250" mass="25623" checksum="C4031E26DCAC1323" modified="2011-04-05" version="1">MANLTNKVAVVTGASKGIGASIAKHLAAAGASVVVNYASSKEGADNVVAEIVKAGGKAVAVGGSVAKEDEVINLFAKAKEAYGKLDILINNAGVFAFSPIDQFSADDYRRQYDTNVLGVFLATKHAIPLFPETGGSIVNISSVVSTLAPPFGSVYSSTKGALDTITKSLAKELGPRKIRVNAINPGMVETEGAIGLGIIGSDMEKQTIATTPLGRTGQPEDIALPTVFLASDDARWITGETIFVSGGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V2</accession>
    <name>E8X6V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582270.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71252">
        <property type="protein sequence ID" value="ADW71252"/>
        <property type="gene ID" value="AciX9_3978"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3978"/>
    <dbReference type="HOGENOM" id="CLU_2665961_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8425" checksum="29C059CC06DC83C7" modified="2011-04-05" version="1">MLTSSSLLTAVFALPPLPAMLLRHLGNTTWQQFLILVGGATLAFSLLLYLCTLPSTLRKIRRRKLLKKQGFQDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z5</accession>
    <name>E8X6Z5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3818</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582126.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71104">
        <property type="protein sequence ID" value="ADW71104"/>
        <property type="gene ID" value="AciX9_3818"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3818"/>
    <dbReference type="HOGENOM" id="CLU_1212656_0_0_0"/>
    <dbReference type="OMA" id="FSRLHHQ"/>
    <dbReference type="OrthoDB" id="1313493at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="29491" checksum="C5E796B46F074120" modified="2011-04-05" version="1">MPAEIILQQSPEVAALIERRERLAAVRTALAERESGLAQTRARLKSFEGRYLRQVGILYAELDELEARIAEREVDLYDSEAARRRAVEARQRAQETHDAAFSDAHEAEEFDPPPNLKALFREVAKRIHPDFARDDAEQEHFTLLMMRANQAYSRGDTEALQRLLDDYREVNTSTAEEGAAAELLRIVRQIQHAERDLAKLDAEEQELLASELGQLHLDAEAAAGEHRDLLAELASSLREQVAEAQHRFELIDRQIGAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X745</accession>
    <name>E8X745_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572998.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71279">
        <property type="protein sequence ID" value="ADW71279"/>
        <property type="gene ID" value="AciX9_4325"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4325"/>
    <dbReference type="HOGENOM" id="CLU_020336_16_2_0"/>
    <dbReference type="OMA" id="YLEWNPQ"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="34082" checksum="298DD8F916296974" modified="2011-04-05" version="1">MSVSKIKTKVLRQAYEQTGPTKGEPLILVHGWPDSPRTWDKVLPLLHQAGYQTIVPYLRGYGPCSFRDPLLGRKPRRTGQPVAFAQDIIHLADHLDIKRFHFIGHDWGARTGYALAALFSKRLRSLTAVSVPFEPGKASPPKFPQAEAFWYQWLLCTNPGEKKFREDPTAFGQAQWDAWSPAGWYKHSDLAAAAKSWEGKDFEDVVLHGYRSRWGHAEQDPQYADLQSRFDSTKTLNTPTLLLHGREDHCELVDTTDGAERYFTSPYHRVLLDGVGHFPQRESPELSAAIILKHIRQNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X779</accession>
    <name>E8X779_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71313">
        <property type="protein sequence ID" value="ADW71313"/>
        <property type="gene ID" value="AciX9_4361"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4361"/>
    <dbReference type="HOGENOM" id="CLU_3136215_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="5634" checksum="98596BA5FCC6DD00" modified="2011-04-05" version="1">MMCVQNESPDVSSHPSNELNRSLPLFERKRVTKNDQGKILPSDQFLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B7</accession>
    <name>E8X7B7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4400</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71351">
        <property type="protein sequence ID" value="ADW71351"/>
        <property type="gene ID" value="AciX9_4400"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4400"/>
    <dbReference type="HOGENOM" id="CLU_035990_6_4_0"/>
    <dbReference type="OMA" id="WQLTATI"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="25103" checksum="6566588C0A5CC2D6" modified="2011-04-05" version="1">MCGRYRRKSDKQQIAEAFHVSGPGIDSLMLAPDDDIRPTTFQPIIRADEDGSPMMELARWGFVPFFHKAEKFPPTTFNARAEGIEKAPMWRHSLEAKRCLIPADSFFEWKHIAKKGNPKYEFLVGGGVPFAFAGLWSGWTNPVDKTELHSFTIITTDPNSLLEKYHNRMPVILKPSEYTRWLTGDRVPLELLRPFNAEAMTATCVDPGTAVTAREATLFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z8</accession>
    <name>E8X7Z8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4652</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71582">
        <property type="protein sequence ID" value="ADW71582"/>
        <property type="gene ID" value="AciX9_4652"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4652"/>
    <dbReference type="HOGENOM" id="CLU_021240_1_0_0"/>
    <dbReference type="OMA" id="WTLEYDL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01026">
        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="172"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="617" mass="67651" checksum="3E54A58422AB2809" modified="2011-04-05" version="1">MEVFLGDVVYLSQLTIRNFRKLERVDVSFQSGLNILVGPNNVGKTAVIDALRALLGGHDEPLPRLSSDDLFRSKTGEVATAIEFGYVFSGLDLDDEADFLPSLIATGPGKSLEAHFHIRYSDPEKSSGRLRVKRWSGALEENSLNSEMTENLRGVYLPPLRDVALGLRPSRSSQLARLIHILADEAGQSGIEKALEKLDTDLKSHPPIIDIQLAITGHHEKMLGAQLAQVLEVGLSASDFQRFSSRLSLMVDSFDVEQNGLGFNNLIFMTVVLSELARNPEITYRGLIVEEPEAHLHPHLQSILLQYLEKVKSLKKSQKSATENLGEKEPPAESVAEEEVGDEIEGAVQVFVTSHSPHFASIAKLSSLVCLVEGDTGTKSFLPRSVVFDKGKREKLERYLDVTRAELFFAKRIIFVEGAAELMLVSVMAQKCGYNLRDYAVSLISVEGLNFDCFLPLFGEDSIRVPVAVITDADPFTMVGEESVPVYPGANDAIEISANAKVLLQSTDQFIGVFHGQKTLEYDLALFESNRTLMLKALKVLHPGIGATLDKEVAAAKGDAAKAKVLFSGMFERSSNNVQKGRFGQVLAQELLDAKNDCAVPPYIKKAIEHVCCGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X823</accession>
    <name>E8X823_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein UCP028570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4678</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71607">
        <property type="protein sequence ID" value="ADW71607"/>
        <property type="gene ID" value="AciX9_4678"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4678"/>
    <dbReference type="HOGENOM" id="CLU_137813_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016891">
        <property type="entry name" value="DUF2321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10083">
        <property type="entry name" value="DUF2321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="16891" checksum="0DC376C7753CBCF2" modified="2011-04-05" version="1">MGFAAYCKNGHLVGIVQSPRTGSDLRRLAERHATGIPFFSPFCKECGEATVSQCPHCEARIELNAKYCGSCGKVLPWTENALAAARAYTDDLDEFTSDEKEKLNENFKVLTKDSPSVPLAVRLLQKAVAKAGPVVGSAILEIAKTLATAEAKKHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV99</accession>
    <name>E8WV99_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0200"/>
    <dbReference type="EnsemblBacteria" id="ADW67274">
        <property type="protein sequence ID" value="ADW67274"/>
        <property type="gene ID" value="AciX9_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0200"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526543_0_0_0"/>
    <dbReference type="OMA" id="MIWIGRG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017802">
        <property type="entry name" value="VWFA-rel_acidobac-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03436">
        <property type="entry name" value="acidobact_VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230340" evidence="2">
        <location>
            <begin position="30"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="575" mass="62520" checksum="3253AC121CC3EC09" modified="2011-04-05" version="1">MSKSSLSLYALALGLASLSSSFASLQAQAAPQTPPPAAAPSQQIQAPVATPAPAAAPGQVGAPGNQPVKNPDGTYTIRNNARLVVLDMVVTDPKGKVVTDLKKEDFHVTEAGDPENILNFEVAGSRTPDPSITINSTADLDRLAPRAPVNIILLDEFNTRFEDEAFARYSLKKFLEKQPDKLDTPTMLIAVDLQHFTVLHDYTQNKQEVIAALDHHFVAYPWQVHQGAWLGERYGTAFMTLRRVAEAVIGHPGHKNMIWIGRGFPALNFANQPIDTENRVNNAVQECVNVLRDARVTLYTIDPAGLQVNPGVYGNAAAFNDPFGGEYQFNKLAKATGGRTLYGRNDVDAEIGSAIQDGSNFYTLTYRPAGNSLDPQKFRKIKVTVDRPNVTVYTREGYYLQRGPGRVNPLNPSRRLMADLASADSSTMVYDGVPLTMWNLPNDPDTYRIRIDARGLAWTYATDTEPRHTEVILAVTTFDKKGKQLSVVAKNVIAKAPSDVPPTGRLERPLIIAYKVDHDAKAVRARFVVRVTASGRIGTADATLGQPIPEQTPIASIPTPAPPTPPVTPAPTPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF0</accession>
    <name>E8WVF0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1338</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579721.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1338"/>
    <dbReference type="EnsemblBacteria" id="ADW68398">
        <property type="protein sequence ID" value="ADW68398"/>
        <property type="gene ID" value="AciX9_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1338"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027829_2_3_0"/>
    <dbReference type="OMA" id="INWGRYG"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="50060" checksum="F73E84A1DA337A1B" modified="2011-04-05" version="1">MPEVLIRAERVEKYYAQPSENRIQVIAPTDLSIVKGEIVALLGPSGSGKSTLMRMLTGLSAPSAGQVFWHEKPIASTDVNVSIVFQSFALFPWLTVQENVEAVLKARGMNADERRKRSLKMLDTVGLDGFQAAYPKELSGGMRQRVGFARALVVEPEVLFMDEPFSALDVLTAENLRSELLELWQNKTLPTQAIFIVTHNIEEAVLLADRIIVLGRNPGRVRTDFKVTLTHPRNRKAVAFTQLVDYIYKVLTQPDAPTPQLPNAAGDRDARRTYQMLPHARPGGIAGLLEILIDHEGKDDIYKLADDLAFEIDDLLPIVDAAQLLGFLTVNEGDAAITPTGTEFANSEILRQKELFRTAAVDNVLLLRQIVRALETKSDGEVAEEFFHDVLDEQFSEEETLRQLETAISWGRYAELFDFDAARHRFMQPERLHPAPEELATVDTESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG0</accession>
    <name>E8WVG0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1348</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1348"/>
    <dbReference type="EnsemblBacteria" id="ADW68408">
        <property type="protein sequence ID" value="ADW68408"/>
        <property type="gene ID" value="AciX9_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1348"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118928_0_0_0"/>
    <dbReference type="OMA" id="NAIARME"/>
    <dbReference type="OrthoDB" id="1598573at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="25867" checksum="4260F83941A5CF63" modified="2011-04-05" version="1">MCAKSFENPLTPHKRLREIYAAMVETRVLGKRLRKGFAQGTEACWVGTAIGLIDAEGDVVSAGKTGALVDYVVGAKLKAVLKDQTSEAKTPAERLYFALGAASRMAAEGKVLLAFVLAGDLPAVEWKRIFSEALRLELPIVFVVVPEKRSEPGLADVALKLGLPGIPVDASDAVAMYRVAQESIGRARAGGGPALIEGVVFPATGDPIALLGRQLIAKGAATQAWIDKVEPRFRTKLPKETVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ8</accession>
    <name>E8WVJ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1387</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1387"/>
    <dbReference type="EnsemblBacteria" id="ADW68446">
        <property type="protein sequence ID" value="ADW68446"/>
        <property type="gene ID" value="AciX9_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1387"/>
    <dbReference type="HOGENOM" id="CLU_3270751_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="41" mass="4987" checksum="021BDA511891BF1C" modified="2011-04-05" version="1">MYVLPIVALSWVFGRYVIPWLFYLAVIYGSDRDMFSTHRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC8</accession>
    <name>E8WWC8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1458</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579831.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1458"/>
    <dbReference type="EnsemblBacteria" id="ADW68511">
        <property type="protein sequence ID" value="ADW68511"/>
        <property type="gene ID" value="AciX9_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1458"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155142_0_0_0"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="240" mass="26927" checksum="2E8916D9FB36766B" modified="2011-04-05" version="1">MQTATQTDELIVWTKPQALEEAKSVFASYGPKFRTAGNEKGPVFSKGQVGVVYLSHSEEDSAIETTLAALRNAKVSSIVFYVPHQSADFAFKVGTMMGRRKGISAEWAFNFPHLRQLLKARNIRAHVRHQENHASSFDLLEARRRLGLSQTQLASALNVTVRTLQNWEVGKGTSLLAKKTGDLRDLLSRMDDYVVAPKETEWLSSPLEAFGSRTPQQLIVEGRMRDIVIEFDRLREGQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWG8</accession>
    <name>E8WWG8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zeta_toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2607</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580947.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2607"/>
    <dbReference type="EnsemblBacteria" id="ADW69632">
        <property type="protein sequence ID" value="ADW69632"/>
        <property type="gene ID" value="AciX9_2607"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2607"/>
    <dbReference type="eggNOG" id="COG4185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094497_2_0_0"/>
    <dbReference type="OMA" id="YIIAGCN"/>
    <dbReference type="OrthoDB" id="1933465at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21083" checksum="8EF868EFD2411CC9" modified="2011-04-05" version="1">MSQPVLTIIAGSNGCGKSTLTSTARDKFQQTPILDPDAIAKSLQAVQDSPSSNIEAGKRVLKLAEELIEKKQTFTVETTLSGGTYLKMAARAKQAGFTLMVVFIGTASVDINLKRVKARVAKGGHDVPEEDQRRRYPRTLANMKRLLPQADLAVVLDNSTEKGHTLVAFGHAGYMHWIEPVPSWAAHLCAELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ0</accession>
    <name>E8WWJ0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2629</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580969.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2629"/>
    <dbReference type="EnsemblBacteria" id="ADW69654">
        <property type="protein sequence ID" value="ADW69654"/>
        <property type="gene ID" value="AciX9_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2629"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_2_0"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="291" mass="32214" checksum="823BEC52B9F43467" modified="2011-04-05" version="1">MSEFLLAGVAEGIAREAGALLREFYAKGVAMEYKGDVDLVTEADRASEALIKARLSEAFPEHGIYGEEGTREGLEREFRWYVDPLDGTTNFAHGFPVFCVVLGCERRAAGLSADEDGEMVAGVIYDPLRDEAFVAERGKGAWLNGKRIHVSKAKTLQESLTGTGFPSSKRHENPNVHFYQEMTLRSHGVRRAGSAALDLAYVACGRLDGYWEFKLNPWDTSAGYLLVEEAGGTVTHFDGGKFTLDSREVFATNGLIKDEMQHIFTEMFAGRGMERIPTPAEFRARRETSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ2</accession>
    <name>E8WWJ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid stable inheritance protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2631</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2631"/>
    <dbReference type="EnsemblBacteria" id="ADW69656">
        <property type="protein sequence ID" value="ADW69656"/>
        <property type="gene ID" value="AciX9_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2631"/>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150554_2_0_0"/>
    <dbReference type="OMA" id="CDPHAEI"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="84" mass="9311" checksum="39E763DABDDCC55D" modified="2011-04-05" version="1">MHVTSLQRVDGVLMMEVPEALERELHLHDGSTVEVGVESGRVVLSGSKAPKYTMQELLDQCDGEMVRSEEDEAWLNVASVGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM8</accession>
    <name>E8WWM8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3773</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582081.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3773"/>
    <dbReference type="EnsemblBacteria" id="ADW70773">
        <property type="protein sequence ID" value="ADW70773"/>
        <property type="gene ID" value="AciX9_3773"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3773"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_0"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="277" mass="30104" checksum="B1B5F749EACFDE98" modified="2011-04-05" version="1">MKADKSAPPETPAHKTKVIAVVNQKGGVGKTTTAVNLAAGLAVAGHATLLIDCDPQANTTGGLGFRRQKDAEEQRLSIYDILLGPTTLMEAIQPTPIDNLKLIPGSKNLIGANIELVEAERREYRLRDAIALLNNDFRFIVLDCPPALDLLTLNALVAAEGLLVPLQAEYYALEGVSELISTLDKVAQAFNPELALEGVLLTMYDDRTNLSQQVAANLKEFFGDKLLKTTIPRNVRLAEAPSHGLPVELYDPRSRGAEAYRDLTKEILERNNIALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP1</accession>
    <name>E8WWP1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yidC</name>
        <name evidence="16" type="ordered locus">AciX9_3786</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582094.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3786"/>
    <dbReference type="EnsemblBacteria" id="ADW70786">
        <property type="protein sequence ID" value="ADW70786"/>
        <property type="gene ID" value="AciX9_3786"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3786"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_3_0_0"/>
    <dbReference type="OMA" id="WGIFGWI"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="89"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="607" mass="66548" checksum="C333002A65F764B8" modified="2011-04-05" version="1">MAEFRNPNQPGASQDNRSLFTIMAIMILVFAGLQFWRAKHNPQTASPNGQTQQQQANQPTPTVAASVAGQTIQVPAVQPVVAAAESTTVVENELYKITFSNKGAQATSWILKKYKDSYGQPLDLVHTLAAQTVGYPLSLYTYDPSLTASLNNALYLPSATGNITAPQTLTFKYVSGEYQVTKTFSFDDTYILHADTQVLRNGSPIRALVAWPGGFGDQEDAKSYGGSQVDYSQEQKEKHLAVGKVTGGNTLNGSFDWAGASDLYFAAIFLPDAPDSATVATLDSSIIVPKANRHNGLGHGVPVAPKGEPGKDEIKVPIIGAAVGDLSGHTQTRLFAGPKAVAVLRNVHSAGNKTSLEPLLDFGFFGIIGKYLFLALFAIHQYVTPNWGWCIVILTVLINLLILPLRIKTMQSGLKMQRIQPQMDAVKARYKNLKVTDPKRNEMNAEIMQLQKDNGVNMFGGCVPTLIQMPLLFAFFGMLPKVVELRQAHWFWLPDLSSADPYHILPILMVISQFLVQFYTPSPGVDPQQQKMMAFMMPVFSGYMTWNYSSGLALYWSVGNLISIATQFIMNKTSIGQEMREIAAKRARRKAGEGVNSKTIQGKTVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWR8</accession>
    <name>E8WWR8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ordered locus">AciX9_0324</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578724.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0324"/>
    <dbReference type="EnsemblBacteria" id="ADW67396">
        <property type="protein sequence ID" value="ADW67396"/>
        <property type="gene ID" value="AciX9_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0324"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_0"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17010" checksum="804FAFB4BB13C7EA" modified="2011-04-05" version="1">MEVILKEDVVKLGHRGDVVKVADGYGRNYLLPGKLAIEATAANKAVIDQMKASAVRKSVKEKGAAEDLAKQISAVELTFERKVGENEQLFGSVTSGDIAQGLEAQGFTVDRRKISLEEPLRSLGEFHVPVKLYREVTAHVKVTIKSDAPDEVAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS7</accession>
    <name>E8WWS7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578733.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0333"/>
    <dbReference type="EnsemblBacteria" id="ADW67405">
        <property type="protein sequence ID" value="ADW67405"/>
        <property type="gene ID" value="AciX9_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0333"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084253_4_1_0"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="19371" checksum="E1C9637F0E448C21" modified="2011-04-05" version="1">MSNLDSMLERNKAFAAQQSAAGTLMPSLADAAHHAKAIIIGCADMRVDPADILGLHPGEALVIRNIGGRITPVLIEELGLLGRIGKVTQQPAGGGGEFHLIVFQHTDCGITRLAGDPAMLAHYFHIPEADVPGKSVTDPHAAVIGDVELLRSIPALPASWLLSGLVYDVATGLVETVVPAAPLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX40</accession>
    <name>E8WX40_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580997.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2657"/>
    <dbReference type="EnsemblBacteria" id="ADW69682">
        <property type="protein sequence ID" value="ADW69682"/>
        <property type="gene ID" value="AciX9_2657"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2657"/>
    <dbReference type="eggNOG" id="ENOG5033JPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2682635_0_0_0"/>
    <dbReference type="OMA" id="MGCLPTG"/>
    <dbReference type="OrthoDB" id="1997643at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="74" mass="7721" checksum="F411AFD690DDE090" modified="2011-04-05" version="1">MQQDTRKLLTTGIAIFGTGAVCAALALFVFGGIGHQGPHTNAGWLCLMIAMGCLPTGVLTLFLGIAKLAGDYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA8</accession>
    <name>E8WXA8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0369</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578769.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0369"/>
    <dbReference type="EnsemblBacteria" id="ADW67441">
        <property type="protein sequence ID" value="ADW67441"/>
        <property type="gene ID" value="AciX9_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0369"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061503_0_0_0"/>
    <dbReference type="OMA" id="FHVNINS"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="40"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="39276" checksum="E7EAFEFA2DF2DB2C" modified="2011-04-05" version="1">MAETIAKAPDSRKWTARRRLIAATRKMRELGSIGSALLDTGHPYMAHIVPMRRCNLACTYCNEFDQTSDPVEIVEMERRIDELGRLGTAVITISGGEPLLHPELDRIIARIRKTGAIAGMITNGYLLMPDRIERLNKAGLDHMQISIDNVMPDEVSKKSLKVLDAKLKMLAQHADFHVNINSVVGGGIANPTDALTVSERALALGFSSTIGIIHDGSGQLKPLGDEERTVWDRVRKLTRRSYSRFNHFQEAIANGKPNDWRCRAGARYLYICEFGLVHYCSQQRGYPGVPLADYKRADVKREFLTEKGCAPNCTISCVHQVSYIDHWRAPQVFSNHPPGAKHGAPPELVQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD8</accession>
    <name>E8WXD8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_0399</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0399"/>
    <dbReference type="EnsemblBacteria" id="ADW67471">
        <property type="protein sequence ID" value="ADW67471"/>
        <property type="gene ID" value="AciX9_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0399"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_2_0"/>
    <dbReference type="OMA" id="CRTRGEH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="49"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW67471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="41670" checksum="ED84E94CBA65CD08" modified="2011-04-05" version="1">MDVVGKDGLDSTHVLAFRRKLTHWYREHARELPWRGVHDPYKTWVSEVMLQQTRVAAVLEHYDRFLKLFPTIIALALAPEDEVLAAWSGLGYYRRARMLHKAAQFVVKELAGKIPGQSDELRKLPGVGEYTCAAIASIAFGESIAVVDGNVERVLLRVTGRAEEATAAGKAFIRVQAGLLVPHKRVAHHSNAAGDHNQGMMELGATVCLPRGPLCLGCPVYDLCATKGEHVTAPKGKQRSQTVAYLLETRKDGARTEVLLERRGDESSLMPGMLELPMLPLDAVEEREPILRVRHSITNTNYYVEIYTAPGMGDKKLRAAIPAARETLSWAGVGRLKELPLTGLARKVLMRMDLMGVAGPESPEMMRDEVRKALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE3</accession>
    <name>E8WXE3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578804.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0404"/>
    <dbReference type="EnsemblBacteria" id="ADW67476">
        <property type="protein sequence ID" value="ADW67476"/>
        <property type="gene ID" value="AciX9_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0404"/>
    <dbReference type="eggNOG" id="ENOG5033FNU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137316_0_0_0"/>
    <dbReference type="OMA" id="CAWIMAT"/>
    <dbReference type="OrthoDB" id="1900774at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="16062" checksum="6874B5DAEAB3375B" modified="2011-04-05" version="1">MHPLSIVVRHPRQTAAAATGAAAVIALAAYAIFRKRPTAEEIEALRRDRLAAAGRISDGSLLDAFPSLDEPHVLVYTYRIAGVTYECSQDVSLFADRIHGPRAESALLDLPIQVRYDRANPADSIVIADTWNGLWSVETDLTSHPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN8</accession>
    <name>E8WXN8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1601</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579973.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1601"/>
    <dbReference type="EnsemblBacteria" id="ADW68654">
        <property type="protein sequence ID" value="ADW68654"/>
        <property type="gene ID" value="AciX9_1601"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1601"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972422_0_0_0"/>
    <dbReference type="OrthoDB" id="731668at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233470" description="DUF4097 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="123"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="342" mass="35051" checksum="8B79025031FAA94F" modified="2011-04-05" version="1">MNKFSALLLATPLLLSGYAAASEPGSFNKTLTVSGPVKLDVKSGPGGIKISVGSSDTVVVHAVIRSVLGRFDPGLADANIRALEQNPPIEQHGNDIRIGYVADQAILKGVTVTYDIETPRQTQVNASADAGGIRIDGVQGPVETTNDAGHTEVSGIQAALKMTARAGGLVVQDAGNDVSITNQSGGILMHGVHGSVTAETTNGRIEISDVTGDVHSATRSASIRLDGIKGGVNARNLSGSIESFQSGSSVNAETSSGSIRISQSQPAPIRALSSSGAIHVELASGGGYDLDAQSIKGKISGKATEAFAKTKDQKDQRSFKGRIGSGGPLVDLDTKSSKIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ8</accession>
    <name>E8WXQ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2729</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581068.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2729"/>
    <dbReference type="EnsemblBacteria" id="ADW69753">
        <property type="protein sequence ID" value="ADW69753"/>
        <property type="gene ID" value="AciX9_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2729"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_1_1_0"/>
    <dbReference type="OMA" id="FAFFANP"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="21610" checksum="0D626863995F521E" modified="2011-04-05" version="1">MRHHFQAEQWLPYPIEHVFAFFSNPENLPRLMPAWQKARIEEAAFAPPPPRPAGLPIFPGIVAGAGTRMTISFRPIPFSPIRVPWDAEITEFTWNEHFCDVQHRGPFKFWRHCHRLTPEPRANTGREVQGTLIRDEVEYELPLGPLGELAAKLFAPAQFKSIFDFRHKRTAELMPLLRVRETPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXZ8</accession>
    <name>E8WXZ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0465</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578865.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0465"/>
    <dbReference type="EnsemblBacteria" id="ADW67537">
        <property type="protein sequence ID" value="ADW67537"/>
        <property type="gene ID" value="AciX9_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0465"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033160_2_1_0"/>
    <dbReference type="OMA" id="WDRLQIR"/>
    <dbReference type="OrthoDB" id="1513532at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="151"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="417" mass="45899" checksum="D96A5F962AA28CE7" modified="2011-04-05" version="1">MADNSQFDHAVQAVFSVCASPDVASAAMAACPEVQGSVFAGEFNDYFSGERRPQISQTLKAATGCVALVDCDRDPEQALQTMERLRALMLRNLSVVAYATKVDATYLLQAMRVGCNEFLTKPASTDALEEALNRFRAAHISEAGGQPNSGRVISFFGAKGGAGTTTLAVHLANNLVRRHRKRTLLIDHHHELGHISLYLGLKGGQYHFDELIRNSDRLDGNLLNGFVTRHTGGLEVLASPDVVAADYKSSPEEINSVFAFLRTQYDFIVVDSSMDYKDIVPTMQQSSDEVYLVSTPDVASLRDLARRVEHLRLTDPASEKLRIIINRSTSDDAVTAEQIEAAVRFPVWMAIPNNYADLVRAINAGEPIPPQHRSAFAQQINKWADKILSVMAAPLDQPTTHKKGFTLFRSKRDKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY00</accession>
    <name>E8WY00_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0467</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578867.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0467"/>
    <dbReference type="EnsemblBacteria" id="ADW67539">
        <property type="protein sequence ID" value="ADW67539"/>
        <property type="gene ID" value="AciX9_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0467"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064305_0_1_0"/>
    <dbReference type="OMA" id="ETRMSAW"/>
    <dbReference type="OrthoDB" id="1002350at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="153"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="34909" checksum="7AE1C6DFADBDF88D" modified="2011-04-05" version="1">MLVTIFIGALILSFGLVLFLLRPDDAEKALERKLRVISSDARKEQAETEGYALTVKKAEGILFEIGEMVERYHFSQDLQQLILHSGTETTVGSVIGISAVLAVAAALLAHIFLGIYIVDAVAFVVGGSARWMQLKWKKSSRLGKFEEALPDAIDLMARALRAGHAMSSAIEVVAEESAEPLAGEFAIVFQQQKFGLQFRDALLQLGDRVPSKDLSFLITAILVQKETGGDLTDVLDRTTRVIRERIRIQGEIRTYTAQGRLTGWILSALPVVMLCLINVATPGYSHILFHDPTGQLLLGAGGVLILIGGFIISRVVDIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY08</accession>
    <name>E8WY08_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0475</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578875.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0475"/>
    <dbReference type="EnsemblBacteria" id="ADW67547">
        <property type="protein sequence ID" value="ADW67547"/>
        <property type="gene ID" value="AciX9_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0475"/>
    <dbReference type="eggNOG" id="ENOG5033B3J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650148_0_0_0"/>
    <dbReference type="OMA" id="WYARYAW"/>
    <dbReference type="OrthoDB" id="2149134at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45601" checksum="675C1EA7277FE092" modified="2011-04-05" version="1">MDVHGSPTVGPRHKAGLPPAFRLIVALLLFCQICACVAGAGPSLGGKVDFRPFYASGTLIRTGHAAQLYDYNVQQQVQNAVVSQRDAALPFLYPPFAALLFVPLSLLSYRNAFFLLLVLNLGCLYLAAQLLRPWLPSFRDQGRLTLPTVYGCLFAVSVALMQGQISFLLLLIFSGAWIMLQRQKPFVAGLLLSLALMKFQLALPVFLLFLVWRNWAVVSGFIAGGCGLSAISFATVGWGGLLSYKNSLTGIAAQTATNAVLAKQRFGMFPVDMPNLHGLSYGLSRGAHWGNILDAVLSVLILIFAARQRPSLLVALPAAMLVSYHMQPHDLVLLLLPLSFLADDLVQRRALMRQGQIALPARRPIDKTLLAASLLLILPLAAVFMAKGLNYLIAFTVAVVMVAAARRVAPAESGDVDLPVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY47</accession>
    <name>E8WY47_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1621</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579993.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1621"/>
    <dbReference type="EnsemblBacteria" id="ADW68674">
        <property type="protein sequence ID" value="ADW68674"/>
        <property type="gene ID" value="AciX9_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1621"/>
    <dbReference type="eggNOG" id="ENOG5032YT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177114_0_1_0"/>
    <dbReference type="OMA" id="HTMWVEL"/>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8070" checksum="21D6FB2F2CB2CC6B" modified="2011-04-05" version="1">MLVRFDADSMWIELSDGRTLGVPLAWFPRLLQATPEQREGVAISSRGLHWEGLDEDISIAGLLAGYRDQTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY55</accession>
    <name>E8WY55_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580001.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1630"/>
    <dbReference type="EnsemblBacteria" id="ADW68682">
        <property type="protein sequence ID" value="ADW68682"/>
        <property type="gene ID" value="AciX9_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1630"/>
    <dbReference type="eggNOG" id="COG4655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528697_0_0_0"/>
    <dbReference type="OrthoDB" id="2223251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018705">
        <property type="entry name" value="DUF2134_membrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09977">
        <property type="entry name" value="Tad_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="3">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Tad_C" evidence="2">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="515" mass="53807" checksum="300AF2402B6D43AF" modified="2011-04-05" version="1">MNRLNKLFCLFLRDQRGQVLPIAGLMMFVITAMIGLVVDVGHIYLCQRELQASSDAAALAGAEIIPTATTAAAVYAKATAYSSTTGAANVYKNMTNITMVSGYPILKCLSTMQTQGISCVGPLSYNSIQVMQQAVVPLYFARIIGRSSMTISATSTAAKGGASSRPYNVALVLDTTYSEISYDSDCGNSQMLCTLQGVQILLNQLDPCGTSVTTCSVTSGQATNSVVRVGIFTFPQMVTSTVSSDYDCSSNTPANTVYTFPIPGAGTYAPSSSTYRVLDFQSDYRVGDTSTSLNQASNLTKAVGGFSGCTGIYPATSASQSNFQATSGQYGTYYPSTIYAAQSSLIHEQTLFPDSQNVMIIIGDGNATAPQTNNGYPVMSTTASVSATPGASTLAGTSSGLYPSWNGECGQAITAANFATSQGTRVYTVAYGSPSAGCASDQSGQGKIPGLYPNVLPCNEMAQMASASYYFFSDFKQSGSGSVCTAAQVMVELSDIFLQIAGDLTVARLIPNSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY69</accession>
    <name>E8WY69_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1644</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580015.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1644"/>
    <dbReference type="EnsemblBacteria" id="ADW68696">
        <property type="protein sequence ID" value="ADW68696"/>
        <property type="gene ID" value="AciX9_1644"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1644"/>
    <dbReference type="eggNOG" id="COG4102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032896_1_0_0"/>
    <dbReference type="OMA" id="VEMGVEN"/>
    <dbReference type="OrthoDB" id="663130at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="447" mass="46460" checksum="73BCB0140E4E2D56" modified="2011-04-05" version="1">MATNRRSFIKYASLAAAGNAAGLRPFGMLNSLAQSATDYKALVCVFLYGGNDANNLLIPNDTKGYANYATVRGPLALAQSGLLPLGSNGLYALNPNLPDIQTLFNSNNAALVTNVGTLIQPTTRAEYLAAGATVPTNLFSHTDQQLEWQNAAQSGATPSGWAGRIADTISTQYNPNGKIPMITSVAGDTLFCNGANSTPVSVSPGNLGGASCSEGTTECAAQQMTAQQLVSFSSGLSLVQADNSITSNAYTYAKTLSDAVQSVNALKTVFPANNGLAAQLKQIAQIIQVQASLGVSRQIFFAGVGNFDTHSDQITLQGNLLAQISPALAAFYAATQELNVANNVTTFTMSDFSRTFQPNSNTGSDHAWGAHHMVLGGAVKGGKMYGTFPTLALAGPDDSGSNGRWVPTTASVQYAATLASWFGVSNAQMSSIFPNIGSFSTANLGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYL2</accession>
    <name>E8WYL2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0538</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578938.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0538"/>
    <dbReference type="EnsemblBacteria" id="ADW67610">
        <property type="protein sequence ID" value="ADW67610"/>
        <property type="gene ID" value="AciX9_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0538"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552937_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="265"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="493" mass="53801" checksum="8D67954B1398EC8F" modified="2011-04-05" version="1">MMVAAWLGLSVGGFQAVDHWACLLAMAGLAGMGWQMRRRATHQRIERMRERRLREELEGYARLDVRTGAGDPVAQARALAKRVCRTIADLSAFPKVAMLLRDAEGRMYCASSAGVDDLTVRALLAWGESAVEEERGARLRTKTGMKGGAKKHPKSFSIQLGEWTKFDPEVAAWALSGKKERRRWRRGMVAPIRMHDGHLLGAMVVCSDGSRADRNDGGYAQRLEVAIGPIELLAGRLAMSMESRLMSERLLRAEKLAGLGQLAGGVAHALNNPLTAVLGFAELIAESSHEESVRKDADTIRTEALRMRDTVQRLTEFWRPPVVVNEAVEMVTILDELGAACRATLEQRGVELVITSDEGMPAVRGSGERLKQVMEHLLNNAAQAIEDAGEREDGHAIRITLSHDETSVNVIVSDTGTGFQEPGRVFDPFYTTREPGDGDGMGLSMCYGIVREHGGEISAFNLHPHGAAVVVELPVSTVVSGESLPEMEHARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM3</accession>
    <name>E8WYM3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0549</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0549"/>
    <dbReference type="EnsemblBacteria" id="ADW67621">
        <property type="protein sequence ID" value="ADW67621"/>
        <property type="gene ID" value="AciX9_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0549"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_0"/>
    <dbReference type="OMA" id="QMAVWET"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="278"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="491" mass="53851" checksum="FF102057C41B7C5B" modified="2011-04-05" version="1">MSTSFSGLQDVTESRLRMIVDTIPAYIAYLDHEMRYVMVNRTYEEWFGRPAAEIVGRTVDEVLGDSAGNVKGHLLAALDGVSQQFEAPMRTALGDRYLRVQHVPDRDEEGRVRGVIVHGFDITERRNAEEALRESEERQRLALAAAGAIGTWDWDVQRNLVRADANFAAFYGVDAEAAAQGIAIEAFTKGVHPEDFVRVGEAIAHALVTGEEYTCEYRLVSEDGSVRWLSAYGRCSLAANGTPIRFPGVTVDITDRKMSEDALLRTEKLAAVGRLASSIAHEINNPLESVVNLLYLIEESVDGDADELRNYARVAQHELGRVSQIATQTLRFFKQTTASTEVNLGETVESVLALYKGRLLNSGVMVELGVRGGATLVSYEGELRQVLNNLVGNAIDAMRGGGRLVVRARPAMDGVSGRCGVRITVADTGMGMDAETARRIFEPFYTTKGILGTGLGLWVSTEIVQKHRGRLRVRSRRGFGTVFALFLPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW5</accession>
    <name>E8WYW5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580120.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1753"/>
    <dbReference type="EnsemblBacteria" id="ADW68801">
        <property type="protein sequence ID" value="ADW68801"/>
        <property type="gene ID" value="AciX9_1753"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1753"/>
    <dbReference type="eggNOG" id="ENOG502ZP7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2843696_0_0_0"/>
    <dbReference type="OMA" id="QSTHDRV"/>
    <dbReference type="OrthoDB" id="2101915at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7166" checksum="29FD994B8BDC94C9" modified="2011-04-05" version="1">MPQSTHDRVAELHNLAAHAHTAAATAHGKGDHLTAHELSQQATEHSREAHEASAKLHHGKAAALEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYY9</accession>
    <name>E8WYY9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malto-oligosyltrehalose synthase</fullName>
            <ecNumber evidence="2">5.4.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2881</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.15" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581219.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2881"/>
    <dbReference type="EnsemblBacteria" id="ADW69904">
        <property type="protein sequence ID" value="ADW69904"/>
        <property type="gene ID" value="AciX9_2881"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2881"/>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005045_1_0_0"/>
    <dbReference type="OMA" id="WTVVEKI"/>
    <dbReference type="OrthoDB" id="217555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047470">
        <property type="term" value="F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="5"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="893" mass="100619" checksum="3E953540ADAC16BB" modified="2011-04-05" version="1">MTKVPASTYRLQLHKGFKFDDAAAIAQYLYDLGVTHVYSSPYLQAAPDSMHGYDVVDHQRVNEELGGAEAHKRFSKTLGENGLGQVLDIVPNHMAIGRENRFWWDVLENGASSRYASFFDIDWQPQEERLRDKVLVPILADQYGRVLEAGDIKVIRNGPLFLVEAAGQTFPVAPTSLPAILARAADYSNSDTLRFIAASFGRLPQPSFEDRRTVLARHRDKAVLNTLLERLCAEDHPACTAIDRAIDDLNARHDALDDFLNQQNYRLAYWKTADQQLGYRRFFDVNSLIGLRMERAHVFEETHALILEWLRQGVLDGVRVDHPDGLRDPLEYFQRLRAAAPDAWIIGEKILEPGEFLRENWPIEGTSGYDFLNVALGVLVSPDGLEKLTQVYADFTAQPVDFHVIAHDKKIAVSQEALGSDVNRITSLLIEICENNRNYRDTTRAEARRALRELAGCFAIYRTYVVPSRNEINDEDRSYIHRAIECAKSNRADLPPTLFDFLEDILTLKVTGRLETEFTLRFQQFTSPVMAKGVEDTAFYCFNRLTGMCEVGGDPGRNGLTIDQFHEYQSKMQQTHPSTMTTLSTHDTKRADDVRARLSVLSELPEEFASAIQSWTAANEQFKANTFPDPNTEYFLYQTLIGAWPIDAERTKTYMLKAMREAKQQTSWVANNKPFEDALFAFIDAILTHAPFVDSLSEFVAKLLVPGRVNSLTQSLLKYTAPGVPDLYQGGELWDHSLVDPDNRRPVDYDLRRKLLAQIAVLPIDKISASINDPEDKGVAKLFLVHRALQLRRQQPTWFGPEAAYTPVKLTGPAASHALAYLRGDHVLTIVPLHTAALTDGWDDTAVQLPEGRWSNQLAEEPHRSGKVLLADLFTSFAVALLTRDDNDAPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ71</accession>
    <name>E8WZ71_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase with GAF(S) sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579001.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0602"/>
    <dbReference type="EnsemblBacteria" id="ADW67673">
        <property type="protein sequence ID" value="ADW67673"/>
        <property type="gene ID" value="AciX9_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0602"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_6_0"/>
    <dbReference type="OMA" id="HAGESCE"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="540" mass="57698" checksum="1637EE134F724E15" modified="2011-04-05" version="1">MPPTALLRYTDEAGEHTLPLDRDEITLGRADGQDIVVREQCVSRRHAAVVREGEAHFAVDHQSTLGTFVNGVRIERKRLRPGDVLQLGSPEATRIVFEPAPGAPASNPSSSVSSRGTVIFQALTSVKDFERLNWLLDAVRQLNMGGPIDEILAGFLQLTLQLTGLARGFVFLAEEGKQPMRLAAGRAATGEALAEDATLSQRAMQQAATTSKKFFVTDTLAEANVAGWQSVVINNIRSIYCLPLRRRNTQASPQPGHPDLLGVLYLDSHLGIDRMTNVDHELLDTIATEAAGLVENAVLAQAEEASREARRELTIAANIHSGLMANELPTVPYARIQAVSRPCLEIGGDFYDAIALPDCLCVTLADVSGKGVSAAIVAATLQGILYAQVTAGQPLAQIAAHLNRFLCARRIGKYATLVMLKIFPDGSMEYMNCGHIPPIVAGHGHARALDQGNLIVGLIPTATYESTRIQLAPGERVILVTDGVTEAENEAGDPFGDGHLTHAACGCTLHEILAEVSKFSAGAPASDDCTLLEISYTGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ77</accession>
    <name>E8WZ77_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0608</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579007.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0608"/>
    <dbReference type="EnsemblBacteria" id="ADW67679">
        <property type="protein sequence ID" value="ADW67679"/>
        <property type="gene ID" value="AciX9_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0608"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_0"/>
    <dbReference type="OMA" id="WIHLLFH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="42743" checksum="42597DD5B4BE9A2A" modified="2011-04-05" version="1">MAAYNVLIFGALLLGCGSGGLFVVRLTNPRLKGLAWLGAAFSVGGVGALLLVFEHVLPRLLGILGADLMILLAFVLLHVSFLELVEAESFVPKMGILLLVIQGAMSFLSINGTVTGRVRVMMVGLLVAVQVSETARLLIRHGKRDMRAPAWFNIVILAFFAVLNLARSIGMAVGTVTGTFAEQVATLAYGIYIAVALGLAFGFFWMTTATLSAALEHIASTDPLTRLYNRRAFRYWCDKEVKRSQSRGRLFSVLMIDLDHFKKINDRFGHLAGDGALCAAVEKMQDSIRGIDILGRWGGEEFILLLPGASPDSALVIADRLRLNVAKIMVGATGELHRLEEILGDPNDMMRVTVSLGVTTYRGKGDTVESMLKRADEGLYEAKATGRNRIVAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ87</accession>
    <name>E8WZ87_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhaT l-rhamnose-proton symport 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0618</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579017.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0618"/>
    <dbReference type="EnsemblBacteria" id="ADW67689">
        <property type="protein sequence ID" value="ADW67689"/>
        <property type="gene ID" value="AciX9_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0618"/>
    <dbReference type="eggNOG" id="ENOG502Z7ID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066437_0_0_0"/>
    <dbReference type="OMA" id="QFFFYGM"/>
    <dbReference type="OrthoDB" id="2047485at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015153">
        <property type="term" value="F:rhamnose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004673">
        <property type="entry name" value="L-rhamnose-proton_sym_RhaT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06379">
        <property type="entry name" value="RhaT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0769">Symport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="42912" checksum="4083135FEFE60DD7" modified="2011-04-05" version="1">MGSNPFIGVIYHWIGGFASATNFIPFRGIKRWSWEIYWLIQGVAAWIIAPLVLGCYFVPNLFRILRESYAAHPRNVIYALLFGILWGVGGLTFGLAIRYLGIALGYAIALGLCAAFGTVVPPIIHGQFGEILHQSSGQVILLGVAVCVIGVAVNGAAGISKDKEFTPEEKEEAGETDFNFGKGLAIAVLAGLMSSFFAFGLDAGKPIGDLTKERLLAGGRLDLWQNLPILVVVLWGGFITNFVWSSILILKNRSIGQFTGTPGLNPMRAAKTTGDTLADFDPEDPQYSERLSGATLLFNYLFAGLAGVIWYFQFFFYSMGQTKMGKYDFSSWTLHMASIIIFATLWGIFLKEWKGTSMRTKMLVACGLALLIGSTVIVGYGNYMKAAETLGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA4</accession>
    <name>E8WZA4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0635"/>
    <dbReference type="EnsemblBacteria" id="ADW67706">
        <property type="protein sequence ID" value="ADW67706"/>
        <property type="gene ID" value="AciX9_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0635"/>
    <dbReference type="eggNOG" id="COG2219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336976_0_0_0"/>
    <dbReference type="OMA" id="YEHIEHY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="24002" checksum="5529E4F75F29D634" modified="2011-04-05" version="1">MSEREVVLDQPQVTDEQSEALRNATERAEKAEAELAKLKTAKAPARTSEETKQPPSPSTEINTADVEDEESPDVETSGSADTGGVEELRKDSMMAHLLDSLAAGKDIGHHGRLVFAMVARHFLPHDEVLRYLTHDKDFSNEQALLMLRQVEGRDYSPPKRERILEWQSQQDFPILPDPEDPDCGNLYRNLKFPTEIYDHIGHYQEEKLHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA8</accession>
    <name>E8WZA8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0639</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579038.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0639"/>
    <dbReference type="EnsemblBacteria" id="ADW67710">
        <property type="protein sequence ID" value="ADW67710"/>
        <property type="gene ID" value="AciX9_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0639"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="28996" checksum="5689E810D6CC6B97" modified="2011-04-05" version="1">MNAPLFEISGLTKQYGSKRVVDEVSFSIQRGETLGLVGESGSGKSTVARMLLRLVEPSAGQIGFDGIDLLAAKTKKMRHLRRRIQMVFQDPYAALNPRMNIRQIISEPFAIQGGFSRDAVRQRLDELMGDVGLSPDVLSRYPHEFSGGQRQRINIARALALKPEFLALDEPVSALDVSVGAQVINLLKDLQRTHGLTYLFISHSMPLVRYLADRVAVMQNGKLVEIGDVLQVCERPREAYTQRLIAATPRLPDEEWNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC9</accession>
    <name>E8WZC9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1769</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68817">
        <property type="protein sequence ID" value="ADW68817"/>
        <property type="gene ID" value="AciX9_1769"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1769"/>
    <dbReference type="eggNOG" id="ENOG5033J04">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163278_0_0_0"/>
    <dbReference type="OMA" id="RDRWFDE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="10080" checksum="EB17028DD6B09F88" modified="2011-04-05" version="1">MNDHCCAMMSSNLAGGETAILYVPKFRDYGIPVLDGGGSFIAISHCPWCGQTLPHTLRDRWFTEIEARGFEIGDDNIPVEFATDAWWKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG9</accession>
    <name>E8WZG9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580176.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68857">
        <property type="protein sequence ID" value="ADW68857"/>
        <property type="gene ID" value="AciX9_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1809"/>
    <dbReference type="HOGENOM" id="CLU_1358840_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234006" evidence="1">
        <location>
            <begin position="26"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="201" mass="21232" checksum="7FF0B7F5074CD380" modified="2011-04-05" version="1">MHSIKLARVAASMAAVALFAAPALRAQARFAQTAPATWDIFGGYSALLPTGSNNNGINAKGFDVSISQRPYTSARWIGGTIEGSGSYLPSTVTTSGLNTIKTTASYYTLLGGPSVLLPARHIRPFARILFGTVIARSSTTVNGFTTSTRPATFAYSVGGGLDVPITHLFSLRAQADWLQFHNQDTSSTDKIRTSAGLAARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH1</accession>
    <name>E8WZH1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1811</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1811"/>
    <dbReference type="EnsemblBacteria" id="ADW68859">
        <property type="protein sequence ID" value="ADW68859"/>
        <property type="gene ID" value="AciX9_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1811"/>
    <dbReference type="HOGENOM" id="CLU_2569059_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="8805" checksum="6CF9E968B481FA3F" modified="2011-04-05" version="1">MASKTYAYEQILIAQTALKAAANPWTEEFPLPTIIGMLSDEIAALRQSGFSDESIAALIQKSSGIDLTAETLTSQYARPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK2</accession>
    <name>E8WZK2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="6" type="ordered locus">AciX9_2953</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581291.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2953"/>
    <dbReference type="EnsemblBacteria" id="ADW69976">
        <property type="protein sequence ID" value="ADW69976"/>
        <property type="gene ID" value="AciX9_2953"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2953"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_1_0"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="11177" checksum="DABA292326AD8C0C" modified="2011-04-05" version="1">MPTLYTVIRRPLITEKGMTVKETQNTLVFEVALKATKTEVKQAVESLFKVKVNGVRTATVEGKERRRGKFAGYRPDWKKAYVRLQEGEKMPEYLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL6</accession>
    <name>E8WZL6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2967</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2967"/>
    <dbReference type="EnsemblBacteria" id="ADW69990">
        <property type="protein sequence ID" value="ADW69990"/>
        <property type="gene ID" value="AciX9_2967"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2967"/>
    <dbReference type="eggNOG" id="ENOG50327Z4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1502771_0_0_0"/>
    <dbReference type="OMA" id="WPYGRVI"/>
    <dbReference type="OrthoDB" id="1722452at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="19458" checksum="9B1C338C7078A763" modified="2011-04-05" version="1">MRPTSFLLPLALLPLLTGCRSIPDASSAPNATAEQRAQFNDIRQQLDEIPPPSKTRYMAVKTLTSWENPYLTIQGQMVTLHVTIADANPSQFGNGGLLRPVGARRQDLNVRTSDLAAALNAVPTTAWPYGRVIAVEEAHDIPAAAKPEVRRNMEVAMKTINDLGIVLYEWQEGGASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ2</accession>
    <name>E8WZQ2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ordered locus">AciX9_3003</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell inner membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581340.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3003"/>
    <dbReference type="EnsemblBacteria" id="ADW70026">
        <property type="protein sequence ID" value="ADW70026"/>
        <property type="gene ID" value="AciX9_3003"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3003"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_2_0"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="14" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="295" mass="31609" checksum="2DF393CEE1ED5828" modified="2011-04-05" version="1">MPILQVIILAIVQGLAELLPVSSSAHVVVAEKLMGLDPTSPQMTLLLVMLHTGTMFAVIVYFWRRWVHTYFRSSAAFTSVVVRIAVATILTGVIGYPIQKVIEKVMFHGAPKAEIEQLFGRLDLIAIALFFVGLLILFAGLAERRSMTGRTTGASDEDMSLGQAGIIGATQGLSLPFRGFSRSGSTISAGMLAGVARESAETFSFALAVVLTPAVLAREGMRLVKFSHEAAAAGTPLDLHGAIGSSVLGMILAFVAGLAGLKWLSSWLEAGRWYLFGIYCLVMSAVVFFLHTRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X077</accession>
    <name>E8X077_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3038</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581372.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3038"/>
    <dbReference type="EnsemblBacteria" id="ADW70058">
        <property type="protein sequence ID" value="ADW70058"/>
        <property type="gene ID" value="AciX9_3038"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3038"/>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_2_0"/>
    <dbReference type="OMA" id="FRISHQL"/>
    <dbReference type="OrthoDB" id="1772839at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18459" checksum="91E052E485F296D3" modified="2011-04-05" version="1">MIVVADAGPLRYLIEIDLIAQIPAQYGELYVPGAVLNELSQPITPSSVKLWLAKPPFWFHIVDAADRTPKIPTLDLGESEALKLAIKLEADFLLIDDQAARKAAPKYINASVTGTLGVIYEVSRLSLRPAEEFRQNVGRLRLTTFYFSHQLNQVIDRLQAEMEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B2</accession>
    <name>E8X0B2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581407.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3073"/>
    <dbReference type="EnsemblBacteria" id="ADW70093">
        <property type="protein sequence ID" value="ADW70093"/>
        <property type="gene ID" value="AciX9_3073"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3073"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082109_0_0_0"/>
    <dbReference type="OMA" id="AYGCADF"/>
    <dbReference type="OrthoDB" id="1517743at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="29137" checksum="F05562157DDB4805" modified="2011-04-05" version="1">MGFFLNGNALLALAAAGLWGVGDFSGGMGAKSAGGNTASALRVVLLSHLTSFSVLLLILFARGDTFPHGAPMLWGIAAGVAGGLSLTGFYIALARGAMGASAAISGLLAAAIPALVSMLTDGSPGLRRALGFLIAGAAIWLIAAGPAEHEDPSTTWLAIASGAGFGFYFVALKYAGPAGPVWPMALARMGSISTCSIILLALRGGGGAVTITRRTILWVLSTALFDTSGNLLFVAAARLGRLDVAAVLASLYPASTILLAAWVLRERPTRRQAFGMAVAIAAVVLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C0</accession>
    <name>E8X0C0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581415.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3081"/>
    <dbReference type="EnsemblBacteria" id="ADW70101">
        <property type="protein sequence ID" value="ADW70101"/>
        <property type="gene ID" value="AciX9_3081"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3081"/>
    <dbReference type="eggNOG" id="ENOG5033BCD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608527_0_0_0"/>
    <dbReference type="OMA" id="THGSEAQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234034" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="18296" checksum="47F4492C11A4B7A5" modified="2011-04-05" version="1">MRLILPTACLLLAATFQAQTTIPQLHATTFAGDPVTLPGPPAILILGFSQASRTQASDWGHRLAADPHRPPTVAYYELPVLESVPRLIRSWVLKRIRQSVSPNGQHHFAPILDHEQDWKRATAFDNPDSAYILVVDPSGTVRWHTAQPLTDQTYAEALRQAALIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D8</accession>
    <name>E8X0D8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0732</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579128.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0732"/>
    <dbReference type="EnsemblBacteria" id="ADW67802">
        <property type="protein sequence ID" value="ADW67802"/>
        <property type="gene ID" value="AciX9_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0732"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945827_0_0_0"/>
    <dbReference type="OMA" id="DEPRYRI"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="212"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="294" mass="31544" checksum="6E61C903BAC4DC87" modified="2011-04-05" version="1">MGLTLPFICRIAALTLLLPGFAVLRASAQTVPPLASASTASDPRLAAAELLIGRALFLRGFYGASELSYDASGHVQGAPPRMDWTLTGFDLQAVTQPKADVLLLNGIRVAIRYNPDAHTFDRHPLKGEAVHIQIAEAETVQALKTTLAAIFSTGIDPALQRSTPEFWRHYFEPSLAWSKDAASPDSLLDTPVLGVGGKLPPNVSAPVPDSQPRPDYTSAARQDRVQGTVVLRVVVGVDGSPHRITIVRPLGYGLDAKAAEALSHWHFRPGMQDGKSVAVEMTVNQEFSLATPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L0</accession>
    <name>E8X0L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580280.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1915"/>
    <dbReference type="EnsemblBacteria" id="ADW68961">
        <property type="protein sequence ID" value="ADW68961"/>
        <property type="gene ID" value="AciX9_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1915"/>
    <dbReference type="eggNOG" id="COG4846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112887_0_0_0"/>
    <dbReference type="OMA" id="MFWILAF"/>
    <dbReference type="OrthoDB" id="1851222at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031306">
        <property type="entry name" value="CcdC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39164">
        <property type="entry name" value="PTHR39164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07301">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021441">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17646" checksum="BA44ECC69CE763CA" modified="2011-04-05" version="1">MLPSHWLTPGVSAAAAILGFFAVLAWRIQEGRSAVTLRKIVIPPLGMATGFCMFIAPSFRVPWLWAAASFLLGAILLAYPLIKTSRLTLVGDTVMVHRSNSFFAVLIALGIIRILAHTYLDRVMSLQQTAGLFFILAFGMILRWRTSMFFEYHRVTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P2</accession>
    <name>E8X0P2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SF4 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580312.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1947"/>
    <dbReference type="EnsemblBacteria" id="ADW68993">
        <property type="protein sequence ID" value="ADW68993"/>
        <property type="gene ID" value="AciX9_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1947"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561146_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="209"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="486" mass="54310" checksum="80364939AEF51A9F" modified="2011-04-05" version="1">MDDFSLEFAHLFHCLLRHDHSEAEKDRAAGVVAWAGNNLINLRACCVNDELTLVGIVWDFAYKQHSLPTLDSVNDAVALLDKSAEVVALINNYREIRSELVPHDALGMGPVLAAKIVAFERAKLGLYLRQAVMINGGTAKEDKRLGRRYEGPKGALNYIMDKLEEGILIDRTGVVQPIIVQKEAGELGERYDYLKSRGHLPSGIDALPLYPGDLCGILGYSGGGKSTLGRFIVYQMAAMADKNILVISLENDAEVERDKYLLLHCHHPKWGGEFDAISYERFLTGALLPVERKALDLIAQDFADTVSGRITILQPSDSTWESLKHLVELHSSRHQLDVLFIDYLQMLESRSTRGEDTRSQMTRMIKDVRRFGLTHRTLSGHPMVIISPIQGNEAGKKFAEDHEGRWDLSGVNDVKEMSRSCTQLVGTFTYGDHDPQGNLEGVISCVKSRDGIYWGQVPYKQTCAGWIHTDRIAHNEITLDDILDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0P7</accession>
    <name>E8X0P7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1952</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580317.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1952"/>
    <dbReference type="EnsemblBacteria" id="ADW68998">
        <property type="protein sequence ID" value="ADW68998"/>
        <property type="gene ID" value="AciX9_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1952"/>
    <dbReference type="HOGENOM" id="CLU_1832345_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="140" mass="14508" checksum="665986C98956493D" modified="2011-04-05" version="1">MTNTSAIVETFLTQMGEQATVLVNRIAELDTEKATLQGELTKINHALAVWNGKETPDGKSAPGTRKKMSEAGRANIAAALQARSARLRAEKEAAGGKDAEAVAVPSAAEEKQSEPVQEATPTPKSTPAKKAAAKGGKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R0</accession>
    <name>E8X0R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1965</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580330.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1965"/>
    <dbReference type="EnsemblBacteria" id="ADW69011">
        <property type="protein sequence ID" value="ADW69011"/>
        <property type="gene ID" value="AciX9_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1965"/>
    <dbReference type="HOGENOM" id="CLU_2023448_0_0_0"/>
    <dbReference type="OrthoDB" id="13902at57723"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021508">
        <property type="entry name" value="Gp17-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11367">
        <property type="entry name" value="DUF3168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13654" checksum="010EBD23EA2F7BF8" modified="2011-04-05" version="1">MVETTIYTILSTSPAVTALVSDRINPMVLDRDTGFPAISYLFISTVSSPTFSTRGSQRYRFEVSCWAQKALSAWELRAAVITALNGYSQDGVVIQFMLSRDMFDHISETCRATAEFYVFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y5</accession>
    <name>E8X0Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3158</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581482.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3158"/>
    <dbReference type="EnsemblBacteria" id="ADW70169">
        <property type="protein sequence ID" value="ADW70169"/>
        <property type="gene ID" value="AciX9_3158"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3158"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484645_0_0_0"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="559" mass="62964" checksum="25EAC57E23B9F5C8" modified="2011-04-05" version="1">MQDSSPFQYIAIDQLFESKTNPRQTFDQTKLEELAASIKHHGLIQPIVVRPKDNGFEVVAGARRYRASLLAEEFSVPAHIKELNDAEAIEWQLVENSQRVDVHPYEEAQGFQRLLDVPGYDVAALVEKSGKSASHIYARLSLLQLIPKVAEAFVQERITASHANLIARLPQEHQADAFENCWRKDWQDKEAHLLPAKHLSAWIQNNLYLNLADAPFDREDPTLKPEAGACVTCPRRSGFNTSLFAGVQGDQCLDGACFQAKVTAHIDREVATRPELVQIETAWRSPKEQRSGTLNKNQYRELAEPDNPDAEPPCPNAKAAIIVFGKNVGRTVTVCLEDECAVHTNHAHHADEDVEPPPVMAEAPEEETEEEAAQRKAEHERQMAEYHAEQGRKEEERKAEFERQQKQYEADQARREKLRKARLATFERIVEEAPATFSPEQQRMFLRLLVNINPYEFLEEVASHFSGEENEERSKDQIVLHALSNTADGKLNGFALRIVLTEHVGIPRENELDFLTEAENVFAPKKPKAVKPNRAPAKKAKPVAVKAASKNTDSAKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X132</accession>
    <name>E8X132_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0830</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579223.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0830"/>
    <dbReference type="EnsemblBacteria" id="ADW67898">
        <property type="protein sequence ID" value="ADW67898"/>
        <property type="gene ID" value="AciX9_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0830"/>
    <dbReference type="eggNOG" id="COG4301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049766_1_0_0"/>
    <dbReference type="OMA" id="RVEMHLV"/>
    <dbReference type="OrthoDB" id="775492at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="3">
        <location>
            <begin position="14"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="328" mass="35594" checksum="0B118B5B41ED8347" modified="2011-04-05" version="1">MPTQELIASNPVSEAAREGLLAARKTLPPWLFYDERGSRLFEQITLLPEYYLTRTERAILATHAPEIVSSLGAPITLAELGAGTATKTGLLLAAAARIQPTVLYQPIDVSPSALDEAVHNLQRDIPGVNVRPQVANYITEPIRITRPTKHTRILALYIGSSIGNFSPAEARGILLNLRAQLAPGDALLLGTDLAPGPNKSEAALIAAYDDAQGVTAAFNRNILTHLNRELGTNFIPGCFHHRALWNPTESRMEMHLESKRPQSVTIPADPSGPAQTIHFERGETIHTENSHKFTPATIASLLATANFTPTHTYHDPNHLFAVTLATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G1</accession>
    <name>E8X1G1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3185</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581508.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3185"/>
    <dbReference type="EnsemblBacteria" id="ADW70196">
        <property type="protein sequence ID" value="ADW70196"/>
        <property type="gene ID" value="AciX9_3185"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3185"/>
    <dbReference type="eggNOG" id="ENOG502ZBD3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061446_0_0_0"/>
    <dbReference type="OMA" id="FGETNGM"/>
    <dbReference type="OrthoDB" id="1099024at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="28281" checksum="7E4B3E9F0D03B02C" modified="2011-04-05" version="1">MKIQLKHPRRWLIGGALLLLTATPSFALFGIGDIVFDPTSYASLVSQLTTIESQYKMLQNNIEHFSLKQQWQTTLTALKNVNVANMFGETNGMTVAFNTNSSSASTTAWKTATTPVSSNVTTYFSGQTVGSPQMSQLAMVEMSDSISPDCITAVGAYRAARTQNTTANSSLMANQLDGTSTTNSEVQQLNLLNAAEAQKMSEMQNQGAMQACLASQMAVQNMERRNAAATDLNTAAFVQQQRSTNDVSASNESNTWQTYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H0</accession>
    <name>E8X1H0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3194</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581517.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3194"/>
    <dbReference type="EnsemblBacteria" id="ADW70205">
        <property type="protein sequence ID" value="ADW70205"/>
        <property type="gene ID" value="AciX9_3194"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3194"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="SNQRRWW"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="223" mass="24641" checksum="37A76EC747B7CC62" modified="2011-04-05" version="1">MQAGTLVNHLASAVGVRTEDAALVAALKSGSEEAFGVLIAQYGQPLYSLIARSLKDPADAADITQEVFIKVFRSIRTFNGEASLRTWLYRIALHEASNQRRWWSRHKKQELTIDAPLTSGSQEDLDEGLCLSATLADQAGSPYEQAVNTQLRARVEESLRKLPEAFRTVVVLREMEGFSYDEIAEILEVPAGTVKSRLTRGRSALKEILVQDGLGRVLAERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J7</accession>
    <name>E8X1J7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">AciX9_3221</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="14"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581544.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3221"/>
    <dbReference type="EnsemblBacteria" id="ADW70232">
        <property type="protein sequence ID" value="ADW70232"/>
        <property type="gene ID" value="AciX9_3221"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3221"/>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_0"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="OrthoDB" id="1064872at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="15">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="16">
        <location>
            <begin position="186"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 13">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="38747" checksum="6FFF6346FFA0463B" modified="2011-04-05" version="1">MLSNSRTQPHRRYNPLRRQWVLVSPQRTARPWQGQLNKPVAPDQQPYDPTCYLCPGNPRTSGDVNPQYPGVFAFDNDFPALLPPSATDLPAEHNGLLIAEPENGRCRVLCFHPNHSLTLSQMTPPDIEAVINVWAHETLVLGSDLAIQYVQIFENRGAMMGSSNPHPHCQIWATGHIPEEPAAEAESQLAHFQQHNRTLLADYLTQELKEKVRIVSENETFVAVVPFWAVWPFETLILPRDPIASFVDLTPAQTTGLADILKRVTTRYDNLFGVSFPYTMGFHQAPTDGEPHPEIHFHAHFYPPLLRSAEIRKFMVGFEMLGMPQRDITPEKAAEMLRAAPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U6</accession>
    <name>E8X1U6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580424.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2062"/>
    <dbReference type="EnsemblBacteria" id="ADW69107">
        <property type="protein sequence ID" value="ADW69107"/>
        <property type="gene ID" value="AciX9_2062"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2062"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_2_0_0"/>
    <dbReference type="OMA" id="HFKGQDV"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="209" mass="22277" checksum="9360F02C3DD5C17D" modified="2011-04-05" version="1">MKVLVIGAGGKSGRLVVEKALAVGHEVVALVHSAESEEKHPMPAGAEVFHGDVRNPSKLEAAMAGCQGVVDAIGGTKPFLETTMERDAAKVVLEVMGKVGAKRLVVISVMGVGESRESAGWFYDHLLLPVFLRGALPDKTAMEDEVKHSDVDWVLVRPPVLKDSDETGVVRVLGQGELAESITRGDLARFLVEQLTSEEFVGRAVTVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A1</accession>
    <name>E8X2A1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0966</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579357.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0966"/>
    <dbReference type="EnsemblBacteria" id="ADW68033">
        <property type="protein sequence ID" value="ADW68033"/>
        <property type="gene ID" value="AciX9_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0966"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_0_0_0"/>
    <dbReference type="OMA" id="MSHFFDL"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="727" mass="80616" checksum="DBC367F4940CE180" modified="2011-04-05" version="1">MTSDPSKPHFSILATSFAGGPRPRNAALILSGLWLLIFCTSLFTPPLLDDADATHAQAARAMLATGDYVTLHVDGIRYLEKAPLPYWITALSLRLFGFNTFAAHLPLALAVALLVLLGHRWANQAFGARTAFYTSIATLTSFGIFLFTRILIPEVLLSLFLCTALFAFLKSLEPSPLNENNRVPHVPTLGRGLEPAQTSPETERPSIAWYAGPHFYPYVMWSVLALAVLTKGLVALLFFFATTIAYLTLTATWSDWCRLKPFTGLLIFFAIAAPWHILAALSNPATADHQGFLWFYFWNEHVLRFLGRRFPHDYNKLPGYAFWLQHLVWLFPWSLFLPLGITALNRRYRHQVETLTGYIQVSATAKTFLIVCIALGVGAILEVARAFRLDSFTAGALIVLIFCIFWIVTRRQRADLPQSPFHRIDPQQRSILLLSLFAAIVLLFFSLSTNQEYYTFPAYLPILLLIAATITRAEQTYSTNPEARRWITFAHASLTALGTIAALALCFGLWTSRHLPYNPDIGTLLAHRNVGGYTLATSHLYDLTGSAFAALRLPAVLAALALLLGPLLAWHLRMQRRHLAATTTISFTAAAFLFSANLALARFAPLLSSADMAQTIQHLEHTGKITPDTQIFLYGDQALGSSIPFYLGHPVELVEGRSTSLLFGSTFPDAPHLFLSNADLTAQWGQGPRKILFVPAELQSKLPHLSGAFLLQQTSGKQLLTDRPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2C9</accession>
    <name>E8X2C9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">AciX9_0994</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579385.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0994"/>
    <dbReference type="EnsemblBacteria" id="ADW68061">
        <property type="protein sequence ID" value="ADW68061"/>
        <property type="gene ID" value="AciX9_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0994"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_1_2_0"/>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW68061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="373" mass="40093" checksum="ABADC9255BD04ADB" modified="2011-04-05" version="1">MSQDQQFMQRALELAESTTALASPNPQVGCVFVRDGKIIAEGFHLYEARDHAEIAALKQAEANGIDVAGDTAYVTLEPCSHHGRTGPCADVLIAAGISRCVIATLDANPVVRGNGVAKLEAAGIAVTVGVLEQKARTLNDAFAWSIRHNLPMVTLKAALSVDGKLAPPPSQRQRPEPHWLTGPESRAEVQRLRHASDAILTGIGTVLADDPTLTDRTGLPRRRPLQRIILDAHLRIPVASKLVESAADDLLIFCNQNAPQDRLTALEAAGAEIHQVPGTDRLDLRAILSTLHERKLLSVLLEAGPSLNGAFLAAHLVQRAILFYADTELGEGALPFAEDLTNPHLLEQTMTHVTRTTFGPDGCVSGLLQNPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2D5</accession>
    <name>E8X2D5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TniB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1001</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579390.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1001"/>
    <dbReference type="EnsemblBacteria" id="ADW68067">
        <property type="protein sequence ID" value="ADW68067"/>
        <property type="gene ID" value="AciX9_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1001"/>
    <dbReference type="eggNOG" id="COG1474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067529_2_0_0"/>
    <dbReference type="OMA" id="PQHASRF"/>
    <dbReference type="OrthoDB" id="471286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008868">
        <property type="entry name" value="TniB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05621">
        <property type="entry name" value="TniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="33447" checksum="5407276126094073" modified="2011-04-05" version="1">MSEHLSSSAKAALMLSDTERIRYARNEQFISYTGAKRILTSLENLLDHPKRQRMPCLLIAGRTNNGKSAIAQEFLSLHPPVKEPSADADVVPVLYVQAPPVPDERRLNAVLLDKLCVPHKTNERADRMMQQLLVVMPNLGVKMLMIDEIHHILAGNRERQRVFLQVLKYISNELQIPIVALGTDNALFALQADAQLANRFVPIAIPEWKHNLEYLGLLKAFEKLLPLRLPSMLTDAQLATRLLTMCEGTIGELARLLSIATEEAIRNQSERISVALLERLSWVQPSERRNFVAREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N4</accession>
    <name>E8X2N4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative terminase small subunit, Nu1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581643.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3322"/>
    <dbReference type="EnsemblBacteria" id="ADW70331">
        <property type="protein sequence ID" value="ADW70331"/>
        <property type="gene ID" value="AciX9_3322"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3322"/>
    <dbReference type="eggNOG" id="COG4220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432712_0_0_0"/>
    <dbReference type="OrthoDB" id="1945478at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20917" checksum="CA9302F23A58488A" modified="2011-04-05" version="1">MKEQRLVSVTEIRTILAGKGHPMLSKQAITNFVKDGMPKRALGKYDRDECLAWYVGRLRTNVLKQETESRDGQVISLDKARARLVVAQAENEEMTALERKGKLIPLELYETEGSRWALLIKTNLLNLPSRLGPNLVGLTAPEIKALLNASMVEFLARLVKVGPGSPAKQSEVGAEARKTLPSTTKRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P3</accession>
    <name>E8X2P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3331</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581652.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3331"/>
    <dbReference type="EnsemblBacteria" id="ADW70340">
        <property type="protein sequence ID" value="ADW70340"/>
        <property type="gene ID" value="AciX9_3331"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3331"/>
    <dbReference type="HOGENOM" id="CLU_2861459_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7297" checksum="079128FBBC052F5A" modified="2011-04-05" version="1">MAKKSSAGEQEPAALQGAVESVIMSLRVDKPQHDRLRKLAFDKRIPMREFIVRGIEEVLKAEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S2</accession>
    <name>E8X2S2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor, CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581681.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3361"/>
    <dbReference type="EnsemblBacteria" id="ADW70369">
        <property type="protein sequence ID" value="ADW70369"/>
        <property type="gene ID" value="AciX9_3361"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3361"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_2_0"/>
    <dbReference type="OMA" id="RIMETLW"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="122" mass="13919" checksum="6F8EB5FE0A30D819" modified="2011-04-05" version="1">MDKRIAKSELQLLEQMWKLGPSSVREIHESLSEENRLAYTTVQTMLVRLEEKNAVRRVKKIGNALIFEAVFTREAVHRRLIRDLLDLFGGSAKPVISHLVESGDLSLADIRAIEKQLKRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X331</accession>
    <name>E8X331_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2211</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2211"/>
    <dbReference type="EnsemblBacteria" id="ADW69255">
        <property type="protein sequence ID" value="ADW69255"/>
        <property type="gene ID" value="AciX9_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2211"/>
    <dbReference type="eggNOG" id="ENOG5033K84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433963_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="23052" checksum="899B5D81253DED88" modified="2011-04-05" version="1">MSTKILMSFAMANQGAAFANWLRDKLMKHYSLYAVDDVYMDSVVARSGNTRHATFREDFVGDAPAGTASVTPDRRDHMRSPTGAMPIGAARADWNTLYKNAMREAQIMLFVYTEEYNDSVYCMQELGQFHMENGRRRRAHLPILRGVVLQFNPGNLFGMNQTHVTRIPVTRTNGMRMGLAWDHGDFILSPPHLQLLTTTLGPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C5</accession>
    <name>E8X3C5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3420</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581738.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3420"/>
    <dbReference type="EnsemblBacteria" id="ADW70426">
        <property type="protein sequence ID" value="ADW70426"/>
        <property type="gene ID" value="AciX9_3420"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3420"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_0"/>
    <dbReference type="OMA" id="SFEVWAA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="295"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="56440" checksum="7AE9AAF24BC76B6F" modified="2011-04-05" version="1">MIQAKERQLLYVDDTEEQRYVMRRILEQAGFTVIEAGTGTEALQKLHPGILAVILDVKLPDMSGYEVCRRIKSSPATAAMPVLQISASFADPTLRAQGLSGGADAYVAQPVHPAELLSLVNALIRSHDSEKTLRFQAEIGSRLSESLDYAKVFNCVEEVFVPRFADHCFIVLQRSAGAHAATDNVRTAPPDTPGLPADLHAVAIEVIDNGQSRFLNRYTIAVPLEVGRMRLGALVFTLDPDHRHYSPTNLSLAEDLADRAALALQNAALYSAQQTAQKALIQSEKLAAAGRLSAAIAHEINNPLEAITNLMYLIDTSEEITPTLKGYVQEALSELSRLTHIARQSLGFYRELTGAALFDLNESVDDTLNIYLKRFDAKHIHVERHYHPGPLQLSAVKGEVRQVVSNLLVNAYDALPTNGCLTVSTDTSTDAEGLTDLVILRVTDNGSGIPPNVVAHIFEPFFTTKEGTGTGLGLWVSDTIVTKHGGTIKVMSRTEGDDHGTTFEVSLPVKPAHTDQPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E6</accession>
    <name>E8X3E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581758.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3442"/>
    <dbReference type="EnsemblBacteria" id="ADW70447">
        <property type="protein sequence ID" value="ADW70447"/>
        <property type="gene ID" value="AciX9_3442"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3442"/>
    <dbReference type="eggNOG" id="COG5654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133611_0_1_0"/>
    <dbReference type="OMA" id="MELWRIS"/>
    <dbReference type="OrthoDB" id="1821714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16903" checksum="4C8C6A7D20E6E1EF" modified="2011-04-05" version="1">MLFWRISNYATLDGAGGLYVSGRWHTRGRPVVYCTWHPSTALLETLVHLEIDAEDRPANFQLLRIESPKGLSLERLEESGLPANWRADPTATQRQGDAWLASRRTLLLEVPSALLPETWNLIVNPLHPQAPELRITKIYNRPFDPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H7</accession>
    <name>E8X3H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1105</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579491.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1105"/>
    <dbReference type="EnsemblBacteria" id="ADW68168">
        <property type="protein sequence ID" value="ADW68168"/>
        <property type="gene ID" value="AciX9_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1105"/>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144805_3_0_0"/>
    <dbReference type="OMA" id="DEEWENG"/>
    <dbReference type="OrthoDB" id="1897062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022789">
        <property type="entry name" value="ParD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03693">
        <property type="entry name" value="ParD_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9740" checksum="F5F8DF782CF284D9" modified="2011-04-05" version="1">MANTISITLPDSIKAYVDAQIEAGFFGNLSDYFRELALDDRDRHLARLEDRLVEAIKSEPITFTDEEWENGDLIALGRERLARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U8</accession>
    <name>E8X3U8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar hook-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2339</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580692.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2339"/>
    <dbReference type="EnsemblBacteria" id="ADW69376">
        <property type="protein sequence ID" value="ADW69376"/>
        <property type="gene ID" value="AciX9_2339"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2339"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024437_2_2_0"/>
    <dbReference type="OMA" id="MRVTQGM"/>
    <dbReference type="OrthoDB" id="1788350at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="4">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="30565" checksum="A654670E149D3F7C" modified="2011-04-05" version="1">MRVDPNYVFNLTQSVSASSAAEQKLTNQLSSGLRVSSLSDDPVAVAQNVLLASSISKADSFTQTSTREQAVLQATDSALGEVVSNVTSAITLSVQANAGTLSASNLKSIGEQLSGIRDQVVSLANTGYLGTYLFGGSQGGTPPFTLATSTDPATVTYNGDSVTQSVVTPDQQKIQVNLPGSAIFQASGADLLGALNQVVSDVSNGASGTALASDTAALTTALGNVTSQRAVLGSSLSRLTSTTTYSNTQEAQLTAQQSTLLSSDTAAVATGLTTAETQHTALLNVIAGLDKTNLFDYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V1</accession>
    <name>E8X3V1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2342</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580695.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2342"/>
    <dbReference type="EnsemblBacteria" id="ADW69379">
        <property type="protein sequence ID" value="ADW69379"/>
        <property type="gene ID" value="AciX9_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2342"/>
    <dbReference type="eggNOG" id="COG2747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2342810_0_0_0"/>
    <dbReference type="OrthoDB" id="14374at57723"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="8">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="9698" checksum="ED08BAA7BB1C4EEA" modified="2011-04-05" version="1">MQQTNGINSLQNSTGSLAVNGSNAVQTPKSLNSSGGTAASPQQKTDKASFSDAASSVTRSSDVRLAKVAGIQQAIANGTYNVSAGQVADKIISSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Z1</accession>
    <name>E8X3Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine monophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3494"/>
    <dbReference type="EnsemblBacteria" id="ADW70499">
        <property type="protein sequence ID" value="ADW70499"/>
        <property type="gene ID" value="AciX9_3494"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3494"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_4_0"/>
    <dbReference type="OMA" id="EVDFIHI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="21858" checksum="F87DB6514F02C9C2" modified="2011-04-05" version="1">MTQAVHCQRRFIRPKLDSMLRYAITDRFLLGKGDTGRLIERCGALAQTGIDFILVREKDLPAGELVQLCRQIAAAAQGSATQILVSSRVDVALAAGVAGVHLSSQPGELTPAQVRQLMPSAFISVSCHSLEEIRRARLGGASAALFAPVFGKTIQGQEVSAAIGLDALRAACAEAAPMPVFALGGVTNENAASCGAAGAAGIAGIRIFYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X402</accession>
    <name>E8X402_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3505</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581821.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3505"/>
    <dbReference type="EnsemblBacteria" id="ADW70510">
        <property type="protein sequence ID" value="ADW70510"/>
        <property type="gene ID" value="AciX9_3505"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3505"/>
    <dbReference type="HOGENOM" id="CLU_1480065_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="182" mass="18401" checksum="6BB299BC057D8CF7" modified="2011-04-05" version="1">MDTLLNDIFHAQPYALLIIAGLVFITIAIVGSIKTYIDPGKAGRIAAGAAGAVLLCAGLFMSKSAPATASAPPAVPKVEAATHGGESSAPAAGTLGKPTTACYVQGHWPTDIHKQMAAGDTCTLPDGLAGKAVLANNVCNYTSGPLNGTSAQFNNLMYVGYSCTSPDKQSKGQVPAPVATQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X496</accession>
    <name>E8X496_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0065</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578485.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0065"/>
    <dbReference type="EnsemblBacteria" id="ADW67156">
        <property type="protein sequence ID" value="ADW67156"/>
        <property type="gene ID" value="AciX9_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0065"/>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_5_0"/>
    <dbReference type="OMA" id="RTVAAWY"/>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="58"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="239" mass="26779" checksum="5CFE26B60C4D7108" modified="2011-04-05" version="1">MPRILARPRPPTYDSARAVRELTAADPKLGRLMERAGPYTLKLASTQSPFEALLVSIIYQQLHGKAAAAIHTRLLESFGHVLTLEGKMLGDHPSPQHLLDCPNEQLRAAGLSHNKALSVRDLAAKTIEGTVPSMARIRRMTDEDVIEHLTQVRGIGRWTVEMFLMFRLGRPDVLPLGDYGVRKGFALTFQGLKPTQKVTPDLLATPEAMLKRAKRWHPWCSIASWYMWRACDLAKPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L5</accession>
    <name>E8X4L5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580741.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2388"/>
    <dbReference type="EnsemblBacteria" id="ADW69425">
        <property type="protein sequence ID" value="ADW69425"/>
        <property type="gene ID" value="AciX9_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2388"/>
    <dbReference type="eggNOG" id="ENOG50330AH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101709_1_1_0"/>
    <dbReference type="OMA" id="VKYQADY"/>
    <dbReference type="OrthoDB" id="1400203at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="17155" checksum="58DC345B2F3C0DDF" modified="2011-04-05" version="1">MIRFVTTCVLSLSGVAALGQSGAQSVDVPAGFHAVLTAEGRGVQIYKCQKKDAGMAWVFVAPEAKLFVDGVEVGSHGAGPVWMYKDGSSVHGKVVSNMSSPVAGAVPWLLLKGVDAAGAGEMAGVAYIRRSETKGGVARVDGCDVAHEGAESRVPYTATYSFYAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U5</accession>
    <name>E8X4U5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3580</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581895.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3580"/>
    <dbReference type="EnsemblBacteria" id="ADW70584">
        <property type="protein sequence ID" value="ADW70584"/>
        <property type="gene ID" value="AciX9_3580"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3580"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_0"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="371" mass="41165" checksum="699EEC46D9C6EF44" modified="2011-04-05" version="1">MPSKNMIPKGQRHHTVRPQYVAERFAEPVEPLVVPTVEFEDDGEDAIRSFPADVAAAGMRLDAYLAQALPDISRARVQILIEAGQVKVDGAVPKAKAKLKGGETIEIEGQPQLEPLHAIPEDIPLQIVYEDEYLAVVNKPAGMMVHAGAGSTDDERNRGTLVNAVLFHMGKTADSLSGVGGELRPGIVHRLDKQTSGLIVVAKDDVTHRRLGEMFSERRVSKTYLTLAHGELKKADTTVSLPIARDLVRRIRMTTRRGDGRSAVSHFHVLERLDTPYGKFTFVEVKIETGRTHQIRVHLQSLGHPVVGDTLYGAPHVVRLTKEPNVEPLELERNFLHAARLAFVHPRTEEEMEFEAPLAEELVEFLEKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U8</accession>
    <name>E8X4U8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3583</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581898.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3583"/>
    <dbReference type="EnsemblBacteria" id="ADW70587">
        <property type="protein sequence ID" value="ADW70587"/>
        <property type="gene ID" value="AciX9_3583"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3583"/>
    <dbReference type="eggNOG" id="ENOG503474K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182183_0_0_0"/>
    <dbReference type="OMA" id="TMNQERD"/>
    <dbReference type="OrthoDB" id="2066340at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9939" checksum="BF2F6FC9B0626736" modified="2011-04-05" version="1">MNDNSNVSVSADEFQALEQKVLRAVEIVKRERELRAAAEAEAASLREQITALTSMSDEAQTQISTMNQERDAVRLRVEKMMSQIDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U9</accession>
    <name>E8X4U9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="11">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="11">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pheT</name>
        <name evidence="14" type="ordered locus">AciX9_3584</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581899.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3584"/>
    <dbReference type="EnsemblBacteria" id="ADW70588">
        <property type="protein sequence ID" value="ADW70588"/>
        <property type="gene ID" value="AciX9_3584"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3584"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_0"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="13">
        <location>
            <begin position="298"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="12">
        <location>
            <begin position="599"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="693" mass="74117" checksum="0C20CEE021DE7FAB" modified="2011-04-05" version="1">MKILTPWLRSYLPVLAVDDAQLAEDLTLRGIAVEGVFEVNDASGDSEGSVFDMDITTNRVDAMNHYGMAREVAAIYDLPLHALDVSLPDAGAAETAFPVRIEAQDLCGRFTARVLRGVTVAPTDGVIGGYFDSLGLKKISNAVDVTNYVLQGMGHPTHAFDLDKIEGGIVVRRAKAGEQIKLLDGTTRTLVVDDLVVADEVKALGLAGVMGGWDSMITAETKNVLVEAAWFQPATIRASSRRHLIHTDASHRFERGADFAAAPIANALVSKLILEACGGRVEGELIDVVVAEHEAATANRGTVALSVTEARRHLGTTVEPDGINAEVIHRYLTALGCTLTPVSVDGYEVRLPSWRLDLTREIDLIEEIARVYGYNGFANTLPTPGVVIDHPTARAERAVRERLLALGYSEALSSTFASAAESAQFAAGVAAVELENPLNEEAANLRPSLLPGMVTMLAHNLNRDVLNVRLFETGAVFSGGTAEVSEAMSLSLGITGVSPVSNLYLAADASFYELKGAVESLVGLFAAPGLTFAAEASPVFEAGRAAAASVNGKVVAQFGQLAASEGAKRKMRQPVYVATVDLAALLAMPLKHTTAKELSRFQAVERDFSFVFANSVTWGDVEGAIRSLKIAELQSLRPIEVFRDEKKWPGVYSTLMRTVFQSLDRTLTDEDVTGWWSAIISALQGLGGVIRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X535</accession>
    <name>E8X535_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetate kinase</fullName>
            <ecNumber evidence="3">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ackA</name>
        <name evidence="5" type="ordered locus">AciX9_0152</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578555.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0152"/>
    <dbReference type="EnsemblBacteria" id="ADW67227">
        <property type="protein sequence ID" value="ADW67227"/>
        <property type="gene ID" value="AciX9_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0152"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_0"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="405" mass="44180" checksum="B45ABDB5E8FEAA38" modified="2011-04-05" version="1">MADALVFNPGSNSLKFEVVRLTDNQRFAGEATKRITAAIEEFGDEATLSVFDPSRPRQLAHSEKVKAPDMKAATDFALRWLKDQKVSADSLAFTAVRVVHGGVKYDGATRVTDEVLHDIEALEELAPLHNESSLQILGVLAQRLPDTPAYVTFDTAFHRTLPEEAWRYPIEREAADRHGIRKFGFHGLSHRFMVEQYARTVGKPLGEVSVVTLHLESGCSASAIVKGRSVDTTMGLTPLEGLMMGSRSGSIDPAIIPYLMHKEKQTVEEVMKLLNKRSGMLGIAGGTLDTRVLEKRDDEAARLALRMFSYRVRLAVGAYLAAVGDAQAVLFGGGIGEDSPWLRAGVCEGLRGWGLELDPALNRSTEGQVVVSTPASRLQAWAMPVEEGLQMAHECQLSIKNAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X547</accession>
    <name>E8X547_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1249</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1249"/>
    <dbReference type="EnsemblBacteria" id="ADW68311">
        <property type="protein sequence ID" value="ADW68311"/>
        <property type="gene ID" value="AciX9_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1249"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690319_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="160"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="42291" checksum="3EDD658EB48F9F63" modified="2011-04-05" version="1">MQKSPIRIIVASVILVAVVAWLAISGAQANKSYYVTISELQGMGGKAYTRHLRVAGNVKAGSIQRVGTSAHFTLMEQGKALQVAYQGSEPPPDAFKDDAQALAIGTYGRDGVFHATALQAKCASKYAPAPGARPPAATASVVPPPPSRQPVSVTTPAAAAELHNVSKIFGTFAAVRNATLTLPAGTATVILGENGAGKSTVLRLLAGLTEPTQGTLKVLGDFPQLQRGRVAYMSHAPMLYDELTAMENLNYFAQLHMGPGACACQGSPEMALRSVGLDPHLKRPVGQYSQGMRQRTSLARVLQTDPELLLLDEPFSNLDVASASAMVELLADFLTWPHHTPGARRTIVLTTHQHHLAEPLAHLTLTMRQGTIVSQVSTNESRVPHPREARVGSNAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C1</accession>
    <name>E8X5C1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2432</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580784.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2432"/>
    <dbReference type="EnsemblBacteria" id="ADW69468">
        <property type="protein sequence ID" value="ADW69468"/>
        <property type="gene ID" value="AciX9_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2432"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_0"/>
    <dbReference type="OMA" id="WADENYG"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="426" mass="46281" checksum="4EF219F35DF7A5E4" modified="2011-04-05" version="1">MKEVDFAFGKDGIQVKLHEGPSYMLVESRSAQPLADPLQALDHALDFPVAGPSLLTLAEGKKTAAISICDITRPAPNWMTLPPLLKRLHAAGIPVEGVTILIATGLHRPATTDEIRRIVGEDIAAKYRIVNHDAKDFDQHLSLGTTSRGTPVYIDSRFMQADLHITLGFIEQHLMLGFSGGRKLVAPGVASQETIKVIHSPRFMREPNATEGHTSDNPLHLELLEIARMVRHDFMLDVTLTKTREISGVFAGEPVQAHAAGVRFLQHTSLEKLPKLADVVITSAAGYPLDLTFYQIVKGITAAQHIAKPGGKILILAECSEGAGSPEFAHKLENYPGHQQFLDEVHTAKVEVDQWQLEKLALTGLTHELYFFTPGVPAAHAGALRDRVFTSVDLAVDAVLSDLTPGADVALIPEGPYVYARVDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E3</accession>
    <name>E8X5E3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2455</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580806.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2455"/>
    <dbReference type="EnsemblBacteria" id="ADW69490">
        <property type="protein sequence ID" value="ADW69490"/>
        <property type="gene ID" value="AciX9_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2455"/>
    <dbReference type="eggNOG" id="ENOG502ZC5H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087546_0_0_0"/>
    <dbReference type="OMA" id="WKFTAEI"/>
    <dbReference type="OrthoDB" id="1682012at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="219" mass="23566" checksum="309B34695B0FA610" modified="2011-04-05" version="1">MGFPGSPRLLRAGLVVVDSSTLAIQRSIALQYNPDSLSRSLAVRGATGDSGDRLDALRLTGPPVETLKLDAELDATDELETPSKFPDTVRLGLHPQLAALETLIYPSSAQIQSDNTLAMAGTIEIAPMEAPLVLFVWSTSRVVPVRITEFSITEEAFDVNLNPIRAKVSLGMRVLSTNDLNFDHKGNHIFLAYQQNKERLAGKVGSVSLRSLGITGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I3</accession>
    <name>E8X5I3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2498</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580846.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2498"/>
    <dbReference type="EnsemblBacteria" id="ADW69530">
        <property type="protein sequence ID" value="ADW69530"/>
        <property type="gene ID" value="AciX9_2498"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2498"/>
    <dbReference type="eggNOG" id="COG3678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1395710_0_0_0"/>
    <dbReference type="OMA" id="GRWWDDK"/>
    <dbReference type="OrthoDB" id="2061587at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230244" evidence="2">
        <location>
            <begin position="30"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="206" mass="21022" checksum="ACF0E091E53C7253" modified="2011-04-05" version="1">MQSGWKKKMLMLSGCSLLVMLLAGGVALAQGHGGGGGGQGGGGGQGGPGGGGQGGGQQGAGGRMQGGFGGDAMGGRGGVPVGAGGMGGVRGGMRGGSLQTGAVGRWWDDKGYSNALGLRPEQRKRMDAIFNDSRGELAERYQALRTEETRLEAATRDSKVNQGSVFGQIDRVAQARDALEKTNTRLMGAIRKELDADQIARMQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K2</accession>
    <name>E8X5K2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3626</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3626"/>
    <dbReference type="EnsemblBacteria" id="ADW70629">
        <property type="protein sequence ID" value="ADW70629"/>
        <property type="gene ID" value="AciX9_3626"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3626"/>
    <dbReference type="HOGENOM" id="CLU_179110_1_0_0"/>
    <dbReference type="OMA" id="VADNTQP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="56" mass="5954" checksum="29CD2FB018AE199E" modified="2011-04-05" version="1">MGFFEEVAGAVVAVEGLKKVDPDASIITEGIAAVVGFEGTKEVTEHFEKKEEENNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T5</accession>
    <name>E8X5T5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna B domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4023</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572731.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70819">
        <property type="protein sequence ID" value="ADW70819"/>
        <property type="gene ID" value="AciX9_4023"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4023"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="THEGFAS"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234423" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1129" mass="122661" checksum="A238D5D96B36C15B" modified="2011-04-05" version="1">MRNPFVKTASLYLLSASLLATPSLLAQSNTGTILGTVQDDSGAVVPDATVTIKSLGTGETRTVKSSANGEYTFPNLQIGHYSVTVTHEGFASVQIADTELQVAQKATINPVIHVGAVTDKVTVIAAEVPLLNAATSSVGQVIDTQTVQNVPLNGRNFWQLTQLTPGVSFIQGGQNIASGGTSIRASAVNVNVNGLSPSWTGWYLDGANITEFQLGGTIIQPNVDALQEFKVESGNMGADYGHSPTVINATLKSGTNKFHGVLYEFLRNNALDAKNYFFVPPTGSTQRDEPLHRNQFGFAVGGPIYRDKTFFFVDLQETLFSQAQNFNSVVPTAAQRNGDFSALPVILIDPTTKLQFQDGGVLNKIPQNRISPQAQYLLKYMPLPNFVSNGTSRAIVTNKLKQQLGQGDIRIDHQLFAADHLTGRYSISDNRETDPNAYTALGGFPLRSRGQNAVVRETHVFSPKLINDLQVSYYRSYFLFTSSLQGTNIDDLAGITGLDGLAPPSTVGFPSVTISNYSNYNGQANNSYPKQNKIRSWQYVDHLNYASGKQDIRIGYELFHNTNTFIAGNNSTGTFNFNGLYTGKNCTATAGVTCGDNFADFLIGDPLSGSRSTFRNIWGSNGNFQSMFFQDDIKVLPNLTVNAGIREEINPFWTALKGQTSGFDTATGKLVIPTNIDPSVQPLTPSLLTLFADRFETTASLHLPENVRSTAYANVAPRLGFAYSPKPSTVLRGAYGIFFLFPDDNAINNTQNTVPFIASQTVNNATPTPTLTFGNFFSGQPVVTANTTNAVCSFGFVANSCSTPSITSMALHVQNTYIQEYNAAVQHQFGARISLDVAYVGNKTTHMQQAFQINDPNPAAGAVQNRRQLPQWGTISDSRFAGNGSYNALQTKFEARGFAGATFLASYTYSKCLTDGTYTSVVREDTPLIRYYGVCNYDLTHNFVTSYVYELPFGRGKTFLSHTNSIINQAIANWQVSGIVTLQSGLPYTPTISADQANTGVGSQRPNVIGRVTNTRNVNCWFFDSRNTACKSLAPNATDAYALPTQYTYGNGGINLLRSDGLVQFDMSLLKDFHFSESRSLELRGSFFNLFNHATFATPVTNIDSTTAGQVSSTLNGSRQIELAAKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X623</accession>
    <name>E8X623_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar basal-body rod protein FlgF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4127</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572819.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70907">
        <property type="protein sequence ID" value="ADW70907"/>
        <property type="gene ID" value="AciX9_4127"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4127"/>
    <dbReference type="HOGENOM" id="CLU_013687_0_0_0"/>
    <dbReference type="OMA" id="MQSGLYV"/>
    <dbReference type="OrthoDB" id="947161at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012836">
        <property type="entry name" value="FlgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02490">
        <property type="entry name" value="flgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="172"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="25298" checksum="DD826E1BBC59A7B3" modified="2011-04-05" version="1">MDSGLYAACTALMARTDALDTIANNLANSSTGGFRARHTTFSSVLAGSGRPLASQLNEATNSYGLLGGSHLDMQQGSLARTGSDLDVGIDGPGFLTVKTASGNAYTRNGSLQVSTQGQLITATGEPVLGENGPITIPRNSSVTISADGTISANGAIAGKLKLVEFSATADPQSMGSSYYTVPDKDVVAASKSEVRQGMLEGSNVNPVASVIELINAQRAAEGMRHAMTMIDTEIDKTAAQDLPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X627</accession>
    <name>E8X627_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma 28 subunit, FliA/WhiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4131</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572823.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70911">
        <property type="protein sequence ID" value="ADW70911"/>
        <property type="gene ID" value="AciX9_4131"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4131"/>
    <dbReference type="HOGENOM" id="CLU_014793_8_1_0"/>
    <dbReference type="OMA" id="FIRDKTW"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="278" mass="30806" checksum="FFC51E4EA72DC6A6" modified="2011-04-05" version="1">MASAHTIYKMIAEEEGGFEERNELILQELPQVHYIASRMMERLPQHVELGDLVHAGVIGLLEAYRTFDNTKNAQFKTFAKFRIKGAILDSLRALDWGSRGIRRKAREIAEATLKLEGALGRSPSKEEISAELGLTIADLNEIQTQLNGLHLVGQEVTSSFEGETAHDLIESAPSSWDNPFEMYAKAESKAHLIRAISELSEREQLILSLYYREELTMKEVAEVVGLAVSRVSQIHSAVLAKLKAALGHLAPEDVSKPKGVGPRAVLKSAETVQLQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X698</accession>
    <name>E8X698_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4203</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70982">
        <property type="protein sequence ID" value="ADW70982"/>
        <property type="gene ID" value="AciX9_4203"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4203"/>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_0"/>
    <dbReference type="OMA" id="MGHTFPG"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230273" evidence="1">
        <location>
            <begin position="28"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="292"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="784" mass="85453" checksum="C59556F65B486F45" modified="2011-04-05" version="1">MNVCARLVRIVCGMALVVVPAGLFAQASGYEAVNPFIGTGADGHTYPGATVPFGMVQLSPDTQINSFKHSYKWAAGYRYEDGTILGFSHTHFSGAGHSDLGDFLVQPISGEVRLEPGDANQPGSGYRSGFSHATEVAKPGYYAVTLADYGVRAELTATARVGVHRYTFPAGKPAHVLMDMRSSIYSYPGKVLWSRLRVRNDGTVTGMRETRGWAPGRQLYFAMKFSVPMATHEIYDKEPLPVEYRGFKTPGNNAADTQAMEGRGLIGVFDFGEMKGPLVVKVALSPTSEDEAMANLNAEVAGFDFDAVHAQAKATWEKALGAVQLTAAPDMRTNLYTALYHALLAPGTAMDVDGSYRGPDNQVHHADGFHFVSSLSLWDTYRAEQPLMTLLEPEARTTDLVRSLMASQQESPFGMLPVWQFQGIETWCMIGYHAVPEIADAVMKGIGGFDANKALDAMVATADYAPYGHLGEYMKLGYVPIDISNAGTDGSSHDESVSQTIEYAYDDWTIARVARKLGRNDVAVRFEKRAGNWKNVFDTADGFSEPRKADGSWRVPFNPAKAGAGSGFTEGNSWQYSWYQPQDEAGLIKLLGGDEKLVAKLDAMFNAKVDPKDYADVEDMAGLIGQYVHGNEPSHHLAYLYAYAGQPWRVQERLKQIVESQYKPAPDGLVGNDDLGQMSAWLLFTGLGFYPVAPGTNEYVIGRPFVERAVLKLPNGRSFTVVADGMSAEHPYVGSVTLDGKALTRSFVTHEEIMRGGELRFVMSGTANKSWGSGSGARPYSMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A5</accession>
    <name>E8X6A5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4211</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70989">
        <property type="protein sequence ID" value="ADW70989"/>
        <property type="gene ID" value="AciX9_4211"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4211"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_0"/>
    <dbReference type="OMA" id="PQCIPMN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="449" mass="48027" checksum="388289EDFBE07012" modified="2011-04-05" version="1">MDATRMKAMVLLGKSAMTGALGGLLFGFDTAVIAGATHALTVQYGLTPWQLGLTVSIALWGTVAGSLGSGVLGQRIGSRAALRIMGVLYVISALGCAFAPSWWFFLVCRFIGGIGIGGSSVLGPVYIAELAPAKWRGRLVGLFQINIVIGILLAYLSNAIIAHFSLGMLEWRVDLGVAVLPAILFLILLLSVPQSSRWLVSQNRIDEAMLILQSMGSPDSKAEVDAIQAGLRDEVGEAQSSLFNKRHSLPIFLAITIGMFNQLSGINAILYYLNDIFASADFGQVSANIQAVAIGFANLLATMLGISLIDRLGRKTLLMIGAVGCALCLAGVGVVFAMNAHQGLLLPLLIGFIIFFAVSQGAVIWVYISEVFPTNVRSKGQSLGSSAHWIMNGIITLAFPVVARYSKAMPFAFFAAMMVVQFVVVLMIYPETKGYSLEMLQEQMHKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I2</accession>
    <name>E8X6I2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4298</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpxP/Spy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572976.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71066">
        <property type="protein sequence ID" value="ADW71066"/>
        <property type="gene ID" value="AciX9_4298"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4298"/>
    <dbReference type="HOGENOM" id="CLU_1666938_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012899">
        <property type="entry name" value="LTXXQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07813">
        <property type="entry name" value="LTXXQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234446" evidence="5">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="17604" checksum="AAED22DC5E71EA9E" modified="2011-04-05" version="1">MKNLRLTLITAASLAVLATSAFAFSQSESSRGSQPRMIRRVIARFESRLNITTAQREQVKAILKTEEPTILALAAQAKQEREAMTALPTYNEAQVREVAQQYAATNTNILVERTKVRLELRAVLTPQQLQQLEQFKSTFGAGSGDRVGDRLDMVLNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J6</accession>
    <name>E8X6J6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582167.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71146">
        <property type="protein sequence ID" value="ADW71146"/>
        <property type="gene ID" value="AciX9_3863"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3863"/>
    <dbReference type="HOGENOM" id="CLU_072074_0_0_0"/>
    <dbReference type="OMA" id="HELAIMN"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="35003" checksum="C42D73BE3916D977" modified="2011-04-05" version="1">MSSNVSPSISRPFSVLAIVVVYRQHPGESTSLLTLEETIRRAGTTSPRISILVADNTPGGQQPGSLSPGIEYRPYPKNPGLAVPYNDALATARREGFDWLLTLDQDTQLPPDFLDSMVACAARCAHDPRVAAVVPRIVDGGLPISPFRFVGGFLPTVLTGKVAGLAPLHTSALNSASLLRVASLEAIGGYDPHFPLHNSDTRLYQRLDKAGYRVAVADGVIVPHEFSILRREQRMSPDRYRSMLADERDFWDRHMGPLGRLERIVRLAGRAVKGRLHKENAVFQRITVEELRYRLLYSRRARTRTRDGESSTRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R9</accession>
    <name>E8X6R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3943</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71219">
        <property type="protein sequence ID" value="ADW71219"/>
        <property type="gene ID" value="AciX9_3943"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3943"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="28768" checksum="51B1D9BD3899EE8D" modified="2011-04-05" version="1">MEQSHNMSDRLKTTDAKHKIQQTIFPIAPSPQFRLVAEGPGKVTMLYPKGSRIFSQGDLASHVYFIRDGSVKLSAFTAEGKEATLALLHTNDFLGEECISGENKLRSTSAIAGRNSLLVRIKKSNMVQSLRDHPDFMMEFFLYLLEKTSGMQENLTNLLCHRSEQRLARTLILLAEATDSAASETLLPEISQEDLAAMVGCTRSRANRLLNQFRKKGLIDYGHRITINKKLLQSVLKSVPSRAVNSHALIAGGKLIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S7</accession>
    <name>E8X6S7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6x reductase</fullName>
            <ecNumber evidence="4">1.3.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3951</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.54" evidence="4"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582245.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71227">
        <property type="protein sequence ID" value="ADW71227"/>
        <property type="gene ID" value="AciX9_3951"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3951"/>
    <dbReference type="HOGENOM" id="CLU_068627_1_0_0"/>
    <dbReference type="OMA" id="THPYAAQ"/>
    <dbReference type="OrthoDB" id="1726104at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27940" checksum="75049E30A1CCB779" modified="2011-04-05" version="1">MNSVSNTRRPAVLLLGGTSEAGAIASHLATHPDLKLISSLAGRVAHPKLPTGQTRIGGFGGVEGLITYLQQEKIQIVIDATHPFAANISRNAAAACQRLGIPLISYVRPPWTPQQGDHWQDVPDLEAAAALTRSYHRIFLAIGRQELAPFATCIHPWFLIRTIDQPDVPLPPNAKLILARGPFHLADELRLLKAHAIDCIISKNSGGPATYDKLEAARILGLPVIMVDRPTPPTNNVHTIEAVLSQISTELGRLITKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U3</accession>
    <name>E8X6U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3969</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582261.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71243">
        <property type="protein sequence ID" value="ADW71243"/>
        <property type="gene ID" value="AciX9_3969"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3969"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="WQGYYNA"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30883" checksum="F804BC10B4F138DA" modified="2011-04-05" version="1">MSAKQSVVLTGASTGIGWATAKVLLDKGFRVFGTVRKQSDADRLSAEFGKDFVPLLADVTDEAAVQQAATLVGEMLGKERLAGLVNNAGIVVGGPLLHLDPSEMRRQMEVNLIGPFLVTKAFAPLLGSDPARSGKPGRIVQISSVSGKMGVPFVGAYSASKFALEGMSESLRRELLLYGIDVIIVGPGAVITPIWDKAQAEDFSRFDATDYGPIIQRFLAFFAEEGKKGLAAEEIGHAIHRALTVSKPKVRYAVVPQRFKNWTLPNLLSKRMVDRILGKQFGLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U5</accession>
    <name>E8X6U5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3971</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582263.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71245">
        <property type="protein sequence ID" value="ADW71245"/>
        <property type="gene ID" value="AciX9_3971"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3971"/>
    <dbReference type="HOGENOM" id="CLU_1649740_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="178" mass="19688" checksum="CDADCE01E70F3FED" modified="2011-04-05" version="1">MRHSDPPAVVFAVLIPVLVVFLVFSIIWGLTSLWAWGRRRRLAAFAAAHGLSFQTGPAPITVPQVAHDPPRRLRVQENFLYGSRKGVEVFACDFRSGEGRGSTTMSMVAVRGDLRDTSLLDPKRWQLLPLNGWSFLIPNRDAGPSSRRKIGAAWDLLTAAVVHSDSPENEERETSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U8</accession>
    <name>E8X6U8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3974</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582266.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71248">
        <property type="protein sequence ID" value="ADW71248"/>
        <property type="gene ID" value="AciX9_3974"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3974"/>
    <dbReference type="HOGENOM" id="CLU_2450464_0_0_0"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9652" checksum="6E0B92B2DA3142F4" modified="2011-04-05" version="1">MKELTGAVSEIEGVLRQFVLSCRLNVEFRIATYPGCVPEVSIEFAGPDSWQLTSGDGELLQAVRQLTAEIRASDRPELLSCGVAEGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X704</accession>
    <name>E8X704_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3827</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71113">
        <property type="protein sequence ID" value="ADW71113"/>
        <property type="gene ID" value="AciX9_3827"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3827"/>
    <dbReference type="HOGENOM" id="CLU_266178_0_0_0"/>
    <dbReference type="OMA" id="FARYSAG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230832" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="869"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1123" mass="113607" checksum="EC113AD36852B766" modified="2011-04-05" version="1">MFKTISRHGLAALFATLLLAGNLTAQQTTSATPFSGRPAPWTRLATETPSTQALVDRTSATAYPMAPQPKAVNGYTFPGFVAPLRTGIGNGDGSETFGGVLSADIDGKNGIDVVTIQGDGILTVDLNDGKGNLSQASLNTSGSGANIVQAFVQDLNGDGLPDIVATSNTLPGYFVWMNQGNGVFGTVTKVAITAPTGITVRPIMGAMTVGDVNGDGKADLVLPISYISGSGSVGYTTTMVLYSYTGNGDGTFAAVPKSTLYTIPGYYIFQGGRSIALSDLSHHGALDAVLEMYQPPPGVTNYFFDIATVKGNGDGTFGPLVFAAKSIASTQYGRGSLLVRDFNNDGNPDVLFADAYTTVDICYGVGDGTLQPAVSAIANVGVSSLTAGDFNKDGVLDIITFRGGAAQVYLGTGSGSFKQTPTAQYAGSQGGNQVESAVDFDSDGNLDFFWVDPFYNSINIFLGKGDGTFRGAPAIAPANTTATLPNNTQSAFGFQVLAVGDYNGDGSTDIFAEESGYVDIGLSDRKGGFVFTRSLDSQNLTSVDFVEPLHVDLNGDGKDDIVMATLTGVRVFLSKGDGTLSTPVNTTIPISLGCTLNLASAGDLNGDGFADLVIAYGGNASCYATGTTPSGFAVLLGNGKGGFTSSLFTAFGGDLYQASLADINKDGKLDLVLNDLASGKNVITVIPGNGDGTFNTTAAHVVWTGIYRVSDVQIADTNGDGSLDLMMAYAGQSIASTTAPSGVLNLLGNGDFTFKSPVYALQGVAGQTAVLSDVNGDGLPDYIIPLSTQTTLISGVTVLINAGGGAFNAPILYTQPLDVLFDRDKLIFAGDFNGDGAQDIILGGGAGLVPSMLFLNNAGLSLTLGATSTSVVQGTPVNLFVEPNLLSTGNLSGTVTFASNGASIGTASWNSNVALLSTSSLPLGANKITATFPGDGTHAAASAAPITVTITAPPAAFSLTGAVQSVSVTQGSSASVALTLQANAGFAGPVTFACTNLPAGATCTFDSQTLTLAAGASAATKVTIATTGSASLQTLGPLSIGTGVSLAGLFALLLPTGRSRKKLYSLMMLLVTLAGAASLSGCGGSGNSGTPTGTALVTITATGVSGTTQVVNSILVAVTVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X705</accession>
    <name>E8X705_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3828</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71114">
        <property type="protein sequence ID" value="ADW71114"/>
        <property type="gene ID" value="AciX9_3828"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3828"/>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="ETAYDAR"/>
    <dbReference type="OrthoDB" id="1281138at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234471" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="6">
        <location>
            <begin position="257"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1195" mass="121343" checksum="7024179BC46B2E84" modified="2011-04-05" version="1">MALLSGFYTRLVQAALLLTTATLGVAQSQRTAAKPLPQITHAVDESQRARISGGLTAQTATATDQGALADGAPLDGIILMLKRTDAQEQVLQALMAAQQTPASPEYHHWLTPDEFGARFGVADQDLATVSSWLGSKGFKVDSVARSRMSISFSGTAGQLKSAFSTEMHQYLTTDGTRHHAANSELSMPEALTPVVQGIASLSDFRLKAMHKTLGVVSRNRATGASRLVAQSTAVRDQAEGNQASVPQLTNAGSPAYVIAPADFATMHNVTPLWNAGIDGTGQTIAIVAKSDVLNSDVDSFRSSFGLPATKLNHIYVGGQNPGLASSEVEAVLDVEWSGAVAKNATIDLVVASDSATTDGIILSAQYIVDNNVAPILSMSWGECELGMGASEAQYVNTLWQQAAAQGVSVIVATGDAGSDVCDQGSTYGVYGLSVNGFASTPYNVALGGTDLNVSYTNPAPYWNTTNASGTMQSAKSYIPEVPWNDGCGNPLILAALQAEGVTDATTAALCNDSKYYTGFHKVEGGSGGASNCTVSTYVSSSNFTCTSGVAKPSWQTAVPGIPTDGVRDLPDVSLFAGSGLWGSAYAICESDQSPDGTCDFTNPADVAYLAAGGTSFGTPAFAGIMALVNQKQSSFQGNPNPVLYQLAARQYNNSTTSGSCTAENAATGNSCYFYDTTKANNAAPCYKGSKDCVTIGANSYGIQSGWNAGTGYDLATGLGSLNVSNLVNNWSAVTTGTLATTSVVKLSQATIGYGSPISGTITVASTSGTPTGDSSVLTDSYANGPYTLASGTASFSAPGLPAGTHAFTARYAGDGTYLPSTSAAVSVVVSKAASTLSMALTRTSVTSGDFITVSSTIGTAVTSSSPTGLVTFTNSTTGATLGTATAQSSYDTAGHTTAIAGFTFNSNQLVSGKNIIMATYAGDGNYTSSSASSVTVTYVAAFNLTAAQTQLAVPTNSSASIALTLTPSGTALTSAVQFSCPTTLPAFLSCSFSPAVLPVGTKTTTTTLTLYAAPMAQASVTAPPVPGSAIAGIALAGLFFGLSFGLRKLSRGLVFLVAFTICLGLLSLSGCAGKGSPATSSVALTASAPTVAYGQSETFTASISNAPTATGQISFVDGGKQLGTQSLSGGTTTLTTTRLAVGVHSVTAVYSGDSNFATATSTAASAAVTYSLTVPVLATDNNGNAVTLNIPVVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7A3</accession>
    <name>E8X7A3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4386</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573056.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71337">
        <property type="protein sequence ID" value="ADW71337"/>
        <property type="gene ID" value="AciX9_4386"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4386"/>
    <dbReference type="HOGENOM" id="CLU_099442_0_0_0"/>
    <dbReference type="OMA" id="YLCMSAS"/>
    <dbReference type="OrthoDB" id="1570961at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="172" mass="18876" checksum="A6EB07BD74494A82" modified="2011-04-05" version="1">MLRPFDIAVLLKLTLPGAAESSFQKLASDLHVASSEVHGAVKRARLSGLLQHDDGPKKVNRSALLEFLGHGVRYVYPAVRGEMTRGVATSFAAEPLRSVIHDGGTEVPVWPYVLGKVRGYSFEPLYKHAAEAALSDPAFYELLSLVDALRDGRIRERKIALEMLSKRLLVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T0</accession>
    <name>E8X7T0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_4584</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573233.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4584"/>
    <dbReference type="EnsemblBacteria" id="ADW71514">
        <property type="protein sequence ID" value="ADW71514"/>
        <property type="gene ID" value="AciX9_4584"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4584"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564709_0_0_0"/>
    <dbReference type="OMA" id="ENYLHEF"/>
    <dbReference type="OrthoDB" id="1452766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="9">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="483" mass="53982" checksum="ED2DB823D55862E1" modified="2011-04-05" version="1">MLEALIRQRYVFLSVFFTVLALGAVYIFGSHKKYASRMELLVQNARSEQVITAGRSEAPATAAEVSEEEINSEIELLQSADVLDEVIDPGWSKTSPSQRPLDEQQRHEGAVGSLQDNLAVTPIRKSHVISVQLVSRDPHQSTLVLKKLLDVFLQKKLQINHPAGASQLFDQEAERYRLQWQRAEQALSSFQQQNGIVSITEQEGGLQKQLFDADTQLRDANVEISELTHKVTADNDQLQALPSRRPTHETAIPASGSIDQLRTRLSELNLSRTELVSKYKPGDRLILQVDEQIAQVEATLKNMNGSYYAETSTDINPTWQAVEQDLSSTRTRLEGVSGRRHELADQITRLNSRLGNTEEQTQELNALQRRVAETEANYQVYAQKRDESHMTDVLDEHQLLNVAVAQAPTFSLSPVRPRPKKDGLLTFLTAVFLGGFGVFLVENSRSTIADDSELEAVARYPLLASVPVRSRLDANSHVDDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U2</accession>
    <name>E8X7U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4596</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573245.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71526">
        <property type="protein sequence ID" value="ADW71526"/>
        <property type="gene ID" value="AciX9_4596"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4596"/>
    <dbReference type="HOGENOM" id="CLU_1466258_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234489" evidence="1">
        <location>
            <begin position="35"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="19589" checksum="14F29EC44D493D8B" modified="2011-04-05" version="1">MPTQGTKSRVAGTIARRAGAFVIAFTAASACALAQSPDPNQLPTAPALGRYTDTLSKICGSNRVDVNPSKIPFIGCFALKAGTSLSGDVDGRAVTIRVPLQGEEIIEVDDNAVRRTSSSTTNVEGVKPGASGFSICTKDKPKDCPVLSALMRKPGSFVSFDISRAFKPRSYVTNQENWDYESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U4</accession>
    <name>E8X7U4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4598</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71528">
        <property type="protein sequence ID" value="ADW71528"/>
        <property type="gene ID" value="AciX9_4598"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4598"/>
    <dbReference type="HOGENOM" id="CLU_1254463_0_0_0"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="25351" checksum="BC327BC91DACB6C8" modified="2011-04-05" version="1">MMPYAFCMTDGFLVPQQQRSRETLARLITATLVTLEKHGLEGATISRIASEAKIAPASVYRRFRDRNALYRVALLSMLEGAASLEHINEVFGDQTLEAHVHRMVSFTLQQYRLRPGLMRALIRFIGSDSDEEFRARALRSISINFERFADRLLAYREQIKSSNPHKAVIFALLTMGTVIEVRALEQVSMWNELTRFDDEEFVIEVTRNFLGYLGYSDQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z1</accession>
    <name>E8X7Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71575">
        <property type="protein sequence ID" value="ADW71575"/>
        <property type="gene ID" value="AciX9_4645"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4645"/>
    <dbReference type="HOGENOM" id="CLU_2770116_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="8057" checksum="47FF8946088CFA41" modified="2011-04-05" version="1">MRVAATDIPTDFRIRGLNSALADILKAMPTQRLVLLLLAGLCFMWLCVRIGKYLWRELNEYLRDQRFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X815</accession>
    <name>E8X815_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4669</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71599">
        <property type="protein sequence ID" value="ADW71599"/>
        <property type="gene ID" value="AciX9_4669"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4669"/>
    <dbReference type="HOGENOM" id="CLU_2142378_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="12590" checksum="1C92BABA05900BEF" modified="2011-04-05" version="1">MLFVTIESEITMVALMTLFLAASFFGNKPSRNAVTEQSIVSDKSVQAKQPDIVDLPIVPSGASRVWLDTARNHYRCSYERQYGKSKTGEYLTEKEARDKGARPFNKRGCPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X826</accession>
    <name>E8X826_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4681</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71610">
        <property type="protein sequence ID" value="ADW71610"/>
        <property type="gene ID" value="AciX9_4681"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4681"/>
    <dbReference type="HOGENOM" id="CLU_2825090_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7458" checksum="FB634A0747E3816D" modified="2011-04-05" version="1">MIDSVPPLCPIGLKLIEDFANRYPMAGPYIAHMVQTGVPIPMYADNRVWEKLSDHRKTCAICNQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV60</accession>
    <name>E8WV60_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0161</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0161"/>
    <dbReference type="EnsemblBacteria" id="ADW67235">
        <property type="protein sequence ID" value="ADW67235"/>
        <property type="gene ID" value="AciX9_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0161"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040286_1_0_0"/>
    <dbReference type="OMA" id="FERWDGR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="278"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="300"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="469" mass="51612" checksum="D707DDD8DABB0BFC" modified="2011-04-05" version="1">MIATAERAAAKSSRSQSSSNPEQVTFSSIIAALSFALDLTEGAQPGHALRTCLIGIRIGTEMGLSQDQLSDLYYALLLKDAGCSSNATRLYQIVGGDEIRAKAFTKTNDWTRFEWKQIQFLLRHVHAQDKIANRFKAIGDMIKKSSQNAEILFRLRCNQGAQVVRDLGLGQGTADAVYNLDEHWNGLGYPDRLSGDAIPLLARIVSISQTLEVFHQQYGPAAALDCIQRRSGRWFDPLVVRAAVSLMRRNALFVDIDSPVLKHYVASLEPSLRSLPADPQTIDSICVAFAGVVDAKSHSTYMHSTEVARIAVELGAYLGLNDSELVTLRRAGLLHDIGKLSVPNSILDKPGKLDASEWACVKMHPHYTYEILSRIPTFGEIANISASHHEKLDGSGYYRGLMADDLCYMSRILTVADMFEALSANRPYRGPMSKADVLNILRKDVPHAIDPTVFAALESIIEINNLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV88</accession>
    <name>E8WV88_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0189</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578591.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0189"/>
    <dbReference type="EnsemblBacteria" id="ADW67263">
        <property type="protein sequence ID" value="ADW67263"/>
        <property type="gene ID" value="AciX9_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0189"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_0"/>
    <dbReference type="OMA" id="PLRMWTY"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="35340" checksum="6A88203071840952" modified="2011-04-05" version="1">MKLVSIVSPCYNEEENVDILIERVRTLFAGMPQYRYEHILIDNNSSDRTVDILRGIALDDPHVKVIVNARNFGHIRSPQHAILEAQGDAVVVLLSDLQDPPELIGEFLREWEAGYPIVVATKSTSDESGLMYGIRSVYYRTIARLTDVKVVEHFTGFGLYDRQVIEILKRDFPDPHPYFRGQIAEIGLPTKVLHYNQKRRMRGITKNNFYTLYDMAMLGITNLSKVPLRLVIFTGFVFAFLSLIAGLVYLVYKLVYWNRFELGLAPLMIGLFFLGSIQLVALGIIGEYIGSVHTIVQGRPLVTEKERINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH1</accession>
    <name>E8WVH1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579742.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1359"/>
    <dbReference type="EnsemblBacteria" id="ADW68419">
        <property type="protein sequence ID" value="ADW68419"/>
        <property type="gene ID" value="AciX9_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1359"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_9_3_0"/>
    <dbReference type="OMA" id="DCREAKR"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9524" checksum="B187BA7F6658E186" modified="2011-04-05" version="1">MDLTVYSASWCRDCREAKRFLAKHNIPFKEVDIEATPGAADEVLANVGKKAIPQFVLDGKWIQPYRPGQGFLHAEMATLFGVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL6</accession>
    <name>E8WVL6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2513</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69545">
        <property type="protein sequence ID" value="ADW69545"/>
        <property type="gene ID" value="AciX9_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2513"/>
    <dbReference type="HOGENOM" id="CLU_3043935_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="5985" checksum="6284FFD17C3F18C0" modified="2011-04-05" version="1">MIGVNLPSIRRFRTICKIALAAVAGMHPIEQFIPFQKDCVVAHDLFDAAIIFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVP5</accession>
    <name>E8WVP5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2544</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580889.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69574">
        <property type="protein sequence ID" value="ADW69574"/>
        <property type="gene ID" value="AciX9_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2544"/>
    <dbReference type="HOGENOM" id="CLU_1432711_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20496" checksum="87D9455ADB25E2F9" modified="2011-04-05" version="1">MTLQVLNSFPYTFLPSGILIVEPHAGLLTARSMLLAAADHYVGVSACSGNQSERNEECEVAIAILSESLGRAVLSGTAEIVRRNWPRARILIFGSSGAAIEDHLYDARIDHRARSEELLAALLMLTEYPRNQKATPTAILADGRVERLLTGGAIGRIAESDPTKRLVGKVETAYSRNLPGAEQPFRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS8</accession>
    <name>E8WVS8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3686</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581996.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3686"/>
    <dbReference type="EnsemblBacteria" id="ADW70687">
        <property type="protein sequence ID" value="ADW70687"/>
        <property type="gene ID" value="AciX9_3686"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3686"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_2_0"/>
    <dbReference type="OMA" id="RMSKMTD"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="163" mass="17007" checksum="14AC2C2DCB497217" modified="2011-04-05" version="1">MLRLTKKADYGLMALKYLAEQAAATSGNAAHNYAQSAKDIAEAYHIPPQLLAKILQTLAKGGLLVSHAGTNGGYALARSAAEISAFEVIRAIDGPLFITSCITIHGTCDLDSHCTIKEPLRKVNDSIKDLLSAIRIADLIDPADASQPRAAAALGGGLVSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV9</accession>
    <name>E8WVV9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Asparaginase</fullName>
            <ecNumber evidence="6">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3717</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + L-asparagine = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582027.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3717"/>
    <dbReference type="EnsemblBacteria" id="ADW70718">
        <property type="protein sequence ID" value="ADW70718"/>
        <property type="gene ID" value="AciX9_3717"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3717"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_0"/>
    <dbReference type="OMA" id="RRMAWGY"/>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04702">
        <property type="entry name" value="ASRGL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033844">
        <property type="entry name" value="ASRGL1_meta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="5">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="32882" checksum="773E56EA5E87D46F" modified="2011-04-05" version="1">MPEKLPILLIHGGAWAMPDAEIDAHENGIRNALAAGYALLERGASAVDAVEAAVVVMEDDETFDAGRGSFLTRDGRVQLDALLMNGADLRTGGVACVERLRNPIRAARLVLEESPHVYFVGTGAERFAMQHGMSLCDNMDLVIPREQKRLYAAQEAELAGLKDTTFSGGSPEATIPDPLLSHDTVGAVALDIHGNLAAATSTGGTLNKAPGRVGDSSLIGCGCYADNLSAAVSLTGWGEPIMKLVLGKWAVDRVQAGATPQQAATDAIAYLHTRLGGHGGVILLGPDGSLGIAHNTPRMAWGLATPAGHSLGVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW27</accession>
    <name>E8WW27_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0259</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578661.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0259"/>
    <dbReference type="EnsemblBacteria" id="ADW67333">
        <property type="protein sequence ID" value="ADW67333"/>
        <property type="gene ID" value="AciX9_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0259"/>
    <dbReference type="eggNOG" id="COG1953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_0_1_0"/>
    <dbReference type="OMA" id="MLVLLKF"/>
    <dbReference type="OrthoDB" id="326558at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="484" mass="51828" checksum="17478B7141D2BF7E" modified="2011-04-05" version="1">MIAAPTTRGSTEISDPDPRLYNADLAPTSVEDRTWGTYNYIALWFSMSMEVTTYMLAAGLIAGGMNWWQAVLTILLGNLIVLIPMLLNAHAGAKYGIPFPVIVRAPFGPRGANVPALLRAIVACGWFGIQCWIGGGAIAAMVGVLAPSTAGSQPILWACFLGFWLLNMIVVYRGVESIRHLQSFSAPFMAIMSLALLAFLYHRAGGLGPMLAAPSQFHTTRSFLAFFLPALTGMVGYWATLSLNIPDFTRYAKSQDAQIFGQAFGLPVAMTLYASLGIACTSASAVVFGHPIWSPVELLGKFHQPVVAFFALIGLLVATLNVNIGANVVGPSNDFANLAPSRISFRTGGLITGVLGLAIMPWKLMSSSSNFTSWLVGYSGLLGPVAGIMVADYFLLRHRRLSLDDLYRRNGAYEYSSGINPRALIALVAGVALALVGLVVPALHWLYSGAWFVGFFVSAGVYLALMTSVGATSTLQQSLELERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW60</accession>
    <name>E8WW60_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ordered locus">AciX9_0294</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578694.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0294"/>
    <dbReference type="EnsemblBacteria" id="ADW67366">
        <property type="protein sequence ID" value="ADW67366"/>
        <property type="gene ID" value="AciX9_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0294"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_0"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="269"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="593" mass="65864" checksum="A2190C80F643C744" modified="2011-04-05" version="1">MADNFAQTVKTQVDIVKIIGEYVKLRKTGAQNYSGLCPFHKEKTGSFSVNAAHNYFYCFGCHEKGDVFTFVMKLDGLSFPEAVRAVAAKAGIPLPKREFSSPEDAQEAGIRKKLVDLHEGATQYFEAMLKSPGAAGAREYLSSRGVTAETIAKFRMGFAPDDFNDMREKMKPHFGDDVLRASGLFNSSEKDDDGHPTGQLYARFRKRIMFPIANEQGKTIAFTARALEAVDDKGRPIAKYMNSPETPLYTKGNVLFNLDKAKADMRAHDFALLVEGQMDCISVYMAGIKNVIATSGTAFTEMQVRLLSRFTKRVVVNFDPDQAGATAAEKSIALLTEEGFEVKVISLEGGLDPDRFVRENGIQAYMGALRTAKRQSEYLIDRAMQQFPARTADAKVQAMNFLLPHIRRMPSRIHRDEFAADAAQKLGIDSALMRQELKQAAAQKLESVKAHRAEPANETERVLLQALVRPETDAARVRAANGLADHPEWYEGMGAAALFDTLAHGVAPENPIDAAQDDASRSMLAEVLSSGPGERSLVELVEDAFHTLAFRHLERRQRELRMSMAEAQRRGDEAMVETLMMEKVKVDRALREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW75</accession>
    <name>E8WW75_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar protein FliS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1399</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1399"/>
    <dbReference type="EnsemblBacteria" id="ADW68458">
        <property type="protein sequence ID" value="ADW68458"/>
        <property type="gene ID" value="AciX9_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1399"/>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736565_0_0_0"/>
    <dbReference type="OMA" id="FYAAMFT"/>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="155" mass="17145" checksum="17E7D6263EFF1482" modified="2011-04-05" version="1">MEAMSYQQQSLVGATGVELIVALYDAAIRNLYRAADSAREEDVIGRRIAVKKAVDIFIYLQARLRPDVGGRAAASLSDFYAAMFTMTLEASHIGSVDGFMEVIDCVRNVREAWAIVARDPDAGKVLPRELRTREERFVAPVHAQQEQAAASRWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW91</accession>
    <name>E8WW91_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1416"/>
    <dbReference type="EnsemblBacteria" id="ADW68474">
        <property type="protein sequence ID" value="ADW68474"/>
        <property type="gene ID" value="AciX9_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1416"/>
    <dbReference type="eggNOG" id="ENOG5033B63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199613_1_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043727">
        <property type="entry name" value="DUF5670"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18919">
        <property type="entry name" value="DUF5670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="5299" checksum="8253660E9DC2D292" modified="2011-04-05" version="1">MFLILAVVLVVAWLGGFVMFKSAGLLIHLLLIFAVISIILHFVTGSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB1</accession>
    <name>E8WWB1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1439</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1439"/>
    <dbReference type="EnsemblBacteria" id="ADW68494">
        <property type="protein sequence ID" value="ADW68494"/>
        <property type="gene ID" value="AciX9_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1439"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_0"/>
    <dbReference type="OMA" id="CWEALLW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="89"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="317" mass="33455" checksum="BDE4F16A7BDA4F2D" modified="2011-04-05" version="1">MPTQIKNDATAPWFLEHSISAEDQTAMAAMRAIVTPNKGKLQGIQARVPFGGIMERVVAPEAIDYVADKIGGIPGWWCRPANAPSDQAIMHVHGGWFSWGSAESFRHLAGHIAARAGIAVFLPDYRLAPEHPFPAAFEDVKAAYVGLAESGYSKIAVTGDSAGGNLALALLVYLAQSGGTSGDALIGGVAISPVTDLSLSGESWSSRAEADPLFTKPQASGLVEAYLVGHKSEDPIASPLFADLEGLAPIRVHVGNDEVLLDDSVRLVERAVAAGVDARLDVWNGMIHGFLGSVGRLEASSQALQAIGQFLRHRFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM7</accession>
    <name>E8WWM7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3772</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582080.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3772"/>
    <dbReference type="EnsemblBacteria" id="ADW70772">
        <property type="protein sequence ID" value="ADW70772"/>
        <property type="gene ID" value="AciX9_3772"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3772"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_0"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="301" mass="33023" checksum="1DBA7A649510411E" modified="2011-04-05" version="1">MPPSPDPKRRALGKGLESLLPSLKAEAAPPSTGKPLEIPVGLIDRNPFQTRTTFDEAKLTELAQSIAASGVVQPIVVRVLPGDRYQLITGERRLIASKQAGKATIPAIVREVSDEQAMEMTIVENLQRADLNPMEQARAYHRLSHDFKMTQEQMATRTGKDRASVGNFLRLLKLPETIQARVEAGDLSFGHARTLLGLGSPEQIASAAQKVMALSMSVRQTETYIHGLMNPESRPGKLEKQQIAEAGQDPNVHEAQTRLQRSLGLRVKIEDKKGKGKVIIEYANLEDFDALLTALNAQPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWN5</accession>
    <name>E8WWN5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ordered locus">AciX9_3780</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582088.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70780">
        <property type="protein sequence ID" value="ADW70780"/>
        <property type="gene ID" value="AciX9_3780"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3780"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088964_0_1_0"/>
    <dbReference type="OMA" id="HASGWLR"/>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="21939" checksum="56E00993F6A60B29" modified="2011-04-05" version="1">MASLLSIESSPRGEYSISRKLTSAFVEEWQKTHAGGTVVNRDLFTTTLPFVDLPWIAGAYTPAEQHSPEMKKALEIGNTLIAELKAADHIVLGTSMYNFSTPAILKAYIDQIVRVNVTFTPQYEGLVKGKKLTIILASGGVYTPGSPTEGYNAESSYLKQVFGFIGITDVNIVLAGGTGAVSMGQRSLEDFVAEFTPAVLEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX23</accession>
    <name>E8WX23_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uncharacterized protein YtcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1531</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YtcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579903.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1531"/>
    <dbReference type="EnsemblBacteria" id="ADW68584">
        <property type="protein sequence ID" value="ADW68584"/>
        <property type="gene ID" value="AciX9_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1531"/>
    <dbReference type="eggNOG" id="ENOG5030Y81">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157779_1_0_0"/>
    <dbReference type="OMA" id="AFPGWFF"/>
    <dbReference type="OrthoDB" id="1889065at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031381">
        <property type="entry name" value="YtcA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17090">
        <property type="entry name" value="Ytca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9898" checksum="67C1409FF617265C" modified="2011-04-05" version="1">MKPIRHSQAAFTGLCLLLTGCGHAPNIDIIGSFFPVWMLCLAIAIALSFVVRVFLVRLKMESEVGPLALFYPCSVIFFTSLMWLIFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK7</accession>
    <name>E8WXK7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1570</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579942.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1570"/>
    <dbReference type="EnsemblBacteria" id="ADW68623">
        <property type="protein sequence ID" value="ADW68623"/>
        <property type="gene ID" value="AciX9_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1570"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_3_4_0"/>
    <dbReference type="OMA" id="GPPGYEI"/>
    <dbReference type="OrthoDB" id="1770011at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15347" checksum="5D7854AF6A7C7411" modified="2011-04-05" version="1">MTRQLNRLQPWGICLLRIVLGVAMTYHGYQHLIPPGGLHRSNPLGGFDYFNHFVVSLGLPYWLGYVSVCTEFLGGLCLVLGFLTRSAAFMVAGNMLVALIKVNLHHGYAGSEYTLALIAMALLLVLTGSGTLALDRRLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ2</accession>
    <name>E8WXQ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1615"/>
    <dbReference type="EnsemblBacteria" id="ADW68668">
        <property type="protein sequence ID" value="ADW68668"/>
        <property type="gene ID" value="AciX9_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1615"/>
    <dbReference type="eggNOG" id="ENOG502Z9TW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640558_0_0_0"/>
    <dbReference type="OMA" id="HDKANYF"/>
    <dbReference type="OrthoDB" id="816782at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="428" mass="44560" checksum="25BEA897205C1BBA" modified="2011-04-05" version="1">MLGGVAFAAPVTGVVTNRTTGKPSGGDDVVLLRLAQGMQELARAKTDSKGRFSIEVPNDGLHLLRVTHDKANYFKPIQPGTQSVEMDVYTAAAQVDGVTLDADVMRLQTDASGGGLKVVEHFFVKNESSPAKTLMSEHPFELYLPAGATVEGAAAKAPGGMAVQSPLVPEGEPNKYTMIFPIRPGESEFQVSYKIAYKDSFTFKPRPVMATDTIAIMMPKSMTFTAGKGTPYSAVTEELGAQTYVARNAQPSQPLDFTVSGIGELPRDTAAGAAGGPTAGGPGASDAGAAGPGGDPQTPGEASQQMRGDTKPGKGIGNPLDSDGNLEPWAKYKWWIIGGLALVFAAGAGIMLRTPTAPVVAGAGYVPAGPGGLLQVLRDEMFAVETDRLEGRLSEAQYGELKAALDVVLKRALARSGKAAETVQVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR9</accession>
    <name>E8WXR9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581079.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2740"/>
    <dbReference type="EnsemblBacteria" id="ADW69764">
        <property type="protein sequence ID" value="ADW69764"/>
        <property type="gene ID" value="AciX9_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2740"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121374_0_0_0"/>
    <dbReference type="OMA" id="FTWGHYD"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230434" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="20634" checksum="7D0B5FF01079362A" modified="2011-04-05" version="1">MLRSTMFRTSLRALFVIVAVGEGMAQQLPGTIPGQTVPSGNSGYRIISPLTLPVLTPGVVELMELEGRFQEAVAAGGGKVFSEWFADDAVVLNNGKPAILGRGAITAQAQWDPKSYQLTWNPQGAQMGPSNDMGFTWGHYDGKSINPDGHPTVTSGRYFTVWRKSKDGVWKVILDASANEPPGAGDCCSLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY11</accession>
    <name>E8WY11_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578878.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0478"/>
    <dbReference type="EnsemblBacteria" id="ADW67550">
        <property type="protein sequence ID" value="ADW67550"/>
        <property type="gene ID" value="AciX9_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0478"/>
    <dbReference type="eggNOG" id="ENOG5032RYR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116315_0_0_0"/>
    <dbReference type="OMA" id="AWTANEY"/>
    <dbReference type="OrthoDB" id="1972825at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="PTHR35519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18744" checksum="AA755850ADAECF79" modified="2011-04-05" version="1">MAITAKPEVLSPRTKRGGKAFDDEHLDLLSHLLDDFIRVPGTPIRFGLDGIVGFIPGVGDVLGGLASSIIIVAAWVRGVPRVTVARMVLNVAIETAVGSVPFLGNLFDIGWKANRRNYKLLRGSIDAPERHTGMSWLFIAGVCVVLAALMFVPLVLIGWGLHTIGMDLHKLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY14</accession>
    <name>E8WY14_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0481</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578881.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0481"/>
    <dbReference type="EnsemblBacteria" id="ADW67553">
        <property type="protein sequence ID" value="ADW67553"/>
        <property type="gene ID" value="AciX9_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0481"/>
    <dbReference type="eggNOG" id="ENOG5032RFX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324839_0_0_0"/>
    <dbReference type="OMA" id="SYIDLLW"/>
    <dbReference type="OrthoDB" id="1388301at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22895" checksum="66F8B67D87172E92" modified="2011-04-05" version="1">MDADWSAECGTDDPVLVVPWSGDSSDPTNPQPLQFIDLRENPYDLDQIQEAEHHPALLQALRALNAGRSPVFTAKCDAWPLSPEELEHLALTLATEPVESAHGFASYIDLIWRERSLFVSRHRHEQLLDSLIRSAEPLDLPHAVLECIVRPALVDLTGPQEGFAVTLYLKALGPDATSAYANWAEALESAVALIRNSDRTNPRSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY63</accession>
    <name>E8WY63_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1638</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580009.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1638"/>
    <dbReference type="EnsemblBacteria" id="ADW68690">
        <property type="protein sequence ID" value="ADW68690"/>
        <property type="gene ID" value="AciX9_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1638"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_0"/>
    <dbReference type="OMA" id="DPGIFWN"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="259" mass="27228" checksum="908F6379029FC2F1" modified="2011-04-05" version="1">MPFGSPESFLKDKVTAIQDYSLLAGRGVANLFSPPVYWDDIFTQMDSIGVGSLPIVVLTGFFTGCVLALQSATALKQFGSISLTGSLVALSMVKELGPVLTGLMVSGRNASGMASELGSMMVTEQIDAMRALGTDPIRKLVTPRIIATVVMLFFLTILSDAVGIAGGALVSVTILGLNLSSYLHTSYQSLLYGDVVQGLTKPLFSAFIIATVGCFFGLKTKGGTQGVGKATTQAVVYSSVFIIVVDFLVSRLMIGLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI0</accession>
    <name>E8WYI0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2863</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581201.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2863"/>
    <dbReference type="EnsemblBacteria" id="ADW69886">
        <property type="protein sequence ID" value="ADW69886"/>
        <property type="gene ID" value="AciX9_2863"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2863"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_4_0_0"/>
    <dbReference type="OMA" id="PYECCGL"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="16284" checksum="28040119F13F9DE5" modified="2011-04-05" version="1">MLKINFKEYEALRAHGQETYPHECCGVLLGKAADGANEVREVVRAGNTRTDSAHNRYNIAPGELIKIQRQARNAGLDIVGFYHSHPDHPAMWSATDIAEAHWIGCSYVITRVAGGNAEITNSFLLQGTGEDDKSFADEAIEILMAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ8</accession>
    <name>E8WYJ8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain fatty acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0524"/>
    <dbReference type="EnsemblBacteria" id="ADW67596">
        <property type="protein sequence ID" value="ADW67596"/>
        <property type="gene ID" value="AciX9_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0524"/>
    <dbReference type="eggNOG" id="COG2031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037744_0_0_0"/>
    <dbReference type="OMA" id="QDKTIAH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006160">
        <property type="entry name" value="SCFA_transpt_AtoE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41983">
        <property type="entry name" value="PTHR41983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02667">
        <property type="entry name" value="SCFA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="472" mass="50604" checksum="0D04497675F41AF4" modified="2011-04-05" version="1">MKTETMHQSVTPSIQEPTFTKQTLLGRCTAVSVYLFENLMPDPFVFAVLLTFVGAALAWWLAPNATPVSIVGAWYAGIFALFTFAFQMVIMLVAGYALATAPPVHRLLARIASLATTPASAISLTIVVGMLASWLNWGLGLVTAALIAREIAKRVKVDFGWLVAAAYSGFVISTEGLSGSIALSQATHGSALNIVEKVTGHGLPLSQTVFTTFNLVPIAVLLIVLPIVFRYLAPTPEATLYADPERLRAEDQQKPILEAPDTFGARLDHAWILNVLLALFGFFALAMEFKRTHGAVDLNSVIIVLLMLGLLLHWRPAAYVAAVKHAARISGPLVLQYPLYGGLMGIITTTGLAAVLSKIFIRYSTAHTLPFFTYLTSLVITLFVPSGGGHWAVQGPFAIPAAQNLHASLAGTTMAVAMGESVANMLQPFFALPILAIAGIRMRRMMGFMVVTFLISLVVFGASLLLLVPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ66</accession>
    <name>E8WZ66_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578996.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0597"/>
    <dbReference type="EnsemblBacteria" id="ADW67668">
        <property type="protein sequence ID" value="ADW67668"/>
        <property type="gene ID" value="AciX9_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0597"/>
    <dbReference type="eggNOG" id="ENOG502ZI40">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346739_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234186" evidence="1">
        <location>
            <begin position="34"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="814" mass="85306" checksum="47BD54BDDB00EA4F" modified="2011-04-05" version="1">MSKIPGFSAIRAVASPLAILVLAILQSPHPASGQNASTQPLPATNLREALRRCASPQGCSLQLPQESTLTGEDPAWLHLGDNIISRAFLYPPNTHLHDTRSGHDISFASNVGGQGQGFAFFTRFDRNLPSDGGGPPQANIAASYFAGAPGTYAYGSETVMHNILLNSIFSTKGIAQAIGSVARKYGTGDFGGQYAYDSCMGGAINGDDEGCNANYAALWEGFGDINAKNPHGTIPIAFIESIGSSGAGHSSLKLKLTDEHASNNALGAGRFAVLVRTPDGRDAALHTFTVTAHNDSTSADKFGSYTVAEPAPVSAVWGRSTAPIVVPNNNDVPQTITATIAIDPLSPEAATGYRKGIACMWGWRRNERVEIVEAGTPAAGSQALTLKIRQDPGGGDQPHQSPYFFQDAKSGGLCQTVGRISAYDEGAGLPTQNVPLMGAVLLHKGDTVSHTVVYNFNWVHGNFGTIGGLQEAMPITLKVKLKRVGNAAIIVQADQDATQLNLMPNVKIVDASDPTFDTSATSFHAYPDGLGYESKGPNTSPVTATVIANSGRNLLKVYSAAEIIAVADPDAESSTLGDFVALEPNSIPWPVHGTVDFPAHHSVFLQMSADWLHTVSPGMANGKVFIYDGPSINAGFSAIQLVNYNPASKYVGSGGLLRGPDAFLIGGPHQTIFDLGQYGVAPLLPNGNVTVVGCVLGDCSSSSASFNMEQVSLRSSHFIRQFDQYNNRASMGFQNGERLLFTAGQGLAINANLSMEGRVVKDLADPVQPTDAVNLKSMNSAITGAVKGYSGPLTLSPSCTVTVTNGLITGKTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ67</accession>
    <name>E8WZ67_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0598</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578997.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0598"/>
    <dbReference type="EnsemblBacteria" id="ADW67669">
        <property type="protein sequence ID" value="ADW67669"/>
        <property type="gene ID" value="AciX9_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0598"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632771_0_0_0"/>
    <dbReference type="OMA" id="CIREAPE"/>
    <dbReference type="OrthoDB" id="1169561at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="433" mass="46622" checksum="DC198D7C63647F20" modified="2011-04-05" version="1">MHLWSDYEGKTIAGAYPLGQLIRPEGRTAFFSTSNGTGIPAVIRLTESLNDEGEMLERWRQVTAVNQDNLVAIKSFGQTNFEGTPLAYALLELTDASLADILAERALTPQEAHEVASSLLAALQALHASGLVHEHIEPANVMAVGEVIKLRSDCVRECILNPDDATPAHCAELKQRDVHDLAVLLLQVLTLQKKLTPAIKLPAPFDKIVSYGIDGTWGLTEIDAALHPPVIKPLVPESVIAAATQQHPQRISPSPQSESPNPALHVRRISNTVQPAPRSMAFWAACSAGALVLIFLAWLFLHGSSKPATPVPTAAVVTPAKPQTIDDAPTPKLSASASTDGVVHTAVATSQTQAGWHVVAFTYNREDQAWHKVATIRDAHPALSPEVFAPSGRGPFLVALGGAMSESEANVMRNKARRDGMPRDTFIRRYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ94</accession>
    <name>E8WZ94_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0625"/>
    <dbReference type="EnsemblBacteria" id="ADW67696">
        <property type="protein sequence ID" value="ADW67696"/>
        <property type="gene ID" value="AciX9_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0625"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_0"/>
    <dbReference type="OMA" id="MPDLFNY"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="256"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="480" mass="52275" checksum="114DF37A36A93CB3" modified="2011-04-05" version="1">MPHPTDPRALIAIDLGAESCRVSLLRWIDSKPTLTLVHRFPNSPRETPQGLRWDLAHIKKGLHQGLTEAAALAPEGIRSIAVDGWAVDYVRLNESSVATADPYCYRDERTLASEAALHKIISADRMREITGIGILRINTLYQQSADTPDNQQRPWLNLPEYILHTLGARPVAEYTNATHTQMIDLATRTWSSEILTAASLPITTFPELVPPGTQLGRLTGPLAALPAYKDTILIAPATHDTASAIAGIPAHGDDWAYISSGTWSLVGTLLETPSNHPEAAADNFTNLGAAGGLTCFHKNVNGMWLIRQSIDFWCENGQTWTVQDLVAAAEKLPAPTDLLDVDDPDLLLPGHMPQRINKQLTTRSLPKIDENDAPAIANLIFHSLAARYAQVLIHIALHSGKTFRRLFLVGGGSQNLFLNRLTEAATGLQVHRGSQESSTLGNFAIQLASLETPEGTPITPAQISHWAQVLEHAPHTAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZE2</accession>
    <name>E8WZE2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ordered locus">AciX9_1782</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580149.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1782"/>
    <dbReference type="EnsemblBacteria" id="ADW68830">
        <property type="protein sequence ID" value="ADW68830"/>
        <property type="gene ID" value="AciX9_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1782"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_0_1_0"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADW68830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="37730" checksum="C7C639D248A94D50" modified="2011-04-05" version="1">MQIEQNIPLAPYTTLRIGGPARYFAQATTEADLIEAITFARTNDLPLFILGGGSNLLVSDAGFPGLVLQAALAPNALHIAPPINGEITYTVPAGYDWDAFVLATSQAGLTGIESLAGIPGMVGGSPVQNIGAYGQEVSQTISAVHALDLETLTPRTFSREDCGFAYRTSIFNSTHRNRYIITAVEFTFALAATPTLTYADLKKHFAATTNPTPLEIYEAVRAIRRTKGMLILPTDAEPDFRSAGSFFKNPIVPAATLNHIAVALSIAPEKIPHWPTGPHEIKLPAAWLIEQAGFPKGFTQGNAAISTCHTLALVNHSGQATCADLLALRDTITQKVQSLFEIPLHQEPVYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ7</accession>
    <name>E8WZJ7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="9" type="ordered locus">AciX9_2948</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581286.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2948"/>
    <dbReference type="EnsemblBacteria" id="ADW69971">
        <property type="protein sequence ID" value="ADW69971"/>
        <property type="gene ID" value="AciX9_2948"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2948"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_0"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="16371" checksum="21CA97A29275537D" modified="2011-04-05" version="1">MLSPKKVKYRKQQRGRMKGKAWRGSDISFGDFGLKVMECGYITDRQIEASRIAMTRFIKRGGKVWLRIFPDKPITKKPAETRMGKGKGAPDHWVCVVRPGRILFEMEGVTPELAKEAMRLAAHKLPLKTSFVMRHDVKATVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK5</accession>
    <name>E8WZK5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ordered locus">AciX9_2956</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581294.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2956"/>
    <dbReference type="EnsemblBacteria" id="ADW69979">
        <property type="protein sequence ID" value="ADW69979"/>
        <property type="gene ID" value="AciX9_2956"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2956"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_0"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="105" mass="11872" checksum="2607C3E43BCCB93E" modified="2011-04-05" version="1">MAGQRIRIRLKAYDYRVLDTSTGEIVETAKRTGAQVAGPIPLPTMKNKYCVLRSPHVDKKSREAFEIRTHKRLIDILEPTQQTVDALMKLDLPAGVDVEIKTVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN7</accession>
    <name>E8WZN7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2988</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2988"/>
    <dbReference type="EnsemblBacteria" id="ADW70011">
        <property type="protein sequence ID" value="ADW70011"/>
        <property type="gene ID" value="AciX9_2988"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2988"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_0"/>
    <dbReference type="OMA" id="CAFERVE"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="485" mass="51764" checksum="EDF3FE97BC7C0573" modified="2011-04-05" version="1">MSIEGSQSTPVAVLQPRPKIVVMKFGGTSVEDAAAIKRTAAIVKGRRDMGHQPIVVVSAMARVTDQLLAAAAAAGRNDREAALSISFKLRERHLETASELVGRHIDEVAHQIHQNFDSLDDLLRGIAAVGELTPRTNDLVVSFGERLSSMIVAHTFEHRGLAGAHIDARTCIITDSHYGKAAPNEAAIEAALHQHLLPLVEAKAIPVLGGFIGSNAEGITTTLGRGGSDYTAALVGGGLHAGAIEIWTDVNGIMTTDPRIVPEALRVKTISFEEAAELAYFGAKVLHPATILPAVQKSIPVWVLNSRNAANEGTKITAVAARCASPFKSIAAKKRLTIIDIVASRMLMAHGFLKAVFDVFDKYSCAIDMVSTSEVSISLTVDSNEQLPAICAELGKIADVKYEGRKALICLVGEDIRGHNGIAGRVFTAVSHVNVRMISQGASEINMSFMIDEEDVEEAVRSLHKAFFTNPDETVFDVASQSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X081</accession>
    <name>E8X081_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ordered locus">AciX9_3042</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581376.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3042"/>
    <dbReference type="EnsemblBacteria" id="ADW70062">
        <property type="protein sequence ID" value="ADW70062"/>
        <property type="gene ID" value="AciX9_3042"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3042"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_3_0_0"/>
    <dbReference type="OMA" id="QTHAHAV"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="185" mass="20664" checksum="338008D1C8A0997B" modified="2011-04-05" version="1">MSIPATQMRPGMIIKYNSDLHLVFSVEHRTPGNLRAFIQAKLRNVRTGAMFTERFRSPDPIDRVYVDEIKMEFLYSDGEDYYFMDDSFEQTMLKRETLGDAVDYLTPNLSISVSFHDGKAVGIELPTAVIMTVLQTEPGIKSATASSVTKPATTETGLVVQVPPFINEGEKIRVDTAEGAYMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E2</accession>
    <name>E8X0E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0736</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67806">
        <property type="protein sequence ID" value="ADW67806"/>
        <property type="gene ID" value="AciX9_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0736"/>
    <dbReference type="HOGENOM" id="CLU_3043934_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="5897" checksum="361E39443BF94FD0" modified="2011-04-05" version="1">MESHLGIIEVDYENDQSLLINFSDGTFASFSVLDLAAMQPNRILADGDHAETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F1</accession>
    <name>E8X0F1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0745</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579141.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0745"/>
    <dbReference type="EnsemblBacteria" id="ADW67815">
        <property type="protein sequence ID" value="ADW67815"/>
        <property type="gene ID" value="AciX9_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0745"/>
    <dbReference type="eggNOG" id="COG4818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359831_0_0_0"/>
    <dbReference type="OMA" id="FARYHAN"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="183" mass="19015" checksum="A7416D8B7F051695" modified="2011-04-05" version="1">MQCAICHAEVGPQSAFCNSCGAPVAAAAAGPADTSGYSTVNAGAPPVGYAAPPAYGAAPPYTGPTAASSGLSDNVASALAYVTIIPAIIFLVLEPYNKVPLIKFHSWQSIGLCVASIVIQIALTILQIALHFIPLIGLLFVPVHLLVGLGIFLLWIFVIIKASRGEWYKLPVIGDFAEKQARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G7</accession>
    <name>E8X0G7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0762</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579157.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0762"/>
    <dbReference type="EnsemblBacteria" id="ADW67831">
        <property type="protein sequence ID" value="ADW67831"/>
        <property type="gene ID" value="AciX9_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0762"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_5_0_0"/>
    <dbReference type="OMA" id="PWCRGGL"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="304"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="641"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="806" mass="89945" checksum="8153EBDF4BD55EF5" modified="2011-04-05" version="1">MEVSRRSFLVGSAAVCAATGLHAPLLASVLQSSDDARNVRLEDGWEFYKGPLDGRFQVWHSEELVTWQKIAMPHCFNAYDACDPDTPAYRGVGWYRMKLKVTNPSSDGRTVLHFEGAGQRSEVWIGNERVGSHSGGYDEFVVDITDACAKTKGAEVQLAVRCDNERDIERMPSDLSDFTLYGGLYRAVHLVYLPAVSLEAVHTRVEFEPGKVAKIAVNGRLYGTGGVGVVLRLSLFDPQGKRVFEKTVERRAWTGEETFASFDLPQPQLWSTKTPSLYRCEVELNGVTVAHRFGVRHTRWEDHGPFFLNGERLAIRGTQRHEDHAGYAAAMPEELIRQEIRLMKEMGANFLRLAHYQQSRVVLEMCDELGIMVWEEVPWCRSGVGTKLFQERGKTQLTNMIDQHRNHACVVIWGLGNEDDWPGELNGEDHAAIRAYMTELRELSHKMDPERMTGYRRCDFAKDIPDVYSPSIWAGWYGGVYTEYKATLEKARPTVKHLLHVEWGADSHAGRHAEEPDAVLKQALADKDVAEKGLDYKLTGGAARVSKDGTWSETYACDLFDWYLKTLEELPWLPGAVQWVFKDFTTPLRVDNPVPRVNQKGLLTRDMVPKEGYFVFQSYWGERPMVRVYGHDWPVRWGKVGQERMVRVYSNCAEVELFLNGKSVGKKKRNAEDFPAAGLRWNLAFAAGKNELRAVGVGGVADTVSFEYQSAVWGKAEKLVLAVKSKGSGGTTVEALLLDAAGVRCLDSRAVVRFSLAGDGVLKDNLGTPTGSRVVQMYNGRAEITVAGTGMVGVVSDGVTAGFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I8</accession>
    <name>E8X0I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipocalin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0783</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579178.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0783"/>
    <dbReference type="EnsemblBacteria" id="ADW67852">
        <property type="protein sequence ID" value="ADW67852"/>
        <property type="gene ID" value="AciX9_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0783"/>
    <dbReference type="eggNOG" id="COG3040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_3_1_0"/>
    <dbReference type="OMA" id="YSCTTIV"/>
    <dbReference type="OrthoDB" id="1770932at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="2">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="187" mass="20611" checksum="55EE61FBFB77A5AB" modified="2011-04-05" version="1">MMRIVAGLVLGAFAAVGARGQSVIPLQKLDLKKFTGTWYEVALLPDKKQKTCVADAVVLFSEKNKPRQFELVNSCLMKNGFSNVRNGDGKQDKQEDGKLKVIYLWPFSVKHWVLAADPDYQWALVGTPNHKNLYVLTKDKTPSDALMAELKAKASAQGFDVGKLIMMPQKRPPTMTTGENSGTSAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J5</accession>
    <name>E8X0J5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579185.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0790"/>
    <dbReference type="EnsemblBacteria" id="ADW67859">
        <property type="protein sequence ID" value="ADW67859"/>
        <property type="gene ID" value="AciX9_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0790"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022180_0_0_0"/>
    <dbReference type="OMA" id="HFRIWVS"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="659" mass="73385" checksum="208B8EE2ADA94017" modified="2011-04-05" version="1">MKLIKARIINFRSIEDSNDVQIEPTVTVLVGQNDSGKTGFLQALDRTNSVNPKQTFNPIEDYPRRYLTKYERELAKDPPVVVQLTYSASSGEIASINNDLGPVVGDPFFFSVDFKYGGGKAIGLSVNESPLISQILAIDPLKLLAAPELGKTSTLRQFFTKLEAIDLNEAAKAQIDALRAKFLPGADNWDSLLSYYIYKQYVASRLPQFVYFDDYKLLPGKVNLPSFQQRVAAAIAQKKALSDQDSTVQALLRMAGISLEELNSPTNYETIKAKLESFSNDITDRVFKYWKQNTELDVLFDIKSDANDLAPFNSGNNLYIRIASRRHRMSMPFDRRSKGFIWFFSFIIWFASVKEEVNAKNDLVLLLDEPGLSLHALAQADFLGYIRELSSDYQVIYTTHSPFMVDSDKLLEVRVVQDQDGSGTKISSNLSGSDPKTLFPLQAALGYTIAQNLFISTRNLLVEGPSELLYFKHFSALLEAAKRVSLREDITIVPTGGLDKVATFVSLLGASGLEIVVLHDYEKNNAQNLADIIKLKAIDQKKVRTFSEYRPGAAKGENSPTDIEDLLPVSMYLAAFNKTYSGSLKKEISEGKLPAGERIVDRINRYLIAAKESVRPSGGFNHYLVSQTICTTVPDSQNESAVLSAFEAMFKSVNALFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0K0</accession>
    <name>E8X0K0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_0796</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0796"/>
    <dbReference type="EnsemblBacteria" id="ADW67864">
        <property type="protein sequence ID" value="ADW67864"/>
        <property type="gene ID" value="AciX9_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0796"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="IPITRAH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="350"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="593" mass="64011" checksum="2066DF198608781D" modified="2011-04-05" version="1">MNARRGIPARAGTAKRDPGMSLLWESLRSQPLRMLTGLMLIGVNRAAFLVLPGSLGLMVDRVLVKHQSSAMPSILAAVAGATALQTLTGLMLDLLLGYSCQNAIASMRTRVQAHIMDLPTSFFDHQLSGVLAARVMKDSEKLRDFIGPVALESVAAIVTGGLAFGGMIFLSVKLTLPLVVLLAVLAGVMRWAAGDVRARYAEIAHLQSIMAGRLSESIAGVRVVKAYAAEPREAIVFASQSQVLEDATVQVQMHQARSTAGASLAFSLIGLLLLYAGTLQVLAGALTVGRLVTYCAFLACATQAARQVGGLRMQFASSLASLDRIASILRESPEDAGKRHPEVPPVTGVVRVHGVSFAYTPAQTVLHDISFTATPGTLTALVGSSGSGKSTLCALLCAFYRPTSGSVLIDDVNLASRSLGDFRDQLGVVFQDPFLFSGSIRENVLIARPSATEAELMECYELVRLDRFVDRLPDRYETLVGERGVRLSGGERQRICMARALLRDPRLLLLDEPTSSLDEESEHYFRETLGHLIPRRTAIVIAHRLSTIRRADQILVLDSGRIVERGDHLTLMALRGHYFRLFQSQPGAHDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L1</accession>
    <name>E8X0L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1916</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1916"/>
    <dbReference type="EnsemblBacteria" id="ADW68962">
        <property type="protein sequence ID" value="ADW68962"/>
        <property type="gene ID" value="AciX9_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1916"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696243_0_0_0"/>
    <dbReference type="OMA" id="GIQQFAV"/>
    <dbReference type="OrthoDB" id="765785at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="437" mass="48356" checksum="A8845E5CBC03059A" modified="2011-04-05" version="1">MPPAPQSNRNETPHSEHLTKDAPISRRTGQALRLFQRFLPLALVAALASTALAQAPNPHTDPLNFDPVVRDAYNHFYNLDYDGALSRFEQVLKANPQNPMAADYVLMVTIFRELYHQDLLDTTYYAHDSFLTTQRKVEVPDPTRQRIESLLAQVQDQVDQRLKANPNDPNAKNLLFARGYARGLHAAFITLADHSFFAAARQGLAARNDSEAALKLDRDYADANMAIGIQQFAVASLPRLVRMMVGIAGVGGNKEHGLELLHISAEHGVVTQVESRTTLSLFLRHDGRYAEALAMQHGLATQFPHDYLFRLEEANLTKDKGDGPGAIAIYKQVLADAHKPGYFADPRLQMAWFGLADTERGQNDIADAAKHYLEAANQPNASDWIRKRANLNAGQMLDLLHDHNAAVAQYQKAAAPGGDQSQADAARKLIKTPYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U3</accession>
    <name>E8X0U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP family containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3111</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3111"/>
    <dbReference type="EnsemblBacteria" id="ADW70127">
        <property type="protein sequence ID" value="ADW70127"/>
        <property type="gene ID" value="AciX9_3111"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3111"/>
    <dbReference type="HOGENOM" id="CLU_2105524_0_0_0"/>
    <dbReference type="OrthoDB" id="1925073at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="13068" checksum="C6B6EDD7AD263126" modified="2011-04-05" version="1">MVYHAVPGKVQNLESVFEGVSGLQDKHGLKVVGYWTPKSEDPARRDTFVYLLDHSDRATAEKNWQALHADPLFTPFRQAAIPLIRQKDSEYLVDAVYMSSAFYSSFKRRSRSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z0</accession>
    <name>E8X0Z0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3163</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70174">
        <property type="protein sequence ID" value="ADW70174"/>
        <property type="gene ID" value="AciX9_3163"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3163"/>
    <dbReference type="eggNOG" id="ENOG502ZWQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2493545_0_0_0"/>
    <dbReference type="OrthoDB" id="2099535at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9581" checksum="31A14975446583F2" modified="2011-04-05" version="1">MLRWGQDHMECETMIECKEAAGRIVRSLKLFEDGPYGPEIGIEFEDGSTFTATLHARHVLEGKLTRDDGGEPVILHQCVTPPVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Z7</accession>
    <name>E8X0Z7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase like protein, AhpD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581493.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3170"/>
    <dbReference type="EnsemblBacteria" id="ADW70181">
        <property type="protein sequence ID" value="ADW70181"/>
        <property type="gene ID" value="AciX9_3170"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3170"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_5_1_0"/>
    <dbReference type="OMA" id="HTGIAKM"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20155" checksum="15453121077989F4" modified="2011-04-05" version="1">MNTQVALFSPVDLETAPEKSRPLLENVQKSFKFIPNLFGVFANSPVLLEGYMALEKAFDKGSLNAVERQIILLSASVENRCGYCIAAHSTVLKAFLHAPAEVVSAVRANEPVSDPKLQALVALTKEIVTERGHVSEQVMDNFLAAGYRKDQVLEVLIGVALKTMSNYLDHISHTELDPAFQSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X147</accession>
    <name>E8X147_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LprI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0845</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579238.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67913">
        <property type="protein sequence ID" value="ADW67913"/>
        <property type="gene ID" value="AciX9_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0845"/>
    <dbReference type="eggNOG" id="COG4461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022184_0_0_0"/>
    <dbReference type="OrthoDB" id="1517357at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009739">
        <property type="entry name" value="LprI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07007">
        <property type="entry name" value="LprI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230545" description="LprI domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="LprI" evidence="2">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="28958" checksum="29A004A5D7ADD18B" modified="2011-04-05" version="1">MTKSSFRNIAASILALATVTAAADCTKAITPIDKTVCQTPELTKLDADLNHLYTALRPQLTIGAKARLLTQQRTWLALRDKTCATADAACLQHQYADRLDQLEAINASAKAADDKLDDVTPVYLKGSWKVTAIHDPAGRGHTNPTALKQSLEDEELSPPGSTVVAAPGELCFPPDPCGDMAWDFPPLGKVASGSAIIEQLGLTPATRALRGSSGTINSHYLLIPRPDGSLWAAFILCGPAVGQDCRTAAEVWTPATPDARVFPTHFPSATYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8X150</accession>
    <name>E8X150_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">der</name>
        <name evidence="12" type="ordered locus">AciX9_0848</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579241.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0848"/>
    <dbReference type="EnsemblBacteria" id="ADW67916">
        <property type="protein sequence ID" value="ADW67916"/>
        <property type="gene ID" value="AciX9_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0848"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_0"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="140"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="347"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="146"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="400"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="465"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="622" mass="68772" checksum="1D5E94A51C251C00" modified="2011-04-05" version="1">MAAKKAAKRLGKKHRQASTRPHKGKAPKSGVTTGATRIGAVDPKKRKIIATKKAKVVAEKRISKRSPEFEAKRTITGDDPEKTVGKNSAKVPQDRPMREPRRPSGRILAGPKDDDDWREAELAALQQSVVTESAASLALPLIAVCGRPNVGKSTLFNRLTGSRRSIVGDEPGITRDRIYGEIEWQNVKARLVDTGGVVPDDEALIPSEIFRQAQVALQEADAIVMVVDGRTELASPDMELARLLMKGGKPTFLAVNKMDSESMYAAAENFRRLGFKNVLPISAEHGSGIGDLLDEVFAVLPEPAEGLEIEEEPEFEPFDEEIEAAEGEEPVRVRTQRTHGEYESRETKVAIIGRPNVGKSTLLNALTETDRAIVSPIAGTTRDAVDEIVEKKGHIFRFVDTAGIRKKGKTKMMAEKLSVIMARKHLEAADVSLLVIDAQEGVTNIDANIGGYAHESGRSVIIVINKWDLVTTARTDGKPAADQKAYAQQVRDALKYLDYAPLLFISAGPETGGPKAIEQVFAKVELVARERRKRVSTGMMNKFLDKVDFQRASVPMNKRVKIYYMTQAQVAPPTFVLFTDRDIKMHFSFERFLANQIREAFGFIGSPIWFKIRARNKKKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X156</accession>
    <name>E8X156_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ordered locus">AciX9_0854</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579247.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0854"/>
    <dbReference type="EnsemblBacteria" id="ADW67922">
        <property type="protein sequence ID" value="ADW67922"/>
        <property type="gene ID" value="AciX9_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0854"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_2_0_0"/>
    <dbReference type="OMA" id="CDTEYAF"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="25259" checksum="33EB9E1C25DBA6D3" modified="2011-04-05" version="1">MHLIELYKSVQGESSFTGLPCIFVRFAGCNLRCAWCDSEYTFTGGNPFTQEEVIAQIEALAPCKLVEFTGGEPMLHAKELLPLMDVLLTQGYTLMMETSGERPLDLVPKAVHKIVDVKCPGAGAAANSFRLSNLETLTKNDEVKFVLTNRADYEFARAFIAEHRLNDLAAGVLLSPAFTKNPSPLRTVENATLDPRTLVEWMMHDGVDARLSLQIHKFIWEPMKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X185</accession>
    <name>E8X185_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">AciX9_1994</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1994"/>
    <dbReference type="EnsemblBacteria" id="ADW69039">
        <property type="protein sequence ID" value="ADW69039"/>
        <property type="gene ID" value="AciX9_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1994"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="83" mass="8912" checksum="74F33F84F90EE6C6" modified="2011-04-05" version="1">MVDIERTGAALSEIIKLMVGRPNEVVLSIATTELGKVVYRVTVATDDVGSIIGKNGRTATSLRNVLHVIALRTDLKISLEIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1A2</accession>
    <name>E8X1A2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2011</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2011"/>
    <dbReference type="EnsemblBacteria" id="ADW69056">
        <property type="protein sequence ID" value="ADW69056"/>
        <property type="gene ID" value="AciX9_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2011"/>
    <dbReference type="HOGENOM" id="CLU_2825088_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7666" checksum="75BF89F3873ED4D7" modified="2011-04-05" version="1">MCLLHKMTVEETAFAKEMTWDEFFARFDVLGLAIVYDDSTVFNEILQIDDANPSTPPAYRWVTSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H9</accession>
    <name>E8X1H9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3203</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3203"/>
    <dbReference type="EnsemblBacteria" id="ADW70214">
        <property type="protein sequence ID" value="ADW70214"/>
        <property type="gene ID" value="AciX9_3203"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3203"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="VRAWQHP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="24031" checksum="3AE9425112EA65D7" modified="2011-04-05" version="1">MAQTLSAAMIEQTQRENLAIARGLKRNDPELLDQLIELYQHRLLRYLLFLTGKREVAEDLFQETWMRVLLRGAQYNGKARFDTWLFTIARNLVIDLSRKRQMASLDEMSEAGDDERPFEVAIDEPSPLDQFAVREDRAEVAEVLLKLEPNYREVLVLRFHEEMSLEEIASFTKAPLSTVKSRLYRGLAALKPEVEQLRKAHEGGSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I4</accession>
    <name>E8X1I4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3208</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3208"/>
    <dbReference type="EnsemblBacteria" id="ADW70219">
        <property type="protein sequence ID" value="ADW70219"/>
        <property type="gene ID" value="AciX9_3208"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3208"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_3_0"/>
    <dbReference type="OMA" id="GEWGHNV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="331" mass="34983" checksum="4C05A0E58C5C3633" modified="2011-04-05" version="1">MGFVGYPQQPSALMTQPFSPLRGYNLPDSSSIRIGIDLGGTKIEALALDHAGNELGRHRVPTPRDDYKGTLQAMADLVFRLETETGRKATVGAGIPGTISGVTGLVKNANSTWLNGKPLQEDLGQLLSREVRIANDANCLAVSEATDGAAAGKAVVFAVILGTGCGGGVSFQGHVHSGPNGVSGEWGHMPLPWPSVDENPGPSCYCGKHGCMEQWVSGTGVAQDFRNVTGKSLTTREIVAIAEAGSAEALDTMHRFEDRLARGLAQVVHILDPDIIVFGGGLSQYKGFYRTLGERMIPYVFGGEFDTALVPALHGDSSGVRGAAWLWPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J1</accession>
    <name>E8X1J1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3215</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581538.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3215"/>
    <dbReference type="EnsemblBacteria" id="ADW70226">
        <property type="protein sequence ID" value="ADW70226"/>
        <property type="gene ID" value="AciX9_3215"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3215"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_10_0_0"/>
    <dbReference type="OMA" id="QRPARRY"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="101" mass="11280" checksum="326EABCEA2601E80" modified="2011-04-05" version="1">MATPRLSHTAALILKALSLGYCFGFDVMEITGLPSGTVYPALRRLERDELVESKWEPEAEATAQQRPARRYYEVTRQGREAAVAVTARYPLLAQLVTEKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1L0</accession>
    <name>E8X1L0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S10 serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3234</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3234"/>
    <dbReference type="EnsemblBacteria" id="ADW70245">
        <property type="protein sequence ID" value="ADW70245"/>
        <property type="gene ID" value="AciX9_3234"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3234"/>
    <dbReference type="eggNOG" id="COG2939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032786_0_0_0"/>
    <dbReference type="OMA" id="HMTYLDD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230567" evidence="2">
        <location>
            <begin position="27"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="505" mass="54529" checksum="AC8E2351C3F77E51" modified="2011-04-05" version="1">MYSQHMNCSRIALALTLLAAVPALHAQGKPDHAPEEKPDAAKPMANPLPPDAHVAQTIQLNGAPLKYTATVGTLPVKATDGKPTGEVVFTSYIVDGPNRPVTFAFNGGPGAASVYLNLGAIGPKRVAFGAEGQSPSDPATLTDNPGTWLDFTDLVFIDAIGTGFSQSLVNEAETKKLFYGPDQDIAYLSRIIYDWLVKNGRLQSRKYIVGESYGGYRAPRLTAYLQSNIGVAMNGVIMVSPALAPNGGSPDISPIPWMTTLPSIVAANYERKGMLTDEAMAPVIAYTRGEYAEDILKGTSDPQATPRLVKKVTELTGLDATFVRQSGGRLETQAFLREEFRETGKLGSRYDPNVTAYDPFPYNPTQETNDPILLSIIAPTTTAMVDFVTRTVGWKTDLRYEALSESVNRNWDHSSRSGAFTGSASATDLRVAIATDPKLRVLVAHGWADLSCPFMGSVLTVSQIPIMGDPTRVQVHMYPGGHMYYARTASSLALRKDVMDLVAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T0</accession>
    <name>E8X1T0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0932"/>
    <dbReference type="EnsemblBacteria" id="ADW67999">
        <property type="protein sequence ID" value="ADW67999"/>
        <property type="gene ID" value="AciX9_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0932"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_0_1_0"/>
    <dbReference type="OMA" id="FDRMLIC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09872">
        <property type="entry name" value="PIN_Sll0205-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041705">
        <property type="entry name" value="PIN_Sll0205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14760" checksum="6EBA14DB8D22F008" modified="2011-04-05" version="1">MDLLLDSHPMLWSMYEPERLSPSVASLIFDRTNRLFASLGSIMDISHKAAFHKLPLVGSNVYKLLEQLRKYDCTILPITQPDVLAATALPLIHGDPFDRLYIAQAQRHRLTILTKDEHMKKYDVQTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T4</accession>
    <name>E8X1T4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579327.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0936"/>
    <dbReference type="EnsemblBacteria" id="ADW68003">
        <property type="protein sequence ID" value="ADW68003"/>
        <property type="gene ID" value="AciX9_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0936"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_3_1_0"/>
    <dbReference type="OMA" id="MHDAKTH"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9262" checksum="042D135F7CFD7164" modified="2011-04-05" version="1">MEVNVHHAKTHLSKLIAAAESGEEVIIARAGKAVVRMVPVAPPACKSSKNLRGSGIGKIWLAPDWDSDETNLEIQKLFEGSASGDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V6</accession>
    <name>E8X1V6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2072</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580434.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2072"/>
    <dbReference type="EnsemblBacteria" id="ADW69117">
        <property type="protein sequence ID" value="ADW69117"/>
        <property type="gene ID" value="AciX9_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2072"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619420_0_0_0"/>
    <dbReference type="OMA" id="VFPHEVV"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="425" mass="47047" checksum="9F1481E3277C3AA4" modified="2011-04-05" version="1">MSLFFSVGSPETELSEAEIRDGLFSALGMLGERKRVLAVPPDFTRMHSKSGMLTEMASAYYGDRLVDVLPALGTHKPMTDAEISTMFGATPRELFRVHDWRNDIVTLGEVPGEFMADVSEGKLDYTWPAQVNKLLRDGGHDLILSIGQVVPHEVVGFANGSKNIFVGTGGVMGIHRSHFLGAVYGMERMMGRADTPVRRVLNYASAHFTNELPQIVYVQTVVNKNAAGKLVMRGLYISDDDQAFELAAALSLKCNFLMMDREIKKAVVFLDPQEFRSTWLGNKSVYRTRMALADDAELIVLAPGVHEFGEDAAIDTLIRRYGYCGTPATLDAVKEDAELAANLSAAAHLIHGSSEWRFTIRYCPGHLTQEEIEGVHFAYGDLATYTAKYDPEKLVDGWNVVDGEEIFFISNPGLGLWAYEGRFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W7</accession>
    <name>E8X1W7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2084</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580445.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2084"/>
    <dbReference type="EnsemblBacteria" id="ADW69128">
        <property type="protein sequence ID" value="ADW69128"/>
        <property type="gene ID" value="AciX9_2084"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2084"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109379_0_0_0"/>
    <dbReference type="OMA" id="DAQFNRK"/>
    <dbReference type="OrthoDB" id="1564766at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="21093" checksum="E019D8EFD1EB3C1E" modified="2011-04-05" version="1">MVEAITPSERQLVLDQLSTSEQRLLELATNLNPSQWHFQESPDRWSIAEIIEHCIVFERFITGVITNALATPATTEKKPEAPTKEPWVQGLAQSRHTRFKSREVNLPTGRWPNPIDLIAELRQTRAQTLHFASETQSPLRDHFFPHIAFGDLDCYQWLVVTAQHTARHAHQIEEIKSNPAYPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Y7</accession>
    <name>E8X1Y7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2104</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580464.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2104"/>
    <dbReference type="EnsemblBacteria" id="ADW69148">
        <property type="protein sequence ID" value="ADW69148"/>
        <property type="gene ID" value="AciX9_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2104"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_0"/>
    <dbReference type="OMA" id="CITRGMR"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="28479" checksum="A18B609F982A2BE5" modified="2011-04-05" version="1">MTVIDISSTEPLVMEEGAREGNTAIRMILADSQAIYRVGMRKVFALEDDIRVVAQAETLQNLYAALQRFPTDVVVLEGQLISGTVDAIPELVRRAPEAKLIVQLSESDEANTVELYRRGVRGVVPRSISPDLLIKCVRKIAAGETWIDNQSVSWVIEAYRAQATSLTGPRTQPKLSKKELAIIGCITRGMRNKEIAYQIGTTEQVIKNYLRKVYDKLGVSDRLELALYCLHHQLLKKYNQEAEDTILANGTHQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X244</accession>
    <name>E8X244_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein UCP028291</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3276</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581599.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3276"/>
    <dbReference type="EnsemblBacteria" id="ADW70287">
        <property type="protein sequence ID" value="ADW70287"/>
        <property type="gene ID" value="AciX9_3276"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3276"/>
    <dbReference type="eggNOG" id="COG3553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127482_1_1_0"/>
    <dbReference type="OMA" id="KLCKHYA"/>
    <dbReference type="OrthoDB" id="1858344at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014543">
        <property type="entry name" value="UCP028291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09981">
        <property type="entry name" value="DUF2218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028291">
        <property type="entry name" value="UCP028291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10836" checksum="C4E832FDB1A79C9F" modified="2011-04-05" version="1">MKRSEALVATENGVKYMKQLCRHWGHKFTVEFDETHGRIELPQTVCTLDVLPAALKVSLDVAGDGDLKRMETVVEEHVKRFAFNEELAFSWASEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X275</accession>
    <name>E8X275_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3307</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581630.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3307"/>
    <dbReference type="EnsemblBacteria" id="ADW70318">
        <property type="protein sequence ID" value="ADW70318"/>
        <property type="gene ID" value="AciX9_3307"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3307"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="GVPRSEH"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="55509" checksum="F20DD26D2F856B62" modified="2011-04-05" version="1">MKSLTRREFSWGAATALFATQAFLNSPRAHASDPAETDLTKLTLAEASARIHAGTVTSTQLTKACLDRIAIYDPKLDAFITVMRDKALAQAAILDAEQKAGKLRGPLHGIPVALKDNIDTAGTRTTAASGVFQDRVPAEDAPVTTRLKAAGAVIIGKTNLHEFAMGAGEASFFGAARNPWALDHNTGGSSSGSGAAMSADLCYGSLGTDTAGSIRNPGAFCGVVGIKPTYGLVPIRGIAPLCVSLDHCGPITRTVEDAAMMLNVLAGYDHLDITSVEHAKEDYVAGMKQPIKGLRLGIPIGAFDGVDPQVGQLVHTAIELLATLTRGVKEVSLPSTNDVAYQNFASMGETFAYHEQFFKLQSNRYQPVDRRRLEAEEATHPRAEDYIRLRWELETLRRTIDDAFTDFDLVLMPTQKVTAPVLDDMLRRNLQPTTTPLTSSSTAGGGSSVGAYNAYGIPSLTVPCGFSKEGLPVGLMICGPHFSESKVLALAHAYEQATAWHTMKPPITPDTVVPPLITHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2H6</accession>
    <name>E8X2H6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ordered locus">AciX9_2156</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2156"/>
    <dbReference type="EnsemblBacteria" id="ADW69200">
        <property type="protein sequence ID" value="ADW69200"/>
        <property type="gene ID" value="AciX9_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2156"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_2_0"/>
    <dbReference type="OMA" id="ERRYKHI"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="231"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="544" mass="59414" checksum="F58D0D479DB4770F" modified="2011-04-05" version="1">MTMTRAKITSARELPAGSSLALATLAGCLWFLSAPPFRFAGGAWIAMLPLMFVLDQTLSFQRAVWFSSWTGLVGNMGGFYWLFQTIRRFAHLPWPIALLLFLAICLYQGLTFTLFGAAVHFARHRRTIPMALLAPLAMVTAEWIEPMVFPDSLAITQAWHPLVIQIADITGPLGVCALLLLINGALYDLIVSTRRAVVPAVISAMILIASLLYGAIRIRQVDAISNAAAKLRVGIVQPNFAHTEKGSQNPQPASERLAILQEQSRELEAAGAQLIVWSETSYPFALQRRKGVVAVDPSPAIMRGFHTPVIIGANISDTAAQKHFNSALLVDRGGNIAGVYDKVRLMNFGERIPAGEILPWLTDLLPRDYARFTPGSTATPLPFRNDDGTVLRLGTFICFEDILPDFLRLVGANHPQLLVNLTNDSWFGDTSEPWEHLALSVFAAVEQRTAMARSVNSGVSAFIDANGRVLQKTYAVDPSLHSQPASHMLATLPLIEGGHTFYERGGHLFGGLCSLCLLLLLAIPPCVKHLRHIATLRGLDVECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I9</accession>
    <name>E8X2I9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2169</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580529.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2169"/>
    <dbReference type="EnsemblBacteria" id="ADW69213">
        <property type="protein sequence ID" value="ADW69213"/>
        <property type="gene ID" value="AciX9_2169"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2169"/>
    <dbReference type="eggNOG" id="ENOG502ZGH0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756251_0_0_0"/>
    <dbReference type="OrthoDB" id="2098474at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15518" checksum="15CF9BC03913E239" modified="2011-04-05" version="1">MKNVFPRRRTHQLSIQQVGQETLIYDEQTHNAFCLNPVAAAVWNLCDGETSAAVISVSASFALKLTVSEELVQLSLEALASDGLLESESPPPAPATISRRAAVSQLGVGAAMLLPVIAVIAAPKAAQAYTGCVNCTAPSSTGTRGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J8</accession>
    <name>E8X2J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580538.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2178"/>
    <dbReference type="EnsemblBacteria" id="ADW69222">
        <property type="protein sequence ID" value="ADW69222"/>
        <property type="gene ID" value="AciX9_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2178"/>
    <dbReference type="eggNOG" id="ENOG5033CI2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2829819_0_0_0"/>
    <dbReference type="OMA" id="FANRCPE"/>
    <dbReference type="OrthoDB" id="2044315at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8407" checksum="0630F3D78559A062" modified="2011-04-05" version="1">MAFPIKVCAVCSEEFELKPDKPGFANRCPECSAPKEEEPATKKRMDADERKSLSEANEARRTAMRELLYRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K7</accession>
    <name>E8X2K7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2187</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580547.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2187"/>
    <dbReference type="EnsemblBacteria" id="ADW69231">
        <property type="protein sequence ID" value="ADW69231"/>
        <property type="gene ID" value="AciX9_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2187"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_0"/>
    <dbReference type="OMA" id="LTYCGYD"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="385" mass="41498" checksum="135D0F02C232CD4A" modified="2011-04-05" version="1">MSEAVAEVGFKPKKSVALSGTPAGNTALCTVGRNGSELRYRGYGIADLAGRCGYEEVAYLLIHGRLPNVAEIGSYKAKLKGLRGLPASVKAALELLPAATHPMDVLRTYVAVLGCVLPEKDGHKVAEAREIADGLIASMPSALLYWYHFSRHGRRIEVETEDDSIAGHFLHLLHGCAASAEWVGAMETALILYAEHEFNASTFAARVIAGTGSDLYSCVAGAIGALKGPKHGGANEVALEIQSEFASADEAEVEIRKRVEAREVIIGFGHPVYTVSDPRNKIIKEVARGLAAGAGTTGLFDIAERIEAVMWDAKKMFPNLDWFSAVAFHVMRVPTAMFTPLFVMARTAGWAAHVIEQRQDGKIIRPAANYTGPDEVRFVPLEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q3</accession>
    <name>E8X2Q3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3342</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581662.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70350">
        <property type="protein sequence ID" value="ADW70350"/>
        <property type="gene ID" value="AciX9_3342"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3342"/>
    <dbReference type="eggNOG" id="ENOG5030KZN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098524_0_0_0"/>
    <dbReference type="OrthoDB" id="1465841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026349">
        <property type="entry name" value="CHP04255"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04255">
        <property type="entry name" value="sporadTIGR04255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="28494" checksum="2BFFDD5D85E1D475" modified="2011-04-05" version="1">MTPMSSPPNSVRFINPPIVEAIIAVTITQLPDDSLQKLLEISEGVAALGYALKTTMTSHEMELAIQDGVSKASNHDQVNGYQFISSDQRFAFQVLKTGMIFSQLGRYESWELFTQEAQKIWKIYLGHIGAVELQEFVVRYINKILVPLGEPSERYIKLYIEVPQELPQVVMNPYLRLSFIIAEPAGTLVHQQGLLPKEVEGFVSTLLDNTFTFPIAGLGLDELWPKIDSVREIKDHFFLNMLTDKMKESFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2R0</accession>
    <name>E8X2R0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3349</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581669.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70357">
        <property type="protein sequence ID" value="ADW70357"/>
        <property type="gene ID" value="AciX9_3349"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3349"/>
    <dbReference type="eggNOG" id="ENOG50348NN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107177_0_0_0"/>
    <dbReference type="OMA" id="PALDIRY"/>
    <dbReference type="OrthoDB" id="2063385at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234304" evidence="1">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="195" mass="21377" checksum="198445A77F1E353A" modified="2011-04-05" version="1">MICNILRRLATTTFAATAFLASASLLQAQSFATAARTVSISAFAGASRVNTDYGSTNAGYLFGADFTRHYHLVDPSLEVRATIAPGSSIGEKTFSGGLRLQKRFHRFQPYADLLAGAGSITFNHPTVVNGIPYASDNSFIYVFGGGMDYYVTRNFAVKADYNQQLWRLGQNLNRLTPSALTIGIVYRIPFHPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E7</accession>
    <name>E8X3E7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3443"/>
    <dbReference type="EnsemblBacteria" id="ADW70448">
        <property type="protein sequence ID" value="ADW70448"/>
        <property type="gene ID" value="AciX9_3443"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3443"/>
    <dbReference type="eggNOG" id="COG5642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109353_5_1_0"/>
    <dbReference type="OMA" id="FVIPQRT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011979">
        <property type="entry name" value="Antitox_Xre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024467">
        <property type="entry name" value="Xre/MbcA/ParS-like_toxin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09722">
        <property type="entry name" value="DUF2384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02293">
        <property type="entry name" value="TAS_TIGR02293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2384" evidence="1">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="149" mass="17068" checksum="E198961F016AE6E9" modified="2011-04-05" version="1">MTVQAIPQRQPAVFYRRLESKLGVSPLDSDRDIARFVEARLPLTSVDALSSHGITTEEIYDYILPRRTLVHRRTRHEALTHEESDRAVRLARIASLAEEVFGEDAKAARWLRKPKTRFEGRTPLELLRTEAGARLIEEMLLQLDFGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L6</accession>
    <name>E8X3L6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1144</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579530.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1144"/>
    <dbReference type="EnsemblBacteria" id="ADW68207">
        <property type="protein sequence ID" value="ADW68207"/>
        <property type="gene ID" value="AciX9_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1144"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_0"/>
    <dbReference type="OMA" id="LFMNEEN"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230634" evidence="7">
        <location>
            <begin position="22"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="8">
        <location>
            <begin position="267"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="505" mass="52351" checksum="AC91C079640E7E8B" modified="2011-04-05" version="1">MTRVCSALLLAGLVGLTPALAQRGGVGLPGVSGPVTAQYQADATRILAAAATDTDGYAALTYLCDRIGNRNSGTPQLNAAVQWGAELMKKAGLQNVTIQPAMVPHWVRGKESASIVSPGLNGVPRKLRMLGLGMSVGTPAGGITAEVLFLHDYAELDALPADGAKGKIVVFDPGWHGYGVGTSYRTNGASRAAAKGAVAVLVRSATGLALQAPHTGRLVYDEKAPKIPSAAISVEDAGLIGRLAKDGPVTVHLEMEAHQEADVKSGNVYGDLVGSEHPEDVVVLGGHIDSWDVGQGAQDDGGGIMATFEAVSLLHKLGLKPKRTIRVVFWVNEENGGRGGDAYPVLLGAAAVAKHVAAIEMDGGAEKPLGMGYGTFGMRMGPPKPGAPPQSMTPPGFDLTKLTEPQQASFALLQQIAALLGPIGADKVFPGGGGEDIGPIVAMGVPSLSPHTVGEHYFDWHHSEADTLDKVDLEDFRKNIGMLAVTSFVLADTKETLVGEKLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T7</accession>
    <name>E8X3T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2328</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580681.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2328"/>
    <dbReference type="EnsemblBacteria" id="ADW69365">
        <property type="protein sequence ID" value="ADW69365"/>
        <property type="gene ID" value="AciX9_2328"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2328"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605032_0_0_0"/>
    <dbReference type="OMA" id="IDPCDRA"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="450" mass="50305" checksum="F20156DF0CCBEE80" modified="2011-04-05" version="1">MAEITVTNWFGNIVSHPLVVVDANSVDDIVRVLKDPVQYPSPVRVVGSNHSTSPCGVADGGTLIRMKMNKVLNVGDDTLTVEAGAIHLDLAKMLEAKNLMFYVNTEIGSLSSGSAACAGTKDASMPGEYGQVGSYVTGMKMVLPSGDLLEVTEADQPDLMKKMRCSYGTCGIVYEVTYKIRALLPMAVHHETFELEDFIARLPELKARGESMFYYIFPFDNKITIEFRKYNPGATGDPDHCAWGLRNHFWGSAGPKFGHDVSQNISIPKIRYGILDGFNATWRFQLENLVCGDYTIPGDQIIHYPPVSDDSRYTFSLFAFPEADYAVCISDFFKFVKDYYNEKGYRSNLLYVGYWIMQDQQSLLSYSYNGPVMTIDPVSTANDGWVDFLAAYNQFCSDRNGVPLLNQTYGLTPAIVQKAYGDRLTTMQQTRRSYDPTDRLLNAYFKDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X456</accession>
    <name>E8X456_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0025</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578445.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0025"/>
    <dbReference type="EnsemblBacteria" id="ADW67116">
        <property type="protein sequence ID" value="ADW67116"/>
        <property type="gene ID" value="AciX9_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0025"/>
    <dbReference type="eggNOG" id="ENOG5033T4T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945826_0_0_0"/>
    <dbReference type="OrthoDB" id="1155600at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="294" mass="33268" checksum="A7EBD6F96B268E5E" modified="2011-04-05" version="1">MLAIGFTLLLGAYLFGPGLIARLILGFAVPRKTLVQSRSEEVTRSIVQAVVPFGIALVWARATGALQQSGHLTDLQTVFSGIYSTSFFDAHRQDFFSSLHAFCQMNLCLLLRLYLLVVLFALTLNLAIRNYSQLRARLPLGWQKALLATLVLPRVSEWHVLLSEMLLPAGDFLDADVLTKSSVLYQGRIQDKMLGADGSLQSITLAKPRRFLRDEFEKAKEADPNVDREAYWRSIAGNLFVLMASDVINLNLKYIHRNPIDFRSSQEERIVLRRLLERLSNDETDRDQTDRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X495</accession>
    <name>E8X495_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0064</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0064"/>
    <dbReference type="EnsemblBacteria" id="ADW67155">
        <property type="protein sequence ID" value="ADW67155"/>
        <property type="gene ID" value="AciX9_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0064"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018719_0_0_0"/>
    <dbReference type="OMA" id="CGWFFEE"/>
    <dbReference type="OrthoDB" id="360776at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021923">
        <property type="entry name" value="DUF3536"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12055">
        <property type="entry name" value="DUF3536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="127"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="930" mass="103115" checksum="1D1B53A7381470EE" modified="2011-04-05" version="1">MAKSNRKLDTAPAPAAASPQTPTPTRYVCVHGHFYQPPRENPWLETVEVQDSAAPYHDWNDRITAECYAPNGASRIQNLENEIVRIVNNYSRMSFNFGPTLLSWLQDKAPRTYQMILDADSASAARYSGHGSALAQVYNHIIMPLASTRDAQTQIRWGIADFESRFHRKPEGMWLAETAVNRHVLDLLAQEGILYTILAPNQCARVRNLSASTPADSALAAWTETPNDSVDTTQPYRVQLDEGRSIAVFFYNGPNSRAIAFEGLLDSGEKFGSRLLGGFHPGESSRPQLSHVATDGESYGHHHKHGEMALSFAMHWLEDQHHATLTNYGEFLAKFPPMCEAEVVEDSSWSCAHGVERWRSNCGCNGGKPGWNQLWRKPLRDALDYLRDNTAPLAEKLAKDLLKDLWVARDAYIQVVLDRSTESIDRFFADHAARALTAEERVSVLELMELERHTQLMYTSCGWFFDEISGIETVQIIAYAGRVLQLAAELFGASSKHLEPGFLAILAEAKPNLAELKDGSEVYTRYVTGMRIGLEQVGAHYAISSIFRAYPEDGELFCFDVHRDSHEVFTSGRGKVALGRARIRSRITEEAEEICFAVLHLGDQNLSAAVRRSNPSDEAAFAEFSSEVRSAMRRANLPEVIRLIDRNFAPDRSTAQERASDRAASLRGQAIAPVSAFASNDAAPHVTLDPIHPEPGQAENAPGAVEPGIAHTIDPVEAPPAPVNVPNIPITYSLSSLFADEQHRILQTILNQTIGEMEDSLRNIYEDHASLLHFLTESGMNPPPALALAASFAINASLRRALEAEEFDPQEVADLLARSSTDHVSLDANVLAFAAGQRMKRAMVKLEAAAEHSPQATLAALNSALAIADIIRFMPFEVIIWQAQNIWNDLLRRTDAQYWSEEWKDGFKKLGEAMNIAVDQLVIEEGVTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D2</accession>
    <name>E8X4D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1196</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579582.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1196"/>
    <dbReference type="EnsemblBacteria" id="ADW68259">
        <property type="protein sequence ID" value="ADW68259"/>
        <property type="gene ID" value="AciX9_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1196"/>
    <dbReference type="HOGENOM" id="CLU_2825086_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7583" checksum="FE153B5D8F4BBE84" modified="2011-04-05" version="1">MWLVDGGLKPPSNPNRNRNRNRNCNRSGNRIGNCNRNCNRNRSGNGNRSGNGNGNRNRNRNRNRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E2</accession>
    <name>E8X4E2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1206"/>
    <dbReference type="EnsemblBacteria" id="ADW68269">
        <property type="protein sequence ID" value="ADW68269"/>
        <property type="gene ID" value="AciX9_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1206"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573377_0_0_0"/>
    <dbReference type="OMA" id="INHWISS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="475" mass="48783" checksum="B53869533441142B" modified="2011-04-05" version="1">MSQGDTLSRSNISPARSSSRWTAELIRTTRNTALIAGMIASTGALLAQAPNVSDAQVESNVLKALAGAPELASEAITTRTVYGTVTLSGTVATEPLRKRAENLAANAPGVKKVVDQLTLGGASVSANQSAGPGPNMVLQSDGSYAPADSTQPDTAQNAPPPTSPNGQYQRNNPDADQALDQQAANQQPQQTPAQTNDPANRRPLSASNYPPSPQGGNYPPQAGQPYPQQQPQGYPPQYQQYPPVQPGYSAHGYAAPMDGGQVAGQPVTVPAGTLIRIRVNQTLSSQHSQPGSNFDGIIINDVVAGGLIAIPRGATVRGTVVDAKPSGALNGRGEMTLQLNQIILAGKTYPIVSDDWIHNGGDKTIESVNKTLGFGAVGALIGAVAGGGVGAAVGGGVGAAAGLGSSAASGRGQVFVPSEAVVTFHLAQPAPILTVSEQEMQRLAYGVAPGADPRYARRAYPRPYAPYPAPYPPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F8</accession>
    <name>E8X4F8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1222</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579608.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1222"/>
    <dbReference type="EnsemblBacteria" id="ADW68285">
        <property type="protein sequence ID" value="ADW68285"/>
        <property type="gene ID" value="AciX9_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1222"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_0"/>
    <dbReference type="OMA" id="ANGYHIV"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="199" mass="21505" checksum="03DB99AA7D44AF74" modified="2011-04-05" version="1">MSETALVLPEGEFKAFLFDMDGTVADSMPIHYLAWVKAVTEQGGTFPEDVFYAWGGIPPARVAAMLNEKYGYSLDATEVTRRKEELYFESLPTIKPIASVVAHIEASRGKIRFAIVSGSPRESIEKTLTFLGLLDSFEVLVGAEDYAKGKPDAEPFLRAAELLGIAPKDCLVFEDADAGIASAEAAGMSWVRVPGPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R8</accession>
    <name>E8X4R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581868.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3553"/>
    <dbReference type="EnsemblBacteria" id="ADW70557">
        <property type="protein sequence ID" value="ADW70557"/>
        <property type="gene ID" value="AciX9_3553"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3553"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="PYWHQRQ"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="38411" checksum="BC93B717EF997E3B" modified="2011-04-05" version="1">MEYRLLGRSGLKVPELTFGAGTFGAGNEFFKAWGETTQEEADRIVSICMEAGLNFFDTADVYSDGASELMLGKALKHHSRADLLISTKTTFRQGRHKGPNEVGSSRYHIIEAIDASLHRLDTDYIDVYHLHAFDALTPVEETLSALDNLVKSGKVRYIACSNFSGWHLMKSLSVSERYGWSKYVGHQVYYSLIGRDYESELMPLAIDQGVGALVWSPLGWGRLTGKIRRGQPLPEGSRLHKAADGGPQMPDEYLYQVVDALDEVAKETGKTVPQIALNWLLRRPSVSTLIIGARNEEQLKANLGSVGWKLTPDQIAKLDAASDPILAYPYWHQRQFEERNPKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S9</accession>
    <name>E8X4S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3564</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581879.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3564"/>
    <dbReference type="EnsemblBacteria" id="ADW70568">
        <property type="protein sequence ID" value="ADW70568"/>
        <property type="gene ID" value="AciX9_3564"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3564"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="THHPGRK"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012700">
        <property type="entry name" value="CP_lyase_PhnK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037116">
        <property type="entry name" value="CP_lyase_PhnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="29712" checksum="DACF4A10D42787CA" modified="2011-04-05" version="1">MTVTEPLLDVRDLTIAFGGKPVVHSISLSIAPGETLGLVGESGSGKSATSFALMRLLPPSATITGSIRLEGHPILTLPEPQMRTLRGSAVSMIFQEPMTALNPVMRIGDQIGESLLAHHPRTPRAELRARVIAAMQEVGLPNPEQRLRDYPYQFSGGQRQRILIASALINRPRLLIADEPTTALDVTVQAQILDLLRKLRRTHNLSILFISHDLAVISQIADRVAVMQHGRIVETAATADLFRDPQHPYTRKLLASAPTMQTDRSKPLATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W5</accession>
    <name>E8X4W5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3601</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581915.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3601"/>
    <dbReference type="EnsemblBacteria" id="ADW70604">
        <property type="protein sequence ID" value="ADW70604"/>
        <property type="gene ID" value="AciX9_3601"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3601"/>
    <dbReference type="eggNOG" id="ENOG5033EKQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076728_0_0_0"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230230" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27937" checksum="76616EFDEA3AD0ED" modified="2011-04-05" version="1">MKSTLVLFASLIALSAATSGAQTAATCRTLAPDAQDALTASPENHTVLYENADVRVLDVHSQPHTREAVHTHSMPSVMYVDRQGAGTYNTPDGSGNKSHPTDPNFKFRIFAIPSEGQHWTENTGEVPFHAVRVEFKHPGCGLPGWRPASPGPDDALVAAPANYTLLLENQNVRVLDLHLAPHATTSFHTNPWPGFFYVIQGVSMRDETKAGSQPEPRNLPTGVKILPAKAGGHTIENTSDTPLHLIRYELKFSSPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X509</accession>
    <name>E8X509_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0124</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578529.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0124"/>
    <dbReference type="EnsemblBacteria" id="ADW67201">
        <property type="protein sequence ID" value="ADW67201"/>
        <property type="gene ID" value="AciX9_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0124"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_14_1_0"/>
    <dbReference type="OMA" id="DAWWFMF"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45269" checksum="8C0A83DFE5BE11E7" modified="2011-04-05" version="1">MASYKIFMKSGHPPTLLAAFLYFDFSFAIWVLNGVMGPFITEQFHLTPIQTGTMISVPILAGALMRFPLGVLSQYIGRKMAAIIEMSCIVLALLYGYFFVHTFHSVLAMGVLLGIAGGSFGIALSLGSGWFPQQYKGLAMGIAGAGNSGTAFAALFAPKLAMHFGWQHVYGFAAGCMMLPLLVMIFFAKEPPDVEHQSLSQHLQCLWQPDGWYFNMVYIITFGGFIGLSTFLTTFYVSQFHMTKVQAGLYTVLATFTGSATRVLGGYFADKIGGITTLSVVFLIAIAGLFGLMTTPSLLVTTLLFMLCFAALGAGNGATFQLVPLRWPTTTAIAGGMIGEIGALGGSLIPTILSYSKQHFGSYRNGWIMYAGLALLVLVVLRIVSRSWTKTWVGPGGRALTSSRVIDGPVMVSAEGATFAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X519</accession>
    <name>E8X519_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0135</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0135"/>
    <dbReference type="EnsemblBacteria" id="ADW67211">
        <property type="protein sequence ID" value="ADW67211"/>
        <property type="gene ID" value="AciX9_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0135"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_0_0"/>
    <dbReference type="OMA" id="KSFAFWP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26995" checksum="146A43D8E779CCE0" modified="2011-04-05" version="1">MIIRMLPRPERSIFESLAQLDVLSKRDTILAAASRVFIQHGYEGTSMELVAQTAGSARRTLYNQFPEGKAQLFHAVVERMWMAFPVMSIDTDEAMLADPAKGLRTIGYAIGEFWRSPLAVSFLRMIIGEASRFPELMRSFFDAGKTPAVGAIRNYIAELGKRGVLKLTDAELASQQFIGMVDESLLWVRVMGSEAELSSARITEVVEQAVVIFLGHYLRGKLSTKSPKARRAKSALGIRSRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X542</accession>
    <name>E8X542_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">40-residue YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1243</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1243"/>
    <dbReference type="EnsemblBacteria" id="ADW68306">
        <property type="protein sequence ID" value="ADW68306"/>
        <property type="gene ID" value="AciX9_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1243"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721165_0_0_0"/>
    <dbReference type="OMA" id="YVASCGP"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="441" mass="45911" checksum="8EE447F0AF7ABB85" modified="2011-04-05" version="1">MPGSTPRYNPVSYRDHSQNNPQPYTSPSHPPHPSTKLTKVFSSPQSLRGILLAAALLPLAACKHYNMPDYPAGYREFAYVANSTGNTVTVLDLVYLRPDRTLKVGADPTAIAVNPKLDEAYALNTQPSDSTGSVSVIDTDKNEVVATIPVHRTPSALAISPDGLRAYVTNQGSNTVSVLDLKTRRAIASAPTGDQPAGIAIAPDNRSVVVTNQASGSVSIYAIGIQKASPLTLRATFPGCPGATSPVIMPDSAKTFVACSTGHQIMAIGLSMAPDSWALKQDASLNTDRLLALLVVGQHPTHITMKPDGGEVFVSNQASDSISEVSTQTNDVGSTYAIGDRPTHGVVSADNSALWVAASGNDSVSLYSIDDGKFLSSLRTGSTPDALAFSADQHLILAADSHSGDVAVIRTATKLGPALLTILPAGGTPVALAVKATQTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X544</accession>
    <name>E8X544_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1246</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579631.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1246"/>
    <dbReference type="EnsemblBacteria" id="ADW68308">
        <property type="protein sequence ID" value="ADW68308"/>
        <property type="gene ID" value="AciX9_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1246"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066538_2_1_0"/>
    <dbReference type="OMA" id="FHVPMWF"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="271" mass="30076" checksum="EFF50E2E1746C529" modified="2011-04-05" version="1">MAQSTQPSSSRTFTPVQQPASPAKLLLGALWLAATLIVLAIGFRQAIFIAPTEATMGDVQRIFYWHVPSALLGLIFPYVNFAASIAFLYLRRRNPLSALTADAIAVAAAEVTVIFTTICLATGMLWGKASWGIWWAWDARLTSLLLLWLLYVAYLMTRRLSATGQTGTIGAVISVFAAIDVPIVYFSIQWWRTQHPSPVLTGEGHMAAPMWIAFGWNAVGWLMWGIFILVLRFALERRRQRLDQEHTLRSLEATLTPADGLTYGQEPNHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5A6</accession>
    <name>E8X5A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579693.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68370">
        <property type="protein sequence ID" value="ADW68370"/>
        <property type="gene ID" value="AciX9_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1308"/>
    <dbReference type="eggNOG" id="ENOG50349JF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281698_0_0_0"/>
    <dbReference type="OrthoDB" id="2028182at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="215" mass="24654" checksum="C4F72769E09F16FA" modified="2011-04-05" version="1">MARRILVLILIVILVVSCYYAWKNYEHRQRMDDGNVSCTGCLSPEQESAFKRENAGETADGQSEHKFDFRGTEQDRHNGENGRRFDDGGGQPVPDNDPNQRFRIPERDGGYADDRGHDRADDRGFDHANDHRFDDQQRRFDDPGRRSDRPDFGRDTLQPIPPNGAAFAGRGEYQWYREGNLTWRLNTETGASCVAYATLEEWRKPLVFTHGCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5C5</accession>
    <name>E8X5C5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ordered locus">AciX9_2437</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580788.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2437"/>
    <dbReference type="EnsemblBacteria" id="ADW69472">
        <property type="protein sequence ID" value="ADW69472"/>
        <property type="gene ID" value="AciX9_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2437"/>
    <dbReference type="eggNOG" id="COG2156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077094_2_0_0"/>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="OrthoDB" id="1912405at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="20638" checksum="193FDE0DF5990DDE" modified="2011-04-05" version="1">MRRNLLIALRFTIVTTFLFGLVYPAVVTGAAQLFFKDKADGQLIHRNGVLVGSRILGQSFSGPTYFHSRPSAAGSGYDAANSSGSNLGPSSKKLLDRISADASAAQAGQPDATVPIDLVTASASGLDPHITPAAADFQLARVAKERHIDEAIVKQAVARQLEGRQFGFLGEPRVNVLELNLNLDEITANSTQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5L3</accession>
    <name>E8X5L3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3637</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581951.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3637"/>
    <dbReference type="EnsemblBacteria" id="ADW70640">
        <property type="protein sequence ID" value="ADW70640"/>
        <property type="gene ID" value="AciX9_3637"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3637"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642161_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234212" evidence="1">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="427" mass="47198" checksum="4F0E85E47C108327" modified="2011-04-05" version="1">MIARHTLVLLMLSASIPTYAQFQQQQSDTISADKALDEALKHSSLTEGKAPFHAVLEISGPSPAYSGGIDLLWAAKDQYRIKIDSPAFHQLRILNGTQVSEKDEGNYYPRWLENFVDALLDPIPMAANFKGRNGAVSVGSFVTNSCIRRDDRPGGITDQLTWGMICFSGSEPRLASTLTTNSSLDFSDFKSFGKQQIAHTYTTDVLDYKPVTGRLTVLEKLKGVDASQFAIPSPTPASERIKTTFVSTLKEESLVDDPPTLNWPSVHEGKTEGYMIVYARTDRTGQVRETSKHNSDNPGLEQFGMEQALRYKFHPLIIDGVPQQMEMPLVLHFVSRVENPLPNLNDAQTRAQITGCEIPHAETGQPSYLESVSVNEQGKLTGEGFPDANKPGFVSPTQFLDLESCHFAPHLVNGQPTYYHGLLTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M6</accession>
    <name>E8X5M6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3650"/>
    <dbReference type="EnsemblBacteria" id="ADW70653">
        <property type="protein sequence ID" value="ADW70653"/>
        <property type="gene ID" value="AciX9_3650"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3650"/>
    <dbReference type="eggNOG" id="ENOG5033J8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2371770_0_0_0"/>
    <dbReference type="OMA" id="CGHEYGE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9785" checksum="3C5B302027734D64" modified="2011-04-05" version="1">MVRKIRMPQSAATTRPGYRNDHGQVVVRDTGWGSESFPGQRVYHLRCEHCGFEYGANGTDIAKRLCPSHQGGVKGERLREVGPRLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P2</accession>
    <name>E8X5P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3668</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581978.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3668"/>
    <dbReference type="EnsemblBacteria" id="ADW70669">
        <property type="protein sequence ID" value="ADW70669"/>
        <property type="gene ID" value="AciX9_3668"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3668"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595706_0_0_0"/>
    <dbReference type="OMA" id="GWHDRIS"/>
    <dbReference type="OrthoDB" id="1483147at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="321"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="49206" checksum="5CEE21C849FD95A1" modified="2011-04-05" version="1">MSSAQLEISPADETAAALAGQHSESPRPGALRQQMAERIAQHRQRRSYHGHSAVQLFEDSKPEGRNKIAATVAERYAQSPSYRAFLADEAQKAIRQAAAAAEVAVRSAEAVATAQKELLAELELWTAPQEFTAETAVMVEPAKAEPTPVPTPEPVRQISSAGITVKLYEDVGRAAILSAPAKLSVAPFKSLPAPPLDDEEYLALDEEIAFRKEPVFDDFRDFSAPVEPIAANLLSFPRQLIATKKARPRLAEGPLRDEPASRAPQLRIFEVEAEQISPEPPPSSAPEWSSIHLDAHSVIEPFQAPDDDTAIMPTLLPPHTAAVSQRLMAAAVDFTLVSATFLAFAATAAYVAGSVPTGAAAATTSAVVFAILYLSYQLLFFTFSDQTPGMRYARIGLCTFTDENPSRSAMRKRILATVVAACPFAIGLLWVWLDDDRLGWHDRISRMYQRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q6</accession>
    <name>E8X5Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3994</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70790">
        <property type="protein sequence ID" value="ADW70790"/>
        <property type="gene ID" value="AciX9_3994"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3994"/>
    <dbReference type="HOGENOM" id="CLU_228085_0_0_0"/>
    <dbReference type="OMA" id="CTINIAA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234421" evidence="2">
        <location>
            <begin position="29"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2471"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2563" mass="257250" checksum="7420196787EE7C16" modified="2011-04-05" version="1">MASLRNTLLISSLSAFLPFVTASLSAQAPKPLVSGHKQLDRTLPLAFEENAGQLAAGVGFLGRTQHYSVAIGSKDLRFSLPGAHKSSSVVMTFDGSSATAPVGITTAPLLTNYYMGKDPSDFKTGIRNYSRIGLNHVYPGIDAQFYASGEAIEHDFLVSPGADASAISMHLSGADKATLDAQGEVLIPAESGELRLKKPVAYQITPEGKHVEVAADFVLGGDASSRSLRFALGDYDHSRQLVIDPVIVYATYFSGSADSTATAIVANPAGDVFLTGYTRSPAADFGVTATTDNSGGETTGIAYFVARFNNTDKGSKVSWLTYVGVDAVDSKTTALALQPTPAGVVVVVGGTTAPVTTPAVTPTPTTGFLSFLKSADGTFNSTMPFAAATGGVADTGISAVTAVASDSLGNVIAVGNSTGSALATTTDAIVVDAPTLAVPVTKGVIVKLNATNTVTFASYLMGDTLNPFTTISSAAADPAGVSIYVGGYTVGDFPQAGTYSSGAMNQPNAGEPAGAYNSFAAQILPTGTATQATIGYSVWMAGSGSDQLNSIALDTSTKSSIGNLLIFGQTTSTDLPGANVTYTYFNTDTPVTTPTQGQVGATPVSGTLTKSATTNNSGFVVSVDQTGKPLVVTYLGGSGDDVINAGGVDTNGMVYAGGSSTSSQTMSYPPAVALGGPTTPVLPAGQDNTLVSSKHGFVIQLPAALSAVNYIANVGSPSGPDTGIGLALDSSNNAYLAANIAASLFPAYTPPGANSAFEKSAKTPAIASAYVAEIANSAPSQLTLTAIPLSDATVVSPLAPPTPVTGTPDPIGYAGTNVAVQYLWQLTDSSTALLTPLDIIVQIPATTGLTYSAPTITDVNDPTKNVGATCTLLASGDAYCTFLAFPQTTSGTNDTLLVTLPAMLTAQPTSSLILTATAVDAGSDTTSSSEQSNIQVPASFTITAQATVPAAGYAFTTNTGGSLPSTQVSYAFTISNTAPIGGDATGAIFKLNPALTNQFQIVSATLSPGAIGTCDTNGCTGLTITAGGSAIYTITGYIPDSELAGAASAISSDSFTPHVSSTLSTPGDLSYAPKTPIERGVHLVLGSSLSPSSTAINLGDSIAYTVTVGNNGPSATSGTDVLTVTLPTGFTPTSTGSFVCGNGTPVVCTINIAAIASGGSASPAYTISGKFLDNQNNAGILAAAVAEKFSATATLNGDFESTATAGGPDYATSASTTVQRTAVLSILNLGASLPQLDTTCAGGNGHCIYLSKTGDGSDTINYTFAVQNQGPNIAVGAQFTINLPSAPTNASGAHPLVFTVGNTTASATPLFGSKVTCSAPNASNQILCSGNIAFDPTIGTPTTVTIMGTAASDATSVPANAVFVTTAATLGSFGLSESANGAPAGNSALPLIEIDRAAHLVTTKVISLVGSTPSSPINLEENKASLLPGVNDTIKATISVGNSPLDDAPSVVLTDTLPAYFRMTQLQIPAGVTCTINGTAVTSPLTTGYVTGPVATPAVLTCALGTVAAKTATARVGSTPATITTPAVTITYSGKFIDNGASDDITGLAATKQAMAAVTLAGAASTTSFAVDPSASDATSQGASVNVVRSAHLLVRKTRNSAVAVSPFVDKDPNLDEKKAAFGVNDEIEYAVTLANGGVNTAVGVQFADILPPYFTVLKTYFVAGSSVAPDNAANLGPTTAAVPGLTCTKADGSALTLPIVTQGTSLPIICTYGTATAPIALAAGASKTGAFESTSSVQFVYQGKFQDNAPGLDNLGNGVSTYSVTSAPGDATVSSAKVVDPGPATDSKSAALAAYTIQRAAHLILMGAPRQTMTNETPLTAGANGPIIAEAEPSVGGGTPVFNCLRYKVYVQNSGPNISRLPTFTVVPPAGLNLASSAMGTTTTPGSDTPLPSTCSYGATTSTTISPTSVVTPLSELPGSALVIDVDGYFKLGTLAGVNSQLLPATLAYSALMDPGIVDTTGATFTPVSGPAVTVVNTPSGSNFIVAPFSSTGTQPATLTFAAVAAPGITTETTTNSFAARPMGISPDPRGSKTAIPLYQAGSAAPNFYTLGTTAALVNSGNPTNLCFANPAGGALSDGFAKPERVLLWPLAGYTSTNFIHTVPNIPAPAGDITTLVKPLTGTSYVEAGGSALPYTSFAGFPATQSQPAMVCGQVDGFAPVTAPLTVAVLEPVNFAPYQTPNSASISSTPGKGVSEVSFLFPTAHDYNEHDPCYTDSSTSGVGTNRGTCDDNKVLTTWIFGGEALIPSQSHVVGPLATAAGSAFVNSTVPYEVQGGETLFELVADQLAVAVYKAANFCDPGNAPGSYSPVTVPAPCPISIAGLSSNPPQEIVFSSADISDLTPSISGGGSGLIILPPATTPSSPSTTVLTGYTAAAATVTAGQTVGFQWKLGDIVPTATGGTYTLSCFGVDSATQSIVTPLPAGLTCQIGGTITFPANFTTATAPTNPAIYVVTSGTLNAQNRVPATLPTWKLVGGGVLAAMLIPFAVMRRRYPKRFGLLVLLLMLTGAAGLSGCGSGGIAGTTATTVTPAGSYYFRASATPATGSGILYSTAFSVKVVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R7</accession>
    <name>E8X5R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion protein, VC_A0107 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572713.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70801">
        <property type="protein sequence ID" value="ADW70801"/>
        <property type="gene ID" value="AciX9_4005"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4005"/>
    <dbReference type="HOGENOM" id="CLU_111033_0_0_0"/>
    <dbReference type="OMA" id="MTFESME"/>
    <dbReference type="OrthoDB" id="1278805at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35850">
        <property type="entry name" value="PTHR35850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028301">
        <property type="entry name" value="UCP028301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03358">
        <property type="entry name" value="VI_chp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19312" checksum="84C6EABDAF7B3EB8" modified="2011-04-05" version="1">MAESTQHKLDRVRSPRVHITYDVEVGNAIELKELPFVMGVLGDLTGQPETPLAALKDRKFVEINPDNFDTVLKGMQPHLAYSVDNKLSDDPNAGQVKVNLHFESMDDFSPENVAKQVKPLKELLDLRTRLSDLRGTLQGNDKLDQMLFDAVSNTEDRNKLRAEVGTTPEGGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X621</accession>
    <name>E8X621_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4125</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572817.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70905">
        <property type="protein sequence ID" value="ADW70905"/>
        <property type="gene ID" value="AciX9_4125"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4125"/>
    <dbReference type="HOGENOM" id="CLU_1308671_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230771" evidence="2">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="22621" checksum="A8B98F4D20AA55C2" modified="2011-04-05" version="1">MKLGKSNLYLCRLLCAALAATNAVWAAAQKVDIRFPLTPDQIIAAMQVRQLPVEGVKVILSAPITAAVSAPVLEIQTIALVNNHTAQLKMSCRDHRECLPFYVNAVWPETSPNLVLPASVKQEGRSKQPNLLLSSGAPASDSSTRSSAPTTLRVGSAAMLMMDHDRVHVRLRVVCLDGGITGDKVRVTTPDRKQAYVAEIVTPTLLKGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B4</accession>
    <name>E8X6B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70998">
        <property type="protein sequence ID" value="ADW70998"/>
        <property type="gene ID" value="AciX9_4220"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4220"/>
    <dbReference type="HOGENOM" id="CLU_857328_0_0_0"/>
    <dbReference type="OMA" id="LANICMR"/>
    <dbReference type="OrthoDB" id="1358757at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="373" mass="40013" checksum="9DBF2574B5A0A097" modified="2011-04-05" version="1">MGYVTIEKMKWVLVGLLCIRGGFGVLAQSTDSKGLQVRPAAAAQGASATTAEAETLRGLRKQIDTGHADEALQRIVSLRTAGPGAAGYRMAGLSRMEGLALFAQGKLREADTAFADALVEDKGDVESAQMRGLTLFRLGRPADAIPLLEGSKGKANGGDRKADPNYVLALCYIDTRKYDDARHAFAAQFGMEPDGAGAYLLAARMLLRREYLPVAQGFAEKALALQPGLPLAHALLGEIALAGNHLEEAIAQFEKEKISNPLEPSVYDRLGDAYGRAARYTDAQASLQEAVLLEPNSTGPYILLGKTMLKQGDALGATTYLERAVKMDPANYMTHSLLGQAYRTMGRTEDASRETSTAQKLQTASEPKLENLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6J5</accession>
    <name>E8X6J5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3862</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582166.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71145">
        <property type="protein sequence ID" value="ADW71145"/>
        <property type="gene ID" value="AciX9_3862"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3862"/>
    <dbReference type="HOGENOM" id="CLU_051175_1_0_0"/>
    <dbReference type="OMA" id="LWAFVVE"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="401" mass="43932" checksum="A69B44E345CEB9E8" modified="2011-04-05" version="1">MNATQQAEDDVATVPDIRTALSLAEAAEAQPILIELIQMLIVNRRFFGKMSLAGVLCGIAIAFLMKPVYTATATIMPPQAAQSSLSSLMGQLGSLSALSGGASSLLKNPADMYVGILQSRTISDTAIEQFHLKERWHEKTMVAARKAVASHAQFESSKDSLIQISVKEHDPKLASDLANFFVDALYRMNSTLAISEASQRRLFFEKQLDEERGALAKAEDTLKATQQKTGLITVTGQTELAIRNIAQTRAEISARQVELQSLRTYASEDNPDVARVQGEIRTLQGQLSRLEDSESHLAPGDTEIATSQIPAGGLEYTRELREVRYHDTLFDLLSRQYEAARIDEAKSAPIIQVVDRAVPPDQKSGPPRTLIILGCTVLAFLVGFAWLFLRGHVAMLRAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K5</accession>
    <name>E8X6K5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3873</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582175.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71155">
        <property type="protein sequence ID" value="ADW71155"/>
        <property type="gene ID" value="AciX9_3873"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3873"/>
    <dbReference type="HOGENOM" id="CLU_1281699_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="215" mass="24254" checksum="4A0B090530934FD3" modified="2011-04-05" version="1">MLVPLPAPPTQLTKVKTEVSFNAEDPWNGNRRGIFLLENYLTTLRNFVPNEAQAARHQGEFHRALRSETDGVTRFLPESLIELWLTNKVPTEALPNLLSQIEPTLRKSDYILMMRRKAMKVFAVFETICCSALVLLAVAVVVGCHAPIWIAVLLVLATASVCWGFLYLTYFGKLFRRKRQMKWLLDRVHTSIPSPTVFPDLPGAANCTVVDPYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L1</accession>
    <name>E8X6L1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582180.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71161">
        <property type="protein sequence ID" value="ADW71161"/>
        <property type="gene ID" value="AciX9_3880"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3880"/>
    <dbReference type="HOGENOM" id="CLU_1209319_0_0_0"/>
    <dbReference type="OrthoDB" id="2128105at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230801" evidence="1">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="25253" checksum="0C7879FDB2D4C744" modified="2011-04-05" version="1">MKQLLRTTAITLVALGASASAANAQFYKDVFKPHGASISVGGTGLFSTPLESNPTSGTFNVPRVGGGTLSETVSNQHQDTTWSAGFITSLQFHPKPWAGLELNYGFSRFSEVYSYNYSSTPTVQSSKVTTDMHEYTAAYQFHPKHILFQPFVNVGGGYVEFIPGTASSQFRETGLLEAGFDIPTHTKHIGFRIEGRSLYYRAPNFENSAISTRSWRVTTEPSISTYYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L3</accession>
    <name>E8X6L3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582182.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71163">
        <property type="protein sequence ID" value="ADW71163"/>
        <property type="gene ID" value="AciX9_3882"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3882"/>
    <dbReference type="HOGENOM" id="CLU_056689_1_0_0"/>
    <dbReference type="OrthoDB" id="1564715at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="30672" checksum="125E71B2E419A644" modified="2011-04-05" version="1">MSRYNLKSLLCPTETVNVEQLETDRRILAFDRTIQHLNRRGFLGAMLSAAAIGMVAGEREAHAQTATPAITDVLNFALNLEYLEANFYLYVTTGAGLSSSLNGGGLAVQGAPPKIALTANTMAVAQALANDEVNHIADLRSAITSLGGMPIAQPLINLSANGAVTTQAQFLAAARQFTALGGSAYVGSAQLLVSNPSVLTTAGQILGAEGQHAGALAYLCVTQNVVSPAIDAQDIPPTATNYFTVDAVNALSPARNTSQVLGVAYGKSTATTTTPTTGVTMGGFFPNGVNGNVKSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N9</accession>
    <name>E8X6N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3913</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582207.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71189">
        <property type="protein sequence ID" value="ADW71189"/>
        <property type="gene ID" value="AciX9_3913"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3913"/>
    <dbReference type="HOGENOM" id="CLU_018816_14_4_0"/>
    <dbReference type="OMA" id="RPGMNAV"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="224"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="44929" checksum="84B2E20BC8F3D1A7" modified="2011-04-05" version="1">MTPNQASGSRALILVALLLTAGGCKKTAPADDADKPVITVQAVHPTEGPITEDILADAILAPQAQAALQARITAPVKAFYVQRGAKVKAGQVLATLENQDLAAAALDNKGTYTAAQGTYTTATRQQVPQEETQARLDLEQARSTLALDQSILDARTQLFTQGAIPGRDVDTARSTVIQAKAAFDIAQQKFESIKSVGKTASLETAEGQLTSAKGKYLGAEAQLSYTSIRTPISGIVTERPLFAGETAAAGTAIITVMDTSVLLAKLHLAQRQAQQLALGAEAEIAIPGQDEPVKAKVSLISPALDPGSTTVEVWLKVANSDGKLKAGTAVHATIQGRTIPKALTIPADAVQRSAETGGKMVMIIATDGTAHKRNVTVGIATAETAQITSGLTPSDTVITTGGYGLDDGTKVKVGPAEDKDKADAADAKPAAGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U1</accession>
    <name>E8X6U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid encoded RepA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3965</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71241">
        <property type="protein sequence ID" value="ADW71241"/>
        <property type="gene ID" value="AciX9_3965"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3965"/>
    <dbReference type="HOGENOM" id="CLU_051492_1_0_0"/>
    <dbReference type="OMA" id="VEGREFM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006881">
        <property type="entry name" value="RepA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04796">
        <property type="entry name" value="RepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="37988" checksum="D3FC838B58A8936E" modified="2011-04-05" version="1">MSSETEAVDGSAGMDEVEGLSPVAMRLLQAATDMQQSPDSYERAFLARQLIQCTFPHSDPGNIPIWSRTNGNLTLSIRPLYDEEKAAHKYPYGTIPRLFLYWMVTEAARTKKRRLYLGQTYPDFMRKLGLNPSNGGVRSDSRRLKDQIERMLRATISFKQTFKKDGKTGDAWLDMQIGPEAVLWWNFDKDAQNSLFESYIELSEKFFSAITSSPIPLDLRALRALRKSPLSLDLYSLICHKTYSARKDGDTKTIPWEGLHRQMGAEYKELRNFKQKVVATVKKIRLVYPQMKVDLSESGMHIHPAPLAIPERVGSEFAAPTIEAPLAKRRRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W5</accession>
    <name>E8X6W5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3991</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71265">
        <property type="protein sequence ID" value="ADW71265"/>
        <property type="gene ID" value="AciX9_3991"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3991"/>
    <dbReference type="HOGENOM" id="CLU_016031_8_3_0"/>
    <dbReference type="OMA" id="SHADTHY"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="5">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="482" mass="51298" checksum="984F2163BBAFCEC3" modified="2011-04-05" version="1">MQGLVALPLTAVLPASVYAQTGRKKAVAPAPTQKPKSDVQVNVRDLGATGDGSTKDTVAMQLALDRCSVLGGGEVLVPAGEYLTGALRIHSNTVLRIEEGASLNGSPDIGDYPFTQVRWEGRWIKGYSAFISAQDGENVTIIGKGKIVASPAIKGRVVHADGSPMVYTRPAAGTAPNPDGPTNVARRDIMRNPALMEFTHCRNVLVQDVFTQGNDMWSTHPVYCENVTFRNVTVHSGADGIDVDSCKGVVIDGCEFVTRDDCISLKSGRGMEGNTIGVVCEDIHISNCTFNDAVWACIGIGSETSGGIRNVHVEHCKCLGARTFAIYIKSRPGRGAFIEDIYMNDLEVSGAQQGFLRFNILNSGLQDPDPVPGDDGIPTIRNFHFSNIRVKDVPVLVDGASIHPRKPLEGFSLTNVTGTCGKGIRLANIHHAVIHDVKVTGFAGPLLSTRNVTGTGLGGAVPLQEEKVPDAIGPPVKAYVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X700</accession>
    <name>E8X700_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3823</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582131.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71109">
        <property type="protein sequence ID" value="ADW71109"/>
        <property type="gene ID" value="AciX9_3823"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3823"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_3_0"/>
    <dbReference type="OMA" id="SFVVDFH"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="28668" checksum="1F6A076523C43167" modified="2011-04-05" version="1">MKRREATAALTPMQAKIRPVTKVSISEDIAQQIMDLISNGDLKPGQRLPAERDLCKNFNAGRSSLREALRCLSIMGVLDARVGEGTTVAVDGVKFMGKIVEWRLITERHDIEDLLEVRMALEGIAVAKVASLGREEDLQRLQKSIKEMRGAIKDAKRFAALDLAFHVAIAGMSENFLLSDLISMIRSQLVRGLSAVLLLPNAVKLSLEEHVAIYEAIKAKDAEGARAAMQGHLQAALERYNKSVARQERTKSPRSNTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F0</accession>
    <name>E8X7F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573103.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71384">
        <property type="protein sequence ID" value="ADW71384"/>
        <property type="gene ID" value="AciX9_4438"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4438"/>
    <dbReference type="HOGENOM" id="CLU_037612_5_5_0"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="24378" checksum="BED4EDB824D0662D" modified="2011-04-05" version="1">MPVIVAANPKGGSGKSTTCIVLGTTLAAQGASVRIIDADPQRTLGRWGEGSSAFREIVVTPTSGEDLTVLIDRLQSRFQFVFIDVQGTANQEMVAAMSRADLVLIPMQAKTADAEVATRAIGLLRTQENLFKRSIPHAIVFIRTSPIIVTREEKEIRTNIETAGVPRFVASLNERTAFSHIFAYKQSLGELNSKDTNGLQAAQQNAVELTAEMVQLLRKQLVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F2</accession>
    <name>E8X7F2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4440</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573105.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71386">
        <property type="protein sequence ID" value="ADW71386"/>
        <property type="gene ID" value="AciX9_4440"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4440"/>
    <dbReference type="HOGENOM" id="CLU_849322_0_0_0"/>
    <dbReference type="OrthoDB" id="1074108at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="327" mass="36931" checksum="02317C09EEF4E080" modified="2011-04-05" version="1">MSEILVRKPRDYAKERKAAIEASVDRTVALREDRDTGALGDEVIKMAQALILCTLPYRPTAERQVVRSARLSDGSTLRVTFTAGINGIDMAFGNDRHLMAWLFDKAINSDTAFVTIKSASDYLRETGKSRNGDRVKELAARLSRLTGLVIGIERRGAGSTQTVMLPMIASSNLPSNLTVQLRAENSGQRSIPGMENPFGIQLEERFFQDIKKHHVAIPRRLWMQLQGQKGGPQLTDLLTFFVYRCYCAQSETVIPWAGLREQFPQDDSNPRRFKVSVKKAIVQLRVVWPEIRIDIVKEGVWVDRAMQPLLPDDPTKKRIRRLSALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J4</accession>
    <name>E8X7J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YVTN beta-propeller repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4482</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71428">
        <property type="protein sequence ID" value="ADW71428"/>
        <property type="gene ID" value="AciX9_4482"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4482"/>
    <dbReference type="HOGENOM" id="CLU_009318_3_0_0"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="349" mass="37429" checksum="53266951335686D2" modified="2011-04-05" version="1">MSYSYITSNCFEVRQLKAATILGAAFLSISLFLLDKASAQAGTILAINEGESTLSIISPKNGQEIARVAEGGVAGHEVVASFDGKTAYVPIYGDSSAGEPGSDGSEMVAIDLATHKVVGHVDFGHGVRPHQPTLNPHDGMLYVTTELDQTITVIDPKAMKIVGTIPTGQALSHMMVMDHEGRFGYTANIQPGSVSVLDMHERKLLTILPIAAKIQRIAISADDKKIFTTDQMKPRVAVIDTATRQVASWIPLPAIGYTLTTTKDGLWLLIGIQSTSQVAVIDLELSKVVRTIDLPKSPHEILMSPDGTTAYVSCTADEQIAAIRVSDWTVTKLIKVGTRVDGLAWAEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K2</accession>
    <name>E8X7K2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4491</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573155.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4491"/>
    <dbReference type="EnsemblBacteria" id="ADW71436">
        <property type="protein sequence ID" value="ADW71436"/>
        <property type="gene ID" value="AciX9_4491"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4491"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="82" mass="8709" checksum="2E6ED08D5E609A89" modified="2011-04-05" version="1">MSAGQLEAHAILTRIVRALVRNPDAVNIEIRLAHTTTFVVTVAASDVAKVVGKQGATAKALRTFLYAMGAQMKTPFALSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Q0</accession>
    <name>E8X7Q0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573203.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71484">
        <property type="protein sequence ID" value="ADW71484"/>
        <property type="gene ID" value="AciX9_4549"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4549"/>
    <dbReference type="HOGENOM" id="CLU_2167403_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12142" checksum="668A9F1DF6C7774D" modified="2011-04-05" version="1">MATATKTTGSQFDGLLAPRKRPQPEEPEAAPVGTDDTAPTSRVSVAKSKAKSLAKSKNDAYQGRTFYVRKKTYAECDYVLKSNDDPRDMSDLAEELLSTWLINEAKRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV76</accession>
    <name>E8WV76_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0177</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578579.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0177"/>
    <dbReference type="EnsemblBacteria" id="ADW67251">
        <property type="protein sequence ID" value="ADW67251"/>
        <property type="gene ID" value="AciX9_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0177"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028597_0_0_0"/>
    <dbReference type="OMA" id="ANLEVFW"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233892" evidence="5">
        <location>
            <begin position="29"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="529" mass="58173" checksum="155BDD4F68D9EB1A" modified="2011-04-05" version="1">MRSLRRAARLAPMLLSSVLAGSCAVAQSAPDSSTTVRLTVDAHAAATPFPHFWEQTFGSGRAILSLRDSYRIDLDKVHGITGFDSVRFHGILNDDVGLYDPDRKTKNPGLAAQDDPSAGGTVYNFSYIDQIYDGLLAHHVRPFVELSFMPAKMASNPAAIHPFWYHPNTSPPKDYALWDGMITALAQHLIARYGIEEVSHWNFEVWNEPNLDFWSGKPAQESYFKLYDHTARDLKAVSARIRVGGPATAQAAWVGDFLKHCKDNNVPVDFASTHVYANDTAENVMKIKEDVPRDKMVCSAVKMVHDQIVGSPLPKTPLIMSEYNASYANEPAVTDSIYMGPWMATTISQCDGMTESMSYWSFSDVFEEQGVVRTPFYGGFGLMAEDNIPKPAFNVFAMLHGLGTERLKLDSDSAMLTRRADGTLVMALWNYVAPTEPTTSDVAPAGAVRRFTLTLPGGAKQATIMRVDQDHGNVIKAFDAMGKPATPSREQIKQLQQAGQASPAEHVAIRNHQLDLTIPPAGLVVLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV77</accession>
    <name>E8WV77_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578580.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0178"/>
    <dbReference type="EnsemblBacteria" id="ADW67252">
        <property type="protein sequence ID" value="ADW67252"/>
        <property type="gene ID" value="AciX9_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0178"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_0"/>
    <dbReference type="OMA" id="WISRNQA"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="211"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="430" mass="48153" checksum="132D9A588EA0DE19" modified="2011-04-05" version="1">MHERHLHTRREILNGLGASALVAAAPRGLLAAVPAGAHLSKADEAFLAEMIRRGCDFFWDHGHPQTGQVLDRARADGGAETRRMASIASTGFGLSALCIADRYGFYPHAEIVERVRNTMRFHWQKLPQKEGFFYHFSDMETGVTSRGSELSSIDTALLLCGILTCRAYFKDAEIQDLATKIYERVNWPWMLDGGSTPSMGWFEKTGFLAARWNMFAEEMMLYLLAIGSPTHPLTPNYWDNFSRPTVKFEGIEYLSADAPIFIHQYTQAWFDMRGRRDKYADYFENSKKATEAHRRFCISLGGNYSPDYWGITSSDSEHGYTGWGGPPKQGDIDGSVVPAAAAGSLSFMPAECLQTLTSMRAKYGKQAWGRYGFVDAFNPARPWYDADVLGIDLGIGVLAAENLRSGMVWSTFMQNKEMVEAMRLVGFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH3</accession>
    <name>E8WVH3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="6" type="ordered locus">AciX9_1361</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579744.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1361"/>
    <dbReference type="EnsemblBacteria" id="ADW68421">
        <property type="protein sequence ID" value="ADW68421"/>
        <property type="gene ID" value="AciX9_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1361"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952373_0_0_0"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021513">
        <property type="entry name" value="Phage_RSL1_Orf186"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11373">
        <property type="entry name" value="DUF3175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="31451" checksum="4FE3FB53B320B0C6" modified="2011-04-05" version="1">MTPDEQFLREAIAEARAAEQAGEVPVGAVLVLNNEIIARGRNRVILDSDPTAHAEIVALREAGRILGNYRLENCDLYTTLEPCAMCAGAILHARIRRLIYAAADPKAGACGSALDVMNHPRLNHRMEVAVGLLAEECGEMLTSFFRTRRLKNKENAASAIGIEALMTTVKKSAAPKKSAAKTTAKKTAAKPPHKWSAKVTTDSTHPDEGLFNEDAQTIAKKLASKKVSPKGPASGMQMLNFYINRAGKNLPKARQAELEKAKDILSQIIADAKPKAPAKKAGRKTPAKKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI9</accession>
    <name>E8WVI9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1378</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1378"/>
    <dbReference type="EnsemblBacteria" id="ADW68437">
        <property type="protein sequence ID" value="ADW68437"/>
        <property type="gene ID" value="AciX9_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1378"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_0"/>
    <dbReference type="OMA" id="IFGQCDA"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006524119" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="262" mass="27625" checksum="8F5312622AB6F217" modified="2011-04-05" version="1">MIFRTGTTTCFAALLFSSALMAQTPAKPAEPLPDSPTPQAAQPASQLPDAPGAGQGAPAPSPTGPTVIMDTNMGRLTCKFFDKQSPLATENFISLAEGKKDWTDPKTLKKIHGVRFYDGTTFHRVIPGFMIQGGDHAGDGTGDAGYFFDNETTPGLYFDVPGRLAMANAGPNTNGTQFFITELPQPDLDGKYTIFGQCDAHSVLIVATIARVDRNNQDKPITPVLLNKVTIVKEGQAIPAEPVPPAASPAGPGVPVMPPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ7</accession>
    <name>E8WVQ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2559</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69586">
        <property type="protein sequence ID" value="ADW69586"/>
        <property type="gene ID" value="AciX9_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2559"/>
    <dbReference type="HOGENOM" id="CLU_3216874_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="44" mass="5304" checksum="14E713FF394A9F07" modified="2011-04-05" version="1">MIEPFRQNLKGIPKNWKSNLCMRISVPNQHLKYTYSVLRQLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX3</accession>
    <name>E8WVX3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ordered locus">AciX9_3731</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3731"/>
    <dbReference type="EnsemblBacteria" id="ADW70732">
        <property type="protein sequence ID" value="ADW70732"/>
        <property type="gene ID" value="AciX9_3731"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3731"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_0"/>
    <dbReference type="OMA" id="PYIAYND"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="52"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="230" mass="25145" checksum="0D977DE6F7C854F6" modified="2011-04-05" version="1">MARISVFLAAVLIVGIFFLGYKRMTIASAATTQPIAAPALDDHLAPQPGKEKAVFAGGCFWGTQSVFQRVKGVTHTEAGYAGGSQSTATYDQVTTETTGHAESVEITFDPSKITYGTLLRIFFSVAHDPTTLNRQGPDVGTSYRSAIFYESEQQHKIAQAYIAQLDAAHAFHGKIVTDLTPLKGFYNAEDYHQDYATKNPNNPYIQICDVPKTKALAAQFPELFQTYKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVY5</accession>
    <name>E8WVY5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name evidence="2" type="ordered locus">AciX9_3744</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582052.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3744"/>
    <dbReference type="EnsemblBacteria" id="ADW70744">
        <property type="protein sequence ID" value="ADW70744"/>
        <property type="gene ID" value="AciX9_3744"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3744"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_1_0_0"/>
    <dbReference type="OMA" id="GPADGWS"/>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16605" checksum="7587C20D9940ADF9" modified="2011-04-05" version="1">MTELTLSAIVSKRSRAKSDEFQALTDRYLARAAHYMPAQALNFESEDALSAWIAKAPGRAAAHAILFDPRGKTLTSDEFAHTLGRLRDDGAQRIVFAIGPADGWSDQARTRAAALVSFGRITLPHELARVVAAEQIYRALTILAGHPYHLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW87</accession>
    <name>E8WW87_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1412</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579792.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1412"/>
    <dbReference type="EnsemblBacteria" id="ADW68470">
        <property type="protein sequence ID" value="ADW68470"/>
        <property type="gene ID" value="AciX9_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1412"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138598_0_0_0"/>
    <dbReference type="OMA" id="TDCPDEI"/>
    <dbReference type="OrthoDB" id="1809227at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="14502" checksum="5DE7D8CE283D7CFE" modified="2011-04-05" version="1">MTPPLDLPHEKKTILHICQREMLRPLRDQILKLSGFEVQSTCSADEALSMFWASQFDLVLIDVEGQTAVHDAERLCSEIKTAQHEQLVAYVCNWRVAIHTDCPDEILRTEFDPEAFVGGVRKTLEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB3</accession>
    <name>E8WWB3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1442"/>
    <dbReference type="EnsemblBacteria" id="ADW68496">
        <property type="protein sequence ID" value="ADW68496"/>
        <property type="gene ID" value="AciX9_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1442"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051806_4_1_0"/>
    <dbReference type="OMA" id="IHENIIT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="33832" checksum="936DBA427A541703" modified="2011-04-05" version="1">MKRAGSGHALSLLYLNDLKSPRIWGTLAIVVAAYFIAGPIELFIFHSLTHAFNLRSGSPNTLIKSRYGTLMLVRLLLNSVLWVAVCKMLNRSAIAFPLNRRRFLRHTLVGLATGLAVMLATMFSIWGLEAAVVTRSGQTLASACGNGFAWLILDFVGALGEELYGRAIVLVVAERFLGWRGAVLVSGLMFSGFHLDNPGASRIWLFRLFAQGCVLAYATFRSRSIWWSVGYHTGWNWISAPLFGAAGSGYLDEGHLFNFAPHGSIWITGGAVGPEGSIFAFVAVFVALGLLFITTSSIKKQKRADCQIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH6</accession>
    <name>E8WWH6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YicC-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2615</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580955.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2615"/>
    <dbReference type="EnsemblBacteria" id="ADW69640">
        <property type="protein sequence ID" value="ADW69640"/>
        <property type="gene ID" value="AciX9_2615"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2615"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_0_1_0"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="209"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="31938" checksum="84EB9AE2A78BCDFA" modified="2011-04-05" version="1">MSVVASMTGFASVEGTLAGGRGFTLTVKSVNHRHLDLQVRVPMGFDALEAGLRKVVKAGVKRGHVELTVFVEKGSSVGAVQVDEGLLDAYVAAYRKAAERYEEPEEFDLNALLRMPGVMSAAVVPMDVSAAEEAVLEAAQRAVAGLNGVREAEGAALAAELRAGMERLSVMAEEARVLRAGVAAAQVARLRERLAEMLVGVPEDRVVMEAALLVERGDVEEELVRLRTHIERFIGLLDGGGELGRQLDFLLQELNREANTMLSKTGGSAGDAGLRLTELGLAIKVELERAREQVQNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU3</accession>
    <name>E8WWU3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="7">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0349</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578749.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0349"/>
    <dbReference type="EnsemblBacteria" id="ADW67421">
        <property type="protein sequence ID" value="ADW67421"/>
        <property type="gene ID" value="AciX9_0349"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0349"/>
    <dbReference type="eggNOG" id="COG3940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_2_2_0"/>
    <dbReference type="OMA" id="LFQHRMY"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230385" evidence="6">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="38739" checksum="5FF3F431B4DD1CC7" modified="2011-04-05" version="1">MLKSLVLLSALALPCTAFAQTAIQPASSPSATFTNPLLQVGPDPWVTSWKGVYYYTNSSGSNLTLRKTTDITDLRNAENKIVWTPEPGHAWSKELWAPELHRWGNKWYIYFAADAGQNADHRIYVVENPSDDPTQGTWTLKGKVADSTDHWAIDATTFDVNGQHYMVWSGWKGDVDGEQDLYIAHMANPWTIDSPRTLISKPTFPWELHGDLPGRHVNVNEGPEFLRHGNDLFIVHSASGCWTDFYALGLLRARAGDNLLDPAVWSKPDHAFFSTNAAAHAYSPGHNGFFKSPDGKQDWIIYHANPEPGEGCGNHRTPRAQPFTWNPDGTPNFGSPLPIDQPQPKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV6</accession>
    <name>E8WWV6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0362</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0362"/>
    <dbReference type="EnsemblBacteria" id="ADW67434">
        <property type="protein sequence ID" value="ADW67434"/>
        <property type="gene ID" value="AciX9_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0362"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673980_0_0_0"/>
    <dbReference type="OMA" id="CISALMI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230387" evidence="1">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="408" mass="41535" checksum="591439856F58D045" modified="2011-04-05" version="1">MNRVVYGLLRCISALMIVCVAGCGAGAGSSASSGLGLAIVVQPKNQSVPMGLSGSFTVQADDSLGGAGLHYQWSRNGTLIAGATSSSYTTAATAFSDSGSTFTVLVSDASGSVASNAASLTVTARAPKAGDLRFQQVDAASTVNGYVFDDGLLHDVACPLQGGGGTTVTGKSATGTAFYLANDHCSYQFDTFDLPAGTTGLSVGYADVGLPDYQSVLDGTLLPPNSPAPNDPGSVINSLNLDPVNNTVALSFINSDNSSGFDRATYTLPASGLQAAATQEGLKGRVVTAISYDGSQATFLSYGWKGDPSTVYEAKAMLATLSTALTAAQELASEGYIITATANSQAADSGVILLGTRVQGDTMARPILVGDAEAGTQYAVFSGGYAVVAVVYQYLQNNGVLWNYIGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY2</accession>
    <name>E8WWY2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta prime subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1490</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579863.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1490"/>
    <dbReference type="EnsemblBacteria" id="ADW68543">
        <property type="protein sequence ID" value="ADW68543"/>
        <property type="gene ID" value="AciX9_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1490"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_0_0"/>
    <dbReference type="OMA" id="DIQHAAS"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="378" mass="41240" checksum="549EFAD7D36AA8C3" modified="2011-04-05" version="1">MTSFPATFPATFTDFLGNSHAIEGLRTAIAAGRLPHSLILAGPQGAGKYTLALMLAMAVECERQPRELWSTGQSLASYCGVCANCTRIASAADLQVLVDNAVAAREDLRETDKKETRVLIQQHPDVLIVPPDPPQLLIKLGQVRTVIQRAQYLPSEGPRKLFIFTASNFMKEAANSLLKLLEEPPDYAHLILCVENIGELLPTIRSRCAVVRLGALPIEELEMLLADRRPEWQPKHRTLVARLAQGAAGKALGFDLEGFTAARADALVMLRGAGDDHSALFKMTETYRAGADGQVKTSMLLRTMGLLLEDLMLLQAGTPELVRNVDMRGELERMAAAVTFGWIEGASRGLDQVTSGMRRNLLRNLSLDAFAEQLANQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX67</accession>
    <name>E8WX67_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unclassified family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2685</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581024.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69709">
        <property type="protein sequence ID" value="ADW69709"/>
        <property type="gene ID" value="AciX9_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2685"/>
    <dbReference type="eggNOG" id="COG3676">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044348_1_2_0"/>
    <dbReference type="OMA" id="IYRRVQR"/>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="128"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="36703" checksum="408B60250EF0EC5F" modified="2011-04-05" version="1">MDYPKTLIEAVRYFSDEQVCIDSVSEMRWPDGKPTCCWCGKQNNTWLATQKRWKCKACRKQFSVKRGTIFEDSPLGLDKWLVAMWMLANCRNGVSSYEIARSLGITQKSAWHMTHRIREAMAPEDGSKLGGADTAVEVDESYIGGKLKNMHNKQRRAFAGSGGDNKNKSIVMGAVDRENKKVRAEVIPAAQRETMQALVQKHVKFGSTVYTDSHVGYTGLKLKYEHDFVNHMTEYVRGQVHTNGIENFWALLKRGLAGTYVSVEPEHLGRYVNEQVFRFNHRWVGKVRHTDATRFKAVLKEIVNRQLTYADLTGRSGQTAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX70</accession>
    <name>E8WX70_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2688</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581027.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2688"/>
    <dbReference type="EnsemblBacteria" id="ADW69712">
        <property type="protein sequence ID" value="ADW69712"/>
        <property type="gene ID" value="AciX9_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2688"/>
    <dbReference type="eggNOG" id="COG0033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_8_1_0"/>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="38"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="209"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="320"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="490"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="545" mass="58998" checksum="78E6211B72D420A0" modified="2011-04-05" version="1">MPNQPGQHPTPDSLVNVPRLIAAYYNLHPDPTIPAQRVAFGTSGHRGSSFLTSFNDDHIAAITQAIVEYRAAQKITGPLFLAQDTHALSDPAFSTALEVLAANDVLVMVDSALSYTPTPALSHAILRYNENRIADLADGIVITPSHNPPEDGGFKYTPPNGGPADTTATKWIENRANDLITNHLAGVKRTTYTKALAAQTTHRHDFLTAYVDDLSNVIDFDPLQNSTLKLAVDPLGGAGVYYWPRILDQYNLSVELLNPHVDPTFRFMTCDWDGKIRMDCSSPNAMASMIANKDKFDVAWACDTDHDRHGIVTRSSGLLNPNHYLAVAIQYLFTHRPDWAQNVGIGKTLVSSSMIDRVAKGLNRPMLEVPVGFKWFVDGLIDGSLGFVGEESAGATFLRRNGKVWTTDKDGLILGLLAAEMTAVTSKDPGQLYNDLTAKYGAPVYQRIDAAATKDQKAKLGKLSPSQVTAKTLAGDDITSILTEAPGNHAAIGGLKVTTAEGWFAARPSGTEDVYKIYAESFEGESHLKQIQQEAQALVTAAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX71</accession>
    <name>E8WX71_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581028.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2689"/>
    <dbReference type="EnsemblBacteria" id="ADW69713">
        <property type="protein sequence ID" value="ADW69713"/>
        <property type="gene ID" value="AciX9_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2689"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_0"/>
    <dbReference type="OMA" id="VWNAARV"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="251"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="392" mass="42829" checksum="36560DC9BEC9D627" modified="2011-04-05" version="1">MSIHTLHIEHVMLLAIYSLLTVANSLLYRNVKGIHWFSLYNVFALLGAIAVELRGQIPDFLSIVVGNLCVMTGYALLFFSLAALAERSIRQTYFQLLLLAAAVVTMMQWGYWHPETKTRLLAYSLILFLQQAHIAFFICFAHAGKLRRVGSAMAVMLAGLAAINVIRILGVSLHGAPSDYLQAGPFLAGIVVANTCLQCGAMVAYVWMTASLLRKELEHQALSDPLTGILNRRAIQKAAEREIALSRQRSLPLSVITVDLDSFKKINDSYGHHAGDATLIAVADCLQQAMRGTDLLARTGGDEFTILLPRTSLQSADEIAERLRSCVEALRVLHQDVETTITASFGLATLESSTLTWDHLINTSDKALYRAKRAGGNIALTTPDPSPTLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX95</accession>
    <name>E8WX95_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2713</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581052.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2713"/>
    <dbReference type="EnsemblBacteria" id="ADW69737">
        <property type="protein sequence ID" value="ADW69737"/>
        <property type="gene ID" value="AciX9_2713"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2713"/>
    <dbReference type="HOGENOM" id="CLU_2698679_0_0_0"/>
    <dbReference type="OrthoDB" id="2092144at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="69" mass="7595" checksum="902489BC965B2850" modified="2011-04-05" version="1">MTHAIEVEIDSLGKVHPVDPLSTLPEGRAILTWQTAPEHETMLLSETALAENWLGPEEDAAWAHLQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX98</accession>
    <name>E8WX98_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ordered locus">AciX9_2716</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581055.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2716"/>
    <dbReference type="EnsemblBacteria" id="ADW69740">
        <property type="protein sequence ID" value="ADW69740"/>
        <property type="gene ID" value="AciX9_2716"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2716"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_0"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="378" mass="42043" checksum="FBB8C14115EE651C" modified="2011-04-05" version="1">MLYWLLYQKLFPYFRFFRIFRYLTFRCVFASLTALLIGLLIGPFVIQRLREFQIGQYIREEGPQSHQKKGGTPTMGGVLICISILVPTLLWSDLSNPFVWVVMLSTLAFGAIGFADDYIKVVNRRNLGLTSRQKLLAQFVVSGAVAVTLIKLQGVGSYSTRLVVPFAKRLRPDLVWEWMGHIPHLHWIAFLPFVFFVMIVIAGASNAVNLTDGLDGLAIGCTIIAAGALTVLTYISGHVVFSDYLELQRMPLVSELTVFCGAMVGGSIGFLWYNAHPAEIFMGDVGSLALGGAIGTVAVVIKQELLLPFIGGVFILELMSVVLQVGSYKLRNGKRIFKMAPLHHHFELLGWSESKVIARFWILALVFALLALTTLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXA7</accession>
    <name>E8WXA7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0368</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578768.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0368"/>
    <dbReference type="EnsemblBacteria" id="ADW67440">
        <property type="protein sequence ID" value="ADW67440"/>
        <property type="gene ID" value="AciX9_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0368"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_0"/>
    <dbReference type="OMA" id="LMWIVAR"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="351" mass="38246" checksum="CED0FB29A6612666" modified="2011-04-05" version="1">MQRNDLLIPSWPGDQLDSPEPPAPEPPSFDAALGAWVLSRHEDVLAAFRSSALAPAGPHTKRPRTAEDQSARRPMRAETLEALSPAQLRDWSAQLTPSIATRISSLPEDAPVDLVADYLSPLCLELAVLVTGIDPIHAAHYARIAEPISASAAEPYDLALRDSAKTATAQLQGCFHSRTETLRDSGFVALAYTLPCLIANAWYALFLRPEQWTLLHTQPDLTDQAIEELLRFAGLTRILFRQATQDLAIGPATIRQGDRIILRLIAANRDPARFPNAKTLDITSREPGQLSLGAGAHACVGASLIRMAAILLTRPLAQAFQQITLGQTVEWQGGSGFRSPRHLPVRLVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXC4</accession>
    <name>E8WXC4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0385</name>
        <name evidence="3" type="ordered locus">AciX9_3167</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578785.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67457">
        <property type="protein sequence ID" value="ADW67457"/>
        <property type="gene ID" value="AciX9_0385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70178">
        <property type="protein sequence ID" value="ADW70178"/>
        <property type="gene ID" value="AciX9_3167"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0385"/>
    <dbReference type="KEGG" id="acm:AciX9_3167"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_3_1_0"/>
    <dbReference type="OMA" id="TIHIEIA"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="341" mass="37378" checksum="8395826F80CD9A42" modified="2011-04-05" version="1">MQIQSVGIDLGKTTFHLVALGAAGKLLVKKKFSKKQLLAYTANLQSSLIGLEACSGAHFLGRALRSQGHDVRLIAAQFVKPFVKSNKNDFVDAEAIAEAVDRKNMRFVPIKTDDQLDLQAIHRVRDRLISRRTAVINQLRAFLLERGLVFAKTPAKLKAAMADILENAEAGLTPLMRNLINTLWDEWKTVERQVEELNDELERISAADAGCTRIRQIPGIGPVVATAIVAAIGNGAAFRKGREFAAWLGVVPRQYSTGGKAKLLGISKRGNVYLRKILIHGARAAVLRIRRDRAPIGAWLDKLDARAHKNVVVVAMANKLARVAWAVLSSGNEYRSTTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE0</accession>
    <name>E8WXE0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0401</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0401"/>
    <dbReference type="EnsemblBacteria" id="ADW67473">
        <property type="protein sequence ID" value="ADW67473"/>
        <property type="gene ID" value="AciX9_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0401"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989604_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="30314" checksum="1CEADF063787AFBE" modified="2011-04-05" version="1">MVERQRFCRGSLSRIALTPALATAVSVIGSVGLPKFCEAQTAVSSSIVTAEEDGGNSVDRPARRAAGQMVGPKLRLYDPAKIDLSLGVFPQLTPTRTVQNFGGEQIQGTTPSVGFLTTFHQQFHAWSGYEVNFAYTRLVENYISESGGATTSTGATVGTFTRGSIGTNVYELSGAYVAKGPGATRRLQTFMLGGPAMLIFQPTTKQYQGSSSVRAAVLFGSGVDYRLSDHLGLRVEYRGLFYKNPDFAAVISNVPVSKQFTVTNEPTVSLTYRFGAYRKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE5</accession>
    <name>E8WXE5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0406"/>
    <dbReference type="EnsemblBacteria" id="ADW67478">
        <property type="protein sequence ID" value="ADW67478"/>
        <property type="gene ID" value="AciX9_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0406"/>
    <dbReference type="eggNOG" id="ENOG502ZH6K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568541_0_0_0"/>
    <dbReference type="OMA" id="INTVHAP"/>
    <dbReference type="OrthoDB" id="2138170at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233466" evidence="1">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="176" mass="19343" checksum="40667FA0482AE848" modified="2011-04-05" version="1">MRMHLGRMAAVCVVLAGLTMSAGAQFNRSDRSSAEVGINTVHAPVPDPLLKGKKAFISYELGDVTAFPSSYSGGPERAYAEFYAQMQAWDRYQLVSDPKDADVVFAVRFVDPPAIPHPQIRIGVSDPHGRVSLWGFVEEVNFAFFKKHRDAAFTETVKELINDVKVLVDPTAPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF1</accession>
    <name>E8WXF1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="11" type="ordered locus">AciX9_0412</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0412"/>
    <dbReference type="EnsemblBacteria" id="ADW67484">
        <property type="protein sequence ID" value="ADW67484"/>
        <property type="gene ID" value="AciX9_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0412"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_0_0"/>
    <dbReference type="OMA" id="HIPFEFN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="94"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="23339" checksum="19CE5DC8062919E1" modified="2011-04-05" version="1">MSNRTKFKMQRALGLELPGLGKPGALEKRNFPPGQHGQTTTRRKLTQYAVQLREKQKLLFHYGLREEQLRRFVRTARGMNSSNWIESLIALLELRLDNVVFRLGFARSIAAARQLVSHGHVLVNGKIMTIGSATLRSGTFVRLTDYAAGAMTEAARNAPRLPLPSYLQFALEGVNDHGVVRMIPTPEHVPFEFNPRQVAEYYAKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP7</accession>
    <name>E8WXP7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ordered locus">AciX9_1610</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579982.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1610"/>
    <dbReference type="EnsemblBacteria" id="ADW68663">
        <property type="protein sequence ID" value="ADW68663"/>
        <property type="gene ID" value="AciX9_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1610"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_0"/>
    <dbReference type="OMA" id="LMMDIRH"/>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="22217" checksum="BE92B526A40DEB5A" modified="2011-04-05" version="1">MRFTPEFMLSATNEAHFPVEAKTYNAPEIAFLGRSNVGKSSLINALLGSKQAHTSSTPGRTRAINFFALHEGSGDKKKIRPSMIFADLPGYGYAKISRSISAEWPSFIEPYLAERETLALAVCLVDTNIPPQPNDSQLIEFFKAMLKPYLVVGTKSDRISGNVLAKSLAALKKAHGVSEILPVSTKTEAGTKELWSRLQSVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY99</accession>
    <name>E8WY99_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ordered locus">AciX9_1676</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580045.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1676"/>
    <dbReference type="EnsemblBacteria" id="ADW68726">
        <property type="protein sequence ID" value="ADW68726"/>
        <property type="gene ID" value="AciX9_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1676"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_0"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="544" mass="59980" checksum="8D61FB4631E7FA22" modified="2011-04-05" version="1">MAIKTDVSPLGQRSAWQALKKHHAEIGKKHMSELFAEDGSRGERYTAEAGGIFLDYSKNRVNDETLKLLVQLAEESGLKARTEAMFTGEKINITENRAVLHVALRAPKSESIVVDGEDVVPAVHEVLEKMSGFADKIRSGEWKGHTGKKIKNIVNIGIGGSDLGPVMAYEALKHYSQRDLTFRFVSNVDGTDFAEAVQDLEADETLFLVASKTFTTLETMTNAHSARDWALDSLKDDSAVAKHFVAISTNAKEVGKFGIDTANMFGFWDWVGGRYSMDSAIGLSTMIAIGPDNFMAMLGGFHDMDVHFRTTPLEKNLPVLMGLLTVWYTDFFDAQTMAVLPYEQYLKRFPAYLQQLTMESNGKHVTLSGEHVETETGPIYWGEPGTNGQHSFYQLIHQGTRLIPCDFIGFYKGLNPLGRHHDMLMANVFAQAEALAFGKTAEQVKAEGVAAELVPHKVFEGNRPSNTILADQLTPAVLGKLVALYEHAVFTQGVVWGIDSFDQWGVELGKVLATRILGEIEGADGPKGHDSSTTSLIERYRANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYD9</accession>
    <name>E8WYD9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="1">MTA phosphorylase</shortName>
            <shortName evidence="1">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnP</name>
        <name evidence="3" type="ordered locus">AciX9_2822</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581160.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2822"/>
    <dbReference type="EnsemblBacteria" id="ADW69845">
        <property type="protein sequence ID" value="ADW69845"/>
        <property type="gene ID" value="AciX9_2822"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2822"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_0"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30906" checksum="ADE830E758F59C9A" modified="2011-04-05" version="1">MDKVEIGIIGGSGLYAMPGLSGLQEVAIETPFGAPSDAYMVGELDGRKVAFLARHGRGHRITPTELNFRANIWGMKKLGVEYILSVSAVGSLKEEHKPTDFVIPDQFIDRTFARIGTFFGDGVVAHVGFGDPICSVVAKAFETACKEVGVVGKLGGSYVCIEGPQFSTRAESNLYRSWGADVIGMTNLQEAKLAREAEMSYATMAMVTDYDCWREGHDDVTVEQVVAVMHQNSGNAAKVVRAAVAALPKGEKSPFAEAMKFAIMTDKTMIPDATKKKLDLLIGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF2</accession>
    <name>E8WYF2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581173.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2835"/>
    <dbReference type="EnsemblBacteria" id="ADW69858">
        <property type="protein sequence ID" value="ADW69858"/>
        <property type="gene ID" value="AciX9_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2835"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_0"/>
    <dbReference type="OMA" id="IHMEVGQ"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="42774" checksum="4BE81F6553281F95" modified="2011-04-05" version="1">MSTATAVKVLSDRIGRIEVSATMAITAEALRLKATGINLSDFGAGEPHFETPRHIKDAAIEAINKGFTRYTAVAGVPEVRKAIVDRHKADFGTDYAVDECVFTTGGKLALFNALQVLVDHGDEVILPVPYWVSFKDIIQYAGGVPVFVESKESENFRVTASMIEAAITEKTKCIILNTPSNPSGAVVSKADLEGIVRLAHERGIYVLLDECYVYLSFDGELFSGASFTDCKEHVVVLGSLSKTYAMTGWRAGFALGPKQIIGAMSKLQSQSTSNAASMVQKASIAALMGSQECVSEMRADYIKLRDRILEGFKSIPGLTCTVPQGAFYVYPNISAFIGKGGIKSASDLAAKLLSEAHVVVVPGEAFGTDEHIRLSYAVSADVIDEGVKRIREFLAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF4</accession>
    <name>E8WYF4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2837</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581175.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2837"/>
    <dbReference type="EnsemblBacteria" id="ADW69860">
        <property type="protein sequence ID" value="ADW69860"/>
        <property type="gene ID" value="AciX9_2837"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2837"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137864_0_0_0"/>
    <dbReference type="OMA" id="ASKRIND"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036929">
        <property type="entry name" value="DsbDN_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233981" description="DsbC domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16705" checksum="A905C69B712CAE21" modified="2011-04-05" version="1">MRKSLALFLLAAPAFAAPKPVVHWQVTNPPAKALKRGTKLNLTLTGQIDPGWHLYALEEPQGGPIATEINLAEGSPADLIRVEEQKPKIVPDPIYQLPTGFFEQSANFTLHLQLDKSASAHPIQILIRYQSCNDRVCLPPHTDTVDVPLTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV4</accession>
    <name>E8WYV4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1742"/>
    <dbReference type="EnsemblBacteria" id="ADW68790">
        <property type="protein sequence ID" value="ADW68790"/>
        <property type="gene ID" value="AciX9_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1742"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="WINSAAY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="499"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1181" mass="126668" checksum="4383CC7110A5D205" modified="2011-04-05" version="1">MVKRDQQNPVNVYGMKSEKQSGSPTTAKWARQIRPAARTTFGGNTMRNTPQYKFGRTSKTLGITAALAFSSLAHGQAVANAKMHGTVTDSTGAVIPNATVVATQLDSNATATAISSDSGSFTLTNLPVGAYSIKISAPGFQTYTRTGITLQVSNDAEIDAPLTIGSSDVVISVNSGASQVQVDDTAISTIVDQQRTVDLPLNGRNAASLILLSGAAAPTVNGNMTSTKSYGSTGTSAIGGSLNIAVAGGQGNQINFLLDGGDHNDSFSNVNMPFPFPDVLQEFSVQTTGLAAQYGVHPSAAVNIVTKGGSNQWHGGVFEFLRNSYPNANNRITGYTDLKRNQFGGYFGGPILHDKLFFFGGYQHTSLRIAPGQTSSFVPTPAMLSGNFTPYLQYQRSLSATNACPTLSASAGFVYNAAACTATINPALFSPAAIALTKYLPTASTLNAAGQVNYRVPAPQDENQWIGRLDQTVSQRHTVFFRYFMTNFYQKSLFNGNLLNAINPGLKDRGKYGTFGDNFTITPSINNALRLTVTRLAIARGAPGDLISPATLGSNVYSSVPNYIYLNVSGAFTASCGSCAPTHYVTNHYQAADDISMQKGKHFLQAGFDYIHEELNLAGINTENGQFTFNGSYSGLGLSDLLLGAPNTFAQAFGPGAAAHLRYNYFGYYAQDTWHAAKGLTINAGLRWEPWFPEYEKNNIGGEFSQANFNANITSSVYTNAPAGIVFFGDKGVKPGFINSRFTNFSPRLGLAFDPRGDGKQSLRASYTLTFEAPELYYDSGFPGNSPNASAQSFTVDNSTNQTDAVKSFDNPWKKIQGGNPYPTAYPAPSNAFFPATNVSTGLYPSNLRRTYMHQYNASYQNQISPNWLLSASYIGTSTVHLWGFQPINYATPQNTPAGATATTNNTSQRYLLYRAAIANNTTAGTRYGAFSSTADYGMANFNGIILTANHRVANNFSLLTNYTFSHCLSNMNYTGDNTPPSQDPNNHAAEYSNCNFDTTHNLTVSGVFTSPKLNSRGLNYALGGWQLSPIATYRTGMPYTVTDGTDVSLTAIGQDRPNQVAGVSRYAKNLYPTPSNGVTPLPLWINSAAYTTQATGTFGNETPLSARGPGFANIDAAVSKRFPIYERANLELRGETFNVLNHPNYSNPNSARSANASTFGRISSTVNDARLFQVAAKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ38</accession>
    <name>E8WZ38_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ordered locus">AciX9_2930</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581268.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2930"/>
    <dbReference type="EnsemblBacteria" id="ADW69953">
        <property type="protein sequence ID" value="ADW69953"/>
        <property type="gene ID" value="AciX9_2930"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2930"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_0"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="14024" checksum="974060FD11E206FF" modified="2011-04-05" version="1">MARIAGVDVPNNKQVRIGLTYIYGIGDSRAAKILTAADIDPIAKVGTLDEDQLNAIRQVIEKQGMIEGDLRKEISLNIKRLIEIQSYRGLRHRRSLPVRGQRTHTNARTRKGPRKGTVAGKKKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ59</accession>
    <name>E8WZ59_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0590</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578989.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0590"/>
    <dbReference type="EnsemblBacteria" id="ADW67661">
        <property type="protein sequence ID" value="ADW67661"/>
        <property type="gene ID" value="AciX9_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0590"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163365_0_0_0"/>
    <dbReference type="OMA" id="IRVHARK"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234000" evidence="3">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="4">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="12970" checksum="CD89B5CF04E8013B" modified="2011-04-05" version="1">MKIRYVLLSTVLCLVFAASYIARPTAAQGAPKRIEVTASKFKYEPSEVTVKKGEPVVIVLKSTDVAHGIKFKELNLQAKVDKGGTGELAFTPDKTGDYVGHCSVFCGAGHGSMTLTLHVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN4</accession>
    <name>E8WZN4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isocitrate dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="2">1.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581322.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2985"/>
    <dbReference type="EnsemblBacteria" id="ADW70008">
        <property type="protein sequence ID" value="ADW70008"/>
        <property type="gene ID" value="AciX9_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2985"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_0"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="339" mass="36424" checksum="30FD743401A1BF83" modified="2011-04-05" version="1">MPTHKITLIPGDGIGPEVTAATVKILEAAGKITGASFEWHTHNAGADAFAKTGEYIPQSLYDSVKENKVALKGPVTTPIGGGFTSINVTLRKKFDLYSNFRPVKSLPGIKTNYPNLDLVIFRENTEDLYAGLEVMINPDIAQSLKIITRKGSLRIAKSAFEYARRHGRKKVHAIHKANIMKLSDGLFLKCCKEVAAEYPEITYAEHIVDNTCMQLVMNPFQYDIILTENLYGDILSDLCSGLIGGLGLVPGANIGVDASIFEAVHGSAPDIAGQDKANPTALLQSAVLMLHHLEETATADLIQKALERVYAEGKTLTRDIGGTAGTTAFSDAVVAALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X030</accession>
    <name>E8X030_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1880</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1880"/>
    <dbReference type="EnsemblBacteria" id="ADW68926">
        <property type="protein sequence ID" value="ADW68926"/>
        <property type="gene ID" value="AciX9_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1880"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="27596" checksum="BD086B9261CFC9F9" modified="2011-04-05" version="1">MATAPAIDPTLINAEGPVAGEVIVTSNLWKTYEMGDQQVHALRGVNLRIKHNEYVAIMGPSGSGKSTLMNLIGCLDSPSQGKYWLNGHNVSELNDDELARIRNKEIGFVFQTFNLLARATSLHNVELPLIYNGTPAAERTARAKEVLEQVSLGPRMMHKPNELSGGQRQRVAIARALVNRPSIILADEPTGNLDSKTSVEIMALFAELHEKGNTIVLVTHEPDIAEYAHRIVTIRDGVVSSDHPSARHAAQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X058</accession>
    <name>E8X058_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3018</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581353.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3018"/>
    <dbReference type="EnsemblBacteria" id="ADW70039">
        <property type="protein sequence ID" value="ADW70039"/>
        <property type="gene ID" value="AciX9_3018"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3018"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067342_0_0_0"/>
    <dbReference type="OMA" id="KMGQPNR"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023856">
        <property type="entry name" value="Bacillithiol_biosynth_YpdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04018">
        <property type="entry name" value="Bthiol_YpdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="37295" checksum="F450AE4416CA627C" modified="2011-04-05" version="1">MDASAKIYDVLVIGAGPTGLACAIDAQRAGFSVVIVDKGCLCNSLFHYPAHMTFFTTPELLEIGDMPFSSPNQKPTRNEALEYYRKVAEHYRLDVRQYETVDRVAGFDGEFTVHMTDRFERGSTLRARKLIVSTGYYDLPNYLGIDGEGLSKVKHYYHEPHPFFGLNVLVIGGKNSAAIAALDLWRHGAKVTLVHRGAEMHRHVKYWILPDINNRVKNGEIAAYFGSTVEKISEDTVTLKTPAGEVTIANEFVFALTGYHPDFEFIEKLGVKLDEANDRCPVCDEGTLESNVPGIYLAGVIVAGERTNEIFIENGRFHGKLIADSLRSKMMVAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G3</accession>
    <name>E8X0G3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0758</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579153.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0758"/>
    <dbReference type="EnsemblBacteria" id="ADW67827">
        <property type="protein sequence ID" value="ADW67827"/>
        <property type="gene ID" value="AciX9_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0758"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_2_0"/>
    <dbReference type="OMA" id="FAFFGEH"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234229" evidence="1">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="57"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="31978" checksum="04F0191C10438EDB" modified="2011-04-05" version="1">MNRNSLPFSVSCAAAAAALALSIAPARAQDWAKAELAKSPRHGEYVTINEANGRKLQAFVVYPEVSGNAPVVVMIHEIFGQSDWAKLMADELAAKGYIVVEPDLLSGFGAPAADSMAGMKMAPGEKMPEDHMHAAAPTGAAFVAATPGGTAAFPDQPSVTKAVSGLDPAIVTADLDAAADYGKKLPAASGKLAVAGFCWGGGKTFAFATHRKDLSAAFVFYGPPPPADSMAAINAPVYGFYAANDARIGATIPQATTDMKAAGKKYEPVTYAGAGHGFMRAGQAPDASADNKKAWDDGFARLLTLLKGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G6</accession>
    <name>E8X0G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0761</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579156.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67830">
        <property type="protein sequence ID" value="ADW67830"/>
        <property type="gene ID" value="AciX9_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0761"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_0_1_0"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="26753" checksum="99DAECE345F382B3" modified="2011-04-05" version="1">MQSRIQGTTMPVLEVLLQPGEAVISEAGELSWMSQSIQMTTHTQMGGGGGFFGAIKRVAGGGTLFMIEYTAAGIPGEIAFATKIPGHILPIEVGQGNEIMVHRHGFLCATQQVQLGVGFQQSLGAGIFGGDGFLLQKISGYGTAWLELSGEVIVKDLRPGEMLRVHPGHVGAFTGGMSFQITRVPGIKNMIFGGDGLFLAALTGPGRVWLQTLPLARLAHQILEFAPSERRQESVQSGVVGGIVGSLLDGMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M5</accession>
    <name>E8X0M5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1930"/>
    <dbReference type="EnsemblBacteria" id="ADW68976">
        <property type="protein sequence ID" value="ADW68976"/>
        <property type="gene ID" value="AciX9_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1930"/>
    <dbReference type="eggNOG" id="ENOG5032UK8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053531_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="42262" checksum="7A3C07D22C8C6ABE" modified="2011-04-05" version="1">MSPARFFDTSPPDRLFLDMPSNRALGSDRISCRLSRLPGLLSLAVVLPGLALSAGAQQRVAYAGALDLPQEPAPQQTVSQQAVAQQGAAIPQGFGSVEGAVTDIDGDFVAGTRVVLSVPHGTATREAVTDDQGRFSFSSVPSGDFSLSITAPGFAAQLIPGSLAAAEQKELAPIVLAVAASVGVDVVISQHDLAEEEIKIEEKQRIAGFIPNFFVTYDWKAAPLTSRQKWELAWHTTYDPAGFLLNAAFAGVEQANNSFSGYGSGPASYGKRLGANVADYTVGTIVGGYLLPVAFHQDPRYFYMGKERGSITHRTLYALSSAVICRGDNGRWQPNYSSILGDLAAGAVSNIYYPASDRNGAALTFENGLLGTVSDAVDNVIQEFLLRRITPHTKPPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R6</accession>
    <name>E8X0R6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1971</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580336.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1971"/>
    <dbReference type="EnsemblBacteria" id="ADW69017">
        <property type="protein sequence ID" value="ADW69017"/>
        <property type="gene ID" value="AciX9_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1971"/>
    <dbReference type="eggNOG" id="ENOG5030N8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352596_0_0_0"/>
    <dbReference type="OMA" id="NWHIDAR"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="490"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="797" mass="83680" checksum="9C9AC0384C4171E6" modified="2011-04-05" version="1">MSTAAGQVTIVLSADKVSYSAALDQAGRELDKLQGKSKSFGHGSVSDMQAASASIRLLENPLGNNMRAIERLISQSKVLSGVMKAAFPLVGAIAIAGMFAKLTTEVVKFIKEMNEMPAVIKRGFDSLNLSIRTSNDELDLTNAKLANQIAKLEGKPQNNLKTALAESRVEADKLATSLANDAKAVNDLLTANKIGLLGQLVGKANTSNVSSSIQSYMNDLQDLGNKISVAAQKPNNDTEVASLRKQLSDKQNSGLGWAKSKMFATDHPDLAGPDDQIMGGDQASNRAELLGFQGVLLGQQHRATSEDTNKQLTGIKDKDEAAKAAAESAKAAARAALEAQKKAAAEQLAAWEESNADWKAAQDRSLLDDADWWKAKLATLNIGSLNYRAVNKKVNADIISDNREMTEARPTWANDFLKDGNANGGISKDDAEQITATGKATAEWIASLRSGVELQKQNATAIAESSLQMAVATGRMTKMDAAQIQANLHTQEYNDRLSELKDNRDAITTNASLSDVQRKAQLANSDNQIAALNNQRALQTQQDNASTNPQGSLASVGFVDALNDFVLASKDAAGQMREITTGTLNTLNGEFVKAISGQRTDFGNAGASIFRNVAGIGLQKAEGSIMQGLGFGAKADGSKSNPLYVRMADGVAGGVGSAAKGLSSLFKSGDGDSGGSAVSGLASKAGGWLSSLAGMIPGFAGGGTVTPGTLAMVGEQGPELAYFGSGAHITPNHKLSSIGSVGGDTHNWHIDARGATDPAQVRYQVQQGIQQAAPHLTAQSMQAKAQQNKRSPSTRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y2</accession>
    <name>E8X0Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3155</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581479.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3155"/>
    <dbReference type="EnsemblBacteria" id="ADW70166">
        <property type="protein sequence ID" value="ADW70166"/>
        <property type="gene ID" value="AciX9_3155"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3155"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="SMKGAME"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26064" checksum="BA926BC440DD304E" modified="2011-04-05" version="1">MRIVIITGGSRGIGAATAIECAKRGLGVILTYNENQAAAESVIEKITKAEGTALALKLDVAESSTFGSFRDSVRVALQSKWQRDDFDCLVNNAGYGAFKPIEAVTEADFMGLFNVHLKGPFFLTQSLLPLMADNGDIVNVTSATTRVATAGVAPYASFKGGLEVLTRYMAKELGARRIRANAVSPGAIRTDLGGGLNDEFEAMLAGQTALGRVGEPQDVGSVIASLLADENRWINGQSIEVAGGYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X128</accession>
    <name>E8X128_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579219.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0826"/>
    <dbReference type="EnsemblBacteria" id="ADW67894">
        <property type="protein sequence ID" value="ADW67894"/>
        <property type="gene ID" value="AciX9_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0826"/>
    <dbReference type="eggNOG" id="COG4911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137908_1_0_0"/>
    <dbReference type="OrthoDB" id="1777117at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="15783" checksum="07EE2D00358DAD40" modified="2011-04-05" version="1">MSKIFTLGEAQTLIPVLGSLVSRARDAAVRANEIESEMQDLSQRIFLSGGLHVDVTAAARRRAERDKSVQSAKSTIDEIEEIGAAVTDLSEGSLELPSELQSRPILLCWSLGEPEIAHWREPEDEADVRRDVDDRFGRERPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X199</accession>
    <name>E8X199_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2008</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69053">
        <property type="protein sequence ID" value="ADW69053"/>
        <property type="gene ID" value="AciX9_2008"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2008"/>
    <dbReference type="HOGENOM" id="CLU_2105522_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="12842" checksum="EF955DD67483C544" modified="2011-04-05" version="1">MLLIVFASLRGGLNQPKRALILIGYCNLAFWLSYVVWMLRLKMVGPSLDIGIDPFAGVLAEWFVLLVLGSAYEVIVFTRGIFSQQQRRIALVGMGVLLIQILTSIQVSYRLLQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D2</accession>
    <name>E8X1D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2041</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2041"/>
    <dbReference type="EnsemblBacteria" id="ADW69086">
        <property type="protein sequence ID" value="ADW69086"/>
        <property type="gene ID" value="AciX9_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2041"/>
    <dbReference type="HOGENOM" id="CLU_1022182_0_0_0"/>
    <dbReference type="OMA" id="VHANTIE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="28001" checksum="29BDD653CAB3D2EB" modified="2011-04-05" version="1">MNLETLELIAWDLDPSPHRPSRIPHVPTLGRDFSIPSPTVIESSTNATDFAQIQTRPDLHEEFAGLDWSLAVVDLRTLQAFQRRLHFDPTHPTPTVNPNSLLTLAFPPPRPTTHTRPTSTTIQSPNPDLTLRPTFTGWQLHGGSPFLEVALFQHRAFLRDGYHRAHDLLRAGLNAVPAVVIHARTLDEIYPQTPNFFPESTTFAPRPPMVTDFLDPTLTLSYPTPRVLKTIRISIQESFEPEIKELHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D9</accession>
    <name>E8X1D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2048</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2048"/>
    <dbReference type="EnsemblBacteria" id="ADW69093">
        <property type="protein sequence ID" value="ADW69093"/>
        <property type="gene ID" value="AciX9_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2048"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418439_0_0_0"/>
    <dbReference type="OMA" id="SADINIM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3857" evidence="3">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="276"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="663" mass="73480" checksum="BFB73E4333B52AFF" modified="2011-04-05" version="1">MGASELRAQWTPPTAEELSMTSQEGAKGAPAVFLYKEQITDDGLRMHSYYVRLKVLTEGGKEYANVELPYVSGSAHLQVDSISGRTIHPDGTIIPFTGKPYDKLVAKGHDYKEMAKVFTMPSVEVGSILEYRYKLHYDDAYFESPDWYVQSDLYMRKAHYMWRPTTQLMQGEHGQTMGRIAWTPILPEGATVKQTDAKGGMRGNGEHEGGIQLDLDVHDIAPLPIESFMAPAASLSYRVMFFYSGYRTMDEFWKSEGKIWSKGQDKFVGPGNGVKAFVQQTVAAGDTPDQKLKKLYEAVMTLENTDFSRERSSQEEKANGFKQLNTTDDVLARKRGNGDQLSDLFVAMARATGFKAYVMGVANRDRRLFIPQYLNIRQLDDDIAIVNVNGKDEFFDPGQRYCEYRHLAWVHGGSGGVRQIDGGGTDMIETPLDNYKEESVKRVADLTLDEQGEATGTVKLTYLGDPALHWRQEALKGDDTSLNLDLRSNLERMLPGGMEVRVTNVTGLSKPDQPLVVDYSVKGAVGTPTGKRLLITGNLFEVNAKPVFPDSKREQAVYMHHPSFVQDAVRFKLPATMTVESAPKEDAAIVPGSIGFTASSKQSGSSITMFRNVTIAKHIFLTKEYPDLRGFYGKLETRDQEPLVLIHPAPGSASAATAAGPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J5</accession>
    <name>E8X1J5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP oxidoreductase coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3219</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581542.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3219"/>
    <dbReference type="EnsemblBacteria" id="ADW70230">
        <property type="protein sequence ID" value="ADW70230"/>
        <property type="gene ID" value="AciX9_3219"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3219"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066353_0_0_0"/>
    <dbReference type="OMA" id="MGVYFNF"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="2">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="3">
        <location>
            <begin position="151"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27396" checksum="A217626BE1B28424" modified="2011-04-05" version="1">MNLGFIGTGTISAAIVEGLAPIQPDTRITVSPRNAARAAALAVRFPNVTIAPTNQAVLDASDTIVLAVRPQIVTETLAALNFRSDHHIISVIPTVTLAWLRSATAPATHITRAIPLPSVAHRHGPTAVYPASPDVSALFNLLGTAITLDREEEFDAFTVATSAMSSYFGFAATLTTWMERQGVDPDKSRIFASQMFQGLSATASAEPNLTFAELAKEHETPGGLNEQVLRTISTAGLLTQLDQALDDILTRIQSGPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P2</accession>
    <name>E8X1P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579285.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0893"/>
    <dbReference type="EnsemblBacteria" id="ADW67961">
        <property type="protein sequence ID" value="ADW67961"/>
        <property type="gene ID" value="AciX9_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0893"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_0"/>
    <dbReference type="OMA" id="LYVQPRH"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="171" mass="18978" checksum="639E7A714AE68C9B" modified="2011-04-05" version="1">MSELPIRVCHPGDEHFLSIVASGTFLENFAGTLDGADVLAHLQKNNSVAKYATWLADPQTHIAVSELLNSPIGYAVLCPPDLPVPLTPTDIELRRIYLFQRFQGTGVGLALLNWSIQKSRDLNMTRLLLGVYGENRKAIAWYHRQGFQTIGTRQFLVGTTLHDDLVLALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V7</accession>
    <name>E8X1V7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2073</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580435.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69118">
        <property type="protein sequence ID" value="ADW69118"/>
        <property type="gene ID" value="AciX9_2073"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2073"/>
    <dbReference type="eggNOG" id="ENOG502ZDK1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186850_0_0_0"/>
    <dbReference type="OrthoDB" id="2090208at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="81" mass="9081" checksum="5478FB175BD07F24" modified="2011-04-05" version="1">MRTTLTIDDDVAALLQKELRRSGEPLKQAVNRLLRAGLYQAATPMKSKPFKVRPFDASLPTEWTSGSIQQLLDIAEGLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X261</accession>
    <name>E8X261_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3293</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581616.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3293"/>
    <dbReference type="EnsemblBacteria" id="ADW70304">
        <property type="protein sequence ID" value="ADW70304"/>
        <property type="gene ID" value="AciX9_3293"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3293"/>
    <dbReference type="eggNOG" id="COG3651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_0"/>
    <dbReference type="OMA" id="TGWFRDG"/>
    <dbReference type="OrthoDB" id="1635990at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="PTHR37466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="14391" checksum="2B1B364D454FD6C4" modified="2011-04-05" version="1">MSDLDTKVTGKGKNVLGQPLAVCGCEPMTGFYRTGCCETGPDDYGVHTICCLVDAKFLEASKALGNDLSTPMPQYGFAGLKPGDKWCVCAARWLQVQQAGAGCPVVLEATHENTLKIVPFELLIQYAVIPDQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X295</accession>
    <name>E8X295_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579351.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0960"/>
    <dbReference type="EnsemblBacteria" id="ADW68027">
        <property type="protein sequence ID" value="ADW68027"/>
        <property type="gene ID" value="AciX9_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0960"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_2_1_0"/>
    <dbReference type="OMA" id="HIHTKVH"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234294" evidence="2">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="31008" checksum="BFFF50112EF72A61" modified="2011-04-05" version="1">MPLPNLSRRRFLSTAVAVAALPLKSVAETTCTLIPEQEQGPFYLADELIRSRIAEDRTGVPLRLKLILMDSRTCTPLRNAAIDLWHCDAMGLYSGFTKTSPGPPPGGPGGPGGPGGPPPGFGDHHGPPPDRDGAGPPQMEPSDKLTFLRGIQFTGDDGAVSFETIFPGFYDGRTNHIHFKVRLEGHRQGDTYAAGHTAHIGQLFFPEFWNLKLMTRAPYANHHIHRTTEGEDNVFNQQHGSAAIANLIQTNPQHIEQGLYAQLRISVDPTATPKPIAGGGPRPPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F1</accession>
    <name>E8X2F1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplS</name>
        <name evidence="5" type="ordered locus">AciX9_2131</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580491.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2131"/>
    <dbReference type="EnsemblBacteria" id="ADW69175">
        <property type="protein sequence ID" value="ADW69175"/>
        <property type="gene ID" value="AciX9_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2131"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_0"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="13701" checksum="A7C324B82247341D" modified="2011-04-05" version="1">MSIHPIMQKLAAKFERTDLPKFAPGDTVRVQVKIKEGEKERLQAFEGMVIAYRRGPQGTFTVRKMSFGQGVERIFPFNSKVVDKVEKVRSYQVRRSKLFYLRGLRGKAARLREVERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S1</accession>
    <name>E8X2S1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M56 BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581680.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3360"/>
    <dbReference type="EnsemblBacteria" id="ADW70368">
        <property type="protein sequence ID" value="ADW70368"/>
        <property type="gene ID" value="AciX9_3360"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3360"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830965_0_0_0"/>
    <dbReference type="OrthoDB" id="1313887at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="38003" checksum="F9A30239CA6D2223" modified="2011-04-05" version="1">MMMSVARHLLESTLFASFMLLLVVLLRRQAASLRHMLLLAAVLKFAVPLEGLQMFGTLLRRRLPQRIEPFQIQLPILDIQRRHSLAQPLQDSTLLHVALAFWVVGTVVLLAIWIMALNKVGKTSLNTAPDHIQALRQASRRLRVTRTVEIRTSTEARDPYLMGLFRPVLVIPESLPETLSAAEYEAILLHELAHAKRWDNLTRSSVHVLVCVFWFYPLLRWLERRIEGEAELACDELVLNAGVTATDYLQGICKVCQQFLLRPLAGRSHVNSFNLRNRMELIMSFSSPKRGVPFSSAFAVLPFSSLRLPQLQPALHLHPMTLRRPVLLQLRIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S3</accession>
    <name>E8X2S3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3362</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581682.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3362"/>
    <dbReference type="EnsemblBacteria" id="ADW70370">
        <property type="protein sequence ID" value="ADW70370"/>
        <property type="gene ID" value="AciX9_3362"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3362"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962293_0_0_0"/>
    <dbReference type="OMA" id="VHESAMF"/>
    <dbReference type="OrthoDB" id="1660365at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="32390" checksum="3D71E71829B5AACE" modified="2011-04-05" version="1">MNVLKDREEAVRSPVVDRTLFQKTLAECIQAAGIDPGCHELIVGGSYEDAEMLRGVGFRRMTLSNVDAVAASGPPRMEGVELDTVYADVEKMPLADGSYDLVLAHAVLHHCRSPHAALLEMLRVSRRNVIFLEPNDSLLMRALVRFRLSFPYELPAVVACGFESGGVRNTCIPNYIYRWDRRDMQKATASFLAESDFALYARSYWDFNVDRAELARRNQTRIGSFTKVLGPGLFLAGLHGFQAVANRLPWVSGQGNKFFGCITKQDRLKPWLVRQGDGIAFKRDYGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U9</accession>
    <name>E8X2U9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579406.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1020"/>
    <dbReference type="EnsemblBacteria" id="ADW68083">
        <property type="protein sequence ID" value="ADW68083"/>
        <property type="gene ID" value="AciX9_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1020"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_3_3_0"/>
    <dbReference type="OMA" id="DYGTDYS"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29996" checksum="B63E2E71B268F4DA" modified="2011-04-05" version="1">MTQHAERFTGRVEEYVRFRSRYPRQVLDVLRERCGLTQSDLIADIGAGTGMLSELFLEAGNPVIAVEPNSEMRAACRMLAARFPKLSISDASAEATGLTKTSVDLVTVGRAFHWFDQERALAEFHRILRPGKWVTLVTNRRSQRGSAQAEEYENILLEFGKDYEQVRGSYRSFEGLRPYGGAETFEVKMQADEQMTLQEFVGQTQSLSVAPLVSEPGFEEMQRALEAFFLKRATKGLLTLETVCEVVGWKTPGDSERSFPEQSNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X0</accession>
    <name>E8X2X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyanophycinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1041</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579427.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1041"/>
    <dbReference type="MEROPS" id="S51.003"/>
    <dbReference type="EnsemblBacteria" id="ADW68104">
        <property type="protein sequence ID" value="ADW68104"/>
        <property type="gene ID" value="AciX9_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1041"/>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053928_0_1_0"/>
    <dbReference type="OMA" id="AAIHKRF"/>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230610" evidence="4">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="30526" checksum="A17AFCF15606628B" modified="2011-04-05" version="1">MSFGWMSGMVRLSFVCSGLMASAALGQVPSHGPAKGSLLVTGGATEARDYQRLVEMAGGAKAKIVVIPNASVTKPTEQAVLQEEYCGAKSPFAAFPGAPCTVLYTNDKAVANTAAFVAPLKTATGVWFVGGRHWRIADAYLDTLTLKEFFGVLERGGVVGGGSAGATIQGSYMVRGSAVPDDNTIMMAPGHEIGFGFMTNVTFDQHVDVRHRENDMAVVIKAHPDLLCFGLDQATSITVHGDTVTVNGPKRVAVWDGKDHDGKGYYHLRTGDKLNTVTRVATVVAHPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y2</accession>
    <name>E8X2Y2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579439.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1053"/>
    <dbReference type="EnsemblBacteria" id="ADW68116">
        <property type="protein sequence ID" value="ADW68116"/>
        <property type="gene ID" value="AciX9_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1053"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_0"/>
    <dbReference type="OMA" id="YEPSIWL"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7362" checksum="E36D818E7419A677" modified="2011-04-05" version="1">MNNRLRILRAERAWSQQDLADRLEVSRQSVNAIETGRYDPSLPLAFRIARLFGASIETIFLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X319</accession>
    <name>E8X319_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S45 penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1090</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579476.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1090"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="ADW68153">
        <property type="protein sequence ID" value="ADW68153"/>
        <property type="gene ID" value="AciX9_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1090"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011790_0_0_0"/>
    <dbReference type="OMA" id="THEVPNN"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="936" mass="102125" checksum="F7DA3299D2AD3983" modified="2011-04-05" version="1">MSLFDPKNSTPDPNLIPFHESDEPRLATRRSIEDEKDPHHPAAIAAGLSDPVLPRPQKRPFLHPTNILKLFFITFPIVLILIVIAFFAAQHFVRSATRANLPQLDGSLAIPGLSAPVTVTRDPHGVPHITAATTDDLILAQGFITAQDRLFQMDLLRRHAAGELAAIFGTAALDHDRLQRTLQIRAAADRAATQLPTDQLHLLDQYAKGVNAAITAQTPHLPIEFRVLHYTPAPWTPRDSILVSLAMFQDLTNAFPTKLARESLTARLPADLVPDLYPVGSWRDHPPTTPEPDLTIPGPPIEQVPLDESQASLHLPSVPWSLIPDPCPSCTPGSNNWVVSGAHTISGKPLLSNDMHLNLTVPGTWYEANLETSASTDPIHVSGLSLPGIPLIVVGQNAHLAWGFTNLGADVQDLYIETTRNNDAEFQSTDGTWQPITHISEHIVVRGGKDETLDVTATRHGDTLTPILTPAIRNEKRQISLRWTLYDPTVINLPVLAIAQAHDWSTFLAAFSTYGGPAQNVVYADDEGHIGYHAVGKIPLRGPARNPDIAEPLPDTIASPEPTRSNTQTPVIAATPDPLTQSPLATPKPAAAPLLSGPLSSIPITPTAASEWSGYIPFDKLPQVFDPADGVIATANSRVVADDYPYPITQNWAAPYRNERIWRLLAHKTTLKPADLLAIQSDIYSDFDHVLAQRLAYAVDHSQLVHNSKPGERAQLLQAADLLRNFDGQMTADSSAAAIVASAHAILWNVLLAPHLGKQPAEDLNQTYLWGERDYALEQIIMHTPPRWLPPNYASWDDLLAAALDQGLQKAKAPADLTKWHYGAIHTVDLESPIFSNSPLLTRLIGIPTGTGSKPQSGDTTTVKQVAKTFGPSERFTADLADPNKSTLNIVLGQSGNPASPWYMDQFPTWYHVTTYLFPFTQTEATHTLTLTPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X364</accession>
    <name>E8X364_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2250</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2250"/>
    <dbReference type="EnsemblBacteria" id="ADW69288">
        <property type="protein sequence ID" value="ADW69288"/>
        <property type="gene ID" value="AciX9_2250"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2250"/>
    <dbReference type="HOGENOM" id="CLU_1364602_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="21956" checksum="B4B38F0883C9F154" modified="2011-04-05" version="1">MASNPLPAELAAQAESIVNTLTQTDYQYNGFIDAEAGIYDCDCNQFVACVLEGLAANHYALIPKESKQPLPRAFEYYLYFSGLGTRTGGWRQIMRLADARRGDVLAWELPLVKGQDTGHVVLVGDTPEEIEDGVWSVRVYDSADKPHFEDTREDGTSGVGSGFIRFEVDAEGRPTGFMFSPEATVFEVRPIAIGRAEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D7</accession>
    <name>E8X3D7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3432</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581750.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3432"/>
    <dbReference type="EnsemblBacteria" id="ADW70438">
        <property type="protein sequence ID" value="ADW70438"/>
        <property type="gene ID" value="AciX9_3432"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3432"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_4_1_0"/>
    <dbReference type="OMA" id="EHVEMYL"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="180" mass="20335" checksum="59BE5F6C81CB3D57" modified="2011-04-05" version="1">MNKRVHSATHPPRRSKERIRESVDDYLKAIYTLGGEEQRQVGSSELAARLCVAPASITNMLQKLAAEADTMVVYERGYGVRLSGSGRRRALEIVRHHRLVETFLYEVLHYPIEELHDEAERLEHFISERFEERVAAKLGNPQTDPHGHCIPALDGTMPDFHGVTCRCGLPELQSQSSASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F4</accession>
    <name>E8X3F4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ordered locus">AciX9_3450</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581766.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3450"/>
    <dbReference type="EnsemblBacteria" id="ADW70455">
        <property type="protein sequence ID" value="ADW70455"/>
        <property type="gene ID" value="AciX9_3450"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3450"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_0"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="352"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="492" mass="54977" checksum="4E357253C0BD40E4" modified="2011-04-05" version="1">MALELFNTLGGRVESLTPADGAVLRMYACGPTVYDYGHIGNFRTFIHVDVLRRYLKQTGIEVKHVMNITDVDDKIIRNAALLKMPIEDYTRKYEDAFFEDMAALGVERPEVLPRATENIEEMVALIERLAEKDIAYQAEDGSWYFRIARFADYGKLSKKDFEGIEDGARVDVDEYEKDAARDFALWKAVKPGEHAWETRLGPGRPGWHIECSAMATKFLGDGFDLHAGGEDLTFPHHENEIAQSESASGTAFARHWMHVRFLLVEGRKMSKSEGNFYTLRDLLLKGHRASAIRFLLMSVPYRHQLNFTFDGLIESTNAVERLRTFADRMRKGSFPEGLNEDLAAATAKALAGYDAALSNDLNTAEARAAIFDLVRAGNSAADAGTVKSGNAAEILKVLERFDGVFAVLVDRDAEITRAALDWAEKDGRMDEAAPELVATLSFSDADIDALVAERTHAKKTRNFARADAVRNELLAKGILLEDTKDGVRWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J8</accession>
    <name>E8X3J8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1126</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579512.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1126"/>
    <dbReference type="EnsemblBacteria" id="ADW68189">
        <property type="protein sequence ID" value="ADW68189"/>
        <property type="gene ID" value="AciX9_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1126"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_230990_0_0_0"/>
    <dbReference type="OMA" id="WQLQANG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230632" evidence="8">
        <location>
            <begin position="28"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2142"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2167"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="9">
        <location>
            <begin position="620"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="9">
        <location>
            <begin position="712"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="5">
        <location>
            <begin position="1367"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="9">
        <location>
            <begin position="1680"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="9">
        <location>
            <begin position="1779"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="9">
        <location>
            <begin position="1870"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="9">
        <location>
            <begin position="1973"/>
            <end position="2048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2221" mass="220280" checksum="6F3717E3EA70EF64" modified="2011-04-05" version="1">MTVSRRFAAASLVALFLPLLQSTFAGAQAPAVATGDTRTVTEPVIPAACQALQASFHDANDDVPASVEAGSTNLDQARLQAALTACTGTGKAVELTQDGAGNNAFLTGPISIPAGVILLLDPGVTLYFSRNAQDYDTTPGTHTCGTVSGASNTASCKNLISITKADGAGIMGFGKMNARGGDVVLNSFATPGYQGSTAGKTWWDIANDATTYNGSQQNPRGIQITSSNNVSLYKFTFRNPPNFHIAINTANGLTVWGIKIVTPYSAHNTDGIDPGNSSNVTIRNSWISDGDDNVAVGAPSALTQNMSIIHNHFFAGHGESIGSYTTGGVNNILFDDNLLYGDADVDGSNSTGIRIKSANDRGNVVQNVQYSNSCFANHGTQMQFTPIYNTNAGTLTPNFKNILLQNLRFSNQGPVPTGSFTFLGASNNGTINPLGVTLDNVTIDTAASANLIAPSNAQITLGPGQVSTNLASLLLPYNGSNGNTITDARTASSLVPPACNFIFLASEITGPSGVSQAVTTGQFPTAVVILTPAIAATGYPYPTGTLTVTDEANRSFTATLTGAGDTTFIPITNAPAGTHSYTASYSGNAVYSAITGIGTFTATVSGGALPATATSISGVPASTTYGTPFTVTANVTGANPTGSLGFLLNGAVYATVPLSGTGASYSFNLPIGSYTISAVYNGDVANAGSISTASNVTLAGAATTTTLQSSTTSTTVGVPVTLTATVSSAAGMPAGTVTFTYTSTTVTHATTLGTATLANGVATYSALLPEGTDSIVATYTATGNYGGSASTNSIQISVQAAPPIPAATAPIALPYTLTTIAGGGTTTSNATCIGHTDTFGDGCAATAVMITGTGTAADLRSVAADPFGNVYFTDANAALVRRVGINGIVTNFAGYVTGTACVPTSTTGCTPTLVKLTGKPRGIYSDPQGDLFIAGYGDNKVQMVGLSDGKMYLVAGTGSGPTNTTDPAGDGGPAVSALLKGPRAAATDAAGNIYIADSGDNRIREVLNPASGLPGAGNIQTVAGTGVTSSTGDGGLATIATISNPQGVAVDTSGNLYISESSHVRVVCVACSSGSGLSALLVKLGVSAPANGNIYTIAGTASSSNPSLTPGLGTTVNMSPQKISLDPNGNLYIADSGNNVVWFEDGRTGYTSLLVGGGTAFTCTGSAIGDGCVATQGIVGSNGGNGFGIGLDGKGNLYVSDSTNLRIRKVLNNLRFPGGPVGAAIAQTVKFHFLPGDTPATLAVSSSEFALSTGNCIANKTDTTTDCTYSVTFTPKVAGLRTSSLGVATSLGNPGTLGLSGNGVGAGATLDPATQLSFGTNVTPNAIAIDNSGNVFVADSGSETVLEYAAGSASQGSAAVGKTVQSFMNPAALATDSMGNVYVADATTGFITVLSPNGTSRTLSTSFSAPRGLAVDALDNLYVADAGAKTLTEIGVNGVAARTLVTAGLTAPGALAVDSNSNVFVADSSAGAVYRIDGQTLASSTVTTAATAPRALAIDAAGNLIIADSSSNQLLAIPANTASAPFAVATGLPANALAMDGAGNLYTASATNQLLELLRTQATTTFNGTAAAPATVSLLSTGNAIANLALTSPDQTNFALAFSTSNGCSGTAAAIVVTTGSTCQFTSTFTPSSRNNFTNTATLAGNAANAALATPPTLEIIQTGNNAPFPVALTFGSSVPASPVVGDTIMLNASITSIYGTPSGTVVFSVDGNALPASPVSNGAASTTVSGLTAGNHNVAATFTSSDPAFANASATAVVLTVQKASANVMLSIDNASQIYGAANSATVTIATSSGTPTGTVQFLIDGVNSGTPVPVSGGIAKYALPTLTAGKHVITAAYSGDSSFASANAAGITVTVSQATAAVALTTNPSTANTGASIMLTANVTSSAGAPSGTIQFFTGSTALGSPVQLTAGIATLSTTALPSGRDSVTATYSGDTNFGTITSLATTVIVKTLPTLALTVSPAIPVAGEPQGQNETFTATLSSASSATGTVTFLDGASPLGAAVALTNGSATFSTNAFAVGTHSITAQYSGDTLNAGAASTPLTFTTLSSLLPGFAASSVSSLTVAAGGSATGTLTLTPGTLYGGTITLSCASPSATLTCSMSPASLTFSTSTSIPQTAAVTVTASANQARLGSPFPGDMGIRLAAIFGLPGLAMLGLRRQNRSRLMLLLLLAAATCGLYSVTGCAGSGANASGNVILVITATDGKNSQNIPVYVTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q1</accession>
    <name>E8X3Q1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2291</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580645.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2291"/>
    <dbReference type="EnsemblBacteria" id="ADW69329">
        <property type="protein sequence ID" value="ADW69329"/>
        <property type="gene ID" value="AciX9_2291"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2291"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_2_0_0"/>
    <dbReference type="OMA" id="NVAIFIW"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="146" mass="16427" checksum="8EFB69F6F722EBA1" modified="2011-04-05" version="1">MILLTRKAEFSAAHFYWNDALSQQENERIFGKCANRNGHGHNYTLEVTVAGEVDPITGFVVDLKKLKDILEQEVVGVYDHRHLNLEIPDFATVIPTTENIAIAIWRRLAGKIPNATLHRVRVYEMPDLFADFYGDFGPEAEAGAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X410</accession>
    <name>E8X410_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FeS assembly protein IscX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3513</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581829.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3513"/>
    <dbReference type="EnsemblBacteria" id="ADW70518">
        <property type="protein sequence ID" value="ADW70518"/>
        <property type="gene ID" value="AciX9_3513"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3513"/>
    <dbReference type="eggNOG" id="COG2975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168040_1_0_0"/>
    <dbReference type="OMA" id="AIQQAWI"/>
    <dbReference type="OrthoDB" id="1860577at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007479">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036762">
        <property type="entry name" value="IscX-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37532">
        <property type="entry name" value="PTHR37532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04384">
        <property type="entry name" value="Fe-S_assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039003">
        <property type="entry name" value="IscX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140319">
        <property type="entry name" value="SSF140319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03412">
        <property type="entry name" value="iscX_yfhJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8550" checksum="5FEDE958F2CF62A4" modified="2011-04-05" version="1">MPREIQWTDAEEIGIQLQEKYPEIEPYTVRFTDLHKYVTELPGFVGDPMKSTEPGLEAIQKAWYEEYEDAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X453</accession>
    <name>E8X453_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0022</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578442.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0022"/>
    <dbReference type="EnsemblBacteria" id="ADW67113">
        <property type="protein sequence ID" value="ADW67113"/>
        <property type="gene ID" value="AciX9_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0022"/>
    <dbReference type="eggNOG" id="ENOG5033UHJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801146_0_0_0"/>
    <dbReference type="OrthoDB" id="2126887at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="36702" checksum="8F2A2242CB2D91EF" modified="2011-04-05" version="1">MQNKLKRRTVEKLGRAASGCVVVLGLGLTLCTTGCLSPLNKHAVALSAATAPVVDGAAVAYNSAESIHDLRENYEAAQQFDAASPVYNPRKIQPLLNDHDIEIRLSVLAAFQAYSRSLVEVTNNTDSPELDAASRSAGEGLSALGNSLAPSIENTLGIASTTATQTIVTTTTPGTTSTTSSLSTTPTPAISPAVRTGIETAVNALGQYLVSKKIKSQLPAIVKTMDPNVTALCQLLEQDLDTLQSQEQLDFNYIINTQTLFLRSAGMDAQHPAIDPGVRREQIMQLPEIVRQQRSADMQLTALKASVVKLAMTHHALAAAAQDNNPESLKDKLSELEAAGSNLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C5</accession>
    <name>E8X4C5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579575.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1189"/>
    <dbReference type="EnsemblBacteria" id="ADW68252">
        <property type="protein sequence ID" value="ADW68252"/>
        <property type="gene ID" value="AciX9_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1189"/>
    <dbReference type="eggNOG" id="COG3565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109157_0_1_0"/>
    <dbReference type="OMA" id="FFLEDPF"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="16038" checksum="AF9BA6DDCE04D27C" modified="2011-04-05" version="1">MSETITPFHIAFPVDDLDAARTFYGETLGCPEGRSSDEWIDFNLFGHQIVAHYKPKSERAEEHHNAVDGHAVPVPHFGVVLTMGKWESLAERLKAASVKFEIEPYIRFKGEVGEQATMFFYDPAGNALEFKAFADMRQVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G6</accession>
    <name>E8X4G6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protease Do</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1230</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579616.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1230"/>
    <dbReference type="EnsemblBacteria" id="ADW68293">
        <property type="protein sequence ID" value="ADW68293"/>
        <property type="gene ID" value="AciX9_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1230"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_1_0"/>
    <dbReference type="OMA" id="NRSVSMR"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="309"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="528" mass="54450" checksum="02367B330B30F505" modified="2011-04-05" version="1">MSASTNNLVSKIKHHALPTAIATTIAVGTVLFANSNGVHASAVTASPLDDHSVSALTSLDTAMEAVTARVQRAVVNISVTSKGNPEEASDGDDQNSSQMQGQGQGQSMQGLPPGFAQFFGQGGGGGQRMVPQQPQVQHGIGSGVIISSDGYIVTNDHVVAGATQIRVALHDRRVLTGHVVGTDKLTDIAVVKVDATDLPAMSWGDSSKLFPGQTVLAFGSPFGFFQDSVTRGIISAVNRANPYSTDARKPGAFIQTDAAINPGNSGGALVNTHGELIGIPNSIISNSGSFAGVGFAIPAQIARATAEQLIKHGHVDHGYLGISMNDVTPENAHFFNLQDASGALVAQVTPNSPASRAGLRQGDVIAQLNGQKILNGSALQVAVSQDAPGTKIALGILRDGKPQTVDLTVGQYGKDDQVASNDAPAGSNKGKLGIGVADLTPDVRQQINAPDQVKGVVVESVRPDSPADDAGLQPGDVILELNRQPASSASQLISQIHNAGNKDLLLLVWSKGNASYRTVRAAQNDQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4J5</accession>
    <name>E8X4J5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma K factor RskA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2368</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580721.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2368"/>
    <dbReference type="EnsemblBacteria" id="ADW69405">
        <property type="protein sequence ID" value="ADW69405"/>
        <property type="gene ID" value="AciX9_2368"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2368"/>
    <dbReference type="eggNOG" id="COG5343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075802_1_0_0"/>
    <dbReference type="OMA" id="KTYELWL"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30536" checksum="6E1589CE8F1695FD" modified="2011-04-05" version="1">MIPVKQIDPDDLPLYAMKLLPPEEMAELTENLQYSIEARKVLAEIYGELSLLAQTAEREEPKPEARMRFMNQVAREKKVIPIDIAAIEAAARAKVQPEIVTVTVEVEVPAKKTLAGKVLPWVGWAAAAMIAVEAGHEFQIRQGAEQSVAAYRSDLAATKESASLSNAALETMKDPAAQHVMLVSAETKPAPQGRVSYAADKGSLVFLASNMGPVDEGKAYELWLIPANGQAPVPAGTFRPDQRGNGSVIMPTMPKGLVAKAFGVTIENEAGSLVPTSPILMKGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P5</accession>
    <name>E8X4P5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2418"/>
    <dbReference type="EnsemblBacteria" id="ADW69455">
        <property type="protein sequence ID" value="ADW69455"/>
        <property type="gene ID" value="AciX9_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2418"/>
    <dbReference type="eggNOG" id="ENOG502ZS93">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115670_0_0_0"/>
    <dbReference type="OMA" id="YAFVERF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14522" checksum="7D80F881C893E3E7" modified="2011-04-05" version="1">MTAWRVYCWAFSVIILLSGLGRVAIAFKKPEAVSRMDILGGLFGILLIPGLLGFAYQRPEGPHLFWIVAIPVQVVFSLCELFAPKMEEWRQKKGTLIYVLTLVFQVALGVPALYALVRYAYFSPQLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R4</accession>
    <name>E8X4R4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ordered locus">AciX9_3549</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581864.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3549"/>
    <dbReference type="EnsemblBacteria" id="ADW70553">
        <property type="protein sequence ID" value="ADW70553"/>
        <property type="gene ID" value="AciX9_3549"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3549"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_2_0_0"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="223" mass="23109" checksum="9326A1CB0ADC19C4" modified="2011-04-05" version="1">MWIKICANTNLDDAQAAAALGADAVGFVFAPSKRQVTAAQVAVITPHLPPSVERVGVFSGTDVEAIASAAEQAGLTAIQLHGGIDLALAHSLQSRLGPKIAIIPTTHWTVGENQQTTEAKVAQDLAALAADPANYRLLIDAKVGKTSGGLGVSYDWTHARPILQAHPTIRVIVAGGLQPDTVAQAIKVLRPYGVDVASGVEEVPGKKSYAKLEAFIKAARGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4U3</accession>
    <name>E8X4U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3578</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581893.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70582">
        <property type="protein sequence ID" value="ADW70582"/>
        <property type="gene ID" value="AciX9_3578"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3578"/>
    <dbReference type="eggNOG" id="ENOG503191E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117574_0_0_0"/>
    <dbReference type="OMA" id="AGWKHLV"/>
    <dbReference type="OrthoDB" id="1763691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234169" evidence="1">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="201" mass="21591" checksum="6FB11F3CA50F9CD8" modified="2011-04-05" version="1">MRALIGSIASAAVLLSSGMIAYGQAYGGPNGGPPMPPPPPPIEQTIATLADQPATHSGFVFDRTMLQVAQSMLESNGMDARRAAVALTAISFDSYRYSQPAFYSPEAMSGLVEQYRAMGWKHMVNANQTPQNTAQPRAMVTDMWLHFSGADIDGVTVLTRSSRDMNLVQVHGDLRPLDLLHLGGHFGIPKVDPNAVMVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Z3</accession>
    <name>E8X4Z3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578514.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67185">
        <property type="protein sequence ID" value="ADW67185"/>
        <property type="gene ID" value="AciX9_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0098"/>
    <dbReference type="eggNOG" id="ENOG502ZTQY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1208388_0_0_0"/>
    <dbReference type="OrthoDB" id="2207518at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="229" mass="24455" checksum="0B6F5B363371B246" modified="2011-04-05" version="1">MMEHTTGSANLPTTVKDSEEGVKSSLDVSAASTAGEPRDGMTASHGGVVSGTPAAQQWKSKSRKRETEASICVSATMIDTEDPAEAQLATVIQDLWTAHGVKLKSATSAKETQGKAKDELAKVKLELAASLHTYKGRFARLGCGGQWSQFLRLQGIPRTTADSYVRRHERSIVGTANCSDGAIRQPTVADVALLVAKITPKLIPLLISDALMKHFLTQVQMAIPLSETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X503</accession>
    <name>E8X503_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578523.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0117"/>
    <dbReference type="EnsemblBacteria" id="ADW67195">
        <property type="protein sequence ID" value="ADW67195"/>
        <property type="gene ID" value="AciX9_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0117"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_16_1_0"/>
    <dbReference type="OMA" id="WPYDINA"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="34584" checksum="2820CF3F7C247E35" modified="2011-04-05" version="1">MPFILRQLQTSDLLVAYLEDGASDGWPIVLTHGFPYDVHAFDDVVPLLIDRGARVIRPFVRGYGSTSFLSPSTMRSGQQAALGRDLIEILEAIGIEGAIVAGFDWGGLASCVAAALWPDKIGGLVSYAGYDIVDIKRQQNGFPLSLEKSIWYQHLFQTDRGRVALTESRKELAGMLWREWSPNWDFDETTLSMTAASFENPDFVDVVLHCYRFHFGLADSDPRLLPLEAVLASRPAITVPCVTLDGTDDPLKPGGTAHHAKMFVGRHEHRVIKAGHNIPKEDPSAFADAILTVRQWLAEGRIRLPYAAISRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X592</accession>
    <name>E8X592_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579679.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1294"/>
    <dbReference type="EnsemblBacteria" id="ADW68356">
        <property type="protein sequence ID" value="ADW68356"/>
        <property type="gene ID" value="AciX9_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1294"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633040_0_0_0"/>
    <dbReference type="OMA" id="FLFNHIY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18516" checksum="A5CC8BD64CC8B375" modified="2011-04-05" version="1">MTLAERLLPELEAELAKTRKVLEAVPDGHNDFKPHEKSMLLNRLAGHTAEFAQNIALILTLPGIDMATPQDPRKILRMETSDALLAEFDGLVPKAIEALKQTTDEAFDETFTLTRQGAPVFSNTRYTAYRNNALNHMIHHRAQLGVYLRLLEQPVPATFGPTADSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D3</accession>
    <name>E8X5D3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2445</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580796.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2445"/>
    <dbReference type="EnsemblBacteria" id="ADW69480">
        <property type="protein sequence ID" value="ADW69480"/>
        <property type="gene ID" value="AciX9_2445"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2445"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634240_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="46053" checksum="504795D423D49E5E" modified="2011-04-05" version="1">MRLTASVTLNAVLFSSSRQHNIWRVTTSNLATGAVAALTAAPIFPTEAAPSALVMSERAGNLLALNAASSTLTSISLVIVGNTPPQQAWDATHWATLKTYRVDMLDAFRKLLFAIVQYLKDGFCEQLLLQCRVCESGQQKPIYLATIGVRDGVVYKTCNLRQRQYVKTFPGVEYWLSVVPILPVLHLALKELCCLVFKAPTYQPSTSKTAYDFVNARSVVSTFISSNPMATVSKAFQTGFGQVLNSGTDYIGTLIQPKAVLPTAVAQVSASSITGKPLTDVQQQLAASNIVVNTQPYQATDVGANITRILGAPTQVAPGSEVTLYTDSTDTVKSFSVTSAQVQQLQGQINQVSNAQVNVSAASTTITGLSSQLDAVKAQLTTLQATHAQDLATRDAQIAQLTSTSQQLAASVTEVQTNLSKINIGVIKPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F2</accession>
    <name>E8X5F2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HGSNAT_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2466"/>
    <dbReference type="EnsemblBacteria" id="ADW69499">
        <property type="protein sequence ID" value="ADW69499"/>
        <property type="gene ID" value="AciX9_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2466"/>
    <dbReference type="eggNOG" id="COG4299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029171_4_0_0"/>
    <dbReference type="OMA" id="NCSVRGD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HGSNAT_cat" evidence="2">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="41918" checksum="DE94B513C2F0705F" modified="2011-04-05" version="1">MTSAPSVLPFVRVAPRVLSIDVLRGLTIALMILVNDPGDAGCVYPQLQHAEWNGYTAADLVFPNFLFLGGASLVFSLQGRIERGADRWELARGLGRRGVNLIALKLVLAMLPSFRLRRIRIFGVLFRTAVCSVAGGLILLGTLEIPMLVGIVGAMLTGYYGALRISFGRMNAPLLDPENNLAAALDRKVAHLLHGELHTGALYNVTHDPEGLLSSVPAVGTTLLGAVAALVMRHPRLTQGQKVGVLAASGVGALGVGSVWGRSFPVNKNLWTSSYVLVAGGWSLLALGGIYWCLDVRRPSARTLRAIRPAQIFGANALVAYAVSVAGHKVARTVHVPCDGHSVSLRTFAYRRGFARGGSTRLRSLGFAVAYAAVCFLPNLILWRRKVFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5J4</accession>
    <name>E8X5J4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3618</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581932.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70621">
        <property type="protein sequence ID" value="ADW70621"/>
        <property type="gene ID" value="AciX9_3618"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3618"/>
    <dbReference type="HOGENOM" id="CLU_2342811_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10548" checksum="67D4649F57A4E99D" modified="2011-04-05" version="1">MSLSPTTVPRNTIPSSLRKPIQSTRISPSPYRSAHATLLTNMKSEARTAPAALKSRFSLMPKESEDAKITGSTRSLERRLLALNLSGSRMARINPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5K5</accession>
    <name>E8X5K5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3629</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581943.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70632">
        <property type="protein sequence ID" value="ADW70632"/>
        <property type="gene ID" value="AciX9_3629"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3629"/>
    <dbReference type="eggNOG" id="ENOG50334X0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452530_0_0_0"/>
    <dbReference type="OMA" id="NARELEW"/>
    <dbReference type="OrthoDB" id="1918995at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="21149" checksum="0C302C1B25C4E511" modified="2011-04-05" version="1">MDARNLHFLLAVCVFSAALLAIAGYYLIRTRRVSHSTWEDLLDELAFVNRNNIALIAHDLIDDPNDPTRPTDGRELDPSQVWTLIGGMDGLEILQENCEVLIKLASYLQQFYPEAIVVAEQLRLNARELEWHIGRLKGAAQVDKLESVFPDYAQRAVTTYYKMTRSLITLYQQLDQSRLAALESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P8</accession>
    <name>E8X5P8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3674</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581984.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3674"/>
    <dbReference type="EnsemblBacteria" id="ADW70675">
        <property type="protein sequence ID" value="ADW70675"/>
        <property type="gene ID" value="AciX9_3674"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3674"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876111_0_0_0"/>
    <dbReference type="OMA" id="TLGCHAQ"/>
    <dbReference type="OrthoDB" id="1678187at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233715" evidence="2">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="75"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="35055" checksum="5EDD65EDCB41AD0C" modified="2011-04-05" version="1">MNAVAKPLLALALVASSFGCHAQKPAAGTLSPELYRRVEILIRTRAKIPPNYLIHIGPRTPSDVPGYDSMEVSFTADGQQSKPVTFLLSNDGKTVAQFSKYDISANPLTVVSGTDRPARGGPQGAPVEIVGFDDLECPYCAKMHSQIFPALTQRYGDKVRFVYKDFPISQHPWAMRAAVDVNCVATQSSQGYWNLVDTIHAHAGELGGTDHNLQKALDSLDKMTLDEAAKEKLKQPEVEACIKKQDDTKIKASLKVGEDLNVEATPVLFINGEKFEGAYPLEDLYRFVDSALIAAGQTPPPPYVPPAAPATPSDNAPAPVTKPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Q0</accession>
    <name>E8X5Q0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3676</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581986.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3676"/>
    <dbReference type="EnsemblBacteria" id="ADW70677">
        <property type="protein sequence ID" value="ADW70677"/>
        <property type="gene ID" value="AciX9_3676"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3676"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_5_2_0"/>
    <dbReference type="OMA" id="DHACGGV"/>
    <dbReference type="OrthoDB" id="1837979at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="152" mass="16719" checksum="BE97DDC590581F4C" modified="2011-04-05" version="1">MSDHEVKLPFVDRSTPPAEGIVRVTFLPEDKTVEFPFDTLPYEGHGRPMSFLDVAENYGIFLDHACGGVCACTTCHLWVKEGAKGVSEAEDLELDRMETAADIQLSSRLGCQAVIERPGTYVVEIPKWNRNYVQEGKPVSGAPGRDYGTVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V3</accession>
    <name>E8X5V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4042</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70837">
        <property type="protein sequence ID" value="ADW70837"/>
        <property type="gene ID" value="AciX9_4042"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4042"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_0"/>
    <dbReference type="OMA" id="WLMQRAF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="426"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="57090" checksum="88EAF92AA49AE082" modified="2011-04-05" version="1">MANLVDELVRQKGDCEVAVHESGVFHLSDLHNEVCAMDTFLRQAIALRPGQPVAIYRSNNRECFHWFLAIIRAGGIAVPLNPQLSLVEVRRILADSGTEILITDRMVFERNVGDRQALEVRTWIQADDEKETLDGFLRLSEMGMPASPVIIDPSATVAIFHTSGTSGFPKGAALSSNALLGARASTVLSGLLLGSRDLALIALPWSHIMAVSIALYGLMAGIRGCFLERFDVEAALDLVERFHVTAFVGVPTMFARVVNSNPAPARLASVRVWLSASDHLPSEVRGRLRQFGALSWLFGRRIPPVILNGYGLVELGGLAMMGIELPLLRGSGDLCFPVPPFHIRLVDEKGQTVPVGVTGECQIRRRGLAPHYWKDKVKDEAQGLLTRDGWLRTGDLATRNRLGLILLVGRTKDVIKSGGYSVYVRELEEAILAHPAVARAVAFGLPHYEKGEIPVAAVELQTGSFCEEADLVDWCRSNLAAYKAPRRIWILEPGALPQNHSGKFLRRVLKERFTDAVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W6</accession>
    <name>E8X5W6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4061</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572762.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70850">
        <property type="protein sequence ID" value="ADW70850"/>
        <property type="gene ID" value="AciX9_4061"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4061"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="RPQHIAG"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233720" evidence="1">
        <location>
            <begin position="30"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="138"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1195" mass="129660" checksum="A12FA0D1BA46B44E" modified="2011-04-05" version="1">MTKNRKYDVLTLLATPCLVLTLLSGGVSASAQFGSASVVGYVKDPSGAVVQDVSVTLRNVSTGVSQTGHTDKEGKYEFDSVPIGNYLISTALANFQASKTEVFNLSTDARQRVDVNIKPGSVNEVVEVTSAAQLLDTETSSRSEVIGQKEVENLPLNGRSYADLVLLTPGVRKSMLENQTASSREAAFNINGQRSAFNEFLIDGLENSNYGTSNQGFEDENIAPSPDAVSEFRVESNNYAAEYGRMPGAVINVSTRSGTNQFHGAVWDYIRNTDLNAFGPIQTATGNKPGLIRNQFGATTGGPILHDKLFFFADYEGVRQIFTYQQAAVTLPDSEQRAGQFLLHRVDGTTSPVPLYNPLTATAYTTGNIAPASTPFALAVLAALPANNVTGSNGTTSPTYNNITNNYSNAPRGTINDDKGDIRVDQSFAKWKIFGRYSEHRAAIFDPPTVGGPAGGNANSNVNIQNRQIVGGATWIISQNRLLDFRFGYTRNIGAKTPYTQGQTSLLTQYGITDGLPTDPSLVRSLNAQSISGFTQLGNQSSSPQYQNPTIYNPKINYTLVHGNQSLKFGYEQQIIHTTVNDFNPSYGQDNYASRYAAGPSGLFPTCSGTVTTACIPTDTAAGNTASTQIQEAQEVADFLFGNRSSYSLTNYTVVQLRQRYFAGYFQDDLKVTPSLSVNVGLRYEIMTPQFEANNRLANFNPATNTLTPASNGSLYNRTLVHLPTKNIAPRFGFSKSVDAKTDVRGGYGLVYVQFNRAGGENNLTYNGPDVVNATVNNNNSIYPTPTSLCTTDSQVQTLCFRQTQQGYSNILTSPAYFNPLNVTSRYVDPNFKTGYVQSYFLGIQRQLPGSLLFDISYVGNKATHLQILADYNQANPCLAAVASTCGNYQSRRPVPTFGDVEIAYGSGIANYNSLQVKFEKRAGALYVLNSFTYSRAFDLASGHLEMNNGDTSRVNYANPRNDYGPSSYDQPIDNTTSIVYDLPYGHGRQFGAHSSRVANALLGGWQATVINTITSGLPFNMIYSSSSSSTTTSQLNGTGGATIGELFASDLDNLRPQHIAGSPLKGTNVTVLPTSNINKVNKSRGLSGYLPGAGQYTSYDYPSYTRYGNVSAWGNVSRNSLRSFAYYNTDVGLHKQFPVVTERVKLDLRAETFNVLNHTNWQAPDTNISDGTSFGTITTAFPSRQLQFAAKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X615</accession>
    <name>E8X615_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Flagellar hook-associated protein 1</fullName>
            <shortName evidence="7">HAP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgK</name>
        <name evidence="10" type="ordered locus">AciX9_4119</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70899">
        <property type="protein sequence ID" value="ADW70899"/>
        <property type="gene ID" value="AciX9_4119"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4119"/>
    <dbReference type="HOGENOM" id="CLU_012762_1_0_0"/>
    <dbReference type="OMA" id="KPQAAYM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="8">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="9">
        <location>
            <begin position="397"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="457" mass="45882" checksum="769A3EAFE0CA5A2B" modified="2011-04-05" version="1">MISLMSTLNTASEALMAQEAEISVTNNNIANASTAGYTRETVSLQEAAPTSQGALSVGNGVEVAGITSVRNELLTSRIQQQTSEQGSSDAQVTALTQIQTLFPSTGTSLASSLSGFFTSLSALSSNPTDAANRQTVLSSAQTLVQQFNSVSAGLSGPASSLNTTVKTDVAQINELSSEAASLNQQITSQSATGQSSGTLTDQLGQVETQLASLTNISVTHGTGGDTITTGNGTPLVLAGQSHALQTSTGSDGNTHILDSSGTDITSAISSGDLGGTIQIRDTVLPGLQTSLDTLANQFATAFNSAQASGYTQNGTAGAALFSIPTTVAGSAAAISLTTTDPTAIAASSDGSSGSSGNVANLVALQNSALPSGQSVTTGSANLVYQIGNLTSNATTQQSSISLSLSSLTTQQSSVSGVSIDEESANLIRYQQAYEAAAKVVSTISTLFDTTINMISGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X649</accession>
    <name>E8X649_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two component, sigma54 specific, transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4153</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70933">
        <property type="protein sequence ID" value="ADW70933"/>
        <property type="gene ID" value="AciX9_4153"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4153"/>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="KRTLYHR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="113"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="38408" checksum="F316A99A1FECFD0A" modified="2011-04-05" version="1">MRWEVIEAQSGSEALELLHAEKGTDVLLLDPLLPDLLPAEFCGMVRQRYPGIEILTMNANTGHVLVGSSSPTPFASQLAELLYQGTAAVSVKPAVTPTEYLRRSKAGPGLRGMIGDSPVMQNAYALVHMVAPRDTTVLITGESGTGKDLIAQAIHMISPRQKSPFIVVNCAAIPEALLEAELFGYAKGAFTGAMQSRIGRIHAAHGGTLFLDEIGDMPLSLQSKILRFVEQGEVQRLGSNDNLRVDVRVVAATNAALPTMVKDKLFREDLYYRLAVFPIKLAPLRDRQQDVTSLAHFFATKFCPGVTVTARAIEALYKHDWPGNVRELRNVIERASILAGTEREITAKEILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X695</accession>
    <name>E8X695_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4200</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70979">
        <property type="protein sequence ID" value="ADW70979"/>
        <property type="gene ID" value="AciX9_4200"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4200"/>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="YPICASD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1585"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1610"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="5">
        <location>
            <begin position="270"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1665" mass="166060" checksum="1BB1522521F98342" modified="2011-04-05" version="1">MKASGFRCVRVCLVIPLSGLVKDTMVIRSLRSLFSFAAVAVLLLSGSSAVQAQASDAGSLSSAVAVPSRITAKVDNASRVTLGHTMHPLANAANDRGALADATPLNRIHVVLKRSDAQEASLKGLIGDLHNPSSASYHKWLTPDQFGKQFGPSDGDIAAVQTWLQSQGFAVGTLNAGHQTLEISGNAGVFKKAFGAEIHKYLVNGQTHFANASDPQIPAALAPVFGGFTSLNNFRLRSYAKALGEASYEPATKKVTPSWTTGDSSGVSFALSPADFAVQYDLPATSTGTTGAGQTIAIINDSNINVYLVNQYRSLFGLPVNAPTVIVEGQDPGVDGINNPAGPNGDSVEAYLDVELAGSVAPNAAIDLVIGADTELQTGLFLAAERAVYSNIAPIISLSFGGCEINQGTGNQFINSLWQQAAAQGITVLVSSGDNGSAGCDNDNTQDYAVSGHAVNGLGSTPYNVSVGGTDFYYSTYAQGIGSTVLTTQLGNYWSLTPNNSTPTTTIKQVIPEQPWNDSQYGLNIESAYQNSGGQDTSIAGGSGGPSTCGIYSTTGTTCSPYPKPSWQTGAGVPADGARDLPDVSLFAANGLNLSYYPICASDADCQPVAAGSTVQFYGVGGTSASTPAFGGIMALVNQLYGRQGQANYTLYPLATQFPAAFHDVTVGTNSVPCAIGSTNCIAVTNPITLGGTQEGQIGTGTTAQYNATAGYDPATGLGTIDTNVLLANWNKVTFAASTTTLTPSTTTFAHGTAVTISGGVTGKGTPTGTVALMTDSGTSSQQGLTDFTLASGNYTGSVTTLPGGTYNIFGVYSGDGTNGASTSGKTSVTVTPEAGALALDLLSGSVNSNGQIAPSVLGANASIQYGQYFSLSAIVAPTSALAADRSCTFAGNFACSAGFTRPTGNVVFSDSGTVANTAPLNAEGVTSYSYAPTVGSHSITAAYSGDPSYNAVTSSPAALTVTKNTPNLTYSTINVNNNGQVIGGQQSVITLLVENSISLNGLSAAPTGTVTVTGGPAGTPTSVTLTQSVDYYYGAPIGMATIIVPANATPGNYKISLTYNGDSNYVTNGGSVSLTFVAGSGLTSTTTGTLSAPSSTPAALEQVTVTIAGQSGKAAPTGTVYALVSDGNPNQNQNVLILNSAKLPTSTTSNVTVTLAFSSASLLQGTNTVTLFYAGDSTYNSSSGVVTIQNLLSDFTLTAATPSVKIPASGTVTDTLNIASTNGFTGSVALSCSATGGVTCTVNPTVTLTSGQTLPVTVTLNGAGVTTSGSYLATITGVDATGKYVHTAGIQAIVGAISTTPNFSLSPASSSVLVAIGATATDVVTVASLNTFNSAVTVTCAGVAGVTCTAAPATVTPASGGSATSTLTLTGVTAGTYSVVVTGTSGTLVHTANVSVTVTGPVVPDFTLTAASSTASITLGTAPTTTDVITVGVVNGFNSAVALTCAAPTGVTCALNPTSTTGAGTSTATLTGTVAGTYSVVVTGISGTLSHTATISVTVSAAPVPGFLLSANAQALSVVGGQSVQDGINVTAVNGFTGSVALTCSAPSGLTCSVAPASVTPGTAANLTITTTTSAAKLEGAPSGLFGVAGGTVLAGLVCLLIPGKKRRWPALLAVMFCAAALGMATGCGGGTPSNPSMNYNVSVSGTSGSITTATTVVVTVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X697</accession>
    <name>E8X697_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572893.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70981">
        <property type="protein sequence ID" value="ADW70981"/>
        <property type="gene ID" value="AciX9_4202"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4202"/>
    <dbReference type="HOGENOM" id="CLU_069623_3_0_0"/>
    <dbReference type="OMA" id="GGMMTKP"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="136"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="27397" checksum="E59A44C045D04549" modified="2011-04-05" version="1">MSTYPNGRFVWFDLMTSDVPAAQAFYTSVVGWSARDAGMPGDYYTLLSAASTDVGGIMPIREHLAAAGAKPTWMMYIGVDDVDAFAARVKDAGGVIHRAPEDIPGVGRFAVVADPHGATFVLFWGNGEPREATPATPGHVGWHELLTEDLDAAWAFYSNLFGWTKAQTVDMGPMGLYQTFVVNGPQGGGMMNKPPNLPVSFWGLYFTVEGSVTAAVERAKEAGGQLLQGPHEVPGGAWIAHCLDPQGATFNLTSATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D9</accession>
    <name>E8X6D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572935.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71023">
        <property type="protein sequence ID" value="ADW71023"/>
        <property type="gene ID" value="AciX9_4247"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4247"/>
    <dbReference type="HOGENOM" id="CLU_007884_4_3_0"/>
    <dbReference type="OMA" id="GCGTLWL"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="377" mass="39881" checksum="E52394F31E112F6C" modified="2011-04-05" version="1">MAAFDVVIVGAGIVGSACARECVRAGFRVAIVEGGVPAGGATAAGMGHVVVMDDSPAQLALTTYSRGLWNAELPELPRTVEYEARGTIWVAADDEEMVEVHAKQATYERVGVCAEVLDSTDLATQEPNLRSGLAGGLLVPDDGVIYPPAAAQFYLSEARRLGAEFHLSRAISAANGVVLLADGTRLTAPHIVLAVGTECDLLPALPIKKRKGHLIITDRYPNFLHHQLVELGYLKSAHKVVTDSVAFNIQPRQTGQLLIGSSRQYGDEDPRADAAVLRQMLERSMLYMPALANISALRVWTGFRASTADKLPLIGPAAGLSDDKSLWLAAGFEGLGITNAPGAARLLVDGLLGHASQIDASPYLPIRLAAQVEATHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K4</accession>
    <name>E8X6K4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71154">
        <property type="protein sequence ID" value="ADW71154"/>
        <property type="gene ID" value="AciX9_3872"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3872"/>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="YDTNADP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="457" mass="51662" checksum="75D66637F33D5204" modified="2011-04-05" version="1">MLTKDLEVRGEPGGGNEADVEPEPAEILKQLERVVGSSLFRNSKRYPSLLRYIVGEFIAGRSDALKERALGIEVFGRDPDYDTNADPVVRISAGEVRKRIAQYYQERGHEDELRIEIPLGSYQPRFFRPFEDRRSTQTQPEARFRDNAAVPPELHDLHPEPTASSVITPTSIAALDPPLKAKIRQPRFLRITRLHLIWIYGLLLCALIPLILFGWQKYQGRQLRPGAAFFWDRLLHSSEPTLIVLGVHSFDAQGNDISYVSHVLLPQTQQTLLSAMTRSDMVQLNDLTSYVRLTTLLTQNAHSFYTQGATDTTLEQLRRGPFVLIGGFNNLWTTNLTKQLRFRFVTLQNGRNCIQDSQRPERIWTLDTQQKALSNTRDYGMVDAFFDQETDQYVLIVAGIGMSGTEAASEFLTNEQGLAAWLQSSKSGAGDNVQIILSTDVIEGKPGQPQIVESFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K8</accession>
    <name>E8X6K8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3877</name>
        <name evidence="10" type="ordered locus">AciX9_4336</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 11">
        <name>pACIX902</name>
    </geneLocation>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">pACIX902</plasmid>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71158">
        <property type="protein sequence ID" value="ADW71158"/>
        <property type="gene ID" value="AciX9_3877"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71289">
        <property type="protein sequence ID" value="ADW71289"/>
        <property type="gene ID" value="AciX9_4336"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3877"/>
    <dbReference type="KEGG" id="acm:AciX9_4336"/>
    <dbReference type="HOGENOM" id="CLU_077149_3_1_0"/>
    <dbReference type="OMA" id="EMRSSRY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="15898" checksum="0B11953FB51327A9" modified="2011-04-05" version="1">MSTIIHAAVGYFFLLLTVRVLTRRPGAQMTLFEFVIVFLIGGVIILATVGHDRSVTNCAMAILTVGLLHRSVSYAKTKSSTFGAIVDGTPLVAVKDGAWQAEVMTGMSLAPEDIMAAARLKGVKSIFNVKYAVLERNGAISIIKVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6M7</accession>
    <name>E8X6M7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3900</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582195.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71177">
        <property type="protein sequence ID" value="ADW71177"/>
        <property type="gene ID" value="AciX9_3900"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3900"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_0"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230804" evidence="4">
        <location>
            <begin position="27"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="5">
        <location>
            <begin position="664"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="745" mass="79318" checksum="EF630A04E8F8D6B5" modified="2011-04-05" version="1">MKLKYFGRKGLALISLALPIAAVAQAAPQHAWDQKALSSGERAALVLKQMTLDEKIAFIHGYGMPIEPGADALSNGGAGGNVGVPRLGIPRIEMADAAYGVTRSAPNGRYATALPSVLAATSSWEPKSAYAYGALIGTELRQQGYNMTLGGGVNLTREPRDGRTFEYAGEDPLLAGTMDGNLMRGEQDQHVLGDIKHYAINDQEDGRFAVNAEIDKRSMRESDLLAFQIALEIAHPSAVMCSYNRVNSVYSCENDYLLHDVLKGDFHFDGFVISDWGGTHSTAKASHAGLDMEQPEDFFYGAEMKKQVQAGTVPMAELDDHVLRILRAEFASGVVDDPPQKGVVDADHGNNVAQTLAEKSIVLLKNDHSILPLDASKPMTIAVIGSHADVAIIGGGGSAQVDPPGGSPVPPPPPGNGVFDALIRPAWFRDSPLKAIQAEFPKAHVVYASGDDIAAAASLAHSADVALVFGSQWSAESLDLKTLDLGPDQDALIAAVGKANPRTIAIVESGGPIVMPWHDQVGGIVEAWFPGIRGAEALASILSGAVNPSAKLPVSFPLTEADLPHPKLNTPPAASEPHINKGDTLHDVMKELGDGLPTFPMVYDEKLKVGYKWYDAEHTNVLFPFGHGLSYTTYAYSGLSVERTATGLTIHFTVQNTGKRAGDEIAQVYAALPASAGEPPHRLVGWSRLALAPGESKLATITVDRRMLSIFDEKQNAFSLLPGSYQLLVGASSRDLGLKQEISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N0</accession>
    <name>E8X6N0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3904</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582198.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71180">
        <property type="protein sequence ID" value="ADW71180"/>
        <property type="gene ID" value="AciX9_3904"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3904"/>
    <dbReference type="HOGENOM" id="CLU_962881_0_0_0"/>
    <dbReference type="OMA" id="PLNVYVR"/>
    <dbReference type="OrthoDB" id="1654773at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234453" evidence="1">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="27653" checksum="413A839D94A21DA3" modified="2011-04-05" version="1">MRIANVVLGIGVATASVAFAQAYPEGPFSPSSTIPIAFSKTVDANKAHVGDIVLARTMQPIQRANGEIIPAGAKVTGHVTAANAFAFNRTPYAIQTASTLAVHFDLISTASTSYPLNVYVRAMADPINSWDARKPKPSDEDEDGTLTQVGGELFKPHQGEVINTDEDVVGYSRHGNIVAHLIASQGNSPSGCGSGTTEQPVAIFSANACGLYGFSGTNLVSSGRSEDASTVTLSARRNAAVISKNTTALLEVLPDRLSNDSLHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q4</accession>
    <name>E8X6Q4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3928</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582222.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71204">
        <property type="protein sequence ID" value="ADW71204"/>
        <property type="gene ID" value="AciX9_3928"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3928"/>
    <dbReference type="HOGENOM" id="CLU_682894_0_0_0"/>
    <dbReference type="OMA" id="CTNTERI"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234257" evidence="2">
        <location>
            <begin position="24"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="164"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="403" mass="44242" checksum="32674498098BDEBD" modified="2011-04-05" version="1">MPVTFSRSLILCLCASFAWSQQAPLATTPAKATNDQVAAMVGRLELDRYKATIKGLTQFGDRRQGTDRNRAAVDWIEAQLKSYGCTNTERIKYDYQPPAPGAPRTPRPTDPTVGPGGSRKRGNIQPDTVNNDPMKQPDVKLRQLNTQPSTPGEREEVYCTKIGSKHPDQMYILGAHMDGIGWGEAANDDGSGTALVMELARILSMPDVKTDVSIRFALWNNEETGLNGAAAYVAQRKDLQGIESPAGSGKYPEPKWLGMVQHDMMMFDHGMPLKDGTMSKQQRPEADVNIEYQVTSKYADEAMKMAQKFQLADDKYATDYPANVGPHMTNTDSSPFMGLTPSLSLREVERGAQMGAGWDPQHHQPTDVYSFYNDDDFRLGLNSAQITLGAIGNLSGATLTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6W8</accession>
    <name>E8X6W8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3791</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582099.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71077">
        <property type="protein sequence ID" value="ADW71077"/>
        <property type="gene ID" value="AciX9_3791"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3791"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="IRQDGIN"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230819" description="TonB_dep_Rec domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="468"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="929" mass="98333" checksum="2D6AA3E5E3BF659B" modified="2011-04-05" version="1">MINSRHSLRSSLVPLSFLALSLAAPGLSAQEFRGTISGSVTDPTGAAISGAQVLIRETATGTLNKTLTDASGQYVVPFLPPGTYEVSVEMTGFKKVLRSGLTLESAAHPIIDLTLPLGNTQETISVNADTPLVDTANSSVGQVITTHQVEDFPINGRTPLVLTELAVGVVATSYPSQVHPFDNNGASSFSIGGTPQQTSEILLDGSPDTVWSGAIAYSPIQEAVQEVSVRAFDTDAGFGHTIGGVMNQITKSGSNAYHGSLYEFGVVSPLGANSYFNKHVSNPANIKPRPVPHFNQFGGTFGGPIRIPHVFNGTDKLFFFVAAEGLPDSTPSSTLLTVPTAAERTGDFSALLPLGCPKGYLGTDPSHCSDGTVNAYQIFNPFTAVQNGTTVTRSPIANNNLAAAGLPLNAIALNYLKLYPAANIPAANADGTQNYISNSPASDSFNNEFIRIDWNMSARSHMVVDYRRNLRINHKFDYFDNGATGQGSTRGNRGATVDEVFTVNPSTVLDVRANWTDNYEYTYPASTSFSPTTIGFPASLTAGSRFPMLPFLNFSTFQTLGFNTASNDPAQSYQLFGDLVKVAGRHTIKVGGDGRQYRLDLTTFGDASGNFTFGPTFLQSSSSGSAPKPVAYELASFLLGLPTAGNYTQATTANMHAYYMAFFVQDDWRVNDNLTFNLGLRYDHQNPQEEKLSRVVNGFNPTAATNVSGAAAAAYAASPISQVPAGSFNTSGGLTYPTGATNGAIYQTLSHNVSPRIGFSFTPPALNKKTVIRGGFAMFVQPINLSNLGANGTTSSSAQVNNEGFTSTTPYVATNNNYLTTANTLSNPFPNGFTVAPGSSLGASTFLGQTVAFAAPAVHDPYSLRWNLGVQQSLTPSLLVEVDYVGNHSVHLPVGATQLNVIPRQLLSTLATRDNTLAASYNGTSCLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X759</accession>
    <name>E8X759_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4341</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573012.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71293">
        <property type="protein sequence ID" value="ADW71293"/>
        <property type="gene ID" value="AciX9_4341"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4341"/>
    <dbReference type="HOGENOM" id="CLU_056689_1_0_0"/>
    <dbReference type="OMA" id="HAANVRY"/>
    <dbReference type="OrthoDB" id="1564715at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="296" mass="30487" checksum="7CFAF167B1E9C509" modified="2011-04-05" version="1">MSRYNLKSLLCPTETVNVEQLETDRRILAFDRTIQHLNRRGFLGAMLSAAAIGMVAGEREAHAQTATASITDVLNFALNLEYLEANFYLYVTTGSGLSLSLNGGGLAVQGAPPKIALTANTMAVAQALANDEVNHIADLRSAITSLGGTPIAQPLINLSANGAVTTQAQFLAAARQFTALGGSAYVGSAQLLVSNPSVLTTAGQILGAEGQHAGALAYLCVTQNVVSPAIDAQDIPPTATNYFTVDAVNALSPARNTSQVLGVAYGKSTATTTTPTTGVTMGGFFPNGVNGNVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K5</accession>
    <name>E8X7K5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573158.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4494"/>
    <dbReference type="EnsemblBacteria" id="ADW71439">
        <property type="protein sequence ID" value="ADW71439"/>
        <property type="gene ID" value="AciX9_4494"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4494"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_0_1_0"/>
    <dbReference type="OMA" id="FLWFIEG"/>
    <dbReference type="OrthoDB" id="1872329at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="CDD" id="cd09872">
        <property type="entry name" value="PIN_Sll0205-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041705">
        <property type="entry name" value="PIN_Sll0205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="14025" checksum="1E3D51809671E855" modified="2011-04-05" version="1">MTVLLDTHALLWAILSPETLSSKASSTIADERNTILVSTASAWEIATKVRVGKLPGAEAFERDFLDIIEIAGYNLLSIDVESALRAGRLTSEHRDPFDCMLAAQALAKDIPIISLDAKLESFGVRRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L8</accession>
    <name>E8X7L8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative relaxase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573171.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4511"/>
    <dbReference type="EnsemblBacteria" id="ADW71452">
        <property type="protein sequence ID" value="ADW71452"/>
        <property type="gene ID" value="AciX9_4511"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4511"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001748_0_2_0"/>
    <dbReference type="OMA" id="HRETTHI"/>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014059">
        <property type="entry name" value="Conjug_relaxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02686">
        <property type="entry name" value="relax_trwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112956" checksum="A58C5C2817783A4F" modified="2011-04-05" version="1">MMTMSKALSAPQARTYHAREFVSEQANYWSRDQQGHSEWQGKLAAEWGLKGEVGAEHFARLTEGEHPMTQEQLVWHQPSRTYENRYGKDVTSVGHRAGWDATISAPKSVSLTALVGGDERVREAHRESVQVALSEFERYTQARMGNVREPEKTGKFIAATFEHDTARPVDGYAAPQLHTHIVVFNIAESKDGDTHALQERGLFQSQAFATAVYRTELAARLQELGYEIERGEHGQPEIKGYSREYLEASSPRRAQITTELKEIGREGAGAAQVVAHRSRDSKEIQSAADVLHRHRDLAAQYGHQADWVVSRSFSNQRSQEIDAPKVAQQAVTFAREHAFERAAIQDERVILQAALNRSMGQASASQVRQEFERRAQDKQEFRTAEHAPKSAGRQYTTAAMVRMEREIVSRMQNGNFALENSPELSEAKSRAELLSRHSQLNGAQQKAAEQILASQEKIVGLDGVAGAGKTTTLAVIREGAEANGYRVEGFAPTSRAAQKLGEAGIETSTLQLHLAKGQQADTGQKRFYILDESSLASTKQMHDFVTRLHPNDRVLLVGDTRQHEAVEAGRPFAQLQDAGMRTAKLDEIVRQRDAALKQVVQQLAQGQVGEAVQGLERQGRVHEVPNQAERIAAIAKEYARQPENTLVVSPDNRSRAEINQAIRNELQKSDIVGREEHRTVVLVPRQDLTGAERTWAERYHFNDVLLYSRNSKETGLQKGEYARVKSVDAAANQLTIVRADGSELTYDPRRQQGVSLYRDQEKAFSVGDRIQFTAPANDLKIANRELGTIQGFTDDGHMTLKMDSGRSVSLDPREHSHLDHGYAVTSHSSQGHTADRVLIHIDTELGAKDLLNNRMAYVAVSRGAQDAQIFTSDREQLPQVLSREVSHQSAHVPEVQQEPERQQVRLTGRELVEQHARRWNPLNEALPADEAKQFAWQRESGTMQTYQHIQTGRHLHIDGQNGTFHNQHREAITTTQALDFAMPGGQKHSHSLEIKPEREISIGGHGFGIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N3</accession>
    <name>E8X7N3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573186.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4527"/>
    <dbReference type="EnsemblBacteria" id="ADW71467">
        <property type="protein sequence ID" value="ADW71467"/>
        <property type="gene ID" value="AciX9_4527"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4527"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="IRIRALC"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="134" mass="14429" checksum="C595023BA0D3B7AB" modified="2011-04-05" version="1">MAITSQPIAFVVDDERNIADTLAIILGKNGFVATPFYNPLLALSAAALGPPDLLISDVMMPELSGVDLVIRIRALCPNCRVLLFSGQADTTDFRLLARSAGGMSILAKPLHPERLLKEVWKQNPAWEAGSARMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T4</accession>
    <name>E8X7T4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4588</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="9"/>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4588"/>
    <dbReference type="EnsemblBacteria" id="ADW71518">
        <property type="protein sequence ID" value="ADW71518"/>
        <property type="gene ID" value="AciX9_4588"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4588"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_0"/>
    <dbReference type="OMA" id="GPTFKMK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="307"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="501" mass="56562" checksum="35A7ACFAD29EEB5D" modified="2011-04-05" version="1">MNWCLGASLAEWTELDNTVSLCALSRMGSGGKAVIQRSTCNVGLAALDGLVALIITVSAIVYSNYSLAGFHGLISRPINVVDAVFGLSFIVLWQYCFSVLQLYDRFATIPSRMAAILKGVLVMAVPVMFHLGFFHPRLLRFQTVILTVAALFAFEVDRIGFRELVVSWVASRNPQHILIIGSGRRAGKAWREIRTRYHSSTKVFGFVDDRDPSEMAPDIADRYLGRIDDLDELLLRLTADILIIAMPIQSCYPEMQRAVTMAEKVGVQVIYLQDIYATTHKNEQPNRQLFQELFPRHENYVMRLAVKRVVDIVLSALGLLLLSPLFVCVFVAVKMTSRGPAFFKQNRFGYRRRLFPMIKFRSMVIDAEQRMAALENANEAGGPIFKIKNDPRVTPLGRFLRSTSIDELPQLWNVLRGDMSLVGPRPMSVRDVSLFSEATLMRRFSVKPGITGLWQVNGRSHVGFDKWIELDVRYIEHWSLLLDMKILLQTVTTVLKRSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W4</accession>
    <name>E8X7W4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4618</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573267.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71548">
        <property type="protein sequence ID" value="ADW71548"/>
        <property type="gene ID" value="AciX9_4618"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4618"/>
    <dbReference type="HOGENOM" id="CLU_010686_0_1_0"/>
    <dbReference type="OMA" id="FTTQIMG"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="223" mass="23991" checksum="95643861397BDCD8" modified="2011-04-05" version="1">MENGKFVSYLRVSTARQGISGLGLEAQRAAVAAFLDGGDWTLVEEVLEVESGKRNDRPALATALKLCRKHRATLVIAKLDRLARNVAFISNLMESGVEFVAVDMPQANRFVVHILAAVAEQEAEAISKRTKAALAAAKARGTKLGGRRVSAERFAEIGAAARQVRSQKASQVRSELVPTITAIRATGASSLRAIAAELNARGIPTPRRVGHWSAVQVQRAMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W5</accession>
    <name>E8X7W5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573268.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71549">
        <property type="protein sequence ID" value="ADW71549"/>
        <property type="gene ID" value="AciX9_4619"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4619"/>
    <dbReference type="HOGENOM" id="CLU_1924617_0_0_0"/>
    <dbReference type="OrthoDB" id="2176345at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233779" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="131" mass="14634" checksum="CF6B02434EE81C60" modified="2011-04-05" version="1">MKTIAAIAAFLLIFSPANTQTVDWSSAWGKYNADTHRLCPSQKLEDLSDGQYDDVLDGFLPAYPAAVRSRISTIVNYPKTCAAETAGFSCEFGAHLRSFQRIGLRHAFVAYSCRHWRCEEATLCKQLAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X811</accession>
    <name>E8X811_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4665</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71595">
        <property type="protein sequence ID" value="ADW71595"/>
        <property type="gene ID" value="AciX9_4665"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4665"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_0"/>
    <dbReference type="OMA" id="RIIYHRV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22210" checksum="62E75AB1D6C04159" modified="2011-04-05" version="1">MRPAKRYEFMPKTLIGYARCSTDKQDLTAQREALTDLGVAADRIYVDHGLTGTNRARPGLNQALAAVRKGDTLVVPKLDRLARSVPDARSIADELAARGVTLALGQSRYDPADPMGKMFFNILATFAEFEADLIRLRTREGMKIARAKGRLRGKQPKLSDKQQKELGRMHGTGQYTISDLAELFSISRPTVYRTLLRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X819</accession>
    <name>E8X819_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71603">
        <property type="protein sequence ID" value="ADW71603"/>
        <property type="gene ID" value="AciX9_4674"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4674"/>
    <dbReference type="HOGENOM" id="CLU_1118930_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233785" evidence="1">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="26507" checksum="2015A96F29FB31BB" modified="2011-04-05" version="1">MRSKVILPLSCLLFAAATCLAHAQTSVPYIGCSGDGQTGPYLAKTGSPKPVNLPPAVAAQLAWYEYSGDAGHFGTLGPRGWNCFATIGSDGWTLYVAPEVLDGPKLLEHKKWKGFTGPAIQFSGSDGETSGRFEVAKVVARVFPAHRGYARKIIAEGFGSPSDYPFGAFLSDQLNYKSKELVEFTTPAHRRGLGTMSWLLPSDQPITGFALLSIGSDVDTELMQLSFRLPPSLSFLASTLIKQGESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV89</accession>
    <name>E8WV89_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578592.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0190"/>
    <dbReference type="EnsemblBacteria" id="ADW67264">
        <property type="protein sequence ID" value="ADW67264"/>
        <property type="gene ID" value="AciX9_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0190"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_0"/>
    <dbReference type="OMA" id="HFAIGNF"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="350" mass="37937" checksum="8D84E545199C2B1A" modified="2011-04-05" version="1">MAAKPIAQDDLDHILAATRPLWEQMRGERIFITGGTGFFGCWLLESFCHANRSLDLKACATVLTRSPEVFRAKLPHVTDDSAITLHEGDVRDFEFPEGEFRFLIHAATEASAKQANEAPLEMLSTILAGTQRTLEFAASHGTRKLLLTSSGAVYGKQPSNLTHVPESYTGAPNSLDPASVYAEGKRASELMCALHAKATGMECKIARCFAFCGPHLPLNAHFAIGNFIRDVLAGRTIQMGGDGTPRRSYLYASDLMIWLWTILLEAPSLVPFNVGSDEALSILELAHAVIRALNSNVAVQVAKEAMGGGAVARYVPQVDRAAELGLRQTVGLEEAIRRTAAWYGPDKESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD9</accession>
    <name>E8WVD9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="10" type="ordered locus">AciX9_1325</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579710.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1325"/>
    <dbReference type="EnsemblBacteria" id="ADW68387">
        <property type="protein sequence ID" value="ADW68387"/>
        <property type="gene ID" value="AciX9_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1325"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_0"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="58689" checksum="FC1215E8DD61E52F" modified="2011-04-05" version="1">MAKQILHGEDSRQAILRGVNILANAVKVTLGPKGRNVVIEKKFGSPTITKDGVTVAKEIELENALENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGVKTVAAGANPMALKRGIDKAVEAIIGKRDEHGVVQGGALSAFSKPVSGDMIAQVGTISANSDAQIGTIIAAAMNKVGKDGVITVEESRTMETQLDVVEGMQFDRGYLSPYFVTDAERMEVALENPYILIYEKKISSMKDLLPLLEQIARTAKPLVIIAEDVDGEALATLVVNKLRGTLNVAAVKAPGFGDRRKAMLEDIATLTGGKAITEDLGIKLEGVKIEDLGTAKRVTIDKDNTTIVDGGGENSKIEGRVKEIRAQVEKTTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDAMHATRAAVEEGIVPGGGVALIRCSAAVDALIKTLEGDEKIGASIIRRAIEEPLRMIVSNAGEEGAVVIGKINESKDSNFGYNAGTGAYEDLVAAGVIDPTKVTRTALQNAASISGLMLTTEAMISEIPEKKEAAGGGHNHGGGGMDGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF9</accession>
    <name>E8WVF9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1347</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1347"/>
    <dbReference type="EnsemblBacteria" id="ADW68407">
        <property type="protein sequence ID" value="ADW68407"/>
        <property type="gene ID" value="AciX9_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1347"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419066_0_0_0"/>
    <dbReference type="OMA" id="GGTTQNQ"/>
    <dbReference type="OrthoDB" id="514419at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026950">
        <property type="entry name" value="Caps_assemb_Wzi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14052">
        <property type="entry name" value="Caps_assemb_Wzi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234078" evidence="2">
        <location>
            <begin position="23"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="654" mass="72232" checksum="B4AC63D3094C1B62" modified="2011-04-05" version="1">MLKRVLIPAVGCVVFTVSPSFAQTPVEPVPAVPSTQAPAAPKPQPGQPDQYPAAPAYAPNPTSTPQAPVAEPVAPPVIAPAPTTPQAPFGALPPYSGADQRLQVYQPYGTPDEKVKKEHNGSTYIPMDSWIYPEMSRLYSLGFADTAFQSMKPYTRMSLTHILDESEDDIRESDSDEAKEILAVIRRELQDETGFQGQGRGLVYGTHDVYTRVMGITGTTLRDSYHIGQTIENDYGRPYQHGFNNITGFAALAEKGRFSLYVRGEYQHAPTGVGYSQALSAEISAIDGIPFSGFNLHQATISTGPVAAQNPFRLVEATLSFHLLGNEISGGKSDAWLGPGQGGSVAWSNNAENIYSFRINRVDPLHIPYLSAILGPVRYDFFYGSLKGHTAPNDDWTHSAMFSFAPTSNFQFGFQRTVIFGGHGHEPVTIHTFLKSFFDVSDTTAAEKNGRDDPGARFSVFNASYRMPFVRKYVTFYADSIAHDDVTPISAPRRAAFRTGLYLSQIPGMRKMDFRVEAVDTDPRVSRSTGGTFNYYEGIQNQAYTNQGFIMGDWIGREAKGGQAWLTYHLSGKEWVQLEYLNKKNDKDFIPGGTTQNQFKAQVLKRFAHDNIELNAWFQYEKFKAPVYLPGAQNNTVTAVQITFFPGLKSIQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVG8</accession>
    <name>E8WVG8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">AciX9_1356</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579739.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1356"/>
    <dbReference type="EnsemblBacteria" id="ADW68416">
        <property type="protein sequence ID" value="ADW68416"/>
        <property type="gene ID" value="AciX9_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1356"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_0"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="OrthoDB" id="1384786at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="199" mass="21171" checksum="9CCDA4607E313256" modified="2011-04-05" version="1">MNVPSNLTLAITGASGSVFAAEMLRLLEADARVTKINLVVSESALRVLAEELQLSGRTALPEKLLGHASVKTQHHADPDIGANIASGSYPSDGMIVLPCSMGTLAGIAHGMASNLIERAADVCLKEARPLILCVRETPFNKIHLRNMTLAADAGATLYPVMPAFYNQPQTSAEMAGQFVRRVLGHIGLPQADAFKWQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ0</accession>
    <name>E8WVJ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1379</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579760.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1379"/>
    <dbReference type="EnsemblBacteria" id="ADW68438">
        <property type="protein sequence ID" value="ADW68438"/>
        <property type="gene ID" value="AciX9_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1379"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148789_1_0_0"/>
    <dbReference type="OMA" id="MAKYALY"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10877" checksum="6F5B587BA483CAFF" modified="2011-04-05" version="1">MAKYALYAELKPKPGKEAEIEAFLKQGAEMAKDEKGTVTWYGFKEDNGTYGVFDTFDDEAGRDAHLNGEIAKALFAVADEYFSEAPKIHKIALLAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVK8</accession>
    <name>E8WVK8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0880</name>
        <name evidence="3" type="ordered locus">AciX9_1437</name>
        <name evidence="4" type="ordered locus">AciX9_2505</name>
        <name evidence="5" type="ordered locus">AciX9_3743</name>
        <name evidence="6" type="ordered locus">AciX9_4656</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573305.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67948">
        <property type="protein sequence ID" value="ADW67948"/>
        <property type="gene ID" value="AciX9_0880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68493">
        <property type="protein sequence ID" value="ADW68493"/>
        <property type="gene ID" value="AciX9_1437"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69537">
        <property type="protein sequence ID" value="ADW69537"/>
        <property type="gene ID" value="AciX9_2505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70743">
        <property type="protein sequence ID" value="ADW70743"/>
        <property type="gene ID" value="AciX9_3743"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71586">
        <property type="protein sequence ID" value="ADW71586"/>
        <property type="gene ID" value="AciX9_4656"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0880"/>
    <dbReference type="KEGG" id="acm:AciX9_1437"/>
    <dbReference type="KEGG" id="acm:AciX9_2505"/>
    <dbReference type="KEGG" id="acm:AciX9_3743"/>
    <dbReference type="KEGG" id="acm:AciX9_4656"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_3_1_0"/>
    <dbReference type="OMA" id="EMGDGKQ"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="37989" checksum="C005222200DA06E4" modified="2011-04-05" version="1">MQIHSVGIDLGKTTFHLVALSAAGKVLLRKKFTQKQLITFTANMQTSLIGMEACSGAHFLGRALRAQGHDVKLIPAQFVKPFVKSNKNDFLDAEAIAEAVDRQNMRFVPIKTDDQLDLQAMHRVRDRLVARRTSVINQLRAFLLERGMVFAKTPIKLRQAMPEILENAESNLTPRMRNLVSLLWSEWKDLQQQIVAMNEEVEQIASSDPACQRLRQIPGIGPLVATAIVAAIGNGAAFHKGREFSAWLGLVPRQHSTGGKARLFGISKRGNRYLRKLLVHGARSAVLIVKRERSPFGPWLDGLEQRAPVKVVITAAANKLARMAWAVLSSGNDYRPATAPMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV8</accession>
    <name>E8WVV8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="6" type="ordered locus">AciX9_3716</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3716"/>
    <dbReference type="EnsemblBacteria" id="ADW70717">
        <property type="protein sequence ID" value="ADW70717"/>
        <property type="gene ID" value="AciX9_3716"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3716"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_0"/>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="56"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="30964" checksum="56149FE58C974EA2" modified="2011-04-05" version="1">MMNLATLPTETRNPRSEHLDELSTLDMLTVINDEDATVAAAVRAVLPGVAEIVDAIAARFERGGRLFYLGAGTSGRLGVLDASECPPTFSVEPGLFVGLIAGGDSALRRSSESSEDKPEEGARDLLTFDPTPNDTVLGIAASGRTPYVLGALAAANDAGCLTVALTCAGGLEGGSPMGHVAEMAVEVATGPEVLTGSTRMKAGTATKLVLNMISTGVMVRGGMIYGNLMVNVQTSNAKLVDRGVRIIAAATGFEKERAAELLEAGSSVKIAIVMGKLGISREAAQERLSAHKGRLAEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX6</accession>
    <name>E8WVX6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3734</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582044.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3734"/>
    <dbReference type="EnsemblBacteria" id="ADW70735">
        <property type="protein sequence ID" value="ADW70735"/>
        <property type="gene ID" value="AciX9_3734"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3734"/>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144805_4_0_0"/>
    <dbReference type="OMA" id="PPEMVHI"/>
    <dbReference type="OrthoDB" id="1897062at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10512" checksum="B1C4C75AA7B16D9E" modified="2011-04-05" version="1">MAASETISVALSPEILTVVHEAVEAGEYASSGDVVRDALQEWTEARRLRQVEHGDLRRLWQQSIESDVSVSADEVLDRLERKYQLMADQAAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW07</accession>
    <name>E8WW07_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0239"/>
    <dbReference type="EnsemblBacteria" id="ADW67313">
        <property type="protein sequence ID" value="ADW67313"/>
        <property type="gene ID" value="AciX9_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0239"/>
    <dbReference type="HOGENOM" id="CLU_2897880_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="62" mass="7130" checksum="16262FABDAAFE1CF" modified="2011-04-05" version="1">MTSFSYEIQEFAGMNPTPFVPLEASAEVSLSDLMVELQQENTRLKLLVSELLLTNQRLRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW15</accession>
    <name>E8WW15_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0247</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578649.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0247"/>
    <dbReference type="EnsemblBacteria" id="ADW67321">
        <property type="protein sequence ID" value="ADW67321"/>
        <property type="gene ID" value="AciX9_0247"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0247"/>
    <dbReference type="HOGENOM" id="CLU_2669850_0_0_0"/>
    <dbReference type="OMA" id="MRTTVDI"/>
    <dbReference type="OrthoDB" id="2090208at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="8401" checksum="FED25062D820F1F2" modified="2011-04-05" version="1">MRTTIDIPDPIYRELKARAAREGTSVKQIILRSVASAPAKAEAVSAKVKGRYPLLSSKEPGALKLGEEGVYEYIPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW19</accession>
    <name>E8WW19_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0251</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578653.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0251"/>
    <dbReference type="EnsemblBacteria" id="ADW67325">
        <property type="protein sequence ID" value="ADW67325"/>
        <property type="gene ID" value="AciX9_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0251"/>
    <dbReference type="eggNOG" id="ENOG5033GXQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134986_0_0_0"/>
    <dbReference type="OrthoDB" id="2040496at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18588" checksum="FFA58447727F9608" modified="2011-04-05" version="1">MALADDLLLQARDLANWGESRPRQASLRRSVSTAYYALFHLLVQDAAKRLSPGSPNGLTQQIGRAFVHGDMKQACKSITAQPTSVLLTLRPQGFSLRLQSVAGTFVNLQEQRHAADYDLTRTYTRIDVLNVVDTAQDAFADWRNVRRTAEANVFCAALLFHRTWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW49</accession>
    <name>E8WW49_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0283</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578683.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0283"/>
    <dbReference type="EnsemblBacteria" id="ADW67355">
        <property type="protein sequence ID" value="ADW67355"/>
        <property type="gene ID" value="AciX9_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0283"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_0"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="184" mass="20698" checksum="479AF0D54C6A6CA1" modified="2011-04-05" version="1">MQIIDTPLFDVKLIRPRRFGDDRGWFAEMFNTQAFAANGLPAQFVQDNQSFSAKGVLRGLHYQLERPQGKLVRCLSGHIWDVAVDLRRESPDFGKWAAFDLKPLNDAGELELLWIPEGFAHGFLVLSETAEVLYKTTDLYHPLGERCVKWDDPTLAIPWPLEGITPSISGKDALGKTFAEADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB4</accession>
    <name>E8WWB4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579818.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1444"/>
    <dbReference type="EnsemblBacteria" id="ADW68497">
        <property type="protein sequence ID" value="ADW68497"/>
        <property type="gene ID" value="AciX9_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1444"/>
    <dbReference type="eggNOG" id="ENOG5030G4A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094318_0_0_0"/>
    <dbReference type="OrthoDB" id="1728831at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="20124" checksum="F7D7FC1A3CD4C246" modified="2011-04-05" version="1">MIAGHFGFAAIVKSREKTAPLWALMLATVWIDVVFIPLFVAHRETAQQVHAGYGGLIIHADYTHSIVGMLALSAILGAMFLPRLGRRVALVIALVSVSHWVLDLVVHRGDMPVLPGNVGNLPSFGFGLWNHPQAAACVELVLVLVGAATYWRAAMDVSVQAGRSKTLASISAGLIAACGLVVLFLDYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH0</accession>
    <name>E8WWH0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein AciX9_2609</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2609</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580949.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2609"/>
    <dbReference type="EnsemblBacteria" id="ADW69634">
        <property type="protein sequence ID" value="ADW69634"/>
        <property type="gene ID" value="AciX9_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2609"/>
    <dbReference type="eggNOG" id="COG1666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099839_1_0_0"/>
    <dbReference type="OMA" id="SDFDRQE"/>
    <dbReference type="OrthoDB" id="1612988at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="166" mass="18411" checksum="82573893C78B3FF6" modified="2011-04-05" version="1">MAADNSFDVVSKVEIQEVKNAIDQASKEVNARFDLKNSKSKIELEKEEAIQLASQDEYTLGAVIEILSQKLVKRGISLKNLEYEKIEPASNSSVRQKIKLKQGIASDAAKKIVAVVKDSKLKANASIQGETVRIVSKDRDVLQQVMGKLRSGDFGIELQFTNFRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWV1</accession>
    <name>E8WWV1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0357</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0357"/>
    <dbReference type="EnsemblBacteria" id="ADW67429">
        <property type="protein sequence ID" value="ADW67429"/>
        <property type="gene ID" value="AciX9_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0357"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569575_0_0_0"/>
    <dbReference type="OMA" id="DWSYGGS"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="496" mass="54949" checksum="4926376948CBDCDF" modified="2011-04-05" version="1">MRWKLHPIAELAGNGAFKIKMTRIKRWYGLLGCGVLAALAGLMAQGAGAQEAPPAPAAKPFFARWGDFYRGDWAPPAVQAASAQDAAAAPTRRGLPSPLDSPPFPNSDWSYGGSPVIGEPDGQSYPLMSAINGAKSRVKVYGWVEPTVNGSTSAHDNFPVANDETANRLELNQFVLYVERLPDTVQQKHFDWGFHLTSLVGTDYRFTTGKGYFSGQLLNKNNSYGFDPSLEYVDLYFPKVAKGMNVRVGRYISIPGIEAQLAPNNYTFSHSLLYSIDPFTDTGVLATVKLTDQWLVQGGLSAGHDVAPWTSDAKPSGTACVSYTTKSVNDNVYVCANGINSGKYAYNNLQQYDATWYHKFSKRLHSATESYFMYERDVPSVAGPVVPETGANGAFCRAGVNRCTAPEWAAVNFLQYEANAHNFFSLRTDFLNDKKGQRTAYQTRYSEETVSWTHWWGTTVQLRPEMRFDRAWDRAAYGKGTHQNQFTVASDLIFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWX8</accession>
    <name>E8WWX8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1486</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579859.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1486"/>
    <dbReference type="EnsemblBacteria" id="ADW68539">
        <property type="protein sequence ID" value="ADW68539"/>
        <property type="gene ID" value="AciX9_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1486"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061791_0_0_0"/>
    <dbReference type="OMA" id="VIRPVGM"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="229"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="31800" checksum="E2CA6003C2F7AF5C" modified="2011-04-05" version="1">MADTVQMPPQNEEDQLQHRRDPNSDPESAAYAPPAPPVAQRPVFGASLTEMEVKRDPKSAAISTVVNVVIIAFFLWFAARKSGLIAPPAVQNITLVEPPPPPPKAPPKAVQMGGGGGSKGPTPVVHGNPPKFAPVVLNPPKAPPLEQPKIQVPVTVNVQQDLKMAHVDSPAIGMPNSPIIGVTSGGGGSGGGLGSGNGNGLGPGSGGNTGGGLERIGGSVSAPVVLYQPEPEFSEEARKAKVAGNVLVYLQVDTNGKPQHVRVLRGIGLGLDEKAVEAVRNYKFKPAMKGGHPVAVEMNVEVNFQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX28</accession>
    <name>E8WX28_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1536</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1536"/>
    <dbReference type="EnsemblBacteria" id="ADW68589">
        <property type="protein sequence ID" value="ADW68589"/>
        <property type="gene ID" value="AciX9_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1536"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074041_0_0_0"/>
    <dbReference type="OMA" id="DDTLWVN"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="235" mass="26677" checksum="B892E71E46BA5AF4" modified="2011-04-05" version="1">MKTILRSGQTLLFDADDTLWENNIYFERAIASFISYLDHRVHTMDEVREHLNRTERATIAAHGYGLKSFRKSLVTCFEQLTAARVTPEQHERIVSFANSINEQEIELLPGVQATLANLQGRHRLLLVTKGDHDEQIDKLKRSGLESYFSGTEVLAEKHESAYRALAERHGCEAETTWMIGNSPKSDVNPALAAGLNAIFIPHDFTWVLEHEVVNRPGAHQSLLELGTFEEILEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX35</accession>
    <name>E8WX35_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580992.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2652"/>
    <dbReference type="EnsemblBacteria" id="ADW69677">
        <property type="protein sequence ID" value="ADW69677"/>
        <property type="gene ID" value="AciX9_2652"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2652"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333674_0_0_0"/>
    <dbReference type="OMA" id="IDHDQAF"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="142"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="887" mass="96548" checksum="883AFFD11EA96A9C" modified="2011-04-05" version="1">MQRFQFSRFTSTTYALGIIPGLFTALALGQSSSGTVNGVVKDPMGAALPGAVVVLENPVSGYTRTAKADETGQFRFYNVPFNPYRLSVTSGGFALAAQNIEVESALPLMIPISLRVAGSATSVTVETSPDLLENDPHFHTDIDRSTIERLPVESPSSELSSIVTELSPGVAADSNGLLHGLGDHNEVSFSIDGQPITDQQSKVFSNQVPAAAIQSLEVIEGAPPAEYGDKTSLVIVGTTRSGQGVSRPTGTVSLSYGSFGTSNIGVDLAYGTKNFGNFFAANVLESGRFLDAPEFAVYHDKGNEENLFDRVDFQLSPVSSIHTNLQYTRSWFQTPNSYDTQLGYFQNGMTPGATDQRSKIETFDIAPTYTRLISDTTVFNFAPYIRRDAYNYYPSNNMLADLGPIQQEAVAQQRSLTNAGVHSDISYVKGHQNIKFGGMYEQTFLRENDQIGLVDPTLNDPAGANFNPVLAPYDLTRGGTTYAYHGQTDVKQLALYGQDQITAGHWLFNLGLRGDFYNGLSVQRQAEPRVGISYNIKQTGTVLRVSYARTQETPFNENLVLSSQGCLNPVIQAVFLTLGPCNPAPFNPGFRNEFHAGLQQSIGHHFVFSGDYITKYTHNAYDFSVLGATPITFPIEWHNSKIPGFSLSGTLTEVKGLTARVTMSSVAARFFNPQIGGVGATVGAPGGFPFRIDHDERFNQTTHLEYKMPFRKSLYYSFNWKFDSGLVAGSTPCYNVTDPNSACGGYSFDANGNPLTLNGKPAIDLSSLTADEEFQAGLVCDGVHATQINGFSICDAAGLTSKLINIPAPGTEDDDHHPQRIANRNLFDMQMGDDQIIRFGGDRYRIGARLTAINVTNKYALYNFLSTFSGTHYVSPRTITGEIAFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX46</accession>
    <name>E8WX46_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2664</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581003.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2664"/>
    <dbReference type="EnsemblBacteria" id="ADW69688">
        <property type="protein sequence ID" value="ADW69688"/>
        <property type="gene ID" value="AciX9_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2664"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495997_0_0_0"/>
    <dbReference type="OMA" id="TIAFKVI"/>
    <dbReference type="OrthoDB" id="1242971at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017549">
        <property type="entry name" value="APMV_L690"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03118">
        <property type="entry name" value="PEPCTERM_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230395" evidence="2">
        <location>
            <begin position="41"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="550" mass="54603" checksum="3C0EB03E3F948CE6" modified="2011-04-05" version="1">MSSLRVTRALAAIKSFATVATLSALSVAAPAMLHAQTAGAFKVTNLLSDGSVAATTMDPNFINPWGISVSPTWWISAQGTGFNYVTAAAGTIAFKVIVPAAAGGTATGTPTGSVTTAGTTGMILPNGTKASFIFSSIDGAITGWNSKLGTANAISQVAATGATGSVYTGLAVFTNAAGASFLLAPNFGTGKVDIYDSTFKPATLAGTFTDPSLPTGYFPFSVHVIGTQVFVAYSQRTAAGLELVAPGNGVVSIFDLTGTFVARAVTGGNLNAPWGVAIAPASFGIFSKDLLVGNFGDGLINVYDPKTFAYLGQLIDGTGKPLAYASLWDLLPGGTAIPGGTTVSAGDPSTVFFTAGLAGEKHGLLAGIANDATTAGTPSFGVSTSSSALAVTAGSNVQATIAVAPTYNFSGTVTLACSGLPVGASCTFGPTQLTVAGTASSTGTVTILTSKANAALVRPASKLTTGLAFAMLLPFASLLAFRKRKATAGRSVLPNLLGVLLLLVSIGSLAGCNDSSSTPAVVTPAGQSTIAVTATSGTISQTTNVALTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX57</accession>
    <name>E8WX57_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2675</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581014.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2675"/>
    <dbReference type="EnsemblBacteria" id="ADW69699">
        <property type="protein sequence ID" value="ADW69699"/>
        <property type="gene ID" value="AciX9_2675"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2675"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_0"/>
    <dbReference type="OMA" id="ACFSVAF"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="416" mass="44102" checksum="1CFC6A7F4B489F6F" modified="2011-04-05" version="1">MMRSNSRSTTLIFLIVFLDAMGIGIVFPVLPGLLRSLLHGQGLHGPGDVVRQYGYLLAAYAATMLLASPVLGALSDRFGRRPILLLSLMGTAVDDLVMALSPTVWVLYVGRAVAGLTGANMTVANAYLADINSAETRAAAFGRMNAFFGVGFIAGPVLGGLCGTYSLRAPFYVAAGLNLIGFLVCALVLPESLVARAAVRPRITLAQLNPFAAMRAISGLHGVGRLLYMFCTIDLVGQVPAVLWVLYTTGRFQWTPTVVGISFAYFGLFHALCQAFLPERLQKRWGERGTLMIGMTADSVGMVLFSLARSTAAVFGMIPLLCLGGVSLPALQSLLSNSVGDERQGEMQGVLTSFNGLIAVTGPVLASGVYGLLRERVPSYPGAVWLVPVMLYLPCFLMVAVGGKLGRRASVTTDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE8</accession>
    <name>E8WXE8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0409"/>
    <dbReference type="EnsemblBacteria" id="ADW67481">
        <property type="protein sequence ID" value="ADW67481"/>
        <property type="gene ID" value="AciX9_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0409"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_4_1_0"/>
    <dbReference type="OMA" id="AGFRWHK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="102"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="39471" checksum="89D3A3E4AF14A213" modified="2011-04-05" version="1">MPPVLPMLAKRVAAIPEGEGWVFEPKWDGFRVLVFRDGDEILLQSRDTKPLNRYFPDVVETLLRELPPRCVLDGEIVIARDGGLDFDALQLRVHPAASRVKMLAEQTPASVVFFDLLCVGDEDLTGAPFSERRKRLEEVLAGAKVPVHITPATQDHAVASDWFERFEGAGLDGVMAKLLGGTYQADKRVMLKVKHERDCDCVVAGFRWHKDGPGTLVGSLLLGLYDDAGALQHVGVCASFTAAKRKELVEFLAPYREGAMEGHPWAGWAEADVEGRMPGGKSRWTGSKDLSWVALRPVLVVEVAYEHMQGMRFRHMSQFRRWRTDKAPKDCTYAQLEVVAAQELMEIFRESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXF0</accession>
    <name>E8WXF0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0411</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578811.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0411"/>
    <dbReference type="EnsemblBacteria" id="ADW67483">
        <property type="protein sequence ID" value="ADW67483"/>
        <property type="gene ID" value="AciX9_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0411"/>
    <dbReference type="HOGENOM" id="CLU_2617040_0_0_0"/>
    <dbReference type="OMA" id="PINTFTH"/>
    <dbReference type="OrthoDB" id="10285at57723"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8140" checksum="6798088F9B11C4B8" modified="2011-04-05" version="1">MADTESGALTLAKHEGLGSVTVCNCGVVSLHIGGVTVRLEMAAFAGLESMVHKAMNELSLQAITARSTQLTPINTFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXL2</accession>
    <name>E8WXL2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1575</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1575"/>
    <dbReference type="EnsemblBacteria" id="ADW68628">
        <property type="protein sequence ID" value="ADW68628"/>
        <property type="gene ID" value="AciX9_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1575"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068226_2_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="2">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23637" checksum="9310EF14E37908FF" modified="2011-04-05" version="1">MRPTREVATNNGQTYFVTSNSAGRQCFFRNERWADLFTASLLSYRPDRFALHAFTVMPDHFHALLTPRDSLERAVQFIKGGFSFRAKKELGWNGDVWVAGFSDHRIRDVADCDVHIQYIERNAVKAGIVSRAEEYLYCSASGRFELDELPRGLKPGFVVGLDGGAKALPFQSNGQSNSSSQSKSNGRSNSSSQSNGNNMDGGMDVAPLERKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP0</accession>
    <name>E8WXP0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579975.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1603"/>
    <dbReference type="EnsemblBacteria" id="ADW68656">
        <property type="protein sequence ID" value="ADW68656"/>
        <property type="gene ID" value="AciX9_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1603"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_0"/>
    <dbReference type="OMA" id="QIWRGRI"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="13505" checksum="A7E9EDC150A8917D" modified="2011-04-05" version="1">MVVDQLGTAFAALSDPTRRAMIERLSQGPASVHGLTEPFALSQQMISKHIAYLVRARLVVKTKRGRESVCTLRPEAIKTVSEWAMNYRRFWEESFDKLDVVLNQMKKEEAGHDTKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU0</accession>
    <name>E8WXU0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2761</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2761"/>
    <dbReference type="EnsemblBacteria" id="ADW69785">
        <property type="protein sequence ID" value="ADW69785"/>
        <property type="gene ID" value="AciX9_2761"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2761"/>
    <dbReference type="HOGENOM" id="CLU_1658356_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230053" evidence="1">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17325" checksum="FEBAE505EEECDE27" modified="2011-04-05" version="1">MIHKSTKIACSVMTLLLSCIAVPNLHAQGAYNPSAPKPLQLTTAKSVFISNNTAAPLANSDKVFDEIYAGVKQLNRFTVLASPEAADLILEFSLITTGDNDQFVTLRILDGKTRIVLWSVSDSGQTKAIYGSNGKKNQHDVLDNIFDYLQIITTPKQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY12</accession>
    <name>E8WY12_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0479</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578879.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0479"/>
    <dbReference type="EnsemblBacteria" id="ADW67551">
        <property type="protein sequence ID" value="ADW67551"/>
        <property type="gene ID" value="AciX9_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0479"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_3_1_0"/>
    <dbReference type="OMA" id="APWRDNF"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29273" checksum="A6806D966C350536" modified="2011-04-05" version="1">MPRSKSSESASPKPGLFPETPPTTPNLFAGTSGWAYPTWKPGFYPAKTSAKNFLGFYASQLNSVEVNFTFRKLPTEAQLNGWLAQTGEGFRFSFKAPQRITHFSRLRDCHEQLTEFIAALKPAADAGKLGLLLFQLPPNFKADPARLATFLADPALIGAPPIAFEFRHESWFSDEIYAVLRAHNAALCIAETDDLNTPEVHTSATHTSFRLRRAGGYSPEELAVFAIRFKALAKDRQVYAYFKHEDEPTGALNATAFLALASGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY89</accession>
    <name>E8WY89_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1666</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1666"/>
    <dbReference type="EnsemblBacteria" id="ADW68716">
        <property type="protein sequence ID" value="ADW68716"/>
        <property type="gene ID" value="AciX9_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1666"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="MPISMQV"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="158"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="460" mass="50905" checksum="C2B9A380A79BDA36" modified="2011-04-05" version="1">MTIPSKPNPRCRLLIADDQPHILDALDLLLRPEGYELVTAQTPAEALLRLAESEFDGLLIDLNYTRDTTSGQEGLDLIAAIRQSEAHLPVIVMTAWANVDLAVEAMRRGASDFVQKPWDNQRLLSVVRTQTEFFQLQRRAQRLEAENSLLRAEGAPNFIATAAAMHPVVELMARIGPSDANVLITGEHGTGKEVVAQTLHRLSHRASQSLIAVNTGALSDGTFESELFGHVKGAFTDARADRIGRFELASGGTLFLDEIANIPTRQQAKLLRVLETGELERVGSSTTRKVDVRMLSATNADLHAAAIDGSFREDLLFRLNTVEIRLPSLRERREDIPLLAAHFLNRYAARYRRQLSGFEPAALNVMLNYGWPGNVRELDHMMERAVLMARGTQLSVSDLGIQAHAVRSSLQTLDDLSLETVEALLIRKALTRTNGNVSHAAEALGLSRGALYRRMEKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY98</accession>
    <name>E8WY98_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1675</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1675"/>
    <dbReference type="EnsemblBacteria" id="ADW68725">
        <property type="protein sequence ID" value="ADW68725"/>
        <property type="gene ID" value="AciX9_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1675"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_0_1_0"/>
    <dbReference type="OMA" id="DTTETIH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046278">
        <property type="term" value="P:3,4-dihydroxybenzoate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012794">
        <property type="entry name" value="PcaR_PcaU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02431">
        <property type="entry name" value="pcaR_pcaU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="105"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="31455" checksum="B729CCA1F4152AD3" modified="2011-04-05" version="1">MPLSSRLAPPPALGKDAPAAPPAAPRPTPASSLDIYQGDPNFMTSLARGLIVIQAFTQQSPQMTISQLSVKTGLSRAAVRRCLYTLTKLGFAGAEDGQRYSLRPRMLSLSHTYTTSSTLSTSAQPVLERMSSTFRESFSVATLDGDDIVYIARTQVASRVMAVDLHIGSRLPAYCTSMGRVLLAYLPPDQLEQYLARVDLIPHTTRTITTVDKLRLALRSVRRLGYALVDQELEVGLRSLAVPVYAPNGRVVATVNLSGNAPRLPVFDMQTHFLTPLRNAATEIGSFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYP3</accession>
    <name>E8WYP3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0570</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0570"/>
    <dbReference type="EnsemblBacteria" id="ADW67641">
        <property type="protein sequence ID" value="ADW67641"/>
        <property type="gene ID" value="AciX9_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0570"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_2_0"/>
    <dbReference type="OMA" id="CVMCDIW"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="352" mass="38707" checksum="3A85D419610DA80C" modified="2011-04-05" version="1">MSQLYEIQPAPITSPAVLDSARISHLPILLLNVHTQCNCRCVMCDIWQRKDSRTMTAAEVTRHLDSFHALGVRQVVLTGGEPLLNPALAAICDLLHTLDIRITLLTTGLLLRNKAALIAAGIDDVILSIDGPPEIHNHIRRVPRAFEVIAQGVEAVRLLRPSIPITCRTTVQKQNHMHLRAAVQAAHSLALDSISFLPADVQSTAFNREQPWEAERKDEIGLNHAEVLSLEQEIEALIHEHQADIQARFIVESEAKLRRLATRFRERLEATPPRAPICNAPWVSAVMEVDGRIRPCFFHAPIGSASSGALEDALNSPAALAFRSQLDVAANPICQRCVCSLNYRAPQGAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ89</accession>
    <name>E8WZ89_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-sulfur cluster binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0620</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579019.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0620"/>
    <dbReference type="EnsemblBacteria" id="ADW67691">
        <property type="protein sequence ID" value="ADW67691"/>
        <property type="gene ID" value="AciX9_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0620"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027059_1_0_0"/>
    <dbReference type="OMA" id="HCPVYDK"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00273">
        <property type="entry name" value="TIGR00273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="492" mass="54344" checksum="1F17AD0A959D50FA" modified="2011-04-05" version="1">MSGTALDPRTAPIFPMAAHKLLGDSQLRKNVRHATDVIQNKRRIVVGEMPDWEALRESGKQLRAHTMQHLGHYLQQFERNCIAAGGQVHWARDAAEARQIVVDLAQSAKAKEVIKIKSMTTEEIFLNPALKAAGIQPFETDLAELIIQLGGDQPSHIVVPALHKNRAQIREIFMREMNLPNLGHTPQDLADAARLYLRQKFLTIHTAVSGANFLIAETGGVCVVESEGNGRMCLTLPKTLITIAGIDKVIPRFQDLEVLLQLLPRSATGERMNPYNSVWTGVTPGDGPKNFHVILLDNARTEILADHEGRQTLNCIRCGACQNACPVYRQTGGHAYGSVYAGPIGAILTPQLQHMEHAQSLPYASSLCGACYEVCPVKINIPEVLIHLRNKVVKQNGALTPEALAMRTMGMIFRSESRFRAAQRFGRIAETPLVRKDGQGQGWIGWLPGLLGGWTQVRDLQSMPKQTFREWFENRPQSTGKPAPKKGGTDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH3</accession>
    <name>E8WZH3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1813</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580180.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1813"/>
    <dbReference type="EnsemblBacteria" id="ADW68861">
        <property type="protein sequence ID" value="ADW68861"/>
        <property type="gene ID" value="AciX9_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1813"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046101_1_0_0"/>
    <dbReference type="OMA" id="EMPRKYW"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023875">
        <property type="entry name" value="DNA_metab_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025404">
        <property type="entry name" value="DUF4130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13566">
        <property type="entry name" value="DUF4130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03915">
        <property type="entry name" value="SAM_7_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="352"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="521" mass="58629" checksum="22CD7616F19D8ED7" modified="2011-04-05" version="1">MKRLLIDPDFEAWRITAREQLHAGYHPDQLDLQDATAPTSLTLALEADEPPTGPPLPRPTISKSFLEAAGYVAVHRDPQRWNLLYRILFRLQSNRNLLALETDDDIIQLTRLESQVKRDLHKMHAFVRFRKVLEPSDPSERPTVLDEPIPIDPDPHAHHLVLETPTPFGPIKTELESCPPEDITPDADCEHFIAWYQPDHRILPLAAPFFAERFAIMHWTILTPDASAVWDPITKQLTFAPGVPRESAPAEDELEGLWRSYYASIFNPARLNPAAMKSEMPVRYWKNLPELTLLPTLITQSKTRVQNMVQRQQSQPTAQPFVPDHHTIRAIAEALPTCKGCELYCHATQVVPGRGPATAALMLVGEQPGDQEDLQGEPFIGPAGAVLDHILEDLRIPRKEVYVTNAVKHFKFVQRGKLRLHQSPRMSEIMACRPWLLAEIDAIKPKVVLCLGASASKSLLGGTFALMKDHGKLNSTPFADKVFATIHPSAVLRARDEPNRQQLQQFLTDDLAKAWQATIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZL4</accession>
    <name>E8WZL4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ordered locus">AciX9_2965</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2965"/>
    <dbReference type="EnsemblBacteria" id="ADW69988">
        <property type="protein sequence ID" value="ADW69988"/>
        <property type="gene ID" value="AciX9_2965"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2965"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816189_0_0_0"/>
    <dbReference type="OMA" id="RWNAVIT"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="277" mass="29439" checksum="E42D7BC80A31862D" modified="2011-04-05" version="1">MTVVRAVGASEEFVRLSELFAALGFEAGKGWEDDGGKGAAFLAPVGNLELVTGRMPGSPEMLIEVSELDHVHAAVTKWMDGKAGLSGVEATHWNSRMFTVHLGTGLTLGFWQSENPLHGVVPAVEGDLSAVGMKFAIVTTRWNTVITNRLLQGSLDCLYRSGAKREDVTVVRVPGAWEIPNAARTLAESGKHDAIVTLGCLLRGETAHYEAIYNEVARGIGQSQQETGVPHAFGVLTCETLEQALDRAGLKAGNKGFEAASAAIEMVSIQRKLKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN8</accession>
    <name>E8WZN8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dihydrodipicolinate reductase</fullName>
            <ecNumber evidence="10">1.17.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2989</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581326.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2989"/>
    <dbReference type="EnsemblBacteria" id="ADW70012">
        <property type="protein sequence ID" value="ADW70012"/>
        <property type="gene ID" value="AciX9_2989"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2989"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_1_0_0"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="9">
        <location>
            <begin position="108"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="24440" checksum="483749B2433C29ED" modified="2011-04-05" version="1">MRVLVLGHGKTGKLVAQIAAEHGHSVHVLDAKENPNAQALTAPFVAGFDVVIDFTTPEAAIQNMRACLATGAKMVIGTTGWYDKLADMKSLAERREGSLLYGTNFSVGVQVMLKVAYEMGAALKDAGFKFSINETHHASKLDAPSGTALTLCETIQTSSGAVDVGITSSREGDETGIHILTAQSDSDRITLQHESFSRSGFAEGAVRAAEWLSTRKGTYDFRDIFDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP8</accession>
    <name>E8WZP8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2999</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581336.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70022">
        <property type="protein sequence ID" value="ADW70022"/>
        <property type="gene ID" value="AciX9_2999"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2999"/>
    <dbReference type="eggNOG" id="ENOG5033UZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962292_0_0_0"/>
    <dbReference type="OMA" id="MCRISTS"/>
    <dbReference type="OrthoDB" id="1722455at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233534" evidence="2">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="289" mass="30677" checksum="43844E54C30B84EA" modified="2011-04-05" version="1">MKGPHLILSPGVAALLLASLSATAARGQSPLLSRLTLPDAPSSSSVWTSQSQDAAKPQPSAETDAQRRERIRKQSADQVAAEEKQRIAGVVPDFNVVLGGYAPPISPAQKFSLVFHSSIDPFTISLAAVLGGYDEISGSHNGYGWGPAGYFKRFGAQYADTVDGAFWGNAVLPILLHQDPRYFRKGTGSIKSRILHSALSTVICHGDNGHSQFSISNIAGNIISGGISNLYYPSNERGIGLAFDNALQVTAEGAFGAQLLEFSPDLVALYHRHQQRVQDKKAAAAAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ1</accession>
    <name>E8WZQ1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ordered locus">AciX9_3002</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3002"/>
    <dbReference type="EnsemblBacteria" id="ADW70025">
        <property type="protein sequence ID" value="ADW70025"/>
        <property type="gene ID" value="AciX9_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3002"/>
    <dbReference type="eggNOG" id="COG1054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038878_0_1_0"/>
    <dbReference type="OMA" id="CDTHTNC"/>
    <dbReference type="OrthoDB" id="684577at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="136"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27856" checksum="5F81793E2C89ED8D" modified="2011-04-05" version="1">MTNKKARGSVFDNGGMVYTIAAFYRFVAVADPAGLREEMAGLFTEEELWGTMLIAGEGVNGTMAGEAGTISRLIETLGAKVGLEAGDVKFSYADERPFGRLKIKVKDEIIAFRKAVVDPSQAGTYVEARDWNALIADPEVLVLDTRNKYEYEAGTFAAAVDPGIENFSEFATFVKERLDPERHKRVAMFCTGGIRCEKASAFMLQEGFGEVYHLKGGILKYLEEVPEAESRWSGDCFVFDRRRGVGHEDFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ3</accession>
    <name>E8WZQ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3004</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581341.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3004"/>
    <dbReference type="EnsemblBacteria" id="ADW70027">
        <property type="protein sequence ID" value="ADW70027"/>
        <property type="gene ID" value="AciX9_3004"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3004"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719168_0_0_0"/>
    <dbReference type="OrthoDB" id="1446160at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230494" evidence="1">
        <location>
            <begin position="25"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="42659" checksum="7955B3AF58EC831B" modified="2011-04-05" version="1">MKRHPHCTTCLQLFLPLLLLFLHASPSFPQAPRARVIVFVHGLHGDRSSWRAANGAYWPDLVKSDPHFALSDVDVVEYPSPASNGKSSSIQLADILWNRLKQDHVWDHREVVFLAHSLGGILVEEMLLRHPAEAARVKFVVSYGTPHEGSTVARFASIYDKDPILNDLSDATSNTFLTNLESSWRGTPTVNSIHRFCAYESEDTTPEDGIARYLKPHTRVVSYFSATYGCDVTTPPQEIHADHIHMIKPLDRNSAAYDFFRRVYRDNPILEEQIVTRDNVIAGLTAGCGQANSNVDLQVPIALDSTFHERVTAVTASLVNMTDVHDIDPDPPIVTGIDPSGVAHIDYGFKGPGKTLLVCLGTARASLKVQFTINRQIPIREPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X006</accession>
    <name>E8X006_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1856</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580221.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1856"/>
    <dbReference type="EnsemblBacteria" id="ADW68902">
        <property type="protein sequence ID" value="ADW68902"/>
        <property type="gene ID" value="AciX9_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1856"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_3_2_0"/>
    <dbReference type="OMA" id="HRYHNPL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="455" mass="50170" checksum="67CDF32DD21FAF04" modified="2011-04-05" version="1">MEEIVDDVIVVEAPQIEMASLESKALNATLWTILSYGAAQGLRVVNSLVLTRLLLPEAFGELSLVMTLIVGMTLLSDLGLEPSIIQSKHGDEPLFLNTAWTLQAMRGCVLWLVAVALAWPAAKFYHDPQLVYVLPVLALTTILNGFNSVGLFTLARHMGVRRLFALDFSTQILTLAVTVTWAYYRPSVWALVVGSLFAATYRLVLSHQKKIVPGVRNRLCWDKASIHEIVRFGKWIVLGTAFFFFASQADRLILGKLVSLTMLGIYLIAFQISDIPRSVIGALSSQVGYPFVAKIIHLPMAEFRAQFLKYRAYGLLIGAALLAAMIVWGNLLILKLYPVRYHEGAWIIPVLAAGLWHTMLYNTTRPVLFSLGKSSYNAYGNAAYCVAILAGIPVAYHFYGLVGAVVAVAAGDLPLYVVTQFGATREGMKPLWQDLQLTIALLGMIAIFFGLRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X021</accession>
    <name>E8X021_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1871</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1871"/>
    <dbReference type="EnsemblBacteria" id="ADW68917">
        <property type="protein sequence ID" value="ADW68917"/>
        <property type="gene ID" value="AciX9_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1871"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057011_2_0_0"/>
    <dbReference type="OMA" id="RYWTCKE"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="28373" checksum="15FC48CDB052FEE3" modified="2011-04-05" version="1">MGEMESKSATHSDPSWARPERAVALEADEIQLWRVHAEASGRLYDRCRDLLTADEVERLKRLRPGMAADEFVVGRGSLRMLLGAALRQSPREIVLQTGAHGKPFTPGIEFSVSHSRGLILIALSWSATLGVDVEAIDPTIEALEIARDTFAASEIAVIEKAQEGAERVQVFYRWWARKEAVAKAHGQGITLSLKEFAVDVDAEEEREIFLSAESNPTNRCFFVRGISLPIGFAGALAAGESNLPLRCFDLERTALLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X029</accession>
    <name>E8X029_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1879</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580244.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1879"/>
    <dbReference type="EnsemblBacteria" id="ADW68925">
        <property type="protein sequence ID" value="ADW68925"/>
        <property type="gene ID" value="AciX9_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1879"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_0"/>
    <dbReference type="OMA" id="LDYIAPK"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="49"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="471" mass="49645" checksum="7F92EF23B88C144D" modified="2011-04-05" version="1">MSFKKIAIIVVVVLALAGIATFSILQSQANVVKVTTATVGRQDLISVVTGTGQIKPKTYVNIGATAFGRITHLNVKEGDHVKKGATLATVENIQPTATVAAQQATIASSKTNVTADVAAEQTAHANIAAARADLEQRKLDYDRALELYNDKLIAKQDFDAKKAVYDASVATLDQRIASESQARAQTNSQRAMVNQAVASQRSNFDALDKTVSRAPFDGLVTNVPVREGETMVIGIQNAEGSTLMTLADMSVITAEVKVDETDIVNVAMNQTAEITVDALPGRIFKGHVTEVGDQALLRTTGVATSQSTTGTEEAKDFKVVVTIDNVDGQNNDELRPGLSTTAKITTARRPDAITIPIQALVQRDPAAEKALSASAGKPHAPSATATPAASHAKPNLVQGLYLLTTDHGKHRVTFTPVSTGVTGATDIEVLSGIKTGDIIVTGQYKVLRTLKSGTLVKIDNTPDTLADTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X075</accession>
    <name>E8X075_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpE</name>
        <name evidence="14" type="ordered locus">AciX9_3036</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581370.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3036"/>
    <dbReference type="EnsemblBacteria" id="ADW70056">
        <property type="protein sequence ID" value="ADW70056"/>
        <property type="gene ID" value="AciX9_3036"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3036"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_0"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="224"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="55148" checksum="EC03AA38879463E1" modified="2011-04-05" version="1">MRSRHESFPPRAAFEKLAKSHTLVPVYRTVTADLETPVSAFLRIANDAPEAFLLESVEGGEHVGRYTFIGIDPYKKMVAHGRRMSVSEGRRRKTFDGDVFEELKKALSGHKPARLAGLPPFTAGAVGFFSYDVVRLIERLPELAADELGVPDACLMFFDQVLAFDHVKKEILLIATVDLTRGGSYAQAEKRLDKMEKRLASALPVMKRRKPITGKLKMVPRTSKKAFLKAVNKAKEYITAGDVFQCVLSQRFDCVPEVPAFEVYRALRIVNPSPYMYFMRFGMEDSEAHIVGSSPELLVRVHDRNVEYRPIAGTRKRSADEVEDRALEADLRADAKEVAEHIMLVDLGRNDVGRVSEFGSVRVKDLMFVERYSHVMHLVSAIEGKLKPELEAIDAFKACFPAGTLSGAPKIRAMEIIEELEPARRGVYGGSIFYADFSGNLDSCIAIRTLFMNGEQGHVQAGAGIVADSVPEMEFEECGNKARAVVRAMERARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X086</accession>
    <name>E8X086_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3047</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581381.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3047"/>
    <dbReference type="EnsemblBacteria" id="ADW70067">
        <property type="protein sequence ID" value="ADW70067"/>
        <property type="gene ID" value="AciX9_3047"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3047"/>
    <dbReference type="eggNOG" id="ENOG5030GB5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1834199_0_0_0"/>
    <dbReference type="OMA" id="GYDNGRE"/>
    <dbReference type="OrthoDB" id="1543110at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="160" mass="17704" checksum="EC994960C5292155" modified="2011-04-05" version="1">MYEDFTVTDRWTSEPLHCTWKGTVVAIATRHADATDIRFAVNGRACWIAMPNIAWVEMKKSTGFVITDYLAAQAAGRYLKTCIENGYDNGREMYTMTVEEVMEHANAVVHEAGSTDKLPSLPVISDDIKPEQFLGELPGDPGSAAYFGAAQPNENDRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0A7</accession>
    <name>E8X0A7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ordered locus">AciX9_3068</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581402.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3068"/>
    <dbReference type="EnsemblBacteria" id="ADW70088">
        <property type="protein sequence ID" value="ADW70088"/>
        <property type="gene ID" value="AciX9_3068"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3068"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_0"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="256" mass="26504" checksum="0C1518AE3690B78E" modified="2011-04-05" version="1">MLTKRIIACLDVRGGRVVKGIQFVDIIDAGDPAELAHRHAAAGADEIVLLDITATHEGRGTLIDTVKRTAAALFVPFTVGGGIRSAEDAAAVFDAGADKVSINSSAIARPELIGEIGGSFGAQAVIVAIDARRGTLGVEDAEVYVSGGRKPTGLRVVDWAREAEQRGAGEILLTSMNTDGMRNGFDCELTARVSEAVQIPVIASGGAGSAAHFAEVFARGKADAALAASIFHFGVTDSRELKAELQRAGVSVRLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C7</accession>
    <name>E8X0C7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3088</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581422.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3088"/>
    <dbReference type="EnsemblBacteria" id="ADW70108">
        <property type="protein sequence ID" value="ADW70108"/>
        <property type="gene ID" value="AciX9_3088"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3088"/>
    <dbReference type="HOGENOM" id="CLU_2716764_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="72" mass="7489" checksum="2F53B93F88BBF068" modified="2011-04-05" version="1">MPESSGINMEFEQIGMVALIGLALVPGMIWVSKAKTGTRMALRTSLVTGLIVGLVALEASLDKTAESVAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0G1</accession>
    <name>E8X0G1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0756</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579151.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67825">
        <property type="protein sequence ID" value="ADW67825"/>
        <property type="gene ID" value="AciX9_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0756"/>
    <dbReference type="eggNOG" id="ENOG502ZBY4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564900_0_0_0"/>
    <dbReference type="OMA" id="WAYSTIV"/>
    <dbReference type="OrthoDB" id="776637at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="524" mass="56787" checksum="67F8EC70D9966147" modified="2011-04-05" version="1">MRLPIPDRFPPKQVILFAVCLFVAQVLEGTSLTFALLLFVYVLLAGLAFNLAGGIAYPSGAWIFFTATLTCLIGFTYKVLLGQPGESHLRAPLVTMSAYCIGMAGMAAAAYVCTAIRPREGLLANLVVGERMKQAAIGCFIFGTIGTFASLATNTADSVGAATSSGVTTAFAQLNHFVQMAIILGTTYQIAHSKGKSSTNWIVWCAGLLLFFFGVASYSKEGMFVSLLSWLVPCIAMRFDFSKKQLISGVCVLVFMFYYLVPFSQYGRRSRGDAQGLLASALIAGQYLTHLEETRKLYLEAPDVTDLGDQPHLYDTSEGFFDRLQMIAWDDLLIDYTQTNQTIGFGAIGDSFLNVIPHFIWANKPVYGQANLYGRQLGFLSEDDTTTGISFSPVGDGFYQGSWIGVGFVLPLLMLFMFLVADSLSGDVRKAPWGLLFIAISAHYAPEGMLVGVVWMATLGAEVIIFSALLSAYVLPRIIILLSGGEKTRVRATQNFVLGAPVRGVMNRNAPPLRPEPGSNAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M3</accession>
    <name>E8X0M3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ordered locus">AciX9_1928</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580293.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1928"/>
    <dbReference type="EnsemblBacteria" id="ADW68974">
        <property type="protein sequence ID" value="ADW68974"/>
        <property type="gene ID" value="AciX9_1928"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1928"/>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_0"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="338375at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="3"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="81"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="534" mass="58580" checksum="9C20642B4101EEB7" modified="2011-04-05" version="1">MPKPIILTILDGWGYRAETHGNAIAQARKPTYDRLLREYPNTLLRASEHFVGLPDGQMGNSEVGHLNLGAGRIVRMDMTRIDTAIMDGSFFTDPTLLRAMQLAQQKGRALHFIGLLSDGGVHSHQRHLYALLKLAKQQGLTNVFIHAFMDGRDTMPSSGLGHLEALQQQFREIGIGQLASVSGRYYAMDRDLRWEKSKQAFDAMVTGTPEGGQYADAAARIRELYSNGTTDEFTPPFTVTGADGKPVGLIQDEDVVINFNYRADRVRQITRVLARTSGLNQSMGRDLPKAAELDEAIPLHTLPQRIHYVCMTQYEKNYKLPIVIPAESMDNLLANVMGVANLRNLRVAETEKYAHVTYFFNGGIEKPFPGEERELVASQKVATYDLAPEMSAPGIADTVIKALTDTAFDVIIVNFANADMVGHSGKMEPTIRAVETVDAQLGRIYQAIKQHGGSMLITADHGNAEMLIDPASGGPHTAHTTNPVPFILVSDEKNITVREGGSLRDLSPTLLSLLNVSQPDQMTGGNLINSFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q0</accession>
    <name>E8X0Q0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1955</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580320.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1955"/>
    <dbReference type="EnsemblBacteria" id="ADW69001">
        <property type="protein sequence ID" value="ADW69001"/>
        <property type="gene ID" value="AciX9_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1955"/>
    <dbReference type="HOGENOM" id="CLU_2633123_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="77" mass="8635" checksum="D147B134A88F325B" modified="2011-04-05" version="1">MALVVTPYCLTCDICGEEIAVPRNAARNGEALMLFAEATAIRHNLKHAKTKLIQIKPKTICWADLVKPFRDELERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0R2</accession>
    <name>E8X0R2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1967</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580332.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1967"/>
    <dbReference type="EnsemblBacteria" id="ADW69013">
        <property type="protein sequence ID" value="ADW69013"/>
        <property type="gene ID" value="AciX9_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1967"/>
    <dbReference type="HOGENOM" id="CLU_1935080_0_0_0"/>
    <dbReference type="OMA" id="HEINIFH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14131" checksum="9A01842AA617821A" modified="2011-04-05" version="1">MAKVAKNPALDPTLPKVELKLKGKTYHLCFTFAALATAEAALKKIGHEINIFHALDFANLGAESLAAILYAALITETPDFNLLEVPTLITMRDIPAIKQALFDAFALSMVEPDKDAKADPLENPLDLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S4</accession>
    <name>E8X0S4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Lysozyme</fullName>
            <ecNumber evidence="2 7">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1979</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 24 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580344.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1979"/>
    <dbReference type="EnsemblBacteria" id="ADW69025">
        <property type="protein sequence ID" value="ADW69025"/>
        <property type="gene ID" value="AciX9_1979"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1979"/>
    <dbReference type="eggNOG" id="COG3772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091641_4_1_0"/>
    <dbReference type="OMA" id="HLNENQY"/>
    <dbReference type="OrthoDB" id="1703032at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4 7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="16216" checksum="50B60E940B33A153" modified="2011-04-05" version="1">MYNFIYSKDGLALTESFEGVRLTAYQDQGGVWTIGYGHTGADVHSGLTITLTQAEQFLLADVRHASDTVNRLVTWAGLDQMVFDSLVDFAFNAGCGAFAGSMLLKDLNAGKLAEAAHQFEAWDHVSGQVVAGLLRRRLAEEKLFDSGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X141</accession>
    <name>E8X141_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0839</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0839"/>
    <dbReference type="EnsemblBacteria" id="ADW67907">
        <property type="protein sequence ID" value="ADW67907"/>
        <property type="gene ID" value="AciX9_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0839"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_6_0_0"/>
    <dbReference type="OMA" id="ITHLAWA"/>
    <dbReference type="OrthoDB" id="1326265at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="340" mass="36916" checksum="702401CB68BA0B84" modified="2011-04-05" version="1">MDRPKRVLVVRVGAMGDVLHGLPAVAALRERWPDCFIGWAIEPRWRALVEGGVADRVHLVPTREWKERPFSTATLRQIVELRREMRAERYDVCVDLQGSIRSAVIGRMSGAARFVGAAKPRERQARALYGERVSLRAEHVIGQACELMSAGVGVRIAQAKASLPVNAEAEEWFARTVGGEGFVVIAPTAGWGAKEWPAERFAIVAREFKARGLRVLVNSSGGDLARRVAEDGGAELVECGVAELVAVTRRAALVIGGDTGPVHLAGALGRPMVALFGPTDPARTGPYFVGAKVRVLRDAGSVVDHRRHEETEAGLMRVRVEEVVEAAFSLLETDHPEFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X144</accession>
    <name>E8X144_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0842</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579235.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0842"/>
    <dbReference type="EnsemblBacteria" id="ADW67910">
        <property type="protein sequence ID" value="ADW67910"/>
        <property type="gene ID" value="AciX9_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0842"/>
    <dbReference type="eggNOG" id="ENOG503200P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103372_0_0_0"/>
    <dbReference type="OMA" id="VNTHARD"/>
    <dbReference type="OrthoDB" id="1715776at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230151" evidence="2">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="232" mass="26181" checksum="6F5A0F4273885860" modified="2011-04-05" version="1">MTPTPKLTRSLAAALLLATPVLARAADKPRPAPPVKPAAEYPLNDPHPTEKVTIAADPCTEKADCSFFRLPYIEHGFQPVRIIITNDRDEAVILDDVRMQFIPAEGDKEAAADDEDLNRRLFNHKYAEGTKIPLIPVTIHKEPIDKKILSDDQDFGFQSTTVPPHSTRAGYVFYDTRGIDDPVLKHAELYIKRIHYVDEHTVKHELFAFTLPFDKWLAAQPKPDKKPEANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X148</accession>
    <name>E8X148_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trmFO</name>
        <name evidence="12" type="ordered locus">AciX9_0846</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579239.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0846"/>
    <dbReference type="EnsemblBacteria" id="ADW67914">
        <property type="protein sequence ID" value="ADW67914"/>
        <property type="gene ID" value="AciX9_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0846"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_0"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="446" mass="49353" checksum="C6A843B64C43C328" modified="2011-04-05" version="1">MKKIRIIGGGLAGPEAALQAAAAGCHVELYEMRPTRSTEAHQTSDFAELVCSNSLKSESENSAPWLLKQEMRRAGCVLLAEADASAVPAGHALAVDRVAFSARVAARLESNPLITIHREEVTTLNATDADLTILASGPLTSAPLAAALQQITGSEQLAFYDSISPIVDATTIDMDKVYFAARWDKGTADYINCPFTKEEYETFMDALTSAENVQAKEWEKLDYFEGCLPIEETARRGRDTLRFGPMKPAGLTNPKTGRWPYACVQLRQENLRADSYNLVGFQNHLKFGEQARVLRLIPGLEHATFLRYGQIHRNTYIHAPSLLTETLQLRARPDILIAGQLSGVEGYTESIASGMLAGQFAAALLAGRTPVPCPRLTAHGSLIHYITHAEDRGKGNRFQPANITFDLLPPLEEDLRKKIRDKKERHRIQCERALTAWQQWRTQTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E7</accession>
    <name>E8X1E7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2056"/>
    <dbReference type="EnsemblBacteria" id="ADW69101">
        <property type="protein sequence ID" value="ADW69101"/>
        <property type="gene ID" value="AciX9_2056"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2056"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_0_0"/>
    <dbReference type="OMA" id="HDSGPMH"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="367" mass="40523" checksum="A704835033A4EB8E" modified="2011-04-05" version="1">MGGMAKRVKRVLIYRLGSLGDTVVALPALHLIARAFPGAERKLLTNFPINDKAPAAAAVLGKSGLVAGYFRYTVGMRNPFALLRLWFELIRWRPQVLVYLAAARGVSVAKRDSLFFKVCGIPRQVGVPLTDVAQRNTWLGDELGYEPECERLVRNISELGDAEIDRADAWDLRLSIAERARGREMLAAAKGRPLIMFSIGTKLQANDWGKERWRALMVEMGRQYRDHALVFTGVKGESETSEFVAEGWRESAGEDSPVVNLCGKLSPRESAACFAQAQVFLGHDSGPMHLAAAIGAPVVAIFSARNLPRMWFPYGKQHRVIYHEVSCMGCGLERCVVEQKRCLTSIGVDEVVEAVREVLGERVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H6</accession>
    <name>E8X1H6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AsmA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581523.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3200"/>
    <dbReference type="EnsemblBacteria" id="ADW70211">
        <property type="protein sequence ID" value="ADW70211"/>
        <property type="gene ID" value="AciX9_3200"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3200"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489807_0_0_0"/>
    <dbReference type="OMA" id="FTITHAT"/>
    <dbReference type="OrthoDB" id="643920at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="556" mass="60068" checksum="903B285839F86E98" modified="2011-04-05" version="1">MNEQTPINDPHLDHLSDTGGDDDFGPPPFHAITHRRAIAVVLVLAVLVLLALLPPLLNVNRYKRQIVTSISTSLGRPVHIDSVSLNLLPLPSFTLENFVISEDPAFGAEPVLQANEVRANLRVSSLWRRRVEFSRIALDSPSVNLVHLPDGRWNLESILLQASRMPAAPTAQKKAGTAPRFPYIEATGARVNLKMGLEKMPISLTEADFALFLPEPNEWHLRLKTHFVRTDAPPTDTGILRVEGTLGRASTLAAVPVDLHADWETAPLGAVSWVLMGRDAGLRGEMNLTAAVTGTVGSNNLDTHLTLQRVRRADFVPEHTLDAELTCKARVGDVFHAFHNVRCAWPSGTSDGGLMVTGELPDLRNLQTAQATATFKDIPAASLLDALRVASNRVSPTLKVAGGISGTYVYTAQPTPLHEKLPAAPNFTITHATLDLGDNKPLLDQDLTGTLTGNQLTLAPIPLALAPASREPASLDLKLDEAGYTLHLSGTVLSSRLLQLAKALPQVGDGLEALLPTPLPPAPIRVDLLSNRTWGQPQTWSTAAVHPAPHGRIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1P1</accession>
    <name>E8X1P1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M1 membrane alanine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0892</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0892"/>
    <dbReference type="EnsemblBacteria" id="ADW67960">
        <property type="protein sequence ID" value="ADW67960"/>
        <property type="gene ID" value="AciX9_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0892"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_0_0_0"/>
    <dbReference type="OMA" id="EFGHNWF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234083" evidence="2">
        <location>
            <begin position="19"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="3">
        <location>
            <begin position="388"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="632" mass="70312" checksum="27AEBA1686B2D7CD" modified="2011-04-05" version="1">MKKILSGLAFLLALSSSAQTPAYDPLVTFAPLTLPDPVNAYRSANGAPGPSYWQNRADYELHASIDTAAKVLTGDEVITYTNHSPDALTSLWIQLDQNTYRKDARSAPAAGGRRGIPRTQSTDGDVLDTVEVAGQKADYVVSDTRVQVRLAAPLAHNGVAKVHIKYHFTIPEKWGGRMSWGDAKAGPIFDMAQWYPRMCVFDDLHGWDTQPYLANEFYLEYGNFDYSVTVPAAMVVAGSGELVNPKEVLTPTQLKRLDQARASDKTVMIRTLEEAAAPTGTGTKTWHFKMENTRDVAFSASAVFLWDAARMNLPGGKKSLAMSYYPAESAGEPAWGRSTEYLKDSVERFSARWFPYPWPNAINVAGPSSGMEYPGILFDGIDDKGKVLFFITAHEIGHSWFPMIVGFNERRNAWMDEGFNTFIDIFESDDFSNGVYGPKRDGEYAPGGGHPADEIAKVIADPAAPAILTRADAIKEKYRHPITYFKSAFGLTLLRDDILGPQRFDFAFRKFIADWAYKHPSPSDFFRAMESEGGEDLSYFWRGWYLNNWQLDLAVTKIDPTPTGATVTIENRGQLVLPAVVELTFEDGTKRRVTLPAETWIQKTVYPLAVETTSPLKQAIIDPDHNLPILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X252</accession>
    <name>E8X252_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3284</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581607.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3284"/>
    <dbReference type="EnsemblBacteria" id="ADW70295">
        <property type="protein sequence ID" value="ADW70295"/>
        <property type="gene ID" value="AciX9_3284"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3284"/>
    <dbReference type="HOGENOM" id="CLU_1756252_0_0_0"/>
    <dbReference type="OrthoDB" id="2044406at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16022" checksum="90C26BF4C4B65C79" modified="2011-04-05" version="1">MKEYKHIVIDKMGVGLDALRTSLNVSGLETAHSRGIQLSAGSVALEHHLHIFLWDDSIKGITGSLGIINAGNTITVKVRWDKLIESGIIFPGTLKGDTMQNKPPGGPSTNGAWAYKGNIPRNYLYIDGVDSPATHGFSTWQLGKGWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2E4</accession>
    <name>E8X2E4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RepB plasmid partition</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579399.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1012"/>
    <dbReference type="EnsemblBacteria" id="ADW68076">
        <property type="protein sequence ID" value="ADW68076"/>
        <property type="gene ID" value="AciX9_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1012"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080416_0_0_0"/>
    <dbReference type="OrthoDB" id="1630210at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011111">
        <property type="entry name" value="Plasmid_RepB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07506">
        <property type="entry name" value="RepB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RepB" evidence="2">
        <location>
            <begin position="101"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="34077" checksum="36C2C0C55996C179" modified="2011-04-05" version="1">MAAESVKIAFIQEVLEVPLESLKALKETTAIVMGCRKYKQIKASLEHIGMIEPLAVFPQKDGSYLVLNGNLRLHILRELGHTSARCIVALDDESYTYNKRVNAMSPIAEHYMILKAIANGVTEERLAVGLSIDIEAIRRRRNLLDGICPEAVDMLKDKRISHDTFSSLRKMKPLRQIEAAELMISASNYTSPFAAVILSVTKPELLEKPPKKSTRADPPHASSLLEETTDSLISDLAHVRKTYGIDVLSLTVICRCIESLIENRAVVRYLQLNHTDIFEELKRLVDQSNADRAHLAPHETSDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G9</accession>
    <name>E8X2G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver modulated metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2149</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580509.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2149"/>
    <dbReference type="EnsemblBacteria" id="ADW69193">
        <property type="protein sequence ID" value="ADW69193"/>
        <property type="gene ID" value="AciX9_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2149"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_0"/>
    <dbReference type="OMA" id="LILERQM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="154"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="40300" checksum="0A14B8E55841514C" modified="2011-04-05" version="1">MLQGRVLVVDDEAAVRGIVTALLERMEYEVVTANGVSAALNYLQGDPAFDLVMSDIMMPGVDGLALLDAVVADYPGMPVVMFTAVHDIHVATNAFRRGATDYLLKPFERSQLASVVGRAVEHGRLRKQSSAYRQNLEEIVSSRTGQLRATMQDLERSYDITLEAMGDALDLRDAETEGHSKRVTAYSIALAREMGLNAHELRVIARGAFLHDIGKISTPDSVLLKPGKLDDDETEIMREHCERGYEMVRKIPFLKEASEIVYAHQERYDGSGYPRALSGEEIPLGARIFAIADTLDAMTSDRPYRRAATFEAAQAEIARCSGIQFDPAIVRVFMAVEPERWRVLRAEVGRLSAGTASVALCRPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2L4</accession>
    <name>E8X2L4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2194</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2194"/>
    <dbReference type="EnsemblBacteria" id="ADW69238">
        <property type="protein sequence ID" value="ADW69238"/>
        <property type="gene ID" value="AciX9_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2194"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057463_0_0_0"/>
    <dbReference type="OMA" id="GAKCCTL"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="33235" checksum="716DE793AD6CD7D5" modified="2011-04-05" version="1">MFNGKETTVLAGTLAGNVAATLPSTHFSRATFLMCSPEWYDVGYVINPWMAGNLHRPTRDASFAQWRGLYEALGRIADVKLLHPRQGSPDMVFVGHTALVHHGVAAVSSFAHAERQPEERHLRRWLQEAGFLLWDTPRETCFEGEGDALFDSDGRHLWAAHGARTCKYSHGHVAEAWHVQVTSLHLVDPRFYHLDTCFAPLSGGRVLYYPGAFDAMSLALIEAAYPAERRIMATESEAAQFGCNVINIGRDVLMHKASGRLAERLRAAGYAVTELPLGEFLKGGGSAKSLALRLSDLSVTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2M9</accession>
    <name>E8X2M9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3315</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3315"/>
    <dbReference type="EnsemblBacteria" id="ADW70326">
        <property type="protein sequence ID" value="ADW70326"/>
        <property type="gene ID" value="AciX9_3315"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3315"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_0"/>
    <dbReference type="OMA" id="GFACTAI"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="94"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="374"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="500"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="882" mass="94752" checksum="B7F78440A8C23951" modified="2011-04-05" version="1">MSMMRRLGNLLSRSKVASEIDDELRSHIEMRVDDNLAAGMSPVEARRDAEIRFGNRIATKERVLGEDVVLVIESVGHDARFAMRQLVKNPGFAVTAILVLALGIGASVALFAFVDAALIKPLPYEQPTRLMEVTETAPIFGRANLSYPDFLDWKRADTDLQAFDVYRSTGFLLGVGSGAEPVSAEYVSAGFFKTLGVKPLLGRSFNAGEDKPEAPRIALLSYGTWQRRFGGRSDVVGQTVTLTDDPVIIIGVLPETFQFVPHGNAEFWLPLQVTVNSSCEKRRSCHSLKGIGRLKDGVTEAQARREFEGIATNLERQYPDSNRGQGASVISLSEAFVGDIRPILLALLGGAALLLVIACVNVASLLRVRSESRRREVSLRSALGASRGRLLRQFVIEGLLLVLAGGALGLGTAYLAVQLLLRLIPRNMLLGMPYLAGLGLNLHVLAFAAAVCGISATLFSATPLLRLVVAGGGLRGGISEGGRGSSGTIWRRFGANLVALELAIAVVLLVGAGLLGKSFFRLLHVDLGFEPDHVATLQLVLPRKQYDNDDKQRAEAQEIMNRFSALPGVKSVGLTSMLVLSGNGNTDWIRFVGRPYDGKHNEVNQREVSGTYLSTLGVKLIRGRFFTDAEDATKPNVVLINKALARKYYPGEDPIGKRIGDTQLTPTSIKEIVGIVDDVREAGLDQEIWPAIYDPFNQAPDTYMTMVVRTAADEKALLLTLVATAREINPGIGVSEETTMTAKINESPAAYLHRSAAWLVGGFAGLALILSVVGLYGVVAYSVSQRTKEIGVRMALGAARSSVSRLILKEAARLIVTGLLAGLVCSVGTAVLGRKLLFGTQAWDAGTLLGVALVLGVSAMMASWLPAHRAASVNPVDALRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N2</accession>
    <name>E8X2N2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581641.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70329">
        <property type="protein sequence ID" value="ADW70329"/>
        <property type="gene ID" value="AciX9_3320"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3320"/>
    <dbReference type="HOGENOM" id="CLU_1658357_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17897" checksum="458F68F6BBC72EFC" modified="2011-04-05" version="1">MARDNWISDAANKYGTHLQEKRSQQEMQRRAEERERERRERLSAERETEGGKLWAELQYILKGNVKQFNESYGDDVMRTEARADGPFKVKLGEPGGVEKIAALTYAPDVATLTWEIFGSNSGSLTVGLLLGERELQFMSGTAYVTTEAIAQQIIEALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q1</accession>
    <name>E8X2Q1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3340</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70348">
        <property type="protein sequence ID" value="ADW70348"/>
        <property type="gene ID" value="AciX9_3340"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3340"/>
    <dbReference type="HOGENOM" id="CLU_2699540_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8448" checksum="711D4459EB2644CF" modified="2011-04-05" version="1">MHRVERKVLAVTTFERTRNVCHFQLEDTTAGYVCFSRAVLMNNVLGGGVFAAIERWSALYLFLEREGVQLCWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Q7</accession>
    <name>E8X2Q7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3346</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581666.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3346"/>
    <dbReference type="EnsemblBacteria" id="ADW70354">
        <property type="protein sequence ID" value="ADW70354"/>
        <property type="gene ID" value="AciX9_3346"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3346"/>
    <dbReference type="HOGENOM" id="CLU_2117567_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="114" mass="11774" checksum="F763EEB99D75A37F" modified="2011-04-05" version="1">MSDVFLVGLFGHTGQGNEALTELLANGVAHEAIQVIGDLGAPAGQAGAMHHVTFDVLHISKEQRGQFMDGIRAGGVVLAVLGAGVAVEETLRKHEALVVERTDSKAGVVSHNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U1</accession>
    <name>E8X2U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3380</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70388">
        <property type="protein sequence ID" value="ADW70388"/>
        <property type="gene ID" value="AciX9_3380"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3380"/>
    <dbReference type="HOGENOM" id="CLU_3252254_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="42" mass="4599" checksum="C49AC208AA251042" modified="2011-04-05" version="1">MISTSLSQKEYVVILSEAQNLGICLPVQAHIPIQAPAQEHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V1</accession>
    <name>E8X2V1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1022</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579408.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1022"/>
    <dbReference type="EnsemblBacteria" id="ADW68085">
        <property type="protein sequence ID" value="ADW68085"/>
        <property type="gene ID" value="AciX9_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1022"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091584_0_0_0"/>
    <dbReference type="OMA" id="RYKNVYY"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="225" mass="24858" checksum="F39F718C5E40090E" modified="2011-04-05" version="1">MGLLMILALSTFTGHRRLLAFAHHPSIPFRYGSSIVLEWLLLGFVLARIRNRKAFLLQAFRSRSSTWLQSLGNGIAAYCLGFVAIAIVAIAIHFTPLGTKTNAAAMLAMLPRTTSQFALWLALSLTAGICEELIFRGYLTQQFTAWIRRPVLALVLSSLLFGSVHLYEGLAAILPLAALALVYGFIVRSLKGDIRAVIVAHTLQDFLVAVLALARPMLEHYRMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V5</accession>
    <name>E8X2V5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1026</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579412.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68089">
        <property type="protein sequence ID" value="ADW68089"/>
        <property type="gene ID" value="AciX9_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1026"/>
    <dbReference type="HOGENOM" id="CLU_1076727_0_0_0"/>
    <dbReference type="OrthoDB" id="2135899at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27809" checksum="0A260558FB26ADBC" modified="2011-04-05" version="1">MKGLNISIGTSSQHDSSNGWSSLITPDVAWRFNSHFSADATVPIYTYINVQQNKGTKARPVYVFANEKFTPGDAALNSHYETSFNLLDYNLTATLGLPSGSQDDGLGAGQVTYNFNNHFERAFGIISPDVEIGLGDSSQLVGDRVRKSYTAVGTLAHFQAGASIALTHNMNFEAEAYEELPLDAGTVYSTTGRGKKKVTTSAHTGGTEDNGFLNTLDIPLNGHVVVSGFYNRSLRSKIDTAGFSLTFLLRSPPADVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X307</accession>
    <name>E8X307_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/H associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1078</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1078"/>
    <dbReference type="EnsemblBacteria" id="ADW68141">
        <property type="protein sequence ID" value="ADW68141"/>
        <property type="gene ID" value="AciX9_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1078"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_3_1_0"/>
    <dbReference type="OMA" id="LPFWHGD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="356"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1609" mass="175306" checksum="FF026ACBA7DFFCF0" modified="2011-04-05" version="1">MMAAVGTKKAAKAAVKKVGKKLATAAEAVAEVSGADAALALFHPVTARWFREVFDGPTAPQIEGWPAIARGESTLILAPTGTGKTLTAFLWCLDKLMLRDVSAGVERGCRVVYLSPLKALAADVERNLRSPLAGIANFARREGVPVHLPEISVRTGDTPAKDRARFNRHPGEILITTPESLYLMLTSAAAEQLRTVETVIVDEIHALVPSKRGAHMALSLERLEALVAQGGTGRKIQRIGLSATQRPLEEVARFLGGAEMVVTHVPESGHGAPSLVANIEGEVPQALMEVARDEVEASTGGPRFRPVTIVNAGARKVLDLRVEVPVEDMAKLGEIQEQPSGPASQGPKRTSIWQSIHPRLLEIIRGRTSTLIFVNARRVAERLAGAINDLAGEPLARAHHGSLAAAQRTEIEELLKAGKIKALVCTSSLELGIDMGAIDLVIQIEAPPSVASGMQRIGRAGHQVGQPSNGIIFPKYRADLVACAAVTRAMHEGHVESTRFLRNPLDVLAQQMVAIIARPPAELPPLKKGKKAPLVEVTEEEEATGISYDELLGLVRSCANFAGLTQAVFDGVLDMLAGRYPSDEFAELRPRITWDRQRNWLTPRQGVKKIAILNGGTIPDRGLYGVFLAGTASGKPIRVGELDEEMVFEQRTGDTFILGASTWRVEEITHDRVLVSPAPGDPGKMPFWHGDQAGRPLEFGRRIGALVRGLRETPRSVAITTLTADHDLDPQAAENVMRYLADQELATEVVPDDRNIVIERVRDELGDWRMCCLTPFGSKIHAPWAMAVTARIRANGGPEVETMWSEDGFVLRFPESDTPPTIDHLMMEPEEAAELVLRQLGSTALFAAKFRESASRALLLPRRRADGRTPLWQQRKRAYDLLSVASRYASFPILLEAYRECLRDVFDMPALMEILRAIGNRSLRVHTADSRTPSPFAAALLFSYVANYIYDGDAPLAERRAQALSIDQDQLRELMGDADLRELLDLGAIEETEEQLQCLAETYRARSMDGVHDLLLKLGDLSRAELLVRCVSPEIALTVERLRKAIRVLEVGIGGEKRLIAVEDAGRYRDALGVPLPPGLPSAFQVAVPDATLDLLRRYGRTHGPFTTAEVAKRFGLALETAEGVLNRLVGLGRIVEGGFRPGGTHREWCDHEVLRAIRRKSLAKLRKEVEPVEQATLARLFTRWQGVVQPRRGLDALLDVIENLQGAPIPASVLETEVLPARILGYKPADLDTLVAAGEVVWCGLDAIGERDGRVALYLAEKLPLLWPVRPEQGSGDRGQGSDSSPTAEREGKVVEYLKANGASFFQQLHDGTGGGYPGETIEAIWNLVWRGLLTNDAVHALRAYCERPAASSKPARRVHNQVGFRSRRTTPPTAQGRWSLNAVAFEEGRNGTEWSHAVAQQLLGRYGVVFRETAHAEGLPGGFSAVYDVLKVMEESGKLRRGYFAADLGATQFAMPAAVDLLRSLRVVRDGEKAEMVQLAATDPANPYGALLRWPAAGEGVSLQRSAGARVILCDGALLAYMRRGNPNLQVFLPEEEPQRTQSAKALGEFLVARAHSHDAGMLITSLNGTSVHEHWAARALLEAGFMAAPMGFNVRRILPALPKSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X325</accession>
    <name>E8X325_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2205</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580565.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2205"/>
    <dbReference type="EnsemblBacteria" id="ADW69249">
        <property type="protein sequence ID" value="ADW69249"/>
        <property type="gene ID" value="AciX9_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2205"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034785_0_0_0"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230615" description="DUF218 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13052" checksum="79D3F61AC12597C5" modified="2011-04-05" version="1">MVKRLGWLFLFVMTLAVIAAMVTFEAMPTHNTDATHFDTIIVLGWPTAPDGKASKIQTARVMEAVRELMAGRAGHIIVSGGAAHSQFVEAEAMAKVAIEAGVPQEDVIVEGRAMNTIQNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X335</accession>
    <name>E8X335_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580575.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69259">
        <property type="protein sequence ID" value="ADW69259"/>
        <property type="gene ID" value="AciX9_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2216"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834029_0_0_0"/>
    <dbReference type="OrthoDB" id="712818at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230190" evidence="1">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="42865" checksum="D93D5CA0BDFCD9E9" modified="2011-04-05" version="1">MKTVVGALALGVTFFSVAPLLSQTPSFYLVPDDVRAQYQRPGVVPYASTAVPGTSAAKPFMSFDIISFDQRTQLMTLSSRSSKAVAIFDGLTGIPIGETPAVFAGVGASNDISGPNGNVIAGDQLWAGDYPSTVRVFDLRANPSNPPQIAVIDTGGTQRADEMDYDPADGLVAVSNGDTAPAFVTLISTKTLKIVKRITFDGSHGTVNASPGGIGSVLFDKNIGKFLISIPQIGDKTDLGAVAVIDPKSGTVEKIFKHIDRCMAAGMAKGPGDNVLIGCDPGFPAPDATFTPLTYVINDKTGAIVARIKEVGGEDEVWYNPGNHRYYTGSRDFFTNAAATKATPVLGVINADTNQWIENVPTGTNAHSVTANPFTNAIFVPLEDPNQVCGPIPGCLGIYHTDYFQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X383</accession>
    <name>E8X383_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PKD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2269</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580623.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2269"/>
    <dbReference type="EnsemblBacteria" id="ADW69307">
        <property type="protein sequence ID" value="ADW69307"/>
        <property type="gene ID" value="AciX9_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2269"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037124_0_0_0"/>
    <dbReference type="OMA" id="RAPMQNF"/>
    <dbReference type="OrthoDB" id="454820at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230194" evidence="1">
        <location>
            <begin position="31"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="551" mass="56332" checksum="82CB4FE118A524F9" modified="2011-04-05" version="1">MVYRPFSSIGRLGLAACAVSLGVASLSAQSAPSTTAPVGPNPSRVDIFTGFSYFGAHGQVKPAGINYSSINEGAIGSVAYYFNKYVGAEANLVAHPDGANDGLYTASGGLIVRAPMQNFTLFAHGLAGASRLVGPNSDNAATFEHEPYTTGVGLTAGGGMDYDLPFFNNRFSLRLFEADYRYIHTDFGPATTVPTGGTLGGRANLSGVDLSTGIVTHFGHIIPPPPVTYACAVAPAVGYPGDPLTVTGTATNLNPKKTATYSWTSTGGAVVSGTSNVGNIDTKTLAAGTYTIKGHVSEGNKPGQMADCSADFQVKAFEPPTISCSANPSTVSPGDSAMVTASGMSPQNRPLTYSYTASAGSISGSSSSATLATTGAAPGTITVTCNVVDDKGQTATSTTSVTVVAPAPPPAPTTSALCSISFDRDTKRPTRVDNEGKACLDDLALNLQRTTDAKLAVVGNAASAEKMGPHKAAERAVNTKAYLVGEKGIDASRVNVYTGTTDAKTVTDTLVPAGATMDMTGVTPVDESAVKALPRKALPAGHKHHKHHKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8X386</accession>
    <name>E8X386_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="9" type="ordered locus">AciX9_2272</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580626.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2272"/>
    <dbReference type="EnsemblBacteria" id="ADW69310">
        <property type="protein sequence ID" value="ADW69310"/>
        <property type="gene ID" value="AciX9_2272"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2272"/>
    <dbReference type="eggNOG" id="COG2844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012833_1_0_0"/>
    <dbReference type="OMA" id="WIAKYVY"/>
    <dbReference type="OrthoDB" id="162558at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="696"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="819"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="891" mass="99722" checksum="96A30A213A3646F7" modified="2011-04-05" version="1">MAEDAQIAAAIERRRQYESDILALRTSFKERLHLPSAGVTAVYDRSAIVDALVSQLWAETSFPPGVTLVAVGGYGRRELFPYSDVDLMFLLDGRIPEKELKTPVRQLNQCLWDCGLRVSPMTRTLAECEKFNPENVEFTLALLDARFLVGDLALFTKLTEKSLPRLIARDRKKIIARLAEVTRTRHRKYGDTLFHLEPNIKDCPGGLRDAHVFAWLTRLVEHPSPAPDPSFLEARQFLLLVRTFLHLRHQRDDNTLDWHAQDEAASASLGISPPPRSPIDAAYWMRLYFRHARSIERNAARCLEEAAPTKSQSRLPGMAALRRLSGEPAQPGFEIHQNTIVLAPAGAEDPAENPEVMLSLFATVARTGARCSGETEQRLERALPLLSAHLEDGPGLWRRLEQILTGQYAGLALRSMHALGILELVIPEFHGIDALVIRDAYHRYTVDEHTFVLIDILHALTAVTPSKNPVGLDQWAARFSPILRDLPHPSLLYLAALLHDTGKGHSTSAHAVESARMAQSVVQRLELDAYESGLVLNLIRNHLEMSAALRRDVFDAETVRSFAPKVLTPEALRMLTLFTYADIAAVHPDALTPWKAENLHRLYMATADYLDRNVDDERVGVATESEVGELIHRVSALLPGKRAELDRFLEGFPQRYLLTRNPDQLRSHFNMASLLEAGPAQDTIQLDFRYSPEVSELTLITRDRPMLFASMAGALAAWGMNIVTADAFSNAHSIVVDSFRFTDTFRTLEMNEEERDRFVESIRKAIGEELSREEKGELIGASPIETMLASRRRNRRKTPKVQVETRVDFNNAASSHSTLLQVVSLDTPGLLRALSLTLAAHECNIEVALVDTEGEMAIDVFYITHSGAKLTPEAQDSLRRTLLEAIQANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D9</accession>
    <name>E8X3D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3434</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581752.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3434"/>
    <dbReference type="EnsemblBacteria" id="ADW70440">
        <property type="protein sequence ID" value="ADW70440"/>
        <property type="gene ID" value="AciX9_3434"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3434"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042159_0_0_0"/>
    <dbReference type="OMA" id="HGQSWGG"/>
    <dbReference type="OrthoDB" id="865015at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234322" evidence="1">
        <location>
            <begin position="23"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="409" mass="44919" checksum="571EDDBE10BB6600" modified="2011-04-05" version="1">MKTSARLLLCVLALALPVRAFAAADRNRPDSPPEVVHTSTGLTETGILNGASYRIDIPSNWNHSLVVYYHGYSEGVFLYRATAPLNEQTQPLYDRGYALIQSAYSTAGWALAEAYPETEQLRQYFIKHYGQPATGKAAAKSMETIVAGGSMGGALVVATLELNPKPYVGGLDICGSVGPTDLAFQRRFAWRAAFDFYFPGLLPPVVITPLEFHESTALRQRIEAALTAAPASAAAMRNLMGLHTDREVAIAIPYFTYVIGDIQHRAGGNAFDNRNFLYTGTNPSTTTTDNALNDGVKRYSADPHAREYLLHHYTPTGRLNKPMVALHTTYDPRIPGSTLTVYAEQVAVAGFSQNLVQQYVHRDGHCTFTADEVGRTFDELMTWVHTGRRPTPGLLPATIARDQQKELPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3L5</accession>
    <name>E8X3L5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_1143</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579529.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1143"/>
    <dbReference type="EnsemblBacteria" id="ADW68206">
        <property type="protein sequence ID" value="ADW68206"/>
        <property type="gene ID" value="AciX9_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1143"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_0"/>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="419"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="511" mass="54003" checksum="ACCDB0DCC0945DDA" modified="2011-04-05" version="1">MELFDFVVVGGGIAGLSAVVRLAGAGRVLCVTKESFAESNTAYAQGGIAVAMGGSEDVSLHLADTIAAGDGLVNAAAAKVLVEQGPRRVEELLGWGTEFDRAVGGELLRTREGAHSLSRILHANGDATGREIARALLKYVQGLKNVELRDWTVTVDLMVEKGRVEGVVLLDKAGTLARVGARAVMIASGGAGQVYSDTTNPAVATGDGIAMAYRAGAAVEDMEFYQFHPTAFAMDGAPRFLMSEALRGEGAVLINAAGERFMPAIHPMAELAPRDVVARAITREGLNGPVYLDMRGVTEIDLKARFPGISAFLAGYGLSLAKDLIPVRPAAHYLMGGIKTDVWGKSSLQGLYAAGEAACTGVHGANRLASNSLLEGLVFGVLAAESMVKEQGSGGKVEAAGEVVKAGGSDEGVEEWIAELRAIMWENAGLLRDSAGLKRGQARLDGMFRRMPRGVTRRQLEARNLYALAGVMVESALGREESRGAHFRSDFPEKGPIARHSVMERGRLRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M5</accession>
    <name>E8X3M5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpA</name>
        <name evidence="13" type="ordered locus">AciX9_1153</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579539.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1153"/>
    <dbReference type="EnsemblBacteria" id="ADW68216">
        <property type="protein sequence ID" value="ADW68216"/>
        <property type="gene ID" value="AciX9_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1153"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_0"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="150"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="373"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="515" mass="55669" checksum="AD91F1C76F498762" modified="2011-04-05" version="1">MAQIKADEITELLRQKIENYEQKVQVDEVGTIMSLGDGIARVHGLDKVMAGELIDFPHGVAGLAMNLDEDQVGAVLLGDYTLLREGDQVKRTGKIMSVPVGKELIGRVVNALGQPIDDKGPINATQTLPVERLAPGVIDRQSVKEPMATGIKAIDTMIPIGRGQRELLIGDRQTGKTAIALDTIINSAKNNLICIYCAVGQKRSSVAQVVQTLEEYGAMAYTIVVAATASEPAPMQYLAPFAATAMGEYFRDNGMHALIIYDDLSKHAASYREISLLLRRPPGREAYPGDVFYLHSRLLERSSKVSDKLGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFVETDLFNSGVRPAVNVGLSVSRVGFAAATKATKQVGATLKLDLAQYRELAAFSQFGSDLDKVTQNQLNRGARLVELLKQPQYKPLSAEKQVAIIYAGVNGLLDDVEVKDLRAFEDGFYPYLESVQPAILTDIATKKALDDDLKARLKAAILDYKGGFLADHKQEKAVAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P8</accession>
    <name>E8X3P8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ordered locus">AciX9_2288</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2288"/>
    <dbReference type="EnsemblBacteria" id="ADW69326">
        <property type="protein sequence ID" value="ADW69326"/>
        <property type="gene ID" value="AciX9_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2288"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_1_0"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="294" mass="31690" checksum="ED57C59042F4062A" modified="2011-04-05" version="1">MPPLNGLLILDKPTGMTSHDVVSIVRRATGEKSIGHLGTLDPMATGVLPLLLGKYTRLAQFFNQAEKSYTGHIRFGFATDTFDAEGTPATDPKPLTQSLEDLRTLAEKFHGDLDQIPPVYSAKKLGGVPAHKLARAGLPVPVKPARIHIHDFQLLDLEADTTTFQMTVSAGGYVRSVAHELGELAGSGAHLSSLRRTRAGLFTLAHAITVDQLKQASTDETITELLPHPRTLLPDMPSVTVDDQAAGRLRNGMQVNLPDFSQAPLIKVFTSPTDLLCIAKRIAGTLMHPMVVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T3</accession>
    <name>E8X3T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2324</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69361">
        <property type="protein sequence ID" value="ADW69361"/>
        <property type="gene ID" value="AciX9_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2324"/>
    <dbReference type="HOGENOM" id="CLU_2142377_0_0_0"/>
    <dbReference type="OMA" id="DSEMTLM"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234143" evidence="1">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="11331" checksum="DF01A458FF09984B" modified="2011-04-05" version="1">MRTMKSVVLPAAAALCLLVPSFSAFAQAAPAPTAQTAKKGKTVKFTLQNTTKAPIALKSGDDQISLAAGESRAVKIPAGTRITTVADSSTGPSGTVVTEVTEDMGGATVNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U5</accession>
    <name>E8X3U5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ordered locus">AciX9_2336</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580689.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2336"/>
    <dbReference type="EnsemblBacteria" id="ADW69373">
        <property type="protein sequence ID" value="ADW69373"/>
        <property type="gene ID" value="AciX9_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2336"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_0"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="10270" checksum="88E8EB1B5D8FE76F" modified="2011-04-05" version="1">MLAPVKKTDIIAKFRTHDSDTGSPEVQIAILTERITELTEHFKTHKKDHGSRRGLLMLVSKRRRLLDYLKKVDADRYREVISKLGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V3</accession>
    <name>E8X3V3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgI</name>
        <name evidence="4" type="ordered locus">AciX9_2344</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2344"/>
    <dbReference type="EnsemblBacteria" id="ADW69381">
        <property type="protein sequence ID" value="ADW69381"/>
        <property type="gene ID" value="AciX9_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2344"/>
    <dbReference type="eggNOG" id="COG1706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045235_1_0_0"/>
    <dbReference type="OMA" id="QFRPKNV"/>
    <dbReference type="OrthoDB" id="693640at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="41983" checksum="CAB49700C69D20D1" modified="2011-04-05" version="1">MKKLHYTQHICEAEREFQDRPSMVRILLSVVGLMGLAAALVQGQAPVQAAMVTPVRQARVKDIASIEGIRDNQLVGYGLVVGLNGTGDSQQTTFPTQTLSAILLRMGVSVPASAIKVQNLAAVFVAASLPPFARPGTKLDITVSSAGDARSLEGGLLLMTPLYGADGKIYAQAQGPLVLGGYSVTANGSTKSLNHPTTARVPFGATAERGVALELEGRRQFSILLNDEDFHSAEAMAEAINKDLARPLAKAYDSRRVELAVPAGEDVPMLLSRVEAVQVSLYPRAKVIVNERTGTVVIGGTVVLQPVSILHGGLAVNVVTDFNVSQPGPFSNGTTTTVPVTRIEAHDKPVSRIELKQGATVDDLVRSLQTIGASARDVISILQAMKSAGALEAEIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X4</accession>
    <name>E8X3X4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="10" type="ordered locus">AciX9_3477</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581793.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3477"/>
    <dbReference type="EnsemblBacteria" id="ADW70482">
        <property type="protein sequence ID" value="ADW70482"/>
        <property type="gene ID" value="AciX9_3477"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3477"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_5_0_0"/>
    <dbReference type="OMA" id="YHSSVQA"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="46750" checksum="AEF78CA750687181" modified="2011-04-05" version="1">MSDSRFAPVEDQLALLTKGAAEIIPLDDLRTRLEASLKSGKPLRVKAGFDPTAPDLHLGHTVLMRKLRHFQQLGHTVIFLIGDSTALIGDPTGKSQTRKQLTQAEIDANAETYKQQVFRILDESKTEVRYNSEWLAKLGFADMIRLAAKATVSQMLEREDFHQRFNNEEPISLHELLYPLAQGYDSVALECDVELGGTDQKFNLLMGRRLQRDAGQLPQIVLMTPILEGLDGVQKMSKSLGNAVGVEDSPFDMFTKLMTIPDALIGRYFTFLTDLLPAQIAVIEEQIVAGQLHPMQAKRDLARTIVEGFHTLEVAAHAEENWSKQFQQGGVSDDIEEVGITQAEIAGPEAHNAQDGVTGFTIKLPPLLVHCGLCPSNSEATRKLREGAVKIDGEVQKDAVMQLASLPVTLTIRLGKKAKRAVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X462</accession>
    <name>E8X462_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0031</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578451.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67122">
        <property type="protein sequence ID" value="ADW67122"/>
        <property type="gene ID" value="AciX9_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0031"/>
    <dbReference type="eggNOG" id="ENOG5032XGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407030_0_0_0"/>
    <dbReference type="OrthoDB" id="1854776at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="193" mass="21255" checksum="861B0961B45E617E" modified="2011-04-05" version="1">MSAALVILPVIQAMAEVASRPAAGPISATGAALRKGPHRLTLVRASAAVLPDAEERIRLRPSPELSFYRKYTEAMLKRYTKLSMEAGRAPSLLGRELFRGHVTNYKVSSFDDVVIYVHDVENCVAKLGRGQQYLVRKIAMQGYTQQETAAMIGTNLKIVIKRYVEAIDLLTRLFLDLGLLAPTVASKRVTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F1</accession>
    <name>E8X4F1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1215</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579601.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1215"/>
    <dbReference type="EnsemblBacteria" id="ADW68278">
        <property type="protein sequence ID" value="ADW68278"/>
        <property type="gene ID" value="AciX9_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1215"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_1_0"/>
    <dbReference type="OMA" id="FVTGMEP"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008354">
        <property type="entry name" value="Glc-Fru_OxRdtase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01775">
        <property type="entry name" value="GLFROXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="150"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="386" mass="41786" checksum="2413A014B7A3C049" modified="2011-04-05" version="1">MDLKEALGFGVGKKVRYAIVGLGDIAQEDMMPGVGHTGNSEISVLITSDPVKARELGEKYGVQAAFTYEQFGEALASGTFDAIYLATPNWRHAEFIVPALQAGIHVLTEKPLEVSTEKCKEILAAEKASSAKLMVAYRLHFEPGTLDTIEKVRSGELGRVHLFTSTFAQMVDPENHRAHSGKLAGPVLDMGPYPVNAARYIFEDEPTEVVSAVGTKHPESGFDQDFADTVAVTLRFPGERLAQFTLSYFGNATNFFTAVGTKGSVQLDPAYMFGKGLEQTTAIGEKKSKESFKNTDHFGGEMKYFSDCILNGTEPEPDGEEGFADVRVLEGIIKAVETGQAVMLEPFSRSKRIDTAAQKMTLGAVSTPELVDASNPGMGVEKQPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N9</accession>
    <name>E8X4N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2412</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580765.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2412"/>
    <dbReference type="EnsemblBacteria" id="ADW69449">
        <property type="protein sequence ID" value="ADW69449"/>
        <property type="gene ID" value="AciX9_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2412"/>
    <dbReference type="eggNOG" id="ENOG5033KJR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022187_0_0_0"/>
    <dbReference type="OMA" id="DHAGVEW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="29251" checksum="BF01834C3DF0BB0B" modified="2011-04-05" version="1">MKAFQQYWTFSAIRGAMTILASCFILALPLTTSSMLSLPVLVALAIDCLATYTIFDGAVMILLERLMPTRATNRRILYGQAGIALVLGTTFYLFGYGMLNQSWLLWIVAAQAAMAAGAEFLIARNTHQEYGCLSCYSTSMVLGLCAVFLPFANGLNATDTSYVLAAYVGLYGASELFLGGRMLFAEYRSEHPAAVASEAWKVAMLEPEAAPLLPLAARRICSNCVECPADSLCHDNSLSGQVGMVLAERRPAIVVSTRVVASLSKQPHPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X563</accession>
    <name>E8X563_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579650.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1265"/>
    <dbReference type="EnsemblBacteria" id="ADW68327">
        <property type="protein sequence ID" value="ADW68327"/>
        <property type="gene ID" value="AciX9_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1265"/>
    <dbReference type="HOGENOM" id="CLU_2316355_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="11265" checksum="BBA057AF8E913B15" modified="2011-04-05" version="1">MATATPNTPSQRTVVLLRPNEKKRLLKLAREEKVSSSEILRRSLNAYQSGSSDSEEHQLKKLFAEMNAALDDALISTRNARVEIAEDLAQMRQRREQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X574</accession>
    <name>E8X574_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative magnesium chelatase, ChlI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579661.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1276"/>
    <dbReference type="EnsemblBacteria" id="ADW68338">
        <property type="protein sequence ID" value="ADW68338"/>
        <property type="gene ID" value="AciX9_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1276"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043779_0_0_0"/>
    <dbReference type="OMA" id="GMIPRAN"/>
    <dbReference type="OrthoDB" id="325470at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="178"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="517" mass="57404" checksum="1323EDADB2F8ECC1" modified="2011-04-05" version="1">MANTALPQTLGQLRASEFTAALVGRSVKDELRDNLIVRLRETAKTKAPLFPGIVGYDDTVIPQIVNAVLSRHNFILLGLRGQAKSRILRALTTLLDPQSPYVAGSELRDNPYAPLSRYSKNLIAEQGDDTPIAWMTPQERYVEKLATPDVTVADLIGDVDPIKAARSGQELGSELTMHYGLLPRANRGIFAINEVPDLAGKIQVALFNIMQEGDVQIKGYPVRLELDVAIVFSANPEDYTARGKIVTPLKDRIGSEIRTHYPESIDEAISITEQEAWTARSYAAGNDAISKIEIPHYIRQIVENIAFAAREDKKVDKRSGVSQRLPISTMELVVSNAERRALIHGESTVVPRVGDIYAALPGISGKIELEYEGEMRGADTVIREIIRTSVATVFDQYFADQNTQQIEQWFNLGGTVQFDDTQSSAAVLTALKGIQGLFDKLTPFHITAKSQPEIAVSAAEFLLEGMTAHKRISRSEERAFTAAEKKQRNKDASEFAERVRDREFEDNPRNRSRRGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5H4</accession>
    <name>E8X5H4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2488"/>
    <dbReference type="EnsemblBacteria" id="ADW69521">
        <property type="protein sequence ID" value="ADW69521"/>
        <property type="gene ID" value="AciX9_2488"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2488"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013590_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="730" mass="81124" checksum="69866D5243F915A8" modified="2011-04-05" version="1">MDLPGSPVDGGGGVPVPDSKLPVRYELPFGDNPYLPSEARSEFSGFLQPSEIPTAAYCGHCHSDVHAQWRQSGHANSFRAPWYVKNVGELGETRGVPYTRHCEGCHNPAALFTGALTTKSSVARPNDEDGVTCMVCHSIKQVTSTKGIGSYVLGRPAVMVDAAGKPVSGMPSDVEILTHLDRHKAAVMQPLYKTSEFCAACHKAAIPQMVNDYKWLRTFSTYDEWQQSSWSKETPLSFYKKPEAVGCQGCHMVREASSDVAAKAGMTASHRWVGANTAVPAQYGFDEQAKRVVEFLKKDQMEVDIFGLTVERGGKTTAGLVAPLGSKAFTVLPGDWVRVDVVVRNKGIGHTLIPELRDFYESWLDFEVKDDGGRTIYRSGGLDSLHKVDPKARSYGLRIVSSDGKSIDHHEVWKTRTKAYDATVLPGKSDVVRYRFQIPLESKGMTVSAAVRYRRFRREFTDWVFGDKPEASDRFPTVTLASGSLHIDAGVNEAKGEVLPAGLTEVLRWNNYGIGMLDRLQFAEAVEAFHQVLKLDPKYQPGYVNVAVGEYSRGRYDEALRWLDRGLQMDPADARAMYFKGLCLRWQTHFDEAIAVLEPVAKQYPRFRQVHQELGYVYMVRRRFPEAKAEYEAVLKIDPDDPVAHRWLGPVLAALGDAKGAAAESKMAAATGNDTSAGWLAQRFWREHLDIASEAMPGHTHSPGNERDDADVHKVLNLQNPPSYIWVDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5S8</accession>
    <name>E8X5S8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4016</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572724.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70812">
        <property type="protein sequence ID" value="ADW70812"/>
        <property type="gene ID" value="AciX9_4016"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4016"/>
    <dbReference type="HOGENOM" id="CLU_016031_0_0_0"/>
    <dbReference type="OMA" id="HFYYGHG"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="453" mass="46681" checksum="C81CA8DE3CC2DE9B" modified="2011-04-05" version="1">MRFIFGVFGCGLGLLAGVAGGQDSRTVTEPVIPVACVSLDARITGQGGGIAAADEGKLDTERIQKAMDGCGAGKSVVLRGRDGANAFLSGPLQMRAGVALVVDKGVTLYESVDPKVLEVSPGSCGIVSATPGRGCRPLISVENVKGAGVMGDGVIDGRGGVKMAGVGKSAWDLAEEARPGGGQKVSRLIVANHADDFTLYRITLRNSPNFHVVYNAGDGFTVWGVKIDTPGKGARNTDGIDPGAGSKNITVTHSFISTGDDDIAIKGGTGGLTQMTVSHNHFYRGHGMSIGSETNGGVSKVRVFDLSIDGADNGIRIKSNAARGGLVHDVSYEDVCVRNSPNPILLDTAYSANGSMEGTLYPSFVDITLRRVSVAGGGKISFNGFAKDHRVGVNLDDVVVDGGKYSYSVNHADFKVGPGAMNLNLAGEDVTKNGTAGSGAGKRCEGMFVAFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U6</accession>
    <name>E8X5U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4034</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572742.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70830">
        <property type="protein sequence ID" value="ADW70830"/>
        <property type="gene ID" value="AciX9_4034"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4034"/>
    <dbReference type="HOGENOM" id="CLU_008287_22_1_0"/>
    <dbReference type="OMA" id="DSYWASA"/>
    <dbReference type="OrthoDB" id="196825at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230262" evidence="6">
        <location>
            <begin position="25"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="148"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="337"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="815" mass="87508" checksum="E787E9DD4E006868" modified="2011-04-05" version="1">MHSSAVVRPLIYLSLISTAVGALAQSSQVAGTVKDPERSLVGSAVVTLEEMQSGRLQKTVTDASGQYSFSAVTAGKYRLVIKKDGFAPIVIAPLTVAEGQSVNQDGTFDVAGVSSQVTVNGNATGSSEDGYAVSKVNRGVMGDAPVVNQPYTITVIPADEIANTQVKNLRDTIKYLPLVSFTEQQGPEILRPATRGVQGSIAQNTRMDGMSIAITGGNPMEQYQEMQVESGLGAAMYGPANPSGMFDFVLKRPTEERTANIFLEQDSSSIGTVYGDFGGRLGPHKIFGYRSNLLFGDGTQFVAESRLRRRLAEFAFDLRPTPATTIDAHYSVYDIVQRGYPGWFSYGPSSKTNVAAADFILPLAPDPTRVGFGQAYAGVNLTTQSTSVRVLHDFSPNWHATAGGTAQRLDRFIDTPVNTIMDNAGDYSSSLSSGFAPRFGVESDLGYITGVIKKWGIKQDVALASEGYRFNQYSYTANSAASLFLGLANVNNPVVFAAPTVGLPHNRGLYQSAVVHQQGFNLGDLITFPAHILVRVAASQDFIGVDNNSATARTSGSNKQGISPSASVLYKPTTWSTAYATYASSLQQGDLAPVSATLVNSGAALAPYRSKEWELGFKTDLHPLAITTALFRLERPFADTLSYNGSTTQNIFAIAGQQVNFGAEISAQGTLFRRLLIDGGFTALNARLNDTNVASTEGKRFVGIPSYKSNFLSEYRVPGIANLNITGDWQFVGKRPQDDQNLHTTTGYNTFDFGFRYSRPVFARVATLRFTCDNITNTRYYSTISAGDITGANASANLAHLGSPRTISSSLQFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X653</accession>
    <name>E8X653_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_4157</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
            <plasmid evidence="12">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572849.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70937">
        <property type="protein sequence ID" value="ADW70937"/>
        <property type="gene ID" value="AciX9_4157"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4157"/>
    <dbReference type="HOGENOM" id="CLU_068213_0_0_0"/>
    <dbReference type="OMA" id="MGIIITM"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022522">
        <property type="entry name" value="Flagellar_motor_stator_MotA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30433:SF4">
        <property type="entry name" value="PTHR30433:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03818">
        <property type="entry name" value="MotA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="10">
        <location>
            <begin position="135"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="30614" checksum="66C7556F33C1E7C8" modified="2011-04-05" version="1">MISIIGIIVVFGAVIGGFMMEKGQLAVLVQPAELVTIGGAALGTLLVANPMHILKGIASGLMGVIGGSPFTKQRYLDTLKMMFDLFSKARKDGMVAIEADVEGADKSPIFTAYPKFMKDHHAVDFVCDTMRMAITGGVLPFDVDQMMELDMDTHHHSSSLPTTALNTVADALPGLGIVAAVLGIVITMGALGGPPEEIGHKVAAALVGTFLGILLCYGVLGPLASFMGKMNEEEHAYYHILRVVMLAFIKGTSPILAVELARRAIPAHLRPSFSEVEKACRNKSAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C6</accession>
    <name>E8X6C6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4234</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572922.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71010">
        <property type="protein sequence ID" value="ADW71010"/>
        <property type="gene ID" value="AciX9_4234"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4234"/>
    <dbReference type="HOGENOM" id="CLU_020161_7_0_0"/>
    <dbReference type="OMA" id="SNQRWTR"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234237" description="Beta-xylanase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="6">
        <location>
            <begin position="46"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="376" mass="41538" checksum="22715FA59E09B81F" modified="2011-04-05" version="1">MKPQPNRRTFLQTASAGLLGSALPAPLLALSDNKQPWTPLGRLAQEKNISFGFALNYRLLSGNQDYDALVSRECTIVTPENAMKWEAVHPEPDRYTFTQADAILDFAQQHAMKIRGHAFCWHRALPAWVTHDVTKQNAEEVLRQHIATVAGRYKGKLHSWDVVNEAIQLKDNQPGGWRNSFWFQQLGPAYLDIAFDAASQADPAAILTYNDYGLEYENHSDSAKRKAVLTMLHDLKKHGIPVRALGMQSHLRAGTGESFGSDLPSFIKEVRDLGLEIFVTELDVDDSHLTVPDLARDSAIADVYKRYLDLVLSTTAVSVVITWGAWDIVKVTGAEATSGPSAQHPLLFAPGGLPKLDAALVAQSFRTAPLQHQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R1</accession>
    <name>E8X6R1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3935</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71211">
        <property type="protein sequence ID" value="ADW71211"/>
        <property type="gene ID" value="AciX9_3935"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3935"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_0"/>
    <dbReference type="OMA" id="TCHFGQA"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="297" mass="32660" checksum="86AA6C073705A9BD" modified="2011-04-05" version="1">MRYFVELRHLRSFLAVAEALSFVRASERLHLSQPALTAQIQQLEEELGLLLFIRNKRSVRLSDAGVVFVDEARETLARAAKAIERVRKASLGEIGQLRIGFVSSAALEIVPKIVVAFQTRYPLVELDLINLRSSTQLEQLSANGLDVGFVRLPVNYKGLDFLPIHKEPFVVVLPVHHGLATKSKFSLGDLREERFVAYGRKWAPGFFDQIVSLCSAAGFTPNIVQETGEMYTAIALVAAGQGVAILPRSVVLAQGRGVVVKNLPGALRSEIAIAVKEGQQSRLVGNFISLARRPKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z1</accession>
    <name>E8X6Z1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71100">
        <property type="protein sequence ID" value="ADW71100"/>
        <property type="gene ID" value="AciX9_3814"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3814"/>
    <dbReference type="HOGENOM" id="CLU_000445_28_2_0"/>
    <dbReference type="OMA" id="IARECHD"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="915"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1033" mass="112527" checksum="B12EFD56E9C8C9A8" modified="2011-04-05" version="1">MTEHVHSVRHLRLARPVSFALGVLASLLCLVAGLNAMPVSDLKLSEYQKQDWQVEDGLSDNYVRMVAQRPDGTLLLASSSGIDSFDGLHFHNLPIEGTGVLQNEAVNAILVNGNDDLWIGTDGRGILHHTPAGTINISERAGLFNERVRAFYRDGSQAVWIATQNGVERFANGHLEIVPNTGMISGDITTPFAEDNHGGIFFVTSSGLFHWSKGVTQRITLPLPSSDAPVAVYRDPQKRIWVGTMKHLLQLSAAHPASHGAPYDWLTLATIPSPATVLLGDAPGHLWIGTRHAGLWQFGTNGLSSWTTRDGLPDDTIRTLYVDDEQNLWIGMRTGGLSRWRKAPLAPFGAPEGFHANYSANVLADSHGDLWLGTWGAGIFRQHNGKLLPTNPPGMPLTSPIRVLAEDRDGHLWVGTWVDGLYHYNGKTFQHYLLGTESPANAISAILPARDGALWVGTYTGLFYFRSGQPHPQLRSQLLESQLITCLLEDRDGSILVGTSTGLYRIRDGKASAISGLPIPHILSLTSDSQGYVWASTRGGGLFAVRGETVMPVPAKAGLPDFSINTVVEDLDGHLWLGTARGIIRVAVADLHAAVDGTQIQLPLVLLGKNDGMRSSECGGPSTPGAARLPDGTLWFVTTKGFVHTTDVAEKLGASSPVASITGWTLSNDPTDAAAVVPNDPTATLDLEPGQPDIHFFFAAKLLANPNHIQFRYRLKGYDTDWTITKAQTARYYRLPPGHYSFEVQARIAGEEWSSSVATIAVKAHPYFYQTWYFYLALTVASLAFAVHLFRRRVQAMKGRIGIVLEERNRIARECHDTLMAGFAAISWQLEATAKLFRDSGAEATPTAASCELARSMVSHCQAEARRIIWDLRDTDEVTNLLSEAISRTLSANQIRETVETSFELEGDEVPLAPGCVHHLVCIGQEAISNAIHHAAPTHIAVRLLYERDSLSLSIRDNGRGFLNHGPITSTGAASSRTGHFGIPVMEERARKLGGNFKLQSSAGNGTEITVKVGFHALQVTNQEQHLIRWIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X724</accession>
    <name>E8X724_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582155.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71133">
        <property type="protein sequence ID" value="ADW71133"/>
        <property type="gene ID" value="AciX9_3847"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3847"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="YCVTFTG"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230838" evidence="2">
        <location>
            <begin position="37"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1136" mass="121992" checksum="94B689EA676B7B9C" modified="2011-04-05" version="1">MTNIFNQTRTSQKLSRAAGLGMLAGSLTMMLPSAMAQSDTGRVVGTVTDTTGAAIPNATITLTNTANGSIRVDKSSGSGELNISAVPAGDYSAKIEATGFQSQNVNLTVVVTQVQTLSFKLAPGSEQQTVEVTAAAALVNTSDATLGETIEGKQITELPLNGRNALNLALLTPGVTQGAYGESGNDPSNRNGESGGSALSVNGTRPQANNFLLDGVDNNDGLQNIILFFPPVDGTQEFKVNTSVAPAQFGRAGGALVVASIKSGTNGVHGSAFDQYRSGKFAANPNYSFLGAPPVANPPYNRNQFGGSVGFPFLKDKLFMFGDYEGTRESLPGNSAYITVPTVKMRTGDFSELLNPGQTYGNFDTTFPACVPNAGTLNNNISGNSKGQIYDPQTCTPFQNNQIPMARLNTAAVNYLNAFPLPSRSDRALQNYLSQQQSAIKYNRFDARLDYSLTKKDLFFLRFSYDNSTNGATSQLGPTLPNNAGTSYVHARGYDLGYTRTFSPSIVNEARLAYNRDNYGYQPPNYGQNISADLGIVNANRNLETSGGALIGGSNDQLEYSGDYGLFAVPQNTYELTDTLNIQRGAHSLKVGGTYLLRQTQFFRPISGKGFFAIAYHGTDFTGWETSELLVGGVDNYAIGAQDGYFGNISNEDGVFAQDDWRVTPRLTLNLGIRWDLLTWPYEKHNQQAAFNPTNGTVMIAGQNGISRSIINQDYLNFAPRVGFAYDVFGDGKTALHGGYGLFYFPDYGGISNQLGQQPPFGGSATYYARNGYCVTFTGQTTLGNPYTCPGYTTGNSAKIALPLPGFPNFNPAAPPAGLGGLAVDRDNKHSRLQQYNLQLQQQLGSRDVLSIAYVGTHADRLSTYYPINSYNFNTTALPFPTLGGISLNEYNGISWYNGLQAHYEHRQGNALLTASYTWSHALDDSPDAFGAGSTVSIASNPFASYGNSAQDQRHIFSGSAVYNFPFGRGQAFGGNANRFMDLLIGGWQSNLVGLFQTGQPFDISTGVNSPGNRPDLIAPISYPKKIIGQWFNTAAFSDNIPTLNVSGTGVYTRVGTLGRNQVYGPGYRSVNLGVQKNLHFTDRISLELHGDAFNVLNTPEFTNPSSAVTSGTFGEITGTRQNSARQIQLTSRLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X732</accession>
    <name>E8X732_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_3858</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71141">
        <property type="protein sequence ID" value="ADW71141"/>
        <property type="gene ID" value="AciX9_3858"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3858"/>
    <dbReference type="HOGENOM" id="CLU_051175_1_0_0"/>
    <dbReference type="OMA" id="LFMPNIY"/>
    <dbReference type="OrthoDB" id="83676at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="384" mass="42331" checksum="7F2057EF12E23769" modified="2011-04-05" version="1">MHLKPPTYVDNAAVPEPREVLAVLTQHWKVIAFVTAAFLFFGVAASFLLVRPSYTSIVVFLSPHGSQTLKPIGSGLSAAMLNSPSLNDRIIQKLQLQTAWKLTTFADAREALKSQVQIEVSTYDVVKITVRDHNARLASDIANEYLNGLNALDTRLAESDAADRYGFLDRQAKQENDELRQAEDRLQELQRRSGLIDPSRQTAQAILNISQLHAVIAARAVDLQSMRRYASDTNPGVIQLRATIAQLERQLSDRQNDASPRAVGDIQIPAGNIADLALQHQRALREVTLHSNQSGQVMLQLAQARMNLMRTAPAVLVIDRAIMADYRSGPQRLLLWLASCWAGFFTACLYVFLGKAMALSGYDAASIRRLLRPKAGPGLNTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7E3</accession>
    <name>E8X7E3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiamine pyrophosphate TPP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_4429</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573096.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71377">
        <property type="protein sequence ID" value="ADW71377"/>
        <property type="gene ID" value="AciX9_4429"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4429"/>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_0"/>
    <dbReference type="OMA" id="EQRYNDI"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="7">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="8">
        <location>
            <begin position="407"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="560" mass="59997" checksum="9371B21DAC59B15A" modified="2011-04-05" version="1">MQTVGTYLATRLVEIGLKHHFAVAGDYNLVLLDQLLLNKDLQQVYCSNELNCGFSAEGYARACGAAAAVVTFSVGALSAFDAIGGAYAENLPVILISGSPNSNDAADRHLLHHTLGTHDFSYQLEMAKKITCAAVSITSAADAPSLIDHAIRTALREKKPAYIEIACNIAAQPCAEPGPISAVIGSEASDPATLEAAVKAALLFINEKKKPVILIGSKIRSAGAEKEAIALAEALGCSVAVMAAAKGFFPEEHPQFVGIYWGEVSSGCARELVDWSDGVVAIGAVFNDYSTVGWTALPSGPALMTADTNHISFDGHDFSSIQLRDFLQALTRKVSKQDGTMAEYRRLVKKATPEVAADPTAKLMRAEMMRQIRPLVTSTTTVFAETGDSWFNGTQLKLPLGARFEVEMQWGHIGWSIPSSFGYAVGLPDRRTLVLVGDGSFQLTAQEVAQMIRRKLPVIIILINNYGYTIEVEIHDGPYNNVKNWDYAGLMKVFNAQDGRGLGCTATNGAELAIAIKAAEANLDGPTLIECIIDRDDCTAELISWGHLVAAANARPPRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G5</accession>
    <name>E8X7G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4453</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71399">
        <property type="protein sequence ID" value="ADW71399"/>
        <property type="gene ID" value="AciX9_4453"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4453"/>
    <dbReference type="HOGENOM" id="CLU_205971_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5752" checksum="A8AD8CF607EF702E" modified="2011-04-05" version="1">MHLEDAMIAEVSRADAEREILLHQLDPADFFVEIGDRSTYTGAEVLGWLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7I7</accession>
    <name>E8X7I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4475</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71421">
        <property type="protein sequence ID" value="ADW71421"/>
        <property type="gene ID" value="AciX9_4475"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4475"/>
    <dbReference type="HOGENOM" id="CLU_2617048_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="78" mass="8564" checksum="C0967AC35DB66488" modified="2011-04-05" version="1">MQIVEPSIGHFSHTNPFIIGNFAPVTIETTACNLPVKGSIVPELEGRLLRSGSNSVQTLEHERNDCSWVQGGHEDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M7</accession>
    <name>E8X7M7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4520"/>
    <dbReference type="EnsemblBacteria" id="ADW71461">
        <property type="protein sequence ID" value="ADW71461"/>
        <property type="gene ID" value="AciX9_4520"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4520"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_0_1_0"/>
    <dbReference type="OMA" id="CDLPEIE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26601" checksum="5FC33D2DE737DBDA" modified="2011-04-05" version="1">MANDSFVSYLRVSTVCPGVSGLSLEAQRTAVAGFLNGGRWTHVREIVEIESGKRNDRPTLAEALALCKRRRATLVIAKLDRLARNIHFITGLMESGVDFLAVDMPEANPTMIRMMAVFAQHEAEAISSRTKAALAAAKARGTKLGGRRVSSEEFAVIAASGRRVSAKVRSAKAAATRAELLPVIAEIRGEGKGTLQQIAAELNARGEKTPRGGDWSPVQVMRVIGSRKPRPPIEMMPVSERMTTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7T7</accession>
    <name>E8X7T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4591</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71521">
        <property type="protein sequence ID" value="ADW71521"/>
        <property type="gene ID" value="AciX9_4591"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4591"/>
    <dbReference type="eggNOG" id="ENOG5033FFN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015388_0_0_0"/>
    <dbReference type="OMA" id="AMAGDIN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="306" mass="30581" checksum="968EBCC08AB046B9" modified="2011-04-05" version="1">MLFRSREETARNQTLYQGESLMKTEIVRRTAVVARAVAGLAIFGASVALTGCTTSGFALNGGTTTPPTGYAYLTGNWVFQTVPTAGSTPFSSLAGYVDEQSGNPGVNDLTTAALQAQQPSSCYLGASLIPLQGALQAAALGLRSFSVNAQFVTINATKDATATHLTGTYSIDGGCAGGAAGTITGTKYNVLTGTYAGSVTGSNPAQTLRLSLSQNTQGSGEGLFLESGSAVFNGFSCFSKGTLSAGAGTIIGNTVALTFTTDDPSGAKVILNGSVDSAADVLTISSGSITGGGCAGSLAASTLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7X6</accession>
    <name>E8X7X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573279.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71560">
        <property type="protein sequence ID" value="ADW71560"/>
        <property type="gene ID" value="AciX9_4630"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4630"/>
    <dbReference type="HOGENOM" id="CLU_189062_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="89" mass="9858" checksum="9E90DFE4E6123782" modified="2011-04-05" version="1">MLKAINTKLLIAILAALAVIGGLLVRQNGIRKDQAAAAARTAAVLEQQQRQAAADQKYREDEAKKVDTIRRSKSKMPANEQKTWNNYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y3</accession>
    <name>E8X7Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4637</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71567">
        <property type="protein sequence ID" value="ADW71567"/>
        <property type="gene ID" value="AciX9_4637"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4637"/>
    <dbReference type="HOGENOM" id="CLU_1537949_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18968" checksum="EBF02A65DF99B06F" modified="2011-04-05" version="1">MPGTEVLQPAPNYQLTRGEHVERLSRGEQTCTTAIPANLQSACQRPDVLLSYHVVLYCGRAARGSDHRSDAPVPGPSGSRRRSGIRCGGHKRADLRCRTAGAAQESDRTVLALAFFFVACFLMGKVSGAAGSLWSLEELLPRPAIKSSSETLKTSQRRSRERTEMPLPFSNPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV71</accession>
    <name>E8WV71_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0172</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578574.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0172"/>
    <dbReference type="EnsemblBacteria" id="ADW67246">
        <property type="protein sequence ID" value="ADW67246"/>
        <property type="gene ID" value="AciX9_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0172"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_9_3_0"/>
    <dbReference type="OMA" id="ESITRCA"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="113" mass="12183" checksum="71234FCC781C80F1" modified="2011-04-05" version="1">MSMKFKTRQVDGVTVLDLSGRITLGEGSVTLRDAVRDVLSKGSNKILLNLGDVNYIDSSGIGELVSAFTTVKNGGGELKLLNLTKKVKDLLQITKLYTVFDVKDDEASAISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV90</accession>
    <name>E8WV90_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0191</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0191"/>
    <dbReference type="EnsemblBacteria" id="ADW67265">
        <property type="protein sequence ID" value="ADW67265"/>
        <property type="gene ID" value="AciX9_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0191"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_3_0"/>
    <dbReference type="OMA" id="GGAMHLN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="396"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="592" mass="64593" checksum="1D2E24A90D0CFE01" modified="2011-04-05" version="1">MMTRKYSDLLAEWLVSLGYTHCFFVAGGNIMHLLESCSHRLTCIPVVHEVAAGIAAEYFNELQMGSKAFALVTAGPGLTNIVTAMAGAYLESRELLVIGGQVKVSDLSRGKVRQRGIQEIDGVAIARPVTEKSVLIEAPMDRSAFAETIRSGVHGRKAPVFVEIPLDVQGAQVEETMLNTSASEIRPGFTPVSPEVVRSIVEQIKRAKRPVVLIGGGIDRATIEPLLDSLTRLGVPLMVTWNGMDRIPASHPLYFGRPNTWGQRYSNILLQQADLLLALGTRLSLQQTGFNWQQFVPAGEVIQVDCDAAELEKGHPRVALPICGDANQVLIQLEKEDAGNHEEWVSFCRTVQSKLPLIEPVNHTGEGFLSPYVFASELSRLATPDDIMIPCSSGSAFTVMMQTFAQKSGQRIITNKGLASMGYGLSGAIGSAFAAKGRRTILVEGDGGFIQNLQELGTVMVNKLNLKIFLFDDNGYASIRMTQLNYFKGRYVGCDTSTGLGIPKWEPLFAAYDIPVVRLGPGYQDDPDFLSRFNAPGPAAFLVHIDPTQTYFPKISSRVTETGGMVSNPLHLMTPDLDEDTSSKVFHYLQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH6</accession>
    <name>E8WVH6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectate_lyase22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1364</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579747.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1364"/>
    <dbReference type="EnsemblBacteria" id="ADW68424">
        <property type="protein sequence ID" value="ADW68424"/>
        <property type="gene ID" value="AciX9_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1364"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610983_0_0_0"/>
    <dbReference type="OMA" id="WLVNEDG"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047487">
        <property type="term" value="F:oligogalacturonide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027946">
        <property type="entry name" value="Ogl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14583">
        <property type="entry name" value="Pectate_lyase22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233406" description="Pectate_lyase22 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase22" evidence="3">
        <location>
            <begin position="224"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="478" mass="52880" checksum="688170C8CA17664C" modified="2011-04-05" version="1">MNRIAARIALATTLLPLSALAQSTPPKTWVDKDTGHRVIRLTDEPGSSGFYFNNNAYTPDLKTMIYNAPDGIRGMDMVTRKTRLIVPNPPTPAGDNVARFRNGVHAIIAGRKTNSIFYTQTDPATKQSSIYKADVYTNQITKLATLPPGAPGVATINADETLAAGTMNDGPAVAPEYGANSVSPTGTPRVAPEAHGAQSGNLVQPDNKGEMMERRLASRQPLILYTVSLKPGDNSKITVLQHSTDWVNHLLFSPKDPQLLMYCHEGPWQKVDRIWMIHTDGTHNTLIHKRHIAMEIAGHEFWGLDGETIWYDWQPIKGQDFYLAGYDLSNGKRTAFHMDRNEWSIHFNLTQDLDLFTGDGGDKGQVAKAPDGEWIELFHPQMINTAGALNEPDFFQPGIFHSEHLVNMSHHNYKLEPNVRFSPDKSLVIFTSNMFGPSYVFGVETAVTKNMKPADLLSTPELGEKLNPGKPASTNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN9</accession>
    <name>E8WVN9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2538</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2538"/>
    <dbReference type="EnsemblBacteria" id="ADW69568">
        <property type="protein sequence ID" value="ADW69568"/>
        <property type="gene ID" value="AciX9_2538"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2538"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_0"/>
    <dbReference type="OMA" id="NVHDKHP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="36386" checksum="EBCEC5E807CC8C0F" modified="2011-04-05" version="1">MAMKQQTFASQSIFEKYGRKSRRELFLDEMEVVVPWPELQALVEPHYPKAGNGRRPVGLAIMLRTYFMQQWFNLSDPGVEEAFYESFTLRRFAGVDLGVAPAPDETTVLRFRHLLEKHDLGGAMLDAVNLHLAARGIRIETGTIVDATIIHAPSSTKNEKKERDPAMRQTRKGKQWYFGLKAHIGVDAKEGHVHSVATSAANVSDVHMLPDLLHGDERKVWGDGGYQGQTKAIRQAAPKAQDMTCKRTRFKNYVDEAAKKKNTTKSKVRAKVEHVFRVLKRVFGFDKVRYRGIAKNHHRLCANFALINLYLHRKHLAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVS9</accession>
    <name>E8WVS9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_3687</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581997.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3687"/>
    <dbReference type="EnsemblBacteria" id="ADW70688">
        <property type="protein sequence ID" value="ADW70688"/>
        <property type="gene ID" value="AciX9_3687"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3687"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_6_2_0"/>
    <dbReference type="OMA" id="GTTLYWW"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21161" checksum="E611004323C23F6D" modified="2011-04-05" version="1">MPFLRQFRAAPNLLTLLRLFIIPFLVINILDGRWTLAFGLIMLAGISDGLDGVIARWLKQITTLGLYLDPIADKLLLSTLFLVLTHVGAIPRYVTVLVFSRDLGILLIATLLFATNTLRNFRPSIFGKLNTFVQIIAVVGIMGGHVFAIPYLSTVTGLLLRAIAVLAPLSAAQYAWIVIQRVSTPVADAPTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW43</accession>
    <name>E8WW43_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0277</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67349">
        <property type="protein sequence ID" value="ADW67349"/>
        <property type="gene ID" value="AciX9_0277"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0277"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_0"/>
    <dbReference type="OMA" id="EKLVPWS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="321" mass="36400" checksum="EBCEC5F12F6E1F0F" modified="2011-04-05" version="1">MAMKQQTFASQSIFEKYGRKSRRELFLDEMEVVVPWPELQALVEPHYPKAGNGRRPVGLAIMLRTYFMQQWFNLSDPGVEEAFYESFTLRRFAGVDLGVAPAPDETTVLRFRHLLEKHDLGGAMLDAVNLHLAARGIRIETGTIVDATIIHAPSSTKNEKKERDPAMRQTRKGKQWYFGLKAHIGVDAKEGHVHSVATSAANVSDVHMLPDLLHGDERKVWGDGGYQGQTKAIRQAAPKAQDMTCKRTRFKNYVDEAAKKKNTTKSKVRAKVEHVFRILKRVFGFDKVRYRGIAKNHHRLCANFALINLYLHRKHLAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWC0</accession>
    <name>E8WWC0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579824.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1450"/>
    <dbReference type="EnsemblBacteria" id="ADW68503">
        <property type="protein sequence ID" value="ADW68503"/>
        <property type="gene ID" value="AciX9_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1450"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_0_0_0"/>
    <dbReference type="OMA" id="DDLPYWE"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="33484" checksum="7E254ADBCEB7A93D" modified="2011-04-05" version="1">MQPTVSFWPNGARLAVSFSLMFEGGGQPISGAPGFFEEPMEKGLPDLATNGVFQYGIYEGIPRILDLMDKHQVKLSSFMIGQAVDKAPDLAREIVRRGHEAGAHGRSWQNSYLLDRESERRFIVDGMESIQRATGQTPVGWNAYFVRNSPHTLDILQSLGFVYHIDEPSADQPFIIKLKGGDFVTVPYTLHLNDIASFTFVGWNPVAYEQALRDEFDQLYEEGAHRRRMMVIGLHDRISGHANRVRVLDRFLTYARSKTDVWFARKDEIAALALEHRDITPIYERGAPTTTGLPGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWH7</accession>
    <name>E8WWH7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2616</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2616"/>
    <dbReference type="EnsemblBacteria" id="ADW69641">
        <property type="protein sequence ID" value="ADW69641"/>
        <property type="gene ID" value="AciX9_2616"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2616"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="595" mass="65235" checksum="5265C776D1F33999" modified="2011-04-05" version="1">MAVVGAMGAFRFLLIKPILDNVLSASSSPDQVLKFRIPHTNTVVNLQSLIPSHFHNAWTVVAVALVASAVVKSVCDYLGTLLANKAGFGMITDLRNDLYDSLLRRSMAFFQKHTTGSLLSTLINDIERVQAAMSTVLSDFLQQLFTLIFMVGAVILVGGKLAWVLLLFLPVVISSARRIGRSVRKTTRKGQDKLAEIQNILHETITGNGIVKAFGMELWEMNRFRRAADRLLTANMRSVAVQSISSPLMDALGAVAIALLLYLGRQSILHGTSAGAFITFLAATIGLYDPVRKMPMFYNSFQQAVGASEEIFKFMDAQDDVREKKRAAVVKGFEKEICFNGVGFGYEEDGRRVPILHSIDLRVARGEVVAFVGPSGAGKSSLVNLIPRFFDVNDGAITIDGLDLRDVTIESLRKQIGKVTQETVLFNDTVRNNIAYGQPDIPLKKVQEAAKMALAHDFILRMPDGYDTMIGEKGVRLSGGERQRLAIARAILKNAPILILDEATSALDTESEAFVQAALANLMEGRTVFVIAHRLSTVRRATRIVVLEAGRIVEMGTHDELLANSGTYKRLYDLQFIGEMPTESAEAAWELEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK4</accession>
    <name>E8WWK4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2643</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580983.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2643"/>
    <dbReference type="EnsemblBacteria" id="ADW69668">
        <property type="protein sequence ID" value="ADW69668"/>
        <property type="gene ID" value="AciX9_2643"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2643"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282519_0_0_0"/>
    <dbReference type="OMA" id="TQFHFSI"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114584" checksum="E6F1DD7B87FA55E4" modified="2011-04-05" version="1">MSLGGGLFTRAAFSQIPSSSTVTTATPSGPTTTNPSGLSSPTPQASQEPATSAAVGAMGPIIPALSANLTQYQGLRVESIHYEGVEFDKSDRLTGELTQKVGEPFDADNVRQTTRRLFATGRYQNIAVRVVRNGDAVTLIFAGVARSYIGRIQINGVKEERLASLLEYGTQLNPGTAYSPAQLPAATEAVRQVLAQNGYYEPVVAVQTERDPVGNQVNVTYTVSVGPQARVGNIVISGTNPGISLATFRKKGKLKPKNKVTRETTSNALSNLRGVYQKQNRLEATLTLQKSTYDPATKRVNYEFQAEQGPVVKVLVDGIKISKSRLHLLVPIFEEGTIDNDLLNEGRFKIQDFMEQSGYSDAKVSFAVEGAASTTQTVRYTVDKGIKHKVVAVEVTGNKYFGSQLLVDRLAVHKADAYQRVGRYSTQLVKNDATNLEGLYRANGFNSAKVTSSIKDFDEAGGKNLKVARVAVTYTVVEGTQQKFGSVDLNGIDPSRKQVLSGLLGATPGQPFSLVQLSGDRDALLSWYVSNGFDQAKLEVKQTIEGEDKSKTDVAFNVIEGQQVFVGKVLESGVQHTRQSLVDQQTKVHAGDPLDQSALLETQRNLYNLALFNEVVAAVQNPDGDAEQKNVLLQITEAKRWDVTYGVGFEAQTGLPSRGIYSTAQGTTAAQQGKAGVSPRVSVDVSRINLRGTDNSLTLHTAYGLLEQIATLSFQDPHFRGNKNLALQISGGYTNVQDITTFAAKTLQADLRLTQKATRKDTFIYDFVYRRVEVDPNSLEISPDLIPQLSQPVRVGGPQVTWFHDTRTPSALDATKGSYTSVVDFYASSKVGSQTDFNRTDISNSTYYAFGKRKYVFARNTRVGFIANFGVNPNAGNAGCAGALVNTNASCNPIPLPERLYAGGATSHRGFPINGAGPRDLQTGYPVGGSGVFVNSLELRMPAPTLPVVGSSISFVVFHDMGNVFQQVSQIGPSFGRFHQPNVGTCKNLTGVNVSCNFNYFSHAIGLGARYATPVGPIRVDFSYNLNPPTYPVEPNSGVLNAPFVGTGSHFNFFFSIGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ1</accession>
    <name>E8WWQ1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0307</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578707.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67379">
        <property type="protein sequence ID" value="ADW67379"/>
        <property type="gene ID" value="AciX9_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0307"/>
    <dbReference type="eggNOG" id="ENOG5033J48">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246176_0_0_0"/>
    <dbReference type="OMA" id="FNILPMW"/>
    <dbReference type="OrthoDB" id="2191608at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="104" mass="11616" checksum="6A17B522A13DE730" modified="2011-04-05" version="1">MKKAISTFLQFLLFFVVFGVGSILGGLFDPTHLRWFVTHPTLTSTRYFKADGLLLAFAVYVLVILIEAARKRISTAAPWTTLAFLLALVIGFLSKFGFATHDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ7</accession>
    <name>E8WWQ7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="13" type="ordered locus">AciX9_0313</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578713.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0313"/>
    <dbReference type="EnsemblBacteria" id="ADW67385">
        <property type="protein sequence ID" value="ADW67385"/>
        <property type="gene ID" value="AciX9_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0313"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_0"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="310" mass="31745" checksum="793337EB67B82E96" modified="2011-04-05" version="1">MRPVVVVGSLNLDRSFRLAEAAAAGRTQTAIGYAEGVGGKGVNQAMAAARLGAEVRMMGCVGRDSAGEVLRRALGEAGVGVEAVGTCVEPTGTATILVGPDGENTIVLVPGANHVFGAEDVERQRGLLVGASIVLVQLETRMEVLAKVVEIAGSAEVPVMLDPAPAAKISAEVLRGLAWFTPNETEAEFYLRDTGWVGSAPGMEEQCRYFQGLGPRNVLLKLGGAGAAMLTEDGRFVRVAAPQVAVVNTTGAGDTLNGALAAELALGCGAEAALRFAVAAASLSTTRDGAAESQPTRSEVESFAVRANDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU0</accession>
    <name>E8WWU0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0346</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578746.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0346"/>
    <dbReference type="EnsemblBacteria" id="ADW67418">
        <property type="protein sequence ID" value="ADW67418"/>
        <property type="gene ID" value="AciX9_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0346"/>
    <dbReference type="HOGENOM" id="CLU_1956512_0_0_0"/>
    <dbReference type="OMA" id="PFHHSKK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233440" evidence="2">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="12154" checksum="A5A21985F792C5D7" modified="2011-04-05" version="1">MKLALALAALTLSLPALAQTQAPAQPQAPVRTQTATPQQAYPAAQGRSPGGDIGSGSGDIGKGAAGGAGQVAKGTGKGAVDLVTLHPINAAGNVGKGAAVGGKDVGVGAVKGTGKITKGVGRGIKHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX90</accession>
    <name>E8WX90_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetamidase/Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2708</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581047.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2708"/>
    <dbReference type="EnsemblBacteria" id="ADW69732">
        <property type="protein sequence ID" value="ADW69732"/>
        <property type="gene ID" value="AciX9_2708"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2708"/>
    <dbReference type="eggNOG" id="COG2421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_2_1_0"/>
    <dbReference type="OMA" id="PWGFTGI"/>
    <dbReference type="OrthoDB" id="228571at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230030" evidence="1">
        <location>
            <begin position="24"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="353" mass="37952" checksum="5DB5F84D1BB6526E" modified="2011-04-05" version="1">MPVCSRLIVAAATLFALAPFASAQQPQKLLATPQTIVWGNYNGMAKPALTVKSGDTVAIQTLSTCGPAARLMAAGVDRKDIPTYVDDIYSNFPATEKGPGGHILTGPVAIEGAKAGDVLEVRIQKIDIDVPWACNSFGAGRGFLPDDFPYSRTKIIPLDREKMIGHFAPGVDIPLHPFFGSMGIATPGGKSDSAPPWMNAGNMDNKEMVAGTVLYIPINTPGANFEVGDGHAGQGNGEVDITAMETQLTGTFEFILHKGSLTDPTRLVWPRGETPTQYIAMGFHEDLKRATEMAVRNMITFLSEQNPDHPHLSREDAYSLISVSCDVDITQLVDLPRVGVHVMCPKNMFTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG8</accession>
    <name>E8WXG8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0429</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578829.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0429"/>
    <dbReference type="EnsemblBacteria" id="ADW67501">
        <property type="protein sequence ID" value="ADW67501"/>
        <property type="gene ID" value="AciX9_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0429"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_0"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="97"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="203" mass="23163" checksum="2E5698C93D2B8605" modified="2011-04-05" version="1">MAFELPPLPYAYDALEPFIDEATMKLHHDKHHQTYVTNLNGAVEKYPDLGKKTPEELVKDLASIPEDVRKVVQNNGGGHVNHTMFWQIMKPQGGGEPTGNIGLQITTDFGSFEDFKKKFNETTAKQFGAGWGWLVFKGGKLEILTTANQDSPLSQGLYPILGNDVWEHAYYLKYQNKRPDYLAAWWSTVNWEEINKRFETAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXH2</accession>
    <name>E8WXH2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpiA</name>
        <name evidence="3" type="ordered locus">AciX9_0433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578833.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0433"/>
    <dbReference type="EnsemblBacteria" id="ADW67505">
        <property type="protein sequence ID" value="ADW67505"/>
        <property type="gene ID" value="AciX9_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0433"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_0_0"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="1681738at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="223" mass="23507" checksum="092EC71489A38F87" modified="2011-04-05" version="1">MTQDEAKAAVARRAVEFVEDGMRVGLGTGTTATMFIRALAERKPKIRCVASSDASFNLGAELGLDMMTLNELPEIDVYIDGADEVGPGLALIKGGGGALLREKIVASAAKRFVVVVDSSKVVECLGKFPLPIEVIKMALPLVLPKLEALGLEPKQRRAKSGDGPYLTDEGNFIVDCFVGKIADPVMVAAEVRAIVGVVEHGLFLGMAQVALVAGEDGVTEWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR6</accession>
    <name>E8WXR6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2737</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581076.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2737"/>
    <dbReference type="EnsemblBacteria" id="ADW69761">
        <property type="protein sequence ID" value="ADW69761"/>
        <property type="gene ID" value="AciX9_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2737"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_0"/>
    <dbReference type="OMA" id="YLYIAVI"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="463" mass="49046" checksum="F0E8A6FB2A0B4B18" modified="2011-04-05" version="1">MSKPQTERILLGAAALFFLLGCVILHAQQGHAVAAIALRWVAIGILAVFAARRRTLTPWIFVAMVAGAELGFDAPAFAVNLRVFSDIFLRLIKTIVAPLIFATLVVGIAGHGDLKSVGRMGIKSLFYFEVLTTIALVIGLLAINISKAGVGLSIPVAAGATETLAKVAPTHWDDFLLHVFPENIAKSVADGQILQVAVFAVFFAIALAGLSEEKRGPVMRLCESLSEVMFKFTNVVMYFAPIGVGAAMAFTVGHMGLGVLVNLGKLLMTFYLALIAFVLFVLLPVALLARVPILGFVKAVTEAATIAFATATSEAALPRAMESMEAFGVPRRIVSFVIPAGYSFNLDGSTLYLAMASIFVAQAAGIHMGWGQQLVMMGTLVLTSKGVAGVPRAVLVVLLATAATFRLPTEPIFVILGIDALMDMGRTMLNVVGNCLASAVIARWEGAFRTEPVSSVVHEGMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS2</accession>
    <name>E8WXS2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2743</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2743"/>
    <dbReference type="EnsemblBacteria" id="ADW69767">
        <property type="protein sequence ID" value="ADW69767"/>
        <property type="gene ID" value="AciX9_2743"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2743"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_0"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="5"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="403" mass="43391" checksum="71613E272A647B53" modified="2011-04-05" version="1">MSTLNRWWIALAGILLQMALGAVYAWSVFRAPLAKQFHWSISEVTLTFTIAIMVLGFASFFGGLWLKKVGPRVVALTGGALYGIGVFLASFSSIGLWWLYLTYGVIGGIGLGFAYIVPVAVLLKWFPDKRGLMTGIAVGGFGAGALVTAPIATRLIQSIGVLHTFAYLGIAFLIVTVAAATFMQNPPEGWQPEGWTPTQKQLVQEHARSFTLGEALKTWQWWALWLLLFLNTSAGISIISQEAPMFQEFARATAIIAAGMVGIVSIGNALGRVFWAWVSDTLGRRMTFVSMFVIQILLFWLLPSLHAVPIVTAISFIILMCYGGGFGTMPAFAADYFGPANVGSIYGLMLTAWGFASAFGPLLIAHLRQSSGTYASGLHIIAMIMAVSALLPLVVRPPAVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV3</accession>
    <name>E8WXV3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">AciX9_2774</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581113.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2774"/>
    <dbReference type="EnsemblBacteria" id="ADW69798">
        <property type="protein sequence ID" value="ADW69798"/>
        <property type="gene ID" value="AciX9_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2774"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_0"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="338" mass="35896" checksum="8E536F0CDD6CE913" modified="2011-04-05" version="1">MSLSLKPQVSVRAKITSVGSYVPPKLLTNQDLEKMVATNDQWITERTGIRERHIVEPGVATSDLAVEAAKACLAKRGVSADEVEVIIVATVTPDMMFPATACLVQDKLGAHHAWGFDLSAACSGFPYALQVGAKLIESGVHKKILVIGADVMSSVIDYTDRTTCVIFGDGAGAVLLEPCEPGEVGLVDYFHEIDGSGGVSLNMPGGGSLHPATAETVAAKMHYVHQDGGAVYKFAVRKMSEAAETVLTRNGITGKDLKCFIPHQANKRIILSTAERLGMDEECVVINIDRFGNTTAATIPLAMQTALDEGRLQKGDLVLLASVGAGFTVGATLLQWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY03</accession>
    <name>E8WY03_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578870.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67542">
        <property type="protein sequence ID" value="ADW67542"/>
        <property type="gene ID" value="AciX9_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0470"/>
    <dbReference type="eggNOG" id="COG3847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171854_8_0_0"/>
    <dbReference type="OMA" id="WRLRIWK"/>
    <dbReference type="OrthoDB" id="2065691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6242" checksum="1DF06F4FB58EA11F" modified="2011-04-05" version="1">MNKTKSFFFDLLQDESGQDLIEYALVAGLIGLGAVVAMTGLSGKIQSSFNSVGSSLTNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY33</accession>
    <name>E8WY33_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0500</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0500"/>
    <dbReference type="EnsemblBacteria" id="ADW67572">
        <property type="protein sequence ID" value="ADW67572"/>
        <property type="gene ID" value="AciX9_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0500"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_0"/>
    <dbReference type="OMA" id="LYREAPM"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="387" mass="41846" checksum="BC3BB1C1C6C8D365" modified="2011-04-05" version="1">MRADRARALTQLSDEERMLQESVRDFAGERIAPLVRQMDEAQTMDAGLIRELFGLGLMGIEVPEELGGAGGSFFDACLAIEAISEVDPAVGVMVDVQNTLCINALNKWGSDEQKKRYLPRMAKDTIGSYCLSEAASGSDAFALQTRATQRGSDYVLNGQKLWITNAKEAGLYLVFATLDPALGYKGITGFVVEKGTPGFSVGKKEDKLGIRASSTCELVFQDCVVGADQVLGEPGKGYKIAIETLNEGRIGIGAQMLGLASGAWGHAAKWAKERKQFGKALVEFQAMQFQLAEMATEIEMAKLMVYNAARLKDNGSEFLKEAAMCKYVASQVAEKTASLAVEVFGGSGFVKEFPVEKLYRDAKIGKIYEGTSFMQLATIAKLTLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE7</accession>
    <name>E8WYE7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2830</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581168.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2830"/>
    <dbReference type="EnsemblBacteria" id="ADW69853">
        <property type="protein sequence ID" value="ADW69853"/>
        <property type="gene ID" value="AciX9_2830"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2830"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_5_1_0"/>
    <dbReference type="OMA" id="AEHSWHF"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="192" mass="21693" checksum="43F49097A3943CCD" modified="2011-04-05" version="1">MQQIIDFILELDKLKAVTRKVKPLGLDRYENSAEHSWQITLLAVCLAPYAEAGVDLNHVVRMLLVHDIGEIDTGDTMVFVEGGWAERKADELEAVKRIFALLPEATGAEFLKLWIEFEAGETAEARFAHVADRAMPVLLNLSNRGQSWRENGISYERVVKRVRPEVEAGCPELWQYLEGRLEEARAKGLFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR2</accession>
    <name>E8WYR2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queF</name>
        <name evidence="2" type="ordered locus">AciX9_1699</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580067.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1699"/>
    <dbReference type="EnsemblBacteria" id="ADW68748">
        <property type="protein sequence ID" value="ADW68748"/>
        <property type="gene ID" value="AciX9_1699"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1699"/>
    <dbReference type="eggNOG" id="COG0780">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102489_1_2_0"/>
    <dbReference type="OMA" id="LYINSYR"/>
    <dbReference type="OrthoDB" id="1675155at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="15673" checksum="8B6141857545A0CA" modified="2011-04-05" version="1">MRTQNTGYTDDHAASGLDHVFPAIDVWANQFQGYEILVDDPEFTSICPKTGLPDFGILTIRYMPRKECLELKSLKEYLFHYRNLGIFQENIVNQILDDVVKATDPVWAVIKGDFRPRGGISTTVTATYPRPLDAKPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYR3</accession>
    <name>E8WYR3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580068.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68749">
        <property type="protein sequence ID" value="ADW68749"/>
        <property type="gene ID" value="AciX9_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1700"/>
    <dbReference type="HOGENOM" id="CLU_1803462_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="16164" checksum="60A6A0228F5FC331" modified="2011-04-05" version="1">MPAGGGLKPTSNPNRNRNRNRNRNRNGNRNGNRNRDRNGNRNRDRNRNRNGNGNGNGKCNSQIRGSFASLRMTAWNKQRQLRGFSASRRMTTKTNNGNCNCNGNGNCSRNCNCNRNCNCNGNRNRNGNRNRNCRYGGSSLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYS6</accession>
    <name>E8WYS6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580081.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1714"/>
    <dbReference type="EnsemblBacteria" id="ADW68762">
        <property type="protein sequence ID" value="ADW68762"/>
        <property type="gene ID" value="AciX9_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1714"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014693_0_0_0"/>
    <dbReference type="OMA" id="CPFRAFA"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019925">
        <property type="entry name" value="DNA_repair_protein_predicted"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03623">
        <property type="entry name" value="TIGR03623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="607"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="896" mass="98363" checksum="71020A87C368C0BD" modified="2011-04-05" version="1">MGGTRLYKQIMQSVTTLPPVIAEAISRGVTILTPGQRAARTLRLAYDLHQRASGIPTWTPPEIHPLDSWLTTLWHRLTVTGQADRLLLNPTQEHVLWRQIITSDPEVSGLRSPDSLASMAASAWRTLCLHNGRTRLPGSATSTDTRAFERWAQTFQRLCLRQAYLSPAQLPELLTATVNLPIPPAGLLLLDFDTLLPAHQTLFDTLSPVAHHQTTTPAPPHLHAAADPRSELLTAANWIAQTLSANPESRIAVVVPDLESRRPEITRIFAQTLSPELQRFPTPATPTPFEFALGQPLSHTALAATALNLLTFTLSPLPLDTISTLLLSPYLITPIEQLAAAEFDAFTLRQTRLLRPELTLEALLALLPATLPSLSARLRALHRTAKSDLPTQQSHAAWSDTFRALLESAGWTRTAPLDSLAFQTHRRFSSALDELATLDFDGTHPTAAAALATFTRILDQTIFAPESHNAPIQILGPLEIGAVPFDALWFLSAGDLTWPNPPSTSPLIPWQLQRALNIPGSDPTQSQAAAQTLTTRIAHSASQVIFSYAVQVDEAHQRPSPSVTALKLTPLKALEAHTTLAPQPYDIIPDQTTLPPLPDVPLRGGATILQLQAACAFRAFAEQRLFSSEPQPRTLGLDPRDRGNLVHKVMEELWSCIHDQGELKALTLPARDSLLADCINHALQRTDRLAQSPWDEAYLGTQRTRLLTLLRPWLDLEAARPAFAVRAREQADRHAQLGPLTLSLRMDRVDETDAGLVILDYKTGVAAPSDWLSDRPDAPQLPLYAVLTDQPEEPVAGIAFAILRAGDDLCLKGYATGDDVFGKTSRMNFPTMEDQLEDWRRVLTQLATSFAEGDTAVLPKSYPKTCAYCAQRILCRLNPTTLTDLNDEEPEEAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ6</accession>
    <name>E8WYZ6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2888"/>
    <dbReference type="EnsemblBacteria" id="ADW69911">
        <property type="protein sequence ID" value="ADW69911"/>
        <property type="gene ID" value="AciX9_2888"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2888"/>
    <dbReference type="HOGENOM" id="CLU_3168639_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="47" mass="5337" checksum="CD7B6D7BEC225B10" modified="2011-04-05" version="1">MSPPTYERELPTMHFLVVAAAFLLMVLFPCLLTMKPSVLDESLIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ9</accession>
    <name>E8WYZ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2891</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581229.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2891"/>
    <dbReference type="EnsemblBacteria" id="ADW69914">
        <property type="protein sequence ID" value="ADW69914"/>
        <property type="gene ID" value="AciX9_2891"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2891"/>
    <dbReference type="HOGENOM" id="CLU_2301867_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="112" mass="12189" checksum="17F19F55F1EDF570" modified="2011-04-05" version="1">MFSQAPRPARFDLNLALTFAGDEGVLEGHCVNVSASGMLAAFARPVELFTNGELSLLVGEFYVNVKARVARTQGFDAGLAFIIETENDRHAVRLLVEFATAQHQPERQPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ17</accession>
    <name>E8WZ17_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ordered locus">AciX9_2909</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581247.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2909"/>
    <dbReference type="EnsemblBacteria" id="ADW69932">
        <property type="protein sequence ID" value="ADW69932"/>
        <property type="gene ID" value="AciX9_2909"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2909"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_0_0"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="384"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="508" mass="54475" checksum="EF84191CE1342CDC" modified="2011-04-05" version="1">MILESIPEALTFDDVLLVPAYSDVVPTQVNTQTRLTSRIMLNTPLMSAAMDTVTESRLAIAMAQQGGLGIIHRNLSIVQQAGEVDKVKRSESGMIVDPVTISPDESIAAALDVMRRYKISGVPVTKNKKLVGILTNRDLRFVSVTDAPIDTVMTKTNLITVPVGTTLEEAEHILHQHRVEKLLVVNDDYELKGLITVKDIQKKLKYPNACKDEQGRLRVGAAIGATGDYLERAAALVENRCDALAIDSAHGHSSRVLESVREVKKHFPNVSLLAGNVATYEGAMALIDAGADAIKVGIGPGSICTTRMVTGAGMPQITAISEAFRAAGPRGIPIIADGGIKYSGDVTKAIAAGASVVMMGSLFAGVDESPGETILYQGRSFKAYRGMGSLSAMAQGSGERYFQGKEDMNEISVGERPNLTAREGSTQNRLAKFVPEGIEGRVPHRGPLEAMVYQLVGGLRSGMGYLGCGSIEELQQKARFVRISNAGLKESHVHDVVITREAPNYHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZA0</accession>
    <name>E8WZA0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0631</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67702">
        <property type="protein sequence ID" value="ADW67702"/>
        <property type="gene ID" value="AciX9_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0631"/>
    <dbReference type="HOGENOM" id="CLU_2699537_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="73" mass="8168" checksum="F8B590B41B131305" modified="2011-04-05" version="1">MMGHSGCPKGEDDRPAAVVNTEHPAFITTGFIMIVIGFIIQFFAVPEPKSISDLRREIKNLKMREAATRDHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZP5</accession>
    <name>E8WZP5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2996</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581333.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70019">
        <property type="protein sequence ID" value="ADW70019"/>
        <property type="gene ID" value="AciX9_2996"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2996"/>
    <dbReference type="eggNOG" id="ENOG5030DUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199145_0_0_0"/>
    <dbReference type="OMA" id="TDWTGFY"/>
    <dbReference type="OrthoDB" id="1715899at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234013" evidence="1">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="242" mass="26557" checksum="FE23E5D88B6DA269" modified="2011-04-05" version="1">MKRTLRYVFGVVGAASLACVMSVRAQAQKDYVGKYDVYAGFADINAPALGLNQPGFHTQIGINPRRWYSVGFDFSIASGSEVLTTSELPAALQAQVNGAQQQYIAFGLLPPNYQLRVNTDARTETYALGPQLIYRKYSKVALFLRPSLGALHESATPHPSDPFQQVVVAELAPRGTKTDWTGFYGVGGGGDFRMTQHFGLRMQLDAVYNHPFNDILANGRWTYRASIGPSFHFGKNVTGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZQ7</accession>
    <name>E8WZQ7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3010</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70031">
        <property type="protein sequence ID" value="ADW70031"/>
        <property type="gene ID" value="AciX9_3010"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3010"/>
    <dbReference type="eggNOG" id="COG4270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128738_4_0_0"/>
    <dbReference type="OMA" id="LIAWAWW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="120" mass="13078" checksum="FDA521D0DFCE41CC" modified="2011-04-05" version="1">MSGFQIGRVILAVVFVVAGVLHFVLTPVYVRIVPGYLPSPVLLVHISGICEVLGGIGLLVPRVSRVAAWGLVALLVAVFPANVTMVLDTGRFPGIPLWAAWVRLPLQLPLIWWAWIYTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZU1</accession>
    <name>E8WZU1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579080.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0682"/>
    <dbReference type="EnsemblBacteria" id="ADW67752">
        <property type="protein sequence ID" value="ADW67752"/>
        <property type="gene ID" value="AciX9_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0682"/>
    <dbReference type="eggNOG" id="COG3494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085042_0_0_0"/>
    <dbReference type="OMA" id="CKPQQDI"/>
    <dbReference type="OrthoDB" id="1305058at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010415">
        <property type="entry name" value="LpxI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043167">
        <property type="entry name" value="LpxI_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041255">
        <property type="entry name" value="LpxI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06230">
        <property type="entry name" value="LpxI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17930">
        <property type="entry name" value="LpxI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LpxI_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="LpxI_C" evidence="1">
        <location>
            <begin position="148"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="288" mass="30433" checksum="C57EFB844D99E636" modified="2011-04-05" version="1">MSPESGVGRLGLIAGNGRFPFLLLDAARAHGLDVVVAAIKEETDVEMDERAALDAGVRVHWMSLGELSKLIETFRAEGVTRAVMAGQVKHKQIFSSIRPDWRLAKLLLNLRTRNTDMLLGAVAKVLGDEGIELISSTAYLEPLLATVGVMGARMPTEDERKDIEYGMTVARGIAGFDLGQTVVVAAQACVAVEAMEGTDATIARAGELFRTLGDGDATLSRALTVVKVAKPNQDMRFDVPVVGVPTIAAMKDAGATCLCVEAGRTLLFDRAAMVAAADAAGIALVGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X011</accession>
    <name>E8X011_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1861</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1861"/>
    <dbReference type="EnsemblBacteria" id="ADW68907">
        <property type="protein sequence ID" value="ADW68907"/>
        <property type="gene ID" value="AciX9_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1861"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052026_0_0_0"/>
    <dbReference type="OMA" id="HVTYVRY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="413" mass="45198" checksum="EEACE77066ED8561" modified="2011-04-05" version="1">MRAGDLRVLIVAEHASKRFGGEAILPYHYFRVLRSRGVDAWLIVHERTRDELITLFPNELDRLRFVKDMTLQKIFYQVGKLLPRRISEATFGLANQLLTQFAQRAMVLELVTPSAVVHQPIPVSPKFPSLMAGLGAPLVVGPMNGGMNYPAAFRGAEAWWSRGVIALGRSFSNVVNAVLSGKRNADVVLVANERTRAALPSGLRGRVLEVVENGVDLEQWPAGVGDRVHEPRFLFIGRLVDWKALDVAIEALGAVPGATLDVIGDGPMLDSWRGMATGLGLAERVRFHGWLTQEQCAEWLAGACALVLPSIYECGGAVVLEAMAMGKPVIATAWGGPADYLDESCGILIPPTSREAMVSGFAEAMRLLANDAEACTRVGEAGRIRVLEQFDWEKKVDRMMEIYRAVLPGLYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X037</accession>
    <name>E8X037_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="10" type="ordered locus">AciX9_1887</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580252.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1887"/>
    <dbReference type="EnsemblBacteria" id="ADW68933">
        <property type="protein sequence ID" value="ADW68933"/>
        <property type="gene ID" value="AciX9_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1887"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_2_0"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="9">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="24372" checksum="714B7CF674DAE921" modified="2011-04-05" version="1">MKGLYAIADVGVLARRGMGLRVFAEGLKAAGVGVVQLRDKDGSPEGVLAGARVLREVFAGTDSLLVMNDRVDLGLLAGFGGVHVGQGDLSVEDAKAVAGQSESQRAQRKDEEDTERKWVVGGSTHTEDEVRVADVGAADYVAVGPVFATGTKADASPVVGLEGVRRARALTGKPLVAIGGITLANARSVVDAGADMVAVITGLFVPGRTVESVAWEFGKICVEVEREKTQTRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X053</accession>
    <name>E8X053_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Argininosuccinate synthase</fullName>
            <ecNumber evidence="6">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">AciX9_1903</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the argininosuccinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580268.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1903"/>
    <dbReference type="EnsemblBacteria" id="ADW68949">
        <property type="protein sequence ID" value="ADW68949"/>
        <property type="gene ID" value="AciX9_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1903"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_1_0"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="446" mass="49494" checksum="8ACC0724F7D46671" modified="2011-04-05" version="1">MSVILESLPLGQKVGIAFSGGLDTSAALHWMKQKGALPYAYTANLGQPDEADYEEIPRKALEYGAEKARLIDCRLPLVREGIAALQSGAFHITTAGVTYFNTTPIGRAVTGTMLVTAMKEDDVNIWGDGSTFKGNDIERFYRYGLLVNPNLKVYKPWLDATFIDELGGRAEMSAFMQASGFAYKMSSEKAYSTDSNILGATHEAKDLELLSTSMKIVAPIMGTPFWNEEVAIKKEEITIRFEEGFPVSLNGQDYPDPVALLLEANAIGGRHGLGMSDQIENRIIEAKSRGIYESPGLALLFIAYERLITGIHNEDTIEQYRDNGRKLGRLLYQGRWFDPQAIMLREAAQRWVAKPVTGSVTLELRRGNDYTILATDSPNLTFHPERLSMEKTESTFSPRDRIGQLTMRNLDITDTRAKLLTYAQTGLLTLSKGSEMPHLTSGKEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X090</accession>
    <name>E8X090_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="10" type="ordered locus">AciX9_3051</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3051"/>
    <dbReference type="EnsemblBacteria" id="ADW70071">
        <property type="protein sequence ID" value="ADW70071"/>
        <property type="gene ID" value="AciX9_3051"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3051"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_2_2_0"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="OrthoDB" id="1371775at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="9">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="8">
        <location>
            <begin position="200"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="528" mass="57918" checksum="7AD238A7A6C75447" modified="2011-04-05" version="1">MPVDDPIPSFLSLRAGKGKPRKGAGAGAKYKANPEQPMFAFEPGPVIVPEPVKAPVGPRVYAPIVLTPPEPSVVAKVREPILYTVRQLLNEIRQSVERSYEGTLTVEGEISNCRPAASGHVYLTLKDGDAQLSVVMFRRQASLLGFKPKDGLSVEVRGRISVYETRGQLQLIAETMRPRGEGALQLAFEQLKKRLAAEGLFDAARKKPLPPFPHCVGIVTSANGAALTDIINVVRRRHARLNLLVYPATMQGPQCAPSVMAGVRWFNKHPDRVDLILIARGGGSFEDLAGFNDEALARVIAESELPVVSAIGHEIDTTIADFVADLRAPTPSAAAELITVAQHRIGERISALEARVQRAGRYHLMHARQRLFRLSAEQVLARLRDSISLRHQKVDELQFRMVAAFARVERLRSGRVIALEARLRRQDPTVRVAMAKRRLEIAVARMDRAGKDMVARRGVRLERASARLEALSPLAVLNRGYAIVYGADGGILRDAGEAGVEQVIRARLARGSVRARITEIETTEKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B9</accession>
    <name>E8X0B9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581414.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3080"/>
    <dbReference type="EnsemblBacteria" id="ADW70100">
        <property type="protein sequence ID" value="ADW70100"/>
        <property type="gene ID" value="AciX9_3080"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3080"/>
    <dbReference type="eggNOG" id="ENOG5033DN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1684089_0_0_0"/>
    <dbReference type="OMA" id="MASANHN"/>
    <dbReference type="OrthoDB" id="2030087at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="16796" checksum="61D31A4B6CA519B4" modified="2011-04-05" version="1">MDAGRFGRALGQGAREAAKAAVQAAEAAAAPSPAPSRRTARPAPATPIIERARETVSQSSHHTVQTAQGIKRGGKRFGEAIWGPFAKLSSVLILEVTGVLFGMFALVAASEVWKGRHDFHAAAAEQRHEIFAIIMLAVFGYFTLSSFLRASRRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I6</accession>
    <name>E8X0I6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0781</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0781"/>
    <dbReference type="EnsemblBacteria" id="ADW67850">
        <property type="protein sequence ID" value="ADW67850"/>
        <property type="gene ID" value="AciX9_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0781"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313482_0_0_0"/>
    <dbReference type="OMA" id="VCEYITP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234232" evidence="7">
        <location>
            <begin position="21"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="214"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="800" mass="81711" checksum="51561902F5C2D6A6" modified="2011-04-05" version="1">MRLSNLLPALMLLATTLAPAQQPSLTTFAPLAGHRPTWAIPTNDRGPIPDATPIPLILALTRSPERQSAFDQLLIAQQNPASPSYHHWLTPTQIGEQFGPTPQDLEAVTTWLTSRGITIEAITPSRTYIQATAPAAIVSAAFQTSLHTYTLGTRTTQAPTSDPIIPAALTPVIAYISGLTQTPFHTSLHQTAPIPVAQTNLSPDYTLSSGAVHLLAPTDFAIAYDVTPVYTAGTTGTGQRVAIVGGSRLLPSDLTTWESLSGLPAAQPTYIVPTGTGFADPGMTSNTDQGEGTLDFERVYGTAPGVSVDQIISTNWLNGTVTENLILYAINTVRDPILSLSFGACEAQQTPAYINYESSVFAQAAAQGIGVFVSSGDAGAAGCESQGTPPATQALSISDLCASQYVTCVGGTQFSDLTATASYWSTTNNATNHSSILSYIPEGAWNEPTSTTPATPFVVGASGGGKSTVIAKPTYQAGTGVPADAARDVPDISFSASTHNGYFSCLAYAGADCTKSLLAFGGTSASAPSMAGVAALLNQKLGAAQGNLNPLLYRLAASTPTAFHDPTPATSGVSSCTTTTASTCNNSTPSATALTGGLAGFPLTTGYDQVTGLGSLDVSAFLTAATPAITPTPTFTLVPTTTALSTTAGTPITDVINIATTSNFTGQIAFTCAVSPVTSITPTCTITPASLAYPATTSTTLTIGSTAPHANLSPRAAIAFAAIFLLAITRRRKTLRPALASLATLLFLAGCGSGGSNGTSTPTTLTGGTTPGTYTVTVTASTATPTTTLSISTNLTLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N1</accession>
    <name>E8X0N1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5916 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580301.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1936"/>
    <dbReference type="EnsemblBacteria" id="ADW68982">
        <property type="protein sequence ID" value="ADW68982"/>
        <property type="gene ID" value="AciX9_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1936"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016090_1_0_0"/>
    <dbReference type="OMA" id="YDQVWDS"/>
    <dbReference type="OrthoDB" id="120742at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045670">
        <property type="entry name" value="DUF5916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19313">
        <property type="entry name" value="DUF5916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233570" description="DUF5916 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5916" evidence="2">
        <location>
            <begin position="296"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="799" mass="88616" checksum="9E0BD47B3EFB1238" modified="2011-04-05" version="1">MKFKGPSTVVASALSVLLWLSASAHAQVGSQEPGQPKPSVVAQTQPRSIPLADASVPLLDHPLTLADFPAMAPRPDLKDKLGHLTQFIQNTPVDGAAATEPTEVYLGRTNNTLYIVFLCFAKHPELIRTHLARRENILKDDFVTVNLDPFQDRQRGVMFQVNPSGVQADASWTEANGYDYSYDQVWDSDARITSKGYMALIALPFRSLRFPPTGSDWGAVFWRNIPRNSENDFWPRVSANVSGQLSQEGTLHLNGLAGVTGSHNIQLNPYALGQSEHTLQTQDPNNPAFSTRHLEGTAGGEAKAILKDSIVFDATINPDFSDVESDQPQFTVNQRYPVYFPELRPFFLENASYFATPLTLLYTRNIIRPEFGARVTGKIDRYNLGILAIDDREPGEAVPAGDPLAKARAGFFVGRLSRDLGKGSNVGLTYTDEEFGGGANRVGGIDFTWRADSHWTILGQGVESSTRQNNPASAAFVFPTGYHAGPATDIQVQRNGHSFSLNDEYQDISKGFTTLAGFLQTSNIRSDHLHSTYQWYPKHSLAQSIGLETNQNIAFDHAGNRVYHYSTFDPFVLLPNNIVIAPLIGQNSDTVGPQNGYPLPASRNFTENFGGFVARGQPWSQLNFNVQAIRSGNVNYNPPPGQSPFLLNQETVQALITLNPLRQLTDDNTYLLDRDHSVKDGQLVYETQVFRTKLNYQFTRAWSARLIVEYDSTLANPAQTSLTRTKQVQTQALLTWLPHPGTVVYIGYNNDLQNYNHQLCSVITGTRTCNPGRPILPRGPAYLNDGRQFFIKASYLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q1</accession>
    <name>E8X0Q1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1956</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1956"/>
    <dbReference type="EnsemblBacteria" id="ADW69002">
        <property type="protein sequence ID" value="ADW69002"/>
        <property type="gene ID" value="AciX9_1956"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1956"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108879_4_1_0"/>
    <dbReference type="OMA" id="GTHDRSN"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="12807" checksum="058DA0FF300F774F" modified="2011-04-05" version="1">MAERAKRPCNKPGCPELVSSGYCAVHQDATKAHDRWRGSATTRGYDHAWSKVRRLALKRDSYLCQHCLLAGRVTPALDVDHIRPITSAPQLRLDLSNTQSLCRACHALKTAKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0W2</accession>
    <name>E8X0W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3133</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3133"/>
    <dbReference type="EnsemblBacteria" id="ADW70146">
        <property type="protein sequence ID" value="ADW70146"/>
        <property type="gene ID" value="AciX9_3133"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3133"/>
    <dbReference type="eggNOG" id="ENOG5030NC9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089264_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019619">
        <property type="entry name" value="DUF2490"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10677">
        <property type="entry name" value="DUF2490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="28142" checksum="95FECE7D886EDA41" modified="2011-04-05" version="1">MLATLIFLSDTSAAQMGGTSRSAWFSYFGDQPISTHWAIHAEGSCRRTFDLSQFEQVELRPGLTLLENRSHQSLVAYTFFRTHATDDGSFGPTPADQRQVEKRLFEQHQIALRLRNREGSVPELIQRFRIEQRWRATGPNGGEFEPTAFSQRARYRLTAKIPFSNSTSTGHYFVAYNEVYTNASLKRDLLNADVTYGALGTRMGRDWALEVGYQFRFAPTSLGVTGPQDHSLQVYLLSTAPFRHRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0X3</accession>
    <name>E8X0X3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3145</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581470.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3145"/>
    <dbReference type="EnsemblBacteria" id="ADW70157">
        <property type="protein sequence ID" value="ADW70157"/>
        <property type="gene ID" value="AciX9_3145"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3145"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_0"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="303" mass="32450" checksum="C4D6BB268318D2CB" modified="2011-04-05" version="1">MTKTPFDSKSTADVVLANLDLSDRTILVTGCSGGIGLETIRALSARGARIIGVARSLDSAQRACARLKSPAAAIACDQSDLRSVERAANTIAERYEKVDAIVANAGITGASTVQTRGSVEMQFLVNYLSHFHLINRLVPKLPDHSGRVVVVSSSASKNQAPKDGILFDDLDGHTHYSASKFYGQSKLALAIFATELARRLGDRGIAVNSLHPGAVKGTDLNRNLTFPLSLVLSVAQLFFKSPEQGAATQSMLVASPVVEQISGKYWEDCQIAEGSKYLSDTAMASRLWQVSNELVARTLKMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X109</accession>
    <name>E8X109_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0807</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579200.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0807"/>
    <dbReference type="EnsemblBacteria" id="ADW67875">
        <property type="protein sequence ID" value="ADW67875"/>
        <property type="gene ID" value="AciX9_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0807"/>
    <dbReference type="eggNOG" id="COG4119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118065_0_0_0"/>
    <dbReference type="OMA" id="HMGGPLW"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="17781" checksum="5AC95F04537E640E" modified="2011-04-05" version="1">MSKNTKRSAGLLMYRITAAQPEVFLVHPGGPIWAKKDAGAWTLPKGEYDQEEEPLLAAQREFLEETGFTPAPPFHSLGSIRQKSGKLVIAWAFAGDCNPDHLVSNTCFIEWPPRSGKRIEIPEIDRGRWFSFDSGRRFIREEQIPLLDKLEQETLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X134</accession>
    <name>E8X134_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0832</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0832"/>
    <dbReference type="EnsemblBacteria" id="ADW67900">
        <property type="protein sequence ID" value="ADW67900"/>
        <property type="gene ID" value="AciX9_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0832"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_1_0"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="5">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="16897" checksum="312D372E232B32BD" modified="2011-04-05" version="1">MAVEDGKLSHYDESGQAHMVDVSAKGETRREAVARAFVELSEAVLKALPQNPKGNPLEVARFAGIQAAKQTSTLIPMCHPLALSFVDVQATVVAGGVEIEATAATVAGTGVEMEAMVAASVAALTVYDMTKALDKGIRIREVVLMRKSGGKSGEYRRAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X149</accession>
    <name>E8X149_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579240.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67915">
        <property type="protein sequence ID" value="ADW67915"/>
        <property type="gene ID" value="AciX9_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0847"/>
    <dbReference type="eggNOG" id="ENOG50338T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_755988_0_0_0"/>
    <dbReference type="OMA" id="GAIMEFV"/>
    <dbReference type="OrthoDB" id="2170880at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="40348" checksum="EE84966289FCCF68" modified="2011-04-05" version="1">MQRLNPIDAIAPAFTRTHQTLFQPFKAGRTWKLCASSYLAFAGSMFFPVPLAFAALPWHASSSRPALLAYLALATVFTLIFLAFFYLGARMELVHFEMVVTRGKFIAPMWRRYSRTIWPWLGLKVGIGIVLTAVMAPILLTTGRRLFTGIASMPKATPGQPPDPALFHAFMAQMIGFYAMFFLVFFVLKLFATLLNDFVLPFYTLEQLPLLAALSRGVDVIAADPVQIILYLLMKFALSIIGFVMQYFANLIIFVPFGIIIFIGAMIAGITGAHKGSPAYILLIVGGILLYILFIALTMYWSIGTFGYLLTLLEAYGIYFLGGRYPMLGDILEPPAPPAYTFTPPPTPPSPGEDDGPSLPMDPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X172</accession>
    <name>E8X172_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0870</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0870"/>
    <dbReference type="EnsemblBacteria" id="ADW67938">
        <property type="protein sequence ID" value="ADW67938"/>
        <property type="gene ID" value="AciX9_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0870"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_0"/>
    <dbReference type="OMA" id="TLITDWD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234260" evidence="2">
        <location>
            <begin position="43"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="701"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="784" mass="83999" checksum="0B49D1B04235AA1D" modified="2011-04-05" version="1">MMEGTLTLRIVNSMQMTVCRQRAISAALIASMNLLAVPFVQARAVAQSAPSSVKAGGDARETRFVNELLGQMTLEEKIEQMSQVALNTPDGAKAEAFAQAGVGSFLFITDPVRINKLQHIAVEKSRLHIPILFGFDVIHGFRTVYPVPLAMAASWDPKAVEKGQRMAAREASAAGVKWTFAPMVDIARDARWGRIMEGAGEDPYLGARIAEAQVHGFQGSSLSNADSIVACVKHLAGYGAAVGGRDYDSSDISENDLQNIYLPPFHAAEKAGAGTFMTAYMDLNGVPAAGNKWLVRDTLKGQWGFKGFVVSDWDAVHSLVVHGFAKDDADAAARAANTGIDMEMTSHDYTDHLAAEVKSGAVTVVTIDEAVRRILSVKYRLGLFEHPYSDPALANAQFVNAEQRAAARAAAIRSAVLLKNDGNVLPLQRPKSIAVIGPLAASKVDIGGSWSLASHPADNVTVLEGIRRRYAGTPDAVKFSKGVEIERGNWSIFDEQFPEDKPTLHTDAEKKAAFDEAIALVKASDVTVMVLGEAQNMNGERAARQSLDLPGQQEALLEAAQATGKPVVLVLLNGRPLAINWAAGHVPAILEAWYPGTEGGNAVADLLFGDAVPGGKLPVTFPRSAGQEPLFYARYLTQIPHEPDTRYWDGSSAPLYPFGYGLSYAKFTTTNLKLGAASVAAGGPLQVSVDVKNDGAVAADEVVQLYTHQRAGSASRPVRELKGFERVTLKAGETRTVTLTLDTKELGFWSAATRRFGIEPGTFDVWVGDSSASSENHGTFELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X193</accession>
    <name>E8X193_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2002</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2002"/>
    <dbReference type="EnsemblBacteria" id="ADW69047">
        <property type="protein sequence ID" value="ADW69047"/>
        <property type="gene ID" value="AciX9_2002"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2002"/>
    <dbReference type="HOGENOM" id="CLU_3328447_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="38" mass="4594" checksum="649E32F50FA8A728" modified="2011-04-05" version="1">MRTKEQKDAKFTKMRHIRFQQIKVEEMSSGVNWAVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F7</accession>
    <name>E8X1F7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VirB8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3181</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581504.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3181"/>
    <dbReference type="EnsemblBacteria" id="ADW70192">
        <property type="protein sequence ID" value="ADW70192"/>
        <property type="gene ID" value="AciX9_3181"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3181"/>
    <dbReference type="eggNOG" id="COG3701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037320_0_0_0"/>
    <dbReference type="OMA" id="LLCGSMW"/>
    <dbReference type="OrthoDB" id="1030619at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007430">
        <property type="entry name" value="VirB8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04335">
        <property type="entry name" value="VirB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="VirB8" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="30151" checksum="7CC6D58318012B2D" modified="2011-04-05" version="1">MSAHTAHIESSLTPEQALLTDRIGNEVYSSHYAERKTYRFIIGCGAVLLCGSMWLNLSLAHRPVANRYVRIDEMGRAQAIQYSDLNYSPREGEVRTYLTDWANYRFTISRDLIAKKYPLNYYFLSQPLAAQLMGSDNQSHLVSQVTSGQVESSDVQVRNVTITSMSEETVQGARVDRGTALITLDKIYSEHTSHEPRTEHWLLSATYYLNPKQVSDQAKIFPQYEFVNPLGLTITEFHENRVSVDIQAPGTTAANPNAIVQRTTGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1J2</accession>
    <name>E8X1J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3216</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581539.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3216"/>
    <dbReference type="EnsemblBacteria" id="ADW70227">
        <property type="protein sequence ID" value="ADW70227"/>
        <property type="gene ID" value="AciX9_3216"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3216"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="GETVFFY"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="28562" checksum="BB4924FF8B24F9E6" modified="2011-04-05" version="1">MLELRNVSKTYRSIPAVEDVSFLLKEGEVLGYLGPNGSGKSTTVKMVIGMIRPTKGEVLFDGREIHHDLAQYRSQLGYVPEEAQVYTHLSGLEYLQLIGRLRGMREGPLEDKARTLLQLLSLEAAQYSPMSGYSKGMKQRVLIAAALLHDPRLLVFDEPLSGLDAVTSRLFKDLLVVLAEEGKAILYISHVMEVVERVCDRVIVLAKGKVVADAAPRELTQLMELPTLESVFAQLVKQTDTMTVARDVVDTMKVLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T6</accession>
    <name>E8X1T6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0938</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0938"/>
    <dbReference type="EnsemblBacteria" id="ADW68005">
        <property type="protein sequence ID" value="ADW68005"/>
        <property type="gene ID" value="AciX9_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0938"/>
    <dbReference type="HOGENOM" id="CLU_212076_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6488" checksum="D840EA0A36D2A9B4" modified="2011-04-05" version="1">MDGMPVLYFLADTFINVFGITQPTEKTRKQAAFFILGLGVLVLIAVSIAGYLIHLSMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U9</accession>
    <name>E8X1U9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Queuosine synthesis-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2065</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580427.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2065"/>
    <dbReference type="EnsemblBacteria" id="ADW69110">
        <property type="protein sequence ID" value="ADW69110"/>
        <property type="gene ID" value="AciX9_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2065"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_0"/>
    <dbReference type="OMA" id="DKPAQPC"/>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="279" mass="30653" checksum="D1EA1331F637F473" modified="2011-04-05" version="1">MLLAEKSALLYQTLQDLGSVLIAYSGGTDSAYLAYAAHQTLGDKMLAVIADSPSLPRAELAQALAFTATHNIPTHILQTDELEKPDYIRNDARRCFHCKDTLFAAMESYRATYAFAHLAYGMNLDDQGDFRPGQQAATLHNAVAPLVTAHLTKKEIRLLAQQANLTLWDKPASACLSSRIEYGRPVTRENLSQVEQAEAALHTLGFPQVRVRHHGDLARIEIAREDLPRALSLAVLDQITAALKPLGFLYIALDTQGYRTGSMNAALIPYITPAERIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V3</accession>
    <name>E8X1V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2069</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580431.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2069"/>
    <dbReference type="EnsemblBacteria" id="ADW69114">
        <property type="protein sequence ID" value="ADW69114"/>
        <property type="gene ID" value="AciX9_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2069"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27082" checksum="7B7C8A5091EC660D" modified="2011-04-05" version="1">MGHKLFDLSGKVAVVVGGTSGIGLAMAIGLAEAGANVVASSRRQEQVDEAAALIEAQGVETLRITSDVGNRASLQALLDGTLKQFGKVDILINCAGKIKREPTLTVSEETWDDIMNTNVTGTLRACQIFGKHMLERGSGKIINIASLNTFVSLKEVTAYAASKAAVGALTKSLAVEWSSLGVTVNAIAPGVFRTALNQKLLDESERGKELRMRTPMGRFGKTEELVGSAIFLASEASNFVTGEILVVDGGFLASGVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1W0</accession>
    <name>E8X1W0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2076</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580438.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2076"/>
    <dbReference type="EnsemblBacteria" id="ADW69121">
        <property type="protein sequence ID" value="ADW69121"/>
        <property type="gene ID" value="AciX9_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2076"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024503_1_0_0"/>
    <dbReference type="OMA" id="FPYANSP"/>
    <dbReference type="OrthoDB" id="837523at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234281" evidence="2">
        <location>
            <begin position="23"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="674" mass="71088" checksum="B2DF58DC50109DAD" modified="2011-04-05" version="1">MTKQMKAAMAAMLMVGTLPMMAQTSETKTVKVAPGQTKTTVIHRKNGATDTVVSEGTSTGVKHTSRKRVVRKGAKAPVESATAREIRELKERQTAQQAQIDALTAANAAKDAALVQAQQTAANAETQAQAATQQAQSVSSTVQATSDQVQALKSNVSDLQTTNVGLAQTISANKVELQEKIDSPLAIHYKGVTITPVAFFALEGVWRQRSINSDINTPFNTTPYPGSNEAHISEFNLSGRQSRLGGLFEGNAGKYKLSGYFEADFLSAGTTSNENQSNSYTLRQRQFWGKAETQGGFAVTGGQTWSLVTEDGKGTDVRTEKLPNTVDPQYMVGYSWARQPGIRLQRRFGDATKGAVTVAIAAEQAQIQLGTTANAPANFIFGGVGTSGGLLNAGGTGATGAAGTSGGDLATYTNDVAPDIIAKVAFDNKYGHVELGGLARFFRDAYAPLVLNANGTTNSVSSNLLKNTKTGGGVFGSARVSPSKYADIAVQAMAGDGTARYGSSQLGDVTVHPDGTLAPIHNYHGMFSLETHPTKKLDVYGYYGYEYNQRTVYTSPAGVLTGYGVLNANDSGCNTLTIPTTGVGGTGGVNGAPGTVGTCASPTKNVQEGMIGFTYKVVNSPKYGRLQYQATYSYLQRTSWEGLLSGTFGTTSAQFTAAHATNNMIHVGMRYYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X210</accession>
    <name>E8X210_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ordered locus">AciX9_2127</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580487.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2127"/>
    <dbReference type="EnsemblBacteria" id="ADW69171">
        <property type="protein sequence ID" value="ADW69171"/>
        <property type="gene ID" value="AciX9_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2127"/>
    <dbReference type="eggNOG" id="COG1273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048975_0_0_0"/>
    <dbReference type="OMA" id="HAMRWPD"/>
    <dbReference type="OrthoDB" id="1724780at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="69"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="334" mass="36815" checksum="B1B8CDDB151A628D" modified="2011-04-05" version="1">MARPYWTGQITISLVSFGVKLFVATEAKGEIHFHQISRSTGERVRQQKVLASAQEARESAPDDAPMAASSMVKKDEIVKGYEYTKGQYVIVEPKELSELRVPSKHTMEVIQFVDAEEIDPEYFEKPYFVVPENDAQAPAFAVVRQALRDEKKIALSKIAFGGREHVVAITPTQDDSLGGMMAYTMRYSEELRDPKEYFRDIKKPAVDEDSLDLAKQLIKRKSAKFDPAKFVDGYEVALKELVQAKIDHAPIPKDEAPAPKKSNVVSLMDALRKSIASPASEDTSDHEAHEEAPAKKKPAAKHAAAPAKGIALVKSGKALKAATKTAKAPKRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X264</accession>
    <name>E8X264_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_3296</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581619.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3296"/>
    <dbReference type="EnsemblBacteria" id="ADW70307">
        <property type="protein sequence ID" value="ADW70307"/>
        <property type="gene ID" value="AciX9_3296"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3296"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_3_2_0"/>
    <dbReference type="OMA" id="LTEFWHR"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="47901" checksum="0E7E9E12907B6E24" modified="2011-04-05" version="1">MLFVELRFFLFFAVVLAIYWSLRSNDHRKWFILFASYYFYGSWDWRFAAMLLALSAADWFFALRISQTEARRPRKLYVIASLTMNLSVLAFFKYFHFFTGSAIALAEALKFHLDEPTLKIILPVGVSFFTFQSLSYTIDVYRNEIPAVPSLRDYLMFSSFFPQLVAGPIVRPKYFVPQMDGLRSISLTDVKAMMYLFLLGYIKKVCIADNLSPFVDQVFNHPAAYSAFSSINATWLYTIQIFCDFSGYSDMAIAVAGLLGYKLVLNFDAPYLAVSIQDFWRRWHISLSSWIRDYIYISLGGRMKWRILTYRNLLITMLAGGLWHGAAWTFVAWGGAHGASQVIHQEFKRHFPITERQQPWRNLAGWFLTLNFVCLCWILFRSPNFPVAWLMIRRYLFPFAAQAFSGPQTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X273</accession>
    <name>E8X273_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3305"/>
    <dbReference type="EnsemblBacteria" id="ADW70316">
        <property type="protein sequence ID" value="ADW70316"/>
        <property type="gene ID" value="AciX9_3305"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3305"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="PAIWTIQ"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234292" evidence="1">
        <location>
            <begin position="29"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="55438" checksum="53C0D7D6E85C4ED9" modified="2011-04-05" version="1">MENQLTRRTFGTLAGAALALSSIPRALAAVGRSHVESATADTGDLTSLTLAEAAAKLKARQISSTELTEASLARINIYDAKLDAFITVMKEKALAAAAQADTEIRAGMYRGPLHGIPIAAKDNIDTAGTRTTGASQLFEDRVPTEDAPVIARLHAAGAVLVGKTNLHEFAMGGGETSYWGPARNPWNLLHNTGGSSAGSGAAIAADLCYAALGTDTAGSVRMPASYCGVVGLKPTYGLVPIRGFIPLTVSLDHCGPLTRTVEDTAIMLNVMAGYDKLDTTSVEHAKEDYVSGMKQPVRGFRLGLPVGHFDTLQPDVRKAVMEAIALLTKMTAGAKEVSLPPPGNASTVGALGETYAWHDPYFKNQSAKYMVQERRRLEMAQTNHVWSVDYIHALWELQMLRRTIDDAFTDVDLVVLPTMRVVAPTIQELQKRGAETKPLDPWIASDCGYFNAYGLPAISVPCGFSQSGLPIGLMIAGPHFAESKVLALAHAYEQATDWHKRKPPLTPETVVPEIPAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X276</accession>
    <name>E8X276_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581631.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3308"/>
    <dbReference type="EnsemblBacteria" id="ADW70319">
        <property type="protein sequence ID" value="ADW70319"/>
        <property type="gene ID" value="AciX9_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3308"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="IRCPSAW"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="59295" checksum="AD7B714867D0A04C" modified="2011-04-05" version="1">MTKLTRRGFNFMCGTALVAETFSAAWPRISMAAMANTPDPDKLTAMTLTEVSGMIHMKTITSTELVKALLDRINLLNPKLNCYITVMGKEALAQAATLDAEQKAGKFRGPLHGIPISLKDNIDTAGTRTTAASPMFKDRVPTEDAEIVRKLKLAGAIILGKLNLHEFALGCTGDISYFGPSRNPWNLAYVTGGSSAGSGAAVSATLAYGALGTDTGGSIRCPSAWCGIVGLKPTIGLVSIRGIIPCSADLDHCGPMARTVEDVALMLTQMAGYDSLDIFSVPSTPADYVKEMTQPVKGFRLGTPQSFYDHVEPEIEKAIKAALEVLTSLTAGVTSSAPLWSELPGGAPGDSEFYHHDLIERYGLNYMLPTRTRFERMENPTPGAKVATAADDARAHQKLLTTRRMIDASFKDFDLVVVPTTRNLAPTINDSLANETKLSKAPASSGSRLEGVNGKVYDWFAPGGGCTNTAPFDAYGIPAISLPCGFTESGMPIGLMIAGPHFTEGKVLALAYAYQQATQWHKKLPFLNASTVVPPIIESGSSEAKIMPEAKPGVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N9</accession>
    <name>E8X2N9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3327</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3327"/>
    <dbReference type="EnsemblBacteria" id="ADW70336">
        <property type="protein sequence ID" value="ADW70336"/>
        <property type="gene ID" value="AciX9_3327"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3327"/>
    <dbReference type="HOGENOM" id="CLU_1088883_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="28390" checksum="304085E8C901A58E" modified="2011-04-05" version="1">MTRDPQLAPKDPSCTAILRPVVATACYSEHTDILDTKQARLALLELGWSITLPTNHAETGLYRALLSFADRDGHVAQTFHEIARRHKQKKTAFTKTLASLAEAKWLNVTKVGRCKKIRLDLQRFCLFALFDTDQLFSRDEAWIITQHSGHQVPAQRMNEGRRSASAGLFVTLAPPPPAPMLVVRDERKAMQFDTEDKPSAGMGCQRCKAAGHFCQSRGWAGEEPLCLECGSNLPCERSLITRPLAVDSLEARYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P2</accession>
    <name>E8X2P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3330"/>
    <dbReference type="EnsemblBacteria" id="ADW70339">
        <property type="protein sequence ID" value="ADW70339"/>
        <property type="gene ID" value="AciX9_3330"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3330"/>
    <dbReference type="HOGENOM" id="CLU_958985_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="290" mass="31343" checksum="C7A911183643A7AA" modified="2011-04-05" version="1">MATAKLPVRPLAPAKKTTGKTTKVTSRGPKTASLRASAAARKHSSGIKPETAKKVTQAPARTSPAAPHAAPVSQSNPITPYVLRPSDRQFIWYVTRVGNRFMESATEGVLTDDLQSAKVSTRLKEQELLTSLGQINGKDTWDAVPVIESLKVSRSGVVSGTQASNLLPELTSNWASSRWHNLALSESAAAEAKNDETIFGHGLELKLSAMWPALVARYREEEADQIAGDDSEIHDHALMMLVGRVFYAGVTAGRREQGSRNRFDELILDNPFHMTIRDASTASGRAGEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2S4</accession>
    <name>E8X2S4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3363</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581683.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3363"/>
    <dbReference type="EnsemblBacteria" id="ADW70371">
        <property type="protein sequence ID" value="ADW70371"/>
        <property type="gene ID" value="AciX9_3363"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3363"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028597_0_0_0"/>
    <dbReference type="OMA" id="AHYTSGD"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233610" evidence="5">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="558" mass="61396" checksum="E4A984B442400A16" modified="2011-04-05" version="1">MQRCAVWAGVLAICGVMGAQEPVSIQVDLSKPVGAYKPVYSWFGYDEANYTTAPDGQKLLRELHDLSPVPVSIRAHHLLTSGDGVAELKFSSTNVYTEDANGKPVYDFKILDGIFDAYKAACVRPMVELGFMPEALAADVPGRTEPYQVHYPKSTISGRSNNPPRDYKKWGELIRVVTAHLVERYGKEEVLRWYFEVWNEPDIDYWHAPAEDYWKLYDYAVAGVRTALPGAKVGGPASTSPRSEKARLFLKNFLDHVDTGSSAADGKRVPMDFITFHAKGSPKIAAGKVTMGIASELRDADEGFKLIAGFPRFKSLPIILSEADPEGCAACSSKVEPANNYRNGTLYPAYTADALKGLFELQDRHGVNLLGMLSWSFEFEDKEYFEGFRDLATNGVDKPVLNVFRMFGLMSGSRVAVTSSGRVDLDAKLAAGVREKADVDALATKGDRSAAVLVWNYDDIDGKAAAAKTTVSIGGMPAGVTRVLLEHYRLDDTHSNSYTVWKGMGSPQKPTEEQYKELQASGRLEMLTSPEWVEVKGGVMEVKMSLPRDGVSLLRVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T9</accession>
    <name>E8X2T9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3378</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3378"/>
    <dbReference type="EnsemblBacteria" id="ADW70386">
        <property type="protein sequence ID" value="ADW70386"/>
        <property type="gene ID" value="AciX9_3378"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3378"/>
    <dbReference type="eggNOG" id="ENOG502ZB8S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508912_0_0_0"/>
    <dbReference type="OMA" id="YAQVPAF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="540" mass="60837" checksum="1F8DC27CB668B1D3" modified="2011-04-05" version="1">MGHRRIMLVCMTPRAVTSEHEQTPEQLAATLDNYLAEYPAAVVMEDGKVLFDMREAKYTLGTEHGRCTLHLWGEERNLVRRVSGAALRDKVLRLTTHKFGQAKPQTLEVAGDKDRRTPSTREATRVRYVKVLERALGRQFEGWKPDAFRTAMDLEKSFGPAYARGLLVQGQKSWAVIGVNEEEAQTTVDGILTLGILWLESCRTAGDGRRTVQGLKLVVPRGMGALTLSRMAWLNGDAAQWELWELDQREETLELRDAADHGNLQTRLVHAPNEAAARERFAASAARVMGMLPEGMGAVTEQRIRSGTEVAFLLHGLEFARVRMGATGESFNRVEEISFGAGANETLLADENEGALRELVARLYERRSGAGDKRDPLYRMQPERWLEGELRRDLTLIDTKLDARHVYAQVPAFAAADRGMMDLLSVSEDGRLAVLELKADEDMQLALQGLDYWVRVRWHHLQNPDPVSGLGEFQRHGYFGDVRLSGVGPRLYLVAPALRVHPATEIVLRYLSPRVEWMLVGLDERWRSKVKVVWRKRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y3</accession>
    <name>E8X2Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1054</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579440.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1054"/>
    <dbReference type="EnsemblBacteria" id="ADW68117">
        <property type="protein sequence ID" value="ADW68117"/>
        <property type="gene ID" value="AciX9_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1054"/>
    <dbReference type="eggNOG" id="ENOG50335ZH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147880_0_0_0"/>
    <dbReference type="OrthoDB" id="2090150at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="136" mass="15471" checksum="BE1C7041E15F7AFC" modified="2011-04-05" version="1">MSNHSPAVARYLRRIAIASAAYVLTVFLTFHVFYHGRLPLPAAIGLATIPSIPIIAMIVIVALYLKEEKDEFQRELFIQSLLWGAGFTLALTSFWSFVHLFAHFPPVDGFHVFVIFWIIVGISDFFLRLKYRAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Z9</accession>
    <name>E8X2Z9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1070</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1070"/>
    <dbReference type="EnsemblBacteria" id="ADW68133">
        <property type="protein sequence ID" value="ADW68133"/>
        <property type="gene ID" value="AciX9_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1070"/>
    <dbReference type="HOGENOM" id="CLU_1793773_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="16331" checksum="A3B0D760C29ED31B" modified="2011-04-05" version="1">MRSNTRMKKLLEQLEIDPGEKLKEVIGQAPEIILIDGCVFLADVCANCKAIRLEQFPDRTGYECLINHTHHRVGRGKKALTRVFEYIAGIRRSLRSLGGENFMIIIAVAKGEATVRFHQSRPGEVWLTDDLELYKHEAIMTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X344</accession>
    <name>E8X344_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2226</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580584.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69268">
        <property type="protein sequence ID" value="ADW69268"/>
        <property type="gene ID" value="AciX9_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2226"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="MAVHRET"/>
    <dbReference type="OrthoDB" id="1729227at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230618" evidence="1">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="260" mass="28422" checksum="83416DFD8B58A8F7" modified="2011-04-05" version="1">MKMKLLAGLVLAAALRITSAQTPGPSSGQMPKSAHPTFDIVTIKPSDPDSHRQGIGYHGRQVDATGQTLKSLMMFAYGVHGKQIVDEPAWVSSVKFNIVGVADIPGEPSLPQMQEMYRKLFTDRFGLQLRHGKRELSYYAITIAKGGTKVLKAKDGDDASPDQTGEGHGYMEMRFTANLMSDFALGMNYFADRPIVDETGLQGRYDFTLKWTPDTATPTESSPVPGLFTAMQEQLGLKLEPKKGMVDVLAIEKVQQPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X345</accession>
    <name>E8X345_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="10" type="ordered locus">AciX9_2227</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580585.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2227"/>
    <dbReference type="EnsemblBacteria" id="ADW69269">
        <property type="protein sequence ID" value="ADW69269"/>
        <property type="gene ID" value="AciX9_2227"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2227"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_1_0_0"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="239"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="34660" checksum="538403512327C6E3" modified="2011-04-05" version="1">MTQIRIGSRGSQLALWQANHIAAELRAHGHQVEIEVIRTTGDRMQQPGFVPPPGLDGKGIFIKEIEDALLDGRIDLAVHSYKDLPTTIDPRFTIAAVPPRADARDAFVCEPYWALHTLPHAGRIGTTSPRRRAQLLALRPDLTFVELRGNIDTRLRKLEEGACDALVLACAGLDRIARTESVHQRFDVDELTPAPGQGALALETRSPAHALDTEDPTRDPAIYKAIRALEHPETRFATDAERAFLAEMGGGCELPLGAHCLSTSGVYRLYAQVLSPDGEYMVQTTLDRHPEEPAAALGQRAAEILKAQGALDLLSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X358</accession>
    <name>E8X358_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">anmK</name>
        <name evidence="2" type="ordered locus">AciX9_2241</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580598.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2241"/>
    <dbReference type="EnsemblBacteria" id="ADW69282">
        <property type="protein sequence ID" value="ADW69282"/>
        <property type="gene ID" value="AciX9_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2241"/>
    <dbReference type="eggNOG" id="COG2377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_0"/>
    <dbReference type="OMA" id="GQTIRHE"/>
    <dbReference type="OrthoDB" id="736294at2"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="389" mass="40493" checksum="D8C833BE61C309BA" modified="2011-04-05" version="1">MVVAGVMSGTSADGVDVAVVRVSPGAPTPKLKVIGHESFAYSEDVRAAVLRAMDAKEVSVAELSRLNWRLGEVYADCVEKTAAKVGKKIGLVSMHGQTIYHQGVAEEYLGAPVRATWQLGEAAVVAERMRVPVVSDMRPADLAAGGQGAPLVPMLDFCMFRSATKNRVLLNLGGIANVTAIPAGAGLDGLLAFDTGPANMVVDALMFKLYGRNYDCGGQTAARGRVLAGVVDEVMKDGYFSALPPKSCGREQYGAAFVARVHEACVAAGGKKADVIATATEITVRSVVEAYAKFCWSHLGQRAPLAKATELIAAGGGARNAYLMKGLTARFAELGVKVLAMDEMGVAAEAKEAAAFALLGWLSWFGMTGNVPSATGAKRGVVLGKVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X384</accession>
    <name>E8X384_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="5" type="ordered locus">AciX9_2270</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580624.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2270"/>
    <dbReference type="EnsemblBacteria" id="ADW69308">
        <property type="protein sequence ID" value="ADW69308"/>
        <property type="gene ID" value="AciX9_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2270"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_0"/>
    <dbReference type="OMA" id="GWARKYS"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="78"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="205" mass="22927" checksum="DD2A1E895F37147A" modified="2011-04-05" version="1">MTTPSQETTSNGRPTATPQQNDRYFFGTLDSFGKNQEKLREVNWGYDQPEGIVLASLDAAINWVRKNSVWPMTFGLACCAIEMMSMGGSRYDIARFGAEVFRPSPRQSDLMIIAGRVSQKMAPVIRRLYEQMPEPKWVISMGACATSGGVFNNYALLQGVNQIIPVDIYVPGCPPRPEQLLYAITLLQEKIQSERGTVRRTLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3V9</accession>
    <name>E8X3V9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69387">
        <property type="protein sequence ID" value="ADW69387"/>
        <property type="gene ID" value="AciX9_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2350"/>
    <dbReference type="eggNOG" id="ENOG502ZAIX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896536_0_0_0"/>
    <dbReference type="OMA" id="QKGTQTM"/>
    <dbReference type="OrthoDB" id="1194570at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230206" evidence="1">
        <location>
            <begin position="28"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="318" mass="34167" checksum="04816DAA11BC57D8" modified="2011-04-05" version="1">MNLFKRQKLSLALAAFTLVTPFFAAQAAELSNDGKAAIPHDVQQVIVVDYRAMQNSPAAMSLKDRVLPPELKRLETALKTSGLKVDQDAEILAFASFRAGEGTRIVGIAQGQFHTGAIMANFTKNKTKATALRNNQIYPLGSGGMSVCFLNQTTMVFGDKEALKAALDARDGVTANFLTNTDMVNEMASVDTKAVWSLLDQKGTQTMMKGVLGEASQLADYDTVKNRMKSAHYAMDFANGVKFDMAVVMSDTITAATIATLMKGVAIMKKNNGSPMEKTALDSTIIDSNSGTLTVDYSSSDSQFASLLTSPLFQSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X406</accession>
    <name>E8X406_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581825.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3509"/>
    <dbReference type="EnsemblBacteria" id="ADW70514">
        <property type="protein sequence ID" value="ADW70514"/>
        <property type="gene ID" value="AciX9_3509"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3509"/>
    <dbReference type="eggNOG" id="ENOG5033DKB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170201_0_0_0"/>
    <dbReference type="OMA" id="WFLILET"/>
    <dbReference type="OrthoDB" id="1936679at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="254" mass="26439" checksum="FFE3B8F77B12FEC8" modified="2011-04-05" version="1">MSTSQSGLQMVGTCHRCGGELAAHAVTDESGLFCPHCGAPQILLPEYMRPEPVPEPLAVTPTTGTIPPPLPQAIDWRNALICGGAVALVAAVLTVLGVISSFASLINFVWVVSGGVATVAVYQKRRPDALMNGRVGARIGLTAGLMLIVAIGLALATSGVVARFGLHRMASFDAQVAESVQTMQVQMQASMEEQKQSRDVQEKVIGMVNSPEVRAGIAVVYLGLLGAIVVLLGMGGGAFAGMLGARRQGVRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X422</accession>
    <name>E8X422_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3525</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3525"/>
    <dbReference type="EnsemblBacteria" id="ADW70530">
        <property type="protein sequence ID" value="ADW70530"/>
        <property type="gene ID" value="AciX9_3525"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3525"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="1">
        <location>
            <begin position="546"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1233" mass="131020" checksum="87FBAAA67C22A990" modified="2011-04-05" version="1">MCECAEYKGICGAVVGVESIRIGLIRVQKTRTTSFPSNQPFLIFFDLLLIRFDLKRSCLPAEFAFLEFVLNARYLAPHTLLLSVALAVPGTCAWAQAAGTGTIQGTVTDKSGAVVPNAKVTAVSQDTGRTAAQQTSSAGTYVLPALPPGDYSVTVELKGFSPVHQEHVIVNAISVVGLDLSLQAGGAGETVTVTATPSDLNTENGALDTTIPNSTYTALPVAMNGGPKSPLGFLSLVPGVASGDFGVENINGGSSNSSYLYINGLPLTTSEMQGDARNVNGATSTEVIDQFQIISSGVPAYYAGQGITNLVTKSGSNQLHGHVYENIRNTAFDAAGYFSTVTPVEHQNEYGGSLGGALVKDRFFFFGNLDRFKISNGNPPIFYNLPTAAERSGDFSALSVPIYDPASTVCNNGVCTRTAFSGNVIPAARLSSISRQLQSYLPATQNNAIQNNFASSLEGGTTQNMYLGKLDGAINSRQHAFALFQYGKNSPIGLPPNGGPQLPLPYTSSRTALEVIWLGQVGHTWTITPHVINVFGAQFNRFNTPFTSPTNGGGYLGKAGLTGLPSGAPSDNFPSVNFLGPNAPTLWASNNNTENSNTVANSFVYQDNLQWVRGRHSMTFGGQIIAQQEQQTIPNFLSGFNFSNNETAGFAAVNGVSSIDATTGNAYASYLLGAVDNAALYDTSVAETGARYRDYAVYAQDDWKITQRLTVNVGLRYIIAKPFVESENRNSWFNPALPNAAVSNYPGAVQFAGNGTDSCHCSTQVDTHYLTFDPRVGFAFSVTPKTVVRGSFTINHFNAGALGGNAQSQGTGLLGYVAQPSPNTPDSGITPAFNWATGFPAYAKPPIFDPTLNAGYNSTTGATGGNVTYNRPDTAARSPYTENWNLTVEQAFTPSLTLQISYAGSQSHFIPINGGVGIYSDQLDPKYMVLGGLLQQSLSPAVLAQAQTIVPTAKVPYANFVGTLGQALRPFPQYNSIYDPFADFGNASYHSLQTRLQQRTSHGLYFLASYTWSKSINNTGAVIAGAEAAPRSAYNLRQERAVAVEDIPQILSIATVYRLPFGRGQAFANSGIANAILGGWSISGIVQYQSGTPLGPILASCLVPYTGGCYADYGKGLTARINGAYGSGGSPSTTAYINRSAFADPASFTFGNTPRTLAFGLRNPWSLDEDVTVGRDLRITDRWKVRVQADAFNVFNRTVFGGIQTNIDSTNFGAVTLQSNSPRKLQLEGSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X430</accession>
    <name>E8X430_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3533</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581849.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3533"/>
    <dbReference type="EnsemblBacteria" id="ADW70538">
        <property type="protein sequence ID" value="ADW70538"/>
        <property type="gene ID" value="AciX9_3533"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3533"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_0"/>
    <dbReference type="OMA" id="SQGANQY"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="398" mass="42865" checksum="FB13A93A4E9C8E95" modified="2011-04-05" version="1">MPTATKNLHLSELAPRTVQSEIRAMSVACDAMGGVNLAQGICDTDPPEIVTEGAQKAIRDGHNIYTRLDGIPRLRKAISGQLARTHGIEADPEREILVTCGASGAFEAAVKALLNPGDEVLLFEPFYGYHAAMLRGNGCVPVPVAMTVSGEGEWRLDLEAVRAAVTSRTRAMMINTPSNPAGKVFTRTEIEGLAQIATERNLFVFTDEIYEHFVYGAARHLSPATIAGMRERTILMSGFSKTFSVTGWRIGYLVADAKWTPSIGYFHDLTYICAPAPLQHGVADGVEQLPASFYSGLATEHEVKRAMLVDALRKAGLTPHVPDGAYYILADCGPLLKGANAAEKARDLLRRTGVAAVAGSAFFRAGGGGENLLRFCFAKKDADLRDACARLERLAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X464</accession>
    <name>E8X464_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ordered locus">AciX9_0033</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578453.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0033"/>
    <dbReference type="EnsemblBacteria" id="ADW67124">
        <property type="protein sequence ID" value="ADW67124"/>
        <property type="gene ID" value="AciX9_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0033"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_0"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="45372" checksum="14CDBAF6DC7ED757" modified="2011-04-05" version="1">MPIDLNATLSAADPEIAAQIENEVNRQHEGLEMIASENFVSRAVLEAAGTVFTNKYAEGYPGKRYYGGCEFADVVEDLARSRAKKLFGAEHVNVQPHSGSQANAATCMTLLTPGDTILGLDLAHGGHLTHGHKLNFSGKLYKIAGYQVSKDTETVDYDELEAQAERERPKMIIGGGSAYPRQFDFPRLRAIADKVGAYLMVDMAHFAGLVAGGAHPSPIPHAHVVTTTTHKTLRGPRAGMILCGQEFAAGIDRSVFPGQQGGPLMHIIAAKAVAFKEALQPEFAQYATQTVTNAKVLAEAIAEKGFRIVSGGTDTHLMLVDVFQKGMLGSEAEHALGEAGITVNKNAIPYDTNPPMKPSGIRIGTPALTTRGMKEAEMLVIAGWIVRALEQRSDPAALAKIRGEVLELAEQFPLYEYLRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4D8</accession>
    <name>E8X4D8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyacyl-CoA dehydrogenase NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1202</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579588.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1202"/>
    <dbReference type="EnsemblBacteria" id="ADW68265">
        <property type="protein sequence ID" value="ADW68265"/>
        <property type="gene ID" value="AciX9_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1202"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618204_0_0_0"/>
    <dbReference type="OMA" id="EDVMPAK"/>
    <dbReference type="OrthoDB" id="1551041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="62"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="186" mass="19888" checksum="652B8F8022492DDF" modified="2011-04-05" version="1">MTAPEISPSKIKVAIIGAGTSGRHFALACATAGFSVVLEDVMPAKLRHAESDFSSLGLTVGLALTIEDAVREADIAVDFVPDDLESKLEIYSMLDRMAPPKTILCTPSQVLSITDLASCTYRPDRCIMFRGDPIPASPVRLLLAAATSPATQALAHRLFTTLGHPVHPEPDPDLPQLLKNMNTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E3</accession>
    <name>E8X4E3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1207</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579593.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1207"/>
    <dbReference type="EnsemblBacteria" id="ADW68270">
        <property type="protein sequence ID" value="ADW68270"/>
        <property type="gene ID" value="AciX9_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1207"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="RFFAEPY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="346" mass="37849" checksum="4A7389147171BC50" modified="2011-04-05" version="1">MKSSSKRSSAQKTDIHDVAAHAGVSIATVSRTLNHVPTVDAALAARVWKAVAELDYLPNTQARALVSGKSRLLGLIVSEITNPFFPELIQEFERIAVDQGYEILIGSTSHDPKKMDTCVRRMLERKVDGVAIMTFGFEEIVLDRLIADEIPLVFIDVASKHPRSGVLSVNYREGIQEGVQHLAALGHRKIGFISGPLHLRSAQARKSAFLESMQSAAVPINPKWIVEGDHTLEGGRDAMQTILSQKALPTAVMCSNDMTAIGVQHAVFEARLRIPEDLSLIGFDNIHMAEYTIPPLTTVQMSCKDLAQKAVRILLSHLSPEGGKGEIEITIGTRLIVRQTTGQPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4K8</accession>
    <name>E8X4K8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2381</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580734.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2381"/>
    <dbReference type="EnsemblBacteria" id="ADW69418">
        <property type="protein sequence ID" value="ADW69418"/>
        <property type="gene ID" value="AciX9_2381"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2381"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314866_0_0_0"/>
    <dbReference type="OMA" id="LGHSIYM"/>
    <dbReference type="OrthoDB" id="1332589at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="212" mass="23847" checksum="E07F886099DFAC48" modified="2011-04-05" version="1">MGLFGSKSSGSGSRPDGSRVQRHSSGWIELAKHLKSEESLRILDIGPTSASNINFVTNLGHSIYMANLVDEAAKPEWVVPKSEGDSESVFDVDRFLHQNLDFSGRHFDVVTLWDTLDYLPEAFVQPIVDRVFEVMQPGGRLLAFFHAKPTGDETVFARYHLTESDQIDLQRMGGHPILHTHTNRQVESIFKGFAAYKFFLAKDALREVLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V0</accession>
    <name>E8X4V0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3585</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581900.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3585"/>
    <dbReference type="MEROPS" id="S12.012"/>
    <dbReference type="EnsemblBacteria" id="ADW70589">
        <property type="protein sequence ID" value="ADW70589"/>
        <property type="gene ID" value="AciX9_3585"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3585"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_7_1_0"/>
    <dbReference type="OMA" id="YAGNTPK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234374" evidence="2">
        <location>
            <begin position="25"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="406" mass="43051" checksum="A44DDE76CDCA9919" modified="2011-04-05" version="1">MPKPKLIALLALAALLPALSRAQALPDLKSADTLGQSLLERSGSTGLVLVVVRDKEIYVHGFGETAPGSHQAPTATSLLRLCSLTKIFAADLLIKLVQDKTVRLDDPLKSYAPVNATVPDKQARPITLGDLATHTAGLPREMAPTPRGSGHFTFPNHAQRWNWLPTAHLITVPGTAALYSNLSFDLLGDALQSAAQMPYAALLRARTLKPLAMWETNYTPTPAQCARLLQGVHDEGQCTDTQATAGSSGLYSTPTDISHWLQYLLGQQVGITPGQNPAAQAVYLQPSQLASISGLDHAGEATGIGLGWIHTPGSLDPTATDSEIIEKTGGGAGFLTYIAINQSRHTAIFVAATDGLPETHLNLFKAANNVLLTLAGLPPLPEAPPIYHPASKPKRAAHKAATHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4V2</accession>
    <name>E8X4V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581902.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3588"/>
    <dbReference type="EnsemblBacteria" id="ADW70591">
        <property type="protein sequence ID" value="ADW70591"/>
        <property type="gene ID" value="AciX9_3588"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3588"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076542_0_0_0"/>
    <dbReference type="OMA" id="GTGRSIC"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="86"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="239" mass="26033" checksum="3D511F9F68DF142A" modified="2011-04-05" version="1">MKDREYYGIDAPGVVRTLGIVGALFLICGVLPKSVPGAAVIHNFWLSGVSLLAACGWMLASSLWLKKRVMRALLDQRRWLGDEVVLDVGCGRGLVAVEAARRVPRGRVHGVDIWQEADLSSNSPEAIRVNATVAGVAERLVIDTGDARKLPYADASFDVVASMTAIHNIPDGEGRRKAIAEMWRVLRPGGQILIFDIRHARTYLGQLREMGASETVLKGPIVLWGPLGWRFCATKPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X553</accession>
    <name>E8X553_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase II</fullName>
            <ecNumber evidence="7">3.4.17.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1255</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.21" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579640.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1255"/>
    <dbReference type="EnsemblBacteria" id="ADW68317">
        <property type="protein sequence ID" value="ADW68317"/>
        <property type="gene ID" value="AciX9_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1255"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_2_1_0"/>
    <dbReference type="OMA" id="VFAPGIW"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="PTHR10404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="SSF47672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234387" evidence="3">
        <location>
            <begin position="21"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="6">
        <location>
            <begin position="348"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="TFR_dimer" evidence="5">
        <location>
            <begin position="641"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="730" mass="77980" checksum="BAA8C03B77E1DE8E" modified="2011-04-05" version="1">MNRPAILPVLLALSSAAALAQSATQSSVPPAPTSVFGYKDFSQQAKWDAAFQAIPDSKLAGEHLKTLTKAPHWASSPEDYATAEYVAAKFKAAGLQTEIVPYKVLLNKPVKIVIEAFDATGAKLMSGPSPEHVDPTKDGGDPFQDDPRILPAFNGSSPSADIAAEVVYANYGTPADFKKLADLGVDVKGKIVIVRYGANYRGIKVYDAQKAGAAGVLIFSDPEDDGYFRGDKYPKGPYRPDSAVQRGAVQFLPIYPGDATTPGIASTPNLPDSQRIPADKIQANWPSIPSNPLSYKDAAPILEALGGPAAPHAWQGALPFAYHVGGGPKIMVHMHLEQDTKLRTIWDVIGTIPGTDPAEKNDWVVAGNHRDAWVYGAVDPNSGTAAMLETVHGLGDLLKQGWKPKRTIVIGSWDAEEEGLIGSTEWVEAHPTQLRNAVAYFNTDVGVSGPNFNASAVPSLKQFVREVTREVPSPAGGTVYDQWLKGQTDRRNESEDEGGATRGARPAGRNGGTAGEIRIGDLGSGSDYTPFLQHQGVPATDIGSGGPYGVYHSVFDNYNWFIKNADPTFVYEQQQARVFGLEILHMADADVLPYDYQAYGTQLKGYIEAAKSRSSAMGLDFAALESAANRFAAAGVVIRQRQLTPSNTATLNTALRSAEDALLDPAGLPHRAWYKHTIYAPGEFTGYAAVVIPGVNEGIDAIDKARTQTQIESLTAAVNRSAAILEAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D1</accession>
    <name>E8X5D1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580794.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2443"/>
    <dbReference type="EnsemblBacteria" id="ADW69478">
        <property type="protein sequence ID" value="ADW69478"/>
        <property type="gene ID" value="AciX9_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2443"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569575_0_0_0"/>
    <dbReference type="OMA" id="EIRFDHS"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234401" evidence="1">
        <location>
            <begin position="29"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="53869" checksum="A8273E2ED34A9E71" modified="2011-04-05" version="1">MKVRSMKCTKAFLFGACLVSIFTAASFAQQEQPAVPVTQPAVVFEGNFFQRLGQVYIQDWKGNAAPTDVPARRALPAPLDSSPFPSSDWGYGGSTLLGTPDANVYPLMTALKLQNSRTKVYGWVAPSVNFSTSGTNSFPLSYDVVPNRLELNQAVIYIERLPNTVQNKHFDFGYHITGFFGTDYRFTTAKDYLSQQLLQKNRRYGFDPVLEYAELYFPVKDGLNIRIGRFLSVPGIEAQLAPNNYNMTHSLLYTIDPFTDTGIIGTLKLNKQWLVQLGLSAGHDVAPWSDDRKASGIACLNYSTRTNNDNFYACANGINDGKYAYNNLQHYDATWYHKFNSKWHGATEAYYMYERQVPNVAGNVTVPIATETGANGAFCAAGQRTCTAPEYAIVNYINREINPRLMMGFRSDLLNDKKGQRTGIAGKYTENTLYATKYIGSTIMIRPEIRFDHSWDRKGYNLGQARNQFFMGLDLIYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G2</accession>
    <name>E8X5G2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Excinuclease ABC, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">AciX9_2476</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580825.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2476"/>
    <dbReference type="EnsemblBacteria" id="ADW69509">
        <property type="protein sequence ID" value="ADW69509"/>
        <property type="gene ID" value="AciX9_2476"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2476"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_0"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="431"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="694"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="736"/>
            <end position="743"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADW69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120566" checksum="C90F1BE67BF5E515" modified="2011-04-05" version="1">MSLTPVSPEIAPKPARTFKGITHITVRGARQHNLKNVSVSIPRNTLTVVTGLSGSGKSSLAFDTIYAEGQRRYVETLSAYARQFLDQMERPDVDAIDGLSPAISIEQKTTSRSPRSTVGTITEIYDYLRLLYASVGQPHCPNCARPISRQSAEQIVERIAALNPGERITVMAPIVRGRKGEFREELEALDQQGFRARIDGEMTELTEGMRLEKRKNHTIEAIVDRIILKPLPATPPGAPGPDSGTWVSTDAPNVNATLAGVPPTPKYDTKRLEASVQKALSMANGLVLIGLQDPHTRQVEETLYSSSMACPDCGINVPRLEPRSFSFNSNYGACPECHGLGSIYDFDPAKTITDWSKPLLDGAMGPGSGSQYLLRLIKLAADKYKINLKQPFQALTEPHRNLLLYGPPVGESSRTGFHGIFAYLRSNLEETKSEGYREYMMQYMSATVCPRCKGRRLRPESLAVTVPMTLGTTPGAQQSKSDTNLGAPRPDSGTWDGVAPTSNGAHPVSIADFTALSLERALTAARTMHFSGRERIIADRLQREIIERLEFLNAVGLGYLSLERSAATLSGGEGQRIRLATQIGSRLRGVLYVLDEPSIGLHQRDNQRLIAALEALRDLGNTVLVVEHDEDTMRKADYLLDIGPAAGKNGGHIMASGTPQEVMDNPASITGQYLAGKIPIVTRPARIITAEDGTTTEDMSPRPLTGRWITVEDARSHNLRNVTAHFPIGVMTVVTGVSGSGKSSLVNDILYRALAKELYGSREEPGQHGKVIGIDQLDKVIQIDQSPIGRTPRSNPATYTGVFTAIRDLFAMLPESRERGYKPGRFSFNVQGGRCEACQGEGQRRIEMNFLPDVYVLCEVCNGRRYNQETLAVKFNGYSIADLLELSIADAVPILKDIPNVAIKLQTLVDVGLGYIHLGQSATTLSGGEAQRMKLARELSKRQTGRTLYLLDEPTTGLHFDDVRRLLDVLHRLTDLGNTVIIIEHNLDIIRNADYLLDLGPEGGEFGGTIVGHGTPEQLATVQASHTAHFLRQHLPANTKLNPNPNAGPQPESIRAEADRLKDPKKKFIAPEKKMGVPTASKTKPAEKKEKPAKKAAKKKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W9</accession>
    <name>E8X5W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4068</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70853">
        <property type="protein sequence ID" value="ADW70853"/>
        <property type="gene ID" value="AciX9_4068"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4068"/>
    <dbReference type="HOGENOM" id="CLU_1793774_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="16019" checksum="9691CBC07BFB21C7" modified="2011-04-05" version="1">MARGKKHKAEPIVKLLRQVEVGVANGKSLPQACKEAEIVEQTYCRWRREYGGLKVDQARRLKDLEQENAKLKRLVANLSLEKLVLKDRGGKLLSPERRRCAVSHAREAHGAERAACVPCGEAATGHATLSRHSEMTKTGSPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X608</accession>
    <name>E8X608_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4112</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70892">
        <property type="protein sequence ID" value="ADW70892"/>
        <property type="gene ID" value="AciX9_4112"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4112"/>
    <dbReference type="HOGENOM" id="CLU_016890_0_0_0"/>
    <dbReference type="OMA" id="AFSEMDV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="239" mass="26086" checksum="52D6FBB2DE0A8CE2" modified="2011-04-05" version="1">MGEAGPSHDRWLISYADLVTLLFAVFVVLFAYSWHSKQAIRTVSTAIRSGFDSMSAAQTETAPETPVPDQLRGPTQSADPLRFDTAKLSQQLQGVLGDAIDKHEIVMQQTADGFIISLRELGFFNSGEATLLPGAAAKLQDTAKVLMEDGLEVRVEGHSDDQPIHNGQFQSNWELSTARAMSVLSLLVDEAGFPPTKISVAGYGPYHPVADNATLDGRRSNRRVDLVVLSPRSREEKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X622</accession>
    <name>E8X622_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4126</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572818.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70906">
        <property type="protein sequence ID" value="ADW70906"/>
        <property type="gene ID" value="AciX9_4126"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4126"/>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_0"/>
    <dbReference type="OMA" id="TRDGTFH"/>
    <dbReference type="OrthoDB" id="1488472at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="5">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="6">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="27199" checksum="DE75C32F6D356A7B" modified="2011-04-05" version="1">MIRALYTAASGMTAQQLNLDNIANNLANSSTTGFQQRRLAFSDMLYQNTTSPGSAATQQTTNAAGLQVGLGVRPTSTETIQTQGDFNSTGNPLDLAISGGGFFQVLLPNGQTGYSRSGSFHMDSTGNVVTADGNPLQPAITIPPDATNITIGSDGTVSVVQPGTTQSAQIGSIQMALFVNPGGLNSVGNNIYLATTASGDPIIGTPGGSEGLGTIQQGTLEASNVSVVDEFVEMIVAQRSYESNSRVVKAADEMMQQLNQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X638</accession>
    <name>E8X638_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572834.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70922">
        <property type="protein sequence ID" value="ADW70922"/>
        <property type="gene ID" value="AciX9_4142"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4142"/>
    <dbReference type="HOGENOM" id="CLU_524547_0_0_0"/>
    <dbReference type="OrthoDB" id="2184325at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="51937" checksum="348CB95983181093" modified="2011-04-05" version="1">MHISSQIASSISTGNLKSNPPAALDSIFKHALVAASQTAMPAPTSPVEKKSDHPKNSTDQAAVPAHQFGTLPVPVPVALSQPGISLPDNGSSSEDQSAQSSGPGSSSSPSLQTTAPFSATVHPLQAGVEDGVGQFSDTPVTGKPAQTPDSSSATAQPTQPVKSASEASAKEDAAAPNRLPIALPIPQAPGADLSGLLDPASPDSSQAPATDGTANQPTQPPAPSDPAALLASVAQTTFVVPAVVPTLPALSAGQSTSNAVAALGSAKPAGVAGKTHAPSSDIAARRKVDESDTDASETESAASNSATLIQAEPQVNHSAPDHQSAANDPAAQQALQAALSSSVPAHASIQAVTPTITSGADAAATQTPVTVKPEAVSTPALSSAQLIQSMHGSEMRLGMHSTEFGSISINTSLSRQVLSAQISTDHSELSRALAVHMPAIQEKLGNAYGIQAKVEVHNSSSASSGESARESNSQHNDSRRQGRTGSLTGSPISLLASSTANSSSSASVASSDARLDIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X679</accession>
    <name>E8X679_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_4184</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572875.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70963">
        <property type="protein sequence ID" value="ADW70963"/>
        <property type="gene ID" value="AciX9_4184"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4184"/>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_0"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="435" mass="46022" checksum="3D42FF5B073DE636" modified="2011-04-05" version="1">MRTRLEQYFGFTAHNTTWRTEILAGLTTFITMAYIIFVNPAILSQTGMPIAAVTAATCLCAAFGSILMGAIANYPLALAPGMGLNAYFTYTVVKGMGVPWQTALGAVFLSGIIFLLLTFGGIRQRLVAAIPHQLHAAVGGGIGLFIAFVGLTNSGLIVTSSAHTVALGNLRAPATLLALFGLLLIAVLQVLRVKAFMLLGVFGTMLAGLAFHQLHWQPTPFDLTAIKATAFHLDLRGAAKFGVFEIVFVFLFVDLFDNIGTLVAVTERAGLMAPDHSIPRLSRIFLADATATVVGSLAGTSTVTSYIESSAGVEAGGRTGVTAIVTGLLFLIALFIAPLAGAIPVYATSPALILVGALMLTGLGKIEWSDPQIAIPSFLTLVMIPLTWSIADGLSFGLTSYALIQLLTGKARRQDWMLYLLAALFVFRFAYLAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C2</accession>
    <name>E8X6C2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572918.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71006">
        <property type="protein sequence ID" value="ADW71006"/>
        <property type="gene ID" value="AciX9_4229"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4229"/>
    <dbReference type="HOGENOM" id="CLU_138549_4_1_0"/>
    <dbReference type="OMA" id="PVPNKWG"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="12634" checksum="9A2C4699A07BECDA" modified="2011-04-05" version="1">MTADDFKRIALSLPGAEAAQHMGSPDFRVGGRIFATLAHLNLGYGNLMLDPQHQQDFLAEAPDLFLPVKGAWGLKGATHIRLAAANEAVLTGALQAAWKLRLARNKGTPRPKPSSNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D8</accession>
    <name>E8X6D8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxyproline epimerase</fullName>
            <ecNumber evidence="2">5.1.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4246</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572934.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71022">
        <property type="protein sequence ID" value="ADW71022"/>
        <property type="gene ID" value="AciX9_4246"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4246"/>
    <dbReference type="HOGENOM" id="CLU_036729_1_0_0"/>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="OrthoDB" id="559014at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047580">
        <property type="term" value="F:4-hydroxyproline epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="33959" checksum="C973028D58B116D2" modified="2011-04-05" version="1">MSMNTAVLVVDSHTEGEPTRVVVSGGPDLGQGSLMERVERFRRDFDGFRSGVVCEPRGSEVVVGALLVEPLSEDASAAVLFFNDVGYLGMCGHGTIGVIKTLAYLGRIKPGQHKIETSVGDVSACLHEDGSVTVSNVPSYRLQASVPVDVPGLGRFVGDIAWGGNWFFLIGEHPFEILPSNRAELVAASTAIRNALHASGIKGVPGEHSDYIDHIEFFSEPVDPANSSRSFVLCPGTAFDRSPCGTGTSAKMACLYADGKLVPGQTWRQESILGTVFEGTVEPGEGEMVLPSIRGRAWITGESKLIFAGDDPFSKGIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6K3</accession>
    <name>E8X6K3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3871</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71153">
        <property type="protein sequence ID" value="ADW71153"/>
        <property type="gene ID" value="AciX9_3871"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3871"/>
    <dbReference type="HOGENOM" id="CLU_228925_0_0_0"/>
    <dbReference type="OMA" id="ELHRDMI"/>
    <dbReference type="OrthoDB" id="7641at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1249"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1532"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1672"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1856"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1615"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2008"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1615"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1633"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1655"/>
            <end position="1669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2558" mass="269765" checksum="0F1A08F0ADD1A03B" modified="2011-04-05" version="1">MQNINTVLLSDRASGRPALRAVVVATDHIEREMFAPPQGRTRFMALRLLLASSLLILAPWLLMANAQQVERYLPLSQRSTINLSAGVPQYIGDATNTSSAPQNPWLYENTVNSTQYSAQDFVENTDSAAHWQPVGVPYDANIPRTFINQTSGGGDGSLTGNQNWYRLHFKVDPKYAGQKFLLNLEGSHTAVQVFINGNLLPGMSLVAANAKATHVVGFIPVVVDLTPYIKADGTTDNVIAIDVSRGDPWFEQPGFSGAFRFGQAMAGLFRNVYLYVTNPVHIPVNVYSNQKTWGTYVGTKSIDFSAAATATANSAQVEVQTNVLNETNATQQVTLTTQIVDASGKVVVTAAPLTQSVPAMTAATFPSGPTPIFDQTITVPNPTLWYPNNSIYGKPYMYKVYHIVSVNGVVVDSAQSPLGIRMLTWDKNFPYFNGHQQYLWGASGRYDYPGLGSAVPDEQVWRDLAQFAAGGGNVWRPGHSTSSEEFVEAADAYGIMIDQPSGDGEGHWSLSSNTPPTADDLQLKQELHRDMIIRDRSHPSILDWEEDNGGNNTLLASQLDTLEQQWDSIQIRKQATRSGDTSYAYINECDQAGCEIASKQNNEDFPAFGAEYWDNVGTGRGLAYDNELSFAAPYLDDWRRGRAVNTFGMAQWYFAETPGEISLWSEYQNNPAMVNFVRSLGYSEVDQNRFPRLLYYIYEANWVPYSIKPVVALAHHWNRAYEYTQGTPIQVNAFSNCPAVRLLINGVAKDPVTGAILADQKPNDWTSNSSLDLTQNTTVMPGQVHWMVNFAPGNVTAQCIDETGNPGISDTRVTAGPEYKIVLTAVPELQKPDGSSFQWTSNGSDAAFVVAQVVDQQGNIVPTAADNVTFSVRGPAQYMGGTQQLVADPSWTNYYQDAFSLANAGIIGGQPNAFFHAPGDPELNFEGGLQKIALRSTFTPGTVTVTATAPGLVGNSVTLTSVAPPPPTTTQAPAIIVPPVSTAVTQGQPATFTVSASGSGTLSYQWFLNNNAVAGANGTTFITGATALSDNNDSIMVTVTSASGFGSVSSNPAILSVSPPQNVAITTSPASQTSVVGQTATFNVVASGSPQLNYAWFKNNNQVASGPLSSYTTPILTMADTDTYYVIVSNPLNQVQSSNAVLTIAAPLPVSITGSPVSQIVASNQPVMLSATVVGSAPFTYQWNFTPQGGATTILESNLQSSSVFNFTIPAMSASTAGSYTITVNNAANAPATSASAQLTLAPPGVNLAYAMPATASSSQQNCNDLTTAPPLSGANCLGAENAVDGNLATRWASASAGAPPTTLTPGVDPSDLIIDLGATQPFNTVAINWENAYATDYEVDYTNDDPTANPQWVQAIAKHDGGGSSETLSFGTVRGRYVRMHANQRATQYGYSILEFQVYNLAQCGGVNERYTPSTADTSLVVDNLLNLTWTRTVQTDATTGAQFTGDKAATFCANRSMRLPTKAEALSISGNNYASCAFNGTWSTWTSTVNPTDSTETAIVSFNGDVTQNVTLNFPGATLCTTGTFAGQAPLITAAPQPSTVTLGLSATFKVAATGVPSPTYQWSENGTVISGATEPTYITPPTTTNDNGATFSVAVTNGSGTVVSTPVALTVSSTPLPPPTGPTGPTGPTAPNNPGAITAPTGSPTNPANPVIPTDPANSGNGNTNSTDTMITGFGTTLAPLGPNLALGGAALSTGDENPGLGPINAVDGVATTRWSSAFTNASDMQVDLGSVQSVGQVVLRWERSFGFQYQIRVSTDGQNWTPVFTQMQGQGGTENLVFPAVNARYVQFYGIQRSSQYGYSLWEMEVYAPAPTAPLATPDPLITAPTGSATNPMQPVIPTDPANSGNGNTNGTDTMITGFGTTPMPTGPNLALGKPTLSTGDENGGVGPANAVDGIATSRWSSAFTNASDMQVDLGAVMPVNQVVLRWERAYGFQYQIRTSTDGQNWTPVFTQTQGQGGTENLIFPVVNARYVQFYGIQRSSQYGYSLYEMEVYGSGTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGAIAFTAQPANQNATVGSAATFSVTAAGSGPFTYQWLKGGTPIAGATFATYVTPTLTLTDNASTFSVLVGSTSGATPTTSSAATLSVTPYTVVKGAIDIDLVNNTHGAWSNDQVYITMIGFDPSNGNRAYVNAAGQIVDFTTADSSAANHLTGPDGLPYGNYSFTLAQASNLKLSPLGSARAFVSLGVPLYIGLPPPDNTGKITGFVGPVHDNPTDPNYNTHFDWYEFDYHANPDSSTGIFINTTQVDEFGIPLVLDVFASNASFHQQVGITETVAQIDAEFAAEVPIQFQPSTLTNLFIFSPAKTGMPMFADTLNPQNNGPFANYFDNVVQTAWTSYATKPITINLAGRQYSGTAAGKTLTFTEVNAAQQNVGEIFTVQQPTTQEVLICAGSMNSGVDITGAPGSPLAAMQQDEDGVQRQLQNQICSATNRGILLKSPTTWADASTYFPAAPDNAYAQFWHKHSIGGFAYGFSYDDNNNQSTTISTGNPEHMTWTIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N1</accession>
    <name>E8X6N1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3905</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582199.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71181">
        <property type="protein sequence ID" value="ADW71181"/>
        <property type="gene ID" value="AciX9_3905"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3905"/>
    <dbReference type="HOGENOM" id="CLU_146749_0_1_0"/>
    <dbReference type="OMA" id="MRIMEDA"/>
    <dbReference type="OrthoDB" id="1984529at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="117" mass="12744" checksum="AA99350346977C73" modified="2011-04-05" version="1">MLKPGPALKVSVHLNEDIDSPGGFLHDAVLSLLQDHFIAGATVYRPYAGFGSHGRLHVYGAGSVRGEHLPVLILFVDEEERVRALLPQLLELVTDGMVEMHYTEVLKAAATPAKVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6P3</accession>
    <name>E8X6P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3917</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71193">
        <property type="protein sequence ID" value="ADW71193"/>
        <property type="gene ID" value="AciX9_3917"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3917"/>
    <dbReference type="HOGENOM" id="CLU_1967452_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="13889" checksum="D41ED8E39459F9A2" modified="2011-04-05" version="1">MPKHPLLSRRDPSFPRYTLFLPAPSPTAHQGIAAFSQRVNVPVGPSGPSSTTRTTSRDPSSTDSVPAYPLRFVFVNVLWLRRLMDFFGPKCGLGAALYSGDPRLRSCHGGSPGRPTVLRSKKQTTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6S4</accession>
    <name>E8X6S4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit</fullName>
            <ecNumber evidence="4">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3948</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="4"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582242.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71224">
        <property type="protein sequence ID" value="ADW71224"/>
        <property type="gene ID" value="AciX9_3948"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3948"/>
    <dbReference type="HOGENOM" id="CLU_031955_0_0_0"/>
    <dbReference type="OMA" id="MPVTQWS"/>
    <dbReference type="OrthoDB" id="1706318at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="43347" checksum="6654733C3251601D" modified="2011-04-05" version="1">MKTPWLKIVGIGEDGWEALTPAARSAIAQAAILYGGTRHLAHIPPEATAATRTPWPSPMAEAIEKILTQHRNQQQIAVLASGDPMLYGVGVTLTRSLSPDEFVVIPGVSAFALACARLGWPAAEITLISLVARPLEQLHRALAPNQRLILYSEDGTTPAKAAAFFTAAGYGPSLFHVFENLGGPTEHRTSAPASAFPTEPFGNLNLIAVQCEPAPDTQLLSLVPGLPNEAFQTDGQLTKREVRAATLARLAPLPGQHLWDVGAGTGTIAVEWLRTHPTNTAIAFEEKHTRAANIRANAAHLGTPSLQTIEGQAPATFATQTQSPDAIFIGGGLTIPGLFEACWHHLRPGGRLVANAVTLESEALLITLQARHGGDLTRLQIAHAEPLGPTQIWRQGMPITQWTATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T9</accession>
    <name>E8X6T9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3963</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582257.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71239">
        <property type="protein sequence ID" value="ADW71239"/>
        <property type="gene ID" value="AciX9_3963"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3963"/>
    <dbReference type="HOGENOM" id="CLU_2034787_0_0_0"/>
    <dbReference type="OrthoDB" id="2184222at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13370" checksum="FC20917E44EFFD3B" modified="2011-04-05" version="1">MNKFGLLDEEDDAQPTQQTAQASLTDRLAAFPAVTPRPRVDLAAVDAAGAAHGFVSREASPYQPLQQGRRRRAIPSEPTRHLAIRLTASAYDRFVAYADLHKLTYHDALTRLMDESGVNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U6</accession>
    <name>E8X6U6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3972</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71246">
        <property type="protein sequence ID" value="ADW71246"/>
        <property type="gene ID" value="AciX9_3972"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3972"/>
    <dbReference type="HOGENOM" id="CLU_046640_1_1_0"/>
    <dbReference type="OMA" id="LTHQDVG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="186"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="355" mass="40541" checksum="530D4913FB5FB446" modified="2011-04-05" version="1">MSGDEREVMGRGGLRVDGDVSHLLAGLRELIQEARQRVLRSVDEVQVQTYWEVGRHIVEFEQGGAARAAYGSKLLQTLAGELAAEFGKGFDVSNLRHMRVFYQAFPKQDALRRELSWTHYRTLLRVESGAARQWYMQEAAGQGWTTRALERQIGTLYYERLLSSSDRAEVEREAGEQVSKLATPRDFVRDPVMLEFLGLPGTGKLLEADLERALLDNLQAFLLELGRGFAFVARQFRVSSESKDFYIDLVFYNYLLKCFVLFDLKSGELTHQDIGQMDMYVRITDDLKRGPDDNPTVGIILCTQKDASIVRYSVLHENEQIFASRYKLVLPSEEELRAELDRERGKLAEGAGWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y5</accession>
    <name>E8X6Y5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cys/Met metabolism pyridoxal-phosphate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582116.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71094">
        <property type="protein sequence ID" value="ADW71094"/>
        <property type="gene ID" value="AciX9_3808"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3808"/>
    <dbReference type="HOGENOM" id="CLU_040896_1_1_0"/>
    <dbReference type="OMA" id="PIINCRG"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="532" mass="57099" checksum="1D2F94996927F9CA" modified="2011-04-05" version="1">MSLLRTTRWSRREVLKQSGMISAVGAATSISPALAQSSPKAPTITHHGTSTDNLFTQIGVRPIVNGHGTFTIISGSRSLPEVKQAMYDASFYFVHLDELQDAVGKELGQLTGAEWGCATTGCEAAIALATVACIAGTDVEKSQALPYIKAKDQVIIPKHSRNPYDFGVRMTGAEVVEVDSPEELRAKISKRTAMIYILSGPAAEKGPMSIPSICAIAKEMGVPVFVDAAAEEPLNPNIHIQHGATLVGYSGGKCMRGPQSSGMLIGQKDLVRAAYFQAAPHHNYGRAYKCSKEEIMGLLAAVRQWYKRDHAAEQAEWVSWLQHIESRVKGLPSVTTEYLHPDDLSNNSQRLRINWDATQLKITGTEMIERLDAGTPRIMVDGGSGSRPDHMASSLTIMPYMMAAGEDKIIADAVYALLTNPGPYANPVVPSGAPAKVAGTWAVSIQYSRGEGEQHFTLTQSGNDLTGTQKGELYTTPLKGSIHGDQIALNSDMKVSGHSVGFNFKGIVQGSTISGTVNLGEYGTATWKAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X763</accession>
    <name>E8X763_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4345</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71297">
        <property type="protein sequence ID" value="ADW71297"/>
        <property type="gene ID" value="AciX9_4345"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4345"/>
    <dbReference type="HOGENOM" id="CLU_2368927_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="95" mass="10412" checksum="3E078E929CF70C8D" modified="2011-04-05" version="1">MYSGDLSLRLRAANATTAEDSVNHAAFIVREMVNPLESVNNQAYLLYLSAQEPDQVVQLIAMLQSQLTILNEIVQSALNAAKNEPDPESAKTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X799</accession>
    <name>E8X799_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4382</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71333">
        <property type="protein sequence ID" value="ADW71333"/>
        <property type="gene ID" value="AciX9_4382"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4382"/>
    <dbReference type="HOGENOM" id="CLU_070500_1_0_0"/>
    <dbReference type="OMA" id="CRSEVVQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043749">
        <property type="entry name" value="DUF5694"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18950">
        <property type="entry name" value="DUF5694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="273" mass="31309" checksum="FF874C548F49B206" modified="2011-04-05" version="1">MQYMSLSRFFSIFWMTLLAIPAFGQEKPQIMILGTTHFNNPNHDISNMVIDDVLTPERQQQIRLLVGAIARFKPTRIAIELPPSEQSALDQRYADYRAGRYSLTSNERDQLGLRLAAMLQLPRLDAVDYKEGPPGPDEAYDFSAYAAAHGQQKQFDGFLAAGKQYAADETTYLHTHTMLEWFRHANTPQYRLLNNKFYFDMLRFGDNKINPGANWVGGWHARNLIILENVWRLSKPNDRILVIFGAGHTFLLNQFSSDSGEFNVIDTERYLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H7</accession>
    <name>E8X7H7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4465</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573130.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71411">
        <property type="protein sequence ID" value="ADW71411"/>
        <property type="gene ID" value="AciX9_4465"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4465"/>
    <dbReference type="HOGENOM" id="CLU_1576289_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="18353" checksum="5DDD60B9360B3253" modified="2011-04-05" version="1">MQIFGRQVSNWWWFLVVPLLLVCIPFFLFLLIIAGHIGGAVFGPPALWAIPLHTPSRVDLVGSYFETNQGAAIQADTLNASLDLNLDGTMTVRALPEDSVTSTCVMSGTGRWKVLDGNIDLDYNSDGASGSCASGGYSLLEVAGHSKPYKLYWVLGDPDSGTGIWFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V2</accession>
    <name>E8X7V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4606</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71536">
        <property type="protein sequence ID" value="ADW71536"/>
        <property type="gene ID" value="AciX9_4606"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4606"/>
    <dbReference type="HOGENOM" id="CLU_1136793_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234491" evidence="1">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="244" mass="26246" checksum="8F45F8EEB30052B8" modified="2011-04-05" version="1">MFFSLLQRSIRLSAFFLLAVTVGEAQSKEAPLPPDVPAVECKPPAVVNFDGLRVFSGTAPVLMTFHCGDKGSEAAACHAEYLDPAKPDEYQGDLIAPGATQGRWTCAMVGGWSGWIPTDRLAPVPSTPAITTEQWLGTWVTGHAGVHNDRLVVTRSAEGHGKIHVEGRANYTNIAHNVHTGQVSGDAVAMGPFLHILDHGELPDCVLDLKYDLASKTFRAVDNQLCGGFNVTFDGTWHQAKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Y0</accession>
    <name>E8X7Y0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV secretion/conjugal transfer ATPase, VirB4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4634</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbE/VirB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573283.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71564">
        <property type="protein sequence ID" value="ADW71564"/>
        <property type="gene ID" value="AciX9_4634"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4634"/>
    <dbReference type="HOGENOM" id="CLU_355547_0_0_0"/>
    <dbReference type="OrthoDB" id="182908at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018145">
        <property type="entry name" value="CagE_TrbE_VirB_cntrl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03135">
        <property type="entry name" value="CagE_TrbE_VirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CagE_TrbE_VirB" evidence="2">
        <location>
            <begin position="297"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="446"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="3">
        <location>
            <begin position="637"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="789" mass="88695" checksum="C69A6C33A36A438E" modified="2011-04-05" version="1">MILAKATNDPKLTPWYTKAGAACSIVPISRFLTPTIFALKGGGYGCVFSLRGADEESLTDQELESRVRMIQGALRGMPEHSCLYEYCRVLNGYDLPRQSQYASAVTAKFVSDRLNFLDQRAGFRRIDLYWCLTVEPPKTAALKKKPHENAGENARMLRNLEKAATILEEHLRTVLGIRLLLKAEAFAFFSYLYNLEPWADFDRLGSDTGVDRQIVKSPVSWHNDHLQVGKRYVQMFSLMNTPDTSRPCQFSGLMTLDCDSVLCTSWRPKSGAAARKEIENQEKFISFFKVGILTRVMSGKDTASLETGAGAKAAQTNVDELSEVIHSLDRTAQGEYTMRLLLAARSKAELHDAIPAVHRVFVEARCQVMEETLGNLSSFYTMFPGNQRFNVFPLWLGEDHHARMSLAFAPHIGHPVSEDLDSEYLNVFETRTRTPFFQDVYVNGVRVMLILGPTGSGKSIHGNNLIAFEQKYGGFTYIFDIGNSYESVVELYGGRIDKVGKDGPRVNPFALEPNEDNLQFLHSFVKLLLTNGGAVLTPEDEDTVFGAVKGVYHLDRHLRRLSAILLPKHLQRYLSKWIGSGLYNAVFDNVEDSLSLGRLQCFDFQGITGQHADLVEPLMVWLLRRINEVLYDPKNLGVPKHIMIEELFSAMKNSQLLDAALASIKTVRKNLGGVTLIGQSANDLGANADSIVNSCTSFLFLPDATFNRKFYGELFKLTTQQLDLFESLREREALYVRRDGLTKVVTLNLDNRSYAKFSTRPKDRVRRSKLVEKYGLTEGIERFANGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X828</accession>
    <name>E8X828_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4683</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71612">
        <property type="protein sequence ID" value="ADW71612"/>
        <property type="gene ID" value="AciX9_4683"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4683"/>
    <dbReference type="HOGENOM" id="CLU_2069798_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="118" mass="13305" checksum="F17D44DBB94AAFAC" modified="2011-04-05" version="1">MAGANLQYNSAMPTHLDAIYLNKHEDRPESVETVMLEGQPMEVLINDWTYYRVRGGEHTGESSVQICRVTFPKFEDDGTVIDLPFRVGKTGVPEELDTITQEQWGLLHSQSIHIGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV80</accession>
    <name>E8WV80_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bilirubin oxidase</fullName>
            <ecNumber evidence="3">1.3.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0181</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0181"/>
    <dbReference type="EnsemblBacteria" id="ADW67255">
        <property type="protein sequence ID" value="ADW67255"/>
        <property type="gene ID" value="AciX9_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0181"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_4_0_0"/>
    <dbReference type="OMA" id="LLPKQWG"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047705">
        <property type="term" value="F:bilirubin oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="367"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="504" mass="57214" checksum="34F0A787C7C70EA7" modified="2011-04-05" version="1">MNMGQTMHKTPAAPDHTVPMLHSLELMPFVDAMPVPPSLLKATASHASLRIAMREIHAKVHRDVPATRMWSYGPEALGPVIEARSGHPMSVQWVNNLPVKHFLPIDHSLHGCGRDIPDVRTCVHVHGARVPTKDDGHPEDWFTPGNSRTSHYPLEQESATLWFHDHAMGINRLNHYAGLFGMFWLRDEQEDALHLPNGKYELPLVLYDRDFTTDGQLFYPTSGDPEHPWVSEFTADAILVNGKIRPYLEVEPRLYRFRTVVAANSRFFGLTLSTGASLVQIGSDQGLLSAAVEVPRLNIAPGERADLLIDFSKHAGEKIHLRTGALDILEFRVAARTGAPVASLPNNIRSIPRTPETAATVTRTITLNEYQDKAQNSMLMLLNRKHWHEPVTERPRLNSTEIWEFVNQTEDTHPMHLHLVRFQILDRRPFDTFQYLMQKEMRFQGPAEAPAPNEQGWKDIVHCPPGMVTRIIVKFEGYTGDYLYHCHILEHEANDMMRPFEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV91</accession>
    <name>E8WV91_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0192</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578594.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0192"/>
    <dbReference type="EnsemblBacteria" id="ADW67266">
        <property type="protein sequence ID" value="ADW67266"/>
        <property type="gene ID" value="AciX9_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0192"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_0"/>
    <dbReference type="OMA" id="WFIEIDE"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="39188" checksum="DE0FD007C34E3E5F" modified="2011-04-05" version="1">MSDSSRTLVINSSTGSYQVTIESHSLRKNLLHFSKAKILADEFFAPVLADLASPPLLIRAIEENKSLDVSPSIIEGLRQSGANRQTELVAIGGGIIQDLSAFIASIYMRGLTWSYLPTTILAMVDSCIGGKSSINVGPYKNLVGTFHPPHQVLIDPALAQTLPPDQQASGLIEAAKICFCRGPEAFDRHIALLPSVMMETGALEALIYNSLEAKKWFIEIDEFDNKERLLLNFGHTFGHAIEGATHFAIPHGIAVGLGILCAITYQVADGIDYSSSPRVALLELHLAEMIANSPGTPRALASMSADEMFQRFASDKKHGTEDYALILIDQAGKVVLHRVPKSPEVSNKVRAAVESVVGRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD6</accession>
    <name>E8WVD6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1322</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579707.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1322"/>
    <dbReference type="EnsemblBacteria" id="ADW68384">
        <property type="protein sequence ID" value="ADW68384"/>
        <property type="gene ID" value="AciX9_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1322"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_0"/>
    <dbReference type="OMA" id="YATSKQC"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="307" mass="32845" checksum="055176709DA04D2E" modified="2011-04-05" version="1">MPKIKSNTESKAYVLTGPTSGSGRATALNMVKLGILVLVGRNAAKLAKTKKEIEHLGGRAVSVVCDFSDLASVHRAGADIVSLNLSIVGLLNNAGIQNPDVTKTGDGWDNTFVTNHLGPFLLTEVLLPHLEDGANVLFVGSATEDPERKLAVRAGFRGGRYLSAEESLHGKWGPGGSTKPGMDAYATSKQCNIVTAMAFARENPRLRINAVEPGIMLATGLHDHMNVPRKILTSVLVLLLVPFVKVLSTPKRAARVFTRILTDSSGPSGVYYDEGGHPMQGSTLVRDRTFQDRVVAETRALLTKLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR1</accession>
    <name>E8WVR1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 region 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2563</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2563"/>
    <dbReference type="EnsemblBacteria" id="ADW69590">
        <property type="protein sequence ID" value="ADW69590"/>
        <property type="gene ID" value="AciX9_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2563"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167401_0_0_0"/>
    <dbReference type="OMA" id="WREPSSF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="110" mass="12077" checksum="2436AADEE8247359" modified="2011-04-05" version="1">MSTAGVFAQSDAILFARVQAGDEKVMGLLYDLYSSVVYSIALAVVSSTDNAEDVLHETFMQLWREPTSFALRDGSLKASLATSTFRRAVQVRDKYQAAAFTASKNKEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVR6</accession>
    <name>E8WVR6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix-domain containing protein AraC type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2568</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580910.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2568"/>
    <dbReference type="EnsemblBacteria" id="ADW69595">
        <property type="protein sequence ID" value="ADW69595"/>
        <property type="gene ID" value="AciX9_2568"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2568"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_0_0"/>
    <dbReference type="OMA" id="AYVACYW"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="30153" checksum="5078828EE631E596" modified="2011-04-05" version="1">MLTTQSATPDAVLQPFVQCYVQRVSKSGEVIEPVFPRAGTMLIFQFADIYEVKEYATEQLRRSWAATVVGPIAARRTRLILRDHVDSLDVLFRPLGMYRLFGVPISPLTGGGAEGRAVFGPQISSLYQRLGNAESFAERVQLLDRFFLRRLQQAHPLDPTARAMRWLASGRCNVGDAARMVGISERQFERRSKQWAGVSPKALARVSRFQRAIAEYRSGHSTWLDIAHKVGYYDQMHLIRDFHDLGGGAPTQVVNEILDEHLISFCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWI0</accession>
    <name>E8WWI0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(II)yrinic acid a,c-diamide reductase</fullName>
            <ecNumber evidence="2">1.16.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.16.8.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580959.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2619"/>
    <dbReference type="EnsemblBacteria" id="ADW69644">
        <property type="protein sequence ID" value="ADW69644"/>
        <property type="gene ID" value="AciX9_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2619"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_3_1_0"/>
    <dbReference type="OMA" id="FMQPWDF"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043784">
        <property type="term" value="F:cob(II)yrinic acid a,c-diamide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="217" mass="23631" checksum="91465CCB36969AEE" modified="2011-04-05" version="1">MDFSADERGAVYRAIAERRDVRRGFLPEAVPDEVMMRVLGAAHAAPSVGLMQPSRFVVVRDVAVRTAVREAFLAANASAKEAYEGERRELYDGLKLEGILEAPQNVCVLCDACSDQGHGLGRQTMPEAAIYSTVCAVQNLWLAGRVEGIGVGWVSILDMAKLREILGVPERLTVVAYLCVGYVGEFGRGPELERVGWESRRGLEGAVSFDRCGAEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK9</accession>
    <name>E8WWK9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative cysteine ligase BshC</fullName>
            <ecNumber evidence="1">6.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bshC</name>
        <name evidence="2" type="ordered locus">AciX9_2648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BshC family.</text>
    </comment>
    <dbReference type="EC" id="6.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580988.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2648"/>
    <dbReference type="EnsemblBacteria" id="ADW69673">
        <property type="protein sequence ID" value="ADW69673"/>
        <property type="gene ID" value="AciX9_2648"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2648"/>
    <dbReference type="eggNOG" id="COG4365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022249_1_0_0"/>
    <dbReference type="OMA" id="TTGHQLN"/>
    <dbReference type="OrthoDB" id="295429at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01867">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011199">
        <property type="entry name" value="Bacillithiol_biosynth_BshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10079">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012535">
        <property type="entry name" value="UCP012535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03998">
        <property type="entry name" value="thiol_BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="537" mass="58302" checksum="BA23B1007C42296D" modified="2011-04-05" version="1">MSPECYPMSVLPHISKLYGDYLAMGGDADTPLRGWYGAEPLGAGWMGREVGVAHSSRLADLLKDQVREFGGGAAALANVERLRNGAHAVVTGQQVGLFGGPQLTLLKAATAIARAKEAEKVTGKAHVPVFWLASEDHDLAEVDQVSLPGKKELETLRLGLRGHGGEVGKILLGDGVENALDQASELLGYAPVCDLLREFYRPDATLAGAFARLMTRIFEEYGLVVMDAAGQGFHALGVSALRAAIERADELERALLARTEELERLGYHAQVLVKSGASLLFLVDERTGERLPLRRLADERWKSGARTYSVAELLEILETTPERFSPNALLRPVFQDTILPTAAYIGGPAEIAYFAQSAVLYERILGRLPAVLPRFSGTMIAPAVETVMSQHEVSLKDLFDAKTPEELTQRLGARAMPIEAKRKIAAAGNALDEELGSLTGYLGSLDESLGRSAEVSANKMRYQMNRLRRMAARYEVQKEASLAKHAGVMMLQLFPDGHPQERIIGGVWFLGQWGSGLVDRLVLEAAQMCLGHSVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWP8</accession>
    <name>E8WWP8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0304"/>
    <dbReference type="EnsemblBacteria" id="ADW67376">
        <property type="protein sequence ID" value="ADW67376"/>
        <property type="gene ID" value="AciX9_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0304"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844029_0_0_0"/>
    <dbReference type="OMA" id="NTIVQHF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="329" mass="36577" checksum="CFB476875EE1B203" modified="2011-04-05" version="1">MAPLRFSVGIPTFNQAEYLVETIESLLQQTRPPDEIVISDHYSTDGTAEIIRRYAGKVRGVQPPPGVNLTGQYNFTLTSQTGDWITLLSSDDVARPNFCEVLERGAMRQPDAVLVRTGWENIDAAGKTVSTNYMLSVPKVEQPPATLISQKNGPKVSFAAFALKREAYMKSGPILGSLESLADWGLFLQMAPFGSFVYEHELISGYRVGHDGDKFRRRLGMWIRDEERIFREVIPAAAERCGMADTAWIMEAAGANFQRYLSAASKEFTPQERGEIVPLFQSWAGMVGGKAMLERFRAGETIETPATLLERAKSLLRPLAQGVLGRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWY0</accession>
    <name>E8WWY0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1488</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1488"/>
    <dbReference type="EnsemblBacteria" id="ADW68541">
        <property type="protein sequence ID" value="ADW68541"/>
        <property type="gene ID" value="AciX9_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1488"/>
    <dbReference type="eggNOG" id="COG1437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_0_0_0"/>
    <dbReference type="OMA" id="LECELKY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="208" mass="23299" checksum="B7C862DE18A5E9B5" modified="2011-04-05" version="1">MADASLILQIMQSAEIELKLPVDDLQALHDKLDELGFQVDTPRTFEQNTLYDTPDRSLKAGGQLLRVRQYGDKFVVTHKRHPDDEEPDSFYKVRIETESEVADGPALAEIFTRIGYGPTFRYEKYRTEYSHRDAPGAHLVVDETPIGNYAELEGPTGWIDRTLNALGVDPGVCLTESYGKLFLAWKKRTGSPVENLTFAEIAPVLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX13</accession>
    <name>E8WX13_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="7">DHBP synthase</shortName>
            <ecNumber evidence="7">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribB</name>
        <name evidence="9" type="ordered locus">AciX9_1521</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579893.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1521"/>
    <dbReference type="EnsemblBacteria" id="ADW68574">
        <property type="protein sequence ID" value="ADW68574"/>
        <property type="gene ID" value="AciX9_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1521"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_0"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="8">
        <location>
            <begin position="213"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="7">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="388" mass="42250" checksum="038E8FA32790AC0E" modified="2011-04-05" version="1">MAHDGSLFAGVEEAVAAIRAGQMVVVVDDEDRENEGDLTLAAEFVTPEAINFMARFGRGLICLTLTEERADYMRLGPMTSENTSRFGTAFTESVEAREGVTTGISAADRAHTIKVAIDPSSTAHDLARPGHVFPLRARKGGVLVRAGQTEASVDLARMAGLVSAGVICEIMNEDGTMARVPDLVEFCKEHKMLMVTVADLIRYRLQHERYIHRVAESVMATEYGEFRMIAYENEVDGNESHVALVMGDVTADVPVPVRVHTHSLAEDVFGLVGTDNREVIDGSLRMIGEAGRGALIYLHNGTRGFGVDRTVEPHRIVFQKDQRGRERGDDHTQRTLRQVGLGGQILSDLGIRKIKLLTNTPTHVPALQGFGIEIVEQVPITVGAGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX53</accession>
    <name>E8WX53_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2671</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581010.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2671"/>
    <dbReference type="EnsemblBacteria" id="ADW69695">
        <property type="protein sequence ID" value="ADW69695"/>
        <property type="gene ID" value="AciX9_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2671"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_3_3_0"/>
    <dbReference type="OMA" id="YKAPARY"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008272">
        <property type="entry name" value="HB-CoA_thioesterase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01328">
        <property type="entry name" value="4HBCOA_THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16634" checksum="1ABD04E80DA67046" modified="2011-04-05" version="1">MSEMVLGEARVRVRYAETDQMGVVYHANYLVWFEVGRVELIRQMGLDYKTMEREDGVGIAVVEVTCRYKAPARYDDELIVQTRIAGVRGSVVKFAYRVVRAADGTLLCEGATTHVVVDKEMRKAAMPARYAEAFRAAHVPVETAEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX77</accession>
    <name>E8WX77_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2695"/>
    <dbReference type="EnsemblBacteria" id="ADW69719">
        <property type="protein sequence ID" value="ADW69719"/>
        <property type="gene ID" value="AciX9_2695"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2695"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043146_0_0_0"/>
    <dbReference type="OMA" id="GGVGRMC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233948" evidence="1">
        <location>
            <begin position="20"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="47889" checksum="BAA98DF630579014" modified="2011-04-05" version="1">MVGSWVRFFGGVSVSLAMACVAVVPAAALHPKAKVVSAHPTAHKATASKHAAKAEHGRAVKTTPIITRSGKHGHAAVEKVTVKGRHGKVAVIEREVVATRLVRGRHGRLIRVAATPARPRFVGERFYASSFADSSQYTGDITTGEDPLVRAAAIEALGNMNGTALAIDPATGRILAMVNQKLALSSGAEPCSTIKLTVALAALEEGLIKHDTLVSLGGGYKMDLTYALAKSVNPFFETLGRSLGFERVKHYANQFGLGELAGYNIQGEQLGVYPDQELPAALGGVGRMCSFGESVSMTPLQLGAIVAAIANGGTLYYLQHPTTTEEVSAFQPRIKRTLDIGPLIPEMLPGMQGAVAAPWGTARRLQASFTQFPVMGKTGTCSNNGTRFGWFGSFANTPNGRIVTVFFLEGGRPTFGPKAAELTGLFYRSLYDKNYFAPKVQSMSAEGVVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD1</accession>
    <name>E8WXD1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ordered locus">AciX9_0392</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578792.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0392"/>
    <dbReference type="EnsemblBacteria" id="ADW67464">
        <property type="protein sequence ID" value="ADW67464"/>
        <property type="gene ID" value="AciX9_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0392"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_0"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="124"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="32449" checksum="91D4FA77B92A7B1C" modified="2011-04-05" version="1">MSTPQILDGIAVASEIKSEVALEVAALTARGITPGLAVILVGNVAASEIYVRSKVKTCGELGIYSEMITPPESIATEELLEIVASLNARNEIDGILIQLPLPTHVDTKRLLEAVSPDKDVDGFHPVNVGRLVSGQPGLQPCTPAGVMEVLRRRNLPVSGKNAVVIGRSDIVGKPMAMLLLNASATVTICHSRTANLPEVTRQADILVAAIGRPGFVTPEMVKPGAVLIDVGINRLTDQAEVTRFFPNNEPRQALFAKRGSVVIGDIDPAAFPTSSAYTPVPGGVGALTIAMLMSNTVKAATLRRSGINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXE6</accession>
    <name>E8WXE6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein HslVU, ATPase subunit HslU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0407</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578807.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0407"/>
    <dbReference type="EnsemblBacteria" id="ADW67479">
        <property type="protein sequence ID" value="ADW67479"/>
        <property type="gene ID" value="AciX9_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0407"/>
    <dbReference type="eggNOG" id="COG1220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_0"/>
    <dbReference type="OMA" id="KYGMIKT"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="64"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="392"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="545" mass="60121" checksum="7E1DBB59FFC44C86" modified="2011-04-05" version="1">MAIFLPGAAEDQALALDELTPREIVAELDKYVVGQGAAKRAVAIALRNRMRRQKLPPDLADDIMPKNIIMIGPTGVGKTEIARRLAKLTNSPFLKVEASKFTEVGYVGRDVESIVRDLVEIAIDLVREEKLEDVADKAELHAEDRLLDLLLPPTPAAATAANAAAATEVAGTNVIQLPMQMDTESPEYVAPVADVGPSEDKKHEPTSYERTREKLRQQFREGKLDERVVEIDVRDRNQPSFEFIAAPGQDESDMSLKDVLPGLFGQRTKKRKMKVAEAFDYLVQEEEGRLVDMDQVTKLAVERVEESGIVFLDEIDKIAGREGGHGPDVSREGVQRDILPIVEGTTVNTKYGMVSTDHILFIAAGAFHVSKPSDLIPELQGRFPIRVELQSLTVGDFVRILTEPKSSLVKQSTALLETEGLKLEFTPEALAEMAEFAFKVNESTENIGARRLHTIMERVLDEISFQAPDLMKNAKGESSEEGVVGQVGHSAPLGGEVRPDSPPLPVIERRKEDGTVEKVIVVDPEYVRQQVAGIVKNQDLSRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG6</accession>
    <name>E8WXG6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-specific peptidase</fullName>
            <ecNumber evidence="5">3.4.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0427</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578827.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0427"/>
    <dbReference type="ESTHER" id="acism-e8wxg6">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67499">
        <property type="protein sequence ID" value="ADW67499"/>
        <property type="gene ID" value="AciX9_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0427"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_0_0"/>
    <dbReference type="OMA" id="TWYRVTG"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="302" mass="34489" checksum="9EB551BBE675D81D" modified="2011-04-05" version="1">MSDDLLNPAGIRVAGIKMIPVRGGKYKVWTKRMGSGPLKVLLLHGGPGFTHQYLEAMESFLPEAGIEMYYYDQLGCGNSDKPDDVSLWTRDQYREEVEEVRVGLGLDYFVLYGQSWGGMLSIEYALKYQHHLRGMVISNMTAGIQAYLGRLDYLKGLLSAESRVELERLEAVEDYDSAEYQRIMMEELYPQTICRTKPWPEPVTRAFRDANLAIYNEMQGKSEFVVTGNFKDWESWDRLHEIGVRTLTIGAAHDTMDPADLKKMAELMPKGEHLHCPNGSHLAMWDDQAVYFEGLLKFLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ9</accession>
    <name>E8WXQ9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581069.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2730"/>
    <dbReference type="EnsemblBacteria" id="ADW69754">
        <property type="protein sequence ID" value="ADW69754"/>
        <property type="gene ID" value="AciX9_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2730"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_0_0"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="16189" checksum="A3BEA1D1377D1734" modified="2011-04-05" version="1">MAIGRIMALDVGKARIGIALTDPLGYTAQPLLTLWRKTRNEDARSLLRLIRKHEVTHLVVGNPLHLSGDLSPFAAKVHEFAEYLRERTEIPIQLWDERLSSVAANEILDEAGHARGKDRKFIIDQVAAVLILEGWMQAQYRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXS6</accession>
    <name>E8WXS6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2747</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581086.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2747"/>
    <dbReference type="EnsemblBacteria" id="ADW69771">
        <property type="protein sequence ID" value="ADW69771"/>
        <property type="gene ID" value="AciX9_2747"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2747"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_0"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="35264" checksum="9A7B22F8EE9BE421" modified="2011-04-05" version="1">MKILVTGGAGYIGGTVSRLLLERGHEVTVFDSLCHSRRSAIAEGVTFVEGDLADSALLEKTLNAGKFDGVLHFAALIEAGESMKQPEVYFRNNTAGTLTLLEAMLATGHNKLVFSSTAACYGEPEKTPITEEARLAPTNAYGESKLLSEHMMRWMHHSHGLRYAALRYFNVAGAIPGYGENHEPESHLIPLVLDVALGRRASIKIFGQDYPTPDGTCVRDYVHVQDLADAHLLALAALEDKAPLIYNLGSGTGFTVLEVIESVRRVTGKEIPVELCPRRPGDPAVLVASSEKIQQELGWKPQFAKLDSIIESAWIWHQQLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV8</accession>
    <name>E8WXV8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2780</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581118.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2780"/>
    <dbReference type="EnsemblBacteria" id="ADW69803">
        <property type="protein sequence ID" value="ADW69803"/>
        <property type="gene ID" value="AciX9_2780"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2780"/>
    <dbReference type="eggNOG" id="COG3564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134343_1_0_0"/>
    <dbReference type="OMA" id="GSAPMCF"/>
    <dbReference type="OrthoDB" id="1912908at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008497">
        <property type="entry name" value="DUF779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05610">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009151">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13844" checksum="FCB4DD1778B3DB9E" modified="2011-04-05" version="1">MMAPAQVLTTPAADELIHRLREKHGKLMFHQSGGCCDGSSPMCFALGEFMLGDSDHFLGTIAETPFYMSKSQFEYWKHTQLILDVVPGRGGMFSLENGEGVRFLIRSRVFAEDELLELEMAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY05</accession>
    <name>E8WY05_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp/Fap pilin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0472</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578872.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0472"/>
    <dbReference type="EnsemblBacteria" id="ADW67544">
        <property type="protein sequence ID" value="ADW67544"/>
        <property type="gene ID" value="AciX9_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0472"/>
    <dbReference type="eggNOG" id="COG3847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171854_8_0_0"/>
    <dbReference type="OMA" id="MNRGKDL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007047">
        <property type="entry name" value="Flp_Fap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04964">
        <property type="entry name" value="Flp_Fap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6230" checksum="D4E992BB798D69DE" modified="2011-04-05" version="1">MNRGKDLLSDLLEDESGQDLIEYALVAALIGLGAVVAMNGFSTKVKTAFNSVGSSLTNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY31</accession>
    <name>E8WY31_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0498</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578898.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67570">
        <property type="protein sequence ID" value="ADW67570"/>
        <property type="gene ID" value="AciX9_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0498"/>
    <dbReference type="HOGENOM" id="CLU_1223309_0_0_0"/>
    <dbReference type="OrthoDB" id="1726286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234155" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="83"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="226" mass="24225" checksum="602B79F94AF7B6CB" modified="2011-04-05" version="1">MRLITTALLFASASIACAQTSTPPNPCAANVSSSLPESSGCMPLTYKPADGGPERTIMVPVEYIYPQGHSVPVPPTASRLLEFQAGVFGAYNTADYGTTGNIDAGVYASLMARHFGIQVDAADTVDSRAGVREAYVVAGPRFQMRYKPLTIYAKAQAGVARFSATPAPRLNNKDTSAVEQFGGGVEINATRNLRIRVVDYSYQIWPEFNPRNLSPQIVSAGVAFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY88</accession>
    <name>E8WY88_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1665</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580034.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1665"/>
    <dbReference type="EnsemblBacteria" id="ADW68715">
        <property type="protein sequence ID" value="ADW68715"/>
        <property type="gene ID" value="AciX9_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1665"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_4_0"/>
    <dbReference type="OMA" id="HVLTHEI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="219"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="432" mass="46728" checksum="FAA2B82B1F45909A" modified="2011-04-05" version="1">MLAFAGLWTYTLDPSPVMVGVVVLTLGTVWGLAISVFFNQLVRPLQTLANVVSALREDDYSFRARGALRNDALGDLALEINALAATLQQQRSAALDALTLVERVLSSMQSPVLAFDEAGTLKLLNAAARSAFAITERNPIGRTALELNLESLLDIPDQGLYPPADPSGNINFVQGAVRWSVRRAVFRLHGLPNTLFVLSDVGAVLREEERTAWQRLIRVLSHEINNSLTPIQSIAGSLRHRMMRSDAAAVDPADLLRGLGVIEDRSASLNRFLQAYQRLTRLPAPTLQRADLAQLIVQVVHLETRLKPHVEPGPAVHLLCDPDQIQQALINLLQNAADAALSQDSAARPDASPAVQITWTVHQEQLSIFIEDNGPGITNPGNLFVPFYTTKAKGTGIGLVLAQQIATAHHGSVTLHSARSGTGCVAQLNLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYH8</accession>
    <name>E8WYH8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2861</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581199.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2861"/>
    <dbReference type="EnsemblBacteria" id="ADW69884">
        <property type="protein sequence ID" value="ADW69884"/>
        <property type="gene ID" value="AciX9_2861"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2861"/>
    <dbReference type="eggNOG" id="ENOG5032RTV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641376_0_0_0"/>
    <dbReference type="OMA" id="SKYGCAA"/>
    <dbReference type="OrthoDB" id="1629957at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17191" checksum="C0DAA93D59AE1E12" modified="2011-04-05" version="1">MAKKSQSRTFNDVLALLGSQKFDVAAAHEGARRTAGAVRISKYGCAAEIAAATIAPAAFDGAASMSASSKPSGSSAMMLARPGWLLNGEITRLVDKGYQKFLKSTKLEIPATADHLRALHDFTTELNAATGEMNLFNESLGTTSDKYEYDRVLGRPDQPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYJ4</accession>
    <name>E8WYJ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0520"/>
    <dbReference type="EnsemblBacteria" id="ADW67592">
        <property type="protein sequence ID" value="ADW67592"/>
        <property type="gene ID" value="AciX9_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0520"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043515_1_0_0"/>
    <dbReference type="OMA" id="AVANIWY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233985" evidence="1">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="337" mass="36086" checksum="E66157D7445FE21C" modified="2011-04-05" version="1">MKKLFAGSLLLTAMTTASAFGQGNAPLKLVKTVTLPGYSGDFDHFAIDRQRGRFLLAAEDHATLEIFDLKTGDHLKTIKGFGAPHTILIRPSSSNILVTDSDQMTSVLNAETYEKNGSVTLTPGADSAGYDAVANIWYVVTGGKDVKMTTAEIEAINPDTGKKLSEIKFNDNHVEAMAIEKGGDRLFINLAQTNKLAVVNRKTMKEIAEWPVPPAKGNAMVAFDEAAKRLYVVCRDPGMVVVMNSDTGAVVSTAPAPLRADEVMLDIPSHRFYVPGGEGYIGVYDTSNPNSVKMIAKVLSAPGAKTAVLLPDMKKMLVAASPGDTKNVAKVLTFQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK5</accession>
    <name>E8WYK5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alaS</name>
        <name evidence="12" type="ordered locus">AciX9_0531</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578931.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0531"/>
    <dbReference type="EnsemblBacteria" id="ADW67603">
        <property type="protein sequence ID" value="ADW67603"/>
        <property type="gene ID" value="AciX9_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0531"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_0"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="4"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW67603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="941" mass="102601" checksum="ACB55252D7D99486" modified="2011-04-05" version="1">MEYRSGSQIREDFLRFFEGKAHRRVHSSSLVPANDPTLLFTNAGMNQFKDVFLGAEKRDYSRAASSQKCVRAGGKHNDLENVGFTRRHHTFFEMLGNFSFGDYFKKDAIAYAWELLTSAAWFAIDKEKLYVTIFEGDEKVPRDEEAYQFWLEVGVPAERIFELGAKDNFWAMGDTGPCGPCSEIYYDLGLAASESGADVPFGEDDQRYMEIWNLVFMQFERASDGTLTPLPKPSIDTGMGLERVSCVLQGVMSNYDTDLFIPLIKRAAELTLKPTSENPDMGHPVGDEKGAASLRIIADHARAATFLIADGVQPANEGRGYVLRKILRRGIRHGRLLGQEQPFMFEMVKAVRDEMKVAYPELVEHAERVSKVVLAEEEQFARVIEKAMNELDRTLDAIKQLPSVLDRWNKTPESAPDYKEAEAAFWVTFELVHRTVNKNEARPKSRHGMFPGRTAFFFFETYGLPIDFMEDAARDAGIELDRAEFEKAKIEEQERARASWKGGSQKTASPVYRELAKTEFEGYSALRVDGARVIALVKDGVGVHVLSPGEEGEVVLDATSFYADSGGQVGDVGWLYAADHTTVLAEVRGANKPVQGVFAHKVIAKVAIAVGDEVDTVVNGEVRAATMRNHTGTHLLHAALREVLGKHVKQAGSLVNRDRLRFDFSHFTGVAEEELREIETIVNAQVLKNTPVETLVDVPIDVAVNDYGAMALFGEKYGDKVRVVRIGEFSTELCGGTHTLATGEIGVIKLVGESSVASGVRRLEAISGTGALDEFRRGFEVSRVVPGGAAGLRDRLASDEEEIKKLRRELDGLRLKAAQAATADAAAGAIEVKGVKVLAKRLDGVDKAQMRELVDQLRGKLGSGVVVLGAATAEGKVALIVGVTKDLTGKVQAGKIVGLLAALVGGKGGGRPDLAEAGGSDVSQLDAALGKAGEVVGGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYQ0</accession>
    <name>E8WYQ0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0577</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578976.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0577"/>
    <dbReference type="EnsemblBacteria" id="ADW67648">
        <property type="protein sequence ID" value="ADW67648"/>
        <property type="gene ID" value="AciX9_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0577"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_0"/>
    <dbReference type="OMA" id="WTFQAST"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="182"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="500" mass="56320" checksum="2AB6182F0020B5B3" modified="2011-04-05" version="1">MLSRGKVVLFYPPYDGPPLGAPLSLLALAGTLREANFEVVLIDAAIEDHHLDRIEEECASALCIGISVLTGPMIRGAIIAAQHVKRTNPSVSVVFGGWHPTLCPESTLREPYVDIVVRGQGELTIVELAVALAEKKPLDFITGISWKKNGRLIENFERRVQPVDTFAQPAFDMTDFDAYEKKSGKRELAYATSIGCPYACNYCTDMVVYKRRFNAYAAEHVVAELTGLVKRYRITHVALLDSNFPVDLKRAIAIARGIVDSGVKFAWTFQASTDFICRMSQEEVQLLADSGVRYMGFGTESTSKAVLKMMNKRHQRVDEMYETARKAELAGIRVNFNLILGYPGETEADRLETFRTMSDIGRHFKNVRFSPNIFTPYPGIPIWPQLRELGVVEPQTLEEWETMPLGANLLPWLRGRELARLNRMLAYFLLLSQVSRRRSSSSTLRRILGMLITAPIRWRLTSSRFSFPWEIWLSQLSEQIVKRRSLITGQALPAVESANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ07</accession>
    <name>E8WZ07_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2899</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581237.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2899"/>
    <dbReference type="EnsemblBacteria" id="ADW69922">
        <property type="protein sequence ID" value="ADW69922"/>
        <property type="gene ID" value="AciX9_2899"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2899"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="HYGSKEP"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233998" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="464"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1153" mass="122790" checksum="1A4F03A27F542BB9" modified="2011-04-05" version="1">MILNDRRSRLLFLASTPIIAVSSMMAQSNYGAVRGIVTDVSGSIVSKAEVTITSEATKLTRTTTANGSGEYVFNAVDPGKYTVSVSGSGFMKTDETGVVVDSGNTIALDLKLRIGSANDSIEVSGATPIVDNGTSYNGQLIDAQKLQNLPNPGRNPFLFSKLDNNVTAVGDPRFVRFQDQSGSSTISIAGAPLSSNNYSIDGVPITDFSNRAVIIPSIEAVEEVKVQANTYDAEIGRTSGGMFNTSLRAGSSTLHGVLQGETRQTNWGANLFFNNRTPTTVNGVLLPQTPRGAAEFYSYVGAIGGPIPLPHILGGNNKTFFWIAEEGYRQRSPLTASNAFIVPTVLQRSGNFSEIGTVTGSGAAAVCASGICIKDPLTGQYFTNNTITASRINPVGQALVNAYPQPNTSITAYGTPNFNGQDTLGDRADEFDGKVSHEFSTRWLAEFYYLHYGSKEPGGNALTTAAGSSSSYLLYRKVDAIGIQNTITITPTTLLTVGFGFNRFPNNTLDISNGFNQSTLGFPANYAAAISKPAFPEITTDSGLSQEGTANSGPAVYFSRNFVVGLSKSLGKHSLKTGYVYRAISLSFTNIANGNGVFAFDKTLSGATAADMLLGYPTSGSLVIPAPLAITTAYQATYLQDDYRVTPKLTLNLGIRYEYEPGVHERSNHYSVGFDRNATYNAFNSGVTAKGGVEFAGQNGYPTSTGNMGSKWSPRAGFAYGLTPMTVIKGGAGVFYAPIVYSSTPALAPGYVVTNSIASQTGVPTISLSNPFPNLQTKATGNSNGLSTGIGSTLNVIDQSRRAPLYESYSLALEQQFAGGIALKIAYVGGHARNFYNGENINQLPDSQYALGTALSTKVTNKYAGLGSFGTGLVNTYQTLLPFPQFQSITDSISNARSDYNSLDVKIQKNFSKGVTILAAYTWSSNWDNIWGGSSSSTLNPGNNGPQDVYNISNEYSRSINDIPQRFTVALTYELPFGKGKQFLSGANRLVDAVVGGWRFNDITIVQNGSPLPLTQSTNFNSSLGNLTQRPTINPGIISACYTGSPESRISSSVNRPYFNPKGFTTTPAYAYGNQPRTSNCYGPGYLNSDLSLNKDFKLTERIHAEFRAEALNAFNTPEFNAPNVAVDSSSAGQITGTLGFPRLIQLGGRLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ23</accession>
    <name>E8WZ23_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2915</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2915"/>
    <dbReference type="EnsemblBacteria" id="ADW69938">
        <property type="protein sequence ID" value="ADW69938"/>
        <property type="gene ID" value="AciX9_2915"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2915"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_1_4_0"/>
    <dbReference type="OMA" id="GGMCYSI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="17"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="44088" checksum="BFF31774E32C4AAB" modified="2011-04-05" version="1">MIIDRFRRKTRDGRWVPEIDGLRFIAIFSVFVFHIMGELLNRSGRIIPIEPRFDTLSRILANGDRGVVIFFVISGTILALPYARQFLLGGKPVSLRKYYMRRLTRLEPPYILAMLLIFAMETVYQHGSSVPMGGHLLASLLYQHSLIFGQMSPINMVTWSLEVEIQFYVFAPLLMQLFRIKHTLSRRLVLLGVVLAIGLCQGPFSTIPRFAMSILYYLQYFLAGLLVADIFTLDLETMRAWWVWDVVGIGALGILFWAGHDEARPHVVLPVVIGALCVAAMRSVVLRRFLGNHWIAVLGGMCYSIYLLHDAFIAVLFKVTRMAILPAASFPVNLAIQMLVTGVPAVALCVVFFVLVERPCMDPDWPSKLWTKMTGRPGREAKALDTAGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ55</accession>
    <name>E8WZ55_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0586</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578985.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0586"/>
    <dbReference type="EnsemblBacteria" id="ADW67657">
        <property type="protein sequence ID" value="ADW67657"/>
        <property type="gene ID" value="AciX9_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0586"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051175_1_0_0"/>
    <dbReference type="OMA" id="YHKRYRI"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="434" mass="47511" checksum="B95BAAFA2CA33FB7" modified="2011-04-05" version="1">MTTSTLTPTSPDASATLRARQANWVANATLLWDKRTRIARTAVISLVAGLAIAFAIPKEYEASARIMPPDQGGGGAALLSALAGHGGGALGSLGSLAGGLLGGHNTSALFVDLLQSGTVSSHLIDRFQLQHAYHKRYRIDTAKYLARHTKIVEDKKSGVISITVEDTQPQRARDLTQAYLEELNKMVTQTSISSARQERIFIERRLQSVQRDLENAQLAMSDFSSSHTTIDIKEQTRAMVDAAAKLQGQLIVGQSELGSLEQIYGDGNVRVRAAQARVSALQKDLKQMSGTDAPLPAQAQKASSDELYPPLRQLPRLAVPYADLYRRVRVQETVFELLTQEYEMARIQEAKDIPVISVIDAPGLPEKKSYPPRLLVALGIMMVSCIAMSALILLRRRWEQMSEADPRKVLMRTVQGTLPLSMRGEGGRTEMETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ97</accession>
    <name>E8WZ97_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0628</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579027.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0628"/>
    <dbReference type="EnsemblBacteria" id="ADW67699">
        <property type="protein sequence ID" value="ADW67699"/>
        <property type="gene ID" value="AciX9_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0628"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516554_0_0_0"/>
    <dbReference type="OMA" id="GLASCEW"/>
    <dbReference type="OrthoDB" id="1957454at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="184"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="59198" checksum="8EB50BAD7C7951E7" modified="2011-04-05" version="1">MKSVLRSASLAFALTTLYLLNLTGPLISPEHDLAFHFPAAASILFLPVLIDIALLFLVLTAVLLAAARNRRVQLVVWSILLLPIPAILLSTIASFSGKRVPQPLTLAFAFLPILALLFIAVRLRHLIPRFRRLRPAVESIFAFIAVSGLIIVAELLWFNYQARNNNAPPVLHVSTVSQPAPNRIIWLLLDELSYDQLYEHRYPGLQLPAFDRLAAQSSLLTHVEPANEFTRVAVPSLLTGEILEDTRQSSDGLHLGLKDDETAQWSRLDPANTVFADALAAHYSTSAVGWYEPYCRIFPSVLDHCFWIYGDDIPGGISARRTTSANVVASFQTLGRHVLENLHLGRTSEDQDQALRDVHGHRADYQALLTAGDAALADPSSTFLYLHMPIPHPFGFYDRRTHSFPDHQTSYLDNLALADEYLAHVRQILEKQAQWDNATVIVMGDHSWRTSFVWSVSPHWTPEEDLASHHANYDERPAYLIKLPHQQTPTRIGHRFEASHTRPLIKALLTHQLQTPADLTDWIDSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZC1</accession>
    <name>E8WZC1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0652</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0652"/>
    <dbReference type="EnsemblBacteria" id="ADW67723">
        <property type="protein sequence ID" value="ADW67723"/>
        <property type="gene ID" value="AciX9_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0652"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045520_1_0_0"/>
    <dbReference type="OMA" id="FKCIEGW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="185"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="325" mass="35928" checksum="C4C688472FE19CC3" modified="2011-04-05" version="1">MAAAGAAGGYGFYRWLDRAPGLEGIPRPLRKTFEFDEAVARGVFDERGLAPTYSLKHATELKINGNFGLKQKIELDSFRLQMVGVEGADKLPQYVKDVTAWEYKYAEDTAKELGENVKTRPKAAGAAPAPAPAAGAPAAPDRSAMPPEFQKAFAAIDKENDGKPQRGQEEAGESDSTLDPGTPGLLLTMDDVLKMPRHEMVTQFKCIEGWSQIVQWGGVRLGDLLTAYPPARNADGSLPKYVYMETPNGDYYTGYEMAECHHPQSLLVTEMSGKPITQEHGAPMRLHMPIKYGYKQIKRIGLIAYTDDRPDDYWTKLGYDWYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZD9</accession>
    <name>E8WZD9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580146.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1779"/>
    <dbReference type="EnsemblBacteria" id="ADW68827">
        <property type="protein sequence ID" value="ADW68827"/>
        <property type="gene ID" value="AciX9_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1779"/>
    <dbReference type="eggNOG" id="ENOG502ZBVN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132521_0_0_0"/>
    <dbReference type="OMA" id="HHIEGRP"/>
    <dbReference type="OrthoDB" id="1905527at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009474">
        <property type="entry name" value="YphP/YqiW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40052">
        <property type="entry name" value="PTHR40052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06491">
        <property type="entry name" value="Disulph_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04191">
        <property type="entry name" value="YphP_YqiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="14981" checksum="47DD25C798EFCD27" modified="2011-04-05" version="1">MYPEIMVIPMREELVRAGVSEARTAADVDTAVAQSGTTMLIVNSICGCAAGKMRPGVRLAMQHTTKPDHAVTVFAGQDREATEKARGYFGGHPPTSPAIAILRDGQLVYLMQRSAIETSTAPAIAQELARAFDAYCAKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF4</accession>
    <name>E8WZF4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1794</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580161.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1794"/>
    <dbReference type="EnsemblBacteria" id="ADW68842">
        <property type="protein sequence ID" value="ADW68842"/>
        <property type="gene ID" value="AciX9_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1794"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_0"/>
    <dbReference type="OMA" id="YLTMEDV"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="304"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="471" mass="51798" checksum="95EF848880768437" modified="2011-04-05" version="1">MFEWTLIRGIMVAFFILANSFFVAAEFALVSIRETRVEQLISLGRPGARTVLKLKQSMDDFLPAVQFGVTLASLALGWIGEPAVATIIEDLAAHILPHLPPHIQLYSNAAAIVIAFGIITYFEVLLGELVPKALALQRAERIALAVAGPMDVFIRMTRPAVRLMNTSATLVLRVFKAPLTGEGAVHSPEELKLIASATRRMGLLPPFQEEIIHRAIELSHVVVREIMTPRGNIFSLPASLRLEQASARIVEEQHSRIPIFDPERGPEHIIGIVHSKDVSRLMHFRGNALALGGRGDSTLTLREIMRDALFVPETKLAVELLQEFQERRRQMAIVVDEFGTTVGVVTAEDALEQIVGELEDEFDTGPSRVALSSTGIITLDGSTTLRDLSTRLGWAFPREPGVETLAGFVLNELGHIPVVGECVMHEGQSFRVEEMSGHRIARVRVDDNAISLERRASELQATEDDGLEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZG7</accession>
    <name>E8WZG7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1807</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580174.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1807"/>
    <dbReference type="EnsemblBacteria" id="ADW68855">
        <property type="protein sequence ID" value="ADW68855"/>
        <property type="gene ID" value="AciX9_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1807"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="PSMRCGV"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="599" mass="63470" checksum="96C161920ED3D346" modified="2011-04-05" version="1">MSDEKVSAKTRREFLAGASVSVVGLGVAMGQAATPGAPPAFGTAPAVGPEVTVATFAEAEKVVQAPLTVKDRAEAAGNWRQSMAALYERRVGPRKVAIPDGVAPYSATSGRGFHGDVGVANTKYTLSEAAPALPVTDAEIAFAPVFTLMQWIAGKKITSERLTSIYLDRIRKYNGELRCVITATPEIAMKQARAADAEIAAGRYKGPLHGIPWGGKDLMDTAGIRTTYGADCFQHRVPEKDAAVVAKLHEAGAVMIAKLSLGALALNDVWFGGQTMNPWLLEEGSSGSSAGPGSATAAGLVGFSIGSETGGSIVSPTMRCGVNGLRPTFGRVPRTGAMTLCWSLDKLGPMCRSVQDTMLLLQAIHGEDAGDVASVSASLAYAPAEPVKGLKVGYFPGWMKEAPATNVDRHALEVITKLGMTAVPVTLPDWPYGSLNTILFAEAAAAFEEITLDHRVDQLKAQVPDAWPNTFRQARFLSAVDFVQADRMRRMVAMEMARVMGEVDLLLVPSLRDEMLTISNNTGHPSLTLRAGFVEVNETRSDWAPGGEWSSKKLKAPHKVPHGVTLIGRLFDEGTIVRVGMAMEKEFGVSGAVPPGFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZK1</accession>
    <name>E8WZK1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ordered locus">AciX9_2952</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581290.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2952"/>
    <dbReference type="EnsemblBacteria" id="ADW69975">
        <property type="protein sequence ID" value="ADW69975"/>
        <property type="gene ID" value="AciX9_2952"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2952"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_0"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="274" mass="30109" checksum="8D9784346D571366" modified="2011-04-05" version="1">MPIKSFRPITPTLRFQTKLVNDDLTTDKPHKPLLAVKPRTGGRNNTGGMKIRHQGGGHKQKLRLIDFKREKFGIPGTVATIEYDPNRSSRIALIHYADGEKRYIIQPVGLKVGQKIMSGPDADILVGNALPLRLIPTGTIVHNIELRPGKGAQMARSAGAQVNLIAKEGDYALLKLPSSETRRVLVDCMATIGQVGNTDHENVTIGKAGRNRWKGIRPANRGVSMNPVDHPHGGGEGKTSGGRHPVTPWGQPTRGYKTRNNKRTDVFIVNRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS3</accession>
    <name>E8WZS3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0664</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579062.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0664"/>
    <dbReference type="EnsemblBacteria" id="ADW67734">
        <property type="protein sequence ID" value="ADW67734"/>
        <property type="gene ID" value="AciX9_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0664"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131518_3_1_0"/>
    <dbReference type="OMA" id="WRKKIDA"/>
    <dbReference type="OrthoDB" id="1980002at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9903" checksum="4C6DE867C072FBC8" modified="2011-04-05" version="1">MEISDWRNKIDELDEQIVELISKRAEAAKAIGELKAKTAMPIYEPQREKDVFEHVKKVNPGPLADAELIHVYERVMDVMRTLQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV6</accession>
    <name>E8WZV6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0697</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579095.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0697"/>
    <dbReference type="EnsemblBacteria" id="ADW67767">
        <property type="protein sequence ID" value="ADW67767"/>
        <property type="gene ID" value="AciX9_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0697"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="FEKFWFS"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="141" mass="15889" checksum="C09A935F3551C371" modified="2011-04-05" version="1">MAEATKLILLVEDDPDHELLTIRALKKSNIANEVKVARDGEEAINLLFGAEPVKPQVILLDLKLPKVDGLEVLRRIRESDSTKMLPVVVLTSSDEERDVVRSYQLGVNSYIRKPVSFDDFAEATRQLGMYWLVLNECPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X059</accession>
    <name>E8X059_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581354.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3019"/>
    <dbReference type="EnsemblBacteria" id="ADW70040">
        <property type="protein sequence ID" value="ADW70040"/>
        <property type="gene ID" value="AciX9_3019"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3019"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459363_0_0_0"/>
    <dbReference type="OMA" id="PLACIEI"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="20184" checksum="7F7E6C1D6A98CA0D" modified="2011-04-05" version="1">MVASTQIIPASISMEEYLHTAYHPDCDFVDGVLEKRNGGEYEHSNLQAALGAWFFNRGREWGVRVLTEQRTRVGETRVRIADVCIIQRGGAIERVRVTPPLLCIEILSREDRITGTIRVLDDYLAMGVKNLWVFDPVDRVAMTYGAKGLKIAEGTRLEIAGTPIYLDCLSFLRCWIKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X082</accession>
    <name>E8X082_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3043</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581377.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3043"/>
    <dbReference type="EnsemblBacteria" id="ADW70063">
        <property type="protein sequence ID" value="ADW70063"/>
        <property type="gene ID" value="AciX9_3043"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3043"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_0"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="98" mass="10707" checksum="8195560962E54F16" modified="2011-04-05" version="1">MEQAECVRHYLVKGRVQGVGFRWFVHREAAELGLRGWVKNTDAGHVEIVVAGDAESIAELNAVLHKGSRGSRVDAVIEHALTDEEGTALGPFEIEGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E6</accession>
    <name>E8X0E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0740"/>
    <dbReference type="EnsemblBacteria" id="ADW67810">
        <property type="protein sequence ID" value="ADW67810"/>
        <property type="gene ID" value="AciX9_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0740"/>
    <dbReference type="eggNOG" id="ENOG5032NB1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161157_0_0_0"/>
    <dbReference type="OMA" id="IWQDVYH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038493">
        <property type="entry name" value="MqsR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031451">
        <property type="entry name" value="MqsR_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15723">
        <property type="entry name" value="MqsR_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9189" checksum="3A9A3296D8CAFCAB" modified="2011-04-05" version="1">MEKRTPHCPLAKVKALLAEGKVRTTFTALAGGAALGLDFAGMLAVVHALSMADFYKSMTTHADHRVWQDVYRTVVKASRVLSGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F6</accession>
    <name>E8X0F6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0750"/>
    <dbReference type="EnsemblBacteria" id="ADW67820">
        <property type="protein sequence ID" value="ADW67820"/>
        <property type="gene ID" value="AciX9_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0750"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064253_0_0_0"/>
    <dbReference type="OMA" id="PNPMDFS"/>
    <dbReference type="OrthoDB" id="1574236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="32199" checksum="BBB5319A7E6669FC" modified="2011-04-05" version="1">MLVRSEFAIEFYLPQSVAMIGLLRLHSSFDPLVREPEVLEAVHLSNGTRTPIAIQEYVDSFGNRCSRFLAPQGHLALSGSSVVDIDFFAVEIDTQAQQHPIEDLPPEVLQFLLSSRYCQVDQMSLVAGDLFGHTTPGWTRAIAIRDWVHNHVRFDYKSARSTKTALDVFTERVGVCRDFQHLAVTLSRAMNIPSRYVTGYLGDIKRPYSGAGDFSAWYEVFLDGKWWTMDARHNDGRMGRVLMAVGRDATDVAITTSFGIADLNSFQVDSYEIDAQNNRVPLPQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0H6</accession>
    <name>E8X0H6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0771"/>
    <dbReference type="EnsemblBacteria" id="ADW67840">
        <property type="protein sequence ID" value="ADW67840"/>
        <property type="gene ID" value="AciX9_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0771"/>
    <dbReference type="HOGENOM" id="CLU_3310495_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="39" mass="3749" checksum="EB04E638D412CB3B" modified="2011-04-05" version="1">MGSGCALAARQTAGGCNGNDPGLKPTFFVGSGRGPEGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Q6</accession>
    <name>E8X0Q6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage major capsid protein, HK97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1961</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580326.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1961"/>
    <dbReference type="EnsemblBacteria" id="ADW69007">
        <property type="protein sequence ID" value="ADW69007"/>
        <property type="gene ID" value="AciX9_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1961"/>
    <dbReference type="eggNOG" id="COG4653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701632_0_0_0"/>
    <dbReference type="OMA" id="GDFRRGY"/>
    <dbReference type="OrthoDB" id="755947at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="388" mass="41657" checksum="F458456D5DBF0E71" modified="2011-04-05" version="1">MSMPALQEQRNKLMTDAAVILRSDAPTADQIESANKMIADAGELEQRVATLKQVEAYEAEQRAFVPAPRPTGEQSKDEQRTRAVDALRSYMIRDRVEPEYRDLLTTSSASAGVTIPQMFSPVLVQALKDYAPVLDAVNVITTNKNGAPMKMNLINYTGTILPVVAEGTQFPEIDPAFTSQILNVDKLGGEVKISNEMLDDSEFDLGGWLTQAWQNTYGYSLEHYVTAGDGSNIASLLAVAATGTTSAAAGVITYPDIAALYGGLTAAYARNGSFMMSTATRAALMALTATTGQSIFNTDPTNGPFSSIFGRPIYINDSMPTLAAGNKAILFGDFKKAYTLRLDGAPTIKRLDERYADTDEVGFIIRSRVGGITMNAGIAPVIALTVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0S9</accession>
    <name>E8X0S9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3093</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3093"/>
    <dbReference type="EnsemblBacteria" id="ADW70113">
        <property type="protein sequence ID" value="ADW70113"/>
        <property type="gene ID" value="AciX9_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3093"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053531_0_0_0"/>
    <dbReference type="OMA" id="PWTHAGV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="300" mass="32478" checksum="B4223494C1C4F46A" modified="2011-04-05" version="1">MTDTDQALISTAQIVLEETETKVTRSATSDASGSFSFVAVPPGKYMLRISAPGFSQWKVEDIILHADDALALPTVELGVEEITASVNAITQEDLAEQQISAEEHQRILGILPNFYVSYVSNAAPLTRKQKFKLAFVVSTDPLTFMTTGVTAGIEQAQGDFSGYGPGISGYAQRYAATYGNRLSATFLGSAFFPSIFHQDPRYFYRGHGRIVTRALYAISTTVICKGDNGHFQPNYSNVLGNLGAAFIAGTYYPRSDQHAVQVTVSDTLLGVAYGSFGTLFQEFLLRHVTHGAPPITPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0T3</accession>
    <name>E8X0T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3097</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581431.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3097"/>
    <dbReference type="EnsemblBacteria" id="ADW70117">
        <property type="protein sequence ID" value="ADW70117"/>
        <property type="gene ID" value="AciX9_3097"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3097"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_1_0"/>
    <dbReference type="OMA" id="YNAKQQL"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230144" evidence="3">
        <location>
            <begin position="27"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="53602" checksum="868AB2FB3819C81D" modified="2011-04-05" version="1">MKNKLLLNQIALLGAALVFLAPVIDAQSTSSNSPLSNSIATPRPFDPGTNTTNPSALAVQAQNPYLGSVATRPLTLGVLPLSLTEVVDLGLKANLGLIDTEQEHAQSRAARMRALSVLLPQLNAELIGAFRDFPLNTIGAQKLGLPNMIGNFNYQTADISLQQKVLDISALHEVKASHAEEQVSEASLADARNIVVLASTSAYLQVLASQSRVQEAQAEQASSQALESLLKDRVKREVSPEIDAIRATVTRESAEQRLALAQVRLEKDKLGLTRIIGLPVEQEFTLTTDLGFTKAPQQDLDTLVQEATASRQDLKAAAARVEYSKQLVKAQTAKRLPELEIKANGGETGVNFGHAYGTYEVAGRLSVPIFTGRRIEADVLTAEATLHRREAEYQDLQQRTRYDVRSAVLDLRAADTSVEVAKTNLHLAKEGLRQAKDRFEAGVSNSLELIQAQQAVASAEDNDIASVYAHNLAKLLLVRSTGTAERDYTTYLGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U4</accession>
    <name>E8X0U4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3112</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581442.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3112"/>
    <dbReference type="EnsemblBacteria" id="ADW70128">
        <property type="protein sequence ID" value="ADW70128"/>
        <property type="gene ID" value="AciX9_3112"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3112"/>
    <dbReference type="eggNOG" id="ENOG5033QZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605152_0_0_0"/>
    <dbReference type="OrthoDB" id="1812247at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="51601" checksum="FDBBDD23653242FE" modified="2011-04-05" version="1">MTDNPYARWLQTDFELCNPVVPGDELSEIQGQVILRVHQVMGSGPKPTMYMDLEQLQVVDYLAFEGLSKAQREFIAGLHAAEPIRPEEMIFLALRSLFQYSWPAPTSNNDIRFAASYDHVLHQVLVQTALDLAKQFSSPTALLPYWGRLAFLRVMGDLPSEHVSRFGLDRVACTLVKKAKFNATTFALENDPVIGMNYALEPILKHLNRYLMHYQSTREMAGPNRLSRAWEGIAPIVLHFWSEISATKLLQSSLILFEDKVGTMVHWFTNDQVDFVLMHELGHVALAHPQRLQAERKAGRDVSVLRHEFEFAADSFALGLMRSKLVKRVRSVTDSSRTDPAESQVEHVVESLHDYQRALGSVYLLFLYMDFIQRAGELLRDRLGTQLNIRSQMDTHPRAQARLERLELMNLGEYLYTSPIERYAREFLDAVLEYATTLSDEELLASVTRNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1B1</accession>
    <name>E8X1B1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2020"/>
    <dbReference type="EnsemblBacteria" id="ADW69065">
        <property type="protein sequence ID" value="ADW69065"/>
        <property type="gene ID" value="AciX9_2020"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2020"/>
    <dbReference type="HOGENOM" id="CLU_1213424_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25425" checksum="58BC4F4B2BE3B600" modified="2011-04-05" version="1">MPTETATLTDARISPNRLCYVAPKPYEPMPVIISVTSSPTLLSYSLTGPAVDAHRYCKACTVGPDDGLLEAVATALGFLTPRRAAHLLKIQRNYRAALKLYENPTFLPGTRPDPKDLPISIRTSSQRLADAGLALCEMTFNDVPEGLATRLWMELNRFDVTWVLLPIDAAELVTLQRWGSIHFRPGEAFKRGEETRRYFREAQATFERPDQEDSHPVPPADLDESSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1C5</accession>
    <name>E8X1C5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2034</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580396.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2034"/>
    <dbReference type="EnsemblBacteria" id="ADW69079">
        <property type="protein sequence ID" value="ADW69079"/>
        <property type="gene ID" value="AciX9_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2034"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027852_0_0_0"/>
    <dbReference type="OMA" id="TPLWFYV"/>
    <dbReference type="OrthoDB" id="40466at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="550" mass="60012" checksum="E9339A3C66B0AD1D" modified="2011-04-05" version="1">MPIANSRTESLQQAQFRAVQAITVKPEVLDESNPTRQVLTGLMKHGGVYTLLDTEMMTARLVPMLTRGSGAAAMSAEDASTFVNGLGNTMASFFQHLVPGKAYTIPSSLMSHIAFPGTGVSYSDPGLEQSDPGVFESPEVPAAFTFVGQFIDHDLTMNAVDLFEVQTDEVANTASPLIDLDSVYGANRTKLTAPFSKIFHADGRFRMVDRGGYEDLVRDEVGNALIGDQRNDENQMILQIHLLVMKVHNKLMAGGLGFEEAYRETLFNWQSVLLTDYLPAILEPATLAWLLGEIGKPDFGEFKYKPWKNLVDGKLAASMPHEFAIGFRFGHSQLRFGLRVNPGVGGMVRLFDNSLTSSGGKTSTGAVKNLFSDLRGSQELVAEHVIDWGTFLGGATPLRSNRIDGKVTSVVFDLPESAIPDDIKYIGNLPQRNLIRSRQVGLCAGEDLAKFYGIERLATRKIEPDEAAHHLYMEKGHFRTPLWYYILKEAEAVGGPKSSRLGALGSRLIGEVIVGAIGFAPTNVLAEPGWKSSVTGSREVSLLELAEWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D0</accession>
    <name>E8X1D0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">AciX9_2039</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2039"/>
    <dbReference type="EnsemblBacteria" id="ADW69084">
        <property type="protein sequence ID" value="ADW69084"/>
        <property type="gene ID" value="AciX9_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2039"/>
    <dbReference type="HOGENOM" id="CLU_2788057_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ADW69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7109" checksum="C5B281495FB8BB7B" modified="2011-04-05" version="1">MVQSVVICGAIVVFSLHRNAAIPIAVTLLTTTACAAYLNHRIHGITGDCFGTTTQLVEIAVLTAGAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1D6</accession>
    <name>E8X1D6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580407.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2045"/>
    <dbReference type="EnsemblBacteria" id="ADW69090">
        <property type="protein sequence ID" value="ADW69090"/>
        <property type="gene ID" value="AciX9_2045"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2045"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_0"/>
    <dbReference type="OMA" id="KRVDMFP"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="415" mass="45135" checksum="D41CAFC6C2F442F9" modified="2011-04-05" version="1">MNLPAHGGQLRRIAAHYGIPAHEILDFSANINPEGPPASVLAALHRALEDPATLTNYPDLDLQALKQSIADHLNQAAVILSAAKNLGSSSEAAGSLRAPSIRSLTPNGWEVSSPPATSITPQNLSIANGFVPLLEATIRTRKIRRCLLPIPSFSEYRRTLELNGVEVIPYPLPQNRVPHVPLQGRGFSGSEQPFHYNPEALLSTLNQTNSDAILLANPQNPSGHLTPAAVLSDLIANTQATILLDEAFVDYAPTESLTTAPLTHPNLIVFRSVTKFFAMPGLRVAYCVSHPDTARQINEILPPWPITTLSTHAVQAALADEPYHHLTRTLNQTRRESLSTALTQLGITPYPAAANFLLLPLPSDAQQIWQSLLTDHQIHLRTCTNFESLPGPHLRTAIRTEPENARLITALRAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1E0</accession>
    <name>E8X1E0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2049</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580411.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2049"/>
    <dbReference type="EnsemblBacteria" id="ADW69094">
        <property type="protein sequence ID" value="ADW69094"/>
        <property type="gene ID" value="AciX9_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2049"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027424_1_0_0"/>
    <dbReference type="OMA" id="LTHWVAD"/>
    <dbReference type="OrthoDB" id="956262at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234068" evidence="1">
        <location>
            <begin position="30"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="3">
        <location>
            <begin position="68"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="285"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="661" mass="73356" checksum="7D54191F2FBC3DED" modified="2011-04-05" version="1">MSLCSFPSELFCRVLLVATLSLCTVPAFASRDSVPDWVAAAAAKPMATYSAETSAVVLLDDTTLTVGADGKGVEHRRHVVKILRPNGRDEGVVWIPYDKDTKILSLHVWSIAPDGKQYAVKDNEMVDVGYPGQGSLYEDIKMRAVRAPGRDPGGVIAYEYDQRKEPYLHEETWMFQQEIPVANQSFTLELPPGYTYGTVWAHHDQQKAADLEHQRYRWEMNATPGIDLDRVPMHPSELALAGRMTVHYAPVGTSADSLATWRGIGEWYEPLMRDRVLSTPEIAAKAAALTSGKTDFYDKTEAIGDYVQAQIRYFVIEMGIGGQQPHPAADIFRNGYGDCKDKATLLSAMLSSVGVHSTLMAVDHRRGVVDPLAPSIFGDHMIAAIEIPKGYESAKLRSVITAKTGKRYLIFDPTWDKTAFGQLEYNLQGGYGVLFEGKDTEIVELPVLSPELNSVKRSGTFQLAVDGTLKGSLTEKRYGDVSERMRSLYTESDAKQQRSFLDESLSHDFTTVDVEDVKVENAASLSKELTTSYELTAGRYSRSMGPLLMVRPRVLGTEGLPVDRKVRLVPIDLRGTRLIHDDFTIELPDGFAVDELPEPVKLDMGFASYESSSQLTGKTLHYSRTYTVKQVSLPADRYGDLQKLALAIENDEQNHAVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F9</accession>
    <name>E8X1F9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3183</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581506.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3183"/>
    <dbReference type="EnsemblBacteria" id="ADW70194">
        <property type="protein sequence ID" value="ADW70194"/>
        <property type="gene ID" value="AciX9_3183"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3183"/>
    <dbReference type="eggNOG" id="ENOG5033PW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911428_0_0_0"/>
    <dbReference type="OMA" id="YVWAGFM"/>
    <dbReference type="OrthoDB" id="912157at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030255">
        <property type="term" value="P:protein secretion by the type IV secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007688">
        <property type="entry name" value="Conjugal_tfr_TrbL/VirB6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04610">
        <property type="entry name" value="TrbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="305" mass="33059" checksum="3C698600CA068D5E" modified="2011-04-05" version="1">MSVAVLAQALPTASSGMNWLYQFTNNLTNLTTQNGGALTQLGITELSAIAFFQLVSMVVNWNTSAMTLRFHTHQVRAGDMTNFLMKLIICSLLINYWVTPFPGASFGINHFFSYIAQAMVAAFDQNSLDQLLQLLKTAGDGTAMPSFTAPVQILCYVLVQIMLGLASAILFVINCSAFILYGVTALFGPVFVPLLMTQTFRAKFFHFLDVLISFAMIRAVAAAFIYVWAGFMNGFLQQTFNGNYSMEMWIANLIPCLMVFVAFIINMLFIPSMTQAIFGGAAGMADGVVKVGGTIASIAKVAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M0</accession>
    <name>E8X1M0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3244</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581567.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3244"/>
    <dbReference type="EnsemblBacteria" id="ADW70255">
        <property type="protein sequence ID" value="ADW70255"/>
        <property type="gene ID" value="AciX9_3244"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3244"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_1_0"/>
    <dbReference type="OMA" id="VANINMD"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230568" evidence="2">
        <location>
            <begin position="20"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="137"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="300"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="549" mass="58985" checksum="694224BB4991323C" modified="2011-04-05" version="1">MPRPFLAAALLALPLPLAAQTDLPPAVTAAEANVSADSIRAYDKYLSDDLLEGRYPGQRGGELAAKYIASQFESYGLKPGGDHGTYFQQVDFTSVKADPIKTTFTLVPKSGAPIKLKFADDFVVFNSQLTPSATINAPIVWMGYGITAPEFQWDDYAGIDVKGKVILCIVNDPPSDDPNFFGGKSLTYYGRWTYKFEQAARKGAVGALIIHRTDLAAYGWDVVRNSNSAEKTFLAHDANPRLEAASWIQLDVAKQIFAASGTDLDTEFAAAGKHGFKARELPVKLDATVISTVRNFQSPNVIGILPGTSPAPDQAVIYTGHYDHLGVKADAKPGEDAIFNGAGDNGTGTAMIMEMARAVTSAKLSPPHSMIFAAVTAEEQGLLGSAYLSQHPPLPIGQINLDLNFDEILPFGQGDQLHASGSQRTSFYPTLEATAKRFGYSVPAPRPDTGGGYYRSDHFSFAHAGVPAFSVGQGGTYKGHDAAWSQAQGAAYNKNDYHNVSDNFKPEWDFVGNATLCRLGIELGWKSVTSPPIEWKAGDEFAAARKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1U0</accession>
    <name>E8X1U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0942</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579333.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0942"/>
    <dbReference type="EnsemblBacteria" id="ADW68009">
        <property type="protein sequence ID" value="ADW68009"/>
        <property type="gene ID" value="AciX9_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0942"/>
    <dbReference type="HOGENOM" id="CLU_1765455_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="147" mass="15387" checksum="5CE17184EFEB7788" modified="2011-04-05" version="1">MKMCRFALVGCFLLAGCQSSPKPDTAAGFGTKAVSLRGTYGVAQGGVTEPVLKVDETKTGHAFEERITGEWRLDPNVPHVATESEVKRALGLDSVTGFPVFGLANDQEMLLKVPAGWTHGELAAKSGFILVSGGKAVAAQKIELGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X221</accession>
    <name>E8X221_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581576.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3253"/>
    <dbReference type="EnsemblBacteria" id="ADW70264">
        <property type="protein sequence ID" value="ADW70264"/>
        <property type="gene ID" value="AciX9_3253"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3253"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_35_0_0"/>
    <dbReference type="OMA" id="YIMNMYT"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="159" mass="17998" checksum="A6BABC171561A63A" modified="2011-04-05" version="1">MSSTETLLTRMATPADAVLIAHQRHRMFEDAGQPDAPAMKDMATNFVEWVHPRLADGRYLGWIIEENGEPIAGAGIWLMDFPPHWMDAQPIRAYLLNFYVNPEHRGRGLAKQLLDATLAETRTRGIQVVSLHASKFGKPIYAKNGFEDTNEMMLRNSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X234</accession>
    <name>E8X234_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3266</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3266"/>
    <dbReference type="EnsemblBacteria" id="ADW70277">
        <property type="protein sequence ID" value="ADW70277"/>
        <property type="gene ID" value="AciX9_3266"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3266"/>
    <dbReference type="HOGENOM" id="CLU_1728800_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="16828" checksum="BB69A450986501E3" modified="2011-04-05" version="1">MLADSLNSAIMDANPTMQVSASSNSIADIIIPICFFSAALAVHFRIMSLRLKSLQNLADRYHLMRISNDLPGDFPTDMMDGIGSFNRVSNAFWGSHDADLLLVFDIQIGLGRQSYTRTIVGRRFLSLPAEPKLKSSLSYQQVGQWRVAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X292</accession>
    <name>E8X292_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ordered locus">AciX9_0957</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579348.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0957"/>
    <dbReference type="EnsemblBacteria" id="ADW68024">
        <property type="protein sequence ID" value="ADW68024"/>
        <property type="gene ID" value="AciX9_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0957"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_0"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="638" mass="67890" checksum="82C928F0F4A4ED11" modified="2011-04-05" version="1">MAKIIGIDLGTTNSCVAVMEGGEPKVIANEEGGRTTPSIVAFTKSGERLVGTVAKRQAITNPENTIFSVKRFMGRRSNEINEEMKMVPYKVVAKGDGVNIVAQGKEYTPPEVSAMILQKLKKAAEDYLGTTVTEAVITVPAYFNDAQRQATKDAGKIAGLDVKRIVNEPTAAALAYGLDKKKDETIIVYDFGGGTFDVSVLEVGEGVIEVKSTNGDTHLGGDNLDQRIVDWLITEFKSDTGLDLTAKGNEMALQRLKDAAEKAKIELSTAQESEINLPFITADASGPKHLVRNLTRAKLESLVDDLLQKSVGPCKQALKDAGIDASKINEVVLVGGQTRMPAIQKLVKDLFGKEPNKGVNPDEVVAIGAAVQAGVLAGEVKDLLLLDVTPLTLSIETMGGVATGMITRNTTIPTKKTETFSTAADNQTEVEVHVLQGERPMAAQNRTLGKFKLSGIPTAPRGVPQIEVTFDIDANGILNVTAKDNATGKDQKITITSSSGLSKEEVERMAKDAEAHAAEDKEQRDSVEARNGLDSLVYNVEKMLKDSADKVEASDKVEVEAALAESKTVLEGSPTAAQMNESKEKLTAASHKLAEAMYKAAAAQAPTDGAAASTGTADEAPKHDEGVIDAEYVDVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A6</accession>
    <name>E8X2A6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0971</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579362.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0971"/>
    <dbReference type="EnsemblBacteria" id="ADW68038">
        <property type="protein sequence ID" value="ADW68038"/>
        <property type="gene ID" value="AciX9_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0971"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099465_0_0_0"/>
    <dbReference type="OMA" id="SMYLFFR"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23851" checksum="FF2C10451188624E" modified="2011-04-05" version="1">MTNEPNFDLLARPYRWLEYLTLGPLLQKTRLHHLPALKDCIRALILGDGDGRFTAALLAQNLRLQADAVDLSPAMLALLRKRAQPFAARLTTHQQNVLTLTPTAAPDLVVTHFLLDCLTQPELDSLVLRLVPTLQPGALWLVSDFRIPPGLLHWPARLYIRALYLAFRVLTNLRPTQLPDFAQAFQSAGLHRIAQHHRLFGLLTTELWTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F0</accession>
    <name>E8X2F0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ordered locus">AciX9_2130</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2130"/>
    <dbReference type="EnsemblBacteria" id="ADW69174">
        <property type="protein sequence ID" value="ADW69174"/>
        <property type="gene ID" value="AciX9_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2130"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_0"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="36"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW69174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="247" mass="26589" checksum="A22C7BD1096CED0E" modified="2011-04-05" version="1">MIRFGTPAAKQQMLKQLVCSDAPEQALRYRGARSIAGVDEVGRGALFGPVVAAAVILPAGLASLAKAGLTDSKQLTREERESLDKRIRRMAIAVSVAEIDAETIDRVNIYQATRLAMLQAVEGLAIAPDHLLIDAMVVSHPCPQTKLFYGDALSLSIAAASVVAKVHRDGLMRELDLVHPQYGLASHKGYATPEHRRALLEHGACALHRHSFAPVRALKSREEALEAEMDAGEVLFDDGDLGGAVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2F2</accession>
    <name>E8X2F2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ordered locus">AciX9_2132</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580492.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2132"/>
    <dbReference type="EnsemblBacteria" id="ADW69176">
        <property type="protein sequence ID" value="ADW69176"/>
        <property type="gene ID" value="AciX9_2132"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2132"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_0"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW69176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="272" mass="30182" checksum="D2CA0910F6B17DC3" modified="2011-04-05" version="1">MRFDLVSIFPKFFDGPFEYGVVARAAKTGLVQVRTHDLREFTHDRHRTVDDRPFGGGEGMVLKPEPLFDCLAGMGLSEKKDRAAARETVVLLSAQGKPFTQAMAVELAGLERVVFVCGRYEGVDERINELLCDREISIGDYVLSGGELAAAVILDAVVRLLPGVLGNPDSAKFESFGVEDAGPGYVAGEVPPSTHGAGGLLDYPHYTRPAEFRGIGVPEVLLEGDHVKIRRWRRERALEKTWRNRPELLKSATLTKEDRRCLSDLERTKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I3</accession>
    <name>E8X2I3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_2163</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2163"/>
    <dbReference type="EnsemblBacteria" id="ADW69207">
        <property type="protein sequence ID" value="ADW69207"/>
        <property type="gene ID" value="AciX9_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2163"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_1_0"/>
    <dbReference type="OMA" id="PVDFQYH"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="566" mass="63262" checksum="6C3B7EAEB0C26968" modified="2011-04-05" version="1">MATTTSTPEYKQGKPELLQPGRGRLLVEYLHGWITTVDHKRIGIMYILSALLFLVIAGAEALVIRWQLAVPNNDLVSAANFNRLFTLHGTTMVFFVGMPILFGFGNYLIPLMIGARDMAFPRLNAFSFWVSLFGGLLLYFSVIGGSGLYGAGSAPDVGWFAYAPLTSRVFSPGHSTDYWTLAVMLSGIGSVGTALNIVTTTISMRCRGMKLMRMPLLVWLYFVTCLLVLVALSPLTAAQIMLCLDRYLGAHFFDTQAGGSAVLWMHFFWIFGHPEVYILVMPAFGFASEIIPVFSRKVIFGYPAMVLATISIGFISLSVWAHHMFTVGLGPGPNTFFTLATMIIAVPTGIKIFNWLATIWGGRVRFATPMMFSVGFLFNFLIAGLTGIVLSVSPFDWQLGNSYFVVAHFHFVLVGAILFMIFGAFYYWFPKMSGKMLSERLGKWHFWLFLFGFHMTFDLMHIPGILGMPRRIYTYQADRGWGTLNMLVSIGAIFQTIAVGIFVWNLIDSLRHGEPAGPDPWDACTLEWSTTSPPPAYNFNDEPEVHSRRPLWDLKHPDDPDTDYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2T3</accession>
    <name>E8X2T3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3372</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581692.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3372"/>
    <dbReference type="EnsemblBacteria" id="ADW70380">
        <property type="protein sequence ID" value="ADW70380"/>
        <property type="gene ID" value="AciX9_3372"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3372"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_0_0_0"/>
    <dbReference type="OMA" id="LYRKSTF"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="238"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="469" mass="50098" checksum="F4581664A30095F0" modified="2011-04-05" version="1">MPAVVHALDLRTLAQSVLDRALKAGATDAEAVAYEGEEFSALVRLGQVETLKESGSRAIGLRVFNGLRSASTSSSDLSPDGLAKLVEGAVALAKITSEDPFSGLPEASAFGQIETDQHLYYEDVNDQPPEERIEIARRCEAAAMAFDTRIQNSGGGDFDTATSHKIMVNSRGFIGETRRSYCGFSAAPIAHDEHGHMQRNYWFSSSRTTRLLEDPEAIGRKAAERTLRRLGARRVKTQRAPVVFSPEIAKSIIGNIFEAANGDAIYRHASFLDDMLGQQIAGPNINVIDDGTMVHKRIDPLTGDTILIGGFGTSPFDGEGLPTRRTVLVENGILKNYVLNTYTARKLGMASTGNASRGLAGNPGIGAGNFYLEPGTQTPEEIIAGIPSGLYVTETMGFGVNLVTGDYSQGAAGLWIENGELAYPVEEITIAGNLKDMYKNIVAIGNDLTFRGAAAAPTLHIEGMMIAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y0</accession>
    <name>E8X2Y0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Deoxyhypusine synthase-like protein</fullName>
            <ecNumber evidence="3">2.5.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1051</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579437.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1051"/>
    <dbReference type="EnsemblBacteria" id="ADW68114">
        <property type="protein sequence ID" value="ADW68114"/>
        <property type="gene ID" value="AciX9_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1051"/>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_0"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="OrthoDB" id="589228at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00640">
        <property type="entry name" value="DHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023496">
        <property type="entry name" value="Deoxyhypusine_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="355" mass="38742" checksum="6B55D1DF87303D1E" modified="2011-04-05" version="1">MPTKEELLKAPIQHVDIKQHNVVPLVEAMAHMAYSARDTARAADIYDMMLRDTDCGVILCLAGSLISAGLKTLFVDLIRNNMVDAIVSTGANIVDQDFFEALGYKHYIAGDEYKYGAGDADLRELMIDRIYDTFIDEAELRVCDDTIREITDSLTPRAYSSREFIQAMGKYLVDKGRTPAAGNDDSIILACYEKNIPIFVPAFSDCSAGFGLCAHQHARQGKPVVSIDSAKDFYEITKLKIANPVTGLFMVGGGTPKNFAQDIVVAAEILGDDAPMHKYAIQITVADARDGALSGSTLKEASSWGKVDLTYEQMVFSEATLALPLIAGYAFHKKGYLARQGKNFAEILDQVAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X334</accession>
    <name>E8X334_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2215</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2215"/>
    <dbReference type="EnsemblBacteria" id="ADW69258">
        <property type="protein sequence ID" value="ADW69258"/>
        <property type="gene ID" value="AciX9_2215"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2215"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_8_0_0"/>
    <dbReference type="OMA" id="MNRIGRE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022290">
        <property type="entry name" value="CHP03858_lucif-like_mOase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03858">
        <property type="entry name" value="LLM_2I7G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="356" mass="38620" checksum="4EFE94EFAF31146E" modified="2011-04-05" version="1">MEPRCWLGDNGWMTIQIGCDSFAAIGPDPVTGVARSGVERISDLLDEITLADEVGLDTFGLGEHHRAEYLDSAPVVLLAAAAARTKNIILTSAVTVLSAADPVRVFQEFATLDLISKGRAEMVVGRGSFIESFPLFGLELKDYDSLFAENLDLLMALRESTTVHWKGKHRAALTGQGVYPRPVQERIPIWLGVGGTPESFARAGMLGLPLMVAIIGGEPHRFRPLVDLYREAGKRAGHKPETLKVGVHALGYVAATDQQAADDFFPGYAEAFTKIGKERGWPPTTRRQFDALLGDTGALAVGGPERVASRVKYYDEVLGGISRFEFQMSVAALPHEKVLRAIRLLGETVRPTVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3B6</accession>
    <name>E8X3B6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YiaAB two helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581729.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3411"/>
    <dbReference type="EnsemblBacteria" id="ADW70417">
        <property type="protein sequence ID" value="ADW70417"/>
        <property type="gene ID" value="AciX9_3411"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3411"/>
    <dbReference type="eggNOG" id="COG4682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123353_0_0_0"/>
    <dbReference type="OMA" id="GFYAFAF"/>
    <dbReference type="OrthoDB" id="1733599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038972">
        <property type="entry name" value="YiaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008024">
        <property type="entry name" value="YiaAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37290">
        <property type="entry name" value="PTHR37290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05360">
        <property type="entry name" value="YiaAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="2">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="2">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="139" mass="15393" checksum="6FCC78F46575E19F" modified="2011-04-05" version="1">MATVYKKPTFAFIAASWTALFAGSLAFMVGLWNATMVLSEKSYFFTLLMYGLFSAVSVQKSVRDRMEGIPVTNIYYGLSWFSVLLTILLLAVGLWNATLTPSEKGFYAMSYLLSLFAAIAVQKNTRDNADLTTEHSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3E0</accession>
    <name>E8X3E0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3436</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70441">
        <property type="protein sequence ID" value="ADW70441"/>
        <property type="gene ID" value="AciX9_3436"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3436"/>
    <dbReference type="HOGENOM" id="CLU_2954056_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="59" mass="6634" checksum="3605A130FC26E8EE" modified="2011-04-05" version="1">MVADLSYEAPTAVSVGFGTFLGLEGRADLSFYLRDFLECRWQKSEKATSSAFFWLGNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F5</accession>
    <name>E8X3F5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ordered locus">AciX9_3451</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581767.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3451"/>
    <dbReference type="EnsemblBacteria" id="ADW70456">
        <property type="protein sequence ID" value="ADW70456"/>
        <property type="gene ID" value="AciX9_3451"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3451"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_0"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="38781" checksum="80496F6A1A7280DA" modified="2011-04-05" version="1">MPSGLILGIESSCDETAASVVKNGTQVLSNVVASQIALHAAYGGVVPELASREHLRNIVPVVRSAIAEAGIVFSDLDAIAVTEGPGLPGALLVGILYAKSLSFGLDKPLIAINHLEGHIHAVLMQSAPRTDGPLLALVVSGGHTHLYLATLTPSNTWTYRNVGKTVDDAAGEAYDKVAKLLGLGYPGGPWIDALAPFGNPAAISFRFGPIDTKEKDLRFNFSFSGIKTAVLRYIQAHAMQPEIEARRSALALTPDLPPKDAAALCNQQTLDLIASFQASVVGVLIRQTLAAAEAFGAKSIVVSGGVAANRELRERFHKESESRGLSVAFPSLALSTDNAAMIAAAAWPRLLANEVAPESMSAMPQLRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3F9</accession>
    <name>E8X3F9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3455</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581771.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70460">
        <property type="protein sequence ID" value="ADW70460"/>
        <property type="gene ID" value="AciX9_3455"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3455"/>
    <dbReference type="eggNOG" id="ENOG50340QS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115879_1_0_0"/>
    <dbReference type="OMA" id="IAPACPY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="16237" checksum="A970F14582D2179A" modified="2011-04-05" version="1">MKILRYLALLSIFVIPFGVAHAQIGIGIGIGGYYNAPSCSYGYYGYAPYSCAPYGYYGPSYFNDGIFIGAGPWFRGGYGYRGGYGYGGYGYRGGYGYRGGYGGYGRGGYGGGYRGGYGGGARGFAGGGGRGGFGGGGAARGGFGGGGGRGGGGGFHGGGGGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I7</accession>
    <name>E8X3I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579501.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1115"/>
    <dbReference type="EnsemblBacteria" id="ADW68178">
        <property type="protein sequence ID" value="ADW68178"/>
        <property type="gene ID" value="AciX9_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1115"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="YQFEVNL"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="266" mass="29238" checksum="72A0D6566BB4464E" modified="2011-04-05" version="1">MTKTILITGTSSGIGRATALYFAEQGWNVAATMRDPLKADPVLKHPQITLFAMDVTNADSIAQAIADTLDRYKKIDVLLNNAGYALFGPIEALASQQIQQQFATNLFGLIGVTQQVLPIMRQAGSGLIINISSIIGRLALPYASSYIATKFAVEGLSESMRYELEPFHIRVKLIEPGSISTEFGKGSMQMAVSAPYRKSMDKFLGVFNKSNAAGASPEQVAKVIYRAANDSSNRLRYLTKPGPFFWLNRILPDVLWRRLLMKAMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3U0</accession>
    <name>E8X3U0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580684.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2331"/>
    <dbReference type="EnsemblBacteria" id="ADW69368">
        <property type="protein sequence ID" value="ADW69368"/>
        <property type="gene ID" value="AciX9_2331"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2331"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_0"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="252" mass="27840" checksum="26DAF97C12AA5568" modified="2011-04-05" version="1">MVIINGEFVELETPSGPMRTHIVRPAAPGRYPAILFYSEIFQITAPIRRTAAMLAGHGYIVAMPEVYHEYEPAGSILAYDQAGSDRGNFLKTHKPVAAYDADTRAMIDHLVARPDCTGKIGAMGICMGGHLAFRAAFNPEIAGTVCFYATDIHTGTLGEGKHDDSFARAAEIKGELFMAWGRQDPHVSTEGRMKLLARLNELNTLLNWHEVNGAHAFLRDEGVRYDPEHAHAMMSLTYDFFHRKLGQGDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X401</accession>
    <name>E8X401_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3504"/>
    <dbReference type="EnsemblBacteria" id="ADW70509">
        <property type="protein sequence ID" value="ADW70509"/>
        <property type="gene ID" value="AciX9_3504"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3504"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500369_0_0_0"/>
    <dbReference type="OMA" id="DTANHPM"/>
    <dbReference type="OrthoDB" id="368810at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="536" mass="57778" checksum="7575451E0CB24FC1" modified="2011-04-05" version="1">MEKNSQAVFPNHQHSRGKAWRWTLWSVLLAAAVLIGVLQILVARAGPILKGRVVETLKTRFDSKVELDRLQVSILQGLNVTGGGLRIYPPDDVMAAGAKAPLISVDAFEFHAGLLGLVFKPMHVGAVHVRGLAIHIPPRKMRQQGAAKPRHLGKVKIEVDEIVCDDSQLVIGTDKPDKDPKLFELKHIVLRDVGPNAPWPYDAVLTNAVPKGDIHAAGSFGPWNTESPGDSSVMGDYRFDHADLNTIKGIGGILHSTGHFEGQLDRIAVQGTADVPDFSLDTANHPMYLKTEFSAVVDGTSGDTYLQPVQARLGESDFTCSGAVVNVKGKGHIIDLDVDVPAARIQDFLQLSVKTEPAVMSGVITTKTKLHIRPGPESVTQKLSLKGGFVLKRIHFTNPEVEDKVDMLSLRAEGNPKDAKPGAPDVHSLMTGQFEMSGGKLNFSNLNYTLPGASVALAGVYSLDGQQFEFTGKVRTQAKLSQMVASKWKSLLLKPVDPFFHKDGAGAVIPVKISGTKSAPKFGLNLGGKKPDQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X477</accession>
    <name>E8X477_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0046</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0046"/>
    <dbReference type="EnsemblBacteria" id="ADW67137">
        <property type="protein sequence ID" value="ADW67137"/>
        <property type="gene ID" value="AciX9_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0046"/>
    <dbReference type="HOGENOM" id="CLU_2193255_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="108" mass="12400" checksum="C6992961F49959B6" modified="2011-04-05" version="1">MRPRLHCSRLGLERKNAINCDGLTLLLAVSMTSTGTYNFDDNFTVFLDIFNNFNGQVFTVLQRKNAHRTYFGFVQPLRNFGTWHLPISIAVSTAMNRCQCLFQHSHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X479</accession>
    <name>E8X479_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0048</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0048"/>
    <dbReference type="EnsemblBacteria" id="ADW67139">
        <property type="protein sequence ID" value="ADW67139"/>
        <property type="gene ID" value="AciX9_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0048"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028597_0_0_0"/>
    <dbReference type="OMA" id="EPNIDFW"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230215" evidence="5">
        <location>
            <begin position="24"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="496" mass="55681" checksum="A3AE97CB0C060F71" modified="2011-04-05" version="1">MRQFWLKGLLLGAAACATGVGHAQETVVVDAHAAAKPFPHFWEQMFGSGRAILTLRESYRDDVKAVKKVADFKYVRFHAIFHDEVGVYNEDEHGNPVYNFAYVDAIYDGLLKNGVKPMVEISFMPKKLAFPDALHPFWYKQNVSPPKSMEKWDGLIHAFTQHLIDRYGVDEVASWYFEVWNEPNIDFWNGIPRLESYFELYDHTARDIKAVNPRLRVGGPATAAAQWVPEFLAHVAENHVPIDFVTTHGYGDDTVENMFNTHEKIAVDDRVGRAVAKVRGEINKSPLPKLPLYWTEWNVPGLMQSRDTTYVGPALANTVREADGNVDMLSFWTFSDVFEEGGPTTTPFRGDFGLRAFDGINKPSYYAYGLLHELGPQRIANKSDNVIVTKDADGGLALVAWNLVDPDQHGSDRTMELEFKGVAKDAKVTIERVDNEHGNVLPKWAAMGKPLNPTPTQATQLNEETAMPAPEQTTLVNGRLKLELEQNALVLVKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4B9</accession>
    <name>E8X4B9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_1183</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1183"/>
    <dbReference type="TCDB" id="9.B.142.9.5">
        <property type="family name" value="the integral membrane glycosyltransferase family 39 (gt39) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68246">
        <property type="protein sequence ID" value="ADW68246"/>
        <property type="gene ID" value="AciX9_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1183"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578618_0_0_0"/>
    <dbReference type="OMA" id="CPFTANY"/>
    <dbReference type="OrthoDB" id="890036at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="107"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW68246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="542" mass="61133" checksum="DF2B0FB548189B3A" modified="2011-04-05" version="1">MATKPALAAEGRFSVQTTCRTTYDAWTMTTSDATDGTKRRYLLLTIAALLAGLLLRLWFIHRFAQVANDTLLYGDFARNTLQHGIYGFSQTLNGHPAPPRPTLIRLPGYPAFLALCFLVFGYDHYLPVLILQTLIDLATCCLIAALAHRLVSRRAGLIALWLGCLCPFTANFVAIPLTETLTLFTIALAFYALHRWQSYIFGQFSPIKKGVVILSEAQNLSILSGAPHAVTETQSPYRPFNPWLYLLAATLAYSILLRPEQGILAAAIIPAILYITWRTQPTSKFTLRTLRPAVIASLLTILPLIPWTIRNERTFHVFEPLAPRFATDPGELITLGFQRWYRTWAIDFASTETTYWNLGSDTLQIADLPNRAFDNNTQYATTEALYAEYNLTTTPTKSLDDRFATLAATRVRSNPIRFYLALPIARLINMAFRPRIDFLPLPLEWWKFRLHPRSTLFSYAYGALNLAYFALAAAAFTRRRTLFPNWPIPAPILWSMAGMILLRAALLLTIDNSEPRYTLEFFPILILLAASFTSAAHDRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4F0</accession>
    <name>E8X4F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1214</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68277">
        <property type="protein sequence ID" value="ADW68277"/>
        <property type="gene ID" value="AciX9_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1214"/>
    <dbReference type="HOGENOM" id="CLU_3216873_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="44" mass="4769" checksum="C36D21D3DD497E9F" modified="2011-04-05" version="1">MDRSWVPHVPILGRGFPPTPPGPLYFLVDVFFLAVPAAFATLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4G9</accession>
    <name>E8X4G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1233</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1233"/>
    <dbReference type="EnsemblBacteria" id="ADW68296">
        <property type="protein sequence ID" value="ADW68296"/>
        <property type="gene ID" value="AciX9_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1233"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="IATNTMF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="319"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="44597" checksum="52B5AA954F900DC6" modified="2011-04-05" version="1">MLSLSDILRQIFQSIWANRLRSFLTMFGIAWGVASLLLLIGLGEGFRSGQTRSLKELGSDVIFLEGGNVPAVPNQHTGMRAYKVTLSDEKAIMEQAPHVRNATAVVSRGDLKQVSEFSSAGGQALGVEANYPEIRNLPLAKGRLLDAEDVATARRVVVLGKKNAELLFPEDRPAVGAYITINGERFLVVGVAAGISRGNNDGDNQKVYVPISVMLQSFPLKGENIPADSVSSIQYQPATEELNETAKTEVHRVIGARHGFDPLSKDAFEEWDTIKNNKMVGVIFTAMDLFLGAVGIVTLALGAVGIVNIMLVMVSERTKEIGLRKALGATNKSVMAMFFLEGLLLTGVSGAVGIVGAGTLMSVLTAVAGTNTNGFDPPRLVPWSVALAVGTLTISGCLAGLVPARRAAMLEPVEALRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4L3</accession>
    <name>E8X4L3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="11" type="ordered locus">AciX9_2386</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580739.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2386"/>
    <dbReference type="EnsemblBacteria" id="ADW69423">
        <property type="protein sequence ID" value="ADW69423"/>
        <property type="gene ID" value="AciX9_2386"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2386"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_0"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="254"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW69423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="662" mass="76007" checksum="34E2501AC1AD12D2" modified="2011-04-05" version="1">MDLLQKIRTLPTSPGCYLYKNAEGEVIYVGKAKNLRSRVRSYFLEANQRNNQKTGSLMREAVDVDYITVDNEREALALENNLIKQRKPRFNILLRDDKTYPYIKITLTDRHPKVFVTRRLRKDGGAYFGPYFPGNLAHRLVDLIHRSFLIPSCKVDLNRYHPRACLQYYIKRCLGPCVEGLVTPETYKDTIRDVQLFLDGRTDELEKRLTARMAEAAENMQFELAARLRDQLVTVSQMQDKQRIATTDNEDADVFGFHYENQMLAVNLFHMRGGKIVDRRDFFWEDLPDLAGHFGESLNEGEETEAALEPDTRRSAPEIEEDSTSVQQTPVAELGAVFSPAAFFSALLKQLYLDQSYVPRSIYVPVDFPDRVLLADLLSERAHHRIELAAPQRGDKRSLVDLVCQNAKQSYDQRFRVLQPTKKLIADTLQDILNLPETPKRIECFDISHIQGSETVASMVVWEDGVMKKSDYRKFQIKTVSGNDDFASMREVIQRRYKRLLDEKKPFPSVILIDGGLGQLSAAYAALEEIGVTLQPLASIAKKEEIIYVHGQEDEPVVLDRRSPVLHMVQKIRDESHRFAVGYHRKRRQIRDRETELDPIPGVGPRTRQRLIEHFGSIRAIKQTAEQNPDALTAVVNQATAEKIRRYFFPTPAEPETLVQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R1</accession>
    <name>E8X4R1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3546</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581861.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3546"/>
    <dbReference type="EnsemblBacteria" id="ADW70550">
        <property type="protein sequence ID" value="ADW70550"/>
        <property type="gene ID" value="AciX9_3546"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3546"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="MGADKML"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="21055" checksum="4254308572BDFCD7" modified="2011-04-05" version="1">MPKRRVLLVDDEIAVLLTLKAVLEISGFDVDTAASAREAKSKLKSKQYEMVITDMRMESEVAGREVIVAARTADYHPAVALLTAFPVADEDWQDMGADKMLVKPMQTRSLIQSIEKLLESHQAKLKKLEKGGAAATLAAGFAAGMAAAKTTTPSPAPKKAAKAPAKSATVKKTATAKKTAKKATAVKAPAKKKAVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4T2</accession>
    <name>E8X4T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581882.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3567"/>
    <dbReference type="EnsemblBacteria" id="ADW70571">
        <property type="protein sequence ID" value="ADW70571"/>
        <property type="gene ID" value="AciX9_3567"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3567"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_10_0_0"/>
    <dbReference type="OMA" id="TNYRKRA"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="96" mass="11295" checksum="48BE4A8D9F6386B3" modified="2011-04-05" version="1">MSYSVVFSPRAKRQLERLEDYLAERFYPANAERYIHRLTRACHSLALMPFKGTKRDDLRPGIRTIGFERRVTIYFAVESDQVQIISILYGGRSEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4X5</accession>
    <name>E8X4X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase subunit III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0076</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0076"/>
    <dbReference type="EnsemblBacteria" id="ADW67167">
        <property type="protein sequence ID" value="ADW67167"/>
        <property type="gene ID" value="AciX9_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0076"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_1_0_0"/>
    <dbReference type="OMA" id="AFWHMCD"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="40"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="29506" checksum="88D5D43DC8778678" modified="2011-04-05" version="1">MANTVEDVHGHAGLETDHGHHDHVALPQHRHHFETEEQQREAVSFGMWLFLLTEIMFFGGMFFAYLLYRNWYYDAFVAASNTLVIGWGALNTVILISSGFCMAVGVWAAEVRNQKILVLMLWLTTIFGIAFLGVKGIEYTAKFKDHHVPGASFNVKEFVNPPIDANTGKPTENPLPPDMAQKTQIYFFLYFAMTGMHAVHMIIGIVILFWLIARANKGEFSTGYVAPIENFGLYWHFVDIVWLFLFPLLYLINRHPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X578</accession>
    <name>E8X578_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1280"/>
    <dbReference type="EnsemblBacteria" id="ADW68342">
        <property type="protein sequence ID" value="ADW68342"/>
        <property type="gene ID" value="AciX9_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1280"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_0"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="276" mass="28935" checksum="4C114577CC53FD45" modified="2011-04-05" version="1">MSAGHGVPQGPQPLPGVSHVVAVGSGKGGVGKTTVAVNLAVALGRMGYRVGLVDADIYGPNVPTMLGVTRQPNVIGENRIEPILSHGVKFISVGLISPGDKPMMMRGPMLHQIIRQFLMQVEWGDLDFLLIDLPPGTGDVVISLVQTVPLTGAVVVSTGSSVALEDARKALEMFHQVKVEVLGLVENMSQMRMPDGSMLDVFGAGGTERTAQQFGLEFLGSVDMNPAVRKGGDTGMPVALAGPDSELGRNFYDVAKKVVDAAERVADAEGDVLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B9</accession>
    <name>E8X5B9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2430</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580782.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2430"/>
    <dbReference type="EnsemblBacteria" id="ADW69466">
        <property type="protein sequence ID" value="ADW69466"/>
        <property type="gene ID" value="AciX9_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2430"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442734_0_0_0"/>
    <dbReference type="OMA" id="MRIGERY"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234398" evidence="3">
        <location>
            <begin position="36"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="635" mass="67672" checksum="E24956B0638FB8CE" modified="2011-04-05" version="1">MKQPAHSRSDFATRRRSVCLTVIAAAALASTSAFSQAPSVKPDPRKAEQAYLAGAILIDHRDFAAAQSQFAKAVQLNPTRQDYTLALAVARESRVSNLIQQAAKARMDNQADRSDRLLAEARAVDPGSDLVLQRIQAPQQPMTHVEPAQSKDMLFAPPLQIAAAAGVHDLHLRGDVKQVLSQVASTYGIKAVYDADLVSQQIRFDLDAVTYTQAMPILLRMAHLFAVPIDSKTLFVVKDSQEARQKYERQAEETIFVPGSTQEQLNELVNIIKNVFDVKQIAIQQNSSSLVVRAPEPTLKAVNYTIADLVDGNAQVVMELKLYTVDKTRTRNLGLTTPNSVGGFSVAAEAQGIVSANQSVIQQAISQGLFTPSGNAATDTITEAIYLIASGLATDAKLSGLLTLVGGGLTTAGIYVGSNPTLNFALDTSDTRALDDITVRSGDRQTTTLKVGSKYPITTSTYSSGVSAATSSALAGVTVGGVSASSLLNQYLGASSQTIPQIQYEDIGITLKTTPTVLKSGLITMHIDLKIEALTGQSANNIPVLTSRVFTSDVTCPEGSTAMMLSQLSSQESAAVSGIPGLAELPGFQTSVADRITERDSSELVMMVTPHLVRRRSNTLAGPRIAFQTSVPQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D2</accession>
    <name>E8X5D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580795.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2444"/>
    <dbReference type="EnsemblBacteria" id="ADW69479">
        <property type="protein sequence ID" value="ADW69479"/>
        <property type="gene ID" value="AciX9_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2444"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381220_0_0_0"/>
    <dbReference type="OrthoDB" id="956301at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="304"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="528"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="762" mass="85289" checksum="1AA744D3E2100944" modified="2011-04-05" version="1">MPEPVEVIIGIRVFEEPQRLHATLQALAAHTAVPHRLLLLGDGPDAETSAALSTLADIEQSSTTEHLGGASCFNRLTMYPAARAYVLLESGARPGPDWLDRLLATMMRTPGCGIAGPSTNRSSNQQCLFPGRGTEANEQPPDDIAMARLAARRFGHLARPLVPRLDLADFCYVVSRETVDGVGPADESYGPGPCWEMDYNIRAYRAGITALWVCAAWVGRAPVGKREAEDHAILGVRNRQRYADTFCLKVAHKATSYPSPVVSPRMPLQQLRPLPLPDLSLPAPQKFPREPRRYTPIEGSPLASCIMPTAERRAFVPRAIAHFLAQDYAPRELIVIDDGTDSIRDLIPNDERIRYVRLSAKSTIGAKRNHACRLAAGPYILHWDDDDWYPSDRIRRQVAALQLPDVEACGSSELYYFEPKTEMAYRYHYRGGDSPVWFGGLAYLRSAWERHPFDDLQMGEDVRFLGHIAPAHRHDLHDPALIVATLHPGNTSPKHLNNPCWLREDAQRLTAWMAEHERRMLTPHVRCIMPTRNRRAFIPLALACFQTQEWPNKELVIVDDGEQAVEDLVARVENVRYLRLDCRHSIGEKRNLACAHSSGSYIVHWDDDDWHAPNRISRQVEPLMNGAHDLSGLNMQFLLEVQAGAFWQISGQLHGRMFVGDVLGGTLTFARKVWLDGARYPDTNLAEDAGLIRNAQAMGKQLLRLENGGEYIYMRHPGNTWQFEPGGFIDPGGWRRGEAPAGFSPALLQRYRAASRQVALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5F9</accession>
    <name>E8X5F9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2473</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580822.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2473"/>
    <dbReference type="EnsemblBacteria" id="ADW69506">
        <property type="protein sequence ID" value="ADW69506"/>
        <property type="gene ID" value="AciX9_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2473"/>
    <dbReference type="eggNOG" id="ENOG5031GK0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022847_0_0_0"/>
    <dbReference type="OrthoDB" id="1670794at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027612">
        <property type="entry name" value="Put_MTase_LIC12133"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04325">
        <property type="entry name" value="MTase_LIC12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="280" mass="30740" checksum="A8ED7A7CBD537CCE" modified="2011-04-05" version="1">MAPQQGLLRRVRQMQAKAVSRVMLRVAGNGLGRRVVQGLGRSRVVERVMVGYRRGFSSMAEAEACAARLGVGGHTHPDAIRQHLELGESMRPSDGPAVEHLRRLLPEIGRVADVGGSAGNLFYLYSGQVEFPEGLVWTVYDLPETVKVGRSLAFDRRVTGLEFCTDLFGPVEADLMLLSGSLHFLEALPPEIMGGWKRRPKYVLVNRSPVSEEGGVYGLQDQWTWMTAAKVLNRGDLVGGMGAAGYELVDEWGAAELRLMLPMRPQSSAAGYSGFLFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5Y4</accession>
    <name>E8X5Y4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4086</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572780.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70868">
        <property type="protein sequence ID" value="ADW70868"/>
        <property type="gene ID" value="AciX9_4086"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4086"/>
    <dbReference type="HOGENOM" id="CLU_1353045_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230763" evidence="1">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="202" mass="21464" checksum="1F9EB2826662D214" modified="2011-04-05" version="1">MIHLCLACPLLTLQILCSPALHAQKQAVTPHAILQQKTPLPAFTLWTAEGATVDNTHVNPGGYWLLLYRDLDSTAADQALQLLESLTTPSTLVGPNGALPPLPLDPARLIILVTHATGAQLSQLQLAHSALATAIWMRDQNSSAAAALNIAGFPQLLGLHENARRWQLAGSLEQPTTRAAILSWINNNALPKTSSPSSSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X604</accession>
    <name>E8X604_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4108</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572800.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70888">
        <property type="protein sequence ID" value="ADW70888"/>
        <property type="gene ID" value="AciX9_4108"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4108"/>
    <dbReference type="HOGENOM" id="CLU_000445_28_2_0"/>
    <dbReference type="OMA" id="LWQRWEF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="896"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111685" checksum="0B279D1A32836163" modified="2011-04-05" version="1">MKTSSSGPSRRTALHVLRCLLLFALILLLHGVARAVDGTRPMAQYLLQQWGAEQGLAVGHVNAIAQTPVGYLWIGTDRGLMRFNGLRFVPKQPPSPEYSPIERVISLAVDVDGALWIRAENARLLRYFDGRFTLGFPVNQGETSLTAIAPGHRGGLLATGLKIGGMQVTTGGVTRLRPSVGSLLISVAQTTDDTVWLGTREIGLFRWKDGTLQPAVTGVPDRKINCLLPTPDGHLWIGTDNGLGLWNGQTVVTVPFPAEFDHLQILAMVQDRDHNLWLGTSKGLLRYNTAGMAWLQRNARERDQAVTALMEDREGDLWFGNGGSLERLRDSPLITYGDAEQPSGEQFGPTYVDAHGRVWLAPITGGLFWMRDDAIHAVTADGLNQDIVYSIDGSGDNLWLGRQQGGLTRLHSSGDTFTAQTWTHADGLAEDSVFSVRASRDGSVWAGTLTRGASHLVNGKIEARTDGNVLSSETISAIEEDRSGAMWFASPAGVNVLRGTSWRSLGVKDGLPSQQVFSLLADSAGAMWVGTSDGLAYVDKGHVHSFSGSPLGKEPVLGMGVDQRGLLWIATALHIFSAPRAALLAGNLNPETIRSYSVQDGLRSTEGVRRFRSVVNDGLGRVWISTGRGLSVTSSGVGEHLLPAIPHVEEIISDGVAVNLMGDVRVSPNTQRIVFQFSGLDLRAPERVRFRYRLDGFDKAWSEVVESLEAVYTNLPPGRYRFRVVAANSEGRWNAQEGMLSFRVEPMLWQRWEFQLLCLCTLTLISIWIYRRRMQFLITQANMRFDERLVERTRIARELHDTLLQGFISASLHLHVTAEALPSESPVQRSLQRVLLIMERVIEEARQAVKGLRTFDGSSTPRLEQIFRELVLEVDEAEATGYVVVVEGEYRTLRPAIYEEVSRIGREAVINAWRHADAEHVTVRLEYMSGRLGLEVTDDGTGMDVATVSHGREGHWGLLGMRERAERMGARLQIISRLGQGTRIVLNVPAGIAYPDEPWGGRTKEADRFRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X674</accession>
    <name>E8X674_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor, plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4179</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572870.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70958">
        <property type="protein sequence ID" value="ADW70958"/>
        <property type="gene ID" value="AciX9_4179"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4179"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="SSRWQMQ"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233729" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1100" mass="118049" checksum="EABF0B496F47D5C5" modified="2011-04-05" version="1">MLSHFKRNAIVASIAVFSAGAPMLAQTFHGTVSGTVSDSSGAVITGANVQLVNPATGVILNATSSKAGEFNFQELPVGTYTLSISMSGFQSRKIEAIDVAVTKIENFPVVLSPGSASTEIEVTASGVQVDTQSSALVAVIDSKAVEDMPLNGRDFTRLTHFAPGVAAISNSVNGSRTASINFQLDGADNVDPWLGIVASNQGGIASVPGGLIPIEAIDQFSMQSGGEADQGRNAGANSNMVIKSGTNHIHGDVFYFDRNEFFAALSPVAGAGTRKTLIRNHQGGFTLGGPIWKDHTFLFTAGEIQIAKANVALSDTVVSDAWITAATANIAAFNKAGAIDPITKQPYAVSALSTNLYNLLYPANSKGSAATTNNYFASGTSNYNSYNGIVKLDHHFSDKQSLSLRYLGTTGTQTAPTASDYAQYFQTAPMHIHNFGIIHSYIFSPRLLNTVTFATNYFLQTFNDADQNFHPQANAGLNLGITNAIIAAGAPSILITGFDQTGATQPSGRTDVTGHVTDNFHWTLGKHELKFGGEYRHSNVNQLYFSSARGTFTFDGSRGPWSSSAGTQLADLSDFLIGAPTASSGARLLQGNAQRVWTYNTEDFWVQDDFQATKKLSLNYGIRYTVPGVIQAAANDIYQFVPGTTPGFQKGYYPEYYSGVAPRIGFSYAPFADERTVIRGSYGIFYDFPAMSSWITGTTTNGGAAYAQNNPAGPDAAVIFNQSGFEWAQNVNPFVGAAAPQVGAFGVNQNFKMPRATVVSFNVEQQLSKSTLFSVGYVGSFGSHLENLYNINQPVANGTKVANTNRPYDATTVYPNENPTFQGQKLLAINQLNFEAASNFHSLQTTVKQALWKGITATLNYTWSKSMDDASSSTTPMNSYNLHQDYGQSTFDNRNVVNGFVIYSIPQFGHFMPKLTKGYQVNALYTYSSGNPISPQYSTNVDGTGELKDRPNYTGVSPFTGVQLATSTSSQRTYRYLQNLVSNPSFTCPGAVSTSTTNPAVCPTTVTGVYGNEKRDNFTGPNFRTVDFSLIKHTPVTEKVMSEFRVEIFNIFNFNNFAPPTVTATSSSFGIISNTRNGAASPGIGFGEPFNIQFALKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X687</accession>
    <name>E8X687_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4192</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70971">
        <property type="protein sequence ID" value="ADW70971"/>
        <property type="gene ID" value="AciX9_4192"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4192"/>
    <dbReference type="HOGENOM" id="CLU_533089_0_0_0"/>
    <dbReference type="OMA" id="EVGLMEW"/>
    <dbReference type="OrthoDB" id="1083589at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018777">
        <property type="entry name" value="Replication_initiator_prot_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10134">
        <property type="entry name" value="RPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="58887" checksum="959FF67AAB865A72" modified="2011-04-05" version="1">MAKKASSQAATQTAIAVPDAIDLIRFEKNLLQIGFFSAHDRRSAAPDLSRRIEQWVNRDGKKIRASAEFRSSLGLPSTADRDKYMAFMKIAMERKLREGEITNPIRFSGYSMLKALGLSDSGANYEDLNQWGMRMADTTITSEQIIYSSSRRQFMNKTVHVFRSFTRVGESDLNGSHQTVQFAVELEDWLLENLNQSYVVPEDFTQYRKLVRPTAKGIFVYLYVWFYASHGKDVEKDYAELCALLNVRAYQHVSKIRETMGLSLDDLVGIGYLRKWDIAPMSSKKGFKLILTPGRAILDVIASTQRRQLTHPANGAAPILQLTNEQSEISAALIARGINPEKARSLAQGRELAAVQEQLEYLDSEISRDLSRNGSRRIKNPAGFMIAFLESGQPIPTTFPSAIKRSEAKSRTNGTVKHREAQAAEDLAEMHLRDRYKSWCLDQATEAIESRFTPDELQDQFKTLRTRLAKDPQIAASLTRMTQDQRRRELLKALQKEVIAELDLASYEEWSLANGQGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X688</accession>
    <name>E8X688_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572884.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70972">
        <property type="protein sequence ID" value="ADW70972"/>
        <property type="gene ID" value="AciX9_4193"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4193"/>
    <dbReference type="HOGENOM" id="CLU_1978403_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="14032" checksum="CC70E10DC5965DFE" modified="2011-04-05" version="1">MSNFLDLEENKEEEPIKPSANLRELLASVPKSTPRPHLNPEVSDKLAAQHGFSSRDHSSRDLTPAPTPAPIPAPILGRRTPRGAPIEETRQLSIRMPISLYADFLAFADAAHLTYSEAIRELLDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6B6</accession>
    <name>E8X6B6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha,alpha-trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4223</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572912.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71000">
        <property type="protein sequence ID" value="ADW71000"/>
        <property type="gene ID" value="AciX9_4223"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4223"/>
    <dbReference type="HOGENOM" id="CLU_006451_3_3_0"/>
    <dbReference type="OMA" id="TNGVLIW"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234438" evidence="4">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="537" mass="59805" checksum="685C3EFE8F2EF4B9" modified="2011-04-05" version="1">MPKLFLATILLTTSAIAQATLQPAPAPPSTDIHAYIANGWQTLSRSMVECKSVVDPKVTTTPILYLPAGLPTPPEVTAMQQQCHVEVRSLPHKIKDLGDLRPSELPKEGLLYLPKKYVVPGGRFNEMYGWDSYFILLGLVHDKQLDLARGMVENFFFEIENYGAILNANRTYFFTRSQPPFLSSMIREVYEAPGAPQDPKWLAHAYDMARRDYALWTSPAHQAGSTGLAAYHDLGEGPVPEMADDSAYYPDVIRYLEAHPDSDQQYLVPDSSDPATVARTSCDTQMSKVCAAAVVDGHRLSAAYFRGDRAMRESGFDTTFRFGTFSGSTDHYAPVCLNALLFKYEQDMAHLATLLHRPAEAASWKARAEIRHQAIDKFLWNPAAGMYFDYDFVDQHRSTYHYVTTFYPLWAGLASQVQATAVRSHLAYFERPGGLALSDVTSGVQWDQPYGWAPTTWLAVSGLEKAGFHEDATRIAKSFSATVEDNFKRDGTIREKYNVVSGSANVQVATGYKSNVVGFGWTNGVYLKLQDLIQPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C1</accession>
    <name>E8X6C1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_4228</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
            <plasmid evidence="11">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572917.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71005">
        <property type="protein sequence ID" value="ADW71005"/>
        <property type="gene ID" value="AciX9_4228"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4228"/>
    <dbReference type="HOGENOM" id="CLU_004005_0_0_0"/>
    <dbReference type="OMA" id="SYGICEP"/>
    <dbReference type="OrthoDB" id="1281138at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234439" evidence="8">
        <location>
            <begin position="35"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1218"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1245"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="248"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW71005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1308" mass="132583" checksum="40837E3B9E4A6A39" modified="2011-04-05" version="1">MIRSSFEVSTIGMRRIARAMMAAALLALPAVSLAQTAVRNLVTSPVDNAIRSTLHGSTPPLVRLSQDHGALPDSTPANRMLLVLKRSELQQAQLDQALADLQNPHTASYHHWLTPDTFATRFGPTDADITAANTWLTSQGFAINKLSKGHTAIEFSGTVAQVRNAFGTQLHSYTAPDGRAFHANNTDPQIPAALAPVVAGVAALNNIPAQAYSHVVGQARFDAKTHAATPINSANWTYPVSTGGVYLVTAPGDLALQYDINPLYTAGNKGDGEIIGIVSQAGVDNTMVANYRKLFGLSTTNLPTEIVDGFDPGINGDGAGIEANLDVDVAGSTAPNASLYVYTGYDTLVSLGLFNAAIRAVDDNRADVIGMSYGICEPTLGLAGNLLFNQLWAQAAAQGQTVIVSSGDSGGAGCDNGQSSGLHGLSVNGITSTPYNLSMGGTDFYYAAYGSSGLAATVNSYWNKTASPSPSTSILKVIPEQPWNDAFGLNAGGPPTTGTIAAGSGGPSSCVSGVSAPPTVGSSVDSFISCAAGTPKPSWQSAPGVPTDGVRDIPDISLFAANGANYSFYPICAVAGDCLASTVDPTTGAMQITGVGGTSASTPLMAGIMALIDQSLKGRQGNINYVLYSLANSTPAVFHDITVGSNNVNCTQGTANCALDKNGFYSYSNYAAGKGYDLASGLGSIDVNALLTNWSKATFATTTTSLSASSMSFTHGSPTILTSVVSSTTGTPTGVVSLVATSTASPQTGFGTMGLSNGTAQSTLTSLPAGTYQLLAQYGGDATYGPSISDPVTMTVTPENTSLAVSGLYYGVTSTGDTGPILPISNNMTSLYGSFFFIDVKLFGSSSTAAAPGGLPSGIVTVLDNGKTVTTLPTSTSGLVELQTGSLAVGTHALTFAYSGDGSFNAATSTPFNIIITPGVPQISFAYSVPAGMPIGAILNVPVEVSSSAGQLPLTGSLTITFGSQTRTISNLQQSSFGGLSSIGYGTVTFDTSTAGTFTLDASYSGDSNLAPVAHAYNPTSVTILKSALTPTITTLTMSASTIGPNQTINAIVKVTGGATAPTGYLALFQNSNFQTILVPLDATGSAVIPVKDTAILGNGNVQFLASYGGDSYNSASISNVQVVAANTGEFSLTVSQPAVSMSAGTTATSMVAVGAPYGLRLSGTVALSCAVSSPALACSLSSSSLTLPTDGVSVANSTLTITSQAGTVAALQPHPGLPLSILGGSGTLLALCMIVLPSAQRKKLPAILAIFLLAAALWPTAGCATTTTTTNQPPVNTASSNAGTYTATVTSTSAGITKTLLVKVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G9</accession>
    <name>E8X6G9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4283</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572963.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71053">
        <property type="protein sequence ID" value="ADW71053"/>
        <property type="gene ID" value="AciX9_4283"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4283"/>
    <dbReference type="HOGENOM" id="CLU_2716765_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="72" mass="7537" checksum="B58B2C490353E3E2" modified="2011-04-05" version="1">MRTLGDNSLSVVLELAQAAIATINTFFGALVSSAVIHPPAAMRCRFDRSTTAPNSMHQDLAQVAVAALADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Q9</accession>
    <name>E8X6Q9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3933</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582227.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71209">
        <property type="protein sequence ID" value="ADW71209"/>
        <property type="gene ID" value="AciX9_3933"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3933"/>
    <dbReference type="HOGENOM" id="CLU_045498_5_2_0"/>
    <dbReference type="OMA" id="SHEAVMH"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="278" mass="28547" checksum="6DAD54F373047F4D" modified="2011-04-05" version="1">MTLFVFTGIVLLSSIGAGLVGALTGLGGGIVVTPVLTLMLGVDIGYAIGASLISVIATSSGAAAAYVRDGLSNVRVGIFLEVATTLGAISGALISGKIPTTYLAILFGLVLLHSAWQASQARVEGGVVADQGSLSRRLRLGGTYRAEGKEVEYVVSREGTGLSLMYVAGMLSGLLGIGSGALKVIAMDRVMGLPFKVSTATSSFMIGVTAVASATIYFKRGYILPQMAVPVMIGVLIGSMVGARLLPRLPVKTLRRIFAIVVGMIAIQMIVKGVRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R5</accession>
    <name>E8X6R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna protein B-type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582233.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71215">
        <property type="protein sequence ID" value="ADW71215"/>
        <property type="gene ID" value="AciX9_3939"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3939"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="RKTFFFA"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234258" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1130" mass="120473" checksum="690EC5EE14BDC66A" modified="2011-04-05" version="1">MSLRASRLALLPVSFLTLAMIAGSALGQLSTTATISGTVTDATGAVVPDADILITSTDTRVTTSRKSTSDGTFVVPGLTVGTYSITVTKTGFGNYTATGIILHPAVTSTVNAGLTVGSTNTSVEVSAVASLVETSTAENSNSVDAAQVNTLPINGRNYQGLATMMPGAQNTSAGTALTTGGRSTNNVLSVNGMQQNKTFYALDGVWNENTGNMNQTSVVPNPDSLGEVRVLQNNYSARYSLMGSSVVLLSTKSGTRDFHGTAWEFIRNEDLNAKPFFSTAILPYKQNIFGYNIGGPVFIPKVYNRDRNKTFFFFSEQFVILHQTPTGAITGITPTDNQRAGIFGTPITNPATGKLFPQNTAGQYVIPAATINTNSTAFVNALYPHANYSSGSLNYINTVPQVTNQRDDEIKIDHDFSSKFHLLAEYLDEYQKYQQNSLSGAQSGEVYSTNGETDFTHNKLAQVSLSQVLTPNLVNTTNVAMNIFDLDLNLTGTALNTQVPGFNPSLPFAGYISNRIPLVTFSGGIGPEGIPAARPLTHAADLDDTVGDDVSYLHGRHFIQGGVTIVFNTKRQNVSSATNGQFTFTGSTTTPTKATDATTTQKAQATTLDDAFADFLLGSAATFTQTSGQPRVAVHGMEVSPYLEDRFKLTKTVTVTAGLRGYYMPLPYGPPKFETNFIPTSYSLAAAPTVAASGAITNSAASSANPLNGLVTNGPGTGVPQNFSGAHTWYAGPVFGLAWDVFGDGKTSFKGGYGITFTRVFTNQDCSFACAVNPPAIQSVSLVNPTFPAVVGTGAVRPATIAAVSAADQNIQATQVQSYSAGVQHEFPHNFIASATGASSQVRHLLGTWNYNQSLHTGVYDFDPSINSGSVSPYYYQPAGFATPAQFSPYPGYAAITTYTSRQNQNWNALELSLKHPVTKGLFATVAYTYSHDLSTFTSGTYSVVDPYNPSRYYGNAEGLDCRHSMGITLIYDLPIFENSSGLSHKLLGGWKFSDITTLRSGTALTPGLSVATQGNAVRPDKVVGTSIVGPHIKAQWFNTAAYVRPANGFYGNAATGSVRGPGLVDFDMALYKEFHYNETTYFEFRAESFNTFNHTNFTTINTTFGASAFGQATNAADPRILEFAGRVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X713</accession>
    <name>E8X713_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582144.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71122">
        <property type="protein sequence ID" value="ADW71122"/>
        <property type="gene ID" value="AciX9_3836"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3836"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="GANSCNC"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234268" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1231" mass="130563" checksum="05970CE17BA65921" modified="2011-04-05" version="1">MKTRRPSRSLSLVATTACFSLATFAAQAQIAGTGGISGTVQDKDGALIPGAKITVRENATGVSTVRQSTGSGYYVISPLIPGVYTVTVEAPGFQVFRQENLTVDALATVGLNPKLTVGAQSETITVSTAPAALQTTNATLGGVIENATYSELPLQITSGGPRDPTSFVTLLPGVNSGGRAGIFDGSGSGNSNEMYIEGVPQTTVDSQGDNRKLNQNLAIEAVDQFQVQTSGSSAQYQGLGVENYSIKQGTNTFHGNANFYIRNTAFDTWGYFQPWVPIVRADGTTGLPTKKNPEHQDELSLSLGGPILKDKLFFFANYDRYHYNGITNPTYQTIPTVDARNGDFTAYAAANPGYDIYDPTTVTACTTANKGVTCAYPFMGVKNGVPTKDVIPTAEISPIAKAMQSYLPPVANGNLTSNYLAGRVTGLQVWGFTGRVDYDLSPRQQLAFISTSGVKHIPPYDYGATSVLPYPYTNGTIVTETTTTDIVKHTYTFSPHAVNQLRYGFTRFSAPIGNATDGGSVTASTLGIGNLPAGLASSTFPGASFAGGVDAPSGFSAPTAYHEGVNTLTFGDEFVLTKGRHSITFGGTYQWLEFNQSISDSSSKPLSFAFNASSTAGYNSGSINTKSGLAYASFLLGAVDSSSIYFQNFSTLGARYRAFSPYVQDDYKVTKNLTLNLGLRWDLYTPFHEKNDRWSGFSPTQINPATGTPGALFYYGNGSGTCNCRTTVNTWYKNIGPRLGFAYQAASRTVIRGAFAIMYTHSGGVGGSNAGNYNGTGQLGLTAQQSFVDSGQGGQPAFYLNSNLGALSNTSIPNYSLTISPTAIANTGNYLVNGVSPTASSVSYADPYLSGRAPYTVSFNFGIQQALTRTLTLSADFAGNQSHFLVANSRGFYQDQLAPQYQALGALLKQLPGGMDKATGKTYLQEAQAIIPGIGLPYTTFGGSAATISQMLKPFPQYSSVTDTWGDIGNANYNALQISLQERKWHGLDLALNYTYSKTIDDISGVRSGYPIPNNVIDGGFGSTQANRIDRAVSANNVPNNLRIFGVYQLPFGDKSQFGGSHAAVRAIIGGWKVSYIYTKISGAPLSITGTSCQTPGSCYPSFNPAFSGSPRIGGGYGHGLTATTASTVKFLDATAFIATPGNNGYNFGNVQRSAPLNLYNLGNANLDAGLKREFPLFERFKLTMQADVINVTNHTQFGGLGTALASGAFGTFSKQNNGSRDIQLAARINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X733</accession>
    <name>E8X733_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4308</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71267">
        <property type="protein sequence ID" value="ADW71267"/>
        <property type="gene ID" value="AciX9_4308"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4308"/>
    <dbReference type="HOGENOM" id="CLU_3403799_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="30" mass="3106" checksum="0CF3A3F35219F4C1" modified="2011-04-05" version="1">MHLIAAATVFVVLSLVGVEFSIAAFVDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X775</accession>
    <name>E8X775_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4357</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71309">
        <property type="protein sequence ID" value="ADW71309"/>
        <property type="gene ID" value="AciX9_4357"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4357"/>
    <dbReference type="HOGENOM" id="CLU_2105525_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="12925" checksum="BCBE4635DD452F04" modified="2011-04-05" version="1">MHLLHPYRNSVWKANDHNWRVCVDSLNKCLNCIAQPRLYSSEQTIALVFGLVCLGVDAWAVYCTVQYFNRGRVELGPGDHTFGLASLFLEPMLAISILFLLGFAFSSRAHGKEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D9</accession>
    <name>E8X7D9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4425</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573092.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71373">
        <property type="protein sequence ID" value="ADW71373"/>
        <property type="gene ID" value="AciX9_4425"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4425"/>
    <dbReference type="HOGENOM" id="CLU_137390_3_1_0"/>
    <dbReference type="OrthoDB" id="2016615at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021866">
        <property type="entry name" value="SpoIIAA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038396">
        <property type="entry name" value="SpoIIAA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11964">
        <property type="entry name" value="SpoIIAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="17162" checksum="C6D979668F3A8674" modified="2011-04-05" version="1">MIERLKESGGPAFGFKVIGELTTSDIAAICQQIDFAIDERRKPIGILADLTGMLGSGWGARWDEMRFLQRHTAHISRMAVVSDNRWEEVAEMIVVATAVLQAETLYFHSSEMIQAWRWAKMTKFDEREPVRIMYPGTGLFKDYTPEFTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F5</accession>
    <name>E8X7F5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter, type IV (Conjugal DNA-protein transfer or VirB) secretory pathway (IVSP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573108.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71389">
        <property type="protein sequence ID" value="ADW71389"/>
        <property type="gene ID" value="AciX9_4443"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4443"/>
    <dbReference type="HOGENOM" id="CLU_2478980_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007792">
        <property type="entry name" value="T4SS_VirB3/TrbD/AvhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05101">
        <property type="entry name" value="VirB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9924" checksum="4A84A94101F3B95B" modified="2011-04-05" version="1">MTRRGEPLPINQAMNRSRAKLGLELPTWMAIAFVSIVVFLAGFRFTAILTFPTLVLGAWLTVRTHPKMFQIWGLSLGQKAYYDPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7K1</accession>
    <name>E8X7K1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71435">
        <property type="protein sequence ID" value="ADW71435"/>
        <property type="gene ID" value="AciX9_4490"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4490"/>
    <dbReference type="HOGENOM" id="CLU_2508076_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="9480" checksum="B0F1537080E7383E" modified="2011-04-05" version="1">MNANTIIFLFGCYCTVNFLCALALDRSVASHSRKLPPTTERVLSLAVFTLLGIPLVTLMMLWHSSKRSDSLTNYDARPRSQFGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7N8</accession>
    <name>E8X7N8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4535</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573191.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4535"/>
    <dbReference type="EnsemblBacteria" id="ADW71472">
        <property type="protein sequence ID" value="ADW71472"/>
        <property type="gene ID" value="AciX9_4535"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4535"/>
    <dbReference type="HOGENOM" id="CLU_2478982_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="87" mass="9684" checksum="37753610E7981018" modified="2011-04-05" version="1">MTEDQYSVRFGYRKAAVGFHVVAAAVRRGETPVFVRGKRFLRLDQLIKDVPSVYPPSSSERTETTPVRVSDLVLLSLGFDPLAFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVB4</accession>
    <name>E8WVB4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0215</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0215"/>
    <dbReference type="EnsemblBacteria" id="ADW67289">
        <property type="protein sequence ID" value="ADW67289"/>
        <property type="gene ID" value="AciX9_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0215"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021843_0_0_0"/>
    <dbReference type="OMA" id="AHDATWM"/>
    <dbReference type="OrthoDB" id="1123871at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="744" mass="81875" checksum="0B82822BAB2FE8E9" modified="2011-04-05" version="1">MRIKLQGQPFEVLRVLLERHNEIVSKEELQARLWQDGTTVDFDHSLGTAVNKIRQALGDSAENPRFVQTIARRGYRFIAPLRFLEEAPAELPAEEAVPLSAVIQSAPSRGHAAATNRIVSLSESVVPAPEARLAPARPHLVPPIPVALEDPYPDEPSRRHHLAPILITEAAVLILVAFLAFTWWRSAQHPTPFAIHQITFSGMISPGEPEMEALPSLATDGPRLIAPIITEGASRLSQVSISEGQTTSLDLPPDIAGPAIGDISPDGTRLLVRNHLEGAPEQALWIVPTLGHEARRIPNLLAHDATWMPDGRHILFANGSSLFLAADDGSNVRKFADLSGRAFWLRWSPDGKLLRFTLLDPATHNTALWQIASDGTHPQAVFPANTAPTNECCGSWTSDSRYFVFQSTRGAASANATQNIWAVDNQHRWLDSNPFQVTNGPLSYQGPATARTGHTIFFLGLNARMSLLRFDLATHQFKPLRQDSSMMGHTQVSYDGRWIAWINQSDGSLWRSRADGSERLQLTSAPTEVFRMHWSADDLQLAIMARQPGTPWKISVLSNAGGSSQPLLDERRDQADPSFSPDGRQVVFGRPPDLMGVERDPKSIAIVDLATHRVDPLPGSAGLFSPSWSPDGHYISAFPLDQSGIRLFDTRTHTWRNLITRSAADPAWSHDGKWIFFHAFAEPGSPIYRVNVDSGELIRITGLSDLANTDVVDFYFSGLTQDDAPIITARMSTANAYSLNLDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVC0</accession>
    <name>E8WVC0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0221</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578623.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0221"/>
    <dbReference type="EnsemblBacteria" id="ADW67295">
        <property type="protein sequence ID" value="ADW67295"/>
        <property type="gene ID" value="AciX9_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0221"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_0"/>
    <dbReference type="OMA" id="WDVIRCA"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="345"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="456" mass="50080" checksum="7B2099E658442D00" modified="2011-04-05" version="1">MTLAEWLARIAPNETGMRLAEIGVIGLGYVGLPLMLLLSEDGFRVTGLDIDEEKVRTLNAGQTYIHRIEPAHIQKAQSTGFRATIDFSAVRALDAILICVPTPLYPDHTPDMRSVVSTIEAIAPHLRPGQLVVLESTTYPGTTEEIIVATIERHGNKVMRATSGDLQQSLDGVMVAFSPEREDPGNTTTPRRDIPKVVGGVDPCATAAACALYGVLFAHVVPMSTPAAAEMTKLLENIYRSVNIALVNELKQLCLAMNIDIWEVIAAASTKPFGFQAFQPGPGVGGHCIPVDPFYLTWKAKQYGFPTRFIELAGEVNESMPRYVVQTTARALERNGASLNGAKILILGVAYKRDVDDLRESPALTIIHLLRTEGAIISYNDPFLPRVGTGRHYDLKMESTPLVDLERFDCVLIVTDHSAYDYDDIVSHSRLVIDTRNATRHLKLEEPELLAKIVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVH5</accession>
    <name>E8WVH5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
            <ecNumber evidence="2">3.5.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1363</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.3.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579746.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1363"/>
    <dbReference type="EnsemblBacteria" id="ADW68423">
        <property type="protein sequence ID" value="ADW68423"/>
        <property type="gene ID" value="AciX9_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1363"/>
    <dbReference type="eggNOG" id="COG2957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037682_0_0_0"/>
    <dbReference type="OMA" id="WCRDHGP"/>
    <dbReference type="OrthoDB" id="771174at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="360" mass="40765" checksum="6D8351030F2201E6" modified="2011-04-05" version="1">MSSHQSSPPFRMPAEWEPHAATWLAWPHNPEDWPNKFQPIPWVYAEIIRHLSRVEEVHILVNNADAERRADSILKRGGANRSRVHFHQWPTDRVWMRDSGPIFTKNPAGDLSITNWRFNAWAKYDNWHRDDLVPHMVAEHYAMPERRPEARQPDGAPHRLVLEGGSIDVNGAGTLITTEECLLSEIQQRNPGLGDEKATREQLEIAFREHLGVQQTIWLNRGCAGDDTHGHVDDITRFVGENKIVTCVEPNTADENHLPLAENLARLRAARNLKGEPFEIVTLPMPCPVVFESQRLPASYANFYIANGLVLVPTFNDACDRHALNTLAACFPDREVIGIHAVDLVWGLGTLHCMSQQEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVL4</accession>
    <name>E8WVL4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2511</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580858.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2511"/>
    <dbReference type="EnsemblBacteria" id="ADW69543">
        <property type="protein sequence ID" value="ADW69543"/>
        <property type="gene ID" value="AciX9_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2511"/>
    <dbReference type="eggNOG" id="COG5267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026001_0_1_0"/>
    <dbReference type="OMA" id="WMNTGAL"/>
    <dbReference type="OrthoDB" id="637794at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="678" mass="73650" checksum="BC8C1E36C75C8AB4" modified="2011-04-05" version="1">MKNLGTAILLISVAPLCGGQRGADGVAKLKLPPSKIALNAPLTTRERAVQILNRFTYGPRPGDVEAVMDGKWFDQQLNPGSIPDGPLEKRLGDYPTLRMRSDQLQDVFPDRGAIQLVADGRRPYPLDPLIAGVYEVEVAKLLAEREDKQHPHAELTDAEKAAAKKADQATASRVAGVLFSMPKGQRMAALNAMPVEDRIAFANNVSGDQKNTLMADFNPREREAVNAIQGGVGAQYRAYDELAQAHVLREVLSERQVQEVMTEFWFNHFNVFFNKDSDQWYTTSFERDVIRPNALGKFRDLLLATAESPAMMVYLDNWLSIGPNSLANGVDPKKPNSKPGNKGLNENYGREVMELHTLGVGGGYSQADVTHLSAILTGWGVDRPNMGGGFQFDPKRHEPGTKEWFGHTIDEQGRVEGKALGGNNPDGMKQGVAALTLLAAAPQTAHFISFLLAQRFVADEPPAALVDRMTKSYLDSDGDIKVVLTTLVTSPEFNSHRYFRNKVKTPEEFLASSFRAMATDPSNPGAVVGKLRELGEAPYQALPPTGYIMTADHWMNTGALVARLNFSDQLTHGKFGGQKFDSSRVLAFGLMADRGAGAVAQAPAVKGKVRALPVAASDPMGPDVALRVLEGTLIGGEVSVKTDEFIHSQMAAQPASNPTETLNLLTALLLGSPEFQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVU3</accession>
    <name>E8WVU3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3701</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3701"/>
    <dbReference type="EnsemblBacteria" id="ADW70702">
        <property type="protein sequence ID" value="ADW70702"/>
        <property type="gene ID" value="AciX9_3701"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3701"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047810_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="448" mass="48063" checksum="780FDB751EC3692E" modified="2011-04-05" version="1">MLKAKIKGTGTPGDVALVLMHFLGGSTREWDEVVGLLGDGFRTVAVDLPGFGEAAGEPGYSVAEMADAVEELIARLELGRYVLVGHSMSGKVSAVLARRAAETAHGRLAGLILVAPSPPSPEPMTDDKRAGMLESLGAAKDGDEARAKVYIGRNEERDIPPAVLARTVDEVLKMNRAAWVAWLESGSREDWGERVGVLDLPALVVAGEKDASLGEDSQRKFTLRHFSRAELKVVEGCSHLVPLERPTELAEMMRAFVAELGRVPVPAEYLEFIASERVSPRTRAVLEARMAGPEPTDMLTPEQMVTLRAMLARIVPQKGEGIDLAGYVAASLAKGKGDGWRYAVLPEDAKAYRDGLDSLRARGFDEMSDEDQDAALRALEEKKGSAEACWFEEVRGDATTAYISHPATLARIGHSGIGVGGANTQNKGFVAIGIGDVEAWEPKELVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVW6</accession>
    <name>E8WVW6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">AciX9_3724</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582034.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3724"/>
    <dbReference type="EnsemblBacteria" id="ADW70725">
        <property type="protein sequence ID" value="ADW70725"/>
        <property type="gene ID" value="AciX9_3724"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3724"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_0"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="327" mass="35705" checksum="C253229751ED7073" modified="2011-04-05" version="1">MRLVRLLFLLILVGAAAFVFLVPFGPHTETFVDIPSGTGTQGMAARLKRGGVIRSAFAFEALRALRGGRLKAGEYRFDHPAPLNEIYARIAKGDVYTIQVTIPEGYNIFDIAQTIQGAKLAEADAFLAAERRDTGLIRDLSPQAASLEGYLFPDTYRFSRHTTPDQMVATMVKRFRQVTAGLGLAPGPDTARTVTMASLIEKEVRVDSERPLVAGVFVNRLAQGMPLATDPTVAYAALLDGRWRGTIYQSDLASDSPYNTYRHAGLPPGPIANPGVAAFKAALQPAKTDFLYFVADAQGHSLFSRTLKEHNERVQAYRLAEKAAHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVZ2</accession>
    <name>E8WVZ2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3751</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582059.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3751"/>
    <dbReference type="EnsemblBacteria" id="ADW70751">
        <property type="protein sequence ID" value="ADW70751"/>
        <property type="gene ID" value="AciX9_3751"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3751"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_0"/>
    <dbReference type="OMA" id="RTHHTNM"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="323"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="576" mass="62696" checksum="CBE92448B657D377" modified="2011-04-05" version="1">MFFVRGVAASFVLASAVVPLAIAQKHVDKVPSYYGAQPATEDIDLTMYSRIREEGLKHSHVMEFGGALSDGIGPRLTGSPNMAKANAWTRDTLTKIGLENAHLEDWGEFGMGWQQINTWARMVGPDPEPLWCQAAPWSPSTKGPVTGELVYIDPATADAAKLKGTMTGKIVLLGAMRPTPDITEPLFKRYTDAELKEMESYPTAGGRPGAPNIQQLMADRVRMQAQRAALLKVVLADNPAAIIQPSRDSGGGGGTGVIFDDNGANLSRNAQSREGAVNVPSAVMMIEHYNRLARLITNHVPVSVEINIETKFTGDHEHGFDTVAEIPGTDPKLKNEVVMVGGHLDSWISGTGATDNGAGSIVAMEAVRILKALNVPMRRTIRIALWSGEEEGLFGSGGYVKQHFGTFNDPPSDPNVPAFLRAHGPLTTTKEWETLDAYYNLDNGTGKVRGVYTQENWAIGPIFKQWIAPLADLGVSTISYRNTGGTDHLSYDAVGLPGFQFIQDPMDYETRTHHSDMDTYDRLHQADLEQAAVVEAIFLYNTSQREAMMPRKPFPHPETDKARSAAIEGIYPGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW22</accession>
    <name>E8WW22_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0254</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578656.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0254"/>
    <dbReference type="EnsemblBacteria" id="ADW67328">
        <property type="protein sequence ID" value="ADW67328"/>
        <property type="gene ID" value="AciX9_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0254"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_0"/>
    <dbReference type="OMA" id="HGKRAQC"/>
    <dbReference type="OrthoDB" id="490746at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="36"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="518" mass="55118" checksum="6DBD0A159AE0C2EF" modified="2011-04-05" version="1">MATLVSSVSGAAEAEQAVRKLTHWIGGTAVAGTSGRFGDVYNPASGRVQAHVPLATDAEVDAAVQAAVAAFPSWSAQPPLRRARVLFRFREIFERRLDEVAALLTSEHGKVNSDARGECTRGLEVVEFATGIPQLLKGEYTEQVGPGIDSWSMRQPLGVVAGITPFNFPAMVPMWMFPIAIACGNTFVLKPSERDPSVSLLLAEMLKEAGLPDGVFNVVHGDKSAVDAILQHKQIQAVSFVGSTPIAEYVYREGTKTGKRVQALGGAKNHMIVMPDADLDQAADALVGAAYGSAGERCMAISVAVTVGAQTADALIGKLESRIASLKIGDGADDKPGHAVDLGPLVTKVHLEKVSGYLATGQSEGAELLVDGRETALPAGDGFFLGACLFDHVKPEMKIYREEIFGPVLGIVRANNFETALGLINEHEFGNGTSIFTRDGDTARDFANRVQCGMVGINVPIPVPMAFHSFGGWKRSLFGDHSVYGPEGVRFYTRIKTITSRWPTGIRAGVDTTMPTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW25</accession>
    <name>E8WW25_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0257"/>
    <dbReference type="EnsemblBacteria" id="ADW67331">
        <property type="protein sequence ID" value="ADW67331"/>
        <property type="gene ID" value="AciX9_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0257"/>
    <dbReference type="eggNOG" id="ENOG502ZFGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088882_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234091" evidence="2">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="255" mass="26128" checksum="290AA9490D1B3BAA" modified="2011-04-05" version="1">MTRTLSLLTATCLSAFALAASGQAPAAGPADGITMEMMPITADQISQCRGQATSQLASEQDTLHKREHGQDNDKMKQGAVTGITGAATSAISRKSGYGWWGGNNNGAQTAAATGATQRTDRNSDNVASTTAIGQQVGTDAYSQCVAGIKGPEYVHFRQTGQITAFTGSAPTAAPSPAIAAAAPVAPPPMAKAPVQDTGDGKHFILTAPGQTDAREVTLVTGSKNSYIEETTGDKYIVMPDGSVTRIAKRAAAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW36</accession>
    <name>E8WW36_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PAAR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0268</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E8WW36"/>
    <dbReference type="STRING" id="1198114.AciX9_0268"/>
    <dbReference type="EnsemblBacteria" id="ADW67342">
        <property type="protein sequence ID" value="ADW67342"/>
        <property type="gene ID" value="AciX9_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0268"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705488_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="391" mass="40809" checksum="FAD0DB7DE4A866CD" modified="2011-04-05" version="1">MPPAARVTDMHTCPMVTGIVPHVGGPILPPAAPTVLIGFLPAARVTDMLVCVGPPDIIVKGSAGVFINFLPAARMGDMTAHGGVIILGEPTVMIGEIGSPSPGAGGIGGIVAGLAGAGLDPNSANQSKYAHNAKNHKLQSPCIGKGLAASANEKAFAKDMKQLQKDWKTLTPAQRQQHMKDMVNKQLAKSGVPTVGISPNPTMGPGTNGQMNFQNWRLDMNPALMNSPDLTNQQTEDLGNTLYHESRHAEQWYLIGRKEAGEGKTAAQIRQSTQMLGSTATAAAAHPLAKNDPMAACAGQMFNSVYGTGAAHRNTVLTALGPNRTAYNAALANYNAVNANPASTLAQKQAAYAAYQSAAATDTANYNQYRALPEEADAWHAGNSVGSLLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW93</accession>
    <name>E8WW93_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ordered locus">AciX9_1418</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579798.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1418"/>
    <dbReference type="EnsemblBacteria" id="ADW68476">
        <property type="protein sequence ID" value="ADW68476"/>
        <property type="gene ID" value="AciX9_1418"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1418"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_0"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="428" mass="46946" checksum="3A4A13106BFC877C" modified="2011-04-05" version="1">MKTSRGSDESLRCSFCHKAQDAVAKLISSPSDYPRAYICDECVAVCNSILEDDRTEAAPGAAPAHLPKPQEVRASLDEYVIGQDQTKKKLAVAVYNHYKRIQMNKTRGNDVELAKSNILLVGPTGSGKTLLAQTLAKVLDVPFAIVDATTLTEAGYVGEDVENIILKLLQAAEGDVTRAQQGIIYIDEIDKIGRKDENPSITRDVSGEGVQQALLKLLEGTVANVPPQGGRKHPHQEFTAVDTTNILFICGGAFVGLEKVIGRRVGKKALGFKTLTDAEKLDGDVTPIRAQRDAELLRQAEPQDLLKYGLIPEFVGRLPVMGVLDELDEVALIEILTKPKNAILKQYIKLFDFEGVKVTFTDDAAREIAREALQRKVGARGLRMILEELMLDLMYYVPGNKKVKELSITAEMVKKHSLTLPMLLEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWK7</accession>
    <name>E8WWK7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2646</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2646"/>
    <dbReference type="EnsemblBacteria" id="ADW69671">
        <property type="protein sequence ID" value="ADW69671"/>
        <property type="gene ID" value="AciX9_2646"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2646"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="YKHQEIA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="213" mass="23831" checksum="179549021DDC9F91" modified="2011-04-05" version="1">MTQEKPNPGLFKRNPPIAGEAEAIEAAKNGDPDAFSKLYSLHKRRVYTLCLRMLGNVSEAEDMTQEAFLHLFRKLGSFRGESAFSTWLHRLTVNLVLMHLRKKGLNLVSLEETISPSEEDAPKRDFGSRDPMLSGSVDRVALERAVASLPPGYRMVFVLHDVEGFEHNEIATMLECSTGNSKSQLHKARLKLRELLREQVSSTQPAVLKEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS4</accession>
    <name>E8WWS4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0330</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578730.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0330"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="ADW67402">
        <property type="protein sequence ID" value="ADW67402"/>
        <property type="gene ID" value="AciX9_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0330"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_0"/>
    <dbReference type="OMA" id="KATKNMF"/>
    <dbReference type="OrthoDB" id="595845at2"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233929" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="23"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="584" mass="62006" checksum="ED775F9A6E2E98CF" modified="2011-04-05" version="1">MSCFRKAVAFGVTGIMAVSAGAAPQKHAMVVSIHHDASDAGLEILKQGGNAVDAAVAVGFALSVVLPQAGNLGGGGFMLIRDHNGEAHFLDFREKAPAGATPNMYLDQAGNIIPGLSTRGYLAIGVPGSVAGFAYAQKHYGKLTLAQDMAPAIKLAKMGYTLSEEEARALHSTNLTKFPESHRIFQRDGDYYKTGDTFVQPELAKTLQRLAANPQEFYTGPMAKQLADTVHTHGGLLTEADLAAYTVADRKPLVGHYSTGGQKYDVVTSPPPSSGGIVLLEVLNMLSGYDLPKLGGDRSEAQMHIITEAFRRAYMDRGDYLGDPDYTVLPLAQMGNERYASAWRKTIDPVKPTPSAELRRPAGFMPPPPAVTPVKESTQTTHFSVVDSDGNAVSTTYTLNGLFGCGATAEGLGFLLNNEMDDFSSKPGSPNMFGLIQGPANAIAPGHRPLSSMTPTIVTAASKHGKPGELRLVLGSPGGSTIITTVINDLLSILVNGLSVQAAADAPRFHHQYLPDVLDVEKAFPVPVVEELRAAGYKVSRANEADEKNPGVWGDSELIEVNPKTGALEGGHDNRRKFGKVASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWS9</accession>
    <name>E8WWS9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0335</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0335"/>
    <dbReference type="EnsemblBacteria" id="ADW67407">
        <property type="protein sequence ID" value="ADW67407"/>
        <property type="gene ID" value="AciX9_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0335"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_0"/>
    <dbReference type="OMA" id="GATACIH"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="314" mass="33825" checksum="BAB94F377A86564F" modified="2011-04-05" version="1">MTIENFRLIVFRAVARHSSFSRAAEELLLTQPAVTQQIKALEEQFGHPLFHRGGGRISLTPGGAALLPFAEQIKVLSEEAFTAVAKAYGQEAGELSVGASQTIAQYLLPTFLAAFLQRNPDVRITVRIGNSDQMLAALVSGEIQVALLEGPELRTDVHIEAFMEDHMVLVVPASHEWAGRKVTLDELRTQPLLVREFGSGSRRIVEQALAGVGLKTKDLNIRMELDSTEGLLNGAEAGLGVTFVSRWAVRNQLALGTLTLARVEGLKLSRSFSVAYPAGPEPIGSVGAFRSFLVGYAASVAPRRATKKQGLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX03</accession>
    <name>E8WX03_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vitamin B6 biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1511</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579883.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1511"/>
    <dbReference type="EnsemblBacteria" id="ADW68564">
        <property type="protein sequence ID" value="ADW68564"/>
        <property type="gene ID" value="AciX9_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1511"/>
    <dbReference type="eggNOG" id="COG0214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_0"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="4">
        <location>
            <begin position="9"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="33735" checksum="7913E4B30515C176" modified="2011-04-05" version="1">MSSTPTSLRLKTGLAEMLKGGVIMDVMDVDQAIIAEAAGAVAVMALERVPAMIRAEGGVARMSHPGMIKAIQKAVSIPVMAKVRIGHFVEAQILEHLAVDFIDESEVLTPADELHHIDKHAFKTPFVCGAKDLGEALRRIAEGAAMIRTKGEPGTGDVIHAVKHMRKITSEMKALTVLSEQELYAAAKELRAPYELVKLVAETGQLPVPNFSAGGIATPADAALMMQLGAQTVFVGSGIFMKEGNIRLDVSLVDGKPLNPSERAEAESRAKAIVRAATHFDNPEILAEASEDCLGAMKGLAVGMIAEEDMMQHRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX08</accession>
    <name>E8WX08_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1516"/>
    <dbReference type="EnsemblBacteria" id="ADW68569">
        <property type="protein sequence ID" value="ADW68569"/>
        <property type="gene ID" value="AciX9_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1516"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_2_0"/>
    <dbReference type="OMA" id="MFTFGYR"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="749" mass="79862" checksum="2C5B10D8699B4173" modified="2011-04-05" version="1">MSILEAAQEETAKKPIKQLDHRYDGIAKVTGKATYAGDFKEPFAKDDLLYAWMVQSTIANGTIASMDSSAAEHAPGVVAVMTPFNSPKIPQPPAQPPARRNLTILQNTDVKYNGQPIAVVVAKTLVQARQAATLLKIKYTEQPAKVIYQDHLADARWPGNPGKEPAGNTRGDIAAGFAKATVTVEGTYTTPIQVHNPMEPHATIAWWEGEKLNLYDATQYITGVKMSIAKTLNIPLDFVRVQCPYTGGGFGSKGSSWSHIPLCAMAAKLTGKPVKLVLDRSQMFGPVGARPSTVNKIKLGATADGKLVAMQQNVIMNAAALEDFTEHSAGPTKMLYMSENNQVSEKLVTVNLGVSTFMRAPGEAPGTAVLEIAMDELAEKLKMDPVQLRVINHADKDPSHDRPWTSKNLKQCYTQAAERFGWSKRSATPAQMTEGNNLIGYGMATATYPANRSAAMAIARILPNGRAFIGSGTQDLGTGMYTIMAQTAAAMLGLDPTLMDVKLGDSTLPKAPVSGGSQSTASVMPAVQEAAMQAKLKLFDMAVNDTASPVHGMKTSDLEAKGGKYFAKADPTKGETFVAIIARNGGKPIEATGSAEPSESKDSMTSQSFGAVFAEVAVDKDTHMVKVRRVVATYDIGTLLNDKTGLNQLMGGIVWGVSFATHEDAHIDPNTGRTVNESFAEYHVPVNADIGTIDATVLNIPDLKFNPLGARGIGEIGITGAAAAVANAIYNATGKRIREYPITPDKLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX54</accession>
    <name>E8WX54_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2672"/>
    <dbReference type="EnsemblBacteria" id="ADW69696">
        <property type="protein sequence ID" value="ADW69696"/>
        <property type="gene ID" value="AciX9_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2672"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_0"/>
    <dbReference type="OMA" id="HKGSMYH"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="22184" checksum="64246C0E4698C592" modified="2011-04-05" version="1">MCDAGFLEVAMSKGETTRERIVREAAPLFNQKGFAGCSVQDILNATGLEKGGLYRHFASKQELAVEVFRWATAQSQRSRTDGMEHIENAVDRLKFHVARFAEAPSLVAGGCMLLNTAVDADDVNPELKAMACDAIQRWKRRIAAIVEYGMARGEIKAGTTARRVGNTIVATLEGALVISRLEGTKDALEDARESLGVMLEGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK1</accession>
    <name>E8WXK1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M16 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1564</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579936.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1564"/>
    <dbReference type="EnsemblBacteria" id="ADW68617">
        <property type="protein sequence ID" value="ADW68617"/>
        <property type="gene ID" value="AciX9_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1564"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_3_0"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="182"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="436" mass="48552" checksum="2277A67CBF107E97" modified="2011-04-05" version="1">MSATQSAEHPRTHAPRNIRKTILPNGMLVLTESMAHMRSISMGAWIKQGSRDESAPENGISHFVEHMVFKGTPTRSAQDIAREVDSIGGNLDAFTGKETVCFNIKVLDENLPPAMDVLSDLVLNPKFSPEDLEREQGVILEEIKMDEDSPDSVVHEVFTQNFWKNHPLGRPILGTVKTVSSFNQQTVIDHHKHRFTPANIVFSAAGHLEHDAFVERVERAFGHLPAAPPSPQIDQHPTITPHITLKKKKSLEQVQLCLGMPAPPVQSTDRFALYILNTILGGGMSSRLFQSVREEQGLAYSIFSELSPFRDTGSLSIYAGVSLDKTEKTLQLTLSELRRLKEEIVPDAELKRAKDQMKSNIVLGLESSSSRMSNLARQQMYFSRFFTVEDIVQEIDAVNPADLQRIANDLFRPELLALTLLGNLGPMKVSRADLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXM7</accession>
    <name>E8WXM7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_1590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579962.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1590"/>
    <dbReference type="EnsemblBacteria" id="ADW68643">
        <property type="protein sequence ID" value="ADW68643"/>
        <property type="gene ID" value="AciX9_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1590"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_0"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="565" mass="61117" checksum="B92B7DA9C1EF0438" modified="2011-04-05" version="1">MLLELRAENYAVIDRAAARFGRGLNLLTGETGAGKSILIDALALLLGGKASADFIRHGAEKAVVGCVFEATPGAIAVLEANGIDADSESEGILLRREIVVSGKGRVFINNQPATVGVLRLLAPELALVHAQGETLGAFDQAQQRILLDRFAGCSLEEVGKAYSAWRGTVAKLEEMNSAEQDRLRMADLWRFQSMEISDAGIAGESEDAELEGEKRVLANAEKLYTAAMNAHELLYESEDSAETKLGAALKLVEELARYDARFVEAAGQLAAAKATVEDLSATVRDFAENVQSGPERLAEIEDRLAVLDRLKRKYGKTLAEVIAFGESSARSLAEVENRDALLAELRVVEAKQAESYCAAAGELTRVRGEAAAKLERLAEKQINDLAMSVRFSIQVLANEERVHWGAGGWDEVRYLIATNAGEPLKPLEEIASGGEMSRVMLALKVTVEEGVAGRGSKRKTALPRTLVFDEIDIGIGGRAAEAVGQKLKMLSRTQQVLCITHLPQIAAFGDLHFVIEKKEVGGRTQTNIRQMEDVERVNEVARMLSGAKLTETSLKHAQSLIDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN5</accession>
    <name>E8WXN5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1598</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1598"/>
    <dbReference type="EnsemblBacteria" id="ADW68651">
        <property type="protein sequence ID" value="ADW68651"/>
        <property type="gene ID" value="AciX9_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1598"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_0"/>
    <dbReference type="OMA" id="FIWATRT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="120"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="35164" checksum="C6AA7183E21113AF" modified="2011-04-05" version="1">MGCAMWKRLVVLVIWVAAWGGMPGAAQGVWQPLAGHVQMAIWPGAVPDARAETGAEVLKTASDPKDQVAGRQWLSVEQVSRPTMTVYSPKSGNTGAAVVVFPGGGYSVLAIDLEGTEVCDWLTSRGITCVVLKYRVPDSGPAYHNDCHCNIRPKAQTALQDAQRTMGLVRLHAAEWHIDPHKVGVMGFSAGGHMVANISTHFERRAYAPVDAADKLSCRPDFAVAVYPGHMTEHTTREFELNPEVPVTAKTPPTFLVQAEDDHVDGVKQSLTYYIALMKAGVPVEMHLYAQGGHAFGLRRTKLPITHWPELVEVWLRTIGVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXU9</accession>
    <name>E8WXU9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="12" type="ordered locus">AciX9_2770</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581109.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2770"/>
    <dbReference type="EnsemblBacteria" id="ADW69794">
        <property type="protein sequence ID" value="ADW69794"/>
        <property type="gene ID" value="AciX9_2770"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2770"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_0"/>
    <dbReference type="OMA" id="NVRRTMG"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="933" mass="103088" checksum="6110A00BD5AF7EAF" modified="2011-04-05" version="1">MSKSLVIVESPAKAKTINKYLGADYTVEASLGHIMDLPKSDIGVELLNRTFAPTLIVSPGKEKIVDRLKKLAAKADHIFLAPDPDREGEAIAAHLAMQLRPVIKAGADIRRVTFNEITQKAVKAAFLKARDVNENLVDAQQTRRVLDRLVGYQISPLLWDKVRRGLSAGRVQTVALRLIVEREREINAFVPVEYWTVDAVLQAEKTSFTARLTGIDGARITVPNGFDKDGKAQVLANALPDHATTDQVVADLANATFAVKTVEKKERKQNPKAPFTTSKLQQEAAGRLGFNVRRTMGVAQRLYEGIEIGGETVGLITYMRTDSTRVSDDAVAEARTYIGALGERYLPAKPNEYKKKNEAQDAHEAIRPTNVAYHPDEIRASLSDEQYKLYRLIWMRFVASQMMPAIFDQTTVEIGAKAARSYDFRVSGSVLKFDGFLKVYETAPAASTAEASDEDGEEEDKRLPALADGQGLVRQAIEHEQKFTDPPPRFNEASLVKTLEEKGIGRPSTYASIINTIQDRDYVKKIGNKFVPTEIGMVVTELLVKNFPYIFETGYTATLEGELDAVEAGTEKWTDLLDGFYSHLEKELAVAETTMEDIKRKEEATDEVCDNCGSPLILKWGKFGSFFACSAFSKAKAVTIAAAPWKKDPKAVLKKILGSFHFPMIVKAVTFDETNFSKEVADAKEFAEAVKSAAGKGKKITAEPVSCDFTKENFAAKPDLNAPGADEAPEEEFCDNCGRLMVLKNGPWGPFMSCPGYSDDPPCKTIRKLTQKVQSKPPITLDEPCPKCGKPLLQRDGAYGEFIACSGYPKCKYVKQELLDVKCPKDGGDLAVRKTKRGDVFYGCVNYPKCDFASNLKLVNETCPKCHSAYLLEYGNKEGTYLVCPNNREFLPKRRPKKGQPVEVPTTPECTYERLIGPPKTVEAEPEMAVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXV4</accession>
    <name>E8WXV4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2776</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581114.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2776"/>
    <dbReference type="EnsemblBacteria" id="ADW69799">
        <property type="protein sequence ID" value="ADW69799"/>
        <property type="gene ID" value="AciX9_2776"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2776"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030717_0_0_0"/>
    <dbReference type="OMA" id="VINILFF"/>
    <dbReference type="OrthoDB" id="596088at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="434"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="607" mass="65850" checksum="742F899997671538" modified="2011-04-05" version="1">MQNSSLSPHANNRPQTQGEVEAHYIELRKQHQTRQDGFAARKTRIGWALIVCLGIIVALATQAHHQTSPWPLLAAFAVLASLVPVHLGLQTRISRTERLLGLYDRNLARVRSEAWQSGNTGETLHQPGHLYERDLNLLGEDSLFGLLDTVRTGIGQRGLADYLQAPAIHAETLERQQAVKELAAKTELREEIALLGTSKFQQVEARFFDTWLDEEAPVFHPAFRYVLVVTALALVVMLLLGLTHAVAWPVLLPNLALAAVLQAGISMSLRSRVLPLLERVTRLSNHVQMFSDGLAILETQSFQALKLQAIQAAARQPANAVPLLAKLQSQITIVQQRTKEYFFIFSLLLAAGTQAAITIAAWKRANGAAMKSWLAAWAEFEALNALAAYAFEHPEDAWPELLPASAQPTFEAIELGHPLLTACVRNDVSLGDATRFFLISGSNMSGKSTLMRSIGINAVLAYAGAPVRAHSMQLTPLTLGASLALTDSLAEGKSKFLAEVERLQKIVQTSAGSPVLFLVDEIFSGTNSVDRQAAAGAVLRSLLVNGAIGALSTHDLALAELANEENCGLNVHMASPDPEDPLGFDYRLKPGVNTSSNALAIIRMMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY09</accession>
    <name>E8WY09_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578876.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0476"/>
    <dbReference type="EnsemblBacteria" id="ADW67548">
        <property type="protein sequence ID" value="ADW67548"/>
        <property type="gene ID" value="AciX9_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0476"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="252"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="397" mass="44356" checksum="E03992F2D2749B82" modified="2011-04-05" version="1">MDYRTLFLANIAFMTVYTAFAVLLALHNRKIKGLSLLSAGLVVALLETILQGLDGSISPLWSSLAANELYLLTFVLQMLGLRWFVTRSSLRMRWPMVCIAVMMVSYAGLYAARVAYIGNLINIPVIVLCGTTAWMLLRRGRGLYLRVSRWTTVFLLGEMAVAFYRALLTNLHYALPWAVAAARHDSRWLDSLIAGMFVSSCVVMCDLWFFVTALESELMEQARTDSLTGALNRRALRVEGAREVARTLRSGHTLCLLLLDVDHFKELNDTFGHSAGDAALQYMVQQVRGVLRTQDLLARSGGEEFTILLPETPLDRGELVAERLRLEVDSKDFIYEGTAIHLSVSVGVATLDPHCADFEALMRRADSAMYMAKRMGRNRVMAYGAEALVDDRQINIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY30</accession>
    <name>E8WY30_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0497</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67569">
        <property type="protein sequence ID" value="ADW67569"/>
        <property type="gene ID" value="AciX9_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0497"/>
    <dbReference type="HOGENOM" id="CLU_2806437_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="67" mass="7722" checksum="0810D0F9E5124F04" modified="2011-04-05" version="1">MQEKGPGVIRETKKFLKYYSALRMLFILLRLKTEFSLDRNQSMASITVKVGLRGRLTKAKHLGIPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY42</accession>
    <name>E8WY42_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1616</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579988.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1616"/>
    <dbReference type="EnsemblBacteria" id="ADW68669">
        <property type="protein sequence ID" value="ADW68669"/>
        <property type="gene ID" value="AciX9_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1616"/>
    <dbReference type="eggNOG" id="ENOG50339H2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169594_0_0_0"/>
    <dbReference type="OMA" id="FEYRAGK"/>
    <dbReference type="OrthoDB" id="1906934at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="94" mass="10954" checksum="EDF373904597296B" modified="2011-04-05" version="1">MSLIAGVVLSLMCFAFIFWPERNPFVQADKTRVDYLRERRDAIYENLRDLNFEYLAGKYPEDDYAEQRAGLEDEAAKVIGEMEGLEARGMRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY57</accession>
    <name>E8WY57_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1632</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580003.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1632"/>
    <dbReference type="EnsemblBacteria" id="ADW68684">
        <property type="protein sequence ID" value="ADW68684"/>
        <property type="gene ID" value="AciX9_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1632"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_2_3_0"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="OrthoDB" id="1691691at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="198" mass="19990" checksum="804062A7271010F9" modified="2011-04-05" version="1">MQTAHPIQAAAPVSFVPRNATLVDKAILAVAGSVFVAICAHVSVPLWFTPVPLTLGNMAVILVGLCLGPSTAFAAMVLYLCEGAMGMPVFNPGGPAGMAHLMGPNAGYLFAYPVAAAVAGYLAKAISLRGSKYVAGIVGSVAGTALVIACGVSWLASLLHLNAAMAFKLGAAPFLPGEVIKVAAAAGIYSAIARWRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYF7</accession>
    <name>E8WYF7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2840"/>
    <dbReference type="EnsemblBacteria" id="ADW69863">
        <property type="protein sequence ID" value="ADW69863"/>
        <property type="gene ID" value="AciX9_2840"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2840"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119484_0_0_0"/>
    <dbReference type="OMA" id="RCMTTWV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22347" checksum="9375407715247BDF" modified="2011-04-05" version="1">MTIQEQFGQIDIYVFDQILRGNIGRGMRVLDAGCGYGRNLVYLLREGCEVFGVDANPEGVEHVRALASQLAPGLPPENFQVAAIETMPFPDGFADVVICNSVLHFAQDDGHFVGMVKEMWRVLRPGGLLFVRVGSRIGMSFPRVRGNVYEIGDGSEWFLVDEGMLMKLTEDLGGVMVDPLKTTVVQDYRCMTTWVLRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYK8</accession>
    <name>E8WYK8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0534</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578934.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0534"/>
    <dbReference type="EnsemblBacteria" id="ADW67606">
        <property type="protein sequence ID" value="ADW67606"/>
        <property type="gene ID" value="AciX9_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0534"/>
    <dbReference type="eggNOG" id="ENOG502ZB6P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079907_0_0_0"/>
    <dbReference type="OMA" id="HKRPAEF"/>
    <dbReference type="OrthoDB" id="842294at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="311" mass="34140" checksum="E4E1AEBB529FCFF9" modified="2011-04-05" version="1">MGGSSVGELDRVVAVDWSGDKGPGQRKKIWAGVWTRGAGRTAGGRVTLETGRTRAELTEWLVGLAKETPRMVVGMDCCFSYPSWFLRECGCSTVFEFWEYVAGGCGERWLGTTCAEEERDLRFWGRPHKRPAEFSGPGYASMMRATDWENKVAQGLEGGDPVRAALMKGVQPKSPFQIGGAGAVGTGSLRAMEWLMRLREGGFRVWPFEDFSEGRPLLVEMYTRLLTGPVAKSNPSARKAYLKARKMAEPGLYGGLARSVVVGAEGSEDGFDALVCCLEMVRWQTEFAGLRRATDETLKLEGITWRPGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYN3</accession>
    <name>E8WYN3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome segregation and condensation protein, ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0560</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578959.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0560"/>
    <dbReference type="EnsemblBacteria" id="ADW67631">
        <property type="protein sequence ID" value="ADW67631"/>
        <property type="gene ID" value="AciX9_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0560"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_0_0_0"/>
    <dbReference type="OMA" id="TKPEYHD"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="355" mass="38574" checksum="D46215E240125B8E" modified="2011-04-05" version="1">MSLKAKIEAVIYASEEPVTLAQLMGLLGHEAQAELDRMESRQQDLGLETSGDEDALGSGVEELLSDGPDMDDAEVTQPTSENPDMGHPVVEADAEAEAELTDAAIAKVSAAEKRAARERERKLREFFREILDELIKDYAVGDRGLEVREVAGGFRLGTKPEYHDAVRGFVRSLKPALKLSLQALETLAVVAYKQPVTAPEVSEIRGVDSGGVLGSLMGRKLITTAGRKQVIGRPILYKTTKDFLLRFGLKDISELPSIEEFEKMAGELVEQEEIPMPRGSDTDERVTHENLMEEKDATEPQADGDSDDLGANNSNLAKDDLPTLDGRESGLPPTYDEPGDDPSADEAAIQAEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU4</accession>
    <name>E8WYU4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribodipyrimidine photolyase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580099.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1732"/>
    <dbReference type="EnsemblBacteria" id="ADW68780">
        <property type="protein sequence ID" value="ADW68780"/>
        <property type="gene ID" value="AciX9_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1732"/>
    <dbReference type="eggNOG" id="COG3046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031632_1_0_0"/>
    <dbReference type="OMA" id="GMSQYAD"/>
    <dbReference type="OrthoDB" id="215545at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_7" evidence="1">
        <location>
            <begin position="324"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="565" mass="64246" checksum="0896E8A88D3D87A8" modified="2011-04-05" version="1">MQSFQHQIAPFAPKPADLKSRRWIYIPYDRYTDRTGPLTEQPAAQTGIVIVESTAKALRRPYHKKKLVVLISNMRHFALEQAAKGVKVLYHFSPDSHGQALLHLQQSNKLPAITCMTPAERELRLDLHQAQQQGLDITFAEDTTWASSTKDFTTVYGPYKQGKSYVMDRFYRRMRQQTGILMQNAKPIGGQFSFDADNRSPYKHEVPVPTPPTYPPDTITQEVIALVEQTYAHHFGTTEDFDLPCTQSDSDAFWQFFLTHQLPHFGRFEDAMRDDHLQLFHSKTSVLLNLGRLLAMDLIRDVAARAAEGTAPMASCEGFIRQLLGWREFMRHLHEQTDGYRLLAGHVPQEPRKVPHEFSPDAPGAPRLDSETWVQGATPSALGASLTLPAAYWGIESGLHCLDTVVKQVIHEGWSHHITRLMVLSNLANLCGFSPRELTDWFWFAYVDAYDWVVEPNVLGMATYADGGLTATKPYVSGAAYINRMSNYCGHCQYDPKKSTGPGSCPFTSLYWTFLERNEDKLSGNFRMQMPYNTLHKKKPEELVQLRTRAAEAITDLQSFKRPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW8</accession>
    <name>E8WYW8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1756</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580123.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1756"/>
    <dbReference type="EnsemblBacteria" id="ADW68804">
        <property type="protein sequence ID" value="ADW68804"/>
        <property type="gene ID" value="AciX9_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1756"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498675_0_0_0"/>
    <dbReference type="OMA" id="RFQMKVH"/>
    <dbReference type="OrthoDB" id="701763at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233503" evidence="2">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="532" mass="57560" checksum="A6B76C72070892D3" modified="2011-04-05" version="1">MRAAVALFAFLTVSSLAQAPAASKSFVIADVHVSPFNANPFMHGNSTQGDRYFLTQASMLDLIATAYGVDAANVQGGPTWLERDRYDLRAKVPAKITPDDIKLMLRGMLAERFHLVVKAGSAPLPAYVLTSEAGKPKIRESEGTDEGRCMPAPPPPNQPAGAPSYRILNCKNMAIPALADTIHLFAGDYLGQPVVDETRLAGTYDFTLKWSGKDQLEKQGADGISIFAAMEKQLGLKLELKTAPRPVFQVASVDEIPTPNAANIAEALPEPPASPFEVATIKPSTPGAEGYGRITGDQIETRAIPLMFLIRFGWDLNPNNKESVVNAPAWLDSTKFDIVAKAGANVRVDKFASGNLINYEDLRNMVRAMVADRFQMKWHMEDRPITAYTLTAMKPKLKPTTDPTERTKCKEGPGPDGKDPRVTSSVLNRLVTCQNMTLAQIGDELQRVANGYIYNTVVDGTGIKGSYDFTLSFSSADKVQPGAGDAAVGSDPNGALSVFDAVSRQLGLKLEKTKRPSPVLVIDHIEETPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ10</accession>
    <name>E8WZ10_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-amino-acid oxidase</fullName>
            <ecNumber evidence="2">1.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2902</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581240.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2902"/>
    <dbReference type="EnsemblBacteria" id="ADW69925">
        <property type="protein sequence ID" value="ADW69925"/>
        <property type="gene ID" value="AciX9_2902"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2902"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_8_3_0"/>
    <dbReference type="OMA" id="YTHAWIA"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="542" mass="58875" checksum="57D80BB7252F25C1" modified="2011-04-05" version="1">MGITRRGFLTRVGQAGGYSATMIAMQSLGLMPAKALEAPNFAAAPGTGNGVKVVILGGGIAGLVAAYEMKALGYECTVLEARERPGGRNWSVRGGDKITFTDGTTQTCEFDAGHYQNVGPARLPSVHKTILGYCKKLGVELQVEVNTSRSSFLQNDAANGGKPVIQRQAINDTRGHVSELLMKCMKQGALDQEMDKTDRDKMLSFLRTYGSLDDAGKYKGGDRAGYKVLPGAGDQVGEPSDPIDMHTLLDESFWNGMLFEETFDMQATMFQPVGGMDRIPYAFAKALGDTVQYSSPVTEIRKSGKGVKIGYKQTGVAKFIEADYCICAMPLTILKKTPNDFAAPYKKVIEECTYASAYKVAWESRRFWEQDYNIYGGLEFVNTGCSPIWFPSANMFSERGVVVSGYTDESNSPFGKLAMPEKLVESRKSIERLHPGHGKELEKPIYVGWGKIPYNEGSWIRAYGPGQGRGPAATITRTGTPTETKRAATATNEGYETLIQPDGPIYFAGCHVSHIVAWQEGAALSSLRAVGLINDKVKAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ28</accession>
    <name>E8WZ28_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2920"/>
    <dbReference type="EnsemblBacteria" id="ADW69943">
        <property type="protein sequence ID" value="ADW69943"/>
        <property type="gene ID" value="AciX9_2920"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2920"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_0_0"/>
    <dbReference type="OMA" id="GPCANKV"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7755" checksum="92E2D85E76E2B7BA" modified="2011-04-05" version="1">MAQYKGQVKWFNNAKGYGFLGRDGGSDVFCHYSAVQTDGYKSLKEGDEVEFDIIDGDSGKPQADKVICLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ39</accession>
    <name>E8WZ39_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ordered locus">AciX9_2931</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581269.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2931"/>
    <dbReference type="EnsemblBacteria" id="ADW69954">
        <property type="protein sequence ID" value="ADW69954"/>
        <property type="gene ID" value="AciX9_2931"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2931"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_0"/>
    <dbReference type="OrthoDB" id="2066169at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="37" mass="4303" checksum="AB40A891B18644F7" modified="2011-04-05" version="1">MKVRASVKKICDKCKVIHRRGVVRVICENAKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ47</accession>
    <name>E8WZ47_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ordered locus">AciX9_2939</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581277.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2939"/>
    <dbReference type="EnsemblBacteria" id="ADW69962">
        <property type="protein sequence ID" value="ADW69962"/>
        <property type="gene ID" value="AciX9_2939"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2939"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_0"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="121" mass="13286" checksum="27875BE91580644F" modified="2011-04-05" version="1">MISPRQRNVIRQRVHTRIRAKMAGTAERPRLNVYRSLNHIYTQLIDDANGVTLASASSKGKKGEEAKSGGNVEAARLVGKLIAERGVEKGIKKVVFDRGGYLYHGRIKALADAAREAGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ57</accession>
    <name>E8WZ57_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578987.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0588"/>
    <dbReference type="EnsemblBacteria" id="ADW67659">
        <property type="protein sequence ID" value="ADW67659"/>
        <property type="gene ID" value="AciX9_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0588"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666954_0_0_0"/>
    <dbReference type="OMA" id="FRYAVES"/>
    <dbReference type="OrthoDB" id="1034276at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="419" mass="46998" checksum="40E50E467386C719" modified="2011-04-05" version="1">MNQTQSNPFRQQHRGRHSLREAVLAAFSQPPYVVAEQLSGFSEREWKSNLKWLDTSGLALYLLGHLQELGVGEVLPTKIVLRLRRNLIDNRARNSGLLTETAEINVALQREGVLFANLKGVTLSPDAVPDPALRCQLDQDFLVSAEQADTAAHVLERSGYMLHCVSGDTWEFKAGASSVAHIRDLYKAKPQRSAELHLAPADGLLGRVQLRSFHGTAFPVLSPVDLYIEQAMHLFGHVCSPFTRTSWLLEYRRHMLARGDDEMFWEELEGRIADEPKAALALGLVTLLAVETFGDVPPKALSRLIASEVAPAVQLWVRLYGQRLLVADFPGTKLYLLLEDELQPSSARAAAKGRSRLIPSQRPLNITQAEPEESVLSRLRRSRSQTSYILFRLRFHCVEGIRYVLESSRFKRLLTGLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZJ8</accession>
    <name>E8WZJ8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ordered locus">AciX9_2949</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581287.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2949"/>
    <dbReference type="EnsemblBacteria" id="ADW69972">
        <property type="protein sequence ID" value="ADW69972"/>
        <property type="gene ID" value="AciX9_2949"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2949"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_0"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW69972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="228" mass="25953" checksum="7323A0960DF303AE" modified="2011-04-05" version="1">MGQKVHPYGFRLGINKPWKSRWFVERGYDKLLVEDVKLKAELREKLKAAGVSSVEVERPGNKLRLIIRTARPGIIIGRKGAEIDKLKADIQKRTSREVFIDILEVNKPELDAQLVSENIALQLEKRVSFRRAMRKSVDSALRFGCKGIKVRVSGRLNGNEIARSEWYLQGRLPLHTLRADIDYGFSEAHTTYGIIGVKTWVYRGDIYEQRKRRDQGASTTATAGAFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZS6</accession>
    <name>E8WZS6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0667"/>
    <dbReference type="EnsemblBacteria" id="ADW67737">
        <property type="protein sequence ID" value="ADW67737"/>
        <property type="gene ID" value="AciX9_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0667"/>
    <dbReference type="eggNOG" id="COG2184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080158_0_1_0"/>
    <dbReference type="OMA" id="FCHFEYI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="54"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="200" mass="22367" checksum="2C19B1C87EFA10E5" modified="2011-04-05" version="1">MSSGFENDPHSERGHACPRNKFGITNYAELSRFEAPLSAKRLGELEDRPMKGSFDSQHLRAIHRYLFRDVFPWAGEFRVVNISKGGPMFGPVMFIGQALDDAFGKLAREKLLSGLTVDAFADRAAFYLGEINAIHPFREGNGRTQREFIRQLAVRAGHTISWAGFTQQEMIDASIKSHVGGENEALAEILRRALMERGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW2</accession>
    <name>E8WZW2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0703</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579101.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0703"/>
    <dbReference type="EnsemblBacteria" id="ADW67773">
        <property type="protein sequence ID" value="ADW67773"/>
        <property type="gene ID" value="AciX9_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0703"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="OMA" id="DSSDAHH"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="399" mass="41670" checksum="A3EC93EDEB3E4878" modified="2011-04-05" version="1">MHRVVITGLGCITPIGNTPQALWQSVLEGRTGIAPMQVEHPGLRFTRMGEVRDFRPEDHLANGQILTTERAAQFAIVAARQAAVESQLLAHHAPDRIAIFTGCSTAGRQAEEPETAKLYTSNARVHPLTVPRSMASSGASQIAIDLHITGPALNLSTACSSGAHAIGLAFQMIRGGAVSAAIAGGHEAPLTFGFLRAWDSIRVVSPTACRPFAADRDGMTLAEGAAYLALETLESAQSRNAPIYAELLGFGMSTDAHHITQPKPEGPAAAIRICLADGKLDPQEIGYINAHGTATQANDQVEAAAIHAVFGDHASRISVSSTKSLHGHSMGASPAIETLITALALRHGQLPFTAGTITPDATLNLNLILEAPQPTGPTVALANSLAFGGLNAILALRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZW6</accession>
    <name>E8WZW6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">AciX9_0707</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579105.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0707"/>
    <dbReference type="MEROPS" id="C44.A08"/>
    <dbReference type="EnsemblBacteria" id="ADW67777">
        <property type="protein sequence ID" value="ADW67777"/>
        <property type="gene ID" value="AciX9_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0707"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_0"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="324"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="497"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="655" mass="71149" checksum="6EB9230F3F0C6820" modified="2011-04-05" version="1">MCGIVGYIGPKSVVPVIIEGLRRLEYRGYDSAGIAVGGSPEHPNKLDLRRAPGKLKNLETVIAASPIDGTYGIGHTRWATHGRPTEENAHPHRDGTGTLVVVHNGIVENYLALKKSLIAKGHTFQSETDTEIIAHVIQDELELHEKMGAPRLDSETWVSTEANESQAVLISNTPDRLPLDEAVRRAVKRLTGAFAIGVLSAHAPDTLVAARMGPPAVIGIGEGEFFLASDVPGILHHTRNIHFLQDGEVAVLTKTGVRITDFENNELPLKIQRIAWDPIQAEKAGYKHFMLKEINEQPRAVRDTTLGRVSLETGEIFLPEMQISQQEFKAATGITIAACGTSWHSGLAGKFMIERLARLPVDVDYASEYRYRDPIPDATNLGLLITQSGETADTIAAQQELIRKGSKTLAICNVVGAAITRAAQGTITTNAGPEIGVASTKAFTAQLTALFVFALYLAQQRGTITPEESLHYVTELSKIPAKLEEVLRTVDAQCCELAKSFSTARDFLFLGRGIHYPIALEGALKLKEISYIHAEGYPAGEMKHGPNALIDETLPVVCIATKDPADPSSVLKYEKTLSNIQEVTARSGRVIAIAVEGDHEITQLVEHTIHIPAAPELLLPILEVVPLQLLAYHIAVRRGCDVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X063</accession>
    <name>E8X063_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3023</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581358.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3023"/>
    <dbReference type="EnsemblBacteria" id="ADW70044">
        <property type="protein sequence ID" value="ADW70044"/>
        <property type="gene ID" value="AciX9_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3023"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="33833" checksum="8476B5758902EB03" modified="2011-04-05" version="1">MIVEVQGLRKVYEGKQQVTAVDGIDLSVGAGEIFGLLGPNGAGKTTTISICTTRALPTSGIVRIAGVDVVKDSALARRSIGVVPQYNTLDRACTIAENISFHCLYFGFSRADARARTAQLLDQFHLTERTGAYPQQLSGGLAQRVQIARAIAHRPKVLFLDEPSAGLDPQSRIAMWDAVRGLRDEGITVVLTTHYMEEADELCDRVAIIDHGKILVQDTPAALKNSVGAQKVYQLHLRDHDSTAALLETLRKLPGIITAENLSDGVRVLAHNADGLLSDVVGAANPYGLRDLTITETSLETVFIQLTGRDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X080</accession>
    <name>E8X080_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3041</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581375.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3041"/>
    <dbReference type="EnsemblBacteria" id="ADW70061">
        <property type="protein sequence ID" value="ADW70061"/>
        <property type="gene ID" value="AciX9_3041"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3041"/>
    <dbReference type="eggNOG" id="ENOG502ZVJA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915074_0_0_0"/>
    <dbReference type="OMA" id="DTCVENR"/>
    <dbReference type="OrthoDB" id="1591974at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234031" evidence="2">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="330" mass="34380" checksum="99F6D7AC106E4043" modified="2011-04-05" version="1">MKSGWILLAVGCGALGTMKADAQAWTQPRVAGSVPLGEANATGILMVTGGKNILGTASVITALDRPAHVTLDRGGSILVCQTSVLKLTESQMGPADALVRDWSPQVLLALDRGAMEVRMPMLPGDALVTPDLRFTSASSKGKGEALDLAIRTTSNGDTCVENRGKKAPTLNISDSFGESSYQLKAGQHVMFEHGSLKEVNDRESTPCGCPPVGHEEISLAEAAVRRGSSKPVTAKQAAKEHPFPAAVSEGLAPPSPLPPEDPKTTHVQVATTLSYDPAADQKPAPAATGTVPPEVTLATAPALNPPPPPKVEGHGVMHSIGSFFKRIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0B8</accession>
    <name>E8X0B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3079</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3079"/>
    <dbReference type="EnsemblBacteria" id="ADW70099">
        <property type="protein sequence ID" value="ADW70099"/>
        <property type="gene ID" value="AciX9_3079"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3079"/>
    <dbReference type="HOGENOM" id="CLU_3099377_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="51" mass="5496" checksum="36794252F603A2C0" modified="2011-04-05" version="1">MSKLLFLVSGLAFAAAYFVVSNQKQAALNTAPVSDLAHKLQDAWADHHTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E5</accession>
    <name>E8X0E5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0739</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579135.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0739"/>
    <dbReference type="EnsemblBacteria" id="ADW67809">
        <property type="protein sequence ID" value="ADW67809"/>
        <property type="gene ID" value="AciX9_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0739"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079080_0_0_0"/>
    <dbReference type="OMA" id="CHKETRE"/>
    <dbReference type="OrthoDB" id="1313887at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017801">
        <property type="entry name" value="DUF3738"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12543">
        <property type="entry name" value="DUF3738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03435">
        <property type="entry name" value="Soli_TIGR03435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233556" evidence="1">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="261" mass="28419" checksum="0E84EE72CBDA3898" modified="2011-04-05" version="1">MSNQSASLRRRLLLLLAAMFAAGTLSAHAQSTPTFEVATIKPAAPNTDGHTHINYPPGGLFSASNITLLALMQWAWDMPQKQILEGPSWLATTRFDLSAKFIPTEIPADPTHPPLSPQDLKRRMVQSLLAERCNLKLHPETRTLPAYDLILAKGGSKLQPSKANGKNFSIGSTHFDGEGLPVDLIAEQISHLVGRIVVDKTGLPDRYDLKLRWTPDDAPPAENAPPTLFTAIEEQLGLKLEPAKEAVPVLVIDHIDLPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0F0</accession>
    <name>E8X0F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0744</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579140.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0744"/>
    <dbReference type="EnsemblBacteria" id="ADW67814">
        <property type="protein sequence ID" value="ADW67814"/>
        <property type="gene ID" value="AciX9_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0744"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_0"/>
    <dbReference type="OMA" id="DFGCYGA"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234038" evidence="1">
        <location>
            <begin position="26"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="171"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="374" mass="40386" checksum="8A8D0745F56A9975" modified="2011-04-05" version="1">MFKRISIPLTLAAATLLSNPAPATAQSDAKPVRVAIIGLVHGHVMGLFSALPKNTNVQLVGIVESDKALSQKYAARYHLAQNLFYTSSEPMFAATHPDAVLVYSTIKDHRKIIEDAASHNVSSMVEKPLATTLEDALAIRAAARAHHVQVLTNYETTWYASNTEALNEAASGKLGTIRKVVVHDGHEGPKEIGVGPEWLPWLTDPIQNGAGALFDFGCYGADMVTVMMHGQAPLSVTAVTQTDKPGIYPHVDDDATVILRYPGAQAVLMPSWDWSFARKDMEVYGMDGYAITVASDGMRVRYKGEKEEARTTAPALPQERSNSLDYLAAAIRGQIKPGDDMTSLPTNMVVVQILAAARESARTGKTIDLKPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J7</accession>
    <name>E8X0J7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0793</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579186.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67861">
        <property type="protein sequence ID" value="ADW67861"/>
        <property type="gene ID" value="AciX9_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0793"/>
    <dbReference type="HOGENOM" id="CLU_1169355_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234236" evidence="1">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="26031" checksum="FF70DC9565B2FB5C" modified="2011-04-05" version="1">MRPQILLTLLLTTAAFPQARPTTFLLEDTTIVAGTAGQFEPSQHQYCLAALKAGTPACLVFSTALFGDTNRYLTLLPIANFAHFDSGQYAASGLTVEEDHAQTGSPAAQTHQSVIALEPELSFTHAPNNQRPLNLFLEYHLRPGTLDAFLALVRSNQLPAARKAAVPAFEVFRTLVGASPDRVFVVYRLDSYAQLDRYKEPDSGEWRDFASKDILSSTSFVVRYRPEISANPNDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L6</accession>
    <name>E8X0L6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1921</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580286.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1921"/>
    <dbReference type="EnsemblBacteria" id="ADW68967">
        <property type="protein sequence ID" value="ADW68967"/>
        <property type="gene ID" value="AciX9_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1921"/>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2422823_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="10338" checksum="402E23D806282219" modified="2011-04-05" version="1">MASTVQIGIHLPVQRQTDQFDWHGCKAVQFDPEKLGGRATVGTTRMDADGIFLNFEDGLSIDELHHHFDSDKEAIREILEFAKSRGYKAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U5</accession>
    <name>E8X0U5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FRG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581443.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3113"/>
    <dbReference type="EnsemblBacteria" id="ADW70129">
        <property type="protein sequence ID" value="ADW70129"/>
        <property type="gene ID" value="AciX9_3113"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3113"/>
    <dbReference type="eggNOG" id="ENOG5032DH4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050026_3_1_0"/>
    <dbReference type="OMA" id="PNLDACD"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014966">
        <property type="entry name" value="FRG-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08867">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00901">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FRG" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="28474" checksum="C268746E9B526695" modified="2011-04-05" version="1">MVDITSSLWTDFLGQIREAKNQLGAPETLWYRGHPNSKFYLLASLLRYKNGLDKEQQLFGDFKRFSDRILRRKESDWETLFDMQHYGVPTRLLDWSETFGVALFFAATYNQSHHPSADAAIYLLDPIALNRLSGISSIYHVPRDEAKFDYRKIYWDHNPFAPIAPIAIEPLFSNDRMLAQRGMFTVHHDKIDPLEDAFPTAIKKVVIPNALIPACLEFLELSNLNMFSVFPDLAGLADYLANTSGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0V3</accession>
    <name>E8X0V3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581451.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3121"/>
    <dbReference type="EnsemblBacteria" id="ADW70137">
        <property type="protein sequence ID" value="ADW70137"/>
        <property type="gene ID" value="AciX9_3121"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3121"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011527_2_0_0"/>
    <dbReference type="OMA" id="EGAYCFQ"/>
    <dbReference type="OrthoDB" id="424805at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230146" evidence="2">
        <location>
            <begin position="22"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="549" mass="60396" checksum="9AA977676D9BFDC9" modified="2011-04-05" version="1">MTIRSLALYACIAAIPCVSLAQQQHHHSGEGISQEALVKVGTVHFPISCSAHVQIPFERGVAMLHSFWYEEARKQFAAVASSDPSCAMAQWGLAMTEWRPFWDGMPEERRKAGIEEIDKAASLDPKTDRERRYIAALRDYLHSDPTQNVVAVRKYADAMGELHTADPSDVEAFAFYGLGLSAAASLDPKDPIASDREALAVLMPGFKAHPDHPGFAHYIIHTCDNPQLAREALPAAEKYAAIAPASAHALHMPGHIFARLGMWKEDIAVNRASVRASELAAKEHLDGVSHEMHAYEFLLYAYLQEGDDTHAREIVQDVSPMIRHLAAIPGIQNDGMYLFTSYMQVEFPSIYHLERHEWNDVLAIAEPAHPLVSSRYFLFWAQAIAAGHLRDASAADQALANAQSIYKAVAAEGSPISAEIHATFLTMKAWQDYAHHRDAEALAQLSASADEQDRVGQAEVDIPAREMYADMLLADGRPAEALNEYKIALHLSPNRFNGLAGAARAAAEVGHLDEARTFYGSLLRLTDDGHASGRPEVSRAKAFLNQQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X114</accession>
    <name>E8X114_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0812</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579205.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0812"/>
    <dbReference type="EnsemblBacteria" id="ADW67880">
        <property type="protein sequence ID" value="ADW67880"/>
        <property type="gene ID" value="AciX9_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0812"/>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106694_0_1_0"/>
    <dbReference type="OMA" id="FDFHYHG"/>
    <dbReference type="OrthoDB" id="1232828at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="191" mass="20425" checksum="28DE7BFBCCCC22A5" modified="2011-04-05" version="1">MNPQEALTRARNIKLLLFDVDGVLTNGDITVHPTGDGTFTEIKSFSAHDGLGIAFARLVGLRTGIITKRHTQAVAIRTRDLKMEFIYQGQHHKPSALYDIQAKTGLALTQIAYVGDDIVDLPVLRLCGLAIATANARPQVKAAAHYITPNPGGQGAGRDAIDFILTAQGTLDQAIEQYLAESTPIAGPGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X190</accession>
    <name>E8X190_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1999</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580363.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1999"/>
    <dbReference type="EnsemblBacteria" id="ADW69044">
        <property type="protein sequence ID" value="ADW69044"/>
        <property type="gene ID" value="AciX9_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1999"/>
    <dbReference type="HOGENOM" id="CLU_2825087_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="66" mass="7099" checksum="E4137DE8092FFB5D" modified="2011-04-05" version="1">MIGPTFQSLKIVTFALLMLGAVGSSLFALGARISKPKQAEPKEQFIPSNVIPFHDARAKTASKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1I8</accession>
    <name>E8X1I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3212</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3212"/>
    <dbReference type="EnsemblBacteria" id="ADW70223">
        <property type="protein sequence ID" value="ADW70223"/>
        <property type="gene ID" value="AciX9_3212"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3212"/>
    <dbReference type="eggNOG" id="COG3230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085041_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="18418" checksum="46E12A0F50C25B75" modified="2011-04-05" version="1">MRMGLGRSEYVFCLQRLHGVVAAWEKAATGHVGDAIRPEWLRSVVKQRLRRPMLERDLAHFNVMNVGAGGPVLPEFQSISSLLGAMYVMEGSTLGGQLIGRHVDRVLGLVDGEGSAYFHGHRELTGSMWREFCGVLEAEIPETDGDATVAAAKAMFQMFGAWMQGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M2</accession>
    <name>E8X1M2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0873</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579266.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0873"/>
    <dbReference type="EnsemblBacteria" id="ADW67941">
        <property type="protein sequence ID" value="ADW67941"/>
        <property type="gene ID" value="AciX9_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0873"/>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_0_0"/>
    <dbReference type="OMA" id="KSVDCRY"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="262"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="35629" checksum="2A23A347D8F6FDE7" modified="2011-04-05" version="1">MKIVIAGGAGQIGTVLARHFHQAGHTVIVLSRTPRSTPWCTLEWDGKTLGPWAAALNEADVCINLAGRSVNCRYNATNRRAILDSRVDSTLALHQAIALVPNPPTVWLNAATATIYRHALDRPMDELTGELGGNEPGAPDTWNFSIAVAKAWEQAFFATPTPHTRKVALRSAMTFSPDPGGVFDVFLALVRHGLGGTNLPGTQFVSWIHETDFIRAIEFLIAHADLSGPINLASPNPLPNRDFLRILRRTWGTRLGLPTTRWMLELGTFLLRTESELVLKSRQVIPTRLLEAGFQFTYPTWPQAAQELVARWRTQHHASRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1T7</accession>
    <name>E8X1T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579330.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0939"/>
    <dbReference type="EnsemblBacteria" id="ADW68006">
        <property type="protein sequence ID" value="ADW68006"/>
        <property type="gene ID" value="AciX9_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0939"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_3_0"/>
    <dbReference type="OMA" id="GYQYGMA"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="127" mass="13282" checksum="DE1780EE3FF87C67" modified="2011-04-05" version="1">MATAQVTPEVVEAPPVAPATPVKMTDAAIGKVKEIMATQDPIPAGLRIGVVGGGCSGFQYSMSFENQSGMMDKVLRFADLKVFVDATSAMYLNGCVVDYVETLEAAGFKFENPTVKSTCGCGSSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V4</accession>
    <name>E8X1V4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580432.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2070"/>
    <dbReference type="EnsemblBacteria" id="ADW69115">
        <property type="protein sequence ID" value="ADW69115"/>
        <property type="gene ID" value="AciX9_2070"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2070"/>
    <dbReference type="eggNOG" id="COG3265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_4_0_0"/>
    <dbReference type="OMA" id="ENFIQVS"/>
    <dbReference type="OrthoDB" id="1843451at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="18122" checksum="C9FD9DD6F06B0E31" modified="2011-04-05" version="1">MIVVLMGVSGSGKTTIGTVLAGKAGATFADADDYHPAANKQKMAAGHPLNDEDRQPWLETLNRLMVGWFEAGASGVLACSALKDKYRKTLSAGMPAGAVHFVLLDGSKEMIAERLAARHHEYMNPALLESQFATLETPGEDDPSAFKVVNDKAPDDVADEILRRIGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X206</accession>
    <name>E8X206_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase FAD/NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2123</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580483.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2123"/>
    <dbReference type="EnsemblBacteria" id="ADW69167">
        <property type="protein sequence ID" value="ADW69167"/>
        <property type="gene ID" value="AciX9_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2123"/>
    <dbReference type="eggNOG" id="COG0369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_7_0"/>
    <dbReference type="OMA" id="WLFFGHQ"/>
    <dbReference type="OrthoDB" id="707164at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="44033" checksum="3814A78D8AA2B97A" modified="2011-04-05" version="1">MSETLEATTESAAAPAAHAPKYTRNNPYQSNVLVNELLTAEGSEKETRHVELSLEDGMTYTPGDAVGILPENRREVVDEMLQALGFTGSERVLDHYKVEIDLDEALRTRLAIGKLERGRITQMVKLAPENAGLKAMAGADNKARAEEYCYGREFIDLVKDFPGIITQPQQLFQILARLTPRMYSIASSQALHADNVQTTVRVVRYDAHGRSRQGLASGHLGERAPVGGTMPIFLHANGNFRLPEDSSKPVIMVGPGTGVAPFRAFLEERQAKGETGDNWLFFGEQRRALDFLYQEQFEGMHKDGVLTRLETAFSRDQAKKIYVQDRIEEHAAEVYAWLERGAYFYVCGDATRMAKDVHTALLDAIAKGSNGTLEHAEEYLATMKKQKRYQLDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X230</accession>
    <name>E8X230_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581585.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3262"/>
    <dbReference type="EnsemblBacteria" id="ADW70273">
        <property type="protein sequence ID" value="ADW70273"/>
        <property type="gene ID" value="AciX9_3262"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3262"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2259816_0_0_0"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11829" checksum="5CAB180C94855588" modified="2011-04-05" version="1">MKALLFSRRAEADFHEISEYLGFLPARPSLRIAEEIQRAFNLIVQFPYLGQAHSRFTTLHGQEVRSLLVASYRIYYFSTSPPEIIAILHGARDQTAIMSQRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X242</accession>
    <name>E8X242_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3274</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581597.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3274"/>
    <dbReference type="EnsemblBacteria" id="ADW70285">
        <property type="protein sequence ID" value="ADW70285"/>
        <property type="gene ID" value="AciX9_3274"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3274"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_0"/>
    <dbReference type="OMA" id="GYGTMQL"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="30738" checksum="C049BD954CD4FFC7" modified="2011-04-05" version="1">MTTVAKTFKLGGDLEVNRLGFGAMRITGEGVWGPPKDPESAKMVLKRAVELGVNLIDTADAYGPDVSEQLIGDALAPYAKGVVIATKGGLTRQGPNKWLPVGRPEYLTQQVEMSLRFLKTDVIDLWQLHRIDAKVPVEESLGAIKKLQKAGKIKHVGLSEVKPHEIDQARKVIDIVSVQNQYNIGDRKHEDVVEYCTKHGIAFIPWYPVAAGELAKPGGKLDEAAKKHGASVSQLSLAWLLHHSPVILPIPGTSSIAHLEENVKASELSLSDAEWAEIESAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U7</accession>
    <name>E8X2U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_3387</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3387"/>
    <dbReference type="EnsemblBacteria" id="ADW70394">
        <property type="protein sequence ID" value="ADW70394"/>
        <property type="gene ID" value="AciX9_3387"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3387"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025132_0_0_0"/>
    <dbReference type="OMA" id="YQIATHI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="116"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="678" mass="72823" checksum="8CA38999403A178E" modified="2011-04-05" version="1">MNAKNARILTVLAVVVLLAAMVGQIVHAIKGESLTWDEGDHIFAGYESWKAHDYSLNPEHPPMVKMVATLPLLGLNLKVAPQQGRFFKTEAYLGGRELLFRNGPANGGQYLGRDLILRVRLFAMVFTVIAALLVFSAGTEMFGVGAGLMGLALFCFEPNLLAHGAYVTTDMAASCTFFATCYAFWRWTVRQTAGRLAVVGVAAGLALAAKHSTVLLAPMLVVLAVGIVVVRWRTNDAKLPGVGRLAAGLVGIVLIAVGVLWAFYGFRFGMRPGGVPMSPSLTEYVGPLAGVEARGILLAAKLRLLPESWLFGLADVRAMANGMPSYFFGRVYAHGVWFYFPVLFTIKSTLGMLGLLVLTVVAMVRGWVKNGLALWFLIAPPAVYLVVAMDSHLNIGARHILPVWVFCCVLAGGGSAALARRGRAGAWVVGVLLFLHAASTVHAAPNYISYANEGWGGPTHTYRYLTDSNTDWAQQLVATSEYLRQHGVTHCNMAYFAAPLILPSDYGVPCKQMPTYDSLSNPSVAAAVEIPGVIDTAVDGPVLISAGDLNGFEFGTSVMNPYEGFRSVKPVAFIQDGIFVYEGRFAVPLASALAHAQRSMVMMEAKDPAGALKEAQTAERTAPGAVQVEMQLGDVEAAAGDKAAARDAYGRMSGQIETMEPDAREQWRTTVKDKMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2W0</accession>
    <name>E8X2W0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1031</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579417.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68094">
        <property type="protein sequence ID" value="ADW68094"/>
        <property type="gene ID" value="AciX9_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1031"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459363_0_0_0"/>
    <dbReference type="OMA" id="GRTMERH"/>
    <dbReference type="OrthoDB" id="1939146at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="181" mass="20743" checksum="0C1070AC62C7B60F" modified="2011-04-05" version="1">MADDPTNVAVPLQQYLETAYRPDRDWIAGEVRERHVGEQSHASVQGFLTQIFRNRGIEWQIRAFPEQRVQTSKEHFLIADLCVVSRTVPLEPVVRTAPLLCVEILSREDKMSEIQLRVDDYLQMGATAVWVIDPRRRDAHLARAGRTMERHWEKLIVPGTPIVITLAEMFSELDELEGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2X4</accession>
    <name>E8X2X4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Collagen triple helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1045</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579431.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1045"/>
    <dbReference type="EnsemblBacteria" id="ADW68108">
        <property type="protein sequence ID" value="ADW68108"/>
        <property type="gene ID" value="AciX9_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1045"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945828_0_0_0"/>
    <dbReference type="OrthoDB" id="979816at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="294" mass="28908" checksum="0DC6E6E83ACD013D" modified="2011-04-05" version="1">MRRMGWGCWLGLLVVLFVVGSRAAHGAQATLVADAHVNAARPAVNSGAISNVNVGGGYTGLFQFDLSLLPVGTTSAQISRAVLRLYVNQVTTGGLVSLQPLTSGWAEYGVTYQTVPGMGSAAQVFTVSQAGAYVAVDVTALVQGWVSAPVTNFGFALTAGTAAVQFDSKENDLTAHGAALEIGIVSQGPQGIQGVAGSVGPAGPVGLQGLAGVAGPQGLPGVAGVAGPVGAIGPVGPAGVAGAQGVAGPSGPVGGVGPVGAAGAPGLVYQGAYGSTTTMRWGMLWCFRGRAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2Y4</accession>
    <name>E8X2Y4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Nicotinate phosphoribosyltransferase</fullName>
            <shortName evidence="8">NAPRTase</shortName>
            <ecNumber evidence="4 8 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pncB</name>
        <name evidence="12" type="ordered locus">AciX9_1055</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579441.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1055"/>
    <dbReference type="EnsemblBacteria" id="ADW68118">
        <property type="protein sequence ID" value="ADW68118"/>
        <property type="gene ID" value="AciX9_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1055"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_1_0_0"/>
    <dbReference type="OMA" id="QAVFHRY"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="11">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="10">
        <location>
            <begin position="197"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="50279" checksum="F2A6B62F9D1C11F3" modified="2011-04-05" version="1">MNVNFAERAHNHNWKLDPIVRSLLDTDFYKLLMLQFIWKNFPQVQVTSEVVNRTVRVHLAERVGMAALREQMEHVRGLRFRRSELVWLAGNTFYGVRFIFEPAFLEWLEKDFALSDYEIAEQESDDPAHAGQLTLRFSGLWTAVTMWEVYALAIVSELKTRAALAELSELELDVLYARAKTRLWDKIEKLRDVEGLQLSDFGTRRRHSFLWQEYAVQALRASLGKRFGGTSNTALAYKHDLEAIGTNAHELPMAMAALASVGSDDELRASQYRVLELWQRSYGGSLLIMLPDTFGTTQFLEHAPEFAADWTGQRVDSKDPYVAGDEYVAWLESRGRDPRQKRLIASDGLDVDDIVKLHEYFSGRIRFSAGWGTLLTNDFRGCHPRGEDTLEPLSLVCKLTSANGIPTVKLSDNARKTAGPVELVARYRRVFGSEAETGAAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X377</accession>
    <name>E8X377_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="6" type="ordered locus">AciX9_2263</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580617.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2263"/>
    <dbReference type="EnsemblBacteria" id="ADW69301">
        <property type="protein sequence ID" value="ADW69301"/>
        <property type="gene ID" value="AciX9_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2263"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_0"/>
    <dbReference type="OMA" id="TRNPATM"/>
    <dbReference type="OrthoDB" id="1100044at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="79"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="34947" checksum="4B29DC474304D150" modified="2011-04-05" version="1">MATLTMIEQVEPERPEKHSGIRDLRPFSGLTTESLNAASHDLDTKSALEIARIINQEDAKIAAAVKKALPEIAIVIDTVARSLRDGGRLIYVGAGSSGRISSLDASECPPTFSTAPSQVQYIMAGGPKALASASDVNEDSPEIGQRDIARRRPTRKDIVIGVSASGRTPYVVGAVEYARARGAKTACVTCNIGTPLADVSDTSIVTEVGPEVISGSTRMKASTSQKMILNMITTGAMTRLGYVYDNLMVNVHMKNAKLVERGIRVLMDVCHIDRDTAIRTIKSAGKSIPIAMVMLKANVDKMEAVRRLGKSDGNVRLAIDDSRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A7</accession>
    <name>E8X3A7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3402</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581720.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3402"/>
    <dbReference type="EnsemblBacteria" id="ADW70408">
        <property type="protein sequence ID" value="ADW70408"/>
        <property type="gene ID" value="AciX9_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3402"/>
    <dbReference type="eggNOG" id="COG3657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152445_1_0_0"/>
    <dbReference type="OMA" id="EYMATAK"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014056">
        <property type="entry name" value="Addiction_killer_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41791">
        <property type="entry name" value="PTHR41791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028744">
        <property type="entry name" value="Addict_mod_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02683">
        <property type="entry name" value="upstrm_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10838" checksum="EBD610F570DB0CA1" modified="2011-04-05" version="1">MCHAEDGSVPFQEWLFDSLDVRTRARITVRIDRIEDGNFGDVKPVGEGVSELRVDFGPGYRVYFGQKGNEVHLIRGGSKGTQTADIAAAKDFWRKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3J3</accession>
    <name>E8X3J3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579507.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68184">
        <property type="protein sequence ID" value="ADW68184"/>
        <property type="gene ID" value="AciX9_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1121"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_4_0"/>
    <dbReference type="OMA" id="FMATVHG"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="191" mass="21125" checksum="D0F9ACF9D4A06E9A" modified="2011-04-05" version="1">MKMPNSTADKILDTAHALIADRGYAAFSYADISSEVKVSKATIHHHFPSKEILVVSVLRQHRHRLGEGIASLNDAVANPLERLKAYMSHWESCIEKKTEPFCIAALLGAELPSLPSEVAAEVRLHFVDLHRWLQQTLEAGAKQKSIHLTQTASDEAEFMMATVHGAMISARAYQSPKVFAQIVNATLQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3P2</accession>
    <name>E8X3P2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2282</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69320">
        <property type="protein sequence ID" value="ADW69320"/>
        <property type="gene ID" value="AciX9_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2282"/>
    <dbReference type="HOGENOM" id="CLU_215851_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="49" mass="4773" checksum="23BF257F4FD5F3BF" modified="2011-04-05" version="1">MTVDGGLKPPSNPNGNGNGNGNGNGNGNGNGKSNGKSKSNYGDSPLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R9</accession>
    <name>E8X3R9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580663.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2310"/>
    <dbReference type="EnsemblBacteria" id="ADW69347">
        <property type="protein sequence ID" value="ADW69347"/>
        <property type="gene ID" value="AciX9_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2310"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234336" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1257" mass="134087" checksum="C7C0CA580769315D" modified="2011-04-05" version="1">MQTFCLRSGRRILLGLALALASSSLLSAQTNTTALSGTVTDASGALMPGVAISISNPASGSVQNTSTHSKGEFSFDQIPPGTYVVKVLAPGFSEQDEQVELLVATPVKMDFKLTVGTSEVVNVETNIAALNATDASLGKAFDSKQIQNLPYLANNITYLLSLQPGVLALDSGAQTGGLNTDTRTGIVNGARQDQTNISLDGVDNNDQTNGYAFNGALRATRESVEEFRVTTTGSNADAGRSSGGQVSLVTRSGTNTYHGSAYEYYRGGIGLQNNWFNKQTQLNTNTGNVPLKVLQNTYGASFGAPIIRDKLFFFAAYEGFKQASDQQVAATVPSLFSASGTAQGLVTGNVTYQVCPSSVVCKSSTATKTLTPTDIATLDGRANDPVCSTSACTAPTTNAAAIAYMKQFPLANNNTGGDGFNTGTYSFASPLPLHQITNIARVDYTINPRQTLFVRGNLQSDNQAAALTFPGLLAASNTFGNNKGMAAGHIWNLNSAMSNNFRYGFIRQGTATRGTGSQPYVTFSAFTTISATTTSTIYKITTNNFADDFTITKGRHTIQFGVNDRLLSNSRYFDSPLLSNASVTSSLLALAAVANTGSSYDPAIGTCADCGTVSSGFANSYNAAILANGGVIESGKSGTEYLVQNGSLVPAGAGVVPTHIYHNLEQEYYIQDQWKASPRFTVTAGLRYNYYGVPYEIHGQQIAPTIAANTLLQNRVAGANSGTSYNTPISFAVSGSANNAPNFWTPQKGNFAPRISFAYATPDNRTSIRGGFSLVFDHFGEGVVDYYDAGTSSLLSLSKSNTFSYTDVNTNPRFTGYHNVPLGTVTVATTALPATPANNEFTFLKTVNSIQKTPYAEAFNFTIQREVTHGLTLTGSYVGRLGRHLSDAIDVAQPNNLLDTASQQTYFQAATAYDKMIDAGVATNTVANTGYFQNLFPKAAYKGFTGAQAFYAFMAANRGNETAALYQFDYTAGAASSPAGQSNRFFYPQTSSIYVQSTIANSNYNALQMSARHVLRYGLEYDLNYTYSKSLDQGSSPERSASNYIVNTVNPSQMYAPSDFDVRHNITANYNAPLPFGKGKPFLGHANGLVDRLIGGWQLNGVVHYSTAFPFSASISNGFGTNFDSSSNYIQTGPIPTGGHHYVPGGNYETALNGITVTQAFANLRAAYVGETGQRNNFRADGYFSMDDGFSKSFRTFREQAFKIQVEVFNVTGSTRFNALTATGNSTKFGQYTGGSATTTGLLGQPRQMQFSGKYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X459</accession>
    <name>E8X459_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ordered locus">AciX9_0028</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0028"/>
    <dbReference type="EnsemblBacteria" id="ADW67119">
        <property type="protein sequence ID" value="ADW67119"/>
        <property type="gene ID" value="AciX9_0028"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0028"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_0"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="16911" checksum="8BE4A13D3D8F1F9B" modified="2011-04-05" version="1">MPLVGVVMGSRSDYAVMKAAVDVLREFGVPYEAKVVSAHRTPELMVEYAQTAIARGLRVIIAGAGGAAHLPGMIAALTVVPVLGVPVSATSLQGLDALLSIVQMPKGVPVGTLAIGASGAANAGLLAVAMLATTDAELQQKLIARREATRDKVLGESLEEDEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X485</accession>
    <name>E8X485_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_0054</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578474.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0054"/>
    <dbReference type="EnsemblBacteria" id="ADW67145">
        <property type="protein sequence ID" value="ADW67145"/>
        <property type="gene ID" value="AciX9_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0054"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="IQKYPAT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="43510" checksum="8CF39D25915603CD" modified="2011-04-05" version="1">MEIKEALKLALQSLWANKMRSVLTLLGVVIGVASVIAVVTLVNGANMFVIQKFSRYGADVFTISRQPAVITNVDDFVKFAKRKNILFADYKYVEENCRRCAGMGAQQATSGKLVRGTQAITDAQIRGYTWQMPQLQNLDITEGRGLTDTDEEHASHVAIIGTDVEENLFAGVDPIGQELRVDGSPYTVVGVTEKQGSTFGQSQDNFVGVPLTTYQKSYGTQKTVTIYVKAGSAGPPLEEAADEVRVLMRAQRHDAPGTPNDFELDTNNTLVGFAQQITGSFGVVAGAIALISLVVGGIVIMNIMLVSVTERTREIGIRKALGARRTDILLQFLIESALLALAGGAIGVLGGVVVAEAVTVFAGFPSTVAVWSVFAGLFMALSTGLFFGVYPARKAAELDPIVALRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4C1</accession>
    <name>E8X4C1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1185</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579571.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1185"/>
    <dbReference type="EnsemblBacteria" id="ADW68248">
        <property type="protein sequence ID" value="ADW68248"/>
        <property type="gene ID" value="AciX9_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1185"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_0"/>
    <dbReference type="OMA" id="NWNKQLT"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005932">
        <property type="entry name" value="RocA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01237">
        <property type="entry name" value="D1pyr5carbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="60"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="542" mass="57956" checksum="4CE90ECC808497AF" modified="2011-04-05" version="1">MNTAASAPSLASLSTFVNEPFLDFADADVKRSMEAALAEVKGELGREYDLVIGGQRLRTAEKITSINPARPAQVVGVHQMAEAEHAEPAVKAALKAFETWSRLPVAERVELLLKVSKIISERKYQLCAWLTFEVGKNWAEADADVAECIDFMEFYAREALRLDGSTTPIQFPGEKNVLKYVPLGVGAVIPPWNFPFAIMAGMTAAAIVTGNTVVLKPSVDATTIAAVFFGILEEAGLPAGVVNFCPGAGPGFGSTVVAHPQTRFVAFTGSKKVGLEIHESAAKTQPGQRFIKRTILEMGGKDAIIVDGDCDIDMAVDGVLASAFGFSGQKCSACSRAIVDAEIYDVFCDRLVEKVEKIKQGDPAENFYAGPVISPLAYKRVLDYIEIGKGEGRLLTGGEAVANEGGYYVAPTVFADVLPTARIALEEIFGPVLAVIKYESFDEALEIANNTEYGLTGAIYSGSREKLERAREEFHVGNLYLNRKCTGAMVGAHPFGGFNMSGTDSKAGGPDYLLLFTQGKSVAEKVGHVSPAADLQEEGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H0</accession>
    <name>E8X4H0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1234</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579620.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1234"/>
    <dbReference type="EnsemblBacteria" id="ADW68297">
        <property type="protein sequence ID" value="ADW68297"/>
        <property type="gene ID" value="AciX9_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1234"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="KKMPIDA"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="306"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="412" mass="43774" checksum="C900C9E0502F79E3" modified="2011-04-05" version="1">MLTDIWGQAVEAMKHNRRRTITTVVGMAWGIATVVLLLAFGAGFGHAIEAIFAQFGTNEIGVFPGRTSEQAGGAKAGVAVRLTIEDVERIQESVGGVILVSPFVAKTVPVSNELHSYSWEVDGIKPELQTIQKLDVADGRQLTEGDVETRAHVAMIGSEAKTKLFGGREAVGETIRLNGVSFQVVGVQVAKMQEGDSDINRGINVPFSTIGDIKDTKYIDGVWFSYHGDFEATEKAARETLATAHGFRASDHNAIYVANLMKQLSQFRLISLGLQVLLSFIGALTLGIAGVGLMNIMLVSVQQRTKEIGIEKALGARRRHILLQFLAEAMAITGVGGLLGIGIAYFVSLAAGSIPFYSALASNATDADIHLTISPGSLGVAVGILAVVGVISGMVPAMKAARMDPIEALRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P3</accession>
    <name>E8X4P3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2416"/>
    <dbReference type="EnsemblBacteria" id="ADW69453">
        <property type="protein sequence ID" value="ADW69453"/>
        <property type="gene ID" value="AciX9_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2416"/>
    <dbReference type="eggNOG" id="COG5336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183496_0_0_0"/>
    <dbReference type="OMA" id="FIQIFRT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="85" mass="8683" checksum="8ADEC6B844E3B12B" modified="2011-04-05" version="1">MGDNGSMAGKGTGGGGGLGDLVKAESMIQLAIALPLGCVIGWLLGAALDKHFHQNWMGIVGILLGAVGGFIQIFTTAQKFLKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4P6</accession>
    <name>E8X4P6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2419</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580772.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2419"/>
    <dbReference type="EnsemblBacteria" id="ADW69456">
        <property type="protein sequence ID" value="ADW69456"/>
        <property type="gene ID" value="AciX9_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2419"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_0"/>
    <dbReference type="OMA" id="NHIWDKK"/>
    <dbReference type="OrthoDB" id="1127353at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="29340" checksum="F770B9A16C906A45" modified="2011-04-05" version="1">MNILFVGDIFGSAGRHIVREHLPHVLETNAVDLLVINGENAAGGFGITPSLAEEIFDLGAHVITTGNHIWDKREIFEYMKVPVESHERGRRILRPANYAVGTPGFGHYEGTLADGTKYAVINMQGRVFMNSCDDPFRKADELLTRIERGSNAKVILVDFHAEATSEKVALGWYLDGRVTAVLGTHTHVPTADQRILHNGTAYQTDVGMSGPYDSVIGVEKELVLQKFLTGMPGKFEAAKGNPKMAAALIECDPVTGRAYQIQRLLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q5</accession>
    <name>E8X4Q5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ordered locus">AciX9_3539</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581855.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3539"/>
    <dbReference type="EnsemblBacteria" id="ADW70544">
        <property type="protein sequence ID" value="ADW70544"/>
        <property type="gene ID" value="AciX9_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3539"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_0"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW70544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="8970" checksum="643552E88A717515" modified="2011-04-05" version="1">MAAVDEKVKQIIVEQLQVDEAEVTPGASFQEDLGADSLDVVELVMQFEEAFDIQIPDEDAEKIKTVKDAVDYIEKNQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4R5</accession>
    <name>E8X4R5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70554">
        <property type="protein sequence ID" value="ADW70554"/>
        <property type="gene ID" value="AciX9_3550"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3550"/>
    <dbReference type="HOGENOM" id="CLU_2861460_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233675" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="6843" checksum="6C5F933A7D408536" modified="2011-04-05" version="1">MKTAITRKVGNKFGKLMVAGALMLSPALALAHPGTPETRIHTSPVHEHGVQIHSVHSSTIVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y3</accession>
    <name>E8X4Y3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0085</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578504.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0085"/>
    <dbReference type="EnsemblBacteria" id="ADW67175">
        <property type="protein sequence ID" value="ADW67175"/>
        <property type="gene ID" value="AciX9_0085"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0085"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_0"/>
    <dbReference type="OMA" id="PIANEHE"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="304" mass="34380" checksum="FADA3028AA395F94" modified="2011-04-05" version="1">MNFEPFLEFYKNIKKVSDDTLAAYRSDLKHFGLFLATEHVDRITQIDHALIAKFITYMKISGKGKGGKVGLSDATIARRLAAVSSFFDYTRATTGRKLHNPIEDFSNRWKRNNKPKPVEEVVLEKLLSAITSPRDRVLINLFLATGLRLGEMEQLNRDTIVIEQHKGNGPNECFVIGTGEVEGKGGKIRTFMVSQQALIPYARYVNGRKDDHPALFISERKQRMSERAMQERLAHWCKVAGVSHTNVHRLRHTYGTRLVNAGMDILQLKELMGHSSVATTLNYAKIMDTTLARGYHAAMEFVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X515</accession>
    <name>E8X515_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0130</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578535.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0130"/>
    <dbReference type="EnsemblBacteria" id="ADW67207">
        <property type="protein sequence ID" value="ADW67207"/>
        <property type="gene ID" value="AciX9_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0130"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497620_0_0_0"/>
    <dbReference type="OMA" id="IPCDSCF"/>
    <dbReference type="OrthoDB" id="1516378at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="4">
        <location>
            <begin position="484"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="557" mass="62203" checksum="02E2203F3C3276DC" modified="2011-04-05" version="1">MAHASFDGLRVLSLESRRAKEVEKLIRTYGGQPFVVPFMREVKLESNHAALDFADRLMRGELDVVIFMTGVGVRALLEIVETRYSRTEFLEALGRIKIVTRGSKPEAALRELKLRSVATASEPTTWHELMSAMHAYFGDSLKDQRIALQEYGASNPELLAELTECSASVFKVPVYQWALPHDLKPLRECVHGLTHASVDVVLFTTAVQVIHLMLIAQEMNQVAEMLAGLRSVVVVSVGPTTTAELLHYGIPPDFEPSRPKMGFLINEAAQYSAQVLQGKRQRASLPPEEEFEPAPAPGEPLTHVAQSRHAVRRVAESTPTMAGFSDGLSSFDFLHEISRRLAASDPLHTVLDRILEFVTTMIPCDSCFLYTLEGEKLVLRASRNPHADIVDSLGIKLGQGITGWVAEHREPVAIASRASEDPRFSKFKNIPEDTFEAMLCTPIVCATRVIGVINLQHRLSYSHSSVEVRLLSLIGYLVGAEIERARLDTENLQLADRLETRKAIDRAKGLLQRDLSISESDAYRMMQRESRQRRKTMREIAEALLLNEEMKRSTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X527</accession>
    <name>E8X527_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0144</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0144"/>
    <dbReference type="EnsemblBacteria" id="ADW67219">
        <property type="protein sequence ID" value="ADW67219"/>
        <property type="gene ID" value="AciX9_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0144"/>
    <dbReference type="HOGENOM" id="CLU_836166_0_0_0"/>
    <dbReference type="OrthoDB" id="1817117at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="332" mass="36744" checksum="7A0B7BFD6DDB9D2C" modified="2011-04-05" version="1">MIGTNRQNMTSEDGEGLGKIEPRVPMRMGRYIALLGFSAIVLYLLPFVINKMPGYDRRFGTFFGPLLDYGYSANDVNADIVVFGDSSAVFGFDPVQVGNALNLKVINLPNTLGSLAVTQDDVLRGYLKHNKAPRLIVFYFAPWDLDFNAGKPKENLFEGEDILLRTAPASEIITYFRHYPLHLLNYPLEFYSSVVQNSLVTFAHHTSGQAQIVARHGHADVPAHAPSLSEDCSLPTALTNPVGSDTVDRFINSYRSQATQTWLYISPIPNCRNAQLITNRSYRGDLTSSPAALDPTFFALDYTHVRAPGVPQSSEIFTQALTKALKSEPLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X559</accession>
    <name>E8X559_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1261"/>
    <dbReference type="EnsemblBacteria" id="ADW68323">
        <property type="protein sequence ID" value="ADW68323"/>
        <property type="gene ID" value="AciX9_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1261"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_0_1_0"/>
    <dbReference type="OMA" id="TEDCDWV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="143" mass="16088" checksum="D81E21C68CC1A582" modified="2011-04-05" version="1">MLSAADKREIVAVVHGFEDAWAKRDMDAFRAMLTEDCDWVNIVGMHWHGREEVTEMHRVLLEGRYKGVNVHTLSHEESEIAPGVALVVQKSQLDDFTTPDGHLVKGLQNMGIMVLVKRDGKWLIRASENSSIDPRASMKPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X577</accession>
    <name>E8X577_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1279</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579664.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1279"/>
    <dbReference type="EnsemblBacteria" id="ADW68341">
        <property type="protein sequence ID" value="ADW68341"/>
        <property type="gene ID" value="AciX9_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1279"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_0"/>
    <dbReference type="OMA" id="MDEMAFL"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="173" mass="19442" checksum="9BC2AEDF8A9A1B7A" modified="2011-04-05" version="1">MSDEVVLRAVRESQSERSEIIFPGDANALGNLFGGRLMQFMDLTGAMAASRHARAITVTASMDHLDFVAPVHVGDLLILKASVNRAFKTSMEVGVKAMVEDVRKQRLRHVSSAYITFVAVDQNGAGLVVPQLLLETDHQRRRYEDAGRRREMRAGETARRKRLREELTADWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X585</accession>
    <name>E8X585_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1287</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1287"/>
    <dbReference type="EnsemblBacteria" id="ADW68349">
        <property type="protein sequence ID" value="ADW68349"/>
        <property type="gene ID" value="AciX9_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1287"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_1_0"/>
    <dbReference type="OMA" id="QEDPTDA"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="360" mass="39054" checksum="29F4A8273C72E849" modified="2011-04-05" version="1">MATTPQITSPYPPPEGTPPSPSVVERKSAVRSNIVFFFAMILLFVLGYKLLKELEILYVAALFAVVLMPMVIWITERSIRSYKPSRPVAIILLLLSAVVFLGLFFTIAVPPVLTDLRNFLADLPARIPGAVAHLKKLPLADKIGVDQIAAKAEAVAGATGSYIFSALPNWLSHVFDLLTALFLCIYFMLEGEHAYNFFLSIVPLNSRRRLDVTLKKAELKMSKWLFGQGLLMLILGVTSTIVFGVLHVRYFILLGVLMGLLNIIPIAGGVVTILLAAGVAALDSWTKMAGVFIFYAIYANIENAFLTPRIMKSSVDLMGLTVLVALLLGTALAGIVGALVAVPTAALIAVLLEEYAVQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B0</accession>
    <name>E8X5B0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="6" type="ordered locus">AciX9_1312</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579697.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1312"/>
    <dbReference type="EnsemblBacteria" id="ADW68374">
        <property type="protein sequence ID" value="ADW68374"/>
        <property type="gene ID" value="AciX9_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1312"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_0"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="366" mass="39807" checksum="B2264351634114A5" modified="2011-04-05" version="1">MPLNVGIVGLPNVGKSTIFNALTSAEAQAANYPFCTIDPNVGVVQVPDARMDRIVTMVKPDSIVPTTMEFVDIAGIVEGASKGEGLGNQFLSHIRQTDAILHVVRCFADPEVIHVAGGVNPLHDIDIINTELLLADLDTVEKRAVKAEKAAKSQSATAAQKSEHSAIQKLREVLNAGKPARVAELEDDEKLIARDLFLITAKPMLYVANVDESALTTGNEWTDAVEKRAKEEGSEVVRICGQMEADIAQLDAAERQEFLSEMGLTEPGLNRLIHAAYRLLGLYTYFTSGVQEVRAWTIKKGTKAPGAAGVIHSDFERGFIKADAYHCEDLFRLGSEQAVKEAGLLKSEGKEYVVKDGDILFFKFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5B5</accession>
    <name>E8X5B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580778.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2426"/>
    <dbReference type="EnsemblBacteria" id="ADW69462">
        <property type="protein sequence ID" value="ADW69462"/>
        <property type="gene ID" value="AciX9_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2426"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OMA" id="MGEATCH"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="243" mass="26303" checksum="76AC8727AEA7D114" modified="2011-04-05" version="1">MDKLKGKVAVITAATSGMALATAKLFVEEGAYVFITGRRQDKLDEAIKIIGKNVTGVQGDASNLADLDRLYETVKREKGKIDILFASAGFGEFAKLEEVTEEHFDKTFDLNVRGTLFTVQKALPLISDDGSVFLNGSIASIKGFPTFGVYSASKAAIRSFARTWLLELKERRIRVNILSPGTIDTPILDPLGDEAKAFFKSQIPRGEMGRPEEIATVALFLASSDSSFVNGVELFVDGGTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5P7</accession>
    <name>E8X5P7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3673</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581983.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3673"/>
    <dbReference type="EnsemblBacteria" id="ADW70674">
        <property type="protein sequence ID" value="ADW70674"/>
        <property type="gene ID" value="AciX9_3673"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3673"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_0"/>
    <dbReference type="OMA" id="ILYTSQM"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="292" mass="30639" checksum="E206A34B6E04215E" modified="2011-04-05" version="1">MIVVTGATGQLGRQIVEGLLNKLPGTQIGISVRDPEKAEDFKQRGVRICKADFADPAGLAGAFDGAEQILMVSVNKFGEEAVRLAGNAIQAAKKAGAKRILYTSHQGASASSAFVPAQGHAATEALLAASGVPYVSLRNGFYAESALFQLGSLKQAGKISLPEDGPVSWTSRSDLAEAAVAALTQPGLFDGVSPPLTASQTLDFAAIAKLASEILGREIVRETVTDEDYRAGLIAHGLPEMLADGIGSLYKASRADEFAVVDPTLQRLLGRRPTAMTDALSEFLSKPETKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5T7</accession>
    <name>E8X5T7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4025</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572733.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70821">
        <property type="protein sequence ID" value="ADW70821"/>
        <property type="gene ID" value="AciX9_4025"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4025"/>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="WIADEDY"/>
    <dbReference type="OrthoDB" id="991484at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="46047" checksum="E8BD517622D8B6F4" modified="2011-04-05" version="1">MILRDAMISAESTRTRWVPVSEQDHAEVLRALEGVLASPHFCNSKRYPAFLRYVVEQSLLGQADQLKERTIGVEVFGRTPTYDTNTDTVVRYTAGEVRKRLSLHYHEVAETSIQIHLSARSYQPEFLMLDEAGEAAQVEIPVAVVERVQDESRRPLSPGTPVRSGTGLRKWVLPVVMVVVLLLLGGAAWMRLMARHKGDSLHQFWAPVLQANAPVLISPGGVVFSQTSRIGTQVADHDVMNPFLSFENGLAMGRVAALVNGMGGSYTIQSSNATSLAQIRESPVVLIGAYNNAWTQRLLEPLRFHFSAHPGEQIVDGAQPGRHWVRDLARPYSESPDYAIVARFRNPSTDSMVVAVAGLQRYGTDAASQFIISPRSLNTLDARLGPGWADANVEIVLKVDVVNGRVGAPMIEDAYTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V2</accession>
    <name>E8X5V2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Male sterility domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4041</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70836">
        <property type="protein sequence ID" value="ADW70836"/>
        <property type="gene ID" value="AciX9_4041"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4041"/>
    <dbReference type="HOGENOM" id="CLU_042504_2_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:fatty-acyl-CoA reductase (alcohol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="348" mass="38976" checksum="256EF3422530116E" modified="2011-04-05" version="1">MRELLERKPSATLALLIRDTATQSAQQRADAFIPLAERSRVKVFAGDVSQPNCGLDSAAYDRLLAETTRVIHSAATVRFDHTLDEARRTNVEGTRHILDFAGGAHQLRSFAYVGTAYVAGERSGLVREDELVVGQSYRNTYEQTKAEAEALVQSRLASIPGMILRPSIIVGDSKTGVTSSFKMMYWPLKIYARRLWRTVPGYSDAVLDIVPVDFVARSVVQLLFDEAALGCTVHLCAGPLASATIQQVAHRAMEYFNGPEPRFIDPKIFFALVRPLLFLSLWGRKRRVLRDGSAYRDYFTMRMQFDTSNAERLLRPAGVSPPPVLDYLDHLFHYCVASDWGRKSISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X2</accession>
    <name>E8X5X2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572768.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70856">
        <property type="protein sequence ID" value="ADW70856"/>
        <property type="gene ID" value="AciX9_4073"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4073"/>
    <dbReference type="HOGENOM" id="CLU_315625_0_0_0"/>
    <dbReference type="OrthoDB" id="718402at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="fn3_3" evidence="2">
        <location>
            <begin position="593"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-like" evidence="1">
        <location>
            <begin position="682"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="925" mass="97355" checksum="324A928A32052D9F" modified="2011-04-05" version="1">MTASSRSPLSIATRACRKAGLTATIALILATIGCGNNSSRQQALLGPALTLNALTTTSASQTVSLTNIGSVALHVTGVSITGTSAAAFAETDSCKGTLAVGAVCPIAVTFTSTAAGSFTASLNVADDTPYGGQQSVSITGTATVPIPVVALSSTSQAFPLLTAGTISAAQTTTVTNTGTAPLTISSISIGGSGANLFADSTTCAATLAVSASCNIAVTFAPRVAGTYAGTVTLSDNAATPTQSYTLAGTATPAALSIDTTNGADWKVANGALNLDFNPKNGHVFGIFLAGHTDNLVDTTNSNEGIYMDNAGFGAPTPTAAYTQAAGYIDFYVTFPSNATNAYTYTEHFVVTPNDPGIHLYFVANHSATDIAGSIGQVQWVYRSNLTQFPNTYSVNADLSNPGPVVVPLPAASEDFSTDPGRAVQDATVDLHGLPIPTGYTRNFYTKYDYSSYNYLHQAHGTYGSTYGTWAYFPSNESLVGGPTKQNLIYTGNLLILEAYSNHYDNSLSLATPSGTASSRLFGPFYVHFNTFGQAYNATGNILATPDDMYKDTLQAGASFKTFYDSEAQLVAAGYIPSTARGTVSVQVNGVTSTNAKTSWAVLSDPKTNFEYSSHGSQYWADISTSGAATFTGVIPGTYRLSTYVLGQWGESRQENVVVTANQTTTVPTSTFVPENFGTTTPVFTIGTADRSSHEFLHGHDAANHDDREFWGSWNYWADFQANQGAVIYNATAGPAGAATNDLTKWNYTHWGTFYPGLFGGVYSAADDTTDGYKYVVPSYVAAPATMRTPNWQVHFATPATQTGTTAATYVVLSAAIACAEGSYVITLNGQQLIWHETNASDCMVRSGLSAYTQWIAFQWDASVLNPAGQDNLLTLNVSQVDGISDDALRLELTKTSADPAVRNWFDYEYIYKTIDTKPNDAVANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8X642</accession>
    <name>E8X642_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_4146</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
            <plasmid evidence="14">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572838.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70926">
        <property type="protein sequence ID" value="ADW70926"/>
        <property type="gene ID" value="AciX9_4146"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4146"/>
    <dbReference type="HOGENOM" id="CLU_047835_1_1_0"/>
    <dbReference type="OMA" id="QVRPFEF"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="224"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW70926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="341" mass="37860" checksum="2C89EC4A84C6B5A3" modified="2011-04-05" version="1">MNPETDFNQMTGTRKAAILIALLGEETAASIFPHLSEEDLQGLTHEISRLGSVSKDISLQVLEEYQQMTVAQDHIAQGGHDMATRLLNRAFGENGARDMVQRLIRSQEVNSSKVESLQRIDPKQLARFLEGEHPQTIALILGHLETKQASALLMCLPHPVRAESVRRLANLRQFSPAMAEKVAIVLNKRLRSVGEQKKKTYSGFQSVADLMNNIDATTSGEILETIEKEESTLAVSIRDLMFTFDDFLGVSEVQLRTVTSTVDKKVLTLALKGANERLRGHFYSTMSSRAIEMMKEEADLLGPVRSKDVAKAQLDIVAVARKLEMEGKIILKSEGADEYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X666</accession>
    <name>E8X666_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4170</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572862.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70950">
        <property type="protein sequence ID" value="ADW70950"/>
        <property type="gene ID" value="AciX9_4170"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4170"/>
    <dbReference type="HOGENOM" id="CLU_682893_0_0_0"/>
    <dbReference type="OMA" id="CIEHGRW"/>
    <dbReference type="OrthoDB" id="1303616at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="403" mass="43499" checksum="8788BD3B49345770" modified="2011-04-05" version="1">MTNPRAVSLLSIPLALILATGLLSPVHAGPISSEFTYKILKPIESGDLTLFPVVLTNAKASPDDPFLTLDEGLRSGEVEVTEAGRVHGLVRSRSGAHPAIAQPEYRGDQVNTLVLVNHSQRPLLLLAGEIVTGGKQDRIIAKDRIVPIGADPIDLSVFCIEHGRWTESSDKFGTTANSPAQSFMVQPAVRQQAMVARDQQQVWNSVSNSITAMAAAPPAPSAGAIHGQVTILRPDVNVQPLATTSYAKALQSVAVSAKVDEASSNLAHSREQILATLRQQHAIGVVVAVHGDIIWADLFSNTDLLTRYWTKLIRSYAAEGLTTSASDHQTAATLEDAQHFLSRPMHGAENSEGEAGVYRYSEIRTGPTDQFDLESLLPNTPQEVHISRLKLKNSTDHRPALMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6A4</accession>
    <name>E8X6A4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family with LacI sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572900.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70988">
        <property type="protein sequence ID" value="ADW70988"/>
        <property type="gene ID" value="AciX9_4210"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4210"/>
    <dbReference type="HOGENOM" id="CLU_037628_15_0_0"/>
    <dbReference type="OMA" id="DYIFPRI"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="362" mass="40315" checksum="FA0D0525A8E09926" modified="2011-04-05" version="1">MSRHRAIYEELLKEIRSGTYQPGDRLPSEAALCERFDASRITVAKAIQTLQQDRLVMRRPGSGTYVERPEQVASMQFGLLIPDLGTTEIFEPICQGLMRSPVAKAHSLTWGHSDPGVQNPEVVADQLCQQYIAQRVAGVFFAPMEYTETSDRANRRIAATLERAGIPVVLLDRCVERYPDRSNFDLVGIDNQRAGHLLTRHMIQAGAKRILFAARRFSASTVEQRIAGYREALLAADRGATFAVVTGDFEDVAFVQKMLQSERPDAIICANDATAARLMQTLLGLGVRVPEEIRMSGVDDVRYARFLPVPLTTIRQDCLEMGTVAMGIMMDRLNRPDHPVRDVLVKSELIVRSSSGMPQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6I8</accession>
    <name>E8X6I8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4304</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572982.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71072">
        <property type="protein sequence ID" value="ADW71072"/>
        <property type="gene ID" value="AciX9_4304"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4304"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_0"/>
    <dbReference type="OMA" id="GWNFLVQ"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="476" mass="49289" checksum="5B0F9A929FE548D5" modified="2011-04-05" version="1">MVSQVKSVHPDVILGICCMSLLLVGMDVTIVNVALPAIQHDLHASVSGLQWIMDSYTLVVASLLMLAGSVSDRVGRRLVFQIGLSLFTAASFLCSMAHNIEQLVAFRALQGLGASMLNPVALSIVANVFKDPKERARATGVWGAVGGVSFAVGPLLGGALTQAIGWRSIFWVNVPLGILAVVLAAVFVPESKAARGRRFDPVGQLLVFTGLTALTYAVIAGAHEGWSSRLIVGLFVVAAASLVGFLVYEAKQAEPLVDLRFFRSVPFSSATLLGLCAFASFAGFLFLNALYLQQVRGFSAFHTGLCTLPLAVTMMVFSPVSGRLVGVYGTRPSLLISGAGFMLGTLLLTGLSGGTPLWELLLAYGLFGTGLGMVNPAITNNAVAGMPLAQAGVAAAIASTSRQVGAALGVAIAGTVVSASRASATGASNFAQATHPIWWVMTGCGTVVMFLGWASNTEWSRASAARAASLLGAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6N4</accession>
    <name>E8X6N4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3908</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582202.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71184">
        <property type="protein sequence ID" value="ADW71184"/>
        <property type="gene ID" value="AciX9_3908"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3908"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_0"/>
    <dbReference type="OMA" id="ARPVYMS"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114869" checksum="2E90D01B02340CE1" modified="2011-04-05" version="1">MSGFAIRNPYLIIVVCLLIAILGTVSTASMPVDMFPPIDLPVVAVATFYSGMPPQQIETNITYHLERQFTLAGGIDHMESRSLPGVSLIKIYFHTGVNPDAAAATISTLAMADLHDMPPGTYPPIVLKQDASSMPVALVTLGGEGLSESQLKDTAQNFVRNQLASVQGASVPQPFGGKWRQIMLYADPYKLEANQLSPMDVVRAVNEANVVLPAGDAEIGRFDYNIYTNSILKGMDDIANVPLKMEGQNPVRIGDVAEPKDSFSRQYNVVHVDGKRAVYLPIFKQGGDSNTISIVNGVRATLKKLYDVPASLKTAVVFDQSRFVRTAIETLVHEGGIGLFLTCLMILVFLGSVRATLAVFFSIPLSILATFFVLHLAGNSLNSMMLGGLALALSRLIDNSVVVLENIFRHLEGGESPTVAARNGGSEVALPVLAGTLTTVVVFFPVTLLFGVSKFLFTALASAVVVSLLASYFVALTVVPLFCANFIKSPHGDVPVALGAGVGSQHPVTPAPSSHSKTGLGARFTAGFNRGFEGLLVRYESLMQRVLEWPRATLLWCGLGCLLSLLLFPLMGLSFFPRTDAGQFVINFKAPSGTNINATEQETSHLESIIRTIVPKHDLGMIVSNIGVDPGFSALFSSNSAAHTAFLQVALQPDHATSSFTYIDRVKAEMKKQMPELQAFFSSGSLVDGVLNMGSPAPIDVRVTGSDMTQDVDIAQGIANKVREIHGVADVYIPQDVDYPSLRLTIDRTRASELGLTEKEVVSNIITALTSNTMIAPSIWIDPKSGNNYFLTVMYKEGQVKSLDDLRAIPLHGEHITQPTRLDMVANIQQFNAPTELDHTQIRRAVDVYVRPQEEDLSRITKQIEKILSDSKLPHGVEAKLSGSVESMNASFRSFAIGLTLSVLLLYLILVAQFRSFLDPFIILLALPPGITGVIVALLLWGSTLNVMSLMGVVMLAGIALSNSILIVEFAHHLLSEGMQVREAIVTSCRVRLRPILMTSLATLIGLLPMALKLGEGSESYAPLAQALIGGLTLSVAFTVFLVPAGFYLAYKDRVVSSPVEFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8X711</accession>
    <name>E8X711_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3834</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582142.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71120">
        <property type="protein sequence ID" value="ADW71120"/>
        <property type="gene ID" value="AciX9_3834"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3834"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_0"/>
    <dbReference type="OMA" id="YKKRLMQ"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="216" mass="23342" checksum="17CA9FD4E74AC344" modified="2011-04-05" version="1">MAELRIMIADDHDLIRRGLRTLLGTRSGWTVVGEASNGVDAVTMAASLMPDIAILDFSMPGLTGPEAAARMRVCAPRTKVLVLTMHDSEEVLREVLQAGAKGFMLKSDADRDLLMAVQRISESDEIFVSERAVSLRGGPLNVSGAGKASLAQLTVREREVMRLLADGMTSKEAAARLCISTRTVESHRINISRKMSFGSVADLVRYAIRNGIAAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B4</accession>
    <name>E8X7B4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4397</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71348">
        <property type="protein sequence ID" value="ADW71348"/>
        <property type="gene ID" value="AciX9_4397"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4397"/>
    <dbReference type="HOGENOM" id="CLU_138473_0_0_0"/>
    <dbReference type="OMA" id="MIRILFD"/>
    <dbReference type="OrthoDB" id="1738589at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="156" mass="17610" checksum="A006668028158B76" modified="2011-04-05" version="1">MRKILLGPDSRKTNEAATDWIDLCEQTTAEISSEDHLHPLEDALRLGTEGGWRASTPGPQQIRLKFNSPQHIRRIRLEFTETQVSRSQEFALFVTTAREPRREILRQQWSFSPSGSTTELEDYKVDLPGVTVIDLELDPGRHDAGVFASLQALLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7C6</accession>
    <name>E8X7C6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71360">
        <property type="protein sequence ID" value="ADW71360"/>
        <property type="gene ID" value="AciX9_4410"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4410"/>
    <dbReference type="HOGENOM" id="CLU_1132342_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="245" mass="25876" checksum="2F493F2E36A2998A" modified="2011-04-05" version="1">MIAQASVTSLAATWRQGRRAASRGLICGYVDSYTLLTFGVYTSFMSGNTISTGMNGGQAKYVPASHALLPIPFFVLGAFCGFLIQKNKNTKENSRVSMCVAALLFSGVAAALGGASTSVCVMILSCGMGMMNTTLSHIGGQPVNLGFVTGDLKSIGEHIANLVNRSPVTKPEGRWDTHWLRLATLGSVWTSFLVGAVGGAAMATRVHAWTLLLPALFLVFLVLTEFPDEVSKVQPGATLDSPIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7D5</accession>
    <name>E8X7D5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4421</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573088.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71369">
        <property type="protein sequence ID" value="ADW71369"/>
        <property type="gene ID" value="AciX9_4421"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4421"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_0"/>
    <dbReference type="OMA" id="CSDQWPG"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="154" mass="16780" checksum="2D38638FEBBC4326" modified="2011-04-05" version="1">MPILPAGTIAPEFSLHVTPDQKLSLSELRGKPVVVAFYPADWSPVCGDELSVFNEILPELLKYNAELVAISVDGAWCHDAFAKHKHLHFPLLSDFEPKGETARAYGAYRENDGVCERALFVLDKNGKITWSYCSPVAVSPGADGILSALEALPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7H8</accession>
    <name>E8X7H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4466</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71412">
        <property type="protein sequence ID" value="ADW71412"/>
        <property type="gene ID" value="AciX9_4466"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4466"/>
    <dbReference type="HOGENOM" id="CLU_344121_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="822" mass="88997" checksum="A0D3BD42E8C92160" modified="2011-04-05" version="1">MRATHLARYLVLCALGLPGAGSRFQVLAQTARVEGSARGTRASPPDLFPAERRFSIQQPTKPLHLGEPNDLSVTLKGEEVTTIFVMQELIESNKRSPWLDGGDSEPQLQRKPDGQTYITIVPQRPGKLEVVVNVLFSDGGMDEQSTMVDVVAAQPPTAIFSSSAFGDVLTMALSEQGRRKFLQMKASYPGLKRPIPVVLDDAKFHITMDPVNPPIHFDPQTAEVKALQSGEALIETLYGGLLKTICVQVRENSVIYDHSKCGSLRAGGEQSAQAAQPSELKLPYGPMDSRTGSFLADERVELPALTYPLRIAENNPVVLKLNGPAIARIECHPDSGNVPCVPWTGDWSRQGLPFKRNADGTTTIDLFPMEFGKHTYTFFILFVDGGVALKEITSEVVGGAARPTSIGSSCTKQPLEDDLPIRLEPGQDAYFSKKIIVPRACYDGVRFPVQLPPTAVTYRVRNEGKKPVIDIDDSKGSVSGLRVGQALLQQSFGGFIRATCVVVAERDDPDASNCRRLRAKFGVPLPPLRARVKPPETADQIAVDEPGIPGGIGGIISLSSPSTISIQLPPLPVLSALAGARLSPSVRDRFNADTRLKINADGLVAELLEPTKLPVQISGPDVLTVSIGQQLIEYSGHPSSKPYLEPAASEERNADRIGREADGSTYLHLVALRTGTVEFHISVLFVDGGVATRTVRIPVKLPVSKRLLLLNVRNPQMRDGYSEASVLHLTTGPPRSQRNLYPALVVDRNRRAVALSPGEVQFILEQSDPIIQLDPKTGIVTALNPGRAVVRTRYASTETSTCIVVQSDVTHSLPASCAEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7S5</accession>
    <name>E8X7S5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4579</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573228.1">
        <property type="nucleotide sequence ID" value="NC_015059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4579"/>
    <dbReference type="EnsemblBacteria" id="ADW71509">
        <property type="protein sequence ID" value="ADW71509"/>
        <property type="gene ID" value="AciX9_4579"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4579"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041131_0_0_0"/>
    <dbReference type="OMA" id="WEPSSAF"/>
    <dbReference type="OrthoDB" id="14928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="462" mass="50703" checksum="3057640791F9E110" modified="2011-04-05" version="1">MSWKMGKIIHQTSNFFVVMLLVLITQHGSFDKVMGAQEPLHVHAITDAVKNRANATRASLEAARQSDSFVDAVGVDTHLSYDNTPYYREWPKVSALLRSSGIRHIRDGYHDWEPSSAFVKEHRELALAGIHTTYIIPNDPKTTSDDIVRFSHLVKDLEALEAPNECDAGQNCGGGGKRGIENAVNFQPLLHRTGDLLDVPVLGPSFTSQEAYAGVGKLSQMMTMNNLHVYFGGRNPGNQGWGAGDPEGHNYGSLDWWIDQARLDGDHLPVTITETGYLMPEKPTPYTLPRPLGGAYIMRTLLLAFNHHVTRTFLYELLDEVSSPDYGLLTADLQDKPAFTALRSLIKLLSDPGPPFAPDALPYELRGGDKNLGHTLLQKRDGTFFLIVWNEESQYDPAKCVLTVLQPKKITLQLGPGFVVTSISTFPDTGVMTTTATAVSGATTSLSIDGNPTIIKISSHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W7</accession>
    <name>E8X7W7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4621</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71551">
        <property type="protein sequence ID" value="ADW71551"/>
        <property type="gene ID" value="AciX9_4621"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4621"/>
    <dbReference type="HOGENOM" id="CLU_3043938_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="5955" checksum="ADBE0778FD6198E8" modified="2011-04-05" version="1">MALGKRWLGCMLIGVGLMLFGISRQHWQEWAGIAILSGGIVLVLPNRIIGRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV65</accession>
    <name>E8WV65_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0166</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578568.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0166"/>
    <dbReference type="EnsemblBacteria" id="ADW67240">
        <property type="protein sequence ID" value="ADW67240"/>
        <property type="gene ID" value="AciX9_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0166"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760105_0_0_0"/>
    <dbReference type="OMA" id="VSITDHD"/>
    <dbReference type="OrthoDB" id="872447at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="45026" checksum="3595EFDF34A39244" modified="2011-04-05" version="1">MQPQSGPQSKVSYIWEESMATLPYSAGVSLHSHTSVSEESLTFIHKMGTEMAVFAPLFKRYEKRAAELYGLKLDFLKGNWRPPLVPRMAYEVERKQIARLGLDAHVSITDHDTIEACLLLRTLPVARRIPMSVEWSAPYGTTCFHMGIHNLPSADAAGWMERFARFTEAPSDEVLHGMFAELHAIPQVLIVLNHPLWDLYAIGQKAHEAELERFLTVNGEFMHALELNGLRHAKENRDVMRLARRWSQVVISGGDRHGLEPNANINLTNATSFNEFVHEIRVERKSHVLFMEQYKKPWEQRITDSTIDAITDYPQFAQGWQRWDERAFHPDADGVMRPMSELWVGGRPPRALMVSIQIVRLLRHRTFSMWLSLAFPGVNRVGVEREIVPDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV84</accession>
    <name>E8WV84_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0185</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578587.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0185"/>
    <dbReference type="EnsemblBacteria" id="ADW67259">
        <property type="protein sequence ID" value="ADW67259"/>
        <property type="gene ID" value="AciX9_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0185"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043026_0_0_0"/>
    <dbReference type="OMA" id="LMIDTGH"/>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="6">
        <location>
            <begin position="44"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="316" mass="35950" checksum="121E188EC0EC41D9" modified="2011-04-05" version="1">MAETLTATAPDTTLRTTEQRLSHLRLLEAESIHILREVASEFEKPVMLYSIGKDSSVMLRLAQKAFFPAPIPFPLLHIDTGYKFREMIEFRDNMAASIGAELLVWRNEAALAAGTNPIALDTKRCCGLLKTQALLDGLTHYGFTAAFGGARRDEEKSRAKERIYSFRDGAGQWDPKNQRPELWNLYNARIHPGESIRVFPLSNWTEMDVWQYIHLENIPVVDLYFAKERPMYLRGDALLPTEQDFVARKGEQPVMVKSRLRSLGCSPCTGAIRSDADTIPKIIEEILGFRSSERANRVIDHDQEGSMELKKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD0</accession>
    <name>E8WVD0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579701.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1316"/>
    <dbReference type="EnsemblBacteria" id="ADW68378">
        <property type="protein sequence ID" value="ADW68378"/>
        <property type="gene ID" value="AciX9_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1316"/>
    <dbReference type="eggNOG" id="ENOG5030YRM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891186_0_0_0"/>
    <dbReference type="OMA" id="VGYMRNG"/>
    <dbReference type="OrthoDB" id="1529664at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003229950" evidence="1">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="320" mass="34317" checksum="7DE4D9730A94C7F2" modified="2011-04-05" version="1">MRMKLLSALTFATLLPLAVAQAQQEGLVPTQTLIRVDSKNPAIPTLDTTKLEVNNRQVQLTSIQPIPPTGVQIALLIDDGLRRSAAVQLEDVKKFIETLPTGTEILVGYMSNGGVRVASQFTTNHEDAVNAIRIPFGIPGISASPYFCLSEFVKHWPGNDSSSDSGPRSGTSARFAIMITNGVDPYNGSTSVLNQDSPYVETAIADAQRAGVAVSSIYYGDAGIRGGRASFSGQSYLNQLSQATGGEAYYQGMGNPVSLLPFFKEFQKDISETFIATFQADAGAMGRTQLVRINVKSSIPKLKLRHADVVRPGNHEAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF7</accession>
    <name>E8WVF7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">AciX9_1345</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579728.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1345"/>
    <dbReference type="EnsemblBacteria" id="ADW68405">
        <property type="protein sequence ID" value="ADW68405"/>
        <property type="gene ID" value="AciX9_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1345"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_0"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="336"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="471" mass="51294" checksum="096B4B9C988F3A1E" modified="2011-04-05" version="1">MAKDMQIAVVGSGYVGLVAAVCFAEMGHDVICVDNDERKVAALQGGDTLIHEDHLPELLNRYRNTKVRFMTDLAEATRESQAIFIAVGTPQSETGDADLSYVEAVACEIARSINSYKVIVEKSTVPVYTNEWIRKVMERNGVARDLFDVVSNPEFLREGSAVSDFLHPDRIVVGSDTARAAAVLAEVYAPLTTGAYYTNANLIPGVCSVAAPPVLLNTSTKSAEIIKHASNAFLALKISFINAVSNLCEATDANVEQVARGMGLDSRIGPKFLRPGIGYGGSCFPKDVAAFRSVAEQLGIDFSLLTEVEKINESQKKRFLSKVRSALWTLRGKRIGVLGLAFKGETDDIRESPAIDLVEMLLAEGCSVAAYDPAAIKRTEEIMPASTTLRYASSSYDAAQDADALLILTDWQEFATLDLTEMHKALRYPIVIDGRNLYDPSVMLQHGFTYLSVGRPAAHPIHNLRRQPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN8</accession>
    <name>E8WVN8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpD</name>
        <name evidence="13" type="ordered locus">AciX9_2537</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580882.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2537"/>
    <dbReference type="EnsemblBacteria" id="ADW69567">
        <property type="protein sequence ID" value="ADW69567"/>
        <property type="gene ID" value="AciX9_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2537"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_0"/>
    <dbReference type="OMA" id="MLFGQMN"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017691">
        <property type="entry name" value="Alt_ATPase_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03305">
        <property type="entry name" value="alt_F1F0_F1_bet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="147"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="53097" checksum="4AD4EA7834B3C95D" modified="2011-04-05" version="1">MSDEPVAPHCGVVVSIRGSVVDAQFSGQLPSVFSILRCGTKEAIVIEVMEQIDQDRVRGIALTATQGLARGMTVRDTGMPLQAPVGKKIISRMFDVFGHAIDRQPEPANTEWRSVHRAPPPLSDRLTKSEVFQTGIKAIDVLVPLERGGKAGLFGGAGVGKTVLLTEMIHNMIGHQKGMSIFCGIGERCREGEELYSGMKDAGVLKDMVMVYGQMNEPPGARFRVGHAALTMAEYFRDDEHRDVLFLVDNIFRFLQAGMEVSGLLGQMPSRLGYQSTMGTELSGLEERIANTHAGAITSIQAVYVPADDLTDPAAEHVFGHLSASLVLSRKRASEGLYPAIDLLQSNSAMATSAIVGERHYRVAQQIRKTLAEYEALKDIVAMLGLDQLSPADRLTVGRARRLERFLTQPFFATEQFSGLKGKQVSLEDALDGCERILRDEFKDVPESALYMIGAISEAKQAPPQKKQDGKATPTSMPPPAAPAGSAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVQ9</accession>
    <name>E8WVQ9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2561</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2561"/>
    <dbReference type="EnsemblBacteria" id="ADW69588">
        <property type="protein sequence ID" value="ADW69588"/>
        <property type="gene ID" value="AciX9_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2561"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="9789" checksum="08CF3E539909CDA1" modified="2011-04-05" version="1">MAQYLGKVMWFSNAKGFGFLSRDGGADVFVHFSAIVNDGYKSLAEGEDVSFDVVQGDKGPQAAEVRRVVMGSTQAPEDPRVPSAVHLQVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVV0</accession>
    <name>E8WVV0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3708</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582018.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3708"/>
    <dbReference type="EnsemblBacteria" id="ADW70709">
        <property type="protein sequence ID" value="ADW70709"/>
        <property type="gene ID" value="AciX9_3708"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3708"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_2_0"/>
    <dbReference type="OMA" id="ENEINTW"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW70709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="115" mass="13369" checksum="69A9EE51AA082F77" modified="2011-04-05" version="1">MPRELRAYLNDVIDSGRDILTYLGDMSLDDYRESSLVRAAVERKFSIIGEAINQALDHYPELQGKIKMDRDIVDFRNRVIHGYFSVNDVLVYSLTKRDLPELMDEMQNLIGEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX5</accession>
    <name>E8WVX5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="15" type="ordered locus">AciX9_3733</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582043.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3733"/>
    <dbReference type="EnsemblBacteria" id="ADW70734">
        <property type="protein sequence ID" value="ADW70734"/>
        <property type="gene ID" value="AciX9_3733"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3733"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_0"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="13">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="14">
        <location>
            <begin position="427"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADW70734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="672" mass="74208" checksum="33AB47E2142A402D" modified="2011-04-05" version="1">MAVTEQYDVVVVGAGHAGCEAAVASARMGLRTALFTLNLDLVAQMSCNPAVGGIAKGHLVREIDSLGGIMGLIADSAGIQFRLLNTSRGPAVWSPRAQCDKALYRVRMKELLENQPNLHLKQAEVVDVLIEGPGRREQGSAAAYPDPCSLIPVPCIRGLKLRDGREIHAAATIITTGTFLNGLIHCGEQQYSAGRSGEPASVLLGESLKRLGLRETRLKTGTPPRLDGRTIDWSQFPEQPGDPEPTPFSLRTRELPLRQISCHIAHTSPETMWLIRENAHRSPMYTGQIEAIGPRYCPSIEDKIVRFPDKPRHQFFLEPEGLTTHEVYINGMSTSLPQEIQLQMVHSIPGLENTVMLRPGYAIEYDAIDPTELDRSLRVKSYEGLYLAGQINGTSGYEEAAAQGLMAGINAALSVKRARGDASAEPFHLDRTEAYIGILIDDLISKGTDEPYRMFTSRAEFRLHLRIDNADRRLTPHGHRLGLIGDENWADYEARQHRAAAFKTLLETTRLNAREIPADLYAKLLAGSAQGVDSFAGVLLSDLLKRPDLVIEDFVPLLTEALAAPIFTAWQDETFPARTRNERRAVETEIKYAGYLSQQLRSIGKMKQAESTRIPPTFDYTTISGLSREMQQTFQRVRPLTLGQASRLPGVTPAAVSLVHVYLEIQSRRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW68</accession>
    <name>E8WW68_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1392</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1392"/>
    <dbReference type="EnsemblBacteria" id="ADW68451">
        <property type="protein sequence ID" value="ADW68451"/>
        <property type="gene ID" value="AciX9_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1392"/>
    <dbReference type="eggNOG" id="COG3667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034455_0_0_0"/>
    <dbReference type="OMA" id="QEDSTHI"/>
    <dbReference type="OrthoDB" id="442021at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234101" evidence="2">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="494" mass="54366" checksum="E4AEEE8A5DBC891C" modified="2011-04-05" version="1">MKLQHLLASASALLCLSVSQAQQSPMPNMPGMEMHPPAQAPKQQKPMQDMPGMDMTDSSMSMNSMMKPATTLIDSILQHSSSGTTIETPSEPMRMWMSATPRRGWSLMLHGDAFLADIQQHATGTPTPPPAAVCTEIAAACITPDHRGTDKLFSTNWVMPMGMHSLNLGSHQGQFTLRSMLSIEPATVQQGFYPELFQQGETANGKAIVDGQHPHDFVMELAALYDLHLSKHSLLSLYAAPVGDPAIGPTAYPHRLSASEDPIAALGHHQEDSTHIAFNVFTAGLTYKTLRIEGSGFHGAEPTEARWHFAPSPNGHAVDSYSTRITWVPTANLSAQYSIAHITSPEALHPGEDQGRQTASVMYNRPRKDSNWSNTFIWGRTKSLKDGSIENSYLAESLLNFRTNNFAWTRVEFADRTSELLLDQYPTNPNPPEITLGHVQAYSLGYDRQYRIAPHLLAAPGAQFTLYRAPDPLVSTYGRTPFSAVAFIRFRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WW88</accession>
    <name>E8WW88_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579793.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1413"/>
    <dbReference type="EnsemblBacteria" id="ADW68471">
        <property type="protein sequence ID" value="ADW68471"/>
        <property type="gene ID" value="AciX9_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1413"/>
    <dbReference type="eggNOG" id="ENOG5032Y6R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046358_0_0_0"/>
    <dbReference type="OrthoDB" id="1723076at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="120" mass="13322" checksum="22D36661D5950DFB" modified="2011-04-05" version="1">MTMNSSTSRPTTDHNQIRLWASSQNAMPAELLPGHVDSVPTQLHFFIPGNQSHEPRLRIIGWEDFFAAFEAHGLAFVYEILPGGKPGRRFELLQIEDKSPAAQQADALPHDSDTAQQSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWB6</accession>
    <name>E8WWB6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1446"/>
    <dbReference type="EnsemblBacteria" id="ADW68499">
        <property type="protein sequence ID" value="ADW68499"/>
        <property type="gene ID" value="AciX9_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1446"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_4_0"/>
    <dbReference type="OMA" id="RISEWHL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="309" mass="34871" checksum="0AEC48BE94837CBB" modified="2011-04-05" version="1">MKSRESTVKLRYPGGRFRREWISDAAGWQSLRLRISEWHLTSADVIEPPPSDDPSFSVLLNSAFHLDERFRGQWRGQLYTKGTGELSPARHQRRLRQNFVGQGSLNTLGVHIPQATVDRVAQELSTPGNAVGSSLQDLPFMDDRPLSGFSFTVLAALRDKAPDFYAQSAAQWLAAHLLLGPFKAFEWHQSLTHERVSDHRLIRVLEYIDAHLSEHLDLRILSQEAGLSPFHFAALFNKAVGATPHRHVHHLRMKTAQSMLRTTDKSTLEIALACGFGSASHFASAFRREFLQTPTEYRSSQQFSEITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWJ7</accession>
    <name>E8WWJ7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ordered locus">AciX9_2636</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580976.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2636"/>
    <dbReference type="EnsemblBacteria" id="ADW69661">
        <property type="protein sequence ID" value="ADW69661"/>
        <property type="gene ID" value="AciX9_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2636"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_0"/>
    <dbReference type="OMA" id="VLDCVPM"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="614"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="816" mass="90448" checksum="0C8AA894DD70430D" modified="2011-04-05" version="1">MPSDFVSVIKPTGVKTGEVVGQGEVGRGAIPVLPVRDTVLFPHAVLPLTVGRESSIQLIQSLGEEKTILVVAQQDARLDTPEGTDLHSVGTRATVHKVVKMPNQSLFVFTEGNERVRLGEFTQLMPFMTAEYEILSEVEPEKTPELEALQRNVVSQFQQIVTSSPTLSDDLQTIAINIDEPGRLADFIASSLPFLTTTDKQELLETSSVSARLERVNKHLAKELEVQQLRNKIQSEVQDSVQQSQRDYYLREQMKAIQKELGDLDDTQKDIAELKEKIENAGMPEETQKDALKELARLSRMNPAAADYSLTRNYVEWLAVLPWAKTSSGEVDILKAKAFLDEDHYGLKKVKDRILDYLSVRRLKPDMKGPILCFVGPPGVGKTSLGKSIARALDRKFSRISLGGMHDEAEIRGHRRTYIGALPGQIIQHLKRVEVKDPVFMLDEIDKLGRDFRGDPASALLETLDPEQNNTFRDNYLDQPFDLSKVLFICTANQLDTIPGPLLDRMEIIELTGYTEEEKVAIAQKYLIPRQIKENGVPDDMMEFPQESVALVARHYTREAGVRKLEQQIGTVCRKLARKIAEGRTEKLVITPEIIHEFLGGIKVRVDTEIAERTKRAGVVVGLAWTPAGGDILFIEANKMKGKGGFNITGQIGDVMKESMQAALTWVRSNAIGLGLDEDFTKDLDLHIHVPAGAIPKDGPSAGVTMATALVSLLTDKPVRPLLAMTGEITLSGDVLPVGGIKEKFLAAKRAGVRDVILPVDCKQQVDEDLTPDQTEGITIHYARRIEDVLAVALPKNLVEEVQDEEVREEVLQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWM0</accession>
    <name>E8WWM0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="4">G6PD</shortName>
            <ecNumber evidence="4">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zwf</name>
        <name evidence="8" type="ordered locus">AciX9_3765</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582073.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3765"/>
    <dbReference type="EnsemblBacteria" id="ADW70765">
        <property type="protein sequence ID" value="ADW70765"/>
        <property type="gene ID" value="AciX9_3765"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3765"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_0"/>
    <dbReference type="OMA" id="PDEGIQM"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="7">
        <location>
            <begin position="180"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="466" mass="51542" checksum="81F0705936FC0609" modified="2011-04-05" version="1">MSQVHSDALVFFGATGDLAYKKIFPALQSMIKRGTLNVPVIGVAKAGWNLDQLKDRAKDSLEKHGGLDQGAWEKLSSLLHYVDGDYEDPATFTAVRKELGDAKNPAHYLAIPPSLFEKVVEQLVKSGNAEGARMIVEKPFGHDLASAQELNRILLSAFPETSIFRIDHYLAKGPVYNMVSFRFSNSFLEPLWNRNYVESVQVTMAEDFGIQGRGSFYDQTGTIRDVIQNHVFQVMCNLAMEPAAAGDSESVRDEKVKVLKAIAPITPDNLVRGQFRGYLDEKGVAPDSKVETYAALRLQVKSWRWDGVPFFIRAGKNLPITCTEVMVRLRKPPATNSSSGDPAQNYIRFRISPETTVALAVSVSSPTGTGKRGEVELVASRHPEPSEMEAYERVLTDAMAGDATLFARQDYVEEAWRIVDPVLNTDTPVSVYEPHTWGPEGPENVIPPGGWDSPQPEQGDNFRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWQ5</accession>
    <name>E8WWQ5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0311</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578711.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0311"/>
    <dbReference type="EnsemblBacteria" id="ADW67383">
        <property type="protein sequence ID" value="ADW67383"/>
        <property type="gene ID" value="AciX9_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0311"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112762_0_3_0"/>
    <dbReference type="OMA" id="NLMKYCL"/>
    <dbReference type="OrthoDB" id="1153621at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="158" mass="16796" checksum="033B3AFA88203F24" modified="2011-04-05" version="1">MAVDFFLELDEINGESKDAKHTDQITIQSFSWGARQHTSVSGTGGSGAGRATLADLMVTKEYDASSGPIYKALLLGTHIKTGVLSAVKSGGDGSAFLTISLGELFITSIQIGASNETPTESVTFSYNHIETAYMQQMENGQIQAKAPVIYDLKANQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX76</accession>
    <name>E8WX76_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2694</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581033.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2694"/>
    <dbReference type="EnsemblBacteria" id="ADW69718">
        <property type="protein sequence ID" value="ADW69718"/>
        <property type="gene ID" value="AciX9_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2694"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533967_0_0_0"/>
    <dbReference type="OMA" id="GFANDMA"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="49777" checksum="C343051DCB2A0C86" modified="2011-04-05" version="1">MDPVAPANHELKRELRLWDLVPMQILLVVGITWAGIAARQGGTHVFFWVVAVLTLFIPTAAVVMFCVRLWPEEGGVYSWTRNAFGPFAGFMSGWNFALWALLTVSNIGIITATSLSYGLGPSAAWMTDSHALVVWLSAGLFGLILIINLFGFGIGKWVSHFGTAVMVLVTFLLILLLFFHPHATAAHPHVSPQKPFLFGLPLLTLLSLNLFSKISFNALTGLEQVAVFAGETKDPARAILRSAWIAAPLIVLIYVLMTGSILTYIPMDQVDLTGPVPQILSAAFSGGSSSGLDVGLLLGRGAILALAVALVAQYAVIVAETSRLPLVAGWDGILPAWFTRLHPRWGTPTRAIVVIVGASMVAALLATSGAGKQEAFQLIVTSGNLLYGVYYLMMFAIPLFVGARFWMKVAAVSGFLVSLLAMGFNLVPIVAVANAWVFAGKVVGAALFLNLVGMGVYWRGTRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX82</accession>
    <name>E8WX82_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581039.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2700"/>
    <dbReference type="EnsemblBacteria" id="ADW69724">
        <property type="protein sequence ID" value="ADW69724"/>
        <property type="gene ID" value="AciX9_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2700"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119721_0_0_0"/>
    <dbReference type="OMA" id="NDANEIM"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230405" evidence="2">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="258" mass="27809" checksum="5774F5E663258DB9" modified="2011-04-05" version="1">METHRRRTGSSKMRVLATAALFSLTFVTLQAQDGPKADPPKADTPNPHHDTRPTQTFYLAHAAQANDGNEILTGVRIMVDPLDKLYLDPSLNAIIARASADDLELIARLIKELDRPRKAWRLTYTVIELDNGKRVGVQHTSLVVLEGGRTTVKNGSKIPLATGSSKGGDTQFTYIDVGLNIDASLDALGNGARLRSKIEQSSAVETKTIAEVTEPVIRQSVTEGSAVLVPGKAVTIGSMDIPGSTRHLDIEVLMDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXD7</accession>
    <name>E8WXD7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0398</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578798.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0398"/>
    <dbReference type="EnsemblBacteria" id="ADW67470">
        <property type="protein sequence ID" value="ADW67470"/>
        <property type="gene ID" value="AciX9_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0398"/>
    <dbReference type="HOGENOM" id="CLU_163140_1_3_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="91" mass="10272" checksum="DE2C345A6CD17810" modified="2011-04-05" version="1">MATWGIAKAKAQLSELIYEAEKTGPQKVTRSGRDVAVVLSIDEWKRLATPDRSETRPQRSVWDVLSNSPLRGSNLKIPRRRPSTRVIDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXG9</accession>
    <name>E8WXG9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578830.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0430"/>
    <dbReference type="EnsemblBacteria" id="ADW67502">
        <property type="protein sequence ID" value="ADW67502"/>
        <property type="gene ID" value="AciX9_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0430"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010471_0_0_0"/>
    <dbReference type="OMA" id="RWTSSAK"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07430">
        <property type="entry name" value="GH15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015220">
        <property type="entry name" value="Glucodextranase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09137">
        <property type="entry name" value="Glucodextran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucodextran_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="303"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="383"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="826" mass="91372" checksum="D198C84868377825" modified="2011-04-05" version="1">MNEKASDYRWLDDDGAAFGSPGVEPRWTSSKKDAVSTAYSASSRVWFTVSHGTLNEVYYPTIDRPQMRDMELLFTDEETFFHEEKRDFEYDFHYVDPGAPAVRVVASDLDGRYTVTKEFIADPHHPVVLMNVKIAGDEAVVSRLKCYVLLAPHLDGGGAGNSARSLSVAGRRTLLAWKGEHNSLAVGADCGFTRSSCGYVGTSDGYQDLSTHMKMQWQFGQALNGNVAVTGEIDVARNREFTIAIAFGDGHHAALSGMMQTLSTPYAEHAKRFIDQWHRAESPAALAKASTDGGRLMRVSHNVILTHEDKTYSGAFIASASIPWGASKGDDDLGGYHLVWTRDMVQSATALLACGRTETARRALVYLACTQRPDGGFAQNFWIDGSAYWTGIQLDEVAFPIILAWRLWKVDGLGVFDVFPFVEKAAAFLVRYAPVTQQERWEENAGYSPSTLAAVISGLVCAADIARAYQASELAGFLETYADWIESHLDEWTTTEDGMLLDGVKRHYMRIRPPAEGEPFHNPGVKPGFIRLANRGPEEESEFDAREVVDGGFLELVRYGIRRADDPLMVESLKVVDACLKYETPYGPCWRRYNHDGYGQKKDGGPYDGFGQGRAWPLLGGERAHYELAAGHDVKPFITAYEKFSSIGGMLPEQVWDHDDMPEEGLYLGRSAGSAQPLVWAHAEYVKLLRSVSDGKVFDTISVVAERYAVEPGTRTFQNTVEIFQTARPFATIPTGFTLRVVDRARFRMSYTLDGWATTTTVDSRVVGYPGSFADVVMPGEPGELEFTLFWPTTADAPEHWLGHNYKVAVTSQGPETMPAGAKPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK3</accession>
    <name>E8WXK3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579938.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1566"/>
    <dbReference type="EnsemblBacteria" id="ADW68619">
        <property type="protein sequence ID" value="ADW68619"/>
        <property type="gene ID" value="AciX9_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1566"/>
    <dbReference type="eggNOG" id="ENOG5033H52">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2493542_0_0_0"/>
    <dbReference type="OMA" id="HAPETRH"/>
    <dbReference type="OrthoDB" id="2025753at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9845" checksum="F2A461B92B0CC067" modified="2011-04-05" version="1">MSFTESYTCDICGDKKGTSGQWFLAWQDCLPLVRTEGTQPLIKLTRWEQEHAHEESVIHLCGNRCAGTLMERWMTEQHEQPTASCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN1</accession>
    <name>E8WXN1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579966.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1594"/>
    <dbReference type="EnsemblBacteria" id="ADW68647">
        <property type="protein sequence ID" value="ADW68647"/>
        <property type="gene ID" value="AciX9_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1594"/>
    <dbReference type="eggNOG" id="ENOG503014W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754859_0_0_0"/>
    <dbReference type="OMA" id="GYIFDRR"/>
    <dbReference type="OrthoDB" id="1553907at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="148" mass="16586" checksum="CD49D9DFC6CD6380" modified="2011-04-05" version="1">MATDQQEAAKIEQLAHLSPDDLDHAAGREREQLEGWVPELASDTEVREALEKAFDYRGNVTVTKKDGSVVEGYLFDRRTGNSLSDSFARIIPVSDKTKVNVAYVDIAALKFSDRDPAAGKTFEAWVKKYWEKKAAGEKNIQIEPEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXN3</accession>
    <name>E8WXN3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine or other phosphorylase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1596</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1596"/>
    <dbReference type="EnsemblBacteria" id="ADW68649">
        <property type="protein sequence ID" value="ADW68649"/>
        <property type="gene ID" value="AciX9_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1596"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_4_1_0"/>
    <dbReference type="OMA" id="ERFETEC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="204" mass="21074" checksum="D5881A96EACA312E" modified="2011-04-05" version="1">MRGVQPDPAQKRAGVYVYRLPGAVVVCAGMGAVRAGMAVQAALGAGEISVLVSAGLAGGCDPGLAVGRVMEARTVVDSASGERFETECGGDCGVLVTSHAIAGVREKERLFATYGAGLVDMEAATVARMAVMHGLPFRAIKAVSDAHDFELSSLSRFATVHGHFRTGAFALHTAVRPASWRHAMKLGSGSQLALLGLTEALKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXP9</accession>
    <name>E8WXP9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1612</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1612"/>
    <dbReference type="EnsemblBacteria" id="ADW68665">
        <property type="protein sequence ID" value="ADW68665"/>
        <property type="gene ID" value="AciX9_1612"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1612"/>
    <dbReference type="eggNOG" id="ENOG50345VJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2219408_0_0_0"/>
    <dbReference type="OMA" id="AYHETPG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233966" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="106" mass="11790" checksum="5D2171C58781F9FB" modified="2011-04-05" version="1">MKRLLLLPAFASLLLVAGCHDHAYYAPPPAYAPSNALFDLAGRNGFQMGAQDGARDSGSGYRFEPRRTRAYHETPGYDPGLGPFGPYQNAFRNSYLHGYDTGYYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXR2</accession>
    <name>E8WXR2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2733</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581072.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2733"/>
    <dbReference type="EnsemblBacteria" id="ADW69757">
        <property type="protein sequence ID" value="ADW69757"/>
        <property type="gene ID" value="AciX9_2733"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2733"/>
    <dbReference type="eggNOG" id="ENOG5032SVQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163980_0_0_0"/>
    <dbReference type="OMA" id="PMTTITI"/>
    <dbReference type="OrthoDB" id="1989319at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="100" mass="11287" checksum="68D6760EB8EF6346" modified="2011-04-05" version="1">MKMTERIKRNMQADKPMTLISLRLPDHVIEDLKEVAPTLGFGGYQALIRAYISNGLRKHLAEREALRVKESAVEEFSQRLLAHGVPEQAIKDAAAEMTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT4</accession>
    <name>E8WXT4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581094.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2755"/>
    <dbReference type="EnsemblBacteria" id="ADW69779">
        <property type="protein sequence ID" value="ADW69779"/>
        <property type="gene ID" value="AciX9_2755"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2755"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_3_1_0"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="393" mass="42768" checksum="4A8840A325ECE74E" modified="2011-04-05" version="1">MTDPAVNDQIVFFDTTLRDGEQSPGCTMHHDEKLRMAHQLAALGVDVLEAGFAIASDGDLESIRAIAKEVKGPRITSLARCKAADIEAAARAIEPAHHNRIHVFLASSDLHLEAKLRITRDQALEQAAESITHALRYTDNVEFSAEDATRSNPAFLLKLVIHAVSAGATTINLPDTVGYTTPDEYKALFARMKAEVPNSENIIFSTHCHNDLGMAVANSLAGVEGGARQIECTINGIGERAGNAALEEIAAALATRHDKFPYRHNLKMKQLYPTSKLLAEFISFGCSPNKAVVGANAFAHESGIHQHGVLANPLTYEIMTPESVGVPANNMVLGKHSGRRLLEQRLAELGHPLTRPELDEVYARFTTLADRKKSIYDQDLIGLLKPEDSIMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY40</accession>
    <name>E8WY40_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0507</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578907.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0507"/>
    <dbReference type="EnsemblBacteria" id="ADW67579">
        <property type="protein sequence ID" value="ADW67579"/>
        <property type="gene ID" value="AciX9_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0507"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_6_0_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230446" description="PBP_domain domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="33"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="39185" checksum="650FB016D76CD941" modified="2011-04-05" version="1">MKTALASLFLAATSAAAQLPQHHDVSSLTPYTSHQKVSGVIRVYGNNYIPTLMKQWEEGFQNFQPNVTFTTNLPGTEAAMAGITTGIADISFIGREGYRSEINGFKGRWGYLPLGIEISSGSFGTPHKTFSLEVFVNKDNPLPGLTMEQAQEVFGNNPTIKTWGDLGVTGPMATHTIHVYGYQFDTGMAGYFNRVVLHDKGTWNPSLKDFDNGHDAKGEVINAGNYILKALADDPDGIAFANLQYTNDKIRALGLADDHDRHHHGHADRAHHDRGDEHEHFVEATPETIWDRTYPIHRFTTLYINRKPGTAVDPKVREFVAYILSREGMQAVADDGAYTPINESVAVAQRKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA0</accession>
    <name>E8WYA0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1677</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1677"/>
    <dbReference type="EnsemblBacteria" id="ADW68727">
        <property type="protein sequence ID" value="ADW68727"/>
        <property type="gene ID" value="AciX9_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1677"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_5_0_0"/>
    <dbReference type="OMA" id="FFRGRWD"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="220" mass="24240" checksum="C0C718697B0C05C9" modified="2011-04-05" version="1">MSLQDQLDVITARTRQLVQADRLAVSEQAAAELFATGIEDSILEVGAVAPSFALTDASTGKLVKSEDLLALGPVVLKFFRGRWDPYCVTELETWRELYPEVRDRGAILVAVSPQTKRQNDFAVQQHGLSFPVLADPGCEVAERFGIAYTVPVPARNYYRSILVNIPFANAGLNYDTASEESWRLPLPALYLIGQDGLVRFAEAHADPRVRPEPADLLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYA7</accession>
    <name>E8WYA7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1685</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1685"/>
    <dbReference type="EnsemblBacteria" id="ADW68734">
        <property type="protein sequence ID" value="ADW68734"/>
        <property type="gene ID" value="AciX9_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1685"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022604_0_0_0"/>
    <dbReference type="OMA" id="QVESIYW"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230067" evidence="3">
        <location>
            <begin position="27"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="726" mass="77981" checksum="E3BCAC8DDBDF00A5" modified="2011-04-05" version="1">MNWNDIKAATSITLLLLSSTSQFALAQQQTQQAPPTQNQPNGGSQTNPTAPATPQPIQNDTTRDPNLPQAPDPKLTEPLFLRDTDKDYTHLKNHGIHGFRSLFAPYTATEVPLPRLGNSAGFSDLLRDGKIYLSLNDAVTLALENNYDIAIARINLDIADTDILRTKAGATFRGVSTGLVTNTLGGTTSTITGGGGPGGTSSASGGAGTGASGLVLSTNGGGPLPYNYDPVITGNLQYENLTTQESSTLFTGTNQLKTTTETYNFGYLQGFSTGSQLAVTYDNTRQTTSSPRSSFSPLLQPTIKLQFTQHLLQGFGPSINKRFIVEATNNRRITDSAFRQQVIYTVTQVESIYWSLVSAYEDEQAKERALNQSTALASDNRKQLQIGTLAPLDVVNSDSAVATDKQALITSQSNLEYQQLLIKQAIARNLNDPQLASAPVVPTDRVGLDRLPEEDMKVEDVVKEAFINNPQIEQAALELKNNQITIRGEKNGLLPIIDAYGSYGSTTIGGQQNSLLKCSDPITFAAEPCNSTNGGVNNTGYFNTLGNGFNGTAPDYIAGLNIQIPLRNRVAQADQARSQMELRQTEMRIQQLYTQIRIQVINAQYAITNDRANVVAAQTARDFNAQSLDAEQKKYKLGASTTALVLAQERTLAIGENNLIAATAAYAKDRSALAQILSNTLDRYNISLTDAATGTVTQKPNIPGLTPPVAPAPPKPLSATPPPLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYB6</accession>
    <name>E8WYB6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2799</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581137.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2799"/>
    <dbReference type="EnsemblBacteria" id="ADW69822">
        <property type="protein sequence ID" value="ADW69822"/>
        <property type="gene ID" value="AciX9_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2799"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_3_0"/>
    <dbReference type="OMA" id="ISRTEMF"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="222" mass="24931" checksum="501059C7B0427AA6" modified="2011-04-05" version="1">MQQFSRVDHSFNTEQFLSKTNTGRSLTTLRRGENLYVQGDQADCLYYVQDGDLTLSAVTAVGKQATIALLGRGDFVGEECLSSVRQTRMTTASALTDATLLRISRTEMFRLLQDESEMARIFVAYLLARADRIQADLIDQLSNSSEKRLARTLLLLSNYGNTDGSERLVPLISQDVLAAMVGCTRSRVNGFMNSFRRLGYIEYESNIRIRVKRGLLDVLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYC2</accession>
    <name>E8WYC2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2805</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69828">
        <property type="protein sequence ID" value="ADW69828"/>
        <property type="gene ID" value="AciX9_2805"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2805"/>
    <dbReference type="eggNOG" id="ENOG502ZE70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324840_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="207" mass="22461" checksum="8EAE3724749C0B48" modified="2011-04-05" version="1">MKLQVRTIAEERLCRFAALLLLGGGIASAQISARPLTGQEALTAHARIKPSLVAGITGPLLFQDKQGFEVSGAGFISFTMLPVRFYSRTDWGGTVYRCGVVFLPAQQSPVFLRTVGYDWTEVEQCEGIKGVGFVDGGGKMPPRIVLLWDAASPNASVNEPMVLDWNAGANRYVGNATISQRLENDLKTFTIAAIKQQLKLYAVEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG1</accession>
    <name>E8WYG1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2844</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581182.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2844"/>
    <dbReference type="EnsemblBacteria" id="ADW69867">
        <property type="protein sequence ID" value="ADW69867"/>
        <property type="gene ID" value="AciX9_2844"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2844"/>
    <dbReference type="HOGENOM" id="CLU_1592250_0_0_0"/>
    <dbReference type="OMA" id="MTHLTEP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="167" mass="17428" checksum="B57602AE1A3DBAF5" modified="2011-04-05" version="1">MTHLTEPELYTLLDPEAGAPANSHLAACSHCRAELDSLRATFTLLRETTTHYAASNAPRAMPSAVATRHQPLFNLRPALAGWASAAVLLAAGAVGLANLHHPAAPVAVNTPVAMAVAEPNTSDEALLQSVSDAIDQPVPTSLSILAEPSTQSQPTSSVQKVQPERTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYG7</accession>
    <name>E8WYG7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_2850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581188.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2850"/>
    <dbReference type="EnsemblBacteria" id="ADW69873">
        <property type="protein sequence ID" value="ADW69873"/>
        <property type="gene ID" value="AciX9_2850"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2850"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW69873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="25726" checksum="27E9BC6BFE12DDDD" modified="2011-04-05" version="1">MSDLSPRIALVTGASQGIGRACALALAAQGAHVALAARTLSKLEEVAAEITALGGTAHAFALDVSDETSIKSCAKAVQEHFGRVEILVNNAGITRDMLTLRMKRSDWDEVLGTNLTGAFLLTQACMQSMLKQRWGRVINITSVVGEVGAAGQANYAASKAGLIGLTKSLARELASRTITVNAVAPGYIETAMTAVLTDAQRAAMTQHIPLARAGTDADIAHAVAFLASEGASYITGHTLDVNGGMYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYI5</accession>
    <name>E8WYI5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_0511</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578911.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0511"/>
    <dbReference type="EnsemblBacteria" id="ADW67583">
        <property type="protein sequence ID" value="ADW67583"/>
        <property type="gene ID" value="AciX9_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0511"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_0"/>
    <dbReference type="OMA" id="YFCTTII"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW67583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="46538" checksum="A1BA4EF37456307E" modified="2011-04-05" version="1">MSVSLSSTAAHKPFYKTLYLRVLVGIIAGVIAGALFPNFGIAMKPFGDGFIKLIRMMIAPIIFLSVVVGIAGIGDIRKLGRVGVKALLYFEVVTTLALAIGLGVATLFQPGRGMNIDAKTLDTKSIAQYTSANAAPHGVDFVLNIIPDTFTSAFTKGEILQVLLLAILAGLALVALDKDKTLTNLADRLAHVSFKIIAYIMEFAPIGAFGAMAFTIGKYGLHTLVSLGKLLACVYLTSILFVVIVLGLICVSASINIFKLIRYLREELLIVLGTSSSETALPRMIVKMERLGCSKSVVGLVIPSGYSFNLDGTSIYLTIAALFIAQATNTHLTFGQQIFILFVLMLNSKGAAAVTGGGFITLAATLSALGTIPVAGITLLLGIDRFMSQMRSLVNLIGNGVATIIVAKWEGEFNTDQCNRALAGEVWHDNEAEEVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU7</accession>
    <name>E8WYU7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1735</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580102.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1735"/>
    <dbReference type="EnsemblBacteria" id="ADW68783">
        <property type="protein sequence ID" value="ADW68783"/>
        <property type="gene ID" value="AciX9_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1735"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_9_2_0"/>
    <dbReference type="OMA" id="VIMYLTP"/>
    <dbReference type="OrthoDB" id="430372at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="29"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="465" mass="50064" checksum="9F856CDB4ABDF588" modified="2011-04-05" version="1">MPDSNLPDRFEQIADREHGLQRSLSAAQLSMIAIGGAIGTGLFLGSSFAIGFAGPAVLVSYLIGALITLLLMGCLAEMTVAHPTSGSFGAWAEHYLSPLAGFLVRYAYWAAVVFALGTEVSAVAIYMRFWFPTIPGWVWIIGFTLALVLVNALNVRFFGTVEYTFSALKIIAILAFLVLGGWVLFSAPHGSGMGLVNYTAFGGFFPHGPWGTWVAVLVSLFSFFSIEMIAVAAGEAKDPKRAITQAFRATFLRLVLFYLLTLAVILAIVPWTQTQSISGIAQSPFVTVMTRTHIPGAAGVVNFVILIAALSAMNSQLYITSRMLFSLSRAGFAPAFFGTLSPAGVPVPALLLSTAGIAVAAILNAIYKDAAFAILLAISIFGAMFVWLMVFVIHLRFRAHHSANTLAFRMWGFPYTTLLGATLMSAALISTLFAPAFHLTLLYGIPFLLILTAAYYLRRRSIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYW4</accession>
    <name>E8WYW4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1752</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580119.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1752"/>
    <dbReference type="EnsemblBacteria" id="ADW68800">
        <property type="protein sequence ID" value="ADW68800"/>
        <property type="gene ID" value="AciX9_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1752"/>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_4_0_0"/>
    <dbReference type="OMA" id="HDIGMAS"/>
    <dbReference type="OrthoDB" id="1374098at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="335" mass="35844" checksum="97454F5A3CCC8C51" modified="2011-04-05" version="1">MLRVSYADLEQALTSTLIPLGFTPARAGLCARLFTETTCDGVYTHGLNRFPRFLATIRNGVVNPTAEPTLTSAFGAIERWHGNRGAGNLNAHASMARAIALARTHGIGCVALAQTNHWMRGGTYGWQAADQGLFAISFTNTLPNLPVWGSSAPTLGNNPLVLAIPRPEGRNIVLDMAMSQYSYGTLTAYAKRGAQLPYPGGFDAQGNMTTDPAAIEQTARALPIGLWKGSGLSLTLDLIAAMLSGGLATHQIETDSLKETGLSQLFLAIDPTHITDPEALAQTATQAIADLQSATPIDPSRPPRYPGEETLRLREENLRLGIPVEEEIWNSLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYZ4</accession>
    <name>E8WYZ4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2886</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2886"/>
    <dbReference type="EnsemblBacteria" id="ADW69909">
        <property type="protein sequence ID" value="ADW69909"/>
        <property type="gene ID" value="AciX9_2886"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2886"/>
    <dbReference type="eggNOG" id="ENOG5033JFP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049564_2_2_0"/>
    <dbReference type="OMA" id="MWERVQQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="270" mass="29134" checksum="1673F6916CDC1149" modified="2011-04-05" version="1">MQTALQPDQYQSYPTTQPVYVQNPSIFDHMSDALRSSVDRVLSLLISILPGLLAFILAFVLLTALGVFLSWAFRRILTALKFDERAARRQASGIADWSPSHSPTALVGRIVFWGCVLLGLIIGIQAFDASYATGSAAVSISLLPYVTHSVGAILILFAGNLIARYLARTVLIGAVNNQLQYARFLSMGVKWLVLVLTAAMVLDHLQIGSGIVELAFGILFGGIVLTLALAVGLGSRDLVTRSLERNQDRVDKVPSPTADPAAASESLRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ04</accession>
    <name>E8WZ04_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_2896</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581234.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2896"/>
    <dbReference type="EnsemblBacteria" id="ADW69919">
        <property type="protein sequence ID" value="ADW69919"/>
        <property type="gene ID" value="AciX9_2896"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2896"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="326" mass="35558" checksum="BC34511B5BCE92CE" modified="2011-04-05" version="1">MNDILNVRIKAGYGTEPILEDVQFDLQQGERLGLVGTSGAGKSTLVLALMGLLPWRRGWIKGEVVLEGVNLLALNERQARQVRGKRIALVPQSPLSALNSALSLQAHFEEAWRAHEEGGGNRFRARIKELLQKVRLPAEGHFLSRKPGEISVGQAQRVVLALALLHRPSVLIADEPTSALDPSTQVEILELLRQSNREDGTTVLYISHDLLSVLQLCDRMAVLQEGRIVECLPVDRIEELARHPATLALLRTLPVPPSVLRKYAERRVASPSTSQGLLQFQAPQGAATQASVSPDKPSGGTNPSGQPSEIIPFSPQSVRRSTTSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ13</accession>
    <name>E8WZ13_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ordered locus">AciX9_2905</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581243.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2905"/>
    <dbReference type="EnsemblBacteria" id="ADW69928">
        <property type="protein sequence ID" value="ADW69928"/>
        <property type="gene ID" value="AciX9_2905"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2905"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_6_2_0"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="15794" checksum="08043E2BBB996C98" modified="2011-04-05" version="1">MPEHRARTYHRNRVAQSFSEEIGAMLEGELSDPRIFPSVVTEVVLAPGGKSARVFVAVTGGEEEEASTLAALTTARAFIRSQIRERMGVRHVPELSFAIDRSEKMTGRMEELLDRNRKREKKRAATAQPEQPPTPPTTPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ19</accession>
    <name>E8WZ19_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581249.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW69934">
        <property type="protein sequence ID" value="ADW69934"/>
        <property type="gene ID" value="AciX9_2911"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2911"/>
    <dbReference type="HOGENOM" id="CLU_1308668_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="22894" checksum="AE7155F078F83C1C" modified="2011-04-05" version="1">MGYLGLDETTIKDDNLFQRLFWPSDHGGEADQLGKQGFWICLGVAVVSLLVMLMQGHWFLALLTFAFYALGGIGVREHDQPSAILVAVAYILNGVASAFSGIPPGILQLFATLLLLANIRGTWIAAKWAAHPDPDLMPQRFNTTFSDKLVDQMPARVWPKAKIPFFCIAVIYILLTVAGTVFIAVLGPARLKAAQNPTPTSQTIEVSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ74</accession>
    <name>E8WZ74_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579004.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0605"/>
    <dbReference type="EnsemblBacteria" id="ADW67676">
        <property type="protein sequence ID" value="ADW67676"/>
        <property type="gene ID" value="AciX9_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0605"/>
    <dbReference type="eggNOG" id="ENOG502ZVK9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989490_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="125" mass="13407" checksum="F9113D19EA5A39F8" modified="2011-04-05" version="1">MTINTLLPNPPAPDDPLKKSDPKKYYQDLFSSLEQAYFAATTTEAKLKIQIARDDAYTILTTITQAQITQDTTGLDAIQDTVTKNNAALEALQTEIGGLVNDIQVAADVEIAIANVLSLAGELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZH5</accession>
    <name>E8WZH5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1815"/>
    <dbReference type="EnsemblBacteria" id="ADW68863">
        <property type="protein sequence ID" value="ADW68863"/>
        <property type="gene ID" value="AciX9_1815"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1815"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089937_1_0_0"/>
    <dbReference type="OMA" id="WETPEYV"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233525" evidence="2">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="293" mass="32034" checksum="83AAA64405410138" modified="2011-04-05" version="1">MMIRTGLVLGMIGAAAVSWAQAGPRMTADEVMAKVRVGLGVTAPAGTVDTFKAGDPATPVTGIATTFTPTMAVLRKAVADGANLIITHEPSFYNHQDSSALFVKDPVYLEKIAYIKEHHLVLFRLHDTWHLRVPDGIAEGWVKKAGWEKYKKPGEQMFFTLPPTTLAGLAQDLQAKFGARIFRVVGDPAMRVTNVAYRPGASGEEKQVRALERDDVEVLVAGEASEWETVEYVRDAMLQGRHKGLILLGHETSEEIGMERFAEWLRGVVPGVTVTFIPAGEPYWLPGMPVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN5</accession>
    <name>E8WZN5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2986</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581323.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2986"/>
    <dbReference type="EnsemblBacteria" id="ADW70009">
        <property type="protein sequence ID" value="ADW70009"/>
        <property type="gene ID" value="AciX9_2986"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2986"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077411_1_0_0"/>
    <dbReference type="OMA" id="PIHCDIH"/>
    <dbReference type="OrthoDB" id="1869568at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233532" evidence="2">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="263" mass="27449" checksum="1BC796FA0523D5BE" modified="2011-04-05" version="1">MNKLSLPAALLLTLTIAGCKPDAATQKAEVQDKQATPAAAARPTAAPIDPATTGTVSGTISFAGKAPAPVTIDTSMDPACGIGTTTPVLSEQLLVNKGHLANVFVYVKTGPAAAMNAAPTSTAPVVLDQKGCQYTPHVIGVMQGGTVSFHNSDVTMHNVHVMGNETMDMSQGPKGAPQDKQFTKPELMIPVRCNNHPWMNAFINVSQTPFFAVTDATGQFNLKGLPAGDYTLGVIHEKLGEQTIQLTVKPQSTTKAAATFQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZR2</accession>
    <name>E8WZR2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3015</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581350.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3015"/>
    <dbReference type="EnsemblBacteria" id="ADW70036">
        <property type="protein sequence ID" value="ADW70036"/>
        <property type="gene ID" value="AciX9_3015"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3015"/>
    <dbReference type="eggNOG" id="COG5373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014077_1_0_0"/>
    <dbReference type="OMA" id="FLCNIAW"/>
    <dbReference type="OrthoDB" id="458141at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019286">
        <property type="entry name" value="DUF2339_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38434">
        <property type="entry name" value="PTHR38434"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10101">
        <property type="entry name" value="DUF2339"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="611" mass="66149" checksum="D5350B9FBCA1D45E" modified="2011-04-05" version="1">MHPDPANPSEPTPDTLASLAARIAALERQLAALQSPQPIPTAFAAQTAPIQPSPEPPPIPIPPPRPKQSFEDRLGSQIFNRIGVIALLIGTSLILKLAIEHGLIGPVARILIGLAAGVALVLWSERFRRNHFAAFSYSLKAVGTGVLYLTLWAAFHLYHLLPAPIALAAMILVTAWNAWMAFTQDAELLAAYALIGAFATPALLSTGGDHELFLFSYLLAIALAVAALLRLKPWPRLILGSFPATVLYFIAWYSDHFYQPNNASPIALTSAFLIAFFAAYTIPTLTLKSTEEQPQAYKLIPLALILANTAFLALGLYSVLQDTGHHDLLPWLMLALASISLGPRRLQQSPAAAGIRLSLAVTFLTIAIPLKASGRWITIGWLVEGVALLWTAARLSPRAEPEPPSPLAPHRIIRLLACAALTLGFFGAVSLPFWLDLEPTIHQAILNSRFATSLAAIAAFALAAWIARTASTRSSSTPDRLWPTITIATILALNLVSLQAGIDEIATFWNSTGHTHDSAFQTALSISAFLMAYGAALLAAGFWRRTAFIRWQGLILLVIAISKTFLYDVRDLSEGYRVASFMGLGALLMAVSFAYQKDWLNLRQPDPPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV4</accession>
    <name>E8WZV4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579093.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0695"/>
    <dbReference type="EnsemblBacteria" id="ADW67765">
        <property type="protein sequence ID" value="ADW67765"/>
        <property type="gene ID" value="AciX9_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0695"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_14_4_0"/>
    <dbReference type="OMA" id="LWESAQQ"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234021" evidence="2">
        <location>
            <begin position="22"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="47394" checksum="7F2D16A7784604CF" modified="2011-04-05" version="1">MKSLVLTLALATLAQAAQAHAQAPQSPAAAYAASAAPAADPRKPPASKPGALTLQQVVEQARARNPTLLAAEANLRAVRAQEIQAGVRVNPTLGVNGTTVTLPNDGSEGNPPSYAVQVTRLFERGNKREYRLEDARATTVQTAAQLEDTARQTILQVKQAFTKMLIAKEALELSNANLADYRHEVEIANDRYKAGDIGKLDFERLDLQLGSFESDQANAEITLLQSSYQLQTLLGSQTSSPDFDVTGDIIPPILTQTQAELTQAALTRRPDYAAARAGIVAAEANARLAIANGTTDPTLEGEYDRSGSYNSFGFNVNIPLRFFDRNQGNKETARLQAESTRFTSIAARNQVTSDVDQAWVGYTRAKALSDRFGQHYLDESIDVLGIARFAYDHGGLALIDYLDALRDARSSTSDALNAYSQTWMAIHQLSAASATELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0J4</accession>
    <name>E8X0J4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">AciX9_0789</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579184.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0789"/>
    <dbReference type="EnsemblBacteria" id="ADW67858">
        <property type="protein sequence ID" value="ADW67858"/>
        <property type="gene ID" value="AciX9_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0789"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_0_1_0"/>
    <dbReference type="OMA" id="WACADPG"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="187"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW67858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1149" mass="123449" checksum="B25B5BAE51F4B60B" modified="2011-04-05" version="1">MNETLTASPAASKKNQSAAAKPAPGLTFDRYFTTEGVSPYDQITWELRDAIIQDWKGKLIFEQKNVESPVDWSMTATNIVASKYLHGLIGTPERESGVRALITRVAESIRDWGMSAGYFADQKAADIFYAELAHLLLNQKVAFNSPVWFNVGCDRLEPNSDAQNWHWDADKRQVSFSTTGYTKPQCSACFINSVQDSLDSILTLAKTEGMLFKWGSGAGSNLSSIRGSMETLSGGGTASGPLSFMRGFDAFAGVIKSGGKTRRAAKMVVLNVDHPDIVDFIECKSKEEAKAYSLIAAGYDGSGPDSEAYSSIFFQNANNSVRVTDEFMSAVERDAEFSTRTVKERTPVTTGPARDIMNKIAENTWACGDPGMQYDTTINKWHTSKNTARINASNPCSEYMFLDDSACNLASFNLIKFVDSRGQFDIPAYRSAIAIVTTAMEIIVDSAGYPTEMIAKNSHDYRPLGLGYANLGALLMSFGLPYDSDAGRDFAGTLTAILCGDAYYQSALIAETCPPLLAATPFCQQATPEQGGACPGFYMNREPFLDVIRMHRAEVNKIGKSKHSNEPFSVPQLDSLIQASKDAWDAALIHGEHYGFRNSQVTVLAPTGTIGFMMDCDTTGIEPDLALVKYKKLVGGGMIKIVNNTVPSALTKLGYSDADMHAIVSYIDATGTIEGAPAIKAEHLAVFDCSFKPAKGTRSIHYMGHIKMMAAAQPFLSGAISKTVNLPTDCSVEDIAEAYLESWRQGIKAVAIYRDGSKGAQPLNVSTDKQKADDKETARKASVAGAEAAQVEIDETIAAEREAVSALASAAHISAQDNLAILSAAKDQLVANQQQVAALQAKLAAHLAQSLQNSDSLDAKQPPRAVRHRLPAERASVTHKFGLGGHEGYITVGLYPNGQPGEIFIRMAKEGSTVSGLMDSFATAISLALQHGVPLRVLCEKFAHTRFEPSGWTGNEQIGYAKSLMDYMFRWIEIRFLSGTQLDLFSGLAPQSSIPVQGTVSAPANTIHLNPSDPAATDVTVTTPPQQVFVTNGPNPDNKSAVILSEAQNLGIGSSPESAHMHHDQYEDRTAPRGGIAPDLQARSGLSGPSPLGPDPLTLEDRGIYHTSAALRSIVNMGDAPSCATCGAIMTRNGSCYRCGECGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0L2</accession>
    <name>E8X0L2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1917</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1917"/>
    <dbReference type="EnsemblBacteria" id="ADW68963">
        <property type="protein sequence ID" value="ADW68963"/>
        <property type="gene ID" value="AciX9_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1917"/>
    <dbReference type="eggNOG" id="ENOG5032S8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1852365_0_0_0"/>
    <dbReference type="OMA" id="YHLREMA"/>
    <dbReference type="OrthoDB" id="1746457at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="138" mass="16643" checksum="331C5AD5FFF5C7E5" modified="2011-04-05" version="1">MTRSELLLLLLGKAKTNGFEFRRWYVRTLGLPWQNSKHAVETLAEERRYYALLFSHEFAENFWKAGEKMTFLVENQSFQRRMADGTIGIVHRKAYTRRTGRRDAWKYHLKELAVAEEPLRYMRRYLRVEDELEEEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U1</accession>
    <name>E8X0U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3109</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3109"/>
    <dbReference type="EnsemblBacteria" id="ADW70125">
        <property type="protein sequence ID" value="ADW70125"/>
        <property type="gene ID" value="AciX9_3109"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3109"/>
    <dbReference type="HOGENOM" id="CLU_3118376_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="50" mass="5650" checksum="1BD454B9F19CE123" modified="2011-04-05" version="1">MTELKARQFAEDWISRVQGSLILHAATGDCKPFERAMSVLTDLTKPSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0U9</accession>
    <name>E8X0U9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ArdcN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3117</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581447.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3117"/>
    <dbReference type="EnsemblBacteria" id="ADW70133">
        <property type="protein sequence ID" value="ADW70133"/>
        <property type="gene ID" value="AciX9_3117"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3117"/>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012069_0_2_0"/>
    <dbReference type="OMA" id="FKQWQTA"/>
    <dbReference type="OrthoDB" id="1509644at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArdcN" evidence="2">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="32366" checksum="B89089FF0CB68F0F" modified="2011-04-05" version="1">MTTTAIDSKKPTTKQELIAANVKLLNEQLEAGHSEALTDYLTAMSRFHSYSFGNVLEIARQMPTATRVAGFWAWKNLGRSVNAGAKGIRILAPIVGVRRKKGEEAQKDITKQNERVLVGFRNAYVFDISQTNGVDLPAMHEVSGDPGENIERLAAFIKGQGIQLVYNPKIAPALGMSYGGRIAILPGQSKAEEFSTLVHETAHEMLHKAERRTATTKTVRETEAEAVAFVVGKAVGLVNRTASADYIQLYHGNASLLAESLEVIQQTASVILGALEPAVASEETPQQQEEEPELQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X120</accession>
    <name>E8X120_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5666 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0818</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0818"/>
    <dbReference type="EnsemblBacteria" id="ADW67886">
        <property type="protein sequence ID" value="ADW67886"/>
        <property type="gene ID" value="AciX9_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0818"/>
    <dbReference type="eggNOG" id="ENOG5032R56">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095274_0_0_0"/>
    <dbReference type="OMA" id="ANTRLMK"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230148" description="DUF5666 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="3">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="265" mass="26926" checksum="C15C9441F5016844" modified="2011-04-05" version="1">MKAGTLIRRCFWTVVLVPALALGQVGTDQQPAVAMGAGRMVRGTITAVAPDHLTVKTERGEVFQVAVTPNTQVRKGRDPIKYADVHVGDGVGAMGEVDRPNKTVHAMFVTVVDAEQIKKAKEAMGKSYIAGKVTAIDEVKLTILRADGVTQVIQVDEDTSFKRGGRGMQMMMGDGGLGAGSGGGRRGQGAAGGAGAAPGGDGESITLGDVKVGDMVGGPGALKGGVFVPTELRVGEPGARRGGRRQGEDGAAAAGGAAKPAPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X160</accession>
    <name>E8X160_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0858</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0858"/>
    <dbReference type="EnsemblBacteria" id="ADW67926">
        <property type="protein sequence ID" value="ADW67926"/>
        <property type="gene ID" value="AciX9_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0858"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_0"/>
    <dbReference type="OMA" id="FTMRWVF"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW67926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="506" mass="55431" checksum="4A2A535F6C8B7DB6" modified="2011-04-05" version="1">MKVGVIGSGLAGLAAACTLAARGHKVTVFEKNPWLGGKAAQLAEEGFRFDMGPTILIQPSVLRKVFAEAGKRMEDYVPMVRLDPQWRCFFEDGSTIDLMDDTGAMAAQLEAIWPKMGAGYLKFLKQSEQLHSISDRFFFWRSIGSMRDTMDVKGAFDLKVLKDVMRMRLGKTVAEVIRESIPDPNTAQMLDHFVQYVGSSPDASPAILCAIGHMQMEEGIWYPVGGTRAVPEGLVKLGRELGVDFHTETSVARITSAGGKVTGLVTDAGEAHKFDAVVSNEDAVRTHRELIGGAVARTFEHKRKYEPACSGVVLYLGLNKRYEHLAHHDFVFSRDPHEEFHAIYELGIPAPDPTCYLAATAATDPASAPEGGEALYVLVHTPYLRPGQDWNEMFPGYRQVILDKLKRTAGLTDIEERIVFEAHLTPQDIHERYRVLDGAIYGISSHGVFNGAFKPANRSKELKGLYLAGGAAHPGPGMPMVMMSGWIAADSLDQDAQSNVLRAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1G3</accession>
    <name>E8X1G3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conjugation TrbI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3187</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbI/VirB10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581510.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3187"/>
    <dbReference type="EnsemblBacteria" id="ADW70198">
        <property type="protein sequence ID" value="ADW70198"/>
        <property type="gene ID" value="AciX9_3187"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3187"/>
    <dbReference type="eggNOG" id="COG2948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646844_0_0_0"/>
    <dbReference type="OMA" id="KNMNIAP"/>
    <dbReference type="OrthoDB" id="1674599at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16429">
        <property type="entry name" value="VirB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005498">
        <property type="entry name" value="T4SS_VirB10/TraB/TrbI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042217">
        <property type="entry name" value="T4SS_VirB10/TrbI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03743">
        <property type="entry name" value="TrbI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="424" mass="45252" checksum="744A153056E1561F" modified="2011-04-05" version="1">MMEPNETKSVATVPEQPEAKTPLRKSMPVVVALVVIVGLIGIANVSSLMSGNKKVAPQSALTMSPTTPNAQQVSSFETQQQNQAKHDAEELQRQQALAKAMQELQQEQSVPGPESAGTPPMTAAQREQIYGSSPNAPQQTSNMSEAQAEAKQKRLAVQKQAQDAQNSDTVAIDFSHEGASPLTAVKAAGLQATDKESGEEIAGKPQSKEAASTAPAKSDPMSSYSFDQYDGELYRIFEGTVLEGVVTNHIDGGLSGPILVMLTTDYYSHDHQQLLMPQGTRLIGSVQAVGNAQQRKMFVTFHRAVCPDGFSLDFDKYVGLDQIGTTGLATRVDHGYLMAFGAAAAIGGLGGLAQIGNNASILTPSAQIREGISEQSAAEGEQVLNHFLNRLPVITLKEGSRARVYIGRDILIPSYAEHRVNPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1H4</accession>
    <name>E8X1H4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_3198</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581521.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3198"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="ADW70209">
        <property type="protein sequence ID" value="ADW70209"/>
        <property type="gene ID" value="AciX9_3198"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3198"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_1_3_0"/>
    <dbReference type="OMA" id="SDSRFWG"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="9">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="283" mass="31974" checksum="2FB2B58840B9C4E7" modified="2011-04-05" version="1">MPELQRRPAPVFPDDPDRLPRPLPRPETPHHQDHHHHHPVGTLPAIQSLLYVLVVALFLITFTVQPIRIPSGSMEPTLLVGDFLLLNKQSTASSDADLPFLPPTSLNRGDIVVFHDPVDDPSVHLVKRIIALPGDRLHLRNGIVFLNGHPLREPYAVHRPAPSDVFRDNFPLLTAMDTNVNPDWWIRLRTLIHGGEITVPPASYFVMGDNRNNSEDSRYWGFVPRADIVGKPFIIYFSWKQPDPNTDPDADPDTRPADPTARSGLLTTLSHLARWDRTFQVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1K4</accession>
    <name>E8X1K4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581551.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3228"/>
    <dbReference type="EnsemblBacteria" id="ADW70239">
        <property type="protein sequence ID" value="ADW70239"/>
        <property type="gene ID" value="AciX9_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3228"/>
    <dbReference type="HOGENOM" id="CLU_1018483_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="273" mass="28876" checksum="857BEDA4D0B24F94" modified="2011-04-05" version="1">MDGEIIRADYVLAQNTLSDLASRNLQAKAIIRKFAQRHAVMDVAIGAAGFWGLAVPALLVAIAAQAPIIYQPMAKELAAIYNVEPDGNTGLVVSTGVIVGGVADIAGEFSTEFIGMIAAELITEAGFGVVAGFIPFIGGVVGAALDYIIATAMTWRVGTMVSIYYQNGGKWVGSRKNTYALAKEMTGGLNFGLEDLAAKFTGAKKPELNVNFDEIPVKIPQVRDTQTQAAKQMLGVLLKVVTSSQARSALRDKGFPEFIIDAAFLAMSNAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M1</accession>
    <name>E8X1M1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579265.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0872"/>
    <dbReference type="EnsemblBacteria" id="ADW67940">
        <property type="protein sequence ID" value="ADW67940"/>
        <property type="gene ID" value="AciX9_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0872"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_2_0"/>
    <dbReference type="OMA" id="GGEFYER"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="312"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="460" mass="50577" checksum="10EA2B6F40843EF0" modified="2011-04-05" version="1">MRALRTTFIGIDHRLLPDPRKQPKVQASSPSILRSPRALDHTSLSPYDDAGNIAEDLELVTTQLLSIEAGALNFCPALETRFEHDTRRARSHRLWLEGAIAIVAMNLALILDCLLVHDHGWAVIARETAMITPVALTVNMIVKRNPPRWLREGSIAVSMVIICAMNIYAEGNTTTASSFFGIIGLFVTALFVGVVMRLRFPFLCASLAGMALVGSWSLNHSPALLHAERVMGSSLTLLALGLIFLAGMSLENSERRGYLSHMIADLQSKALTRANQELQRVSSIDKLTSLPNRRTLEERLASMWVACHQLNDFLSVVLIDVDHFKSINDTFGHLSGDQTLRAIGAVLLHGLRNQDDLAGRFGGEEFLVLLPHTGPTEAIEVADRIRTLVAGAPPRSRRTDDKQDPWPVTISCGVSSCNPRSGFEIDDLLRLADAALYNAKRSGRNRVEYQACTAHDPEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1M4</accession>
    <name>E8X1M4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0875</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0875"/>
    <dbReference type="EnsemblBacteria" id="ADW67943">
        <property type="protein sequence ID" value="ADW67943"/>
        <property type="gene ID" value="AciX9_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0875"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_0_0_0"/>
    <dbReference type="OMA" id="WRAKHFG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="157" mass="17992" checksum="A1AFE87E8C4EEFE6" modified="2011-04-05" version="1">MRIEAPVERCFDLARCVEVHLLGTERTGEEAVGGVVTGLIGAGEWVRWRAKHLGVRQELTSRITGFERPAYFQDTMEEGAFRFMQHDHFFRTLADGATEMRDRFCFSAPVPVVGWIVERVFLRGYMERFLLRRNEILKEVAEGDGWRAVLGDRTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1Q9</accession>
    <name>E8X1Q9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0911"/>
    <dbReference type="EnsemblBacteria" id="ADW67978">
        <property type="protein sequence ID" value="ADW67978"/>
        <property type="gene ID" value="AciX9_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0911"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_1_0"/>
    <dbReference type="OMA" id="KGMSQGD"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="15288" checksum="C219C7E14ACF77FA" modified="2011-04-05" version="1">MADMQIVLPQQADVPVKSISMNIGTTIRDYRLQRGMSQGDIEKRTGLLRCYLSRVENGHTVPSLETLQKIAGALDLQLSQFFAEDQVQKEVSTLNLSEEEIRFLTQVQRYSAHLSDSDRRLLLAMVRKFASTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V1</accession>
    <name>E8X1V1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580429.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2067"/>
    <dbReference type="EnsemblBacteria" id="ADW69112">
        <property type="protein sequence ID" value="ADW69112"/>
        <property type="gene ID" value="AciX9_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2067"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_0"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="124"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="257" mass="26510" checksum="051ECAC539784348" modified="2011-04-05" version="1">MNPTTLLALLAEVERGTLTPESAATRLASMPFEVLNTDQTEEARIDHHRLLRTGLPEVIYAAGKTPAQTANIFATMAATGTAVLATRATQAHYEAVAALTPTAVYQATARCITQQPTQHSAPKGHIAVLCAGTSDLPVAEEAAVTAELFACKVTRLYDVGVAGLPRLLAVRPQLMEADCVIVCAGMEGALPSVVGGLVAVPVIAVPTSVGYGASFGGTSALLGMLNSCSPNVTVVNIDNGFGAAYTATMIARATHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1V9</accession>
    <name>E8X1V9_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ordered locus">AciX9_2075</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580437.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2075"/>
    <dbReference type="EnsemblBacteria" id="ADW69120">
        <property type="protein sequence ID" value="ADW69120"/>
        <property type="gene ID" value="AciX9_2075"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2075"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_0_0_0"/>
    <dbReference type="OMA" id="TDHGHPT"/>
    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="469" mass="52989" checksum="68C67C2E22FF16D3" modified="2011-04-05" version="1">MLHEHRLFPADGAARAIAVKLYETIKDAPIISPHGHTDPQWFAENKPFANPTALFLQPDHYIFRMLYSQGISLESLGVPQAGVKGDASVGVDPREAWRIFAKNYFLFRGTPTRLWLDHSFSTLFGFTERLSEKNADEYYETIDKALKTPEFLPRALFEQFNIEVLATTDAATDPLKFHAQIKESGWKGRVVPTFRPDSVVDAEFIGFKENLQKLGEMTGEDVSNFKGYLNALRSRRAFFKSMGATATDHGHLTAMTADLPADEAGRLYERVFAGKMQAGDVELFQAQMLTELAGMSVEDGLTMQLHPGSVRNHNLNVYEKFGRDKGADIPSPTEYVRSLRPLLNKYGNEANFTFILFTLDETSYSRELAPLAGHYPCLRLGPSWWFHDSPEGMMRFREQATETAGFYNTVGFNDDTRALLSIPARHDVARRVDAAFLGRLVAEHRLDEDEAFELIQDLTVNLVKKAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X288</accession>
    <name>E8X288_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0953</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0953"/>
    <dbReference type="EnsemblBacteria" id="ADW68020">
        <property type="protein sequence ID" value="ADW68020"/>
        <property type="gene ID" value="AciX9_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0953"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_1_1_0"/>
    <dbReference type="OMA" id="WLRAFFV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="92" mass="10935" checksum="F09C9FFDC4C2371D" modified="2011-04-05" version="1">MIRTFADRETERIFSRERSRRFSGLEKVILRKLSALHAVRLLSELAVPLGNHLEALKGDRKGQHSIRVNQQYRICFRWEEPNAFEVEIVDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2A2</accession>
    <name>E8X2A2_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0967</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21528"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GppA/Ppx family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579358.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0967"/>
    <dbReference type="EnsemblBacteria" id="ADW68034">
        <property type="protein sequence ID" value="ADW68034"/>
        <property type="gene ID" value="AciX9_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0967"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_4_2_0"/>
    <dbReference type="OMA" id="RISEGCY"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006793">
        <property type="term" value="P:phosphorus metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022371">
        <property type="entry name" value="Exopolyphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03706">
        <property type="entry name" value="exo_poly_only"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="5">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="57853" checksum="8542EDF2C329298D" modified="2011-04-05" version="1">MPTFAAIDIGSNSCRLKIASVVQHKLKTLHEDREVTRLGESVFQTGVISPEAMADTVKALKRFRKACQTHVCDKVRVVATSAMRDARNSQAFREWVKSSTGWDVEIISGLEEGRLIHLGVVTYEPGAKGRVVLIDLGGGSCEVTLSDGGRVKEMVSLPLGAVRLQQEFLQQDPPAKEDVGRLKQFIDRELKRAEKRLGHPQVQLVVATSGTAAALAEASVAMGIGKVPVKKTVPKGFEKVKVMEAATEDVRRLADKLLKLNNTQRAAVPGINARRSEIIVGGAQVYATLLERFGFKGFRYSPLGLRDGMLAQMLGEVDLRAEVHAKIESERWSGVLEVCKRYGIDQKKAEPVRAHVVQLFDSLQRVHELPMEYRLWVQAAAMMQEVGKFMNHQGHHRHTQYIVANSEIFGFSPEQRLIVSAITRYLGKTRPDAMDRTMRLLPVEEHQNVQRAVVLLRLAAALNQDRASAVVGLKTTVYPKRIVMDILPGRGGAALEGWALKKEANYFREVFRRELFVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B0</accession>
    <name>E8X2B0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0975</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579366.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0975"/>
    <dbReference type="EnsemblBacteria" id="ADW68042">
        <property type="protein sequence ID" value="ADW68042"/>
        <property type="gene ID" value="AciX9_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0975"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_4_4_0"/>
    <dbReference type="OMA" id="DIGTGTM"/>
    <dbReference type="OrthoDB" id="2014241at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="128" mass="13638" checksum="BDB5E5AC511847E5" modified="2011-04-05" version="1">MSEDNGTSGLGWFLAGLGIGALVGVLYAPKSGSETRSDLIASAQDAKEKAAALAQQGVDRANGYVDQGKQVAGEYVDKGKEYYERGRSQWTQYVEKGKDLVQDQQDKVQAAIDAGKEAYASKTAEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2G5</accession>
    <name>E8X2G5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2145"/>
    <dbReference type="EnsemblBacteria" id="ADW69189">
        <property type="protein sequence ID" value="ADW69189"/>
        <property type="gene ID" value="AciX9_2145"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2145"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_2_0"/>
    <dbReference type="OMA" id="YDVGSRH"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="247"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="509" mass="55897" checksum="6EE719B3A3B0E20F" modified="2011-04-05" version="1">MLALGSVAALVTVGVRAQDLASFEKRTTVKVLPNGLTLIVCERPEAPVFSFYTLVDAGSADDPGGQSGLAHMFEHMAFKGTDEIGTTNYTAEKVALAKVETAYAAFDAEFRKRVGQDAGRLASLKKTFDEAQAGAQKYVIPNAFPQLAEQNGAEGLNASTEEDSTQYFWNMPSNRLELWAYMESGRIGHPVEREFYKERDVVQEERRMRIDSSPTGRLVEQMLATAYVAHPYGRSGVGWESEISQVSATEAEAFHKKYYVPANIVVAVVGDLKASTAMPMLEKYFGKIPAGPKPEAMTTVEPVQTAEKSVVIHEQTQPFYLEGYHRPDYRDPDDAVYDAITDIVSNDRTSRLYKSLVRDQKIAAVAQGFSGFPGQKFPGLFAFYAVPLPGHTPEELGVSIHKELERLKTEDVSDAELERYKERTKADKLSGLADNAGLANSLAEYQTRYGDWREMFREIAKIDAVTKADIKRVANKTFVASNRTTAEIVYDAPKAGAPKSAAAPAGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2N3</accession>
    <name>E8X2N3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SNF2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3321</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581642.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70330">
        <property type="protein sequence ID" value="ADW70330"/>
        <property type="gene ID" value="AciX9_3321"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3321"/>
    <dbReference type="HOGENOM" id="CLU_1426164_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="190" mass="19738" checksum="DBC5B70C044AE17A" modified="2011-04-05" version="1">MSLDANGKPRQYLRIEQSQYDAEIAAAEERGRASATTSPAAAPAAMPIVAAPAASLPASMSEPERLAAIDALGFSAEFPELFKAAKEQGLSVEATSMKLIAAIRARGANPKEMAEKITAHVKAAQAQGRRITFVQAANEIEEAAAGGISAGSEARDLSKRLEDHIAKAKAEGRTIGPAQAAAELEAQGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2P8</accession>
    <name>E8X2P8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3337</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70345">
        <property type="protein sequence ID" value="ADW70345"/>
        <property type="gene ID" value="AciX9_3337"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3337"/>
    <dbReference type="HOGENOM" id="CLU_3062062_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="5641" checksum="E5D0FBAC1A42BAFB" modified="2011-04-05" version="1">MRKLMFWTTVLSGAAAAYLLFKKGVPAGTIASEVIAHPIGTLIHELESTSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U4</accession>
    <name>E8X2U4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3384</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581703.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3384"/>
    <dbReference type="EnsemblBacteria" id="ADW70391">
        <property type="protein sequence ID" value="ADW70391"/>
        <property type="gene ID" value="AciX9_3384"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3384"/>
    <dbReference type="HOGENOM" id="CLU_2273410_0_0_0"/>
    <dbReference type="OrthoDB" id="14444at57723"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="102" mass="11762" checksum="20C7E25EB051BFFA" modified="2011-04-05" version="1">MNDKRNLPAFASEAEEAQWWFDHREERDVEFAEAIRTGRAQTNMVRNRMAAREQASVPTTITIQDADAMTAARLAERNGMELSTYLHDLMHRAIQRENEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2V8</accession>
    <name>E8X2V8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6249 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1029</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579415.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1029"/>
    <dbReference type="EnsemblBacteria" id="ADW68092">
        <property type="protein sequence ID" value="ADW68092"/>
        <property type="gene ID" value="AciX9_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1029"/>
    <dbReference type="eggNOG" id="ENOG5032RHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1813066_0_0_0"/>
    <dbReference type="OMA" id="FILHERD"/>
    <dbReference type="OrthoDB" id="1844512at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046216">
        <property type="entry name" value="DUF6249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19762">
        <property type="entry name" value="DUF6249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6249" evidence="2">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="142" mass="15361" checksum="CE84E54403A8B9B7" modified="2011-04-05" version="1">MLFSPFVVPLGAFLVAIVAIAGGLFSQAHARRVKADQRMAMLARGIPLVEIEAVLKTAKDEEERPVKDPMRSLGNARRTAVVLISSGLGLMLFFAVISFILHERDVMAGAAIGLIPLAIGLGFVVDYQLQKREMARFGLEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X382</accession>
    <name>E8X382_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2268</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580622.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2268"/>
    <dbReference type="EnsemblBacteria" id="ADW69306">
        <property type="protein sequence ID" value="ADW69306"/>
        <property type="gene ID" value="AciX9_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2268"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399504_0_0_0"/>
    <dbReference type="OMA" id="WNLRFVR"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234133" evidence="1">
        <location>
            <begin position="28"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="757" mass="81257" checksum="4330A329F36124B7" modified="2011-04-05" version="1">MFRRFALKSALLTFLSPLLFSATFAAAAPWLPFGPDGGDARKFAIDPHDHTHLYLGTANGWIYETHNSGANWRRLSRVGKRDDLVIDNIVVDPSDPKHLIAGAWVGSDGGLFITYDGGATWTSQAEMRGQSVRSLTSAPSDPKIIVAGTLKGVYRSTDGGRRWRLISPPDSTEIHEVESVAIDPKDPNIVYAGTWHLPWKTVDAGENWDSIKQGIIDDSDVFSIIIDPNSPKVVYASACSGIYKSEDAGTQFHKIQGIPSTARRTRVLLQDPSNLDIVFAGTTEGLFRSTDAGKQWQRTTTPEIIINDVFVDPTDPHHVLLATDRGGILASDDGGDTFRSSNGGFSARQVATLKRDNLHPATIFVGVVNDKEWGGIFQSDNGGIDWAQRSEGLKGRDVFSLGQSPDGTMIAGTAHGIFRLDRDAAVWNQVEQTPEAIAADNAAVAPPEIRAAVSINRNQFAQRNNVKPSATHAAPHTTALKNSKGKAFQHPPLHKAAKPLPNSPAARKAKLLAAKKHTAAPSKRTKIVVVKKPQPVAPPVKELTATAAPKPHFFDGSVFAITTSDQTLLAATSAGLLASSDQGVSWKPAGPPDSAEWRYLASAKNNVVAASLHGVQFSPDSGADWSPIRMPEKITLVTATAVEPSGEIWVGGPEGIFVSSDAGNTWTTPKNLFTNSVTSIYYDDATNRILVTAVGSGSAAFMVQLPQKTVTYTDTGWNLRFVRPVGDHLVAATFFDGIVIQPKMMSGSAPKPETAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X391</accession>
    <name>E8X391_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_2277</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580631.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2277"/>
    <dbReference type="EnsemblBacteria" id="ADW69315">
        <property type="protein sequence ID" value="ADW69315"/>
        <property type="gene ID" value="AciX9_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2277"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137298_0_0_0"/>
    <dbReference type="OMA" id="WFSFRRP"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="164" mass="18238" checksum="AB6B54B18CEED044" modified="2011-04-05" version="1">MDTLTPIVTPTPEPHGPFAALRRVFPTGEVIRFLLVGASNTLFSYALYAACVRFYGHLMPTHGQPLIADIASITSKPIGITVAFLGYKHFVFRTHGNYLKEWLRCFAVYGVSTPVELVILPVATKLFLLTALTHPYAPYLAGIVNSVVIASYSYFAHKKFSFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3A4</accession>
    <name>E8X3A4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3399</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3399"/>
    <dbReference type="EnsemblBacteria" id="ADW70405">
        <property type="protein sequence ID" value="ADW70405"/>
        <property type="gene ID" value="AciX9_3399"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3399"/>
    <dbReference type="eggNOG" id="ENOG5032C54">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2464708_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9993" checksum="D2DCA3A15B89DB71" modified="2011-04-05" version="1">MTGLAVGRSFALMTKTDDFDQLLSNYRQAVDAWVEAIHAEEELATDDHSMVQMEAWDTAGLALHDVELTAKKARDEYKNALRRKNYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D2</accession>
    <name>E8X3D2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3427</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581745.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3427"/>
    <dbReference type="EnsemblBacteria" id="ADW70433">
        <property type="protein sequence ID" value="ADW70433"/>
        <property type="gene ID" value="AciX9_3427"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3427"/>
    <dbReference type="eggNOG" id="ENOG502ZADD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080735_0_0_0"/>
    <dbReference type="OMA" id="YFFVYWI"/>
    <dbReference type="OrthoDB" id="1970701at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="295" mass="32718" checksum="763C4FE360D3EC3C" modified="2011-04-05" version="1">MTKTAIIDLISYVEPLACLAALILMQRRRQIVHFKYLSGFLLTRILSIVIMLPLLHRLGGRISIHASYLSYFFVYWISYAIEAMLGLGMVYDVYKLAMAPLRGLQTLGMVMFRWATAIAVAVAIGMAFGPNVSSHGFLVRAVTQLQQTQSILTLCLLLFVALAIRPMGLSFKSKIFGVSLGLGILASMNLIGSAWISQAPSMSSTFNLINSIMFCIVISTWMTYFALPEPKRRMIVLPTTSPFLRWNQISMALGDEPGFVAVGGIHPDMFAPAEVEIMRRASKKMEPLALRETQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3M7</accession>
    <name>E8X3M7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpD</name>
        <name evidence="12" type="ordered locus">AciX9_1155</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579541.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1155"/>
    <dbReference type="EnsemblBacteria" id="ADW68218">
        <property type="protein sequence ID" value="ADW68218"/>
        <property type="gene ID" value="AciX9_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1155"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_0"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="150"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW68218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="479" mass="52053" checksum="51361A88B777B378" modified="2011-04-05" version="1">MADNVGKVISISGPAVDVQFEEKNMPPIFQALRITGEGFKTPNPVNVVVEVQQHLGEGRVRCIAMVATEGMVRGMNAHDTGNGIMVPVGRETLGRVLNVLGEPVDELGPVNAKVHMPIHRQAPAFDEQSTSEEMFETGIKVIDLIQPFLKGGKIGLFGGAGVGKTVVIQELINNVAQQHGGFSVFAGVGERTREGNDLWHEFQESGVIDINDFNKSKAALIYGQMTEPPGARLRVALTGLTVAEYFRDEEGADTLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLATEMGELQERITSTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRPLSELGIYPAVDPLASTSRILSPRVVGQEHYDVAQGVKRILQRYKDLQDIIAILGIDELSEEDKITVARARKVQRFLSQPFHVAEIFTGIPGAYVKVADTVRSFKEIIEGKHDHIPEQAFYLKGGIEDVQAAAEKMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3R3</accession>
    <name>E8X3R3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2304</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2304"/>
    <dbReference type="EnsemblBacteria" id="ADW69341">
        <property type="protein sequence ID" value="ADW69341"/>
        <property type="gene ID" value="AciX9_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2304"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26774" checksum="A7331825AE1ACA1D" modified="2011-04-05" version="1">MAEVITKLANPAPKMTRDECAVISLDGVSREYAGRTGVVRALDSATFSIVAGEWVAITGPSGSGKSTLVNMLGCLDRPTCGELKIDGTDVASMTAGELDRFRADKIGFIFQQFHLIPYLSALENVMLAQYFHSMTDQEEARAALVKVGLGERAEHLPSELSGGEQQRVCIARALINNPPILLADEPTGNLDHANQKIVAQLLRDLHLAGHTIVMVTHDPEMAALAQRRIALSHGTVFCHPVGGIVRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3T0</accession>
    <name>E8X3T0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2321</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580674.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2321"/>
    <dbReference type="EnsemblBacteria" id="ADW69358">
        <property type="protein sequence ID" value="ADW69358"/>
        <property type="gene ID" value="AciX9_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2321"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005632_1_0_0"/>
    <dbReference type="OMA" id="HGGWNSD"/>
    <dbReference type="OrthoDB" id="520387at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011429">
        <property type="entry name" value="Cyt_c_Planctomycete-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011444">
        <property type="entry name" value="DUF1549"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022655">
        <property type="entry name" value="DUF1553"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07635">
        <property type="entry name" value="PSCyt1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07583">
        <property type="entry name" value="PSCyt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07587">
        <property type="entry name" value="PSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230646" description="Cytochrome c domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="39"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119814" checksum="B2425C0865BCEC8E" modified="2011-04-05" version="1">MKKLWLAGTFTALTLSLTAGAQQAAPADKIHAAALKPAGAGGDQQKYFEDKVRPVLAQNCYKCHTSEAMGGLRLDSRERVLKGGDTGPALIPGAPEKSLLIEAINQTGDLKMPPKGKKLTDGEIASLTEWVKNGAAWDAAESTKPITATLTAAAVKGGAGEEYFENNVRPILAQKCGTCHEDRSSGGLRMISREALLKGGDSGPAIVPGDPDKSLLLTAVHQTTELKMPPKGTKLSDQEIQSLTDWIKMGAPWPASTVAVREEGKQITDEMRAWWSFQPLKAPAIPVNKNAGWAKSDIDHLVLAKLEAKGMSPAAAADKRTLIRRATLDLTGLPPTEEEVTAFEQDKDANAYEKVVDRLLASPRYGERWGRHWLDVARYADDDIRGLDPRGRGYMPLDGAYVYRDWVVRAINSDLSYDKFVKMQLAGDLMSKKPTPDELEATSFLGAAPWIWDQAEPAQGRADERNERIDAVTRGYLGLTVACARCHDHKYDPILAKDYYALGGVFASSTYKEYSFVPDEEVTYWHDKFNKADKMDEAVQAYNKTESEQLAKAFASESSAYMVAAWRVSGKPKMKVEDVAEKDKLDPEQLDRWVKFLGKKQTFYPYLHDWQMMIAQGGTEDQAKYLGDAFQGLILDLEMEQKQLEEDNKKIEAKADVPTRRKKEAKPNEFDTYDEFCPGCTLELKVMTPERANLYSDLFVRALSSDSEGRGEPGLFAYRGWALRRRLGPTEQQYLADLEVQGKKMHKDMPEQYPFVHGFTDRPKAVNIALNLRGNPHALGPEIPRAFPEVLGAPGKKPYTEGSGRLDLANDIVASPLASRVWVNRVWKWHFGTGIVNSPDNLGKVGDPPSDPELLDYLAISFQKNGMSLKKLQKEIMMSATYQQSSKESPLAKETDPDNRLYSHFSMQRLDAEQLRDSILFVAGDLDTSKLGGPAKPLGTDNTRRTLYAKVSRFRIDPFLQEFDFPNPTFTAEQRFSTNVPVQRLYFMNNAFVYSQAGKLAARVYAKGDDAARIKDTYQILFNRAPTAEELQLGLTFLKNTPERPGYLVNQEPLTAWKQYARVLFSSNEFEYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3X6</accession>
    <name>E8X3X6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Formate dehydrogenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">AciX9_3479</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581795.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3479"/>
    <dbReference type="EnsemblBacteria" id="ADW70484">
        <property type="protein sequence ID" value="ADW70484"/>
        <property type="gene ID" value="AciX9_3479"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3479"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_0"/>
    <dbReference type="OMA" id="NVGTDIP"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="16">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="15">
        <location>
            <begin position="278"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADW70484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111960" checksum="4DF077EB0D6AA239" modified="2011-04-05" version="1">MVATKSLLNTPLDITPDTTIMVNGEAVAAHAGEHLIEALNRHATALNVKGTPQVCYVPQMGPIQSCDTCMVKVDGKLVRACGTPVTSQMKVETEGYEVDVAQREAFDRILQNHMLYCTVCDNNNQNCTVHNATADLDVKHQARPYMEKPYEKDMSNPFYRYDPNQCILCGRCVEACQSVQVNETLTINWESEHPRVLWDGGEKIEGSSCVSCGHCVTVCPCNALMEKTMIGHAGYLTNIPPKVLDDMIEVVKGIEPPIGYGPILALSEMESEMRHQRVKRTKTVCTYCGVGCSFEVWTRDRHILKIEPTHGPANGISTCVKGKFAWDFINSPDRLTQPLMRQGDTFVPITWDAALDLIAEKWGKIKEEHGPDALAFIASSKCTNEESYLMQKLARQVVGTNNIDNCSRYCQTPASMGLQRTVGYGADSGSISDIEMASLVIIVGANSAESHPVLATRIKRSQKHRGQRLIVADIRKHEMAERADMFIQPNPSTDEVWLSGVAKYILDHNLAKMAFVHKWVNKFEEYAKSLEPFTLEYVEQVTGLSQDTMITLANEIAAAPTVCILWAMGVTQHCGGADTSTCISNLLLLTGNYMRPGTGAYPLRGHNNVQGASDFGSMPNIFSGYQKVDDAEIRGKFEADWGCTLPVNKGLDNREMIEAIHAGKLKAMYIKGEDTITSDSNANDVGEALRKLDFLIVQDINFSVTCEYADLILPASPSLEKDGTFVNTERRIQRLYKALEPLGESKPDWVILQMIANRLGAGWDYKHPSDVMVEVARLTPSMAGVTYERLEGFKSLQWPVAKDGTDTPLCYTEKFALPDGKATFWPLVYVPPSEEVSAKYDLHLNNGRLLEHFEQGSMTYRSPGIKEITPENFVEVSPELAAERGIATGRYVQLTSPYGRVRVQVLVSDRVKGKQLYMPLNSVAEPVNKLTGSHTDRATHTPAFKETSVEMTVLPEMGENPLPRKNFRYGTRHPQMGLEIERKWALPGYHLPGTKESDKLVQIKSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4A2</accession>
    <name>E8X4A2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0071</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578491.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0071"/>
    <dbReference type="EnsemblBacteria" id="ADW67162">
        <property type="protein sequence ID" value="ADW67162"/>
        <property type="gene ID" value="AciX9_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0071"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042661_0_0_0"/>
    <dbReference type="OMA" id="TYLWFSQ"/>
    <dbReference type="OrthoDB" id="1778971at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="444" mass="50542" checksum="B112A40938F9EFAF" modified="2011-04-05" version="1">MSSGYVQHEADHGHGHHGPKVLPEKLNSPEVLTVWRTRALMIAVIAAVISLVFLFVPGGKSHMLRAYLLGFMICFSFAGGGLVLLMLQYVTGGKWGLLLRRPLEAMTRTIGLVALFILPIGFFMKHLYQWARYPSIADERNALAHGWIDKEQAWTDISKHAMFNPTSAIIQTIVVFAVLGTLTYILNKWSLERDADPAAGSIASYDRWRVRFENLCGPGIFIYVVCLTDAALLWIMSLDVTWYSSIWGLKFLVGQGYAVLALGILTVVKLSKTEPMKTLLRTTEQHDLGKFIFAFVMLNIYLTFAEFLIIWSGNVPDEIPWYLSRIRGDWWWICTLDFVCHWLIPFCLLLSRDLKRSKKRLTAIVSFMLLARCIDMFWIIEPNFKDAASNLHLAGNFGILAYLTVPVCVIALWWAYYCTQLMSRPLVNVNDPHLEEILEPEHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E1</accession>
    <name>E8X4E1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1205</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579591.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1205"/>
    <dbReference type="EnsemblBacteria" id="ADW68268">
        <property type="protein sequence ID" value="ADW68268"/>
        <property type="gene ID" value="AciX9_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1205"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023843_1_0_0"/>
    <dbReference type="OMA" id="DNSQGWI"/>
    <dbReference type="OrthoDB" id="1201303at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="282"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="662" mass="71254" checksum="C5051295EE368DFD" modified="2011-04-05" version="1">MIRIFQQDNKFVKLAIASFITVALGAMVITLVPGIFDNVDSGGSGVNYATVHAPGLFGRFGGDSEPVLQTEVTRAATQQLEQQKLPPMLMPYIESRVAQQLVQEAILKLEADRLGLQVADSDLLRELHQGQIGQILFPNGQYIGDDAYMNFVQNQLNMTRGDFEILVKKEMEVARLQALITGGVTVSDNAVRDSYRVSGTKVKFDYAVITSDTLRATVNPSDSDLQTFFKTNQARYATAVPESRKLNYFAFGADQIPGGKPQVTDADLQTYYNAHLAQYQVKDQAKVRHILIAVPAGADARTDAAAKAKADDLLKQIKAGGNFADLASKNSDDPGSKANGGELGFLSPGQTVPEFDKASFSLKPGQTSDVIKTKFGYHILQVEERQNAHTKPLNEVKAEITPIVEQQKFGNAEAAYAKSLSDEARKNGIDKTAAAHGLHATTTDFVGKDGVVPGVSDSTALLAQAFTTTKKGDPISVSTGDGFAIFQVVDIQAPHAPTFDAYKSHILDDYRAEKVPQLLNEKLNKLDARAKELNDLHKAAAELNIPVKSSDLVGKDGQVPDLGAMSGPGAPAFDLAKGTVSNPINTGSNGIVLVVTDKQEPSADDIAKNFTATREGLLNERREEVFRLYLGTLTEKYQKSGGIRYAKKTNAPGAPGSSPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4E6</accession>
    <name>E8X4E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1210</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579596.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1210"/>
    <dbReference type="EnsemblBacteria" id="ADW68273">
        <property type="protein sequence ID" value="ADW68273"/>
        <property type="gene ID" value="AciX9_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1210"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003772_1_0_0"/>
    <dbReference type="OMA" id="GWLFYAS"/>
    <dbReference type="OrthoDB" id="312576at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230219" evidence="2">
        <location>
            <begin position="30"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="913" mass="97275" checksum="EBC24B544D93A107" modified="2011-04-05" version="1">MKKVYSGLFRSAALAGVVGLSLSGVGAVAQVAAVERGFVSPPNEAKPMVRWWWFGPAVEKPEIRRELEQMKADGLGGAELAFVYPEVLDDAAKGLKNEAFLSPGMLGAVTYAQAEGRRLGLRIDLTLCSGWPYGGPATTLEEAAGRLRMVALPLANGALPMVKLGDGDQVVGRFVAQGDAKKWDAATAKPVTDGAVPAGSSSSSDRVALFFVAGHTKQMVKRAAVGAEGYVLDPFSKEAVATHLKAVGEPLVKAFGGTPPYAIFSDSLEAYGADWTPKLPEEFKKRRGYDLMVHLPELWAGGTAAADKVRHDYGRTLTELVDDNYLVQINDWAKAHGTKFRSQTYGEPAVSLSSQRLVDLAEGEGPQWRAFSTLRWATSANHDFGKTVTSGETFTWLHSPVFRATPLDMKAEADIDFIMGENQLIYHGWPYSAPQVGEPGWSLYAAAVFNDHNPWHPVMPAVSSYIGRMSYLMRQGKAANQVAVLLPTDDAWAGFSPGKVTVSGAMAKLISPGLMSAVLMAGYNLDYTDADAVNRVGVGHPVLVLPPTDRIPVETLRKIAAYVKGGGKVVAVGRVPSMDEEGAASAEVTRLAGELFGGEHFVADVGGLGEALRKLAAPDLLMTPGGSEAVGFIRRKLTDGDVYFVVNTSNEAVKATARFGTSYKVGAQWNPETGAEVGMVSAADTAIELAPYESAVYVFSGRPAGNAVGAGEFTAVNDLSRDWKVTFTSAAKTVNEAALTDWMADPATLHYSGEAVYSREFTLAAAPKGPVYLEIEGGKALPGSPSSPPEHRALGADGLPDPKVTGTGPGMHAYFEPPIREAALVTINGNAAGALWHPPYRLDVSKLLKPGVNHIEIKVYNTALNAWSALPPHDYKPLVEKYGDRFQMQDLNRVQALPSGLLGSIHLVTQGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4H3</accession>
    <name>E8X4H3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1237</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579623.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1237"/>
    <dbReference type="EnsemblBacteria" id="ADW68300">
        <property type="protein sequence ID" value="ADW68300"/>
        <property type="gene ID" value="AciX9_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1237"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="QIISEVW"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="28338" checksum="9F45C21E8FB764EA" modified="2011-04-05" version="1">MTTPTDSPLILLVEDEEHLAQGLLFNLEAEGYRTRHFADGAEALTWLLETQDPIGAILLDVMLPGKDGFEIVSTLRDQHLYFPVLMLTARSNPQDILEGLNAGADDYLPKPFDLEILLARLKTMLRRAAWQRTTPDAPEPDPAPSKDVYLFATREIHFDTLELVVPNRPTIHLTLMEADLLRFLTDRAGQIVPRKDILEQVWRVHEDTDTRAIDNFIVRLRRYIEDDPADPKHLLTVRGIGYRFLPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4S4</accession>
    <name>E8X4S4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3559</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581874.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70563">
        <property type="protein sequence ID" value="ADW70563"/>
        <property type="gene ID" value="AciX9_3559"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3559"/>
    <dbReference type="eggNOG" id="ENOG5032P0B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174065_0_0_0"/>
    <dbReference type="OMA" id="IAMIWGA"/>
    <dbReference type="OrthoDB" id="2060152at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="70" mass="7507" checksum="B62CD4365329E960" modified="2011-04-05" version="1">MGNRKSVVLSLVLTFFLGPFGMLYSTVPGALVMLVLYVALGIVTLGWALAVLHPIAMIWGAVAADRANRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W1</accession>
    <name>E8X4W1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3597</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581911.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70600">
        <property type="protein sequence ID" value="ADW70600"/>
        <property type="gene ID" value="AciX9_3597"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3597"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_3_1_0"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="10470" checksum="7A126CC5FF792876" modified="2011-04-05" version="1">MPLYEYECTACHRHTEKIQKFSDPEITVCPFCAGPLQRVISAPAFSFAGGGWYADGYGSKKPSAASDTSTTTPAATASTPAAAPAAAPAAAPSAPASTSSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Y7</accession>
    <name>E8X4Y7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0089</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0089"/>
    <dbReference type="EnsemblBacteria" id="ADW67179">
        <property type="protein sequence ID" value="ADW67179"/>
        <property type="gene ID" value="AciX9_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0089"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023846_0_0_0"/>
    <dbReference type="OMA" id="SHQRIYG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="243"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="264"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="730" mass="81077" checksum="6A93ABB0114E8340" modified="2011-04-05" version="1">MQFLIASTFQDSLGRLQPAEQNAAKLAAIELQMNPAHPGLQMHKLDRARDKSFWSARVSDDLRMILHRTDASCLLCYVDHHDSAYAWAERRKLTVHPKTGAAQMVVLQETVQHIIVPRYVPEEPKAKTKSLLLLAGASDADLLRFGVPEDWLDTVRNATEETVLDLVEELPEEAREAILSLATGVRPAPSPVAGALVADAGSSANAEAVAFTHPDAQRRFRIVSNLDELQAALDAPWEKWTVFLHPGQRAIVERNFNGPARVTGSAGTGKTIVALHRAVYLAQNNPSSRVLLTTFSEVLANALDNRLRVLISNRSWLGEQIEVLPFEAVARRLYASNLAPLYGPVTIASAESILTHVRAAMEAVPSCLFSERFLMSEWAQVVDAAQLRSWEAYRDYSRAGRRSRLREPQREVLWQVFDKVLKSMEDQREMTTAEMFVRLAKHYAHGAAPPFDFAVVDEAQDISMAELRCLGALGSGRSNALFFAGDTGQRIFQQLFSWKSAGVDVRGRSSNLKVNYRTSHQIRHAADRLLASEVTDGDGSVEERRGTVSVFNGPSPELVQLNDEISEARFASAWLVARREEGHQSDEMAIFVRSAAQLDRAEAAARATGMQFSHLVAHANVSPGLLTVCTMHLAKGLEFRDVVIMACEEDVLPDPERIGSAGDASELDDIYNSERQLLYVACTRSRDRLLITSAHASSEFIEDMRTMTTNSTHEQRKQWRIQSTTSAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5E7</accession>
    <name>E8X5E7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pvc16_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580810.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2459"/>
    <dbReference type="EnsemblBacteria" id="ADW69494">
        <property type="protein sequence ID" value="ADW69494"/>
        <property type="gene ID" value="AciX9_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2459"/>
    <dbReference type="eggNOG" id="ENOG502ZC8H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052029_0_0_0"/>
    <dbReference type="OMA" id="WSVFFQT"/>
    <dbReference type="OrthoDB" id="983165at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="439" mass="46471" checksum="B5A2E12A954BCFBF" modified="2011-04-05" version="1">MSTALALASVSYVLVDLLNNGLIDHDISSVAGDVSVTALSPDQIDASSPTNSQLNLFLYNVTQNESWRNDNYPSRNFQGDRISNPPLALNLHYLLTAYGAEPFHAEILLGYGMQLLHENPVLPRDAIRRSLKGTTVGAGNLPSNLLNLITSQLAEQVEQVKIWPQMLSTEEISRLWTAFQAKYRPTAAYQASVVLIESTVSTKSSLPVLTRGLYAFPSQRPVVTSVLSQRPVPDAKPADQPILFNYTLLLQGSSLQGESTTVSFTTQDAAPTSTTASMITVPLPAGLLAGAQVLTVNQTLLAGSPPTSILTQQSEPLSFVLRPTLVSATVEGLTGAGDSPRNGTLHVVIAPAVDPAQRLILLLNLMETMPTTGAGYSFPGPAPVSTDPSGALSAPTDTFDIPFAGTVPGTYQVRVNVGGVDSIQIAPDGSVQSMQVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5I7</accession>
    <name>E8X5I7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3611</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70614">
        <property type="protein sequence ID" value="ADW70614"/>
        <property type="gene ID" value="AciX9_3611"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3611"/>
    <dbReference type="HOGENOM" id="CLU_2861461_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="64" mass="7064" checksum="311D5127F7B42894" modified="2011-04-05" version="1">MTAVCPACAETKLKPVHSTLPDTLLELMGIHHYRCPFCRRNTYTAAPLAHISQPEKPSASLHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5M3</accession>
    <name>E8X5M3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3647</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581961.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3647"/>
    <dbReference type="EnsemblBacteria" id="ADW70650">
        <property type="protein sequence ID" value="ADW70650"/>
        <property type="gene ID" value="AciX9_3647"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3647"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371635_0_0_0"/>
    <dbReference type="OMA" id="FEIATEH"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230255" evidence="3">
        <location>
            <begin position="18"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="4">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="748" mass="82075" checksum="02B08053F2C917E6" modified="2011-04-05" version="1">MRSLCTILLLTVSLAHAQNPPQTLTATSEDTITLALTPTPLPLHDFTFNGDPVPTSKLHLKQLSPGIFEITSTAYAVGDWHFAVADAPIGVYGLGERFDVLNHSHTIVRNTSQDNGGPKGSTTYKPMPFFMSTTGYGLWLDTTGEATFDLNASSRDDIEVDAVASHLRIVLFTGQKTESQPTGRFPYILGDFASLAGKVTLPPYWAFAPWQARDYHQNQAQVLEDIDKTRALGLPASVILIDSPWTTSYNSYVFNPKQFDDAPAMIKHLHDQAFKLVLWHTSWIDNKSNPPGEKGFTDKLSEKSPNYDEAAQKGFFIHNPDGTSYVGTWWKGKGSLIDFTNPAAKSWWQDQVRQAIRAGADGFKDDDAEGNFQGPTADLKFFDGTDPRLMRNRYDVLYNNAMEELIQKDLKGNGVLFARSVSAGANGIGLLWGGDNEASFSKDNGLPSVVTAGLGAGLSAMPLWASDTGGYLGLPDTPNPLLLQRWTEYSAFSPAMEVMSTRNIVPWTFDTNSPAGTTPALDTYKKFVILHMSLFPYRYAAAQQAATAGQPIMRALVLNYQDDAKARAIHDEYLFGPDLLVAPVIDENTSRPVYIPQGDWLNLFTGDPVTGPRTLIAQAPADTIPVYARKGTILPKIPEDIMTLVPAEESGNKDIHTLDNRRVYELLGPAASTPTTITDFEARTLTRTGDTLTITGDKPAHIILRLRFQTSIPKTATVNGNDTPINPDANNIPTIEFDHTSTTNITWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5R8</accession>
    <name>E8X5R8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion protein, VC_A0114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4006</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572714.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70802">
        <property type="protein sequence ID" value="ADW70802"/>
        <property type="gene ID" value="AciX9_4006"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4006"/>
    <dbReference type="HOGENOM" id="CLU_031690_3_1_0"/>
    <dbReference type="OMA" id="YTYFELD"/>
    <dbReference type="OrthoDB" id="496911at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="451" mass="50696" checksum="7A18C6BF14A01CDB" modified="2011-04-05" version="1">MRQLQPVIWSKGTFLSPQHLQSQERFVEDTVRFYLDSLVSKSWGFLKIQIDAKALTEGTLTISVATGIFPDALPIDVPASDPAPPSRVLDECFRDGRETCMFYLAIPQYLQGGMNVSLQRGRVSTRYLAQLQMTRDENSGSNEKPVQVARKNLQLLAEGENLEGSVLLACARVLKTETGMYHLDPTYVPSLIDVHGNETLTSIIRGLIELLVTRSSQLSGSRRQKNQTLADFTASDVANFWLLYTINTHLPGLRHYLESSSVQPEMLFGDLSDLAGALTAFSTQIDPRDLPRYDHDNLGPCFIELDRLLRIMLETVVPTNVVSIPLNLTRETIYAASIDKDAWFDNSRFYLAVSADMRDTDLIDRIPKLTKVCSATHIEMLVRQALPGIKLTHVEQPPRAIPVKLRYQYFSIERSGTAWEAVQRARNFAVYAPSDLLNPQMELIILLPKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U2</accession>
    <name>E8X5U2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572738.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70826">
        <property type="protein sequence ID" value="ADW70826"/>
        <property type="gene ID" value="AciX9_4030"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4030"/>
    <dbReference type="HOGENOM" id="CLU_009318_3_0_0"/>
    <dbReference type="OMA" id="GAEQSHM"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234221" evidence="1">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="336" mass="35475" checksum="6F75B9B99DD35525" modified="2011-04-05" version="1">MKIASSSRLLTLIACLAMMQPLWAQAHTEASAHGTLLVVNQADHNVSFLPASSGAASAVDVGGITGHELALTPDGRTAFIPIYGNSGVGKPGTDGQTMTVVSVPSHKVIGSVDFGHPVRPHCAIFDKKRNLLYVTTELDKAITVIDPKSLKIVGTIPTGQEQSHMLTISHDGRFGYTANVGPGTVSVLDLNTRKTVKIIPISAQTQRISISADDRKVFTADQTKPQLAVIDTATNTLQSWIPLPEIAYGTAPTPDGHWLLAALRPTNQVAVIDLKTMKVTTTIDVPKTPTEILIRPDGKAAYVSCGGKVAVIDLATWKVQSILQAGAGADGLAWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5V8</accession>
    <name>E8X5V8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4048</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572754.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70842">
        <property type="protein sequence ID" value="ADW70842"/>
        <property type="gene ID" value="AciX9_4048"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4048"/>
    <dbReference type="HOGENOM" id="CLU_036287_0_0_0"/>
    <dbReference type="OMA" id="RWISTAT"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="421" mass="46379" checksum="4717950B1DD7D0D1" modified="2011-04-05" version="1">MQTEIQGIPSEVVEQQLGRLRSSPLFSHSRRYPTFLDYVVRKMLNGQGDELKERTVGIEAFGRASDYDLNADPVVRVTAGEVRKRLAQYYYDPEHLHELRIELRPGSYVPEFRLAESPAVGAPPSRALTLSDNNITKEPGVLPYPALPSTPPLVPVQPAWHDAHINRWRGLSICLAVALAVAIVAALMPHLRRDSATDLFWRPVIDANGPVMISVGSVVAMVNSNAVAPAPFTVSGHPLASDPIAVSDATALSSIQQVLSMRSKTSTLASSTGTSFSDLQKGPIVLICGFNNQWTMRITDPLRFHFVRTSTDDYTIQDRDSPEHRQWSINTAGAFIKMNDDYGLVARFHDPTTEQVVVVAAGIGENGTIAASQVLTDDRYLAELRRNKLLPRPDQNFEAIVQTQIIDGKPGPPRIVASYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5X0</accession>
    <name>E8X5X0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572766.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70854">
        <property type="protein sequence ID" value="ADW70854"/>
        <property type="gene ID" value="AciX9_4070"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4070"/>
    <dbReference type="HOGENOM" id="CLU_521686_0_0_0"/>
    <dbReference type="OMA" id="DATHHWF"/>
    <dbReference type="OrthoDB" id="1726711at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="524" mass="59314" checksum="FED2D5DFA1406819" modified="2011-04-05" version="1">MSTPTSANSKYGVSRRDASKAQRWLDVLLLFAIPGYLFINLFTLHGVPHLIVSDDGLFVLDSLRMGEGLRIYRDFFQFNAPGIDYIFRIAFGLFGIHTWVPALVNLVLGTSLSYVALYLCRRLMPRRWAILTTALFVVFIYGRWLDATHHWFSLLAILLAIVILIPGRSPLRAVIAGGLIGIAAFFTQTAGTAAWLAFSISLFYERVPLPSARAMLRRQASLLVSGILVWFLLSASTLMHVGWRTVWYFQVVFPRGYELRVDTNPLLTLGHVFPRSLSFVQWENVLFYLILVCTTPIAVYLLWTSRLRNKSCSADQQMAAALLASSGLLLMAEVVARATWIRLYADFLPSMILFFAAIAYLLQRRPALSRLVLLALWSVTIISGIRQTRFNHATHIDIASLPTGWIALSPQDGEEFRTLAKLTHPGDLFFQAFGVDLYLPLGVRSPVYMDYLRQSSVTRPEFLANAISALRNNHVHYVILRPVSEITFDPTQGHVLDPLYTWIETHYMLAQHFSNGDQLWELQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X0</accession>
    <name>E8X6X0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-dextrin endo-1,6-alpha-glucosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pullulan 6-glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_3793</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.</text>
            <dbReference type="EC" id="3.2.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582101.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71079">
        <property type="protein sequence ID" value="ADW71079"/>
        <property type="gene ID" value="AciX9_3793"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3793"/>
    <dbReference type="HOGENOM" id="CLU_004744_5_0_0"/>
    <dbReference type="OMA" id="DKIVPWY"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011839">
        <property type="entry name" value="Pullul_strch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040671">
        <property type="entry name" value="Pullulanase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17967">
        <property type="entry name" value="Pullulanase_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02103">
        <property type="entry name" value="pullul_strch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="576"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125152" checksum="3498799FF154DA28" modified="2011-04-05" version="1">MQRKFCLGVFRLFVFLLCGLGVVLQAQTPIPANHIRIHYHRADAVYTGWTVYGFGQTTEDTSNFESGPVQVTGTDSFGAFFDVGVVAGASGAQSVGIIVHMGDTKDTPQNEYADPSQGSNFYQLSGATSLTTTQPPIPVNHKNPNIPANTARIHFYRPDGIYTNWTVYAFNDTTEDESNYNSGPIFPTGTDAYGAYYDVPLIPNPNDLGFIVHNIATGTKNTPADLHLDVADYNEAWIISGDPTVYLTQPTAAQLLNANFLKLQAFWIDKKTILIQNAYAAPGGSYYLSSDKSAALALGANGVTGGTKVTLKASGSLTAQQIARFPQLATGYTVLTLPANISAAAYLNLVQGQLAVTVLKSDGTSSYATGVQNAGVLDDLYAYTGQLGVIVRHSGFDDCWSDFADDEDGRVKVKVWAPTAQTMKLQLFKASTDTAPAQVVTMHEHDGVWVAKLDESWIGKYYLLDEMVYAPSTRQVVENIVSDPYSIDIALNGTKSRLTDVDADSNKPYGWDFDRSPYLDRLNDLTIYELHLRDFSIGDKTVPTAHRGMYLAFTDRNSDGMEHLRTLAQSGLKAVHLLPTFHFNSVNEDKSTWATTPDLTSFAPDSQSQQAAVTAIQSADAYNWGYDPDHYLAPEGSYAVNPDQRVREYREMVMSLHHAGLRVIQDVVFNHTSGFGEATNSILDEVVPDYYNRLDADGNLETGSCCADTATEHLMMGKLQQDAILWNAKKYKIDGFRFDIMSFTFVKNLEEIKKALAKLTPERDGIDGSKIYIYGEGFSFGETANSALGVNAQQSNLFGTGIGSFNDRMRDGVRGGGPFDDERVQGFATGLLTDPSLYTTSIAGTSAADQQSTLLHRTDWIKVGLTGNLRDYTFVDATGKTITGAQLDYQGQPTGYTATPIEAVNYVSVHDNQDLFDTIQVKASLNDSSAIRAKRQVLAMSLVALGQGVPFFHAGDDLLRSRDMDQNAYDSGDWFNKIDWTGTGNNWGIGLPIASQNSSQWSFQQPLLANGAYKPQPADIQSTTRAFQTFLRIRESSPLFSMSNAAEIQQHLTFLNAGPSQVPGLIVMNLQANARNYGPYGQIVVVFNASDQEQSFTAAQLKGLTLKLDPLQAEADPTLKETARFDRQKGTLTVPSLTTVVFVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X5</accession>
    <name>E8X6X5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3798</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71084">
        <property type="protein sequence ID" value="ADW71084"/>
        <property type="gene ID" value="AciX9_3798"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3798"/>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_0"/>
    <dbReference type="OMA" id="TREYEGI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="254"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="443" mass="46836" checksum="7F6D175256C2F604" modified="2011-04-05" version="1">MRGVRYHNQTMSTSPNPAVTGLPEPMSMGEVLRVPIMRRLWIAQLVSTFGDFLALFAVIGVLTFKLKDTAQQVTGLQIAYLLPIAVLGILAGVFVDRWPLKPTLVVSDLTRSALCLLLLLATKTFHFYAILACISILSSFFSPAQGVAIRSAVPMHGLRSANALMQQVLFGMRIVGPGLATILFTTFGPRICYMADAASFLASGCLIASLTLKRVTPEDKQSLETPLDTPAAAPSAKPGLSNILPDMRQGISFIVHHAAVLFVIVALAAGMFVLGCFGPLIAVYVRDSLHASTKIYGTASTMIGIGMFLGVNLLNTVGKKIKNSTLVYGGLGGIAIGLCFLAFLLHIWATVIGTLIIGIAVAGIVVPSNTLIQQETPAALMGRVGSTVMSLVFSAQIAGLILSGLLANRIGVRHVFAVCGLLLVVLIIAGKLFMEPKPVPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Y1</accession>
    <name>E8X6Y1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3804</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582112.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71090">
        <property type="protein sequence ID" value="ADW71090"/>
        <property type="gene ID" value="AciX9_3804"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3804"/>
    <dbReference type="HOGENOM" id="CLU_1737990_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233756" evidence="1">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="150" mass="15718" checksum="7C7FA200197844E1" modified="2011-04-05" version="1">MQPTQPITRRTFLHSVAALSAVSITPALAASPILALNPTPACSTLSADRRHLYLAHAADPSASLPAGTVESYSIHPRTGALTLLNRQSLALFATTPTAITIADLNLRVQLGPHAHNLLPLNPDGSIARLTHSIKRITLVPSATAPVNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6Z7</accession>
    <name>E8X6Z7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3820</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582128.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71106">
        <property type="protein sequence ID" value="ADW71106"/>
        <property type="gene ID" value="AciX9_3820"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3820"/>
    <dbReference type="HOGENOM" id="CLU_013093_1_2_0"/>
    <dbReference type="OMA" id="PLSGYNW"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230829" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="444"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="524" mass="56455" checksum="F95A488D25A01021" modified="2011-04-05" version="1">MMLTKTLTNKTCLLSGLLLSTALIAQAQTGLNGYWDLRLPNTDGSFRHTYLELNASGETVSGKLFGRNVGGQAIEGTLKAGKIRFATVPPPLKPGSPASIGSTVTPIVYDGTFADGKLTLEFHRYNGGSVTGEAIRTTREAAVPPAPLPLPAPKDIPDNGLVRTPPMGWNSWNKFAGKITADDVKSMADAMVATGMNKAGYQYINIDDTWEADRAADGTIQTNNKFPDMKGLADYVHSKGLKIGIYSSPGGKTCAGYEGSFGHEAQDAKTFAAWGIDYLKYDLCGARAIYESTLENERGLYQKMGEALSQSSHPIVYSLCQYGDADVWKWGSKVGGNLWRTTGDIRDTWESMDKIGFSQIAISSYTRAGHWNDPDMLEIGNGGMTPDEYRTHMSLWSMLAAPLIAGNDLRSMSPETSSILLNKEVIAIDQDKAAKPVQALSTKGKVETIWRPMEDGSIIVGIYNRGDAATPANLPWSSLPAGYATKHVSVRDLWKHEAVPANGPAYTASIPPHGVALLRIGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X753</accession>
    <name>E8X753_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4334</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71287">
        <property type="protein sequence ID" value="ADW71287"/>
        <property type="gene ID" value="AciX9_4334"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4334"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_0"/>
    <dbReference type="OMA" id="HWIFWIS"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="519" mass="55195" checksum="375D00875A93F4CB" modified="2011-04-05" version="1">MPESSGKGSGTNPWLIAVAVMIATFMEVMDTSIASVAVPYIAGSTASTTDEAEWVLTVYLVANAVFLPASNYFAQRFGRKRFLMFSLALFTLASFLCGIAPTLPFILLARIIQGAGGGALQPLSQAILLESFPPAKQGQALGVYALGVVLAPVIGPAFGGYLTDTLSWRWAFYINIPVGILALVLQSKFLPDSKPEGKKAGAFDGIGFGLLGLWIGCLQFILDKGQEDDWFADARIRWAAGILIVTFVLFLIREFRHKKPLVDLRAFSDRNLAIGCALVFALGAVLYGLTTILPVFYQTLLGYSATASGFAVSPRGLGSVAASLIVGALVSKFDARWMVAAGFAVLGVSGLWLADLTLDISPSTEFWPIAVSGIGLAMIFVPLSKVALATVGKKGTGNASGIFNFLRNVGGSIGISAANTIAQRHLQSHRNDLVRTYTGASWILRRQLTLLSQRLSAHAGLAGHTATLRGFSITSTTLNAQAQLYAYVDVLRYFGFICLICVPFAFLLSKPAKDAQGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7L7</accession>
    <name>E8X7L7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HipA N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_4509</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
            <plasmid evidence="7">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HipA Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4509"/>
    <dbReference type="EnsemblBacteria" id="ADW71451">
        <property type="protein sequence ID" value="ADW71451"/>
        <property type="gene ID" value="AciX9_4509"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4509"/>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030167_3_0_0"/>
    <dbReference type="OMA" id="FCQAMGL"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03071">
        <property type="entry name" value="couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Couple_hipA" evidence="5">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HipA_C" evidence="4">
        <location>
            <begin position="145"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW71451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="414" mass="46299" checksum="D3354BE0048A7F73" modified="2011-04-05" version="1">MSKRRNLAQLSVWLNQTLVGSLTELPNDRNLFVFDQGYAENPQRPVLSLSFTAAEGQLITEPVTTQMRVPPFFSNLLPEDELRRYVAERVGMKGVRDFPLLQLLGEDLPGAVTVRPESEGPPSEEIEPQGPANPITAQDDSPLRFSLAGVQMKFSATGSPERGLTIPVEGKGGHWILKLPSIRYPLVPENEYSMMQFAQAVGIGTAETGLVPVEEIEGLPEVFRKQIANALWVKRFDRMSQNKRVHMEDFNQLYGQFPEEKYKNYSYGNMATDLVRAVGLPAAEEFMRRLIFSAAIGNADMHLKNWTLLYADGTTPELSPAYDLLSTIAYIPDFTMSLSMAKEKDVRKLNKELLDRFVAKIPAPATPLIAAALETAERIMLVWPSIRDGLPMTDDAKNKVTERMHIFPLTKGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W3</accession>
    <name>E8X7W3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4617</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71547">
        <property type="protein sequence ID" value="ADW71547"/>
        <property type="gene ID" value="AciX9_4617"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4617"/>
    <dbReference type="HOGENOM" id="CLU_1537948_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230326" evidence="1">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="174" mass="18745" checksum="5E8138B51A161E65" modified="2011-04-05" version="1">MGLDSCWLCVLNFSILAAIPALAQGSPVAPPPAQVTFYSHGVTMLGGLPGHDPAAFKGRIFDADHQLAFMEPSHFITFNMAPGLHTLSATWWTAKHSNSGAHITLNLVGGEQYFIETMVLNSGFMFGSVSLKIREVTCEGARRDNTHSKPLEATHLRPDGVPIALLSTTFPQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W6</accession>
    <name>E8X7W6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4620</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573269.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71550">
        <property type="protein sequence ID" value="ADW71550"/>
        <property type="gene ID" value="AciX9_4620"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4620"/>
    <dbReference type="HOGENOM" id="CLU_859870_0_0_0"/>
    <dbReference type="OrthoDB" id="2100150at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="323" mass="36187" checksum="850C1C0E13E27A18" modified="2011-04-05" version="1">MPKYIYPDMPEMGTEEDYETQSYWPLCYPRIYDNVSAYTSPKAVAFDLASIFRSYALFFRRSPHQLDRDTHNAGMIAAASFHAARLTDLRVPTFFVEHDLLMALSKTTPPEAIDWKALHLPFDAAVFILPPGAITIPGSGSIGFLWYSRAFEGNRVRVPSGVEHDFTLPKSQLYIRTVLAEKPGSPAVVHHIIDGEANTLIDLSKALEDNDVMPGSVPFSVAERRLGGMIAGLVFNLVLAMAARPELLTQGTFSGKRSKRGSEFWQPNIIGKNYRVSGSDGKGVTGLTHRMHWRRGHWRNQGYGVQRMQHRQVWIEPTLVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7W9</accession>
    <name>E8X7W9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative relaxase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71553">
        <property type="protein sequence ID" value="ADW71553"/>
        <property type="gene ID" value="AciX9_4623"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4623"/>
    <dbReference type="HOGENOM" id="CLU_001748_0_2_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014059">
        <property type="entry name" value="Conjug_relaxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02686">
        <property type="entry name" value="relax_trwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1206" mass="132860" checksum="3F2B733CDF836DBF" modified="2011-04-05" version="1">MLTLSSALNAGQAATYHKLDYASSTQSYYQQGEEVRGEWRGELAASLGLSGEVSSLAFNRLAEGQHPETGEQLVRHREAQEYKNLDGSTTKAVEHRAGWDAQFAPSKSVSLTALVGGDERVREAHREAVGVALAELERFTQARIGGNNPAETTGKFVAATFEHDTARPVDGYAAPQLHTHAVIFNVTERADGSTRALQEKAFFESQNYVTAVYQAELFQRLKNLGYEMEAGKSGAPEIKGYSAEYLEASSPRSAQIREHMEKAGFTGPGAAQIAAHATREAKQELTSAQVLAAHRDLAATFGNQHETVINAARSRTRENAVTPEQSNQAREAVTYAKAHAFEREAVADERVILRDALRRGMGDVTAAEVRAEFQTRQRAGEFRSVEAPKYASAGRFTTPETIAQERANINHVLQGKNTVSSITTAAMAEEQANARGFLNDSQRRVVEDILTTRDRVHGLQGLAGTGKTTALETIREGAEKSGYRVEGFAPTSKASGQLRDAGIEANTLQSFLQRKTAMDPDARHLYLLDESSLASSKQMRQFLDKVGPNDHIVVIGDIRQHQGVEAGRPFQQMQDAGMRTSQLDQIVRQKDPELLRAVEHLARNETERGIALLREQGRVTEIPNGPERIQAIARDYASKPESTIIVSPDNKSRQLLNEAVRVELKEKGVLSGNAETFRTLTNRNDMTGAERTWAARYELGNILQYTTGSKAEGIVKDSFAIVRSIDTAANRLTVELENGKIVSYDPKRLRGVNAYRESTREFAAGDRIQFTTNAKTLDIRNRDLATVVSAAPGQMTVRMDGKGERTVTFDPAKLRQFDHGYAVTSHSSQGLTQDRVLANFDTGTARSLVNTRLAYVAVSRASQDARIYTNDADSLGKRLSVDISKTAAIEIPRAEVKSELRKAVEGFRAGKTDVSIDKLKSQGKVHQHAQPSERISAVAKEYAATRDRTVVLSEKQSDRAAITAQVRAELQQAGRLAPNKEVRTVLQEQHFRQEGRAADYKPGDVIQYGKGSPKHGLLPKTEATVEAVDSRRNLIIVRTGQDDLVTYSPSRLKTATNDSKVYRPEQQPISQGERIRITRNDKELNVRAGDFATVTRIDDRGSLKVRLDSGKEIELMPRQARHIEHGYAVESGRRISAERFIVTGDTPEARSLKSIPANARDVSIHTTAPAVQQQKAPEREKTPQQEQGQKPPQREIQRGYGIGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z2</accession>
    <name>E8X7Z2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4646</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573295.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71576">
        <property type="protein sequence ID" value="ADW71576"/>
        <property type="gene ID" value="AciX9_4646"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4646"/>
    <dbReference type="HOGENOM" id="CLU_2665963_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8169" checksum="44C40C80ACD5C4B6" modified="2011-04-05" version="1">MTLNLSFEDLKRIALDGRVVKNGITLIVGRPLIPDVKTDTSGKLGEVRFTVDDRQVQPHGRRLVKPAAGTSQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7Z4</accession>
    <name>E8X7Z4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_4648</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71578">
        <property type="protein sequence ID" value="ADW71578"/>
        <property type="gene ID" value="AciX9_4648"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4648"/>
    <dbReference type="HOGENOM" id="CLU_024675_0_0_0"/>
    <dbReference type="OMA" id="ETCYLAF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="359"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="414"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="487"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="668" mass="74561" checksum="A4801616D7289FEB" modified="2011-04-05" version="1">MEWRFCLTRRKRLDLSSALARGEFVPYFQPLVDLRTGELRGCEVLARWVHPTRGIVLPDDFIPYAEESGIIAALSECVLSKAFEACATLNQTFVLSVNISPIQFRDPILSKRLSELSTRHRFPLDRVKVEITESTLLTNLADAQSISTQLKLLGVKLSLDDFGTGYSSLAHLQALPFDEIKIDRSFVSSMCCRRESMKIVAAVIGLGRSLGLTTVAEGIEESAQADMLRCLGCEVGQGWFYGRPVPIEELQAMLALSRPSSHRVGHTKQVPKQRITSFLEALPAARHAQLQAIYDGSPVGLCFVDRELRYVSVNQRHAQMNGAPAEAHLGRTVREMVPEPFYEKVVPYLTRALGGEAIHGVELERRDHIKGVKCATILSTYQPAQDENGEVIGVSVTVVDISDRKAAERALAESEDHFRHMVQLNPQIPYTMDPNGLILDMSPRWAELTGLTFEETCGRGWLRTVHPEDATTLVSKCLAAIKAAVQIDVEFRVLGRDKLWHWMRSRAAPRMDRDGAIIKWYGSVELIDDQKQAQEQLWASQLRLQTIIDTLPVGVVIAEAPSGRIIGRNQKAEAILQQDPLHFEQIGDYSRRVAYHRDGRRLESDDFPLAKAILRGQITDAEHVYYTFGDDVGKWLSLSGAPLKDRDGKIVGAVATIQELNGETSHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8X849</accession>
    <name>E8X849_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4706</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71633">
        <property type="protein sequence ID" value="ADW71633"/>
        <property type="gene ID" value="AciX9_4706"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4706"/>
    <dbReference type="HOGENOM" id="CLU_1427367_0_0_0"/>
    <dbReference type="OMA" id="HECIWSE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="231" mass="25034" checksum="18F087C000746F28" modified="2011-04-05" version="1">MRCAGALLIRKPRRCQKRLSGRCRIESQPSENRALVNSIVRTAMKTFALCLLACLMLAPMRIWSQSEQALPPEIRLELLPTAFADGVASGFIFVLTNVSGRDISIPPPEFNCSSPSQNGFIRFQWAFVPVNGDGIGSGISSCGPGGGIYPVPPLTVSSLTRNWTLLHPGESLRVPANWPPSSGLMLSGSYTFSASYSPPKISSEAEHLLSEAGIIIPRQKVETPEQHYGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV62</accession>
    <name>E8WV62_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">AciX9_0163</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578565.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0163"/>
    <dbReference type="EnsemblBacteria" id="ADW67237">
        <property type="protein sequence ID" value="ADW67237"/>
        <property type="gene ID" value="AciX9_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0163"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_0"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="408" mass="43136" checksum="E0D4EB192F2ED7B8" modified="2011-04-05" version="1">MKILLGVSGGIAAYKAAELVRTLQQAGVDVQVAMTASAERFITPLTFAALTGHPVLTSLWQPTDAPSESFEIEHISAVQHIDAFVIAPATANLMAKFAHGLADDFLTTAYLANTAPVLLAPAMNVNMWNHPATRANLRTLKERGTTIVEPVAGYLACGMTGSGRLASVETIATEVLNLLHPRHDLAGETILITAGGTREPLDPVRFLGNRSSGKMGHALAESAAARGAKVILVTASPLPAPQSATLIRVDTAHEMQSAVLAQLPQATIVIAAAAVADFRLREVALNKLRRNGPLTIELEPTEDIVAHVVANRRPGTLVIAFAAETESLEENARAKLQRKGADAIVANDVSLPGLGFDSDSNAGLFLTGTQTISLEPASKQVFAGRILDHAIALRAQTVFRTEKELSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WV74</accession>
    <name>E8WV74_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0175"/>
    <dbReference type="EnsemblBacteria" id="ADW67249">
        <property type="protein sequence ID" value="ADW67249"/>
        <property type="gene ID" value="AciX9_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0175"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="DEHRWQA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234072" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1156" mass="122288" checksum="6A99D51DA3690DB7" modified="2011-04-05" version="1">MVSRRLLSLAAVSLVCTGPMALSAFAQSAALGGIAGIVRDSSGAVVSGASVQIKNTQTGAARTVTTNSEGHYEATFLQPGMYEVILGGGSFATVDQKNVAVTVGDTRTVDATLGLSSVSTDVIVTSEAPLIDTEKVEGSQVVGQQLISNLPIASRRFESFVLLTPNVVPDGNTGLIGYRGISGVYNQNLIDGANNNQQFFSEARGRSIGSPYVFPVDAISEFQSSATGYSAELGGAAGGIINAITKSGTNQFHGDAYEYYRTPGFNALDPYNKYNGRLQNNPYLLSQPVKVQHQFGISAGGPIIQDKLFFHFTYDGYRKVNPVSYLSTYNSTTTSVANLAHLCDGGTVHVQDGTTIYPTTIPNVSATQCAAGVTAVQSQLGSFGRSAKQDIYFPRLDYQLNSKTHLSAEFLFANFHQPNGYNSSVTVSNGGVSQNGTADFHERILIANAETQVSSRSTNVVHFQWARDLETDGTNSGGPSNSLTNLVALGETSALPRGKFPDEHRWQATDVYSTTLGHHTIKAGFDLNFVHEQIANLFGGDGSFSYSNSNAEYNFTNFLQDALAVNPTLTTAGGTPVSRHYNSFSQTVDQLTGVGADDFWNQNIDGFVEDAWKATPKLLVSVGVRYDVQLVPGPDLPNTANPVAFNATSQINPDLKMIQPRIGFAWNPYPGTVVRGGYGIFYGQISNSSYYTLRRENGVYQKQYGPITPAVTPVPYVVTGGAVTGSGTTPGTCAPTAGSNVCYTNPGSFVSYAPQGGVPIFTPPGPAPTNPVTGGAITSTGLAAVPSGTITIRGLDPSFQNPQSHSADLAVEQQLPLHSTLTVSYVGNRALRLPVYVDTNVDPNSVITTRTYQYTNAQGVTSNFAEPIYRNRLYTNTGAVATGFSDVNSWYHSFVASVRKPMSHGVEILANYTWAKALDGGQTYGGNGTFNGTDAPLIPFALGAHKGRSNEYSRSDLDIRGRFVGTIVAKSALPIANHYVAYAANGWLLSGTLTAQTGEPITATVNGSITYLTSSSTALGNLTSDAGVTNAVFTSGPGARVPDYIASRNSFKGPGVHNVDARVSRDFPLKSDRYHFEVAAELFNVLNHRNILSTNTALVAYSAPGASGCPTVASNPNGVGCLGPLSASTAAFASPASTSNIIYGARQMQLVGKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVF3</accession>
    <name>E8WVF3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1341</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579724.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1341"/>
    <dbReference type="EnsemblBacteria" id="ADW68401">
        <property type="protein sequence ID" value="ADW68401"/>
        <property type="gene ID" value="AciX9_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1341"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_0"/>
    <dbReference type="OMA" id="MPHGMLD"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="394" mass="44098" checksum="06DD115AC3061626" modified="2011-04-05" version="1">MSEAPTTKRILHVIETLDPAAGGPTESVRALITFGPANYIGEAVTLDEPDAPFLKTYPFPVHALGKGKTSLGYSRKLDQWLAANRDRFDGVVVNGLWRYISFAAWRAVRGRKPYVVFPHGMLDPYFKRRYPLKHLKKWVYWLLSEYWVLKGAYRVLFTTTEESQLAEESFWLHDWNGFIVPLGASRPPADGALLKDAFYTQFPELRGKRFVLFLGRIHRKKGCDMLIESFVRLAATDPELHLVMAGPDQQGWSAELQATVAAAGLSDRVHWPGMLKGEVKWGSLFASEVFILPSHQENFGIAVAEAMACGRAVLLADKVNIAPEIAADGAGLMETDTQAGTDRLLERWIAMSLPERAEMERKALDCFSRRYDMHTNAVTIITLFDDAAAPASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVI0</accession>
    <name>E8WVI0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase IS204/IS1001/IS1096/IS1165 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0999</name>
        <name evidence="7" type="ordered locus">AciX9_1368</name>
        <name evidence="9" type="ordered locus">AciX9_3850</name>
        <name evidence="8" type="ordered locus">AciX9_4049</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 10">
        <name>pACIX901</name>
    </geneLocation>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">pACIX901</plasmid>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Granulicella sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68065">
        <property type="protein sequence ID" value="ADW68065"/>
        <property type="gene ID" value="AciX9_0999"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68428">
        <property type="protein sequence ID" value="ADW68428"/>
        <property type="gene ID" value="AciX9_1368"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70843">
        <property type="protein sequence ID" value="ADW70843"/>
        <property type="gene ID" value="AciX9_4049"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71136">
        <property type="protein sequence ID" value="ADW71136"/>
        <property type="gene ID" value="AciX9_3850"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0999"/>
    <dbReference type="KEGG" id="acm:AciX9_1368"/>
    <dbReference type="KEGG" id="acm:AciX9_3850"/>
    <dbReference type="KEGG" id="acm:AciX9_4049"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_0"/>
    <dbReference type="OMA" id="CERQTFT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="5">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW68428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW70843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW71136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="527" mass="59843" checksum="38F35F09BD20152C" modified="2011-04-05" version="1">MVRGTLLPSTSEVELVCLRPRTGLIEVELRTSRPFSCCPVCGTASRRVHSRYLRRLGDLPWEGIPVSILLQTRKFFCVVETCRRRIFTEPLSGTVLRYSRRTLRSCEALDWITVMIGGQAGARLARRLGLLVSGSTLLRQLRCRARCAPVVAPRVLGIDDWAWRKGHRYGTILCDLESRRVIDLLPDREAGTVAEWLREHPGSEIVSRDRGGIYAQATRLAAPGAVQVADRWHLLRNLSEALKNALSPHHRLLTQAARSSMGEVPGVVTSPQPSVPPWELRASLRNRERRFSRYEEVHRLGQTGASHAAIGRQLGLDHRTVRKFLRTETFPEAQRSPRPGIVDPYAEYLDRRLEQGCRNVSRLWRELRERGFTGQLNIVRRWLRCRRGYQPTSAAAAPHRAAPRISVRQTVWHILKETPSAQTYLEQVYQASPEVSVAAKLAKEFFRLITQRDLPALTPWFEAAKTTALAGFASHLTRDRDAVEAALKLPWSQGQVEGHVHRLKLIKRQMYGRAGFDLLRLRVLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVJ3</accession>
    <name>E8WVJ3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1382</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579763.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1382"/>
    <dbReference type="EnsemblBacteria" id="ADW68441">
        <property type="protein sequence ID" value="ADW68441"/>
        <property type="gene ID" value="AciX9_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1382"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_2_1_0"/>
    <dbReference type="OMA" id="NNWAVTI"/>
    <dbReference type="OrthoDB" id="1551899at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW68441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="135" mass="13842" checksum="25ACB6F9F89C3673" modified="2011-04-05" version="1">MSHTVTLAEARTVIAAATAEAEKIGQPMNIAVVCAGGYLLAFERMENAWLGSVDIAQKKAWTSRAFDIETGTLGTLSQSGDQFFGINASNDGKVMIFAGGVPLLRDGKVIGAIGVSGGLGAQDQAVAEAGAKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVN7</accession>
    <name>E8WVN7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase, F1 complex, delta/epsilon subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2536</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580881.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2536"/>
    <dbReference type="EnsemblBacteria" id="ADW69566">
        <property type="protein sequence ID" value="ADW69566"/>
        <property type="gene ID" value="AciX9_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2536"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149174_0_0_0"/>
    <dbReference type="OMA" id="LPHRLDC"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024037">
        <property type="entry name" value="Alt_ATP_synth_F1_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03166">
        <property type="entry name" value="alt_F1F0_F1_eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0139">CF(1)</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="130" mass="14386" checksum="E641CE1D3080BFEF" modified="2011-04-05" version="1">MQLKVLLPSGIFFESDNVERIVAETRSGSFGILPHRRDCVAALAPGILTYQEANGSPAYLAVDEGALAKVGMKVLISVRRAIRGTDLGQLHDEVKRQFLTLNNEERQVRDALHKLESTFAGKLAEFAHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVX4</accession>
    <name>E8WVX4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3732</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582042.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3732"/>
    <dbReference type="EnsemblBacteria" id="ADW70733">
        <property type="protein sequence ID" value="ADW70733"/>
        <property type="gene ID" value="AciX9_3732"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3732"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134960_0_1_0"/>
    <dbReference type="OMA" id="YQNALYF"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="144" mass="16095" checksum="A7DB56EF0BF9CF2A" modified="2011-04-05" version="1">MTLSPEHNGRFQGASADITERIIGIFYDVFNELGYGFLESVYKEAMRVALLDAGLSAQAEANIPVYFRGAVVGIFKADLIVEQQVILELKTAEVISKAHEGQLTHHLMSSNIEVGLILNFGESPKFRRILLTNDRKKNTKKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWE0</accession>
    <name>E8WWE0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2578</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580919.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2578"/>
    <dbReference type="EnsemblBacteria" id="ADW69604">
        <property type="protein sequence ID" value="ADW69604"/>
        <property type="gene ID" value="AciX9_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2578"/>
    <dbReference type="HOGENOM" id="CLU_2734376_0_0_0"/>
    <dbReference type="OrthoDB" id="1965070at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007039">
        <property type="entry name" value="TrbC/VirB2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04956">
        <property type="entry name" value="TrbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233434" evidence="2">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="71" mass="7523" checksum="C5925B208DFEEBAA" modified="2011-04-05" version="1">MKTLHRAARVERPNLRPSFSGFLLLTLLLFPLAAHAQTGSSPFDTGLTSIQTLFTGTIAKVSSLIAIVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWF3</accession>
    <name>E8WWF3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580932.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2592"/>
    <dbReference type="EnsemblBacteria" id="ADW69617">
        <property type="protein sequence ID" value="ADW69617"/>
        <property type="gene ID" value="AciX9_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2592"/>
    <dbReference type="eggNOG" id="ENOG502ZCIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473909_0_0_0"/>
    <dbReference type="OMA" id="WRNPRAR"/>
    <dbReference type="OrthoDB" id="1492246at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="565" mass="60505" checksum="EF722D3A35506E8B" modified="2011-04-05" version="1">MAGLTERLPPVPASAQFKAVAYLRWRLFANTFRRKEGIGELAAKIIIYPISLLFLAGPVAGATFGSYYAISESHVELMAVVFWVIFLLQVVVSINIAPPGLSFDPESLIRFPLSFPRYLVIRLFLGLLSASTIAGTCALLGAAVGVSVARPELGVIAFAAAIALAVTNMFFVRMVFAWVDRWLSTRRAREAMTGLILLGTVVFQYINVTFNGIGGHTSRAGQAAAQAAKLARVEHLYQAASPLLMHLPPGLAAAAILDQTLHSPSLAVIQILGIGLFGAFFLAVFAWRMQFEFGGENLSEANVSPEAAPRGSHIVVETPAPVRTYGLSPIVAACLQKEFIYLRRNAAQYYGLLVPIAMVFVFAGRAGSFGRTGFTFPAAVVYSFLGISTLSYNALGLDAAGVQGYFLAPIRMRSVFIAKNIFAFGLAALQLVLIYALLFFTSGPPPALIAIETVCWLVFATFANVTIGNMRSLTSPKKMDPSKLARKQASQMSALISIGFMLIAAGIGAGLYLLGKALELPWLPIPALLALAAGAIALYAAGLNRVDAMAYTHREIILEELCKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WWU8</accession>
    <name>E8WWU8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0354</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578754.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0354"/>
    <dbReference type="EnsemblBacteria" id="ADW67426">
        <property type="protein sequence ID" value="ADW67426"/>
        <property type="gene ID" value="AciX9_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0354"/>
    <dbReference type="HOGENOM" id="CLU_887860_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="313" mass="32697" checksum="AFA417A5D516D547" modified="2011-04-05" version="1">MRVGWVGGFLVVLGGVAGAQGVTARAADVREVHVAVQLRTENGDPVTDLEARDFKVLAGGSMTLPGEVRQPVEGAHHQAAGVPTRLLVVLQNVDPEGRASVGAKLGKVWKAGWSVSVLDAQGMESGYVSSAPALRLALAGVERRSSPRAAVGRLTSFAGRRVVFVVTQPGAALGGPTARGLLQSGVTVYHVGGNPLIQESTDENASMSPPVTNGATDAVNGGIVIPGGLSTYRKRGRETEEGSFSGAVRDALNDANGYYDLKVAVPVNVREVELGVRPKGREDEVRYVYAEPYEEGGLPPAVRVMNGKAWGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX05</accession>
    <name>E8WX05_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1513</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579885.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1513"/>
    <dbReference type="EnsemblBacteria" id="ADW68566">
        <property type="protein sequence ID" value="ADW68566"/>
        <property type="gene ID" value="AciX9_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1513"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_1_0"/>
    <dbReference type="OMA" id="DLDQFQA"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="418" mass="46863" checksum="62B285BBE9B8A1D9" modified="2011-04-05" version="1">MDARAGYELGWMFIDINAYFATVEQEERPELRGRPIGIVPVQAESTCCIAVSYEAKAYGIRTGLRVSAARALCPQLELVLARPRLYVEYHHRIKAAIERCVPVQQAMSCDEFACRLMGRECEVERAVEIAEAVKEEIRGVGRTIRCSIGIGPNRLLAKIAGEMQKPDGLTVLERRGLPQSLYGLELHRIPGIGRRMERRVHGAGVQTMEQLCALPRDAMKRIWGGVWGDRMWLWLRGEDFLEPAPPKVPQSLMRQHILPPNCRTYEQGRAVAIKLMHSTARKMRMQGLWASAIYLRVGYMGKRYAYDAHVNLVSCQDPYILQAHMIDLWNSSPSADRPADLTVALTGLTSEPPVELFETAPNARSKVVSSLDALNGRFGLNTVYFGSIHNVRKEAPTRVPFGPPPALSEFRDTADPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX52</accession>
    <name>E8WX52_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581009.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2670"/>
    <dbReference type="EnsemblBacteria" id="ADW69694">
        <property type="protein sequence ID" value="ADW69694"/>
        <property type="gene ID" value="AciX9_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2670"/>
    <dbReference type="HOGENOM" id="CLU_2154808_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="111" mass="11819" checksum="28B5715EF6A5567A" modified="2011-04-05" version="1">MVDQINAIQKPTQIQPEPVDKPTNVQAQAETHNTATQPSKTQKVEEAQAKHVREAYTVHLTTTAKVEALKQVGASVNSISASLGLTRADVDSTLEITDTTVADAETAAVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX61</accession>
    <name>E8WX61_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2679</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2679"/>
    <dbReference type="EnsemblBacteria" id="ADW69703">
        <property type="protein sequence ID" value="ADW69703"/>
        <property type="gene ID" value="AciX9_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2679"/>
    <dbReference type="eggNOG" id="ENOG502ZRYN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1728799_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230401" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="151" mass="16083" checksum="2B5388DF99BD9CC4" modified="2011-04-05" version="1">MRRFAATLLLSASLSMGYAACQGTAHPLPKPVFIAKTIVILNNTHNEAVEQGAVEALKRWGKFTIVDDPDLADITLTFDKKSEHDGTSSQKPDKDGNPSSSYSMSFSSSIHMHASLKGASGSFYNATTTEGKKKAGAECIVDLQQAYASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXK9</accession>
    <name>E8WXK9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) iron-sulfur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_1572</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579944.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1572"/>
    <dbReference type="EnsemblBacteria" id="ADW68625">
        <property type="protein sequence ID" value="ADW68625"/>
        <property type="gene ID" value="AciX9_1572"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1572"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_3_0"/>
    <dbReference type="OMA" id="KCPHKGG"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="103" mass="11316" checksum="41129DE624D07EF7" modified="2011-04-05" version="1">MAQWVRLFGVGEGPEEGKVMEAEVEGVSICVAKTGGELCAVDNWCPHRRGPLGQGWMEGNAVVCPWHSWAFDVRTGIADYPEKERVDVFPLKVEGDDVLVDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXQ1</accession>
    <name>E8WXQ1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_1614</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579986.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1614"/>
    <dbReference type="EnsemblBacteria" id="ADW68667">
        <property type="protein sequence ID" value="ADW68667"/>
        <property type="gene ID" value="AciX9_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1614"/>
    <dbReference type="eggNOG" id="ENOG5033759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134959_0_0_0"/>
    <dbReference type="OMA" id="AWSTRVE"/>
    <dbReference type="OrthoDB" id="1903220at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="DUF4149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4149" evidence="5">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="168" mass="18130" checksum="EFE9892643710BB1" modified="2011-04-05" version="1">MNQALRLGQLIAMVIWVGGLIFFAFVLAPTAFSVLPTVSLAGSIVGAALRELHVLGLICGALFLAVTGVMFSQAPMKVRGRYEMEFLLAGVMVLATAYLQWNVLPAMEVDRGRANGDISSVSVDHPARVHFDRLHKRSERVEGFVLLCGLGVVFLMSRELGGTENKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8WXT8</accession>
    <name>E8WXT8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="12">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
            <shortName evidence="12">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">leuC</name>
        <name evidence="14" type="ordered locus">AciX9_2759</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="12"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581098.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2759"/>
    <dbReference type="EnsemblBacteria" id="ADW69783">
        <property type="protein sequence ID" value="ADW69783"/>
        <property type="gene ID" value="AciX9_2759"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2759"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_0"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="OrthoDB" id="749418at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADW69783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="497" mass="53679" checksum="DB33FE18B9D36AB7" modified="2011-04-05" version="1">MQTNITTPRTLFEKVWQQHLVVAPANEPSILYIDLHLVHEVTSPQAFDGLRMANRKLRRPDRTLATVDHNVPTSSIQDRLHILDPIANRQIEALRQNCADFGVQLFDVQAPEQGIVHMIGPELGATKPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLPQDKPKTFRITVDGELPYGVTAKDIVLHIIGEIGTAGATGHVVEYAGSAIRALSMEGRMTVCNMSIEAGARAGMIAPDQTTFDYLRGRRFSPALTIPNIPMDPAQFGKAMKGATSPWNEAVAQWSTFVTDEGATFDRELFIDATRLTPTVTWGTSPGMVTGIDSNVPTLPAGASEADQKGFERALEYMDLKSGTPMQEIAVDRVFIGSCTNARIEDLRAAAALVRGYHVATTVKAMVVPGSQSVKAQAEEEGLDHIFTTAGFDWREPGCSMCLGMNPDILAPGERCASTSNRNFEGRQGRGGRTHLLSPVMAAAAAITGHLTDIRTWEFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY27</accession>
    <name>E8WY27_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_0494</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578894.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0494"/>
    <dbReference type="EnsemblBacteria" id="ADW67566">
        <property type="protein sequence ID" value="ADW67566"/>
        <property type="gene ID" value="AciX9_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0494"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400467_0_0_0"/>
    <dbReference type="OMA" id="YYDSGYI"/>
    <dbReference type="OrthoDB" id="250274at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233477" evidence="2">
        <location>
            <begin position="19"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="635" mass="68202" checksum="C0C6E7E4E7D6E71F" modified="2011-04-05" version="1">MMLIALQVMAAMPLSANAQSAGSTAPATTTPIKHVIVIIGENRTFDHVFATYKPKEGETVNNLLSEGIVKANGKPGPNYSLSAQFSALDNTTSGTGSYSNSPQSKSIYGTLPPALAGGPIKPTVAGPAPFTTLKVARLADTGLASGYEPYLLTGATGITGGKLDTRITGAATLKEGVYQLSGSNMPYDAYTASPVHRFFQMWQQTDCNADYATKENASGCLNDLFPWVETSVGTGSNGAAQTKGFTNTSTGEGSAAMGFYNMAQGDAPYFRELADKYTISDNFHQSVMGGTGANHIMFGFADAIWYSNGAGQALVPPSNQIENPDPQPTTNNYYDQDGYGGGSYVDCQDIGQPGVPAVTNYLQSLKRPVSPNCDKGHYYLVNNYNPGYNGDGTLASAYSPFTIPPTSVKSIGDSLIAKNVPFKYFGENWDLYVTDPTESNSFDEYCNICNPFQYETSIMGTQATREQYIADTTQLYEDIDTGNLPPVSIVKPSGFNDGHPASSKLDLYEGFVKKIVNQVKANPTLWADTAIFVTFDEGGGYYDSGYIQPVDFFGDGTRIPLIIVSKYTEGGHVSHEYGDHVSLIKFIEKNWGLSPITTRSRDNLPNPTQKANNPYVPTNSPAIGDLVDNFSFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY48</accession>
    <name>E8WY48_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_1623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579994.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68675">
        <property type="protein sequence ID" value="ADW68675"/>
        <property type="gene ID" value="AciX9_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1623"/>
    <dbReference type="eggNOG" id="ENOG503304C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190802_0_0_0"/>
    <dbReference type="OMA" id="ININLIW"/>
    <dbReference type="OrthoDB" id="2067421at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="86" mass="9653" checksum="A2EDF0A7ED63AC7A" modified="2011-04-05" version="1">MGLDIRIPLGLIFLITGGIMALYGFVTRHDAALYAPSMGVNLNLTWGALMAVFGLVMFLVGRRQKWQDDPVTPRPWERDATTKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WY73</accession>
    <name>E8WY73_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580019.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1648"/>
    <dbReference type="EnsemblBacteria" id="ADW68700">
        <property type="protein sequence ID" value="ADW68700"/>
        <property type="gene ID" value="AciX9_1648"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1648"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634488_0_0_0"/>
    <dbReference type="OMA" id="FHESMAD"/>
    <dbReference type="OrthoDB" id="1093214at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="468" mass="51014" checksum="3D3E0DD14BFBCAC8" modified="2011-04-05" version="1">MRATRTLSQRNRPGTKPTSPARLTCLLIAGLSVPAFHQAEAQLSLSTAVDLALTNNPRVKAAESDSAKAAAALAATHDIYVPSLNAGAGLGESYGYSPNPPTLFTFSAQSLVYNAAQFSYIRSAHSGLEASNLALQDVREAVAEDAALTFVALDHDQQREAVLRQQAEYSMKLVSIVLARVDAGKDTAIDLTQARLTGAQFRLALHRAQDDTENDRTHLQRIMGVPVTTVTAEGGFPTTPLPTDSNSLPGGAPNAGVAAAFFTARAKQQQAFGDARFLYRPQFSLIVEYNRYATFTNSFQQLQSNNKNAINANEEVIGVQITLPLFDRYRKDKARESAADARHSLHEAENAQITVLDAQTKLNHTILELQDRAEVASLEQQLAQQQLDVLQLQLNSTTPGAAPQMTPKDEQNSRISEREKYLGVIDTSFQLHQAEISLMRQTGRLEQWLRRSSLTTSPAPSSPLQPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE9</accession>
    <name>E8WYE9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2832</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581170.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2832"/>
    <dbReference type="EnsemblBacteria" id="ADW69855">
        <property type="protein sequence ID" value="ADW69855"/>
        <property type="gene ID" value="AciX9_2832"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2832"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_0"/>
    <dbReference type="OMA" id="VVERSWC"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="224" mass="23762" checksum="F467B256A9B90D43" modified="2011-04-05" version="1">MSEVAIEIKGLLFDMDGVLISSIASVNRCWKLWAAHYGVADAQNVQIAHGVRAVDLIKGYKPGFTEAEVTEGLRYIEDLEIADTEGLKVLAGVRELLASLPPERWTIVTSATRRLLLGRLKAAGLPYPDRLIAADDVVNGKPHPEPYMKGAEILGFSTKGCVVVEDAPSGVGAGVAAGARVLGVLGTHTAEEIYAAGATWVARSLESVKVTVVEGGLRVEFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYM4</accession>
    <name>E8WYM4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_0550</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578950.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0550"/>
    <dbReference type="EnsemblBacteria" id="ADW67622">
        <property type="protein sequence ID" value="ADW67622"/>
        <property type="gene ID" value="AciX9_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0550"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_0"/>
    <dbReference type="OMA" id="WAINSYT"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW67622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="531" mass="56959" checksum="C3530A6529A3996B" modified="2011-04-05" version="1">MAGPEATSDQWKPRVNPWLIAATVALAAFMEVLDTSIANVALPHIAGNLGASEDQGTWVLTSYLVSNAIVLPAGAWASSVIGRKNFFLSCITLFTIASFMCGLAPSLPILLLARVIQGIGGGGLQPMAQAIMADSFEPKKRGQAFALYGLVAVLAPSIGPTLGGWITDNYSWRWIFYINIPVGILAFILVTRFVDDPPWLKPDRANLRKLDYIGLSLLTLAMGGLQIALDKGEENAWFASNFIRFFAAMFVFGMAGLIYWEWNSKAPIMNIKLFKYKNFAICALLMALVGGVLNASTVLQPQFMQQLLGYTATIAGMALTGGGIALVVVMPLAGIATGKFAARNLAAIGFIFFAGAFWWNSITLNLGLSFGYNAFLRVILMIPIPFCFISITNAAYVGLPREASNQVSGIINFVRNVGGSIFIALTGAEVTNRSLFHQAQLQNHMQPGSMGYMSALNGLIGLFKGTTGNTADATGLAQASIYQQLQQQAAAMAYQDIFRLLCYMSIVMIGLAFLLSKNKPGEGAPAGEAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYT0</accession>
    <name>E8WYT0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_1718</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580085.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1718"/>
    <dbReference type="EnsemblBacteria" id="ADW68766">
        <property type="protein sequence ID" value="ADW68766"/>
        <property type="gene ID" value="AciX9_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1718"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="TMTERFN"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="61"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="376"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="409"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW68766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="633" mass="67985" checksum="D530B6DFAD76D578" modified="2011-04-05" version="1">MAGLFNSSSLNGGMPSADRPSRGTGKATVAALTAGRPKPGLKKVWPQIWALVKPRMGLLGISFALMVVNRACGLVLPASFKSLIDGVMTHHDLKLLPKIVGFVVGATVLQGLTSYLLTQLLSKAGQRLIAELRMQVQSHIGRLPVSFFDENRTGTLVARIMTDVEGVRNLIGTGVIDFFGGVLTAIFAFCYLISLSVKMTALTFCILVAFALILQRAFNTIRPIFRERSKINADVTGRLTESLGGVRVVKGYHAEESEARVFGAGVGRLLDNVLSSIRAQSFMSLASTTVLGVVTALIMYLGGHEVVAGKLTTGGYVTYMAFLAFMVAPVAQLVSIGTQLTEAMAGLDRTTEILGEMEEDGGPERRVTLDTIKGDVVFEDVLFEYEAGKPVLHGIGFESKPGTVTALVGSSGSGKSTIISLVCGFHVATGGRILVDGVDLGTVRLSSYREQLGVVLQETFLFDGTIRENVLFSRPNAGEGRLIEACRIARVDEFAERFPEGYDTIVGERGVKLSGGQRQRISIARAILADPRILILDEATSSLDSESEAMIQGGLNHLMKGRTTFVIAHRLSTIRKADQILVVEQGNIVERGTHESLYALGGRYFDLYTRQHGLETNLFLAPGEGDKVEAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYU6</accession>
    <name>E8WYU6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1734</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580101.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1734"/>
    <dbReference type="EnsemblBacteria" id="ADW68782">
        <property type="protein sequence ID" value="ADW68782"/>
        <property type="gene ID" value="AciX9_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1734"/>
    <dbReference type="eggNOG" id="COG3844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_0"/>
    <dbReference type="OMA" id="TFPTDGY"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="66"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="388" mass="42649" checksum="FFAE91F4EB225F3F" modified="2011-04-05" version="1">MTDRDPLLKWRAEFPILEHTTYMISHSLGPMPRRAITALADFTTIWATRGIRAWEEGWWDMPVTCGNLIGKIIGAPEGRVIMHQNVSICQQIVTSCFDWSDNKRNKLVTDGLNFPSNDYIYHGLSRQGARIVSIPPNPDGLTVPLEDILNAIDNETQLVSISHVAFRSSALQDLAAITEKAHAVGAYIVADLYQSAGIVPLDVTALNVDFATGGSVKWLLGGPGAGYLYVRPDLDLKLQPANIGWAAHAHPFDFAPGPIQYAPDMMRYSNGTPNVPAMYSARSGYEIVAEIGVPAIRAKSQRQTQHMITLADAADITVRSPRNPNHRGGAVILQVPEHEGRNIVAELARRQILIDFRPGAGIRIAPHFYTSDDEIAHTITELKSILKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ03</accession>
    <name>E8WZ03_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2895</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2895"/>
    <dbReference type="EnsemblBacteria" id="ADW69918">
        <property type="protein sequence ID" value="ADW69918"/>
        <property type="gene ID" value="AciX9_2895"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2895"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_0"/>
    <dbReference type="OMA" id="NQYVRLV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233505" evidence="1">
        <location>
            <begin position="25"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="73"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="550" mass="61050" checksum="F2A8667CCDD5ACDB" modified="2011-04-05" version="1">MKRPLKTIWSLPLVLLAGLQPSYGQPPNHAELAWSLKYDPKTLDPAKVDDQASETLRFLTGGVLLRMNRQTQEIQPALAASWSVSPDGRTATFHLRAGLRFSDGSALTSADVVSTLKRVLDPATAAPVAEEFLTPAQVTVEAVDPLTIRIHLPTRIVALGKIFDEIAIEPANHPSASRITAGPYTLAEYKRGESLRLQRNPYYYKRDAAGAQLPYLSTLHLDILANREQDQMRFVRGQYQLIDGLAAENFKLLSQGNAANMHDLGPSLNTEQMWFNQAASAPIPDYEKAWFQSRSFRTAVSLSIHRADMARIAYDGHATPANGFVSPANTMWHNNQLKPIHEDTNAALQMLASEGFHKTAGQLVDRTGHPVKFSILTNTGNRSREKMAQLIQQDLSSLGMTVNVVTLDFPALIERLMHTQSYEAALLGLSNVEPDPSSMMNVWLSSSPNHQWNPSEKKPATDWEAELDQQMKLQAEAPNQKARKLAVDRVQQIVYDQLPFIYLVYPNALYAVSSSLSGVEFSVLQPGVVSNIDQIRWKDSNVTDNARGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ41</accession>
    <name>E8WZ41_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">AciX9_2933</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581271.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2933"/>
    <dbReference type="EnsemblBacteria" id="ADW69956">
        <property type="protein sequence ID" value="ADW69956"/>
        <property type="gene ID" value="AciX9_2933"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2933"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_0"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="249" mass="26326" checksum="3EF87E720B0AD703" modified="2011-04-05" version="1">MAIMLKTPQEIEKMRRSGRVLRQVHDAIKPLVVAGATTMDLEIAANAKIDSFGAKAAFKGYHGFPAALCTSLNHQVVHGMPNKDTVLKDGDILSIDCGVIVDGYYSDAAVTYAIGTPSAKTKKLLEVTEASLEAAILEAVVGGRLGDISAAVQEMCEAQGFGVVREFVGHGIGKAMHEDPQVPNYGSRGKGPRLKAGMVLAIEPMINAGAAEVKVLKDGWTAVTVDGSYSAHFEHTVAITKDGPQVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ48</accession>
    <name>E8WZ48_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ordered locus">AciX9_2940</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581278.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2940"/>
    <dbReference type="EnsemblBacteria" id="ADW69963">
        <property type="protein sequence ID" value="ADW69963"/>
        <property type="gene ID" value="AciX9_2940"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2940"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_0"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="19324" checksum="1BD1C813FFD94DA4" modified="2011-04-05" version="1">MSRIGKKPIALPAGVKYTVDGNTVLVEGPKGKVTALVPTGITLVKKDNELLVERENDSLAGFHGLARALVFNAVTGVTTGWTKELDIVGIGYRAELKGKDMVVFTLGYSHPIEFPLPTGIEVTIDAKQLHLTVSGIDRQKVGQIAADMRSLRKPDPYKNKGVRYTGEKLKKKVGKTGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZ81</accession>
    <name>E8WZ81_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S53 propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0612</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0612"/>
    <dbReference type="EnsemblBacteria" id="ADW67683">
        <property type="protein sequence ID" value="ADW67683"/>
        <property type="gene ID" value="AciX9_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0612"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012501_0_1_0"/>
    <dbReference type="OMA" id="ASEGWDA"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S53" evidence="5">
        <location>
            <begin position="183"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW67683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="567" mass="57984" checksum="A04A14556149002F" modified="2011-04-05" version="1">MAATPRFASQPRVTLPGSQKHPLTTDTEVPPPAPVKAAATKLSATPFTVTVIVKRKNPLNLKQVLKPAGRLTHAAFAKAHGPSPDGVKLVKAFAKEFGLTVAPAPGQGRRALYLTGTAAAMQTAFGVTFATKIMEGTKYRVREGDICLPKELIGHVDAVLGLDNRPQAKPHFRHHKPAATSVSYTPVQVGQLYGFPSGAKATGQTIGLIELGGGFRAADITAYFKTLGQTAPKVTAVLVDKAKNTPTTSSSADGEVMLDIEVAAAVAPGANIAVYFAPNTDQGFIDAISQAVHDTVNKPSVISISWGGPESTWTAQSLAALDAACQSAAALGITITVAAGDDGSTDGVKGTVNHVDFPASSPHVLGCGGTKLLGSGTTITSEVVWNELTANEGATGGGVSNVFPLPTWQAKSNVPKPTVAAGGRGVPDVSGNADPSTGYTVRVDGSTFPIGGTSAVAPLWAGLIALCNAQNKTTAGFINPALYAAAAAKSFRDITSGNNGGFKAGPGWDACTGLGSPIGTAIAKTLAPATKSTSKTAVKNAPEIRFRPHKKAPTKTAAKTPALRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZB4</accession>
    <name>E8WZB4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67716">
        <property type="protein sequence ID" value="ADW67716"/>
        <property type="gene ID" value="AciX9_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0645"/>
    <dbReference type="HOGENOM" id="CLU_808366_0_0_0"/>
    <dbReference type="OMA" id="MSGHREV"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="343" mass="38459" checksum="1894F1887951A93D" modified="2011-04-05" version="1">MTRNELFWRNLWVAVRRLRIPVSVHLLWIVPIWLWLFVYCLQGWGVRGFWRTAAWIASILLTFFVPALLLHAFRITGEALRRHRGRPQPADIDMSGHREVLKTLMLQVAALVDRAGGEALTRGGHVKGSHAGACRRRTLDLAQRPELWEGFSEDERGLLLAQEGGWAWETVWPMVVRAEDVRALRWVLGMDRILVPLEYLKPDLRPVVEVTSKPEMAEGTVCLPAWELGQALRLAQAMVSRCVVEGVKRGFLTEMEPEVRAEYVSMAEELGENESEDLLIGSATVGTADTAKVQWVAQAALRRAYVLEGVARYLNGPADGRLRIVAEVVGADEGQGGDERARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZF8</accession>
    <name>E8WZF8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tdh</name>
        <name evidence="8" type="ordered locus">AciX9_1798</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580165.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1798"/>
    <dbReference type="EnsemblBacteria" id="ADW68846">
        <property type="protein sequence ID" value="ADW68846"/>
        <property type="gene ID" value="AciX9_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1798"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="OMA" id="QFGVADY"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="344" mass="37573" checksum="5CAA109717752E20" modified="2011-04-05" version="1">MKALVKSQDGQGLWLKDVPEPEMGINDVKIRVLYTGICGTDLHIYEWDAWARSTIQIGLVIGHEFVGEVVAVGENVPDVHPGQLVSGEGHVVCGRCRNCLAGRRHLCAFTKGVGVNRDGAFAEYVVLPMSNIWHHAPGVNPEVASIFDPFGNAVHTALAFPVLGEDVLVTGAGPIGIMAAAVARHAGARHVVISDPNPYRRALAEKLGVTRAVNPMETTLAAVQKELGMSEGFDVGLEMSGNPNAFRDMINSMSHGGKISMLGIPSQEIAIDWNKVIFNQLTLRGIYGREMYETWYKMTVMLESGLDIEPVITHRLNWRDYKDGFDAMRSGNSGKVVLDWRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN2</accession>
    <name>E8WZN2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2983</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581320.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2983"/>
    <dbReference type="EnsemblBacteria" id="ADW70006">
        <property type="protein sequence ID" value="ADW70006"/>
        <property type="gene ID" value="AciX9_2983"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2983"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_0"/>
    <dbReference type="OMA" id="MSIIPAG"/>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="347" mass="37835" checksum="C9672D3657411530" modified="2011-04-05" version="1">MKKALPWAIGAALLTFIAWKLYSSHFDWHSFAQSWRTADWRLLLIAITVIYLQDVLRAVRWAIFLRPAFKQTQLKPTHWYSLVGSQFVGFTGLAIFGRIGELIRPLLVSRRTGLTFSSQIAVVAVERVFDLGAFALIFSLNLLFSPSLQSLPYHELFHKVGYAIAALTLFLVIFVASVRLAGSAVATLMGKFVGMASPKAGAAITDRILSFRDGLNVIDTPADFTAVTLLSLLTWGLIAVSYVVIMKSFPPPVHDLTISHILVLMGFSVVGSLVQFPGVGGGAQFASITALTLLFGIPKELAVSAGLMLWLIQNMSIIPAGLIFARIEGISLRQAAHTTETKESSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV0</accession>
    <name>E8WZV0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0691</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0691"/>
    <dbReference type="EnsemblBacteria" id="ADW67761">
        <property type="protein sequence ID" value="ADW67761"/>
        <property type="gene ID" value="AciX9_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0691"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034186_0_0_0"/>
    <dbReference type="OMA" id="HEAVGHR"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233539" evidence="2">
        <location>
            <begin position="30"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="327"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="598" mass="64613" checksum="90DEFCB9E8432056" modified="2011-04-05" version="1">MNKRVAVNRVTQSLLTAFLVGQTAFGASAAASGPDKKPAASGAQDPVLIQTMQAELTRAMSSLGSAAASTAGSPPPPKPYFMSYAVSDAENVSISAQFGAITNSNETRRRNADIQVRLGDYAQDNTHGDHRTSALTTVPLPLTDDREALARSFWFATNRGYGKALDSYLKVKTEQQVRAKEEDASADFSHETTSQEFVPSDAKFSPAAPLMKDKSAWEERLRELSGLFKQFPDIFSNTVALDASNEVDYFIDSDGTRISTPSHVARIVVVARTRAADGMDLFRVETFESDELGRLPDQKTLTEKTLAMAKNLEELRVAPVTEPFDGPAILSGRASAVFFHEVLGHRLEGQRQRGDEEGQTFTKLLNKPILPTFLSVADDPTLKTFDGISLSGHYSFDDEGQPARKVDLIQDGVLKTFLMSRLPIASFSASNGHGRSEAGHMPTGRQGNLIVTSSKSVSEPELREMLKAEAKKQNKPYGLYFEDISSGFAVTSRRSPQAFSVIPLVVYRIYVDGRPDELVRGVSIVGTPQAALSRIVATGNHQDVFNGICGAESGSIPVSAVAPAMLVSEIETQRQAQGSSRPPIVPPPAVAKMSEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZV2</accession>
    <name>E8WZV2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0693</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0693"/>
    <dbReference type="EnsemblBacteria" id="ADW67763">
        <property type="protein sequence ID" value="ADW67763"/>
        <property type="gene ID" value="AciX9_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0693"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_3_0"/>
    <dbReference type="OMA" id="VWNEDKT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="90"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="2">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="407" mass="42839" checksum="88AF4FE754E6FDA8" modified="2011-04-05" version="1">MSIEQREADTGSIAGKVLPAMRRANLTHAITLSLGMLTLAGCHQQETNKQAAEAPPSVPQVVPAGQANVVHVDQANQFPLVTTTSRTVFSTLNVTGAVQPDVSRELPVLSIANGRVVALHVGLGDYVKKGQLVMEVQSPDVTTAFGNYLKAVSDEHLTQTTLTRDKLLYDKGAIAQSQLEVAQNGEEDSQSALTATEQQLHILGVDKNHPSELVKVYAPITGVVVSQNTTTAGAAGITFAGAAGSLTIADLSHVWVVCDVYENDLPNVRLGEAAQITLNAFPGKVRTGTISDIGAILDPSIRTAKVRIQVQNPDNLLRIGMFATATLKGATPKQTVAVPANAILHLHDRDYVFVPAGSAGDFRRQEIKSGGSLPGDSTANYIEVLNGLAAGQQVVGNALELQNTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX0</accession>
    <name>E8WZX0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0711</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579107.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67781">
        <property type="protein sequence ID" value="ADW67781"/>
        <property type="gene ID" value="AciX9_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0711"/>
    <dbReference type="eggNOG" id="ENOG5031IUI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173065_2_1_0"/>
    <dbReference type="OMA" id="QVQHITA"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="60" mass="6728" checksum="11A6C0B4DFD5E145" modified="2011-04-05" version="1">MKKSPKLDTLTSRPNLDYSKAAHGKYFDRMQRGTNIILLAPDFVATFPDSQSANEALRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZX5</accession>
    <name>E8WZX5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0716</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579112.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0716"/>
    <dbReference type="EnsemblBacteria" id="ADW67786">
        <property type="protein sequence ID" value="ADW67786"/>
        <property type="gene ID" value="AciX9_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0716"/>
    <dbReference type="eggNOG" id="COG3137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651563_0_0_0"/>
    <dbReference type="OMA" id="HYEKQQF"/>
    <dbReference type="OrthoDB" id="845346at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007433">
        <property type="entry name" value="DUF481"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04338">
        <property type="entry name" value="DUF481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230504" evidence="1">
        <location>
            <begin position="17"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="372" mass="40250" checksum="B74037D39E838887" modified="2011-04-05" version="1">MRALIFVLLLASSLYAQTPKTPDSLVFVNGEQLTGTLEKADSKGITFKSLMAGEITVGWANIKELRSDQQFAVLTTNEKLTRRNAAAVVPSGRISVADKQLVVATKEGPKVVPIEKADRLIDAAAFDKAINHPQGLLQGWGGTAVGGVSLVRATQDSTTFTGALSLARATPTVDWLPARTKDSIAYNQSYGTSSQALTPTIKSNIFHANAEHDRYFSPRLFAFGAATFDHNYSQLVDLEQAYGGGVGITVIKNAKHELDFKGDIHYEKESFFTIDGSTPAPNLNLAGSTFSETYLRHLLKGIVFNEFGSVTPSWNDTNAYSAHVNAGFVFPVIKGFGLNINGIDDYLNNAPFGSKKNSVQYSTGITYTIKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0D1</accession>
    <name>E8X0D1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative addiction module antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579121.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0725"/>
    <dbReference type="EnsemblBacteria" id="ADW67795">
        <property type="protein sequence ID" value="ADW67795"/>
        <property type="gene ID" value="AciX9_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0725"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137365_3_2_0"/>
    <dbReference type="OMA" id="EANGGMA"/>
    <dbReference type="OrthoDB" id="2002329at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="99" mass="10473" checksum="BA09747BDEFF9CC0" modified="2011-04-05" version="1">MPTISHDESMAQVFREDPAYALDLLNSILEDGEPAELLIALRQMTKAFGGVQAVAESSGLNATQLYRTLSADGNPALSTLTAILKTMGLRLAVTPVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0E4</accession>
    <name>E8X0E4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_0738</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579134.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW67808">
        <property type="protein sequence ID" value="ADW67808"/>
        <property type="gene ID" value="AciX9_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0738"/>
    <dbReference type="eggNOG" id="ENOG502ZSJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158027_0_0_0"/>
    <dbReference type="OMA" id="YLVWARY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW67808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="132" mass="14593" checksum="31EDD79D22432870" modified="2011-04-05" version="1">MPIDEAPAIPGLGRLAMNGWSSRLMIAGMGFLLAGVPGRAQDTHPRDLIGTVTDHGSREPLKGAVVLLENESSKEITSYLTDAGGNYLFKRLRNDTDYLVWARYRGKESKQGELSHFDSNQHPVIHLVIELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0I4</accession>
    <name>E8X0I4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0779</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579174.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0779"/>
    <dbReference type="EnsemblBacteria" id="ADW67848">
        <property type="protein sequence ID" value="ADW67848"/>
        <property type="gene ID" value="AciX9_0779"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0779"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_1_0_0"/>
    <dbReference type="OMA" id="HCPYVKH"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="211" mass="23170" checksum="14C1B5404D4DF1E0" modified="2011-04-05" version="1">MSKTESTMVELGTVAPPFELRDVVSGRAMGRDDVLALAWDDAMSDQTNLTAGSGAPKSGRHGLLVMFVCVHCPYVKHVEVELARIGVDYQGKIAIAAISSNDIVAYPQDGPEEMKKQAERLGWRFPYLLDESQEVARSYDAACTPDFFLFDAGMRLVYRGQLDGSRPRRGDSGNDEPVTGVDLRRAMDEVVAGRTPGVEQKTSLGCNIKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0N6</accession>
    <name>E8X0N6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580306.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW68987">
        <property type="protein sequence ID" value="ADW68987"/>
        <property type="gene ID" value="AciX9_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1941"/>
    <dbReference type="HOGENOM" id="CLU_1105921_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="251" mass="28463" checksum="C938AA91B9FD1DFD" modified="2011-04-05" version="1">MASVTVTGLRSILISLANSWDLRHPSESKHQQALCDCAKLFTDPAFEQQPGDTEQQSETRESERLQVFRVLEEYGGSFGGPYQEARSEAPTTYIHAYTAFVRACLLRPWKSAISEREEVFTEVRGHLWANALGRGRWDELPKDHLLRKLLERFQVDLPLLRVCANPACRRTRRLFIATKEARVYCGTDCAAEGESLRLKKVVRKGRTQAAGETNKGPKSVEGRARIAAAQRKRHAEKRAKTKKRPNIYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0Y1</accession>
    <name>E8X0Y1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3153</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581478.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3153"/>
    <dbReference type="EnsemblBacteria" id="ADW70165">
        <property type="protein sequence ID" value="ADW70165"/>
        <property type="gene ID" value="AciX9_3153"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3153"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="GLNHAQP"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="279" mass="30181" checksum="94A85BD07683F2E0" modified="2011-04-05" version="1">MSQVWLITGSSRGLGREFAIAALEAGHKVAATARKVSDLEDLQKTYGENVLPIALDVTNEAQAYEAVQSTIAKFGRLDVLVNNAGYGNVAPVEDTSLAEFREQIETNLFGTIILSKAALPHFREQKSGHFIQVTSIAGRMGPIGRAPYAAAKWGVEGFSETLAKEVAPFGVKVTLVEPGGFRTDFAGASTSLQEGRPEYDETVGKTARFQRDFNGKQPGDPKRAAAALLKIASEQNPPFRLIVGSDAYNAIEKNDLAKMEAAKEWKELSIFTDFPKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X179</accession>
    <name>E8X179_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_1987</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580352.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1987"/>
    <dbReference type="EnsemblBacteria" id="ADW69033">
        <property type="protein sequence ID" value="ADW69033"/>
        <property type="gene ID" value="AciX9_1987"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1987"/>
    <dbReference type="HOGENOM" id="CLU_2342809_0_0_0"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10989" checksum="9C235BA74FCA5BF4" modified="2011-04-05" version="1">MDERTIVSVADEQQAGQVNEVRQHDLRFLAQWKSIEEYPACPVGIGILKQMAEASPGAYELALSKGMDRPDHPLLIRNPHWRAFVAHYQACENCNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1F0</accession>
    <name>E8X1F0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative relaxase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581497.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3174"/>
    <dbReference type="EnsemblBacteria" id="ADW70185">
        <property type="protein sequence ID" value="ADW70185"/>
        <property type="gene ID" value="AciX9_3174"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3174"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001748_0_2_0"/>
    <dbReference type="OMA" id="KESMFEI"/>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027351">
        <property type="entry name" value="(+)RNA_virus_helicase_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014059">
        <property type="entry name" value="Conjug_relaxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01443">
        <property type="entry name" value="Viral_helicase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02686">
        <property type="entry name" value="relax_trwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="(+)RNA virus helicase C-terminal" evidence="1">
        <location>
            <begin position="821"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130539" checksum="A52B75D2D0DDE246" modified="2011-04-05" version="1">MLTISKAISSAQAQTYHKLEYTSDAQSYYKQDETVKGEWQGKLAASLGLSGEVAPLEFSRLTEGIHPQTEAQMVRHREGQEYTNADGSVTKPVQHRAGWDATFSAPKSVSLTALVGGDERVTEAHRAAVTTALEELEKYTHARIGGNNPAEVTGKFVAAKFEHDTARPVNGYAAPQLHTHAIIFNVTQREDGSTRAIQERTFFESQNYATAVYQSVLTHQLRKLGYEIEPGQSGAPQILGFTQAYLDASSPRSRQIKEQMERVGFQGPEAAQIAAHATRDRKQTLTPAEVLAAHKEMAKDFGDQPERVVADARERALTQAQEISVQPDSRGAVAFAKEKVFEREAVADERLIMREALRRGMGEVSFSDVQSEFQRRQAEGEFRSVQGQKYASGRSFTTPETIADERANVQHVLNGQGASAPMLSTAAAERQATSRDFLNEAQQTAIREVLTSTDRIHGFQGLAGTGKTSTLAAIREGAEQGNYKVEGFAPTSKAAGQLREAGIEANTLQSFLARQKAPDSSRHLYMLDESSLASTKQMRAFLEKIHPQDRVLVIGDTRQHQGVDAGRPFQQMQEAGMQTSKLDTIMRQKDPELLRAVQHLATNETEMGIALLTQQGRVTELANASERIAAIARDYAAKPENTLIVSPDNRSRQQINEAVRGELLKAGKLAEDGRQFLTLSHRSDMTGPDRTWAAMYRPGDVVQYERGSKAEGIERGSFGVVRSSDAATNRLTVELPNGVNVEYDPKRVYGVNVYRETSREFATGDRLQFSAIYKDLGISNRDMGTITRMEPDRLTVLMDGKEQRSVSFNPIEFRQFDHGYAVTSHSSQGLTTDRVIANIDTESSRSLINNRLAYVAISRASEDARIYTNDAATLGQRLATDVTKTAALDFTAKPEPRATQEASKARTVAVHEYKNSDSRLAAVATEYVSRPERSVIVALDRAEREQLTQLVRADLYAQGKLGRDAQAISVLIEKATGNKMRVDSYQPGEKIQYKTGSPGLNGIPHESQATVVSTTSRGNLLSIRFDATREEVSYNPGQLRTATRESRVYQEATREVAEGERVRFTRYDKDMGVRSGDLGTVTRIGEDHAMRVKMDSGKIAEVPPEKAQHIDYGYVVDSLKDVRAERVIATGDGLTQQAFQAASSKADLALYTSPPQQEFASSKEIAVTEFAQPTKQQNDFGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N3</accession>
    <name>E8X1N3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">AciX9_0884</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579276.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0884"/>
    <dbReference type="EnsemblBacteria" id="ADW67952">
        <property type="protein sequence ID" value="ADW67952"/>
        <property type="gene ID" value="AciX9_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0884"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_0"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADW67952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="370" mass="38743" checksum="2B0AE9D509A1C863" modified="2011-04-05" version="1">MTIGVPKEVKDHESRVGVTPAGVKALAEAGHKILVETNAGALSAFTDDEYQSAGAEIVGSAYDVWRLADMVVKVKEPVESEYRNFREGLVLFTYLHLAPLTALTDALLEKKVTGIAYETVRDRTGGLPLLTPMSEVAGRMSVQVGATYLEKEHGGRGVLLGGVPGTPPGNVCIIGGGIVGTNAAKIALGMGAHVTIVDMNLNRLRELDDIFAGRLHTLASNSYNIERAVCAADLVIGGVLIPGAAAPKIVTRAMVSKMKKGAVIVDVAIDQGGCIETARPTTHTDPSFVVDGVVHYCVTNMPAAVPYTSTLALTNATFPYVMKLAKMGAQAAIKEDAGIAEGVNTYNGSLTYGAVATAQNRGWKQIAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1N4</accession>
    <name>E8X1N4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">AciX9_0885</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579277.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0885"/>
    <dbReference type="EnsemblBacteria" id="ADW67953">
        <property type="protein sequence ID" value="ADW67953"/>
        <property type="gene ID" value="AciX9_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0885"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW67953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="354" mass="38298" checksum="81094EBEF30E5A38" modified="2011-04-05" version="1">MSSNNFQMRYSRVHNMRSLFSLFSSDLAIDLGTANTLVFAHGKGIIVNEPSIIAVNQITGEVEAVGKEAKEMLGRTPGNIVAIKPMKDGVIADFKQTEKMLNYFIQKAHNRKMMVHPRIVIGVPSEITQVEKRAVMDSAYRAKASEVHLVEQAMVAAIGAGLPITEPGGNMVVDIGGGTTDIAVISLAGIVYSRSVRMAGNQMDDAITTYIKRKYNLLIGERTAEQIKMELGSAFPLDKPLTKTITGRNLIEGVPKTISIDDSEIREALSECIATIINGIRVALERTPPELSADISDRGIVLTGGGALIKNLDKRIREETGLPVSVADDPLASVVLGTGQMLSNFKLLRKISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X1R1</accession>
    <name>E8X1R1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_0913</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579304.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0913"/>
    <dbReference type="EnsemblBacteria" id="ADW67980">
        <property type="protein sequence ID" value="ADW67980"/>
        <property type="gene ID" value="AciX9_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0913"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024435_0_0_0"/>
    <dbReference type="OMA" id="GINHHWT"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233591" evidence="2">
        <location>
            <begin position="21"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="110"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW67980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="490" mass="52108" checksum="D984A7451ED18906" modified="2011-04-05" version="1">MRTHSLALLALAAATLPAAAQTVTGQAAFADYSQQKPGASRKITVGDLPEPKPTESVDNGPTLVEKPTNAWPIAPAGFKVTLYAGGDNSLSQSANKKQVVGPATEGTFREPRLIRTAPNGDLFVSDSAAGTVFVLRGTGPDGKAKVVSQYATGLDHPFGIAFYPAVNPKYVYVADTTTVVRFAYKAGDLKATGAPETLVPNLPGYAQLRGGGHWTRDVVFTKGGEHMLISVGSGSNVDDADTHSREFHRADVLEFTPEGKFVKVYASGIRNCVGEAINPVTGSLWCSVNERDNLGNNLVPDYITSVKEDSFFGWPWYYMGGHRDPRLPLPCANGTGPNHQAPALDEAAAKDCKREDIASKVSTPDILVQPHMASLQMLFYPGGEGTGKTIHASTAFPMSYDGNIFAAEHGSWNRAHRGGYEVIMAPIHAGKAEGSYQDFLTGFVTPDGQVWGRPVGVTVGTDGSLFVTDDGSRSVWHVTYTGSKTTTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X226</accession>
    <name>E8X226_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_3258</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3258"/>
    <dbReference type="EnsemblBacteria" id="ADW70269">
        <property type="protein sequence ID" value="ADW70269"/>
        <property type="gene ID" value="AciX9_3258"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3258"/>
    <dbReference type="eggNOG" id="ENOG50331JK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2825082_0_0_0"/>
    <dbReference type="OMA" id="MHILEGS"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW70269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="68" mass="7520" checksum="10B75AE1D9E6DF59" modified="2011-04-05" version="1">MGMANLVLVYGMRLLPADEVVKVGSAPVELQNGNEAHVTMHVLEGSREEIEAQLKLSVDAFFDFYPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X245</accession>
    <name>E8X245_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3277</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581600.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3277"/>
    <dbReference type="EnsemblBacteria" id="ADW70288">
        <property type="protein sequence ID" value="ADW70288"/>
        <property type="gene ID" value="AciX9_3277"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3277"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_3_0"/>
    <dbReference type="OMA" id="VTISNCV"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230581" evidence="5">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="414" mass="43862" checksum="23B981120E686241" modified="2011-04-05" version="1">MKTGWLAAALLVAGAHGALAKTCDVKTMGAKGDGVTKDTEAIQKAIDTCTVVTLSGGKFLSGPLEIKSGVTLDVETGAMLLGSTDRADYKAATLMRQPTVLPFLHIVNADNVKITGGGTIDGQGKVWWDYVKGAKDAGVLGNDHPRPMGLLIDHSKHVTVENITIQNAGFWQVVPYYSDYLVFSHLRVLAPQRGAPNTDGIDPFSSSHIKIDHYFSSVGDDNIAIKSGAINSPGPDAPSEDIVITDCIFESGHGLSIGSEIAGGVHHVHAERISFKGTDQGIRVKANRDRGNDTSDLTFKDITMDDVRTSILISEYYPKAMPEGEVASAPITRLTPHFHDIHIENVKSVNSDWAGVIVGLPESPVTDISLKNVSIQAKKGMQIGYANVTLDGVTISSADGNPITKGAAAEISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B5</accession>
    <name>E8X2B5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_0980</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579371.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0980"/>
    <dbReference type="EnsemblBacteria" id="ADW68047">
        <property type="protein sequence ID" value="ADW68047"/>
        <property type="gene ID" value="AciX9_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0980"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065993_0_0_0"/>
    <dbReference type="OMA" id="MGGMQTW"/>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230182" evidence="3">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="77"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW68047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="368" mass="40758" checksum="98C3D6FDD5F68CBB" modified="2011-04-05" version="1">MPRTTARLASLLLVASSAFTAFAQAPAHVNKWATIAKEGFYTIPNFKFGTGETLPELKLQYLTLGTPHKDAAGHTDNAVLLLHGTGGNASTLLSPVFSDVLFGPGQPLDITKYYLILPADIGMGESSKPSDGLHMKFPAYDYDDMVRSQQIMLTEGLHVDHLRLILGTSMGCMQSFVWGEAYPEFMDALAPFACQAVELAGRNRMWRYMAIQGIKNDPAWMGGEYKTEPIQGITFANELSIIAGSAPLQMQKNQPTRELAEKFVDQSLARSVPTIDANNYIYYVNASRNYDPSKHLDRIKVPLLWINSADDFINPPELGLAQKQIKEIPKGRFILLPITDATRGHGTHTNAAIWKDDLIQLMKESEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2B8</accession>
    <name>E8X2B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_0983</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579374.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0983"/>
    <dbReference type="EnsemblBacteria" id="ADW68050">
        <property type="protein sequence ID" value="ADW68050"/>
        <property type="gene ID" value="AciX9_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0983"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017999_1_0_0"/>
    <dbReference type="OMA" id="VGHWYEH"/>
    <dbReference type="OrthoDB" id="100199at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW68050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="626" mass="68242" checksum="54ADB1EF81F14076" modified="2011-04-05" version="1">MAIQDVVFGKPLATDEERGEHIGVAAGIPIFGLDALTSAAYGPEAAMSLLIPLGMASVGYILPIISAILILLVIVFFSYRQTITAYPSGGGSYTVATENLGAGAGLLAAAALMIDYILTAAVGISAGVTALTSALPSLQPHTLELCLLILAILVVVNLRGVKDTGTAFIIPTFMFIGTLLTLIGVGVFKTFAAGGHPVPVMTLPQDIEAVHPYLGYAFVWLILKAFSNGCAAMTGVEAVSNGVMAFGEPRAKKAKATLSVIIAILIVLLYGTSWLAKHYQIMAMNPDAPGFQSLLSLLVMAVFGRGWFYYVTMGSVLLALALSANTAFADFPRLTRAIAMKDYLPHVFILRGRRLLFSHGIYALTVFTAFILIAFKGVTDRLIPLYAIGAFMAFTLSQAGMVIHWKKEEKHAGRGWHMFVNGVGALATGITTCVVLVTKFKDGAWVTALLIPALILLMLGVRKHYTRVHSEMQDMAPMNLDNLEQPIVVIPMAGWNRITEKAMRFGLLMSPDIKVVHVHSEDEGEHQLEDDWETKIMVPIREKGLQHPELITIPSNFRFIIAPLMGYILQLETENPGRKVAVLLPELVVRHWWENALHNQRVQLLKLLLLLRGNQRIVVVNIPWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2I0</accession>
    <name>E8X2I0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2160</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580520.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2160"/>
    <dbReference type="EnsemblBacteria" id="ADW69204">
        <property type="protein sequence ID" value="ADW69204"/>
        <property type="gene ID" value="AciX9_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2160"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133163_0_0_0"/>
    <dbReference type="OMA" id="ARNCSAC"/>
    <dbReference type="OrthoDB" id="1469969at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="139"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="248" mass="25775" checksum="8EA281780F0A2456" modified="2011-04-05" version="1">MQPSTGPSRLLWALSLGALSITGCKLPGRPAPGDIPQRPDQVADFKTLYNSNCAACHGSNGQHGAAVSLANPAYLNYAGETNIANITAKGIDGSLMPAFATEAGGLLTDTQIRILAHGMVTNWGRPGATAPAYQSHAVGDIKRGETAYRNDCLRCHAPGNGSLLDPTYLAIISDSGLRTYIVAGKPEDGMSDWTGYGAAPLDDQTITDLVAFLTSHRIQTPGQPYSNGLGEAKPQPQPATSTGKSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2J2</accession>
    <name>E8X2J2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_2172</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2172"/>
    <dbReference type="EnsemblBacteria" id="ADW69216">
        <property type="protein sequence ID" value="ADW69216"/>
        <property type="gene ID" value="AciX9_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2172"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368335_0_0_0"/>
    <dbReference type="OMA" id="WIMFLEV"/>
    <dbReference type="OrthoDB" id="1639526at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="756" mass="81598" checksum="EE0F8B02A124329F" modified="2011-04-05" version="1">MNADSSSRQSKVRFGAFDFDLRRQELRRQGHLIKLPAAQLRLLNLFLERPGELITRDEITAHLWVDTGTIDVSSGINTSINRLRANLSDPQSSAEYIETVIGLGYRFVAEIAAAPSPAPALPEAPAKSEPPVEETPVPPSEVDEVSLPIAETPTAPVTRSNARSIPHRGWLAVCSLVLLVIAGGFFLLRLTRARSATAAMPVTKTASLPFHLRPVTLTAHGETISAVAVSPDGNSVAFSNRAGVSIHTFGGTDHLLPSRPFFQVSRISWFPDGKQLLLSGTDTQTRRHQVLGAILWEGYLRPFADDADLATVSPTGDSVAYTRHNNTELWVADAGGENPRKLLTDARGSFTYLIWSSTGDHLLADRHTTSPDLDSYESIDARSGAVLTHESGLAFPSGYLLEDGRLYFPISGSQNPASGKTRLMMVHTDPRTGKLLEKPQELQTFSGYGGALSASTDGKRIALALDYATVNVFVADLHLPGPTLDNIRELPHKVEESYPHAWTPDGKAVLSESSVLGTWAIFKNPLDAPESQLVAKLPTGAAMAQTSPDGRWIMFLEVSNNVAAPSGIFRVPVAGGEAAQVPVSGQIEDFLCPVSASGTCVLRETIDNTELVYHALDPVTGIGRELARTPWHPIVLGDWGLSPDGSTLSVTDHDLVHPSIHLVPLGNRNEESPSELPLVGHGALLGSNWAADGRSLFVQCRTRDGFELVNLDMVGHVKVLRKSSVPLWGIPSRDGKKIAFPDRTNSNNVWASDTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2K2</accession>
    <name>E8X2K2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_2182</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580542.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2182"/>
    <dbReference type="EnsemblBacteria" id="ADW69226">
        <property type="protein sequence ID" value="ADW69226"/>
        <property type="gene ID" value="AciX9_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2182"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_0"/>
    <dbReference type="OMA" id="SGCPYCL"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="713"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW69226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="788" mass="86768" checksum="04D1FF5AED5BDE5A" modified="2011-04-05" version="1">MLSLPERVAFLLFALVTGAIGAHGFYRLGRRIGAGRADTDARWDRLPGRAWYALVTTLTQRRTFRKRPWVSSFHSLIFYGFVFYLLVNLVDALEGFFPFTISSGTVAGGAYNLLADVLSALVLVGVVALVLRRFLLPSRRDFSFNERTLLHKDVKEQYVTRDSVIVSVFILFHVGSRAVGAGARIAEDGADRLQPFATLLSHLFTPGDAHVWQVFGYWGALGSVLAFLMYFPRSKHIHIFMAPLKYVVARPVSSGVLPALELNMEAEEPKLGAKRLEDLAWPRLLDAYACIQCNRCQDVCPATATGKALSPSALEINKRMELNELSRNVKGFEQGEASSNPLLGLVLSAEAAWACTTCGACIEVCPVQDEPMLDIIDIRRQQVMIEGEFPAQLQTAFRGMERTQNPWGINHEKRMDWADGLRVRTTDENPTPDVLFWVGCAASYDPQSQKTARAFVQLLDHAGVDFAVLGKRECCTGDTARRAGNEYLYRQLADKNVATLNEVKPKLIVATCPHCMNSVGKEYGQIGGDFKVMHHTEYLETLVASGKLQADMGTATVTYHDPCYLGRHNGVYDAPRNLLNVISNDVVELDRNRENSFCCGAGGAQFWKEEEAGDERISDNRFGEVKRRLEGAEEKVLAVGCPFCKSMLESTPSKGADAIAVKDVAELLLEGVRRRSPVEVAVSALVETSQPVEAMVMSEEVTPDAVAVEEPPAVVEPQAEMPATERAPRKKWVPKGATVDPSVPPKEAEETPVAPVSSDAPKRKTWTPKRAAGSPLEEKKPDDPESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X303</accession>
    <name>E8X303_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579460.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1074"/>
    <dbReference type="EnsemblBacteria" id="ADW68137">
        <property type="protein sequence ID" value="ADW68137"/>
        <property type="gene ID" value="AciX9_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1074"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_3_0"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="165" mass="17848" checksum="53ACD1AF71747703" modified="2011-04-05" version="1">MSEEEVSLCCVYAGERAFGIDTRQVCEVLGRRPVQRVPLAPKFLGGVVPYRGEVLTTVSLRAVLGLEDAEGDGFVMVIDGGVGAKNEDGRFGLMVDEVGGVAMFRVESEVANPATLDARSRAVFDGAFRVDAGLMVRLDVSRLWPVRLRDSGLIWDEEREAGCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X341</accession>
    <name>E8X341_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0303 protein AciX9_2223</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_2223</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0303 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580581.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2223"/>
    <dbReference type="EnsemblBacteria" id="ADW69265">
        <property type="protein sequence ID" value="ADW69265"/>
        <property type="gene ID" value="AciX9_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2223"/>
    <dbReference type="eggNOG" id="COG4702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101036_2_2_0"/>
    <dbReference type="OMA" id="AWIDRKR"/>
    <dbReference type="OrthoDB" id="1742795at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW69265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="161" mass="17440" checksum="942C1546587C8347" modified="2011-04-05" version="1">MGLQDDLDVIAKQEKALQFESFGADTAWEVGCSLREQAMRRAAVMTFEIQVAGRVLFHAVTHNPPAGQADWIRRKRNTVMRFGRASYAMGLQLELEKKTIEERHGLTLADYALHGGGFPIVLRGTGYVGSVVASGLTQREDHAMVVTALGEALGTAVVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3C4</accession>
    <name>E8X3C4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3419</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581737.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70425">
        <property type="protein sequence ID" value="ADW70425"/>
        <property type="gene ID" value="AciX9_3419"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3419"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_2_0_0"/>
    <dbReference type="OMA" id="MGYDTRP"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="63"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="298" mass="32923" checksum="7AA0C34A2822AB9B" modified="2011-04-05" version="1">MHPAAQPTDADLVRGRLALGDFELTLCTDGTYLLDGGAMFGVVPKPLWQKRTPADDQNRILLGLNTTVIRTGQHVVLIETGIGNKQSEKMQSIHQNQAILPLSLAAAGIRPEEITHVINTHLHFDHCGWNTTLHPDGSVTPTFPNARYFAHAGEVAHGHLQLDRDRVSYLSPNYDPLIESGQMTLLTSDQIHLNPTIAPGISVELFPGHTANMLAVHMESAGQHACYIGDLIPTHHHLDPTWVMGYDLDPLTCITERKRFLARAIPEQWLVLFTHDHQVPAAYLNLDEKGKPKATQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3D3</accession>
    <name>E8X3D3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581746.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3428"/>
    <dbReference type="EnsemblBacteria" id="ADW70434">
        <property type="protein sequence ID" value="ADW70434"/>
        <property type="gene ID" value="AciX9_3428"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3428"/>
    <dbReference type="eggNOG" id="ENOG502ZDSB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2977749_0_0_0"/>
    <dbReference type="OMA" id="AIPKPTC"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233621" evidence="2">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="61" mass="6052" checksum="554E3B9AA6337561" modified="2011-04-05" version="1">MKMIVRTLALALLVTGAVASANANTTSSSKSIVSSRTSAMPVPTCPPDDPNGCGIGAFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H0</accession>
    <name>E8X3H0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_1098</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579484.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1098"/>
    <dbReference type="EnsemblBacteria" id="ADW68161">
        <property type="protein sequence ID" value="ADW68161"/>
        <property type="gene ID" value="AciX9_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1098"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_1_0"/>
    <dbReference type="OMA" id="GCIFLTM"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="281" mass="30623" checksum="BE3E1DFD832EE426" modified="2011-04-05" version="1">MKRILTAIVLIAAVVALVFFGPLWSISLFAAVCAGLAAYEYRALAHEKSVYIPLWWIILSIAILFALTLPGVPRELDLPAYALLTFILFTWSGFRAPLNRVLLDTALGLFALVYVAYPLTLLPLIKAHEDGTGLLLFLFVCVWAGDIFALYIGKNFGKRKLAPSLSPNKTWEGSIASVIGSVGCGMALYYLGERLALTRDFTALHITTPAWQMVLLAILLNVAAQLGDLLESAIKRGAGVKDSGTLLPGHGGILDRIDALLLAAPVLWYVLLLKDWQGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3H8</accession>
    <name>E8X3H8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase family 32 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1106</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579492.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1106"/>
    <dbReference type="EnsemblBacteria" id="ADW68169">
        <property type="protein sequence ID" value="ADW68169"/>
        <property type="gene ID" value="AciX9_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1106"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_3_1_0"/>
    <dbReference type="OMA" id="WMGVPDG"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234136" evidence="5">
        <location>
            <begin position="18"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="37"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="376"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="520" mass="57670" checksum="8DE37DCD9291588F" modified="2011-04-05" version="1">MSRLALMLVLAALPAAAQSPATPLGPAYTEPLRPQIHFSPREHWMNDPNGLVYFEGEYHLFFQFNPQGDTPGHISWGHAVSKDLLHWQELPVAIPAIAGDQNELVFTGSVVVDDENSSRLCANNKPCLVAIYTAHHDKSGTETENREAQALAVSQDRGRTWQRFAGNPVLDVGLPEFRDPSVSWSEENHAWLMAVSLPNEHQVAFFTSPNLKQWSRLSTFGPAGITNQHNPKAQWECPDLLHIPADSGKGPGTWALKVGMNPGSPQGGSGEQYFLGNFDGRTFTPSTLPGAHGWTDYGKDSYCAISYNNLPQTEQPTLIGWMDNWQYADKLPTIPWRGQMTLPRRVTWLTDSAGQSLKQDPVVAPLRIGKPTDISRTLKPDQALTLPSLTVPAELTLNIQPNNAQTTGLRLYSDFDHYTEIAYNLTTHQLYTDRTHSLEAATAPPDFLARTEAPTAPTRPYDLHIILDRSSIEVFAQDGTIAMTTLVLPSTTKLRVELFTRGNTQPTQITGKSWQLQPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3I4</accession>
    <name>E8X3I4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_1112</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579498.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1112"/>
    <dbReference type="EnsemblBacteria" id="ADW68175">
        <property type="protein sequence ID" value="ADW68175"/>
        <property type="gene ID" value="AciX9_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1112"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_4_0"/>
    <dbReference type="OMA" id="FWFAACA"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="80"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW68175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="227" mass="24170" checksum="B4B6D47E1807C49C" modified="2011-04-05" version="1">MRNQVEIQTAPAPAASRSRSAAILVGLVVVVTVLIWAGVHNARERRLAMQSLQAQQASRVALIPEAAGKGGAAENPDAPKMQGKVAPGFSLVDLDGKKVSLASFKGKPVLINFWATWCAPCKLEMPWFEEFHQKYASQGLVILGIAADEAGKDVIASTARKLGVTYPVLLKTDEVETAYGGVDYLPESFYVDKTGKVFLETAGMNDDAGGKDEIEANIKKLIAAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3Q5</accession>
    <name>E8X3Q5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_2295</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2295"/>
    <dbReference type="EnsemblBacteria" id="ADW69333">
        <property type="protein sequence ID" value="ADW69333"/>
        <property type="gene ID" value="AciX9_2295"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2295"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_2_0_0"/>
    <dbReference type="OMA" id="VDWNPYP"/>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="PTHR43536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230636" evidence="4">
        <location>
            <begin position="37"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="7">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="242"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="427"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_GlcNase" evidence="8">
        <location>
            <begin position="759"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW69333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="897" mass="98561" checksum="58345E6652B32EF3" modified="2011-04-05" version="1">MPSQYCQLPIATRRISFSKLHALFLCLLLQGMAASAQQPQEISAWEMQDVAKVPATGDAVSLPNFKTASWYKATVPGTVLTTLVDNHVYPEPLYGENMRAIPESLNKTSYWYRTSFTIPSAYKGHTTWLHFAGINYSAQVWVNGHSIGSIKGAFIRGDFDISAAVKPGTKAVLAVLISPQPHPGIPHEHTIADGVGKNGGDTALDGATFLSTIGWDWIPAIRDRDTGIWLPVTLSSTGPLVIDDPAIRSDLAASHATADLSISGAVTNSSAKTVDGTLTGTITEVGDDASPKTITFTRKISVEGGKSLPLALDPAAIPELHINAPRLWWPNGYGKANLYRLSLNLRTSGGTSDVWSGNFGIRTIQYQVAGSENLTLSVNGVPVMARGGNWGLDEAMKRVPKARLDAQFHMHALAHLNIIRNWVGQSTSPDFYEMADKYGILLWDEFFQPNPGDGPNVADIPTYLKNVTDKVTRYRNHPSIAVWCARNEGYPPKELDDTLRVLMAKLDPTRLYQSNSADGHGVSSHGPYYWRSPRYFYALNESFKTETGSVSIPTIESIQGMMPQKDWETINDDWAQHDLAKGAQRGDQYPSLLAKRYGPIRNLADFTRKGQLANYEAFRAMYEGRNAQMFTATTGVITWMSHPAQPSFVWQLYHYDLEPNASLYGAQKASEHIHVQLNEANFGVEVVNNTPEPLSGYQIRSSIYALDGTLSAQQLHPVENAPGVHTTKIFQLVANPSISAVYFVKLDLLDATGNQVSTNFYWQNVDQDDFTSLGRMPPVTLEASATSTLAKDKTMLKVVLHNPTNHVALMTHLQLHREGSEARVLPVFYSENYISLAPQETRELLIDVATADLHGTAPILAVDGFNIHVKSSGGPIRIMNNENADPMHWPASNLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3W2</accession>
    <name>E8X3W2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3465</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3465"/>
    <dbReference type="EnsemblBacteria" id="ADW70470">
        <property type="protein sequence ID" value="ADW70470"/>
        <property type="gene ID" value="AciX9_3465"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3465"/>
    <dbReference type="eggNOG" id="ENOG50305NS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882137_0_0_0"/>
    <dbReference type="OMA" id="AHEDPHY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230651" evidence="2">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="315" mass="33872" checksum="70C581C8768E7696" modified="2011-04-05" version="1">MRWVLLAAVMSPIGMLAQISNGPLPGPGTAVVGAYLPDSPGSIFFEPAAYESASSSTPTFFDPAQAGQISVQTNGQTSERKPRTPTPCVANPNPALTPPPANAKKKDLVPCPQGLNPYERFLNSTQPIPLSPRQKGYLAIHDVIDPFNLLTIGANAAFTVGIDSHSAYGPGLKGFGRNIGYSLSQDVNGEFIGTFLICSLAHEDPHYHRLPQATPMRRLYHAVSRTFVAQKDDGRPMLNIETLLTYPISAELANLYVPGVHGDGVSTVERIATGLATDPVNNIITEFLPDFARHVHIRVVFAQQILNQIASGQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X418</accession>
    <name>E8X418_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">AciX9_3521</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581837.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3521"/>
    <dbReference type="EnsemblBacteria" id="ADW70526">
        <property type="protein sequence ID" value="ADW70526"/>
        <property type="gene ID" value="AciX9_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3521"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650150_0_0_0"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW70526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="422" mass="46371" checksum="85DAA4C2AC4BF01A" modified="2011-04-05" version="1">MRDSGVQPLQPLNQDESLGTEAVAERLRGVALDLFWKKGYKPTTTRDVAAALGIQQPSLYHHFSKKEELLHGICYPTFLHLIETAEAALALAATPLERLRTLARVHLTTTLEFQREFSVSVMECRSLSAEYRAEVDGLWGRYSATIFEVLDGAKGAGVVRGDVANRYLYTALMDMLNWSVLWYRPGAAYTVDELDGIFFSIYLNGAMTASTRAAWKGDSTVREVVAGVAKGPELRLGHARLLDAACALFARSGYFATSMREIAEAAGIQKATVYHYASSKEDLIYQISRAAVEHLHAGVEGALAGRTDPIERVHVLITAHVVCLLEHQSWHASANDELHALTGERKREIVERRDGYEGLLRGVFGEAQEAGLLRGDVPVKLMGLVLLGMVNCIYPWYSAETDLTPVELGALLSDLFLTGCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X440</accession>
    <name>E8X440_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0009</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0009"/>
    <dbReference type="EnsemblBacteria" id="ADW67100">
        <property type="protein sequence ID" value="ADW67100"/>
        <property type="gene ID" value="AciX9_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0009"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432709_0_0_0"/>
    <dbReference type="OMA" id="GWNEAKG"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="189" mass="21548" checksum="912D96017C8D5856" modified="2011-04-05" version="1">MRMSSQAQTPDPTYDAQPSSPPTIRWPGLHQPSDAAIFASNEIVIPAPIEAIWPWLIRAELWPTWYPYSANIHFISTSGPDLRDRTRFRWSKFGVPITSKVREFEPLTRLAYDIHGIGVLAYQAWLLTPLPDGTTHVLTQEVQTGWLARIGKRIMPHRLEDKHQHWLEALSVKAQSGPPAQPRPFLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X481</accession>
    <name>E8X481_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0050"/>
    <dbReference type="EnsemblBacteria" id="ADW67141">
        <property type="protein sequence ID" value="ADW67141"/>
        <property type="gene ID" value="AciX9_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0050"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2665958_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230667" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="75" mass="8228" checksum="ADF31A740649CF0F" modified="2011-04-05" version="1">MRLIFRSLLAAALCLLAVPVISAQTIRVSYPDARSAKPLDGRLLLLLSNDPSEDPRMQINDTQKSQQVFGMTVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4N7</accession>
    <name>E8X4N7_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">AciX9_2410</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580763.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2410"/>
    <dbReference type="EnsemblBacteria" id="ADW69447">
        <property type="protein sequence ID" value="ADW69447"/>
        <property type="gene ID" value="AciX9_2410"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2410"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_5_0"/>
    <dbReference type="OMA" id="NAWAPDA"/>
    <dbReference type="OrthoDB" id="1664448at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="515" mass="53952" checksum="10A663C2BD9203CD" modified="2011-04-05" version="1">MNPNTLALLPEIILTVAGVLIMVAEPCIAPGKSRRGLGWLAIVSAAASAVASVYQLNVTRATLAPIHAFSGTIQVDAFSVFFHLLIAGIVVVSLLGSLDFFDRPDGHAGEYFALVLFGAVGMMFMTSATELLMVFVGLEISSISSYILCGFRKGIATGSESSLKYFLLGSFSTAFFLYGIALAFGATGSTSIAAIAMALSVGTNTPHLAFLALGMIVIGLGFKVSAAPFHVWTPDVYQGAPAPVVGLMSTGPKAAAFAVLIRITFIGFPTIEHRWAALLWILAALSMTIGNLGALMQKNVKRMLAYSSIAHAGYLLAAFTALPSRGISAACFYTATYAAMNVGAFAVVTQLAGYDEHHRTVEDFTGAALRRPWLGALLSFFLLSLIGIPFTGGFFGKFYVFTAVVGGGHTWLAIVGLLNSGLACVYYLRLLAALYTRHPHEKGNDRAVFTKLSLPAALGLAGSALATLALGIIPGRTLDLTNAAAADLLAPNTAPYTSANCPAIQSSNTPDCQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q0</accession>
    <name>E8X4Q0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ordered locus">AciX9_2423</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580776.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2423"/>
    <dbReference type="EnsemblBacteria" id="ADW69460">
        <property type="protein sequence ID" value="ADW69460"/>
        <property type="gene ID" value="AciX9_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2423"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_0"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="630"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="833"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADW69460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1321" mass="145554" checksum="85B7A53008EFB011" modified="2011-04-05" version="1">MLKLKKVQILGFKSFCDRTEVQLAGEGIAAIVGPNGCGKSNISDAITWVLGEQSAKSLRGIKMEDVIFAGTRDRKPTGMAEVSLTLVDPEVYDSADPNAPPDVVYDGKTIPITDWDETTFREELAEETEEAVAEAQPGTTFEAEVKKPRKVEGEASGAEAAPETEAAPETAEAEHSLNNNVVLKIRRRKFGRTPIRAGELTITRRLFRSGDSEYLLNGKICRLRDIQDIFMGTGLGGESYAIIGQERIGQLLSSKPQDRRSIIEEAAGITRFKNKKRLAELRLESAKQNLSRVNDIFEEVTKQMGTLKRQAAKAERYGEIRDDLRTRLRVVLASRIAQLDADQTATTAQIATLTTSIDSQVASTEQMDAEHTEGVRTGYALDQQIREHAATANQSAVELERISARTAANQDRVAELTARLESGAQELEAARAQLAALAGEQEQHRSFLDSANEEAGGSRAAAQAQQQAAQEAVRGVQSKEQQAEANRRATMQLMQRAAQIRNEQSQAEASLSGLERESERLVSESAVAHEELAALGLQRGQVKMSFESVTERLKRLELEISELRLSIEARKSEESQNKRRGDQLRGEVAGLNGRRNSLEGLIRDHSYSTDTVKNIFRTSQKRAQQTGSENTVLGTLADFLEVDGAYEQVVDEFLRDELNYIVVKNWDAADEGIRLLKSDVAGRATFLVHPTSDVHTTTNLGAPRPDSGTWVGAAPIPTGDGVRPLTELVKVLNGFGKSLELTLPKLRDGYVTPDSPTARTLSLQHPHAWFLSPTGETFRNVTVTGGRPSSGGPLALKRELRELQEKLTALEAELSETDLRTATLQHELAADNAQIESKNHERRDAEREAANSGAALRQMESETARIERRLQDWMLATDRNRDARNQKTDLIAARETQATALEAERAALEAGLAEMTDQVEELRAQREELQQAASEAAAALAGLEERRRNAQANYEQTTRLYNGQQQRIGQLDQQLASAATERLRREEETASLASQHEQIAETRLTAVSQGARLTSEAAELRLVTTTLDQKLRALRAETEAFREQRAGHSARLAKLTSDLEHIEQTCLNDLAIPASDLRADESIVRIEGDPLNQLESESRDLKKRLEAMGPVNMMALEEYAEASTRHTFLETQRKDLLDSIENTQASIKEIDDVSRIKFDEAYKIINENFSVTFTKLFGGGQAFMRLTDEGNSAESGIEIVASPPGKKLQSILLLSGGEKALTALSLLVGIFQFQPAPFCILDEVDAPLDETNVGRFARMIADMAQTTQFIAITHNKRTMAQADVIYGVTMQEPGVSKIVSVNLGQNNRSGARERERTSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4Q1</accession>
    <name>E8X4Q1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3535</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3535"/>
    <dbReference type="EnsemblBacteria" id="ADW70540">
        <property type="protein sequence ID" value="ADW70540"/>
        <property type="gene ID" value="AciX9_3535"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3535"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_0"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="286" mass="30501" checksum="9722A2DFFD9544AD" modified="2011-04-05" version="1">MGLPVRTSFEWRLRTRSMPLGKRTVLMGIVNVTPDSFSDGGMLGSVAQVVDHALWLLDEGADLVDVGGESTRPGAIALHTDQEQARVLPVLEAILKARPEAIVSVDTYHAATARRAAEAGAEIINDVSGLMWDPEMAAVMEETQVGVVLMHARGRPQEWAGLPPLADAEILPLVLTGLRESVRAAETAGVRTERIVIDPGFGFGKHGAENFVLHAGLERLGEIALPMLVGTSRKRFLSAEVENRAAGTLASGVAAVLSGAHILRVHEVRAMRAATEVADGILRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W4</accession>
    <name>E8X4W4_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ordered locus">AciX9_3600</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581914.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3600"/>
    <dbReference type="EnsemblBacteria" id="ADW70603">
        <property type="protein sequence ID" value="ADW70603"/>
        <property type="gene ID" value="AciX9_3600"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3600"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_0"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="343"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="493" mass="54291" checksum="E4E0985EBE0566D5" modified="2011-04-05" version="1">MPTLTALSPEILAKYQPVIGLEVHVQLLTESKAFCGCVNKYGGEPNTHTCPTCLGLPGALPVLNRKAVEFAVLAAKAIHCEIRETSIFARKNYFYPDNPKGYQISQFDKPIAEGGWLEVPTAEGGTKRIGVTRLHMEEDAGKSVHDGFMDSVNRTYIDLNRCGTPLVEIVSEPDLRTADEVFEYLTKLKEILLYTGVSDCNMEEGSLRCDANVSVMLKGAKEYGTKAEVKNVNSFRYIRSAVEYEIERQIGVIEDGGRVVQESRLWNQGEGRTYSMRSKEQAHDYRYFPEPDLPPLVVGAEWQAEILKDLPELPEARRARMEAEYGITPQDAMTFTATRAFADQFEAAAKKAKSPRRVAALLTSEITMRVRAAGIEMEASPVSMDGLVLAADLAESGELSSKMLKQLLDTAFANGEDFLAVYEREKPQQISDTGAIEAMIDEVIAANPKQVEQYKGGKKTVAAFFVGQVMKASKGQANPAVLNQLVAAKLDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8X512</accession>
    <name>E8X512_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_0127</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="10">Binds 1 FMN per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013578532.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0127"/>
    <dbReference type="EnsemblBacteria" id="ADW67204">
        <property type="protein sequence ID" value="ADW67204"/>
        <property type="gene ID" value="AciX9_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0127"/>
    <dbReference type="eggNOG" id="COG0369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_7_0"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="707164at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010199">
        <property type="entry name" value="CysJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000207">
        <property type="entry name" value="SiR-FP_CysJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="11">
        <location>
            <begin position="43"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="500"/>
            <end position="501"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="506"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000207-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW67204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="577" mass="62691" checksum="BC1FC7FEF0E936AD" modified="2011-04-05" version="1">MSSVPFIPDSAPFNPAQRAWLNGFLAGLYSSAPQSAVFEPRNVAVLYASQSGTGERLAKKVAKELKAKGHTAKLSSLDVYPVHELAVEECAVIVASTYGEGDPPDGVKGFFDSLCAEGAPRLERLEYSVLALGDSHYEHFCKFGVDLDERLQDLGAKRSIPIVTADVDVDEPFERWKAALLASLDTAAAATPPQALAAAAPVAPASLYRRENPFQAALIEKRVLTADVSSKSTLHLSFSLAGSELTYEAGDALAVIPANDPALVADVLSATGLNGEELVEVPKLGTRSLCDALTHVLQITKLSRKLIDAYAKAGNIALLIDLLLPEQQTHLDTYLYDRGVIDLLAEHPGAIASAQQLADLLPKLAPRLYSISSSPKAHAGEVHATVAVVRYRAHNRERGGVCSTLFADRTDLNGTLPVYIQHNKKFRLPMDPDAPIIMIGPGTGIAPFRGFLHERLAMGATGRNWLFFGDRSAATDFLYREELEQMLGTGHLSRLDTAFSRDQAHKIYVQDRMLEHGAEFFAWLQQGATIYVCGDASRMAKDVDAALHQLIAQHGNTDAEAYVQDLHDSKRYHRDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X530</accession>
    <name>E8X530_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC domain protein dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_0147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW67222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_0147"/>
    <dbReference type="EnsemblBacteria" id="ADW67222">
        <property type="protein sequence ID" value="ADW67222"/>
        <property type="gene ID" value="AciX9_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_0147"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564885_0_0_0"/>
    <dbReference type="OMA" id="EMRIDER"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW67222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="495" mass="54162" checksum="0BDC536BF36FAA60" modified="2011-04-05" version="1">MIEGIEMRIDERIVGDEGQERFAAATGDRNPIHMDAVQARRTQAGLPVVHGMHTLLWALETLTTEDHIVRCPTRIKVKFLKWVYLGDMAEIILVSSVESILRFRVEVAGMSTLSAEIHFGASSADQQIELEDIHSRSAQTPLEAPRNLDLAELEKISGNAFVATKQDMRQMFPDLCDLVEARTVAELAACSYVVGMEAPGLYSTFSKLDLEIGLTPTGGAGESLSFNVARVDERFRKAQIHVIGSNIDGFLDTFVRTPPVEQATMPELASRVRPEEFADMRALIIGGSRGLGELTAKLIGAGGGSSTITYTLGKLEAGKVIDQIRSAGKQIEMLPYDVRKPAASQLSLLNGPITHLFYFATNAIFRPKGEVMSSSILADFSVFYIQGFYDLCKELVGSEKTYVSAKAPLAVYYPSSIAVEERPAGMTEYSMIKAAGEILCDDMNQHMPGLHIITTRLPRLRTDQTAGVLPEREQDPVDILLPILRKLSSSAGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X541</accession>
    <name>E8X541_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_1242</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579628.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1242"/>
    <dbReference type="EnsemblBacteria" id="ADW68305">
        <property type="protein sequence ID" value="ADW68305"/>
        <property type="gene ID" value="AciX9_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1242"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_233755_0_0_0"/>
    <dbReference type="OMA" id="ATDNTNF"/>
    <dbReference type="OrthoDB" id="854119at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234386" evidence="2">
        <location>
            <begin position="21"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="1371"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="1907"/>
            <end position="2000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW68305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="2009" mass="200602" checksum="BBC43A235D8614F6" modified="2011-04-05" version="1">MRPARLSVLFSLALSTLLYGCSSPVAPFTNPSQPAVTITGKVQAGQQAVSGATIQLYTVGTTADGSAATPLLTSTVTTDASGNFALSGLYSCSQATQVYVTAVGGNPGLSAANPNLAEMTAIGPCSSLTPNTLIFVNELTTIAATSALAPYATSAPAIGSSSADSTALASAFTLAGELVNTVTGTTPGTAVPAGSTVPISLIDTLGNIISGCTHSAGGATSGSTCTAILNLTTPPNSKAPSDTLQALFNIANNPTLNIGPLFALDPPTAPFQPQLASAPADFAIKLMPLISSSTLTITPSSLAFSATTLGSVGPAATVSITNPGTTAVALSSVAIAGVNSADFTQTNTCGTSIAGGATCQALVTFAPAATGTRNASLVFTSSATGSPQTVALTGTGAAATVGPIAFSLPSLSYNVDDSIQDVNLQNLGNVPLTISSIATDNTNFEVESSNCGTTLAAQSVCTISVRTLGFLWSGSTTLYSTYTGNLIVNSNASAGPQTLPLSSTNTLYLPAIPADFGASPVGITQTSGTITASPGSYYESASLSTSIGGANASDFAVSPASCNVPVSSVTNCSLAISFTPSASGTRSAMLYVATGNDSPNSATNKQYLRLSGIGNTTGPSFAVTYKSSTQTRGYAILNTAGTASNTDTYTVLNTGSTIISLSAALTGSAAADYTSTNNCVSISPSSSCTLNVVFTGSSVGTFPATLTLTDTVSTSSQPLQLSTLVQYPTPVPSPYSTDFGTQPLNIAATRNVFITSGTYGSTLEEPVTASITTGSGVFSLPGGSTCPASTSQTCTLTVAFTPTAVGNFTGTLTLTGQTSGNQANYPLSGGGGVATLALSPASLTFPVRTVGTTSTPMNVTVSSTAALSLNISSITITGVNSNDFTQTNNCTAVTVSSTCTIAVTFTPTAIGTSNANLVLTSNATGSPQTVPLTGTSAAATVGPIAYSLASLSYTVDGSIQDVNLQNLGSAPLTISSIATDNTNFKVESNTCGTMLAAQSVCTISVSTGGFNIINQQYSTYTGNLVVSDNATAGPQTLPLSSTNTISISTVPTDFGAWPINTTRTGGIITANTGSYYTSDALLAAVGGTNASDFAVSPSGCSIQANTSPSNCSLAISFTPSATGTRSAKLYVSNASGTPNSQYFRLSGTGDATGPSFVLTYKSSTGSPVLNTSGTAFYTNTYTVLNNGTTTLTLSGIVSGPAAANYSSNSNCSSIAPNNSCTLNVTFNGASHATYLATLTLSDSFSSYSQPLQLSTVVQYPTPILSPNSLTFSAQPLNTTTTQSLTISSGTYGSTLEEPVTAALDTSSIYSNAFSLPAGSTCPASTSQTCTLTVAFTPTAAANGVNGSVIFTGQISGNKAYLALYGIAGSPALSLSPTSLTFPARALGTTSVPMNVTVSNTGTLPLNISSITVTGANISDFTQTNNCSTVAVGSTCTVAVSFTPGATGSGNASLVLTSNAPGSPQTVALTGTGAAATVGPVTFNFSSLSYTVGNSIRDVKLQNLGSTPLTITGIATDNTNFKVESNTCGTTLLAQSLCTISVQTLGFGFSGITLNYTSYTGNLVVTDNATSGPQTLPLTSTNTVEVGATADFGAWPVETTHTGVISSSSGTYYQSSAVSFVLGGINASDFGPSGGGCYTTALQNSSCSENLSFTPSATGVRSAVLYVNSSNLSADASQYFRISGTGDPVGPSFIATYKSSTQSRGRVVLTTAGSATNTDTYTILNNGSTTLTLSGMASGSAAANYSSTSNCASIAAGSSCAFSVTFTGTSIGTFPATLTISDSLSSYSQSLPVSTTVVYPTPTPSSSSLNFNAQPLNSTTTMSATISSGTYGSTLEEPVTATFMSNSSSFFSLTNGSTCPAGTSQVCTLTVAFTPTAVGYVSGAIILTGQTSGNQGYLNLYGIGGLPALSLSPTSLTFPARSVGTTSVPMNVTVSNTGNQPLNINSINVIGATNNNFTQTNNCTQVAAGSACTIGVTFAPTASGSQAASIRIISNASTSPDTITLSGSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5D5</accession>
    <name>E8X5D5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_2447</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580798.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2447"/>
    <dbReference type="EnsemblBacteria" id="ADW69482">
        <property type="protein sequence ID" value="ADW69482"/>
        <property type="gene ID" value="AciX9_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2447"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377112_0_0_0"/>
    <dbReference type="OMA" id="GWPARAV"/>
    <dbReference type="OrthoDB" id="1052907at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW69482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="740" mass="79682" checksum="939D39BDF16F66E5" modified="2011-04-05" version="1">MTPLDLQAIYNMIPAVYRIRDAEIALQSDATLDAADAAELAGLLTQTMLSAAEQGRLAELQALQQRGPLQSMVALLAEQIEVLQESLYQGYDDLFIETCAEWLVPYIGELVGFPALADFPGTPYSLRAAVAEAIRTRRRRGTVSGLESVARDISGWPAHVVEYFLELATTQYMNHLRPANHSWVDVRNASDRLPGTPFDNSARTADVRRIATGGGLYNIPNIGVWLWRLTPYSMALAPACRVDNRRFLFDPLGRDTQLYTESAPVSQTTDRATSFNVPLPITRRMLWRNFKDIRRNRPIQGTFYGGQEENSLSIDQSQLGTPSPDWPVIECDLRDVYDGMGNVTGWAHAPTNVIAIDPELGRFALPADAPAGELLTTYSWAFSADIGGGPYSRPFVGDENSTATIKVPSDAATLTDALAKATTEFAGDTSAVTILIQTSARFVETPSISIPEKCSLTIQAADGYRPTLVLSDDMPVIGGDGSSLTLNGLLIGGGCIAVPATDGGSLNLLAKLTISHCTLAPGAIRAIEGAPAQPAGPRLYVEAEDVQLALDHTITGALRLRESGDLTAISCIIDAGAATEIAYANEDCSASGAAMTMTNCTVIGLLQTRQIVLASNCIFDALIQEGSLFPFPVNADQLQQGCTRFCYVPPGSRVPRPYRCYPGSGTGKAHVPAFTSRRQGDAGYCQLAFSTGTEIMQGADDGSEMGVFHDLHQPQRLSNLQLMLQDNLRFGLEAGIFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5G0</accession>
    <name>E8X5G0_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="10" type="ordered locus">AciX9_2474</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580823.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2474"/>
    <dbReference type="EnsemblBacteria" id="ADW69507">
        <property type="protein sequence ID" value="ADW69507"/>
        <property type="gene ID" value="AciX9_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2474"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_2_1_0"/>
    <dbReference type="OMA" id="LYRMRMY"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="9">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="8">
        <location>
            <begin position="134"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW69507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="191" mass="21102" checksum="D18D9298C910F3D4" modified="2011-04-05" version="1">MAALLEAINIKRKFMFEYENAPYACLDSDISSPTARGGQTLVRLKMRNLLTNAVFEKTFKAGDKFKEPDLVLVPASYLYSDGEGSHFLDQESFETLTLNKDMMGNALDFLIEGAMLQLHKYNGNPIGLQLPIFVELDIAHTEPAVRGDSSSGSVTKFAKLETGLEIKVPLFIKEGEKVKVTTETGEFSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5U8</accession>
    <name>E8X5U8_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ordered locus">AciX9_4037</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="12 13">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
            <plasmid evidence="13">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572744.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70832">
        <property type="protein sequence ID" value="ADW70832"/>
        <property type="gene ID" value="AciX9_4037"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4037"/>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_0"/>
    <dbReference type="OMA" id="MILAGNC"/>
    <dbReference type="OrthoDB" id="49441at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-0614">Plasmid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="146"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-112)" evidence="8">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="745" mass="82528" checksum="77BA956828DE189D" modified="2011-04-05" version="1">MSNEMKCPVPHGNNPSITSTETESPMHGAVTHNSRKIQRNEHWWPDRLDLAVLHQNNKLADPTGADFEYAKEFKTLDLDAVIKDLHVLMTDSQSWWPADYGHYGPFFIRMAWHSAGTYRTYDGRGGAGMGTQRFAPLNSWPDNVSLDKARRLLWPIKQKYGKKISWADLMILTGNVALESMGFKTFGYAGGRADVWVPQEDIFWGTEHTWLGSDRYQGDRELDKPLAAVQMGLIYVNPEGPDGKPDPVGSARDIRETFGRMAMNDEETFALISGGHTFGKAHGAHDPGPNVGPEPEGAPIEQQGLGWKNSVGKGNAEDTISSGLEGAWTSSPIKWDSEYLDNLYNYDWALKKGPGGAWQWYAVSEPANIPDAHIADKKHLPMMFTSDMALKFDPEYEKIGKRFQANPDQFADAFARAWFKLTHRDMGPIERYLGPLVPKERLIWQDPVPAVDHELIGEAEIAALKKILISGFSISQLVSTAWAAASSFRGSDKRGGANGARIRLEPQKNWEVNQPVVLAKVLATLEEVQKAFAESTSKKVSIADLIVLGGSAAVEEAAKKAGYDVTVPFAPGRTDASQEQTDVEAFEPLEQTADGFRNYLRLGHKLRAEELFIDRAQLLTLTAPEMTVLTGGLRVLGANYKQSKDGVLTNTPGTLTNDFFVNLLDMATEWKASTTAEGHFDGLDRATGEVKWTSTRVDLVFGANSQLRAIAEVYAASDAKEIFVKDFVAAWTKVMNLDRYDLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8X5W1</accession>
    <name>E8X5W1_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">AciX9_4056</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MP5ACTX9</strain>
            <plasmid evidence="10">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572757.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70845">
        <property type="protein sequence ID" value="ADW70845"/>
        <property type="gene ID" value="AciX9_4056"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4056"/>
    <dbReference type="HOGENOM" id="CLU_637374_0_0_0"/>
    <dbReference type="OMA" id="FTARWTF"/>
    <dbReference type="OrthoDB" id="541005at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADW70845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="434" mass="46817" checksum="BBB724485AF3F2B5" modified="2011-04-05" version="1">MGTSQTAPAQNVAFRGVTSLHVMGVLCGLAAGVWLGAAEAPTKLVNAGFSPFAISLCMVAGVFTARWTFPTLLKGTTYVFADLMAKKHLIVWAILAGGLWAVANTLTVFAIRDVGLATAFPLWNTNSLIGLLWGRVLFRELEGAGFRNTIKVVFGAVLIVVSAIMLGFSTIHGSGVRAPHAVHGLIAAAGASLMWGTMYVPYRKAYLSGMNPLSFVTAFTVGELGMMFALTWTLDGGAHSSVFQLVHSQHLLFWLFLGGFVWVVGDLFQQFAAKYLGIGRGIPLSNTNQLWGLAWGALVFGELATADRAHKILVISGSVIMILGALAISTAVASSREHLSNNAALERECDRYGLDYWEVLSAQSGDEFGARDERRRWWDVMIVLAAVGVFIWLGSRAIVPPIFIDIRWLAVLTAVLVLALLGGGWALWRNTRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8X602</accession>
    <name>E8X602_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4106</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW70886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572798.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW70886">
        <property type="protein sequence ID" value="ADW70886"/>
        <property type="gene ID" value="AciX9_4106"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4106"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_0"/>
    <dbReference type="OMA" id="PHVLTHM"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW70886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="210" mass="22745" checksum="D8592E74B7091145" modified="2011-04-05" version="1">MNSSQSIRVLTVDDHPLLREGISGVVNAQPGMTVVAEASDGDEAILSFRTHLPDITLMDLRLPKTSGIEAIVTIRKEFPAARIIVLTTYAGDVQALRAFKSGASGYLLKSMLRAELIDTIRRVHAGQRRIPPEIAAEMAEHAGDDILSAREIEVLRHVAAGNSNKIIASNLTLSEHTVKGHIKNILSKLGASDRTHAVMIALRRGFLDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6C3</accession>
    <name>E8X6C3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572919.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71007">
        <property type="protein sequence ID" value="ADW71007"/>
        <property type="gene ID" value="AciX9_4230"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4230"/>
    <dbReference type="HOGENOM" id="CLU_039329_5_0_0"/>
    <dbReference type="OMA" id="TTNYKAI"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="42"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="322" mass="35142" checksum="E19DF3C9B0A53321" modified="2011-04-05" version="1">MRTITLEEHFVTDSFLRATGAYDKPAPPWLAQLQPKLLDLGDGRIAAMDEAGIDLQVLSLAALGFDALDAATATPLVHDINDELAAAVRANPTRLAAFASLALKDPQSAARELERAIQKLGFRGVLLDGTTDGLFLDDPRFTPVFEAAVALNVPIYLHPAPPPESVFDTYFTGLPEGVGQMLSIAGWGWHAETALHTLRLITNGVFDRYPTLQLIIGHMGEMLPMALARTSKALSHAARLRQPVAAYFQSNIHLTTSGYFTQPPLRCALDVVGIDRLMFSIDYPFSANTLGRDYLTELEQTLTPEDLAKLIHRNAESLLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6D6</accession>
    <name>E8X6D6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572932.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71020">
        <property type="protein sequence ID" value="ADW71020"/>
        <property type="gene ID" value="AciX9_4244"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4244"/>
    <dbReference type="HOGENOM" id="CLU_008033_1_0_0"/>
    <dbReference type="OMA" id="LYNFRAN"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234440" evidence="1">
        <location>
            <begin position="24"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="800" mass="88737" checksum="334B535A36B4490C" modified="2011-04-05" version="1">MRTLSLQVLLLCSFVQTLPSAFCAPAPHKVQLKAVPLPLNSVRLTGGPLKKAQDLDAQYLLELQPERMLAFLRQRAGLEAKAQGYGGWDGPGRQLTGHIAGHYLSAISMMYATTGDVRFKERADEFVAELQTIQNAQGDGYIGALLDAKGVDGKVKFQDLSKGEIKSGGFDLDGLWSPWYVEHKLFAGLRDAYHLTGDRTALEVEIEFAGWVEGILKNLNEDQIQRMLATEFGGMNEVLADLYADTNDTRWMKLSDKFEHHAIVDPLSQGQDILAGKHANTNIPKMIGELARYEYTGDEKDGKAANFFFDEVSLHHSFATGGDGKNEYFGQPDKMNDMIDGRTAESCAAYNMIKMARTLFSLDPQARYADFVERADLNAILGGQDPDDGRVSYMVPVGRGVQHEYQNKFESFTCCVGSQMETHAFHAYGIYNESGNKLWVSQYDPTTVDWASQGVKLEMVTDLPMGDTATLKMTSGQSKVFTLALRRPYWATSGFAVKVNGVLLKNVSGPDTYIEINRRWKVGDAVEVVLPKTLRKEPLPDNPNRMAIMWGPLVLAGDLGPEVSRRRNGGEGSASAVPEAAPALITAEHNVNGWLKPVAGKPGIFRTANLEQKQEVEFEPFYEMPRRRYAIYWDVFTPNDWAKKSADYEAEAVSDKKLTAATIGFAQPGQMQTERDFGEKDEDSTPVQLQGRYGRQGTAWFSYDLPVDSASPVILVVTYSNDAKGRKGSFDILVDGTKVGEQAIERRTPELDIRFFDVKYSLPLDLVKGKQKVTVRFQAKDGDTIPGVFGIRTVRTDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6E6</accession>
    <name>E8X6E6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4254</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572942.1">
        <property type="nucleotide sequence ID" value="NC_015057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71030">
        <property type="protein sequence ID" value="ADW71030"/>
        <property type="gene ID" value="AciX9_4254"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4254"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_0"/>
    <dbReference type="OMA" id="TIYTPFR"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233738" evidence="3">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AMP_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="471" mass="52904" checksum="96E017375AB1715D" modified="2011-04-05" version="1">MTTRLTTLLTLLFLALAFDAAAQPVRNSFPPEEFAARRAHVFEKIGDGIAILEGTTERPGEQPFRQGNQFYYLTGVSEARAIALLDGRTKETTIFLLPLKALDVDSKYGPGALYPGDDSARTSGVTRVLPREELTAMLAPIAREGRTIYTPFRPEVLGSASSYDTLLLTRLNHDDPWDGRFGREEAFRLKLMTASPKSEIRDLDPIVDELRAIKSEREIAVLREATRIADRGILRAMHAAKPGLYEYQLQAESEYEFKRDGAYGPAYFALVATGKNTWYTHYHYDTAQLAPGDLIQYDYAPDYRNYTSDVTRIFPASGKFTAHQREYYVIYLRLYQAIMGSIQVHESPVTVTQRAVAKMDAIVAAYTFTDPAIKKAVLEFVDTFRGKKGGFLGHAVGMEVHDVYGSYRTLEPGMVFTIEPMLRLPEEHVAVRLEDMLLITPSGYENLSRSVPIEVTDIEKFMAAPLPKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G0</accession>
    <name>E8X6G0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, CadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_4271</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71044">
        <property type="protein sequence ID" value="ADW71044"/>
        <property type="gene ID" value="AciX9_4271"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4271"/>
    <dbReference type="HOGENOM" id="CLU_397747_0_0_0"/>
    <dbReference type="OMA" id="HEMALDF"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="680" mass="73581" checksum="2AC63238BEC2B9D8" modified="2011-04-05" version="1">MQSMLRPSASDGTVSASLPQGPSGVFVYVFADFRLEPENRLLTCAGKEVPLPGRAFDALLMLVRRPGSLLSKEELMASVWAGSFVEESNLTVTISTLRRALNEDPHDRRYIQTVARRGYRFIATVTELPQTVASMPRTFIKENPAETPVSDRLFVEPAEEDVAAGPPIYTGPQPLPGVTPFLRRLRHGAIATVWVGLLAALVLGGWLLLKPNQPLRTLAVLPFSSDSSSTGSAPNGFILLGMTDSITSRLEANLVVRPTSSVLRYSTTAPVSPVVAGREQEVDAVLTGQVNESGGSTQLRLHLIRVSDGLTLWQDSFRAASSDLKGLEQEAGDAASHELGPAGKAGGGPARPAPAANAERSRVDEPAYQLYLRGRFFWNRRTVEGLRKSTEYFRQAIDADPNYAAAYAGLADSYALLASFSVEPGRAANADARSAALSAIQLDPTLAEPHASLGMIYFFTDWNLPAAEVEFGRAIRLNPNYATAHHWYALDLAAMGRFPQALYEIRVAQKLDPLSLIIGTNVGWIEYLAHDYADALHDLHRVLELDPNFVRARTRLGMVEMATGDNSAAEADLKQALVLSGDEDPWVEGLLGDAQARAGNRTAAEHALAKVSVQGSSHYVPPTSRALILLGLGRRAEAVAALSQAIEDHSTSMVYARVDPSLDTLRSDPPFQALMTRMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6G3</accession>
    <name>E8X6G3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4276</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX901</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid1 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX901</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002481">
        <property type="protein sequence ID" value="ADW71047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71047">
        <property type="protein sequence ID" value="ADW71047"/>
        <property type="gene ID" value="AciX9_4276"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4276"/>
    <dbReference type="HOGENOM" id="CLU_3062063_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX901"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="53" mass="6086" checksum="51BB9C3B20A22011" modified="2011-04-05" version="1">MLLDNPVNEMVRRLISTQKVGDCVGRFKEDYRHADSPGNQAIRSLPYAKILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6L6</accession>
    <name>E8X6L6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">AciX9_3886</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MP5ACTX9</strain>
            <plasmid evidence="9">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E8X6L6"/>
    <dbReference type="EnsemblBacteria" id="ADW71166">
        <property type="protein sequence ID" value="ADW71166"/>
        <property type="gene ID" value="AciX9_3886"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3886"/>
    <dbReference type="HOGENOM" id="CLU_002926_3_0_0"/>
    <dbReference type="OMA" id="AIGDWMY"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="347"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="533"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="639"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="973"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADW71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117795" checksum="057201408C31DFC8" modified="2011-04-05" version="1">MKAIRLKVNYRLWALSMQILLLISGAARVSALPVGLRVDSRVNPLGVDTAIPSLSWRSDDTQKNWTQSAFRIEVASNLSLLKANMPDVWDSGRVASNESVAIPYKGPTLMATKRYYWRVRTWDRAGKEQTSAELAWWEMGLIGNNSWKAKWIGYSDNTDAQALQRVRWLWLPGGDAHHVSGGQPVEFHYVLHLDAQPAAAVLHCLTGGTFTTLVNGNQTGHKQEWTAFDREDLRNQLHAGPGISGDNDIIVRTIAHEARTPDTTANGFAAVLDLRDEHGHNRQIVTDAAWTARPSSEASWQPAQVVGPLNDLQVNVGSDRRKIVPAPERISTGVSLLRTDFAVDGPIRSARLYITAMGSYRAFLNGKRIGETVLTPGFTDFRKRALYQTYDVTQLAKSGSNAFGVKLGGGWHGSPLLWSGVREFTGPDLLRAQIIVTLQDGTQKIIATDSSWKGSRSATDSAEIYGGESYDARLSETGWNTVQSASKLAWAPVKEGSVSNDTQISAQPDSSPHVSQTLKPVSVHLVDAAGVPAGTKLFDMGQNMVGVVRLRVHGVRGSTVRLRFAERLKPDGSVYTENLRNADATDEYTLRGGGLEEWTPMFTFHGFRYVQAEGLPAGAGRDSLLGEVENSLPDEPSTRFTSSSPLLNSMFELGLWGQRGNFVSIPTDCPQRDERLGWMGDAGVFWQTGSYNFDINAFTHKFMDDVTDGQDARGIFSNVSPNLLQVGPEVVGAPGWGDAGVLVPYATWMQYGDRSVIDKNWDAMERWIRFIEESNTAGLRSNDLGPNYADWLAPDPNTPKDLVATAYWALMTQQMKSMAIATGRAEAAKRYEQLYGKIRKAYRKAYVHEDGSVEGETQTAYVLTLYTGMDEKEESGVITGRLIADIEKHDNHLTTGFLGTPFLLSVLDTQNRSDVAYRLLLNKTYPSWGYMVKKGATTWWERWNGDTGDPGMNSYNHYAFGSVMAWVYRRVSGIDTDASGPGFHHMIIAPQVDPLLRHVRMEYTSVYGKVVTDLTRSADGGLKLSVSLPANTSATVQLPQGDHGTIKQDGALISSKKIEIGSGEAIFTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6R7</accession>
    <name>E8X6R7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3941</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582235.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71217">
        <property type="protein sequence ID" value="ADW71217"/>
        <property type="gene ID" value="AciX9_3941"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3941"/>
    <dbReference type="HOGENOM" id="CLU_006298_0_0_0"/>
    <dbReference type="OMA" id="NGIRNSM"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="1165" mass="124707" checksum="A3D0230CADDCC6FF" modified="2011-04-05" version="1">MQRLRTFRNYLASFLFLIALTLGLSTQAWSQAATGGGLRGTVVDPSGAAIPGAKLILKSSGTGAVRDLSSTSTGLFSFRDIDPGKYTMVVTAPGFQETRFAEVTFVLGEIRELNVTLALGGANEVVEVSTDTASVVSQETTVGTLIDGTQIRELPLNGRDFQNLVLLAPGSSRTASGTGQGSGVSAGGSRPTNNNYLLDGGDANDPRVPSGSAGNVGNATSAVPLDAIAEFSVITSNATAEFGRSSGGIINVVTKSGTNQVHVAVWEYLRNSVLNTRNFFNPVGFKSPFKQNQFGLWFGAPIWHDHTFISASYEGFRQRSTTAALVPVPTAQFTAALTNPLAQALFTSSYPSVVGATPFSATDPTTWSTTVNRNLVNNLDQDTGFVRLDQQLTQRNNIFATYSLVAATPLATVGSSNLAGFGYGNVLRPSHLVVQDNHIFSPNLLNTARFSFQRTATLYPLQAPSAALAAAGTFRTAGPNAGQAYSANGGDPNGFPSLAFNSGRFNAIGIASNMPQSRIPVVWTYQDALSYSRGKHEFKGGAQLSRVWDNTTFSNAIRPNIAILDTSFANINSLTLSSQSQSFYIAPSFRQYRIWEQGYFVQDSYRATKRLTVDVGLRYEIFNPFTEKNNLLSNAYVLDSSGKPAACQNLPFNPSESNVADINPSSYGIGNYCSHFGNFSPRVGFAMDVFGTGKTVVRGGYGYFYDRVFGNVYGNARFNPPQTLSTTLSTGNYTGATAASTVNTTQSYTLTNIDPSLRNPVTQHYNIAISQQVDKSTAVTVSYVGALAQHLLTTTRPNFGTSFNDSFRPSNQGTVVRTIADINNSIIRPPFGALTYHQSNGTSNYNALLINVKRQMRAGLSLEASYGLTHSMDVLSDDVAGATDSATPAATLNNLLAPYMVVNAATPAGPCKTAQATTASSAAVLTAAVQCAENNPTLTQAQAQAIFLSKYVTYANLKTNYGDSSFDVRQRFAASLNYHLPFGKNQMFLTDGGAFTDHLISGWGIASIFDTQTGVPFIPTTGADSNRDGDTTDRAVLTGAVPNRKGILTKSFATSSPTVSYFNLSTASGGFVAGDGVVDPTQRIHRGYLRNPGIFNWDFQANKQTKVTERVDLRFTADFFNVLNHTNFSNLTAGITSKQFGQSLSTRALGQTQSRQIQFGLKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6U9</accession>
    <name>E8X6U9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">AciX9_3975</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MP5ACTX9</strain>
            <plasmid evidence="5">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582267.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71249">
        <property type="protein sequence ID" value="ADW71249"/>
        <property type="gene ID" value="AciX9_3975"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3975"/>
    <dbReference type="HOGENOM" id="CLU_031875_0_0_0"/>
    <dbReference type="OMA" id="IHWSIWL"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADW71249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="409" mass="46488" checksum="8D4004020CCCE659" modified="2011-04-05" version="1">MLVGRMVAGLVLSLGLAAGSMQGQFVHTHKTEVLDGQSKPLLIRGTNLGDWFVPEGYMWHLPDTVQSPREIEGLVRELIGPTKATEFWHEYRQRYVMRADIHLLKQAGFNTVRVPFHYKFFETDDAEGFALVDRLLGWCRAEGLYVILDMHVAPGYQTGKNIDDSDGYPWLLKDEGEQAHAVAVWERIARHYKDDKTVIGYDLLNEPIPNYPKLKPLNELLEPLYKKLTVAIRRIDTKHMMIYGGAQWDGDFSVFGAPFDANALYTWHRYKAEPTEAAFKQYAAFRQRYQVPIYLGESGENTDAWIASFRAANEKANIGWTFWPYKKMSATTSPVSFAKPDGWDEVLAFAALQRGSVLAPERLKVRPEQGVLDRAFSSMLENIKAERCTVNEGYIHALLPDAPAELKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6V7</accession>
    <name>E8X6V7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly(Beta-D-mannuronate) lyase</fullName>
            <ecNumber evidence="3">4.2.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3983</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013582275.1">
        <property type="nucleotide sequence ID" value="NC_015065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71257">
        <property type="protein sequence ID" value="ADW71257"/>
        <property type="gene ID" value="AciX9_3983"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3983"/>
    <dbReference type="HOGENOM" id="CLU_064286_0_0_0"/>
    <dbReference type="OMA" id="AAWSVMA"/>
    <dbReference type="OrthoDB" id="804604at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045135">
        <property type="term" value="F:poly(beta-D-mannuronate) lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233752" evidence="1">
        <location>
            <begin position="29"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="356" mass="37992" checksum="F1695BE140D1EC0F" modified="2011-04-05" version="1">MQRSFVPSFRSIGVSVVLACAAFASAGAATLRSPWDGHAVTLTDAPYSCPALPAVAPDLTTDGFYRTDDPTHSIVDPVRMEAYKRSSDPVKEVGQTLVREADAFRTTGSRAAGRCALEQITSLARQRSLTGKMSSNQAYYVQGWIAGAIAIAYLKISDAGLATPEQRRLIAPWLLQIGDATRTWYDDHAAKTHVSAGNNHLYWAGVELAAIGVAANDRKAFDWGMATYENGVAQIRPDGTLPLEMERGTKALHYHLYALAPLVLLAELGEVNGLDLYAAHGGAIHRLVKVSIGGLSDPAVFVAGTGKQQEAPGTVSGDQIGWAPPYERRFPDAAIARYVKAAPSLSVFYLGGLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6X6</accession>
    <name>E8X6X6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71085">
        <property type="protein sequence ID" value="ADW71085"/>
        <property type="gene ID" value="AciX9_3799"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3799"/>
    <dbReference type="HOGENOM" id="CLU_073042_1_0_0"/>
    <dbReference type="OMA" id="AEFKWGE"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234465" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="40"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="253" mass="28191" checksum="3F56E92161880C85" modified="2011-04-05" version="1">MTLIQLTKRVLVTIGAGSCLWASAQTMPDTAIPPHKSAVILFNGKDLSQFDTFIRGRGLNNDPAHVFQIENGIIHVSGQEMGYIITRESFHRFYLRAEFKWGEGTFGERAGQARDSGILYNIQNEQKVWPRSLEFQIKEGETGDFWLTDGAALTGSDGKRVTGPPGSALNIGHLDKGPQKNVVGFRNTTGEFEKPHGEWNTLEVIVDDKVIRQYVNGKLANTGTDPFPTDGKILFQSEGAEIYFRNMQLYPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X735</accession>
    <name>E8X735_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013572988.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71269">
        <property type="protein sequence ID" value="ADW71269"/>
        <property type="gene ID" value="AciX9_4310"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4310"/>
    <dbReference type="HOGENOM" id="CLU_127147_1_0_0"/>
    <dbReference type="OMA" id="MIPAGDM"/>
    <dbReference type="OrthoDB" id="1900882at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="126" mass="13048" checksum="F150ECC4DB8F6A61" modified="2011-04-05" version="1">MHNAIPLALAILVSVGIIVIGCLYVGSPERILGGFGLKPPAADSDTRAWLRLKGIRDIASGVAVLTLMLTTDSRTVGIILLVLAIIPFGDMSNVLSSGGRKGTAFSVHGLTCAVMLFAGLLLIHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8X766</accession>
    <name>E8X766_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_4348</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
            <plasmid evidence="4">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573019.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71300">
        <property type="protein sequence ID" value="ADW71300"/>
        <property type="gene ID" value="AciX9_4348"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4348"/>
    <dbReference type="HOGENOM" id="CLU_077340_0_0_0"/>
    <dbReference type="OMA" id="TCECYAV"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW71300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="234" mass="25779" checksum="595DF9B84C87E4CC" modified="2011-04-05" version="1">MAAPRTNLLLEALSPESRKRLIDLSKAVDLPIRTPLQAQDEQPKHAYIMLSGIASVVVNLPEGGSAEVAVIGREGITSCISLLGPSAPPSECFMQVAGSGYKILFADLKAAFLDSEEIRTRILELAQQQTLTMSQIAACNKLHDNEARLSRWLLMVQDRLQEDLLPLTQEFLAEMLGSRRTTVAVSAGTLQRAGMIEYRRGKVTSLSRENLEAAACDCYKVSQRLFQALYKTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8X797</accession>
    <name>E8X797_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_4379</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
            <plasmid evidence="14">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573050.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71331">
        <property type="protein sequence ID" value="ADW71331"/>
        <property type="gene ID" value="AciX9_4379"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4379"/>
    <dbReference type="HOGENOM" id="CLU_743800_0_0_0"/>
    <dbReference type="OMA" id="HGSDSYF"/>
    <dbReference type="OrthoDB" id="1544679at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233770" evidence="11">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="12">
        <location>
            <begin position="323"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW71331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="438" mass="46343" checksum="0C93963EA71BF21B" modified="2011-04-05" version="1">MRSTTLTLVLAILGCSAALAQQSSGNPALIVPKLDVSLGYNFMRANAPPGGCPCFSLNGGYLAAGVHIVDWLSVEGEATGGRANDISLLGQNLNLITVAAGPRVTLSGHRIVPFGEALFGIAHGSDSYFPTGTSFTTSASSFALSAGGGLDYSINHRYAIRALDVQYLRTAFPNGNSNTQNHLMIGAGLVVKFGGHMHWSPAPVAREEKRPSEISFTCSSVTPTVKEGDIIEVSGHAFTSPDQLALDYAWTSDSGVIIGSGRMIAVKTAGMAPGDYHVKGKAALLSSPTTFAECEVPFHVSARPVAVANGAGSSLTPAEIAKSDVIFHENVQDALFDYDSAEIRPDAKVAIEHAGKFLTEHPDIQVLIEGYADDRGSAEYNLGLGAQRASAARTALMEQGIPPERLKIISYGKEAQVCVQQTEQCWQQNRRAAFSMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7B8</accession>
    <name>E8X7B8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71352">
        <property type="protein sequence ID" value="ADW71352"/>
        <property type="gene ID" value="AciX9_4401"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4401"/>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_0"/>
    <dbReference type="OMA" id="MGNEMQQ"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="124" mass="13781" checksum="BCB1AD893CEC085C" modified="2011-04-05" version="1">MRQAVPSLAADSQAQINSANPGELSRFKAEFFKALAHPLRIRIVDELRNGEVGVTHLCARLEVEQSSLSQQLAVLRARYIVNARKDGLSVLYSIRDPEIFSLLDVAKRIFNKHLVGVQGMLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7F7</accession>
    <name>E8X7F7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugal transfer protein TrbG/VirB9/CagX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573110.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71391">
        <property type="protein sequence ID" value="ADW71391"/>
        <property type="gene ID" value="AciX9_4445"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4445"/>
    <dbReference type="HOGENOM" id="CLU_087514_0_0_0"/>
    <dbReference type="OrthoDB" id="1175608at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010258">
        <property type="entry name" value="Conjugal_tfr_TrbG/VirB9/CagX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038161">
        <property type="entry name" value="VirB9/CagX/TrbG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03524">
        <property type="entry name" value="CagX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234481" evidence="1">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="280" mass="30694" checksum="6EC0B86A0CA9E01A" modified="2011-04-05" version="1">MKTPTTLLSGLILAGCTAIGFASTTPSPAHHLQPNPPRTIAVHDSEAPPVVRTGILQSTLIMLPAEEKVATVFGGNTADWVFDGGHVASRFISVKPKVANSTTNVHIVSDHGNEYTLQLTEITGDLDQHFDSKVFVTPGDQPGKDKLAAMPVFVPAAELEKAKQETEAARAAETAAVKAQTTKAEQYRSSYPGTLHFDYSWDPRKGRELGLQQIWHDDRFTYLRGQFQETPALYEMKDGKPSLINFDFADGLYTIPKDVAHGYLEIGKKKVDFNRTGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7G3</accession>
    <name>E8X7G3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VirB8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">AciX9_4451</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MP5ACTX9</strain>
            <plasmid evidence="8">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573116.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71397">
        <property type="protein sequence ID" value="ADW71397"/>
        <property type="gene ID" value="AciX9_4451"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4451"/>
    <dbReference type="HOGENOM" id="CLU_1037320_0_0_0"/>
    <dbReference type="OrthoDB" id="1214981at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007430">
        <property type="entry name" value="VirB8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04335">
        <property type="entry name" value="VirB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="VirB8" evidence="6">
        <location>
            <begin position="32"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADW71397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="268" mass="29931" checksum="8473D176C2F59D0B" modified="2011-04-05" version="1">MPTQLAPADTLTPADALLTDYVGNEIYAAHYSERRLSRFVIGTLSVILLFSFVLIHSLANRPVPNRYVRIDEMGRAQAIQYSDLSYSPREGEVRTYLTDWANYRYTVNRETVATKYPLNYYFLSAPIASRLMTEDNANHFASLVLSGQVEQSDDEVRNVTITSMTDETLSGVTIAKGTALIGVDRLYSPRNSREPRTEHWLLSVTYYLNPKQVSEQARIFPQFETINPLGLTITDFHENRVSVDPLVSASALPTFGAAAPRAAAGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7J6</accession>
    <name>E8X7J6_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX903</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid3 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX903</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002483">
        <property type="protein sequence ID" value="ADW71430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573149.1">
        <property type="nucleotide sequence ID" value="NC_015058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71430">
        <property type="protein sequence ID" value="ADW71430"/>
        <property type="gene ID" value="AciX9_4484"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4484"/>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_0"/>
    <dbReference type="OMA" id="DVPHVFQ"/>
    <dbReference type="OrthoDB" id="1587940at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX903"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="89"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="319" mass="34010" checksum="084393E875C3C616" modified="2011-04-05" version="1">MQTIRVDQGTASWLVQHPLGAEDEAAMTAMRAIVEPNKGKLRGVAARVPFDAIMERVSAPAGVVYEADSVGGISGWWCRPEDARPGEAVMHLHGGWFNWGSAQAFRHLAGHIARSAGVTAFVPDYRLAPEHPFPAAIEDARACYFGLIERGFTKLAVTGDSAGGNLALGLLIVAATSVQRALVGGVALSPVTDLTLSGESWSTRAVADPYFTQTQADELMRSYLDGNRPNDPLASPLYADLKGLPPLRVHVGNDEVLLDDSIRVVERAAAAGVDVRLDVWQGMVHGYLGGLGRLTASTATLQLIGDFLRERFANAAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7M5</accession>
    <name>E8X7M5_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4518</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4518"/>
    <dbReference type="EnsemblBacteria" id="ADW71459">
        <property type="protein sequence ID" value="ADW71459"/>
        <property type="gene ID" value="AciX9_4518"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4518"/>
    <dbReference type="HOGENOM" id="CLU_2342812_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="97" mass="10128" checksum="C80BD2E371E4C40A" modified="2011-04-05" version="1">MRLILALEKGPGASPIKAMCAVHGNAAGLRGESRQYTDMGDLVHSLAVAGVASHVSNYALKAIMAGYPSFFTLTKREAASLGVLFNTSEEEEGSNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7P4</accession>
    <name>E8X7P4_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4541</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX904</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid4 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX904</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002484">
        <property type="protein sequence ID" value="ADW71478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_4541"/>
    <dbReference type="EnsemblBacteria" id="ADW71478">
        <property type="protein sequence ID" value="ADW71478"/>
        <property type="gene ID" value="AciX9_4541"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4541"/>
    <dbReference type="HOGENOM" id="CLU_3043937_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX904"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="54" mass="6586" checksum="E369FF153AB4C724" modified="2011-04-05" version="1">MSKTLLYRHYTVCRDIELAARLDRQHNPQTRERLTRKLENLLIDEAILWPGWHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U7</accession>
    <name>E8X7U7_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4601</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573250.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71531">
        <property type="protein sequence ID" value="ADW71531"/>
        <property type="gene ID" value="AciX9_4601"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4601"/>
    <dbReference type="HOGENOM" id="CLU_2584812_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="80" mass="9277" checksum="9A856B6BF90EDC5A" modified="2011-04-05" version="1">MQARLDELLGGFHRRMDAQQSVEAKLADFGNRMDTRLQQEQAQALARQQQEQALKQQQEQAKTKEPEIEREHSRGFGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7V8</accession>
    <name>E8X7V8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_4612</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
            <plasmid evidence="3">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71542">
        <property type="protein sequence ID" value="ADW71542"/>
        <property type="gene ID" value="AciX9_4612"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4612"/>
    <dbReference type="HOGENOM" id="CLU_459881_0_0_0"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW71542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="593" mass="64936" checksum="D3C57064BB071600" modified="2011-04-05" version="1">MPVTGVVLNAITGKPIEGAVVGTLRPEDRRYLTTPPRNLISPRPSPPHKIPGPKQQQMTDAEGRFRFESMDFKERQYFYVTKAAYLAPDSSGSSIPIFEVSVMPGMGELRFKLNPEAELNGKVISSDGLVMKSLMVSLYRVQYTAGRPHWIHIGQQRTDTSGSYHFGELPAGTYFVVSQWLFDNDPLPPDTNTCNDSPYMPDGGFAPESEPGVLDFHKAVPIILTEGGHAVADLRLQHQVFHPVTILHDPDLSPGFLEIVDRNGRNLELPVSPSVNCVRRLHPSGDRQQSTIHLPDGNYTFHQHAAYSLKDPFKTGGAKQPVFLGGYISVAVAGKPVSVMLPAVPEDDAAPVEIRVHHEKTTSSADGSTHDVCSPKRPGGVLFVSPGTKLPPPFQIEMLSADNFGGQGVTVHVTEKNTDLYEAVGSQPGRFWLITQVLDLGYVSKISAAGLDLLQHPLVIGMDRTSVALDITVRDDCGRIHFEKPWTKPAPGAVLADAVGIVNPFFELLVPQFFGATPHGQFSQERSMMELGRPASITVGNLPPGHYKLFEAFDESAVSNFSPVELDKRLGPAKHIWLKPREQVNLNILDLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8WVD1</accession>
    <name>E8WVD1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013579702.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1317"/>
    <dbReference type="EnsemblBacteria" id="ADW68379">
        <property type="protein sequence ID" value="ADW68379"/>
        <property type="gene ID" value="AciX9_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1317"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045463_2_0_0"/>
    <dbReference type="OMA" id="MDQPVKG"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003233404" evidence="1">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="299" mass="31674" checksum="F6D166FB25934893" modified="2011-04-05" version="1">MPSFSARSLAITFAVLTSIASAQAPASETLIADAKSQPESLTLAPNGVLIVGSASSPFIYKLRPGSATAEKFVDATAEGPGTFFFGMLAESATNTLWSCQLTPIPDTKPTRRRTTLRAFDLTTAAPRLRWTLPGETSTCNDLALAPAPDKALYFTDTANSKIYRLASGATTPELYLEDRLLNGVDGITFLDGVLYVNNVVFNKLYRIPVDAAGKPGRPIDIWMDQPVKGPDGMRSAAGKLLVAENGSGRISLLTITGERASVTVLKEGLTTPTAVEPAGNTIWIAERGTGKAISIPMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8WX74</accession>
    <name>E8WX74_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_2692</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581031.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2692"/>
    <dbReference type="EnsemblBacteria" id="ADW69716">
        <property type="protein sequence ID" value="ADW69716"/>
        <property type="gene ID" value="AciX9_2692"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2692"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531854_0_0_0"/>
    <dbReference type="OMA" id="GHNDNGP"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003230402" evidence="1">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="283"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW69716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="512" mass="54854" checksum="73C9664B04E41040" modified="2011-04-05" version="1">MQTILVAALLATFTALSPAARAQGDPPKTFNSATAATRGPGTKVRIDLIGDSTQTDNAGYGRGFCANFTPEVDCVNMAKGGASTKTFREQGLWDRSLATKPDYMVIQFGHNDMEKVDGVATADRQVSMADYEANLRRFVTEARAAGIKPVLCTPLTRRYFEADGKIHSDLLGHAATMKRVAKDMQVPLIDLQGESIALLDKTGETQGNKLAITKKDDEGKTIFDKTHLNWAGSYIFGRIVAKDLGEEVPALHKYVLPTAAKLPPEGLKAMKIIEGGPVKIVLVGDSTVATGGGWGPGFCAVMTPNVTCVDVALNGRSTKSFVDEGAWKKALDEHGDYYLIQFGHNDQKPDVARHTDANGSFQDYLRLYIRGVRSVGGVPVLVTSLSRRTMKDGKIVEDLKDYAAATKKVGAEEGITVVDLNSISTALLNHMTQAQADEFNAVGHADQRAESGKSTIDRTHLNPHGQAVFGRIVADNLVRTQVELGPDVVGEAAGKSIVPTFAVTQAAPTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYE5</accession>
    <name>E8WYE5_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">AciX9_2828</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW69851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581166.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2828"/>
    <dbReference type="EnsemblBacteria" id="ADW69851">
        <property type="protein sequence ID" value="ADW69851"/>
        <property type="gene ID" value="AciX9_2828"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2828"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_2_0"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADW69851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="324" mass="35593" checksum="235A129B07A49C7A" modified="2011-04-05" version="1">MKIYRSLSELPADLGPVVATIGNFDGVHRGHRWVIDQVNARARTLCLPSLLITFDPHPVRVLRPDAPHSLITPLEQKLALLGETGIDAALILPFTPELSRLTARQFAEILANDIHVREVHEGENFRFGHKAEAGMEGLEQLGHELGFTAQTYSPHILRAAPVSSSRIRNLIAAGALHHARALTGRPFAIQSTPASGRGYGTRYTVPTINLAPYPELLPAKGVYVTTLKVGTGPHAETFNAVTNIGDRPTFGADSFAVESHLLNFHAVDLNEQTPLELTFLQRLRPEIRWPNPEALRTQIGLDVKKAQRYFALCTTLTKEKAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8WYV0</accession>
    <name>E8WYV0_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase HD sub domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580105.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1738"/>
    <dbReference type="EnsemblBacteria" id="ADW68786">
        <property type="protein sequence ID" value="ADW68786"/>
        <property type="gene ID" value="AciX9_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1738"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070871_0_0_0"/>
    <dbReference type="OMA" id="HPRPDFK"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="221" mass="24541" checksum="CA6112987F33A01B" modified="2011-04-05" version="1">MSTTLQQPAVSPLDTVTLPQSKLIQQITEFVRDTESDLLFNHSSRVYYFGALAGRRRGLTFDPELLYAGAMFHDIGLIPAYSSATERFEVDGANAARSFLQEHGIDAAQIDHVWNAIALHTTPGIPQHMHPVVALVTAGVEMDVLGIDYNLFADPAREAVVSRFPRTPHFKEHILQAFYDGIHHKPDTTFGNVKADVLADKNPAFQRGNFCSVIRNSPWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN3</accession>
    <name>E8WZN3_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="10" type="ordered locus">AciX9_2984</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581321.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2984"/>
    <dbReference type="EnsemblBacteria" id="ADW70007">
        <property type="protein sequence ID" value="ADW70007"/>
        <property type="gene ID" value="AciX9_2984"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2984"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_0"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="169" mass="19963" checksum="A487C8AE6BCA4E0E" modified="2011-04-05" version="1">MKCPYCAFTQDRVVDSRESKEADSIRRRRECERCNKRFTTYERIDEIPYMVVKKDGRRERFDRQKVLGGLLQACQKRSISSAQLERIVDEVETFIVDSPERERLTTEVGELIMDRLKNIDTVAYIRFASVYRDFKDVREFKAELEELLGGAKKHPEDPRKLLKPTPRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8WZN9</accession>
    <name>E8WZN9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M29 aminopeptidase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">AciX9_2990</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_2990"/>
    <dbReference type="MEROPS" id="M29.001"/>
    <dbReference type="EnsemblBacteria" id="ADW70013">
        <property type="protein sequence ID" value="ADW70013"/>
        <property type="gene ID" value="AciX9_2990"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_2990"/>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054346_1_0_0"/>
    <dbReference type="OMA" id="CNANIPT"/>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADW70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="417" mass="45070" checksum="DCA5B3BD9CF28ABD" modified="2011-04-05" version="1">MTFDFAALSFAEKLDRFARLAVHVGLNLQPGQELLITASTEMIPFVRLITEHAYKAGALLVTTTYGDDQAILSRYKYANDASFDYAPVWMAEGIATAFRSGAARLALSGADPTLLSAQDPAKVSRANIAGSKANKPAMEMITRHAINWSICAAATSAWSRLVFPGIPEEEAMLKLWDAIFYASRATSEDPVAAWKAHSANIHQRVAYLNEKRYHSLRFHSADGKTDLTVGLADDHLWAGGGGESGNGVFCNANIPTEECFTTPHKDRIDGVVHASKPLSHQGTLIENIMCRFEKGRIVEATASAGEDALNRLISTDEGARSLGEVALVPHSSPIAQSGILFYNTLFDENAASHIALGQAYATCLIEGEHMDETTLAAKGANHSLIHVDWMIGSAQMDVDGIAHDGTSEPLMRQGEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8X083</accession>
    <name>E8X083_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ordered locus">AciX9_3044</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581378.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3044"/>
    <dbReference type="EnsemblBacteria" id="ADW70064">
        <property type="protein sequence ID" value="ADW70064"/>
        <property type="gene ID" value="AciX9_3044"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3044"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_0"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADW70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="179" mass="19751" checksum="4CC87E56FDB184DC" modified="2011-04-05" version="1">MSTIVNCEPLKELIRTVPDFPKPGILFYDITTLLKNKAGMAQLIDAFAAYYIDKEIDLVLGIEARGFIFGPALAYRLNAGFVPVRKPKKLPAPTAKVTYDLEYGSDALEIHLDAIEPGQRVVIVDDLLATGGTMQATVKLVRQLGGEIAGIGFAIELDFLKGRAKFQEYDVFSLLHYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0C9</accession>
    <name>E8X0C9_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3090</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3090"/>
    <dbReference type="EnsemblBacteria" id="ADW70110">
        <property type="protein sequence ID" value="ADW70110"/>
        <property type="gene ID" value="AciX9_3090"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3090"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053823_0_0_0"/>
    <dbReference type="OMA" id="HITFNDG"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012669">
        <property type="entry name" value="Pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09492">
        <property type="entry name" value="Pec_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02474">
        <property type="entry name" value="pec_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234225" evidence="2">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="452" mass="49541" checksum="DF1555BB51B7DF45" modified="2011-04-05" version="1">MSKALLRAGLSIALACGSVAGFASVIGTNKPALDITRARILQLPAGQQKVWLDYLKRSEEQRAADRAALAGERKPGMAVPDLPKESSSAHSMPLDREAAWYGTAEARHIADVIVSFQTPAGGWSKNMDMAGTLRQPGQSYAPDNLSRHPSEADFDTPKDPNWNYVGTLDNDATNTELRFLARVAGQTRTEGESYRKSFLRGLRYLLAAQFPNGGWPQVWPLEGGYHDAITYNDNAVTETADLLTQATSGMGDYAFVPAELRHRSAEAMQRALQCIVTTQIVVHGKRTGWPQQQDPLTLAPESGRNYEPPALATGESADILIYLMGLPHPSPAIRAAVRNGVDWLKSVEVYGQEWTGSRRDAEGRHLVAHAGSGPIWARYYSIETGKPIFGDRDKSLHDDVNELSLERRNGYSWYSDGPLKALTAYAILGRSRPGKYLPTPHGYGVKSSKHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8X0M1</accession>
    <name>E8X0M1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_1926</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013580291.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1926"/>
    <dbReference type="EnsemblBacteria" id="ADW68972">
        <property type="protein sequence ID" value="ADW68972"/>
        <property type="gene ID" value="AciX9_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1926"/>
    <dbReference type="eggNOG" id="COG2886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154570_0_0_0"/>
    <dbReference type="OrthoDB" id="2031541at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="88" mass="9705" checksum="99C7CC511D5A005F" modified="2011-04-05" version="1">MTITVELPDDLASYADSGRKALEALAIEGYRTGKLTQRQAAAMLGLYWLDFEGLLKERGIMEGAYDVEAFLSDIRTMDELRAAGMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8X2U3</accession>
    <name>E8X2U3_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">AciX9_3382</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013581702.1">
        <property type="nucleotide sequence ID" value="NC_015064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3382"/>
    <dbReference type="EnsemblBacteria" id="ADW70390">
        <property type="protein sequence ID" value="ADW70390"/>
        <property type="gene ID" value="AciX9_3382"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3382"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022604_0_0_0"/>
    <dbReference type="OMA" id="DYQQGFS"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="725" mass="77338" checksum="4BDB40E7DAB4A51D" modified="2011-04-05" version="1">MTHPSRQTNSFNTPNTLVCPTLIAASSRLGWASSEARPLLPKLAIAAAFAFTLSFSHAQQPQAQNPPALPTTPTPPSVPPISAFTPGVPTLLTGLPDTIPTRSAPAGLVSRRFFGPYRRPTVPPLFPGAGDRLRSLVHDGKLYLSAKDAIALAIESNLDVEVERYNLLLADTDKLRASGGGTLRGIDYTIAEPPNGVGGPGSPLLNTAAVNPNPTTPTVTDLTSLNSNTQATTNLSEASTATAVYAAGPSIPLFDPNLFLEAGYFRRSDTVTLTGGTTGTTGTTGTGATTGATTTTPGALNFVTANVSYIQGFHTGTQLELTVNNDSSVIYGSNSSYDPFSRPSTSGTVTQPLLRGFGRDVNTRFIKIANENKKIGRLLFEQQVLETVYGISRIYFDLVSLGENVAVQQEALRAAQKLRDDDANQVIEGTLAPIELTRVSALVSSSEFSLIQAQGLYRQQEVILRNQLLRADSPVFAAGFTEIVPTDTIVVPELLPETPVGDLIDRALERRPDLAQAQLQIKTGQINVAASRNQALPQLNAYVNAQTRGSTEQAYEQLGTPGTGIPTLPQNFALGGLRVSTIVQGGVQLNLPLRNRVAESDAARDGIQLRQVQARAEKLSNQIRQDIENATIAVDTAFAAYKASRASRGAQEQLLSAERDKLEFGQSTPLNVLQDEAYVAQAKSTEIAARSNYQKAQIELDRTLGDLLEKNGITLEDAVQGTVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8X3K6</accession>
    <name>E8X3K6_GRATM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ordered locus">AciX9_1134</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MP5ACTX9</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW68197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_1134"/>
    <dbReference type="EnsemblBacteria" id="ADW68197">
        <property type="protein sequence ID" value="ADW68197"/>
        <property type="gene ID" value="AciX9_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_1134"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_1_0"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADW68197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="188" mass="20985" checksum="7C9283C317F6CACF" modified="2011-04-05" version="1">MAKTEASAAKKGAGKKSGVKLHAVLKWPDPVLAKKGVEVTAFDDRLKTLVDEMFESMYEAQGIGLAAPQIGISERITVIDVSFKKNPKDRLALINPVIIEAEGKQVEEEGCLSLPDIREKVSRAGWVKVKAQDVTGTWFEVEGDELLARALQHEIDHLDGVLFIDRISRLKRELVLRKIKKMQKNGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8X4W8</accession>
    <name>E8X4W8_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNARE associated Golgi protein-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">AciX9_3604</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MP5ACTX9</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002480">
        <property type="protein sequence ID" value="ADW70607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1198114.AciX9_3604"/>
    <dbReference type="EnsemblBacteria" id="ADW70607">
        <property type="protein sequence ID" value="ADW70607"/>
        <property type="gene ID" value="AciX9_3604"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3604"/>
    <dbReference type="eggNOG" id="COG1238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099466_0_0_0"/>
    <dbReference type="OMA" id="INRERYE"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADW70607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="237" mass="26067" checksum="F0698BDD1CEEED6A" modified="2011-04-05" version="1">MNGLGLVLAGIPWRKIGGWLVKSKVWLLAVLQPFGVFGILILAIVDSSSMPLPFLDPLVVSYGAADHKKALLYCLMASLGSAIGSMVPYYLGRAGGELFLLKRINRERYEKLRDRFEKQEFLAIMLPAMCPPPMPVKLFELAAGVFEMRPVSYFLAIASGKFVRFLIESILVIVYGPAILSTSLRMLHRHLGVVLAVMGIIAVGIVIYVLRKVFDRRRGIALPVEDEAIEVGPGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8X6T2</accession>
    <name>E8X6T2_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">AciX9_3956</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pACIX902</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid2 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MP5ACTX9</strain>
            <plasmid evidence="6">Plasmid pACIX902</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002482">
        <property type="protein sequence ID" value="ADW71232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71232">
        <property type="protein sequence ID" value="ADW71232"/>
        <property type="gene ID" value="AciX9_3956"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_3956"/>
    <dbReference type="HOGENOM" id="CLU_038343_3_1_0"/>
    <dbReference type="OMA" id="DIAFRWT"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX902"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003234460" evidence="3">
        <location>
            <begin position="31"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADW71232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="246" mass="26786" checksum="3D0EE6BE2164C1CD" modified="2011-04-05" version="1">MMRTMRVRLINYGFLLLALLVMATAVSAEAEKPRMAAGGPAGVQALSQQPAQGADSAPNYRVNPGDVLDIAFRWTPEFNQTVTVQPDGHVILTSAGDIKMGGLTLLQVRDLIINASSSKVVNPEVAVTLKDFERPRIAIGGEVVTPGKYDLRQPTTALQAIMLAGGPKDSAQLSQILLFRPMPDGMSEVHRINFHHLDHGKHPPEDIQLKPGDMLLIPRDKLTKIGRYVRTFNLGVYFNPATGAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8X7U1</accession>
    <name>E8X7U1_GRATM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">AciX9_4595</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)</name>
        <dbReference type="NCBI Taxonomy" id="1198114"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Acidobacteria</taxon>
            <taxon>Acidobacteriales</taxon>
            <taxon>Acidobacteriaceae</taxon>
            <taxon>Granulicella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pACIX905</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid5 of Acidobacterium sp. MP5ACTX9.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Teshima H."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Tapia R."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Ovchinnikova G."/>
                <person name="Pagani I."/>
                <person name="Rawat S.R."/>
                <person name="Mannisto M."/>
                <person name="Haggblom M.M."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MP5ACTX9</strain>
            <plasmid evidence="2">Plasmid pACIX905</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002485">
        <property type="protein sequence ID" value="ADW71525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013573244.1">
        <property type="nucleotide sequence ID" value="NC_015060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADW71525">
        <property type="protein sequence ID" value="ADW71525"/>
        <property type="gene ID" value="AciX9_4595"/>
    </dbReference>
    <dbReference type="KEGG" id="acm:AciX9_4595"/>
    <dbReference type="HOGENOM" id="CLU_1400758_0_0_0"/>
    <dbReference type="OMA" id="FIMRERT"/>
    <dbReference type="OrthoDB" id="2194802at2"/>
    <dbReference type="Proteomes" id="UP000000343">
        <property type="component" value="Plasmid pACIX905"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADW71525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000343"/>
        </source>
    </evidence>
    <sequence length="194" mass="21512" checksum="B11F995694610AF0" modified="2011-04-05" version="1">MSFIMRERTLKIRSALKIARTVFAIGLAACCVGQTAVPATPGKLELRLLPQSVWMKIPQTFTILMVNGTDHDVRVPTPSLECGDVPHGTVRLRLNFKPYTPGVAGVGGGCVNDFSYSPMPDVIKGWKVLRPGESLTLATINDRVLAQEAGSYDYWAHYDPPGMPEADREWLRKAGTDYPKEELDSAHVKFVKRR</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>